item: #1 of 79 id: cord-000083-3p81yr4n author: None title: Poster Exhibition date: 2009-01-31 words: 113010 flesch: 51 summary: From this group of HBV patients 35 (98%) have had elevated urinal Dol excreation (45,8±5,2 g/ml vs . 3% and 47.4 respectively in HCC patients, 60.3% and 39.7 in LC patients, 55% and 40 in CHB patients, 55% and 40 in ACLF patients. keywords: 1,2; 2008; abbott; abdominal; ability; ablation; abnormal; absence; accuracy; acid; aclf; aclf patients; activation; active; activity; acute; acute hepatitis; acute liver; addition; adefovir; adiponectin; administration; adult; adv; advanced; advanced hcc; adverse; afp; age; agent; ahb; aids patients; aim; aims; alanine; albumin; alcoholic; alfa-2a; allele; alpha; alt; alt group; alt levels; alternative; amino; aminotransferase; amplicor; analogues; analysis; anemia; angiogenesis; angiogenic; animals; anti; antibody; antigen; antioxidant; antiviral; antiviral therapy; antiviral treatment; apoptosis; apoptotic; approach; area; arm; arterial; ascites; asian; asian patients; assay; assessment; associated; association; ast; asymptomatic; available; average; b virus; background; bangladesh; basal; baseline; baseline hbv; basic; bcaa; bcp; beijing; benefit; better; bile; biliary; bilirubin; binding; biochemical; biomarkers; biopsies; bleeding; blood; blot; bmi; body; breakthrough; calculated; cancer; cancer patients; carcinoma; carcinoma patients; carriers; cases; caspase; cause; cccdna; cd25; cd4; cd8; cells; center; ceus; chain; change; characteristics; characterized; chb patients; chc; chemotherapy; chen; child; children; china; chinese patients; cholesterol; chronic hbv; chronic hepatitis; chronic liver; chronic viral; cirrhosis group; cirrhotic patients; cisplatin; classification; cld; clearance; clevudine; clinical; clinical study; clones; cobas; cohort; colon; combination; combination therapy; combination treatment; combined; common; comparable; comparison; complete; complications; concentration; conclusion; condition; consecutive patients; content; continued; contrast; contribute; control; control group; conventional; copies; copper; correlation; cost; countries; counts; course; cox; criteria; cross; crp; crucial; culture; cumulative; curative; curve; cycle; cytokines; cytometry; daily; damage; data; days; dcp; death; december; decline; decreased; degree; dendritic; density; department; detection; determined; developed; developing; development; diabetes; diabetic patients; diagnosis; diameter; diet; differences; different; difficult; dipivoxil; direct; diseases; distribution; divided; dna levels; dna load; dna negative; dna positive; donors; dose; double; drug; duration; dynamic; dysfunction; early; effect; effective; effectiveness; efficacy; elder patients; elecsys; elevated; elevation; elisa; emergence; encephalopathy; end; endoscopic; endpoint; enhanced; entecavir; entry; enzyme; esophageal; essential; established; ethanol; etiology; etv; evaluation; events; evidence; evr; examination; excretion; experienced; experimental; exposure; expression; expression level; extent; extract; factors; failure; fatty liver; features; fed; female; fetoprotein; fibrosis; fibrotic; findings; flare; flow; fold; follow; following; formation; free; frequency; frequent; function; gallbladder; gallstones; gastric; gender; gene; general; genetic; genome; genomic; genotype; genotyping; ggt; glucose; glutathione; good; gpc-3; grade; greater; group; group b; growth; hand; hav; hbc; hbeag; hbeag level; hbeag negative; hbeag positive; hbeag seroconversion; hbs; hbv carriers; hbv cccdna; hbv dna; hbv genotype; hbv group; hbv infection; hbv reactivation; hbv replication; hbv therapy; hbv treatment; hbv viral; hbvdna; hcc cases; hcc cell; hcc group; hcc patients; hcclm3; hccs; hcv; hcv rna; healthy; hepatectomy; hepatic; hepatic fibrosis; hepatic hbv; hepatitis b; hepatitis group; hepatitis patients; hepatocarcinogenesis; hepatocellular; hepatocellular carcinoma; hepatocytes; hepatoma; hepg2; hev; hfgl2; high hbv; high serum; higher; histological; history; hiv; hla; hospital; host; hours; hscs; human; hvpg; hypertension; ifn; igg4; iii; il-10; il-6; il-8; images; imaging; immune; immunohistochemical; impact; important; improved; improvement; inactive; incidence; increase; independent; index; india; individuals; induction; infected; inflammation; inflammatory; influence; inhibited; inhibitor; initial; injection; injury; institute; insulin; intensity; interferon; interval; intrahepatic; intrahepatic hbv; introduction; invasion; invasive; investigation; iron; isolated; january; japan; jaundice; july; key; kidney; kinase; klf8; known; korea; laboratory; lamivudine; lamivudine group; lamivudine treatment; large; later; ldt; leading; length; leptin; lesions; levels; like; limited; linear; lines; lipid; lipiodol; liver; liver biopsy; liver cancer; liver cells; liver cirrhosis; liver damage; liver disease; liver failure; liver function; liver injury; liver stiffness; liver tissue; liver transplantation; liver tumor; load; local; log10; long; loss; low; lower; lsm; lvd; lymphocytes; lymphoma patients; main; major; majority; male; male patients; malignant; management; markers; mars; mass; materials; mean; mean age; mean hbv; measurement; mechanism; median; medical; medicine; medium; meld; metabolic; metastasis; methods; mice; microarray; mild; mixed; model; molecular; molecules; monitoring; monotherapy; months; mortality; mouse; mrna; multiple; multivariate; muscle; mutant; mutation; mvi; nafld patients; nash; nash patients; national; naïve patients; nbnc; necessary; necrosis; need; needle; negative chronic; negative hbv; negative patients; neovascularization; new; nodules; non; nonalcoholic; normal; normal alt; normal liver; normalization; novel; npv; nuclear; nucleos(t)ide; nucleoside; number; obese; objective; observed; occult hbv; odds; old; order; outcome; overall; overexpression; overlapping; oxidative; p<0.001; p<0.05; parameters; partial; pathogenesis; pathological; pathway; patients; patients chronic; patients genotype; patients group; patterns; pbmcs; pcr; pd-1; peak; peg; peg10; peginterferon; pegylated; people; percentage; percutaneous; performance; period; peripheral; phase; phc patients; phg; phylogenetic; placebo; plasma; plasmid; platelet; play; plt; plus; point; polymerase; polymorphism; poor; population; portal; positive cells; positive chb; positive chronic; positive patients; positive rate; possibility; possible; post; poster; potential; ppv; practice; predictive; predictors; pregnant; presence; present; present study; pressure; pretreatment; prevalence; previous; primary; prior; problem; procedure; profile; prognosis; progression; proliferation; prolonged; promoter; proportion; prospective; protein; protein expression; prothrombin; pugh; purpose; quality; quantification; quantitative; quantity; rabbits; radiofrequency; randomized; range; rapid; rate; ratio; rats; reaction; reactive; real; recent; receptor; recipients; recombinant; records; recurrence; reduced; reduction; refractory patients; region; regulation; regulatory; relapse; related; relationship; relative; replication; reported; reports; research; resection; resistance; resistant hbv; resistant patients; respectively; response; response rate; results; retrospective; reverse; rfa; ribavirin; risk; risk patients; rna; roche; role; rosiglitazone; routine; rvr; sae; safety; saline; samples; sbp; score; screening; sensitive; sensitivity; sequence; sequencing; sera; seroconversion; serological; serum alt; serum hbv; serum levels; session; severe; severity; sex; signal; signaling; significance; significant difference; significant fibrosis; significantly; similar; simple; simulation; single; sirna; site; size; small; sodium; somani; sonazoid; south; specific; specificity; spleen; splenic; stable; stage; staining; standard; statistical; status; steatohepatitis; steatosis; stellate; step; strain; stress; studies; study; study group; study patients; subjects; substitutions; suppression; surface; surgery; surveillance; survival; sustained; svr; svr patients; switching; syndrome; system; t cells; t12; tace; taiwan; target; technique; telbivudine; terlipressin; test; testing; therapeutic; therapies; therapy; therapy group; time; tissue; tlr2; tlr4; tnf; total; total hbv; toxicity; transaminase; transcription; transmission; transplantation; treatment; treatment group; treatment patients; treatment response; treatment results; treg; trials; tumor; tvr; types; ultrasonography; underwent; undetectable; undetectable hbv; univariate; university; unknown; untreated; urine; use; useful; vaccination; vaccine; value; variables; variations; variceal; varices; vascular; vegf; vein; venous; viral; viral hepatitis; viral load; virologic; virus; vitro; vivo; volume; wang; wd patients; weeks; weight; western; wild; withdrawal; women; workers; years; young patients; younger; zhang; zinc cache: cord-000083-3p81yr4n.txt plain text: cord-000083-3p81yr4n.txt item: #2 of 79 id: cord-000736-6f8vyziv author: Pripuzova, Natalia title: Development of Real-Time PCR Array for Simultaneous Detection of Eight Human Blood-Borne Viral Pathogens date: 2012-08-17 words: 6827 flesch: 47 summary: The results of sensitivity testing of the real-time PCR array primer sets specific for HIV-1, HIV-2, HBV, HCV, and WNV the with FDA/CBER analytical plasma panels. Example of the experimental testing of HIV-1 specific primer set targeting gag gene (NP3/4) for its sensitivity with DNA analytical standards is shown in Figure S1 . keywords: amplification; analytical; array; assay; blood; c(t; cber; clinical; conserved; control; copies; copy; cut; data; detection; development; different; dna; donors; fda; figure; gene; genome; genome copies; green; group; hbv; hcv; hiv-1; human; identification; immunodeficiency; isolates; multiple; negative; number; panels; pathogens; pcr; pcr array; peaks; plasma; positive; primer; primer sets; quantification; range; reaction; real; results; rna; samples; sensitivity; sequence; sets; specific; specific primer; specificity; standards; study; subtypes; sybr; table; target; targeted; testing; time; time pcr; tissue; type; values; viral; virus; viruses; wnv cache: cord-000736-6f8vyziv.txt plain text: cord-000736-6f8vyziv.txt item: #3 of 79 id: cord-000794-l565gha4 author: Yan, Huan title: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus date: 2012-11-13 words: 13433 flesch: 47 summary: HBV HBV genotype B virus was obtained by ultracentrifugation of plasma from an HBV chronic carrier with written consent. For HBV viral infection on HepaRG cells and PHH, ∼ 4% PEG 8000 was present during the inoculation period as previously described by Gripon et al. keywords: aav8; absence; acid; acquisition; amino; amplification; analysis; antibody; antigen; b virus; beads; bile; binding; blot; buffer; cccdna; cells; cellular; control; copies; corresponding; critical; cross; culture; data; database; days; delta; dna; domain; dpi; efficiency; entry; envelope; equivalent; et al; expression; figure; fitc; genome; genotype; gripon; hbeag; hbv; hbv infection; hdv; heparg; hepatitis; hepatocytes; hepg2; huh-7; human; infected; infection; inhibited; inoculation; interpretation; kda; kit; knockdown; large; level; line; linking; liver; mab; mass; medium; min; mkntcp; monkey; mrna; myr-47; n9k; national; ntcp; page; panel; pcr; peptide; phhs; photo; plasmid; pmm; pngase; post; pre; presence; primary; primers; protein; pths; purification; real; receptor; region; residues; reverse; right; rna; rnas; samples; sds; sequence; sequencing; similar; sirna; small; sodium; specific; staining; states; streptavidin; supplement; surface; susceptible; tandem; target; terminal; time; total; transcriptome; transcripts; transfection; treatment; tsntcp; tupaia; united; viral; virus; viruses; western; wt b cache: cord-000794-l565gha4.txt plain text: cord-000794-l565gha4.txt item: #4 of 79 id: cord-001247-pxzbirqd author: Sun, Lu title: A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes date: 2014-03-22 words: 4671 flesch: 45 summary: Meanwhile, currently the mostly used methods to predict and identify T cell epitopes are either by computer algorithms based on the mode of peptide binding to MHC molecules, or measurement of T cell responses of PBMCs simulated with panels of overlapping peptides (Liu et al., 2011) . Our work may therefore provide a comprehensive evaluation of the impact of the newly defined epitope on viral specific T cell response and suggests a possible immune evasion for maintenance of viral persistence in patients with HBV infection. keywords: a*0201; a2.1; ahb; antigen; assay; binding; cd8; cell; chain; chb; chronic; complex; control; core; ctl; ctls; cytotoxic; determined; disease; dna; elispot; epitope; et al; fig; genotypes; hbc141; hbc18; hbc82; hbsag; hbv; hepatitis; hla; immune; immunization; immunized; infected; infection; liu; mice; mutations; negative; patients; peptide; positive; progression; protein; response; restricted; specific; structure; study; target; transgenic; unconventional; viral; virus cache: cord-001247-pxzbirqd.txt plain text: cord-001247-pxzbirqd.txt item: #5 of 79 id: cord-001515-x11t9pbv author: Kosinska, Anna D. title: Therapeutic vaccination and immunomodulation in the treatment of chronic hepatitis B: preclinical studies in the woodchuck date: 2014-12-23 words: 6395 flesch: 33 summary: Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B Cellular and virological mechanisms of HBV drug resistance Hepatitis B virus resistance to nucleos(t)ide analogues Long-lasting memory T cell responses following selflimited acute hepatitis B The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection Specific vaccine therapy in chronic hepatitis B: induction of Expression and purification of woodchuck tumour necrosis factor alpha Molecular cloning of the woodchuck cytokines: TNF-alpha, IFN-gamma, and IL-6 Woodchuck gamma interferon upregulates major histocompatibility complex class I transcription but is unable to deplete woodchuck hepatitis virus replication intermediates and RNAs in persistently infected woodchuck primary hepatocytes Molecular characterization of woodchuck interleukin 15 (wIL-15) and detection of its expression in liver samples of woodchucks infected with woodchuck hepatitis virus (WHV) Molecular cloning and expression of woodchuck granulocyte-macrophage colony stimulating factor Expression of a new woodchuck IFN-alpha gene by a helper-dependent adenoviral vector in woodchuck hepatitis virus-infected primary hepatocytes Molecular characterization of woodchuck type I interferons and their expression by woodchuck peripheral blood lymphocytes Molecular characterization of the type I IFN receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (WHV) Hepatitis B virus-specific T-cell proliferation and cytokine secretion in chronic hepatitis B e antibody-positive patients treated with ribavirin and interferon alpha Role of Tolllike receptor 2 in the immune response against hepadnaviral infection Lipopolysaccharide-induced innate immune responses in primary hepatocytes downregulates woodchuck hepatitis virus replication via interferon-independent pathways Molecular characterization of CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) of woodchuck (Marmota monax) Transcriptomic analysis of the woodchuck model of chronic hepatitis B Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation Ex vivo identification, isolation and analysis of tumor-cytolytic T cells The woodchuck: an animal model for hepatitis B virus infection in man Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection Induction of antibodies to the PreS region of surface antigens of woodchuck hepatitis virus (WHV) in chronic carrier woodchucks by immunizations with WHV surface antigens Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B Molecular signature of CD8+ T cell exhaustion during chronic viral infection Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade T-helper cell response to woodchuck hepatitis virus antigens after therapeutic vaccination of chronically-infected animals treated with lamivudine Combination of an antiviral drug and immunomodulation against hepadnaviral infection in the woodchuck model Immunization with surface antigen vaccine alone and after treatment with 1-(2-fluoro-5-methyl-beta-Larabinofuranosyl)-uracil (L-FMAU) breaks humoral and cellmediated immune tolerance in chronic woodchuck hepatitis virus infection Immunogenic effects of woodchuck hepatitis virus surface antigen vaccine in combination with antiviral therapy: breaking of humoral and cellular immune tolerance in chronic woodchuck hepatitis virus infection Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity Augmentation of immune responses to SARS coronavirus by a combination of DNA and whole killed virus vaccines Recombinant adenovirus induces maturation of dendritic cells via an NF-kappaB-dependent pathway Development of a preventive vaccine for Ebola virus infection in primates Attenuation of simian immunodeficiency virus SIV-mac239 infection by prophylactic immunization with dna and recombinant adenoviral vaccine vectors expressing Gag Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model Combination of DNA prime-adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model T cells and viral persistence: lessons from diverse infections By contrast, patients with chronic hepatitis B tend to have delayed, transient or narrowly focused T cell responses keywords: acute; adenoviral; analogues; animal; antibodies; antigen; antiviral; approaches; blockade; boost; carriers; cd8; cell; cellular; characterization; chb; chronic; chronic hepatitis; combination; control; cytotoxic; development; dna; effective; efficacy; etv; expression; function; gene; hbsag; hbv; hepadnaviral; hepatitis; hepatocytes; ifn; immune; immunity; immunization; induced; infected; infection; innate; interferon; lamivudine; levels; liver; load; model; new; nucleos(t)ide; patients; pd-1; prime; proteins; recombinant; replication; responses; results; specific; strategies; studies; study; suppression; surface; sustained; system; t cell; therapeutic; therapy; treatment; vaccination; vaccines; vectors; virus; whsag; whv; woodchuck cache: cord-001515-x11t9pbv.txt plain text: cord-001515-x11t9pbv.txt item: #6 of 79 id: cord-002253-ll5a0urm author: Kunanopparat, Areerat title: Increased ATG5-ATG12 in hepatitis B virus-associated hepatocellular carcinoma and their role in apoptosis date: 2016-10-07 words: 4508 flesch: 39 summary: Many cancer drug treatments increase tumor cell autophagy to protect cancer cells from apoptosis. [20] , found that Ras-driven tumors required autophagy for tumor cell survival upon starvation. keywords: activation; apoptosis; apoptotic; atg12; atg4b; atg5; atg9a; autophagy; beclin-1; cancer; carcinoma; cell; combination; conditions; control; cycle; dapt; data; expression; figure; function; genes; hbv; hbx; hcc; hepatitis; hepatocellular; hepg2.2.15; human; important; increased; induction; infection; inhibition; levels; lines; liver; mice; mrna; non; notch; pathway; pcr; progression; protein; real; replication; results; rna; role; signaling; silencing; starvation; states; study; suppressor; survival; target; time; tissues; treatment; tumor; united; virus; western cache: cord-002253-ll5a0urm.txt plain text: cord-002253-ll5a0urm.txt item: #7 of 79 id: cord-002282-ldfa616a author: Joung, Young Hee title: The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B date: 2016-10-13 words: 8150 flesch: 32 summary: Edible plant vaccines are based on different parts of plants, such as fruits, seeds, and root vegetables. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins. keywords: 35s; administration; antibodies; antibody; antigen; application; avian; b surface; b virus; banana; benthamiana; candidate; carrot; case; cell; chloroplast; clinical; core; cost; crops; culture; delivery; dengue; development; different; disease; dna; dose; edible; efe; effective; eha105; expressed; expression; fruit; fusion; gene; genome; hbsag; hbv; health; hepatitis; hepb; high; human; igg; immune; immunization; immunogenicity; infection; influenza; leaf; leaves; lettuce; level; like; long; low; maize; maximum; mice; miu; n.a; new; oral; particles; plant; plasmodium; potato; potential; production; promoter; protective; protein; purification; rapid; recombinant; research; response; rice; safety; seed; serum; signal; soybean; species; specific; stability; stable; storage; study; subunit; surface; surface antigen; suspension; system; target; term; tissue; tobacco; tomato; transformation; transgenic; transient; trials; tsp; use; vaccination; vaccine; vector; viral; virus; years; yeast cache: cord-002282-ldfa616a.txt plain text: cord-002282-ldfa616a.txt item: #8 of 79 id: cord-002687-ql6zo8ka author: Li, Dan title: A potent human neutralizing antibody Fc-dependently reduces established HBV infections date: 2017-09-26 words: 14964 flesch: 48 summary: Moreover, 2H5-A14 greatly reduced HBV infection in a treatment mouse model. HBV and HDV neutralizing assays were then performed to rank the neutralizing ability of these 16 Abs relative to that of 2H5 ( 2H5-A14 is a potent and broadly-neutralizing nAb against HBV infection that acts by blocking the binding of preS1 with the HBV receptor NTCP Competition ELISA assays showed that 2H5-A14 had almost the same peptide competition pattern as did 2H5, and mutation of G24R of preS1 did not affect 2H5-A14 binding activity, indicating that 2H5-A14 targets the same epitope as does 2H5 (Figure 2-figure supplement 4) . keywords: 2h5; 59c; a14; a14 treatment; activity; adcc; adcp; affinity; analysis; antibodies; antibody; antigen; assays; binding; block; blood; blotting; buffer; cccdna; cdc; cells; cfse; chain; challenge; chimeric; cho-59c; chronic; clinical; clones; competition; complement; complex; concentrations; control; copies; copy; culture; cytotoxicity; dana; data; day; days; dependent; dna; domain; dose; dpi; effector; efficacy; elisa; epitope; et al; experiment; expression; fcgrs; figure; figure supplement; frozen; functions; gene; genotype; group; hbig; hbsag; hbv; hbv dna; hbv infection; hdv; hepatitis; hepatocytes; hepg2; hfrg; high; hntcp; human; igg1; ihc; immune; infected; infection; interaction; kit; length; levels; library; line; liver; mab; macrophages; major; medium; membrane; mice; min; model; monoclonal; mouse; mutant; nabs; neutralization; neutralizing; non; novel; numbers; observed; pbs; peptide; phagocytosis; plates; potency; potent; prepared; pres1; presence; primers; prophylactic; protein; qpcr; receptor; region; residues; results; rna; samples; scfv; sequence; sera; serum; similar; single; solution; southern; specific; staining; structure; studies; study; supplement; surface; system; target; target cells; therapeutic; therapies; time; tissues; total; treatment; tumor; viral; virus; viruses; vitro; vivo; yan cache: cord-002687-ql6zo8ka.txt plain text: cord-002687-ql6zo8ka.txt item: #9 of 79 id: cord-002706-m3y35ozx author: Guo, Fang title: HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways date: 2017-09-25 words: 7405 flesch: 35 summary: At the time of PFA withdrawal, mock treatment or treatment with ETV, Bay-41-4109, ENAN-34017 was initiated and cells were harvested at the indicated time points for analyses of HBV core DNA and cccDNA. Extraction and analyses of HBV DNA and RNA by hybridization and realtime PCR assays HBV core DNA and RNA extraction from infected C3A hNTCP or HepAD38 cells, Southern blot hybridization, and real-time PCR analyses were performed as described previously keywords: amplification; antiviral; assay; assembly; b virus; bay; blot; buffer; c3a; cccdna; cccdna synthesis; cells; changes; circular; complete; core; cpams; culture; cytoplasmic; digestion; disassembly; dna; dnase; double; dsldna; effects; enan-34017; endogenous; etv; exposure; fig; formation; fraction; function; gel; genome; genomic; gls4; hbv; hcl; hdv; hepad38; hepatitis; hepatocytes; hntcp; host; human; hybridization; infected; infection; inhibit; inhibited; intracellular; mature; medium; membrane; mock; novo; nuclear; nucleocapsids; pathway; pcr; pgrna; polymerase; post; progeny; protein; rcdna; reaction; replication; results; rna; small; southern; species; specific; strand; structural; sucrose; synthesis; time; treatment; tris; viral; viral dna; virion; virus cache: cord-002706-m3y35ozx.txt plain text: cord-002706-m3y35ozx.txt item: #10 of 79 id: cord-003018-qrt07zmz author: Miyakawa, Kei title: Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide date: 2018-05-04 words: 5455 flesch: 36 summary: Cells were infected with wild-type HBV at a concentration of 5,000 genome equivalents per cell in the presence of 4% PEG8000 for 16 hours. Cells were treated with [ 3 H]-taurocholic acid (TCA) in a sodium-free or sodium-containing buffer at 37ºC for 15 minutes to allow TCA uptake into cells. keywords: 9a8; acid; analysis; anti; antibodies; antibody; antigen; antiviral; assay; bile; carcinoma; cell; compounds; conjugated; culture; cycle; data; dependent; downregulation; dox; drug; effect; endocytosis; entry; expression; figure; fisher; free; gene; generation; germ; glabridin; hbv; hepatitis; hepatocellular; hepatocytes; hepg2; high; hours; human; hybridoma; ifn; immunofluorescence; infected; infection; inhibits; interaction; intracellular; levels; line; liver; localization; mab; membrane; monoclonal; new; ntcp; polypeptide; pres1; primary; production; protein; receptor; recombinant; research; results; scientific; sodium; specific; study; supplementary; surface; system; taurocholate; tca; test; tetracycline; thermo; transporter; treated; treatment; type; uptake; viral; virus; wheat cache: cord-003018-qrt07zmz.txt plain text: cord-003018-qrt07zmz.txt item: #11 of 79 id: cord-003993-3bozjfv7 author: Cagliani, Rachele title: Mode and tempo of human hepatitis virus evolution date: 2019-10-25 words: 7848 flesch: 37 summary: The prehistory of the silk road The history of the camel bone dating project The appearance of the domestic camel in southeast Arabia Rabbits and the specious origins of domestication Recent knowledge on hepatitis E virus in Suidae reservoirs and transmission routes to human Estimating maximum likelihood phylogenies with PhyML Distribution of HBV genotypes in Latin America Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study RAxML version 8: a tool for phylogenetic analysis and postanalysis of large phylogenies Complete genome sequence of a hepatitis E virus genotype 1e strain from an outbreak in Nigeria Hepatitis E in Italy: 5 years of national epidemiological, virological and environmental surveillance Hepatitis E virus genotypes and subgenotypes causing acute hepatitis Quantification and genetic diversity of Hepatitis E virus in wild boar (Sus scrofa) hunted for domestic consumption in Central Italy Dakovic Rode O. Genetic diversity of hepatitis E virus (HEV) strains derived from humans, swine and wild boars in Croatia from A case of incidental infection of Hepatitis E virus (HEV) genotype 1 in a domestic pig Hepatitis E virus genotype 1 and hepatitis A virus dual infection in pediatric patients with a low socioeconomic status from Mexico Epidemiology and genotype 3 subtype dynamics of hepatitis E virus in Belgium First detection of hepatitis E virus genotype 3 as a common infectious agent in patients with chronic liver damage in Mexico A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria Hepatitis E virus seroprevalence and correlates of anti-HEV IgG antibodies in the Rakai District Hepatitis E virus infection in different groups of Estonian patients and people who inject drugs The worldwide burden of viral hepatitis in terms of death and disability is enormous. Technological advances that allow throughput sequencing of viral genomes, as well as the development of computational tools to analyze such genome data, have largely expanded our knowledge on the host range and evolutionary history of human hepatitis viruses. keywords: analysis; ancient; animals; approaches; associated; b virus; camel; case; chv; classification; common; cross; data; dating; different; distinct; distribution; diverse; diversity; domestic; ehv; emergence; epidemic; epidemiology; events; evidence; evolutionary; extant; family; fig; fish; genetic; genome; genotypes; global; hav; hbv; hcv; hdv; hepacivirus; hepadnaviruses; hepatitis; hepatoviruses; hev; high; history; horses; host; human; human hepatitis; identification; infected; infecting; infection; isolated; knowledge; large; likely; lineages; long; low; mammalian; mammals; molecular; new; non; novel; number; origin; orthohepevirus; particular; phylogenetic; phylogenies; populations; present; prevalence; primate; rate; recent; regions; related; reverse; rna; rodents; selection; sequences; single; species; specific; spread; strains; substitution; subtypes; swine; tdrp; time; transmission; variability; viral; virus; viruses; wild; world; worldwide; years; zoonotic cache: cord-003993-3bozjfv7.txt plain text: cord-003993-3bozjfv7.txt item: #12 of 79 id: cord-004605-gsi4yxzj author: None title: Prüfung und Deklaration der Wirksamkeit von Desinfektionsmitteln gegen Viren: Stellungnahme des Arbeitskreises Viruzidie* beim Robert Koch-Institut (RKI) sowie des Fachausschusses „Virusdesinfektion“ der Deutschen Gesellschaft zur Bekämpfung der Viruskrankheiten (DVV) und der Desinfektionsmittelkommission der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM) date: 2004 words: 1986 flesch: 34 summary: Die von der WHO ergriffenen Maßnahmen zur Eradikation der Poliomyelitis machen es erforderlich, dass für die Desinfektionsmittelprüfung nur der Polio-Impfstamm Typ I, Stamm LSc-2ab verwendet werden darf key: cord-004605-gsi4yxzj authors: nan title: Prüfung und Deklaration der Wirksamkeit von Desinfektionsmitteln gegen Viren: keywords: als; alteration; anforderungen; arbeitskreises; auch; auf; aus; begrenzt; behüllten; bei; bekämpfung; bga; bisher; bundesgesundheitsamtes; chemischen; das; dass; deklaration; der; des; desinfektionsmitteln; deutschen; dhbv; die; diese; disinfection; dna; durch; dvv; eine; fachausschusses; für; gegen; gegenwärtig; gesellschaft; hbsag; hbv; hcv; hepatitis; hier; hiv; human; hygiene; inactivation; infektiosität; ist; jedoch; kann; madt; nachgewiesen; nachweis; nicht; nur; oder; pcr; polio; prüfmethoden; prüfung; richtlinie; rki; rotavirus; sich; sind; test; testviren; und; unter; untersuchungen; vereinigung; verfügung; verwendung; viren; virus; virusdesinfektion; viruskrankheiten; viruzid; viruzidie; von; werden; wie; wirksamkeit; zum; zur; ähnlich cache: cord-004605-gsi4yxzj.txt plain text: cord-004605-gsi4yxzj.txt item: #13 of 79 id: cord-005953-5z89yeb6 author: None title: Abstracts des 114. Internistenkongresses 2008 date: 2008 words: 16191 flesch: 40 summary: Hohe Prävalenz der ASS-Non-Responder bei ACVB-Patienten in den multiplen Testanalysen Hintergrund und Zielsetzung: In der Therapie der HIV-Infektion sind Wechselwirkungen und Unverträglichkeit der mittlerweile zahlreich zur Verfügung stehenden antiretoviralen Medikamente ein grosses Problem. Auch in der Subgruppe der überlebenden keywords: 24h; a549; aav; able; absence; ace; activation; activity; addition; adherence; adherent; age; aim; aktivierung; aldosterone; allele; als; altman; analyse; analysis; angiotensin; animals; anti; apoptose; ar4; arbs; artery; aspirin; assay; at1; atrial; auch; auf; aus; background; baseline; behandlung; bei; beiden; bestimmt; bestimmung; bier; biphasic; bis; bland; bleeding; blood; blot; bmi; body; bzw; campesterol; cardiac; cardiovascular; carotid; carriers; cells; cellular; changes; chd; chemokine; cholesterol; class; clopidogrel; combination; common; conclusion; contrast; controls; coronary; correlation; cox-2; csf; cwd; cyp2c19; daher; das; dass; data; daten; days; degradation; dem; dependent; der; des; development; diabetes; diabetic; dialysis; die; dieser; dietary; different; dimensional; disease; dldl; drug; durch; durchgeführt; ebenfalls; effects; effekt; eine; einfluss; elegans; elevated; endogenous; endothelial; ergab; ergebnisse; et-1; expression; factors; faktoren; fat; fibrillation; fibrinogen; fibrose; fkn; flow; fluids; follow; form; function; führte; für; gdp; gegenüber; genes; genetic; glucose; goitre; group; gruppe; gute; haben; hat; hbv; hcv; hdl; healthy; heart; hemmern; hepatitis; hepatozyten; herzinsuffizienz; high; higher; hilfe; hintergrund; history; hnc; hscs; huh7.5; human; humanen; hypertension; hzv; ibp; ifn; impact; impaired; incidence; index; induced; induzierte; inflammatory; inhibition; inhibitors; insulin; interaction; ischemia; isolated; ist; jahre; jedoch; kardiologie; kardiomyozyten; key; kinase; klinisch; konnte; konzentrationen; können; lathosterol; ldl; leptin; lesions; levels; life; liraglutid; lis; lisinopril; liver; low; lower; major; mass; mean; measures; mechanismen; median; mellitus; membrane; metabolism; methoden; methods; mhc; mice; microalbuminuria; migration; min; mit; mittels; mmhg; mmol; model; monaten; months; mrna; mrt; myocardial; n.s; nach; nachgewiesen; natriumkanäle; neuronal; nicht; nnos; non; normal; ntd; number; nyha; obese; obesity; observed; oder; overexpression; oxidase; oxide; p<0.001; p<0.05; pathway; patienten; patients; peritoneal; pgd2; placebo; plasma; platelets; plättchenaggregation; positive; potential; ppg; presence; present; pressure; prevalence; primary; primären; probnp; profile; proteasome; protein; prrt; pts; randomized; rate; rats; ratten; rcm; rebreathing; receptor; reduced; reduction; regression; release; remission; renal; reperfusion; response; restriction; results; risk; role; ros; schlussfolgerung; score; sechs; serum; severe; shape; sich; signalwege; significant; sind; size; snx+gdp; soluble; source; sowie; span; specific; spectrometry; stationären; stimulation; strain; studie; study; subjects; supernatants; supportive; surface; synthase; system; systemic; tace; tgr; therapie; therapy; thyroid; time; tips; tlr; tnf; tolerance; total; transcriptional; treatment; tumor; type; uacr; ultraschall; und; unter; untereinheiten; untersucht; urine; valsartan; vascular; vegfr2; vergleich; vivo; von; vor; war; weeks; weibchen; weight; welche; werden; werte; western; wild; wir; wird; women; wurde; während; years; zeigen; zeigte; zellen; zelltod; ziel; zielsetzung; zum; zur; zwischen; über cache: cord-005953-5z89yeb6.txt plain text: cord-005953-5z89yeb6.txt item: #14 of 79 id: cord-006856-b1w25ob5 author: None title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 words: 29728 flesch: 49 summary: The average serum creatinine after 5 years is 153.56 ± 24.65 µmol/l. Cumulative graft survival after 5 years is shown by Kaplan-Meier curve: graft survival, 75.1%; patients survival, 83.9%; graft and patients survival, 67.1%. Extracorporeal photopheresis has been shown to be beneficial in acute and chronic rejection in heart transplant patients and has also been used in lung transplant recipients with acute rejection or bronchiolitis obliterans. Methods. keywords: abdominal; activation; activity; acute; addition; age; aim; alive; allogeneic; allograft; als; aml; analyse; analysis; anti; antibody; antigen; artery; ascites; assay; atg; auf; aus; autologous; average; background; bacterial; balb; basis; bei; biopsy; bleeding; blockade; blood; bmt; bnp; bone; bos; bronchial; c4d; c57bl/6; cancer; candida; cardiac; cardiomyocytes; cases; cd25; cd3; cd4; cells; cellular; center; chimerism; cholestatic; chronic; cirrhosis; clearance; clinical; cmv; cohort; cold; collection; combination; combined; common; comparable; comparison; complete; complications; conclusions; conditioning; consecutive; continuous; contrast; control; course; creatinine; criteria; csa; csf; ctla4ig; cuff; cumulative; cyclosporine; cytotect; das; data; day; days; dcm; dcs; death; decrease; dependent; der; des; diagnosis; die; dieser; different; disease; disorders; dna; donation; donor; dose; drug; dst; dysfunction; early; ecmo; effect; eine; end; episodes; ergebnisse; established; events; everolimus; excellent; expression; extended; factor; failure; female; fibrosis; follow; following; fty720; function; fungal; für; gcm; genotype; gms; good; grade; graft; graft survival; group; growth; gruppe; gvhd; h-2; hbcab; hbig; hbv; hcc; hcv; heart; hepatitis; high; higher; hl-1; ho-1; hplc; hsct; htx; human; iii; immunosuppression; impact; implantation; important; incidence; increase; induction; infection; inflammation; inhibitor; innsbruck; institution; intra; ischemia; islet; isolated; isolation; kaplan; kidney; left; levels; like; lipocalin-2; list; liver; living; long; loss; lower; lung; lung transplantation; lymphoma; majority; male; mapk; marginal; marrow; mars; mean; median; medical; meier; meld; methods; mice; microscopy; min; mit; mixed; model; moderate; mofetil; monitoring; months; mortality; multiple; mycophenolate; myeloablative; myocardial; n =; nach; negative; neoplasms; new; nicht; non; normal; number; observation; observed; organ; outcome; overall; p =; p38; pancreas; pancreatic; pap; parameters; particular; pathogens; patient survival; patienten; patients; pbsc; pcr; period; peripheral; phosphorylation; platelet; plb; population; positive; post; postoperative; posttransplant; potential; preoperative; preservation; primary; prior; probability; procedure; progression; proliferation; prophylaxis; protein; proteinuria; protocol; ptld; pts; pulmonary; quality; range; rate; ratg; ratio; recipients; recurrence; reduced; reduction; regimen; rejection; relapse; related; remission; renal; reperfusion; report; response; results; retrospective; ric; risk; role; s1p; sample; schlussfolgerungen; score; sepsis; serum; severe; sex; short; sich; significant; similar; sirolimus; skin; slpi; small; solid; solutions; specific; srl; stable; stage; standard; stem; stent; steroids; stimulation; studiengruppe; studies; study; substantial; suffering; surgical; survival; switch; system; tacrolimus; tbi; technique; term; test; tgf; therapeutic; therapy; time; tissue; tolerance; total; transplant patients; transplantation; transplanted; treatment; trm; tumor; type; underwent; university; unrelated; urine; use; values; vascular; vegf; venous; ventricular; vitro; vivo; von; waiting; war; weeks; werden; wien; wurde; years; zellen cache: cord-006856-b1w25ob5.txt plain text: cord-006856-b1w25ob5.txt item: #15 of 79 id: cord-007562-4hcs0z65 author: Bijlenga, G. title: Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands date: 2005-07-19 words: 1787 flesch: 42 summary: Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Induction of chicken interferon by avian infectious bronchitis virus The genome sequence of the SARSassociated coronavirus Specific cytotoxic T lymphocytes are involved in in vitro clearance of infectious bronchitis virus The carboxyl-terminal 120-residue polypeptide of infectious bronchitis virus nucleocapsid induces cytotoxic T lymphocytes and protect chickens from acute infection Cytotoxic T lymphocytes responses to infectious bronchitis virus infection Adoptive transfer of infectious bronchitis virus primed alphabeta T cells bearing CD8 antigen protects chicks from acute infection Mosaic evolution of the severe acute respiratory syndrome coronavirus Potential for polyvalent infectious bronchitis vaccines Study of protection by recombinant fowlpox expressing C-terminal nucleocapsid protein of infectious bronchitis virus against challenge 74250 La Tour-en-Faucigny, France Q 2005 key: cord-007562-4hcs0z65 authors: Bijlenga, G. title: Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands date: 2005-07-19 journal: J Infect DOI: 10.1016/j.jinf.2005.04.010 sha: doc_id: 7562 cord_uid: 4hcs0z65 nan Occult hepatitis B virus infection among anti-HBc positive blood donors: Necessitates substitution of screening by HBV NAT Safe blood transfusion still remains a major concern and so far all the efforts in this direction have failed to achieve zero residual risk of transfusion transmitted hepatitis B virus (HBV) infection. keywords: anti; avian; blood; bronchitis; challenge; collected; coronavirus; dna; donors; hbc; hbs; hbv; high; induction; infectious; level; monkeys; positive; positivity; protection; protein; sars; strain; transfusion; units; vaccine; virus cache: cord-007562-4hcs0z65.txt plain text: cord-007562-4hcs0z65.txt item: #16 of 79 id: cord-009636-5kddituy author: Shirbaghaee, Zeinab title: Different applications of virus‐like particles in biology and medicine: Vaccination and delivery systems date: 2015-12-22 words: 8739 flesch: 47 summary: 25, 157 Different experiments have been concentrated on HPV VLP vaccination in mouse and human models including: (a) activation of immature human DCs by chimeric HPV16 VLPs, (b) determination of systemic cytokine pattern elicited by HPV L1 VLPs, (c) identification of gene expression signatures in HPV16 L1 VLP-induced human PBMCs, (d) generation of potent and prolonged neutralizing L1 antibodies using a single intramuscular (IM) mice injection with recombinant adenoassociated virus encoding HPV16 L1 protein (rAAV-16L1), (e) augmentation of immunogenicity of HPV L1 DNA vaccines using genetic linkage to a chemokine and secretory signal peptide sequences, (f) potent stimulation of systemic and mucosal immune responses to VLP vaccines using the encapsulation of a genetic cytokine adjuvant (e.g., IL-2), (g) improvement of HPV16 VLP immunogenicity by linkage to the modified adjuvant, and m) nasal immunization of mice with HPV16 VLPs. The potential of VLPs to target DCs is a main advantage of VLP vaccines, for activating the innate and adaptive immune responses. keywords: able; activation; addition; adjuvant; antibodies; antibody; antigen; applications; assembly; bacterial; bacteriophage; baculovirus; cancer; capsid; cells; cellular; cerevisiae; challenge; chimeric; class; clinical; coat; cross; dcs; delivery; design; development; different; dna; drugs; efficient; enveloped; epitopes; example; expression; foreign; formation; fusion; gag; gene; generation; genetic; glycoproteins; gp120; hand; hbc; hbsag; hbv; hepatitis; high; hiv; hiv-1; hpv; hpv16; human; humoral; immune; immunity; immunization; immunogenicity; infectious; influenza; insect; levels; like; like particles; low; major; mammalian; mhc; mice; molecules; ms2; mucosal; non; particles; peptide; plant; potent; potential; presentation; production; properties; protective; protein; recombinant; responses; similar; sirna; soluble; specific; stimulation; strategy; structures; studies; surface; systemic; systems; targeting; terminal; tfn; therapeutic; therapy; trials; types; uptake; use; vaccination; vaccine; viral; virus; viruses; vitro; vivo; vlps; yeast cache: cord-009636-5kddituy.txt plain text: cord-009636-5kddituy.txt item: #17 of 79 id: cord-009813-o8ai730r author: Wang, Wei title: Major vault protein plays important roles in viral infection date: 2019-11-26 words: 4566 flesch: 16 summary: The drug resistance-related protein LRP is the human major vault protein The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes Vaults and telomerase share a common subunit, TEP1 Vaults are upregulated in multidrugresistant cancer cell lines Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex Characterization of the sea urchin major vault protein: A possible role for vault ribonucleoprotein particles in nucleocytoplasmic transport Mechanisms underlying lung resistance-related protein (LRP)-mediated doxorubicin resistance of non-small cell lung cancer cells Molecular basis for the expression of major vault protein induced by hyperosmotic stress in SW620 human colon cancer cells Major vault protein (MVP) gene polymorphisms and drug resistance in mesial temporal lobe epilepsy with hippocampal sclerosis Major vault protein, in concert with constitutively photomorphogenic 1, negatively regulates c-Jun-mediated activator protein 1 transcription in mammalian cells PTEN associates with the vault particles in HeLa cells Crosstalk between Src and major vault protein in epidermal growth factordependent cell signalling The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals Phosphatase and Tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein Lung resistance-related protein as a predictor of clinical outcome in advanced testicular germcell tumours On the role of major vault protein in the resistance of senescent human diploid fibroblasts to apoptosis Listeria and autophagy escape: Involvement of InlK, an internalin-like protein Host resistance to lung infection mediated by major vault protein in epithelial cells Evaluation of MDR1, LRP, MRP, and topoisomerase IIalpha gene mRNA transcripts before and after interferonalpha, and correlation with the mRNA expression level of the telomerase subunits hTERTand TEP1 in five unselected human melanoma cell lines Innate immunity to virus infection Pathogen recognition and innate immunity RIG-I-mediated antiviral responses to single-stranded RNA bearing 5 0 -phosphates Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5 IRF-7 is the master regulator of type-I interferon-dependent immune responses IRF family of transcription factors as regulators of host defense Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response Toll-like receptors in innate immunity The immunobiology of the TLR9 subfamily Pattern recognition receptors and control of adaptive immunity A diverse range of gene products are effectors of the type I interferon antiviral response Inducible major vault protein plays a pivotal role in double-stranded RNA-or virus-induced Proinflammatory response NF-kappaB regulation in the immune system IKK-1 and IKK-2: Cytokine-activated IkappaB kinases essential for NF-kappaB activation Global epidemiology of hepatitis B virus infection: New estimates of agespecific HBsAg seroprevalence and endemicity Time trends of chronic HBV infection over prior decades-A global analysis Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between Hepatitis B virus infection An overview of the immune system The role of interferon in cancer therapy: 99 HIV infected immune cells, including monocytes, lymphocytes, and macrophages, act as stable rival reservoirs, 100 and are main barrier to F I G U R E 2 MVP plays a pivotal role in the proinflammatory response caused by (−) ssRNA viral infection eradicate virus by antiviral therapy. keywords: antiviral; ap-1; binding; cancer; cells; chromosome; chronic; complex; cystatin; cytoplasm; dependent; diseases; dsrna; ebpβ; effect; expression; factor; fos; gene; global; hbsag; hbv; hcv; hepatitis; hev; hiv-1; host; human; iav; ifn; il-6; il-8; immune; important; induced; infected; infection; influenza; innate; interferon; jun; kinase; like; liver; macrophages; major; mvp; myd88; nuclear; pathway; patients; production; proinflammatory; protein; receptor; related; replication; resistance; response; rna; role; signal; silvestrol; stat-1; toll; transcription; treatment; type; vault; viral; viral infection; virus; viruses cache: cord-009813-o8ai730r.txt plain text: cord-009813-o8ai730r.txt item: #18 of 79 id: cord-010088-s9tfvtao author: None title: Oral Abstracts date: 2013-11-01 words: 43554 flesch: 46 summary: The information of blood donors with rare blood types is registered into the National Registering System for Blood Donors with Rare Blood Types by professional technician from organizations join the program. Present methods to recruit blood donors based on age, gender and occupation groups for a stable blood supply. keywords: absence; abstracts; accepted; accreditation; acid; activation; activities; activity; acute; addition; adverse; agents; aiha; aims; alleles; alloantibodies; allogeneic; amotosalen; analysis; anti; antibodies; antibody; antigens; apheresis; applied; approach; asian; assay; assessment; australia; autoimmune; availability; available; awareness; background; bacterial; basis; best; better; bleeding; blood; blood bank; blood cells; blood centers; blood collection; blood components; blood donation; blood donors; blood group; blood products; blood safety; blood samples; blood service; blood supply; blood transfusion; blood types; cardiac; care; cases; cause; cd36; cells; center; centre; chain; challenges; change; china; chinese; class; clear; clinical; collection; commercial; committee; common; complex; complications; concentrates; concentration; conclusion; conditions; consistent; contamination; continuous; control; cost; countries; country; criteria; critical; cross; cross blood; culture; current; data; day; days; deferral; deficient; definitions; demand; dengue; denv; detection; development; diagnosis; different; disease; distribution; dna; donations; drug; early; effective; effects; efficacy; eid; elisa; emm; errors; essential; established; events; example; expected; exposure; expression; facilities; factors; female; ffp; findings; focus; fold; following; fractionation; frequencies; frequency; frequent; fresh; function; future; gel; general; genotype; genotyping; global; goal; granulocyte; group; growth; guidelines; haemovigilance; hav; hbc; hbs; hbv; hcv; health; heparin; high; higher; history; hit; hiv; hla; hna; hospital; hpa; human; iat; identification; igg; immune; immunoglobulin; impact; implementation; important; improved; improvement; incidence; incidents; increase; india; individuals; induced; infected; infection; inflammatory; information; initial; injury; international; inventory; investigation; iron; isbt; itp; itregs; japan; japanese; jev; key; knowledge; laboratories; laboratory; large; lead; levels; likely; limited; local; long; loss; low; lower; lps; main; major; majority; male; management; measures; mechanism; medical; medicine; medium; methods; mice; model; molecular; monitoring; months; mortality; multiple; mutations; nait; national; national blood; necessary; need; negative; neutralizing; new; non; number; obi; observed; old; order; paper; particular; party; pathogen; patients; pbm; pcr; people; period; phase; phenotype; plasma; platelet; platelet antibodies; platelet donors; platelet transfusion; pmn; pmp; pool; population; positive; positive blood; possible; post; potential; practice; prepared; presence; present; presentation; prevalence; prior; procedures; process; processes; processing; production; products; programme; protein; prt; ptr; public; quality; range; rapid; rare blood; ratio; rbcs; rccs; reactions; reactive; recent; recipients; red; red blood; red cells; refractoriness; region; regional; registry; regulatory; related; relevant; remains; reported; reporting; reports; repository; requirements; research; residual; resources; response; results; review; risk; rmp; role; routine; safety; samples; screening; second; secondary; selection; self; sequencing; serological; serology; serum; service; severe; significant; similar; singapore; single; sites; skin; small; snp; society; specific; specificity; staff; standards; state; status; step; storage; strategies; strategy; students; studies; study; subtypes; sufficient; suitable; supernatant; support; surgery; surgical; symptoms; system; table; target; techniques; technologies; technology; term; terminology; tested; testing; tests; therapeutic; therapy; thrombocytopenia; time; tissue; tokyo; total; training; trali; transfusion; transfusion medicine; transfusion process; transfusion safety; transmission; treatment; types; understanding; units; university; untreated; use; useful; viral; virus; viruses; vitro; vivo; voluntary; washing; wnv; work; working; world; years cache: cord-010088-s9tfvtao.txt plain text: cord-010088-s9tfvtao.txt item: #19 of 79 id: cord-010092-uftc8inx author: None title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 words: 233543 flesch: 50 summary: One central question is the need of individual NAT screening (ID) versus minipool NAT screening (MP) approaches to identify all relevant viremias in blood donors. 3A-S02-03 Background: The screening of blood donors and returning travelers from active transmission areas have highlighted the importance of diagnosis of acute arboviral infections. keywords: /unit; aabb; abbott; abo blood; absence; abstract; accel; acceptable; access; accordance; account; accuracy; accurate; acid; activation; activities; activity; acute; addition; additive; adequate; adherence; adjusted; administration; admission; adsorption; adult; adverse; adverse reactions; adverse transfusion; aet; affected; african blood; age group; aged; agglutination; aggregation; agitation; agreement; ahg; aiha; aims; alert; algorithm; alinity; aliquots; allele; allergic; allergy; alloantibodies; alloantibody; allogeneic blood; allogeneic donors; alloimmunization; altered; alternative; american; amino; amotosalen; amounts; amplification; analysed; analysis; analytical; analyzer; anemia; annexin; annual; antenatal; anti; antibodies; antibody; antibody positive; antibody screening; antigen; antigen expression; antiglobulin; aop; apheresis; apheresis donors; apheresis platelet; apoptosis; apparent; application; applied; approach; appropriate; approval; april; architect; areas; arm; arms; array; arterial blood; arv; asia; aspects; assay; assessment; associated; association; assurance; asymptomatic; atp; atrs; attempt; attention; audit; august; australia; authorities; autoimmune; autologous blood; autologous donors; automated; availability; available; available blood; average; awareness; babesia; background; bacterial; bag; bags; balance; banks; baseline; basis; bcp; bct; bedside blood; beginning; behaviour; beneficial; benefit; best; beta; better; binding; bio; biological; biotin; bleeding; blood administration; blood background; blood bank; blood banking; blood cells; blood center; blood chimerism; blood collection; blood components; blood conservation; blood count; blood culture; blood demand; blood donation; blood donors; blood establishments; blood flow; blood gas; blood group; blood grouping; blood guide; blood haemoglobin; blood institute; blood loss; blood management; blood mixer; blood ordering; blood packs; blood plasma; blood platelet; blood pressure; blood processing; blood products; blood recipients; blood results; blood safety; blood samples; blood screening; blood sector; blood separation; blood services; blood specimens; blood supply; blood system; blood test; blood testing; blood transfusion; blood type; blood typing; blood units; blood utilization; blood volume; blood wastage; bombay; bone; breast; bsms; bts; buffy; burden; calcium; calculated; calculation; canada; cancer; capable; capacity; cardiac; cards; care; cases; categories; category; caucasian; cause; ccdee; cd177; cd34; cd36; cd38; cd62p; cell antibody; cell antigens; cell disease; cell donors; cell transfusion; cell units; cellular; centers; central blood; centre; centrifugation; certain; cfnas; cfu; chain; challenge; change; characteristics; characterization; characterized; check; chemotherapy; children; china; chinese blood; chronic; circulatory; classification; classified; clear; clinical; clinical data; clinical transfusion; clinicians; close; cmnc; cmv; coagulation; coat; coated; cobas; cobe; coding; coefficient; cohort; cold; collaboration; collagen; collected; collections; column; combination; combined; commercial; common; communication; community; comparable; comparative; compare; comparison; compatible blood; complement; complete; complete blood; completion; complex; compliance; complicated; complications; computer; concentrates; concentration; concern; conclusions; conditions; confirmation; confirmatory; confirmed; consecutive; consensus; consequences; considerable; consistent; constant; consumption; contact; contaminated blood; contamination; content; continued; continuous; contrast; control; control group; conventional; coombs; cord blood; correct; correlation; corresponding; cost; countries; country; counts; courses; coverage; cpp; criteria; critical; cross; crossmatch; crp; crucial; cryopreservation; cultured; current blood; curve; cytokines; cytometry; d antigen; d rhd; dae; daily; daily blood; daratumumab; data; data analysis; database; date; day; days; death; decades; december; decision; decreased; decreasing; deferral; deficiency; definitions; degree; delayed; deletion; delivery; demographic; density; department; dependent; descriptive; design; details; detectable; detection; determination; determined; developed; development; deviation; device; diagnosis; difference; different blood; differentiation; difficult; direct; discrepancies; discrepancy; disease; disorders; distribution; dmso; dna; dna samples; documentation; donating; donations; donor adverse; donor deferral; donor group; donor health; donor population; donor rbcs; donor red; donor return; donor safety; donor samples; donor screening; donor selection; doppler; dose; double; drms; drug; dubai blood; duffy blood; duration; e.g.; early; east; easy; economic; edel; edta; education; effect; effective; effective blood; effectiveness; efficacy; effort; elecsys; elective; electronic; elevated; eligibility; eligible; eligible donors; elisa; elution; emergency; encoding; end; endemic; english; enhancer; entire; environment; enzyme; epidemiological; epidemiology; episodes; equipment; errors; erythrocyte; essays; essential; established; estimate; estimation; etc; ethnicity; european; evaluation; events; evidence; examination; example; exchange; exon; expected; experience; experimental; experts; 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inflammatory; influence; information; informed; infusion; initial; injured; injury; inno; insight; institute; institution; instruments; intake; integrated; intensity; intensive; intention; interaction; intercept blood; interest; international; interpretation; interregional blood; interval; intervention; interviews; intravenous; introduction; intron; invasive; inventory; investigation; ipu; iqr; iranian blood; irish blood; iron; irradiated; irradiation; irregular; isbt; isolated; issue; itp; ivig; january; july; june; kazakhstan; kell; key; kir; kit; kits; knowledge; known; korean; label; labeling; laboratories; laboratory; lack; lactate; lapse; large; largest; later; lead; learning; length; leukemia; leukocyte; leukoreduced; levels; life; lifestyle; light; like; likely; limited; limiting; linear; literature; little; local; logistic; long; longer; low; low hb; lower; lowest; lps; lung; lutheran blood; machine; main; maipa; major; major blood; majority; making; mandatory; manner; manual; 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nurses; objective; observational; observed; occurrence; october; old; older blood; oncology; ongoing; online; operating; operational; operative; operators; opportunities; optia; optimal; optimal blood; option; oral; order; organ; organization; origin; outcomes; outside; overall; overload; oxidation; oxygen; p =; packed; pakistan; panel; papain; paper; parallel; parameters; partial; participants; particles; particular; particular blood; pas; past; pathogen; patient blood; patient safety; patients; patients samples; pattern; pbm; pbpc; pbsc; pcr; pcs; pdi; peak; pediatric; pediatric patients; people; percentage; performance; period; peripheral blood; personnel; pf4; phase; phenotype; physical; physicians; physiological; pilot; planned; plasma; plasma donation; plasma donors; plasma samples; plasma transfusion; plasma units; plasmapheresis; platelet; platelet antibodies; platelet antigens; platelet concentrates; platelet count; platelet donors; platelet function; platelet products; platelet storage; platelet transfusion; platelet units; platform; plt; plts; plus; pmet; point; policies; policy; polish blood; polymerase; polymorphisms; pooled; pooling; pools; poor; population; portugal; positive; positive anti; positive blood; positive donations; positive donors; positive group; positive patients; positive results; positive samples; positivity; possibility; possible; post; post transfusion; potassium; potential; potential donors; practical; practice; prbc; prc; precision; predictive; predictor; pregnancies; pregnancy; pregnant; pregnant blood; pregnant donors; preliminary; premedication; prenatal; preoperative; preparation; prepared; presence; present; present study; presentation; pretransfusion; prevalence; previous; previous blood; previous transfusion; prick; primary; primers; prior; prism; private blood; probability; problem; procedure; process; processed; production; profile; progenitor; program; programme; progress; project; proliferation; prolonged; promoter; proper; properties; prophylactic; prophylaxis; proportion; prospective; prospective blood; protein; protocol; provision; prp; prt; public; purpose; quality; quality blood; quantitative; questionnaire; questions; randomized; range; rapid; rare blood; rare donors; rate; rbc blood; rbc transfusion; rbc units; rbcs; rcc; rccs; reach; reactive; reactive blood; ready; reagents; reasons; recent; receptor; recipients; recombinant; recommendations; reconstitution; records; recovery; recruitment; red blood; red cell; red cross; reduced; reference; refractory; regional blood; regions; registered; regression; regular blood; regular donors; regulation; regulatory; rejection; related; relationship; relative; release; relevant; relevant blood; reliable; remote; remunerated blood; renal; repeat blood; repeat donors; replacement; replacement blood; reported; reporting; reports; reproductive; republic; request; require; requirements; research; residual; resistance; resource; respect; respiratory; respondents; response; responsible; restrictive; results; retention; retrospective; retrospective study; return; reveos; reveos blood; reverse; review; rh blood; rhce; rhd; rhd gene; rhd negative; rhd positive; rhdig; rhesus; rich; rise; risk; risk factors; risk patients; robust; roche; role; room; routine blood; russian; sagm; saharan; saline; sampling; sanger; sanguinis; sanquin blood; saving; scale; scd; scd patients; scenario; scientific; score; screening; season; second; second blood; secondary; sectional; selection; self; sensitive; sensitivity; sensitization; separate; september; sequence; sequencing; sera; serological; serology; seroprevalence; serum; set; setting; severe; severity; sex; sheep; shift; shock; short; shows; sickle; sigma; significant; significant blood; signs; similar; simple; single; single blood; sites; situation; size; skin; small; snp; snps; social; society; software; solid; soluble; solution; sources; south; spain; special; species; specific; specific blood; specificities; specificity; spectra; splice; split; spss; squ; square; src; ssp; stability; stable; staff; stakeholders; standard; standard blood; standardized; staphylococcus; start; starting; state; statistical; status; stem cell; step; stimulation; storage; storage period; storage time; stores; strains; strategies; strategy; strength; strong; structure; students; studies; study; study group; study period; subgroups; subjects; subsequent; substitutions; successful; sufficient; suitable; summary; supernatant; support; surface; surgery; surgical; surgical blood; surveillance; survey; survival; swirling; switzerland; symptoms; syndrome; syphilis; systematic; systems; t cell; ta6; ta7; taco; tacsi; tags; target; targeted; team; technical; technique; technologies; technology; temperature; temporary; terms; tertiary; terumo; test results; tested; testing; tests; thai blood; thalassemia; therapeutic; therapeutic blood; therapies; therapy; threats; threshold; thrombocytopenia; throughput; time donors; timely; times; tissues; titer; titre; tm blood; tool; total; total blood; total number; toxicity; tpe; tpo; traceability; training; trali; transcription; transfer; transfusion center; transfusion chain; transfusion data; transfusion events; transfusion guidelines; transfusion history; transfusion indications; transfusion institute; transfusion laboratory; transfusion management; transfusion medicine; transfusion models; transfusion policy; transfusion practice; transfusion process; transfusion protocol; transfusion reactions; transfusion recipients; transfusion results; transfusion safety; transfusion sample; transfusion service; transfusion strategies; transfusion support; transfusion testing; transfusion therapy; transfusion time; transfusion transmission; transfusions; transmission; transplantation; transpose; trauma; travel; treated; treatment; trend; trial; trigger; trima; true; ttis; tube; tumor; types; typing; uk blood; unclear; underlying; understanding; unique; united; universal; university; unknown; untreated; unusual; upper; uptake; usa; usage; use; useful; users; vaccination; valuable; value; variability; variables; variant; variation; varies; vasovagal; vector; vein; venous blood; version; versus; viral; virus; viruses; vitro; vivo; volumes; voluntary blood; vox; vvr; warm; washed; way; wb donors; wbc; wbd; weak; weak d; weeks; weight; western; wgs; white blood; wide; window; wnv; women; work; working; world; worldwide; wrong blood; years; yield; young; younger; zikv; à80 cache: cord-010092-uftc8inx.txt plain text: cord-010092-uftc8inx.txt item: #20 of 79 id: cord-010119-t1x9gknd author: None title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 words: 230433 flesch: 50 summary: Probability of occurrence of cannabis metabolites in blood donor samples is likely to be highly variable across donor centers and is largely dependent on blood donor demographics. OBRR, CBER, FDA Background/Case Studies: Extended molecular typing of a large number of blood donors can increase the likelihood of identifying donor red blood cells (RBCs) that match those of the recipient. keywords: -ipf; 1,2; 2,3; 48c; 68c; 7)-d; aabb; abbott; abc; ability; abnormal; abo; abo blood; absence; absent; absolute; abstract; academic; acceptable; accepted; access; account; accuracy; accurate; acid; acoustic; activated; activations; activities; actual; acute; acute blood; adamts13; additional; additional blood; additive; address; adequate; adherence; adhesion; adjusted; administration; admission; adsorption; adult; adverse; aes; affected; african; agglutination; aggregation; agreement; ahg; ahus; aid; aim; aims; ais; albumin; alert; algorithm; alinity; aliquots; alleles; allergic; alloantibodies; alloantibody; allogeneic blood; alloimmunization; allow; alpha; altered; alternative; alyx; american; amicus; amino; amotosalen; amplification; amsc; amustaline; analysis; analytical; analyzed; analyzers; anemia; annual; anova; anti; antibodies; antibody; antibody screen; antibody testing; antigen; antigen negative; antiglobulin; antisera; anwj; ap donors; apheresis; apheresis donors; apheresis platelet; apparent; application; applied; appointment; approach; appropriate; approval; april; aprp; ardp; areas; as-3; assay; assessment; associated; association; asymptomatic; at1rab; atp; audit; august; autoab; autoimmune; autologous; autologous blood; automated; automation; availability; available; average; average blood; awareness; away; b cells; babesia; baby; background; bacterial; bactx; bags; band; banks; baseline; basis; bbc; bct; beadchip; beads; bedside; benefit; best; better; bilirubin; biotin; birth; bis; bleeding; blood; blood bank; blood banking; blood cells; blood center; blood collection; blood components; blood count; blood cultures; blood donation; blood donors; blood drives; blood establishments; blood filtration; blood flow; blood fridge; blood group; blood grouping; 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cooler; copies; cord blood; corporation; correct; correlation; corresponding; cost; count; counter; counting; countries; country; course; coverage; criteria; critical; cross; crossmatch; crucial; cruzi; cryo; cryoprecipitate; cryopreservation; cryopreserved; culture; culture results; current; current blood; cutoff; cxcr5; cytometry; d antigen; d rhd; d35; daily; damage; dara; daratumumab; data; database; date; days; days post; death; december; decision; decline; decreased; deferral; deficiency; deglycerolization; dehp; delayed; delays; delivery; demand; demographic; density; department; dependent; depletion; derived; details; detectable; detection; determination; determined; determining; developed; development; deviation; device; diagnosis; differences; different; different blood; difficult; diluted; dilution; direct; discharged; discrepancies; discrepant; discussion; disease; disease patients; disorders; distinct; distribution; dmso; dna; documentation; donations; donor anti; donor center; donor plasma; donor population; donor samples; donor testing; donor units; dose; double; dpg; drug; dtt; duffy blood; duke; duration; e.g.; early; eastern; easy; echo; edta; edta blood; educational; effect; effective; effectiveness; efficacy; efficient; effort; electronic; electronic blood; elevated; eligibility; eligible; elisa; eluate; emergencies; emergency blood; emergent; emr; encode; encoding; end; endemic; engraftment; enhanced; enhancement; enrichment; entry; environment; enzyme; epidemic; episodes; equal; equipment; equivalent; errors; erythrocytes; erytra; esd; essential; established; estimated; etc; ethnic; ethnicity; etiology; europe; evaluation; events; evidence; evs; example; excellent; exchange; exchange transfusion; exclusion; existing; exon; expectations; expected; experience; experimental; expiration; expired; exposure; expression; extended; extensive; extent; external; extracellular; extraction; facilities; facility; factors; failure; false; family; faster; fda; feasible; february; feedback; female; female donors; ferritin; fetal; fetus; fewer; ffp; fibrinogen; ficin; filter; filtration; final; finding; flow; fluid; fluorescence; focused; fold; following; forming; forms; forward; foxp3; fraction; france; free; freezing; frequencies; frequency; frequent; fresh; frozen; frozen plasma; function; functionality; future; fviii; gamma; gaps; gel; gender; gene; general; generation; genetic; genomic; genotype; genotyping; george; given; glucose; glycine; gmbh; goal; good; grade; granulocyte; greater; grifols; group b; group o; group system; groups; growth; guidance; guidelines; gvhd; haemonetics; half; haplotype; haptoglobin; harm; hba1c; hbc; hbsag; hbv; hct; hcv; hdfn; hdn; health; healthcare; heart; help; hematocrit; hematologic; hematopoietic; hemoglobin; hemolysis; hemolytic transfusion; hemorrhage; hemostatic; hepatitis; heterozygous; hev; hgb; high; high blood; higher; highest; hips; hispanic; historical blood; history; hiv; hla; homozygous; hospital; hospital background; hospital blood; hospital transfusion; hospitalization; hours; hpa; hpa-1a; hpc; hsct; htlv; human; human blood; human plasma; hybrid; hypotension; iatrogenic blood; icu; ideal; identical; identification; identity; igg; igm; ih-1000; immature; immediate; immucor; immune; immunoassay; immunogenicity; immunoglobulin; immunohematology; impact; implementation; implicated; important; improved; improvement; inactivation; incidence; incident; incompatible; increased; increment; incubated; incubation; indeterminate; index; indications; indirect; individuals; induced; infants; infected; infection; inflammation; inflammatory; influence; information; infusion; inhibitor; initial; initiation; injury; inpatient; inr; institute; institution; instructions; instrument; integrity; intended; intensity; intensive; intercept blood; interface; interference; internal; international; intervals; intervention; intravenous; introduction; intron; invasive; inventory; investigation; ipc; irl; iron; irradiated; irradiated blood; irradiation; isolated; issues; issuing; ivig; james; january; jennifer; jka; july; june; kell; key; kidd; kidney; kit; knowledge; known; label; labeling; laboratories; laboratory; laboratory results; laboratory testing; labs; lack; lactate; lancet; large; later; lead; leading; lean; learning; length; lesion; leukapheresis; leukemia; leukocyte; leukoreduced; leukoreduction; levels; ley; licensed; life; light; likely; limitations; limited; limited blood; limits; linear; lipid; liquid; liss; list; literature; little; loads; local; location; locus; logistic; long; longer; low; lower; lowest; lps; lrap; luminex; lung; lymph; lymphocytes; lymphoma; main; maintenance; majority; making; malaria; males; manner; manual; manufacturer; manufacturing; march; markers; marrow; massive transfusion; matched; matching; materials; maternal; maternal blood; maximum; mayo; mds; mean; measured; measurement; mechanisms; median; medical; medical center; medicine background; medium; meeting; members; membrane; metabolism; method; methodology; metrics; mice; michael; microbial; microscopic; microti; migration; mild; milk; minimal; minimum; minor; minutes; mirasol; missing; mitigation; mixed; mmol; mns blood; mobilization; model; molecular; molecular testing; monitoring; monoclonal; monoclonal anti; monocytes; monthly; months; morbidity; morphology; mortality; mother; mouse; msbos; mscs; mtor; mtp; mtps; multidisciplinary; multiple; multiple blood; mutation; myeloma; n51; n52; national blood; nationwide; necessary; need; negative blood; negative donors; negative rbcs; negative results; neo; neonatal; neonates; new; new blood; new method; newborn; nip; non; norcross; normal; novel; november; nucleic; nucleotide; number; numerous; nurses; nursing; objective; observation; observed; obstetric; occurrence; october; odp; old; oncology; oneg; ongoing; online; onset; operations; operative; operator; opportunities; opportunity; optia; optimal; optimization; option; oral; order; organ; organisms; organization; original; orp; ortho; otii; outcomes; outdate; outpatient; outside; overall; overload; oxygen; p<0.001; p<0.05; packed; pag3c; pain; paired; pairs; pak; pancreatitis; panel; papain; paper; parallel; parameters; parasites; partial; participants; particular; pas; past; pathogen; pathology; patient blood; patient care; patient data; patient identification; patient outcomes; patient plasma; patient population; patient rbcs; patient safety; patient samples; patients; patterns; pbm; pbmcs; pbsc; pcc; pcr; pcs; pd1; peak; pediatric; pediatric patients; peg; people; percentage; performance; period; peripheral blood; personnel; phase; phenotype; phenotype results; phlebotomy; phone; physical; physicians; pilot; placental blood; plasma; plasma anti; plasma exchange; plasma platelets; plasma samples; plasma testing; plasma transfusion; plasma units; plasma volume; plasmapheresis; platelet; platelet blood; platelet collection; platelet concentrates; platelet count; platelet donors; platelet inventory; platelet products; platelet transfusion; platelet units; plateletpheresis; platform; plerixafor; pls; plt; plt units; plts; pmn; pms; point; policy; polyclonal; polymorphism; pooled; pools; poor; population; positive; positive antibody; positive rbcs; positive results; positive samples; possibility; possible; post; post transfusion; potassium; potential; potential blood; practice; prbc; pre; precision; predictive; pregnancy; pregnant; preliminary; prenatal; preoperative; preparation; prepared; presence; present; present study; presentation; pressures; prevalence; previous; previous study; primary; primed; prior; probable; probe; problem; procedure; process; processes; processing; processor; procleix; profile; program; project; proliferation; properties; prophylactic; proportion; prospective; protein; protocol; providers; providing; province; prp; prt; pss; pts; public; pulmonary; pump; purpose; purpura; qualified blood; quality; quantitative; questionnaire; questions; random blood; randomized; range; rapid; rare; rare blood; rare donor; raritan; rate; ratios; rbc; rbc antibody; rbc antigens; rbc blood; rbc products; rbc samples; rbc storage; rbc transfusion; rbc units; rbc use; rbcs; rccs; rcf; reactive; reactive samples; reactivity; reagent; real; reasons; receipt; receiving; recent; recipients; recognized; recommendations; record; recovered; recovery; recruitment; recurrent; red blood; red cell; red cross; reduced; reduction; reference; refractoriness; refractory; regional blood; regions; regression; regular; regular blood; regulations; regulatory; rejection; rejuvenation; related; relationship; relative; release; relevant; reliable; remote blood; removal; removed; repeat; replacement; replicates; reported; reporting; reports; request; requirements; research; residents; residual; resolved; resources; respiratory; respondents; responder; response; responsible; results; resuscitation; retention; retrospective; retrospective study; return; reverse; review; revised; rflp; rh blood; rh(-; rhce; rhce*ce; rhd; rhd*diiia; rhig; rich; rise; risk; rna; robust; role; room; routine; routine blood; rrbc; rrv; rule; run; runs; sagm; saline; sample results; sampling; sandra; sanger; sanquin; saturation; savings; scale; scale blood; scd; scd patients; schedule; school; scientific; score; scott; screening; screens; sdp; second; secondary; secure; seeded; segment; selected; selection; sensitive; sensitivity; sensitization; separate; sepsis; september; septic; sequence; sequencing; series; seroconversion; serologic; serology; serum; session; set; sets; setting; severe; severity; sex; shelf; shock; short; shorter; shows; sickle; sieving; signal; significant; significant blood; signs; similar; similar results; simple; simulated; simulated transfusion; simulation; singapore; single; site; situations; size; size blood; small; smaller; snmvs; snp; snps; software; solid; solution; source; south; spc; spdp; special; species; specific; specifications; specificity; spectra; speed; spiked; spin; spleen; split; square; ssp; ssrbcs; stability; staff; stakeholders; standard; standard blood; standardized; starting; states; statistical; stay; stem cell; steps; sterile; storage; strategies; strategy; strength; strong; strs; students; study design; study group; study period; study population; subjects; subsequent; subset; substantial; substitution; successful; suitable; summer; supernatant; supplement; support; suppression; surface; surgeries; surgery; surgical blood; surveillance; survey; survival; susan; sxs; symptoms; syndrome; syringe; sysmex; systems; t cells; t&s; table; taco; taiwan; target; targeted; tasks; tattoo; team; technical; technique; technologists; technology; temperature; terms; tertiary; terumo; test results; tested; testing; testing method; testing time; tests; tetanus; tgf; thalassemia; thawed; thawing; therapeutic; therapeutic plasma; therapy; threshold; thrombin; thrombocytopenia; thrombotic; throughput; time; time donors; time period; time studies; time study; timely; tissue; titer; titer anti; titer results; tma; tms; tool; total; total blood; total number; total plasma; toxicity; tpe; tracking; traditional; training; trali; tranexamic; transfer; transfused; transfusion center; transfusion data; transfusion guidelines; transfusion laboratory; transfusion management; transfusion medicine; transfusion practice; transfusion process; transfusion protocol; transfusion quality; transfusion reactions; transfusion recipients; transfusion results; transfusion safety; transfusion sample; transfusion service; transfusion strategies; transfusion study; transfusion support; transfusion testing; transfusion therapy; transfusion transmission; transfusion volume; transfusion yield; transfusions; transmission; transplant; transplantation; transport; trauma; trauma patients; travel; treatment; tregs; trend; trial; triglyceride; trima; true; ttp; ttp patients; tube; tube method; tumor; turnaround; txa; txs; types; typing; typing results; u.s; ucb; underlying; understanding; underwent; unique; unit transfusion; united; units; universal; universal blood; university; unknown; unrelated; untreated; urgent; urine; usage; use; useful; users; uv1r; uva; vaccination; vaccine; validation; values; variable; variants; variations; varied; vein; venous; venous blood; verification; version; viability; viable; viral; virtuo; virus; viruses; vision; visual; vitro; vivo; volumes; voluntary blood; volunteers; vs.; vvr; vwf; waiha; walk; warm; washed; washing; wastage; waste; way; wbc; wbcs; wbd; wbf; weak; weak d; weekly; weeks; weight; white blood; wide; williams; window; women; work; workflow; working; workload; workup; world; wrong blood; x10; yale; year; yfv; yield; young; zealand blood; zika; zikv; zkv; zpp cache: cord-010119-t1x9gknd.txt plain text: cord-010119-t1x9gknd.txt item: #21 of 79 id: cord-015941-4fz79wzf author: Hu, Yuan title: Molecular Techniques for Blood and Blood Product Screening date: 2018-11-10 words: 7210 flesch: 47 summary: Detection of early HBV infection of blood donors is still a major problem of blood transfusion. Section two: Specific virus families Evaluation of a prototype Trypanosoma cruzi antibody assay with recombinant antigens on a fully automated chemiluminescence analyzer for blood donor screening Transfusion-transmitted malaria in countries where malaria is endemic: a review of the literature from sub-Saharan Africa Detection and species identification of malaria parasites by isothermal tHDA amplification directly from human blood without sample preparation 18 years of research and surveillance Prions: beyond a single protein Crerutzfeldt-Jakob disease and blood transfusion: updated results of the UK transfusion medicine epidemiology review study Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay Preclinical detection of variant CJD and BSE prions in blood Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion Analytical and clinical performance of the CDC real time RT-PCR assay for detection and typing of dengue virus Threat of dengue to blood safety in dengueendemic countries Comparison of a commercial IgM capture ELISA with dengue antigen focus reduction microneutralization test and the centers for disease control dengue IgM capture-ELISA PCR detection of nearly any dengue virus strain using a highly sensitive primer cocktail Do babesiosis and malaria share a common disease process? Babesia: a world emerging Babesia infection through blood transfusions: reports received by the US Food and Drug Administration Transfusion-transmitted Babesia spp.: keywords: acid; agents; amplification; amplifying; antibodies; antibody; antigens; assay; available; babesia; babesiosis; blood; cases; cause; cell; chagas; chronic; clinical; cmv; commercial; confirmatory; cruzi; current; dengue; detection; diagnosis; disease; dna; donors; early; elisa; field; genetic; hbsag; hbv; hcv; hepatitis; high; hiv; htlv; human; important; infected; infection; liver; malaria; methods; microarray; molecular; nat; need; negative; new; non; nucleic; patients; pcr; people; period; polymerase; positive; potential; products; quantitative; reaction; real; recent; risk; rna; safety; sars; screening; sensitive; sensitivity; sequence; serologic; serum; specific; states; supply; techniques; technologies; technology; testing; tests; time; transfusion; transmission; ttv; united; viral; virus; viruses; weeks; window; wnv; years cache: cord-015941-4fz79wzf.txt plain text: cord-015941-4fz79wzf.txt item: #22 of 79 id: cord-016704-99v4brjf author: Nicholson, Felicity title: Infectious Diseases: The Role of the Forensic Physician date: 2005 words: 14642 flesch: 55 summary: In 1998, 56% of reported cases were from people born outside the United Kingdom and 3% were associated with HIV infection (70, 71) . Clusters of skin infections with MRSA have been reported among injecting drug users (IDUs) since 1981 in America (45, 46) , and more recently, similar strains have been found in the United Kingdom in IDUs in the community (47) . keywords: acute; adults; africa; age; agent; aids; approx; asymptomatic; aureus; available; bedding; bites; blood; body; care; cases; cell; chicken; children; chronic; clinical; close; clothing; common; complications; contact; contaminated; control; countries; course; custody; data; days; department; detainee; disease; dose; drug; early; east; eggs; end; estimated; exposure; fluids; following; forensic; gloves; group; hands; hav; hbv; hcv; health; hepatitis; high; higher; hiv; hospital; hours; human; idus; illness; immunocompromised; increased; incubation; individuals; infected; infection; information; injuries; intravenous; involved; kingdom; lesions; likely; liver; management; medical; member; mild; months; mouth; mucous; need; new; nonimmune; old; onset; open; outbreak; patients; people; period; person; phase; physician; population; positive; possible; pox; pregnant; present; prevalence; prevention; prolonged; rash; report; resistant; respiratory; risk; route; sars; scabies; severe; sexual; shingles; signs; site; skin; specific; spread; staff; states; symptoms; time; transmission; treatment; tuberculosis; united; united kingdom; use; users; vaccination; vaccine; varicella; victim; viral; virus; weeks; women; world; wounds; years; zoster cache: cord-016704-99v4brjf.txt plain text: cord-016704-99v4brjf.txt item: #23 of 79 id: cord-017012-yl0vanuh author: Herberg, Jethro title: Infectious Diseases and the Kidney date: 2009 words: 23989 flesch: 30 summary: Bacterial infections associated with renal disease and the likely mechanisms causing renal dysfunction are shown in > Impaired renal function is a common occurrence in systemic sepsis (1) . The group A streptococci (GAS) are a major worldwide cause of renal disease, usually as poststreptococcal nephritis. keywords: activation; acute; acute renal; addition; administration; adults; affected; africa; agents; allograft; antibiotic; antibodies; antibody; antigens; antiviral; apsgn; areas; associated; association; asymptomatic; bacterial; beta; biopsy; bkv; blood; capillary; cases; cause; cells; changes; childhood; children; chronic; circulation; clinical; cmv; coli; combination; common; complement; complexes; complication; congenital; countries; course; creatinine; damage; days; dengue; deposition; deposits; developed; development; diagnosis; dialysis; different; diffuse; direct; disease; disorder; distribution; dysfunction; early; effective; effects; electron; elevated; endocarditis; endothelial; epithelial; evidence; exposure; factors; falciparum; family; features; fever; findings; focal; forms; fulminant; function; gas; glomerular; glomerulonephritis; glomerulosclerosis; good; group; hbsag; hbv; hcv; hematuria; hemolytic; hemorrhagic; hepatic; hepatitis; high; histologic; hiv; hivan; human; hus; hypertension; hypovolemia; iga; igg; igm; illness; immune; immunocompromised; immunodeficiency; immunoglobulin; impairment; important; incidence; induced; infants; infected; infection; inflammatory; initial; injury; intensive; interferon; interstitial; intravenous; invasive; involvement; kidney; late; leptospirosis; lesions; levels; likely; liver; low; major; malaria; management; manifestations; mechanisms; membrane; meningococcal; mesangial; mgn; microscopy; mild; months; mortality; mountain; mpgn; necrosis; nephritis; nephropathy; nephrotic; nephrotic syndrome; normal; oliguria; onset; organisms; outcome; pathogenesis; pathophysiology; patients; pcr; pediatric; persistent; phase; plasma; pneumoniae; population; positive; prerenal; presence; present; primary; prognosis; proliferative; proportion; proteinuria; pulmonary; range; rash; recent; recipients; recovery; renal; renal biopsy; renal disease; renal failure; renal function; renal involvement; renal syndrome; renal transplant; renal transplantation; replacement; reported; reports; respiratory; response; results; review; ribavirin; risk; rocky; role; salmonella; secondary; segmental; sepsis; septic; serum; severe; severe cases; shock; shock syndrome; significant; similar; skin; specific; spread; stage; staphylococcal; states; strains; streptococcal; studies; study; support; symptoms; syndrome; systemic; therapy; thrombocytopenia; toxic; tract; transplant; transplantation; treatment; tubular; tubules; tubulointerstitial; united; urinary; urine; varicella; vasculitis; viral; virus; virus infection; viruses; volume; weeks; worldwide; years; yersinia cache: cord-017012-yl0vanuh.txt plain text: cord-017012-yl0vanuh.txt item: #24 of 79 id: cord-017948-fqhl1qb4 author: Hu, Yuan title: Molecular Techniques for Blood and Blood Product Screening date: 2012-04-05 words: 7305 flesch: 51 summary: Diagnosis depends upon fi nding parasites on blood fi lm examination which can be detected 2-4 weeks after a tick bite. Detection of early HBV infection of blood donors is still a major problem of blood transfusion. keywords: acid; agents; ampli; antibodies; antibody; antigens; assay; available; babesia; babesiosis; blood; cases; cation; cause; chagas; chronic; clinical; cmv; con; current; dengue; detection; diagnosis; disease; dna; donors; early; eld; fda; hbsag; hbv; hcv; hepatitis; high; hiv; htlv; human; hybridization; identi; important; infected; infection; liver; malaria; methods; molecular; nat; need; negative; new; nucleic; patients; pcr; people; period; positive; products; quantitative; reaction; real; recent; regulatory; requirements; risk; rmatory; rna; safety; sars; screening; sensitive; sensitivity; sequence; serologic; speci; states; supply; techniques; technology; testing; tests; time; transfusion; transmission; ttv; united; vcjd; viral; virus; viruses; window; wnv; world; years cache: cord-017948-fqhl1qb4.txt plain text: cord-017948-fqhl1qb4.txt item: #25 of 79 id: cord-022607-34hj17sn author: Wain‐Hobson, Simon title: Editing HBV into oblivion date: 2004-11-24 words: 3955 flesch: 44 summary: Viral mutants (altered peptide ligands) emerging in vivo have been associated with modulation of cytokine secretion of T cells. One possible message from this study is that T cells in HCV appear to be able to adapt in the face of a persisting virus, and in doing so modulate the intrahepatic environment to one that is less inflammatory (Fig. 1) . keywords: activity; acute; analysis; antigen; antiviral; apobec3; blood; cases; cd4; cd8; cd8ϩ; cells; chronic; cytidine; cytokine; dna; editing; expression; gene; hbv; hcv; hepatitis; hiv; human; hypermutants; hypermutation; ifn-; il-10; immune; infected; infection; intrahepatic; liver; low; molecules; overall; patients; populations; protein; replication; residues; responses; restriction; retroviruses; reverse; rna; role; secretion; single; specific; strand; study; t cells; viral; virus cache: cord-022607-34hj17sn.txt plain text: cord-022607-34hj17sn.txt item: #26 of 79 id: cord-023346-8sqbqjm1 author: None title: MONDAY: POSTERS date: 2005-06-08 words: 130150 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: 0.001; abbott; abc; abo blood; absence; accepted; access; accreditation; accurate; acid; activation; activities; activity; actual; acute; additional; adequate; administration; adsorptions; adults; adverse; affected; affinity; aged; agglutination; aim; aims; albumin; alert; allele; alloantibodies; alloantibody; allogeneic blood; alloimmunization; alternative; amplification; analysed; analysis; analyze; anemia; anti; anti hcv; antibodies; antibody; antigens; antiglobulin; apheresis; application; applied; approach; appropriate; area; asked; assay; assessment; associated; association; assurance; atp; autoimmune; autologous blood; automated; automation; availability; available; average; b19; background; bacterial; bag; bags; base; baseline; basis; baxter; benefit; best; beta; better; binding; birth; bleeding; blood bag; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood conservation; blood consumption; blood derivatives; blood donation; blood donors; blood establishments; blood filtration; blood flow; blood group; blood grouping; blood inventory; blood loss; blood management; blood parameters; blood plasma; blood platelet; blood pressure; blood products; blood safety; blood samples; blood service; blood shortage; blood supply; blood system; blood testing; blood transfusion; blood units; blood use; blood volume; bone; bts; buffy; cancer; capacity; cardiac; cards; care; cases; categories; category; caucasian; cause; ccdee; cd34; cde; cell patients; cell transfusion; cellular; centers; central; centre; centrifugation; certain; cfu; chain; changes; characteristics; children; chronic; circulation; class; clinical; clinicians; close; cmv; coagulation; coat; cold; collaboration; collected; collections; column; combination; combined; commercial; common; comparison; compatible; compatible blood; complement; complete; complex; compliance; complications; concentrates; concentration; concerned; concerns; conclusion; conditions; confirmed; consequence; considerable; consideration; considered; consumption; contamination; content; continuous; contrast; control; control group; conventional; coombs; cord blood; core; corrective; correlation; cost; council; count; counting; countries; country; course; criteria; critical; croatia; cross; crossmatch; csf; culture; current; cytokines; cytometry; d type; d+ blood; daily; data; date; day; days; december; decision; decrease; deferrals; deferred; degree; delayed; delivery; department; depletion; design; detailed; detectable; detection; determination; determined; development; device; diagnosis; diamed; differences; different; different anti; different blood; difficult; direct; directive; disaster; discussion; disease; disorders; distribution; dna; doctors; donations; donor cells; dose; double; drugs; duration; e.g.; early; easy; ebds; education; effect; effective; effective blood; effectiveness; efficacy; efficient; efforts; eia; elasticity; elements; elimination; elisa; end; environment; enzyme; equal; equipment; errors; erythrocytes; essential; established; estimated; etc; european; european blood; evaluation; events; evidence; excessive; exchange; exclusion; exons; expected; experience; exposure; expression; external; extraction; factor; failure; false; family; febrile; female; female blood; female donors; ferritin; fetal; fetus; ffp; fibrinogen; filter; filtration; final; findings; flow; fluorescence; focus; following; fractionation; france; free; freezing; frequency; frequent; fresh; fresh blood; frozen; function; future; g'max; gamma; gel; general; generation; genes; genetic; genotype; genotyping; gestation; glucose; goal; good; graft; granulocyte; greater; greece; group system; groups; growth; guidelines; gvhd; h63d; haematological; haemolysis; haemovigilance; half; hbc; hbsag; hbv; hcv; hcv antibodies; hdn; health; help; hematocrit; hematology; hematopoietic; hemocue; hemoglobin; hemolytic; hemolytic transfusion; hemorrhage; heparin; hepatitis; heterozygous; high; high blood; higher; history; hiv; hla; homologous blood; homozygous; hospital; hospital blood; hospital transfusion; host; hours; hpa; hpa-1a; hsr; htlv; human; human blood; i.v; identification; igg; igm; il-10; ill; immediate; immune; immunization; immunoassay; immunoglobulin; impact; implementation; important; improved; improvement; incidence; incompatibility; incorrect blood; increased; increasing; incubated; incubation; independent; independent blood; index; indications; indirect; individuals; infants; infected; infections; inflammatory; influence; information; informed; infusion; inhabitants; initial; injury; institute; institutions; insufficient; integrated; intensive; intercept blood; internal; international; intervention; intravenous; introduction; intron; investigation; involved; iron; irradiated; irradiation; irregular; isolated; issue; ivig; january; jka; kell; kidd; kit; knowledge; known; labile blood; laboratories; laboratory; lack; lactate; large; law; lead; leucodepleted; leucodepletion; leukocyte; level; life; light; like; likely; limited; liss; literature; load; local; local blood; long; lots; low; lower; lst1; magnetic; main; maintenance; major; major blood; majority; males; malignant; management; mandatory; manual; manufacturing; markers; marrow; massive; material; maximum; mbl; mcmv; mds; mean; measured; measurements; mechanisms; median; medical; medium; membrane; metabolic; methods; microplate; mild; ministry; minutes; mmol; mnc; model; modified; mods; molecular; molecules; monitoring; monoclonal; monoclonal anti; months; morbidity; mortality; mother; multiple; multiple blood; mutation; n =; national blood; necessary; need; negative; negative blood; neonatal; new; new blood; new donors; newborn; non; normal; nucleic; number; objective; observation; observed; occurrence; old; ones; operations; optimal; order; organization; ortho; outcome; overall; oxygen; p =; pabd; packed; pall; panels; parameters; partial; participants; particular; past; pathogen; pathway; patients; patients anti; patients blood; pcr; pcs; people; percentage; performance; period; peripheral blood; personal; personnel; phase; phenotype; physical; physicians; place; plasma; plasma samples; plasma transfusion; plasma units; plasmapheresis; platelet; platelet concentrates; platelet count; platelet products; platelet quality; platelet storage; platelet transfusion; plt; point; policy; polish blood; polyclonal; pooled; pools; poor; population; positive; positive antibody; positive blood; positive cells; positive control; positive donors; positive patients; positive results; positive samples; positivity; possibility; possible; post; post transfusion; postoperative; potential; practice; practitioners; predonation; pregnancies; pregnancy; pregnant; preliminary; premature; preoperative; preparation; prepared; presence; present; prevalence; prevention; previous; primary; principles; prior; prism; problem; procedure; process; processes; processing; procleix; professional; program; programme; project; proper; prophylactic; proportion; prospective; protection; protein; protocol; pth; public; pulmonary; purpose; quality; quality blood; quality control; quality system; quantitative; questionnaire; questions; rabbits; random; randomized; range; rapid; rare; rare blood; rbc; rbc transfusion; rbcs; rccs; rcts; reactive; reagents; real; reasons; recent; recipients; recombinant; recommendations; recovery; red blood; red cell; reduced; reduction; reference; regional blood; regions; regular; regular blood; regulations; regulatory; related; relative; release; relevant; reliable; removal; repeat blood; replacement; reported; reporting; reports; republic; required; requirements; research; residual; resources; respect; respiratory; response; responsible; restrictive; results; retrospective; reverse; review; rhd; rhesus; risk; rna; roche; role; room; routine; routine blood; run; sampling; scansystem; scientific; screened; screening; second; security; selection; self; sensitive; sensitivity; separator; sepsis; sequence; sera; serbia; seroconversion; serological; serology; serum; services; set; setting; severe; severity; sex; shock; short; shows; sickle; significant; signs; similar; simple; singapore; single; site; situations; size; small; society; software; solution; source; special; specific; specific antibodies; specific blood; specificity; specimens; srbc; ssp; staff; standard; state; statistical; status; step; storage; strategies; strategy; students; studies; study; study blood; subjects; subsequent; subsequent blood; successful; suffering; suggested; summary; support; surface; surgery; surgery patients; surgical; survey; survival; symptoms; syndrome; syphilis; system; system antibodies; table; target; technical; technique; technology; temperature; temporary; test; test results; tested; testing; thalassemia; therapeutic; therapy; thrombin; thrombocytopenia; throughput; time blood; time donors; times; titer; titre; tool; total; training; trali; transfusion center; transfusion hepatitis; transfusion medicine; transfusion policy; transfusion practice; transfusion reactions; transfusion safety; transfusion service; transfusion system; transfusion testing; transfusion therapy; transfusions; transmission; transplantation; transport; trauma; trauma patients; treated; treatment; trend; trials; trigger; trima; tube; tumor; turkey; type; typing; ultrio; understanding; underwent; unique; university; unpaid blood; unrelated; usage; use; useful; validation; value; variable; vascular; venous blood; viability; viii; viral; virus; viruses; vitro; vivo; voluntary blood; volunteers; washed; way; wbc; weak; weak d; weeks; weight; white blood; wide; window; women; work; working; world; years; yield; young; ° c cache: cord-023346-8sqbqjm1.txt plain text: cord-023346-8sqbqjm1.txt item: #27 of 79 id: cord-023354-f2ciho6o author: None title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 words: 130154 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: 0.001; abbott; abc; abo blood; absence; accepted; access; accreditation; accurate; acid; activation; activities; activity; actual; acute; additional; adequate; administration; adsorptions; adults; adverse; affected; affinity; aged; agglutination; aim; aims; albumin; alert; allele; alloantibodies; alloantibody; allogeneic blood; alloimmunization; alternative; amplification; analysed; analysis; analyze; anemia; anti; anti hcv; antibodies; antibody; antigens; antiglobulin; apheresis; application; applied; approach; appropriate; area; asked; assay; assessment; associated; association; assurance; atp; autoimmune; autologous blood; automated; automation; availability; available; average; b19; background; bacterial; bag; bags; base; baseline; basis; baxter; benefit; best; beta; better; binding; birth; bleeding; blood bag; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood conservation; blood consumption; blood derivatives; blood donation; blood donors; blood establishments; blood filtration; blood flow; blood group; blood grouping; blood inventory; blood loss; blood management; blood parameters; blood plasma; blood platelet; blood pressure; blood products; blood safety; blood samples; blood service; blood shortage; blood supply; blood system; blood testing; blood transfusion; blood units; blood use; blood volume; bone; bts; buffy; cancer; capacity; cardiac; cards; care; cases; categories; category; caucasian; cause; ccdee; cd34; cde; cell patients; cell transfusion; cellular; centers; central; centre; centrifugation; certain; cfu; chain; changes; characteristics; children; chronic; circulation; class; clinical; clinicians; close; cmv; coagulation; coat; cold; collaboration; collected; collections; column; combination; combined; commercial; common; comparison; compatible; compatible blood; complement; complete; complex; compliance; complications; concentrates; concentration; concerned; concerns; conclusion; conditions; confirmed; consequence; considerable; consideration; considered; consumption; contamination; content; continuous; contrast; control; control group; conventional; coombs; cord blood; core; corrective; correlation; cost; council; count; counting; countries; country; course; criteria; critical; croatia; cross; crossmatch; csf; culture; current; cytokines; cytometry; d type; d+ blood; daily; data; date; day; days; december; decision; decrease; deferrals; deferred; degree; delayed; delivery; department; depletion; design; detailed; detectable; detection; determination; determined; development; device; diagnosis; diamed; differences; different; different anti; different blood; difficult; direct; directive; disaster; discussion; disease; disorders; distribution; dna; doctors; donations; donor cells; dose; double; drugs; duration; e.g.; early; easy; ebds; education; effect; effective; effective blood; effectiveness; efficacy; efficient; efforts; eia; elasticity; elements; elimination; elisa; end; environment; enzyme; equal; equipment; errors; erythrocytes; essential; established; estimated; etc; european; european blood; evaluation; events; evidence; excessive; exchange; exclusion; exons; expected; experience; exposure; expression; external; extraction; factor; failure; false; family; febrile; female; female blood; female donors; ferritin; fetal; fetus; ffp; fibrinogen; filter; filtration; final; findings; flow; fluorescence; focus; following; fractionation; france; free; freezing; frequency; frequent; fresh; fresh blood; frozen; function; future; g'max; gamma; gel; general; generation; genes; genetic; genotype; genotyping; gestation; glucose; goal; good; graft; granulocyte; greater; greece; group system; groups; growth; guidelines; gvhd; h63d; haematological; haemolysis; haemovigilance; half; hbc; hbsag; hbv; hcv; hcv antibodies; hdn; health; help; hematocrit; hematology; hematopoietic; hemocue; hemoglobin; hemolytic; hemolytic transfusion; hemorrhage; heparin; hepatitis; heterozygous; high; high blood; higher; history; hiv; hla; homologous blood; homozygous; hospital; hospital blood; hospital transfusion; host; hours; hpa; hpa-1a; hsr; htlv; human; human blood; i.v; identification; igg; igm; il-10; ill; immediate; immune; immunization; immunoassay; immunoglobulin; impact; implementation; important; improved; improvement; incidence; incompatibility; incorrect blood; increased; increasing; incubated; incubation; independent; independent blood; index; indications; indirect; individuals; infants; infected; infections; inflammatory; influence; information; informed; infusion; inhabitants; initial; injury; institute; institutions; insufficient; integrated; intensive; intercept blood; internal; international; intervention; intravenous; introduction; intron; investigation; involved; iron; irradiated; irradiation; irregular; isolated; issue; ivig; january; jka; kell; kidd; kit; knowledge; known; labile blood; laboratories; laboratory; lack; lactate; large; law; lead; leucodepleted; leucodepletion; leukocyte; level; life; light; like; likely; limited; liss; literature; load; local; local blood; long; lots; low; lower; lst1; magnetic; main; maintenance; major; major blood; majority; males; malignant; management; mandatory; manual; manufacturing; markers; marrow; massive; material; maximum; mbl; mcmv; mds; mean; measured; measurements; mechanisms; median; medical; medium; membrane; metabolic; methods; microplate; mild; ministry; minutes; mmol; mnc; model; modified; mods; molecular; molecules; monitoring; monoclonal; monoclonal anti; months; morbidity; mortality; mother; multiple; multiple blood; mutation; n =; national blood; necessary; need; negative; negative blood; neonatal; new; new blood; new donors; newborn; non; normal; nucleic; number; objective; observation; observed; occurrence; old; ones; operations; optimal; order; organization; ortho; outcome; overall; oxygen; p =; pabd; packed; pall; panels; parameters; partial; participants; particular; past; pathogen; pathway; patients; patients anti; patients blood; pcr; pcs; people; percentage; performance; period; peripheral blood; personal; personnel; phase; phenotype; physical; physicians; place; plasma; plasma samples; plasma transfusion; plasma units; plasmapheresis; platelet; platelet concentrates; platelet count; platelet products; platelet quality; platelet storage; platelet transfusion; plt; point; policy; polish blood; polyclonal; pooled; pools; poor; population; positive; positive antibody; positive blood; positive cells; positive control; positive donors; positive patients; positive results; positive samples; positivity; possibility; possible; post; post transfusion; postoperative; potential; practice; practitioners; predonation; pregnancies; pregnancy; pregnant; preliminary; premature; preoperative; preparation; prepared; presence; present; prevalence; prevention; previous; primary; principles; prior; prism; problem; procedure; process; processes; processing; procleix; professional; program; programme; project; proper; prophylactic; proportion; prospective; protection; protein; protocol; pth; public; pulmonary; purpose; quality; quality blood; quality control; quality system; quantitative; questionnaire; questions; rabbits; random; randomized; range; rapid; rare; rare blood; rbc; rbc transfusion; rbcs; rccs; rcts; reactive; reagents; real; reasons; recent; recipients; recombinant; recommendations; recovery; red blood; red cell; reduced; reduction; reference; regional blood; regions; regular; regular blood; regulations; regulatory; related; relative; release; relevant; reliable; removal; repeat blood; replacement; reported; reporting; reports; republic; required; requirements; research; residual; resources; respect; respiratory; response; responsible; restrictive; results; retrospective; reverse; review; rhd; rhesus; risk; rna; roche; role; room; routine; routine blood; run; sampling; scansystem; scientific; screened; screening; second; security; selection; self; sensitive; sensitivity; separator; sepsis; sequence; sera; serbia; seroconversion; serological; serology; serum; services; set; setting; severe; severity; sex; shock; short; shows; sickle; significant; signs; similar; simple; singapore; single; site; situations; size; small; society; software; solution; source; special; specific; specific antibodies; specific blood; specificity; specimens; srbc; ssp; staff; standard; state; statistical; status; step; storage; strategies; strategy; students; studies; study; study blood; subjects; subsequent; subsequent blood; successful; suffering; suggested; summary; support; surface; surgery; surgery patients; surgical; survey; survival; symptoms; syndrome; syphilis; system; system antibodies; table; target; technical; technique; technologies; technology; temperature; temporary; test; test results; tested; testing; thalassemia; therapeutic; therapy; thrombin; thrombocytopenia; throughput; time blood; time donors; times; titer; titre; tool; total; training; trali; transfusion center; transfusion hepatitis; transfusion medicine; transfusion policy; transfusion practice; transfusion reactions; transfusion safety; transfusion service; transfusion system; transfusion testing; transfusion therapy; transfusions; transmission; transplantation; transport; trauma; trauma patients; treated; treatment; trend; trials; trigger; trima; tube; tumor; turkey; type; typing; ultrio; understanding; underwent; unique; university; unpaid blood; unrelated; usage; use; useful; validation; value; variable; vascular; venous blood; viability; viii; viral; virus; viruses; vitro; vivo; voluntary blood; volunteers; washed; way; wbc; weak; weak d; weeks; weight; white blood; wide; window; women; work; working; world; years; yield; young; ° c cache: cord-023354-f2ciho6o.txt plain text: cord-023354-f2ciho6o.txt item: #28 of 79 id: cord-023364-ut56gczm author: None title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 words: 130157 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: 0.001; abbott; abc; abo blood; absence; accepted; access; accreditation; accurate; acid; activation; activities; activity; actual; acute; additional; adequate; administration; adsorptions; adults; adverse; affected; affinity; aged; agglutination; aim; aims; albumin; alert; allele; alloantibodies; alloantibody; allogeneic blood; alloimmunization; alternative; amplification; analysed; analysis; analyze; anemia; anti; anti hcv; antibodies; antibody; antigens; antiglobulin; apheresis; application; applied; approach; appropriate; area; asked; assay; assessment; associated; association; assurance; atp; autoimmune; autologous blood; automated; automation; availability; available; average; b19; background; bacterial; bag; bags; base; baseline; basis; baxter; benefit; best; beta; better; binding; birth; bleeding; blood bag; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood conservation; blood consumption; blood derivatives; blood donation; blood donors; blood establishments; blood filtration; blood flow; blood group; blood grouping; blood inventory; blood loss; blood management; blood parameters; blood plasma; blood platelet; blood pressure; blood products; blood safety; blood samples; blood service; blood shortage; blood supply; blood system; blood testing; blood transfusion; blood units; blood use; blood volume; bone; bts; buffy; cancer; capacity; cardiac; cards; care; cases; categories; category; caucasian; cause; ccdee; cd34; cde; cell patients; cell transfusion; cellular; centers; central; centre; centrifugation; certain; cfu; chain; changes; characteristics; children; chronic; circulation; class; clinical; clinicians; close; cmv; coagulation; coat; cold; collaboration; collected; collections; column; combination; combined; commercial; common; comparison; compatible; compatible blood; complement; complete; complex; compliance; complications; concentrates; concentration; concerned; concerns; conclusion; conditions; confirmed; consequence; considerable; consideration; considered; consumption; contamination; content; continuous; contrast; control; control group; conventional; coombs; cord blood; core; corrective; correlation; cost; council; count; counting; countries; country; course; criteria; critical; croatia; cross; crossmatch; csf; culture; current; cytokines; cytometry; d type; d+ blood; daily; data; date; day; days; december; decision; decrease; deferrals; deferred; degree; delayed; delivery; department; depletion; design; detailed; detectable; detection; determination; determined; development; device; diagnosis; diamed; differences; different; different anti; different blood; difficult; direct; directive; disaster; discussion; disease; disorders; distribution; dna; doctors; donations; donor cells; dose; double; drugs; duration; e.g.; early; easy; ebds; education; effect; effective; effective blood; effectiveness; efficacy; efficient; efforts; eia; elasticity; elements; elimination; elisa; end; environment; enzyme; equal; equipment; errors; erythrocytes; essential; established; estimated; etc; european; european blood; evaluation; events; evidence; excessive; exchange; exclusion; exons; expected; experience; exposure; expression; external; extraction; factor; failure; false; family; febrile; female; female blood; female donors; ferritin; fetal; fetus; ffp; fibrinogen; filter; filtration; final; findings; flow; fluorescence; focus; following; fractionation; france; free; freezing; frequency; frequent; fresh; fresh blood; frozen; function; future; g'max; gamma; gel; general; generation; genes; genetic; genotype; genotyping; gestation; glucose; goal; good; graft; granulocyte; greater; greece; group system; groups; growth; guidelines; gvhd; h63d; haematological; haemolysis; haemovigilance; half; hbc; hbsag; hbv; hcv; hcv antibodies; hdn; health; help; hematocrit; hematology; hematopoietic; hemocue; hemoglobin; hemolytic; hemolytic transfusion; hemorrhage; heparin; hepatitis; heterozygous; high; high blood; higher; history; hiv; hla; homologous blood; homozygous; hospital; hospital blood; hospital transfusion; host; hours; hpa; hpa-1a; hsr; htlv; human; human blood; i.v; identification; igg; igm; il-10; ill; immediate; immune; immunization; immunoassay; immunoglobulin; impact; implementation; important; improved; improvement; incidence; incompatibility; incorrect blood; increased; increasing; incubated; incubation; independent; independent blood; index; indications; indirect; individuals; infants; infected; infections; inflammatory; influence; information; informed; infusion; inhabitants; initial; injury; institute; institutions; insufficient; integrated; intensive; intercept blood; internal; international; intervention; intravenous; introduction; intron; investigation; involved; iron; irradiated; irradiation; irregular; isolated; issue; ivig; january; jka; kell; kidd; kit; knowledge; known; labile blood; laboratories; laboratory; lack; lactate; large; law; lead; leucodepleted; leucodepletion; leukocyte; level; life; light; like; likely; limited; liss; literature; load; local; local blood; long; lots; low; lower; lst1; magnetic; main; maintenance; major; major blood; majority; males; malignant; management; mandatory; manual; manufacturing; markers; marrow; massive; material; maximum; mbl; mcmv; mds; mean; measured; measurements; mechanisms; median; medical; medium; membrane; metabolic; methods; microplate; mild; ministry; minutes; mmol; mnc; model; modified; mods; molecular; molecules; monitoring; monoclonal; monoclonal anti; months; morbidity; mortality; mother; multiple; multiple blood; mutation; n =; national blood; necessary; need; negative; negative blood; neonatal; new; new blood; new donors; newborn; non; normal; nucleic; number; objective; observation; observed; occurrence; old; ones; operations; optimal; order; organization; ortho; outcome; overall; oxygen; p =; pabd; packed; pall; panels; parameters; partial; participants; particular; past; pathogen; pathway; patients; patients anti; patients blood; pcr; pcs; people; percentage; performance; period; peripheral blood; personal; personnel; phase; phenotype; physical; physicians; place; plasma; plasma samples; plasma transfusion; plasma units; plasmapheresis; platelet; platelet concentrates; platelet count; platelet products; platelet quality; platelet storage; platelet transfusion; plt; point; policy; polish blood; polyclonal; pooled; pools; poor; population; positive; positive antibody; positive blood; positive cells; positive control; positive donors; positive patients; positive results; positive samples; positivity; possibility; possible; post; post transfusion; postoperative; potential; practice; practitioners; predonation; pregnancies; pregnancy; pregnant; preliminary; premature; preoperative; preparation; prepared; presence; present; prevalence; prevention; previous; primary; principles; prior; prism; problem; procedure; process; processes; processing; procleix; professional; program; programme; project; proper; prophylactic; proportion; prospective; protection; protein; protocol; pth; public; pulmonary; purpose; quality; quality blood; quality control; quality system; quantitative; questionnaire; questions; rabbits; random; randomized; range; rapid; rare; rare blood; rbc; rbc transfusion; rbcs; rccs; rcts; reactive; reagents; real; reasons; recent; recipients; recombinant; recommendations; recovery; red blood; red cell; reduced; reduction; reference; regional blood; regions; regular; regular blood; regulations; regulatory; related; relative; release; relevant; reliable; removal; repeat blood; replacement; reported; reporting; reports; republic; required; requirements; research; residual; resources; respect; respiratory; response; responsible; restrictive; results; retrospective; reverse; review; rhd; rhesus; risk; rna; roche; role; room; routine; routine blood; run; sampling; scansystem; scientific; screened; screening; second; security; selection; self; sensitive; sensitivity; separator; sepsis; sequence; sera; serbia; seroconversion; serological; serology; serum; services; set; setting; severe; severity; sex; shock; short; shows; sickle; significant; signs; similar; simple; singapore; single; site; situations; size; small; society; software; solution; source; special; specific; specific antibodies; specific blood; specificity; specimens; srbc; ssp; staff; standard; state; statistical; status; step; storage; strategies; strategy; students; studies; study; study blood; subjects; subsequent; subsequent blood; successful; suffering; suggested; summary; support; surface; surgery; surgery patients; surgical; survey; survival; symptoms; syndrome; syphilis; system; system antibodies; table; target; technical; technique; technologies; technology; temperature; temporary; test; test results; tested; testing; thalassemia; therapeutic; therapy; thrombin; thrombocytopenia; throughput; time blood; time donors; times; titer; titre; tool; total; training; trali; transfusion center; transfusion hepatitis; transfusion medicine; transfusion policy; transfusion practice; transfusion reactions; transfusion safety; transfusion service; transfusion system; transfusion testing; transfusion therapy; transfusions; transmission; transplantation; transport; trauma; trauma patients; treated; treatment; trend; trials; trigger; trima; tube; tumor; turkey; type; typing; ultrio; understanding; underwent; unique; university; unpaid blood; unrelated; usage; use; useful; validation; value; variable; vascular; venous blood; viability; viii; viral; virus; viruses; vitro; vivo; voluntary blood; volunteers; washed; way; wbc; weak; weak d; weeks; weight; white blood; wide; window; women; work; working; world; years; yield; young; ° c cache: cord-023364-ut56gczm.txt plain text: cord-023364-ut56gczm.txt item: #29 of 79 id: cord-025634-31n5fvex author: Zhuge, Shurui title: The prevalence of occult HBV infection in immunized children with HBsAg-positive parents: a hospital-based analysis date: 2020-05-29 words: 3987 flesch: 46 summary: Considering the significant reservoir of HBV infections, the status of HBV infection in many countries is still not optimistic. For HBV DNA detectable children, 20 (13.6%, 95% CI 8.0-19.2%), 24 (14.0%, 95% CI 8.7-19.2%) were found with HBV father-carriers, mother-carriers. keywords: analysis; anti; antigen; areas; blood; carriers; children; china; clinical; detectable; dna; factors; father; fig; gene; hbc; hbig; hbsag; hbv; hepatitis; immunized; infection; mothers; negative; nested; obi; occult; parents; pcr; positive; prevalence; rate; regions; results; risk; samples; sequences; sequencing; serum; significant; statistical; study; test; transmission; vaccinated; values; variables; version; virus; years cache: cord-025634-31n5fvex.txt plain text: cord-025634-31n5fvex.txt item: #30 of 79 id: cord-026112-58sa5z03 author: Dehghani-Dehej, Farzaneh title: Prevalence of HCV and/or HBV coinfection in Iranian HIV-infected patients date: 2020-04-24 words: 4005 flesch: 41 summary: HIV diagnosis and treatment through advanced technologies World Health Organization Global Health Observatory Current diagnostic methods for HIV Interference of apoptosis by hepatitis B virus Characterization of hepatitis B virus with complex structural variations HIV-hepatitis B virus coinfection: epidemiology, pathogenesis, and treatment Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity Hepatitis B: screening, awareness, and the need to treat Hepatitis B virus infection in the general population of Iran: an updated systematic review and meta-analysis Hepatitis C virus (HCV) genotyping by annealing reverse transcription-PCR products with genotype-specific capture probes Identification of a novel hepatitis C virus genotype from Punjab, India: expanding classification of hepatitis C virus into 8 genotypes Molecular epidemiology of hepatitis C virus in Cambodia during 2016-2017 Hepatitis B, hepatitis C, and mortality among HIV-positive individuals Seroprevalence of hepatitis C virus: the first population-based study from Iran The impact of IFN-γ gene polymorphisms on spontaneous clearance of HCV infection in Fars Province, Southern of Iran The presence of autoantibodies to cytoplasmic rod and ring particles in the serum of patients with chronic hepatitis C virus infection Hepatocellular carcinoma after sustained virological response with interferon-free regimens in HIV/hepatitis C virus-coinfected patients HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS) Hepatitis B and long-term HIV outcomes in co-infected HAART recipients Survival in patients with HIV infection and viral hepatitis B or C: a cohort study Management of HIV and hepatitis virus coinfection Human immunodeficiency virus/hepatitis C Virus (HCV) co-infected patients with cirrhosis are no longer at higher risk for hepatocellular carcinoma or end-stage liver disease as compared to HCV mono-infected patients Liver fibrosis and hepatitis B coinfection among ART naive HIV-infected patients at a tertiary level hospital in Northwestern Tanzania: a cross-sectional study Detection of hepatitis B virus covalently closed circular DNA in the plasma of Iranian HBeAg-negative patients with chronic hepatitis B Detection of HBV genome in the plasma and peripheral blood mononuclear cells of Iranian HBsAg negative patients with HIV infection: occult HBV infection Distribution of hepatitis B virus genotypes in azerbaijani patients with chronic hepatitis B infection Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors Hepatitis C genotypes in Finland determined by RFLP Occult hepatitis C virus infection in Iranian patients with cryptogenic liver disease Trends in underlying causes of death in people with HIV from Co-infection of human immunodeficiency virus, hepatitis C and hepatitis B virus among injection drug users in Drop in centers Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis Trend of HIV/AIDS prevalence and related interventions administered in Prisons of Iran − 13years' experience Antiretroviral drug resistance mutations in naïve Islamic Republic of Iran AIDS Progress Report HIV-1 genetic diversity and transmitted drug resistance frequency among Iranian treatment-naive, sexually infected individuals Epidemiological distribution and genotype characterization of the hepatitis C virus among HIV patients in Kashan High prevalence of HCV coinfection in HIV-infected individuals in Shiraz, Islamic Republic of Iran Sexually transmitted hepatitis C infection: the new epidemic in MSM? Occasional spontaneous clearance of chronic hepatitis C virus in HIV-infected individuals HIV and HCV coinfection: prevalence, associated factors and genotype characterization in the midwest region of Brazil Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in south India and characterization of HCV genotypes Detection and analysis of hepatitis C virus in HIV-infected patients in the Guangxi province of China Long-term liver diseases after initiation of antiretroviral therapy in HIV-infected patients with and without HBV or HCV coinfection Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level HIV-Hepatitis B virus co-infection: epidemiology, pathogenesis and treatment Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1− infected individuals Hepatitis C, hepatitis B, and human immunodeficiency virus infections among non-intravenous drug-using patients attending clinics for sexually transmitted diseases Epidemiology of hepatocellular carcinoma: New trends Prevalence and trend of hepatitis C virus infection among blood donors in Iran: a systematic review and meta-analysis Incidence and residual risk of HIV, HBV and HCV infections among blood donors in Tehran Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study Factors associated with hepatitis B and C co-infection among HIV-infected patients in Singapore Daclatasvir plus sofosbuvir, with or without ribavirin, in real-world patients with HIV-HCV coinfection and advanced liver disease Comparison of demographic, epidemiological, immunological, and clinical characteristics of patients with HIV mono-infection versus patients co-infected with HCV or/and HBV: a Serbian cohort study HBV and HCV coinfection prevalence in Iran-a systematic review and meta-analysis Hepatic decompensation in patients with HIV/hepatitis B Virus (HBV)/hepatitis C Virus (HCV) triple infection versus HIV/HCV coinfection and the effect of anti-HBV nucleos(t)ide therapy HIV infection exacerbates natural history of HCV infection. keywords: analysis; anti; antigen; blood; cirrhosis; dna; donors; drug; epidemiology; genotype; genotyping; hbcab; hbsag; hbv; hcc; hcv; hepatitis; higher; history; hiv; individuals; infected; infection; iran; iranian; kit; liver; load; mortality; negative; participants; patients; pcr; people; plasma; population; positive; prevalence; research; risk; rna; samples; sexual; specimens; studied; study; subjects; table; transmission; viral; virus; world cache: cord-026112-58sa5z03.txt plain text: cord-026112-58sa5z03.txt item: #31 of 79 id: cord-027860-s97hdhh6 author: Zeimet, Anthony title: Infectious Diseases date: 2020-06-22 words: 28951 flesch: 42 summary: Management of such patients should be coordinated with an infectious diseases specialist, who also should manage drug-resistant TB treatment. Single positive blood culture for Coxiella burnetii or anti-phase 1 IgG antibody titer >1:800 Echocardiogram positive for IE (TEE recommended for patients with prosthetic valves, rated at least possible IE by clinical criteria, or complicated IE [paravalvular abscess]; TTE as first test in other patients) defined as follows: oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation; or abscess; or new partial dehiscence of prosthetic valve; new valvular regurgitation (worsening or changing or preexisting murmur not sufficient) Predisposition, predisposing heart condition, or IDU Fever, temperature >38° C Vascular phenomena, major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway's lesions Immunologic phenomena: glomerulonephritis, Osler's nodes, Roth's spots, and rheumatoid factor Microbiologic evidence: positive blood culture but does not meet a major criterion as noted above * or serological evidence of active infection with organism consistent with IE Echocardiographic minor criteria eliminated Echocardiography should be performed in all patients with suspected infective endocarditis (Baddour et al., 2005) keywords: abdominal; abscess; acid; active; acute; acyclovir; addition; administration; adults; agents; amoxicillin; analysis; animal; antibiotic therapy; antibiotics; antibody; antimicrobial; appearance; appropriate; area; arthritis; ascitic; associated; asymptomatic; aureus; available; azithromycin; bacilli; bacterial; bacteriuria; benefit; biopsy; bite; blood; bone; bronchitis; cardiac; care; cases; catheter; causative; cause; cells; cellulitis; cephalexin; cephalosporin; cervical; changes; chest; children; chills; chlamydia; choice; chronic; clindamycin; clinical; coli; common; community; control; cough; count; course; coverage; criteria; csf; culture; daily; days; debridement; decrease; development; diabetic; diagnosis; diarrhea; differential; difficile; discharge; disease; dose; doxycycline; drainage; drug; duration; dysuria; early; edema; effective; elderly; elevated; empiric; encephalitis; endemic; endocarditis; etiologic; evaluation; evidence; examination; exposure; factors; fever; figure; findings; flora; fluid; fluoroquinolone; foot; form; fuo; generation; genital; gram; greater; guidelines; hav; hbv; hcv; headache; health; heart; helpful; hepatitis; herpes; high; higher; history; hiv; hospital; host; hours; hpv; hsv; human; illness; immune; immunocompromised; important; incidence; individuals; infected; infection; infective; inflammation; influenza; initial; injury; intravenous; isoniazid; joint; laboratory; latent; lesions; levels; likely; limited; liver; longer; low; lyme; major; making; malaise; management; material; measles; medical; meningitis; mononucleosis; months; mortality; mri; mrsa; nausea; necessary; need; negative; normal; number; onset; oral; organism; origin; osteomyelitis; pain; partners; pathogens; patients; pcr; pelvic; penicillin; peritonitis; persons; phase; physical; physician; pneumonia; population; positive; possible; potential; ppd; practice; preferred; pregnancy; pregnant; presence; present; presentation; prevention; primary; procedures; prophylaxis; pulmonary; pyelonephritis; q12h; radiograph; range; rash; rate; recent; recommendations; recurrent; regimen; repeat; resistant; respiratory; response; results; rifampin; risk; rmsf; routine; rule; sbp; screening; secondary; serum; setting; severe; sexual; significant; signs; simplex; single; skin; smx; society; soft; sor; species; specific; spp; spread; sputum; stain; standard; staphylococcus; states; stis; streptococci; studies; supportive; surgical; symptoms; syphilis; systemic; table; testing; tests; therapy; tick; times; tissue; tmp; tract; transmission; travelers; treatment; tuberculosis; type; ulcer; uncomplicated; underlying; united; untreated; upper; urinary; urine; use; uti; utis; vaccination; vaccine; vaginal; vancomycin; varicella; viral; virus; viruses; vomiting; warts; wbc; weeks; women; wounds; years; zoster cache: cord-027860-s97hdhh6.txt plain text: cord-027860-s97hdhh6.txt item: #32 of 79 id: cord-030369-4dn02a35 author: Peng, Liang title: Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure) date: 2019-05-21 words: 35873 flesch: 36 summary: Of the possible complications occurring in liver failure patients, bleeding is the most common and severe. Concomitant infection in liver failure patients has the following characteristics: (1) a high incidence; (2) infection may occur at different sites either simultaneously or sequentially, and abdominal and biliary tract infection is the most common. keywords: abdominal; abnormal; acid; aclf; activation; active; activity; acute exacerbation; acute hepatitis; acute liver; acute severe; addition; adefovir; aechb; affected; alf; alf patients; alt; amino; ammonia; analysis; antigen; antiviral; apoptosis; area; arterial; artificial liver; ascites; associated; b virus; bacterial; ballooning; basis; bile; bilirubin; binding; biological; bleeding; blood; brain; bridging; carriers; cases; cause; cellular; central; cerebral; changes; characteristics; chb; chb patients; china; chinese; cholestasis; chronic hbv; chronic hepatitis; chronic liver; chronic severe; cirrhosis; cirrhosis patients; classification; clearance; clinical; coagulation; common; complications; concentration; concomitant; condition; confluent; control; core; course; cytokines; days; death; decompensated; decompensation; degeneration; degree; detection; deterioration; development; diagnosis; different; difficult; diffuse; disease patients; diseases; dna; drug; dysfunction; early; edema; effect; effective; efficacy; encephalopathy; end; endotoxemia; entecavir; evaluation; evidence; exacerbation; examination; example; expression; extensive; factors; failure patients; features; fibrosis; following; forms; fulminant; fulminant hepatitis; fulminant liver; gastrointestinal; gcs; gene; genetic; genome; genotype; grade; guidelines; hbeag; hbv; hbv infection; hbv replication; hemorrhage; hepatic; hepatic cirrhosis; hepatic encephalopathy; hepatic failure; hepatitis; hepatitis patients; hepatocellular; hepatocytes; hepatorenal; high; higher; history; hormone; host; hps; hrs; human; hypertension; ifn; il-10; immune; immunity; important; incidence; increased; increasing; independent; infected; infection; infiltration; inflammation; inflammatory; influence; inhibit; inr; intracranial; intrahepatic; jaundice; key; laboratory; lactic; lamivudine; large; levels; life; like; liver biopsy; liver cells; liver cirrhosis; liver damage; liver disease; liver failure; liver function; liver injury; liver necrosis; liver tissue; liver transplantation; lobules; long; low; lps; lymphocytes; main; major; manifestations; massive; mechanism; meld; metabolic; methods; model; molecule; months; mortality; mouse; multiple; mutants; mutation; necessary; necrosis; negative; neutrophils; new; non; normal; number; obvious; occurrence; onset; organ; pathogenesis; pathological; pathway; patients; pct; peripheral; persistent; plasma; platelets; point; poor; portal; positive; practice; predictive; presence; present; pressure; prevention; primary; process; production; prognosis; progression; promoter; protein; prothrombin; pta; pulmonary; quasispecies; rapid; rare; rate; reaction; recent; receptor; recovery; reduced; region; regulate; regulation; related; renal; replication; reported; resistance; response; result; risk; role; salf; scholars; scoring; secondary; selection; sequence; sequencing; serum; severe hepatitis; severe liver; severe type; severity; short; signal; significant; similar; single; site; slf; small; specific; spontaneous; stage; stage liver; status; studies; study; subacute; surface; survival; symptoms; syndrome; synthesis; system; tendency; tenofovir; term; tests; th17; therapeutic; therapy; time; tlr4; tnf; total; transcription; treatment; tremor; type; type hepatitis; type patients; value; viral; viral hepatitis; virus; virus infection; weeks; years cache: cord-030369-4dn02a35.txt plain text: cord-030369-4dn02a35.txt item: #33 of 79 id: cord-032183-yqqqe325 author: Ning, Qin title: Antiviral Therapy for AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 words: 32709 flesch: 39 summary: Survival analysis of 190 patients with HBV-related acuteon-chronic liver failure Does antiviral therapy reduce complications of cirrhosis? Hepatitis B-associated fibrosis and fibrosis/cirrhosis regression with nucleoside and nucleotide analogs Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepatitis B infection Lamivudine for patients with chronic hepatitis B and advanced liver disease Determinants of early mortality in patients with decompensated chronic hepatitis B treated with antiviral therapy The role of lamivudine and predictors of mortality in severe flare-up of chronic hepatitis B with jaundice Meta-analysis of the short-term effects of lamivudine treatment for severe chronic hepatitis B Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B Adefovir dipivoxil therapy for lamivudine resistant hepatitis B in pre-and post-liver transplantation patients Long-term therapy with adefovir dipivoxil for HBeAg negative chronic hepatitis B for up to 5 years A comparison of entecavir and lamivudine for HBeAgpositive chronic hepatitis B Entecavir versus lamivudine for patients with HBeAgnegative chronic hepatitis B Entecavir versus lamivudine therapy for patients with chronic hepatitis B-associated liver failure: a meta-analysis Entecavir vs. lamivudine in chronic hepatitis B patients with severe acute exacerbation and hepatic decompensation The pros and cons of lamivudine vs. entecavir in decompensated or severe acute exacerbation of chronic hepatitis B Efficacy and safety of telbivudine therapy in liver failure patients with chronic hepatitis B virus infection Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment-naïve patients with HBV-related decompensated cirrhosis Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure The study of efficacy of lamivudine in patients with severe acute hepatitis B HBV-DNA suppression and disease course in HBV cirrhosis patients on long-term lamivudine therapy Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine Long-term continuous entecavir therapy in nucleos(t) ide-naïve chronic hepatitis B patients Update in the management of chronic hepatitis B Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level United States Lamivudine Compassionate Use Study Group. In 64% of patients HBV DNA levels were detectable by the branched chain DNA assay. keywords: aasld; ablation; aclf; active; activity; acute; addition; adefovir; adv; adverse; aechb; agents; alt; analogs; analogues; analysis; antigen; antiviral; antiviral therapy; antiviral treatment; apoptosis; association; b immune; b virus; baseline; benefit; breakthrough; cancer; carcinoma; cases; cccdna; cells; chb; chb patients; chemotherapy; china; chinese; chronic hbv; chronic hepatitis; chronic liver; cirrhosis; cirrhosis patients; cirrhotic; clinical; combination; combination therapy; combined; complete; comprehensive; consensus; continuous; control; copies; course; ctp; cumulative; curative; cure; current; cytotoxic; damage; data; death; decompensated; decompensation; decrease; development; different; dipivoxil; disease; dna level; dose; drug; early; easl; effect; effective; efficacy; emtricitabine; entecavir; entry; etv; evidence; exacerbation; expression; factors; failure; failure patients; fibrosis; follow; function; globulin; goal; group; growth; guidelines; hbeag; hbig; hbs; hbv; hbv dna; hbv infection; hbv reactivation; hbv recurrence; hbv replication; hbv therapy; hbv treatment; hbx; hcc; hcc patients; hepatic; hepatitis b; hepatocellular; hepatocyte; high; high hbv; higher; hiv; host; human; ifn; immune; immunosuppressive; important; improved; improvement; incidence; increased; independent; infected; infection; inflammation; inhibit; initial; interferon; lamivudine; lamivudine treatment; ldt; lead; level; life; liver; liver cancer; liver cirrhosis; liver disease; liver failure; liver function; liver transplantation; load; long; loss; low; lower; management; median; medical; meld; meta; monotherapy; months; mortality; mutations; nas; need; negative; negative patients; new; non; normal; nucleoside; number; oral; outcome; overall; pathway; patients; peg; pegylated; period; poor; positive; positive patients; post; postoperative; potent; practice; predictor; pregnancy; prevention; prognosis; progression; prophylaxis; prospective; protein; randomized; rate; reactivation; recent; recommendations; recurrence; replication; rescue; resection; resistance; response; results; risk; role; safety; score; sequential; seroconversion; serum; serum hbv; severe; severe hepatitis; significant; similar; specific; stage; strategies; studies; study; suppression; surface; survival; sustained; switch; tace; tdf; telbivudine; tenofovir; term; therapeutic; therapy; thyroid; time; tolerance; total; transplantation; treatment; treatment group; trial; tumor; use; vaccination; vaccine; virological; virus; virus infection; weeks; years cache: cord-032183-yqqqe325.txt plain text: cord-032183-yqqqe325.txt item: #34 of 79 id: cord-252586-fuaoelgb author: Phillips, Sandra title: Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production date: 2014-10-08 words: 5540 flesch: 38 summary: The level of intracellular HBV DNA also was reduced by approximately 60% after 72 hours of treatment with 5 and 20 mg/mL of alisporivir (P < .01). Importantly, the Southern blot analysis of intracellular DNA supports the quantitative real-time PCR results outlined earlier because alisporivir reduced intracellular HBV DNA in a dose-dependent manner ( Figure 1E ). keywords: activity; alisporivir; alv; antigen; antiviral; cells; combination; concentrations; culture; cycle; cyclophilin; cypa; cypb; cypc; cypd; dependent; dna; effect; experiments; expression; figure; hbsag; hbv; hbv dna; hbv replication; hcv; heparg; hepatitis; hepatocytes; hepg2215; hepg2215 cells; host; hours; human; infected; infection; inhibition; inhibitors; intracellular; levels; life; medium; mmol; nim811; nucleocapsid; pcr; polymerase; present; protein; real; reduction; replication; secretion; silencing; sirna; study; supernatants; supplementary; telbivudine; time; transfection; treatment; virus cache: cord-252586-fuaoelgb.txt plain text: cord-252586-fuaoelgb.txt item: #35 of 79 id: cord-255697-trig04hd author: Cheng, Vincent Chi-Chung title: Viral Infections, an Overview with a Focus on Prevention of Transmission date: 2016-10-24 words: 6425 flesch: 32 summary: norovirus shedding time associated with age Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Prevention of nosocomial respiratory syncytial virus infections through compliance with glove and gown isolation precautions Immunization with high-dose intradermal recombinant hepatitis B vaccine in healthcare workers who failed to respond to intramuscular vaccination Epidemiologic study and containment of a nosocomial outbreak of severe acute respiratory Prospective controlled study of four infection-control procedures to prevent nosocomial infection with respiratory syncytial virus Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic An effective quarantine measure reduced the total incidence of influenza A H1N1 in the workplace: another way to control the H1N1 flu pandemic An outbreak of influenza aboard a commercial airliner Efficacy and effectiveness of influenza vaccination Rapid awareness and transmission of severe acute respiratory syndrome in Hanoi French Hospital, Vietnam. As the virus may survive on inanimate surfaces for 12-48 h, and on the surface of hands for 10-15 min (Kampf and Kramer, 2004; Kramer et al., 2006) , influenza virus can be transmitted indirectly by contact with hands from the contaminated environment to the pharyngeal mucosa. keywords: acid; acute; agents; airborne; antibody; antiviral; areas; available; blood; care; care workers; cases; cheng; children; clinical; community; contact; control; coronavirus; countries; days; diagnosis; disease; early; ebola; effective; epidemic; epidemiological; et al; evd; exposure; gloves; h1n1; hand; hbv; hcv; health; healthcare; hepatitis; high; hiv; home; hong; hospital; human; hygiene; important; incidence; index; infected; infection; infection control; influenza; isolation; kong; management; measles; measures; mortality; new; norovirus; nosocomial; nucleic; nursing; outbreak; pandemic; patients; pep; period; positive; ppe; precautions; prevention; public; quarantine; rapid; rate; respiratory; risk; rsv; sars; school; secondary; severe; source; spread; study; syncytial; syndrome; tests; time; total; transmission; treatment; vaccination; vaccine; viral; virus; viruses; water; workers cache: cord-255697-trig04hd.txt plain text: cord-255697-trig04hd.txt item: #36 of 79 id: cord-258665-8q3tsggm author: Aydın, Hakan Berk title: Pixelated colorimetric nucleic acid assay date: 2020-03-01 words: 4065 flesch: 39 summary: nanotechnologies Recent advances in micro/nanotechnologies for global control of hepatitis B infection Point-of-care nucleic acid testing for infectious diseases Diagnostics for developing countries Nucleic acid testing-benefits and constraints 3D capillary-driven paper-based sequential microfluidic device for electrochemical sensing applications Diagnostics for the developing world: microfluidic paper-based analytical devices Equipment-free detection of K+ on microfluidic paper-based analytical devices based on exhaustive replacement with ionic dye in ion-selective capillary sensors A fully disposable and integrated paper-based device for nucleic acid extraction, amplification and detection Single-step recombinase polymerase amplification assay based on a paper chip for simultaneous detection of multiple foodborne pathogens Ultrasensitive paper based nucleic acid detection realized by three-dimensional DNA-AuNPs network amplification Conjugated polyelectrolytes: synthesis, photophysics, and applications Optical detection of DNA and proteins with cationic polythiophenes Recent advances in fluorescent and colorimetric conjugated polymer-based biosensors Twisting of conjugated oligomers and polymers: case study of oligo-and polythiophene Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes Naked eye detection of lung cancer associated miRNA by paper based biosensing platform Tailoring conformation-induced chromism of polythiophene copolymers for nucleic acid assay at resource limited settings Multiplex paper-based colorimetric DNA sensor using pyrrolidinyl peptide nucleic acid-induced AgNPs aggregation for detecting MERS-CoV, MTB, and HPV oligonucleotides Flow-through colorimetric assay for detection of nucleic acids in plasma Luminescent device for the detection of oxidative stress biomarkers in artificial urine Smart phone assisted detection and quantification of cyanide in drinking water by paper based sensing platform Smartphone instrument for portable enzymelinked immunosorbent assays Smartphone spectrometer for colorimetric biosensing Smartphone-based food diagnostic technologies: a review Detection of hepatitis B virus DNA with a paper electrochemical sensor Flow-through colorimetric assay for detection of nucleic acids in plasma Clinical evaluation of micro-scale chip-based PCR system for rapid detection of hepatitis B virus Ultrasensitive paper based nucleic acid detection realized by three-dimensional DNA-AuNPs network amplification Hepatitis B plasmonic biosensor for the analysis of clinical serum samples Colorimetric detection of hepatitis B virus (HBV) DNA based on DNA-templated copper nanoclusters Gold aggregating gold: a novel nanoparticle biosensor approach for the direct quantification of hepatitis C virus RNA in clinical samples This work has been supported by the The Scientific and Technological Research Council of Turkey TUBİTAK Project no:116Z547. The obtained results illustrate that a ubiquitous smartphone can be utilized for colorimetric nucleic acids assays in complex matrices via the developed application that perform point of care without requiring sophisticated software nor instrumentation. keywords: acid; algorithm; analysis; application; approach; assay; biorgb; care; cartridge; colorimetric; colorimetric responses; concentration; control; cpe; detection; diagnosis; digital; dna; droplet; eye; fig; hbv; hbv dna; hepatitis; image; individual; intensity; interest; interpretation; membrane; naked; nucleic; optical; paper; pattern; phone; pixelated; pixels; plasma; pna; point; processing; pvdf; quantification; rapid; red; responses; sample; sequence; smart; smartphone; software; spots; step; target; times; values; yield cache: cord-258665-8q3tsggm.txt plain text: cord-258665-8q3tsggm.txt item: #37 of 79 id: cord-264488-989t9ld1 author: Park, Il-Hyun title: Inhibition of hepatitis B virus replication by ligand-mediated activation of RNase L date: 2014-02-06 words: 5333 flesch: 46 summary: Because p2-5A is a unique and specific activator for RNase L, these results strongly indicated that the observed inhibition of HBV was the result of RNase L activation. RNase L activation requires 2-5A, which is synthesized by OAS. keywords: activation; activity; antiviral; cells; cellular; chronic; data; days; dmem; dna; dsrna; effect; et al; expression; family; fig; gene; genome; hbv; hepatitis; hepatoma; hepg2; human; ifn; induction; infected; infection; inhibition; interferon; likely; ntcp; oas; oas1; oas2; oas3; observed; pgrna; pmm; poly(i; protein; replication; results; ribonuclease; rnase; rnase l; role; specific; study; transcripts; transfection; treatment; type; viral; virus; viruses cache: cord-264488-989t9ld1.txt plain text: cord-264488-989t9ld1.txt item: #38 of 79 id: cord-264713-38dlh3wg author: Vernet, Guy title: Molecular diagnostics in virology date: 2004-08-20 words: 4802 flesch: 36 summary: in 2001 illustrate the interest of multiplex detection of respiratory viruses by NAT. Table 6 Multiplex Nat for the detection of respiratory viruses (Hexaplex, Prodesse Inc.) DNA-microarrays or DNA-Chips are very powerful detection tools that can be combined with amplification techniques to detect viruses or virus variants (reviewed in Clewley, 2004) . keywords: acid; acute; amplification; antiviral; assays; automation; available; blood; case; clinical; commercial; companies; detection; development; diagnosis; different; discovery; disease; dna; donations; efficiency; et al; example; family; fig; hbv; hcv; hepatitis; herpesviridae; high; hiv; hpv; human; identification; important; infections; ivd; laboratories; load; major; microarray; molecular; multiplex; mutations; nat; need; new; nucleic; pathogens; patients; pcr; platforms; primers; probes; rapid; real; recent; resistance; respiratory; samples; sensitivity; sequences; single; specimen; table; techniques; testing; tests; time; units; usa; viral; virology; viruses cache: cord-264713-38dlh3wg.txt plain text: cord-264713-38dlh3wg.txt item: #39 of 79 id: cord-265472-b1s4stvz author: Guimarães, Luísa Eça title: Vaccines, adjuvants and autoimmunity date: 2015-10-31 words: 14650 flesch: 37 summary: An experimental study in Brown Norway rats Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity Six revolutions in vaccinology From Pasteur to genomics: progress and challenges in infectious diseases Systems vaccinology Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century Studies of twins in vaccinology Vaccinomics current findings, challenges and novel approaches for vaccine development The HLA genomic loci map: expression, interaction, diversity and disease The link between genetic variation and variability in vaccine responses: systematic review and meta-analyses Development of polyarthritis after insertion of silicone breast implants followed by remission after implant removal in 2HLA-identical sisters bearing rheumatoid arthritis susceptibility genes Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine Anticardiolipin and anti-beta(2) glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits Autoimmunity and hepatitis A vaccine in children Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome Vaccination-induced systemic autoimmunity in farmed Atlantic salmon Autoimmune response following annual influenza vaccination in 92 apparently healthy adults High non-specific T lymphocyte response to the adjuvanted H1N1 vaccine in comparison with the H1N1/H3N2/B-Brisbane vaccine without adjuvant Short and long-term effects of pandemic unadjuvanted influenza A(H1N1) pdm09 vaccine on clinical manifestations and autoantibody profile in primary Sjögren's syndrome Pneumococcal vaccination of patients with systemic lupus erythematosus: effects on generation of autoantibodies Immunogenicity and safety of a quadrivalent human papillomavirus vaccine in patients with systemic lupus erythematosus: a case-control study Safety and immunogenicity of the quadrivalent HPV vaccine in female systemic lupus erythematosus patients aged 12 to 26 years Anti-phospholipid antibodies following vaccination with recombinant hepatitis B vaccine Development of autoantibodies before the clinical onset of systemic lupus erythematosus Genetics and autoantibodies Silicone and autoimmunity Platinum in the environment: frequency of reactions to platinum-group elements in patients with dermatitis and urticaria Silicone and scleroderma revisited Rupture of silicone gel breast implants and symptoms of pain and fatigue This suggests that genomics is crucial in inter-individual variations in vaccine immune responses [82] . keywords: activation; acute; adaptive; adem; adjuvants; administration; adverse; age; aluminum; anti; antibodies; antigen; antiphospholipid; aps; arthritis; asia; associated; association; autoantibodies; autoimmune; autoimmune disease; autoimmunity; bcg; bladder; body; brain; breast; bullous; calmette; cancer; cases; cause; celiac; cell; central; cervical; cfs; childhood; children; chronic; class; clinical; cns; components; conditions; conjugate; connective; cytokines; data; described; developing; development; diabetes; diagnosis; different; disease; effect; effective; efficacy; encephalomyelitis; enhanced; environmental; erythematosus; etiology; events; evidence; experimental; exposure; factors; fatigue; fever; fibromyalgia; fms; frequent; general; genetic; gulf; h1n1; hbv; healthy; hepatitis; higher; hla; host; hpv; human; hypersensitivity; iim; immune response; immunization; implants; incidence; individuals; induction; infection; inflammatory; influenza; influenza vaccination; innate; itp; like; link; literature; long; loss; low; lupus; major; manifestations; mechanisms; meningococcal; mice; mimicry; mmf; mmr; models; molecular; molecules; multiple; muscle; narcolepsy; natural; nervous; neurological; non; novel; observed; oil; onset; pain; papillomavirus; pathogenesis; pathogens; patients; pemphigoid; pneumococcal; polysaccharide; possible; post; presence; present; prevalence; previous; production; protein; prrs; purpura; reactions; relationship; reports; research; response; results; review; rheumatoid; risk; role; rotavirus; rubella; safety; sclerosis; self; silicone; sle; small; specific; studies; study; symptoms; syndrome; systemic; t1d; term; tetanus; thrombocytopenia; tissue; tlrs; toxoid; treatment; trigger; tuftsin; type; vaccinated; vaccination; vaccine; vasculitis; viral; virus; women; years cache: cord-265472-b1s4stvz.txt plain text: cord-265472-b1s4stvz.txt item: #40 of 79 id: cord-266105-8avkjc84 author: None title: cord-266105-8avkjc84 date: None words: 13081 flesch: 42 summary: Several strategies may help reduce the threat of AIV to equines, including reducing exposure of equines to poultry, birds, and other hosts of IAV, especially animals with clinical signs of influenza virus infection; monitoring AIV prevalence in domestic poultry around equines and routinely vaccinating domestic poultry with AIV vaccines; vaccinating susceptible equines with EI vaccines, especially farming equines in close contact with domestic poultry; and monitoring the prevalence of multiple AIV subtypes in equines, not merely that of those restricted to H3N8 subtype. 5 Low humidity and temperature increased the stability of influenza virus in aerosols and on surfaces. keywords: 16s; 6xi; a(h1n1)pdm09; a(h3n2; ace2; acid; acute; addition; adults; african; aiv; analysis; animals; auc; authors; avian; bacterial; bacterial pneumonia; cases; cd5l; changes; characterized; chikungunya; chikv; china; chinese; clinical; close; complete; considered; contact; control; coronavirus; correlation; covid-19; cross; csf; current; daa; daily; data; day; deaths; diagnosis; different; direct; dna; domestic; ecmo; eiv; end; epidemic; epidemiological; equines; errors; failure; farming; feb; fever; fig; gene; genetic; genome; genotype; global; gram; h3n8; hbcab; hbsag; hbv; hcv; health; hepatitis; high; higher; hiv; hospital; hubei; human; humidity; icu; identification; increase; infected; infection; influenza; influenza virus; information; interest; isolated; journal; levels; lineage; low; mainland; meningitis; minion; mortality; mouse; national; ncov; negative; new; non; novel; number; outbreak; p72; parameters; pathogen; patients; pneumonia; positive; potential; poultry; present; previous; protein; provinces; rate; reactivation; reads; recent; receptor; recombination; regions; research; residues; resistance; respiratory; result; rrna; samples; science; seasonal; seasonality; sequences; sequencing; serum; severe; southernmost; species; strains; studies; study; subtype; supplementary; surveillance; swine; system; table; temperature; therapy; time; total; transmission; treatment; viral; virus; viruses; work; xxvi; years; yunnan cache: cord-266105-8avkjc84.txt plain text: cord-266105-8avkjc84.txt item: #41 of 79 id: cord-267709-i2loz1xb author: Li, Tongya title: Human Hepatitis B Virus Core Protein Inhibits IFNα-Induced IFITM1 Expression by Interacting with BAF200 date: 2019-05-09 words: 6955 flesch: 46 summary: However, overexpressed HBc had little observed impact on the recovery of HBV DNA levels, implying that IFITM1 is not the only primary IFNα-inducible ISG that suppresses HBV DNA replication. HBV infection could cause acute and chronic Hepatitis B (CHB), which can progress to cirrhosis and hepatocellular carcinoma, leading to high mortality rates worldwide. keywords: anti; antibodies; antibody; antiviral; assays; baf180; baf200; binding; blot; catalog; cells; complexes; control; core; data; dna; effect; endogenous; expression; figure; flag; genes; genome; hbc; hbv; hepaad38; hepatitis; hepatocytes; hepg2; hepg2 cells; hepg2.2.15; host; human; ifitm1; ifnα; immune; induced; infected; infection; innate; interaction; interferon; levels; medium; mrna; mtt; ntcp; overexpressed; pathway; pbaf; pcmv; pgc; proliferation; protein; replication; response; results; signaling; stability; stat1; stimulation; supernatants; transcription; transfection; treatment; usa; vector; viral; virus; vitro; western cache: cord-267709-i2loz1xb.txt plain text: cord-267709-i2loz1xb.txt item: #42 of 79 id: cord-274080-884x48on author: Rumlová, Michaela title: In vitro methods for testing antiviral drugs date: 2018-06-30 words: 18015 flesch: 26 summary: Virus-encoded methyltransferases have been identified and characterized in flaviviruses such as Zika virus Coutard et al., 2017; Duan et al., 2017; Munjal et al., 2017; Zhao et al., 2017) , West Nile virus, and dengue virus (Dong et al., 2012) ; rhabdoviruses such as vesicular stomatitis virus (VSV) (Rahmeh et al., 2009 ); coronaviruses such as SARS (Wang et al., 2015b) ; and roniviruses (Zeng et al., 2016) . Alternatively, cleavage products may be monitored by analysis of proteolytic products by mass spectrometric methods (Hu et al., 2015; Joshi et al., 2017; Lathia et al., 2011; Rumlová et al., 2003) , analytical HPLC (Teruya et al., 2016) , or electrochemical methods based on the difference in penetration of substrate and cleavage products through the membrane of a polyionselective sensor (Gemene and Meyerhoff, 2011; Han et al., 1996) . keywords: acid; activation; activities; activity; adenoviruses; adp; analysis; antibodies; antibody; antiviral; approach; assay; assembly; atpase; available; binding; biochemical; budding; c virus; capsid; ccr5; cell; cellular; changes; characterization; cleavage; clercq; clinical; common; complex; complexes; components; compounds; conditions; contrast; core; coronavirus; cov; cycle; cytoplasm; cytosol; dengue; dependent; design; detection; determination; development; different; direct; disassembly; discovery; dna; domain; drug; dsdna; early; east; ebola; encode; endocytosis; endosomal; endosomes; entry; envelope; enveloped viruses; enzymes; escape; escrt; et al; example; expression; factors; fields; fig; flaviviruses; fluorescence; formation; furin; fusion; gag; genetic; genome; genomic; glycoproteins; golgi; gp41; grna; hbv; hcv; helenius; helicase; hepatitis; herpesviruses; high; highthroughput; hiv-1; host; host cell; hts; human; icosahedral; identification; immunodeficiency; infected; infection; influenza; influenza virus; inhibition; inhibitors; insights; integrase; integration; interactions; intracellular; kinase; knipe; large; late; layer; leukemia; life; like; lipid; luciferase; machinery; majority; mass; material; matrix; maturation; mechanism; membrane; mers; method; methylation; methyltransferase; middle; modified; molecular; molecule; monitoring; mrna; multiple; murine; nanoparticles; new; novel; npc; ns3; nuclear; nucleic; nucleocapsid; nucleus; numerous; packaging; particles; pathways; peptide; phase; phosphorylation; plasma; polarization; poliovirus; polymerase; pore; positive; potential; poxviruses; presence; primary; process; processing; production; products; protease; protein; proteolytic; purified; pyrophosphate; quantitative; reaction; real; receptor; recombinant; release; replication; reporter; resistant; respiratory; retroviral; retroviruses; reverse; review; rna; rna polymerase; rna viruses; role; sars; screening; selective; sensitive; shell; signaling; simplex; single; sites; size; small; specific; stages; steps; stomatitis; strand; structural; study; substrate; surface; syndrome; synthesis; system; target; targeting; techniques; terminal; throughput; time; tqon; transcribed; transcriptase; transcription; translation; transport; type; tyrosine; uncoating; unique; vaccinia; vesicles; vesicular; viral; viral proteins; viral rna; virions; virus; virus entry; virus replication; virus type; viruses; vivo; wang; wang et; zika cache: cord-274080-884x48on.txt plain text: cord-274080-884x48on.txt item: #43 of 79 id: cord-275104-imqmyqhz author: Fioravanti, Jessica title: Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology date: 2017-09-30 words: 3971 flesch: 43 summary: 13 Serum IL-10 was not detectable until CD8 + T cells accumulated in the liver and its appearance coincided with the onset of a necroinflammatory liver disease (Fig. 1A) , suggesting that this cytokine might have been produced by virus-specific CD8 T E upon hepatocellular Ag recognition. key: cord-275104-imqmyqhz authors: Fioravanti, Jessica; Di Lucia, Pietro; Magini, Diletta; Moalli, Federica; Boni, Carolina; Benechet, Alexandre Pierre; Fumagalli, Valeria; Inverso, Donato; Vecchi, Andrea; Fiocchi, Amleto; Wieland, Stefan; Purcell, Robert; Ferrari, Carlo; Chisari, Francis V.; Guidotti, Luca G.; Iannacone, Matteo title: Effector CD8+ T cell-derived interleukin-10 enhances acute liver immunopathology date: 2017-09-30 journal: Journal of Hepatology DOI: 10.1016/j.jhep.2017.04.020 sha: doc_id: 275104 cord_uid: imqmyqhz Background & Aims Besides secreting pro-inflammatory cytokines, chemokines and effector molecules, effector CD8+ T cells that arise upon acute infection with certain viruses have been shown to produce the regulatory cytokine interleukin (IL)-10 and, therefore, contain immunopathology. keywords: -derived; acute; addition; analysis; anti; apoptosis; blockade; cd8; cd8 t; cells; chimpanzee; competent; cor93; cytokine; data; disease; effector; expression; fig; flow; hbv; hepatitis; hepatocellular; human; ifn; il-10; il-10ra; il-2; il10; immunopathology; induced; infected; infection; intrahepatic; liver; mice; mouse; number; pathogenesis; patients; peptide; replication; results; role; serum; specific; t e; test; transfer; transgenic; viral; virus cache: cord-275104-imqmyqhz.txt plain text: cord-275104-imqmyqhz.txt item: #44 of 79 id: cord-275795-ee7qyw5h author: Monette, Anne title: T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders date: 2018-10-24 words: 28288 flesch: 24 summary: As cellular immunity to VZV wanes in the elderly and immunocompromised populations, latent VZV becomes reactivated and causes zoster (i.e., shingles, herpes zoster), which is usually associated with chronic pain but also numerous other serious neurological and ocular disorders, as well as multiple visceral and gastrointestinal disorders, including ulcers, hepatitis, and pancreatitis (Gershon et al., 2015; Gilden et al., 2010) . Transmission to humans is via the rodent host Mastomys natalensis (Mccormick et al., 1987) . keywords: 17d; absence; activation; activity; acute; adaptive; adaptive immune; adenovirus; adults; africa; agents; alphaviruses; analysis; antibodies; antibody; antibody responses; antigen; antiviral; associated; attenuated; available; b cells; b virus; baize et; bbb; blood; brain; burden; capsid; cases; cause; cchfv; cd4; cd8 þ; cell immune; cell immunity; cell responses; cellular; cellular immune; central; characterization; characterized; children; chronic; class; clearance; clinical; clones; cns; common; complement; complex; congo; conserved; control; correlates; countries; crimean; critical; cross; ctls; current; cytokine; cytotoxic; cytotoxicity; days; deaths; dengue; dengue virus; denv; dependent; design; development; diameter; diamond; disease; disorders; dissemination; distinct; dna; doses; early; ebola; ebola virus; ebov; effective; effector; efficacy; emergence; encephalitis; encephalitis virus; encodes; endemic; entry; envelope; epidemics; epidemiology; epitopes; equine; eradication; estimated; et al; evasion; evidence; exanthems; existing; exposure; expression; factors; family; fatal; fatality; fever; fever virus; fisher; flaviviruses; fusion; future; gamma; ganglia; gastroenteritis; generation; genome; genus; gershon; global; gps; group; hadv; hav; hbv; hcc; hcv; hdv; healthy; hemorrhagic; hepatitis; herpes; hev; high; hiv; hla; hoch; hospitalization; host; hpiv; human; human t; humoral; ifn; igg; illness; immune; immune responses; immunity; immunization; immunocompetent; immunocompromised; immunogenicity; important; inactivated; increases; individuals; induced; induction; infants; infected; infected cells; infection; inflammatory; influenza; influenza virus; innate; interferon; japanese; large; lassa; lasv; later; lethal; levels; licensed; lifelong; live; long; lower; lymphocytes; macrophages; main; major; majority; matrix; mccormick; measles; measles virus; mechanisms; member; membrane; memory; memory t; mev; mice; military; model; morbidity; mortality; mosquito; multiple; natural; nervous; neurological; neurons; neutralizing; new; nile; non; ns3; numerous; observations; organ; outbreaks; paessler; parainfluenza; particles; pathogenesis; pathogens; patients; pediatric; persistence; person; pneumonia; polymerase; polyprotein; populations; potential; prevention; primary; programs; protection; proteins; rabies; rabv; rapid; rash; rates; recent; receptor; recognition; recombinant; recovery; replication; research; respiratory; responses; responsible; results; review; risk; rna; robust; role; rotavirus; route; rsv; rubella; rubella virus; safety; sense; serotypes; severe; shin et; significant; single; skin; smallpox; specific; specific cd8; spread; states; strains; strategies; strong; structural; studies; study; subsets; surface; survivors; symptoms; syncytial; syncytial virus; system; systemic; t cells; targeting; term; tick; time; tissue; tnf; tract; transmission; treatment; tropism; type; united; vaccinated; vaccination; vaccine; vaccinia; vacv; varicella; variola; varv; vascular; vectors; veev; venezuelan; viral; virus; virus infection; virus vaccine; viruses; vzv; watson; west; white et; world; worldwide; years; yellow; yfv; zoster; zoster virus; þ t cache: cord-275795-ee7qyw5h.txt plain text: cord-275795-ee7qyw5h.txt item: #45 of 79 id: cord-276565-vkbu581j author: He, Qing title: Clinical Characteristics of COVID-19 Patients With Pre-existing Hepatitis B Virus Infection: A Multicenter Report date: 2020-09-11 words: 671 flesch: 34 summary: In the COVID-HBV-CHESS study, we analyzed the clinical characteristics of COVID-19 patients with pre-existing HBV infection for the first time, to our best knowledge; only by multicenter analysis can we follow-up COVID-19 with underlying liver disease, such as HBV infection. Thus, it is indispensable to study the clinical characteristics of COVID-19 patients with preexisting HBV infection. keywords: clinical; coronavirus; covid-19; disease; hbv; hepatitis; hospital; infection; liu; liver; patients; respiratory; sars; study; wang; zhang cache: cord-276565-vkbu581j.txt plain text: cord-276565-vkbu581j.txt item: #46 of 79 id: cord-280643-n8qjorqk author: Wu, Kai-Lang title: Inhibition of Hepatitis B virus gene expression by single and dual small interfering RNA treatment date: 2005-04-26 words: 3782 flesch: 46 summary: To study the effects of dual RNAi on HBV gene expression in a cell culture model, we used a derivative of the human HepG2 hepatoma cell line, HepG2.2.15, which has been stably transformed with several copies of the HBV genome and used as an in vitro model for HBV replication. The effects of dual siRNA system on HBV gene expression were investigated in this study. keywords: approach; bel-7402; cells; control; core; dna; dual; effects; expression; fig; fusion; gene; genome; hbs; hbsxsirna; hbv; hbx; hepatitis; hepg2.2.15; human; inhibition; interference; lane; levels; luciferase; molecules; mrna; pcr; plasmid; plucf; psliencer-2.1; replication; results; rnai; sirna; sites; study; system; target; transfection; treatment; vector; viral; virus cache: cord-280643-n8qjorqk.txt plain text: cord-280643-n8qjorqk.txt item: #47 of 79 id: cord-285505-8norumv6 author: Vere Hodge, R. Anthony title: Meeting report: 27th International conference on antiviral research, in Raleigh, NC, USA date: 2014-09-16 words: 10298 flesch: 57 summary: These are followed by brief summaries of the keynote addresses and the three mini-symposia on 'Hepatitis B virus', 'Research Triangle Park' and 'Challenges in HIV infection, treatment and prevention'. Although this patient continues to have no sign of HIV infection, this is hardly a viable treatment option for most HIV-infected patients. keywords: active; activity; adrian; analog; antiviral; approach; art; assay; award; bcx4430; bdcrb; cancer; carolina; cccdna; cells; chronic; clinical; combination; compounds; contrast; core; couples; culture; cure; current; daily; days; different; disease; dna; doses; dosing; drug; early; effective; example; fig; form; ftc; good; group; gs-6620; hbv; hcmv; hcv; hdv; hepatitis; hepatocytes; high; higher; hiv; hntcp; human; icar; increase; infected; infection; inhibitor; integrated; latent; levels; liver; load; long; low; major; maribavir; mitochondrial; model; monkeys; myron; new; north; novel; nuc1; nucleotide; oral; patients; phase; piet; plasma; polymerase; possible; potential; prep; prevention; prodrug; progress; protection; protein; rate; reduction; replication; research; resistance; rna; single; siv; sofosbuvir; strains; studies; study; subjects; synthesis; system; taf; target; tdf; tfv; therapy; time; tissues; transcription; transmission; treatment; trial; triphosphate; university; usa; use; viral; virus; work; years cache: cord-285505-8norumv6.txt plain text: cord-285505-8norumv6.txt item: #48 of 79 id: cord-286334-d9v5xtx7 author: Li, Rui title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 words: 12986 flesch: 42 summary: Several strategies may help reduce the threat of AIV to equines, including reducing exposure of equines to poultry, birds, and other hosts of IAV, especially animals with clinical signs of influenza virus infection; monitoring AIV prevalence in domestic poultry around equines and routinely vaccinating domestic poultry with AIV vaccines; vaccinating susceptible equines with EI vaccines, especially farming equines in close contact with domestic poultry; and monitoring the prevalence of multiple AIV subtypes in equines, not merely that of those restricted to H3N8 subtype. 5 Low humidity and temperature increased the stability of influenza virus in aerosols and on surfaces. keywords: 16s; 6xi; a(h1n1)pdm09; a(h3n2; ace2; acid; acute; addition; adults; african; aiv; analysis; animals; auc; authors; avian; bacterial; bacterial pneumonia; cases; cd5l; changes; characterized; chikungunya; chikv; china; chinese; clinical; close; complete; considered; contact; control; coronavirus; correlation; covid-19; cross; csf; current; daa; daily; data; day; deaths; diagnosis; different; direct; dna; domestic; ecmo; eiv; epidemic; epidemiological; equines; errors; failure; farming; feb; fever; fig; gene; genetic; genome; genotype; global; gram; h3n8; hbcab; hbsag; hbv; hcv; health; hepatitis; high; higher; hiv; hospital; hubei; human; humidity; icu; identification; increase; infected; infection; influenza; influenza virus; information; interest; isolated; journal; levels; lineage; low; mainland; meningitis; minion; mortality; mouse; national; ncov; negative; new; non; novel; number; outbreak; p72; parameters; pathogen; patients; pneumonia; positive; potential; poultry; present; previous; protein; provinces; rate; reactivation; reads; recent; receptor; recombination; regions; research; residues; resistance; respiratory; result; rrna; samples; science; seasonal; seasonality; sequences; sequencing; serum; severe; southernmost; species; strains; studies; study; subtype; supplementary; surveillance; swine; system; table; temperature; therapy; threat; time; total; transmission; treatment; viral; virus; viruses; work; xxvi; years; yunnan cache: cord-286334-d9v5xtx7.txt plain text: cord-286334-d9v5xtx7.txt item: #49 of 79 id: cord-286719-1xjmlwqr author: Draz, Mohamed Shehata title: Applications of gold nanoparticles in virus detection date: 2018-02-15 words: 19000 flesch: 33 summary: In addition, we provide a general summary of the contributions of AuNPs to the mainstream methods of virus detection, technical measures, and recommendations required in guidance toward commercial in-field applications. Toward this endeavor and beyond the pitfalls of current immunological and molecular techniques commonly applied to virus detection, several new approaches based on nanoparticles (NPs) have recently been developed. keywords: acid; activity; addition; africa; aggregation; amplification; antibodies; antibody; antigen; applications; applied; approaches; area; array; assay; aunps; available; b virus; barcode; biomolecules; biotin; cancer; capture; catalytic; cause; cells; change; characteristics; chip; chronic; clinical; colorimetric; colorimetric detection; common; concentration; conjugates; conjugation; control; core; coronavirus; current; cy3; deposition; detected; detection; detection limit; detection methods; detection techniques; developed; development; diagnostic; different; direct; diseases; dls; dna; dna detection; dna probes; drugs; early; ebola; effective; efficient; electrical; electrochemical; electrochemical detection; electrode; enhanced; enhancement; enzyme; family; fever; fig; flow; fluorescence; fluorometric; form; fret; functions; genera; genome; genus; global; gold; h1n1; hav; hbsag; hbv; hbv dna; hcmv; hcv; health; hepatitis; herpes; high; hiv; hpv; hrp; human; hybridization; icp; immobilized; immunoassay; immunological; important; infection; influenza; international; kaposi; known; kshv; label; large; lateral; light; like; limit; lspr; magnetic; main; management; metal; methods; molecular; molecular detection; multiple; nanoparticles; new; novel; nucleic; numerous; outbreaks; papillomavirus; pcr; plasmon; positive; presence; probes; properties; proteins; protocol; qcm; quenching; raman; range; rapid; reaction; red; reduction; reported; resonance; respiratory; results; review; rna; rvfv; sandwich; sarcoma; sars; scanometric; scanometric detection; scattering; scheme; sense; sensing; sensitive; sensitive detection; sensitivity; sequences; serological; sers; shape; signal; significant; silver; similar; simple; single; size; species; specific; specific dna; specificity; spherical; ssdna; stability; staining; step; streptavidin; stripping; structures; studies; surface; syndrome; synthesis; systems; table; target; target dna; target virus; taxonomy; techniques; test; testing; time; traditional; treatment; types; vaccine; viral; virus; virus detection; virus dna; viruses; wide; world cache: cord-286719-1xjmlwqr.txt plain text: cord-286719-1xjmlwqr.txt item: #50 of 79 id: cord-287151-4hlvrfeh author: Steinmann, J title: Surrogate viruses for testing virucidal efficacy of chemical disinfectants date: 2004-04-30 words: 2914 flesch: 38 summary: Besides volume ratios and soil load, the choice of test viruses is one of the most important question in addressing inactivation experiments. In Germany, poliovirus type 1 (vaccine strain LSc 2ab, formerly strain Mahoney/Pette), adenovirus type 5 (formerly adenovirus type 2), papovavirus strain 777 and vaccinia virus strain Elstree are test viruses for hand-, surface-and instrument disinfectant. keywords: bovine; bvdv; calicivirus; cell; chemical; culture; dhbv; disinfectants; disinfection; dna; duck; efficacy; europe; evaluation; experiments; family; fcv; feline; genome; genus; hbv; hcv; hepatitis; hepatocytes; high; human; important; inactivation; infection; like; model; norovirus; norwalk; nosocomial; outbreaks; past; pcr; quantitative; single; small; studies; surrogate; suspension; testing; tests; transmission; viral; virucidal; virus; viruses; vivo cache: cord-287151-4hlvrfeh.txt plain text: cord-287151-4hlvrfeh.txt item: #51 of 79 id: cord-293646-d4qcckh1 author: Meanwell, Nicholas A. title: Chapter 22. Non-HIV antiviral agents date: 2003-12-31 words: 4188 flesch: 38 summary: The development of the HCV replicon system and its application to screening for antiviral agents provided tangible benefit with the disclosure of mechanistically and structurally diverse HCV inhibitors. The development of the first HCV replicon system in 1998 and its application to screening for antiviral agents is beginning to provide tangible benefit with the disclosure of mechanistically and structurally diverse HCV inhibitors. keywords: 3tc; active; activity; adefovir; agents; analogues; antiviral; biln-2061; cell; clinical; culture; derivatives; development; dna; dose; ec50; efficacy; hbv; hcmv; hcv; hepatitis; hiv; host; hsv; human; infections; influenza; inhibitors; levels; load; moiety; molecule; mortality; non; ns3; nucleoside; oral; patients; polymerase; potent; potential; protease; protein; recent; reduction; related; replication; replicons; resistant; respiratory; rna; rsv; sars; second; september; series; serine; significant; small; structural; therapy; treatment; trials; viral; virus; viruses cache: cord-293646-d4qcckh1.txt plain text: cord-293646-d4qcckh1.txt item: #52 of 79 id: cord-296222-w5m23ikh author: Hu, Song title: Hepatitis B virus upregulates host expression of α-1,2-mannosidases via the PPARα pathway date: 2016-11-21 words: 3829 flesch: 48 summary: There are glycosylation sites on the surface of HBV envelope proteins, which could be glycosylated by the host [12] . To investigate the association between the expression of α-1,2mannosidase and virus secretion, we assessed virus secretion in the cell culture supernatants of various HBV cell lines. keywords: ad38; anti; cells; chronic; class; demannosylation; dilution; effects; envelope; expression; figure; glycosylation; gw9662; hbs; hbv; hepatitis; hepg2; host; immune; increase; infection; levels; lines; liver; man1c1; mannose; mannosidase; mk886; pathway; patients; pparα; pres2; previous; protein; ptt22; sign; studies; study; tet; viral; virus; α-1,2 cache: cord-296222-w5m23ikh.txt plain text: cord-296222-w5m23ikh.txt item: #53 of 79 id: cord-296979-8r851j4t author: Zhong, Ying title: Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo date: 2017-10-31 words: 6777 flesch: 44 summary: Finally, we silenced the target genes and a control gene by RNA interference (RNAi) to detect effects of the silencing of these genes on transcriptional level of HBV genes to determine whether host genes participate in regulation of HBV gene transcription. The transcription levels of HBV genes between the test and control groups are significantly different (P < 0.05), which suggested that in the test group the target genes have been silenced by RNAi and participated in transcriptional regulation of HBV genes, causing the change of HBV gene transcription levels. keywords: amplification; analysis; average; cdna; cell; cell embryos; change; clones; control; control gene; control group; csh2; current; cy3; cy5; data; development; differential; early; effects; eif4g2; embryonic; embryos; expression; factors; family; fertilization; fold; forward; free; gene transcription; genes; genome; group; hamster; hbv; hbv gene; hbv s; hepatitis; host; human; identity; infection; length; levels; medical; min; negative; non; oocyte; pcbd2; pcr; plasmid; positive; protein; ratio; regulation; research; reverse; rna; rnai; samples; sequences; significant; silencing; smart; specific; sperm; ssh; stage; study; subtraction; table; takara; target; target genes; test; total; transcription; transfected; transmission; ttn; value; viral; virus; vitro; zona cache: cord-296979-8r851j4t.txt plain text: cord-296979-8r851j4t.txt item: #54 of 79 id: cord-297077-p604vvbi author: Tai, Dar‐In title: A global perspective on hepatitis B‐related single nucleotide polymorphisms and evolution during human migration date: 2017-11-06 words: 3147 flesch: 40 summary: Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between Epidemiology and prevention of hepatitis B virus infection Natural history of chronic hepatitis B virus infection in Taiwan: studies of hepatitis B virus DNA in serum Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma Trained immunity in newborn infants of HBV-infected mothers Relative roles of HBsAg seroclearance and mortality in the decline of HBsAg prevalence with increasing age A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population New loci associated with chronic hepatitis B virus infection in Han Chinese Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean A genome-wide association study identified new variants associated with the risk of chronic hepatitis B Association between HLA variations and chronic hepatitis B virus infection in Saudi Arabian patients A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B Association of CD40 -1C/T polymorphism in the 5 0 -untranslated region with chronic HBV infection Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C Impaired induction of interleukin 28B and expression of interferon k 4 associated with nonresponse to interferon-based therapy in chronic hepatitis C Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4) Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3 Evaluation of human leukocyte antigen-A (HLA-A), other non-HLA markers on chromosome 6p21 and risk of nasopharyngeal carcinoma The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove Genomes Project Consortium A global reference for human genetic variation Timing the first human migration into eastern Asia Late Pleistocene climate drivers of early human migration To understand the evolution of HBV‐related single nucleotide polymorphisms (SNPs) and to correlate these SNPs with chronic HBV infection among different populations, we conducted a global perspective study on hepatitis‐related SNPs. keywords: africa; allele; antigen; asia; association; changes; china; chronic; cytokine; data; differences; different; east; expression; fig; frequency; genetic; genome; genotypes; global; hbsag; hbv; hepatitis; high; hla; human; ifnl4; immune; infection; interferon; migration; new; patients; persistent; populations; prevalence; response; seroconversion; snps; south; strategy; study; survival; table; tolerance; virus; wide cache: cord-297077-p604vvbi.txt plain text: cord-297077-p604vvbi.txt item: #55 of 79 id: cord-300642-c7adeis1 author: Lai, Andrew SH title: Viral nephropathy date: 2006 words: 4748 flesch: 31 summary: Taiwan Childhood Hepatoma Study Group Safety of immunisation and adverse events following vaccination against hepatitis B Membranoproliferative glomerulonephritis associated with hepatitis C virus infection Immunological disorders in C virus chronic active hepatitis: a prospective casecontrol study Hepatitis C, cryoglobulinemia, and cirrhosis: a meta-analysis Secondary membranoproliferative glomerulonephritis Hepatitis C virus infection and acute or chronic glomerulonephritis: an epidemiological and clinical appraisal Renal involvement in hepatitis C infection: cryoglobulinemic glomerulonephritis Long-term predictors of survival in essential mixed cryoglobulinemic glomerulonephritis Membranous glomerulonephritis associated with hepatitis C virus infection: case report and literature review Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus: Renal infection with BK virus affects kidney allograft recipients, leading to renal dysfunction and sometimes graft loss. keywords: acute; adults; african; agent; antigen; areas; cases; children; chronic; clinical; complexes; course; cryoglobulinemia; diagnosis; direct; disease; dna; failure; fever; focal; forms; fsgs; glomerular; glomerulonephritis; glomerulopathy; glomerulosclerosis; group; hbv; hcv; hepatitis; high; hiv; hivan; idiopathic; immune; infected; infection; interferon; kidney; laboratory; lamivudine; levels; liver; manifestations; mcgn; mechanisms; membranous; mesangial; mixed; molecular; multiorgan; nephropathy; nephrotic; pathology; patients; present; prevalence; proliferative; proteinuria; pvb19; remission; renal; replication; reported; ribavirin; rna; role; segmental; serum; severe; syndrome; testing; therapy; treatment; tubular; type; viral; virus cache: cord-300642-c7adeis1.txt plain text: cord-300642-c7adeis1.txt item: #56 of 79 id: cord-305085-bv7udg9k author: Lawrence, Robert M. title: Chapter 13 Transmission of Infectious Diseases Through Breast Milk and Breastfeeding date: 2011-12-31 words: 45867 flesch: 41 summary: Experience from the Finnish HPV family study Streptococcal toxic shock syndrome, including necrotizing fasciitis and myositis Late-onset septicemia in a Norwegian national cohort of extremely premature infants receiving very early full human milk feeding Hepatitis A outbreak in a neonatal intensive care unit: Risk factors for transmission and evidence of prolonged viral excretion among preterm infants Characterization of a novel corona virus associated with severe acute respiratory syndrome Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease Attempts to detect RNA tumour virus in human milk Is breast milk collected at home suitable for raw consumption by neonates in Brizilian public neonatal intensive care units? Prevalence of HIV-1 DNA and p24 antigen in breast milk and correlation with maternal factors Follow-up of transmission of hepatitis C to babies of human immunodeficiency virus-negative women: The role of breastfeeding in transmission Occurrence of acute diarrhea in atopic and nonatopic infants: role of prolonged breast-feeding An outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit Hospital transmission of community acquired methicillin-resistant Staphylococcus aureus among postpartum women Removal of inhibitors against RNA-directed DNA polymerase activity in human milk Effect of human milk on mouse mammary tumor virus Human papillomavirus DNA detected in breast milk Control of a cluster of a community-associated methicillin-resistant Stahpylococcus aureus in neonatology Immunoglobulin prophylaxis against milkborne transmission of human T cell leukemia virus type 1 in rabbits Chlamydial infections Pregnancy and pulmonary tuberculosis Possible breast milk transmission of group B streptococcal infection Evidence for transmission of lymphocyte responses to tuberculin by breast-feeding, Lancet I:529 Toxic shock syndrome Detection of Borrelia burgdorferi DNA by PCR in the urine and breast milk of patients with Lyme borreliosis Prevention of perinatal group B streptococcal disease. One case of brucellosis in an infant caused by breast milk transmission, with B. melitensis isolated from the breast milk, before antibiotic treatment was given to the mother has been documented. keywords: absence; acceptable; acquisition; active; acute; additional; adults; africa; age; agents; airborne; analysis; antibodies; antibody; antigen; antiretroviral; appropriate; areas; associated; association; asymptomatic; aureus; authors; available; bacterial; benefits; birth; blood; bottle; botulism; breast cancer; breast infection; breast lesions; breast milk; breastfed; breastfed infants; breastfeeding; brucellosis; c virus; care; careful; cases; cause; cells; cesarean; chapter; children; chronic; clinical; close; cmv; collection; colonization; colonized; colostrum; committee; common; community; complete; congenital; congenital infection; contact; contamination; continued; control; countries; course; culture; culturing; cytomegalovirus; cytomegalovirus infection; data; days; death; decrease; delivery; dengue; dengue virus; developed; development; diagnosis; diarrhea; different; difficult; direct; discussion; disease; dna; documented; dose; droplet; duration; e.g.; early; ebv; effect; effective; empiric; endemic; epidemiologic; et al; evaluation; evidence; exclusive; exclusive breastfeeding; exposure; expressed; factors; fetus; fever; fever virus; fluids; follow; formula; free; gbs; general; greater; group; hav; hbv; hcv; hdv; health; hemorrhagic; hepatitis; herpes; hev; hgv; high; higher; history; hiv; hiv infection; hiv transmission; hiv-1; home; hospital; hospitalized; hours; household; hpv; htlv; human breast; human milk; humans; igm; illness; illnesses; immune; immunization; immunodeficiency; immunodeficiency virus; important; incidence; increased; individuals; infancy; infant transmission; infants; infants younger; infected; infection; infection control; information; intensive; interventions; intrapartum; invasive; involvement; isolation; isoniazid; laboratory; lack; lactating; lactation; large; late; lesions; leukemia; life; likely; literature; load; low; lower; lyme; lymphotropic; malaria; management; mastitis; maternal; maternal infection; measles; medical; methicillin; mild; milk samples; months; morbidity; mortality; mother; mrsa; mumps; negative; neonatal; neonates; newborn; nile; nile virus; number; nursery; observation; occurrence; older; ongoing; onset; oral; organism; outbreaks; patients; pcr; perinatal; period; person; pneumonia; poliovirus; positive; positive mothers; possible; postnatal; postnatal infection; postnatal transmission; postpartum; potential; precautions; pregnancy; pregnant; premature; premature infants; prenatal; presence; preterm; prevalence; prevention; primary; products; prolonged; prophylaxis; protective; rabies; range; rare; rash; rates; reasonable; recent; recommendations; regimens; related; relative; reported; reports; resistant; respiratory; response; results; risk; role; rotavirus; routine; rsv; saliva; samples; sars; secondary; secretions; separation; sequelae; seropositive; serum; severe; severity; shock; short; significant; similar; single; situations; skin; smallpox; source; south; species; specific; spread; standard; staphylococcus; states; streptococcal; studies; study; subsequent; support; survival; symptoms; syndrome; syphilis; term; testing; therapy; time; timing; toxin; tract; transmammary; transmission; transmission breast; transmission rate; transplacental; treatment; tst; ttv; tuberculosis; type; uncommon; united; urine; use; vaccination; vaccine; vaccine virus; vaccinia; varicella; vertical transmission; viral; virus; virus infection; virus transmission; virus type; viruses; weaning; weeks; west; women; world; years; yellow; younger; zidovudine; zoster; zoster virus cache: cord-305085-bv7udg9k.txt plain text: cord-305085-bv7udg9k.txt item: #57 of 79 id: cord-307044-4czeehkq author: Liu, Jiaye title: Longitudinal Changes of Liver Function and Hepatitis B Reactivation in COVID‐19 Patients with Pre‐existing Chronic HBV Infection date: 2020-08-06 words: 3520 flesch: 43 summary: Chronic HBV infection was determined on the basis of testing positive for HBsAg and/or HBV DNA at hospital admission and medical history of chronic HBV infection. However, to the best of our knowledge, no studies had been carried out on the impact of chronic HBV infection on the disease progression and liver function changes of COVID-19 patients, and how the SARS-CoV-2 infection in turn affects the course of chronic HBV infection. keywords: abnormal; admission; alt; ast; baseline; biochemistries; chronic; chronic hbv; clearance; course; cov-2; covid-19; days; difference; disease; dna; figure; function; ggt; group; hbv; hbv infection; hepatitis; hospital; hospitalization; infection; levels; liver; median; non; patients; progression; reactivation; risk; sars; severe; study; tbil; test; time; treatment; vs. cache: cord-307044-4czeehkq.txt plain text: cord-307044-4czeehkq.txt item: #58 of 79 id: cord-308382-h8ldbzip author: Lin, Serena Y. C. title: Origin and dissemination of hepatitis B virus genotype C in East Asia revealed by phylodynamic analysis and historical correlates date: 2018-10-17 words: 2594 flesch: 21 summary: 10 In Mainland China, genotype C is predominant in the Northern part of China (Beijing, Xingjiang and Gansu), while genotype B is prevalent in the Central and Eastern part of China (Hunan and Fujian), with an overall prevalence of 41% for genotype B and 53% for genotype C. 11 Similarly in Taiwan, where HBV genotype B is the most prevalent (68%), genotype C still accounts for almost one-third of the infections (32%). WHO guidance on development of influenza vaccine reference viruses by reverse genetics Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes Molecular epidemiological study of hepatitis B virus infection in two different ethnic populations from the Solomon Islands Hepatitis B virus genotypes Hepatitis B virus genotypes in the United States: results of a nationwide study A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype Molecular characterization of hepatitis B virus and a 9-year clinical profile in a patient infected with genotype I Distribution of hepatitis B virus genotypes in Korea Hepatitis B virus genotype C is associated with more severe liver fibrosis than genotype B Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan Geographic distribution, virologic and clinical characteristics of hepatitis B virus genotypes in China Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection Genotype C of hepatitis B virus can be classified into at least two subgroups A novel variant genotype C of hepatitis B virus identified in isolates from Australian Aborigines: complete genome sequence and phylogenetic relatedness Hepatitis B virus genotype C takes a more aggressive disease course than hepatitis B virus genotype B in hepatitis B e antigen-positive patients Viral genotype and hepatitis B virus DNA levels are correlated with histological liver damage in HBeAg-negative chronic hepatitis B virus infection Hepatitis B virus genotype A is more often associated with severe liver disease in northern India than is genotype D Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers Screening for chronic hepatitis B among Asian/Pacific Islander populations Bayesian estimates of the evolutionary rate and age of hepatitis B virus Molecular evolution of hepatitis B virus over 25 years Hepatitis B virus genotyping: current methods and clinical implications MEGA6: molecular evolutionary genetics analysis version 6.0 Epidemiological serosurvey of hepatitis B in China-declining HBV prevalence due to hepatitis B vaccination Hepatitis B vaccinations among Koreans: Results from 2005 Korea National Cancer Screening Survey Epidemiology of Hepatitis B Virus in Japan, especially in Nagasaki Epidemiology of hepatitis B virus infection in the Asia-Pacific region Epidemiology of hepatitis B in the United States Estimation of levels of gene flow from DNA sequence data Improving Bayesian population dynamics inference: a coalescentbased model for multiple loci Improving the accuracy of demographic and molecular clock model comparison while accommodating phylogenetic uncertainty Make the most of your samples: Bayes factor estimators for high-dimensional models of sequence evolution Bayesian phylogenetics with BEAUti and the BEAST 1.7 SPREAD: spatial phylogenetic reconstruction of evolutionary dynamics Viral phylodynamics and the search for an 'effective number of infections' SARS epidemic area Severe acute respiratory syndrome coronavirus sequence characteristics and evolutionary rate estimate from maximum likelihood analysis Cultural Revolution memoirs written and read in English: Image formation, reception and counternarrative: Thesis(Ph.D.)-University of Minnesota Life and Death in Shanghai World Health Organization changes Hong Kong, Guangdong travel recommendations Summary of probable SARS cases with onset of illness from 1 SARS in healthcare facilities Control measures for severe acute respiratory syndrome (SARS) in Taiwan Molecular evolution and phylodynamics of acute hepatitis B virus in Japan Characterising two-pathogen competition in spatially structured environments keywords: analysis; asia; available; bayesian; bottleneck; china; chronic; countries; country; data; demographic; disease; east; epidemic; evolutionary; factors; genotype; hbv; hepatitis; history; human; infection; japan; korea; lineages; major; model; molecular; origin; phylogenetic; population; prevalence; ratio; sampling; sars; sequences; set; spatial; study; taiwan; time; usa; viral; virus cache: cord-308382-h8ldbzip.txt plain text: cord-308382-h8ldbzip.txt item: #59 of 79 id: cord-312965-5hcb15xc author: Qi, Yan-fei title: In vitro anti-hepatitis B and SARS virus activities of a titanium-substituted-heteropolytungstate date: 2011-11-23 words: 4748 flesch: 53 summary: HBsAg HBV DNA clear, we have deduced that compound 1 might block the secretion of HBV containing nucleocapsids or destabilize HBV DNA-containing nucleocapsids. The compound 1, evaluated in HepG 2.2.15 cells expressing permanently HBV, significantly reduced the levels of HBV antigens and HBV DNA in a dose-dependent and time-dependent manner. keywords: activities; activity; adv; anti; antiviral; assay; atoms; cccdna; cells; china; compound; concentration; control; coordination; corresponding; cytotoxicity; day; dependent; determined; different; dmem; dna; drug; effective; fig; group; hbsag; hbv; hepatitis; hepg; inhibition; intracellular; kit; levels; manner; mechanism; medium; mtt; negative; non; pcr; pgrna; polyoxoanion; polyoxometalates; poms; prepared; protein; pti; results; reverse; rna; sars; structure; time; treatment; vero; virus; viruses; vitro cache: cord-312965-5hcb15xc.txt plain text: cord-312965-5hcb15xc.txt item: #60 of 79 id: cord-313627-g1iqhsdk author: Zou, Xiaojing title: Characteristics of liver function in patients with SARS-CoV-2 and chronic HBV co-infection date: 2020-06-15 words: 1805 flesch: 50 summary: 14 (13.33%) patients developed liver injury. The proportion of severe COVID-19 was higher in patients with liver injury (P= 0.042). keywords: aclf; acute; admission; alt; ast; characteristics; chronic; cov-2; covid-19; disease; function; hbv; higher; infection; injury; liver; patients; prognosis; sars; severe; study; uln cache: cord-313627-g1iqhsdk.txt plain text: cord-313627-g1iqhsdk.txt item: #61 of 79 id: cord-318143-s4q059g8 author: Cheng, Zhikui title: Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines date: 2015-10-16 words: 5882 flesch: 51 summary: The fact that Na 2 SeO 3 repressed HBV protein synthesis and transcription in a dose-dependent and time-dependent manner prompted us to investigate whether it also influenced HBV DNA levels. A previous study also reported that 30 nM ETV was sufficient to reduce HBV DNA level by 90% keywords: activity; antigen; assay; blot; calcium; cells; concentration; control; core; day; days; decrease; dependent; different; dna; dose; drugs; effect; encapsidated; entecavir; et al; etv; expression; fig; genome; hbeag; hbv; hbv dna; hbx; hepatitis; hepg2.2.15; host; huh-7; human; infected; infection; inhibition; lamivudine; level; manner; mock; models; na(2)seo(3; nassal; northern; nucleoside; observed; obvious; p53; plasmid; protein; qpcr; reduced; replication; result; rna; samples; sec; selenite; selenium; seo; significant; study; suppression; synthesis; time; transcription; treatment; viral; virus cache: cord-318143-s4q059g8.txt plain text: cord-318143-s4q059g8.txt item: #62 of 79 id: cord-318570-wj7r6953 author: Xiao, Yinzong title: Point-of-Care Tests for Hepatitis B: An Overview date: 2020-10-02 words: 8334 flesch: 33 summary: Am Evaluation of a New Hepatitis B Virus Surface Antigen Rapid Test with Improved Sensitivity Evaluation of the performance of four rapid tests for detection of hepatitis B surface antigen in Antananarivo, Madagascar Hepatitis B Surface Antigen Seroprevalence among Prevaccine and Vaccine Era Children in Bangladesh Evaluation of Four Rapid Tests for Detection of Hepatitis B Surface Antigen in Ivory Coast Prevalence of infection with hepatitis B and C virus and coinfection with HIV in medical inpatients in Malawi Detection of Highly Prevalent Hepatitis B Virus Coinfection among HIV-Seropositive Persons in Ghana Reliability of rapid testing for hepatitis B in a region of high HIV endemicity Viral Hepatitis and Rapid Diagnostic Test Based Screening for HBsAg in HIV-infected Patients in Rural Tanzania Prevalence and associations with hepatitis B and hepatitis C infection among HIV-infected adults in South Africa Field performance of the Determine HBsAg point-of-care test for diagnosis of hepatitis B virus co-infection among HIV patients in Zambia Occult hepatitis B and HIV infection HIV-hepatitis B virus coinfection Prevalence of chronic hepatitis B virus infection before and after implementation of a hepatitis B vaccination program among children in Nepal Point of care and oral fluid hepatitis B testing in remote Indigenous communities of northern Australia Evaluation of the analytical performance of six rapid diagnostic tests for the detection of viral hepatitis B and C in Lubumbashi, Democratic Republic of Congo Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients Evaluating HBsAg rapid test performance for different biological samples from low and high infection rate settings & populations Hepatitis B virus sero-prevalence amongst pregnant women in the Gambia Seroprevalence of HBV among people living with HIV in Anyigba Assessment of hepatitis B immunization programme among school students in Qatar Seroprevalence of hepatitis B virus infection and associated factors among healthcare workers in northern Tanzania Seroprevalence of hepatitis B and C virus infections among diabetic patients in Kisangani (North-eastern Democratic Republic of Congo) Eligibility for hepatitis B antiviral therapy among adults in the general population in Zambia Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study The prevalence of hepatitis B virus among HIV-positive patients at Kilimanjaro Christian Medical Centre Referral Hospital Sero-prevalence of HBV and associated risk factors among HIV positive individuals attending ART clinic at Mekelle hospital Hepatitis B Infection, Viral Load and Resistance in HIV-Infected Patients in Mozambique and Zambia palliduminfections among blood donors and Transfusion-related complications among recipients at the Laquintinie hospital in Douala Prevalence of hepatitis B and hepatitis C infection from a population-based study in Southern India Prevalence estimates of HIV, syphilis, hepatitis B and C among female sex workers (FSW) in Brazil Simultaneous Human Immunodeficiency Virus-Hepatitis B-Hepatitis C Point-of-Care Tests Improve Outcomes in Linkage-to-Care: Results of a Randomized Control Trial in Persons Without Healthcare Coverage. Potential Application in Young Children and Infants Evaluation of the Performance of Two Rapid Immunochromatographic Tests for Detection of Hepatitis B Surface Antigen and Anti HCV Antibodies Using Elisa Tested Samples Sensitivity and specificity of commercially available rapid diagnostic tests for viral hepatitis B and C screening in serum samples Evaluation of performance testing of different rapid diagnostic kits in comparison with EIAs to validate detection of hepatitis B virus among high risk group in Nigeria Multi-Disease Diagnostics Landscape for Integrated Management of HIV, HCV, TB and Other Coinfections Analytical performances of simultaneous detection of HIV-1, HIV-2 and hepatitis Cspecific antibodies and hepatitis B surface antigen (HBsAg) by multiplex immunochromatographic rapid test with serum samples: A cross-sectional study Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes Comparative Performance of Three Rapid HBsAg Assays for Detection of HBs Diagnostic Escape Mutants in Clinical Samples: TABLE 1 Point-of-care screening for hepatitis B virus infection in pregnant women at an antenatal clinic: A South African experience A guide to aid the selection of diagnostic tests Evaluation of Rapid Diagnostic Tests for Assessment of Hepatitis B in Resource-Limited Settings Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: Implications for field studies Performance of rapid diagnostic tests for the detection of anti-HBs in various patient populations Performance of the Xpert HBV Viral Load assay versus the Aptima Quant assay for quantifying hepatitis B virus DNA Evaluation of the Xpert HBV Viral Load for hepatitis B virus molecular testing Rapid, random-access, quantification of hepatitis B virus using the Cepheid Xpert®HBV Viral Load assay Prevention of materno-foetal transmission of hepatitis B in sub-Saharan Africa: keywords: access; accuracy; africa; analysis; antigen; approach; assay; assessment; available; b virus; barriers; blood; care; cascade; chronic; clinical; community; cost; countries; current; data; dbs; detection; determine; diagnostic; different; disease; dna; effectiveness; eligibility; elimination; estimates; evaluation; expensive; factors; fibrosis; field; figure; general; hbsag; hbv; hcv; health; healthcare; hepatitis; high; hiv; income; infected; infection; key; laboratory; level; limited; linkage; liver; load; long; low; management; meta; molecular; monitoring; multiplex; need; new; novel; patients; people; performance; pocs; point; populations; positive; potential; practice; prevalence; process; programs; public; quality; rapid; regulatory; related; reported; resource; results; review; risk; samples; screening; sensitivity; serum; services; settings; specificity; stage; standard; step; studies; study; surface; testing; tests; time; treatment; use; vaccination; viral; virus; world; xpert cache: cord-318570-wj7r6953.txt plain text: cord-318570-wj7r6953.txt item: #63 of 79 id: cord-318853-mxyxwkhx author: Sallie, Richard title: Replicative homeostasis II: Influence of polymerase fidelity on RNA virus quasispecies biology: Implications for immune recognition, viral autoimmunity and other "virus receptor" diseases date: 2005-08-22 words: 10548 flesch: 17 summary: Of necessity, some receptor affinity studies have used cloned viral protein ligands, an artificial situation that cannot approach the phenotypic complexity of RNA viral protein quasispecies. Viral receptor disease is a unifying hypothesis that may also explain some diseases with well-established, but multi-factorial and apparently unrelated aetiologies – like coronary artery and other vascular diseases – in addition to diseases like schizophrenia that are poorly understood and lack plausible, coherent, pathogenic explanations. keywords: active; acute; adaptive; affinity; analysis; antibodies; antigenic; associated; association; autoimmune; autoimmunity; binding; blood; brain; broad; c virus; cause; cell; cellular; chronic; clearance; clinical; common; complex; concentrations; consensus; control; corresponding; dementia; detection; development; diabetes; disease; distribution; diversity; dna; early; eerna; effect; endothelial; entry; envelope; envelope proteins; epidemic; equilibrium; escape; evidence; evolutionary; expression; factor; fidelity; figure; following; frequency; function; gene; genetic; genomic; geq; hbv; hcv; hepatitis; high; hiv; homeostasis; hormone; host; human; hypertension; immune; immune responses; immunological; important; infection; inflammatory; influenza; insulin; interactions; kinetics; lack; leptin; level; like; liver; long; low; major; maternal; mechanism; mellitus; molecules; mutations; non; normal; obesity; particular; patients; pcr; phenotypic; pol; pol fidelity; polymerase; polymorphism; population; possible; primary; processivity; progressive; properties; proteins; quasispecies; receptor; recognition; related; relationship; replication; resistance; responses; results; risk; rna; rna pol; rna quasispecies; rna virus; rnas; schizophrenia; self; sequence; serum; similar; specific; spectrum; surface; survival; synthesis; system; threshold; tissue; translation; type; variable; variant; variant viral; variations; vascular; viraemia; viral; viral envelope; viral proteins; viral quasispecies; viral replication; viral rna; virus; virus infection; viruses; weeks; wild; ~10 cache: cord-318853-mxyxwkhx.txt plain text: cord-318853-mxyxwkhx.txt item: #64 of 79 id: cord-320106-thre6r63 author: Xu, Zhihui title: Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure date: 2010-09-17 words: 4435 flesch: 40 summary: No significant correlation exists between core promoter mutations, viral replication and liver damage in chronic hepatitis B infection Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis Chinese Society of Infectious Diseases and Parasitology; and Chinese Society of Hepatology. key: cord-320106-thre6r63 authors: Xu, Zhihui; Ren, Xiaoqiang; Liu, Yan; Li, Xiaodong; Bai, Siyu; Zhong, Yanwei; Wang, Lin; Mao, Panyong; Wang, Huifen; Xin, Shaojie; Wong, Vincent Wai-Sun; Chan, Henry Lik-Yuen; Zoulim, Fabien; Xu, Dongping title: Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure date: 2010-09-17 journal: J Gastroenterol DOI: 10.1007/s00535-010-0315-4 sha: doc_id: 320106 cord_uid: thre6r63 OBJECTIVE: To investigate the features of hepatitis B virus (HBV) basal core promoter/precore (BCP/PC) mutations and genotypes in a large number of mild/severe chronic hepatitis B (CHB-M/CHB-S), and acute-on-chronic liver failure (ACLF) patients and analyze the clinical implications of the virologic features. keywords: aclf; aclf patients; acute; alt; analysis; association; b virus; basal; bcp; chb; china; chinese; chronic; clinical; core; criteria; detection; development; different; disease; dna; failure; features; fulminant; g1764a; g1896a; genotypes; groups; hbeag; hbv; hepatitis; higher; hospital; illness; immune; infection; liver; mutants; mutations; number; outcome; patients; pcr; precore; promoter; regions; replication; sequences; severe; severity; significant; sites; study; t1768a; table; viral; virologic; virus; wild cache: cord-320106-thre6r63.txt plain text: cord-320106-thre6r63.txt item: #65 of 79 id: cord-321481-vrfwczve author: Watashi, Koichi title: NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry date: 2014-02-19 words: 4944 flesch: 33 summary: Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity Optimal management of chronic hepatitis B patients with treatment failure and antiviral drug resistance Hepatitis B: Reflections on the current approach to antiviral therapy Hepatitis B surface antigen levels: Association with 5-year response to peginterferon alfa-2a in hepatitis B e-antigen-negative patients IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome Entry inhibitors and their use in the treatment of HIV-1 infection Gulping rather than sipping: Macropinocytosis as a way of virus entry Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral therapies Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus Myristoylated PreS1-domain of the hepatitis B virus L-protein mediates specific binding to differentiated hepatocytes Viral and cellular determinants involved in hepadnaviral entry Proteoglycans act as cellular hepatitis delta virus attachment receptors Role of glycosaminoglycans for binding and infection of hepatitis B virus Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans Clathrin-mediated endocytosis and lysosomal cleavage of hepatitis B virus capsid-like core particles Hepatitis B virus may enter HepG2 cells complemented with human NTCP via macropinocytosis Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis Hepatitis B virus requires intact caveolin-1 function for productive infection in HepaRG cells Structural relationships between minor and major proteins of hepatitis B surface antigen Large surface proteins of hepatitis B virus containing the pre-S sequence Entry of hepatitis B and C viruses-Recent progress and future impact Entry of hepatitis delta virus requires the conserved cysteine residues of the hepatitis B virus envelope protein antigenic loop and is blocked by inhibitors of thiol-disulfide exchange N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus Neutralization of hepatitis B virus infectivity by a murine monoclonal antibody: An experimental study in the chimpanzee The pre-s2 domain of the hepatitis B virus is dispensable for infectivity but serves a spacer function for L-protein-connected virus assembly A function essential to viral entry underlies the hepatitis B virus a determinant Structural characterization of viral neutralizing monoclonal antibodies to hepatitis B surface antigen Mapping of the hepatitis B virus pre-S1 domain involved in receptor recognition Characterization of a hepatitis B and hepatitis delta virus receptor binding site Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein In vivo neutralization of hepatitis B virus infection by an anti-preS1 humanized antibody in chimpanzees Infection process of the hepatitis B virus depends on the presence of a defined sequence in the pre-S1 domain Fine mapping of virus-neutralizing epitopes on hepatitis B virus PreS1 Fine mapping of pre-S sequence requirements for hepatitis B virus large envelope protein-mediated receptor interaction Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes Expression and transport function of drug uptake transporters in differentiated HepaRG cells Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter NTCP Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide Cyclosporin A modulates the sensitivity of HIV-1 to host restriction factors Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication Alisporivir, a cyclosporin derivative that selectively inhibits cyclophilin, for the treatment of HCV infection Cyclophilin inhibitors for hepatitis C therapy Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP) keywords: able; acid; activity; additional; agents; analogs; analysis; anti; antiviral; asbt; attachment; b virus; bile; binding; cells; cellular; clinical; csa; culture; cyclophilin; dependent; development; different; domain; drug; early; efficient; entry; envelope; factors; function; hbv; hbv infection; hdv; heparg; hepatitis; hepatocytes; hepg2; host; human; identification; infection; inhibition; inhibitors; lhbs; liver; mechanisms; membrane; model; molecular; mouse; new; non; ntcp; polypeptide; pres1; primary; process; protein; receptor; region; replication; salt; sodium; specific; step; support; surface; susceptibility; target; targeting; taurocholate; transporter; tupaia; viral; virus; viruses cache: cord-321481-vrfwczve.txt plain text: cord-321481-vrfwczve.txt item: #66 of 79 id: cord-324984-ojrpsdt9 author: Ji, Xingyue title: Medicinal chemistry strategies toward host targeting antiviral agents date: 2020-02-14 words: 16870 flesch: 33 summary: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus Molecular chaperone Hsp90 is a therapeutic target for noroviruses Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers Hsp90, an unlikely ally in the war on cancer Geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro Inhibition of heat-shock protein 90 reduces Ebola virus replication Heat shock protein 90 controls HIV-1 reactivation from latency Hsp90 inhibitors reduce influenza virus replication in cell culture Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance A novel class of geldanamycin derivatives as HCV replication inhibitors targeting on Hsp90: synthesis, structure-activity relationships and anti-HCV activity in GS4.3 replicon cells Synthesis and biological evaluation of heat-shock protein 90 inhibitors: geldanamycin derivatives with broad antiviral activities Hsp90 inhibitor AT-533 blocks HSV-1 nuclear egress and assembly Inhibition of heat-shock protein 90 reduces Ebola virus replication Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro Hsp90 molecular chaperone inhibitors: are we there yet? but not in patients in a randomized clinical trial Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90 Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits Geldanamycin, a potent and specific inhibitor of Hsp90, inhibits gene expression and replication of human cytomegalovirus Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: keywords: acid; active; activities; activity; addition; adverse; agents; analogues; antagonist; antiviral; antiviral activity; antiviral agents; apobec3; assembly; associated; barrier; binding; bioavailability; block; broad; c virus; cancer; ccr5; cells; cellular; chaperone; chemical; chemokine; chronic; class; clinical; combination; complex; compound; concentration; csa; csgalnact-1; cxcr4; cyclophilin; cyps; daas; data; degradation; dengue; denv; derivatives; design; development; dgat-1; different; direct; discovered; dna; dosage; drug; ebov; effects; efficacy; entry; enzyme; erα; essential; example; expression; factor; fda; figure; folding; functions; gak; genetic; genotype; glucosidase; group; hbv; hcv; hcv activity; hcv replication; heat; hepatitis; high; hiv-1; host; hsc70; hsp90; htas; human; identification; ifn; immunodeficiency; impdh; improved; infected; infections; influenza; inhibited; inhibition; inhibitors; interaction; interferon; intracellular; involved; kinase; kinase inhibitors; lead; level; life; low; major; mechanism; mice; micromolar; modifications; molecular; molecule; multiple; new; nitazoxanide; novel; ntcp; observed; optimization; oral; pathways; patients; phase; polymerase; polypeptide; potent; potent antiviral; potential; profiles; promising; protein; range; rbv; receptor; replication; resistance; response; restriction; results; ribavirin; rna; roles; safety; selective; series; severe; shock; significant; site; small; specific; spectrum; spectrum antiviral; strategy; structure; studies; study; synthesis; targeting; targets; therapy; toxicity; treatment; trial; tropic; tropism; type; values; vif; viral infections; viral proteins; virus; virus replication; viruses; vitro; vivo; wide cache: cord-324984-ojrpsdt9.txt plain text: cord-324984-ojrpsdt9.txt item: #67 of 79 id: cord-325280-4whzcmqv author: Takizawa, Naoki title: Current landscape and future prospects of antiviral drugs derived from microbial products date: 2017-10-11 words: 6633 flesch: 28 summary: In addition, the current state of development of antiviral drugs that target influenza virus and hepatitis B virus, and the future prospects for antivirals from natural products are described and discussed. Approximately 90 drugs have been approved to treat human infectious diseases caused by the following nine viruses: HIV, human cytomegalovirus, hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus, influenza virus, respiratory syncytial virus, varicella zoster virus and human papillomavirus. keywords: acid; active; activities; activity; agents; amantadine; analogs; antigens; antiviral; antiviral drugs; b virus; binding; broad; cccdna; cells; cellular; circular; class; clinical; complex; compounds; csa; derivative; development; diseases; dna; drugs; ebola; effective; effects; entry; exhibit; figure; form; future; genome; h1n1; hbv; hcv; health; hepatitis; hiv; host; human; imc; immunodeficiency; infected; infections; influenza; influenza virus; inhibition; inhibitors; key; mechanism; membrane; metabolites; microbial; model; mrna; natural; neuraminidase; new; novel; nucleos(t)ide; nucleoside; pb2; polymerase; polypeptide; potential; products; promising; propagation; protein; replication; respiratory; review; ribavirin; rna; rnase; screening; sialic; sialidase; siastatin; sodium; specific; spectrum; structure; surface; synthesis; t-705; target; taurocholate; therapeutic; treatment; trials; vaccines; virus; viruses; zanamivir cache: cord-325280-4whzcmqv.txt plain text: cord-325280-4whzcmqv.txt item: #68 of 79 id: cord-331289-02411gfv author: Di Minno, Giovanni title: Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders() date: 2015-07-20 words: 8176 flesch: 34 summary: receiver operating characteristic analysis Placental transmission of human parvovirus 4 in newborns with hydrops Serodiagnosis of primary infections with human parvovirus 4, Finland Human parvovirus 4 infection Human parvovirus 4 viremia in young children Novel parvovirus and related variant in human plasma Detection of a novel DNA virus (TTV) in blood donors and blood products Validation of SYBR Green based quantification assay for the detection of human Torque Teno virus titers from plasma West Nile Virus: Detection with Serologic and Real-time PCR Assays Diagnosis of west nile virus human infections: overview and proposal of diagnostic protocols considering the results of external quality assessment studies Second international diagnostic accuracy study for the serological detection of West Nile virus infection Global incidence and prevalence of selected curable sexually transmitted infections Use of PCR in the diagnosis of early syphilis in the United Kingdom Evaluation of a PCR test for detection of treponema pallidum in swabs and blood The laboratory diagnosis of syphilis Current advances in detection and treatment of babesiosis A new real-time PCR assay for improved detection of the parasite Babesia microti Multiplex assay detection of immunoglobulin G antibodies that recognize Babesia microti antigens World Health Organisation (WHO) Guidelines on viral inactivation and removal procedures intended to assure the viral safety of human blood plasma products keywords: acid; acute; agents; amplification; antibodies; antibody; antigen; approach; assays; b19; bleeding; blood; blood donors; cases; chikungunya; clinical; clotting; concentrates; concern; countries; current; detection; development; diagnosis; disease; disorders; dna; donations; donors; effective; european; evaluation; factor; fees; general; global; grants; haemophilia; hbc; hbv; hcv; health; hepatitis; hev; higher; hiv; hiv-1; human; immunodeficiency; inactivation; incidence; individuals; infection; level; low; methods; nat; new; nile; novel; nucleic; number; pallidum; parvovirus; pathogen; patients; pcr; period; personal; pfizer; plasma; population; positive; potential; presence; prevalence; prions; procedures; products; real; recent; recombinant; recombinant products; residual; results; risk; rna; safety; samples; screening; selection; sensitivity; serological; severe; specific; specificity; study; supply; technology; testing; tests; time; transfusion; transmission; treatment; type; use; variant; viii; viral; virus; viruses; west; wnv; world cache: cord-331289-02411gfv.txt plain text: cord-331289-02411gfv.txt item: #69 of 79 id: cord-331731-c2r0kfaz author: Anugwom, Chimaobi M title: Inverse association between chronic hepatitis B infection and COVID-19: immune-exhaustion or coincidence? date: 2020-06-05 words: 712 flesch: 39 summary: In this regard, research has documented that, chronic HBV infection leads to a reduced or absent virus specific T-cell reactivity (although HBV-specific T cells). We evaluated all peer-reviewed articles, written in the English language, reporting cases of COVID-19 infection and specifically defining rates of HBV infection and hospital admission, since December 1 st , 2019 until March 25 th , 2020 and found a surprisingly low prevalence of chronic HBV in COVID-19 cases admitted to the hospital. keywords: chronic; clinical; covid-19; hbv; hcv; hepatitis; immune; infection; virus cache: cord-331731-c2r0kfaz.txt plain text: cord-331731-c2r0kfaz.txt item: #70 of 79 id: cord-333220-tcvs4beg author: Lee, Szu-Yuan title: Compact optical diagnostic device for isothermal nucleic acids amplification date: 2008-08-12 words: 4854 flesch: 44 summary: This system can provide appropriate reaction conditions for HBV LAMP DNA amplification. After the performance of micro-reactor system is confirmed, HBV LAMP reactions can be transplanted into this system. keywords: addition; amplification; apparatus; applications; base; buffer; changes; conditions; copies; design; detection; device; disposable; dna; fig; gene; hbv; hbv dna; hbv lamp; hepatitis; inhibitors; integrated; intensity; isothermal; isothermal amplification; lamp; lamp reaction; level; light; loop; magnesium; method; micro; min; monitoring; optical; pcr; pmma; polymerase; primers; product; pyrophosphate; rapid; reaction; reactor; real; results; sequences; serum; specimens; study; system; temperature; template; time; total; turbidity; unit; usa; viral; virus cache: cord-333220-tcvs4beg.txt plain text: cord-333220-tcvs4beg.txt item: #71 of 79 id: cord-334150-t6n95laz author: PENG, LIANG title: Serum proteomics analysis and comparisons using iTRAQ in the progression of hepatitis B date: 2013-09-18 words: 3197 flesch: 35 summary: key: cord-334150-t6n95laz authors: PENG, LIANG; LIU, JING; LI, YANG-MEI; HUANG, ZHAN-LIAN; WANG, PEI-PEI; GU, YU-RONG; ZHENG, YU-BAO; GAO, ZHI-LIANG title: Serum proteomics analysis and comparisons using iTRAQ in the progression of hepatitis B date: 2013-09-18 journal: Exp Ther Med DOI: 10.3892/etm.2013.1310 sha: doc_id: 334150 cord_uid: t6n95laz The aim of this study was to analyze the changes in serum protein levels in the progression of hepatitis B using isobaric tags for relative and absolute quantitation (iTRAQ) analysis, in addition to comparing the serum protein levels of patients with chronic hepatitis B (CHB), patients with hepatitis B virus-induced acute-on-chronic liver failure (HBV-induced ACLF) and normal individuals. The purpose of this study was to analyze serum protein levels using iTRAQ in normal controls, as well as patients with chronic hepatitis B (CHB) and HBV-induced ACLF, and to verify those results using western blotting. keywords: aclf; acute; analysis; apolipoprotein; biological; biomarker; blotting; buffer; changes; chb; chronic; cirrhosis; controls; crp; differences; diseases; expression; factor; failure; fibrosis; hbv; healthy; hepatic; hepatitis; itraq; levels; liver; mass; min; patients; plasma; platelet; precursor; present; progression; protein; proteomics; results; samples; serum; significant; studies; study; usa; vitronectin; western cache: cord-334150-t6n95laz.txt plain text: cord-334150-t6n95laz.txt item: #72 of 79 id: cord-340503-zwdewiu1 author: Mokhtarzadeh, Ahad title: Nanomaterial-based biosensors for detection of pathogenic virus date: 2017-10-13 words: 7717 flesch: 35 summary: Table 1 offers a comparison of advantages and limitations of some of the most commonly used methods for virus detection. Nowadays, nanotechnology is focused on the elimination of disadvantages of existing methods for virus detection to minimize costs and time consuming. keywords: activity; advantages; alumina; antibodies; applications; area; assay; aunps; base; biological; biosensing; biosensor; capture; carbon; copper; cost; detection; diagnosis; different; diseases; dna; dots; easy; effect; effective; electrochemical; electrode; energy; et al; field; fig; fluorescence; free; gene; gold; good; graphene; great; h5n1; hbv; hepatitis; high; hiv; human; hybridization; imaging; immobilization; immobilized; immunosensor; influenza; label; light; limit; linear; lod; magnetic; method; modified; molecules; nanocomposite; nanomaterials; nanoparticles; nanoporous; nanotechnology; nanotubes; new; novel; oligonucleotide; optical; order; oxide; pathogenic; platform; probe; properties; protein; qds; quantum; range; rapid; research; resonance; samples; selective; selectivity; sensitive; sensitivity; sensors; serum; signal; silica; single; size; small; specific; specificity; structure; surface; system; target; time; treatment; unique; viral; virus; virus detection; viruses; way; wide; zno cache: cord-340503-zwdewiu1.txt plain text: cord-340503-zwdewiu1.txt item: #73 of 79 id: cord-344084-z4t2wkgk author: Ellwanger, Joel Henrique title: Beyond HIV infection: neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases date: 2020-05-30 words: 15779 flesch: 32 summary: Besides, the regulation of multiple aspects of the immune system is strongly influenced by EVs (O'Neill and Quah, 2008; Colombo et al., 2014; Ellwanger et al., 2016) . This knowledge gap should be addressed in further studies since the reemergence of ROCV in Brazil is a concern in terms of public health (Figueiredo, 2007; Ellwanger et al., 2017b) . keywords: absence; action; acute; allele; analysis; antagonists; antibodies; articles; aspects; association; authors; blood; brain; brazilian; cancer; cardiomyopathy; cases; cause; cchfv; ccr5; ccr5 antagonists; ccr5 expression; ccr5 gene; ccr5δ32; cd4; cells; cervical; chemokine; chemokine receptor; chronic; clearance; clinical; cmv; cns; conditions; congo; context; controls; coronavirus; countries; crimean; cxcr4; cytokines; cytomegalovirus; data; deficiency; dengue; denv; denv infection; dependent; development; different; disease; editing; effects; ellwanger et; encephalitis; endemic; et al; evaluated; evidence; evs; example; exosomes; expression; extracellular; factor; family; fever; findings; flaviviruses; following; frequency; gene; genetic; genotype; glass; global; hbv; hcv; hemorrhagic; hepatitis; high; hiv; hiv infection; homozygous; host; hpv; human; ifn; immune; impact; important; individuals; infected; infection; infection ccr5; inflammation; inflammatory; influence; influenza; influenza infection; interaction; interferon; involvement; japanese; jev; lesions; lim; lim et; liver; manifestations; maraviroc; mechanisms; mice; migration; model; molecules; mortality; mouse; multiple; mutation; natural; neuroinvasive; nile; non; note; outcome; pathogenesis; patients; polymorphism; population; possible; potential; progression; protective; protein; rate; recent; receptor; receptor ccr5; reduced; regulated; regulation; replication; research; respiratory; response; results; review; rhinovirus; risk; rna; rocv; role; sars; sense; severe; severity; significant; single; soluble; specific; studies; study; surface; susceptibility; symptomatic; system; table; therapy; transmission; treatment; types; use; variant; venuti et; viral; virus; virus infection; viruses; west; wild; wnv; wnv infection; zhang et cache: cord-344084-z4t2wkgk.txt plain text: cord-344084-z4t2wkgk.txt item: #74 of 79 id: cord-347710-ff64y6ef author: Wan, Qianya title: Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development date: 2020-07-13 words: 36727 flesch: 38 summary: First, Hsp90 works as a classic chaperone protein to stabilize virus proteins. 57, 473 Except for promoting viral protein translation by binding with the viral IRES sequence, hnRNPs can directly bind with virus proteins to facilitate virus replication. keywords: a71; able; acting; activation; active; activities; activity; acute; addition; adenovirus; affinity; alpha; alternative; analysis; antibodies; antigen; antiviral; apoptosis; apoptotic; assembly; association; atp; atpase; attachment; barr; barr virus; binding; block; c virus; cancer; cancer cells; capsid; capsid protein; carcinoma; case; causes; cdc37; cells; cellular; certain; chaperone; cleavage; client; cochaperones; complex; complex formation; complexes; conditions; conformation; conserved; control; core; core protein; coronavirus; coxsackievirus; critical; crucial; cycle; cytomegalovirus; cytoplasm; cytosol; death; degradation; dendritic; dengue; dengue virus; denv; dependent; development; different; differentiation; direct; diseases; disruption; disulfide; dna; dna replication; dnaj; domain; downstream; drug; e2f; early; ebv; effects; efficient; eif2α; element; elevated; encephalitis; encephalitis virus; endoplasmic; enterovirus; entry; envelope; envelope protein; epstein; erp57; essential; eukaryotic; evidence; example; exhibits; exon; export; expression; facilitate; factor; family; family proteins; fig; flavivirus; folding; formation; forms; free; function; gene; gene expression; genome; groel; group; growth; grp78; hbv; hbx; hcv; hcv rna; hdj1; heat; heat shock; help; hepatitis; herpes; herpesvirus; heterogeneous; high; hiv-1; hnrnp; hnrnp a1; hnrnp c; hnrnp k; host; host cells; hpv; hsc70; hsp27; hsp60s; hsp70 family; hsp72; hsp90; hsp90 inhibitors; hsps; hsv; human; hydrolysis; identification; immune; immunity; immunodeficiency; immunodeficiency virus; implications; import; important; increase; induced; induction; infected; infection; inflammation; inflammatory; influenza; influenza virus; inhibition; inhibitors; initiation; innate; interaction; interferon; internal; intracellular; ire1; ires; isoform; isomerase; japanese; jev; kda; key; kinase; knockdown; large; late; leads; level; life; like; lipid; liver; localization; long; low; machinery; major; mammalian; manner; maturation; mechanism; members; membrane; mitochondrial; modulates; modulation; molecular; molecules; mrna; multiple; n protein; natural; nef; negative; new; non; novel; ns1; ns5a; nuclear; nucleocapsid; nucleus; number; overexpression; oxidative; p53; p58ipk; papillomavirus; pathogenesis; pathway; patients; pb2; pdi; peptide; perk; phosphorylation; pim1; pkr; pocket; poliovirus; polyadenylation; polymerase; polyomavirus; polypyrimidine; positive; post; potential; prb; present; process; production; products; promoter; proper; properties; proteasome; protein; protein complex; protein disulfide; protein expression; protein folding; protein hnrnp; protein kinase; protein response; protein synthesis; protein translation; ptb; quercetin; receptor; recognition; region; regulation; regulatory; release; replication complex; residues; resistance; respiratory; response; responsible; results; reticulum; retrovirus; ribonucleoprotein; rna; rna chaperones; rna genome; rna polymerase; rna replication; rna splicing; role; ros; rotavirus; rsv; sarcoma; sars; sequence; shock protein; signaling; silencer; simian; similar; simplex; simplex virus; single; site; small; species; specific; splice; splicing; stability; stage; step; stress; stress proteins; structure; studies; study; substrate; suppresses; surface; survival; sv40; synthesis; system; tag; target; terminal; terminus; toll; tract; trafficking; transcription; transformation; translation; transport; tumor; type; unfolded; unfolded protein; upr; upregulated; viral; viral capsid; viral protein; viral rna; virion; virus; virus entry; virus gene; virus hnrnp; virus infection; virus polymerase; virus proteins; virus replication; virus rna; virus type; viruses; vitro; vivo; vp1; vpr; vrc cache: cord-347710-ff64y6ef.txt plain text: cord-347710-ff64y6ef.txt item: #75 of 79 id: cord-350393-j80k2v21 author: Chen, Liping title: Clinical characteristics in patients with SARS‐CoV‐2/HBV co‐infection date: 2020-07-15 words: 1506 flesch: 41 summary: Huang reported SARS patients with HBV infection were more prone to develop higher degree of liver injury and severe hepatitis, however, the data of the prevalence of SARS-CoV-2/HBV co-infection in COVID-19 patients is still absent 9 . Taken into consideration that viral co-infection can exacerbate liver injury thus have a big impact on disease progression and outcome 11, 12 , we investigated the prevalence of HBV infection in COVID-19 patients and found that there was a comparable rate of SARS-CoV-2/HBV co-infection to that of general population (6.1% vs 6%). keywords: abnormal; cases; center; characteristics; china; clinical; coronavirus; cov-2; covid-19; differences; function; hbv; health; hepatitis; hospital; infected; infection; injury; liver; patients; related; sars; study; virus cache: cord-350393-j80k2v21.txt plain text: cord-350393-j80k2v21.txt item: #76 of 79 id: cord-350964-0jtfc271 author: Van Nguyen, Dung title: Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam date: 2018-02-28 words: 4804 flesch: 47 summary: Several factors may contribute to the risk of zoonotic rodent or bat virus transmission. Rodent hepacivirus sequences (360 nucleotides) formed two well supported clades (Figure 2a) . keywords: acid; amino; bamboo; bat; bats; clade; closest; complete; delta; detection; determined; distances; dna; farmed; figure; genome; hbv; hcv; hepacivirus; hepatitis; hev; high; hipposideros; host; human; identity; liver; low; mekong; new; novel; nucleotides; orfs; pcr; pegivirus; prevalence; primers; range; rats; rattus; region; rna; rodent; samples; screening; sequences; similar; species; study; table; transmission; vietnam; vietnamese; viral; viruses; zoonotic cache: cord-350964-0jtfc271.txt plain text: cord-350964-0jtfc271.txt item: #77 of 79 id: cord-351295-4toxlskr author: Lanave, Gianvito title: Identification of hepadnavirus in the sera of cats date: 2019-07-23 words: 2668 flesch: 40 summary: Fisher's exact test was performed to the collection A to evaluate the correlation between DCH positive cats and retrovirus positive cats. The actual patho-biology of DCH in cats should be determined in order to understand better the patterns of DCH infection. keywords: animals; article; australian; blood; cats; clinical; collection; copies; damage; dch; diagnosis; diseases; dna; feline; felv; fig; genome; group; hbv; hepadnavirus; hepatic; hepatitis; human; infected; infection; information; large; license; liver; novel; patients; pcr; phylogenetic; positive; prevalence; sera; significant; strain; study; sydney; test; total; viral; virus; viruses; www.nature.com/scientificreports cache: cord-351295-4toxlskr.txt plain text: cord-351295-4toxlskr.txt item: #78 of 79 id: cord-352988-9ey3ir5e author: Xiang, Yang-fei title: Effects of 1,2,4,6-tetra-O-galloyl-β-D-glucose from P. emblica on HBsAg and HBeAg secretion in HepG2.2.15 cell culture date: 2010-10-08 words: 1175 flesch: 45 summary: The cytotoxicity of 1246TGG on HepG2.2.15 as well as HepG2 cells was determined by observing cytopathic effects, and the effects of 1246TGG on secretion of HBsAg and HBeAg in HepG2.2.15 cells were assayed by enzyme immunoassay. Here, we investigated the anti-HBV activity of 1246TGG by detecting the HBsAg and HBeAg secretion levels in HepG2.2.15 cell culture, a cell line derived by transfection of cloned HBV DNA into human hepatoblastoma cell line HepG2 and used to assay for anti-HBV agents [4] . keywords: 1246tgg; anti; assay; cells; china; chinese; compound; culture; cytopathic; cytotoxicity; day; effects; emblica; galloyl; glucose; hbeag; hbv; hepatitis; hepg2; hepg2.2.15; secretion; treatment; virus cache: cord-352988-9ey3ir5e.txt plain text: cord-352988-9ey3ir5e.txt item: #79 of 79 id: cord-353467-wbtzvm4i author: Lambert, Carsten title: Functional incorporation of green fluorescent protein into hepatitis B virus envelope particles date: 2004-12-05 words: 6333 flesch: 42 summary: Among the three related large L, middle M, and small S envelope proteins, L has been shown to play the key role in receptor recognition and cell attachment (Le Seyec et al., 1999; Neurath et al., 1986) . Because HBV empty envelope particles, built from the S protein, provide a safe antigen delivery system, their use as a carrier for the presentation of various antigens is a long established practice. keywords: absence; addition; analysis; antibodies; antibody; antigen; assembly; attachment; binding; cells; centrifugation; chains; contrast; data; density; detection; dna; domain; envelope; et al; expression; fig; fluorescent; formation; forms; fractions; fusion; genome; gfp; gfp.s; glycosylated; gradient; green; hbsag; hbv; hepatitis; hepatocytes; hepg2; human; incorporation; infection; intracellular; large; mab; membrane; microsomes; mouse; np-40; particles; plasmid; presence; protein; proteinase; receptor; s.yfp; secretion; sha; site; specific; structure; subviral; sucrose; supernatants; surface; tag; terminal; terminus; topology; transmembrane; type; viral; virion; virus; western; wild cache: cord-353467-wbtzvm4i.txt plain text: cord-353467-wbtzvm4i.txt