# bib

id: cord-309141-vwudbuzz
author: Barbiero, Victor K.
title: Ebola: A Hyperinflated Emergency
date: 2020-06-30
extension: .txt
mime: text/plain
words: 1278
sentence: 66
flesch: 53
cache: cache/cord-309141-vwudbuzz.txt
txt: txt/cord-309141-vwudbuzz.txt
summary:
  The term public health emergency of international concern (PHEIC) is defined in the International Health Regulations (2005) as: An extraordinary event, which is determined, as provided in these Regulations: to constitute a public health risk to other States through the international spread of disease; and to potentially require a coordinated international response. UNICEF Global Databases IHR Procedures concerning public health emergencies of international concern (PHEIC)


id: cord-255040-xzs7d497
author: Lau, Joseph T.F.
title: Anticipated Negative Responses by Students to Possible Ebola Virus Outbreak, Guangzhou, China
date: 2016-01-17
extension: .txt
mime: text/plain
words: 1475
sentence: 52
flesch: 36
cache: cache/cord-255040-xzs7d497.txt
txt: txt/cord-255040-xzs7d497.txt
summary:
  About half of respondents believed that effective treatment and a vaccine were unavailable (51.9% and 59.1%, respectively); 22.2% anticipated EVD outbreaks among Africans in Guangzhou (during the next 12 months). We constructed scales for the dependent and independent variables to assess EVD-related perceptions: 1) misconceptions/knowledge about transmission modes, 2) scenarios of an EVD outbreak in Guangzhou (chances, severity, control), 3) efficacy of preventive measures and self-protection, and 4) public stigma toward EVD survivors.


id: cord-001611-9xgmanai
author: Matlock, Ann Marie
date: 2015-01-01
extension: .txt
mime: text/plain
words: 2277
sentence: 82
flesch: 46
cache: cache/cord-001611-9xgmanai.txt
txt: txt/cord-001611-9xgmanai.txt
title:
  Providing nursing care to Ebola patients on the national stage: The National Institutes of Health experience

summary:
  Nurses who expressed an interest in volunteering to provide direct patient care were educated about Ebola, trained in SCSU procedures, and oriented. key: cord-001611-9xgmanai authors: Matlock, Ann Marie; Gutierrez, Debbie; Wallen, Gwenyth; Hastings, Clare title: Providing nursing care to Ebola patients on the national stage: The National Institutes of Health experience date: 2015-01-01 journal: Nursing Outlook DOI: 10.1016/j.outlook.2014.11.015 sha: doc_id: 1611 cord_uid: 9xgmanai nan Plans had been underway since July to prepare for the admission of a patient with EVD, or exposure, to the NIH Clinical Center.


id: cord-280164-dukccrjb
author: Nachega, Jean B.
date: 2020-06-19
extension: .txt
mime: text/plain
words: 2310
sentence: 88
flesch: 45
cache: cache/cord-280164-dukccrjb.txt
txt: txt/cord-280164-dukccrjb.txt
title:
  Responding to the Challenge of the Dual COVID-19 and Ebola Epidemics in the Democratic Republic of Congo—Priorities for Achieving Control

summary:
  Third, the follow-up of COVID-19 contacts is modeled after our EVD experience using contact-tracers and community health workers (CHCWs) at the peripheral level: health areas, neighborhoods, and villages. 14 Serological testing for antiviral antibodies is unavailable in the DRC and is unsuitable for diagnosing active COVID-19 cases.


id: cord-266415-8w5elfro
author: Tambo, Ernest
date: 2014-08-05
extension: .txt
mime: text/plain
words: 2999
sentence: 91
flesch: 28
cache: cache/cord-266415-8w5elfro.txt
txt: txt/cord-266415-8w5elfro.txt
title:
  Need of surveillance response systems to combat Ebola outbreaks and other emerging infectious diseases in African countries

summary:
  For the purposes of this paper, five have been identified: (i) the deficiency in the development and implementation of surveillance response systems against Ebola and others infectious disease outbreaks in Africa; (ii) the lack of education and knowledge resulting in an EVD outbreak triggering panic, anxiety, psychosocial trauma, isolation and dignity impounding, stigmatisation, community ostracism and resistance to associated socio-ecological and public health consequences; (iii) limited financial resources, human technical capacity and weak community and national health system operational plans for prevention and control responses, practices and management; (iv) inadequate leadership and coordination; and (v) the lack of development of new strategies, tools and approaches, such as improved diagnostics and novel therapies including vaccines which can assist in preventing, controlling and containing Ebola outbreaks as well as the spread of the disease. Therefore, the following actions are recommended: (i) national and regional inter-sectorial and trans-disciplinary surveillance response systems that include early warnings, as well as critical human resources development, must be quickly adopted by allied ministries and organisations in African countries in epidemic and pandemic responses; (ii) harnessing all stakeholders commitment and advocacy in sustained funding, collaboration, communication and networking including community participation to enhance a coordinated responses, as well as tracking and prompt case management to combat challenges; (iii) more research and development in new drug discovery and vaccines; and (iv) understanding the involvement of global health to promote the establishment of public health surveillance response systems with functions of early warning, as well as monitoring and evaluation in upholding research-action programmes and innovative interventions.


id: cord-290637-3tgtstd4
author: Ferranti, Erin P.
date: 2016-12-31
extension: .txt
mime: text/plain
words: 3773
sentence: 153
flesch: 51
cache: cache/cord-290637-3tgtstd4.txt
txt: txt/cord-290637-3tgtstd4.txt
title:
  Implementation of an educational program for nursing students amidst the Ebola virus disease epidemic

summary:
  Additional goals for providing education were to increase student knowledge of EVD risks and ways to mitigate exposure, decrease fear of EVD, and enhance students' confidence in discussing EVD with others, including family, friends, and patients. Discussion Implementation of a JiTT educational program effectively achieved our goals to increase EVD knowledge, decrease fear, and enhance student confidence in the ability to discuss EVD risk.


id: cord-260779-riw5xs3j
author: van Griensven, Johan
date: 2016-01-01
extension: .txt
mime: text/plain
words: 3826
sentence: 167
flesch: 43
cache: cache/cord-260779-riw5xs3j.txt
txt: txt/cord-260779-riw5xs3j.txt
title:
  The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource-Constrained Settings: A Perspective From the Field

summary:
  Compassionate use of experimental treatments for Ebola virus disease: outcomes in 14 patients admitted from Ebola virus convalescent blood products: where we are now and where we may need to go Minipool caprylic acid fractionation of plasma using disposable equipment: a practical method to enhance immunoglobulin supply in developing countries Emergency evaluation of convalescent plasma for Ebola viral disease (EVD) in Guinea Clinical trial to evaluate the efficacy and safety of convalescent plasma for Ebola treatment (EVD001). Longer followup of CP treated patients is also indicated to detect late adverse events.


id: cord-003127-1t0mklwi
author: Wendelboe, Aaron M.
date: 2018-07-27
extension: .txt
mime: text/plain
words: 4107
sentence: 204
flesch: 53
cache: cache/cord-003127-1t0mklwi.txt
txt: txt/cord-003127-1t0mklwi.txt
title:
  Managing emerging transnational public health security threats: lessons learned from the 2014 West African Ebola outbreak

summary:
  The response by the US arguably began in March 2014 when CDC deployed personnel to investigate Ebola cases in Guinea, and further on July 9, 2014 with the activation of CDC's Emergency Operations Center. After Ebola in West Africa--unpredictable risks, preventable epidemics Estimating the future number of cases in the Ebola epidemic--Liberia and Sierra Leone One Year into the Ebola Epidemic: a Deadly Accessed 8 Investigating the zoonotic origin of the west African Ebola epidemic Bat-filled tree may have been ground zero for the Ebola epidemic Ebola virus disease--Sierra Leone and Guinea CDC classification of countries with reported Ebola cases for evaluation of persons in the United States Accessed 8 Ebola Situation Report WHO Strategic Action Plan for Ebola Outbreak Response: Annex 1 Accessed 8 Accessed 8 WHO: Ebola Response Roadmap Update Cases of Ebola Diagnosed in the United States Accessed 22 How many Ebola patients have been treated outside of Africa Accessed 15 Ebola Virus Disease -United Kingdom Accessed 22 Ebola Situation Report -22 Accessed 8 World Health Organization.


id: cord-260037-ys62jrgw
author: Jecker, Nancy S.
title: Ebola Virus Disease Ethics and Emergency Medical Response Policy
date: 2015-09-30
extension: .txt
mime: text/plain
words: 4562
sentence: 176
flesch: 44
cache: cache/cord-260037-ys62jrgw.txt
txt: txt/cord-260037-ys62jrgw.txt
summary:
  Th e fragile web of responsibility: AIDS and the duty to treat The problem with rescue medicine Wrong Medicine: Doctors, Patients, and Futile Treatment Beyond futility to an ethic of care Ethical guidance on the use of life-sustaining therapies for patients with Ebola in developed countries Guidance paper: Ebola Treatment Centre (ETC): pregnant and lactating women Practice advisory: care of obstetric patients during an Ebola virus outbreak . Time Magazine Panic, paranoia, and public health-the AIDS epidemic's lessons for Ebola Doing today's work superbly well-treating Ebola with current tools Triage in medicine, part II: underlying values and principles Overwhelming casualties: medical ethics in a time of terror Triage: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement Ethical considerations: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement Ethical resource distribution aft er biological, chemical, or radiological terrorism Recognition of illness associated with the intentional release of a biologic agent Smallpox disease overview Randomised controlled trials for Ebola: practical and ethical issues Guidance for safe handling of human remains of Ebola patients by hospital and mortuaries Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential confl icts of interest exist with any companies/ organizations whose products or services may be discussed in this article .


id: cord-003507-22ylifqo
author: Kelly, J. Daniel
date: 2019-03-07
extension: .txt
mime: text/plain
words: 4483
sentence: 163
flesch: 44
cache: cache/cord-003507-22ylifqo.txt
txt: txt/cord-003507-22ylifqo.txt
title:
  Projections of Ebola outbreak size and duration with and without vaccine use in Équateur, Democratic Republic of Congo, as of May 27, 2018

summary:
  List of 21 prior Ebola outbreaks from 1976 to 2016 by time period, country, confirmed/probable reported and time series case count, outbreak inclusion into the regression and stochastic models. We modeled Ebola virus transmission using a stochastic branching process model that included reproduction numbers from past Ebola outbreaks and a particle filtering method to generate a probabilistic projection of the outbreak size and duration conditioned on its reported trajectory to date; modeled using high (62%), low (44%), and zero (0%) estimates of vaccination coverage (after deployment).


id: cord-016177-fz48wydz
author: Bezek, Sarah
title: Emergency Triage of Highly Infectious Diseases and Bioterrorism
date: 2020-01-03
extension: .txt
mime: text/plain
words: 4382
sentence: 155
flesch: 30
cache: cache/cord-016177-fz48wydz.txt
txt: txt/cord-016177-fz48wydz.txt
summary:
  Disease control policies and programs can strengthen infectious disease and bioterrorist attack care and surveillance at each of these levels. An emergency department response to severe acute respiratory syndrome: a prototype response to bioterrorism Outside the box and into thick air: implementation of an exterior mobile pediatric emergency response team for North American H1N1 (swine) influenza virus in Development and use of mobile containment units for the evaluation and treatment of potential Ebola virus disease patients in a United States Hospital The current state of bioterrorist attack surveillance and preparedness in the US Hospital triage system for adult patients using an influenzalike illness scoring system during the 2009 pandemic-Mexico The simple triage scoring system (STSS) successfully predicts mortality and critical care resource utilization in H1N1 pandemic flu: a retrospective analysis Triage care of the critically ill and Injured during pandemics and disasters: CHEST consensus statement Surge capacity of hospitals in emergencies and disasters with a preparedness approach: a systematic review Regional treatment network for Ebola and other special pathogens S. airport entry screening in response to pandemic influenza: modeling and analysis Enhanced Ebola screening to start at five U.S. airports for all people entering U.S. from Ebola-affected countries Responding to communicable diseases in internationally mobile populations at points of entry and along porous borders A systematic review of emerging respiratory viruses at the Hajj and possible coinfection with Streptococcus pneumoniae Natural disasters, armed conflict, and public health The sphere handbook: humanitarian charter and minimum standards in humanitarian response Bioterrorism readiness plan: a template for healthcare facilities Augmentation of hospital critical care capacity after bioterrorist attacks or epidemics: recommendations of the Working Group on Emergency Mass Critical Care AAP Disaster Preparedness Advisory Council.


id: cord-257504-tqzvdssb
author: Dubost, Clément
date: 2015-11-24
extension: .txt
mime: text/plain
words: 5150
sentence: 255
flesch: 54
cache: cache/cord-257504-tqzvdssb.txt
txt: txt/cord-257504-tqzvdssb.txt
title:
  Preparation of an intensive care unit in France for the reception of a confirmed case of Ebola virus infection()

summary:
  It is now clear that northern countries will be implicated in the care of EVD patients, both in the field and back at home. It is now clear that northern countries will be implicated in the care of EVD patients, both in the field and back at home.


id: cord-004269-g6ki6vyy
author: de Rooij, Doret
title: Qualitative Research: Institutional Preparedness During Threats of Infectious Disease Outbreaks
date: 2020-01-23
extension: .txt
mime: text/plain
words: 5498
sentence: 276
flesch: 41
cache: cache/cord-004269-g6ki6vyy.txt
txt: txt/cord-004269-g6ki6vyy.txt
summary:
  Per preparedness phase, the participant was asked if and why preparedness activities would be necessary for their healthcare institution. (iii) For ambulance services, preparedness activities start in preparedness phase orange and no clear difference in preparedness activities were identified between preparedness phase orange and preparedness phase red.


id: cord-012040-24112w2j
author: Hung, Yuen W
date: 2020-07-27
extension: .txt
mime: text/plain
words: 5700
sentence: 232
flesch: 53
cache: cache/cord-012040-24112w2j.txt
txt: txt/cord-012040-24112w2j.txt
title:
  Impact of a free care policy on the utilisation of health services during an Ebola outbreak in the Democratic Republic of Congo: an interrupted time-series analysis

summary:
  overall Relative to control health zones, rates of total clinic visits increased substantially in FCP health zones following the start of the EVD outbreak and we see similar increases in both the EVD and FCP health zones and the FCP-only health zones. key: cord-012040-24112w2j authors: Hung, Yuen W; Law, Michael R; Cheng, Lucy; Abramowitz, Sharon; Alcayna-Stevens, Lys; Lurton, Grégoire; Mayaka, Serge Manitu; Olekhnovitch, Romain; Kyomba, Gabriel; Ruton, Hinda; Ramazani, Sylvain Yuma; Grépin, Karen A title: Impact of a free care policy on the utilisation of health services during an Ebola outbreak in the Democratic Republic of Congo: an interrupted time-series analysis date: 2020-07-27 journal: BMJ Glob Health DOI: 10.1136/bmjgh-2019-002119 sha: doc_id: 12040 cord_uid: 24112w2j BACKGROUND: During past outbreaks of Ebola virus disease (EVD) and other infectious diseases, health service utilisation declined among the general public, delaying health seeking behaviour and affecting population health.


id: cord-018780-zeok60hn
author: Biddinger, Paul D.
title: Evaluation of the Person Under Investigation
date: 2018-07-07
extension: .txt
mime: text/plain
words: 5766
sentence: 191
flesch: 39
cache: cache/cord-018780-zeok60hn.txt
txt: txt/cord-018780-zeok60hn.txt
summary:
  In addition, depending upon the need to reduce risks to other patients and HCWs, regular laboratory and imaging equipment may not be available (or available at the standard frequency or turnaround time) to support medical care. The ability to detect and diagnose patients infected with a highly hazardous communicable disease (HHCD) must be a priority for healthcare facilities in order to limit the morbidity and mortality of infection and to ensure the safety of staff and other patients through the early initiation of appropriate infection prevention measures.


id: cord-003917-bswndfvk
author: Lalle, Eleonora
title: Pulmonary Involvement during the Ebola Virus Disease
date: 2019-08-24
extension: .txt
mime: text/plain
words: 5546
sentence: 181
flesch: 31
cache: cache/cord-003917-bswndfvk.txt
txt: txt/cord-003917-bswndfvk.txt
summary:
  A case report Antibody prevalence against haemorrhagic fever viruses in randomized representative Central African populations Risk factors for patients without a reported exposure CDC Centers for Disease Control and Prevention Guidance for Donning and Doffing Personal Protective Equipment (PPE) During Management of Patients with Ebola Virus Disease Interim Infection Prevention and Control Guidance for Care of Patients with Suspected or Confirmed Filovirus Haemorrhagic Fever in Health-Care Settings, with Focus on Ebola Nucleic acid amplification-based diagnosis of respiratory virus infections Understanding Ebola virus transmission Ebola and Marburg virus antibody prevalence in selected populations of the Central African Republic The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly Respiratory syncytial virus infection in adults Respiratory syncytial virus Measles virus: Cellular receptors, tropism and pathogenesis Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine-origin influenza type A/H1N1 and acute respiratory failure Pathogenesis of severe acute respiratory syndrome Pathogenesis of the viral hemorrhagic fevers Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES Pathogenesis of Lassa Fever. Soldier in the Fight against Respiratory Viruses Epithelial antimicrobial peptides and proteins: Their role in host defence and inflammation Centers for Disease Control and Prevention (CDC) CDC Grand Rounds: Discovering new diseases via enhanced partnership between public health and pathology experts Detection of Viral RNA in Tissues following Plasma Clearance from an Ebola Virus Infected Patient Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily Infection and activation of monocytes by Marburg and Ebola viruses Kinetics of Soluble Mediators of the Host Response in Ebola Virus Disease Human Ebola virus infection results in substantial immune activation Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014-2016 Outbreak in West Africa Into the Eye of the Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis Dendritic cells and the control of immunity The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation Immune barriers of Ebola virus infection Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections Ebola haemorrhagic fever virus:


id: cord-298796-ajzfnd7g
author: Herstein, Jocelyn J.
title: Sustainability of High-Level Isolation Capabilities among US Ebola Treatment Centers
date: 2017-06-17
extension: .txt
mime: text/plain
words: 1620
sentence: 57
flesch: 38
cache: cache/cord-298796-ajzfnd7g.txt
txt: txt/cord-298796-ajzfnd7g.txt
summary:
  A 2015 pilot survey of US HLIUs described the actions taken to establish high-level isolation capabilities and identified the costs of those efforts (4-6). Thus, more than half of US HLIUs that routinely care for non-HID patients would build an HID-dedicated unit if funds were available.


id: cord-306972-alyyju5x
author: James, Peter Bai
date: 2020-02-05
extension: .txt
mime: text/plain
words: 5891
sentence: 222
flesch: 44
cache: cache/cord-306972-alyyju5x.txt
txt: txt/cord-306972-alyyju5x.txt
title:
  An assessment of Ebola-related stigma and its association with informal healthcare utilisation among Ebola survivors in Sierra Leone: a cross-sectional study

summary:
  We randomly sampled the required number of EVD survivors in all five districts based on proportional representation using the national list of registered Ebola survivors obtained from the Sierra Leone Association of Ebola survivors (SLAES). [43] to measure EVD related stigma among EVD survivors, as there is no detailed or validated tool exist for EVD related stigma.


id: cord-016946-p883xjq5
author: Bindenagel Šehović, Annamarie
title: Introducing Ebola (EVD): An Unnecessary Surprise
date: 2017-05-09
extension: .txt
mime: text/plain
words: 4679
sentence: 227
flesch: 52
cache: cache/cord-016946-p883xjq5.txt
txt: txt/cord-016946-p883xjq5.txt
summary:
  18 Resolution 2177 (2014) placed the onus for Ebola response on the national state. 10 One advantage of Ebola infection is that those who have become ill, and infectious, are visibly sick.


id: cord-258504-pnd46ipd
author: Bleasdale, Susan C.
title: Experience of Chicagoland acute care hospitals in preparing for Ebola virus disease, 2014–2015
date: 2019-07-08
extension: .txt
mime: text/plain
words: 6056
sentence: 223
flesch: 38
cache: cache/cord-258504-pnd46ipd.txt
txt: txt/cord-258504-pnd46ipd.txt
summary:
  Despite these identified gaps, interviewed trainers from only two hospitals indicated a change in routine training, specifically, new employee orientation was changed to include hands-on training in PPE donning/doffing. Hospitals in the Chicagoland area were resourceful in their occupational health preparations for the 2014-2015 EVD outbreak were able to select PPE ensembles they judged appropriate for the hospital's role in the regional EVD plan and trained HCP in the use of enhanced PPE ensembles and/or EVD patient care. More specifically, questions included: 1) how PPE ensembles were selected, 2) considerations for PPE acquisition and use, and 3) how training in the use of PPE ensembles and EVD patient care was developed and delivered.


id: cord-004069-nuep8nim
author: DeWald, Lisa Evans
title: In Vivo Activity of Amodiaquine against Ebola Virus Infection
date: 2019-12-27
extension: .txt
mime: text/plain
words: 5724
sentence: 218
flesch: 47
cache: cache/cord-004069-nuep8nim.txt
txt: txt/cord-004069-nuep8nim.txt
summary:
  Whereas AQ treatment did not lead to detectable beneficial effects on EVD progression in NHPs, there may be value in investigating novel AQ derivatives that have been improved for anti-EBOV potency and/or improved tolerability 22 . A possible impact from AQ side effects needs to be considered.


id: cord-001827-vqoxd64i
author: Rosello, Alicia
title: Ebola virus disease in the Democratic Republic of the Congo, 1976-2014
date: 2015-11-03
extension: .txt
mime: text/plain
words: 6694
sentence: 272
flesch: 55
cache: cache/cord-001827-vqoxd64i.txt
txt: txt/cord-001827-vqoxd64i.txt
summary:
  determinants of survival A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures Ebola haemorrhagic fever in Zaire Case definition recommendations for Ebola or Marburg virus diseases This study was funded by the Fischer Family Trust, the National Institute for Health Research Health Protection Research Unit in Immunisation at the London School of Hygiene and Tropical Medicine in partnership with Public Health England, the Research for Health in Humanitarian Crises Programme (managed by Research for Humanitarian Assistance, Grant 13165). Here, for the first time, all the databases from EVD outbreaks in the Democratic Republic of the Congo (DRC) have been cleaned and compiled into one anonymised individual-level dataset (See Supplementary file 1).


id: cord-329726-4494x6ii
author: Gabel Speroni, Karen
title: Call to Action for a US Nurse General: From Ebola to Corona
date: 2020-04-21
extension: .txt
mime: text/plain
words: 547
sentence: 25
flesch: 58
cache: cache/cord-329726-4494x6ii.txt
txt: txt/cord-329726-4494x6ii.txt
summary:
  2, 3 Researchers reported concerns of RNs, who identified not only EVD challenges but also those that are applicable to new emerging diseases. Nurses statements from the EVD study continue to be on point for COVID-19, including We need a new practice specialty of nursing for emerging diseases and biohazard, etc.


id: cord-004639-qwxkn0j0
author: Aceng, Jane Ruth
title: Uganda’s experience in Ebola virus disease outbreak preparedness, 2018–2019
date: 2020-03-19
extension: .txt
mime: text/plain
words: 6156
sentence: 221
flesch: 41
cache: cache/cord-004639-qwxkn0j0.txt
txt: txt/cord-004639-qwxkn0j0.txt
summary:
  The WHO recommends EVD preparedness activities in countries with close proximity to EVD epicenters to enable them respond should there be any importation of EVD cases. We describe Uganda’s experience in EVD preparedness.


id: cord-002500-9p2n8tjx
author: Lambe, Teresa
date: 2017-05-26
extension: .txt
mime: text/plain
words: 7337
sentence: 228
flesch: 31
cache: cache/cord-002500-9p2n8tjx.txt
txt: txt/cord-002500-9p2n8tjx.txt
title:
  A review of Phase I trials of Ebola virus vaccines: what can we learn from the race to develop novel vaccines?

summary:
  key: cord-002500-9p2n8tjx authors: Lambe, Teresa; Bowyer, Georgina; Ewer, Katie J title: A review of Phase I trials of Ebola virus vaccines: what can we learn from the race to develop novel vaccines? date: 2017-05-26 journal: Philos Trans R Soc Lond B Biol Sci DOI: 10.1098/rstb.2016.0295 sha: doc_id: 2500 cord_uid: 9p2n8tjx Sporadic outbreaks of Ebola virus infection have been documented since the mid-Seventies and viral exposure can lead to lethal haemorrhagic fever with case fatalities as high as 90%. We discuss here the different aspects of the immune assays currently used in the Phase I clinical trials for Ebola virus vaccines, and draw comparisons across the immune outputs where possible; various trials have examined both cellular and humoral immunity in European and African cohorts.


id: cord-017903-92hnaiyc
author: Cieslak, Theodore J.
date: 2018-07-07
extension: .txt
mime: text/plain
words: 7499
sentence: 302
flesch: 43
cache: cache/cord-017903-92hnaiyc.txt
txt: txt/cord-017903-92hnaiyc.txt
title:
  Communicable Diseases and Emerging Pathogens: The Past, Present, and Future of High-Level Containment Care

summary:
  The 2014-2016 outbreak of Ebola virus disease (EVD) in West Africa involved at least 28,616 cases with 11,310 deaths [5] . The Emory Wheel Ebola outbreak in West Africa Ebola and Marburg haemorrhagic fever Clinical management of Ebola virus disease in the United States and Europe Fruit bats as reservoirs of Ebola virus Multi-National PREVAIL II Study Team, et al.


id: cord-356242-tydil7d7
author: Wannier, S. Rae
date: 2019-07-26
extension: .txt
mime: text/plain
words: 4555
sentence: 158
flesch: 47
cache: cache/cord-356242-tydil7d7.txt
txt: txt/cord-356242-tydil7d7.txt
title:
  Estimating the impact of violent events on transmission in Ebola virus disease outbreak, Democratic Republic of the Congo, 2018–2019

summary:
  Ebola Virus Disease The impact of control strategies and behavioural changes on the elimination of Ebola from Lofa County Transmission dynamics and final epidemic size of Ebola Virus disease outbreaks with varying interventions Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread On the theoretical specification and sampling properties of autocorrelated timeseries Prise en charge des malades et des défunts lors de l'épidémie de fièvre hémorragique due au virus ebola d'octobre à décembre Ebola response suffers another setback, as WHO evacuates some staff after attack s Redfield: it could take another year to control Ebola in DRC Ebola response teams scrambling to care for patients after attacks set back efforts Ebola response is working, WHO director-general says, amid criticism and violence On a knife edge': Ebola outbreak threatens to escalate as violence rises Discovery and description of Ebola Zaire Virus in 1976 and relevance to the West African epidemic during 2013-2016 Outbreak of Ebola hemorrhagic fever -Uganda Transmission dynamics and control of Ebola virus disease (EVD): a review What's Worse Than Ebola? The outbreak was subcritical (R < 1.0, non-sustaining transmission) in zones without violent events reported by WHO (World Health Organization Regional Office for Africa, 2019), while it was supercritical (with estimated R > 1.0, continued transmission) in zones with reported violent events, suggesting that ongoing violence is likely perpetuating an otherwise declining outbreak.


id: cord-002885-dhdyxnr3
author: Den Boon, Saskia
date: 2018-03-09
extension: .txt
mime: text/plain
words: 8416
sentence: 365
flesch: 52
cache: cache/cord-002885-dhdyxnr3.txt
txt: txt/cord-002885-dhdyxnr3.txt
title:
  Incorporating health workers’ perspectives into a WHO guideline on personal protective equipment developed during an Ebola virus disease outbreak

summary:
  However, through comments from health workers it became clear that they indeed cope with discomfort because the PPE makes them feel safe and we have added the following sentence to the discussion: Health workers accept a certain degree of discomfort in return for the protection provided by PPE. key: cord-002885-dhdyxnr3 authors: Den Boon, Saskia; Vallenas, Constanza; Ferri, Mauricio; Norris, Susan L. title: Incorporating health workers’ perspectives into a WHO guideline on personal protective equipment developed during an Ebola virus disease outbreak date: 2018-03-09 journal: F1000Res DOI: 10.12688/f1000research.12922.2 sha: doc_id: 2885 cord_uid: dhdyxnr3 Background: Ebola virus disease (EVD) health facility transmission can result in infection and death of health workers.


id: cord-259754-7skgb6eu
author: Chowell, Gerardo
title: Transmission dynamics and control of Ebola virus disease (EVD): a review
date: 2014-10-10
extension: .txt
mime: text/plain
words: 8285
sentence: 335
flesch: 42
cache: cache/cord-259754-7skgb6eu.txt
txt: txt/cord-259754-7skgb6eu.txt
summary:
  Figure 6 illustrates the role of the size of spillover events (for example, the number of infectious cases initially introduced in the population) in triggering Ebola epidemics in naive populations by showing that the probability that a major epidemic occurs rapidly increases as a function of the initial number of Ebola cases. A review of key epidemiological parameters of EVD and our current understanding of the transmission dynamics and the effect of basic control interventions against this disease would be useful for guiding and assessing the potential effectiveness of control interventions during Ebola outbreaks.


id: cord-286548-7or373vf
author: Ayebare, Rodgers
title: Leveraging investments in Ebola preparedness for COVID-19 in Sub-Saharan Africa
date: 2020-03-18
extension: .txt
mime: text/plain
words: 1981
sentence: 83
flesch: 40
cache: cache/cord-286548-7or373vf.txt
txt: txt/cord-286548-7or373vf.txt
summary:
  Although challenges remain, African countries that have been supported for EVD preparedness in ongoing and past EVD outbreaks have capacities that can be enhanced for the COVID-19 preparedness and response. Biological differences between Ebola virus and SARS-CoV-2 in the mode of transmission and case presentation will limit some benefits of EVD preparedness.


id: cord-283812-ocfjj79v
author: Blumberg, Lucille
date: 2016-06-15
extension: .txt
mime: text/plain
words: 2836
sentence: 96
flesch: 39
cache: cache/cord-283812-ocfjj79v.txt
txt: txt/cord-283812-ocfjj79v.txt
title:
  Hosting of mass gathering sporting events during the 2013–2016 Ebola virus outbreak in West Africa: experience from three African countries

summary:
  European Football Championship Finals: planning for a health legacy Olympic and Paralympic Games: public health surveillance and epidemiology Hajj: infectious disease surveillance and control Global perspectives for prevention of infectious diseases associated with mass gatherings Communicable diseases as health risks at mass gatherings other than Hajj: what is the evidence? Ebola virus diseases outbreak Rapid spread of Zika virus in the Americas-implications for public health preparedness for mass gatherings at the 2016 Brazil Olympic Games Yellow fever cases in Asia: primed for an epidemic Why is the yellow fever outbreak in Angola a 'threat to the entire world'?


id: cord-283181-7f0ljuk6
author: Parisot, Nelly
title: Commentary
date: 2014-12-18
extension: .txt
mime: text/plain
words: 1760
sentence: 62
flesch: 37
cache: cache/cord-283181-7f0ljuk6.txt
txt: txt/cord-283181-7f0ljuk6.txt
summary:
  Ebola virus disease in West Africa-the first 9 months of the epidemic and forward projections Ebola haemorrhagic fever Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients Spectrum of disease and relation to place of exposure among ill returned travelers Outbreak of filovirus hemorrhagic fever: time to refocus on the patient Basic clinical and laboratory features of filoviral hemorrhagic fever Assessment of the risk of Ebola virus transmission from bodily fluids and fomites Ebola haemorrhagic fever outbreak in Masindi district, Uganda: outbreak description and lessons learned Impact Factor Impact Factor score, one of many metrics of a journal's influence, is a measure of the frequency with which the average article in a journal has been cited over a given period of time Impact Factor rose to an all-time high this year, to 4.333. Most patients with fever and other constitutional symptoms who are from endemic regions and presenting to EDs in the United States are more likely to have illness caused by something other than Ebola virus, including malaria, rickettsial infections, dengue, Salmonella typhi and paratyphi infections, and Lassa fever.


id: cord-020610-hsw7dk4d
author: Thys, Séverine
date: 2019-10-12
extension: .txt
mime: text/plain
words: 9758
sentence: 349
flesch: 41
cache: cache/cord-020610-hsw7dk4d.txt
txt: txt/cord-020610-hsw7dk4d.txt
title:
  Contesting the (Super)Natural Origins of Ebola in Macenta, Guinea: Biomedical and Popular Approaches

summary:
  Furthermore, it raises the question of whether there is evidence to indicate and confirm that 'bushmeat'-related information included in public health campaigns in the region actually reduced Ebola transmission. Bulletin de l'Académie vétérinaire de France Inclusivity and the Rogue Bats and the War Against the Invisible Enemy About the natural reservoir for Ebola virus see The Evolution of Ebola Virus:


id: cord-293221-gf9wy4a9
author: Idowu, Abiodun Benjamin
date: 2020-08-31
extension: .txt
mime: text/plain
words: 4437
sentence: 222
flesch: 56
cache: cache/cord-293221-gf9wy4a9.txt
txt: txt/cord-293221-gf9wy4a9.txt
title:
  Ebola virus disease in the eyes of a rural, agrarian community in Western Nigeria: a mixed method study

summary:
  Results of a qualitative study A time for fear: local, national and international responses to a large EVD outbreak in Uganda Cultural contexts of Ebola in northern Uganda Modelling the role of public health education in Ebola virus disease outbreaks in Sudan The Liberia Ministry of Health. In 2014; the deadliest, most widespread (affected ten countries), EVD outbreak that lasted approximately 2 years occurred making it a global emergency


id: cord-011129-btaxvmsr
author: Di Paola, Nicholas
title: Viral genomics in Ebola virus research
date: 2020-05-04
extension: .txt
mime: text/plain
words: 9445
sentence: 304
flesch: 28
cache: cache/cord-011129-btaxvmsr.txt
txt: txt/cord-011129-btaxvmsr.txt
summary:
  identification of transmission routes using pathogen deep-sequence data The pathogenesis of Ebola virus disease Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus Characterization of host immune responses in Ebola virus infections Tissue-based class control: the other side of tolerance Uveal involvement in Marburg virus disease Spermatogene Übertragung des Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo Marburg-virus disease in Kenya Ebola virus transmission caused by persistently infected survivors of the 2014-2016 outbreak in West Africa Resurgence of Ebola virus disease in Guinea linked to a survivor with virus persistence in seminal fluid for more than 500 days New evidence of long-lasting persistence of Ebola virus genetic material in semen of survivors Ebola virus persistence in semen of male survivors Active Ebola virus replication and heterogeneous evolutionary rates in EVD survivors Post-Ebola syndrome Sequelae of Ebola virus disease: the emergency within the emergency Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys Ebola virus disease complicated by late-onset encephalitis and polyarthritis Late Ebola virus relapse causing meningoencephalitis: a case report An update on ocular complications of Ebola virus disease Persistence of Ebola virus in ocular fluid during convalescence Ocular immune privilege and transplantation Ebola RNA persistence in semen of Ebola virus disease survivors -final report Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo A longitudinal study of Ebola sequelae in Liberia Persistence and sexual transmission of filoviruses Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses Persistent Marburg virus infection in the testes of nonhuman primate survivors A case of human Lassa virus infection with robust acute T-cell activation and long-term virus-specific T-cell responses Possible sexual transmission of Crimean-Congo hemorrhagic fever Lassa fever: epidemiology, clinical features, and social consequences Persistent Crimean-Congo hemorrhagic fever virus infection in the testes and within granulomas of non-human primates with latent tuberculosis Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report Persistent infection with Ebola virus under conditions of partial immunity Ebola virus persistence in breast milk after no reported illness: a likely source of virus transmission from mother to child Immune-mediated systemic vasculitis as the proposed cause of sudden-onset sensorineural hearing loss following Lassa virus exposure in cynomolgus macaques Persistence of Lassa virus associated with severe systemic arteritis in convalescing guinea pigs (Cavia porcellus) High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon Prevalence of infection among asymptomatic and paucisymptomatic contact persons exposed to Ebola virus in Guinea: a retrospective, cross-sectional observational study Asymptomatic infection and unrecognised Ebola virus disease in Ebola-affected households in Sierra Leone: a cross-sectional study using a new non-invasive assay for antibodies to Ebola virus Human asymptomatic Ebola infection and strong inflammatory response Risk factors associated with Ebola and Marburg viruses seroprevalence in blood donors in the Republic of Congo Risk factors for Zaire ebolavirusspecific IgG in rural Gabonese populations Unique human immune signature of Ebola virus disease in Guinea Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity Use of reverse genetics to inform Ebola outbreak responses Therapeutic strategies to target the Ebola virus life cycle Effects of life history and ecology on virus evolutionary potential Role of antibodies in protection against Ebola virus in nonhuman primates immunized with three vaccine platforms Immune parameters correlate with protection against Ebola virus infection in rodents and nonhuman primates Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!) Here, we describe how genomics has been historically used to investigate Ebola virus disease outbreaks and how new technologies allow for rapid, large-scale data generation at the point of care.


id: cord-272991-opvs2ejd
author: Masiira, Ben
date: 2020-10-13
extension: .txt
mime: text/plain
words: 3496
sentence: 161
flesch: 47
cache: cache/cord-272991-opvs2ejd.txt
txt: txt/cord-272991-opvs2ejd.txt
title:
  Building a new platform to support public health emergency response in Africa: the AFENET Corps of Disease Detectives, 2018–2019

summary:
  key: cord-272991-opvs2ejd authors: Masiira, Ben; Antara, Simon N; Kazoora, Herbert B; Namusisi, Olivia; Gombe, Notion T; Magazani, Alain N; Nguku, Patrick M; Kazambu, Ditu; Gitta, Sheba N; Kihembo, Christine; Sawadogo, Bernard; Bogale, Tatek A; Ohuabunwo, Chima; Nsubuga, Peter; Tshimanga, Mufuta title: Building a new platform to support public health emergency response in Africa: the AFENET Corps of Disease Detectives, 2018–2019 date: 2020-10-13 journal: BMJ Glob Health DOI: 10.1136/bmjgh-2020-002874 sha: doc_id: 272991 cord_uid: opvs2ejd Public health emergency (PHE) response in sub-Saharan Africa is constrained by inadequate skilled public health workforce and underfunding. ► Public health emergency response in sub-Saharan Africa is still constrained by underfunding.


id: cord-269770-7hau5yge
author: MacIntyre, C. Raina
date: 2014-09-08
extension: .txt
mime: text/plain
words: 3406
sentence: 106
flesch: 36
cache: cache/cord-269770-7hau5yge.txt
txt: txt/cord-269770-7hau5yge.txt
title:
  Respiratory protection for healthcare workers treating Ebola virus disease (EVD): Are facemasks sufficient to meet occupational health and safety obligations?

summary:
  Fact Sheet: Basic Information about SARS Available at Availability, consistency and evidence-base of policies and guidelines on the use of mask and respirator to protect hospital health care workers: a global analysis Combined simian hemorrhagic fever and Ebola virus infection in cynomolgus monkeys National Guidelines for Recognition and Management of Viral Haemorrhagic Fevers (Draft Guidelines) Available at Guidelines for Certification of a Physical Containment Level 4 Facility -Version 2 Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory Infection prevention as ''a show'': a qualitative study of nurses' infection prevention behaviours Use of surgical face masks to reduce the incidence of the common cold among health care workers in Japan: a randomized controlled trial Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus Ebola fever: reconciling Ebola planning with Ebola risk in US hospitals Replication, pathogenicity, shedding, and transmission of Zaire Ebola virus in pigs Fruit bats as reservoirs of Ebola virus Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial A cluster randomized clinical trial comparing fittested and non-fit-tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers A randomized clinical trial of three options for N95 respirators and medical masks in health workers Quantifying the risk of respiratory infection in healthcare workers performing high-risk procedures Efficacy of face masks and respirators in preventing upper respiratory tract bacterial colonization and co-infection in hospital healthcare workers A school outbreak of Norwalk-like virus: evidence for airborne transmission Is respiratory protection appropriate in the Ebola response Environmental transmission of SARS at Amoy Gardens Facial protective equipment, personnel, and pandemics: impact of the pandemic (H1N1) 2009 virus on personnel and use of facial protective equipment An outbreak of Ebola in Uganda Interim Biosafety Guidelines for Laboratories Handling Specimens from Patients Under Investigation for Ebola Virus Disease Available at Interim Guidance -Ebola Virus Disease: Infection Prevention and Control Measures for Borders, Healthcare Settings and Self-monitoring at Home Available at Unexpected Ebola virus in a tertiary setting: clinical and epidemiologic aspects Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: risk factors for patients without a reported exposure Airborne transmission of communicable infection-the elusive pathway Guideline for isolation precautions: preventing transmission of infectious agents in health care settings Filovirus Haemorrhagic Fever Guideline Practical Recommendations to the Attention of Healthcare Professionals and Health Authorities Regarding the Identification of and Care Delivered to Suspected or Confirmed Carriers of Highly Contagious Viruses (of the Ebola or Marburg type) in the Context of an Epidemic Outbreak in West Africa Available at: www.shea-online.org/Portals/0/PDFs/Belgian-guidelines-ebola Aerosol transmission of influenza A virus: a review of new studies Ebola virus Disease (EVD) Outbreaks in West Africa. Some diseases exclusively transmit through the airborne route in natural setting (e.g. tuberculosis), while other diseases mainly transmit through the droplet or contact modes but short range respiratory aerosols are generated during high risk procedures which increases the risk of infection transmission (Roy and Milton, 2004) .


id: cord-269476-lrk4ty99
author: Mohammed, Abdulaziz
date: 2015-08-27
extension: .txt
mime: text/plain
words: 3930
sentence: 156
flesch: 43
cache: cache/cord-269476-lrk4ty99.txt
txt: txt/cord-269476-lrk4ty99.txt
title:
  An evaluation of psychological distress and social support of survivors and contacts of Ebola virus disease infection and their relatives in Lagos, Nigeria: a cross sectional study − 2014

summary:
  In a descriptive cross sectional study, we used General Health Questionnaire to assess psychological distress and Oslo Social Support Scale to assess social support among 117 participants who survived EVD, listed as EVD contacts or their relatives at Ebola Emergency Operation Center in Lagos, Nigeria. The evaluation could not interview the anticipated number of relatives because some of the contacts did not inform their immediate family members about their status as EVD contacts and therefore could not be interviewed.


id: cord-300133-yc2wxgid
author: Martínez, Miguel J.
title: Ebola Virus Infection: Overview and Update on Prevention and Treatment
date: 2015-09-12
extension: .txt
mime: text/plain
words: 4303
sentence: 171
flesch: 42
cache: cache/cord-300133-yc2wxgid.txt
txt: txt/cord-300133-yc2wxgid.txt
summary:
  International Scientific and Technical Committee Large-scale convalescent blood and plasma transfusion therapy for Ebola virus disease Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease Emergency evaluation of convalescent plasma for Ebola viral disease (EVD) in Guinea (Ebola-Tx) Use of convalescent whole blood or plasma collected from patients recovered from Ebola virus disease for transfusion, as an emprical treatment during outbreaks First Ebola treatment is approved by WHO Position paper on collection and use of convalescent plasma or serum as an element in filovirus outbreak response Acute respiratory distress syndrome after convalescent plasma use: treatment of a patient with Ebola virus disease Antibody-dependent enhancement of Ebola virus infection Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp Clinical care of two patients with Ebola virus disease in the United States Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors Putative investigational therapeutics in the treatment of patients with known Ebola infection Accessed 27 Characterization of host immune responses in Ebola virus infections Evasion of the interferon-mediated antiviral response by filoviruses How Ebola virus counters the interferon system Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections Interferon-beta therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever Clinical features and pathobiology of Ebolavirus infection Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever ARCA biopharma receives FDA orphan drug designation for rNAPc2 as a potential treatment for Ebola Ebola virus vaccines: an overview of current approaches Evaluation in nonhuman primates of vaccines against Ebola virus Role of VP30 phosphorylation in the Ebola virus replication cycle Perspectives from West Africa Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients Clinical predictors of mortality in patients with Ebola virus disease Clinical features of patients with Ebola virus disease in Sierra Leone Ebola haemorrhagic fever Lethal experimental infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus Ebola (Ebola virus disease), guidance for collection, transport and submission of specimens for Ebola virus testing World Health Organization.


id: cord-017569-fv88n70v
author: Hewlett, Angela
title: Viral Hemorrhagic Fever Preparedness
date: 2017-09-10
extension: .txt
mime: text/plain
words: 11182
sentence: 433
flesch: 39
cache: cache/cord-017569-fv88n70v.txt
txt: txt/cord-017569-fv88n70v.txt
summary:
  The design of a HLCC unit should serve to minimize nosocomial transmission of infectious diseases by establishing a contained clinical isolation unit capable of housing all facets of patient care. Press conferences with infectious diseases experts and others involved in patient care should be held to provide timely updates.


id: cord-327641-hqnem2zs
author: Ji, Ying-Jie
title: Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone
date: 2016-11-03
extension: .txt
mime: text/plain
words: 5872
sentence: 256
flesch: 54
cache: cache/cord-327641-hqnem2zs.txt
txt: txt/cord-327641-hqnem2zs.txt
summary:
  Multivariate analyses showed that blood viral load (P = 0.005), confusion (P = 0.010), abdominal pain (P = 0.003), conjunctivitis (P = 0.035), and vomiting (P = 0.004) were factors independently associated with the outcomes of EVD patients. Factors such as high blood viral load, confusion, abdominal pain, vomiting and conjunctivitis were associated with poor prognosis for EVD patients.


id: cord-314460-dbrp4vxc
author: Gibbs, Shawn G.
title: Review of Literature for Air Medical Evacuation High-Level Containment Transport
date: 2019-10-31
extension: .txt
mime: text/plain
words: 4808
sentence: 179
flesch: 38
cache: cache/cord-314460-dbrp4vxc.txt
txt: txt/cord-314460-dbrp4vxc.txt
summary:
  Since that epidemic, multiple groups have developed AE HLCT systems enabling simultaneous isolation and care of multiple patients; these include the US Department of State Containerized Bio-Containment System and the US Department of Defense (DoD) Transport Isolation System. Zone designation lends the ability to transport multiple patients at different stages of disease progression for the same disease or, more likely, to transport both suspected and confirmed patients.


id: cord-356327-kxyo4rfv
author: Stephens, David S.
title: Ebola Virus Disease: Experience and Decision Making for the First Patients outside of Africa
date: 2015-07-28
extension: .txt
mime: text/plain
words: 4047
sentence: 165
flesch: 40
cache: cache/cord-356327-kxyo4rfv.txt
txt: txt/cord-356327-kxyo4rfv.txt
summary:
  Further, ID and other specialty fellows have been integrated into the management planning for EVD patients, educated on the broader policies and procedures of the unit, are involved with the development of protocols for the management of Ebola patients who present to the Emergency Department (ED) or other clinical settings, and are educated about the collective experiences in treating the patients. The Task Force includes leaders from across the campus and is directed at facilitating cross-cutting institutional initiatives such as EVD research, education and training activities, input into public policy issues around EVD, development of an institutional travel policy to West Africa, establishing procedures for trainee involvement in Ebola care, and the support of the humanitarian, research and control efforts in West Africa.


id: cord-018364-b06084r1
author: LaBrunda, Michelle
title: The Emerging Threat of Ebola
date: 2019-06-07
extension: .txt
mime: text/plain
words: 13506
sentence: 710
flesch: 55
cache: cache/cord-018364-b06084r1.txt
txt: txt/cord-018364-b06084r1.txt
summary:
  Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients Interim guidance for healthcare workers providing care in West African countries affected by the Ebola outbreak: limiting heat burden while wearing personal protective equipment (PPE) Viral bioterrorism: learning the lesson of Ebola virus in West Africa CDC announces active post-arrival monitoring for travelers from impacted countries Enhanced Ebola screening to start at five U.S. airports and new tracking program for all people entering U.S. from Ebola-affected countries History of quarantine Enhanced Ebola screening to start at five U.S. airports and new tracking program for all people entering U.S. from Ebola-affected countries History of quarantine Protecting borders: the road to zero Severe meningoencephalitis in a case of Ebola virus disease: a case report Possible sexual transmission of Ebola virus -Liberia Persistence of Ebola virus in various body fluids during convalescence: evidence and implications for disease transmission and control The world's ten largest megacities Ebola virus-related encephalitis Survey of Ebola viruses in frugivorous and insectivorous bats in Guinea, Cameroon, and the Democratic Republic of the Congo Transmissibility and pathogenicity of Ebola virus: a systematic review and meta-analysis of household secondary attack rate and asymptomatic infection Ebola RNA persistence in semen of Ebola virus disease survivors -final report Demographia world urban areas: 14th annual edition Epidemiology and risk factors for Ebola virus disease in Sierra Leone -23 Ebola in Nigeria and Senegal: stable -for the moment (n.d.) Retrieved December Infection prevention and control measures for Ebola virus disease Transmission dynamics of Ebola virus disease and intervention effectiveness in Sierra Leone Use of viremia to evaluate the baseline case fatality ratio of Ebola virus disease and inform treatment studies: a retrospective cohort study Air trafic by the numbers Ebola haemorrhagic fever Variability in intrahousehold transmission of Ebola virus, and estimation of the household secondary attack rate The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses Confronting the threat of bioterrorism: realities, challenges, and defensive strategies Cultural context of Ebola in northern Ugands Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study Infection Prevention and Control Recommendations for Hospitalized Patients Under Investigation (PUIs) for Ebola Virus Disease (EVD) in U Interim Guidance for Management of Survivors of Ebola Virus Disease Late Ebola virus relapse causing meningoencephalitis: a case report Disability among Ebola survivors and their close contacts in Sierra Leone: a retrospective case-controlled cohort study Monitoring of prognostic laboratory markers in Ebola virus disease Lethal experimential infection of rhesus monkeys with Ebola-Zaire (Mayinga) virus by the oral and conjunctival route of exposure Experimental inoculation of Egyptian Rousette bats (Rousettus aegyptiacus) with viruses of the ebolavirus and Marburgvirus genera An overview of Ebola virus disease Some airports have a new security routine: taking your temperature The worship of God in African traditional religion a Nigerian perspective The reemergence of Ebola hemorrhagic fever Democreatic Republic of the Congo, 1995, Commission de Lutte Contre les Epidemies a Kikwit Ebola virus disease in health care workers -Sierra Leone Some airports have a new security routine: taking your temperature.


id: cord-300080-l0fyxtva
author: Venkat, Arvind
date: 2015-03-10
extension: .txt
mime: text/plain
words: 8371
sentence: 271
flesch: 37
cache: cache/cord-300080-l0fyxtva.txt
txt: txt/cord-300080-l0fyxtva.txt
title:
  Ethical Issues in the Response to Ebola Virus Disease in US Emergency Departments: A Position Paper of the American College of Emergency Physicians, the Emergency Nurses Association and the Society for Academic Emergency Medicine

summary:
  Another ethical consideration is the reputational impact upon hospitals caring for Ebola patients. It is therefore imperative, in the face of a disease such as Ebola that has generated such public scrutiny and at times hysteria, for hospitals to be cognizant of their ethical responsibility to support the efforts of designated treatment centers as well as frontline facilities that might encounter Ebola patients and potentially be perceived adversely by the public.


id: cord-265017-byyx2y47
author: Ryan, Jeffrey R.
title: Seeds of Destruction
date: 2016-03-25
extension: .txt
mime: text/plain
words: 9272
sentence: 463
flesch: 52
cache: cache/cord-265017-byyx2y47.txt
txt: txt/cord-265017-byyx2y47.txt
summary:
  Biological agents are no exception to this rule. As such, biowarfare (biological warfare) has a historical aspect to it that must be considered here because advances in the use of biological agents over the last century are one of the main reasons why bioterrorism exists today.


id: cord-030370-89n13hml
author: Brown, Colin S.
title: Ebola Virus Disease in the Obstetric Population
date: 2019-04-11
extension: .txt
mime: text/plain
words: 17490
sentence: 686
flesch: 44
cache: cache/cord-030370-89n13hml.txt
txt: txt/cord-030370-89n13hml.txt
summary:
  The risk of fluid overload must be balanced with the propensity of EVD patients to be fluid depleted and anuric. Given the overwhelming benefit to breastfeeding, particularly in resource-poor settings, current CDC guidelines support routine breastfeeding of the neonate born to EVD survivors, with case-by-case evaluation to neonates born to suspect or confirmed EVD patients [73] .


id: cord-330647-w1bpeqzg
author: Wong, Samson Sai-Yin
title: Ebola virus disease in nonendemic countries
date: 2015-05-31
extension: .txt
mime: text/plain
words: 8638
sentence: 333
flesch: 32
cache: cache/cord-330647-w1bpeqzg.txt
txt: txt/cord-330647-w1bpeqzg.txt
summary:
  Marburg hemorrhagic fever associated with multiple genetic lineages of virus Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection Multiple Ebola virus transmission events and rapid decline of central African wildlife A serological survey of Ebola virus infection in central African nonhuman primates Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo Replication, pathogenicity, shedding, and transmission of Zaïre ebolavirus in pigs Review of Ebola virus infections in domestic animals Ebola virus antibody prevalence in dogs and human risk The natural history of Ebola virus in Africa Ebola and Marburg virus disease epidemics: preparedness, alert, control, and evaluation Ebola hemorrhagic fever transmission and risk factors of contacts Ebola virus disease in southern Sudan: hospital dissemination and intrafamilial spread Transmission of Ebola hemorrhagic fever: a study of risk factors in family members Assessment of the risk of Ebola virus transmission from bodily fluids and fomites Emergence of Zaïre Ebola virus disease in Guinea Clinical manifestations and case management of Ebola haemorrhagic fever caused by a newly identified virus strain Transmission of Ebola virus from pigs to nonhuman primates Evaluation of transmission risks associated with in vivo replication of several high containment pathogens in a biosafety level 4 laboratory Lethal experimental infections of rhesus monkeys by aerosolized Ebola virus Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: risk factors for patients without a reported exposure World Health Organization. a compendium of 40 years of epidemiological, clinical, and laboratory studies ELISA for the detection of antibodies to Ebola viruses Enzyme-linked immunosorbent assay for detection of filovirus species-specific antibodies Development of an immunofiltrationbased antigen-detection assay for rapid diagnosis of Ebola virus infection Enzyme immunosorbent assay for Ebola virus antigens in tissues of infected primates Rapid and simple detection of Ebola virus by reverse transcription-loop-mediated isothermal amplification Development and evaluation of a simple assay for Marburg virus detection using a reverse transcription-loop-mediated isothermal amplification method Comprehensive multiplex one-step real-time TaqMan qRT-PCR assays for detection and quantification of hemorrhagic fever viruses Simultaneous detection of CDC category A DNA and RNA bioterrorism agents by use of multiplex PCR & RT-PCR enzyme hybridization assays Detection of Ebola virus in oral fluid specimens during outbreaks of Ebola virus hemorrhagic fever in the Republic of Congo Detection and molecular characterization of Ebola viruses causing disease in human and nonhuman primates Laboratory diagnosis of Ebola hemorrhagic fever during an outbreak in Yambio, Sudan Clinical management of filovirus-infected patients Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys Interferon-beta therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients.


id: cord-340194-ibli36rq
author: To, Kelvin K.W.
title: Ebola virus disease: a highly fatal infectious disease reemerging in West Africa
date: 2014-11-29
extension: .txt
mime: text/plain
words: 8875
sentence: 409
flesch: 47
cache: cache/cord-340194-ibli36rq.txt
txt: txt/cord-340194-ibli36rq.txt
summary:
  Are bats spreading Ebola across sub-Saharan Africa? Transmission of Ebola hemorrhagic fever: a study of risk factors in family members Assessment of the risk of Ebola virus transmission from bodily fluids and fomites Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo The survival of filoviruses in liquids, on solid substrates and in a dynamic aerosol Ebola virus: from discovery to vaccine A case of Ebola virus infection Russian scientist dies after Ebola lab accident Viral haemorrhagic fevers in healthcare settings Discovery of swine as a host for the Reston ebolavirus Ebola virus antibody prevalence in dogs and human risk Multiple Ebola virus transmission events and rapid decline of central African wildlife Interspecies transmission and emergence of novel viruses: lessons from bats and birds Bats as a continuing source of emerging infections in humans Fruit bats as reservoirs of Ebola virus Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo Ebola virus antibodies in fruit bats Reston Ebolavirus antibodies in bats, the Philippines Serological evidence of ebolavirus infection in bats, China Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China Reston virus in domestic pigs in China Serological evidence of Ebola virus infection in Indonesian orangutans Current perspectives on the phylogeny of Filoviridae Characterization of filoviruses based on differences in structure and antigenicity of the virion glycoprotein A new Ebola virus nonstructural 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id: cord-288734-xinkqs6u
author: Muñoz-Fontela, César
title: Ebola Virus Disease in Humans: Pathophysiology and Immunity
date: 2017-03-30
extension: .txt
mime: text/plain
words: 9966
sentence: 261
flesch: 27
cache: cache/cord-288734-xinkqs6u.txt
txt: txt/cord-288734-xinkqs6u.txt
summary:
  Perhaps one of the most surprising findings has been the low overall number of human cases presenting with bleeding (Schieffelin et al. 2014) , as well as the lack of correlation between bleeding and disease severity (Schieffelin et al. 2014; McElroy et al. 2014a, b) . Furthermore, in the Western African outbreak, hemorrhagic manifestations were rarely reported; fewer than 15% of all patients from Liberia and Sierra Leone had any bleeding symptom recorded (Chertow et al. 2014; Schieffelin et al. 2014; Lado et al. 2015; Yan et al. 2015; Dallatomasina et al. 2015; Li et al. 2016; Qin et al. 2015) , but two reports from a single center in Guinea reported bleeding in 51 and 26% of patients (Barry et al. 2014;


id: cord-006182-kck5e1ry
title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada
date: 2019-10-01
extension: .txt
mime: text/plain
words: 87787
sentence: 4467
flesch: 45
cache: cache/cord-006182-kck5e1ry.txt
txt: txt/cord-006182-kck5e1ry.txt
summary:
  Whether a laboratory response in coagulation dosing, laboratory response, hemostatic efficacy and patient outcomes. A project aimed at improving DI management through predictive assessments and DDAVP protocols could potentially improve patient outcomes.


id: cord-006870-f5w6fw6q
title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting
date: 2017-09-19
extension: .txt
mime: text/plain
words: 122395
sentence: 6375
flesch: 46
cache: cache/cord-006870-f5w6fw6q.txt
txt: txt/cord-006870-f5w6fw6q.txt
summary:
  The best model fit was for good outcome (modified Rankin Score 0-2 equivalents) based on % patients with WFNS 4-5 and age (R2=0.54; p<0.001). Decreasing time spent in cervical spinal immobilization could improve patient care by allowing greater access to / range-of-motion of the neck, increasing patient comfort, and decreasing skin breakdown.


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