# bib

id: cord-267333-8b7hvorz
author: Watson, John T.
title: Unraveling the Mysteries of Middle East Respiratory Syndrome Coronavirus
date: 2014-06-17
extension: .txt
mime: text/plain
words: 1355
sentence: 41
flesch: 35
cache: cache/cord-267333-8b7hvorz.txt
txt: txt/cord-267333-8b7hvorz.txt
summary:
  respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV) Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus Close relative of human Middle East respiratory syndrome coronavirus in bat Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Antibodies against MERS coronavirus in dromedary camels MERS coronaviruses in dromedary camels, Egypt. Latest outbreak news from ProMED-mail: novel coronavirus-Middle East Middle East respiratory syndrome coronavirus (MERS-CoV)-update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update-as of 20 State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Family cluster of Middle East respiratory syndrome coronavirus infections Hospital outbreak of Middle East


id: cord-282293-pdhjl508
author: Park, Wan Beom
date: 2016-01-14
extension: .txt
mime: text/plain
words: 1579
sentence: 61
flesch: 49
cache: cache/cord-282293-pdhjl508.txt
txt: txt/cord-282293-pdhjl508.txt
title:
  Isolation of Middle East Respiratory Syndrome Coronavirus from a Patient of the 2015 Korean Outbreak

summary:
  key: cord-282293-pdhjl508 authors: Park, Wan Beom; Kwon, Nak-Jung; Choe, Pyoeng Gyun; Choi, Su-Jin; Oh, Hong Sang; Lee, Sang Min; Chong, Hyonyong; Kim, Jong-Il; Song, Kyoung-Ho; Bang, Ji Hwan; Kim, Eu Suk; Kim, Hong-Bin; Park, Sang Won; Kim, Nam Joong; Oh, Myoung-don title: Isolation of Middle East Respiratory Syndrome Coronavirus from a Patient of the 2015 Korean Outbreak date: 2016-01-14 journal: J Korean Med Sci DOI: 10.3346/jkms.2016.31.2.315 sha: doc_id: 282293 cord_uid: pdhjl508 During the 2015 outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Korea, 186 persons were infected, resulting in 38 fatalities. Middle East respiratory syndrome corona Saudi Arabia: disease outbreak news Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study What needs to be done to control the spread of Middle East respiratory syndrome coronavirus? Middle East respiratory syndrome coronavirus superspreading Event Involving 81 Persons, Korea Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus Microevolution of outbreak-associated Middle East respiratory syndrome coronavirus Variations in spike glycoprotein gene of MERS-CoV Origin and possible genetic recombination of the Middle East respiratory syndrome coronavirus from the first imported case in China: phylogenetics and coalescence analysis Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees MEGA6: molecular evolutionary genetics analysis version 6.0


id: cord-007828-c7jxj74b
author: Memish, Ziad A.
title: Middle East respiratory syndrome coronavirus infection control: The missing piece?
date: 2014-11-25
extension: .txt
mime: text/plain
words: 1935
sentence: 80
flesch: 42
cache: cache/cord-007828-c7jxj74b.txt
txt: txt/cord-007828-c7jxj74b.txt
summary:
  key: cord-007828-c7jxj74b authors: Memish, Ziad A.; Al-Tawfiq, Jaffar A. title: Middle East respiratory syndrome coronavirus infection control: The missing piece? date: 2014-11-25 journal: Am J Infect Control DOI: 10.1016/j.ajic.2014.08.003 sha: doc_id: 7828 cord_uid: c7jxj74b nan Since the initial occurrence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, 1,2 the disease had caused 837 cases, with a case fatality rate of 34.7%. Epidemiological update Middle East respiratory syndrome coronavirus (MERS-CoV) Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature updateeas of 9 Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Assessment of potential risk factors of infection of Middle East respiratory syndrome coronavirus (MERS-CoV) among health care personnel in a health care setting Global alert and response (GAR): infection prevention and control of epidemic-and pandemic-prone acute respiratory infections in health care Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Infection prevention and control measures for acute respiratory infections in healthcare settings: an update Identification of a novel coronavirus in patients with severe acute respiratory syndrome Severe acute respiratory syndrome The severe acute respiratory syndrome World Health Organization.


id: cord-265279-0zjpqnqp
author: Hoteit, Rouba
title: Use of the Human Coronavirus 2012 (MERS) GeneSig kit for MERS-CoV detection
date: 2016-04-16
extension: .txt
mime: text/plain
words: 1961
sentence: 66
flesch: 45
cache: cache/cord-265279-0zjpqnqp.txt
txt: txt/cord-265279-0zjpqnqp.txt
summary:
  To our knowledge, this is the first report that describes the clinical application of the GeneSig kit in the MERS-CoV epidemic era. Hospital-associated outbreak of Middle East Respiratory Syndrome Coronavirus: a serologic, epidemiologic, and clinical description Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Update: Severe respiratory illness associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-worldwide Transmission of MERS-coronavirus in household contacts Molecular pathology of emerging coronavirus infections Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities Middle East respiratory syndrome coronavirus (MERS-CoV) c WHO Infection control and MERS-CoV in health-care workers key: cord-265279-0zjpqnqp authors: Hoteit, Rouba; Shammaa, Dina; Mahfouz, Rami title: Use of the Human Coronavirus 2012 (MERS)


id: cord-287886-41isp0wj
author: Al-Tawfiq, Jaffar A
date: 2016-11-08
extension: .txt
mime: text/plain
words: 2273
sentence: 112
flesch: 52
cache: cache/cord-287886-41isp0wj.txt
txt: txt/cord-287886-41isp0wj.txt
title:
  Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia

summary:
  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Hospital outbreak of Middle East respiratory syndrome coronavirus Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Taking stock of the first 133 MERS coronavirus cases globally--Is the epidemic changing? State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Family cluster of Middle East respiratory syndrome coronavirus infections A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study MERS-CoV outbreak in Jeddah--a link to health care facilities An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia An update on Middle East respiratory syndrome: 2 years later Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution epidemiological findings from a retrospective investigation The Characteristics of Middle Eastern Respiratory Syndrome Coronavirus Transmission Dynamics in South Korea Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus Managing MERS-CoV in the healthcare setting Middle East respiratory syndrome coronavirus disease in children MERS-CoV summary and literature Middle East respiratory syndrome coronavirus (MERS-CoV) Case List of MoH/WHO Novel Coronavirus MERS nCoV Announced Cases Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia Al Abdallat MM. Despite the total number of MERS cases increasing, especially in KSA, the number of pediatric cases remained low during the study period.


id: cord-264901-w285on4x
author: Ahmadzadeh, Jamal
title: The risk factors associated with MERS-CoV patient fatality: A global survey
date: 2019-07-31
extension: .txt
mime: text/plain
words: 2517
sentence: 97
flesch: 49
cache: cache/cord-264901-w285on4x.txt
txt: txt/cord-264901-w285on4x.txt
summary:
  No molecular evidence of MERS-CoV circulation in Jeddah, Saudi Arabia between 2010-2012: a single-center retrospective study The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health Risk factors for Middle East respiratory syndrome coronavirus infection among healthcare personnel Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus Respiratory tract infection during hajj Hospital outbreak of Middle East respiratory syndrome coronavirus Role of severe acute respiratory syndrome coronavirus Viroporins E, 3a, and 8a in replication and pathogenesis MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Lack of nasal carriage of novel corona virus (HCoV-EMC) in French hajj pilgrims returning from the hajj 2012, despite a high rate of respiratory symptoms Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Hospital-associated Middle East respiratory syndrome coronavirus infections Bat origin of human coronaviruses Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Knowledge and practices regarding Middle East respiratory syndrome coronavirus among camel handlers in a slaughterhouse An update to middle east respiratory syndrome coronavirus and risk of a pandemic in 2019 Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Family cluster of Middle East respiratory syndrome coronavirus infections Etiology of severe community-acquired pneumonia during the 2013 hajj-part of the MERS-CoV surveillance program Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1. 2017 to 17.1. The characteristics and the number of MERS cases per year can be found in .


id: cord-272306-92rz2byz
author: Morra, Mostafa Ebraheem
date: 2018-04-17
extension: .txt
mime: text/plain
words: 2496
sentence: 99
flesch: 38
cache: cache/cord-272306-92rz2byz.txt
txt: txt/cord-272306-92rz2byz.txt
title:
  Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta‐analysis

summary:
  Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Family cluster of Middle East respiratory syndrome coronavirus infections Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Treatment with interferon-[alpha] 2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration Case report guidelines The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses Meta-analysis in clinical trials Measuring inconsistency in meta-analyses Meta-analysis of genetic association studies Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches Post-dengue acute disseminated encephalomyelitis: a case report and meta-analysis MERS CoV infection in two renal transplant recipients: case report Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection A patient with severe respiratory failure caused by novel human coronavirus Ribavirin and interferon-alpha2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Middle East respiratory syndrome coronavirus in children Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Infection prevention/control and management guidelines for patients with Middle East respiratory syndrome coronavirus (MERS CoV) infection Severe acute respiratory syndrome vs. the Middle East respiratory syndrome Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis MERS surges again, but pandemic jitters ease Middle East respiratory syndrome coronavirus (MERS-CoV)


id: cord-030010-wy3kj68l
author: Abidin, Crystal
title: Feeling Asian Together: Coping With #COVIDRacism on Subtle Asian Traits
date: 2020-07-30
extension: .txt
mime: text/plain
words: 2295
sentence: 73
flesch: 41
cache: cache/cord-030010-wy3kj68l.txt
txt: txt/cord-030010-wy3kj68l.txt
summary:
  (For the record, the authors' favorite meme was when SAT members collectively agreed that all our Asian mothers were graduating from the WhatsApp and WeChat University of Misinformation; someone even designed a mock graduation certificate for our moms.) In response to such shared struggles, as participant-researchers we observed that SAT members collectively cope with the rising prejudice against Asians through Catharsis, Escalation, and Problem solving.


id: cord-022046-q1exf47s
author: Toosy, Arshad Haroon
title: An Overview of Middle East Respiratory Syndrome in the Middle East
date: 2018-09-28
extension: .txt
mime: text/plain
words: 2929
sentence: 114
flesch: 43
cache: cache/cord-022046-q1exf47s.txt
txt: txt/cord-022046-q1exf47s.txt
summary:
  Available at An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronaviruses in dromedary camels Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Antibodies against MERS coronavirus in dromedaries Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Isolation of MERS Coronavirus from a Dromedary Camel MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia 5, 10 The temporal dynamics of MERS infection in DCs in Al-Ahsa, KSA, was examined by collecting nasal swabs and lung tissue during postmortem examination from two independent groups of animals over the course of a year and testing these for MERS-CoV RNA by real-time reverse-transcriptase polymerase chain reaction (RT-rtPCR).


id: cord-138656-8iyynbup
author: Furuyama, Taima N.
date: 2020-06-20
extension: .txt
mime: text/plain
words: 3036
sentence: 107
flesch: 50
cache: cache/cord-138656-8iyynbup.txt
txt: txt/cord-138656-8iyynbup.txt
title:
  Temporal data series of COVID-19 epidemics in the USA, Asia and Europe suggests a selective sweep of SARS-CoV-2 Spike D614G variant

summary:
  If there is a correlation between the D614G variant prevalence and higher SARS-CoV-2 transmission, then the epidemiological data might reveal a significant correlation between D614G prevalence and the growth rate coefficients of epidemic curves globally. This is observed from D614G distribution data.


id: cord-002070-8y24j34j
author: Adney, Danielle R.
title: Infection, Replication, and Transmission of Middle East Respiratory Syndrome Coronavirus in Alpacas
date: 2016-06-17
extension: .txt
mime: text/plain
words: 3112
sentence: 117
flesch: 38
cache: cache/cord-002070-8y24j34j.txt
txt: txt/cord-002070-8y24j34j.txt
summary:
  Nasal swab specimens were collected from infected animals immediately before challenge, on days 1-5 postinfection, and on day 10 postinfection. The 3 co-housed animals (A4-A6) were placed in the room with the infected animals 2 days after initial virus infection.


id: cord-269232-rhhmvnlp
author: Joseph, Sunitha
title: First isolation of West Nile virus from a dromedary camel
date: 2016-06-08
extension: .txt
mime: text/plain
words: 3167
sentence: 121
flesch: 50
cache: cache/cord-269232-rhhmvnlp.txt
txt: txt/cord-269232-rhhmvnlp.txt
summary:
  15 Tissue culture cell extracts infected with dromedary WNV were centrifuged at 19 000g at 4°C. West Nile virus in a dromedary S Joseph et al Viral diseases of new world camelids A transversal study on antibodies against selected pathogens in dromedary camels in the Canary Islands Rift Valley and West Nile virus antibodies in camels Emerging viral diseases in dromedary camels in the Southern Morocco Seroepidemiological studies for the detection of antibodies against nine infectious diseases in dairy dromedaries (Part-1) Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age A sensitive and specific antigen detection assay for Middle East


id: cord-259051-6kuh4njb
author: Elkholy, Amgad A.
date: 2019-05-02
extension: .txt
mime: text/plain
words: 3283
sentence: 130
flesch: 38
cache: cache/cord-259051-6kuh4njb.txt
txt: txt/cord-259051-6kuh4njb.txt
title:
  MERS-CoV infection among healthcare workers and risk factors for death: Retrospective analysis of all laboratory-confirmed cases reported to WHO from 2012 to 2 June 2018

summary:
  Compared with non-healthcare workers cases, healthcare workers cases were younger (P < 0.001), more likely to be female (P < 0.001), non-nationals (P < 0.001) and asymptomatic (P < 0.001), and have fewer comorbidities (P < 0.001) and higher rates of survival (P < 0.001). Specific IPC measures which may have contributed to the decreased case fatality rate include more systematic use of appropriate personal protective equipment and increased testing of asymptomatic personnel which effectively increases the detection of asymptomatic healthcare workers who are less likely to die, therefore increasing the denominator of healthcare worker cases and decreasing the case fatality rate.


id: cord-256784-wfaqim7d
author: Modjarrad, Kayvon
title: MERS-CoV vaccine candidates in development: The current landscape
date: 2016-06-03
extension: .txt
mime: text/plain
words: 3339
sentence: 122
flesch: 34
cache: cache/cord-256784-wfaqim7d.txt
txt: txt/cord-256784-wfaqim7d.txt
summary:
  Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Preand postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Family cluster of Middle East respiratory syndrome coronavirus infections Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Hospital outbreak of Middle East respiratory syndrome coronavirus Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health Hendra virus An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Animal models of Middle East respiratory syndrome coronavirus infection Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia epidemiological findings from a retrospective investigation East Respiratory Syndrome Coronavirus (MERS-CoV) Summary and Literature Update-as of 11 Update: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea A decade after SARS: strategies for controlling emerging coronaviruses Detection of coronaviruses in bats of various species in Italy Diversity of coronavirus in bats from Eastern Thailand MERS-related betacoronavirus in Vespertilio superans bats Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai Antibodies against MERS coronavirus in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus MERS: emergence of a novel human coronavirus Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Update: severe respiratory illness associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-worldwide Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Middle East respiratory syndrome novel corona MERS-CoV infection.


id: cord-263042-qdmunb9l
author: Zhao, Yongkun
date: 2016-11-24
extension: .txt
mime: text/plain
words: 3379
sentence: 120
flesch: 44
cache: cache/cord-263042-qdmunb9l.txt
txt: txt/cord-263042-qdmunb9l.txt
title:
  Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model

summary:
  Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Transmission of MERS-coronavirus in household contacts Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays Towards improving clinical management of Middle East respiratory syndrome coronavirus infection Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab')2 in mice Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies Severe acute respiratory syndrome Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaques Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Rapid generation of a mouse model for Middle East respiratory syndrome Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Treatment with hyperimmune equine immunoglobulin or immunoglobulin fragments completely protects rodents from Ebola virus infection Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice Middle East respiratory syndrome Ad5-hDPP4 transduced BALB/c mice (6wks, female) were injected intraperitoneally with 200 mL horse serum However, neutralizing antibody titers in MERS patients are generally low and the limited number of MERS survivors makes this approach impractical (Drosten et al., 2013) .


id: cord-283586-o8m6xdra
author: Spanakis, Nikolaos
date: 2014-12-31
extension: .txt
mime: text/plain
words: 3280
sentence: 129
flesch: 37
cache: cache/cord-283586-o8m6xdra.txt
txt: txt/cord-283586-o8m6xdra.txt
title:
  Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

summary:
  Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Clinical Decision Making Tool for Treatment of MERS-CoV v A case of imported Middle East respiratory syndrome coronavirus infection and public health response Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Ribavirin and interferon (IFN)-␣-2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus (MERS-CoV): a preliminary report of two cases Treatment with interferon-␣2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Schering Corp Product information. Switzerland: WHO Long-term SARS coronavirus excretion from patient cohort Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential Interferon-␤ and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Inhibition of novel ␤ coronavirus replication by a combination of interferon-␣2b and ribavirin In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) coronavirus infection Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Hospital outbreak of Middle East


id: cord-286631-3fmg3scx
author: Pormohammad, Ali
date: 2020-06-05
extension: .txt
mime: text/plain
words: 3676
sentence: 102
flesch: 28
cache: cache/cord-286631-3fmg3scx.txt
txt: txt/cord-286631-3fmg3scx.txt
title:
  Comparison of confirmed COVID‐19 with SARS and MERS cases ‐ Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta‐analysis

summary:
  Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Association between severity of MERS-CoV infection and incubation period Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Identified transmission dynamics of Middle East respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia Preliminary epidemiologic assessment of MERS-CoV outbreak in South Korea Clinical and epidemiologic characteristics of spreaders of Middle East respiratory syndrome coronavirus during the 2015 outbreak in Korea Transmission of MERScoronavirus in household contacts Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Hospital outbreaks of middle east respiratory syndrome Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Outbreaks of Middle East respiratory syndrome in two hospitals initiated by a single patient in Daejeon Covid-19: WHO declares pandemic because of alarming levels of spread, severity, and inaction Comparison of severe and non-severe COVID-19 pneumonia: review and meta-analysis. A novel coronavirus outbreak of global health concern Three Emerging Coronaviruses in Two Decades: the Story of SARS, MERS, and Now COVID-19 Severe acute respiratory syndrome (SARS): epidemiology and clinical features Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission A novel coronavirus from patients with pneumonia in China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-toperson transmission: a study of a family cluster Responding to Covid-19-A once-in-a-century pandemic? Rational use of personal protective equipment for coronavirus disease 2019 (COVID-19) Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement The development of a critical appraisal tool for use in systematic reviews: addressing questions of prevalence Statistical aspects of the analysis of data from retrospective studies Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Early epidemiological analysis of the 2019-nCoV outbreak based on a crowdsourced data Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-Infected pneumonia in Wuhan Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 2019 novel coronavirus infection in China Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia.


id: cord-293691-ewerquin
author: Sauerhering, Lucie
date: 2020-07-02
extension: .txt
mime: text/plain
words: 3438
sentence: 146
flesch: 38
cache: cache/cord-293691-ewerquin.txt
txt: txt/cord-293691-ewerquin.txt
title:
  Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice

summary:
  Moreover, we for the first time provide evidence that CsA triggered the activation of an antiviral defense state in lung epithelial cells. These data indicate that CsA treatment mounts a distinct interferon-driven antiviral response in lung epithelial cells.


id: cord-275313-mfyff9ne
author: Modjarrad, Kayvon
title: Treatment strategies for Middle East respiratory syndrome coronavirus
date: 2016-01-01
extension: .txt
mime: text/plain
words: 3779
sentence: 128
flesch: 32
cache: cache/cord-275313-mfyff9ne.txt
txt: txt/cord-275313-mfyff9ne.txt
summary:
  Epidemiological update: Middle East respiratory syndrome coronavirus (MERS-CoV) From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia County Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Human-dromedary camel interactions and the risk of acquiring zoonotic Middle East respiratory syndrome coronavirus infection Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Evidence for camel-to-human transmission of MERS coronavirus Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Transmission among healthcare worker contacts with a Middle East respiratory syndrome patient in a single Korean centre Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Health-care associate transmission of Middle East Respiratory Syndrome Corona virus, MERS-CoV, in the Kingdom of Saudi Arabia Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach Estimation of MERS-coronavirus reproductive number and case fatality rate for the Spring 2014 Saudi Arabia outbreak: insights from publicly available data Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Treatment with interferon-alpha2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Combination therapy with lopinavir/ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report Ribavirin and interferon-alpha2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Oral ribavirin for the treatment of noninfluenza respiratory viral infections: a systematic review Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis The use of convalescent plasma to treat emerging infectious diseases: focus on Ebola virus disease A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Towards the prophylactic and therapeutic use of human neutralizing monoclonal antibodies for Middle East respiratory syndrome coronavirus (MERS-CoV) Evaluation of candidate vaccine approaches for MERS-CoV Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Nucleotide prodrug GS-5734 is a broad-spectrum filovirus inhibitor that providescomplete therapeutic protection against the development of Ebola virus disease (EVD) in infected non-human primates ID Week BioCryst announces Nature publication demonstrating efficacy of BCX4430 in a non-human primate model of filovirus infection Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus Design of potential RNAi (miRNA and siRNA) molecules for Middle East respiratory syndrome coronavirus (MERS-CoV) gene silencing by computational method Antiviral drugs specific for coronaviruses in preclinical development A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs Most recently, Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a novel cause of severe acute respiratory illness after first being identified in a Saudi Arabian patient in 2012


id: cord-281529-2rec51xg
author: Haagmans, Bart L
title: Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
date: 2013-12-17
extension: .txt
mime: text/plain
words: 4037
sentence: 156
flesch: 51
cache: cache/cord-281529-2rec51xg.txt
txt: txt/cord-281529-2rec51xg.txt
summary:
  Global Alert and Response (GAR): novel coronavirus infection-update Ecology, evolution and classifi cation of bat coronaviruses in the aftermath of SARS Close relative of human Middle East respiratory syndrome coronavirus in bat Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Genetic characterization of betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East Respiratory Syndrome Coronavirus Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Transmission scenarios for Middle East respiratory syndrome coronavirus (MERS-CoV) and how to tell them apart Recovery from severe novel coronavirus infection Family cluster of Middle East respiratory syndrome coronavirus infections Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Alert and Response (GAR): novel coronavirus infection-update Alert and Response (GAR): novel coronavirus infection-update Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confi rmation of novel human coronavirus (hCoV-EMC) infections SeaView version 4: a multiplatform graphical user interface for sequence alignment and phylogenetic tree building Specifi c serology for emerging human coronaviruses by protein microarray Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronavirus: data gaps for laboratory preparedness We thank WHO and the Food and Agriculture Organization of the United Nations for their generous help in organisation of the study, Theo Bestebroer for providing Middle East respiratory syndrome coronavirus specifi c primer sets, Berend Jan Bosch for providing antigens for the microarray, and Jeroen Cremer for technical support. Viral sequences from the two human cases were isolated (with the same techniques as for camel cases) in the Reference Department, Public Health England, London, UK.


id: cord-260518-mswb3q67
author: Zumla, Alimuddin
date: 2016-06-15
extension: .txt
mime: text/plain
words: 4040
sentence: 143
flesch: 36
cache: cache/cord-260518-mswb3q67.txt
txt: txt/cord-260518-mswb3q67.txt
title:
  Taking forward a ‘One Health’ approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential

summary:
  Since the Kingdom of Saudi Arabia is host to millions of pilgrims each year travelling from all continents, 29 tackling the threat of MERS and other infectious diseases with epidemic potential will require enhanced closer cooperation between those who provide human health, animal health, and environmental health services, locally, nationally, regionally, and internationally: the Middle Eastern, European, African, Asian, and American governments, veterinary groups, the WHO, the Food and Agriculture Organization (FAO), the African Union, the United Nations International Children's Emergency Fund (UNICEF), The World Bank, Office International des Epizooties (OIE), CDC, Public Health England, the newly formed Africa CDC, and funding agencies among others. However, MERS-CoV remains a major global public health threat with continuing reports of new human MERS cases in Saudi Arabia, where millions of pilgrims from over 184 countries travel throughout the year.


id: cord-293505-1t3hg4wi
author: Bernard-Stoecklin, Sibylle
date: 2019-05-14
extension: .txt
mime: text/plain
words: 4167
sentence: 156
flesch: 38
cache: cache/cord-293505-1t3hg4wi.txt
txt: txt/cord-293505-1t3hg4wi.txt
title:
  Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017

summary:
  Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. After Cardiac Operations An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Hospital outbreak of Middle East respiratory syndrome coronavirus Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia MERS outbreak in Korea: hospital-to-hospital transmission Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from MERS:


id: cord-284374-sqxlnk9e
author: Park, Jiyeon
date: 2020-01-15
extension: .txt
mime: text/plain
words: 4256
sentence: 169
flesch: 39
cache: cache/cord-284374-sqxlnk9e.txt
txt: txt/cord-284374-sqxlnk9e.txt
title:
  Infection Prevention Measures for Surgical Procedures during a Middle East Respiratory Syndrome Outbreak in a Tertiary Care Hospital in South Korea

summary:
  Moreover, there may be very few hospitals that are prepared to provide perioperative care for MERS patients. Almost all hospitals generally have positive-pressure operating rooms and they may experience an outbreak without facilities that are prepared for perioperative management of MERS patients, as our hospital did in 2015.


id: cord-271681-jmoyy8rb
author: Assiri, Abdullah M.
date: 2016-06-14
extension: .txt
mime: text/plain
words: 4376
sentence: 185
flesch: 40
cache: cache/cord-271681-jmoyy8rb.txt
txt: txt/cord-271681-jmoyy8rb.txt
title:
  Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

summary:
  Specimens and Molecular Testing at the MoH Respiratory specimens, including nasopharyngeal and oral pharyngeal swabs, both separate and combined, nasopharyngeal and tracheal aspirates, and sputa collected from suspected MERS cases were tested at MOH laboratories by upE and ORF1a rRT-PCR assays key: cord-271681-jmoyy8rb authors: Assiri, Abdullah M.; Midgley, Claire M.; Abedi, Glen R.; Saeed, Abdulaziz Bin; Almasri, Malak M.; Lu, Xiaoyan; Al-Abdely, Hail M.; Abdalla, Osman; Mohammed, Mutaz; Algarni, Homoud S.; Alhakeem, Raafat F.; Sakthivel, Senthilkumar K.; Nooh, Randa; Alshayab, Zainab; Alessa, Mohammad; Srinivasamoorthy, Ganesh; AlQahtani, Saeed Yahya; Kheyami, Ali; HajOmar, Waleed Husein; Banaser, Talib M.; Esmaeel, Ahmad; Hall, Aron J.; Curns, Aaron T.; Tamin, Azaibi; Alsharef, Ali Abraheem; Erdman, Dean; Watson, John T.; Gerber, Susan I. title: Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia date: 2016-06-14 journal: Journal of Infectious Diseases DOI: 10.1093/infdis/jiw236 sha: doc_id: 271681 cord_uid: jmoyy8rb BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans.


id: cord-018508-pk0ealu5
author: Hu, Yi
title: A Farewell to the “Sick Man of East Asia”: The Irony, Deconstruction, and Reshaping of the Metaphor
date: 2013-08-28
extension: .txt
mime: text/plain
words: 5105
sentence: 183
flesch: 51
cache: cache/cord-018508-pk0ealu5.txt
txt: txt/cord-018508-pk0ealu5.txt
summary:
  With their tacit understanding and informal networks, the peasants could help themselves without directly or symbolically fi ghting against the authority Report on Chinese people's voluntary army in the war to resist U.S. aggression and aid Korea Epidemics and history: Ecological perspectives and social responses Weapons of the weak: Everyday forms of peasant resistance Illness as metaphor Social history of diseases in modern China Guns, germs, and steel: The fates of human societies Suppression of U.S. germ warfare crimes.


id: cord-280350-ay4cnzn5
author: Chan, Jasper F.W.
title: Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus
date: 2013-10-03
extension: .txt
mime: text/plain
words: 5166
sentence: 168
flesch: 34
cache: cache/cord-280350-ay4cnzn5.txt
txt: txt/cord-280350-ay4cnzn5.txt
summary:
  73 Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic The emerging novel Middle East respiratory syndrome coronavirus: the knowns and unknowns Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV); announcement of the coronavirus study group Global alert and response: Middle East respiratory syndrome coronavirus (MERS-CoV) e update e as of 4 October Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features Genetic relatedness of the novel human lineage C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 Genetic characterization of Betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East Respiratory Syndrome Coronavirus Interspecies transmission and emergence of novel viruses: lessons from bats and birds Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Coronaviruses in bats from Mexico Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications on disease pathogenesis and clinical manifestation Human coronavirus EMC does not require the SARScoronavirus receptor and maintains broad replicative capability in mammalian cell lines Middle East respiratory syndrome coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Update: severe respiratory illness associated with middle East respiratory syndrome coronavirus (MERS-CoV) e Worldwide Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Family cluster of middle East respiratory syndrome coronavirus infections Hospital outbreak of middle East respiratory syndrome coronavirus A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case First cases of middle East respiratory syndrome coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Identification of influenza A nucleoprotein as an antiviral target Two years after pandemic influenza A/2009/H1N1: what have we learned? Avian influenza A H5N1 virus: a continuous threat to humans Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome The emergence of influenza A (H7N9) sixteen years after influenza A(H5N1) in humans: a tale of two cities Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Treatment of SARS with human interferons Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells Characterization of SARS-CoV main protease and identification of biologically active small molecule inhibitors using a continuous fluorescence-based assay Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin Mycophenolate mofetil: an update Identification of active antiviral compounds against a New York isolate of West Nile virus Mycophenolic acid inhibits replication of Japanese encephalitis virus The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells Antiviral or proviral action of mycophenolic acid in hepatitis B infection?


id: cord-252332-1aqi47jg
author: Gray, J. W.
title: HIS Middle East Infection Prevention Summit 2015
date: 2015-11-30
extension: .txt
mime: text/plain
words: 314
sentence: 11
flesch: 39
cache: cache/cord-252332-1aqi47jg.txt
txt: txt/cord-252332-1aqi47jg.txt
summary:
  Two of the themes of the conference that have particular international relevance are the huge challenges presented by multidrug-resistant Gram-negative bacteria in Middle Eastern hospitals, and local experience with Middle East respiratory syndrome coronavirus (MERS-CoV). 1e3 Middle East respiratory syndrome coronavirus (MERS-CoV); what lessons can we learn?


id: cord-278238-w1l8h8g8
author: Okba, Nisreen MA
title: Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches
date: 2017-04-13
extension: .txt
mime: text/plain
words: 5103
sentence: 178
flesch: 33
cache: cache/cord-278238-w1l8h8g8.txt
txt: txt/cord-278238-w1l8h8g8.txt
summary:
  key: cord-278238-w1l8h8g8 authors: Okba, Nisreen MA; Raj, V Stalin; Haagmans, Bart L title: Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches date: 2017-04-13 journal: Curr Opin Virol DOI: 10.1016/j.coviro.2017.03.007 sha: doc_id: 278238 cord_uid: w1l8h8g8 Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. Noteworthy to mention is Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches Okba, Raj and Haagmans 51 Ad/hDPP4-mice, mice transduced with hDPP4 in an adenoviral vector; alum, aluminum hydroxide; E, envelope protein; hDPP4, human dipeptidyl peptidase 4; i.m., intramuscular; i.n., intranasal; M, matrix protein; MERS-CoV, Middle East respiratory syndrome coronavirus; Nab, neutralizing antibodies; ND, not done; NHP, non-human primate; rNTD, recombinant N-terminal domain; RBD, receptor-binding domain; rRBD, recombinant RBD; RBD-Fc, RBD fused to the antibody crystallizable fragment of human IgG; S, spike protein; S1, S1 domain of spike protein; S367-606, amino acid residues 367-606 of the S protein; S736-761-KLH, peptide S736-761 coupled to keyhole limpet haemocyanin; s.c., subcutaneous; VLPs, Virus-like particles; a i.m.;alum/CpG ODN produced higher neutralizing antibody responses than s.c.; IFA/CpG ODN.


id: cord-016451-k8m2xz0e
author: Chertow, Daniel S.
title: Influenza, Measles, SARS, MERS, and Smallpox
date: 2020-01-03
extension: .txt
mime: text/plain
words: 6148
sentence: 284
flesch: 36
cache: cache/cord-016451-k8m2xz0e.txt
txt: txt/cord-016451-k8m2xz0e.txt
summary:
  The timeline of influenza virus shedding in children and adults in a household transmission study of influenza in Managua Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature Influenza virus-induced lung injury: pathogenesis and implications for treatment The pathology of influenza virus infections Bacterial coinfection in influenza: a grand rounds review Human infection with highly pathogenic avian influenza A(H7N9) virus, China Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif Immunobiology of influenza vaccines Airborne transmission of measles in a physician's office Measles virus host invasion and pathogenesis Pathological consequences of systemic measles virus infection Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques The clinical significance of measles: a review The basic reproduction number (R0) of measles: a systematic review Early waning of maternal measles antibodies in era of measles elimination: longitudinal study Measles virus-induced suppression of immune responses Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality Evidence of airborne transmission of the severe acute respiratory syndrome virus Model parameters and outbreak control for SARS Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Multiple organ infection and the pathogenesis of SARS Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Seasonal influenza virus infection is largely limited to the respiratory tract; however, H5 and H7 HPAI viruses have a polybasic cleave site within the hemagglutinin allowing for replication outside of the respiratory tract [65, 66] .


id: cord-252883-1ub01j2x
author: Bleibtreu, A.
title: Focus on Middle East respiratory syndrome coronavirus (MERS-CoV)
date: 2019-11-11
extension: .txt
mime: text/plain
words: 6235
sentence: 274
flesch: 47
cache: cache/cord-252883-1ub01j2x.txt
txt: txt/cord-252883-1ub01j2x.txt
summary:
  WHO Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study New case of MERS-CoV identified in the United Kingdom Middle East respiratory syndrome coronavirus (MERS-CoV): prevention in travelers Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Specific serology for emerging human coronaviruses by protein microarray Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015 Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea MERS-CoV outbreak in Jeddah-a link to health care facilities MERS outbreak in Korea: hospital-to-hospital transmission Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Middle East respiratory syndrome coronavirus infections in health care workers Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Hospital outbreak of middle east respiratory syndrome coronavirus Middle East respiratory syndrome A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes Rapid risk assessment: Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV), 22nd update Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus infection: a short note on cases with renal failure problem State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea IFN-(2a or IFN-(1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Viral RNA in blood as Indicator of Severe Outcome in Middle East Respiratory Syndrome Coronavirus Infection Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Prevention and treatment of respiratory viral infections: presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): a review Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study A review of treatment modalities for Middle East Respiratory Syndrome Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Treatment With Lopinavir/Ritonavir or Interferon-(1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Alisporivir inhibits MERS-and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona-and picornaviruses Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice The chapters on the origin, emergence, structure, transmission mechanisms, prevention and diagnostic methods were mainly written MB, NH, and BV.BV produced the figures. Consensus document on the epidemiology of severe acute respiratory syndrome (SARS) Molecular evolution of human coronavirus genomes Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Severe respiratory illness caused by a novel coronavirus WHO | Background and summary of novel coronavirus infection-as of 21 Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological stud Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia MERS coronavirus neutralizing antibodies in camels Antibodies against MERS coronavirus in dromedary camels Risk factors for MERS coronavirus infection in dromedary camels in Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein A structural analysis of M protein in coronavirus assembly and morphology East respiratory syndrome coronavirus (MERS-CoV)-update.


id: cord-018354-o6pmuhd8
author: Mine, Yoichi
title: Human Security in East Asia: Assembling a Puzzle
date: 2018-12-07
extension: .txt
mime: text/plain
words: 7429
sentence: 280
flesch: 41
cache: cache/cord-018354-o6pmuhd8.txt
txt: txt/cord-018354-o6pmuhd8.txt
summary:
  Human security is being formed as a norm-complex in which different existing norms are combined and nested under the umbrella of human security (Kurusu 2005) . The notion of human security is distinct from the responsibility to protect and its implementation, and (e) Human security does not entail the threat or the use of force or coercive measures and does not replace State security.


id: cord-264956-wbi0ird5
author: Ahmed, Anwar E.
date: 2018-04-14
extension: .txt
mime: text/plain
words: 2584
sentence: 103
flesch: 42
cache: cache/cord-264956-wbi0ird5.txt
txt: txt/cord-264956-wbi0ird5.txt
title:
  Development of a risk‐prediction model for Middle East respiratory syndrome coronavirus infection in dialysis patients

summary:
  MERS dialysis patients were more likely to have chest pain (OR 5 24.194; P 5 0.011), leukopenia (OR 5 6.080; P 5 0.049), and elevated AST (OR 5 11.179; P 5 0.013). The Youden index yielded a value of 0.439 or greater as the best cut‐off for high risk of MERS infection.


id: cord-273626-zy8qjaai
author: Gong, Shu‐ran
title: The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models
date: 2018-07-28
extension: .txt
mime: text/plain
words: 3259
sentence: 113
flesch: 45
cache: cache/cord-273626-zy8qjaai.txt
txt: txt/cord-273626-zy8qjaai.txt
summary:
  Regarding priorities for research on vaccines and antivirals for both coronaviruses, suitable MERS-CoV models should be considered first. 12M-006), the Chinese National Major S & T Project Wild animal surveillance for coronavirus HKU1 and potential variants of other coronaviruses Prevalence and genetic diversity of coronaviruses in bats from China Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Discovery of a rich gene pool of bat SARS related coronaviruses provides new insights into the origin of SARS coronavirus Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syn Rooting the phylogenetic tree of middle east respiratory syndrome coronavirus by characterization of a Conspecific virus from an African Bat Re-emerging Middle East respiratory syndrome coronavirus: The hibernating bat hypothesis Possible role of an animal vector in the SARS outbreak at Amoy Gardens Prevalence of IgG antibody to SARS-associated coronavirus in animal traders Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome Coronavirus isolates Comments to the predecessor of human SARS coronavirus in 2003-2004 epidemic Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Pneumonia from human coronavirus in a macaque model Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS Coronavirus Macaque Model for Severe Acute Respiratory Syndrome An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus Treatment With Lopinavir/Ritonavir or Interferon-b1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Pneumonitis and multiorgan system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of Mice Aged BALB/c Mice as a model for increased severity of severe acute respiratory syndrome in elderly humans Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian Hamsters Pathology of experimental SARS coronavirus infection in cats and ferrets Animal models for SARS Studies of severe acute respiratory syndrome coronavirus pathology in human cases and animal models Infection, replication, and transmission of middle east respiratory syndrome Coronavirus in Alpacas Replicative Capacity of MERS Coronavirus in Livestock Cell Lines Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses How to cite this article: Gong SR, Bao LL. key: cord-273626-zy8qjaai authors: Gong, Shu‐ran; Bao, Lin‐lin title: The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models date: 2018-07-28 journal:


id: cord-270258-9vgpphiu
author: Ko, Jae-Hoon
date: 2016-08-09
extension: .txt
mime: text/plain
words: 3461
sentence: 133
flesch: 38
cache: cache/cord-270258-9vgpphiu.txt
txt: txt/cord-270258-9vgpphiu.txt
title:
  Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients

summary:
  World Health Organization Case definition and management of patients with MERS coronavirus in Saudi Arabia MERS-CoV outbreak in Jeddah e a link to health care facilities On estimating the relation between blood group and disease Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Treatment strategies for Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV), US CDC Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong White cell differential count and influenza A Thrombocytopenia in patients with severe acute respiratory syndrome (review) The clinical course of symptomatic MERS patients progressed serially: patients developed initial symptoms after a median 5-day incubation period (IQR 3.5e7.0), pneumonia after a median of 6 days from symptom onset (IQR 5.0e7.0), and respiratory failure after a median of 12 days from symptom onset (IQR 10.0e13.0).


id: cord-269885-r8molh8c
author: Jeong, Soo Young
title: MERS-CoV Infection in a Pregnant Woman in Korea
date: 2017-08-08
extension: .txt
mime: text/plain
words: 1985
sentence: 80
flesch: 46
cache: cache/cord-269885-r8molh8c.txt
txt: txt/cord-269885-r8molh8c.txt
summary:
  The effect of Asian influenza on the outcome of pregnancy MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Middle East Respiratory Syndrome Coronavirus (MERS-CoV) nosocomial outbreak in South Korea: insights from modeling Interim infection prevention and control recommendations for hospitalized patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Serologic evaluation of MERS screening strategy for healthcare personnel during a hospital-associated outbreak Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Characteristics and outcomes of Middle East Respiratory Syndrome Coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical presentation and outcomes of Middle East Respiratory Syndrome in the Republic of Korea MERS outbreak in Korea: hospital-to-hospital transmission Better understanding on MERS Corona Virus outbreak in Korea Case definition and management of patients with MERS Coronavirus in Saudi Arabia Impact of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) on pregnancy and perinatal outcome Middle East Respiratory Syndrome Coronavirus infection during pregnancy: a report of 5 cases from Saudi Arabia Middle East Respiratory Syndrome Coronavirus during pregnancy Stillbirth during infection with Middle East Respiratory Syndrome Coronavirus Transmission of MERS-coronavirus in household contacts Persistence of antibodies against Middle East Respiratory Syndrome Coronavirus Middle East Respiratory Syndrome Coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control The emergence of the Middle East Respiratory Syndrome Coronavirus We thank Dr. Christian Drosten and Dr. Marcel A. Muller in Institute of Virology, University of Bonn Medical Center for performing immunoglobulin A (IgA) enzyme-linked immunosorbent assay (ELISA) and plaque reduction neutralization test (PRNT). After a full recovery of MERS, the patient manifested abrupt vaginal bleeding with rupture of membrane.


id: cord-284581-fl2nt4ak
author: Kleine-Weber, Hannah
date: 2019-07-19
extension: .txt
mime: text/plain
words: 3207
sentence: 98
flesch: 42
cache: cache/cord-284581-fl2nt4ak.txt
txt: txt/cord-284581-fl2nt4ak.txt
title:
  Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells

summary:
  In order to study host cell entry driven by S proteins from the C1 subclade, we employed PCR-based mutagenesis to generate expression constructs for the S proteins of MERS-CoV from Morocco (camel/Morocco/CIRAD-HKU213/2015, MO), Nigeria (camel/Nigeria/NV1657/ 2016, NI) and Burkina Faso (camel/Burkina Faso/CIRAD-HKU785/ 2015, BF), using a published expression construct for MERS-CoV EMC S protein as template (Kleine-Weber et al., 2018 . S proteins of North/West-and West-African MERS-CoV isolates from dromedary camels efficiently bind to DPP4.


id: cord-255488-nvgz53su
author: Li, Kun
title: Development of a Mouse-Adapted MERS Coronavirus
date: 2019-09-14
extension: .txt
mime: text/plain
words: 2949
sentence: 169
flesch: 58
cache: cache/cord-255488-nvgz53su.txt
txt: txt/cord-255488-nvgz53su.txt
summary:
  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Person-toperson spread of the MERS coronavirus-an evolving picture The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Spread of MERS to South Korea and China Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East respiratory syndrome coronavirus (MERS-CoV) Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Pathogenicity and viral shedding of MERS-CoV in immunocompromised rhesus macaques Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Infection with MERS-CoV causes lethal pneumonia in the common marmoset Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East Coronavirus DOI: 10.1007/978-1-0716-0211-9_13 sha: doc_id: 255488 cord_uid: nvgz53su First identified in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that can cause acute respiratory distress syndrome (ARDS), multiorgan failure, and death, with a case fatality rate of ~35%.


id: cord-265666-27ckjl7w
author: Kang, Hee Sun
title: Working experiences of nurses during the Middle East respiratory syndrome outbreak
date: 2018-05-30
extension: .txt
mime: text/plain
words: 3134
sentence: 154
flesch: 53
cache: cache/cord-265666-27ckjl7w.txt
txt: txt/cord-265666-27ckjl7w.txt
summary:
  We made a package for MERS patients, a package for MERS. The hospitals rewarded working with MERS patients differently.


id: cord-291367-rtmsrh16
author: Zumla, Alimuddin
date: 2015-07-02
extension: .txt
mime: text/plain
words: 2263
sentence: 69
flesch: 36
cache: cache/cord-291367-rtmsrh16.txt
txt: txt/cord-291367-rtmsrh16.txt
title:
  Middle East Respiratory Syndrome - need for increased vigilance and watchful surveillance for MERS-CoV in sub-Saharan Africa

summary:
  -Saudi Arabia The Hajj pilgrimage and surveillance for Middle East Respiratory syndrome coronavirus in pilgrims from African countries High prevalence of common respiratory viruses and no evidence of Middle East Respiratory Syndrome Coronavirus in Hajj pilgrims returning to Ghana Hajj: infectious disease surveillance and control Travel implications of emerging coronaviruses: SARS and MERS-CoV Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program An update on Middle East respiratory syndrome: 2 years later Pilgrims and MERS-CoV: what's the risk? KSA MERS-CoV Investigation Team. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle East Respiratory Syndromeadvancing the public health and research agenda on MERS-lessons from the South Korea outbreak Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers Infection prevention and control of epidemic-and pandemicprone acute respiratory infections in health care -WHO Guidelines.


id: cord-263508-row2mn17
author: Chan, Jasper Fuk-Woo
title: The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns”
date: 2013-07-21
extension: .txt
mime: text/plain
words: 4349
sentence: 118
flesch: 27
cache: cache/cord-263508-row2mn17.txt
txt: txt/cord-263508-row2mn17.txt
summary:
  Announcement of the Coronavirus Study Group Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Latest outbreak news from ProMED-mail: novel coronavirus e Middle East Recovery from severe novel coronavirus infection Evidence of person-to-person transmission within a family cluster of novel coronavirus infections Contact investigation of a case of human novel coronavirus infection treated in a German hospital World Health Organization. Geneva: WHO Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Crossreactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Laboratory capability for molecular detection and confirmation of novel coronavirus in Europe Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC Global alert and response (GAR): Middle East respiratory syndrome coronavirus (MERS-CoV) e update


id: cord-268879-ajd7ofc8
author: Hui, David S.
title: Contemporary Concise Review 2018: Respiratory infections and tuberculosis
date: 2019-03-30
extension: .txt
mime: text/plain
words: 3697
sentence: 142
flesch: 32
cache: cache/cord-268879-ajd7ofc8.txt
txt: txt/cord-268879-ajd7ofc8.txt
summary:
  25 Social inequities continue to hamper TB control in many parts of the world, and major gaps remain in reaching, diagnosing and effectively treating TB patients, especially in resource-limited settings. In another longitudinal study from the same locality, 42 metformin users were associated with 44% reduction in mortality during TB treatment despite their higher haemoglobin A1c level.


id: cord-272513-umuiovrd
author: Bindayna, Khalid Mubarak
title: Variant analysis of SARS-CoV-2 genomes in the Middle East
date: 2020-10-09
extension: .txt
mime: text/plain
words: 3034
sentence: 159
flesch: 54
cache: cache/cord-272513-umuiovrd.txt
txt: txt/cord-272513-umuiovrd.txt
summary:
  key: cord-272513-umuiovrd authors: Bindayna, Khalid Mubarak; Crinion, Shane title: Variant analysis of SARS-CoV-2 genomes in the Middle East date: 2020-10-09 journal: bioRxiv DOI: 10.1101/2020.10.09.332692 sha: doc_id: 272513 cord_uid: umuiovrd Background Coronavirus (COVID-19) was introduced into society in late 2019 and has now reached over 26 million cases and 850,000 deaths. If we explore the structure and common variants of SARS-CoV-2 strains in these populations, we expect to learn more about how the virus spread.


id: cord-288389-z0sz1msj
author: Fanoy, Ewout B
date: 2014-10-17
extension: .txt
mime: text/plain
words: 2978
sentence: 141
flesch: 53
cache: cache/cord-288389-z0sz1msj.txt
txt: txt/cord-288389-z0sz1msj.txt
title:
  Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia, May 2014

summary:
  bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin Investigation of an imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in A case of imported Middle East respiratory syndrome coronavirus infection and public health response Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Geographic distribution of MERS coronavirus among dromedary camels Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Human infection with MERS coronavirus after exposure to infected camels Antibodies against MERS coronavirus in dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands World Health Organization: Twelve non-cases drank unpasteurized camel milk and had contact with camels.


id: cord-263016-28znb322
author: Omrani, A.S.
title: Middle East respiratory syndrome coronavirus (MERS-CoV): what lessons can we learn?
date: 2015-08-22
extension: .txt
mime: text/plain
words: 4493
sentence: 193
flesch: 41
cache: cache/cord-263016-28znb322.txt
txt: txt/cord-263016-28znb322.txt
summary:
  What travel health advice should be given to Hajj pilgrims Preventive measures against MERS-CoV for Hajj pilgrims The Hajj pilgrimage and surveillance for Middle East respiratory syndrome coronavirus in pilgrims from African countries Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj From the Hajj: it's the flu, idiot High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Circulation of respiratory viruses among pilgrims during the 2012 Hajj pilgrimage Saudi Arabia, South Korea Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Lessons to learn from MERS-CoV outbreak in South Korea Spread of MERS to South Korea and China List of hospitals with known MERS exposure Preliminary data from sequencing of viruses in the Republic of Korea and the People's Republic of China. Archive Number Severe respiratory illness caused by a novel coronavirus First cases of Middle East respiratory syndrome coronavirus (MERS-CoV) investigations and implications for the prevention of human-to-human transmission A case of imported Middle East respiratory syndrome coronavirus infection and public health response Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Lack of transmission among close contacts of patient with case of Middle East respiratory syndrome imported into the United States Spread, circulation, and evolution of the Middle East


id: cord-256806-g42n51n9
author: Khudhair, Ahmed
date: 2019-05-17
extension: .txt
mime: text/plain
words: 4412
sentence: 154
flesch: 38
cache: cache/cord-256806-g42n51n9.txt
txt: txt/cord-256806-g42n51n9.txt
title:
  Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014–2017

summary:
  Previous studies of workers with occupational exposure to camels have reported either lower seropositivity rates (e.g., 6.8% of 294 workers with occupational camel contact seropositive in Qatar [21] and 2.3% of 87 camel shepherds seropositive in Saudi Arabia [20] ) or comparable seropositivity (e.g., 53% of camel workers positive in Saudi Arabia [22] ). WHO MERS-CoV global summary and assessment of risk Middle East respiratory syndrome coronavirus (MERS-CoV) origin and animal reservoir Middle East respiratory syndrome coronavirus (MERS-CoV): animal to human interaction Risk factors for MERS coronavirus infection in dromedary camels in MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Antibodies against MERS coronavirus in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Risk factors for primary Middle East Respiratory syndrome coronavirus illness in humans, Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Occupational exposure to dromedaries and risk for MERS-CoV infection High prevalence of MERS-CoV infection in camel workers in Saudi Arabia Inovio Pharmaceuticals I. Inovio's MERS vaccine generates high levels of antibodies and induces broad-based T Cell responses in phase 1 study Man in Germany dies of complications stemming from Mers virus Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Korean Society of Infectious Diseases.


id: cord-252222-wyamc46k
author: Leung, Chi Hung Czarina
title: Middle East respiratory syndrome
date: 2014-05-13
extension: .txt
mime: text/plain
words: 1180
sentence: 70
flesch: 49
cache: cache/cord-252222-wyamc46k.txt
txt: txt/cord-252222-wyamc46k.txt
summary:
  Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Emerging human Middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Middle East respiratory syndrome: new disease, old lessons Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids Assessing the pandemic potential of MERS-CoV key: cord-252222-wyamc46k authors: Leung, Chi Hung Czarina; Gomersall, Charles David title: Middle East respiratory syndrome date: 2014-05-13 journal: Intensive Care Med DOI: 10.1007/s00134-014-3303-y sha: doc_id: 252222 cord_uid: wyamc46k nan Middle East respiratory syndrome (MERS) is due to RNA betacoronavirus (MERS-CoV) infection.


id: cord-017615-zjr6csla
author: Hillman, John R.
title: Food Security in an Insecure Future
date: 2016-11-25
extension: .txt
mime: text/plain
words: 9985
sentence: 354
flesch: 32
cache: cache/cord-017615-zjr6csla.txt
txt: txt/cord-017615-zjr6csla.txt
summary:
  Poor countries are usually unable to defend themselves from terrorists, and groups of terrorists may receive covert support from other countries and agencies. Poor countries may form the battlefield for fighting between different groups of terrorists.


id: cord-297062-dmiplvt2
author: Almekhlafi, Ghaleb A.
title: Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients
date: 2016-05-07
extension: .txt
mime: text/plain
words: 4410
sentence: 203
flesch: 45
cache: cache/cord-297062-dmiplvt2.txt
txt: txt/cord-297062-dmiplvt2.txt
summary:
  Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Acute management and long-term survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS APACHE II: a severity of disease classification system The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Interestingly, Acinetobacter baumannii, which is an emerging fatal infection in ICU patients worldwide, was isolated from deep tracheal aspirates in one in four patients.


id: cord-271004-gtmo5ixs
author: Al-Tawfiq, Jaffar A.
date: 2017-10-12
extension: .txt
mime: text/plain
words: 2645
sentence: 116
flesch: 49
cache: cache/cord-271004-gtmo5ixs.txt
txt: txt/cord-271004-gtmo5ixs.txt
title:
  Influenza is more common than Middle East Respiratory Syndrome Coronavirus (MERS-CoV) among hospitalized adult Saudi patients

summary:
  4. Interval plot of age and 95% confidence interval of age among influenza patients Hematologic, hepatic, and renal function changes in hospitalized patients with Middle East respiratory syndrome coronavirus Surveillance and testing for Middle East respiratory syndrome coronavirus Evaluation of patients under investigation for MERS-CoV infection Response to emergence of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Patterns of human respiratory viruses and lack of MERS-coronavirus in patients with acute upper respiratory tract infections in southwestern province of Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region Description of a hospital outbreak of Middle East respiratory syndrome in a large tertiary care hospital in Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study Influenza activity -United States, 2015-16 season and composition of the 2016-17 influenza vaccine Cross-Sectional survey and surveillance for influenza viruses and MERS-CoV among egyptian pilgrims returning from Hajj during 2012-2015 Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travellers and pilgrims from the Middle East: a prospective descriptive study for the period 2013-2015 Influenza not MERS CoV among returning Hajj and Umrah pilgrims with respiratory illness Hajj-associated viral respiratory infections: a systematic review Influenza A and B viruses but not MERS-CoV in Hajj pilgrims Laboratory testing for Middle East respiratory syndrome coronavirus Interim Guidelines for Clinical Specimens from PUI | CDC n The impact of coinfection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus Pandemic influenza A (2009 H1N1) in hospitalized patients in a Saudi Arabian hospital: epidemiology and clinical comparison with H1N1-negative patients Differences in clinical features between influenza A H1N1, A H3N2, and B in adult patients Clinical differences between influenza A (H1N1) pdm09 & influenza B infections identified through active community surveillance in North India Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Infections in symptomatic travelers returning from the Arabian peninsula to France: a retrospective cross-sectional study Enhanced MERS coronavirus surveillance of travelers from the Middle East to England Acute respiratory infections in travelers returning from MERS-CoV-affected areas All authors have no conflict of interest to declare. WHO Family cluster of Middle East respiratory syndrome coronavirus infections Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Recovery from severe novel coronavirus infection Saudi Ministry of Health C and CC.


id: cord-274591-p34kk4up
author: Horby, Peter W,
date: 2013-06-17
extension: .txt
mime: text/plain
words: 4268
sentence: 119
flesch: 27
cache: cache/cord-274591-p34kk4up.txt
txt: txt/cord-274591-p34kk4up.txt
title:
  Prospects for Emerging Infections in East and Southeast Asia 10 Years after Severe Acute Respiratory Syndrome

summary:
  It is 10 years since severe acute respiratory syndrome (SARS) emerged, and East and Southeast Asia retain a reputation as a hot spot of emerging infectious diseases. These changes might facilitate the emergence and transmission of new pathogens, but it would be simplistic and disingenuous to present the extensive changes in East and Southeast Asia as inevitably increasing the risk of emerging infectious diseases.


id: cord-275602-cog4nma0
author: Watkins, Kevin
title: Emerging Infectious Diseases: a Review
date: 2018-06-22
extension: .txt
mime: text/plain
words: 4676
sentence: 255
flesch: 47
cache: cache/cord-275602-cog4nma0.txt
txt: txt/cord-275602-cog4nma0.txt
summary:
  Emerging infectious diseases: a CDC perspective Emerging infectious diseases in 2012: 20 years after the Institute of Medicine Report Emerging infectious disease: a proactive approach A novel coronavirus associated with severe acute respiratory syndrome Severe acute respiratory syndrome (SARS): a review of the history, epidemiology, prevention, and concerns for the future Severe acute respiratory syndrome and coronavirus Severe acute respiratory syndrome (SARS) Severe acute respiratory syndrome and influenza: virus incursions from southern China WHO guidelines for the global surveillance of severe acute respiratory syndrome (SARS) Anti-SARS coronavirus agents: a patent review (2008-present) Middle East respiratory syndrome coronavirus: a comprehensive review Middle East respiratory syndrome: what clinicians need to know Middle East respiratory syndrome coronavirus: update for clinicians This article gives the majority of a summary of perhaps most significant recent emerging infectious disease in terms of both mortality and number of cases Middle East respiratory syndrome coronavirus disease is rare in children: an update from Saudi Arabia Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Infection Prevention and Control Guidelines for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus A review of treatment modalities for Middle East respiratory syndrome Treatment outcomes for patients with middle eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia A new Phlebovirus associated with severe febrile illness in Missouri Notes from the field: heartland virus disease-United States Heartland virus associated death in Tennessee Update and commentary on four emerging tick-borne infections Novel Thogotovirus associated with febrile illness and death Bourbon virus in field-collected ticks Nipah encephalitis-an update The pandemic potential of Nipah virus Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody Emergomyces canadensis, a dimorphic fungus causing fatal systemic human disease in North America Emergomyces: a new genus of dimorphic fungal pathogens causing disseminated disease among immunocompromised persons globally Global spread of antibiotic resistance: the example of New Delhi metallo-ß-lactamase (NDM)-mediated carbapenem resistance The new medical challenge: why NDM-1? The Centers for Disease Control and Prevention (CDC) recommends evaluation for patients with respiratory symptoms and travel to an affected country within 14 days or for those who are in a cluster of patients with severe acute respiratory disease in which MERS-CoV is being evaluated [14] .


id: cord-277781-v9hw1cdi
author: Ejima, Keisuke
date: 2014-04-07
extension: .txt
mime: text/plain
words: 4428
sentence: 154
flesch: 38
cache: cache/cord-277781-v9hw1cdi.txt
txt: txt/cord-277781-v9hw1cdi.txt
title:
  Probabilistic differential diagnosis of Middle East respiratory syndrome (MERS) using the time from immigration to illness onset among imported cases

summary:
  This indicates that the high probability of influenza would not be the case even for those developing illness in 2 days if MERS transmission was more widespread than influenza or if the cases were at high risk of MERS (e.g. with suspected exposure to camels or other MERS cases in hospital) (Assiri et al., 2013b; Reusken et al., 2013a It should also be emphasized that the viral etiological study is valuable to directly quantify q i based on empirical data, although such data may be only applicable to general travelers (and not the travelers with close contact with other MERS cases or animals (Nishiura et al., 2014) ).


id: cord-286472-pqtem19t
author: McFee, R.B.
title: MIDDLE EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS
date: 2020-07-28
extension: .txt
mime: text/plain
words: 5367
sentence: 207
flesch: 40
cache: cache/cord-286472-pqtem19t.txt
txt: txt/cord-286472-pqtem19t.txt
summary:
  Of note, co-infection with other respiratory viruses and a few cases of co-infection with communityacquired bacteria at admission has been reported in MERS CoV patients. Patients recently returning from the Middle East, presenting with significant respiratory illness, with CT findings of peribronchial region abnormalities, organizing pneumonia, should be considered for MERS CoV infection, and if possible, queried about international travel and occupational exposures.


id: cord-262542-vevsgkp6
author: Alharbi, Naif Khalaf
date: 2017-06-27
extension: .txt
mime: text/plain
words: 4957
sentence: 203
flesch: 45
cache: cache/cord-262542-vevsgkp6.txt
txt: txt/cord-262542-vevsgkp6.txt
title:
  ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice

summary:
  All vaccines contained the full-length spike gene of MERS-CoV; ChAdOx1 MERS vaccines were produced with or without the leader sequence of the human tissue plasminogen activator gene (tPA) where MVA MERS vaccines were produced with tPA, but either the mH5 or F11 promoter driving expression of the spike gene. For MVA MERS vaccines chicken embryo fibroblast cells (CEFs) were infected with MVA parental virus that encodes dsRed marker instead of the native F11L ORF and transfected with MVA shuttle plasmids containing MERS-CoV spike gene (explained above) to allow recombination with the MVA genome and deletion of dsRed marker whilst keeping the F11 promoter sequence.


id: cord-290319-decr6wrd
author: Kayali, Ghazi
title: A more detailed picture of the epidemiology of Middle East respiratory syndrome coronavirus
date: 2015-05-31
extension: .txt
mime: text/plain
words: 1621
sentence: 53
flesch: 42
cache: cache/cord-290319-decr6wrd.txt
txt: txt/cord-290319-decr6wrd.txt
summary:
  One concern with school-based programmes is the Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional serological study Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia MERS-CoV): summary of current situation, literature update and risk assessment Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Close relative of human Middle East respiratory syndrome coronavirus in bat MERS-Related Betacoronavirus in Vespertilio Superans bats Middle East respiratory syndrome: An emerging coronavirus infection tracked by the crowd MERS coronaviruses in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Investigation of anti-middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, fall 2012 Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 Lack of Middle East respiratory syndrome coronavirus transmission from infected camels Acute Middle East respiratory syndrome coronavirus infection in livestock dromedaries Evidence is accumulating that dromedary camels are a natural host of MERS-CoV. Serological fi ndings suggest that more than 90% of adult dromedaries in the Middle East and Africa are seropositive for MERS-CoV. 7 The virus isolated from dromedaries has spike proteins with conserved receptor-binding domains for the human dipeptidyl peptidase-4 receptor, 8, 9 and MERS-CoV has been detected in camels that were in close contact with people with Middle East respiratory syndrome.


id: cord-265380-2gs34xcw
author: Leist, Sarah R.
date: 2019-09-14
extension: .txt
mime: text/plain
words: 6031
sentence: 299
flesch: 46
cache: cache/cord-265380-2gs34xcw.txt
txt: txt/cord-265380-2gs34xcw.txt
title:
  Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome

summary:
  After infection mice are monitored daily for weight loss for the entire duration of the experiment. The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts Comparative analysis of eleven healthcare-associated outbreaks of Middle East respiratory syndrome coronavirus (Mers-Cov) from Economic impact of the 2015 MERS outbreak on the Republic of Korea's tourism-related industries Costly lessons from the 2015 Middle East respiratory syndrome coronavirus outbreak in Korea Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission Middle East respiratory syndrome coronavirus transmission among health care workers: implication for infection control MERS transmission and risk factors: a systematic review High prevalence of MERS-CoV infection in camel workers in Saudi Arabia Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Severe acute respiratory syndrome Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice Origin and evolution of pathogenic coronaviruses Jumping species-a mechanism for coronavirus persistence and survival Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection-clinicopathological and ultrastructural study Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Middle East respiratory syndrome Viral load kinetics of MERS coronavirus infection The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Lack of Middle East respiratory syndrome coronavirus transmission in rabbits Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Pneumonia from human coronavirus in a macaque model Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Infection with MERS-CoV causes lethal pneumonia in the common marmoset A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Middle East Respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with Middle East respiratory syndrome-coronavirus Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to Middle East respiratory syndrome coronavirus infection and disease CD8+ T cells and macrophages regulate pathogenesis in a mouse model of Middle East respiratory syndrome A human DPP4-Knockin Mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with Middle East respiratory syndrome coronavirus Haagmans BL (2013)


id: cord-298941-xf2ukinp
author: Al-Abdallat, Mohammad Mousa
date: 2014-05-14
extension: .txt
mime: text/plain
words: 4829
sentence: 198
flesch: 38
cache: cache/cord-298941-xf2ukinp.txt
txt: txt/cord-298941-xf2ukinp.txt
title:
  Hospital-Associated Outbreak of Middle East Respiratory Syndrome Coronavirus: A Serologic, Epidemiologic, and Clinical Description

summary:
  Sera from the 2 fatal cases (designated outbreak subjects 01 and 12) having positive rRT-PCR tests were also tested by the 3 described serology tests. The recombinant btHKU5.2 nucleocapsid proteinbased ELISA was developed by the CDC to detect the presence of antibodies that cross-react with the HKU5.2 N protein in serum samples from possible MERS cases.


id: cord-268943-arjtjy53
author: Reuss, Annicka
title: Contact Investigation for Imported Case of Middle East Respiratory Syndrome, Germany
date: 2014-04-17
extension: .txt
mime: text/plain
words: 3059
sentence: 111
flesch: 41
cache: cache/cord-268943-arjtjy53.txt
txt: txt/cord-268943-arjtjy53.txt
summary:
  These findings suggest these animals' possible relevance (e.g., as intermediate hosts) for human acquisition of MERS-CoV. Two complementary monitoring instruments for contact persons were used: active follow-up with daily telephone contact and a self-administered monitoring questionnaire. Such a questionnaire could be expanded to include a section for contact persons to fill in the names of persons with whom they had face-to-face contact during each day.


id: cord-266260-t02jngq0
author: Ramshaw, Rebecca E.
title: A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences
date: 2019-12-13
extension: .txt
mime: text/plain
words: 7243
sentence: 243
flesch: 30
cache: cache/cord-266260-t02jngq0.txt
txt: txt/cord-266260-t02jngq0.txt
summary:
  Vector Borne Zoonotic Dis Arabia: an index case investigation Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Stillbirth During Infection With Middle East Respiratory Syndrome Coronavirus Antibodies against MERS Coronavirus in Dromedary Camels MERS-CoV Antibodies in Humans, Africa No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection Among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update Emergence of MERS-CoV in the Middle East: origins, transmission, treatment, and perspectives Laboratory-confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Malaysia: preparedness and response Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Asymptomatic MERS-CoV Infection in Humans Possibly Linked to Infected Dromedaries Imported from Oman to United Arab Emirates Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels The Middle East Respiratory Syndrome Coronavirus (MERS-COV) Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand Serologic Evidence for MERS-CoV Infection in Dromedary Camels Contact tracing the first Middle East respiratory syndrome case in the Philippines Effectiveness of the Middle East respiratory syndrome-coronavirus protocol in enhancing the function of an Emergency Department in Qatar High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Isolation of MERS coronavirus from a dromedary camel MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study MERS-CoV outbreak in Jeddah-a link to health care facilities A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS Acute Middle East Respiratory Syndrome Coronavirus: Temporal Lung Changes Observed on the Chest Radiographs of 55 Patients Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Antibody Response and Disease Severity in Healthcare Worker MERS Survivors Brief Report: Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a singlecenter experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Evidence for camel-to-human transmission of MERS coronavirus Exposures among MERS Case-Patients First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome Lack of middle East respiratory syndrome coronavirus transmission from infected camels Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East A cluster analysis with implications for global management of suspected cases Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Middle East respiratory syndrome coronavirus in children Middle East Respiratory Syndrome Coronavirus Infection During Pregnancy: A Report of 5 Cases From Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia Outbreak of Middle East Respiratory Syndrome at Tertiary Care Hospital Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Report of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in Four Patients with Hematological Malignancies Treated at King Fahad Medical City Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Healthcare Personnel Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report Surveillance and Testing for Middle East Respiratory Syndrome Coronavirus, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus transmission among health care workers: Implication for infection control Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Conveyance Contact Investigation for Imported Middle East Respiratory Syndrome Cases Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Outbreak of Middle East Respiratory Syndrome-Coronavirus Causes


id: cord-300536-8okuomi6
author: Baloch, Zulqarnain
title: Unique Challenges to Control the Spread of COVID-19 in the Middle East
date: 2020-07-13
extension: .txt
mime: text/plain
words: 1944
sentence: 83
flesch: 41
cache: cache/cord-300536-8okuomi6.txt
txt: txt/cord-300536-8okuomi6.txt
summary:
  This could reflect the levels of preparedness and response plans implemented locally in Middle East countries. Although the case number was low cases in the early days of the outbreak, it has speeded at unprecedented pace later on and affecting all the Middle East countries (Figure 1 ).


id: cord-295633-vkjcheaz
author: Hao, Xin‐yan
date: 2019-10-30
extension: .txt
mime: text/plain
words: 5112
sentence: 177
flesch: 41
cache: cache/cord-295633-vkjcheaz.txt
txt: txt/cord-295633-vkjcheaz.txt
title:
  The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device

summary:
  Vector Borne Zoonotic Dis Intranasal influenza infection of mice and methods to evaluate progression and outcome Comparison of traditional intranasal and aerosol inhalation inoculation of mice with influenza A viruses A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Mouseadapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Distribution of aerosols in mouse lobes by fluorescent imaging Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with middle east respiratory syndrome-coronavirus An acute immune response to Middle East respiratory syndrome coronavirus replication contributes to viral pathogenicity Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis SARS and other coronaviruses as causes of pneumonia Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Association between severity of MERS-CoV infection and incubation period Clinical implication of radiographic scores in acute Middle East respiratory syndrome coronavirus pneumonia: report from a single tertiary-referral center of South Korea Mortality rate of ICU patients with the Middle East respiratory syndrome -coronavirus infection at King Fahad Hospital Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 A human DPP4-Knockin mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV One Health Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC A rapid scoping review of Middle East respiratory syndrome coronavirus in animal hosts Clinical and biological character in mouse models for Middle East respiratory syndrome generated by transduction with different doses of DPP4 molecule Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to Middle East respiratory syndrome coronavirus infection and disease Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with Middle East respiratory syndrome coronavirus Emergencies preparedness, response.


id: cord-313737-cob5hf5q
author: Otter, J. A.
title: The inaugural Healthcare Infection Society Middle East Summit: ‘No action today. No cure tomorrow.’
date: 2015-11-30
extension: .txt
mime: text/plain
words: 1672
sentence: 79
flesch: 48
cache: cache/cord-313737-cob5hf5q.txt
txt: txt/cord-313737-cob5hf5q.txt
summary:
  Valerie Harmon delivered a useful lecture on achieving hand hygiene compliance. The problem with using human beings to monitor hand hygiene compliance is that the moment another person is there, compliance improves!


id: cord-304057-d2r92nji
author: Harrath, Rafik
date: 2018-04-26
extension: .txt
mime: text/plain
words: 1488
sentence: 51
flesch: 43
cache: cache/cord-304057-d2r92nji.txt
txt: txt/cord-304057-d2r92nji.txt
title:
  Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia

summary:
  These results may provide evidence that MERS‐CoV has previously infected dromedary camels in Tabuk and may support the possible role of camels in the human infection. key: cord-304057-d2r92nji authors: Harrath, Rafik; Abu Duhier, Faisel M. title: Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia date: 2018-04-26 journal: J Med Virol DOI: 10.1002/jmv.25186 sha: doc_id: 304057 cord_uid: d2r92nji The Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012.


id: cord-305773-ikm1famj
author: Lan, Bowen
title: Clinical imaging research of the first Middle East respiratory syndrome in China
date: 2015-11-23
extension: .txt
mime: text/plain
words: 1633
sentence: 70
flesch: 53
cache: cache/cord-305773-ikm1famj.txt
txt: txt/cord-305773-ikm1famj.txt
summary:
  Based on the first case of Middle East respiratory syndrome found in China, a clinical research in combination with radiological findings was studied. Middle East respiratory syndrome (MERS), also known as camel flu, is a viral respiratory illness caused by a novel human beta-coronavirus (CoV)


id: cord-293403-o1i999hy
author: Holliday, Ian
title: E-health in the East Asian tigers
date: 2004-09-11
extension: .txt
mime: text/plain
words: 6841
sentence: 349
flesch: 50
cache: cache/cord-293403-o1i999hy.txt
txt: txt/cord-293403-o1i999hy.txt
summary:
  Economic, organizational, legal, regulatory, and cultural conflicts rooted in the US healthcare system are all barriers to e-healthcare provision. It describes five main dimensions of e-health provision in the tigers: policymaking, regulation, provision, funding and physician-patient relations.


id: cord-299720-f0ny4ur5
author: Kim, Seung Woo
date: 2017-03-01
extension: .txt
mime: text/plain
words: 3916
sentence: 190
flesch: 45
cache: cache/cord-299720-f0ny4ur5.txt
txt: txt/cord-299720-f0ny4ur5.txt
title:
  Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea

summary:
  Spreaders were defined as confirmed cases of MERS-CoV infection that were epidemiologically suspected of transmitting MERS-CoV to 1 or more persons. [15] , which include persons who stayed in a room or ward with a confirmed case, who directly contacted respiratory secretions from confirmed cases, or who stayed within 2 m from the confirmed cases without wearing appropriate personal protective equipment.


id: cord-311937-6hadssmh
author: Sherbini, Nahid
date: 2016-06-11
extension: .txt
mime: text/plain
words: 2860
sentence: 141
flesch: 49
cache: cache/cord-311937-6hadssmh.txt
txt: txt/cord-311937-6hadssmh.txt
title:
  Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data

summary:
  Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 Family cluster of Middle East respiratory syndrome coronavirus infections Prevalence of diabetes mellitus in a Saudi community Severe acute respiratory syndrome and coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection A major outbreak of severe acute respiratory syndrome in Hong Kong Clinical and laboratory features in the early stage of severe acute respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings This study did not receive funding. This study describes the clinical characteristics and outcome of MERS infected patients.


id: cord-320746-iuzfexig
author: Rasmussen, Sonja A.
title: Middle East Respiratory Syndrome Coronavirus: Update for Clinicians
date: 2015-02-20
extension: .txt
mime: text/plain
words: 2391
sentence: 83
flesch: 37
cache: cache/cord-320746-iuzfexig.txt
txt: txt/cord-320746-iuzfexig.txt
summary:
  Coronavirus infections-disease oubreak news Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Middle East respiratory syndrome coronavirus disease in children State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Enhanced MERS coronavirus surveillance of travelers from the Middle East to England Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Middle East respiratory syndrome (MERS): information for health providers Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus An observational, laboratorybased study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus: implications for health care facilities Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus infections in health care workers Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Acknowledgments.


id: cord-317403-1wrsuoy7
author: Yang, Jeong-Sun
title: Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015
date: 2015-11-17
extension: .txt
mime: text/plain
words: 1477
sentence: 53
flesch: 42
cache: cache/cord-317403-1wrsuoy7.txt
txt: txt/cord-317403-1wrsuoy7.txt
summary:
  An unexpected outbreak of Middle East respiratory syndrome coronavirus infection in the Republic of Korea Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea South Korea): key: cord-317403-1wrsuoy7 authors: Yang, Jeong-Sun; Park, SungHan; Kim, You-Jin; Kang, Hae Ji; Kim, Hak; Han, Young Woo; Lee, Han Saem; Kim, Dae-Won; Kim, A-Reum; Heo, Deok Rim; Kim, Joo Ae; Kim, Su Jin; Nam, Jeong-Gu; Jung, Hee-Dong; Cheong, Hyang-Min; Kim, Kisoon; Lee, Joo-Shil; Kim, Sung Soon title: Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015 date: 2015-11-17 journal: Emerg Infect Dis DOI: 10.3201/eid2111.151016 sha: doc_id: 317403 cord_uid: 1wrsuoy7 In May 2015, Middle East respiratory syndrome coronavirus infection was laboratory confirmed in South Korea.


id: cord-306923-eujbxdqi
author: Ahmed, Anwar E.
date: 2018-04-25
extension: .txt
mime: text/plain
words: 2710
sentence: 104
flesch: 39
cache: cache/cord-306923-eujbxdqi.txt
txt: txt/cord-306923-eujbxdqi.txt
title:
  Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study

summary:
  The Poisson and negative binomial models were used to model the frequency of recovery delay in days and identify unadjusted and adjusted factors associated with longer recovery delay. key: cord-306923-eujbxdqi authors: Ahmed, Anwar E.; Al‐Jahdali, Hamdan; Alaqeel, Mody; Siddiq, Salma S.; Alsaab, Hanan A.; Sakr, Ezzeldin A.; Alyahya, Hamed A.; Alandonisi, Munzir M.; Subedar, Alaa T.; Ali, Yosra Z.; Al Otaibi, Hazza; Aloudah, Nouf M.; Baharoon, Salim; Al Johani, Sameera; Alghamdi, Mohammed G. title: Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study date: 2018-04-25 journal:


id: cord-031840-k9l91unc
author: Lu, Li
title: Forum: COVID-19 Dispatches
date: 2020-09-11
extension: .txt
mime: text/plain
words: 15690
sentence: 603
flesch: 50
cache: cache/cord-031840-k9l91unc.txt
txt: txt/cord-031840-k9l91unc.txt
summary:
  Viruses are viruses are viruses. With the similar control of cases less than 20,000, Japan and South Korea remain at the heart of this imagined safe zone in company with China even though the reality has seen even fewer confirmed cases in other parts of Asia as well as the recent resurgence of virus spreading in all these three countries.


id: cord-304054-sn7rswab
author: Khan, Gulfaraz
title: Chapter 8 The Middle East Respiratory Syndrome Coronavirus: An Emerging Virus of Global Threat
date: 2020-12-31
extension: .txt
mime: text/plain
words: 4276
sentence: 138
flesch: 40
cache: cache/cord-304054-sn7rswab.txt
txt: txt/cord-304054-sn7rswab.txt
summary:
  respiratory syndrome coronavirus Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Middle East respiratory syndrome coronavirus infection during pregnancy: a report of 5 cases from Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Emerging and reemerging diseases in the World Health Organization (WHO) Eastern Mediterranean Region-progress, challenges, and WHO initiatives MERS-CoV: understanding the latest human coronavirus threat Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study SARS and MERS: recent insights into emerging coronaviruses Transmission of MERS-coronavirus in household contacts Vaccines for the prevention against the threat of MERS-CoV Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Molecular evolution of human coronavirus genomes The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Outbreak of Middle East respiratory syndrome at Tertiary Care Hospital Transmission of Middle East Respiratory syndrome coronavirus infections in healthcare settings A novel coronavirus capable of lethal human infections: an emerging picture Middle East respiratory syndrome infection control and prevention guideline for healthcare facilities Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Transmission routes of respiratory viruses among humans Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo MERS coronavirus: diagnostics, epidemiology and transmission Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Jumping species-a mechanism for coronavirus persistence and survival Dipeptidyl peptidase 4 distribution in the human respiratory tract Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015 Asymptomatic MERS-CoV infection in humans possibly linked to infected dromedaries imported from Oman to United Arab Emirates Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia Middle East respiratory syndrome coronavirus disease is rare in children: an update from Saudi Arabia Occurrence of the Middle East respiratory syndrome coronavirus (MERS-CoV) across the gulf corporation council countries: four years update Further evidence for bats as the evolutionary source of Middle East


id: cord-305871-w1quh4fx
author: Hindawi, Salwa I.
date: 2017-12-14
extension: .txt
mime: text/plain
words: 4527
sentence: 155
flesch: 41
cache: cache/cord-305871-w1quh4fx.txt
txt: txt/cord-305871-w1quh4fx.txt
title:
  Inactivation of Middle East respiratory syndrome‐coronavirus in human plasma using amotosalen and ultraviolet A light

summary:
  Although the potential for MERS‐CoV transmission through blood transfusion is not clear, MERS‐CoV was recognized as a pathogen of concern for the safety of the blood supply especially after its detection in whole blood, serum, and plasma of infected individuals. Currently, there are more than 70 known pathogens that have been recognized by the AABB as pathogens of concern for blood transfusion; 25 however, blood donations are only screened for a small number of pathogens on a regular basis.


id: cord-306004-amv0los1
author: Widagdo, W.
title: Host Determinants of MERS-CoV Transmission and Pathogenesis
date: 2019-03-19
extension: .txt
mime: text/plain
words: 4537
sentence: 198
flesch: 42
cache: cache/cord-306004-amv0los1.txt
txt: txt/cord-306004-amv0los1.txt
summary:
  An epidemiological outbreak study Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: An in-vitro and ex-vivo study Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in United Arab Emirates Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Severe respiratory illness caused by a novel coronavirus Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Human betacoronavirus 2c EMC/2012-related viruses in bats MERS-related betacoronavirus in Vespertilio superans bats Group C betacoronavirus in bat guano fertilizer Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Close relative of human Middle East respiratory syndrome coronavirus in bat Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus Discovery of Novel Bat An outbreak investigation Human infection with MERS coronavirus after exposure to infected camels Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Antibodies against MERS coronavirus in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-alpha treatment TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection An overview of their replication and pathogenesis


id: cord-299565-shlhreve
author: Sweileh, Waleed M.
title: Global research trends of World Health Organization’s top eight emerging pathogens
date: 2017-02-08
extension: .txt
mime: text/plain
words: 6059
sentence: 248
flesch: 43
cache: cache/cord-299565-shlhreve.txt
txt: txt/cord-299565-shlhreve.txt
summary:
  Emerging infectious diseases in southeast Asia: regional challenges to control Risk of imported Ebola virus disease in China Emergence of Zaire Ebola virus disease in Guinea Ebola virus disease in West Africa-no early end to the outbreak Ebola viral disease outbreak-West Africa Recent outbreaks of rift valley Fever in East Africa and the middle East. Rift valley fever virus: unanswered questions Understanding Rift Valley fever: contributions of animal models to disease characterization and control Rift valley fever virus: a review of diagnosis and vaccination, and implications for emergence in Europe Emerging infections of CNS: avian influenza a virus, rift valley fever virus and human parechovirus Worldwide trends in infectious disease research revealed by a new bibliometric method Statistical methods for the prospective detection of infectious disease outbreaks: a review Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses An index to quantify an individual's scientific research output Bibliometrics of global Ebola Virus Disease research as seen through Science Citation Index Expanded during 1987-2015 A novel coronavirus associated with severe acute respiratory syndrome Bibliometric Analysis of Literature on Ebola (1995-2014)


id: cord-293938-40zyv1h8
author: Jonsdottir, Hulda R.
title: Coronaviruses and the human airway: a universal system for virus-host interaction studies
date: 2016-02-06
extension: .txt
mime: text/plain
words: 5536
sentence: 212
flesch: 34
cache: cache/cord-293938-40zyv1h8.txt
txt: txt/cord-293938-40zyv1h8.txt
summary:
  Tracheobronchial HAE cultures recapitulate the primary entry point of human respiratory viruses while the alveolar model allows for elucidation of mechanisms involved in viral infection and pathogenesis in the alveoli. This model is a universal platform to study human respiratory viruses [67]


id: cord-307995-8q7efrqk
author: Al-Tawfiq, Jaffar A.
title: Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
date: 2016-05-04
extension: .txt
mime: text/plain
words: 4444
sentence: 225
flesch: 51
cache: cache/cord-307995-8q7efrqk.txt
txt: txt/cord-307995-8q7efrqk.txt
summary:
  Mitigation through Detection, Research, and Response Saudi Arabia and the emergence of a novel coronavirus Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia An update on Middle East respiratory syndrome: 2 years later Health care worker contact with MERS patient, Saudi Arabia Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Middle East respiratory syndrome coronavirus case definition for reporting to WHO: interim case definition 14 Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Family cluster of Middle East respiratory syndrome coronavirus infections A family cluster of Middle East Respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study KSA MERS-CoV Investigation Team. Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia Imported cases of Middle East respiratory syndrome: an update The Hajj pilgrimage and surveillance for Middle East Respiratory syndrome coronavirus in pilgrims from African countries High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia Transmission of MERS-coronavirus in household contacts Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Heat inactivation of the Middle East respiratory syndrome coronavirus Infection prevention and control of epidemic-and pandemic prone acute respiratory infections in health care Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus Treating MERS-CoV during an outbreak Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel coronavirus replication by a combination of interferon-α2b and ribavirin Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Combination therapy with lopinavir/ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report


id: cord-318872-0e5zjaz1
author: Park, Ji-Eun
title: MERS transmission and risk factors: a systematic review
date: 2018-05-02
extension: .txt
mime: text/plain
words: 4161
sentence: 229
flesch: 54
cache: cache/cord-318872-0e5zjaz1.txt
txt: txt/cord-318872-0e5zjaz1.txt
summary:
  Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Synthesizing data and models for the spread of MERS-CoV, 2013: key role of index cases and hospital transmission Identified transmission dynamics of Middle East respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department A pandemic risk assessment of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach High reproduction number of Middle East respiratory syndrome coronavirus in nosocomial outbreaks: mathematical modelling in Saudi Arabia and South Korea Accessed 10 Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea Middle East respiratory syndrome and medical students: letter from China Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Estimating the risk of Middle East respiratory syndrome (MERS) death during the course of the outbreak in the Republic of Korea Multifacility outbreak of Middle East respiratory syndrome in Taif, Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia MERS-CoV outbreak in Jeddah-a link to health care facilities Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Taking stock of the first 133 MERS coronavirus cases globally-is the epidemic changing? Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Outbreak of Middle East respiratory syndrome at tertiary care hospital Clinical and epidemiologic characteristics of spreaders of Middle East respiratory syndrome coronavirus during the 2015 outbreak in Korea Nosocomial amplification of MERS-coronavirus in South Korea Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Impact of comorbidity on fatality rate of patients with Middle East respiratory syndrome The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Spread of mutant Middle East respiratory syndrome coronavirus with reduced affinity to human CD26 during the South Korean outbreak Variations in spike glycoprotein gene of MERS-CoV Association between Australian Hajj Pilgrims' awareness of MERS-CoV, and their compliance with preventive measures and exposure to camels Factors influencing preventive behavior against Middle East respiratory syndrome-coronavirus among nursing students in South Korea Middle East respiratory syndrome-related knowledge, preventive behaviours and risk perception among nursing students during outbreak Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea the role of super-spreaders in infectious disease Super-spreaders in infectious diseases Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis Authors' contributions JEP (corresponding author) designed the study, and conducted the data search and the analysis with JEP (1st author).


id: cord-309239-6lso1w0o
author: Adney, Danielle R.
title: Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding
date: 2016-08-19
extension: .txt
mime: text/plain
words: 2991
sentence: 121
flesch: 46
cache: cache/cord-309239-6lso1w0o.txt
txt: txt/cord-309239-6lso1w0o.txt
summary:
  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Rooting the phylogenetic tree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) origin and animal reservoir Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Serologic assessment of possibility for MERS-CoV infection in equids Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Replicative capacity of MERS coronavirus in livestock cell lines Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in Alpacas Infection with MERS-CoV causes lethal pneumonia in the common marmoset Experimental infection and response to rechallenge of Alpacas with Middle East respiratory syndrome coronavirus The goat kids were maintained at all times in a room with their mothers, who served as in-contact controls to test for virus transmission.


id: cord-320709-2pnqpljt
author: Munster, Vincent J.
title: Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)
date: 2016-02-22
extension: .txt
mime: text/plain
words: 3954
sentence: 139
flesch: 42
cache: cache/cord-320709-2pnqpljt.txt
txt: txt/cord-320709-2pnqpljt.txt
summary:
  In vitro, the MERS-CoV spike glycoprotein interacted with Jamaican fruit bat (Artibeus jamaicensis) dipeptidyl peptidase 4 (DPP4) receptor and MERS-CoV replicated efficiently in Jamaican fruit bat cells, suggesting there is no restriction at the receptor or cellular level for MERS-CoV. MERS-CoV replicated efficiently to high titers in both cell lines (Fig. 1B) , indicating that there is no restriction at the receptor or cellular level for MERS-CoV replication in Jamaican fruit bat cells.


id: cord-320921-eumuid3r
author: Widagdo, W.
title: Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits
date: 2019-04-24
extension: .txt
mime: text/plain
words: 4834
sentence: 198
flesch: 47
cache: cache/cord-320921-eumuid3r.txt
txt: txt/cord-320921-eumuid3r.txt
summary:
  Using immunohistochemistry, we analyzed the DPP4 expression in rabbit respiratory tract tissues. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Geographic distribution of MERS coronavirus among dromedary camels Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation Reported Direct and Indirect Contact with Dromedary Camels among Laboratory-Confirmed MERS-CoV Cases Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus Middle East respiratory syndrome coronavirus specific antibodies in naturally exposed Israeli llamas, alpacas and camels Infection, Replication, and Transmission of Middle East Respiratory Syndrome Coronavirus in Alpacas Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Airborne transmission of influenza A/H5N1 virus between ferrets New case-Qatari Supreme Council of Health Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Deletion Variants of Middle East Respiratory Syndrome Coronavirus from Humans Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels:


id: cord-328298-tm7gds8h
author: Gardner, Lauren M.
date: 2016-09-05
extension: .txt
mime: text/plain
words: 4998
sentence: 168
flesch: 48
cache: cache/cord-328298-tm7gds8h.txt
txt: txt/cord-328298-tm7gds8h.txt
title:
  Risk of global spread of Middle East respiratory syndrome coronavirus (MERS-CoV) via the air transport network

summary:
  For both scenarios all countries that have previously reported travel acquired cases were identified in the top 50, with the majority of countries reporting travel imported cases identified in the top 20. It should be noted, however, that several high-risk countries identified by the model have not had an imported case as of yet, whilst lower risk countries have.


id: cord-307405-qk1ruj5q
author: Hall, Aron J.
title: Health Care Worker Contact with MERS Patient, Saudi Arabia
date: 2014-12-17
extension: .txt
mime: text/plain
words: 1753
sentence: 55
flesch: 34
cache: cache/cord-307405-qk1ruj5q.txt
txt: txt/cord-307405-qk1ruj5q.txt
summary:
  Novel coronavirus (MERS-CoV) Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) into the United States First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities We are extremely grateful for the collaboration of the participating HCW in this investigation. key: cord-307405-qk1ruj5q authors: Hall, Aron J.; Tokars, Jerome I.; Badreddine, Samar A.; Saad, Ziad Bin; Furukawa, Elaine; Al Masri, Malak; Haynes, Lia M.; Gerber, Susan I.; Kuhar, David T.; Miao, Congrong; Trivedi, Suvang U.; Pallansch, Mark A.; Hajjeh, Rana; Memish, Ziad A. title: Health Care Worker Contact with MERS Patient, Saudi Arabia date: 2014-12-17 journal: Emerg Infect Dis DOI: 10.3201/eid2012.141211 sha: doc_id: 307405 cord_uid: qk1ruj5q To investigate potential transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) to health care workers in a hospital, we serologically tested hospital contacts of the index case-patient in Saudi Arabia, 4 months after his death.


id: cord-305317-08a1oin2
author: Maltezou, Helena C.
title: Middle East respiratory syndrome coronavirus: Implications for health care facilities
date: 2014-12-31
extension: .txt
mime: text/plain
words: 3647
sentence: 163
flesch: 46
cache: cache/cord-305317-08a1oin2.txt
txt: txt/cord-305317-08a1oin2.txt
summary:
  Ninth update Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Middle East respiratory syndrome coronavirus infections in health care workers First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital-associated outbreak of Middle East Respiratory Syndrome coronavirus: a serologic, epidemiologic, and clinical description A case of imported Middle East respiratory syndrome coronavirus infection and public health response Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Prediction of intrinsic disorder in MERS-CoV/ HCoV-EMC supports a high oral-fecal transmission Severe respiratory illness caused by a novel coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Contact investigation of a case of human novel coronavirus infection treated in a German hospital Current advancements and potential strategies in the development of MERS-CoV vaccines Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV) Preventing the spread of influenza A H1N1 2009 to health-care workers Illinois resident who had contact with Indiana MERS patient tests positive for MERS coronavirus Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus (MERS-CoV) e update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature updateeas of 9 Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia European Centre for Disease Prevention and Control.


id: cord-287761-73qgx58i
author: Aly, Mahmoud
date: 2017-10-13
extension: .txt
mime: text/plain
words: 3394
sentence: 133
flesch: 50
cache: cache/cord-287761-73qgx58i.txt
txt: txt/cord-287761-73qgx58i.txt
title:
  Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update

summary:
  Next, we sought out the detailed demographic distributions of reported cases among 14 governorates in Saudi Arabia. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an invitro and ex-vivo study Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Infection control and MERS-CoV in health-care workers MERS coronovirus has probably been present in bats for many years, research shows Link to MERS virus underscores bats' puzzling threat Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronavirus neutralizing antibodies in camels Animal models of Middle East respiratory syndrome coronavirus infection MERS-CoV


id: cord-295971-jtv1jj2z
author: Cho, Sun Young
date: 2016-07-09
extension: .txt
mime: text/plain
words: 4639
sentence: 175
flesch: 52
cache: cache/cord-295971-jtv1jj2z.txt
txt: txt/cord-295971-jtv1jj2z.txt
title:
  MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study

summary:
  The emergency room has its own radiology suite for emergency room patients only. Patients' demographic information, underlying disease, dates of emergency room visit, duration of stay with exact arrival and departure times, and location within the emergency room were collected.


id: cord-309734-m8miwtha
author: Vergara‐Alert, J.
title: Middle East respiratory syndrome coronavirus experimental transmission using a pig model
date: 2017-06-26
extension: .txt
mime: text/plain
words: 1793
sentence: 67
flesch: 51
cache: cache/cord-309734-m8miwtha.txt
txt: txt/cord-309734-m8miwtha.txt
summary:
  Transbound Emerg Dis DOI: 10.1111/tbed.12668 sha: doc_id: 309734 cord_uid: m8miwtha Dromedary camels are the main reservoir of Middle East respiratory syndrome coronavirus (MERS‐CoV), but other livestock species (i.e., alpacas, llamas, and pigs) are also susceptible to infection with MERS‐CoV. Animal‐to‐animal transmission in alpacas was reported, but evidence for transmission in other species has not been proved. Middle East respiratory syndrome coronavirus (MERS-CoV) was first detected in 2012 in Saudi Arabia, and it causes severe acute respiratory illness with fever, cough and shortness of breath (Zaki, van Boheemen, Bestebroer, Osterhaus, & Fouchier, 2012) .


id: cord-259703-9ef3u2mz
author: Alsolamy, Sami
title: Infection with Middle East respiratory syndrome coronavirus.
date: 2015
extension: .txt
mime: text/plain
words: 1275
sentence: 48
flesch: 29
cache: cache/cord-259703-9ef3u2mz.txt
txt: txt/cord-259703-9ef3u2mz.txt
summary:
  Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical management of severe acute respiratory infection when Middle East respiratory syndrome coronavirus (MERS-CoV) infection is suspected -Interim guidance Hypoxaemic rescue therapies in acute respiratory distress syndrome: Why, when, what and which one? Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: For commercial reuse, contact reprints@pulsus.com Middle East respiratory syndrome coronavirus (MERS-CoV) -Saudi Arabia: Disease outbreak news Evidence for camelto-human transmission of MERS coronavirus Family cluster of Middle East respiratory syndrome coronavirus infections Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study MERS-CoV outbreak in Jeddah -a link to health care facilities Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Emerging human Middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: A report of nosocomial transmission Middle East respiratory syndrome: Knowledge to date Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia An appropriate lower respiratory tract specimen is essential for diagnosis of Middle East respiratory syndrome (MERS)


id: cord-303272-1w8epdht
author: Reusken, Chantal BEM
date: 2013-08-09
extension: .txt
mime: text/plain
words: 4493
sentence: 172
flesch: 49
cache: cache/cord-303272-1w8epdht.txt
txt: txt/cord-303272-1w8epdht.txt
title:
  Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

summary:
  Cattle (n=80), sheep (n=40), goats (n=40), dromedary camels (n=155), and various other camelid species (n=34) were tested for specific serum IgG by protein microarray using the receptor-binding S1 subunits of spike proteins of MERS-CoV, severe acute respiratory syndrome coronavirus, and human coronavirus OC43. The receptor-binding domains, which contain the S1 subunit of spike proteins of MERS-CoV (residues 1-747), SARS-CoV (residues 1-676), and human coronavirus OC43 (residues 1-760) were expressed, purifi ed, and spotted on glass slides.


id: cord-018449-4vdqq961
author: Norrie, Philip
title: How Disease Affected the End of the Bronze Age
date: 2016-06-26
extension: .txt
mime: text/plain
words: 13138
sentence: 501
flesch: 61
cache: cache/cord-018449-4vdqq961.txt
txt: txt/cord-018449-4vdqq961.txt
summary:
  Focusing on Ancient Near East, the Near East had the earliest Bronze Age because Metallurgy developed fi rst in Anatolia, modern Turkey. The next stage in human cultural development was the Iron Age; this is the third and fi nal stage in the usual three-stage sequence of Stone Age, Bronze Age and Iron Age or the fourth in the more detailed fi ve-stage sequence of Stone Age, Copper Age, Bronze Age, Iron Age and Steel Age.


id: cord-313054-w90eitw9
author: Mobaraki, Kazhal
date: 2019-04-27
extension: .txt
mime: text/plain
words: 2190
sentence: 97
flesch: 51
cache: cache/cord-313054-w90eitw9.txt
txt: txt/cord-313054-w90eitw9.txt
title:
  Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1.2017 to 17.1.2018: a cross-sectional study

summary:
  The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea Middle East respiratory syndrome coronavirus Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Middle East respiratory syndrome coronavirus: review of the current situation in the world Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Isolation of MERS coronavirus from a dromedary camel Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE World Organization Health Middle East respiratory syndrome Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Hadj ritual and risk of a pandemic Transmission scenarios for Middle East respiratory syndrome coronavirus (MERS-CoV) and how to tell them apart Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Middle East respiratory syndrome novel corona (MERS-CoV) infection. The authors take this opportunity to thank all the WHO personnel as well as reporting countries with confirmed MERS cases for data collection and sending the data to WHO.


id: cord-323428-jd91k19z
author: Ababneh, Mustafa
date: 2019-10-11
extension: .txt
mime: text/plain
words: 5739
sentence: 224
flesch: 45
cache: cache/cord-323428-jd91k19z.txt
txt: txt/cord-323428-jd91k19z.txt
title:
  Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice

summary:
  Emergence of a novel human coronavirus Middle East respiratory syndrome coronavirus MERS-CoV: Current knowledge gaps Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans MERS-CoV--are we on the verge of a pandemic? Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation Antibodies against MERS coronavirus in dromedary camels Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus Type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant modified vaccinia virus ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th 1 and Th 2 responses against Middle East respiratory syndrome coronavirus Distribution and absence of generalized lesions in mice following single-dose intramuscular inoculation of the vaccine candidate MVA-MERS-S Immunogenicity of different forms of Middle East respiratory syndrome s glycoprotein ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC The receptor-binding domain of MERS-CoV: The dawn of vaccine and treatment development Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats Available at www.veterinaryworld.org Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus The Gene Delivery Company): Recombinant Adenovirus Construction Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Endogenous biotin expression in renal and testicular tumors and literature review Retrieved endogenous biotin: S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime.


id: cord-299519-hfgmmuy6
author: Alenazi, Thamer H.
title: Severe Middle East Respiratory Syndrome (MERS) Pneumonia
date: 2019-10-26
extension: .txt
mime: text/plain
words: 5553
sentence: 208
flesch: 41
cache: cache/cord-299519-hfgmmuy6.txt
txt: txt/cord-299519-hfgmmuy6.txt
summary:
  Post-mortem autopsies were rarely performed on MERS patients due to cultural reasons in the Arabian Peninsula. A study that compared 330 critically ill MERS-CoV infected patients with 220 critically ill patients with non-MERS severe acute respiratory infection (SARI) found that MERS patients were younger than non-MERS SARI patients (median [Q1, Q3] 58


id: cord-297954-87w2itin
author: Memish, Ziad A.
date: 2015-07-15
extension: .txt
mime: text/plain
words: 1864
sentence: 88
flesch: 57
cache: cache/cord-297954-87w2itin.txt
txt: txt/cord-297954-87w2itin.txt
title:
  Middle East respiratory syndrome coronavirus (MERS-CoV): A cluster analysis with implications for global management of suspected cases

summary:
  Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers An update on Middle East respiratory syndrome: 2 years later Middle East respiratory syndrome coronavirus infection control: the missing piece? Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution Travel implications of emerging coronaviruses: SARS and MERS-CoV Middle east respiratory syndrome coronavirus (MERS-CoV) in healthcare setting Family cluster of Middle East respiratory syndrome coronavirus infections epidemiological findings from a retrospective investigation Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Hospital outbreak of Middle East respiratory syndrome coronavirus An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia MERS-CoV outbreak in Jeddahea link to health care facilities Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Middle East respiratory syndrome coronavirus (MERS-CoV)-17th update Middle East respiratory syndrome coronavirus (MERS-CoV): summary and risk assessment of current situation in the Republic of Korea and China Etiology of severe community-acquired pneumonia during Hajjdpart of the MERS-CoV surveillance program Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms The Hajj pilgrimage and surveillance for Middle East respiratory syndrome coronavirus in pilgrims from African countries Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Imported cases of Middle East respiratory syndrome: an update We are grateful to the staff of the Ministry of Health in Al-Madinah area and the staff of the regional laboratory, Kingdom of Saudi Arabia. Travel associated MERS cases were reported from: Turkey, Austria, United Kingdom, Germany, France, Greece, the Netherlands, Tunisia, Algeria, Malaysia, Philippines, China, and the United States of America [17] .


id: cord-343302-g9vcchrh
author: Agrawal, Anurodh Shankar
date: 2016-08-19
extension: .txt
mime: text/plain
words: 4820
sentence: 148
flesch: 39
cache: cache/cord-343302-g9vcchrh.txt
txt: txt/cord-343302-g9vcchrh.txt
title:
  Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

summary:
  The effect of m336 antibody treatment on the pulmonary pathology associated with MERS-CoV infection was evaluated by using formalin-fixed, paraffin embedded, and hematoxylin/eosin (H&E)-stained lung specimens harvested at day 2 p.i. We report in this study for the first time that treatment of Tg mice with a single-dose of m336 antibody prior to or after challenging with 1,000 LD 50 of MERS-CoV protected mice from the lethality in a dose-dependent manner, thereby representing the first antibody tested for its protective efficacy against lethal MERS-CoV infection.


id: cord-297853-peqkcix2
author: Khan, Raymond M.
date: 2016-11-01
extension: .txt
mime: text/plain
words: 1473
sentence: 57
flesch: 43
cache: cache/cord-297853-peqkcix2.txt
txt: txt/cord-297853-peqkcix2.txt
title:
  Middle East respiratory syndrome coronavirus on inanimate surfaces: A risk for health care transmission

summary:
  CDC's early response to a novel viral disease, middle east respiratory syndrome coronavirus (MERS-CoV) Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Comparison of surface sampling methods for virus recovery from fomites Hospital outbreak of Middle East respiratory syndrome coronavirus Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Rapid and effective virucidal activity of povidoneiodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus ankara (MVA) Heat inactivation of the Middle East respiratory syndrome coronavirus 9 Prolonged viral shedding 8, 9 and survival on surfaces for 48 hours 3 make it difficult to ignore contaminated environmental surfaces as a potential etiology of hospital outbreaks.


id: cord-330343-p7a8chn4
author: Kelly-Cirino, Cassandra
title: An updated roadmap for MERS-CoV research and product development: focus on diagnostics
date: 2019-02-01
extension: .txt
mime: text/plain
words: 5814
sentence: 170
flesch: 26
cache: cache/cord-330343-p7a8chn4.txt
txt: txt/cord-330343-p7a8chn4.txt
summary:
  WHO MERS-COV R&D Blueprint Plan of Action R&D Blueprint for action to prevent epidemics Progress on the global response, remaining challenges and the way forward Evidence for camel-tohuman transmission of MERS coronavirus Human-dromedary camel interactions and the risk of acquiring zoonotic middle east respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt MERS coronaviruses in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Absence of Middle East Respiratory Syndrome Coronavirus in Camelids Antibodies against MERS coronavirus in dromedary camels Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Lack of middle East respiratory syndrome coronavirus transmission from infected camels MERS coronavirus in dromedary camel herd, Saudi Arabia Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Serologic Evidence for MERS-CoV Infection in Dromedary Camels Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation MERS-CoV situation update, Map 1. MERS-CoV livestock field surveys by country Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates MERS CoV: OIE -World organisation for animal health Occupational exposure to dromedaries and risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study Middle East Respiratory Syndrome (MERS) | Symptoms & Complications | CDC Middle East respiratory syndrome coronavirus disease in children Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia Transmission of MERScoronavirus in household contacts Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description The Role of Super-Spreaders in Infectious Disease Super-spreading events of MERS-CoV infection MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus WHO | Infection prevention and control (IPC) guidance summary. WHO MERS-COV Lab Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Performance and clinical validation of the RealStar MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Development of dual taqman based one-step rrt-pcr assay panel for rapid and accurate diagnostic test of MERS-CoV: a novel human coronavirus, ahead of hajj pilgrimage Development and validation of a rapid immunochromatographic assay for detection of Middle East respiratory syndrome coronavirus antigen in dromedary camels An isothermal, label-free, and rapid one-step RNA amplification/detection assay for diagnosis of respiratory viral infections Comparison of ePlex respiratory pathogen panel with laboratory-developed real-time pcr assays for detection of respiratory pathogens Clinical validation of 3 commercial real-time reverse transcriptase polymerase chain reaction assays for the detection of Middle East respiratory syndrome coronavirus from upper respiratory tract specimens A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus A highly specific rapid antigen detection assay for on-site diagnosis of MERS Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Lateral flow assays Development of monoclonal antibody and diagnostic test for middle east respiratory syndrome coronavirus using cell-free synthesized nucleocapsid antigen Middle East respiratory syndrome (MERS) coronavirus and dromedaries Identification of Mycoplasma suis antigens and development of a multiplex microbead immunoassay Serosurveillance of viral pathogens circulating in West Africa Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses A multiplex liquid-chip assay based on Luminex xMAP technology for simultaneous detection of six common respiratory viruses Surveillance and testing for middle east respiratory syndrome coronavirus Using Healthmap to analyse Middle East Respiratory Syndrome (MERS) data Progress in promoting data sharing in public health emergencies WHO | Influenza surveillance outputs Data sharing: make outbreak research open access The weapon potential of a microbe Biological agents: weapons of warfare and bioterrorism Explanation of the Nagoya Protocol on Access and Benefit Sharing and its implication for microbiology Global scientific research commons under the Nagoya Protocol:


id: cord-332952-d5l60cgc
title: MERS: Progress on the global response, remaining challenges and the way forward
date: 2018-09-17
extension: .txt
mime: text/plain
words: 5562
sentence: 113
flesch: 13
cache: cache/cord-332952-d5l60cgc.txt
txt: txt/cord-332952-d5l60cgc.txt
summary:
  The prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) antibodies in dromedary camels in Israel Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia MERS outbreak in Korea: hospital-to-hospital transmission Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS outbreak units Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Influenza not MERS CoV among returning Hajj and Umrah pilgrims with respiratory illness Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus No MERS-CoV but positive influenza viruses in returning Hajj pilgrims, China MERS coronavirus in dromedary camel herd, Saudi Arabia Lack of Middle East respiratory syndrome coronavirus transmission from infected camels Acute respiratory infections in travelers returning from MERS-CoV-affected areas Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program Prevalence of MERS-CoV Nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications Antibodies against MERS coronavirus in dromedary camels Absence of Middle East respiratory syndrome coronavirus in Camelids Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir Infectivity of an asymptomatic patient with Middle East respiratory syndrome coronavirus infection Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study MERS coronavirus neutralizing antibodies in camels Event based surveillance of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Bangladesh among pilgrims and travelers from the Middle East: an update for the period High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels MERS-CoV outbreak in Jeddah -a link to health care facilities Group on MERS-cov Infection in Animals Infection with Coronavirus in Camels Middle East Respiratory Syndrome Coronavirus (MERS-cov) Case Definition for Reporting to OIE Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Isolation of MERS coronavirus from a dromedary camel Cross-sectional survey and surveillance for influenza viruses and MERS-CoV among Egyptian pilgrims returning from Hajj during 2012-2015 Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Specific serology for emerging human coronaviruses by protein microarray Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Serologic evidence for MERS-CoV infection in dromedary camels Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Development and validation of a rapid immunochromatographic assay for detection of Middle East respiratory syndrome coronavirus antigen in dromedary camels State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Influenza Aerosols in UK Hospitals during the H1N1 (2009) Pandemic -the Risk of Aerosol Generation during Medical Procedures Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions High prevalence of Middle East respiratory coronavirus in young dromedary camels in Jordan. Surveillance and testing for Middle East respiratory syndrome coronavirus, Saudi Arabia Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Response to emergence of Middle East respiratory syndrome coronavirus Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Acute respiratory infections among returning Hajj pilgrims-Jordan Infectious MERS-CoV isolated from a mildly Ill patient, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice Cross-sectional surveillance of Middle East R MERS-CoV) in dromedary camels and other mammals in Egypt Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt Association between Australian Hajj Pilgrims' awareness of MERS-CoV, and their compliance with preventive measures and exposure to camels Unusual presentation of Middle East respiratory syndrome coronavirus leading to a large outbreak in Riyadh during 2017 High prevalence of common respiratory viruses and no evidence of Middle East Respiratory Syndrome Coronavirus in Hajj pilgrims returning to Ghana Critically Ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study Middle East respiratory syndrome Corticosteroid therapy for critically Ill patients with Middle East respiratory syndrome Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Middle East respiratory syndrome coronavirus antibodies in dromedary camels Hospital outbreak of Middle East respiratory syndrome coronavirus Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travellers and pilgrims from the Middle East: a prospective descriptive study for the period 2013-2015 Evidence for camel-to-human transmission of MERS coronavirus Description of a hospital outbreak of Middle East respiratory syndrome in a large tertiary care hospital in Saudi Arabia Viral respiratory infections among Hajj pilgrims in 2013 Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Middle East respiratory syndrome coronavirus quasispecies that include homologues of human Isolates revealed through wholegenome analysis and virus cultured from dromedary camels in Saudi Arabia Geographic distribution of MERS coronavirus among dromedary camels MERS-CoV infection of alpaca in a region where MERS-CoV is endemic MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Antibodies against MERS coronavirus in dromedary camels Experimental infection and response to rechallenge of alpacas with Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus specific antibodies in naturally exposed Israeli llamas, alpacas and camels Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Transmission of MERS-coronavirus in household contacts An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia Toward developing a preventive MERS-CoV vaccine-report from a workshop organized by the Saudi Arabia Ministry of health and the international vaccine Institute Dromedary camels in northern Mali have high seropositivity to MERS-CoV FAO, 2014.


id: cord-017741-5apdhf2e
author: Hussels, Stephanie
title: South and East Asian Insurance Market Growth and Development
date: 2007
extension: .txt
mime: text/plain
words: 9333
sentence: 391
flesch: 41
cache: cache/cord-017741-5apdhf2e.txt
txt: txt/cord-017741-5apdhf2e.txt
summary:
  In particular, recent empirical research on insurance markets by Beck and Webb (2003) , Browne, et al. (2000) , Esho, et al. (2004) , and Ward and Zurbruegg (2002) have shown that the level of insurance demand within an economy can be influenced by a number of particular variables, including economic, legal, political, and social factors. Both Singapore and Hong Kong have well-established insurance markets and, due to the deregulation of financial markets, insurance markets in other countries within this region have also begun to grow over the past five to ten years.


id: cord-318181-xxc7vdnt
author: Ahmed, Anwar E.
date: 2018-03-14
extension: .txt
mime: text/plain
words: 4390
sentence: 150
flesch: 43
cache: cache/cord-318181-xxc7vdnt.txt
txt: txt/cord-318181-xxc7vdnt.txt
title:
  Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

summary:
  Accuracy and cost comparison in medical testing using sequential testing strategies Reducing cost in sequential testing: a limit of indifference approach Believe the extreme (BE) strategy at the optimal point: what strategy will it become Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study The predictors of 3-and 30-day mortality in 660 MERS-CoV patients MERS-CoV diagnosis: an update The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective study Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Laboratory testing for Middle East respiratory syndrome coronavirus (MERS-CoV) Case definition and surveillance guidance -updated Critically ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Evidence for camel-to-human transmission of MERS coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Clinical presentation and outcomes of Middle East Respiratory Syndrome in the Republic of Korea Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Combining biomarkers to detect disease with application to prostate cancer Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate MERS-CoV outbreak in Jeddah-a link to health care facilities Combining diagnostic test results to increase accuracy MERS-CoV geography and ecology in the Middle East: analyses of reported camel exposures and a preliminary risk map Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia On the principles of believe the positive and believe the negative for diagnosis using two continuous tests Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Emerging molecular markers of cancer Linear combinations of multiple diagnostic markers Comparative evaluation of three homogenization methods for isolating Middle East key: cord-318181-xxc7vdnt authors: Ahmed, Anwar E.; Al-Jahdali, Hamdan; Alshukairi, Abeer N.; Alaqeel, Mody; Siddiq, Salma S.; Alsaab, Hanan; Sakr, Ezzeldin A.; Alyahya, Hamed A.; Alandonisi, Munzir M.; Subedar, Alaa T.; Aloudah, Nouf M.; Baharoon, Salim; Alsalamah, Majid A.; Al Johani, Sameera; Alghamdi, Mohammed G. title: Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia date: 2018-03-14 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2018.03.005 sha: doc_id: 318181 cord_uid: xxc7vdnt BACKGROUND: The rapid and accurate identification of individuals who are at high risk of Middle East respiratory syndrome coronavirus (MERS-CoV) infection remains a major challenge for the medical and scientific communities.


id: cord-319877-izn315hb
author: de Wit, Emmie
title: SARS and MERS: recent insights into emerging coronaviruses
date: 2016-06-27
extension: .txt
mime: text/plain
words: 9406
sentence: 277
flesch: 31
cache: cache/cord-319877-izn315hb.txt
txt: txt/cord-319877-izn315hb.txt
summary:
  Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage A two-pronged strategy to suppress host protein synthesis by SARS coronavirus nsp1 protein Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain Middle East respiratory syndrome coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of cytoplasmic origin Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists MAVS-mediated apoptosis and its inhibition by viral proteins Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses Mechanisms of action of ribavirin against distinct viruses Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical analysis of the first patient with imported Middle East respiratory syndrome in China Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Identification of severe acute respiratory syndrome in Canada Development of a standard treatment protocol for severe acute respiratory syndrome A cluster of cases of severe acute respiratory syndrome in Hong Kong Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques The first application of a potential treatment option for MERS through the repurposing of IFNα2b and ribavirin in a non-human primate model Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Combination therapy with lopinavir/ ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report Clinical implications of five cases of Middle East respiratory syndrome coronavirus infection in South Korea Outbreak From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design Thiopurine analogs and mycophenolic acid synergistically inhibit the papainlike protease of Middle East respiratory syndrome coronavirus Ligand-induced dimerization of Middle East respiratory syndrome (MERS) coronavirus nsp5 protease (3CL pro ): implications for nsp5 regulation and the development of antivirals Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture International Severe Acute Respiratory & Emerging Infection Consortium. WHO Nidovirus transcription: how to make sense…? Coronaviruses post-SARS: update on replication and pathogenesis Coronaviruses: an overview of their replication and pathogenesis SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage Infidelity of SARS-CoV nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS Middle East respiratory syndrome coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Evidence for camel-to-human transmission of MERS coronavirus MERS coronavirus in dromedary camel herd, Saudi Arabia Isolation of MERS coronavirus from a dromedary camel Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study An analysis of the predominant role for nosocomial transmission in the epidemiology of both SARS and MERS Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study A description of the clinical representation of SARS-CoV respiratory disease in patients from Hong Kong Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Evidence that infectious MERS-CoV can be detected on common hospital surfaces during an outbreak, which highlights the potential for nosocomial transmission and stresses the need for infection control The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Middle East respiratory syndrome coronavirus superspreading event involving 81 persons the role of super-spreaders in infectious disease Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Biomarkers in acute respiratory distress syndrome The mercurial nature of neutrophils: still an enigma in ARDS? SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Genome wide identification of SARS-CoV susceptibility loci using the Collaborative Cross Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV Rapid generation of a mouse model for Middle East respiratory syndrome A study in which the DPP4-based host restriction is overcome in mice by expression of the human variant of DPP4, leading to the development of several transgenic mouse models MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex


id: cord-287156-3plpi6i9
author: Lassandro, Giuseppe
title: Children in Coronaviruses’ Wonderland: What Clinicians Need to Know
date: 2020-07-01
extension: .txt
mime: text/plain
words: 8034
sentence: 366
flesch: 36
cache: cache/cord-287156-3plpi6i9.txt
txt: txt/cord-287156-3plpi6i9.txt
summary:
  Multisystem Inflammatory Syndrome in Children in COVID-19-associated immune thrombocytopenia Immune Thrombocytopenia (ITP) in a SARS-CoV-2 Positive Pediatric Patient Covid-19 and Children with Immune Thrombocytopenia: Emerging Issues Evans syndrome in a patient with COVID-19 COVID-19 infection associated with autoimmune hemolytic anemia Chest computed tomography in children with COVID-19 respiratory infection Clinical and CT imaging features of the COVID-19 pneumonia: Influenza Other Respir Viruses Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou Human Coronavirus Infections in Israel: Epidemiology, Clinical Symptoms and Summer Seasonality of HCoV-HKU1.


id: cord-309621-6jj19xpr
author: Yu, Pin
date: 2017-02-24
extension: .txt
mime: text/plain
words: 4647
sentence: 174
flesch: 36
cache: cache/cord-309621-6jj19xpr.txt
txt: txt/cord-309621-6jj19xpr.txt
title:
  Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus

summary:
  Here, we comprehensively describe the histopathological features of the disease and the distribution of the MERS-CoV antigen and DDP4 in rhesus macaque and common marmoset models. key: cord-309621-6jj19xpr authors: Yu, Pin; Xu, Yanfeng; Deng, Wei; Bao, Linlin; Huang, Lan; Xu, Yuhuan; Yao, Yanfeng; Qin, Chuan title: Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus date: 2017-02-24 journal: PLoS One DOI: 10.1371/journal.pone.0172093 sha: doc_id: 309621 cord_uid: 6jj19xpr Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged.


id: cord-317688-mr851682
author: Oh, Myoung-don
title: Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea
date: 2018-02-27
extension: .txt
mime: text/plain
words: 5576
sentence: 230
flesch: 45
cache: cache/cord-317688-mr851682.txt
txt: txt/cord-317688-mr851682.txt
summary:
  respiratory syndrome coronavirus KOR/KNIH/002_05_2015, isolated in South Korea Complete genome sequence of Middle East Respiratory syndrome coronavirus (MERS-CoV) from the first imported MERS-CoV case in China Isolation of Middle East respiratory syndrome coronavirus from a patient of the 2015 Korean outbreak Microevolution of outbreak-associated Middle East respiratory syndrome coronavirus, South Korea Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombination Variations in spike glycoprotein gene of MERS-CoV Spread of mutant Middle East respiratory syndrome coronavirus with reduced affinity to human CD26 during the South Korean outbreak Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms Viral load kinetics of MERS coronavirus infection Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Kinetics of serologic responses to MERS coronavirus infection in humans Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity MERS-CoV antibody responses 1 year after symptom onset, South Korea Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Clinical implications of 5 cases of Middle East respiratory syndrome coronavirus infection in a South Korean outbreak Clinical progression and cytokine profiles of Middle East respiratory syndrome coronavirus infection Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Renal complications and their prognosis in Korean patients with Middle East respiratory syndrome-coronavirus from the central MERS-CoV designated hospital Neurological complications during treatment of Middle East respiratory syndrome Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Differential cell count and CRP level in blood as predictors for Middle East respiratory syndrome coronavirus infection in acute febrile patients during nosocomial outbreak Guidelines for the laboratory diagnosis of Middle East respiratory syndrome coronavirus in Korea Korean Society for Laboratory Medicine practice guidelines for the molecular diagnosis of Middle East respiratory syndrome during an outbreak in Korea in 2015 Importance of specimen type and quality in diagnosing Middle East respiratory syndrome An appropriate lower respiratory tract specimen is essential for diagnosis of Middle East respiratory syndrome (MERS) Atypical presentations of MERS-CoV infection in immunocompromised hosts Antiviral treatment guidelines for Middle East respiratory syndrome Predictors of mortality in Middle East respiratory syndrome (MERS) Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Real-time characterization of risks of death associated with the Middle East respiratory syndrome (MERS) in the Republic of Korea Viral RNA in blood as indicator of severe outcome in Middle East respiratory syndrome coronavirus infection Association between severity of MERS-CoV infection and incubation period MERS-CoV infection in a pregnant woman in Korea Successful treatment of suspected organizing pneumonia in a patient with Middle East respiratory syndrome coronavirus infection: a case report Mental health status of people isolated due to Middle East respiratory syndrome Possible transfusionrelated acute lung injury following convalescent plasma transfusion in a patient with Middle East respiratory syndrome Middle East respiratory syndrome infection control and prevention guideline for healthcare facilities Middle East respiratory syndrome coronavirus transmission in dialysis unit and infection control interventions in Korea Middle East respiratory syndrome clinical practice guideline for hemodialysis facilities Stability of Middle East respiratory syndrome coronavirus (MERS-246 www CoV) under different environmental conditions Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Environmental contamination and viral shedding in MERS patients Viral shedding and environmental cleaning in Middle East respiratory syndrome coronavirus infection Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS isolation wards Transmissibility of Middle East respiratory syndrome by the airborne route Nosocomial amplification of MERScoronavirus in South Korea Healthcare worker infected with Middle East Respiratory Syndrome during cardiopulmonary resuscitation in Korea Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity Seroprevalence of Middle East respiratory syndrome coronavirus among healthcare personnel caring for patients with middle east respiratory syndrome in South Korea Serologic evaluation of MERS screening strategy for healthcare personnel during a hospital-associated outbreak Middle East respiratory syndrome coronavirus transmission in dialysis unit and infection control interventions in Korea Management of asymptomatic persons who are RT-PCR positive for Middle East respiratory syndrome coronavirus (MERS-CoV): Interim guidance [Internet].


id: cord-314651-e4uaw5fy
author: Zhao, Guangyu
date: 2015-12-23
extension: .txt
mime: text/plain
words: 4174
sentence: 144
flesch: 38
cache: cache/cord-314651-e4uaw5fy.txt
txt: txt/cord-314651-e4uaw5fy.txt
title:
  Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

summary:
  Systemic inflammation is believed to be a primary reason for the severe outcome in MERS--CoV infections [14, 24] . To evaluate MERS-CoV infection in the hDPP4 transgenic mice, distribution of the viral antigen NP protein was assessed in mouse tissues by immunohistochemical staining.


id: cord-315576-bgcqkz0p
author: Yamamoto, Naoki
date: 2020-08-05
extension: .txt
mime: text/plain
words: 6125
sentence: 230
flesch: 47
cache: cache/cord-315576-bgcqkz0p.txt
txt: txt/cord-315576-bgcqkz0p.txt
title:
  Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: Four hypotheses for possible explanation

summary:
  Although the weight of this habit in preventing virus infection is not clear at this moment, this difference indicates that Asians very clearly distinguish between outdoor and indoor in daily life. However, 21 our hypothesis suffers from the lack of analogous data available in other viral infections.


id: cord-323125-qtlevnbt
author: Al Hosani, Farida Ismail
date: 2019-02-01
extension: .txt
mime: text/plain
words: 3710
sentence: 153
flesch: 42
cache: cache/cord-323125-qtlevnbt.txt
txt: txt/cord-323125-qtlevnbt.txt
title:
  Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates

summary:
  Data collected included demographics; residence/household description; exposure history to other MERS-CoV cases, healthcare settings, and animals; travel history; and medical history, including any long-term effects reported by case patients. Females comprised a higher proportion of case patients compared with household contacts (70.6% vs 53.2%), and case patients were older compared with household contacts (median, 42 years vs 31 years).


id: cord-327867-1wkbjtji
author: Da'ar, Omar B.
date: 2018-06-11
extension: .txt
mime: text/plain
words: 3188
sentence: 138
flesch: 45
cache: cache/cord-327867-1wkbjtji.txt
txt: txt/cord-327867-1wkbjtji.txt
title:
  Underlying trend, seasonality, prediction, forecasting and the contribution of risk factors: an analysis of globally reported cases of Middle East Respiratory Syndrome Coronavirus

summary:
  MERS situation update Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study Building predictive models for MERS-CoV infections using data mining techniques Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Risk factors for severity and mortality in patients with MERS-CoV: analysis of publicly available data from Saudi Arabia Risks of death and severe disease in patients with Middle East respiratory syndrome coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Hospital outbreak of Middle East respiratory syndrome coronavirus Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Evidence of person-to-person transmission within a family cluster of novel coronavirus infections The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections MERS-CoV outbreak in Jeddah-a link to health care facilities Human-Dromedary camel interactions and the risk of acquiring zoonotic Middle East respiratory syndrome coronavirus infection Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Acknowledgements. The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Development of a risk-prediction model for Middle East respiratory syndrome coronavirus infection in dialysis patients Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Severe acute respiratory syndrome vs. the Middle East respiratory syndrome Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus (MERS-CoV).


id: cord-345081-15s2i6f0
author: Al-Sehaibany, Fares S.
title: Middle East respiratory syndrome in children: Dental considerations
date: 2017-04-17
extension: .txt
mime: text/plain
words: 2655
sentence: 115
flesch: 36
cache: cache/cord-345081-15s2i6f0.txt
txt: txt/cord-345081-15s2i6f0.txt
summary:
  Update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update-as of Middle East respiratory syndrome (MERS): a new zoonotic viral pneumonia State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans MERS-CoV outbreak in Jeddah--a link to health care facilities A scenario-based evaluation of the Middle East respiratory syndrome coronavirus and the Hajj Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus infections in health care workers Middle East respiratory syndrome Middle East respiratory syndrome coronavirus in children Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises Aerosols and splatter in dentistry: a brief review of the literature and infection control implications Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study A family cluster of Middle East respiratory syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Effects of Coronavirus infections in children Cultivation of bacteria and fungi Occupational Health problems in modern dentistry: a review Blood contamination of the aerosols produced by in vivo use of ultrasonic scalers Aerosol and splatter contamination from the operative site during ultrasonic scaling Characteristics of blood-containing aerosols generated by common powered dental instruments Measurement of airborne bacteria and endotoxin generated during dental cleaning Efficacy of three face masks in preventing inhalation of airborne contaminants in dental practice Infected health care workers and patient safety: a double standard Risk assessment of dental unit waterline contamination A survey of methods used to detect nosocomial legionellosis among participants in the National Nosocomial Infections Surveillance System Legionella contamination of dental-unit water Emerging and changing viral diseases in the new millennium Middle East respiratory syndrome coronavirus MERS-CoV: current knowledge gaps In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus (MERS-CoV).


id: cord-319006-6f2sl0bp
author: Plipat, Tanarak
date: 2017-08-17
extension: .txt
mime: text/plain
words: 3964
sentence: 167
flesch: 49
cache: cache/cord-319006-6f2sl0bp.txt
txt: txt/cord-319006-6f2sl0bp.txt
title:
  Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand, June 2015

summary:
  [Guidelines for diagnosing and treating MERS patients, as well as protocols to prevent an outbreak in the hospital Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus: update for clinicians International Health Regulations None declared. Some passengers voluntarily reported to a hospital or health authority in response to the MOPH's announcement of first imported MERS case in Thailand.


id: cord-332237-8oykgp0h
author: Omrani, Ali S
date: 2014-09-29
extension: .txt
mime: text/plain
words: 3323
sentence: 130
flesch: 44
cache: cache/cord-332237-8oykgp0h.txt
txt: txt/cord-332237-8oykgp0h.txt
title:
  Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study

summary:
  Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-11th update Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Hospital outbreak of Middle East respiratory syndrome coronavirus Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical management of severe acute respiratory infections when novel coronavirus is suspected: what to do and what not to do International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) key: cord-332237-8oykgp0h authors: Omrani, Ali S; Saad, Mustafa M; Baig, Kamran; Bahloul, Abdelkarim; Abdul-Matin, Mohammed; Alaidaroos, Amal Y; Almakhlafi, Ghaleb A; Albarrak, Mohammed M; Memish, Ziad A; Albarrak, Ali M title: Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study date: 2014-09-29 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(14)70920-x sha: doc_id: 332237 cord_uid: 8oykgp0h BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) infection is associated with high mortality and has no approved antiviral therapy.


id: cord-349262-gnqbyc6t
author: Hemida, Maged Gomaa
date: 2020-10-14
extension: .txt
mime: text/plain
words: 3174
sentence: 145
flesch: 58
cache: cache/cord-349262-gnqbyc6t.txt
txt: txt/cord-349262-gnqbyc6t.txt
title:
  The Middle East respiratory syndrome coronavirus in the breath of some infected dromedary camels (Camelus dromedarius)

summary:
  Middle East respiratory syndrome coronavirus (MERS-CoV) neutralising antibodies in a high-risk human population Comparative serological study for the prevalence of anti-MERS coronavirus antibodies in high-and low-risk groups in Qatar Middle East respiratory syndrome coronavirus during pregnancy Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Longitudinal study of Middle East respiratory syndrome coronavirus infection in dromedary camel herds in Saudi Arabia MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Africa and Middle East Genetic evidence of Middle East respiratory syndrome coronavirus (MERS-Cov) and widespread seroprevalence among camels in Kenya Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate MERS-CoV at the animal-human interface: inputs on exposure pathways from an expert-opinion elicitation Middle East respiratory syndrome coronavirus and the one health concept Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) The viral RNAs were extracted from paired swabs and breath samples collected from dromedary camels using the Qiagen viral RNA (RNeasy Mini Kit, Qiagen, Hilden, Germany) extraction kit, according to the manufacturer's protocol.


id: cord-354302-l2kywzro
author: Adney, Danielle R.
title: Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
date: 2014-12-17
extension: .txt
mime: text/plain
words: 3291
sentence: 119
flesch: 43
cache: cache/cord-354302-l2kywzro.txt
txt: txt/cord-354302-l2kywzro.txt
summary:
  Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Dynamics of passive immunity to West Nile virus in domestic chickens (Gallus gallus domesticus) Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through wholegenome analysis and virus cultured from dromedary camels in Saudi Arabia Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV).


id: cord-322760-tsxniu3j
author: Sha, Jianping
date: 2016-09-23
extension: .txt
mime: text/plain
words: 4632
sentence: 183
flesch: 53
cache: cache/cord-322760-tsxniu3j.txt
txt: txt/cord-322760-tsxniu3j.txt
title:
  Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea

summary:
  [17] [18] [19] vs. 9 days [0-24], p = 0.041) and in sporadic MERS cases (12 days vs. 9 days [0-30], p = 0.003). These findings can be attributed to three facts: first, the majority of HCP developed asymptomatic or mild symptoms and moderate symptoms [15] ; second, HCP were confirmed as secondary cases under medical investigation, which led to earlier confirmation and good outcomes [32] ; third, epidemiological analysis showed that HCP were much younger and had fewer co-morbidities compared to total MERS cases [36] .


id: cord-339762-lh8czr0a
author: Ng, Dianna L.
date: 2016-03-31
extension: .txt
mime: text/plain
words: 3211
sentence: 118
flesch: 31
cache: cache/cord-339762-lh8czr0a.txt
txt: txt/cord-339762-lh8czr0a.txt
title:
  Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014

summary:
  Lit Update Risk Assess 7 Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Albarrak AM: Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Al Raiy B: Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Evaluation of pigtail macaques as a model for the effects of copper intrauterine devices on HIV infection Pathology and pathogenesis of fatal Bordetella pertussis infection in infants Fullgenome deep sequencing and phylogenetic analysis of novel human betacoronavirus MRBAYES: Bayesian inference of phylogenetic trees Realtime reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an invitro and ex-vivo study Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Clinical management of severe acute respiratory infection when Middle East respiratory syndrome coronavirus (MERS-CoV) infection is suspected.


id: cord-341795-zbqfs77n
author: Sikkema, R. S.
date: 2019-02-21
extension: .txt
mime: text/plain
words: 5008
sentence: 202
flesch: 51
cache: cache/cord-341795-zbqfs77n.txt
txt: txt/cord-341795-zbqfs77n.txt
title:
  Global status of Middle East respiratory syndrome coronavirus in dromedary camels: a systematic review

summary:
  The publications in this review show that the MERS-CoV mainly circulates in dromedary camel populations in the Middle East and part of Africa, and has been infecting dromedary camels in Africa for more than three decades. In total, 33 papers describe camel studies in the Middle East, 13 studies investigated camels from Africa and the remaining seven surveys were from Spain, Australia, Japan, Bangladesh and Pakistan (Table 1) .


id: cord-340836-eb5a9ln3
author: Aghazadeh-Attari, Javad
date: 2018-04-06
extension: .txt
mime: text/plain
words: 2695
sentence: 102
flesch: 46
cache: cache/cord-340836-eb5a9ln3.txt
txt: txt/cord-340836-eb5a9ln3.txt
title:
  Epidemiological factors and worldwide pattern of Middle East respiratory syndrome coronavirus from 2013 to 2016

summary:
  In summary, these findings point to interesting and potential dimensions of the dynamic evolution of this disease, and the need for further studies on genetic features of the culprit virus and the epidemiological parameters and risk factors of MERS-CoV mortality is also emphasized. Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Person-to-person spread of the MERS coronavirus-an evolving picture Evidence for camel-to-human transmission of MERS coronavirus Evidence for camel-to-human transmission of MERS coronavirus This work was funded by the Urmia University of Medical Sciences (grant number 2122).


id: cord-318585-cp76qr9f
author: Matsuyama, Ryota
date: 2016-11-29
extension: .txt
mime: text/plain
words: 4500
sentence: 180
flesch: 43
cache: cache/cord-318585-cp76qr9f.txt
txt: txt/cord-318585-cp76qr9f.txt
title:
  Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis

summary:
  These risks showed a substantial heterogeneity among the identified studies, and appeared to be the highest in case studies focusing on ICU cases. In ICU case studies, the expected odds ratios (OR) of death among patients with underlying heart disease or renal disease to patients without such comorbidities were 0.6 (95% Confidence Interval (CI): 0.1, 4.3) and 0.6 (95% CI: 0.0, 2.1), respectively, while the ORs were 3.8 (95% CI: 3.4, 4.2) and 2.4 (95% CI: 2.0, 2.9), respectively, in studies with other types of designs.


id: cord-349010-n4s8dzgp
author: Al-Tawfiq, Jaffar A.
title: Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
date: 2016-12-24
extension: .txt
mime: text/plain
words: 4276
sentence: 204
flesch: 44
cache: cache/cord-349010-n4s8dzgp.txt
txt: txt/cord-349010-n4s8dzgp.txt
summary:
  A review of MERS-CoV in healthcare setting Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in healthcare settings Middle East respiratory syndrome coronavirus (MERS-CoV) n d Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Oxford centre for evidence-based medicine -levels of evidence Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays • A study of the inhibitors of MERS-CoV Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection Treatment with lopinavir/ ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset • A primate model of MERS-CoV infection Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Middle East respiratory syndrome coronavirus (MERS-CoV) infection mediated by the transmembrane serine protease TMPRSS2 Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Cyclosporin A inhibits the replication of diverse coronaviruses Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) Mycophenolic acid augments interferon-stimulated gene expression and inhibits hepatitis C virus infection in vitro and in vivo Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Passive transfer of A Germline-like neutralizing human monoclonal antibody protects transgenic mice against lethal Middle East respiratory syndrome coronavirus infection Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection Treatment with interferon-alpha 2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study The first study of interferon and ribavirin in MERS-CoV Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study •• A large cohort study of ribavirin-interferon in MERS-CoV patients Acute management and longterm survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Combination therapy with lopinavir/ ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Middle East respiratory syndrome coronavirus during pregnancy Middle Eastern Respiratory Syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Guidelines for the laboratory diagnosis of Middle East respiratory syndrome coronavirus in Korea Inhibition of Middle East respiratory syndrome coronavirus (MERS-CoV) infection by anti-CD26 monoclonal antibody Pre-and postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV The multifunctional or moonlighting protein CD26/DPPIV Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A Successful treatment of avianorigin influenza A (H7N9) infection using convalescent plasma Successful treatment of avian influenza with convalescent plasma The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) into the United States Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol Antibody response and disease severity in healthcare worker MERS survivors Transmission of MERScoronavirus in household contacts Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection •• A study of viral shedding of MERS-CoV Kinetics of serologic responses to mers coronavirus infection in humans Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Clinical recommendations from an observational study on MERS:


id: cord-344954-gpb25fga
author: Hashem, Anwar M
date: 2019-11-15
extension: .txt
mime: text/plain
words: 5176
sentence: 178
flesch: 37
cache: cache/cord-344954-gpb25fga.txt
txt: txt/cord-344954-gpb25fga.txt
title:
  A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model

summary:
  The fusion gene was then used to generate the proposed rAd5 construct (rAd5-S1/F/CD40L) in addition to rAd5 vaccines expressing secreted and consensus S1 protein alone (rAd5-S1) and a vector control expressing Green Fluorescent Protein (rAd5-GFP) as shown in Figure 1 . Vero E6 and Huh7.5 cells were cultured and maintained in complete Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% heat-inactivated fetal bovine serum. Schematic representation of Middle East respiratory syndrome coronavirus vaccine candidates.


id: cord-312741-0au4nctt
author: Lin, Panpan
title: Coronavirus in human diseases: Mechanisms and advances in clinical treatment
date: 2020-10-01
extension: .txt
mime: text/plain
words: 14692
sentence: 507
flesch: 30
cache: cache/cord-312741-0au4nctt.txt
txt: txt/cord-312741-0au4nctt.txt
summary:
  The 9-kDa hydrophobic protein encoded at the 3' end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated Mouse hepatitis virus gene 5b protein is a new virion envelope protein Infectious bronchitis virus E protein is targeted to the Golgi complex and directs release of virus-like particles A comprehensive comparison of transmembrane domains reveals organelle-specific properties Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer Assembly of the coronavirus envelope: homotypic interactions between the M proteins SARS coronavirus E protein forms cation-selective ion channels Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors The transmembrane domain of the infectious bronchitis virus E protein is required for efficient virus release Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells Role of the coronavirus E viroporin protein transmembrane domain in virus assembly Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis Heterologous gene expression from transmissible gastroenteritis virus replicon particles Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome The small envelope protein E is not essential for murine coronavirus replication A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway Characterization of severe acute respiratory syndrome coronavirus membrane protein Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus Genetic evidence for a structural interaction between the carboxy termini of the membrane and nucleocapsid proteins of mouse hepatitis virus The molecular biology of coronaviruses A structural analysis of M protein in coronavirus assembly and morphology Envelope glycoprotein interactions in coronavirus assembly Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system Coronaviruses: an overview of their replication and pathogenesis Nucleocapsidindependent assembly of coronavirus-like particles by co-expression of viral envelope protein genes Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction The missing link in coronavirus assembly. syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization Identification of in vivointeracting domains of the murine coronavirus nucleocapsid protein Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1 Theoretical aspects of virus capsid assembly Analysis of multimerization of the SARS coronavirus nucleocapsid protein Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein Envelope protein palmitoylations are crucial for murine coronavirus assembly The hydrophobic domain of infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus The coronavirus E protein: assembly and beyond Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes The intracellular sites of early replication and budding of SARS-coronavirus Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer Glycan shield and epitope masking of a coronavirus spike protein observed by cryoelectron microscopy Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains A human homolog of angiotensin-converting enzyme.


id: cord-352527-eeyqh9nc
author: Zhou, Yusen
title: Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
date: 2019-01-14
extension: .txt
mime: text/plain
words: 5878
sentence: 206
flesch: 37
cache: cache/cord-352527-eeyqh9nc.txt
txt: txt/cord-352527-eeyqh9nc.txt
summary:
  An epidemiological outbreak study Outbreak of Middle East respiratory syndrome at tertiary care hospital Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections Family cluster of Middle East respiratory syndrome coronavirus infections Healthcare-associated infections: The hallmark of Middle East respiratory syndrome coronavirus with review of the literature Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: A report of nosocomial transmission Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus Persistence of antibodies against Middle East respiratory syndrome coronavirus Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: A study protocol Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: A single centre experience Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: A phase 1 randomised, double-blind, single-dose-escalation study Prospects for a MERS-CoV spike vaccine Current advancements and potential strategies in the development of MERS-CoV vaccines Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? CoV spike protein: A key target for antivirals Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Reverse genetics with a full-length infectious cDNA of the Middle East Report of two cases & review of the literature MERS-CoV infection in a pregnant woman in Korea Middle East respiratory syndrome coronavirus in pediatrics: A report of seven cases from Saudi Arabia Middle East respiratory syndrome coronavirus infection during pregnancy: A Report of 5 cases from Saudi Arabia An outbreak of Middle East respiratory syndrome coronavirus infection in South Korea Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Discovery of novel bat coronaviruses in south China that use the same receptor as Middle East respiratory syndrome coronavirus Rapid detection of MERS coronavirus-like viruses in bats: Pote1ntial for tracking MERS coronavirus transmission and animal origin Receptor usage of a novel bat lineage C Betacoronavirus reveals evolution of Middle East respiratory syndrome-related coronavirus spike proteins for human dipeptidyl peptidase 4 binding MERS-CoV spillover at the camel-human interface Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation High prevalence of MERS-CoV infection in camel workers in Saudi Arabia The prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) antibodies in dromedary camels in Israel Serologic evidence for MERS-CoV infection in dromedary camels Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Dromedary camels in northern Mali have high seropositivity to MERS-CoV Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia county Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Middle East respiratory syndrome coronavirus: Risk factors and determinants of primary, household, and nosocomial transmission Unusual presentation of Middle East respiratory syndrome coronavirus leading to a large outbreak in Riyadh during 2017 Outbreaks of Middle East respiratory syndrome in two hospitals initiated by a single patient in Daejeon MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea:


id: cord-356113-hmj0qu0v
author: Wiwanitkit, Somsri
title: Korean MERS: A new cross continent emerging infectious disease
date: 2015-10-31
extension: .txt
mime: text/plain
words: 796
sentence: 40
flesch: 63
cache: cache/cord-356113-hmj0qu0v.txt
txt: txt/cord-356113-hmj0qu0v.txt
summary:
  Chest CT findings in MERS South Korea scrambles to contain MERS virus MERS coronaviruses in dromedary camels Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission First patient with MERS in US is improving, but number of cases worldwide doubles in six weeks to 6 May First US MERS-CoV cases underscore need for preparedness Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Spread of MERS to South Korea and China Origin and possible genetic recombination of the Middle East respiratory syndrome coronavirus from the first imported case in China: phylogenetics and coalescence analysis Complete genome sequence of Middle East respiratory syndrome coronavirus (MERS-CoV) from the first imported MERS-CoV case in China Genomic sequencing and analysis of the first imported Middle East respiratory syndrome coronavirus (MERS CoV) in China Imported case of MERS-CoV infection identified in China MERS in South Korea and China: a potential outbreak threat? Middle East respiratory syndrome (MERS) is a new emerging infectious disease that was firstly detected in the Middle East


id: cord-338057-ycmr9prw
author: Lee, Jae Hoon
date: 2015-07-15
extension: .txt
mime: text/plain
words: 1319
sentence: 49
flesch: 41
cache: cache/cord-338057-ycmr9prw.txt
txt: txt/cord-338057-ycmr9prw.txt
title:
  An Appropriate Lower Respiratory Tract Specimen Is Essential for Diagnosis of Middle East Respiratory Syndrome (MERS)

summary:
  Better understanding on MERS Corona virus outbreak in Korea Middle East respiratory syndome Information Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Pathogenesis of Middle East respiratory syndrome coronavirus An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities All patients in Korea acquired their disease in hospital settings where they came in direct or indirect contact with MERS patients.


id: cord-324324-8ybfiz8f
author: Decaro, Nicola
title: Novel human coronavirus (SARS-CoV-2): A lesson from animal coronaviruses
date: 2020-04-14
extension: .txt
mime: text/plain
words: 14950
sentence: 415
flesch: 34
cache: cache/cord-324324-8ybfiz8f.txt
txt: txt/cord-324324-8ybfiz8f.txt
summary:
  After 2002-2003 SARS epidemic, the renovated interest in HCoVs allowed the discovery of two additional viruses, the alphacoronavirus HCoV-NL63 and the betacoronavirus HCoV-HKU1, derived from bats and rodents, respectively (Tao et al., 2017) . NL63 (Tao et al., 2017) .


id: cord-343184-kptkmgdm
author: Crameri, Gary
date: 2016-06-17
extension: .txt
mime: text/plain
words: 1610
sentence: 58
flesch: 40
cache: cache/cord-343184-kptkmgdm.txt
txt: txt/cord-343184-kptkmgdm.txt
title:
  Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus

summary:
  Experimental Infection of Alpacas with MERS-CoV Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Inactivation and safety testing of Middle East respiratory syndrome coronavirus Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health MERS coronavirus in dromedary camel herd, Saudi Arabia Absence of MERS-CoV antibodies in feral camels in Australia: implications for the pathogen's origin and spread Replicative capacity of MERS coronavirus in livestock cell lines Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas We thank Kaylene Selleck, Leah Frazer, Jean Payne, Rachel Arkinstall, and Mahen Perera for providing technical assistance and support for this study. We found no previous MERS-CoV challenge trial reported in alpacas, so we chose a preliminary dose and rechallenge time on the basis of our experience with other virus infection trials for other emerging infectious diseases (8) .


id: cord-348821-2u6ki9dv
author: Xu, Ping
date: 2020-03-10
extension: .txt
mime: text/plain
words: 3334
sentence: 140
flesch: 43
cache: cache/cord-348821-2u6ki9dv.txt
txt: txt/cord-348821-2u6ki9dv.txt
title:
  Clinical Characteristics of Two Human to Human Transmitted Coronaviruses: Corona Virus Disease 2019 versus Middle East Respiratory Syndrome Coronavirus.

summary:
  The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health -the latest 2019 novel coronavirus outbreak in Wuhan, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection Characteristics and outcome of viral pneumonia caused by influenza and Middle East respiratory syndrome-coronavirus infections: A 4-year experience from a tertiary care center Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Emerging Coronavirus 2019-nCoV Pneumonia Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: A cohort study Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study Epidemiological status of the Middle East respiratory syndrome coronavirus in 2019: an update from Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study Mortality rate of ICU patients with the Middle East Respiratory Syndrome -Coronavirus infection at King Fahad Hospital, Jeddah, Saudi Arabia Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea Neurological Complications during Treatment of Middle East Respiratory Syndrome A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea MERS-CoV outbreak in Jeddah--a link to health care facilities Renal Complications and Their Prognosis in Korean Patients with Middle East Respiratory Syndrome-Coronavirus from the Central MERS-CoV Designated Hospital Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Estimating the mean and variance from the median, range, and the size of a sample The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. key: cord-348821-2u6ki9dv authors: Xu, Ping; Sun, Guo-Dong; Li, Zhi-Zhong title: Clinical Characteristics of Two Human to Human Transmitted Coronaviruses: Corona Virus Disease 2019 versus Middle East Respiratory Syndrome Coronavirus.


id: cord-331228-wbd0s4fo
author: Shehata, Mahmoud M.
title: Middle East respiratory syndrome coronavirus: a comprehensive review
date: 2016-01-20
extension: .txt
mime: text/plain
words: 7527
sentence: 314
flesch: 43
cache: cache/cord-331228-wbd0s4fo.txt
txt: txt/cord-331228-wbd0s4fo.txt
summary:
  respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Cyclophilins as modulators of viral replication Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis Testing of Middle East respiratory syndrome coronavirus replication inhibitors for the ability to block viral entry Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The newly emerged SARS-like coronavirus HCoV-EMC also has an Achilles' heel: current effective inhibitor targeting a 3C-like protease Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Mahmoud M. Shehata, Mokhtar R. Gomaa, Mohamed A. Ali, and Ghazi Kayali declare that they have no conflict of interest. respiratory syndrome coronavirus The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Furin at the cutting edge: from protein traffic to embryogenesis and disease MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells SARS-beginning to understand a new virus Wildtype and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Pneumonia from human coronavirus in a macaque model Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Infection with MERS-CoV causes lethal pneumonia in the common marmoset The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Novel coronavirus-Saudi Arabia: human isolate.


id: cord-354272-99vw735a
author: DARLING, N. D.
date: 2017-10-24
extension: .txt
mime: text/plain
words: 3551
sentence: 131
flesch: 45
cache: cache/cord-354272-99vw735a.txt
txt: txt/cord-354272-99vw735a.txt
title:
  Retrospective, epidemiological cluster analysis of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic using open source data

summary:
  The absence of apparent seasonality in the identified clusters further supports the significant role humanto-human transmission in healthcare settings plays in the propagation of MERS-CoV. Classification of each cluster into one or more of the three disease transmission categories (nosocomial, household, or exported) elucidated common characteristics among the clusters, including the overall concentration of case clusters in cities and healthcare institutions. Of the 51 identified clusters, 41 (80·4%) were classified as nosocomial clusters; 12 (23·5%) were household clusters; and eight (15·7%) were exported (Table 3 ).


id: cord-345046-str19r9a
author: Al Ghamdi, Mohammed
date: 2016-04-21
extension: .txt
mime: text/plain
words: 3441
sentence: 181
flesch: 44
cache: cache/cord-345046-str19r9a.txt
txt: txt/cord-345046-str19r9a.txt
title:
  Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia

summary:
  Hospital outbreak of Middle East respiratory syndrome coronavirus State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Jordan MERS-CoV Investigation Team. The severe acute respiratory syndrome Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Patient with new strain of coronavirus is treated in intensive care at London hospital Latest outbreak news from ProMED-mail: novel coronavirus -Middle East Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group WHO summary Family cluster of Middle East respiratory syndrome coronavirus infections KSA MERS-CoV Investigation Team.


id: cord-351685-n70tkf38
author: Altamimi, Asmaa
date: 2020-02-19
extension: .txt
mime: text/plain
words: 3460
sentence: 145
flesch: 52
cache: cache/cord-351685-n70tkf38.txt
txt: txt/cord-351685-n70tkf38.txt
title:
  Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory

summary:
  Similarly, two more single-centre case control studies reported that the presenting symptoms of MERS-CoV infection were not specific [18, 19] . Physicians and public health practitioners need to identify suspected cases which have higher chances of diagnosis as confirmed cases prior to laboratory testing (which usually takes between 12 and 24 hours). Therefore, the identification of suspected cases that may have higher chances of being diagnosed as cases of MERS-CoV is essential.


id: cord-329190-kv9n2qj3
author: Rabaan, Ali A.
title: A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective
date: 2017-09-01
extension: .txt
mime: text/plain
words: 8912
sentence: 420
flesch: 43
cache: cache/cord-329190-kv9n2qj3.txt
txt: txt/cord-329190-kv9n2qj3.txt
summary:
  www.inovio.com/products/ infectious-disease-vaccines/mers A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates MERS-CoV vaccine candidates in development: the current landscape Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Toll-Like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Bioinformatics analysis on molecular mechanism of Ribavirin and interferon-a in treating MERS-CoV Treatment with lopinavir/ritonavir or interferon-b1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Middle Eastern Respiratory syndrome Corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome coronavirus S protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design Small molecules targeting severe acute respiratory syndrome human coronavirus Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Towards improving clinical management of Middle East respiratory syndrome coronavirus infection Ninth Report of the International Committee on Taxonomy of Viruses Cross host transmission in the emergence of MERS coronavirus Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Close relative of human Middle East respiratory syndrome coronavirus in bat MERS-Coronavirus molecular epidemiology and genetic analysis -Origin and evolution MERS coronavirus: diagnostics, epidemiology and transmission Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics Evolutionary dynamics of MERS-CoV: potential recombination, positive selection and transmission MERS-CoV spike protein: a key target for antivirals Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission Protease inhibitors targeting coronavirus and filovirus entry Critical assessment of the important residues involved in the dimerization and catalysis of MERS Coronavirus Main protease Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways Adjunctive therapies and immunomodulating agents for severe influenza Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis SARS: systematic review of treatment effects Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol Treatment strategies for Middle East respiratory syndrome coronavirus Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Evaluation of candidate vaccine approaches for MERS-CoV A conformationdependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Passive transfer of A Germline-like neutralizing human monoclonal antibody protects transgenic mice against Lethal Middle East respiratory syndrome coronavirus infection Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-Specific human monoclonal antibody protects rabbits from MERS-CoV infection Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeatderived peptides Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection A truncated receptorbinding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: implication for designing novel mucosal MERS vaccines Receptor-binding domain-based subunit vaccines against MERS-CoV Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus Recombinant receptor-binding domains of multiple Middle East respiratory syndrome coronaviruses (MERS-CoVs) induce cross-neutralizing antibodies against divergent human and camel MERS-CoVs and antibody escape mutants Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice Toward developing a preventive MERS-CoV Vaccine-Report from a workshop organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute Protective efficacy of recombinant modified vaccinia virus Ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus A highly immunogenic and protective Middle East respiratory syndrome coronavirus vaccine based on a recombinant measles virus vaccine platform An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels GLS-5300 SynCon® immunotherapy targeting Middle East Respiratory Syndrome.


id: cord-017731-xzfo5jjq
author: Todd, Ewen C. D.
title: Foodborne Disease in the Middle East
date: 2016-11-25
extension: .txt
mime: text/plain
words: 25397
sentence: 908
flesch: 48
cache: cache/cord-017731-xzfo5jjq.txt
txt: txt/cord-017731-xzfo5jjq.txt
summary:
  key: cord-017731-xzfo5jjq authors: Todd, Ewen C. D. title: Foodborne Disease in the Middle East date: 2016-11-25 journal: Water, Energy & Food Sustainability in the Middle East DOI: 10.1007/978-3-319-48920-9_17 sha: doc_id: 17731 cord_uid: xzfo5jjq Food safety is a concern worldwide and according to the World Health Organization, developing countries are probably more at risk of foodborne illness because many of these, including those in the Middle East, have limited disease surveillance and prevention and control strategies. Research has been focused on microbial contamination of locally-sold foodstuffs and manager and employee knowledge of food safety and hygienic conditions in food preparation establishments.


id: cord-312692-jv3425w1
author: Iwata-Yoshikawa, Naoko
date: 2019-01-09
extension: .txt
mime: text/plain
words: 8569
sentence: 343
flesch: 50
cache: cache/cord-312692-jv3425w1.txt
txt: txt/cord-312692-jv3425w1.txt
title:
  Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus

summary:
  When we asked why the Tg2 mice showed nonlethal responses to infection, we could not ignore the fact that virus levels in lungs were lower than those reported for other MERS mouse models (5, 12, 13, 38, 39) . (C) Genomic DNA was extracted from Tg2 mice, and human DPP4 exons 1 to 26 were subjected to PCR using specific primers.


id: cord-323087-3cxyogor
author: Widagdo, W.
title: Tissue Distribution of the MERS-Coronavirus Receptor in Bats
date: 2017-04-26
extension: .txt
mime: text/plain
words: 3431
sentence: 125
flesch: 41
cache: cache/cord-323087-3cxyogor.txt
txt: txt/cord-323087-3cxyogor.txt
summary:
  The antibody used in this study recognizes bat DPP4 as was demonstrated in transfection experiments using cloned Pipistrelle bat DPP4 22 . Middle East respiratory syndrome An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Antibodies against MERS coronavirus in dromedary camels Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection Replicative Capacity of MERS Coronavirus in Livestock Cell Lines Circulation of group 2 coronaviruses in a bat species common to urban areas in Western Europe Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Close relative of human Middle East respiratory syndrome coronavirus in bat Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe MERS-related betacoronavirus in Vespertilio superans bats Group C betacoronavirus in bat guano fertilizer Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans


id: cord-349643-jtx7ni9b
author: Uyeki, Timothy M.
title: Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus
date: 2016-07-17
extension: .txt
mime: text/plain
words: 4808
sentence: 116
flesch: 14
cache: cache/cord-349643-jtx7ni9b.txt
txt: txt/cord-349643-jtx7ni9b.txt
summary:
  Interferon alfa-n3 for the treatment of Middle East respiratory syndrome Systematic review of treatment effects Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 Evaluation of SSYA10-001 as a replication inhibitor of SARS, MHV and MERS coronaviruses Anti-infective immunoadhesins from plants Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Anti-MERS-COV convalescent plasma therapy Cows with human chromosomes enlisted to fight hantavirus Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution A conformationdependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in MERS-CoV spike protein Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Coronaviruses-drug discovery and therapeutic options 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Evaluation of candidate vaccine approaches for MERS-CoV A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates Phase I, open label dose ranging safety study of GLS-5300 in healthy volunteers Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant modified vaccinia virus Ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus Evaluation of serologic and antigenic relationships between Middle Eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Camels emit dangerous MERS virus, CSU confirms MERS surges again, but pandemic jitters ease Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice MERS-CoV in upper respiratory tract and lungs of dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Time course of MERS-CoV infection and immunity in dromedary camels High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in United Arab Emirates Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways International Severe Acute Respiratory and Emerging Infection Consortium. In addition, the risk for antibody-dependent enhancement of disease may interrupt the timeline for conducting human clinical trials of MERS CoV vaccines and immunotherapeutics.


id: cord-337066-pztrwvib
author: Choi, Won Suk
title: Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea
date: 2016-06-30
extension: .txt
mime: text/plain
words: 3445
sentence: 154
flesch: 44
cache: cache/cord-337066-pztrwvib.txt
txt: txt/cord-337066-pztrwvib.txt
summary:
  Asymptomatic patients were rare in this outbreak, presumably because confirmatory MERS-CoV tests were performed only for symptomatic patients, although active surveillance of asymptomatic HCWs involved in patient care was conducted at one hospital. The case fatality rate observed in this study was lower than that reported in other studies of previous MERS outbreaks (20.4% vs. 36.5-65%)


id: cord-337825-ujq9mxk7
author: Chen, Bin
title: Overview of lethal human coronaviruses
date: 2020-06-10
extension: .txt
mime: text/plain
words: 13457
sentence: 535
flesch: 43
cache: cache/cord-337825-ujq9mxk7.txt
txt: txt/cord-337825-ujq9mxk7.txt
summary:
  lung injury Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14 +CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus Characterization of novel monoclonal antibodies against MERScoronavirus spike protein Discovery of hydrocarbon-stapled short α-helical peptides as promising Middle East respiratory syndrome coronavirus (MERS-CoV) fusion inhibitors A systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus (MERS-CoV) Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay Current treatment options and the role of peptides as potential therapeutic components for Middle East respiratory syndrome (MERS): a review Cell therapy in acute respiratory distress syndrome Challenges and responses in human vaccine development Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine Expression of B subunit of E. coli heat-labile enterotoxin in the progenies of transgenic tobacco bred by crossing nuclear-and chloroplast-transgenic lines Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice One-Health: a safe, efficient, dual-use vaccine for humans and animals against Middle East respiratory syndrome coronavirus and rabies virus Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation DNA vaccine of SARS-Cov S gene induces antibody response in mice ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments-the importance of immunofocusing in subunit vaccine design Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Disulfiram can inhibit MERS and SARS coronaviruspapain-like proteases via different modes De novo design of α-helical lipopeptides targeting viral fusion proteins: a promising strategy for relatively broad-spectrum antiviral drug discovery Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor New vaccine technologies to combat outbreak situations Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial Potent binding of 2019 novelcoronavirus spike protein by a SARS coronavirus-specific human monoclonalantibody Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies Exceptionally potent neutralizationof Middle East respiratory syndrome coronavirus by human monoclonalantibodies Interaction between heptad repeat 1 and 2 regions inspike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Fusion mechanism of 2019-nCoV andfusion inhibitors targeting HR1 domain in spike protein The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 31870836), and the 1.3.5 Project for Disciplines Excellence, West China Hospital, Sichuan University (ZYYC20005 to W.C.). Epidemiology, genetic recombination, and pathogenesis of coronaviruses Origins and evolution of the global RNA virome Classify viruses-the gain is worth the pain Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease Human coronaviruses: what do they cause? Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS A pneumonia outbreak associated with a new coronavirus of probable bat origin Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV On the origin and continuing evolution of SARS-CoV-2 Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Mutations, recombination and insertion in the evolution of 2019-nCoV SARS and MERS: recent insights into emerging coronaviruses Global epidemiology of bat coronaviruses From SARS to MERS, thrusting coronaviruses into the spotlight Challenges presented by MERS corona virus, and SARS corona virus to global health Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease MERS-CoV as an emerging respiratory illness: a review of prevention methods The Middle East respiratory syndrome (MERS)


id: cord-349287-mwj2qby4
author: Mackay, Ian M.
title: MERS coronavirus: diagnostics, epidemiology and transmission
date: 2015-12-22
extension: .txt
mime: text/plain
words: 14293
sentence: 570
flesch: 47
cache: cache/cord-349287-mwj2qby4.txt
txt: txt/cord-349287-mwj2qby4.txt
summary:
  There are human MERS cases that do not fall into either category of source and it is unclear if these acquired infection through some entirely separate route, or from cases that escaped diagnosis. However, on occasion, even LRT specimens from MERS cases may initially be negative, only to later become positive by RT-PCR [95] .


id: cord-345591-zwh1xj5u
author: Al-Dorzi, Hasan M.
date: 2016-10-24
extension: .txt
mime: text/plain
words: 5885
sentence: 277
flesch: 46
cache: cache/cord-345591-zwh1xj5u.txt
txt: txt/cord-345591-zwh1xj5u.txt
title:
  The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study

summary:
  The hospital mortality of ICU MERS patients was 63.4 % (0 % for the HCWs). According to the IDEP, one unit (Unit A) was designated as the primary receiving unit for MERS patients, because of its geographic location being away from main hospital traffic and because 7 of its 8 rooms were negative-pressure airborne infection isolation rooms (AIIR).


id: cord-331714-2qj2rrgd
author: Lvov, Dimitry Konstantinovich
title: Single-Stranded RNA Viruses
date: 2015-05-29
extension: .txt
mime: text/plain
words: 64305
sentence: 2657
flesch: 46
cache: cache/cord-331714-2qj2rrgd.txt
txt: txt/cord-331714-2qj2rrgd.txt
summary:
  Influenza virus A/Anas acuta/Primorie/730/76(H3N2) isolated from wild ducks in the Maritime Territory Isolation of influenza strains identical to influenza virus A/Anglia/42/72 from semisynanthropic bird species in Rovno Province, the Ukrainian SSR Human and avian viruses of the Hong Kong series Isolation of an influenza virus from a tree sparrow and the infection rate of the virus in wild birds in the mid-Dnieper Region A new avian influenza virus from feral birds in the USSR: recombination in nature? Isolation of influenza A viruses from wild migratory waterfowl in the north of Europian part of the USSR Incidence of influenza virus infection in black-headed gulls Isolation of influenza virus with the antigenic formula Hav4 Nav2 and Hav5 Transmission of infectious pneumonia and its differentiation from swine influenza Investigations on a virus pneumonia of long duration prevalent in pigs Studies on the HVJ (Hemagglutinating virus of Japan) newly isolated from the swine Multiplication and cytopathogenic effect of the hemagglutinating virus of Japan (HVJ) in swine kidney tissue culture Discussion on virus infections of the upper respiratory tract Resemblance of a strain of swine influenza virus to human A-prime strains Investigation of swine respiratory diseases in Lithuania SSR Bulletin of scientific-technical information.


