key: cord-290178-4i0z7ve8
authors: Roncati, Luca; Lusenti, Beatrice; Nasillo, Vincenzo; Manenti, Antonio
title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease
date: 2020-05-24
journal: Ann Hematol
DOI: 10.1007/s00277-020-04098-z
sha: 
doc_id: 290178
cord_uid: 4i0z7ve8

nan

especially the elderly and those with pre-existing health issues or immunocompromised, COVID-19 can progress from mild symptoms or signs, such as low-grade fever, h e a d a c h e , c o n j u n c t i v i t i s , r h i n o r r h e a , a n o s m i a , pharyngodynia, ageusia, cough, chills, myalgia, asthenia, skin rash, nausea vomiting, and diarrhea, to pneumonia, acute respiratory distress syndrome, renal insufficiency, disseminate intravascular coagulation, and multiple organ failure [1] . A marked lymphopenia has been observed in the most serious cases of the disease [2] . EBV belongs to the Herpesviridae family and causes infectious mononucleosis as well as chronic active infections; besides, it can induce various pre-cancerous or cancerous lymphoproliferative disorders, such as mucocutaneous ulcer, Hodgkin lymphoma, Burkitt lymphoma, diffuse large B cell lymphoma, plasmablastic lymphoma, plasma cell myeloma, angioimmunoblastic T cell lymphoma, follicular T cell lymphoma, extranodal NK/T cell lymphoma, and aggressive NK cell leukemia, particularly in immunodeficient and/or post-transplanted patients [3] . In these subjects, the synergic action of EBV and SARS-CoV-2 is assumed to be burden by a very high fatality rate.

Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Fig. 1 An axial plan of the CT scan with contrast medium shows a 6.5 × 5.0 cm mass (a, yellow dashed circle) in the right axillary cable. The in situ hybridization for EBV (EBER probe, × 10 objective) points out several positive blue-stained Hodgkin cells inside the core needle biopsy, taken from the axillary mass (b, on the left), and in the bone marrow specimen (b, on the right). The chest X-ray performed at the patient's bed in isolation hospital room shows a diffuse bilateral interstitial pneumonia (c)

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