item: #1 of 53 id: cord-000718-7whai7nr author: None title: ESP Abstracts 2012 date: 2012-08-22 words: 166798 flesch: 44 summary: Of those, 11 were also positive for tumor cells on cytological smears. At the papillary thyroid cancer progression matrix metalloprotease and specific tissue inhibitors of metalloprotease (TIMP-2) increased in the cytoplasm of tumor cells, but the concentration of TIMP-1 decreased. keywords: activity; acute; adenocarcinoma; age; aim; alk; amplification; analysis; antibodies; antibody; areas; associated; association; benign; biopsies; biopsy; bladder; blood; bone; braf; breast; breast cancer; breast carcinoma; cadherin; cancer; cancer cases; cancer cell; cancer patients; carcinoma; carcinoma cases; cases; cell carcinoma; cell lung; cell lymphoma; changes; chemotherapy; chronic; clinical; colon; colorectal; conclusion; control; correlation; cystic; cytoplasmic; data; dept; detection; development; diagnosis; diameter; differentiation; diffuse; disease; dna; egfr; epithelial; evaluation; examination; expression; expression levels; factor; features; female; fibrosis; findings; fish; follow; gastric; gene; gene expression; grade; group; growth; her2; high; histological; history; hospital; human; ihc; immunohistochemistry; index; infiltration; inflammation; inflammatory; invasion; invasive; involvement; ki67; kidney; left; lesions; levels; like; literature; liver; loss; lung; lung cancer; lymph; lymphoma; male; malignant; markers; mass; material; mean; median; medical; melanoma; metastases; metastatic; method; molecular; months; morphology; mutation; necrosis; negative; neoplasm; neoplastic; new; node; non; normal; nuclear; nuclei; number; objective; outcome; overexpression; p53; paraffin; parameters; pathology; patients; pattern; pcr; positive; positivity; potential; presence; present; primary; prognostic; progression; proliferation; prostate; protein expression; pulmonary; range; receptor; recurrence; renal; report; resection; respectively; response; results; right; risk; role; samples; sarcoma; score; sections; series; serum; significance; situ; size; skin; specific; specimens; spindle; stage; staining; status; stromal; studies; study; surgery; survival; system; therapy; thyroid; time; tissue; total; treatment; tumor cells; tumor grade; tumor size; tumor tissue; tumors; tumour; turkey objective; type; university; value; vascular; vimentin; women; years cache: cord-000718-7whai7nr.txt plain text: cord-000718-7whai7nr.txt item: #2 of 53 id: cord-000849-rrezynbs author: Kumar, Rajesh title: A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C date: 2012-11-15 words: 7540 flesch: 54 summary: It was also tested for the presence of binding anti-V3 antibodies and the data is shown in Figure 1 . After 2 weeks, the cultures were screened (first screening) for the presence of anti-V3 antibodies and 7/48 wells showed high V3 binding reactivity with OD> 2. keywords: antibodies; antibody; binding; cells; clones; ebv; hiv-1; human; library; min; phage; scfv cache: cord-000849-rrezynbs.txt plain text: cord-000849-rrezynbs.txt item: #3 of 53 id: cord-000914-d0bk9gu5 author: Conant, Katelyn L. title: Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi’s sarcoma and P. falciparum malaria date: 2013-03-12 words: 10723 flesch: 11 summary: Given that PfRh5 has neither a transmembrane domain nor a cytoplasmic tail, the probability of trans-signaling is likely to be high since a soluble form of PfRh5 [existing either as a monomer, as part of a bioavailable complex with another pathogen molecule such as PfRipr (Chen et al., 2011) , or as bound to a host handler] could initiate CD147-dependent signaling outcomes that are likely to modify Pf malaria or KSHV infection (Marieb et al., 2004; Xu et al., 2007; Ruiz et al., 2008; Slomiany et al., 2009b; Sidhu et al., 2010; Wu et al., 2011) . Shown here is a region of Pf EMP-1 encoded by FCR3S1.2-var1 (Chen et al., 2000) . keywords: cd147; cd36; cells; endemic; endothelial; et al; falciparum; herpesvirus; host; human; infected; infection; interactions; invasion; kaposi; kshv; malaria; parasite; sarcoma; signaling; virus cache: cord-000914-d0bk9gu5.txt plain text: cord-000914-d0bk9gu5.txt item: #4 of 53 id: cord-001927-jt81i0uc author: Ali, Abdelwahid Saeed title: Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis date: 2015-11-03 words: 13166 flesch: 35 summary: Tumor Virology Program, Abramson Comprehensive Cancer Center Epstein-Barr virus and its replication B cells under influence: transformation of B cells by Epstein-Barr virus Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas Helicobacter pyloriassociated oxidant monochloramine induces reactivation of Epstein-Barr virus (EBV) in gastric epithelial cells latently infected with EBV Activation of latent Epstein-Barr virus by antibody to human IgM Persisting oncogenic herpesvirus induced by the tumour promotor TPA Calcium modulation activates Epstein-Barr virus genome in latently infected cells Expression of Epstein-Barr virus-encoded proteins and B-cell markers in fatal infectious mononucleosis Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state The EBNA2 polyproline region is dispensable for Epstein-Barr virus-mediated immortalization maintenance Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule Signal transduction from the Epstein-Barr virus LMP-1 transforming protein Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses Epstein-Barr virus latent genes EBV strain variation: geographical distribution and relation to disease state Analysis of Epstein-Barr virus gene polymorphisms in normal donors and in virus-associated tumors from different geographic locations Strain variation in Epstein-Barr virus immediate early genes Integral membrane protein 2 of Epstein-barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases Variation in the sequence of Epstein Barr virus nuclear antigen 1 in normal peripheral blood lymphocytes and in Burkitt's lymphomas Epstein-Barr virus genotypes associated with nasopharyngeal carcinoma in southern China Compartmentalization and transmission of multiple epsteinbarr virus strains in asymptomatic carriers Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter? Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas of Greenland Eskimoes Clinicopathological spectrum of Epstein-Barr virus-associated T cell malignancies Pathology and genetics of tumors of hemapoietic and lymphoid tissues Epidemiology of nasopharyngeal carcinoma Epstein-Barr virus infections and Hodgkin's disease: a study of fixed tissues using the polymerase chain reaction The company malaria keeps: how co-infection with Epstein-Barr virus leads to endemic Burkitt lymphoma Epstein-Barr virus infection precedes clonal expansion in Burkitt's and acquired immunodeficiency syndrome-associated lymphoma Pediatric Non-Hodgkin Lymphoma The investigation of Epstein-Barr viral sequences in 41 cases of Burkitt's lymphoma from Egypt: epidemiologic correlations Burkitt's lymphoma in Algeria Burkitt's lymphoma: clinicopathologic features and differential diagnosis Burkitt lymphoma: epidemiological features and survival in a South African centre Down-regulation of the EBV-encoded membrane protein (LMP) in Burkitt lymphomas Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma Is Burkitt's lymphoma sexy enough? AIDS-Related Lymphoma Sporadic Burkitt lymphoma of the jaw: case report and review of the literature Molecular diagnosis of Burkitt's lymphoma Therapeutic interventions for Burkitt's lymphoma in children Adult Burkitt lymphoma: advances in diagnosis and treatment Endemic Burkitt lymphoma of maxillofacial region: results of induction treatment with cyclophosphamide plus methotrexate in West Africa Low-intensity therapy in adults with Burkitt's lymphoma Epidemiology of Hodgkin's disease Elevated antibody titers to Epstein-Barr virus in Hodgkin's disease Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease Epstein-Barr virus and Hodgkin's disease. The mechanism of cell to cell contact between virus releasing cells and noninfected epithelial cells for EBV entering and infection was also reported [193] . keywords: b cells; barr; barr virus; burkitt; carcinoma; cells; disease; ebv; epstein; expression; gastric; gene; hodgkin; infection; latency; latent; lmp1; lymphoma; npc; protein; tumors; virus cache: cord-001927-jt81i0uc.txt plain text: cord-001927-jt81i0uc.txt item: #5 of 53 id: cord-004675-n8mlxe7p author: None title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2019-02-26 words: 86609 flesch: 43 summary: Background: Patients with primary immune deficiencies characterized by severe T lymphopenia and/or poor T cell function and patients posthematopoietic cell transplantation are at high risk of severe viral infections. In this study, we investigated effect of IL12R1 mutation in IL-12/IFNaxis by evaluation of patients whole blood cell response to IL-12 and IFN-, IL-12R1 expression in PBMCs and T cell blasts. keywords: age; age patients; analysis; anti; antibody; assay; autoimmune; autoimmunity; b cells; background; biopsy; blood; bone; case; cd3; cd4; cgd; chronic; cohort; conclusions; cvid patients; data; defects; development; diagnosis; disease; disorders; dose; ebv; elevated; evaluation; expression; failure; family; female; fever; flow; function; gene; group; heterozygous; history; hsct; human; hypogammaglobulinemia; iga; igg; igm; immune; immunodeficiency; immunoglobulin; infants; infections; inflammatory; introduction; laboratory; levels; life; liver; loss; low; lung; lymphocyte; lymphopenia; male; marrow; medical; methods; months; mutations; negative; nk cells; non; normal; novel; number; patients; phenotype; pid; post; presentation; proliferation; protein; range; recurrent; report; respiratory; response; results; risk; scid; sequencing; severe; specific; stem; studies; study; symptoms; syndrome; t cells; testing; therapy; time; transplant; transplantation; treatment; variant; weeks; years cache: cord-004675-n8mlxe7p.txt plain text: cord-004675-n8mlxe7p.txt item: #6 of 53 id: cord-005435-onghg1o8 author: Zhang, J title: Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid date: 2003-04-17 words: 2880 flesch: 43 summary: Gene expression in the pGEG.GL3 group declined during the first week following sequential injection, but then there was a rebound in gene expression over the subsequent 2 weeks. Cationic lipidic vectors are efficient in gene transfer to pulmonary endothelium via the vascular route; however, gene expression is transient and lasts for only a few days. keywords: cells; ebv; expression; gene; injection; plasmid; transfer cache: cord-005435-onghg1o8.txt plain text: cord-005435-onghg1o8.txt item: #7 of 53 id: cord-005453-4057qib7 author: None title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 words: 276280 flesch: 51 summary: Goals: In the present study, we describe the frequencies of CRE colonization and analyzed its relationship with development of CRE bacteremia and mortality in two different scenarios: stem cell transplant patients (HSCT) and Leukemia patients. The aim of this study was to analyse a single centre experience with HSCT patients requiring ICU admission and the factors affecting outcome. keywords: /kg; acute gvhd; administration; adult patients; age; agvhd; aim; allogeneic hsct; allosct; aml; analysis; anti; asct; associated; atg; autologous; b cells; based; blood; blood cells; blood stem; bone; busulfan; car; cases; cause; cd19; cd34; cd4; cell count; cell depletion; cell disease; cell dose; cell graft; cell lymphoma; cell source; cell therapy; cell transplantation; cells; center; chemotherapy; children; chimerism; chronic gvhd; clinical; cmv; cmv disease; cohort; combination; common; complications; conclusions; conditioning; conditioning regimen; control; count; criteria; csa; csf; cyclophosphamide; data; days; days post; death; declare; development; diagnosis; difference; disclosure; disease; disease patients; disease relapse; dli; donor; donor age; donor chimerism; donor t; donor transplant; dose; early; ebv; ecp; effect; efficacy; engraftment; experience; expression; factors; failure; female; figure; flow; fludarabine; follow; following; free; function; grade; graft; group; group patients; gvhd grade; gvhd patients; gvhd prophylaxis; haploidentical; haploidentical hsct; hct; hematopoietic; high; hla; hospital; host disease; hsct group; hsct patients; hsct recipients; iii; immune; impact; incidence; increase; induction; infection; infusion; intensity; leukemia patients; levels; lymphocyte; lymphoma patients; major; male; marrow; marrow transplantation; matched; mds; mean; median; median os; medical; methods; mm patients; mobilization; months; mortality; mrd; msd; mud; multiple; myeloid; myeloma patients; n=1; negative; neutrophil; nhl patients; nk cells; non; nrm; number; option; outcome; overall; patients; patients age; patients background; patients characteristics; pbsc; pcr; pediatric; period; pfs; pgf patients; phase; platelet; population; positive; post; post transplant; potential; pre; present; previous; primary; prior; procedure; progression; protocol; ptcy; pts; range; rate; ratio; reactivation; received; reconstitution; recovery; reduced; refractory; regimen; relapse; remission; response; results; retrospectively; risk patients; safety; samples; sc patients; second; secondary; serum; severe; sibling; specific; standard; status; stem cell; steroid; studies; study; study patients; survival; syndrome; system; t cells; table; term; test; therapy; time; total; toxicity; transplant patients; transplantation background; transplanted; treatment; tumor; type; underwent; unrelated; use; versus; vod; years cache: cord-005453-4057qib7.txt plain text: cord-005453-4057qib7.txt item: #8 of 53 id: cord-005460-ezrn8cva author: None title: Physicians – Poster Session date: 2017-07-28 words: 287532 flesch: 53 summary: After three months of treatment patient showed an increase in T cells count (CD3, 411/mmc), and a decrease of toxic metabolites: AXP, 1.652 micromol/ml RBC; dAXP, 0.011 micromol/ml RBC; %dAXP, 0.7 maternal T-cell engraftment persists, despite a good response to the PEG-ADA therapy. Moreover, caspases pathway was significantly activated in thawing CD3+, CD56+ and CD14 + cells: FLICA+ cells % in thawing cells were, respectively, 16.8%, 31.1% and 6.2% vs 3%, 9.7% and o1% in fresh cells. keywords: acute gvhd; adult patients; age; aim; allogeneic; allogeneic hsct; aml patients; analysis; anti; asct; associated; atg; autologous; based; beam; blood; blood cell; blood stem; bone; busulfan; cases; cause; cd34; cell count; cell disease; cell dose; cell lymphoma; cell source; cell therapy; cell transplantation; cells; center; chemotherapy; children; chimerism; chronic gvhd; clinical; cmv; cohort; collection; complete; complications; conditioning; conditioning regimen; conflict; consecutive; control; cord; count; cr patients; criteria; csf; cyclophosphamide; data; days; death; development; diagnosis; difference; disclosure; disease; disease relapse; disease risk; dli; donor; donor cell; donor hsct; dose; early; ebv; ecp; effect; efficacy; engraftment; experience; factors; failure; female; figure; fludarabine; follow; following; free; function; grade; graft; group; group patients; gvhd; gvhd grade; gvhd patients; gvhd prophylaxis; haploidentical; hct; hematology; hematopoietic; high; hla; hospital; host disease; hr =; hsct patients; hsct recipients; iii; immune; impact; incidence; increase; induction; infection; infusion; intensity; interest; leukemia patients; levels; line; lymphoma patients; major; male; malignancies; marrow; marrow transplantation; matched; mds patients; mean; median; median follow; median os; melphalan; mobilization; months; mortality; mrd; mud; myeloablative; myeloid; myeloma patients; n =; negative; neutrophil; nk cell; non; nrm; number; outcome; overall; p =; patients; patients characteristics; patients relapse; pbsc; pediatric; period; pfs; platelet; population; positive; post; post hsct; post transplant; potential; pre; primary; prior; procedure; progression; pts; range; rate; reactivation; receiving; recipients; recovery; refractory; regimen; relapse; related; remission; report; respectively; response; results; ric; risk group; risk patients; score; second; secondary; setting; severe; sibling; significant; specific; standard; status; stem cell; steroid; studies; study; survival; syndrome; t cell; table; tbi; term; therapy; time; tma patients; total; toxicity; transplant patients; transplanted; treatment; trm; type; underwent; university; unrelated; use; versus; vod; years cache: cord-005460-ezrn8cva.txt plain text: cord-005460-ezrn8cva.txt item: #9 of 53 id: cord-006466-e1phpqes author: None title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2018-04-23 words: 92405 flesch: 42 summary: Despite defective T cell signaling responses to chemokines (i.e., GPCR stimulation), chemotaxis of patient T cell blasts in vitro was normal. Proteasome assembly and catalytic function was assessed by SDS-PAGE and native gel respectively, using patient derived cell lines. keywords: age; analysis; antibody; autoimmune; b cells; background; blood; case; cd3; cd4; cd8; cgd; children; chronic; clinical; complications; conclusions; counts; cvid patients; cytometry; data; day; days; development; diagnosis; disease; disorders; dna; evaluation; expression; flow; function; gene; hct; heterozygous; history; hospital; hsct; hypogammaglobulinemia; iga; igg; igm; immune; immunodeficiency; immunoglobulin; infections; inflammatory; introduction; laboratory; levels; life; low; lung; lymphocyte; lymphopenia; marrow; mean; median; methods; months; mutation; negative; nk cells; non; normal; novel; number; objectives; onset; patients; phenotype; pid; population; positive; post; present; presentation; primary; protein; pulmonary; range; recurrent; reduced; replacement; report; response; results; scid; scid patients; sequencing; serum; skin; specific; studies; study; symptoms; syndrome; t cells; testing; therapy; time; total; transplant; treatment; vaccine; variant; weeks; years cache: cord-006466-e1phpqes.txt plain text: cord-006466-e1phpqes.txt item: #10 of 53 id: cord-009997-oecpqf1j author: None title: 2018 ASPHO ABSTRACTS date: 2018-03-31 words: 182444 flesch: 45 summary: Of included patients, 165 had treatment intensity of 2 (41.0%), 192 of 3 (47.8%) and 45 of 4 (11.2%). After 2 cycles of treatment patient was no longer requiring oxygen and was ambulating without assistance. keywords: acute; addition; adherence; adult patients; age; aml; aml patients; analysis; anemia; anti; average; background; baseline; biopsy; bleeding; blood; blood cell; bone; cancer; cancer patients; care; cases; cell; cell disease; center; chart; chemotherapy; childhood; children; chronic; clinical; cohort; complications; conclusion; control; count; course; cycles; data; days; death; design; development; diagnosis; differences; disease; dose; effects; efficacy; end; episodes; evaluation; events; evidence; expression; factors; failure; family; female; fever; findings; following; function; gene; grade; group; guidelines; health; hemoglobin; high; history; hospital; hsct patients; hydroxyurea; imaging; immune; impact; improvement; incidence; increase; induction; infection; initial; institution; intervention; iron; laboratory; lesions; leukemia; levels; life; literature; liver; loss; low; lymphoma; male; management; marrow; mean; median; medical; metastatic; method; months; mortality; multiple; mutations; n =; need; negative; neuroblastoma; neuroblastoma patients; neutropenia; new; non; normal; novel; number; objectives; oncology patients; outcomes; p =; pain; parents; patients; pediatric; period; platelet; population; positive; post; potential; present; presentation; primary; program; providers; range; rates; relapse; report; required; research; response; results; review; risk; risk patients; role; scd patients; scores; screening; severe; sickle; sirolimus; specific; stage; standard; states; states background; stem; studies; study; support; survival; survivors; symptoms; syndrome; term; testing; therapy; thrombocytopenia; time; total; transfusion; transplant; treatment; tumor; type; united; use; weeks; years cache: cord-009997-oecpqf1j.txt plain text: cord-009997-oecpqf1j.txt item: #11 of 53 id: cord-015306-us58wwmp author: None title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 words: 71292 flesch: 48 summary: The purpose of this study was to determine the diagnostic performance of the application of questionnaires to detect ADHD and other psychiatric disorders in children with functional voiding disorders in general pediatrics consultations Methods: The study was conducted on 32 children between 6 and 13 years of age (20 males) diagnosed with FVD (patient group) and 32 children of the same age (21 males) who had no urinary symptoms (control group). Conclusion: Converting from a CNI based immunosuppressant protocol for Paediatric renal transplantation patients to a Sirolimus based one was effective and the benefit was shown up to 54 months post-transplantation One patient received a desensitisation regime with Rituximab and plasmaexhange pre-transplant and IV immunoglobulin post-operatively. keywords: abstract; acute; age; aki; analysis; biopsy; bladder; blood; cases; cells; children; chronic; ckd; conclusion; control group; correlation; creatinine; data; days; dialysis; difference; disease; dose; ebv; effect; enuresis; expression; factors; failure; findings; follow; function; gene; glomerular; grade; graft; group; group b; growth; hospital; hsp; igan; infection; injury; kidney; kidney disease; kidney injury; levels; mean; median; medical; methods; model; months; mutations; nephrology; nephropathy; nocturnal; non; objective; patients; pediatric; period; post; primary; proteinuria; range; rate; rats; recipients; renal; results; risk; role; serum; stage; study; study group; survival; syndrome; term; therapy; time; total; transplantation; treatment; treatment group; tubular; university; urinary; urine; vur; weeks; weight; years cache: cord-015306-us58wwmp.txt plain text: cord-015306-us58wwmp.txt item: #12 of 53 id: cord-016255-kkko1xne author: van der Meer, J.T.M. title: 14 Intravasale infecties en sepsis date: 2011 words: 7440 flesch: 50 summary: Een goede indruk van de relevantie van een CMV-infectie is in die gevallen te verkrijgen door het meten van de hoeveelheid viraal DNA in bloed of plasma. Een bespreking van de aangrijpingspunten van antivirale therapie is te vinden in hoofdstuk 1 (paragraaf 1.7.2). keywords: aantal; acute; als; antistoffen; bij; bloed; cd4; cellen; cmv; dan; dat; deze; die; dit; door; ebv; een; fase; gepaard; gevolg; geïnfecteerde; het; hiv; hiv-2; hoeveelheid; hoofdstuk; infectie; kan; komt; kunnen; lymfadenopathie; maar; meer; men; niet; ook; patiënten; plasma; primaire; tegen; tijdens; tot; transmissie; uit; van; virale; virus; virussen; vooral; werd; worden; wordt; zich; ziekte; zijn; zoals cache: cord-016255-kkko1xne.txt plain text: cord-016255-kkko1xne.txt item: #13 of 53 id: cord-016932-bej10xbf author: Lum, Lawrence G. title: Specific Adoptive T-Cell Therapy for Viral and Fungal Infections date: 2018-06-19 words: 8107 flesch: 32 summary: Four major approaches were used: (1) stimulation with viral antigen(s) during ex vivo culture of donor T cells from peripheral blood mononuclear cells (PBMC), (2) direct selection of donor cells, (3) genetic modification of T cells to confer specific recognition of pathogen or pathogen-infected cells, or (4) arming of ex vivo expanded T cells with bispecific antibody to target the viral antigen ( Fig. 20.1 ). The Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation The history of vaccination against cytomegalovirus Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy Clinical aspects of CMV infection after stem cell transplantation Cytomegalovirus and varicellazoster virus vaccines in hematopoietic stem cell transplantation Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation The use of anti-CD3 and anti-CD28 monoclonal antibodies to clone and expand human antigen-specific T cells Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy T-cell therapy in the treatment of post-transplant lymphoproliferative disease Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation Large-scale expansion of dendritic cell-primed polyclonal human cytotoxic T-lymphocyte lines using lymphoblastoid cell lines for adoptive immunotherapy Analysis of CD8 T cell reactivity to cytomegalovirus using protein-spanning pools of overlapping pentadecapeptides Expansion of T cells targeting multiple antigens of cytomegalovirus, Epstein-Barr virus and adenovirus to provide broad antiviral specificity after stem cell transplantation Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor A phase I-II trial to examine the toxicity of CMV-and EBV-specific cytotoxic T lymphocytes when used for prophylaxis against EBV and CMV disease in recipients of CD34-selected/T cell-depleted stem cell transplants Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients Administration of neomycin-resistance-genemarked EBV-specific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts Immunotherapy targeting EBV-expressing lymphoproliferative diseases Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection Adoptive immunotherapy for posttransplantation viral infections Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virusspecific T-cell lines Generation of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapy Rapidly generated multivirus-specific cytotoxic T lymphocytes for the prophylaxis and treatment of viral infections Naïve T-cell-derived CTL recognize atypical epitopes of CMVpp65 with higher avidity than CMVseropositive donor-derived CTL -a basis for treatment of post-transplant viral infection by adoptive transfer of T-cells from virus-naïve donors Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets The role of virus-specific adoptive T-cell therapy in hematopoietic transplantation Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor-and virus-derived antigens Adoptive transfer and selective reconstitution of streptamerselected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation Immunobiology : the immune system in health and disease Adoptive cellular therapy: a race to the finish line The promise and potential pitfalls of chimeric antigen receptors Tumor-specific T-bodies: towards clinical application CMV-specific TCR-transgenic T cells for immunotherapy Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity Development of genetically engineered CD4+ and CD8+ T cells expressing TCRs specific for a M. tuberculosis 38-kDa antigen Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosa Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific alphabeta TCR genes T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120 Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells Characterization of T cell-expressed chimeric receptors with antibodytype specificity for the CD4 binding site of HIV-1 gp120 Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLApeptide tetramers Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation Directly selected cytomegalovirus-reactive donor T cells confer rapid and safe systemic reconstitution of virus-specific immunity following stem cell transplantation Reconstitution of EBV-specific T cell immunity in solid organ transplant recipients Complete regression of posttransplant lymphoproliferative disease using partially HLA-matched Epstein Barr virus-specific cytotoxic T cells Treatment of Epstein-Barr-virus-positive post-transplantation lymphoproliferative disease with partly HLAmatched allogeneic cytotoxic T cells Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial A novel haploidentical adoptive CTL therapy as a treatment for EBV-associated lymphoma after stem cell transplantation Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells Successful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytes Successful treatment of a classic Hodgkin lymphoma-type posttransplant lymphoproliferative disorder with tailored chemotherapy and Epstein-Barr virus-specific cytotoxic T lymphocytes in a pediatric heart transplant recipient Thirdparty virus-specific T cells eradicate adenoviraemia but trigger bystander graft-versus-host disease Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient Rapid salvage treatment with virus-specific T cells for therapyresistant disease Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation Monoculturederived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals Prophylactic infusion of cytomegalovirusspecific cytotoxic T lymphocytes stimulated with Ad5f35pp65 gene-modified dendritic cells after allogeneic hemopoietic stem cell transplantation Multicenter study of banked third-party virusspecific T cells to treat severe viral infections after hematopoietic stem cell transplantation Safety and clinical efficacy of rapidly-generated trivirus-directed T cells as treatment for adenovirus, EBV, and CMV infections after allogeneic hematopoietic stem cell transplant Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT Targeted T-cell therapy in stage IV breast cancer: a phase I clinical trial Phase I study of anti-CD3 x anti-Her2 bispecific antibody in metastatic castrate resistance prostate cancer patients Anti-CD3 x anti-EGFR bispecific antibody redirects T cell cytolytic activity to EGFR-positive cancers in vitro and in an animal model T cells armed with anti-CD3 x anti-CD20 bispecific antibody enhance killing of CD20+ malignant B-cells and bypass complement-mediated Rituximab-resistance in vitro CD20-targeted T cells after stem cell transplantation for high risk and refractory non-Hodgkin's lymphoma Multiple infusions of CD20-targeted T cells and low-dose IL-2 after SCT for high-risk non-Hodgkin's lymphoma: a pilot study Targeting cytomegalovirus-infected cells using T cells armed with anti-CD3× anti-CMV bispecific antibody Accelerated production of antigen-specific T cells for preclinical and clinical applications using gas-permeable rapid expansion cultureware (G-Rex) T-cell therapies for HIV Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience Human MHC class I-restricted high avidity CD4 T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo Cord blood T cells retain early differentiation phenotype suitable for immunotherapy after TCR gene transfer to confer EBV specificity Beta-glucan recognition by the innate immune system Immunity to fungal infections Current challenges in the diagnosis and management of invasive fungal infections: report from the 15th international symposium on infections in the immunocompromised host Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus Generation of a multipathogen-specific T-cell product for adoptive immunotherapy based on activation-dependent expression of CD154 Clinicalscale generation of multi-specific anti-fungal T cells targeting Candida, Aspergillus and mucormycetes Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy Robust polyfunctional T-helper 1 responses to multiple fungal antigens from a cell population generated using an environmental strain of Aspergillus fumigatus Generation and characterization of anti-Candida T cells as potential immunotherapy in patients with Candida infection after allogeneic hematopoietic stem-cell transplant Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals CD4+ and CD8+ T cells mediate adoptive immunity to aerosol infection of Mycobacterium bovis bacillus Calmette-Guerin Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen Biochemical and immunological characterization of MP65, a major mannoprotein antigen of the opportunistic human pathogen Candida albicans Characterization of the cellular immune responses to Rhizopus oryzae with potential impact on immunotherapeutic strategies in hematopoietic stem cell transplantation Generation of Epstein-Barr virus-specific cytotoxic T lymphocytes resistant to the immunosuppressive drug tacrolimus (FK506) Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease Acknowledgments Special thanks to the clinical coordinators for dedicating their efforts to serve the immunotherapy patients. keywords: adoptive; adv; allogeneic; cells; cmv; ctls; ebv; hsct; infections; patients; selection; specific; stem; t cells; transplantation; virus cache: cord-016932-bej10xbf.txt plain text: cord-016932-bej10xbf.txt item: #14 of 53 id: cord-018017-c8myq6bi author: Iversen, Patrick L. title: The Threat from Viruses date: 2018-09-30 words: 11576 flesch: 47 summary: Antisense oligonucleotide-based therapy for HIV-1 infection from laboratory to clinical trials Oligodeoxynucleotide phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus A tribute to Sheik Humarr Khan and all the healthcare workers in West Africa who have sacrificed in the fight against Ebola virus disease: mae we hush Inhibition of Norovirus replication by Morpholino oligomers targeting the 5'-end of the genome Marine viruses: truth or dare Cancer virus Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis-North Carolina Approved antiviral drugs of the past 50 years The Eradicatio of smallpox: Edward Jenner and the first and only eradication of a human infectious disease Oseltamivir resistance during treatment of influenza A (H5N1) infection In vitro resistance and in vivo efficacy of antisense oligomer against West Nile virus Outbreak of antiviral drug-resistant influenza A in long-term care facility The perpetual challenge of infectious disease Clonal integration of a polyomavirus in human Merkel cell carcinoma Morpholino oligomers targeting the PB1 and NP genes enhance survival of mice infected with highly pathogenic influenza A H7N7 virus Inhibition of multiple subtypes of influenza a virus in cell cultures with morpholino oligomers Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against Ebola virus and Marburg virus: results of two single ascending dose studies Cytomegalovirus infection and atherosclerosis in candidate of coronary artery bypass graft Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the terminal 3′ stem-loop structure Pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev from human immunodeficiency virus type 1 in the adult male rat following single injections and continuous infusion Phase 2a study of the CCR5 monoclonal antibody PRO 140 administered intravenously to HIV-infected adults Anti-HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibody Oseltamivir for influenza in adults and children: systemic review of clinical study reports and summary of regulatory comments Passive immunity in prevention and treatment of infectious diseases Viral diversity and clonal evolution from unphased genomic data Ecology of viruses in soils: past, present and future perspectives Inhibition of dengue virus serotypes 1 to 4 in cell culture with Morpholino oligomers Inhibition of respiratory Syncitial virus infections in cell cultures and in mice with morpholino oligomers Dissemination, divergence and establishment of H7N9 influenza viruses in China Health impact of globalization: towards global governance Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers Isolation and characterization of a new Vesivirus from rabbits Phosphorothioate analogs of oligodeoxyribonucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus Endogenous retroviruses: with us and against us The value of neuraminidase inhibitors for the prevention and treatment of seasonal influenza: a systematic review of systematic reviews Antisense morpholino oligomers directed against the 5'-end of the genome inhibit coronavirus proliferation and growth Inhibition, escape and attenuation of SARS coronavirus treated with antisense morpholino oligomers Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oliogmers Immunological disorders and malignancies in five young brothers Spillover animal infections and the next human pandemic Deposition rates of viruses and bacteria above the atmospheric boundary layer A prospective monitoring study of cytomegalovirus infection in nonimmunosuppressed critical heart surgery patients Inhibition of acquired immunodeficiency syndrome virus by oligonucleotide methylphosphonates Lymphocytic Choriomeningitis virus infection in FVB mouse produces hemorrhagic disease Ancient Athenian plague proves to be typhoid Inhibition of Measles virus infection in cell cultures by peptide-conjugated Morpholino oligomers Vesivirus viremia and Seroprevalence in humans Virus specific antiviral therapy for controlling severe and fatal outbreaks of feline Calicivirus infection Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge Inhibition of Vesivirus infetions in mammalian tissue culture with antisense morpholino oligomers Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxynucleotide Inhibition of multiple species of picornavirus using a morpholino oligomer targeting highly conserved IRES sequence Increased risk of hepatocellular carcinoma in male hepatiis B surface antigen carriers with chronic hepatitis who have detectable aflatoxin metabolite M1 Viruses in the sea Chemical modifications to phosphorodiamidate Morpholino oligomer antisense molecules targeting VP24 modify their efficacy against Ebola virus infection Use of ChAd3-EBO-Z Ebola virus vaccine in Malian adults with MVA-BN-Filo: a phase I, single-blind, randomized trial, a phase 1b, open label and double blind, doseescallation trial, and a nested, randomized, double-blind, placebo-controlled trial Inhibition of foot-and-mouth disease virus in cell cultures with antisense morpholino oligomers Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture PCR for detection of oseltamivir resistance mutation in influenza A(H7N9) virus IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers Advanced antisense therapies for postexposure protection against lethal filovirus infections Single component AVI-7537 antisense compound provides greater protection than double component AVI-6002 against Lethal Ebola virus infection in Rhesus Monkeys Isolation of an arenavirus closely related to Lassa virus from Mastomys natalensis in south-east Inhibition of coxsackievirus b3 in cell cultures and in mice by Peptide-conjugated morpholino oligomers targeting the internal ribosomal entry site Inhibition of Rous sarcoma virus replication and transformation by a specific oligodeoxynucleotide Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas Effect of early and late GB virus C viremia on survival of HIV-infected individuals: a meta-analysis Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions The focus has been on viral infections because they rely on host ribosomes to produce their proteins, recent emerging infections have been from single-stranded RNA genome viruses, and replication of RNA viruses is error prone. keywords: antisense; antiviral; cell; disease; dna; ebv; et al; genome; hiv; host; human; infected; infections; influenza; inhibition; life; lymphoma; morpholino; oligomers; outbreak; percent; population; rna; studies; table; virus; viruses; years cache: cord-018017-c8myq6bi.txt plain text: cord-018017-c8myq6bi.txt item: #15 of 53 id: cord-022472-q2qtl26d author: Fishman, Jay A. title: Infection in Renal Transplant Recipients date: 2009-05-15 words: 10762 flesch: 32 summary: Fever and neutropenia syndrome with features of infectious mononucleosis, including hepatitis, nephritis, leukopenia, and/or thrombocytopenia • Pneumonia • Gastrointestinal invasion with colitis, esophagitis, gastritis, ulcers, bleeding, or perforation • Hepatitis, pancreatitis, chorioretinitis With the exception of chorioretinitis, the direct clinical manifestations of CMV infection usually occur 1 to 4 months after transplantation; chorioretinitis usually does not begin until later in the transplant course. CMV infection produces a profound suppression of a variety of host defenses, predisposing to secondary invasion by such pathogens as P. jiroveci, Candida and Aspergillus species, and some bacterial infections. keywords: agents; clinical; cmv; diagnosis; disease; donor; ebv; infection; organ; patients; prophylaxis; recipients; rejection; renal; risk; suppression; therapy; transplant; transplantation; virus cache: cord-022472-q2qtl26d.txt plain text: cord-022472-q2qtl26d.txt item: #16 of 53 id: cord-022888-dnsdg04n author: None title: Poster Sessions date: 2009-08-19 words: 189173 flesch: 41 summary: Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines. keywords: + cells; ability; absence; activity; addition; analysis; antibodies; antibody; antigen; apoptosis; apoptotic; assay; associated; autoimmune; b cells; b t; binding; blood; bone; c mice; cancer cells; capacity; cd4; cd8 +; cd8 cells; cd8 t; cell activation; cell activity; cell culture; cell cycle; cell death; cell development; cell differentiation; cell epitopes; cell function; cell level; cell lines; cell membrane; cell population; cell proliferation; cell receptor; cell responses; cell subsets; cell surface; cell tolerance; cell types; cells cells; changes; chronic; class; clinical; colitis; complex; conclusion; contrast; control; control cells; cross; ctl; cytokine; cytokine production; cytometry; cytotoxic t; data; day; days; dcs; deficient; delta t; dendritic; disease; dna; early; effector cells; effector t; effects; elisa; expansion; experiments; expression; expression levels; factor; family; findings; flow; following; formation; function; gamma; gd cells; gd t; gene; gene expression; group; high; hiv; hla; host; human; ifn; ifng; igg; il-10; il-2; il-4; il-6; immune; immunity; increase; independent; induction; infected; infection; inflammation; inflammatory; inhibition; inkt; interaction; intracellular; levels; lps; macrophages; major; marrow cells; mast cells; mechanisms; membrane; memory t; methods; mhc; mice; model; molecules; monocytes; mouse; mouse t; mrna; murine; negative; neutrophils; new; nkt cells; non; normal; novel; number; objectives; pathway; patients; pcr; peptide; peripheral; plasma cells; play; positive; potential; presence; presentation; primary; production; promoter; protein; protein expression; receptors; regulation; regulatory; release; results; role; secretion; serum; signaling; skin; sle; specific; spleen; stem cells; stimulation; studies; study; surface expression; system; t cells; t em; t h; t helper; t lymphocytes; target cells; tcr; test; th1 cells; time; tissue; tlr; tnf; tolerance; transcription; treatment; tumor cells; type; university; vaccination; vaccine; vg9vd2 t; virus; vitro; vivo; work cache: cord-022888-dnsdg04n.txt plain text: cord-022888-dnsdg04n.txt item: #17 of 53 id: cord-023747-mvq6353a author: Ascherio, Alberto title: Epidemiology of Multiple Sclerosis: Environmental Factors date: 2009-12-25 words: 8862 flesch: 37 summary: An overall review of methods and findings Epidemiological study of multiple sclerosis in Western Poland Past exposure to sun, skin phenotype and risk of multiple sclerosis: A case-control study Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic Circle Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins Vitamin D intake and incidence of multiple sclerosis The use of a self-administered questionnaire to assess diet four years in the past Food-based validation of a dietary questionnaire: The effects of week-to-week variation in food consumption Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis The age-range of risk of developing multiple sclerosis: Evidence from a migrant population in Australia Timing of birth and risk of multiple sclerosis: Population based study Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: Implications for establishing a new effective dietary intake recommendation for vitamin D Estimates of optimal vitamin D status Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol Epidemiologic study of multiple sclerosis in Israel A case-control study of the association between socio-demographic, lifestyle and medical history factors and multiple sclerosis How multiple sclerosis is related to animal illness, stress and diabetes Environmental risk factors and multiple sclerosis: A community-based, case-control study in the province of Ferrara Smoking is a risk factor for multiple sclerosis Oral contraceptives and reproductive factors in multiple sclerosis incidence The influence of oral contraceptives on the risk of mulitple sclerosis Cigarette smoking and incidence of multiple sclerosis Cigarette smoking and the progression of multiple sclerosis Parental smoking at home and the risk of childhoodonset multiple sclerosis in children Cigarette smoking and progression in multiple sclerosis Neuropathological changes in chronic cyanide intoxication Immunomodulatory effects of cigarette smoke Effects of tobacco glycoprotein (TGP) on the immune system: II. A controlled investigation of factors in the life history of the Winnipeg patients Epidemiological study of multiple sclerosis in western Poland Milk consumption and multiple sclerosis-an etiological hypothesis Risk factors in multiple sclerosis: A population-based case-control study in Hautes-Pyrenees Nutritional Epidemiology Dietary fat in relation to risk of multiple sclerosis among two large cohorts of women Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients Double-blind trial of linoleate supplementation of the diet in multiple sclerosis Polyunsaturated fatty acids in treatment of acute remitting multiple sclerosis Linoleic acid in multiple sclerosis: Failure to show any therapeutic benefit Linoleic acid and multiple sclerosis: A reanalysis of three double-blind trials Rate of pregnancy-related relapse in multiple sclerosis: Pregnancy in multiple sclerosis group Oral contraceptives and the incidence of multiple sclerosis Recent use of oral contraceptives and the risk of multiple sclerosis A shadow falls on hepatitis B vaccination effort No increase in demyelinating diseases after hepatitis B vaccination Hepatitis B vaccination and the risk of multiple sclerosis Vaccinations and risk of central nervous system demyelinating diseases in adults School-based hepatitis B vaccination programme and adolescent multiple sclerosis Hepatitis B vaccine and risk of relapse after a first childhood episode of CNS inflammatory demyelination Recombinant hepatitis B vaccine and the risk of multiple sclerosis: A prospective study Hepatitis B vaccination and first central nervous system demyelinating event: A case-control study Vaccinations and the risk of relapse in multiple sclerosis. keywords: barr; ebv; epstein; exposure; individuals; infection; ms risk; prevalence; risk; sclerosis; studies; study; virus; vitamin cache: cord-023747-mvq6353a.txt plain text: cord-023747-mvq6353a.txt item: #18 of 53 id: cord-023854-w8kx5n8k author: Schuster, V. title: Virusinfektionen date: 2019 words: 8485 flesch: 42 summary: Diese aktivierten T-Zellen bilden einen großen Anteil der typischen Pfeiffer-Zellen (syn. lymphatische Reizformen, Virozyten) und der teilweise extremen Lymphozytose im In der Mehrzahl der Fälle kommt es hierbei zu einer unterschiedlich ausgeprägten, meist isotonen, selten einer hypertonen Dehydratation. keywords: abb; als; auch; auf; auftreten; bei; bis; blut; cmv; das; dem; der; des; diagnose; die; durch; ebv; eine; erfolgt; fällen; führt; für; hepatitis; herpes; hhv-6; hiv; hsv; häufig; immer; infektion; ist; kann; kindern; kommt; können; meist; mit; mittels; nach; nachweis; nicht; noch; nur; oder; patienten; schweren; sich; sind; sowie; tage; therapie; treten; und; virus; von; vor; vzv; werden; wird; wochen; zellen; zur; über cache: cord-023854-w8kx5n8k.txt plain text: cord-023854-w8kx5n8k.txt item: #19 of 53 id: cord-024651-578c9ut5 author: None title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 words: 84772 flesch: 43 summary: CARD11 deficiency was confirmed by stimulating patient B cells with phorbol 12-myristate 13 acetate (PMA) and ionomycin and immunoblotting for signalling proteins in both the NF-κB (IKKα/β, IκBα, p65) and MAPK (MEK1/2, MKK4, JNK1/2, ERK1/2) pathways as well as cleavage substrates of the MALT1 paracaspase (RELB, CYLD, BCL10, HOIL1). Furthermore, RNA-Seq confirmed the developmental block observed in patient B cells and suggested that B cells were halted at the centroblast to centrocyte transition. keywords: abstract; age; alps; analysis; anti; autoimmune; b cells; biopsy; blood; bone; case; case report; cd4; cd8; cells; cgd; children; chronic; clinical; cohort; conclusion; cvid; data; days; deficiency; diagnosis; disease; disorders; dysregulation; elevated; evaluation; exome; expression; family; features; female; findings; function; gene; genetic; group; heterozygous; hies; high; history; hospital; hsct; iga; igg; igm; immune; immunodeficiency; immunoglobulin; immunology; improvement; infections; inflammatory; introduction; ivig; laboratory; levels; low; lung; lymphocyte; lymphoma; male; manifestations; marrow; memory; methods; months; mutations; non; normal; patients; phenotype; pid; pid patients; pneumonia; positive; post; presentation; primary; protein; range; recurrent; report text; response; results; rituximab; scid; secondary; sequencing; signaling; skin; stat3; studies; study; symptoms; syndrome; t cells; testing; text; therapy; time; total; transplant; treatment; use; variant; weeks; years cache: cord-024651-578c9ut5.txt plain text: cord-024651-578c9ut5.txt item: #20 of 53 id: cord-031252-ji0ef0by author: D'Angelo, Lawrence title: Infectious Disease Problems in Adolescents date: 2020-09-01 words: 7926 flesch: 37 summary: No specific treatment is indicated for clinical infections. Individuals who received the original killed vaccine appear to be still susceptible to measles infection and need to be revaccinated with the contemporary vaccine. keywords: adolescents; cases; complications; diagnosis; disease; hepatitis; illness; infection; measles; mononucleosis; patients; pneumonia; syndrome; therapy; vaccine; virus cache: cord-031252-ji0ef0by.txt plain text: cord-031252-ji0ef0by.txt item: #21 of 53 id: cord-256130-zhlvvuj4 author: Nordén, Rickard title: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation date: 2018-03-06 words: 4856 flesch: 42 summary: When Tacrolimus was the main immunosuppressive treatment, TTV DNA levels were significantly elevated 6–24 months after transplantation as compared with Cyclosporine treatment. To compare results regarding TTV levels between different transplantation centers, it is vital to reliably quantify the concentrations of TTV-DNA in a standardized manner. keywords: dna; ebv; infection; levels; lung; months; patients; pcr; time; transplantation; ttv; virus cache: cord-256130-zhlvvuj4.txt plain text: cord-256130-zhlvvuj4.txt item: #22 of 53 id: cord-257271-jzmwy4yi author: Lin, Jung-Chung title: Inhibitory effects of some derivatives of glycyrrhizic acid against Epstein-Barr virus infection: Structure–activity relationships date: 2008-03-31 words: 4143 flesch: 39 summary: Glycyrrhizin enhances interleukin-10 production by liver dendritic cells in mice with hepatitis History of the endocrine effects of licorice Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine Synthesis of glycyrrhizic acid conjugates containing l-lysine Containing the spread of HIV infection among high-risk groups In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination Inhibition of glycyrrhizic acid on aflatoxin B1-induced cytotoxicity in hepatoma cells A quantitive bioassay for HIV-1 gene expression based on UV-activation: effect of glycyrrhizic acid Inhibition of nuclear factor B is associated with neuroprotective effects of glycyrrhizic acid on glutamate-induced excitotoxicity in primary neurons Glycyrrhizin, an active component of liquorice roots, and replication of SARSassociated coronavirus Development of antiviral therapy for severe acute respiratory syndrome Complementary and alternative therapies in the treatment of chronic hepatitis C: a systematic review Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses Pathobiology of ischaemic stroke: an integrated view On the mechanism of mitochondrial permeability transition induction by glycyrrhetinic acid Glycyrrhizin inhibits the lytic pathway of complement -possible mechanism of its antiinflammatory effect on liver cells in viral hepatitis Nitric oxide down-regulates Epstein-Barr virus reactivation in epithelial cell lines Epstein-Barr virus infections: prospects for treatment Licorice compounds glycyrrhizin and 18␤-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus Induction of inducible nitric oxide synthase expression by 18␤-glycyrrhetinic acid in macrophages Characterization of complement C3 as a glycyrrhizin (GL)-binding protein and the phosphorylation of C3␣ by CK-2, which is potently inhibited by GL and glycyrrhetinic acid in vitro Synthesis and immunomodulating activity of new glycopeptides of glycyrrhizic acid containing residues of l-glutamic acid Mapping of the C3d receptor (CR2) binding site and a neoantigenic site in the C3d domain of the third component of complement Strategies for evaluation of antiviral agents against Epstein-Barr virus in culture Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro Pathogenesis and therapy of Epstein-Barr virus infection: novel therapeutic approaches Comparison of two bromovinyl nucleoside analogs, 1-␤-d-arabinofuranosyl-E-5-(2-bromovinyl)uracil and E-5-(2-bromovinyl)-2 -deoxyuridine, with acyclovir in inhibition of Epstein-Barr virus replication Sequential detection of different antigens induced by Epstein-Barr virus and herpes simplex virus in the same Western blot by using dual antibody probes Epstein-Barr virus: inhibition of replication by three new drugs Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus Comparative efficacy and selectivity of some nucleoside analogs against Epstein-Barr virus hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication Inhibitory effects of acyclic nucleoside phosphonate analogs, including (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, on Epstein-Barr virus replication Structure-activity relationship between (E)-5-(2-bromovinyl)-and 5-vinyl-1-␤-d-arabinofuranosyluracil(BV-araU, V-araU) in inhibition of Epstein-Barr virus replication Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation Some nucleoside analogs with anti-human immunodeficiency virus activity inhibit replication of Epstein-Barr virus Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV/C3d receptor of B cells: sequence homology of gp 350 and C3 complement fragment C3d Identification of an epitope in the major envelope protein of Epstein-Barr virus that mediates viral binding to the B lymphocytes Epstein-Barr virus receptor (CR2) Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a doubleblind, randomized, placebo-controlled phase I/II trial Pathologic characteristics of immunologic injury in primary cultured rat hepatocytes and protective effect of glycyrrhizin in vitro We thank Joseph Pagano for his critical reading and comments on this manuscript. In previous years, we have shown that many nucleoside analogs selectively inhibit replication of Epstein-Barr virus (EBV) in vitro (Lin et al., 1983 (Lin et al., , 1984 (Lin et al., , 1985 (Lin et al., , 1987 (Lin et al., , 1991 (Lin et al., , 1992 Lin and Machida, 1988; keywords: acid; activity; cells; compounds; ebv; epstein; lin; virus cache: cord-257271-jzmwy4yi.txt plain text: cord-257271-jzmwy4yi.txt item: #23 of 53 id: cord-257299-z9u12yqb author: Mansi, N. title: Ear, nose and throat manifestation of viral systemic infections in pediatric patients date: 2009-12-31 words: 5785 flesch: 39 summary: Treatment and prevention Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unit. Premorbid factors and outcome associated with respiratory virus infections in a pediatric intensive care unit Inner ear and facial nerve complications of acute otitis media with focus on bacteriology and virology Malattie delle tonsille palatine e loro trattamento Upper respiratory virus detection without parent-reported illness in children is virus-specific Le basi patogenetiche delle infezioni respiratorie ricorrenti. keywords: acute; cases; children; complications; days; deafness; ebv; illness; infection; papillomatosis; period; treatment; virus cache: cord-257299-z9u12yqb.txt plain text: cord-257299-z9u12yqb.txt item: #24 of 53 id: cord-259194-9zllvfqb author: Cupples, Sandra A. title: Transplant Infectious Disease: Implications for Critical Care Nurses date: 2011-11-02 words: 4470 flesch: 33 summary: It is important to note that treatment of donor infections itself can further increase the potential donor's risk of iatrogenic infection, for example, via the insertion of intravascular catheters for antimicrobial therapy, the administration of immunomodulating medications such as corticosteroids, and prolonged hospitalization. Thus, liver transplant recipients with CMV infections are prone to develop vanishing bile duct syndrome, heart transplants recipients are at risk for coronary artery vasculopathy, lung transplant recipients are at risk for bronchiolitis obliterans, and so forth. keywords: cmv; device; donor; heart; infections; organ; patient; potential; recipients; risk; transplant cache: cord-259194-9zllvfqb.txt plain text: cord-259194-9zllvfqb.txt item: #25 of 53 id: cord-261251-ylvqxpba author: Ansuini, Valentina title: Debate around infection-dependent hemophagocytic syndrome in paediatrics date: 2013-01-16 words: 4651 flesch: 13 summary: Familial hemophagocytic lymphohistiocytosis and viral infections Familial haemophagocytic reticulosis Incidence in Sweden and clinical features of familial hemophagocytic lymphohistiocytosis Clinical and epidemiologic studies of familial hemophagocytic lymphohistiocytosis in Japan Hemophagocytic lymphohistiocytosis: diagnosis, pathophysiology, treatment, and future perspectives Hemophagocytic syndromes and infection Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onsetjuvenile idiopathic arthritis First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome Infection and malignancy associated hemophagocytic syndromes. key: cord-261251-ylvqxpba authors: Ansuini, Valentina; Rigante, Donato; Esposito, Susanna title: Debate around infection-dependent hemophagocytic syndrome in paediatrics date: 2013-01-16 journal: BMC Infect Dis DOI: 10.1186/1471-2334-13-15 sha: doc_id: 261251 cord_uid: ylvqxpba BACKGROUND: Hemophagocytic syndrome (HPS) is clinically defined as a combination of fever, liver dysfunction, coagulation abnormalities, pancytopenia, progressive macrophage proliferation throughout the reticuloendothelial system, and cytokine over-production, and may be primary or secondary to infectious, auto-immune, and tumoral diseases. keywords: cases; cell; clinical; ebv; hps; infection; lymphohistiocytosis; patients; syndrome; treatment; virus cache: cord-261251-ylvqxpba.txt plain text: cord-261251-ylvqxpba.txt item: #26 of 53 id: cord-266218-r6xg9zts author: Law, Arjun Datt title: Reduced-Intensity Conditioning and Dual T Lymphocyte Suppression with Antithymocyte Globulin and Post-Transplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplants for Hematological Malignancies date: 2018-08-07 words: 4374 flesch: 43 summary: Reduced-intensity conditioning with fludarabine, reduceddose busulfan, and TBI (200 cGy) is a low-toxicity regimen that induces sufficient immunosuppression to permit donor hematopoietic cells to consistently engraft despite the HLAhaplotype barrier. Donor memory T cells are relatively protected from PTCy and provide donor immunity in addition to immune reconstitution post-transplant [13] . keywords: acute; cell; conditioning; days; disease; donor; graft; gvhd; patients; transplantation cache: cord-266218-r6xg9zts.txt plain text: cord-266218-r6xg9zts.txt item: #27 of 53 id: cord-268207-4dabwcfi author: Maakaroun, Nadine Rouphael title: Viral infections associated with haemophagocytic syndrome date: 2010-02-01 words: 6086 flesch: 25 summary: FHL Study Group of the Histiocyte Society Hemophagocytic syndrome: a review of 18 pediatric cases Clinical features and treatment strategies of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis Molecular analysis of latent membrane protein 1 in patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan Severe Epstein-Barr virus-associated hemophagocytic syndrome in six adult patients Poor outcomes of chronic active Epstein-Barr virus infection and hemophagocytic lymphohistiocytosis in non-Japanese adult patients Infection of T lymphocytes in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children of non-Asian origin Fulminant course of infectious mononucleosis with virus-associated hemophagocytic syndrome Cell type specific infection of Epstein-Barr virus (EBV) in EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome Persistent cervical lymphadenopathy in an adolescent with Epstein-Barr induced hemophagocytic syndrome: manifestations of a rare but often fatal disease Epstein-Barr virus-infected natural killer cell leukemia Hemophagocytic syndrome in Epstein-Barr virus-associated Tlymphoproliferative disorders: disease spectrum, pathogenesis, and management Immunophenotypic analysis of Epstein-Barr virus (EBV)-infected CD8(+) T cells in a patient with EBVassociated hemophagocytic lymphohistiocytosis Epstein-Barr virus LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the pathogenesis of hemophagocytic syndrome Biomarker and morphological characteristics of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis X-linked lymphoproliferative disease: a progressive immunodeficiency Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease Monitoring of cell-free viral DNA in primary Epstein-Barr virus infection Viral load in Epstein-Barr virus-associated hemophagocytic syndrome Quantitative analysis of cell-free Epstein-Barr virus genome copy number in patients with EBV-associated hemophagocytic lymphohistiocytosis EBV associated hemophagocytic lymphohistiocytosis with spontaneous regression Treatment strategies for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis Immunosuppressive therapy with antithymocyte globulin and cyclosporine for prolonged marrow failure after hemophagocytic syndrome Splenectomy in haemophagocytic lymphohistiocytosis: report of histopathological changes with CD19+ B-cell depletion and therapeutic results The efficacy of therapeutic plasmapheresis for the treatment of fatal hemophagocytic syndrome: two case reports Pseudomonal supraglottitis occurring in a patient with profound neutropenia secondary to virus-associated haemophagocytic syndrome Use of rituximab in conjunction with immunosuppressive chemotherapy as a novel therapy for Epstein Barr virus-associated hemophagocytic lymphohistiocytosis A boy with fever, lymphadenopathy, hepatosplenomegaly, and lymphocytosis Allogeneic hematopoietic stem cell transplantation for patients with hemophagocytic syndrome (HPS) in Japan Longitudinal follow-up of patients with Epstein-Barr virusassociated hemophagocytic lymphohistiocytosis Cytomegalovirus-associated hemophagocytic syndrome Cytomegalovirus infectionassociated hemophagocytic syndrome Cytomegalovirus infections associated hemophagocytic lymphohistiocytosis in a premature infant Cytomegalovirus ileitis and hemophagocytic syndrome associated with use of anti-tumor necrosis factor-alpha antibody Hemophagocytic syndrome caused by fulminant ulcerative colitis and cytomegalovirus infection: report of a case Cytomegalovirus-associated hemophagocytic syndrome in a patient with adult onset Clinicopathologic study of 56 autopsies Hemophagocytic lymphohistiocytosis: an unusual initial presentation of acute HIV infection Hemophagocytic syndrome in a patient with acute human immunodeficiency virus infection Acute human immunodeficiency virus syndrome presenting with hemophagocytic lymphohistiocytosis Candidiasisassociated hemophagocytic lymphohistiocytosis in a patient infected with human immunodeficiency virus Successful recovery from human immunodeficiency virus (HIV)-associated haemophagocytic syndrome treated with highly active anti-retroviral therapy in a patient with HIV infection Reactive hemophagocytosis associated with the initiation of highly active antiretroviral therapy (HAART) in a patient with Hemophagocytic syndrome after highly active antiretroviral therapy initiation: a life-threatening event related to immune restoration inflammatory syndrome? Reconstitution inflammatory syndrome related to histoplasmosis, with a hemophagocytic syndrome in HIV infection Influenza A and the virus associated haemophagocytic syndrome: cluster of three cases in children with acute leukaemia Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treatment An outbreak of influenza A in a neonatal intensive care unit Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2) keywords: barr; cases; cells; ebv; hemophagocytic; hps; infection; lymphohistiocytosis; patients; syndrome; treatment; virus cache: cord-268207-4dabwcfi.txt plain text: cord-268207-4dabwcfi.txt item: #28 of 53 id: cord-275903-sfrpfy5g author: Yu, Fenggang title: The other side of the coin: Leveraging Epstein–Barr virus in research and therapy date: 2016-07-21 words: 4482 flesch: 32 summary: Virus particles in cultured lymphoblasts from Burkitt's lymphoma Epstein-Barr virus Observations on childhood infections with the Epstein-Barr virus Primary Epstein-Barr virus infections in children EBV persistence in memory B cells in vivo Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8+ T cell immunity Progress and problems in understanding and managing primary Epstein-Barr virus infections Innate immune modulation in EBV infection The role of Epstein-Barr virus in epithelial malignancies Activation of expression of latent Epstein-Barr herpesvirus after gene transfer with a small cloned subfragment of heterogeneous viral DNA The Epstein-Barr virus Rta protein activates lytic cycle genes and can disrupt latency in B lymphocytes ZEBRA cell-penetrating peptide as an efficient delivery system in Candida albicans MD11-mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells EBNA1 and host factors in Epstein-Barr virus latent DNA replication Human artificial episomal chromosomes for cloning large DNA fragments in human cells Gene expression in mammalian cells and its applications Rapid generation of stable cell lines expressing corticotropin-releasing hormone receptor for drug discovery Long-term stability of large insert genomic DNA episomal shuttle vectors in human cells Establishment of an oriP/EBNA1-based episomal vector transcribing human genomic beta-globin in cultured murine fibroblasts Chromatin-binding regions of EBNA1 protein facilitate the enhanced transfection of Epstein-Barr virus-based vectors High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells Up to 100-fold increase of apparent gene expression in the presence of Epstein-Barr virus oriP sequences and EBNA1: implications of the nuclear import of plasmids Rational vector design and multi-pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/l by transient transfection under serum-free conditions 100-liter transient transfection Recombinant protein production by large-scale transient gene expression in mammalian cells: state of the art and future perspectives Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination Improvement of nonviral gene therapy by Epstein-Barr virus (EBV)-based plasmid vectors Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Human induced pluripotent stem cells free of vector and transgene sequences An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells Lymphoblastoid cell lines: a continuous in vitro source of cells to study carcinogen sensitivity and DNA repair Epstein-Barr virus, B cell lymphoproliferative disease, and SCID mice: modeling T cell immunotherapy in vivo Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma Adoptive cellular therapy with T cells specific for EBVderived tumor antigens Standardized and highly efficient expansion of Epstein-Barr virus-specific CD4+ T cells by using virus-like particles The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions The structural basis for serotype-specific neutralization of dengue virus by a human antibody An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex The N276 glycosylation site is required for HIV-1 neutralization by the CD4 binding site specific HJ16 monoclonal antibody Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10 Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience The role of plasma epstein? Given the non-integrative characteristic of the EBV episome and its ability to accommodate large transgene insertion, the use of EBV episomal vector had been extended to genetic studies, protein production, gene therapy, and iPSCs generation. keywords: barr; carcinoma; cells; dna; ebv; epstein; expression; human; nasopharyngeal; npc; protein; therapy; virus cache: cord-275903-sfrpfy5g.txt plain text: cord-275903-sfrpfy5g.txt item: #29 of 53 id: cord-277096-zvb7n9wo author: Bond, David A. title: Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date: 2018-11-29 words: 3712 flesch: 35 summary: The need for routine bleomycin test dosing in the 21st century Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study Chimeric antigen receptormodified T cells in chronic lymphoid leukemia Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab Chimeric antigen receptor-modified T cells for acute lymphoid leukemia Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial Adapted treatment guided by interim PET-CT scan in advanced Hodgkin's lymphoma Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome Expression of the interferoninducible chemokine IP-10 (CXCL10), a chemokine with proposed antineoplastic functions, in Hodgkin lymphoma and nasopharyngeal carcinoma Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates up-regulation of CCL20 and the migration of regulatory T cells Epstein-Barr virus infection induces an increase of T regulatory type 1 cells in Hodgkin lymphoma patients Managing cytokine release syndrome associated with novel T cell-engaging therapies Febrile Hypotensive Reactions Following ABVD e128 -Clinical Lymphoma, Myeloma & Leukemia The febrile, hypotensive syndrome following bleomycin treatment is clinically similar to CRS, a syndrome in which macrophage activating cytokines IL-10 and IL-6 are elevated, and macrophage activation appears to be central to pathogenesis. keywords: abvd; bleomycin; chl; disease; hodgkin; lymphoma; patients; stage; treatment cache: cord-277096-zvb7n9wo.txt plain text: cord-277096-zvb7n9wo.txt item: #30 of 53 id: cord-281086-fmftr5jn author: Morand, A. title: Child with liver transplant recovers from COVID-19 infection. A case report date: 2020-05-06 words: 1183 flesch: 47 summary: key: cord-281086-fmftr5jn authors: Morand, A.; Roquelaure, B.; Colson, P.; Amrane, S.; Bosdure, E.; Raoult, D.; Lagier, J-C; Fabre, A title: Child with liver transplant recovers from COVID-19 infection. The hepatic anicteric cholestasis and cytolysis of our patient was probably due to her transplant state, as no hepatitis during COVID-19 infection was described in the literature [14] . keywords: covid-19; ebv; infection; patients cache: cord-281086-fmftr5jn.txt plain text: cord-281086-fmftr5jn.txt item: #31 of 53 id: cord-281404-5a8au32c author: Gastaldello, Stefano title: Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells date: 2013-10-10 words: 7170 flesch: 36 summary: As illustrated by the representative blots shown in Figure 6A , the anti-HA and anti-FLAG antibodies detected two de-novo expressed enzymatic activities associated with polypeptides of .300 kD and approximately 38 kD in the lysates of induced cells. The specificity of the staining was confirmed by its virtual abrogation in induced cells expressing a BPLF1-specific shRNA. keywords: akata; bplf1; bx1; cand1; caspase-1; cells; cycle; ebv; figure; nedd8; replication; specific; substrates; ubiquitin; virus cache: cord-281404-5a8au32c.txt plain text: cord-281404-5a8au32c.txt item: #32 of 53 id: cord-284235-ae37re3f author: Al-Salam, Suhail title: Prevalence of Epstein–Barr virus in tonsils and adenoids of United Arab Emirates nationals date: 2011-07-12 words: 4059 flesch: 44 summary: However, there is now increasing evidence pointing to B lymphocytes as the likely site of persistent EBV infection, and also as the possible target of primary EBV infection [34] . There is no significant association between EBV infection, age (P = 0.324) and gender (P = 0.442). keywords: adenoids; cells; eber; ebv; infected; infection; lymphocytes; tonsils cache: cord-284235-ae37re3f.txt plain text: cord-284235-ae37re3f.txt item: #33 of 53 id: cord-288945-c9ow1q5c author: Spengler, Ulrich title: Liver Disease Associated with Non-Hepatitis Viruses date: 2019-11-01 words: 7433 flesch: 31 summary: For certain regions simultaneous testing for dengue and Zika virus infection is recommended. Unusual manifestation of infection with Coxsackie virus group B, type 3 Reactivation of human herpesvirus 6 by infection of human herpesvirus 7 Chikungunya fever in travelers: Clinical presentation and course Pathology of fatal human infection associated with avian influenza A H5N1 virus Acyclovir for treatment of infectious mononucleosis: A metaanalysis Valacyclovir for herpes simples virus infection: Long-term safety and sustained efficacy after 20 years' experience with acyclovir Complete clinical and virological remission of refractory HIV-related Kaposi's sarcoma with pegylated interferon alpha Genetic divergence and dispersal of yellow fever virus A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever Quantitation of Epstein-Barr virus mRNA using reverse transcription and real-time PCR Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b Fever in returned travelers: Results from the GeoSentinel surveillance network Temporal pattern of hepatic dysfunction and disease severity in patients with SARS Dengue: Guidelines for diagnosis, treatment, prevention and control World Health Organization (2012) Handbook for clinical management of dengue Recovery from adenovirus pneumonia in a severe combined immunodeficiency patient with intravenous ribavirin Comparison of antiviral compounds against human herpesvirus 6 and 7 Human parvovirus B19 infection associated with acute hepatitis Acute exacerbation of autoimmune liver disease associated with hantaviral infection Human infection by avian influenza A H5N1 Disseminated herpes simplex type 2 and systemic Candida infection in a patient with previous asymptomatic HIV infection Histology slides were kindly provided by Prof. Dr. Hans-Peter Fischer, Department of Pathology, Rheinische Friedrich-Wilhelms University of Bonn, Germany. keywords: acute; cmv; dengue; disease; et al; fever; hepatitis; human; infection; liver; organ; patients; syndrome; transplantation; virus; viruses cache: cord-288945-c9ow1q5c.txt plain text: cord-288945-c9ow1q5c.txt item: #34 of 53 id: cord-289690-af6lsj1g author: Svobodova, Tamara title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 words: 3552 flesch: 37 summary: Chronic lung tissue changes and pulmonary alveolar proteinosis (PAP), as well as pulmonary arterial hypertension, have been described in adult patients [1, [7] [8] [9] . Despite the very low numbers of B cells, normal serum immunoglobulin levels of IgM and IgA and increased levels of IgG were present (23.6 g/l). keywords: cell; changes; deficiency; disease; ebv; gata-2; gata2; infection; lung; patient cache: cord-289690-af6lsj1g.txt plain text: cord-289690-af6lsj1g.txt item: #35 of 53 id: cord-290178-4i0z7ve8 author: Roncati, Luca title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease date: 2020-05-24 words: 386 flesch: 45 summary: EBV belongs to the Herpesviridae family and causes infectious mononucleosis as well as chronic active infections; besides, it can induce various pre-cancerous or cancerous lymphoproliferative disorders, such as mucocutaneous ulcer, Hodgkin lymphoma, Burkitt lymphoma, diffuse large B cell lymphoma, plasmablastic lymphoma, plasma cell myeloma, angioimmunoblastic T cell lymphoma, follicular T cell lymphoma, extranodal NK/T cell lymphoma, and aggressive NK cell leukemia, particularly in immunodeficient and/or post-transplanted patients [3] . key: cord-290178-4i0z7ve8 authors: Roncati, Luca; Lusenti, Beatrice; Nasillo, Vincenzo; Manenti, Antonio title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease date: 2020-05-24 journal: keywords: cell; lymphoma cache: cord-290178-4i0z7ve8.txt plain text: cord-290178-4i0z7ve8.txt item: #36 of 53 id: cord-291063-de7v4e5s author: Moens, Ugo title: Silencing Viral MicroRNA as a Novel Antiviral Therapy? date: 2009-05-28 words: 9133 flesch: 42 summary: Hence, neutralizing the action of viral miRNAs expression by complementary single-stranded oligonucleotides or so-called anti-miRNAs may represent a strategy to combat viral infections and viral-induced pathogenesis. Human polyomaviruses: molecular mechanisms for transformation and their association with cancers The role of polyomaviruses in human disease Identification of a third human polyomavirus Identification of a novel polyomavirus from patients with acute respiratory tract infections Clonal integration of a polyomavirus in human Merkel cell carcinoma Molecular biology of BK virus and clinical aspects of BK virus renal infection SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells Evolutionarily conserved function of a viral microRNA Merkel cell polyomavirus encodes a microRNA with the ability to autoregulate viral gene expression MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs Human cytomegalovirus expresses novel microRNAs during productive viral infection Identification and function of human cytomegalovirus microRNAs Identification of virus-encoded microRNAs A microRNA polycistron as a potential human oncogene Hepadnaviruses HBV-encoded microRNA candidate and its target 25 years of HIV-1 research-progress and perspectives RNA silencing and HIV: a hypothesis for the etiology of the severe combined immunodeficiency induced by the virus HIV-1 nef suppression by virally encoded microRNA Human papillomavirus genotype 31 does not express detectable microRNA levels during latent or productive virus replication Adenoviruses Structure, function and evolution of adenovirus virus-associated RNAs Suppression of RNA interference by adenovirus virus-associated RNA Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production Sequence-specific interference by small RNAs derived from adenovirus VAI RNA The family Herpesviridae: a brief introduction Identification of microRNAs of the herpesvirus family Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor Prediction and identification of herpes simplex virus 1-encoded microRNAs Novel less-abundant viral miRNAs encoded by herpes simplex virus 2 latencyassociated transcript and their roles in regulating ICP34.5 and ICP0 mRNAs keywords: amos; cells; ebv; expression; gene; host; hsv-1; human; infection; k12; micrornas; mir; mirna; protein; replication; silencing; target; virus; viruses cache: cord-291063-de7v4e5s.txt plain text: cord-291063-de7v4e5s.txt item: #37 of 53 id: cord-291295-7og5umiq author: Xin, Shuyu title: Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome date: 2019-12-13 words: 7812 flesch: 49 summary: EBNA1 protein expression was restored in the C2089-shCYPA cells transfected with the wild-type CYPA expression plasmid ( Figure 4B ). EBNA1 protein expression was evaluated by WB after treated or untreated with CsA ( Figure 5C, left) . keywords: assay; binding; cells; cypa; ebna1; ebv; et al; figure; hek293; myc; orip; pcaggs; protein; replication; virus cache: cord-291295-7og5umiq.txt plain text: cord-291295-7og5umiq.txt item: #38 of 53 id: cord-291481-ov1gkgpc author: Bonizzoli, Manuela title: Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date: 2016-05-02 words: 5002 flesch: 40 summary: An independent risk factor for ICU patients with ARDS is an impaired immunophenotype. It has been suggested that the presence of HSV1 in the respiratory samples of ICU patients correlates with the duration of tracheal intubation keywords: ards; dna; herpesviruses; icu; infection; influenza; patients; samples; tract cache: cord-291481-ov1gkgpc.txt plain text: cord-291481-ov1gkgpc.txt item: #39 of 53 id: cord-297222-2danzbqt author: Quadri, Syed P title: An Intriguing Presentation of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis date: 2020-08-05 words: 2096 flesch: 33 summary: Mortality rate remains high despite treatment, ranging from 18-24% in EBV-associated HLH [16] . Acquired HLH is associated with various infections including bacterial, viral, fungal and parasitic; autoimmune diseases including vasculitis, rheumatological disorders, malignancy, and acquired immune deficiency states including AIDS, and with drug use [3, 4] . keywords: diagnosis; ebv; high; hlh; lymphohistiocytosis; treatment cache: cord-297222-2danzbqt.txt plain text: cord-297222-2danzbqt.txt item: #40 of 53 id: cord-304986-lk2ikxda author: Green, Toni M. title: Analogies Between Cancer-Derived Extracellular Vesicles and Enveloped Viruses with an Emphasis on Human Breast Cancer date: 2016-08-27 words: 3694 flesch: 40 summary: The ESCRT pathway Assembly and disassembly of the ESCRT-III membrane scission complex Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag Survivin is released from cancer cells via exosomes The protein interaction network of extracellular vesicles derived from human colorectal cancer cells Lysophosphatidic acid stimulates fas ligand microvesicle release from ovarian cancer cells ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles A36-dependent actin filament nucleation promotes release of vaccinia virus Actin filaments disruption and stabilization affect measles virus maturation by different mechanisms Cooperativity of actin and microtubule elements during replication of respiratory syncytial virus Ceramide recruits and activates protein kinase C f (PKCf) within structured membrane microdomains Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis Regulation of exosome release by glycosphingolipids and flotillins Cholesterol-rich lipid rafts are required for release of infectious human respiratory syncytial virus particles Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferonsensitive virus release through lipid rafts The Trojan exosome hypothesis Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane Extracellular vesicles mediate receptor-independent transmission of novel tick-borne bunyavirus Functional delivery of viral miRNAs via exosomes Exosomal HIF1a supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes Identification of circulating microvesicles' microRNA expression profiles and analysis of functional roles in chronic hepatitis B Exosomemediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA) These miRNAs that are influenced by E6/E7 are also expressed in EVs from breast cancer cells, as mentioned above for miR-21 and miR-378 [100 • ]. keywords: breast; cancer; cells; ebv; evs; exosomes; proteins; release; viruses cache: cord-304986-lk2ikxda.txt plain text: cord-304986-lk2ikxda.txt item: #41 of 53 id: cord-305746-svg3h2oi author: Mentis, A.‐F. A. title: Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation date: 2017-05-23 words: 6310 flesch: 30 summary: HHV-6A infection induces expression of HERV-K18-encoded superantigen Treatment against human endogenous retrovirus: a possible personalized medicine approach for multiple sclerosis Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization Human herpesvirus-6 entry into the central nervous system through the olfactory pathway Possible role of human herpesvirus 6 as a trigger of autoimmune disease Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte Varicella-zoster virus encephalomyelitis with a prominent demyelinating component A population-based casecontrol study on viral infections and vaccinations and subsequent multiple sclerosis risk Association of a history of varicella virus infection with multiple sclerosis Increased risk of multiple sclerosis following herpes zoster: a nationwide, population-based study The high prevalence of the varicella zoster virus in patients with relapsingremitting multiple sclerosis: a case-control study in the north of Iran Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients Varicella-zoster virus at relapses of multiple sclerosis Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis Low prevalence of human herpesvirus-6 and varicella zoster virus in blood of multiple sclerosis patients, irrespective of inflammatory status or disease progression Detection of viral DNA sequences in the cerebrospinal fluid of patients with multiple sclerosis Varicella-zoster virus in cerebrospinal fluid at relapses of multiple sclerosis The participation of varicella zoster virus in relapses of multiple sclerosis Varicella zoster virus in progressive forms of multiple sclerosis The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis On the viral hypothesis of multiple sclerosis: participation of varicella-zoster virus Detection of varicella-zoster virus DNA during medullary and brainstem relapses in multiple sclerosis Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle Multiple sclerosis retrovirus-like envelope gene: role of the chromosome 20 insertion The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease Molecular functions of human endogenous retroviruses in health and disease A survey of endogenous retrovirus (ERV) sequences in the vicinity of multiple sclerosis (MS)-associated single nucleotide polymorphisms (SNPs) The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research EAE is not a useful model for demyelinating disease Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins Infections and multiple sclerosis Aetiology: neighbourhood watch IgG antibodies against measles, rubella, and varicella zoster virus predict conversion to multiple sclerosis in clinically isolated syndrome Virus-mediated autoimmunity in multiple sclerosis Saffold cardiovirus and multiple sclerosis: no evidence for an association Mycovirus-like DNA virus sequences from cattle serum and human brain and serum samples from multiple sclerosis patients Epstein-Barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: yes Epstein-Barr virus is a necessary causative agent in the pathogenesis of multiple sclerosis: no EAE: imperfect but useful models of multiple sclerosis Epstein-Barr virus and multiple sclerosis. keywords: barr; cells; ebv; epstein; herv; human; infection; patients; retrovirus; risk; sclerosis; studies; virus; viruses cache: cord-305746-svg3h2oi.txt plain text: cord-305746-svg3h2oi.txt item: #42 of 53 id: cord-307016-4hdsb5oq author: Allen, Upton title: Prevention and Treatment of Infectious Complications After Solid Organ Transplantation in Children date: 2010-04-30 words: 6747 flesch: 28 summary: The diagnosis of CMV infection and disease in organ transplant recipients can be affected by the variable lack of sensitivity and/or specificity of different diagnostic tests. Valganciclovir dosing according to body surface area and renal function in pediatric solid organ transplant recipients Epstein-Barr virus infections Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: autopsy case report and review of the literature Management of Epstein-Barr virus-induced posttransplant lymphoproliferative disease in recipients of solid organ transplantation New developments in the diagnosis and management of posttransplantation lympholiferative disorders in solid organ transplant recipients Adenoviral infections in pediatric transplant recipients: a hospital-based study Adenovirus infections Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: analysis of 4128 urine and serum samples Quantitative viral load monitoring and cidofovir therapy for the management of BK virus-associated nephropathy in children and adults Varicella Zoster infection in solid organ transplant recipients: a hospital-based retrospective study Varicella zoster virus Sustainability of humoral responses to varicella vaccine in pediatric transplant recipients following a pre-transplantation immunization strategy Varicella-zoster infections Respiratory syncytial virus infections in pediatric liver transplant recipients Parainfluenza and influenza virus infections in pediatric organ transplant recipients keywords: cmv; disease; infection; organ; patients; pediatric; recipients; risk; transplant; transplant recipients; transplantation; treatment; virus cache: cord-307016-4hdsb5oq.txt plain text: cord-307016-4hdsb5oq.txt item: #43 of 53 id: cord-323854-l8gfr19i author: Putz, Austin M title: The effect of a porcine reproductive and respiratory syndrome outbreak on genetic parameters and reaction norms for reproductive performance in pigs date: 2018-12-27 words: 9423 flesch: 48 summary: There is some work needed prior to the swine industry adopting antibody response to PRRS outbreaks or MLV vaccination. The model used was as follows: where the fixed effects vector b included breed, farm, parity, status (prior, during, after), and the fixed covariate of FYW effect estimates for NBA, with corresponding design matrix X. Matrix Q contains coefficients for the random additive genetic effects ( a), which included correlated random intercepts ( a i) and random slopes ( a s) on FYW effect estimates for each individual in the pedigree, connected through the pedigree relationship matrix. keywords: correlations; estimates; et al; farm; fyw; nba; norm; outbreak; prrs; reaction; traits cache: cord-323854-l8gfr19i.txt plain text: cord-323854-l8gfr19i.txt item: #44 of 53 id: cord-327883-s9nbr5y8 author: None title: Section Virology date: 1990-03-31 words: 10597 flesch: 45 summary: Inst. of Virology, Univ., D-6300 Giessen A highly purified nucleoprotein (NP) preparation from influenza virus infected cells yielded in addition to the commonly known 56 kd protein a 42 kd component which could not be detected in virus particles. The biological activity of the clone was confirmed by a variety of criteria: induction of characteristic CPE in susceptible cells infected with cell-free supernatant from cultures transfected with pHSRV; indirect immunofluorescence; radioimmunoprecipitation of viral proteins and electron microscopy. keywords: antibodies; antibody; antigen; binding; cells; dna; ebv; expression; gene; hcmv; hepatitis; hsv; human; infection; patients; positive; protein; region; results; sequences; sera; specific; virus; viruses cache: cord-327883-s9nbr5y8.txt plain text: cord-327883-s9nbr5y8.txt item: #45 of 53 id: cord-328647-0dut550o author: Riachy, M. title: SDRA par pneumonie à EBV date: 2007-05-31 words: 2221 flesch: 46 summary: Chez notre malade d'âge jeune, la pneumonie étendue à EBV était compliquée d'un SDRA sévère ayant nécessité le recours à une ventilation artificielle difficile durant 7 jours. Ils sont utilisés à la dose de 1 mg/kg/j en cas d'obstruction des voies aériennes, d'anémie hémolytique, de thrombopénie sévère et parfois dans les atteintes systémiques du cerveau et du coeur keywords: barr; chez; dans; des; ebv; est; les; une; virus cache: cord-328647-0dut550o.txt plain text: cord-328647-0dut550o.txt item: #46 of 53 id: cord-330698-9t24jo8s author: Wurdinger, Thomas title: Extracellular Vesicles and Their Convergence with Viral Pathways date: 2012-07-25 words: 7459 flesch: 33 summary: Shedding microvesicles: artefacts no more Exosomes: extracellular organelles important in intercellular communication Exosomes-vesicular carriers for intercellular communication Brain tumor microvesicles: insights into intercellular communication in the nervous system The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages Molecular characterization of dendritic cell-derived exosomes: selective accumulation of the heat shock protein hsc73 Membrane vesicles as conveyors of immune responses Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein Ceramide triggers budding of exosome vesicles into multivesicular endosomes Rab27a and Rab27b control different steps of the exosome secretion pathway The regulation of exosome secretion: a novel function of the p53 protein Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences Mechanisms for the formation of membranous nanostructures in cell-to-cell communication ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro Platelet-derived microvesicles transfer tissue factor to monocytes but not to neutrophils Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer Modulation of monocyte-endothelial cell interactions by platelet microparticles Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Functional delivery of viral miRNAs via exosomes Unraveling the mystery of cancer by secretory microRNA: horizontal microRNA transfer between living cells Immune-related microRNAs are abundant in breast milk exosomes Noncytotoxic suppression of human immunodeficiency virus type 1 transcription by exosomes secreted from CD8 + T cells Transfer of the chemokine receptor CCR5 between cells by membranederived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection Plateletand megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathway HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells Genetic characterization of HIV type 1 nef-induced vesicle secretion HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4 + T cells Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation Cytomegalovirusinfected human endothelial cells can stimulate allogeneic CD4 + memory T cells by releasing antigenic exosomes Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells Localization of the Epstein-Barr virus protein LMP 1 to exosomes Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells Interestingly, EBV facilitates these essential interactions for the maturation of B cells, for instance, by upregulation of crucial GC reaction-associated proteins, such as GP183 keywords: cells; ebv; elements; exosomes; hiv; human; immune; infected; infection; membrane; microvesicles; plasma; proteins; release; virus; viruses cache: cord-330698-9t24jo8s.txt plain text: cord-330698-9t24jo8s.txt item: #47 of 53 id: cord-340228-mvqoyror author: Al-Herz, Waleed title: Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry date: 2019-05-29 words: 2932 flesch: 34 summary: While most PIDs predispose to a wide spectrum of viral infections, certain diseases enhance vulnerability to specific viral infections (11) . Front Immunol DOI: 10.3389/fimmu.2019.01231 sha: doc_id: 340228 cord_uid: mvqoyror Objective: To present the frequency and spectrum of viral infections in primary immunodeficient children. keywords: cmv; ebv; immunodeficiencies; infections; kuwait; patients; pid cache: cord-340228-mvqoyror.txt plain text: cord-340228-mvqoyror.txt item: #48 of 53 id: cord-341106-algs6573 author: Min, Hye-Jin title: Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells date: 2009-04-18 words: 3771 flesch: 42 summary: To explore whether the infection of B cells with EBV induces up-regulation of b-catenin, we examined IM9 and Raji B lymphoma cells with a persistent infection of EBV, plus BJAB and Ramos lymphoma cells that are free of EBV. Recent work has shown using B lymphoma cells that infection by Epstein–Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause increases in the expression of β-catenin and cellular transformation. keywords: catenin; cells; hexachlorophene; levels; lmp-1; protein; regulation; siah-1 cache: cord-341106-algs6573.txt plain text: cord-341106-algs6573.txt item: #49 of 53 id: cord-342054-1u2fkwx3 author: Funaro, Ada title: Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells date: 2008-11-12 words: 5486 flesch: 36 summary: Therapeutic antibodies for human diseases at the draw of the twenty-first century Monoclonal antibody successes in the clinic Selecting and screening recombinant antibody libraries Human antibodies from transgenic animals Antibodies for the prevention and treatment of viral diseases Passive antibody therapy for infectious diseases Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza Human monoclonal antibodies by immortalization of memory B cells EB virus-induced B lymphocyte cell lines producing specific antibodies Human monoclonals from antigen-specific selection of B lymphocytes and transformation by EBV Synergy between anti-CD40 MAb and Epstein-Barr virus in activation and transformation of human B lymphocytes An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus The human cytomegalovirus High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effects of primary CMV infection Acceleration of allograft failure by cytomegalovirus Human antibodies for immunotherapy development generated via a human B cell hybridoma technology Potent antibody therapeutics by design Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2 Immunotherapeutic uses of CpG oligodeoxynucleotides Phosphorothioatemodified oligodeoxynucleotides inhibit human cytomegalovirus replication by blocking virus entry Innate apoptosis of human B lymphoblasts transformed by Epstein-Barr virus: modulation by cellular immortalization and senescence Epstein-Barr virus provides a new paradigm: a requirement for the immediate inhibition of apoptosis Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus CpG motifs in bacterial DNA trigger direct B-cell activation Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo Activation of human B cells by phosphorothioate oligodeoxynucleotides Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide Immune activation suppresses initiation of lytic Epstein-Barr virus infection The tolllike receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells Mechanism and function of a newly identified CpG DNA motif in human primary B cells Determination of the role for CD21 during Epstein-Barr virus infection of B-lymphoblastoid cells Epstein-Barr virus-induced B-cell transformation: quantitating events from virus binding to cell outgrowth B cell activation and the establishment of Epstein-Barr virus latency Cell surface phenotyping and cytokine production of Epstein-Barr Virus (EBV)-transformed lymphoblastoid cell lines (LCLs) It has been reported that TLR-9 triggering resulted in higher transformation rates of B cells infected with EBV [12] but a comparison between EBV transformation in the presence of CpG2006 and EBV and after sequential exposure of B cells to CpG2006 and separately to EBV, was not investigated. keywords: activity; antibodies; cells; cpg2006; ebv; hcmv; human; igg; infection; lymphocytes; mab; mabs; virus cache: cord-342054-1u2fkwx3.txt plain text: cord-342054-1u2fkwx3.txt item: #50 of 53 id: cord-345922-3waid65i author: Tiwari, Sneham title: Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis date: 2018-09-11 words: 7808 flesch: 24 summary: Results and Problems in Cell Differentiation Encephalomyelitis in the rat following intracutaneous injection of central nervous system tissue with adjuvant Pathological consequences of systemic measles virus infection Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis Epstein-barr virus: Environmental trigger of multiple sclerosis Smoking induces DNA methylation changes in multiple sclerosis patients with exposure-response relationship Updates on clinically isolated syndrome and diagnostic criteria for multiple sclerosis Intra-axonal virus in demyelinative lesions of experimental herpes simplex type 2 infection The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system The MHC locus and genetic susceptibility to autoimmune and infectious diseases B cell treatments for multiple sclerosis Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: Concerted action guidelines Clinically isolated syndromes suggestive of multiple sclerosis, part 2: Non-conventional MRI, recovery processes, and management High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effect Multiple sclerosis: Geoepidemiology, genetics and the environment The gut microbiome and microbial translocation in multiple sclerosis Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation Human coronavirus OC43 associated with fatal encephalitis Elicitation of experimental allergic encephalomyelitis (EAE) in mice with the aid of pertussigen Monoclonal antibodies in the treatment of multiple sclerosis: Emergence of B-cell-targeted therapies Multiple sclerosis after infectious mononucleosis Interferon beta augments suppressor cell function in multiple sclerosis Measles virus antibodies in multiple sclerosis. in patients with multiple sclerosis experiencing breakthrough disease: A randomized, raterblinded trial A single-nucleotide polymorphism in serine-threonine kinase 11, the gene encoding liver kinase B1, is a risk factor for multiple sclerosis Effects of long-term resistance training and simultaneous electro-stimulation on muscle strength and functional mobility in multiple sclerosis Exocytosis of varicella-zoster virus virions involves a convergence of endosomal and autophagy pathways Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: A phase I/II study The curious case of clioquinol Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis Role of tumour necrosis factor (TNF)-alpha and TNFRSF1A R92Q mutation in the pathogenesis of TNF receptor-associated periodic syndrome and multiple sclerosis Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells Remyelination in multiple sclerosis European/Canadian multicenter, double-blind, randomized, placebo-controlled study of the effects of glatiramer acetate on magnetic resonance imaging-measured disease activity and burden in patients with relapsing multiple sclerosis Multiple sclerosis Multiple sclerosis Progressive multiple sclerosis: From pathogenic mechanisms to treatment Association of Mycobacterium avium subsp. keywords: activation; antigen; autoimmune; cells; demyelination; disease; ebv; encephalomyelitis; et al; factors; infection; mechanisms; model; myelin; pathogenesis; patients; risk; sclerosis; system; virus cache: cord-345922-3waid65i.txt plain text: cord-345922-3waid65i.txt item: #51 of 53 id: cord-348388-nkosag8m author: Nirenberg, Michael S. title: Foot manifestations in a patient with COVID-19 and Epstein-Barr virus: A case study date: 2020-06-22 words: 1678 flesch: 55 summary: Also, since numerous diseases are known to cause cutaneous manifestations, including some that can affect the feet [21, 22] , it is not known if skin issues observed in COVID-19 patients are due to COVID-19 or the result of a co-infection, perhaps unrecognized. Available at SSRN 3555268 Child with liver transplant recovers from COVID-19 infection. keywords: case; covid-19; foot; manifestations; patient cache: cord-348388-nkosag8m.txt plain text: cord-348388-nkosag8m.txt item: #52 of 53 id: cord-350807-qdq96723 author: Reckziegel, Maria title: Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection date: 2020-05-27 words: 4659 flesch: 37 summary: Seminars in respiratory and critical care medicine Respiratory syncytial virus: infection, detection, and new options for prevention and treatment Human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation Laboratory diagnosis of infections in cancer patients: challenges and opportunities Impact of viral multiplex real-time PCR on management of respiratory tract infection: a retrospective cohort study Burden of human metapneumovirus infections in patients with cancer: risk factors and outcomes Infection in organ transplantation Antiviral therapy for respiratory viral infections in immunocompromised patients Respiratory viral infections in solid organ and hematopoietic stem cell transplantation Treatment of alpha and beta herpesvirus infections in solid organ transplant recipients Herpesvirus respiratory infections in immunocompromised patients: epidemiology, management, and outcomes Multiple viral infections after haploidentical hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia Virus-bacteria interactions: an emerging topic in human infection Viral-bacterial co-infections in the respiratory tract Bacterial pneumonia as an influenza complication An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome Metagenomic sequencing detects respiratory pathogens in hematopoietic cellular transplant patients Effective use of oral ribavirin for respiratory syncytial viral infections in allogeneic haematopoietic stem cell transplant recipients Consecutive yearly outbreaks of respiratory syncytial virus in a haemato-oncology ward and efficacy of infection control measures Parainfluenza 3 infections early after kidney or simultaneous pancreas-kidney transplantation In vivo persistence of human rhinoviruses in immunosuppressed patients The Virome of the human respiratory tract Generation of multipotent cell lines from a distinct population of male germ line stem cells Lack of p73 mutations and late occurrence of p73 allelic deletions in melanoma tissues and cell lines Establishment of PCR for the early diagnosis of herpes simplex encephalitis HSV-2 DNA persistence in astrocytes of the trigeminal root entry zone: double labeling by in situ PCR and immunohistochemistry Detection of varicella-zoster virus DNA by polymerase chain reaction in the cerebrospinal fluid of patients suffering from neurological complications associated with chicken pox or herpes zoster Evaluation of the polymerase chain reaction for diagnosis of herpes simplex virus encephalitis Monitoring of patients for cytomegalovirus after organ transplantation by centrifugation culture and PCR Laboratory diagnosis of herpes zoster Detection of herpes simplex virus (types 1 and 2) and human herpesvirus 6 DNA in human brain tissue by polymerase chain reaction Detection by PCR of HHV-6 and EBV DNA in blood and oropharynx of healthy adults and HIV-seropositives Comparison of a LightCyclerbased real-time PCR for quantitation of Epstein-Barr viral load in different clinical specimens with semiquantitative PCR Human parechovirus infections in Dutch children and the association between serotype and disease severity Prevalence, types, and RNA concentrations of human parechoviruses, including a sixth parechovirus type, in stool samples from patients with acute enteritis Screening respiratory samples for detection of human rhinoviruses (HRVs) and enteroviruses: comprehensive VP4-VP2 typing reveals high incidence and genetic diversity of HRV species C MEGA6: molecular evolutionary genetics analysis version 6.0 Viruses as sole causative agents of severe acute respiratory tract infections in children Seroprevalence of herpes simplex virus type 1 and type 2 in Thuringia Seroprevalence of varicella-zoster virus in the German population Evolution of EBV seroprevalence and primary infection age in a French hospital and a city laboratory network Cytomegalovirus seroprevalence among children and adolescents in Germany: data from the German health interview and examination survey for children and adolescents (KiGGS) Human herpesvirus 6 Herpesvirus infections in organ transplant recipients Clinical impact of HSV-1 detection in the lower respiratory tract from hospitalized adult patients Quantitative detection of Epstein-Barr virus in bronchoalveolar lavage from transplant and nontransplant patients Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract? Epstein-Barr virus-associated pneumonia in patients with posttransplant lymphoproliferative disease after hematopoietic stem cell transplantation The role of infection in interstitial lung diseases: a review Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient Detection of Epstein-Barr virus DNA in peripheral blood is associated with the development of bronchiolitis obliterans syndrome after lung transplantation Chromosomally integrated human herpesvirus 6: questions and answers Human herpesvirus-6 infections in kidney, liver, lung, and heart transplantation: review Varicella pneumonia in adults Detection of respiratory viruses using a multiplex real-time PCR assay in Germany Respiratory syncytial virus infection-associated hospitalization in adults: a retrospective cohort study Human bocaviruses: possible etiologic role in respiratory infection Human bocavirus infection as a cause of severe acute respiratory tract infection in children Frequent detection of bocavirus DNA in German children with respiratory tract infections Current understanding of human enterovirus D68 Enterovirus and parechovirus infection in children: a brief overview A method to identify respiratory virus infections in clinical samples using next-generation sequencing Capnetz Study G (2015) keywords: cmv; detection; dna; ebv; infections; patients; pcr; samples; study; tract; viruses cache: cord-350807-qdq96723.txt plain text: cord-350807-qdq96723.txt item: #53 of 53 id: cord-356062-7q5n4t97 author: None title: Cumulative pharmacological activity index volumes 1-30 date: 2005-12-31 words: 6484 flesch: -24 summary: 29:99 activity in EBV assay system 29:99 11, 15, activity in EBV assay system 29:99 Abieta-8,11,13-triene-7o~,l Human melanoma 23:255 Human mesangial cell proliferation 30:308 in vitro Human monoblastic leukemia cells 30:498 effect of hydroxyurea (HU) 30:498 growth inhibition of 30:498 Human monoblastic leukemia U937 cells 30:498 growth inhibition of Human neuroblastoma nbla-N-5 cells tamoxifen activity against 12:390 Human neuroblastoma SH-SY-5Y cells 12:390 Human neutrophils 12:390 Human neutropil protein kinase C 12:389 Human onchocerciasis 12:9 ivermectin for Human papilloma virus 30:394 pathogenesis of 30:394 cause of hepatocellular carcinoma Human Papilloma virus (HPV) 23:97 Human papilloma virus type 11 30:406 microbicidal compound against Human papilloma virus type 40 30:406 microbicidal compound against 30:406 Human platelets 12:390 study of protein kinase C in 12:390 by staurosporine 12:390 Human rotavirus (HRV) 30:406,412 cause of dehydrating gastroenteritis 30:406 member of 30:406 reoviridae type of Human serotonin transporter gene (SLC6A4) 30:376 regulation of neuronal activity Human spermatozoa motility 21:675 Human synovial PLA2 25:697 inhibitor anti-glycemic effects 24:902-904 anti-hyperglycemic effects of -O-methyl-20-hydroxyecdysone activity in 29:28 pinnatasterone activity in 29:28 polypodine B 2-O-cinnamate activity in Muscarinic AchR antagonists 21:56 Muscarinic antagonist 22:19 Muscarinic receptor 21:95 Muscarinic receptor antagonists 22:734 Muscarinic-l,2-receptor 21:95 Muscle pain 24:898 aconitine for relieving activation effects of 24:906 medicinal uses of 24:906 protein kinase C activation effects 24:906 Muscular P-388 (murine lymphocytic leukemia) 30:588 activity of (-)-deoxypodophyllotoxin against 30:588 activity of (-)-yatein against P-388 lymphocytic leukemia cell 25:764 keywords: 29:720; 30:589; 30:815; acid; activity; agent; antitumor; assay system; bioassay; cell; ebv; effects; human; inhibitor; kinase; nh2; properties; protease; protein; receptor; role; type; tyr; use; virus cache: cord-356062-7q5n4t97.txt plain text: cord-356062-7q5n4t97.txt