item: #1 of 43 id: cord-000425-isw6jeir author: Flori, Laurence title: Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation date: 2011-07-29 words: 7843 flesch: 40 summary: This cluster is representative of total cell number traits despite the eosinophil count (EOS) not being included. The estimation of phenotypic correlations (r r p ) with WOMBAT confirmed that the ITs are weakly correlated, except i) among a few cell count traits (WBC, LYM, MON, NEU), and ii) between cell count traits and a few leukocyte subsets (WBC, LYM, CD16 + CD2 + and keywords: adaptive; blood; cd16; cell; correlations; france; heritability; immunity; lps; pigs; production; response; subsets; total; traits cache: cord-000425-isw6jeir.txt plain text: cord-000425-isw6jeir.txt item: #2 of 43 id: cord-004534-jqm1hxps author: None title: Abstract date: 2009-06-09 words: 139178 flesch: 39 summary: This simple model illustrates how differential detergent selectivity for faces and strong constraints coming from purely environmental features could influence transmembrane helix packing, membrane protein structure and assembly. Imaging of mobile stable lipid rafts in the live cell plasma membrane M. Brameshuber 1 , J. Weghuber 1 , V. Ruprecht 1 , H. Stockinger 2 , G. J. Schuetz 1 1 Johannes Kepler University Linz, Austria, 2 Medical University of Vienna, Austria The organization of the cellular plasma membrane at a nanoscopic length scale is believed to affect the association of distinct sets of membrane proteins for the regulation of multiple signaling pathways. keywords: acid; actin; activation; activity; addition; affinity; afm; aggregates; aggregation; amyloid; analysis; applications; approach; assembly; atomic; atp; behavior; bilayer; binding; biological; biology; biophysics; brain; calcium; cancer; cell; cell membrane; cell surface; center; chain; changes; channel; characterization; charge; chemical; chemistry; cholesterol; combination; complex; complexes; concentration; conditions; confocal; conformational; constant; contrast; control; correlation; cross; current; data; decrease; delivery; density; department; design; detection; development; diffusion; disease; distribution; dna; domain; drug; dynamics; effect; electron; emission; energy; environment; enzyme; excitation; experiments; expression; fibrils; field; flow; fluorescence; fluorescence microscopy; fluorescent protein; force; force microscopy; formation; france; free; fret; function; gene; genova; germany; group; growth; helix; human; imaging; increase; influence; institute; intensity; interaction; intracellular; italy; key; kinetics; laser; length; level; lifetime; ligand; light; lipid; lipid membranes; liposomes; living; measurements; mechanism; membrane; membrane protein; membrane surface; method; microscopy; model; model membrane; molecular; molecules; muscle; mutant; nanoparticles; neuronal; neurons; new; non; novel; number; order; parameters; particles; peptide; phase; physical; physics; plasma membrane; pore; potential; presence; present; probe; process; processes; properties; protein; protein complexes; protein dynamics; protein interactions; protein structure; range; rate; ray; reaction; receptor; region; release; report; research; residues; resolution; response; results; rna; role; sample; scanning; scattering; sciences; second; self; sequence; signal; simulations; site; size; solvent; species; specific; spectroscopy; stability; state; step; structure; studies; study; surface; system; target; techniques; temperature; terminal; time; transfer; transition; transmembrane; transport; treatment; type; understanding; unfolding; university; use; vesicles; virus; vitro; vivo; water; work cache: cord-004534-jqm1hxps.txt plain text: cord-004534-jqm1hxps.txt item: #3 of 43 id: cord-007890-bie1veti author: None title: ECC-4 Abstracts date: 2002-04-16 words: 86133 flesch: 45 summary: On the whole, E. coli showed an elevated sensitivity rate ( !/90% of tested strains) to nitrofurantoin, gentamicin, amikacin, and 2nd-and 3rd-generation cephalosporins, while only amoxicillin and piperacillin had a mean resistance rate !/30 % for M41L, D67N, K103N, M184V, L210W, T215YF, and for L10I, M36I, L63P, A71VT, L90M for P Inhibitors (PI). keywords: acid; activity; acute; administration; aeruginosa; agar; agents; aim; amoxicillin; analysis; antibiotic; antimicrobial; associated; aureus; b b; bacteria; beta; blood; candida; care; cases; cells; children; chronic; ciprofloxacin; clinical; coli; combination; concentrations; conclusion; control; cultures; data; days; department; diagnosis; disease; dna; dose; drug; effect; efficacy; erythromycin; esbl; fever; following; france; general; gentamicin; gram; group; haart; hcv; health; hepatitis; high; hiv; hospital; human; ifn; imipenem; incidence; infected; infection; influenza; institute; isolates; l b; laboratory; level; linezolid; mean; medical; medicine; methods; microbiology; mics; months; mrsa; nccls; negative; new; non; nosocomial; number; oral; patients; pcr; penicillin; period; plasma; pneumoniae; positive; presence; present; prevalence; pts; purpose; rate; resistance; results; risk; rna; samples; school; sensitivity; serum; spain; species; specific; spp; staphylococcus; strains; streptococcus; study; susceptibility; system; teicoplanin; tested; therapy; time; tissue; total; tract; treatment; university; urinary; urine; use; vancomycin; virus; vitro; years cache: cord-007890-bie1veti.txt plain text: cord-007890-bie1veti.txt item: #4 of 43 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61107 flesch: 45 summary: We included ICU patients admitted for acute hypoxemic respiratory failure from a previous prospective trial [1] in whom FiO 2 was measured under oxygen mask using a portable oxygen analyzer. Introduction Relative adrenal insufficiency (RAI) is common in ICU patients, particularly during septic shock (1). keywords: acute; admission; adult patients; age; aim; analysis; ards patients; arrest; blood; cardiac; care; care unit; cases; cause; children; clinical; conclusion; criteria; data; days; diagnosis; discussion; disease; duration; extubation; factors; failure; fluid; group; hospital; icu; icu admission; icu mortality; icu patients; incidence; infection; injury; intensive; introduction; jean; low; lung; management; mean; mechanical; median; medical; methods; mortality; n =; niv; non; nutrition; occurrence; outcome; oxygen; p =; patients; period; pierre; pneumonia; pressure; pulmonary; rate; renal; results; risk; score; sepsis; shock; shock patients; significant; stay; studies; study; study period; support; syndrome; therapy; time; treatment; unit; use; vap; ventilation; weaning; years cache: cord-014538-6a2pviol.txt plain text: cord-014538-6a2pviol.txt item: #5 of 43 id: cord-014685-ihh30q6f author: None title: Posters P788 - P999 date: 2005-09-21 words: 38408 flesch: 42 summary: 12 physical property parameters of protein structure were chosen to construct a 12-dimension physical property space. These systems have proven to be also valuable as membrane mimetic structures, as promising matrices for controlled-release and delivery of proteins, vitamins and small drugs in pharmacological applications, and they offer a 3D lipid matrix for successful crystallization of membrane proteins which do not easily crystallize in bulk solution. keywords: activity; aggregation; analysis; beta; binding; cells; changes; complex; complexes; concentration; conformational; data; delivery; dna; domain; drug; dynamics; effect; energy; experiments; folding; function; human; institute; interaction; light; lipid; loop; mechanism; membrane; membrane protein; method; model; molecular; native; new; nmr; order; peptide; phase; potential; presence; process; properties; protein; protein structure; region; residues; results; rna; rst; sequence; signi; site; solution; speci; stability; state; step; structure; studies; study; surface; system; temperature; terminal; time; transition; transport; type; unfolding; university; uorescence; water; work cache: cord-014685-ihh30q6f.txt plain text: cord-014685-ihh30q6f.txt item: #6 of 43 id: cord-015334-8p124rwp author: None title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 words: 51170 flesch: 47 summary: The main off-label indications were prevention of hemorrhagic risk of antiplatelet agent (23%), hemoglobin decrease(16%), anticoagulant co-prescription(13%), steroids co-prescription(6%). A rinse volume of 10 ml improved significantly the transit of Mopral Ò , Ogast Ò and Ogastoro Ò (+4.8%, keywords: administration; age; analysis; background; blood; care; cases; community; conclusions; control; criteria; data; days; department; design; disease; dosage; dose; drug; effects; errors; group; guidelines; health; hospital; information; interventions; level; management; mean; measures; medical; medication; months; new; non; number; nurses; objective; oral; order; outcome; outcome measures; pain; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; practice; prescriptions; problems; quality; questionnaire; recommendations; results; risk; safety; setting; studies; study; therapy; time; total; treatment; use; years cache: cord-015334-8p124rwp.txt plain text: cord-015334-8p124rwp.txt item: #7 of 43 id: cord-016095-jop2rx61 author: Vignais, Pierre V. title: Challenges for Experimentation on Living Beings at the Dawn of the 21(st) Century date: 2010-06-08 words: 42858 flesch: 42 summary: Nevertheless, research on such cells is mandatory if we wish to move on to a regenerative medicine that aims to be a new frontier in the art of healing. In Man, such cells could be directed by differentiation towards stable cell lines creating well-defined tissues and organs (liver, muscle…) that could be used in regenerative medicine. keywords: animal; atp; beings; biology; case; cells; century; chapter; cloning; dna; domain; enzyme; example; experiments; fact; figure; gene; genome; human; information; life; living; means; medicine; messenger; metabolic; method; molecular; molecules; neurons; non; order; plant; present; progress; proteins; research; rise; rnas; science; sequence; species; stem; stem cells; study; subject; synthesis; techniques; technology; time; type; use; way; years cache: cord-016095-jop2rx61.txt plain text: cord-016095-jop2rx61.txt item: #8 of 43 id: cord-021158-075vh5jg author: Fortané, Nicolas title: Antimicrobial resistance: preventive approaches to the rescue? Professional expertise and business model of French “industrial” veterinarians date: 2020-01-06 words: 12212 flesch: 48 summary: One of the most important concerns the controversies and public policies that have developed over recent years with regard to the issue of antimicrobial resistance (AMR), which has directly challenged the economic and professional model of farm animal veterinary practices that were setting drugs (mostly antibiotics) up as a cornerstone of veterinary activity, as a source of both income and professional expertise. The fact is that this model of preventive veterinary medicine seems in reality to be quite typical of a very particular segment of the veterinary profession, the one this article proposes to describe, namely industrial vets. keywords: amr; animal; antibiotics; approaches; expertise; farmers; health; medicine; model; pig; poultry; profession; time; use; veterinarians; veterinary; vets cache: cord-021158-075vh5jg.txt plain text: cord-021158-075vh5jg.txt item: #9 of 43 id: cord-023049-fio7cjj5 author: None title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 words: 145714 flesch: 46 summary: We compared the median SNAP with radial SNAP measured antidromically at digit 1 in GBS patients whose nerve conduction study showed the sural-sparing pattern. The aim of the present investigation is to summarize the current knowledge on sweating disturbances in GBS patients. keywords: 1,2; activity; acute; addition; age; aim; amyloid; analysis; anti; antibodies; antibody; associated; axonal; axons; barré; baseline; biopsy; blood; cases; cause; cells; center; changes; charcot; children; chronic; cidp patients; cmt patients; cmt1a; cohort; conduction study; control patients; controls; course; criteria; data; days; degeneration; demyelinating; department; development; diabetic; diagnosis; differences; disability; disease; dominant; dose; effect; examination; expression; f 1; family; findings; following; foot; france; function; g 1; gbs patients; gene; group; guillain; healthy; hospital; human; igg; impairment; improvement; increase; inflammatory; injury; institute; intravenous; involvement; ivig; j 1; k 1; levels; limbs; loss; mag; marie; mean; measures; median; medical; medicine; mice; model; months; motor; motor nerve; mouse; mri; muscle; mutations; ncs; negative; nerve; nerve conduction; nerve fibers; nerve injury; nerve regeneration; neurological; neurology; neurons; neuropathies; neuropathy; new; nf155; non; normal; novel; number; onset; outcome; pain; participants; patients; phenotype; placebo; pmp22; polyneuropathy; positive; potential; present; progression; protein; range; reduced; report; respectively; response; results; risk; role; scale; schwann; score; sensory; sequencing; serum; severe; severity; skin; strength; studies; study; subjects; sural; symptoms; syndrome; system; test; testing; therapeutic; therapy; time; tissue; tooth; total; treatment; ttr; type; ulnar; university; upper; usa; variants; weakness; weeks; y 1; years cache: cord-023049-fio7cjj5.txt plain text: cord-023049-fio7cjj5.txt item: #10 of 43 id: cord-252950-eiphxwmn author: Trouillet-Assant, Sophie title: Type I IFN immunoprofiling in COVID-19 patients date: 2020-04-29 words: 1558 flesch: 44 summary: Clinical features of patients infected with 114 2019 novel coronavirus in Wuhan, China COVID-19: 116 consider cytokine storm syndromes and immunosuppression TYPE I INTERFERONS (α/β) IN IMMUNITY 118 AND AUTOIMMUNITY /679 and Directive 95/46/EC) and the French data protection law (Law n°78-17 on 06/01/1978 and Décret n°2019-536 on 29/05/2019), we obtained consent from each patient or his next of kin USA) on plasma samples of COVID-19 patients. 61 In this study, we assessed the kinetics of plasma IFN-I in COVID-19 patients with a spectrum of 62 severity degree. keywords: covid-19; france; ifn; interferon; patients cache: cord-252950-eiphxwmn.txt plain text: cord-252950-eiphxwmn.txt item: #11 of 43 id: cord-253801-y1nherse author: Lepelletier, Didier title: Risque d’introduction et voies d’importation par l’homme de maladies infectieuses exotiques : cas particulier de l’émergence de bactéries pathogènes multirésistantes aux antibiotiques, importées en France à l’occasion de voyages internationaux ou du rapatriement de patients hospitalisés à l’étranger date: 2009-11-30 words: 2266 flesch: 38 summary: Toutefois, selon les spécificités locales de la pression de sélection et des modes de vie des populations, les niveaux de résistance ne sont pas égaux dans tous les pays. [28, 29] , mais d'autres cas ont été importés en provenance d'autres pays de la Communauté européenne, notamment de Grèce [30] . keywords: antibiotiques; aux; bactéries; dans; des; difficile; est; france; les; ont cache: cord-253801-y1nherse.txt plain text: cord-253801-y1nherse.txt item: #12 of 43 id: cord-257325-pvf0uon3 author: Zeitoun, Jean-David title: Impact of Local Care Environment and Social Characteristics on Aggregated Hospital-Fatality Rate from COVID-19 in France: Nationwide Observational Study date: 2020-10-10 words: 2373 flesch: 49 summary: Thirdly, we did not have access to hospital data or patient data. 4 Fatality rate, defined as the number of deaths of patients in whom COVID-19 was confirmed, divided by the total number of COVID-19 cases, seems to vary among countries. keywords: covid-19; fatality; hospital; rate cache: cord-257325-pvf0uon3.txt plain text: cord-257325-pvf0uon3.txt item: #13 of 43 id: cord-262046-bb8ekgdm author: Unlu, E. title: Epidemic analysis of COVID-19 Outbreak and Counter-Measures in France date: 2020-05-01 words: 2882 flesch: 48 summary: The gradual lockdown lift, starting on May 11, is modeled as a %5 to %10 increase of quarantine time reproduction number for each week for next 3 weeks (assuming reproduction number does nor grow after 3 weeks), presenting two different scenarii for France. An error metric based on the daily death toll is presented and model parameters are All rights reserved. keywords: covid-19; france; lockdown; model; number; seir cache: cord-262046-bb8ekgdm.txt plain text: cord-262046-bb8ekgdm.txt item: #14 of 43 id: cord-264203-7dnz9yaa author: Coldefy, Magali title: The geography of institutional psychiatric care in France 1800–2000: Historical analysis of the spatial diffusion of specialised facilities for institutional care of mental illness date: 2010-10-10 words: 11259 flesch: 36 summary: Empirical observations of innovation diffusion processes have systematically demonstrated that vertical diffusion down through the urban hierarchy has been dominant in a large number of diffusion processes, accompanied by 'horizontal', contagious diffusion around the larger centres (Pumain & Saint Julien, 2001) . This review of the processes influencing asylum diffusion through French national space suggests it can be viewed as an example of an innovation diffusion process in which the original innovation took place through an informal network of reformers, (which might have produced rather randomly distributed sites for the very first asylums), but that after 1838, the leading adopter was a collective (state) agent, operating through a highly structured geographical and administrative hierarchy. keywords: asylum; care; century; development; diffusion; diffusion process; départements; facilities; france; health; hospitals; innovation; institutions; model; new; process; psychiatric; urban cache: cord-264203-7dnz9yaa.txt plain text: cord-264203-7dnz9yaa.txt item: #15 of 43 id: cord-267867-q52nvn0n author: Chevalier, Christophe title: Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs date: 2016-12-14 words: 8023 flesch: 37 summary: The siRNAs si240-1a and si244 proved to be the most efficient inhibitors of HCV RNA replication with inhibition doses 50 of 19 ng (0.64 nmol/l) and 33 ng (1.11 nmol/l), respectively, and all siRNAs exhibited inhibition doses 50 within the 19-141 ng range. These results correlated well with inhibition levels of reporter SEAP activity, and confirmed that HCV RNA replication is strongly inhibited, if not abolished, in cells treated with 2 μg of the three most efficient siRNAs (si240-1a, si244, and si313). keywords: cells; figure; genotype; hcv; hepatitis; ntat2aneo; ntr; replication; replicon; rna; si240; sirnas; viral; virus cache: cord-267867-q52nvn0n.txt plain text: cord-267867-q52nvn0n.txt item: #16 of 43 id: cord-272085-4mqc8mqd author: Roques, Lionel title: Impact of Lockdown on the Epidemic Dynamics of COVID-19 in France date: 2020-06-05 words: 4240 flesch: 54 summary: COVID-19 epidemic was reported in the Hubei province in China in December 2019 and then spread around the world reaching the pandemic stage at the beginning of March 2020 (1) . If R e > 1, the number of infectious cases in the population follows an increasing trend, and the larger R e , the faster this trend. keywords: cases; covid-19; epidemic; number; population cache: cord-272085-4mqc8mqd.txt plain text: cord-272085-4mqc8mqd.txt item: #17 of 43 id: cord-275827-r86ygqmy author: Lapeyre-Mestre, Maryse title: Addictovigilance contribution during COVID-19 epidemic and lockdown in France date: 2020-06-23 words: 5012 flesch: 30 summary: Lessons from 15 years of pharmacoepidemiological contribution Ten-year trend of opioid and non-opioid analgesic use in the French adult population A capture-recapture method for estimating the incidence of off-label prescriptions: the example of baclofen for alcohol use disorder in France Identification and tracking of Addictovigilance signals in general practice: which interactions between the general practitioners and the French Addictovigilance Network? Parachuting psychoactive substances: pharmacokinetic clues for harm reduction Medical complications of psychoactive substances with abuse risks: Detection and assessment by the network of French addictovigilance centres Use of new psychoactive substances to mimic prescription drugs: The trend in France Identifying Life-Threatening Admissions for Drug Dependence or Abuse (ILIADDA): derivation and validation of a model Les CAARUD, lieux privilégiés d'émergence de signaux pour l'addictovigilance Arrêté du 19 mars 2020 complétant l'arrêté du 14 mars 2020 portant diverses mesures relatives à la lutte contre la propagation du virus COVID-19 Intérêt de la mise à disposition de la naloxone auprès des usagers de drogues pour le traitement d'urgence de surdosage d'opioïdes Améliorer la balance bénéfices/risques de la méthadone en respectant ses spécificités pharmacologiques Psychopathological consequences of confinement Pharmacovigilance et addictovigilance dans le contexte du COVID-19 : une surveillance renforcée Detection of signals of abuse and dependence applying disproportionality analysis Early signal of diverted use of tropicamide eye drops in France Pregabalin use disorder and secondary nicotine dependence in a woman with no substance abuse history Patterns of gabapentin and pregabalin use and misuse: Results of a population-based cohort study in France Drug abuse monitoring: which pharmacoepidemiological resources at the European level? Warning on increased serious health complications related to non-medical use of nitrous oxide Use of multiple sources and capture-recapture method to estimate the frequency of hospitalizations related to drug abuse Evidence of clonazepam abuse liability: results of the tools developed by the French Centers for Evaluation and Information on Pharmacodependence (CEIP) network Slow-release oral morphine sulfate abuse: results of the postmarketing surveillance systems for psychoactive prescription drug abuse in France Example of an investigation of an emergent phenomenon in addiction vigilance: the case of methylphenidate Medical prescriptions falsified by the patients: a 12-year national monitoring to assess prescription drug diversion Pharmaciens d'officine, étudiants en pharmacie et demandes de médicaments à base de codéine : étude observationnelle Disproportionality analysis for the assessment of abuse and dependence potential of pregabalin in the French Pharmacovigilance database Detecting the diverted use of psychoactive drugs by adolescents and young adults: A pilot study Site de l'association française des centres d'addictovigilance The French Addictovigilance network would like to acknowledge all persons in the 13 addictovigilance centres who participated in the active monitoring during this period (all health professionals who reported cases during the period, and persons in charge of psychoactive drugs at the ANSM (Aldine Fabreguettes, Emilie Monzon, Charlotte Pion, Nathalie Richard). This monitoring program has been useful to identify addictovigilance signals or characterize the abuse potential of prescription drugs [32, [39] keywords: abuse; addictovigilance; covid-19; drugs; health; lockdown; methadone; monitoring; network; period; prescription; substances cache: cord-275827-r86ygqmy.txt plain text: cord-275827-r86ygqmy.txt item: #18 of 43 id: cord-282095-cbfyydi3 author: Pierron, Denis title: Smell and taste changes are early indicators of the COVID-19 pandemic and political decision effectiveness date: 2020-10-14 words: 6449 flesch: 46 summary: Finally, a comparative study in Israel 20 showed that in COVID-19 suspected patient the frequency of smell change is almost ten time higher in a COVID-19 positive patients (68%) than in COVID-19 negative (8%). We propose that an increase in the incidence of sudden smell and taste change in the general population may be used as an indicator of COVID-19 spread in the population. keywords: changes; covid-19; data; france; french; lockdown; self; smell; survey; symptoms; taste; taste changes cache: cord-282095-cbfyydi3.txt plain text: cord-282095-cbfyydi3.txt item: #19 of 43 id: cord-284616-jgtsl06q author: Harkouk, Hakim title: Urgent development of an anaesthesiology-based intensive care unit for critical COVID-19 infected patients date: 2020-05-04 words: 1047 flesch: 26 summary: We report our experience with mobilisation of an anaesthesia team and use of existing structures for urgent creation of an ICU managing critical COVID-19 patients in a pandemic which exceeds the usual resources of resuscitation structures. Beyond this first adaptation, the major influx of patients imposes to rapidly manage critical patients outside the usual intensive care structures, in addition to required care of surgical patients. keywords: paris; paré; publique cache: cord-284616-jgtsl06q.txt plain text: cord-284616-jgtsl06q.txt item: #20 of 43 id: cord-285187-1h5tjs0r author: Kuchenbuch, Mathieu title: An accelerated shift in the use of remote systems in epilepsy due to the COVID-19 pandemic date: 2020-08-31 words: 4828 flesch: 47 summary: key: cord-285187-1h5tjs0r authors: Kuchenbuch, Mathieu; d’Onofrio, Gianluca; Wirrell, Elaine; Jiang, Yuwu; Dupont, Sophie; Grinspan, Zachary M.; Auvin, Stephane; Wilmshurst, Jo M.; Arzimanoglou, Alexis; Cross, J. Helen; Specchio, Nicola; Nabbout, Rima title: An accelerated shift in the use of remote systems in epilepsy due to the COVID-19 pandemic date: 2020-08-31 journal: Epilepsy Behav DOI: 10.1016/j.yebeh.2020.107376 sha: doc_id: 285187 cord_uid: 1h5tjs0r PURPOSE: The purpose of the study was to describe epileptologists' opinion on the increased use of remote systems implemented during the COVID-19 pandemic across clinics, education, and scientific meetings activities. keywords: china; covid-19; epilepsy; face; france; italy; pandemic; remote; respondents; systems cache: cord-285187-1h5tjs0r.txt plain text: cord-285187-1h5tjs0r.txt item: #21 of 43 id: cord-288079-rr8h5dgy author: Prague, Melanie title: Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate date: 2020-04-24 words: 8629 flesch: 52 summary: Although this does not represent the full extend of hospitalized COVID-19 cases, it is the only public data available that early in the epidemic, when the majority of COVID-19 cases at hospitals were admitted through emergency rooms. key: cord-288079-rr8h5dgy authors: Prague, Melanie; Wittkop, Linda; Clairon, Quentin; Dutartre, Dan; Thiebaut, Rodolphe; Hejblum, Boris Pierre title: Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate date: 2020-04-24 journal: nan DOI: 10.1101/2020.04.21.20073536 sha: doc_id: 288079 cord_uid: rr8h5dgy We propose a population approach to model the beginning of the French COVID-19 epidemic at the regional level. keywords: april; cases; covid-19; data; epidemic; license; medrxiv; model; number; preprint cache: cord-288079-rr8h5dgy.txt plain text: cord-288079-rr8h5dgy.txt item: #22 of 43 id: cord-292475-jrl1fowa author: Abry, Patrice title: Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization date: 2020-08-20 words: 7472 flesch: 46 summary: The tool also provides local trends that permit to forecast short-term future values of R. The proposed tools were applied to pandemic incidence data consisting of daily counts of new infections, from several databases providing data either worldwide on an aggregated percountry basis or, for France only, based on the sole hospital counts, spread across the French territory. This calls for a triplet of constraints: i) robust access to fast-collected data; ii) semi-parametric models for such data that focus on a subset of critical parameters; iii) estimation procedures that are both elaborated enough to yield robust estimates, and versatile enough to be used on a daily basis and applied to (often-limited in quality and quantity) available data. keywords: data; estimation; ffi; france; number; pandemic; r(t; reproduction; time cache: cord-292475-jrl1fowa.txt plain text: cord-292475-jrl1fowa.txt item: #23 of 43 id: cord-296081-6coxz3l8 author: SOURIS, M. title: COVID-19: Spatial Analysis of Hospital Case-Fatality Rate in France date: 2020-05-20 words: 3917 flesch: 50 summary: A typology combining hospitalization rates and case-fatality rates is proposed: low 302 rates (values below the mean by less than one standard deviation), high rates (values 303 . fatality rate calculated for France and the case-fatality rates presented using 387 international WHO data is highly probably the result of a difference in the registration 388 of cases and/or deaths and not due to the quality of health care. keywords: case; fatality; license; preprint; rate cache: cord-296081-6coxz3l8.txt plain text: cord-296081-6coxz3l8.txt item: #24 of 43 id: cord-299846-yx18oyv6 author: Amar, Patrick title: Pandæsim: An Epidemic Spreading Stochastic Simulator date: 2020-09-18 words: 6362 flesch: 52 summary: A modelling study Transmission interval estimates suggest pre-symptomatic spread of COVID-19 Coronavirus Latest: Scientists Scramble to Study Virus Samples Transmission dynamics of the COVID-19 outbreak and effectiveness of government interventions: A data-driven analysis The effectiveness of quarantine and isolation determine the trend of the COVID-19 epidemics in the final phase of the current outbreak in China Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: A modelling study The Behavior of an SIR Epidemic Model with Stochastic Perturbation The long time behavior of DI SIR epidemic model with stochastic perturbation A stochastic SIRS epidemic model with infectious force under intervention strategies A stochastic differential equation SIS epidemic model A multi-regional epidemic model for controlling the spread of Ebola: Awareness, treatment, and travel-blocking optimal control approaches A multi-regions SIRS discrete epidemic model with a travel-blocking vicinity optimal control approach on cells Role of Media and Effects of Infodemics and Escapes in the Spatial Spread of Epidemics: A Stochastic Multi-Region Model with A Study on Herd Immunity of COVID-19 in South Korea: Using a Stochastic Economic-Epidemiological Model Epidemic Spreading in Urban Areas Using Agent-Based Transportation Models An open-data-driven agent-based model to simulate infectious disease outbreaks HSIM: An hybrid stochastic simulation system for systems biology A General Method for Numerically Simulating the Stochastic Time Evolution of Coupled Chemical Reactions Stiffness in stochastic chemically reacting systems: The implicit tau-leaping method Données en Santé Publiques Info Coronavirus Covid 19 Clinical characteristics of coronavirus disease 2019 in china Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response Cluster of COVID-19 in northern France: A retrospective closed cohort study The French connection: The first large population-based contact survey in France relevant for the spread of infectious diseases Cmmid Covid-Working Group, Estimating the infection and case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess cruise ship Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship Reinfection could not occur in SARS-CoV-2 infected rhesus macaques The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application Serial interval of COVID-19 among publicly reported confirmed cases Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period The stochastic discrete solver (SDS) computes stochastic integer numbers such that, on the long run, they will average to the same values as the continuous solver. keywords: epidemic; model; number; people; population; region; state; stochastic; sub; time cache: cord-299846-yx18oyv6.txt plain text: cord-299846-yx18oyv6.txt item: #25 of 43 id: cord-314884-110nqkej author: Lansiaux, Édouard title: Covid-19 And Vit-D: Disease Mortality Negatively Correlates With Sunlight Exposure date: 2020-07-23 words: 1554 flesch: 37 summary: In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. keywords: correlation; covid-19; exposure; mortality; sunlight cache: cord-314884-110nqkej.txt plain text: cord-314884-110nqkej.txt item: #26 of 43 id: cord-318701-f9j13fsc author: Chamboredon, P. title: COVID‐19 pandemic in France: health emergency experiences from the field date: 2020-06-22 words: 4676 flesch: 44 summary: We have also drawn on our experiences as French nurses. The most reliable indicator to date remains the incidence of COVID-19 cases entering resuscitation/critical care every day, which is beginning to plateau. keywords: care; covid-19; crisis; france; government; health; measures; nurses; nursing; population cache: cord-318701-f9j13fsc.txt plain text: cord-318701-f9j13fsc.txt item: #27 of 43 id: cord-319418-ao0df0q7 author: Chire Saire, J. E. title: Study of Coronavirus Impact on Parisian Population from April to June using Twitter and Text Mining Approach date: 2020-08-18 words: 2390 flesch: 51 summary: Therefore, measuring what happens after having the pandemic under control is essential, and the economic issue is important to be monitored, since it goes hand in hand with public health policies for the containment of the pandemic [5] , so that our study will help to show changes in issues that concern the French population at this stage. Health Councils of each country promote health policies, close borders and start a partial or total lockdown. keywords: coronavirus; covid-19; health; license; pandemic; preprint cache: cord-319418-ao0df0q7.txt plain text: cord-319418-ao0df0q7.txt item: #28 of 43 id: cord-320636-mvtux07x author: Pullano, G. title: Underdetection of COVID-19 cases in France in the exit phase following lockdown date: 2020-08-12 words: 5262 flesch: 43 summary: key: cord-320636-mvtux07x authors: Pullano, G.; Di Domenico, L.; Sabbatini, C. E.; Valdano, E.; Turbelin, C.; Debin, M.; Guerrisi, C.; Kengne-Kuetche, C.; Souty, C.; Hanslik, T.; Blanchon, T.; BoeÌ�lle, P.-Y.; Figoni, J.; Vaux, S.; Campese, C.; Bernard-Stoecklin, S.; Colizza, V. title: Underdetection of COVID-19 cases in France in the exit phase following lockdown date: 2020-08-12 journal: nan DOI: 10.1101/2020.08.10.20171744 sha: doc_id: 320636 cord_uid: mvtux07x A novel testing policy was implemented in May in France to systematically screen potential COVID-19 infections and suppress local outbreaks while lifting lockdown restrictions. This may potentially result in substantial underestimates of the real number of COVID-19 cases in the country. keywords: cases; covid-19; data; france; lockdown; onset; preprint; surveillance; symptoms; testing; time cache: cord-320636-mvtux07x.txt plain text: cord-320636-mvtux07x.txt item: #29 of 43 id: cord-320773-zisujjsx author: Sabat, Iryna title: United but divided: policy responses and people's perceptions in the EU during the COVID-19 outbreak date: 2020-06-22 words: 5644 flesch: 48 summary: Explaining the need for and the advantages of such intrusive policies through trusted means of communication, while addressing people's concerns explicitly and being open about the risks of using such policy measures may help raise the support and compliance in society to a sufficient degree. Citizens were overall satisfied with their government's response to the pandemic; however, the extent of approval differed across countries and policy measures. keywords: countries; covid-19; government; health; italy; measures; people; policies; public; trust cache: cord-320773-zisujjsx.txt plain text: cord-320773-zisujjsx.txt item: #30 of 43 id: cord-322943-lvdl7puw author: Lardon, Zélie title: Imported Episodic Rabies Increases Patient Demand for and Physician Delivery of Antirabies Prophylaxis date: 2010-06-22 words: 4460 flesch: 39 summary: Found at: doi:10.1371/journal.pntd.0000723.s001 (0.07 MB DOC) Best practices in public health risk and crisis communication Communicating the threat of emerging infections to the public Six propositions on public participation and their relevance for risk communication The public's response to severe acute respiratory syndrome in Toronto and the United States Communicating the risks of a new, emerging pathogen: the case of Cryptococcus gattii Rabies and other lyssavirus diseases Estimating the public health impact of rabies Rabies in Europe in 2005 Expert consultation on rabies Epidemiology and prophylaxis of rabies in humans in France: evaluation and perspectives of a twenty-five year surveillance programme A reliable diagnosis of human rabies based on analysis of skin biopsy specimens Rabies vaccines What is an acceptable delay in rabies immune globulin administration when vaccine alone had been given previously Time series analysis : forecasting and control Revue méthodologique de quelques techniques spécifiques à l'analyse des séries temporelles en épidémiologie et santé publique A time series construction of an alert threshold with application to S. bobimorbificans in France The theory and pratice of econometrics Que penser de la rage en 1990? The constant media attention drawn by these different players during event #6 may have contributed to enhancing the sense of rabies risk, thereby prompting people to associate dog bites with We only examined national newspaper stories available in Factiva but not local newspaper reporting or television, radio and internet stories, and, thus, probably underestimated the global coverage of these episodes. keywords: arig; armc; event; france; health; number; patients; public; rabies; rpep cache: cord-322943-lvdl7puw.txt plain text: cord-322943-lvdl7puw.txt item: #31 of 43 id: cord-331509-p19dg1jw author: Bigault, Lionel title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR date: 2020-05-31 words: 4322 flesch: 50 summary: In this study we described the development and validation of a SYBR™ Green one-step RT-qPCR according to the French norm NF U47-600, for the detection and quantification of PEDV viral RNA. This method is the first, validated according a norm for PEDV and may serve as a global reference method to harmonize detection and quantification of PEDV viral RNA in both field and experimental settings. keywords: detection; epidemic; indel; method; pedv; porcine; rna; strains; virus cache: cord-331509-p19dg1jw.txt plain text: cord-331509-p19dg1jw.txt item: #32 of 43 id: cord-335215-h9p4kmss author: Follet, Jérôme title: Cryptosporidium infection in a veal calf cohort in France: molecular characterization of species in a longitudinal study date: 2011-12-02 words: 4343 flesch: 48 summary: in neonatal calves in Northern Ireland Molecular epidemiology of Cryptosporidium subtypes in cattle in England Cryptosporidium genotype and subtype distribution in raw wastewater in Shanghai, China: evidence for possible unique Cryptosporidium hominis transmission Molecular epidemiology of cryptosporidiosis: an update Cryptosporidium parvum mixed genotypes detected by PCR-restriction fragment length polymorphism analysis Identification of genotypically mixed Cryptosporidium parvum populations in humans and calves New view on the agespecificity of pig Cryptosporidium by species-specific primers for distinguishing Cryptosporidium suis and Cryptosporidium pig genotype II A multiplex polymerase chain reaction assay to simultaneously distinguish Cryptosporidium species of veterinary and public health concern in cattle Characteristics of Cryptosporidium transmission in preweaned dairy cattle in Henan Cryptosporidium parvum infection in bovine neonates: dynamic clinical, parasitic and immunologic patterns Resistance of calves to Cryptosporidium parvum: effects of age and previous exposure Cryptosporidium parvum in calves: kinetics and immunoblot analysis of specific serum and local antibody responses (immunoglobulin A in cattle in Michigan: implications for understanding the transmission dynamics Risk factors associated with Cryptosporidium parvum infection in cattle Cryptosporidium and Giardia in different age groups of Danish cattle and pigs-occurrence and management associated risk factors Epidemiology of Cryptosporidium spp. keywords: age; animals; bovis; calves; cryptosporidium; parvum; prevalence; ryanae; species cache: cord-335215-h9p4kmss.txt plain text: cord-335215-h9p4kmss.txt item: #33 of 43 id: cord-335252-med3c01q author: Fovet, Thomas title: Prisons confinées: quelles conséquences pour les soins psychiatriques et la santé mentale des personnes détenues en France? date: 2020-05-08 words: 3648 flesch: 41 summary: Les remaniements en lien avec le confinement donnent une visibilité accrue au fossé qui sépare la psychiatrie en milieu libre de la psychiatrie en milieu pénitentiaire. Les remaniements en lien avec le confinement donnent une visibilité accrue au fossé qui sépare la psychiatrie en milieu libre de la psychiatrie en milieu pénitentiaire. keywords: confinement; covid-19; des; france; health; les; milieu; personnes; prisons; pénitentiaire; sur cache: cord-335252-med3c01q.txt plain text: cord-335252-med3c01q.txt item: #34 of 43 id: cord-335297-vxhta6a4 author: Véran, Emilie title: Chyloabdomen in a cat with pancreatic carcinoma date: 2018-11-24 words: 2551 flesch: 42 summary: Neoplastic disease is a leading cause of chylous abdominal effusion in cats. Pancreatic carcinoma is an uncommon tumor in cats with a high metastatic rate and a poor prognosis (Linderman et al., 2013) . keywords: cat; cats; chyloabdomen; effusion; et al cache: cord-335297-vxhta6a4.txt plain text: cord-335297-vxhta6a4.txt item: #35 of 43 id: cord-337744-g17qe8fi author: Pullano, G. title: Population mobility reductions during COVID-19 epidemic in France under lockdown date: 2020-06-01 words: 6652 flesch: 47 summary: key: cord-337744-g17qe8fi authors: Pullano, G.; Valdano, E.; Scarpa, N.; Rubrichi, S.; Colizza, V. title: Population mobility reductions during COVID-19 epidemic in France under lockdown date: 2020-06-01 journal: nan DOI: 10.1101/2020.05.29.20097097 sha: doc_id: 337744 cord_uid: g17qe8fi On March 17, 2020, French authorities implemented a nationwide lockdown to respond to COVID-19 epidemic emergency and curb the surge of patients requiring critical care, similarly to other countries. Once lockdown entered into effect, population mobility reductions were heterogeneous across regions. keywords: covid-19; data; epidemic; france; license; lockdown; medrxiv; mobility; preprint; reduction; trips cache: cord-337744-g17qe8fi.txt plain text: cord-337744-g17qe8fi.txt item: #36 of 43 id: cord-339820-x8r27w14 author: Guan, L. title: Transport effect of COVID-19 pandemic in France date: 2020-07-29 words: 5391 flesch: 54 summary: https://doi.org/10.1101/2020.07.27.20161430 doi: medRxiv preprint pandemic transmission with city i. All the other parameters are chosen as the 305 ones of the region to which each city belongs. There is one basic model of modelling pandemic transmission which is well known as susceptible-infected-recovereddead (SIRD) model in [9] . keywords: copyright; holder; july; lockdown; medrxiv preprint; model; perpetuity; preprint cache: cord-339820-x8r27w14.txt plain text: cord-339820-x8r27w14.txt item: #37 of 43 id: cord-340298-0l4pec0z author: Terriau, A. title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model date: 2020-05-01 words: 3971 flesch: 50 summary: key: cord-340298-0l4pec0z authors: Terriau, A.; Albertini, J.; Poirier, A.; LE BASTARD, Q. title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model date: 2020-05-01 journal: nan DOI: 10.1101/2020.04.26.20080531 sha: doc_id: 340298 cord_uid: 0l4pec0z Background In response to the SARS-CoV2 pandemic, governments have adopted a variety of public health measures. Our estimates reveal that a 1 pp increase in the tests/hospitalizations ratio leads to a statistically significant drop of case mortality rate by 0.001 pp. keywords: covid-19; department; health; license; preprint; rate; testing; tests cache: cord-340298-0l4pec0z.txt plain text: cord-340298-0l4pec0z.txt item: #38 of 43 id: cord-344020-8poerd09 author: Vermeulen, Tom D title: Autochthonous dengue in two Dutch tourists visiting Département Var, southern France, July 2020 date: 2020-10-01 words: 1828 flesch: 50 summary: Interestingly, one of her family members upon our clinical suspicion of dengue virus infection spontaneously acknowledged having seen tiger mosquitoes (Aedes albopictus) around their holiday home. Autochthonous DENV infection was first reported in France in 2010 and has since been reported at an almost yearly basis [12, 13] . keywords: day; dengue; denv; france; patient; virus cache: cord-344020-8poerd09.txt plain text: cord-344020-8poerd09.txt item: #39 of 43 id: cord-344984-mg779mix author: Bitar, Dounia title: Risques d’importation des maladies infectieuses exotiques en France métropolitaine : détection, alerte et réponse date: 2009-11-30 words: 3772 flesch: 43 summary: Il peut s'agir d'entités cliniques d'origine infectieuse nouvellement apparues ou identifiées, d'entités pathologiques infectieuses connues dont l'incidence augmente dans un espace ou dans un groupe de population donné ou d'une modification qualitative et/ou quantitative des caractéristiques de l'agent, de la maladie, de la population touchée et de son environnement. L'organisation de la réponse est facilitée lorsqu'un keywords: cas; ces; dans; des; est; france; les; mesures; par; pour; risque; sanitaire; santé; sont; surveillance; une; veille cache: cord-344984-mg779mix.txt plain text: cord-344984-mg779mix.txt item: #40 of 43 id: cord-347244-abxv2mkz author: Izopet, Jacques title: Hepatitis E Virus Strains in Rabbits and Evidence of a Closely Related Strain in Humans, France date: 2012-08-17 words: 3885 flesch: 45 summary: Comparison with HEV sequences of human strains and reference sequences identified a human strain closely related to rabbit strain HEV. Phylogenetic analyses, conducted on the basis of a 189-nt fragment within ORF2 of the 37 HEV strains from rabbits, HEV3 strains from humans circulating in France, and HEV reference sequences (HEV1, HEV2, HEV3, HEV4, rabbit HEV, rat HEV, wild-boar HEV) indicated that the 37 new ORF2 sequences from rabbit HEVs were clustered. keywords: france; hepatitis; hev; human; liver; rabbits; sequences; strains; virus cache: cord-347244-abxv2mkz.txt plain text: cord-347244-abxv2mkz.txt item: #41 of 43 id: cord-350571-6tapkjb6 author: None title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 words: 106086 flesch: 45 summary: Clinical pharmacists have a role to evaluate and optimize the appropriateness and effectiveness of patient's medications. DTSIs interventions (treatment group) consist in: motivational interview, sharing and delivery of printed, explanatory material in the patient's native language, reconciliation of patients medications at hospital admission and at discharge; identification of potential risks due to drug-drug interactions; monitoring of compliance to drug therapy, and finally detection of adverse drug reactions (ADRs) occurring in the course of care. keywords: abstract; adherence; administration; admission; age; aim; analysis; antibiotics; assessment; associated; average; background; cancer; care; cases; clinical; community; conclusion; control; criteria; data; day; days; department; design; discharge; discrepancies; disease; dispensing; dosage; dose; drug; effects; following; general; group; guidelines; health; home; hospital; hospital pharmacy; impact; increase; information; interactions; interventions; knowledge; level; main; management; mean; measures; median; medical; medication; medication adherence; medication reconciliation; medicines; method; monitoring; months; n =; non; number; nurses; objective; oral; order; outcome; outcome measures; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; potential; practice; prescribed; prescription; problems; process; projects; quality; research; results; review; risk; risk patients; role; safety; score; service; setting; study; survey; team; therapy; time; total; treatment; type; university; use; years cache: cord-350571-6tapkjb6.txt plain text: cord-350571-6tapkjb6.txt item: #42 of 43 id: cord-355038-o2hr5mox author: None title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: 102622 flesch: 49 summary: No significant difference between the NE and AVP groups for lactate clearance between H0 and H6 (25.6 [− 7.31 to 35.34]% vs 47.84 [13.42-82.73 ]%, p = 0.686). D: blood frequency of MAIT cells in patients with pneumonia compared with healthy controls (as % of total T cells) keywords: 0.001; acute; admission; adult patients; age; aim; aki; analysis; antibiotic; ards; ards patients; association; blood; cardiac; care; care patients; care unit; cases; characteristics; children; cohort; compliance; complications; conclusion; conflict; control; data; days; death; diagnosis; disclosure; disease; duration; dysfunction; early; ecmo; end; ethics regulations; factors; failure; fig; following; france; group; high; hospital; hospital mortality; icu admission; icu mortality; icu patients; icu stay; impact; incidence; infection; influenza patients; injury; intensive; intensive care; interest; international; intubation; january; length; management; mean; median; medical; methods; model; months; mortality; mortality rate; multivariate; n =; national; niv; non; objective; outcome; p =; patients; period; pneumonia; post; pressure; prognosis; pulmonary; rate; rationale; respiratory; results; risk; score; sepsis; septic; severity; shock; sofa; stay; studies; study; study period; support; survival; syndrome; therapy; time; total; treatment; unit; use; ventilation; weaning; years cache: cord-355038-o2hr5mox.txt plain text: cord-355038-o2hr5mox.txt item: #43 of 43 id: cord-355549-6xnjj5h5 author: Cécile, Couchoud title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 words: 4018 flesch: 44 summary: key: cord-355549-6xnjj5h5 authors: Cécile, Couchoud; Florian, Bayer; Carole, Ayav; Clémence, Béchade; Philippe, Brunet; François, Chantrel; Luc, Frimat; Roula, Galland; Maryvonne, Hourmant; Emmanuelle, Laurain; Thierry, Lobbedez; Lucile, Mercadal; Olivier, Moranne title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. 6xnjj5h5 The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. keywords: care; covid-19; dialysis; disease; france; mortality; patients; population; risk cache: cord-355549-6xnjj5h5.txt plain text: cord-355549-6xnjj5h5.txt