key: cord-282280-5pggpbrq
authors: Doornekamp, Laura; van Leeuwen, Leanne; van Gorp, Eric; Voeten, Helene; Goeijenbier, Marco
title: Determinants of Vaccination Uptake in Risk Populations: A Comprehensive Literature Review
date: 2020-08-27
journal: Vaccines (Basel)
DOI: 10.3390/vaccines8030480
sha: 
doc_id: 282280
cord_uid: 5pggpbrq

Vaccination uptake has decreased globally in recent years, with a subsequent rise of vaccine-preventable diseases. Travellers, immunocompromised patients (ICP), and healthcare workers (HCW) are groups at increased risk for (severe) infectious diseases due to their behaviour, health, or occupation, respectively. While targeted vaccination guidelines are available, vaccination uptake seems low. In this review, we give a comprehensive overview of determinants—based on the integrated change model—predicting vaccination uptake in these groups. In travellers, low perceived risk of infection and low awareness of vaccination recommendations contributed to low uptake. Additionally, ICP were often unaware of the recommended vaccinations. A physician’s recommendation is strongly correlated with higher uptake. Furthermore, ICP appeared to be mainly concerned about the risks of vaccination and fear of deterioration of their underlying disease. For HCW, perceived risk of (the severity of) infection for themselves and for their patients together with perceived benefits of vaccination contribute most to their vaccination behaviour. As the determinants that affect uptake are numerous and diverse, we argue that future studies and interventions should be based on multifactorial health behaviour models, especially for travellers and ICP as only a limited number of such studies is available yet.

Vaccinations have proven to play a major role in the prevention and control of many infectious diseases. However, in the twenty-first century, vaccination programs face multiple challenges [1] . The first one is the need for fast development of effective and safe vaccines for new (re-)emerging pathogens. The recent SARS-CoV-2 pandemic is an example in which a vaccination is highly desired and may reduce the enormous impact of the current pandemic. The second challenge in the field of vaccinology is the upcoming trend of vaccine hesitancy and declining vaccination uptake.

Vaccine hesitancy is recognised by the World Health Organization (WHO) to be one of the ten threats to global health [2] . Vaccination uptake is declining globally, resulting in a rise in outbreaks of vaccine-preventable diseases (VPD) [3] . For instance, measles cases have increased-up to 300 percentover the past years [4] . Vaccine hesitancy has predominantly received attention in the light of parents rejecting the national immunization programs. However, low vaccination uptake among adult populations also raises concerns [5] . Adults are progressively at risk for infectious diseases because life expectancy increases [6] , the incidence of chronic diseases that require immunosuppressive treatment rises [7] , and international travel expands [8] . Other determinants will play a role in vaccination uptake in adult populations as compared to children.

Adults who are recommended to get vaccinated can be divided into several risk groups. Risk populations in this context are defined as groups of human individuals with an increased risk of acquiring a (severe) infection due to their behaviour, health, or occupation. To get a broad overview of determinants that play a role in the vaccination uptake among risk groups, this review will focus on three distinct risk groups which consult vaccination clinics frequently, namely: "travellers, immunocompromised patients (ICP) and healthcare workers (HCW)".

Travellers comprise a risk population, as at their destinations they can be exposed to infectious diseases they have not encountered before. Traveller vaccination guidelines are available to protect this population. These guidelines do not only differ per destination but are also dependent on the activities the travellers will undertake and the duration of their stay. Additionally, the country of origin is of importance, because of the endemicity of infectious diseases and therefore natural exposure, and national immunization programs. Moreover, travellers who are not properly vaccinated for their trip are not only at risk for getting sick themselves, they can also create a public health concern for communicable diseases, as they could carry an infection back home to a naïve population [9] .

ICP have an increased risk for serious illnesses caused by infectious diseases due to a diminished function of their immune system. The compromised state of their immune system can be induced by either an underlying disease or the treatment of a disease. As a consequence of fast-developing immunosuppressive therapies for e.g., auto-immune diseases and malignancies, ICP are a constantly growing population [7] . Therefore, optimal protection of this vulnerable group is of utmost importance.

HCW are another risk category for acquiring infectious diseases. Their occupation brings them in close contact with patients, that possibly carry an infectious disease. Furthermore, HCW are not only personally at risk, they may also put their-mostly vulnerable-patients at risk when they work while carrying an infection [10] . On top of that, HCW play an important role in providing their (immunocompromised or travelling) patients with information or recommendations regarding vaccinations.

Vaccination uptake varies between risk populations and there may be differences in determinants that play a role in this behaviour. To find general patterns each risk group will be studied separately. However, as travellers, ICP, and HCW are interrelated, we aim to learn from similarities and differences between these groups. If we understand risk populations' motivations and concerns, we might be able to address these either separately or combined by effective interventions. To get a better overview of all determinants that have a possible impact on uptake, we classified these in a model of health behaviour change.

An abundance of behaviour change models are available that describe determinants affecting preventive health behaviour [11] . In 2003, the integrated change (I-Change) model was developed by de Vries et al. [12] . This model is derived from the attitude-social norm-self-efficacy (ASE) model and integrates several other models, among which are the often-used health belief model (HBM) and the theory of planned behaviour (TPB) (Supplementary Table S1 ). According to the I-Change model, vaccination behaviour is shaped by the intention to get vaccinated which is subject to barriers and facilitators. Intention is established by motivation, awareness, information, and predisposing determinants. As this I-Change model comprises a wide variety of determinants that are used by other studies, for example those based on the HBM and ASE model, we use this model as a conceptual framework.

With this comprehensive review, we aim to better understand determinants that play a role in the uptake of vaccinations in travellers, ICP, and HCW and explore similarities and differences in these three groups. Hereby, we aim to create a solid ground for the development of evidence-based interventions to increase vaccination uptake in the populations that need optimal prevention strategies for infectious diseases.

We performed a systematic database search on 19 February 2020. We performed one search for all three risk groups (Supplementary File S1). For each risk groups we combined search terms for vaccination uptake and health behavioural models. We searched the following databases: Embase, Medline, Cinahl, Web of Science Core Collection, ERIC, PsychINFO, and SocINDEX. As determinants of vaccination uptake may vary over time, we limited our search to studies published during the last ten years (between 1 January 2010 and 1 January 2020). We excluded research papers written in another language than English. All records were retrieved into an EndNote database. Duplicates were removed and titles and abstracts were screened (by LD). Thereafter, papers were sorted in the three different groups and full texts articles were reviewed for suitability using inclusion and exclusion criteria (by L.D. and L.v.L.) using EndNote X9.

Studies were included if they met all of the following criteria: (1) at least 75% of the included respondents are either ICP (patients with autoimmune diseases, malignancies, HIV, asplenia and solid organ or stem cell transplantations) or travellers (including travellers visiting friends and relatives (VFR), short-and long-term business travellers) or HCW (including general practitioners (GPs), physicians and nurses working in a hospital); (2) addressing self-reported cognitive determinants that may explain vaccination uptake; and (3) being performed in Western countries (defined as Europe, North America, Australia, and New Zealand).

We excluded studies that focussed on: (1) children; (2) HCW who care for populations other than the ICP defined in our study (e.g., paediatricians, elderly home physicians) or who are not directly involved in the care for this group (e.g., pharmacists, dentists); (3) future healthcare workers (e.g., medicine or nursing students); (4) uptake of the national immunization programme (e.g., HPV vaccination); (5) hypothetical vaccinations (e.g., a HIV vaccine); (6) vaccinations administered in outbreak situations (e.g., H1N1 vaccine, Ebola vaccine); (7) other very specific target groups (e.g., Roma travellers, migrants, pregnant women; and (8) predisposing factors exclusively. We also excluded qualitative studies and non-peer reviewed articles such as conference abstracts.

In case any doubt or disagreement between the two researchers who performed the study selection (by L.D. and L.v.L.) arose, the specific papers were discussed in a plenary session with all co-authors.

The following background characteristics from included studies were extracted: first author and year of publication; study design; enrolment period; enrolment site; sample size; study population; theoretical framework; and targeted outcome variables. Extracted data was collected in Microsoft Excel 2016 and the presence and impact of determinants were rated in separate sheets per study group (by L.D. and L.v.L.). Random samples were taken to check the data extraction and disagreements were discussed plenary with all co-authors. Furthermore, the quality of studies was assessed using the the AXIS tool [13] , which is a screening tool specifically designed for cross-sectional studies, as those in our review, and includes 20 items relevant to this design. Scores 1-9 are rates as low, 10-14 as medium and 15-20 as high.

The I-Change model was used to organize all determinants that could explain vaccination uptake. A simplified version of this model is shown in Figure 1 . The following concepts are used: (1) predisposing factors, including baseline characteristics of studied populations; (2) information factors, including information retrieved via media, social contacts and HCW; (3) awareness, of the infectious agent being present or a vaccine being available; (4) knowledge (either examined or self-evaluated), about the consequences of the infection, or about the efficacy and duration of protection of vaccination; (5a) perceived risk of the infection, which is divided into perceived severity of the disease and perceived susceptibility to get infected; (5b) perceived risk of vaccination, including vaccine-specific considerations such as fear of side-effects and trust in the effectiveness of the vaccine; (6) attitude, defined as a person's disposition to respond favourably or unfavourably to vaccinations [14] , often reflected by a person's general believes about vaccinations; (7) social influence, which can be social norms imposed by family, friends or religion, but also recommendations from a healthcare professional or tour guide; (8) self-efficacy, defined as beliefs in one's own capacity to perform certain behaviour [15] ; (9) intention to behaviour, expressed by people before they perform the behaviour; (10) barriers and facilitators, that withhold individuals from or enable them to certain behaviour, such as time, costs, or accessibility. Vaccines 2020, 8, x FOR PEER REVIEW 5 of 39 Figure 1 . Simplified I-Change model summarizing the studied determinants that could predict vaccination uptake. We used a simplified version of the I-Change model applied to vaccination uptake. Uptake is shaped by the intention to get vaccinated which is subject to barriers and facilitators. Intention is established by motivation (attitude, social influence, and self-efficacy), awareness (awareness, knowledge, and perceived risk) and information and predisposing determinants. Predisposing factors include baseline characteristics of studied populations and influence awareness, motivation and uptake. Information factors include information retrieved via media, social contacts and healthcare workers. Simplified I-Change model summarizing the studied determinants that could predict vaccination uptake. We used a simplified version of the I-Change model applied to vaccination uptake. Uptake is shaped by the intention to get vaccinated which is subject to barriers and facilitators. Intention is established by motivation (attitude, social influence, and self-efficacy), awareness (awareness, knowledge, and perceived risk) and information and predisposing determinants. Predisposing factors include baseline characteristics of studied populations and influence awareness, motivation and uptake. Information factors include information retrieved via media, social contacts and healthcare workers.

The literature search generated 2227 hits ( Figure 2 ). After removing duplicates and excluding articles published before 2010, 1260 articles were available on the topic. These were screened based on title and abstract, resulting in 242 articles that were eligible for full-text assessment. These were divided into the three subgroups (some were included in more than one category): 30 for travellers, 95 for ICP, and 122 for HCW. Finally, 17, 29, and 44 articles were included in the data analysis for the three groups, respectively. The most common reason for exclusion was that no determinants (other than predisposing factors) were reported. Table 1 describes the characteristics and quality of included studies for travellers, ICP, and HCW. Determinants that play a role in vaccination uptake were retrieved from the articles and summarized in Tables 2-4 for travellers, ICP, and HCW respectively. The results of the quality assessment are presented in Supplementary Table S2 . 

The 17 articles that studied determinants of vaccination uptake among travellers comprised 12 cross-sectional surveys, two pre-and post-travel surveys, and three retrospective studies of which one was based on confirmed cases of VPD (Table 1 ). Travellers that were studied originated from the USA (6 studies), Australia (4 studies), Europe (5 studies), or mixed continents (2 studies). Sample sizes ranged from 55 to 27,386 and comprised Hajj pilgrims in three studies, travellers to Africa in two studies and to Asia in two studies. Other studies had broader inclusion criteria. Three studies 

Hajj x x x VFR x x Backpackers x VPD Influenza x x x x x x x Men x x x x x Pneu x x x HAV x x x x x HBV x x x x x x DTP/Tdap x x x x MMR x x x VZV/HZV x x YF x x x JE x x x Rabies x x x Typhoid fever x x x Vaccines in general x x Determinants Predisposing factors Age ↓ = ↓ ↓ ↑ = = = ↑ Gender: male = = = = = = Education level = ↑ ↑ Travel purpose: VFR = ↓ = ↓ Travel purpose: business ↑ ↓ Travel duration = = ↓ = ↓ ↑

Internet ‹ ‹ ‹ ‹ ‹ « TV/radio ‹ Primary HCW (GP) ‹ ‹ ‹ ‹ « ‹ « « Specialist HCW (travel clinic) ‹ ‹ ‹ ‹ ‹ Family/friends ‹ ‹ ‹ ‹ ‹ ‹ Travel organization « ‹

The following symbols are used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association (tested by multivariate analysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association (tested by chi-square, univariate analysis or correlation coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥50% of the population; « (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥50% of the population; ‹ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ (caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥10% of the population. * determinants were studied in relation to intention to be vaccinated instead of vaccination uptake. The following symbols are used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association (tested by multivariate analysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association (tested by chi-square, univariate analysis or correlation coefficient); 

used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association alysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association ariate analysis or correlation coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to of the population; « (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake ; ‹ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ s) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥10% of the population. * determinants were studied (double caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥50% of the population; 

↑ significant positive association (tested by multivariate analysis); ↓ significant negative association ve association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association n coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to le caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥50% of the population; ∧ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ∨ (caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥10% of the population. * determinants were studied in relation to intention to be vaccinated instead of vaccination uptake. x

Internet/social media 

The following symbols are used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association (tested by multivariate analysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association (tested by chi-square, univariate analysis or correlation coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥50% of the population; « (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥50% of the population; ‹ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ (caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥10% of the population. The following symbols are used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association (tested by multivariate analysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association (tested by chi-square, univariate analysis or correlation coefficient); 

used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association alysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association ariate analysis or correlation coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to of the population; « (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake ; ‹ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ s) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥10% of the population. * determinants were studied (double caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥50% of the population; 

↑ significant positive association (tested by multivariate analysis); ↓ significant negative association ve association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association n coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to le caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ d, but determinant was negatively linked to vaccination uptake in ≥10% of the population. * determinants were studied (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥50% of the population; ∧ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ∨ (caret pointing downwards) significance was not tested, but determinant was negativvely linked to vaccination uptake in ≥10% of the population. 

Social media ↓ ↓ TV/Radio ↓ Evidence-based sources ↑ ↑ ↑ ↑ ↑ Collegues ↑

* One scale (MoVac-flu scale) was used for following determinants: knowledge, attitude and self-efficacy. The following symbols are used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association (tested by multivariate analysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association (tested by chi-square, univariate analysis or correlation coefficient); ↓↑ significant association, for one vaccine positive, for the other negative; « (double caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥50% of the population; « (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥50% of the population; ‹ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ (caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination * One scale (MoVac-flu scale) was used for following determinants: knowledge, attitude and self-efficacy. The following symbols are used: x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association (tested by multivariate analysis); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association (tested by chi-square, univariate analysis or correlation coefficient); ↓↑ significant association, for one vaccine positive, for the other negative; 

x applicable; = no significant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association is); ↑ significant positive association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association te analysis or correlation coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to the population; « (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake (double caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥50% of the population; 

‹ nificant difference; ↑ significant positive association (tested by multivariate analysis); ↓ significant negative association ve association (tested by chi-square, univariate analysis or correlation coefficient); ↓ significant negative association n coefficient); « (double caret pointing upwards) significance was not tested, but determinant was positively linked to le caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ‹ (double caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥50% of the population; ∧ (caret pointing upwards) significance was not tested, but determinant was positively linked to vaccination uptake in ≥10% of the population; ∨ (caret pointing downwards) significance was not tested, but determinant was negatively linked to vaccination uptake in ≥10% of the population. pRisk = perceived risk. pRisk of infection (S/P): S = self; P = patient. The following abbreviations are used (in alphabetical order): CD = Crohn's Disease; DTP = diphtheria, tetanus, poliomyelitis; GP = general practitioner; HAV = hepatitis A virus; HBV = hepatitis B virus; HCW = healthcare workers; HIV = human immunodefiency virus; HSCT = hematological stem cell transplantation; HZV = herpes zoster virus; IBD = inflammatory bowel disease; IS = immunosuppressants; JE = Japanese encephalitis; Men = meningococcal disease; MMR = measles, mumps, rubella; Pneu = pneumococcal disease; Tdap = tetanus, diphtheria, acellular pertussis; SOT = solid organ transplantation; VFR = travellers visiting friends and relatives. VZV = varicella zoster virus, YF = yellow fever.

The 17 articles that studied determinants of vaccination uptake among travellers comprised 12 cross-sectional surveys, two pre-and post-travel surveys, and three retrospective studies of which one was based on confirmed cases of VPD (Table 1 ). Travellers that were studied originated from the USA (6 studies), Australia (4 studies), Europe (5 studies), or mixed continents (2 studies). Sample sizes ranged from 55 to 27,386 and comprised Hajj pilgrims in three studies, travellers to Africa in two studies and to Asia in two studies. Other studies had broader inclusion criteria. Three studies used KAP (knowledge-attitude-practices) surveys and one study mentioned a health behavioural model (theory of planned behaviour) as theoretical background for their study.

Ten articles studied baseline characteristics of travellers that could be associated with vaccination uptake ( Table 2 ). The vaccinations that were studied were diverse, most papers discussed vaccinations for influenza (n = 7), hepatitis B virus (HBV) (n = 6), hepatitis A virus (HAV) (n = 5) and meningococcal disease (n = 5). Regarding age, three papers reported that younger people had a higher uptake [18, 20, 24] . However, for influenza vaccination this was the opposite: older travellers were more likely to be vaccinated for seasonal influenza [27, 32] . Gender was not a significant predictor of vaccination uptake in any of the studies. Education level was studied by three papers [18, 27, 31] . Two found this determinant to be positively associated with (intention to) obtaining recommended vaccinations [28, 31] . Seven studies reported travel purpose in relation to vaccination uptake, but the results were diverse. One study concluded vaccination uptake was highest if the reason of travelling was business or backpacking [20] . However, work-related travel was associated with lower uptake in another study (OR = 0.39, (0.17-0.92)) [27] . Travellers visiting friends and relatives (VFR) had a lower uptake in two studies [24, 29] , but two other studies found no association [20, 25] . Six papers studied the relation between travel duration and vaccination uptake. Two studies showed that uptake was significantly lower when people travelled longer [24, 28] , while one found that it was higher (for rabies only) [29] and three studies found no difference [19, 20, 27] .

No clear relationship between information sources and vaccination uptake was reported. However, eight studies reported a role for the GP, of which three said that the GP was very influential [22, 29, 30, 32] .

Of all the cognitive determinants studied, perceived risk of infection was most frequently described in relation to vaccination uptake (n = 10). Only one study found a significant positive relation (OR 1.74 (95% CI 1.14-2.62)) [16] , and another five reported this factor to play a role in the majority of the study population. Although not often tested for significance, "not feeling at risk of the disease" was a common explanation of a lot of travellers for not receiving the recommended vaccinations. Perceived risk of vaccination was sparsely discussed (n = 4).

Social influence, which comprises mostly trust and recommendations of healthcare providers in this selection of studies, was reported in seven papers and was recognised as important by the majority of the study population in four papers.

Attitude was described in six papers, and was not found to be significant in two of them [19, 31] ; reliance on natural immunity was mentioned three times as a reason to reject vaccination [17, 23, 30] . Awareness was also discussed in six papers; although it was not tested for significance, 13-73% mentioned unawareness of the availability of the vaccination (or unawareness of the recommendation of the vaccination) as an important reason for non-uptake [17, 18, [20] [21] [22] 30] .

Five studies reported on knowledge of VPD; two found a significant positive relation between knowledge and vaccination uptake [20, 26] , one found no relation [19] .

Reported barriers could be classified in costs and lack of time. Costs were the most described; however, it played a modest role in explaining non-uptake and differed per vaccination. For instance, for influenza vaccination uptake costs were mentioned to play a role in less than 7% of travellers, while for HBV (12%), Japanese encephalitis (35%) and pneumococcal vaccination (38%) concerns about costs were much higher. In two papers lack of time was given as part of the explanation of non-uptake in more than 10% of the study population [17, 22] . One paper described that 3-24% of travellers require a reminder to complete their vaccination series [22] .

Twenty-nine articles concerning ICP were included. Most of these studies were cross-sectional (n = 23), but four were prospective (with a follow-up moment) and two retrospective ( Table 1) . Studies were performed among European (n = 23), American (n = 3) and Canadian (n = 3) populations. Sixteen studies involved patients with auto-immune diseases, of which four studies focussed completely on patients with inflammatory bowel disease. The vaccination uptake of HIV patients was studied in three papers. Four papers studied populations with solid tumours, six papers studied patients who received haematological stem cell transplantation (HSCT) and three papers investigated patients who received a solid organ transplantation (SOT). Almost all papers addressed the influenza vaccination uptake (n = 25) and many also included the uptake of pneumococcal vaccinations (n = 13). Influenza vaccination rates varied from 6-79% and pneumococcal vaccination rates from 2-54%. Lowest rates were reported in Polish inflammatory bowel disease (IBD) patients [60] and highest in American rheumatic patients [55] . In ICP, health behaviour models were cited slightly more than in the travellers population. Two studies were based on the (HBM) and another three studies used KAP surveys.

Most studies (17 out of 24 that studied age) found a positive association between age and vaccination uptake (Table 3) . Especially for influenza vaccination, older patients tend to be more compliant with vaccination guidelines in the studied year. Only in one study a negative association was found (OR 0.02, 95% CI (0.01-0.57)) [46] . Most studies report that gender and education level are not significant predictors of vaccination uptake in ICP, with a few exceptions. Three studies showed in a multivariate analysis that males had a higher uptake. Two studies showed a negative association between uptake and education level, while one showed a positive association. In five studies, the use of strong immunosuppressive medication was positively associated with vaccination uptake, whereas in two studies the association was negative and in three there was no association. Generally, ICP with comorbidities in their medical history tend to have a higher uptake in four [38, 39, 42, 54] out of seven studies. One study reported a negative association [42] and two found no significant difference [33, 52] . All five papers that included vaccination history (for the same or another vaccination), concluded that there was a positive association between vaccination uptake in the past and current uptake [34, 43, 46, 47, 52] .

Thirteen studies investigated where ICP retrieve their information from. In general, gathering information from online media sources was somewhat associated with a lower vaccination uptake, while receiving information from HCW resulted in a higher uptake [35, 41] .

Perceived risk of vaccination was the most frequently mentioned cognitive determinant, being discussed in 21 of the 29 articles. In all three papers that tested for significance, a negative correlation with vaccination uptake was found, meaning that a higher perceived risk of a vaccine results in a lower uptake. But also that a lower perceived risk, reflected for example by trust in the effectivity of this specific vaccine, increases the uptake. Fear for side-effects or deterioration of their disease caused by the vaccination were mentioned often. Another concern that was often expressed was the doubt of effectivity of vaccination, due to either the immunogenicity of the vaccine or due to the compromised state of the patients' immune system. Distrust was reported more often for influenza than for other vaccinations [55] .

Awareness of either the availability of or the indication for a vaccination was also widely discussed (n = 17). While only found to be significantly correlated twice, this determinant played a role in the majority of the study population in seven papers. Because ICP often mention vaccination not being proposed as a reason for non-uptake, this determinant is related to the information factors, knowledge, and HCW recommendation.

Attitude, covering the attitude to vaccinations in general, was mentioned in 14 studies and was found to be positively correlated twice in multivariate analysis. The effect of a favourable attitude to vaccinations in general was larger on uptake of influenza (adjusted odds ratio (aOR) 3.4 (95% confidence interval (CI) 1.2-9.5)) than on uptake of pneumococcal vaccination (aOR 1.7 [95% CI 0.8-3.5]) [44] . Perceived risk of infection was mentioned equally often as attitude (n = 14) and was also positively associated with uptake, in two of the four studies that tested for significance [46, 59] .

Although knowledge was only addressed in four papers, in two out of the three articles that tested for significance a positive correlation was found. Recommendation of an HCW was studied in 12 out of the 29 papers and a significant correlation was found in all eight papers that performed statistical analysis. In addition, a frequently reported reason for not being vaccinated was that vaccination was not offered or recommended, which we included under awareness.

Self-efficacy was reported in two papers. One reported that more than 10% of unvaccinated ICP were unsure of how to arrange to receive the vaccines [56] , while another reported that patients who find it easier to attend a GP for vaccination, have a higher intention to get vaccinated (p < 0.001) [46] . Regarding intention to behaviour, one high-quality study expressed that 80% of their IBD study population expressed to be willing to receive all of the recommended vaccinations, while only 9% had ever received a pneumococcal vaccination and only 28% was vaccinated against influenza at the time of participation in the study [58] . In another study with 17% influenza and 4% pneumococcal vaccination uptake, the intention to be vaccinated next year was also high and not significantly different between the vaccinated (89%) and unvaccinated group (80%) [59] .

Cost was only mentioned as a barrier in one paper that found a significant negative correlation with uptake [36] . Lack of time (n = 2) and the inconvenience of another appointment (n = 4) were more often given as reasons for declining vaccination.

In HCW, influenza vaccination uptake is most widely studied. In 35 articles out of the 44, seasonal influenza vaccination was the only vaccine studied, with uptake varying between 9% [63] to 97% (mandatory policy) [96] . Most studies were conducted in Italy (n = 8), followed by France (n = 5) and the USA (n = 5). All but one were designed as cross-sectional surveys, with sample sizes ranging from 77 [76] to 32,808 [91] . Seven studies mentioned the use of a theoretical model for their study, which includes the HBM [88] , the TPB [89] , the risk perception attitude framework [93] , the Triandis model of interpersonal behaviour [81] , the cognitive model of empowerment [99] or mixtures of different models [64, 79] (Table 1 ).

Thirty-six articles studied at least one predisposing factor in relation to vaccination uptake (Table 4) . Of the 30 articles that studied age, 22 found that older healthcare workers had a significantly higher uptake. On the other hand, in the case of hepatitis B [84, 95] and measles [78, 82] , younger HCW's had higher compliance. In the 27 papers that studied gender, being male was associated with higher vaccination uptake in 13 studies. Five papers mentioned a significantly higher uptake in women, one for rubella only [97] , and another for hepatitis B only [82] . Occupation was studied in relation to vaccination uptake in 18 articles. Sixteen papers showed that physicians had a significantly higher uptake than other HCW. This also complies with the significant positive association between education level and uptake that was found in five papers. Presence of a chronic disease resulted in significantly higher uptake in seven studies. In three other studies investigating this factor, no association was found. Having children at home was studied in nine papers, but six found no significant role for this factor in vaccination uptake. Good vaccine compliance in the past turned out to be an excellent predictor of uptake in all 11 studies investigating this factor.

The role of information sources in vaccination uptake was studied in six articles. When information was gathered from evidence-based sources, uptake was significantly higher in all five studies that investigated this source. On the other hand, uptake was lower when information was retrieved from social media, television, or radio [63, 92] . Only one study found that gaining information from colleagues was associated with a higher uptake [78] .

Perceived risk was the most frequently described determinant in HCWs. More specifically, perceived personal risk of infection reflects the perceived risk to contract the VPD, including the perceived susceptibility to get infected and the perceived severity of the disease if contracted. In 33 out of 35 papers mentioning perceived risk of infection, a significant positive relation was found between this determinant and vaccination uptake (n = 13), or these reasons were mentioned in a considerable part of the study group (n = 20). Furthermore, in 18 papers a high perceived risk to infect patients was given as a reason for vaccination uptake. Perceived risk (vs. benefit) of vaccination was mentioned in 34 papers. Fifteen studies reported a significant negative relation between perceived risk and uptake, indicating that high perceived risk or low perceived benefit of the vaccination resulted in lower uptake. Additionally, five papers mentioned that this determinant played a role in the majority of the study population. Adequate knowledge of recommendations, effectiveness, and side-effects of vaccinations was significantly positively associated with uptake in 11 papers; in four studies, no significant association was found. Attitude towards vaccination was studied in 22 articles. In half of them, a significant positive association with vaccination uptake was found. Social influence (encouragement of colleagues, managers, family) was analysed in almost half of the studies (n = 15). In only one study no association was found [66] , but the others showed either a significant (n = 8) or considerable (n = 6) positive relation with vaccination uptake. Specific for HCW are the social arguments 'I got vaccinated because it's my duty as an HCW' or 'as an HCW, I have a role in the prevention of epidemics/spread of diseases', that we collected under the term 'professional norms'. This determinant was positively associated with uptake in all 15 studies focusing on this factor; in seven out of 11 studies that tested for significance, this factor remained a strong predictor for uptake in multivariate analysis.

In comparison with the previous determinants, barriers and facilitators are relatively less studied. Of the barriers, time-related factors were mentioned most frequently and played a considerable role (>10%) in hindering uptake in seven studies. Costs turned out to be no barrier. The fact that the vaccines were free of charge even appeared to be a reason for uptake in two studies [62, 67] . On the other hand, facilitators stimulating uptake were getting a reminder (n = 3), convenient time/place of distribution (n = 4), and getting a reward (n = 3). However, in none of the studies were the potential rewards specified.

Our review of the currently available literature shows that there are clear differences in determinants that play a role in vaccination uptake in travellers, ICP, and HCW. For travellers, low perceived risk of infection and low awareness of vaccination recommendations are most accountable for low uptake. For ICP, awareness of the indication of vaccination plays an important role, together with receiving vaccination recommendations from their treating physician. ICP have a high perceived risk of vaccination, due to not only fear for general side-effects but also concerns about potential consequences for their illness. For HCW, perceived risk of (the severity of) infection for themselves and for their patients together with perceived benefits of vaccination contribute most to their vaccination behaviour.

Regarding predisposing factors, there is a clear positive relationship between age and influenza vaccination uptake in all risk groups. This could be explained by the additional indication older people have for influenza vaccination. However, for other vaccinations, this relationship is either inverted or non-existent. Higher vaccination uptake was seen in males in HCW and ICP, which could be associated with the fact that females worry more about vaccine safety and efficacy than males [107] . Indeed, more side-effects are reported by females, while on the other hand, from a biological perspective, females typically mount higher antibody responses [107] . Although we did not find a clear relationship between education level and vaccination uptake in the risk groups, in HCW the uptake was markedly higher in physicians compared to other HCW. Overall, vaccination history seems to be an excellent universal predictor of future vaccination uptake, probably due to unaltered cognitive determinants.

Regarding cognitive determinants, the greatest diversity between risk groups was found in awareness. In ICP, almost two-thirds of the studies mentioned limited awareness, compared to one-third in travellers and none in HCW. With their education and occupation, it seems quite obvious that HCW are aware of the opportunities and indications for vaccinations. The fact that ICP seem less aware than travellers might have to do with travellers taking an active decision to go abroad realizing that they have to prepare themselves, while patients get passively diagnosed with a disease, and are more dependant of the HCW for information provision. In all groups, HCW as a source of information has a positive effect on uptake. The strong relationship between HCW recommendations and vaccination uptake in ICP (reaching odds ratios up to 53 [52] and 187 [44] ), underline the importance of positive attitudes towards vaccination in HCW themselves [100, 108] .

In general, knowledge has a positive influence on uptake in all risk groups. However, since several studies showed no relation between knowledge and uptake [19, 35, 62, 66, 71, 95] , improving education alone will probably not be sufficient to increase uptake. In all groups, the perceived susceptibility and severity of diseases on one hand and the perceived effectiveness and risks of vaccinations on the other hand are important determinants predicting uptake. Especially ICP and HCW express concerns about the safety and effectiveness of vaccines particularly for influenza vaccination [38, 44] . And although the effectiveness of influenza vaccination varies with the coverage of circulating strains each year, another part of the perceived lack of effectiveness could also be explained by the lack of protection for other common cold viruses that can cause influenza-like symptoms [109] . Travelers seem to have low risk perceptions for the diseases they could be vaccinated for as well as for the potential negative effects of vaccination. Despite the high morbidity and mortality of some VPD such as yellow fever, hepatitis B, and influenza, in all risk groups, some participants stated they preferred natural immunization or were against vaccinations in general. Remarkably, attitudes differ for specific vaccinations, for instance, people tend to have a more positive attitude towards pneumococcal vaccination in comparison to the seasonal influenza vaccination [55] . Interestingly, the mistrust of ICP and HCW towards the vaccinations produced by the pharmaceutical industry seems disproportionate to therapeutics manufactured by the same pharmaceutical companies [40, 50, 72, 78] . Here, the difference between prevention and treatment might play a role, where the latter provides a more direct and visible effect. Another possible reason for the negative general attitude towards vaccination, also described in decision making for childhood vaccinations [110] , is the increasing tendency for self-empowerment towards personal health decisions. In this view, individuals stand up against imposed policies and want to make their own decisions, which could also be judged by peers as independent and smart decision making [110, 111] . At the same time, sources that are being used to make personal health decisions, such as the internet, contain a lot of negative stories [112] .

Practical barriers and facilitators play a limited role in vaccination uptake compared to the other determinants. In all three groups, a reminder is an important facilitator and (lack of) time an important barrier. Especially for HCW, this factor is interesting. Physicians report this factor most frequently [73] . They do not only experience lack of time to get vaccinated, they also feel that lack of time impedes their duty to recommend vaccinations to their patients [113] . Again, as HCW recommendations are strongly positively associated with uptake, not only in the other risk groups, but also for HCW themselves (by colleagues for example) [66, 80] , removing this barrier can result in achieving optimal care for all groups.

Only 16 of the 90 articles that were analysed in this review were based on a health behaviour model. Many of those found determinants which contributed to vaccination uptake to a greater or lesser extent [46, 64, 79, 93, 99] . Interventions that focus on a single determinant, such as knowledge, repeatedly proved to be ineffective in the past [66] , while multifactorial cognitive intervention strategies are effective to improve uptake [114, 115] . Therefore, all determinants that play a role have to be taken into account. Predisposing factors could be used to target specific subgroups and personalize uptake strategies [93] . Facilitators and barriers could be added or taken away to increase vaccination uptake. But, most importantly, interventions need to address cognitive determinants. Interventions that increase awareness and risk perception of infectious diseases are more effective than those decreasing risk perceptions of vaccination by providing scientific information [116] . Social norms can be influenced in the case of hierarchical relationships, for instance, the employer will have an effect on the vaccination decision of HCW and HCW will impact ICP's decisions. Therefore, multifactorial interventions are needed that address the most important cognitive determinants. As these include awareness and risk perceptions, reminders and incidence data could help. Reminders for travellers could be disseminated in general media before holidays, while for ICP patient associations and HCW could play a role. To improve risk perceptions for the infections, cases of vaccine-preventable diseases should be made public. To decrease risk perceptions of negative effects of vaccinations (e.g., adverse events) new studies should compare the number of influenza-like illnesses in vaccinated and non-vaccinated groups. Furthermore, social norms can be included by making the decisions of vaccination uptake public. For example, in HCW trials have been implemented to test the effects of providing a pin that vaccinated HCW may wear that is saying "deliberately vaccinated", which could affect both colleagues and patients [117] .

Vaccination decisions of travellers and ICP are less well studied than those of HCW. Additionally, data on uptake of vaccinations other than influenza are limited. As the available data show large differences in determinants predicting uptake of influenza versus other vaccinations, further studies are required regarding the uptake of recommended vaccinations for diseases other than influenza. Reaching a more comprehensive understanding of vaccination uptake in different risk groups for the different vaccinations that are indicated, interventions can be developed based on evidence. Moreover, this understanding could help with the implementation of new vaccines for certain risk groups, for instance when a novel SARS-CoV-2 vaccine will be recommended for HCW.

A number of limitations have to be taken into account when interpreting the results of this review. First, articles were only included if they discussed any cognitive determinants that were possibly related to vaccination uptake. This resulted in the exclusion of papers that looked only, although thoroughly, into predisposing factors. Secondly, there was a high level of heterogeneity in the determinants reported, as studies used various health behaviour models as a framework for their studies, and many did not even use a model but just reported results of questionnaires with either open-ended or multiple-choice questions. Furthermore, the influence of determinants on vaccination uptake was measured with different statistical analyses, which also contributed to the high heterogeneity of the data. Therefore, we choose to report the significance and direction of the association, instead of the magnitude. In addition, we choose to compare three different risk groups that we think are important, thereby we could not discuss all determinants in depth. Finally, included studies were based on self-reported vaccination behaviour. Therefore, we have to take into account a certain level of social desirability and recall bias.

To our knowledge, this is the first review that provides a comprehensive overview of health behavioural determinants explaining vaccination uptake in three different risk groups, namely travellers, ICP, and HCW. We showed that there is a large diversity of determinants that affect uptake to a greater or lesser extent. Therefore, we argue that future studies and interventions should be based on multifactorial health behaviour models, especially for travellers and ICP as only a limited number of such studies is available yet.

Supplementary Materials: The following are available online at http://www.mdpi.com/2076-393X/8/3/480/s1, Table S1 : Health behaviour theories on the basis of the I-Change model; Table S2 : Quality assessment of included articles, Supplementary File S1: Search strings databases. 

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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license

The authors wish to thank Sabrina Meertens-Gunput from the Erasmus MC Medical Library for developing and updating the search strategies.

The authors declare no conflict of interest.
