# bib

id: cord-254291-y8xvh6hs
author: Yamanaka, Miles
title: Nucleotide Sequence of the Inter-Structural Gene Region of Feline Infectious Peritonitis Virus
date: 1998
extension: .txt
mime: text/plain
words: 833
sentence: 38
flesch: 63
cache: cache/cord-254291-y8xvh6hs.txt
txt: txt/cord-254291-y8xvh6hs.txt
summary:
  A related sequence, CTAAAT, is present upstream of FIPV ORF 3b. In contrast, an amber codon limits FIPV ORF 3b to only 40 residues while ORF 3b of the Purdue strain of TGEV extends 244 amino acids (3) .


id: cord-255873-18zmvlmk
author: Wang, Jinshan
date: 2014-11-14
extension: .txt
mime: text/plain
words: 1520
sentence: 64
flesch: 50
cache: cache/cord-255873-18zmvlmk.txt
txt: txt/cord-255873-18zmvlmk.txt
title:
  Crystallization and preliminary crystallographic study of Feline infectious peritonitis virus main protease in complex with an inhibitor

summary:
  In this study, we report the crystallization The coding sequence for FIPV main protease was synthesized and was cloned into the vector pGEX-6P-1 using the BamHI and XhoI restriction sites (Table 1 ). Isopropyl -d-1-thiogalactopyranoside was then added to a final concentration of 0.5 mM and the cultures were induced to express FIPV main protease at 289 K for 16 h. Thereafter, centrifugation was used to harvest the cells and the bacterial pellets were resuspended in PBS (140 mM NaCl, 10 mM


id: cord-283739-p7b4mtbl
author: Theerawatanasirikul, Sirin
date: 2020-09-07
extension: .txt
mime: text/plain
words: 1607
sentence: 51
flesch: 44
cache: cache/cord-283739-p7b4mtbl.txt
txt: txt/cord-283739-p7b4mtbl.txt
title:
  Structural-based virtual screening and in vitro assays for small molecules inhibiting the feline coronavirus 3CL protease as a surrogate platform for coronaviruses

summary:
  prophylaxis experiment was designed to allow the entry of small compounds into the host 310 cells, and also determined that the compounds remaining in the supernatant still have a 311 sufficient viral inhibition potency. Moreover, compounds NSC282187 and NSC71097 might be able to permeate blood-358 brain barrier as shown in Supplementary Table 1 Clinical features of patients infected with 2019 novel coronavirus in Wuhan Triple combination of interferon beta-1b, 513 lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with 514 COVID-19: an open-label, randomised, phase 2 trial Mechanism of the Maturation Process Potent inhibition of feline coronaviruses with peptidyl compounds targeting 531 coronavirus 3C-like protease Broad-Spectrum Antivirals against 3C or 3C-Like Proteases 535 of Picornaviruses, Noroviruses, and Coronaviruses Characterization of SARS main protease 538 and inhibitor assay using a fluorogenic substrate LigPlot+:


id: cord-257974-kllqjn68
author: Woods, Roger D.
date: 1988
extension: .txt
mime: text/plain
words: 2335
sentence: 86
flesch: 44
cache: cache/cord-257974-kllqjn68.txt
txt: txt/cord-257974-kllqjn68.txt
title:
  Cultivation techniques for animal coronaviruses: Emphasis on feline infectious peritonitis virus, canine coronavirus, transmissible gastroenteritis virus, and porcine hemagglutinating encephalomyelitis virus

summary:
  The complete nucleotide sequence of the three major structural proteins of TGEV has been determined on cDNA clones of attenuated virus grown in ST cell culture (15,17,18,32L 9O Isolation of transmissible enteritis agent of turkeys in avian embryos Propagation of hemagglutinating encephalomyelitis virus in porcine cell culture. Basic studies on these viruses have been limited because of their fastidious growth in cell culture (14) .


id: cord-322629-kv83ekg0
author: TAKANO, Tomomi
date: 2019-04-23
extension: .txt
mime: text/plain
words: 2821
sentence: 124
flesch: 52
cache: cache/cord-322629-kv83ekg0.txt
txt: txt/cord-322629-kv83ekg0.txt
title:
  Pathogenesis of oral type I feline infectious peritonitis virus (FIPV) infection: Antibody-dependent enhancement infection of cats with type I FIPV via the oral route

summary:
  Two cats (Ab2 and Ab4) were euthanized at 15 and 18 day of post FIPV infection (dpi) with FIPV-I KU-2, respectively, when they reached the humane endpoint. It is unclear whether FIP transmits from cat to cat through the oral route of FIPV infection, and the reason for this includes that FIP is caused by oral inoculation with some FIPV strains (e.g., type II FIPV WSU 79-1146), but is not caused by other FIPV (e.g., type I FIPV KU-2 strain: FIPV-I KU-2).


id: cord-299342-l8ugjou9
author: Yaling, Zhou
date: 1988
extension: .txt
mime: text/plain
words: 2980
sentence: 114
flesch: 44
cache: cache/cord-299342-l8ugjou9.txt
txt: txt/cord-299342-l8ugjou9.txt
title:
  Porcine epidemic diarrhea virus (CV 777) and feline infectious peritonitis virus (FIPV) are antigenically related

summary:
  key: cord-299342-l8ugjou9 authors: Yaling, Zhou; Ederveen, J.; Egberink, H.; Pensaert, M.; Horzinek, M. C. title: Porcine epidemic diarrhea virus (CV 777) and feline infectious peritonitis virus (FIPV) are antigenically related date: 1988 journal: Arch Virol DOI: 10.1007/bf01315563 sha: doc_id: 299342 cord_uid: l8ugjou9 Using gut sections from pigs infected with porcine epidemic diarrhea virus (strain CV 777) and ascitic fluid from cats which had succumbed to feline infectious peritonitis (FIP), a weak cross reaction was found by immunofluorescence. We have confirmed the finding of cross reactions within one group, namely between transmissible gastroenteritis virus (TGEV) of swine, FIPV and canine enteric coronavirus, and showed that common determinants are present on all three structural polypeptides [7] .


id: cord-287157-6rwevq39
author: Kiss, I.
date: 2004-02-25
extension: .txt
mime: text/plain
words: 3036
sentence: 118
flesch: 41
cache: cache/cord-287157-6rwevq39.txt
txt: txt/cord-287157-6rwevq39.txt
title:
  Disease outcome and cytokine responses in cats immunized with an avirulent feline infectious peritonitis virus (FIPV)-UCD1 and challenge-exposed with virulent FIPV-UCD8

summary:
  Cats that developed FIP had negligible or below normal IFNresponses, save cat 527 that showed slightly elevated levels of this cytokine on the day of challenge-exposure. In contrast, immune cats failed to upregulate TNF-mRNA and one manifested strong IFN-mRNA responses.


id: cord-292908-rbn3foj3
author: Hohdatsu, T.
date: 1991-06-30
extension: .txt
mime: text/plain
words: 3257
sentence: 129
flesch: 53
cache: cache/cord-292908-rbn3foj3.txt
txt: txt/cord-292908-rbn3foj3.txt
title:
  Antigenic analysis of feline coronaviruses with monoclonal antibodies (MAbs): Preparation of MAbs which discriminate between FIPV strain 79-1146 and FECV strain 79-1683

summary:
  Similarly, among the MAbs in Group V, which react with FIPV Type II viruses alone, F6-3 reacted with CCV, and F24-1 and F49-1 reacted with the SH strain of TGEV. However, MAbs in Group V reacted with FIPV Type II viruses alone, while MAbs in Group VI reacted with the 79-1683 strain of FECV Type II alone.


id: cord-291707-dzmvjh7j
author: Tupper, G. T.
date: 1987
extension: .txt
mime: text/plain
words: 2793
sentence: 124
flesch: 53
cache: cache/cord-291707-dzmvjh7j.txt
txt: txt/cord-291707-dzmvjh7j.txt
title:
  Antigenic and biological diversity of feline coronaviruses: feline infectious peritonitis and feline enteritis virus

summary:
  The molecular weight of virus structural proteins was determined by using molecular weight standards (Sigma, St. Louis, MO). FIPV grows to higher titer, forms larger plaques and switches off host cell protein synthesis more effectively than FECV.


id: cord-258684-lq4knxgf
author: Takano, Tomomi
date: 2020-05-24
extension: .txt
mime: text/plain
words: 3716
sentence: 178
flesch: 56
cache: cache/cord-258684-lq4knxgf.txt
txt: txt/cord-258684-lq4knxgf.txt
title:
  Antiviral Effects of Hydroxychloroquine and Type I Interferon on In Vitro Fatal Feline Coronavirus Infection

summary:
  Based on this knowledge and our current study, type II FIPV may show less effect on the antiviral activity of HCQ and type I IFN, compared to type I FIPV. We investigated whether HCQ in association with interferon-ω (IFN-ω) is effective for FIPV in vitro.


id: cord-267014-3vi7pgvr
author: Vennema, H.
title: Genomic organization and expression of the 3′ end of the canine and feline enteric coronaviruses
date: 1992-11-30
extension: .txt
mime: text/plain
words: 3559
sentence: 148
flesch: 52
cache: cache/cord-267014-3vi7pgvr.txt
txt: txt/cord-267014-3vi7pgvr.txt
summary:
  They occur, for example, in the S and HE protein genes of murine hepatitis virus (MHV; Parker et al., 1989; 1. Viral Primary structure of the membrane and nucleocapsid protein genes of feline infectious peritonitis virus and immunogenicity of recombinant vaccinia viruses in kittens Genetic basis for the pathogenesis of transmissible gastroenteritis virus Mouse hepatitis virus S RNA sequence reveals that nonstructural proteins ns4 and ns5a are not essential for murine coronavirus replication.


id: cord-299904-i5c6nf18
author: Cornelissen, E.
date: 2009-04-07
extension: .txt
mime: text/plain
words: 3619
sentence: 132
flesch: 35
cache: cache/cord-299904-i5c6nf18.txt
txt: txt/cord-299904-i5c6nf18.txt
title:
  Absence of antibody-dependent, complement-mediated lysis of feline infectious peritonitis virus-infected cells

summary:
  Opsonization of the virus with complement proteins can promote phagocytosis, virolysis and interference with attachment, internalization or uncoating of the virions (Hirsch, 1982) . The fact that neutralizing antibodies are present in a cat with FIP, together with the observed enhancement of neutralization by complement in this study, indicates that cell free virus does not play an important role in the pathogenesis of FIP (de Groot-Mijnes et al., 2005) .


id: cord-258374-qht98q0l
author: Takano, Tomomi
date: 2009-04-03
extension: .txt
mime: text/plain
words: 3701
sentence: 148
flesch: 39
cache: cache/cord-258374-qht98q0l.txt
txt: txt/cord-258374-qht98q0l.txt
title:
  Neutrophil survival factors (TNF-alpha, GM-CSF, and G-CSF) produced by macrophages in cats infected with feline infectious peritonitis virus contribute to the pathogenesis of granulomatous lesions

summary:
  Risk of feline infectious peritonitis in cats naturally infected with feline coronavirus Gamma interferon/interleukin 10 balance in tissue lymphocytes correlates with down modulation of mucosal feline immunodeficiency virus infection Immune and idiopathic neutropenia Replication of feline coronaviruses in peripheral blood monocytes Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation Polymorphonuclear leukocytemediated cell and tissue injury: oxygen metabolites and their relations to human disease Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression The molecular genetics of feline coronaviruses: comparative sequence analysis of the ORF7a/7b transcription unit of different biotypes A study on the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection in feline macrophages by monoclonal antibodies Enhancement and neutralization of feline infectious peritonitis virus infection in feline macrophages by neutralizing monoclonal antibodies recognizing different epitopes The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis Spontaneous neutrophil apoptosis and regulation of cell survival by granulocyte macrophage-colony stimulating factor Asymptomatic bacteriuria in puppies with canine parvovirus infection: a cohort study Neutropenia, neutrophil dysfunction, and bacterial infection in patients with human immunodeficiency virus disease: the role of granulocyte colony-stimulating factor Epstein-Barr virus infects and induces apoptosis in human neutrophils Marrow accessory cell infection and alterations in hematopoiesis accompany severe neutropenia during experimental acute infection with feline immunodeficiency virus Virus infection of endothelial cells increases granulocyte adherence Molecular cloning and sequence determination of the peplomer protein gene of feline infectious peritonitis virus type I Comparison of the amino acid sequence and phylogenetic analysis of the peplomer, integral membrane and nucleocapsid proteins of feline, canine and porcine coronaviruses In vitro effect of recombinant human granulocyte colonystimulating factor on canine neutrophil apoptosis In vitro effect of recombinant human tumor necrosis factor-alpha on canine neutrophil apoptosis A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination The acute phase reaction Some aspects of humoral and cellular immunity in naturally occurring feline infectious peritonitis Pathogenesis of feline panleukopenia virus and canine parvovirus Programmed cell death of the normal human neutrophil: an in vitro model of senescence Feline infectious peritonitis and feline enteric coronavirus infections. In addition, the presence or absence of neutrophil survival factors was investigated in specimens collected from cats with FIP.


id: cord-290540-r0d6oaez
author: Rottier, Peter J.M.
title: The molecular dynamics of feline coronaviruses
date: 1999-09-01
extension: .txt
mime: text/plain
words: 3821
sentence: 172
flesch: 53
cache: cache/cord-290540-r0d6oaez.txt
txt: txt/cord-290540-r0d6oaez.txt
summary:
  They compared sequences of FIPV viruses from different geographic areas with those of FECV viruses from these same areas and concluded that the viruses isolated from FIP cases are most similar to the coronaviruses from the area where this particular case of FIP occurred. On the other hand we have the virulent strains which cause feline infectious peritonitis (FIP), and we then talk about FIP viruses (FIPV).


id: cord-023053-j061ywrl
author: BARLOUGH, J. E.
title: Cats, coronaviruses and coronavirus antibody tests
date: 2008-04-10
extension: .txt
mime: text/plain
words: 3612
sentence: 116
flesch: 27
cache: cache/cord-023053-j061ywrl.txt
txt: txt/cord-023053-j061ywrl.txt
summary:
  key: cord-023053-j061ywrl authors: BARLOUGH, J. E. title: Cats, coronaviruses and coronavirus antibody tests date: 2008-04-10 journal: J Small Anim Pract DOI: 10.1111/j.1748-5827.1985.tb02210.x sha: doc_id: 23053 cord_uid: j061ywrl Feline infectious peritonitis and other coronavirus infections of cats are briefly reviewed. In FIP, hypersensitization by coronavirus antibody is dependent upon the identity of the coronavirus(es) that originally incited the antibody response.


id: cord-300489-gzcb6uqw
author: Martinez, Mitzi L.
date: 1993-03-31
extension: .txt
mime: text/plain
words: 3710
sentence: 134
flesch: 42
cache: cache/cord-300489-gzcb6uqw.txt
txt: txt/cord-300489-gzcb6uqw.txt
title:
  Detection of feline infectious peritonitis virus infection in cell cultures and peripheral blood mononuclear leukocytes of experimentally infected cats using a biotinylated cDNA probe

summary:
  Feline infectious peritonitis: an immune-mediated coronavirus vasculitis Serodiagnostic aids and management practice for feline retrovirus and coronavirus infections Cats, coronaviruses and coronavirus antibody tests Experimental inoculation of cats with canine coronavirus and subsequent challenge with feline infectious peritonitis virus Genomic organization of a virulent isolate of porcine transmissible gastroenteritis virus cDNA cloning and sequence analysis of the gene encoding the peplomer protein of feline infectious peritonitis virus lntracellular RNAs of the feline infectious peritonitis coronavirus strain 79-1146 Sequence analysis of the 3' end of the feline coronavirus FIPV 79-1146 genome: Comparison with the genome of porcine coronavirus TGEV reveals large insertion Characterization of a feline infectious peritonitis virus isolate Biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah Feline infectious peritonitis: A worldwide serosurvey Feline infectious peritonitis virus Antigenic relationships among homologous StlUClural polypeptides of porcine, feline and canine coronaviruses Isolation of feline coronaviruses from two cats with diverse disease manifestations A fast and sensitive method for detecting specific viral RNA in mammalian cells Morphologic and physical characteristics of feline infectious peritonitis virus and its growth in autochthonous peritoneal cell cultures Virologic and immunologic aspects of feline infectious peritonitis virus infection Coronavirus diseases (coronavirus enteritis, feline infectious peritonitis) Attempted immunization of cats against feline infectious peritonitis, using avirulent live virus or sublethal amounts of virulent virus Experimental studies with three new strains of feline infectious peritonitis virus: FIPV-UCD2, FIPV-UCD3 and FIPV-UCD4 Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683 The biology of coronaviruses Immunoehemistry of viruses, 1I. The basis for serodiagnosis and vaccines Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence Antigenic and biological diversity of feline coronaviruses: feline infectious peritonitis and feline enteritis virus Primary structure of the membrane and nucleocapsid protein genes of feline infectious peritonitis virus and immunogenicity of recombinant vaccinia viruses in kittens Pathogenesis of feline infectious peritonitis: Veterinary Microbiology DOI: 10.1016/0378-1135(93)90016-z sha: doc_id: 300489 cord_uid: gzcb6uqw Abstract A dot blot hybridization assay, using a biotinylated cDNA probe, was able to detect feline infectious peritonitis virus (FIPV) RNA in Felis catus whole fetus (fcwf-4) cells infected with the FIPV isolates DF2, 79-1146, UCDI, and UCD2.


id: cord-293565-420thmsr
author: Chang, Hui-Wen
title: Spike Protein Fusion Peptide and Feline Coronavirus Virulence
date: 2012-07-17
extension: .txt
mime: text/plain
words: 3768
sentence: 143
flesch: 41
cache: cache/cord-293565-420thmsr.txt
txt: txt/cord-293565-420thmsr.txt
summary:
  Coronaviruses post-SARS: update on replication and pathogenesis Coronavirus pathogenesis Porcine respiratory coronavirus: molecular features and virus-host interactions Sequence comparison of porcine respiratory coronavirus isolates reveals heterogeneity in the S, 3, and 3-1 genes Genetics and pathogenesis of feline infectious peritonitis virus Genetic determinants of pathogenesis by feline infectious peritonitis virus Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Signifi cance of coronavirus mutants in diseased tissues of cats suffering from feline infectious peritonitis Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats Common virus infections in cats, before and after being placed in shelters, with emphasis on feline enteric coronavirus Pathogenesis of feline enteric coronavirus infection A review of feline infectious peritonitis virus infection: 1963-2008 Sites of feline coronavirus persistence in healthy cats Persistence and evolution of feline coronavirus in a closed cat-breeding colony Pathogenic characteristics of persistent feline enteric coronavirus infection in cats Alazawy A. Diagnostic methods for feline coronavirus: a review The molecular genetics of feline coronaviruses: comparative sequence analysis of the ORF7a/7b transcription unit of different biotypes Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein Mutation of neutralizing/antibody-dependent enhancing epitope on spike protein and 7b gene of feline infectious peritonitis virus: infl uences of viral replication in monocytes/macrophages and virulence in cats Detection of feline coronavirus RNA in feces, tissues, and body fl uids of naturally infected cats by reverse transcriptase PCR Persistence and transmission of natural type I feline coronavirus infection The paradox of feline coronavirus pathogenesis: a review Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence FIPVs, feline infectious peritonitis viruses; FECVs, feline enteric coronaviruses.


id: cord-276617-chgjpg0v
author: Takano, Tomomi
date: 2008-11-30
extension: .txt
mime: text/plain
words: 3982
sentence: 163
flesch: 44
cache: cache/cord-276617-chgjpg0v.txt
txt: txt/cord-276617-chgjpg0v.txt
title:
  B-cell activation in cats with feline infectious peritonitis (FIP) by FIP-virus-induced B-cell differentiation/survival factors

summary:
  Moreover, increased levels of interleukin (IL)-6, a cytokine involved in the survival of B-cells and their differentiation into plasma cells, in ascites T. Takano Á N. Azuma Á Y. Hashida Á R. Satoh Á T. Hohdatsu (&) Laboratory of Veterinary Infectious Disease, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034-8628, Japan e-mail: hohdatsu@vmas.kitasato-u.ac.jp and culture supernatant of peritoneal exudative cells (PEC) from FIP cats have been reported [8] . Thus, the number of plasma cells may increase in the peripheral blood of FIP cats.


id: cord-333403-imx3990a
author: Christianson, K. K.
title: Characterization of a temperature sensitive feline infectious peritonitis coronavirus
date: 1989
extension: .txt
mime: text/plain
words: 4010
sentence: 188
flesch: 52
cache: cache/cord-333403-imx3990a.txt
txt: txt/cord-333403-imx3990a.txt
summary:
  Inconsistent protection was found when cats were given a sublethal dose of virulent FIPV and cats vaccinated with an avirulent FIPV were more easily infected than were nonvaccinated cats Feline infectious peritonitis (FIP) is a complex and fatal disease of cats caused by infection with feline infectious peritonitis virus (FIPV).


id: cord-311625-d7iycdyh
author: Choong, Oi Kuan
date: 2014-02-20
extension: .txt
mime: text/plain
words: 4024
sentence: 184
flesch: 48
cache: cache/cord-311625-d7iycdyh.txt
txt: txt/cord-311625-d7iycdyh.txt
title:
  In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication

summary:
  Both ends of the duplex TFOs were ligated with a linker sequence or clamps (C-C) to construct circular TFO RNA. One hundred nM of circular TFO RNA was transfected into MDCK cells.


id: cord-329642-5t8yuq4v
author: Takano, Tomomi
title: Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo
date: 2013-05-03
extension: .txt
mime: text/plain
words: 4264
sentence: 188
flesch: 52
cache: cache/cord-329642-5t8yuq4v.txt
txt: txt/cord-329642-5t8yuq4v.txt
summary:
  In contrast, no significant inhibitory effect was noted in cells with Post treatment, and the treatment of FIPV-infected monocytes collected from FIP cats with chloroquine did not change FIPV N gene expression, suggesting that the treatment of cells already infected with FIPV with chloroquine induces no antiviral effect. Focus on recent advancements Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease Disposition of chloroquine in man after single intravenous and oral doses Karnofsky's score modified for cats A study on the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection in feline macrophages by monoclonal antibodies Enhancement and neutralization of feline infectious peritonitis virus infection in feline macrophages by neutralizing monoclonal antibodies recognizing different epitopes Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus Chloroquine inhibits production of TNF-alpha, IL-1beta and IL-6 from lipopolysaccharide-stimulated human monocytes/macrophages by different modes Chloroquine inhibits proinflammatory cytokine release into human whole blood Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK A novel coronavirus associated with severe acute respiratory syndrome A randomized, double-blind, 24-week controlled study of low-dose cyclosporine versus chloroquine for early rheumatoid arthritis Effect of chloroquine phosphate treatment on serum MMP-9 and TIMP-1 levels in patients with systemic lupus erythematosus Human coronavirus EMC does not require the SARScoronavirus receptor and maintains broad replicative capability in mammalian cell lines Reduction of immune activation with chloroquine therapy during chronic HIV infection Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages Chloroquine administration does not prevent Nipah virus infection and disease in ferrets A review of feline infectious peritonitis virus infection: 1963-2008 Immunologic phenomena in the effusive form of feline infectious peritonitis Activation of p38 MAPK by feline infectious peritonitis virus regulates pro-inflammatory cytokine production in primary blood-derived feline mononuclear cells Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis Effects of chloroquine on viral infections: an old drug against today's diseases?


id: cord-271831-vekok62k
author: Dewerchin, H. L.
title: Replication of feline coronaviruses in peripheral blood monocytes
date: 2005-08-01
extension: .txt
mime: text/plain
words: 4709
sentence: 212
flesch: 50
cache: cache/cord-271831-vekok62k.txt
txt: txt/cord-271831-vekok62k.txt
summary:
  The percentage of FIPV infected cells with cytoplasmic expression increased till 24 hpi. Monocytes from the other 2 cats could initially be infected by both FIPV and FECV but FIPV infection was sustained in monocytes of only one cat. FECV-infection was never sustained and viral production was up to 100 times lower than in FIPV-infected monocytes.


id: cord-311982-wkg56xeq
author: Dye, Charlotte
title: Genomic RNA sequence of feline coronavirus strain FCoV C1Je
date: 2007-06-17
extension: .txt
mime: text/plain
words: 5243
sentence: 174
flesch: 46
cache: cache/cord-311982-wkg56xeq.txt
txt: txt/cord-311982-wkg56xeq.txt
summary:
  key: cord-311982-wkg56xeq authors: Dye, Charlotte; Siddell, Stuart G. title: Genomic RNA sequence of feline coronavirus strain FCoV C1Je date: 2007-06-17 journal: J Feline Med Surg DOI: 10.1016/j.jfms.2006.12.002 sha: doc_id: 311982 cord_uid: wkg56xeq Comparison of the FCoV C1Je genomic RNA sequence with that of the laboratory strain FCoV FIP virus (FIPV) 79-1146 showed that both viruses have a similar genome organisation and predictions made for the open reading frames and cis-acting elements of the FIPV 79-1146 genome hold true for FCoV C1Je.


id: cord-263165-bv4dh9eu
author: Möstl, Karin
title: Coronaviridae, pathogenetic and clinical aspects: An update
date: 1990-12-31
extension: .txt
mime: text/plain
words: 4907
sentence: 287
flesch: 43
cache: cache/cord-263165-bv4dh9eu.txt
txt: txt/cord-263165-bv4dh9eu.txt
summary:
  Special attention is paid to coronavirus infections of domestic cattle and pets, whereas avian, murine, rat and human coronaviruses are summarized briefly. ges Characterization of the virus of Sialodacryoadenitis of rats: a member of the coronavirus group An apparently new respiratory disease of baby chicks Electron microscopy of coronavirus-like particles characteristic of turkey bluecomb disease Seroepidemiologic studies of coronavirus infection in adults and children Coronavirus particles in faeces from patients with gastroenteritis Enteric coronaviruses in primates Coronavirus and gastroenteritis in foals Isolation of coronavirus-like agent from horses suffering from acute equine diarrhoea syndrome


id: cord-274673-tjzlssal
author: De Groot, Raoul J.
date: 1989-08-31
extension: .txt
mime: text/plain
words: 5151
sentence: 218
flesch: 51
cache: cache/cord-274673-tjzlssal.txt
txt: txt/cord-274673-tjzlssal.txt
title:
  Stably expressed FIPV peplomer protein induces cell fusion and elicits neutralizing antibodies in mice

summary:
  These results indicate that in RM(+)19 cells E2 is only slowly transported from ER to Golgi. Cell lines were established by isolating foci as described by Law et al.


id: cord-292570-618bt2vh
author: Shuid, Ahmad Naqib
title: Apoptosis transcriptional mechanism of feline infectious peritonitis virus infected cells
date: 2015-09-19
extension: .txt
mime: text/plain
words: 5661
sentence: 235
flesch: 43
cache: cache/cord-292570-618bt2vh.txt
txt: txt/cord-292570-618bt2vh.txt
summary:
  Hence, it can be concluded that increase of communalities of pro apoptotic genes at this time point lead to significant augmentation of the number of early apoptosis cells and depletion of the viable cells. Therefore, apoptosis T cell is probably caused by soluble mediators released from infection to macrophages and/or intestinal epithelial cells


id: cord-269986-jdcw59r2
author: Regan, Andrew D.
date: 2009-02-05
extension: .txt
mime: text/plain
words: 5535
sentence: 167
flesch: 38
cache: cache/cord-269986-jdcw59r2.txt
txt: txt/cord-269986-jdcw59r2.txt
title:
  Activation of p38 MAPK by feline infectious peritonitis virus regulates pro-inflammatory cytokine production in primary blood-derived feline mononuclear cells

summary:
  To investigate whether TNFalpha production in FIPV-infected PFBM cells is regulated by p38 MAPK activation, PFBM cells were treated with 10 μM of either SB 203580, SC 409 or 0.1% DMSO for 2 h before inoculating with FIPV-1146 or FIPV-DF2 at an MOI of 100. To determine whether or not FIPVinduced p38 MAPK activation was specific to a single animal, PFBM cells were individually prepared from six additional SPF cats (07PGP2, 07PGV4, 07PGV5, 07FGR2, 07FGV6, 07FJM5).


id: cord-312247-cza4qsv5
author: Würdinger, T
title: Targeting non-human coronaviruses to human cancer cells using a bispecific single-chain antibody
date: 2005-04-21
extension: .txt
mime: text/plain
words: 6619
sentence: 233
flesch: 41
cache: cache/cord-312247-cza4qsv5.txt
txt: txt/cord-312247-cza4qsv5.txt
summary:
  We found that the feline infectious peritonitis virus (FIPV) and a felinized murine hepatitis virus (fMHV), both normally incapable of infecting human cells, could rapidly and effectively kill human cancer cells artificially expressing the feline coronavirus receptor aminopeptidase N. Also 3-D multilayer tumor spheroids established from such cells were effectively eradicated. Subsequently, we investigated whether FIPV and fMHV could be targeted to human cancer cells expressing the epidermal growth factor receptor (EGFR), a molecule commonly overexpressed on many types of cancer cells 17 and associated with poor prognosis and response to cancer therapy.


id: cord-275225-fvq8hezk
author: Hornyák, Ákos
date: 2012-02-18
extension: .txt
mime: text/plain
words: 7145
sentence: 239
flesch: 42
cache: cache/cord-275225-fvq8hezk.txt
txt: txt/cord-275225-fvq8hezk.txt
title:
  Detection of subgenomic mRNA of feline coronavirus by real-time polymerase chain reaction based on primer-probe energy transfer (P-sg-QPCR)

summary:
  The prevalence of types I and II feline coronavirus infections in cats Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis Correlation of genomic detection of feline coronavirus with various diagnostic assays for feline infectious peritonitis Prevalence and genetic pattern of feline coronaviruses in urban cat populations Feline coronavirus serotypes 1 and 2: seroprevalence and association with disease in Switzerland FCoV shedding pattern of privately owned cats under field conditions Experimental studies with three new strains of feline infectious peritonitis virus: FIPV-UCD2, FIPV-UCD3, and FIPV-UCD4 Virologic and immunologic aspects of feline infectious peritonitis virus infection Development of a novel quantitative real-time RT-PCR assay for the simultaneous detection of all serotypes of foot-and-mouth disease virus Quantitative multiplex assay for simultaneous detection and identification of Indiana and New Jersey serotypes of vesicular stomatitis virus A simple method of estimating fifty percent endpoints Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein A mRNA PCR for the diagnosis of feline infectious peritonitis Isolation and identification of feline peritoneal macrophages for in vitro studies of coronavirus-macrophage interactions Taxonomic proposal of the Coronavirus Study Group to the ICTV Executive Committee Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease Evaluation of real-time RT-PCR for the quantification of FCoV shedding in the faeces of domestic cats SYBR Green real-time reverse transcription-polymerase chain reaction assay for the generic detection of coronaviruses Patterns of feline coronavirus infection and faecal shedding from cats in multiple-cat environments Zwischenmolekulare Energiewanderung und Fluoreszenz Discovery of novel human and animal cells infected by the severe acute respiratory syndrome coronavirus by replication-specific multiplex reverse transcription-PCR Development of a real-time PCR assay based on primer-probe energy transfer for the detection of swine vesicular disease virus The molecular genetics of feline coronaviruses: comparative sequence analysis of the ORF7a/7b transcription unit of different biotypes Persistence and evolution of feline coronavirus in a closed cat-breeding colony Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses A study on the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection in feline macrophages by monoclonal antibodies


id: cord-280621-tph5n7ak
author: Kim, Yunjeong
date: 2016-03-30
extension: .txt
mime: text/plain
words: 7435
sentence: 325
flesch: 50
cache: cache/cord-280621-tph5n7ak.txt
txt: txt/cord-280621-tph5n7ak.txt
title:
  Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

summary:
  These results on viral titers show that FIPV 3CLpro is a valid target for FIPV antiviral drugs and GC376 can effectively reduce the virus load in the macrophages from the ascites and the omentum of cats with FIP. This supportive treatment was discontinued before antiviral drug treatment commenced.


id: cord-325827-492xi3ee
author: Evermann, J. F.
date: 1988
extension: .txt
mime: text/plain
words: 4216
sentence: 152
flesch: 33
cache: cache/cord-325827-492xi3ee.txt
txt: txt/cord-325827-492xi3ee.txt
title:
  Biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah

summary:
  In: Holzworth J (ed) Diseases of the cat Infection studies in kittens using feline infectious peritonitis virus propagated in cell culture An enteric coronavirus infection of cats and relationship to feline infectious peritonitis Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683 Experimental studies with three new strains of feline infectious peritonitis virus: FIPV-UCD 2, FIPV-UCD 3 and FIPV-UCD 4 Eosinophilic ulcers in association with herpetic dermatitis in sibling cheetahs Feline infectious peritonitis in a captive cheetah Antibody-dependent enhancement of viral infectivity Infectious disease of nondomestic cats Experimentally induced coronavirus infections in calves: viral replication in the respiratory and intestinal tracts Dietary estrogen--a probable cause of infertility and liver disease in captive cheetahs Diagnosis of porcine and bovine enteric coronavirus infections using cloned cDNA probes The mutation rate and variability of eukaryotic viruses: an analytical review Intestinal, pulmonary, and serum antibody responses of feeder pigs exposed to transmissible gastroenteritis virus by the oral and the oralintranasal routes of inoculation Rapid evolution of RNA viruses Experimental studies of a coronavirus and coronavirus-like agent in a barrier-maintained feine breeding colony Proteolytic cleavage of the E 2 glycoprotein of murine coronavirus: activation of cell-fusing activity of virions by trypsin and separation of two different 90K cleavage fragments Role ofT cells in feline infectious peritonitis virus infection of suckling mice Trypsin-enhanced replication of neonatal calf diarrhea coronavirus in bovine embryonic lung cells Antigenic and biological diversity of feline coronaviruses: feline infectious peritonitis and feline enteritis virus Morphogenesis of a virus in cats with experimental feline infectiuos peritonitis Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever Pathogenesis of feline infectious peritonitis: nature and development of viremia Proteases involved in the processing of viral polyproteins Viral interference-dominance of mutant viruses over wild-type viruses in mixed infections Feline infectious peritonitis: review of gross and histopathologic lesions Lesions in the small intestine of newborn pigs inoculated with porcine, feline and canine coronaviruses Feline coronavirus. key: cord-325827-492xi3ee authors: Evermann, J. F.; Heeney, J. L.; Roelke, M. E.; McKeirnan, A. J.; O'Brien, S. J. title: Biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah date: 1988 journal: Arch Virol DOI: 10.1007/bf01310822 sha: doc_id: 325827 cord_uid: 492xi3ee


id: cord-336639-jaue41mv
author: Simons, Fermin A.
title: A mRNA PCR for the diagnosis of feline infectious peritonitis
date: 2004-12-21
extension: .txt
mime: text/plain
words: 3046
sentence: 114
flesch: 48
cache: cache/cord-336639-jaue41mv.txt
txt: txt/cord-336639-jaue41mv.txt
summary:
  Proteins of plasma and ascitic fluid Detection of feline coronaviruses by culture and reverse transcriptase-polymerase chain reaction of blood samples from healthy cats and cats with clinical feline infectious peritonitis Detection of feline coronavirus RNA in feces, tissues, and body fluids of naturally infected cats by reverse transcriptase PCR Elimination of feline coronavirus infection from a large experimental specific pathogen-free catbreeding colony by serologic testing and isolation The prevalence of type I and II feline coronavirus infections in cats Some important disorders of cats The virology and pathogenesis of felineinfectious peritonitis Sequence analysis of the porcine transmissible gastroenteritis coronavirus nucleocapsid protein gene Histopathological alterations of lymphatic tissues in cats without feline infectious peritonitis after long-term exposure to FIP virus The molecular biology of coronaviruses Isolation of Feline Coronaviruses from two cats with divers disease manifestations High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats Feline infectious peritonitis: Isolation of a coronavirus Feline Infectious Peritonitis (FIP) virus; propagation in suckling rat and hamster brain Virologic and immunologic aspects of feline infectious peritonitis virus infection Infection studies in kittens, using feline infectious peritonitis virus propagated in cell culture An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis Experimental studies with three new strains of feline infectious peritonitis virus: FIPV-UCD2, FIPV-UCD3, and FIPV-UCD4. Although the percentage of PCR-positive healthy animals is much lower when compared to FIP cats, a positive PCR result alone does not allow a definite diagnosis Gunn-Moore et al., 1998 ).


id: cord-330554-xg49foch
author: Tanaka, Yoshikazu
title: Suppression of feline coronavirus replication in vitro by cyclosporin A
date: 2012-04-30
extension: .txt
mime: text/plain
words: 3096
sentence: 121
flesch: 39
cache: cache/cord-330554-xg49foch.txt
txt: txt/cord-330554-xg49foch.txt
summary:
  These findings show that CsA does not influence the NF-AT pathway in fcwf-4 cells and that the inhibition of FIPV RNA replication by CsA is independent of the calcineurin NF-AT pathway. Consequently, the action of CsA on intracellular FIPV replication does not involve the activation of interferonstimulated genes on fcwf-4 cells.


id: cord-291858-e0s3o2r4
author: Tekes, G.
title: Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis
date: 2016-08-31
extension: .txt
mime: text/plain
words: 9237
sentence: 288
flesch: 35
cache: cache/cord-291858-e0s3o2r4.txt
txt: txt/cord-291858-e0s3o2r4.txt
summary:
  However, FECVs can occasionally induce severe enteritis (Kipar et al., 1998b) . To investigate the course of infection in more detail, FECV infection experiments have also been performed under controlled conditions (Desmarets et al., 2016; Kipar et al., 2010; Pedersen et al., 2008; Vogel et al., 2010) .


id: cord-349800-s9w2yr08
author: Hohdatsu, T.
date: 1991
extension: .txt
mime: text/plain
words: 3080
sentence: 124
flesch: 52
cache: cache/cord-349800-s9w2yr08.txt
txt: txt/cord-349800-s9w2yr08.txt
title:
  Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses

summary:
  key: cord-349800-s9w2yr08 authors: Hohdatsu, T.; Okada, S.; Koyama, H. title: Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses date: 1991 journal: Arch Virol DOI: 10.1007/bf01310494 sha: doc_id: 349800 cord_uid: s9w2yr08 Seven monoclonal antibodies (MAbs) with neutralizing activity against feline infectious peritonitis virus (FIPV) strain 79-1149 (type II) were prepared. The second antigenic group consists of human respiratory coronavirus HCV-229E, transmissible gastroenteritis virus (TGEV) of swine, canine coronavirus (CCV), and feline infectious peritonitis virus (FIPV)


id: cord-349964-38rgcc5h
author: Pedersen, N. C.
title: Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species
date: 1978
extension: .txt
mime: text/plain
words: 3024
sentence: 136
flesch: 47
cache: cache/cord-349964-38rgcc5h.txt
txt: txt/cord-349964-38rgcc5h.txt
summary:
  Zbl Antigenic relationship between human corona virus strain 0C 43 and hemagglutinating encephalomyelitis virus strain 67N of swine: antibody responses in human and animal sera I~ecovery in tracheal organ cultures of novel viruses from patients with respiratory disease Antigenic relationship among the coronaviruses of man and between human and animal coronaviruses Detection of eoronavirus infection of man by immunofluorescence Seroepidemiology of feline infectious peritonitis virus infections using transmissible gastroenteritis virus as antigen Rat corona virus (RCV) : a prevalent, naturally occurring pneumotropic virus of rats Serologic studies of naturally occurring feline infectious peritonitis Morphologic and physical characteristics of feline infectious peritonitis virus and its growth in autochthonous peritoneal ceil cultures Feline infectious peritonitis: something old, something new Characteristics of a coronavirus causing vomition and wasting in pigs Detection of transmissible gastroenteritis virus neutralizing antibody in cats Characterization of a calf diarrheal coronavirus Characterization of a calf diarrheal coronavirus Morphology-of transmissible gastroenteritis virus of pigs Morphogenesis of a virus in cats with experimental feline infectious peritonitis Untersuchungen fiber die Antigenverwandtschaft der Viren der Felinen infekti6ser Peritonitis und der transmissiblen Gastroenteritis des Sehweines Ultrastruetural evidence for the viral etiology of feline infectious peritonitis Received October 23, 1977 A possible antigenic relationship between feline infectious peritonitis virus (FIPV) and the transmissible gastroenteritis virus (TGEV) of swine has been recently reported (13, 19, 25) , which further supports the assumption t h a t


id: cord-355051-w18ptl0n
author: Satoh, Ryoichi
date: 2010-11-23
extension: .txt
mime: text/plain
words: 3254
sentence: 109
flesch: 42
cache: cache/cord-355051-w18ptl0n.txt
txt: txt/cord-355051-w18ptl0n.txt
title:
  Characterization of T helper (Th)1‐ and Th2‐type immune responses caused by baculovirus‐expressed protein derived from the S2 domain of feline infectious peritonitis virus, and exploration of the Th1 and Th2 epitopes in a mouse model

summary:
  The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination Virus entry: molecular mechanisms and biomedical applications Localization of antigenic sites of the S glycoprotein of feline infectious peritonitis virus involved in neutralization and antibody-dependent enhancement Monoclonal antibody analysis of neutralization and antibody-dependent enhancement of feline infectious peritonitis virus A study of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection in feline macrophages by monoclonal antibodies Enhancement and neutralization of feline infectious peritonitis virus infection in feline macrophages by neutralizing monoclonal antibodies recognizing different epitopes Antibody-dependent enhancement of feline infectious peritonitis virus infection in feline alveolar macrophages and human monocyte cell line U937 by serum of cats experimentally or naturally infected with feline coronavirus Selection of antigenic variants of the S glycoprotein of feline infectious peritonitis virus and analysis of antigenic sites involved in neutralization Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibody-dependent enhancement of infection of feline macrophages Vaccination of mice with recombinant baculovirus expressing spike or nucleocapsid protein of SARS-like coronavirus generates humoral and cellular immune responses Response of memory CD8 + T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals HLA-A * 0201 T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus nucleocapsid and spike proteins Identification of an HLA-A * 0201-restricted CD8 + T-cell epitope SSp-1 of SARS-CoV spike protein T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS Screening and identification of severe acute respiratory syndrome-associated coronavirus-specific CTL epitopes A transmissible gastroenteritis coronavirus nucleoprotein epitope elicits T helper cells that collaborate in the in vitro antibody synthesis to the three major structural viral proteins Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus Amino acid sequences predicted by the National Institute of Health (http://www-bimas.cit.nih.gov/molbio/ hla bind/) to have a strong capacity to bind to HLA-A24, were explored in the FP, HR1, and HR2 regions. Experimental inoculation of cats with canine coronavirus and subsequent challenge with feline infectious peritonitis virus A review of feline infectious peritonitis virus infection: 1963-2008 Attempted immunization of cats against feline infectious peritonitis, using avirulent live virus or sublethal amounts of virulent virus An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683 Attempted immunisation of cats against feline infectious peritonitis using canine coronavirus Cross-protection studies between feline infectious peritonitis and porcine transmissible gastroenteritis viruses Immunologic phenomena in the effusive form of feline infectious peritonitis Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever


id: cord-346321-drhiqch0
author: Hohdatsu, T.
date: 1994
extension: .txt
mime: text/plain
words: 3733
sentence: 128
flesch: 47
cache: cache/cord-346321-drhiqch0.txt
txt: txt/cord-346321-drhiqch0.txt
title:
  The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages

summary:
  key: cord-346321-drhiqch0 authors: Hohdatsu, T.; Tokunaga, J.; Koyama, H. title: The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages date: 1994 journal: Arch Virol DOI: 10.1007/bf01310791 sha: doc_id: 346321 cord_uid: drhiqch0 Antibody-dependent enhancement (ADE) of feline infectious peritonitis virus (FIPV) infection was studied in feline alveolar macrophages and human monocyte cell line U937 using mouse neutralizing monoclonal antibodies (MAbs) directed to the spike protein of FIPV. I. Infection enhancement by nonneutralizing antibody Heterogeneity of infection enhancement of dengue 2 strains by monoclonal antibodies Characterization of monoelonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine and canine coronaviruses A study on the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection in feline macrophages by monoctonal antibodies Enhancement and neutralization of feline infectious peritonitis virus infection in feline macrophages by neutralizing monoclonal antibodies recognizing different epitopes Studies on the mechanism of antibody-mediated enhancement of Getah virus infectivity Human monocytes and U937 cells bear two distinct Fc receptors for IgG Neuraminidase augments Fc y receptor II-mediated antibody-dependent enhancement of dengue virus infection Dengue 4 virus monoctonal antibodies identify epitopes that mediate immune infection enhancement of dengue 2 viruses Antibody-mediated growth of influenza A NWS virus in macrophagelike cell line P388D1 Identification of antigenic sites mediating antibody-dependent enhancement of feline infectious peritonitis virus infectivity Monoclonal antibodies to the spike protein of feline infectious peritonitis virus mediate antibodydependent enhancement of infection of feline macrophages Attempted immunization of cats against feline infectious peritonitis, using avirulent live virus or sublethal amounts of virulent virus Immunologic phenomena in the effusive form of feline infectious peritonitis Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683 An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis Virologic and immunologic aspects of feline infectious peritonitis virus infection Antibody-mediated enhancement of flavivirus replication in macrophage-like cell lines Growth of 17 D yellow fever virus in a macrophage-like cell line, U937: role of Fc and viral receptors in antibody-mediated infection Feline immunoglobulins Attempted immunisation of cats against feline infectious peritonitis using canine coronavirus The sites of early viral replication in feline infectious peritonitis Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry Function and heterogeneity of human Fc receptors for immunoglobulin G Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever Cross-protection studies between feline infectious peritonitis and porcine transmissible gastroenteritis viruses This work was supported by private contributions of Sankyo Co., Ltd., Ajinomoto General Foods, Inc. and Dainippon Pharmaceutical Co., Ltd., Japan.


id: cord-345863-j01l71dh
author: Drechsler, Yvonne
title: Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection
date: 2020-06-09
extension: .txt
mime: text/plain
words: 5533
sentence: 199
flesch: 36
cache: cache/cord-345863-j01l71dh.txt
txt: txt/cord-345863-j01l71dh.txt
summary:
  A study of naturally occurring feline coronavirus infections in kittens Serologic studies of naturally occurring feline infectious peritonitis Risk factors for feline coronavirus seropositivity in cats relinquished to a UK rescue charity Feline coronavirus in multicat environments An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis Risk factors for feline infectious peritonitis among cats in multiple-cat environments with endemic feline enteric coronavirus Feline Infectious Peritonitis Replication of feline coronaviruses in peripheral blood monocytes Sites of feline coronavirus persistence in healthy cats Pathogenic characteristics of persistent feline enteric coronavirus infection in cats Feline infectious peritonitis: Role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats Prevalence of feline infectious peritonitis in specific cat breeds Clinicopathological findings associated with feline infectious peritonitis in Clinicopathological findings and disease staging of feline infectious peritonitis: 51 cases from 2003 to 2009 in Taiwan Preliminary studies on feline coronavirus distribution in naturally and experimentally infected cats An overview of feline enteric coronavirus and infectious peritonitis virus infections Antibody-dependent enhancement of serotype II feline enteric coronavirus infection in primary feline monocytes Antibody-dependent enhancement of feline infectious peritonitis virus infection in feline alveolar macrophages and human monocyte cell line U937 by serum of cats experimentally or naturally infected with feline coronavirus A possible involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis Natural feline coronavirus infection: Differences in cytokine patterns in association with the outcome of infection In vivo cytokine response to experimental feline infectious peritonitis virus infection Disease outcome and cytokine responses in cats immunized with an avirulent feline infectious peritonitis virus (FIPV)-UCD1 and challenge-exposed with virulent FIPV-UCD8 Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease Apoptosis and T-cell depletion during feline infectious peritonitis Transcriptome analysis of feline infectious peritonitis virus infection Transcriptional profiling of feline infectious peritonitis virus infection in CRFK cells and in PBMCs from FIP diagnosed cats Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq A rapid and simple method to obtain canine peripheral blood-derived macrophages Trimmomatic: A flexible trimmer for Illumina sequence data Near-optimal probabilistic RNA-seq quantification Data quality aware analysis of differential expression in RNA-seq with NOISeq R/Bioc package limma powers differential expression analyses for RNA-sequencing and microarray studies ClueGO: Therefore, macrophage gene expression from cats #1, 2, and 5 was compared.


id: cord-299976-36r794ow
author: O’Brien, Amornrat
date: 2018-12-01
extension: .txt
mime: text/plain
words: 6082
sentence: 180
flesch: 42
cache: cache/cord-299976-36r794ow.txt
txt: txt/cord-299976-36r794ow.txt
title:
  Characterizing replication kinetics and plaque production of type I feline infectious peritonitis virus in three feline cell lines

summary:
  We show that Fcwf-4 CU cells are less responsive to exogenous type I interferon than Fcwf-4 cells from the ATCC and are permissive to infection by both biotypes of type II FCoV. To facilitate Cell-free titer was determined from cell-clarified supernatants; cell-associated titer was determined from suspended cell monolayers following three freeze-thaw cycles alternating between −80°C and 37 o C. Samples were taken at hours post-infection (hpi) just prior to, at, and following the maximum (max) virus titer for each cell type. Type I FIPV Black and both biotypes of type II FCoV formed uniform and enumerable plaques on Fcwf-4 CU cells.


id: cord-309205-l8vjtrjq
author: Shirato, Kazuya
date: 2018-08-15
extension: .txt
mime: text/plain
words: 6696
sentence: 206
flesch: 38
cache: cache/cord-309205-l8vjtrjq.txt
txt: txt/cord-309205-l8vjtrjq.txt
title:
  Differential susceptibility of macrophages to serotype II feline coronaviruses correlates with differences in the viral spike protein

summary:
  The prevalence of types I and II feline coronavirus infections in cats Protease-mediated entry via the endosome of human coronavirus 229E Deletions in the 7a ORF of feline coronavirus associated with an epidemic of feline infectious peritonitis Feline infectious peritonitis: still an enigma? Sites of feline coronavirus persistence in healthy cats Feline coronavirus serotypes 1 and 2: seroprevalence and association with disease in Switzerland Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier Cellular entry of the porcine epidemic diarrhea virus Mutation in spike protein cleavage site and pathogenesis of feline coronavirus Field strain feline coronaviruses with small deletions in ORF7b associated with both enteric infection and feline infectious peritonitis Genetic diversity and correlation with feline infectious peritonitis of feline coronavirus type I and II: a 5-year study in Taiwan Discrepancies between feline coronavirus antibody and nucleic acid detection in effusions of cats with suspected feline infectious peritonitis Isolation of feline coronaviruses from two cats with diverse disease manifestations Host cell proteases: critical determinants of coronavirus tropism and pathogenesis The paradox of feline coronavirus pathogenesis: a review Receptor-bound porcine epidemic diarrhea virus spike protein cleaved by trypsin induces membrane fusion A review of feline infectious peritonitis virus infection: 1963-2008 An update on feline infectious peritonitis: virology and immunopathogenesis Pathogenic differences between various feline coronavirus isolates Pathogenicity studies of feline coronavirus isolates 79-1146 and 79-1683 Pathogenesis of feline enteric coronavirus infection Pathogenesis of feline enteric coronavirus infection Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis Utilization of DC-SIGN for entry of feline coronaviruses into host cells Differential role for low pH and cathepsin-mediated cleavage of the viral spike protein during entry of serotype II feline coronaviruses Feline lectin activity is critical for the cellular entry of feline infectious peritonitis virus Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein Clinical isolates of human coronavirus 229E bypass the endosome for cell entry Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes Genetic drift and genetic shift during feline coronavirus evolution Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Pathogenic characteristics of persistent feline enteric coronavirus infection in cats Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture Several genes, including the S gene and the accessory genes 3a, 3b, 3c, 7a, and 7b, have been considered (Balint et al., 2012; Chang et al., 2010; Kennedy et al., 2001; Licitra et al., 2013; Pedersen et al., 2012; Rottier et al., 2005; Vennema et al., 1998) .


id: cord-356112-c32icxir
author: Weiss, R. C.
date: 1988
extension: .txt
mime: text/plain
words: 4028
sentence: 164
flesch: 41
cache: cache/cord-356112-c32icxir.txt
txt: txt/cord-356112-c32icxir.txt
title:
  Increased plasma levels of leukotriene B4 and prostaglandin E2 in cats experimentally inoculated with feline infectious peritonitis virus

summary:
  Significant increases (P<0.05) in PGE2 plasma levels occurred in 80% (4/5) of FIPV-infected kittens on PCD 7 and 14. Significant increases (PcO.05) in PGE2 plasma levels occurred in 80% (4/5) of FIPV-infected kittens on PCD 7 and 14.


id: cord-323805-9n63ms3c
author: Pedersen, Niels C.
date: 2014-11-15
extension: .txt
mime: text/plain
words: 5751
sentence: 213
flesch: 43
cache: cache/cord-323805-9n63ms3c.txt
txt: txt/cord-323805-9n63ms3c.txt
title:
  The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis

summary:
  Cats from family A were sired by multiple related cats while cats in families B and C were each descended from a single sire. Foley et al. (1997) studied a number of environmental risk factors for FIP in seven catteries and found that cat numbers (density) and husbandry procedures had no influence on FIP incidence while age, high coronavirus antibody titers, and the proportion of cats shedding coronavirus were significantly associated with FIP risk.


id: cord-348204-365z3qxz
author: Harun, Mohammad Syamsul Reza
date: 2013-11-09
extension: .txt
mime: text/plain
words: 4693
sentence: 179
flesch: 46
cache: cache/cord-348204-365z3qxz.txt
txt: txt/cord-348204-365z3qxz.txt
title:
  Transcriptional profiling of feline infectious peritonitis virus infection in CRFK cells and in PBMCs from FIP diagnosed cats

summary:
  Prevalence of feline coronavirus in two cat populations in Malaysia A review of feline infectious peritonitis virus infection: 1963-2008 Feline infectious peritonitis The molecular genetics of feline coronaviruses: comparative sequence analysis of the ORF7a/7b transcription unit of different biotypes Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Mutation in spike protein cleavage site and pathogenesis of feline coronavirus Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease Apoptosis and T-cell depletion during feline infectious peritonitis A possible involvement of TNF-alpha in apoptosis induction in peripheral blood lymphocytes of cats with feline infectious peritonitis Kinetic analysis of a complete poxvirus transcriptome an immediate early class of gene Hepatic transcriptome analysis of hepatitis C virus infection in chimpanzees defines unique gene expression patterns associated with viral clearance Gene-expression changes induced by Feline immunodeficiency virus infection differ in epithelial cells and lymphocytes Viral transcriptome analysis of feline immunodeficiency virus infected cells using second generation sequencing technology A greedy algorithm for aligning DNA sequences Attachment and internalization of feline infectious peritonitis virus in feline blood monocytes and Crandell feline kidney cells Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources Functions, structure, and read-through alternative splicing of feline APOBEC3 genes Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were associated with impaired dendritic cells function in HCV infection Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity Reduced APOBEC3H variant antiviral activities are associated with altered RNA binding activities Feline programmed death and its ligand: characterization and changes with feline immunodeficiency virus infection Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction PD-1 and its ligands in tolerance and immunity Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production Regulation of cysteine-rich intestinal protein, a zinc finger protein, by mediators of the immune response Cellular composition and interferon-γ expression of the local inflammatory response in feline infectious peritonitis (FIP) Replication of feline coronaviruses in peripheral blood monocytes Andes virus stimulates interferon-inducible MxA protein expression in endothelial cells West Nile virusinduced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector The neutrophil serine protease inhibitor SerpinB1 protects against inflammatory lung injury and morbidity in influenza virus infection SerpinB1 protects the mature neutrophil reserve in the bone marrow Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis The UCSC felCat4 data from the Dec. 2008 catChrV17e draft assembly Mapping and quantifying mammalian transcriptomes by RNA-Seq Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Based on Kal’s Z-test, with False Discovery Rate (FDR) <0.05 and >1.99 fold change on gene expressions, a total of 61 genes were differentially expressed by both samples, where 44 genes were up-regulated and the remainder were down-regulated.


id: cord-351955-9l4786lb
author: Pedersen, Niels C.
date: 2009-08-26
extension: .txt
mime: text/plain
words: 6791
sentence: 277
flesch: 54
cache: cache/cord-351955-9l4786lb.txt
txt: txt/cord-351955-9l4786lb.txt
title:
  Significance of Coronavirus Mutants in Feces and Diseased Tissues of Cats Suffering from Feline Infectious Peritonitis

summary:
  There is also evidence that FIPV may have been shed in urine of FIPV infected cats [35] , and that coronavirus may be present in the blood, especially among younger cats [36] . As with the earlier study [17] , all or almost all of the fecal isolates from diseased cats and a healthy contact control animal had intact 3c genes.


id: cord-283132-rfw8njpo
author: Olsen, Christopher W.
date: 1993-07-31
extension: .txt
mime: text/plain
words: 13951
sentence: 424
flesch: 29
cache: cache/cord-283132-rfw8njpo.txt
txt: txt/cord-283132-rfw8njpo.txt
title:
  A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination

summary:
  The data presented by Scott et al. indicate that the ability of the vaccine to protect cats against experimental challenge is dependent upon the strain and particularly the dose of challenge virus. Similar correlations between host resistance to virus infection in vivo and intrinsic resistance (Morahan, et al., 1985 ) ofmacrophages to infection in vitro have been documented for several other virus families (Mogensen, 1985) .


id: cord-312006-c08u4t16
author: Pedersen, Niels C.
title: An update on feline infectious peritonitis: Virology and immunopathogenesis
date: 2014-05-01
extension: .txt
mime: text/plain
words: 10549
sentence: 367
flesch: 44
cache: cache/cord-312006-c08u4t16.txt
txt: txt/cord-312006-c08u4t16.txt
summary:
  Influences of viral replication in monocytes/macrophages and virulence in cats Evaluation of protective efficacy of the synthetic peptide vaccine containing the T helper 1 epitope with CpG oligodeoxynucleotide against feline infectious peritonitis virus infection in cats Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in spike 1 domain and membrane protein of feline infectious peritonitis virus Novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis Genome organization and reverse genetic analysis of a type I feline coronavirus Chimeric feline coronaviruses that encode type II spike protein on type I genetic background display accelerated viral growth and altered receptor usage A reverse genetics approach to study feline infectious peritonitis Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats Clathrin-and caveolae-independent entry of feline infectious peritonitis virus in monocytes depends on dynamin Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses Loss of virulence associated with ORF 7b mutations in FIPVs has also led to false assumptions regarding the importance of this ORF in FECV-to-FIPV conversion and the designation of feline coronavirus strain WSU-79-1683 as a prototypic FECV, which was originally based on cat infection studies comparing type II WSU-79-1683, which does not cause FIP, with WSU-79-1146, the prototypic type II FIPV (Pedersen et al., 1984) .


# ent

id: cord-263165-bv4dh9eu
sid: 260
eid: 1
type: PRODUCT
entity:
  un cas de pneumonie chez des bovins chliche beteiligung boviner coronaviren an respiratorischen krankheitsausbrfichen bei kfilbern und pathogenetisch-immunologische


