item: #1 of 549 id: cord-000008-3dgjv0x1 author: Vali, Bahareh title: HIV-Specific T-Cells Accumulate in the Liver in HCV/HIV Co-Infection date: 2008-10-20 words: 5272 flesch: 42 summary: Effect of human immunodeficiency virus on hepatitis C virus infection among injecting drug users Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection HIV longterm non-progressors maintain brisk CD8 T cell responses to other viral antigens CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection Comparison of HCV-specific intrahepatic CD4+ T cells in HIV/HCV versus HCV Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infection HIV-specific CD8+ lymphocytes in semen are not associated with reduced HIV shedding Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection The liver as a site of T-cell apoptosis: graveyard, or killing field? To determine the presence of intra-hepatic viral specific T-cell responses, liver isolated cells were stimulated with HCV and HIV peptide pools. keywords: cd8; cells; hcv; hiv; liver; responses cache: cord-000008-3dgjv0x1.txt plain text: cord-000008-3dgjv0x1.txt item: #2 of 549 id: cord-000065-6c3zb3g4 author: Nguyen, Thu Anh title: Health workers' views on quality of prevention of mother-to-child transmission and postnatal care for HIV-infected women and their children date: 2009-05-13 words: 6183 flesch: 52 summary: When giving the test result, health care workers should provide good counselling, including information about PMTCT options. Studies in Viet Nam have demonstrated that both HIVinfected and non-infected women had many criticisms of ANC and delivery services, about provision of information about PMTCT and counselling, and about stigma displayed by health care workers [3, 15] . keywords: anc; arv; care; health; hiv; hospital; patients; pmtct; services; women; workers cache: cord-000065-6c3zb3g4.txt plain text: cord-000065-6c3zb3g4.txt item: #3 of 549 id: cord-000077-d441jam3 author: Zhang, Hao-Jie title: The Y271 and I274 Amino Acids in Reverse Transcriptase of Human Immunodeficiency Virus-1 Are Critical to Protein Stability date: 2009-07-03 words: 5448 flesch: 46 summary: We tried to demonstrate this in vitro, by treating wild type and mutant RTs with recombinant protease, but wild type RT, as well as mutant RTs, could not be digested in vitro (data not shown). The conformation of the wild type and mutant RT p66 was further analyzed by native gel electrophoresis followed by Western blotting (Fig. 5B) . keywords: cells; fig; gag; immunodeficiency; mutants; mutations; p66; pol; transcriptase; type; virus cache: cord-000077-d441jam3.txt plain text: cord-000077-d441jam3.txt item: #4 of 549 id: cord-000130-dqqcajjd author: Smith?, Robert J title: The OptAIDS project: towards global halting of HIV/AIDS date: 2009-11-18 words: 2388 flesch: 49 summary: Mathematical models of the economy tell us whether a decrease in income tax will result in an increase in investment or an increase in imported consumer goods. Mathematical models of the atmosphere tell us what the effects of carbon dioxide emissions or of nuclear wars may be. keywords: aids; epidemic; hiv; life; models; project cache: cord-000130-dqqcajjd.txt plain text: cord-000130-dqqcajjd.txt item: #5 of 549 id: cord-000158-d08buwtu author: Corti, Davide title: Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals date: 2010-01-20 words: 8113 flesch: 40 summary: Passive transfer studies in macaques showed that the administration of HIV-1 neutralizing mAbs protects against vaginal or intravenous challenge with SIV-HIV-1 chimeric viruses (SHIV) Furthermore, selective pressure imposed by neutralizing antibodies has been demonstrated in a human trial where three neutralizing monoclonal antibodies (mAbs) administered during HAART treatment-interruption led to a reduction in viremia followed by selection of escape mutants [3, 4] . keywords: activity; antibodies; assay; binding; cells; clade; epitope; gp120; gp41; human; immunodeficiency; isolates; mabs; neutralization; type; virus cache: cord-000158-d08buwtu.txt plain text: cord-000158-d08buwtu.txt item: #6 of 549 id: cord-000638-ss1435el author: Beq, Stephanie title: Altered Thymic Function during Interferon Therapy in HCV-Infected Patients date: 2012-04-16 words: 5154 flesch: 37 summary: HIV-Hepatitis Spanish Study Group Future trends in managing hepatitis C Treatment of hepatitis C and anemia in human immunodeficiency virus-infected patients Use of pegylated interferons is associated with an increased incidence of infections during combination treatment of chronic hepatitis C: a side effect of pegylation? Incidence of neutropenia and infections during combination treatment of chronic hepatitis C with pegylated interferon alfa-2a or alfa-2b plus ribavirin Opportunistic infections and CD4 lymphocytopenia with interferon treatment in HIV-1 infected patients Regulation of cytokine expression by interferon-alpha in human bone marrow stromal cells: inhibition of hematopoietic growth factors and induction of interleukin-1 receptor antagonist Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia Impairment of T and B cell development by treatment with a type I interferon CD4+ T-lymphocytopenia in HIV-infected patients receiving interferon therapy for chronic hepatitis C. HIV-Hepatitis Spanish Study Group Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation Changes in thymic function with age and during the treatment of HIV infection Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection IL-7 induces immunological improvement in SIV-infected rhesus macaques under antiviral therapy T cell homeostasis: thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors The magnitude of thymic output is genetically determined through controlled intrathymic precursor T cell proliferation Estimating thymic function through quantification of T-cell receptor excision circles Interleukin-7 treatment counteracts IFN-{alpha} therapy-induced lymphopenia and stimulates SIV-specific cytotoxic T lymphocyte responses in SIV-infected rhesus macaques Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1) The role of interleukin-7 in early T-cell development A direct estimate of the human alphabeta T cell receptor diversity How cells respond to interferons Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells Down-regulation of p27Kip1 expression is required for development and function of T cells Endogenous interferon-alpha production by differentiating human monocytes regulates expression and function of the IL-2/IL-4 receptor gamma chain Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood Tlymphocyte populations in hepatitis C and HIV co-infected patients treated with interferon-alfa-2a and ribavirin Interferon alpha augments activation-induced T cell death by upregulation of Fas (CD95/APO-1) and Fas ligand expression IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis Rapid decline of CD4+ cells after IFN alpha treatment in HIV-1 infection Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells Hepatic interleukin-7 expression regulates T cell responses Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence Interleukin-7 receptor expression: intelligent design Hepatitis C virus (HCV) genotype 1 subtype identification in new HCV drug development and future clinical practice Determinants of antiviral treatment initiation in a hepatitis C-infected population benefiting from universal health care coverage Response rates to pegylated interferon and ribavirin in HCV/HIV coinfection: a research synthesis Rare birds in North America: acute hepatitis C cohorts A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment The authors acknowledge the subjects who participated in this study. keywords: cell; figure; hcv; hiv; ifna; il-7; patients; plasma; proliferation; therapy cache: cord-000638-ss1435el.txt plain text: cord-000638-ss1435el.txt item: #7 of 549 id: cord-000736-6f8vyziv author: Pripuzova, Natalia title: Development of Real-Time PCR Array for Simultaneous Detection of Eight Human Blood-Borne Viral Pathogens date: 2012-08-17 words: 6827 flesch: 47 summary: The results of sensitivity testing of the real-time PCR array primer sets specific for HIV-1, HIV-2, HBV, HCV, and WNV the with FDA/CBER analytical plasma panels. Example of the experimental testing of HIV-1 specific primer set targeting gag gene (NP3/4) for its sensitivity with DNA analytical standards is shown in Figure S1 . keywords: array; copies; dna; hiv-1; human; pcr; plasma; primer; samples; sets; specific; virus cache: cord-000736-6f8vyziv.txt plain text: cord-000736-6f8vyziv.txt item: #8 of 549 id: cord-000849-rrezynbs author: Kumar, Rajesh title: A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C date: 2012-11-15 words: 7540 flesch: 54 summary: It was also tested for the presence of binding anti-V3 antibodies and the data is shown in Figure 1 . After 2 weeks, the cultures were screened (first screening) for the presence of anti-V3 antibodies and 7/48 wells showed high V3 binding reactivity with OD> 2. keywords: antibodies; antibody; binding; cells; clones; ebv; hiv-1; human; library; min; phage; scfv cache: cord-000849-rrezynbs.txt plain text: cord-000849-rrezynbs.txt item: #9 of 549 id: cord-000868-vnwpzsu8 author: Eissmann, Kristin title: HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop date: 2013-01-22 words: 9147 flesch: 46 summary: We demonstrate that E2 peptides act late after CD4 and coreceptor engagement via binding the gp41 disulfide loop region, a new promising target for HIV-1 entry inhibition. PHA/IL-2-stimulated PBMC or TZM-bl cells were incubated with E2 peptides (25 mM), phorbol 12-myristate 13-acetate (PMA; 40 ng/ml), SDF-1a (1 mg/ml) or RANTES (50 nM) for 6 hr. keywords: binding; c e2; cd4; cells; disulfide; entry; fusion; gbv; gp120; gp41; hiv; loop; peptides; protein; region; virus cache: cord-000868-vnwpzsu8.txt plain text: cord-000868-vnwpzsu8.txt item: #10 of 549 id: cord-001079-v01vwu00 author: Thoden, J. title: Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066) date: 2013-09-14 words: 12704 flesch: 36 summary: The review presented here is a translation of a short version of the German–Austrian Guidelines of opportunistic infections in HIV patients. Results of the Swiss HIV Cohort Study prove that consequent isoniazid (INH)-prophylaxis in HIV patients with latent TB significantly reduces the risk of a relapse [22] . keywords: aids; art; candidiasis; cases; cd4; cmv; fluconazole; guidelines; hiv; immunodeficiency; infection; patients; prophylaxis; retinitis; study; therapy; treatment; trial; virus cache: cord-001079-v01vwu00.txt plain text: cord-001079-v01vwu00.txt item: #11 of 549 id: cord-001228-4eh22ek7 author: Ofori, Leslie O. title: High-Affinity Recognition of HIV-1 Frameshift-Stimulating RNA Alters Frameshifting in Vitro and Interferes with HIV-1 Infectivity date: 2014-01-05 words: 6309 flesch: 46 summary: All titrations started at a volume of 500 μL with the compound at 1 μM. RNA was then titrated in from a highconcentration stock (10 μM for HIV-1 FSS RNA; 40 μM for HIV-1 FSS DNA and tRNA) in 1−10 μL increments. While an RNA stem-loop structure (the “HIV-1 Frameshift Stimulating Signal”, or HIV-1 FSS) controls the frameshift efficiency and has been hypothesized as an attractive therapeutic target, developing compounds that selectively bind this RNA and interfere with HIV-1 replication has proven challenging. keywords: affinity; assay; binding; cells; compounds; frameshift; frameshifting; fss; gag; pol; rna; stem; virus cache: cord-001228-4eh22ek7.txt plain text: cord-001228-4eh22ek7.txt item: #12 of 549 id: cord-001385-rb5vwolt author: Reuven, Eliran Moshe title: The HIV-1 Envelope Transmembrane Domain Binds TLR2 through a Distinct Dimerization Motif and Inhibits TLR2-Mediated Responses date: 2014-08-14 words: 6173 flesch: 46 summary: These results suggest that incubation of gp41 TMD peptides with cells leads to inhibition of TLR2/6 signaling. Mice were injected intraperitoneally (i.p) with 100 mg of LTA and 700 mg/kg Dgalactosamine (GLN), and were either treated intravenous (i.v.) with gp41 TMD peptide (5 mg/kg), mutated peptide (5 mg/kg) or PBS. keywords: activation; cells; env; expression; figure; gp41; levels; lta; membrane; peptide; protein; tlr2; tmd; tmds; tnfa cache: cord-001385-rb5vwolt.txt plain text: cord-001385-rb5vwolt.txt item: #13 of 549 id: cord-001532-kz3b01wq author: Gantt, Soren title: Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation date: 2015-01-29 words: 4375 flesch: 41 summary: The Akt inhibitor LY294002 completely suppressed Akt phosphorylation in HSV-1 infected cells, but NFV did not reduce the levels of phosphorylated Akt even at drug concentrations that potently block virus production ( Figure 3 ). We were not able to formally show that NFV increased autophagy in HSV-1 infected cells under the conditions used. keywords: activity; anti; autophagy; cells; herpes; hiv; hsv-1; nelfinavir; nfv; protease; protein; virus cache: cord-001532-kz3b01wq.txt plain text: cord-001532-kz3b01wq.txt item: #14 of 549 id: cord-001707-piyo00yg author: Murray, Jillian title: Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology date: 2015-07-08 words: 3880 flesch: 45 summary: Other countries that have influenza surveillance in place can also implement this methodology to estimate their national burden of severe influenza disease. Excess mortality due to pneumonia or influenza during influenza seasons among persons with acquired immunodeficiency syndrome Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1 Severe influenza-associated respiratory infection in high HIV prevalence setting, South Africa Naturally-acquired influenza-specific CD4+ T-cell proliferative responses are impaired in HIV-infected African adults Influenza surveillance in 15 countries in Africa Lower respiratory tract infections associated with influenza A and B viruses in an area with a high prevalence of pediatric human immunodeficiency type 1 infection Seasonal influenza epidemiology in sub-Saharan Africa: a systematic review Twenty-five years of outpatient influenza surveillance in South Africa Recommendations pertaining to the use of viral vaccines: influenza 2013 Regional perspectives on influenza surveillance in Africa Strategy to enhance influenza surveillance worldwide World Health Organization. keywords: cases; hiv; influenza; province; sari; south cache: cord-001707-piyo00yg.txt plain text: cord-001707-piyo00yg.txt item: #15 of 549 id: cord-001972-1zisomq5 author: Wang, Xue title: Pandemic Influenza A (H1N1) Virus Infection Increases Apoptosis and HIV-1 Replication in HIV-1 Infected Jurkat Cells date: 2016-02-02 words: 3942 flesch: 39 summary: It is not well-known whether influenza virus infection affects cell death and human immunodeficiency virus (HIV)-1 replication in HIV-1-infected patients. Little is known about influenza virus infection in HIV-positive individual. keywords: cells; infected; infection; influenza; jurkat; pandemic; pathways; ph1n1; replication; virus cache: cord-001972-1zisomq5.txt plain text: cord-001972-1zisomq5.txt item: #16 of 549 id: cord-002746-qn34eyul author: Antzin-Anduetza, Irati title: Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication date: 2017-11-09 words: 9127 flesch: 51 summary: HIV-1 RNA has a high percentage of adenine (A, 36%) and low percentage of cytosine (C, 18%) If this occurred, gRNA abundance would decrease due to oversplicing but the total amount of HIV-1 RNA would stay the same. keywords: abundance; cells; cm22; codon; cpg; dinucleotides; expression; fig; gag; grna; hiv-1; infectivity; replication; rna; sequence; type; virus cache: cord-002746-qn34eyul.txt plain text: cord-002746-qn34eyul.txt item: #17 of 549 id: cord-002757-upwe0cpj author: Sullivan, Kathleen E. title: Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies date: 2017-08-07 words: 24227 flesch: 37 summary: Importantly, after a novel PIDD has been described, subsequent reports often reveal a wider variation in associated infections and cellular findings, often without clear genotype-phenotype correlations [320] [321] Human infection, called Cat Scratch Disease, is assumed to involve inoculation of Bartonella-infected flea feces into the skin during a cat scratch. keywords: associated; azole; bartonella; cases; cause; cell; children; chronic; clinical; cns; countries; days; deficiency; dengue; diagnosis; disease; epidemiology; fever; hiv; human; immune; immunodeficiency; immunoglobulin; individuals; infection; influenza; mandrillaris; patients; pcr; pidd; primary; resistance; review; risk; skin; species; susceptibility; symptoms; syndrome; therapy; tick; transmission; treatment; vaccination; vaccine; virus cache: cord-002757-upwe0cpj.txt plain text: cord-002757-upwe0cpj.txt item: #18 of 549 id: cord-002774-tpqsjjet author: None title: Section II: Poster Sessions date: 2017-12-01 words: 83566 flesch: 48 summary: The CHIP framework drives the complex inter-relationships between community-hospital engagement, reciprocal capacity-building, integration initiatives, and community-based research and evaluation, to create an interconnected network of health care services. Those living in urban centers should have the best ava1l~b1hty, chmce, and access to a variety of health care services because of the distribution of health care services, fac1lmes, and health professionals in concentrated in urban centers. keywords: access; address; age; aids; analysis; approach; areas; barriers; canada; cancer; care services; care system; case; child health; children; cities; city; clients; clinic; communities; community health; community services; conclusion; conditions; current; data; demographic; depression; development; disease; drug; education; effects; environmental; ethnic; experience; factors; family; findings; focus; food; government; group; health care; health centre; health education; health information; health insurance; health issues; health needs; health outcomes; health policy; health problems; health promotion; health research; health services; health status; health survey; health system; healthcare; help; hiv; homeless; hospital; housing; immigrants; impact; income; individuals; information; interventions; interviews; introduction; issues; key; knowledge; lack; level; life; living; low; medical; methods; model; mortality; national; neighborhood; new; non; number; paper; participants; patients; people; physical; poor; population; population health; poster; poverty; prevalence; prevention; primary; process; program; project; provide; providers; public; quality; rates; relationship; research; residents; resources; results; risk; role; sample; self; sessions; sexual; social; strategies; street; street health; studies; study; substance; support; survey; system; time; toronto; treatment; urban; use; users; women; work; workers; years; youth cache: cord-002774-tpqsjjet.txt plain text: cord-002774-tpqsjjet.txt item: #19 of 549 id: cord-003307-snruk3j2 author: Schmidt, Julius J. title: Clinical course, treatment and outcome of Pneumocystis pneumonia in immunocompromised adults: a retrospective analysis over 17 years date: 2018-11-19 words: 4069 flesch: 45 summary: Cochrane HIV/AIDS Group Use of adjunctive corticosteroids in severe adult non-HIV Pneumocystis carinii pneumonia Incidence of Pneumocystis jiroveci pneumonia among groups at risk in HIV-negative patients Pneumocystis pneumonia suspected cases in 604 non-HIV and HIV patients Infectious disease ward admission positively influences P. jiroveci pneumonia (PjP) outcome: a retrospective analysis of 116 HIV-positive and HIV-negative immunocompromised patients Population-based analysis of invasive fungal infections Pneumocystis pneumonia in HIV-infected and immunocompromised non-HIV infected patients: a retrospective study of two centers in China Outcomes and prognostic factors of non-HIV patients with pneumocystis jirovecii pneumonia and pulmonary CMV co-infection: a retrospective cohort study Predisposing factors, clinical characteristics and outcome of Pneumonocystis jirovecii pneumonia in HIV-negative patients Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients Intensive care of patients with HIV infection: utilization, critical illnesses, and outcomes. However, when ICU patients were analyzed separately, we observed that the addition of age as a variable increased the predictive performance of LDH alone from an AUC of 0.61 (95% CI 0.49-0.72) to an AUC of 0.71 (95% CI 0.60-0.81) (p = 0.024). keywords: hiv; hospital; ldh; mortality; non; patients; pcp; pneumocystis; pneumonia cache: cord-003307-snruk3j2.txt plain text: cord-003307-snruk3j2.txt item: #20 of 549 id: cord-003715-deqiets2 author: Warren, Cody J. title: Selective use of primate CD4 receptors by HIV-1 date: 2019-06-10 words: 9569 flesch: 50 summary: Macrophage-tropic HIV-1 isolates, which are known to bind human CD4 more tightly, are promiscuous in their use of primate CD4 receptors. This pattern of increased binding affinity for human CD4 and increased ability to enter cells via primate CD4s also correlated to increased binding affinity for primate CD4 receptors, as read in a neutralization assay with purified chimpanzee and rhesus macaque sCD4 proteins (left to right in Fig 4C) . keywords: binding; blood; ccr5; cd4; cells; entry; env; envs; fig; human; infection; isolates; macaque; primate; receptors; species; use; virus cache: cord-003715-deqiets2.txt plain text: cord-003715-deqiets2.txt item: #21 of 549 id: cord-003764-141u6ax7 author: Shrestha, Ashish C. title: Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines date: 2019-04-30 words: 6314 flesch: 34 summary: Emerg Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity Effective humoral immune response from a H1N1 DNA vaccine delivered to the skin by microneedles coated with PLGA-based cationic nanoparticles Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3 Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus Clinical applications of DNA vaccines: Current progress DNA Vaccines-How Far From Clinical Use? DNA Vaccines: However, one of the major challenges for the development of DNA vaccines is their poor immunogenicity in humans, which has led to refinements in DNA delivery, dosage in prime/boost regimens and the inclusion of adjuvants to enhance their immunogenicity. keywords: antigen; cells; dcs; dna; encoding; immunogenicity; ns3; prf; protein; responses; vaccine; virus cache: cord-003764-141u6ax7.txt plain text: cord-003764-141u6ax7.txt item: #22 of 549 id: cord-003895-m1y76ee5 author: Parcesepe, Angela M. title: Gender, HIV-Related Stigma, and Health-Related Quality of Life Among Adults Enrolling in HIV Care in Tanzania date: 2019-03-30 words: 4783 flesch: 41 summary: HIV infection as a chronic disease Measuring healthy days: population assessment of health-related quality of life Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence Health-related quality of life and survival among HIV-infected patients receiving highly active antiretroviral therapy: a study of patients in the AIDS Therapy Evaluation in the Netherlands (ATHENA) Cohort Predicting health-related quality of life in people living with HIV in Nepal: mental health disorders and substance use determinants Gender differences and psychosocial factors associated with quality of life among ART initiators in Oromia Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: a series of meta-analyses The role of HIV stigma in ART adherence and quality of life among rural women living with HIV in India Perceived social support, coping, and stigma on the quality of life of people living with HIV in Nepal: a moderated mediation analysis From conceptualizing to measuring HIV stigma: a review of HIV stigma mechanism measures HIV/AIDS National Strategic Plans of Sub-Saharan African countries: an analysis for gender equality and sex-disaggregated HIV targets Gender and care: access to HIV testing, care, and treatment Gender differences in disclosure concerns and HIV-related quality of life Gendered aspects of perceived and internalized HIV-related stigma in China Stigma in HIV-positive women Performance of a new, HIV/AIDS-targeted quality of life (HAT-QoL) instrument in asymptomatic seropositive individuals HIV/ AIDS-specific quality of life and adherence to antiretroviral therapy over time Reliability and validity of two HIV/AIDS-specific quality of life instruments adapted for use in HIV-positive Zimbabweans Quality of life and the concept of living well with HIV/AIDS in sub-Saharan Africa Validation of the HIV/AIDS Stigma Instrument-PLWA (HASI-P) Gender differences in health-related quality of life at the time of a positive HIV test-a cross-sectional study in a resource-poor, high prevalence setting in Gender differences in health related quality of life among people living with HIV on highly active antiretroviral therapy in Mekelle Town The relationship between stigma and health-related quality of life in people living with HIV who have full access to antiretroviral treatment: an assessment of Earnshaw and Chaudoir's HIV stigma framework using empirical data Stigma in Ethiopia: association with depressive symptoms in people with HIV Stigma and discrimination against people living with HIV by healthcare providers, Southwest Ethiopia HIV-stigma in Nigeria: review of research studies, policies, and programmes Enacted and internalized stigma and quality of life among people with HIV: the role of group identity The social context of food insecurity among persons living with HIV/AIDS in rural Uganda High levels of adherence and viral suppression in a nationally representative sample of HIV-infected adults on antiretroviral therapy for 6, 12 and 18 months in Rwanda Effect of peer health workers on Randomized control trial of peer-delivered, modified directly observed therapy for HAART in Mozambique HIV testing and stigma: the association of HIV testing behaviors and community-level and individuallevel stigma in rural South Africa differ for men and women Acknowledgements This project was supported by a research grant from the National Institute of Mental Health (Supplement to Grant Number R01MH089831). HIV-related stigma can take many forms including anticipatory stigma, internalized stigma, and enacted stigma. keywords: hiv; hrqol; life; quality; relationship; stigma; women cache: cord-003895-m1y76ee5.txt plain text: cord-003895-m1y76ee5.txt item: #23 of 549 id: cord-004002-b35wm2db author: Gaborit, Benjamin Jean title: Outcome and prognostic factors of Pneumocystis jirovecii pneumonia in immunocompromised adults: a prospective observational study date: 2019-11-27 words: 4895 flesch: 34 summary: Lymphocytes and neutrophils mean ratio were, respectively, 22% and 23% in HIV patients, 34% and 21% in non-HIV patients, 22% and 30% in dead patients, 35% and 19% in survivors patients, 36% and 21% with only PJP patients, 29% and 22% during coinfection. In survival analysis HIV patients presenting with PJP was associated with statistically better prognostic than that of patients with hematologic diseases or solid cancer (Additional file 1: Figures S2, S3) . keywords: bal; day; fluid; hiv; jirovecii; mortality; patients; pjp; pneumocystis; pneumonia cache: cord-004002-b35wm2db.txt plain text: cord-004002-b35wm2db.txt item: #24 of 549 id: cord-004031-sw60qbbj author: Aylward, Ryan E. title: Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study date: 2019-12-10 words: 4297 flesch: 50 summary: Although ICU length of stay was less in HIV patients with AKI (median ICU days 3 vs 6, p = 0.002), the proportion of patients with HIV who died within the first 24 h was higher at 10.5% compared to 2.6% in those who were HIV negative, p = 0.009. HIV positive patients that developed AKI were receiving Tenofovir-based HAART at the time of ICU admission. keywords: acute; aki; associated; hiv; icu; injury; kidney; mortality; patients cache: cord-004031-sw60qbbj.txt plain text: cord-004031-sw60qbbj.txt item: #25 of 549 id: cord-004198-h8ch3x14 author: Ebuy, Hiluf title: HIV testing, test results and factors influencing among infants born to HIV positive mothers in public hospitals of Mekelle City, North Ethiopia: a cross-sectional study date: 2020-01-21 words: 4506 flesch: 52 summary: key: cord-004198-h8ch3x14 authors: Ebuy, Hiluf; Bekele, Alemayehu; Redae, Getachew title: HIV testing, test results and factors influencing among infants born to HIV positive mothers in public hospitals of Mekelle City, North Ethiopia: a cross-sectional study date: 2020-01-21 journal: BMC Infect Dis DOI: 10.1186/s12879-020-4790-9 sha: doc_id: 4198 cord_uid: h8ch3x14 BACKGROUND: Timely infant testing for HIV is critical to ensure optimal treatment outcomes among exposed infants. There were 291(52.2%) female HIV exposed infants (Table 1) PMTCT service and clinical characteristics among mothers The majority (95.0%) of the mothers had attended ANC and 529(94.8%) mothers were on ART on entry to the PMTCT cohort. keywords: ethiopia; health; hiv; infants; mothers; positivity; study; testing cache: cord-004198-h8ch3x14.txt plain text: cord-004198-h8ch3x14.txt item: #26 of 549 id: cord-004247-lagv3tp7 author: Hooft van Huijsduijnen, Rob title: Reassessing therapeutic antibodies for neglected and tropical diseases date: 2020-01-30 words: 6767 flesch: 40 summary: In 2 cases, the specific antibodies produced could be identified using B cell cloning [81] or after infection of mice genetically modified to express human antibody repertoires Other recent successes have included new antibodies for use in viral diseases, including HIV. keywords: antibodies; antibody; cell; dengue; diseases; fungal; human; infection; mabs; mice; patients; protection; protein; response; studies; treatment cache: cord-004247-lagv3tp7.txt plain text: cord-004247-lagv3tp7.txt item: #27 of 549 id: cord-004335-bw3tziup author: Perez-Zsolt, Daniel title: When Dendritic Cells Go Viral: The Role of Siglec-1 in Host Defense and Dissemination of Enveloped Viruses date: 2019-12-19 words: 7388 flesch: 32 summary: A mathematical modelling study A case of Ebola virus infection Assessment of the risk of Ebola virus Transmission from bodily fluids and fomites Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts Enhancement of Ebola virus infection by seminal amyloid fibrils Transforming growth factor beta 1 up-regulates CD169 (sialoadhesin) expression on monocytederived dendritic cells: Role in HIV sexual transmission The dendritic cell system and its role in immunogenicity Dendritic cells and the control of immunity Visualizing priming of virus-specific CD8 + T cells by infected dendritic cells in vivo Endogenous MHC class II processing of a viral nuclear antigen after autophagy Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity Dendritic cells in viral pathogenesis: Protective or defective? Anti-immunology: Evasion of the host immune system by bacterial and viral pathogens Dendritic cell functions: Learning from microbial evasion strategies Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4 + T cells Bone marrow-derived dendritic cells, infection with human immunodeficiency virus, and immunopathology Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: Evidence that dendritic cells are early and sustained targets of infection Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques The molecule of DC-SIGN captures enterovirus 71 and confers dendritic cell-mediated viral trans-infection Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN Dendritic cells as Achilles' heel and Trojan horse during varicella zoster virus infection Murine cytomegalovirus spreads by dendritic cell recirculation DC-SIGN and CD150 have distinct roles in transmission of measles virus from dendritic cells to T-lymphocytes Replication in cells of hematopoietic origin is necessary for Dengue virus dissemination Siglecs and their roles in the immune system HIV-1 capture and transmission by dendritic cells: The role of viral glycolipids and the cellular receptor Siglec-1 CD169-dependent cell-associated HIV-1 transmission: A driver of virus dissemination Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides Role of lipids in virus replication Sialyllactose in viral membrane gangliosides is a novel molecular recognition pattern for mature dendritic cell capture of HIV-1 Lipid raft microdomains: A gateway for compartmentalized trafficking of Ebola and Marburg viruses Quantifying lipid contents in enveloped virus particles with plasmonic nanoparticles In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding Siglec regulation of immune cell function in disease Sialic acid binding receptors (siglecs) expressed by macrophages Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection A protective role for the lectin CD169/Siglec-1 against a pathogenic murine retrovirus Available online The pathogenesis of Ebola virus disease Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169 Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells Interferon-alpha and tumor necrosis factor-alpha in serum of patients in various stages of HIV-1 infection Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections Microbial translocation is a cause of systemic immune activation in chronic HIV infection The nature of the principal type 1 interferon-producing cells in human blood CD4 + blood dendritic cells are potent producers of IFN-alpha in response to in vitro HIV-1 infection Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor Ligands Innate sensing of HIV-infected cells Increased interferon alpha expression in circulating plasmacytoid dendritic cells of HIV-1-infected patients Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1 Dendritic cells from the cervical mucosa capture and transfer HIV-1 via Siglec-1 Maturation, activation, and protection of dendritic cells induced by double-stranded RNA Type I interferons produced by dendritic cells promote their phenotypic and functional activation A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells Autocrine type I interferon amplifies dendritic cell responses to lipopolysaccharide via the nuclear factor-κB/p38 pathways Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections Intestinal damage precedes mucosal immune dysfunction in SIV infection Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides Markedly elevated levels of interferon (IFN)-γ, IFN-α, interleukin (IL)-2, IL-10, and tumor necrosis factor-α associated with fatal Ebola virus infection In vivo Ebola virus infection leads to a strong innate response in circulating immune cells Human asymptomatic Ebola infection and strong inflammatory response Ebola virus failure to stimulate plasmacytoid dendritic cell interferon responses correlates with impaired cellular entry Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants Ebola virus-like particles stimulate type keywords: cells; dcs; dendritic; ebola; ebov; figure; immune; infection; siglec-1; type; viral; virus; viruses cache: cord-004335-bw3tziup.txt plain text: cord-004335-bw3tziup.txt item: #28 of 549 id: cord-004395-erqmbi2b author: Bugembe, Daniel Lule title: Computational MHC-I epitope predictor identifies 95% of experimentally mapped HIV-1 clade A and D epitopes in a Ugandan cohort date: 2020-02-22 words: 4415 flesch: 37 summary: In this analysis we showed that the computational method NetMHCpan4.0 predicted 95% of previously experimentally mapped HIV-1 epitopes in 6 HIV-1 infected individuals expressing a total of 22 different HLA class I alleles. A community resource benchmarking predictions of peptide binding to MHC-I molecules Efficient peptide-MHC-I binding prediction for alleles with few known binders MULTIPRED: a computational system for prediction of promiscuous HLA binding peptides Automated benchmarking of peptide-MHC class I binding predictions An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions Largescale validation of methods for cytotoxic T-lymphocyte epitope prediction Reliable prediction of T-cell epitopes using neural networks with novel sequence representations MHCflurry: open-source class I MHC binding affinity prediction T-cell antigenic sites tend to be amphipathic structures Emerging vaccine informatics Prediction of peptide-MHC binding using profiles Comparison of experimental fine-mapping to in silico prediction results of HIV-1 epitopes reveals ongoing need for mapping experiments Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection Macrophage inflammatory Protein-1 keywords: binders; binding; cell; class; computational; data; epitopes; hla; netmhcpan4.0; peptides; predictions cache: cord-004395-erqmbi2b.txt plain text: cord-004395-erqmbi2b.txt item: #29 of 549 id: cord-004501-guiy89x8 author: Cojocaru, Florina-Daniela title: Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers date: 2020-02-18 words: 14004 flesch: 30 summary: A reality for diagnosis of HCV infectious disease HIV biosensors for early diagnosis of infection: The intertwine of nanotechnology with sensing strategies Chitosan as a bioactive polymer: Processing, properties and applications Anti-Herpes Simplex Virus (HSV-1 and HSV-2) activity of biogenic gold and silver nanoparticles using seaweed Sargassum wightii A novel extracellular synthesis of monodisperse gold nanoparticles using marine alga, Sargassum wightii Greville Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism Inhibition of Human Metapneumovirus Binding to Heparan Sulfate Blocks Infection in Human Lung Cells and Airway Tissues Pathogen Inhibition by Multivalent Ligand Architectures Surface-structureregulated cell-membrane penetration by monolayer-protected nanoparticles Antiherpes evaluation of soybean isoflavonoids Topical Delivery of Coumestrol from Lipid Nanoemulsions Thickened with Hydroxyethylcellulose for Antiherpes Treatment Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery Novel dendritic structure of alginate hybrid nanoparticles for effective anti-viral drug delivery Design of antiretroviral drug-polymeric nanoparticles laden buccal films for chronic HIV therapy in paediatrics Influence of Solvent Evaporation Technique Parameters on Diameter of Submicron Lamivudine-Poly-ε-Caprolactone Conjugate Particles Nanoencapsulation of water-soluble drug, lamivudine, using a double emulsion spray-drying technique for improving HIV treatment Formulation and characterisation of chitosan based lamivudine nanoparticles The Antiretroviral Agent Nelfinavir Mesylate: A Potential Therapy for Systemic Sclerosis Inhibition of HIV Fusion with Multivalent Gold Nanoparticles Gold Nanoparticles as an HIV Entry Inhibitor Gold nanoparticles to improve HIV drug delivery The role of nanotechnology in the treatment of viral infections Epaxal ® : A virosomal vaccine to prevent hepatitis A infection Pharmacokinetics and Pharmacodynamics Modeling and Simulation Systems to Support the Development and Regulation of Liposomal Drugs Eleven years of Inflexal ® V-A virosomal adjuvanted influenza vaccine Package Insert PEG-IntronTM (Peginterferon alfa-2b) Powder for Injection, Schering Corporation Progress in Nanomedicine: Approved and Investigational Nanodrugs Tolerability and Immune Response to LC002, an Experimental Therapeutic Vaccine Bioavailability of MK-1439 Experimental Nano Formulations in Healthy Adults (MK-1439-046)-ClinicalTrials.gov There are several factors that hinder the development of antiviral drugs: • Dependence of viruses replication on host cell biosynthetic machinery keywords: activity; acv; antiviral; barrier; bbb; blood; brain; cell; costs; delivery; dna; drug; drug delivery; hiv; impact; infection; inhibitors; mechanism; membrane; nanoparticles; nanotechnology; nps; review; skin; studies; therapy; treatment; virus; viruses; vitro cache: cord-004501-guiy89x8.txt plain text: cord-004501-guiy89x8.txt item: #30 of 549 id: cord-004575-b0t6bsya author: Staub, Roger title: Haben HIV-Positive eine besondere Verantwortung?: Ein Diskussionsbeitrag date: 2007-03-27 words: 1954 flesch: 51 summary: On this background, the paper examines from an ethical perspective to what extent people with HIV have a responsibility in HIV prevention. It finally claims for stronger obligations for sex businesses to support HIV prevention. keywords: auch; auf; dass; den; der; des; die; für; health; hiv; ist; mit; sich; sie; und; von cache: cord-004575-b0t6bsya.txt plain text: cord-004575-b0t6bsya.txt item: #31 of 549 id: cord-004600-5lhnzzvg author: Dennin, Reinhard H. title: HIV-Infektion – Grenzen der Präventionskonzepte: Überlegungen zur Verantwortung der Betroffenen, der Politik und der Gesellschaft* date: 2007-03-26 words: 2695 flesch: 39 summary: Zur Sache, Themen parlamentarischer Beratung Applying public health principles to the HIV epidemic Screening for HIV: a review of the evidence for the U.S. preventive service task force Revised recommendations for HIV testing for adults, adolescents, and pregnant women in health care settings Deutsche AIDS Hilfe Notes and quotes. Die Koevolution von HIV mit seinem neuen Wirt Homo sapiens hat erst begonnen; gefördert wird sie allerdings nur von jenen Menschen der Gesellschaft, die die HIV-Infektion verbreiten, die sich der HIV-Infektion aussetzen oder ihr ausgesetzt werden -z. keywords: aids; als; auch; auf; bei; das; den; der; des; die; eine; für; health; hiv; infektion; ist; menschen; mit; nicht; rights; und; von; werden; zur cache: cord-004600-5lhnzzvg.txt plain text: cord-004600-5lhnzzvg.txt item: #32 of 549 id: cord-004827-bnf3mvaf author: Desselberger, U. title: Report on an ICTV-sponsored symposium on Virus Evolution date: 2005-01-13 words: 2768 flesch: 43 summary: The viruses and their replication Molecular evidence of HIV-1 transmission in a criminal case The nonclonal and transitory nature of HIV in vivo Don't forget about viruses Topological organization of picornaviral genomes: Statistical prediction of RNA structural signals New real-time reverse transcriptase-initiated PCR assay with single-copy sensitivity for human immunodeficiency virus type 1 RNA in plasma Reproducible nonlinear population dynamics and critical points during replicative competitions of RNA virus quasispecies Retroids in Archaea: phylogeny and lateral origins The structure of a thermophilic archaeal virus shows a double stranded DNA viral capsid that spans all domains of life Generation of coronavirus spike deletion variants by high-frequency recombination at regions of predicted RNA secondary structure Evolutionary history of Cucumber mosaic virus deduced by phylogenetic analyses Plant RNA virus evolution Synchronous loss of quasispecies memory in parallel viral lineages: a deterministic feature of viral quasispecies Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) New Haven CT 30. A new model for coronavirus transcription Genetic diversity in RNA virus quasispecies is controlled by host-virus interaction Unique and conserved features of genome and proteome of SARS-coronavirus, an early split off from the coronavirus group 2 lineage Of statistics and genomes VP1 of infectious bursal disease virus is an RNA dependent RNA polymerase The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs On finding all suboptimal foldings of an RNA molecule Prediction of RNA secondary structure by energy minimization Parc d'Innovation, Boulevard Sébastian Brandt, 67400 Illkirch, France. keywords: cell; evolution; genome; hiv; quasispecies; recombination; rna; structure; virus; viruses cache: cord-004827-bnf3mvaf.txt plain text: cord-004827-bnf3mvaf.txt item: #33 of 549 id: cord-004986-en7taikk author: Nagy, Nathalie title: Infections gastro-intestinales chez le patient immunocompromis date: 2002 words: 6150 flesch: 50 summary: Certaines 6tudes rapportent des strongyloidoses diss6min6es chez des patients immunocompromis. Bien avant les 6pid6mies de sida, le toxoplasme 6tait reconnu comme protozoaire responsable d'infections opportunistes chez les patients immunocompromis. keywords: aids; aux; cd4; chez; cmv; dans; des; est; hiv; immunocompromis; infections; les; niveau; par; patients; que; sida; sont; tract; une cache: cord-004986-en7taikk.txt plain text: cord-004986-en7taikk.txt item: #34 of 549 id: cord-005033-voi9gu0l author: Xuan, Huiyu title: A CA-based epidemic model for HIV/AIDS transmission with heterogeneity date: 2008-06-07 words: 6569 flesch: 53 summary: Ignoring the mobility of agents in epidemic models would jeopardize the creditability of the results obtained. Classical epidemic models divide the closed population into three subgroups: susceptible, infective, and recovered (removed). keywords: agent; aids; epidemic; hiv; infection; model; neighborhood; state; time cache: cord-005033-voi9gu0l.txt plain text: cord-005033-voi9gu0l.txt item: #35 of 549 id: cord-005327-bt7o8yxk author: Ahn, Insung title: Epidemiological comparisons of codon usage patterns among HIV-1 isolates from Asia, Europe, Africa and the Americas date: 2006-12-01 words: 4068 flesch: 44 summary: Using the same sequences, we classified the plots on the basis of their major subtypes, which included non-CRF and CRF subtypes, to determine the relationships between HIV-1 subtypes and their distributions in Asian countries (Figure 4) . As a result of geographical constraints, the distributions of these subtypes are so uneven that the differences in HIV-1 subtypes between countries can be used as a marker of epidemiological diversification. keywords: analysis; codon; countries; genes; patterns; sequences; subtype; usage cache: cord-005327-bt7o8yxk.txt plain text: cord-005327-bt7o8yxk.txt item: #36 of 549 id: cord-005335-u04cxiej author: Podder, C. N. title: Mathematical Analysis of a Model for Assessing the Impact of Antiretroviral Therapy, Voluntary Testing and Condom Use in Curtailing the Spread of HIV date: 2011-05-05 words: 5747 flesch: 56 summary: Individuals aware of their infection status progress through the various infection stages at the same rate (σ i ; i = 1, 2, 3) as those who are not (in other words, it is assumed that knowledge of HIV infection status does not alter the progression rate among untreated infected individuals). These notably include the staged-progression aspect, where a typical HIV-infected individual passes through several infection stages, being highly infectious during the pre-antibody phase (characterized by high viremia with over 10 million viral copies per ml), maintaining low infectivity during the asymptomatic phase and becoming highly infectious as s/he progresses toward AIDS (i.e., the AIDS stage of HIV infection) keywords: hiv; infection; model; stage; testing cache: cord-005335-u04cxiej.txt plain text: cord-005335-u04cxiej.txt item: #37 of 549 id: cord-005585-lc3fqhb0 author: Barbier, François title: Etiologies and outcome of acute respiratory failure in HIV-infected patients date: 2009-07-03 words: 4240 flesch: 40 summary: Pulmonary Complications of HIV infection Study Group Predictors of shortand long-term survival in HIV-infected patients admitted to the ICU Impact of HAART advent on admission patterns and survival in HIVinfected patients admitted to an intensive care unit Intensive care in patients with HIV infection in the era of highly active antiretroviral therapy Intensive care of patients with the acquired immunodeficiency syndrome: outcome and changing patterns of utilization Reappraisal of the aetiology and prognostic factors of severe acute respiratory failure in HIV patients Outcomes of intensive care for patients with human immunodeficiency virus infection Clinical course, prognostic factors, and outcome prediction for HIV patients in the ICU. Patients on ART were more likely to be admitted for bacterial pneumonia or noninfectious pulmonary disease than other patients (P = 0.02). keywords: arf; art; hiv; icu; patients; pcp; pneumonia cache: cord-005585-lc3fqhb0.txt plain text: cord-005585-lc3fqhb0.txt item: #38 of 549 id: cord-005833-fizh495d author: Baumschlager, D. title: Emotionale Befindlichkeit, kognitive Leistungsfähigkeit und Lebensqualität bei HIV-Patienten: Ergebnisse einer explorativen Untersuchung date: 2010-09-22 words: 3595 flesch: 38 summary: The structure of distress following trauma: Posttraumatic stress disorder, major depressive disorder and generalized anxiety disorder The two-factorial symptom structure of post-traumatic stress disorder: depression-avoidance and arousalanxiety Prevalence of post-traumatic stress disorder in patients with previous myocardial infarction consulting in general practice The prevalence of posttraumatic stress disorder in patients undergoing pulmonary rehabilitation and changes in PTSD symptoms following rehabilitation Impact of comorbid anxiety disorders on health-related quality of life among patients with major depressive disorder PTSD diagnoses, subsyndromal symptoms and comorbidities contribute to impairments for breast cancer survivors The relationship between quality of life and posttraumatic stress disorder or major depression for firefighters in Kaohsiung Posttraumatic stress disorder and health-related quality of life among a sample of treatment- and pension-seeking deployed Canadian Forces peacekeeping veterans The role of psychological and behavioral variables in quality of life and the experience of bodily pain among persons living with HIV The economic costs and health-related quality of life of people with HIV/AIDS in the Canary Islands HIV symptoms and health-related quality of life prior to initiation of HAART in a sample of HIV-Positive South Africans Health-related quality of life in bereaved HIV-positive adults: Relationships between HIV symptoms, grief, social support and Axis II indication A further investigation of health-related quality of life over time among men with HIV infection in the HAART era Neurocognitive impairment influences quality of life in HIVinfected patients receiving HAART The incidence of and risk factors for HIV-associated cognitive-motor complex among patients on HAART Neuropsychological impairment and the natural history of HIV-1 infection in Spanish subjects Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment Motor function and human immunodeficiency virus-associated cognitive impairment in a highly active antiretroviral therapy-era cohort Neurocognitive impairment in early HIV-positive individuals Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals Cognitive impairment in asymptomatic stages of HIV infection. Ein umfassenderes Verständnis von möglichen psychiatrischen Komplikationen im Gefolge der HIV-Erkrankung könnte die Basis für eine verbesserte biopsychosoziale Versorgung von HIV-Patienten darstellen. keywords: als; auf; bei; den; depression; der; die; disorder; eine; health; hiv; life; mit; patienten; patients; ptbs; ptss; quality; skt; stress; symptomatik; und; unserer; von; zwischen cache: cord-005833-fizh495d.txt plain text: cord-005833-fizh495d.txt item: #39 of 549 id: cord-005882-iodfgzjf author: Kaufmann, Stefan H E title: Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis date: 2005-04-05 words: 9677 flesch: 35 summary: Could AIDS and tuberculosis vaccines be given together? In contrast, experience with tuberculosis vaccine trials is marginal and currently only a few phase 1 trials have been initiated. keywords: aids; bcg; cd4; cd8; cells; efficacy; hiv; immunity; infection; mice; protection; responses; trials; tuberculosis; vaccination; vaccine; virus cache: cord-005882-iodfgzjf.txt plain text: cord-005882-iodfgzjf.txt item: #40 of 549 id: cord-006260-ux32zanj author: Sarkar, Paul title: Antimicrobial Agents are Societal Drugs: How Should This Influence Prescribing? date: 2012-09-17 words: 5351 flesch: 37 summary: [27] It is concerned with the trol measures to increase the useful lifespan of a overall effects of antimicrobial use from an ecologitherapy, and to allow time for new treatments and cal point of view. In the US, it has references, such as the Monthly Index of Medical been quoted that 50% of antibacterial use is in Specialties (MIMS) or the British National Formuhuman medicine, of which 80% is used in the comlary (BNF). keywords: antibacterials; antimicrobial; human; infections; medicine; patient; prescribing; problem; resistance; spectrum; treatment; use cache: cord-006260-ux32zanj.txt plain text: cord-006260-ux32zanj.txt item: #41 of 549 id: cord-006331-s2qf98lj author: Spiridonova, V. A. title: Molecular recognition elements: DNA/RNA-aptamers to proteins date: 2010-05-23 words: 7145 flesch: 57 summary: Now convincing evidence exists that aptamers are a new effective group of therapeutics, which may represent The scheme illustrating the SELEX method for preparation of DNA and RNA aptamers. The range of disso ciation constants characterizing binding of DNA and RNA aptamers to their protein targets varies from nanomolar to subnanomolar levels. keywords: activity; aptamer; binding; cells; complex; control; dna; hiv; human; library; molecules; protein; rna; rounds; selection; thrombin cache: cord-006331-s2qf98lj.txt plain text: cord-006331-s2qf98lj.txt item: #42 of 549 id: cord-006381-fsg9x8n7 author: Howard, O. M. Zack title: Chemokines as Molecular Targets for Therapeutic Intervention date: 1999 words: 6993 flesch: 32 summary: These results suggest that the suppression of chemokine receptor function could be achieved indirectly by agents that indirectly perturb the integrity of chemokine receptor signaling machinery. Libraries of large synthetic and natural peptide repertoires have been used to identify specific chemokine receptor antagonists. keywords: activity; antagonists; anti; binding; cell; chemokine; cxcr4; human; il-8; inhibition; mcp-1; peptide; rantes; receptor; sdf-1; type cache: cord-006381-fsg9x8n7.txt plain text: cord-006381-fsg9x8n7.txt item: #43 of 549 id: cord-006716-n371b91w author: Cone, A. M. title: Flumazenil reverses diazepam-induced neonatal apnoea and hypotonia date: 1993 words: 1622 flesch: 55 summary: Theoretically, HIV-1 testing in our data could be useful in one third of women (less and less important in SP of not IVDU HIV-I+ men, SP of IVDU HIV-I+ men, IVDU women) but effective counselling in two thirds. [2] did never seem to be enough to discourage IVDU women from pregnancy. keywords: hiv; ivdu; women cache: cord-006716-n371b91w.txt plain text: cord-006716-n371b91w.txt item: #44 of 549 id: cord-007188-tcq8lnwg author: Cunningham, Anthony L. title: Gastrointestinal Viral Infections in Homosexual Men Who were Symptomatic and Seropositive for Human Immunodeficiency Virus date: 1988-08-17 words: 2270 flesch: 39 summary: In this study we showed that patients with AIDS or ARC may present with acute diarrhea or exacerbations of chronic diarrhea and that in patients with symptomatic HIV infection and diarrhea, >50% excreted gastrointestinal viruses. Fecal specimens were collected early in the course of acute diarrhea, during exacerbations of chronic diarrhea, or on several occasions during persistent chronic diarrhea. keywords: aids; diarrhea; hiv; men; patients; viruses cache: cord-007188-tcq8lnwg.txt plain text: cord-007188-tcq8lnwg.txt item: #45 of 549 id: cord-007237-8y7218oj author: Manning, Ashleigh title: Comparison of Tissue Distribution, Persistence, and Molecular Epidemiology of Parvovirus B19 and Novel Human Parvoviruses PARV4 and Human Bocavirus date: 2007-05-01 words: 4531 flesch: 38 summary: New DNA viruses identified in patients with acute viral infection syndrome Cloning of a human parvovirus by molecular screening of respiratory tract samples Evidence of human coronavirus HKU1 and human bocavirus in Australian children Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Detection of human bocavirus in Japanese children with lower respiratory tract infections Bocavirus infection in hospitalized children The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Human bocavirus infection Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Frequent detection of bocavirus DNA in German children with respiratory tract infections Human bocavirus in French children Simmonds P. Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses Novel parvovirus and related variant in human plasma Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy A study of the role of parvovirus B19 in rheumatoid arthritis Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue Evidence for persistence of parvovirus B19 DNA in livers of adults High prevalence of viral genomes and multiple viral infections in the myocardium of adults with idiopathic left ventricular dysfunction Bioportfolio: lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue Persistent B19 infection in immunocompetent individuals: implications for transfusion safety Persistent parvovirus B19 infection without the development of chronic anemia in HIV-infected and -uninfected children: the Women and Infants Transmission Study Parvovirus B19 infection-persistence and genetic variation An immune control model for viral replication in the CNS during presymptomatic HIV infection Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis Identification of shared populations of human immunodeficiency virus type 1 infecting microglia and tissue macrophages outside the central nervous system Hedman K. Persistence of human parvovirus B19 in human tissues Prolonged activation of virusspecific CD8 + T cells after acute B19 infection Parvovirus B19-specific DNA in bone marrow from B19 arthropathy patients: evidence for B19 virus persistence Clinical and laboratory findings in immunocompetent patients with persistent parvovirus B19 DNA in bone marrow Presence and significance of human parvovirus B19 DNA in synovial membranes and bone marrow from patients with arthritis of unknown origin Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis Chronic human parvovirus B19 infection in rheumatic disease of childhood and adolescence Persistence of parvovirus B19 DNA in synovium of patients with haemophilic arthritis Parvovirus B19 and chronic arthritis-causal or casual association? Detection of adeno-associated virus 2 and parvovirus B19 in the human dorsolateral prefrontal cortex TTV viral load as a marker for immune reconstitution after initiation of HAART in HIV-infected patients Effect of immune modulation on TT virus (TTV) and TTV-like-mini-virus (TLMV) viremia TT virus infection: prevalence of elevated viraemia and arguments for the immune control of viral load Phylogenetic evidence for the rapid evolution of human B19 erythrovirus High rate of viral evolution associated with the emergence of carnivore parvovirus We are grateful to Frances Carnie for technical assistance with the brain and other autopsy tissue samples and to Gareth Hughes and Jill Douglas for providing plasma samples from HIV-infected and -uninfected individuals. keywords: aids; b19; dna; hiv; infection; parv4; samples; study; subjects cache: cord-007237-8y7218oj.txt plain text: cord-007237-8y7218oj.txt item: #46 of 549 id: cord-007890-bie1veti author: None title: ECC-4 Abstracts date: 2002-04-16 words: 86133 flesch: 45 summary: On the whole, E. coli showed an elevated sensitivity rate ( !/90% of tested strains) to nitrofurantoin, gentamicin, amikacin, and 2nd-and 3rd-generation cephalosporins, while only amoxicillin and piperacillin had a mean resistance rate !/30 % for M41L, D67N, K103N, M184V, L210W, T215YF, and for L10I, M36I, L63P, A71VT, L90M for P Inhibitors (PI). keywords: acid; activity; acute; administration; aeruginosa; agar; agents; aim; amoxicillin; analysis; antibiotic; antimicrobial; associated; aureus; b b; bacteria; beta; blood; candida; care; cases; cells; children; chronic; ciprofloxacin; clinical; coli; combination; concentrations; conclusion; control; cultures; data; days; department; diagnosis; disease; dna; dose; drug; effect; efficacy; erythromycin; esbl; fever; following; france; general; gentamicin; gram; group; haart; hcv; health; hepatitis; high; hiv; hospital; human; ifn; imipenem; incidence; infected; infection; influenza; institute; isolates; l b; laboratory; level; linezolid; mean; medical; medicine; methods; microbiology; mics; months; mrsa; nccls; negative; new; non; nosocomial; number; oral; patients; pcr; penicillin; period; plasma; pneumoniae; positive; presence; present; prevalence; pts; purpose; rate; resistance; results; risk; rna; samples; school; sensitivity; serum; spain; species; specific; spp; staphylococcus; strains; streptococcus; study; susceptibility; system; teicoplanin; tested; therapy; time; tissue; total; tract; treatment; university; urinary; urine; use; vancomycin; virus; vitro; years cache: cord-007890-bie1veti.txt plain text: cord-007890-bie1veti.txt item: #47 of 549 id: cord-008530-yni0poh9 author: Asensio, Valerie C. title: Chemokines and viral diseases of the central nervous system date: 2004-01-07 words: 15894 flesch: 34 summary: In a follow-up study by this group, examining chemokine receptor expression in SIV-AIDS encephalitis, the chemokine receptors CCR3, CCR5, CXCR3, and CXCR4 were found to be expressed by inflammatory cells within perivascular lesions (Westmoreland et al., 1998) . HIV-1 Tat induces monocyte chemoattractant protein-l-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors Chemokine receptor expression on resident and inflammatory cells in the brain of macaques with simian immunodeficiency virus encephalitis Rat LCRI: cloning and cellular distribution of a putative chemokine receptor in brain Neuroaxonal dystrophy in HTLV-l-associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains Molecular cloning of a novel human CC chemokine EBIl-ligand chemokine that is a specific functional ligand for EBI1, CCR7 Identification of single C motif-lflymphotactin receptor XCR1 Molecular cloning of a novel C-)~ or ~/-type chemokine, SCM-1 Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-l-associated dementia The chemokine receptor CCR8 is preferentially expressed in Th2 but not Thl cells Recent advances in chemokines and chemokine receptors Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development keywords: astrocytes; brain; ccr5; cells; chemokine; chemokine receptors; cns; cxcr4; disease; et al; expression; gene; hiv; human; infection; ip-10; leukocyte; mcp-1; mice; microglia; mip; neurons; protein; rantes; receptor; sdf-1; virus cache: cord-008530-yni0poh9.txt plain text: cord-008530-yni0poh9.txt item: #48 of 549 id: cord-008672-luoxomif author: Mwachari, C. title: Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya date: 2004-10-29 words: 3177 flesch: 44 summary: A significant association between colonization with adherent E. coli and chronic diarrhoea and wasting in AIDS patients has been demonstrated by Kotler et al., 19 who found such strains in 17% of study patients in the USA. ~ It is possible that novel agents remain to be characterized and associated with chronic diarrhoea and wasting in HIV patients, and HIV itself may be the cause of chronic diarrhoea in some patients. keywords: chronic; coli; culture; diarrhoea; hiv; patients; stool; study cache: cord-008672-luoxomif.txt plain text: cord-008672-luoxomif.txt item: #49 of 549 id: cord-009096-3c5t70an author: Frankish, Helen title: New WHO chief promises greater commitment to HIV/AIDS date: 2003-07-26 words: 1378 flesch: 41 summary: Together, learning from the past, we can change the future of global health. Mentored by senior WHO staff, these young professionals will form part of the next generation of international health leaders, he said. keywords: aids; general; health; lee cache: cord-009096-3c5t70an.txt plain text: cord-009096-3c5t70an.txt item: #50 of 549 id: cord-009269-6fs0f4b7 author: Youde, Jeremy title: Is universal access to antiretroviral drugs an emerging international norm? date: 2008-12-12 words: 10464 flesch: 46 summary: With the failure of Health for All by 2000, international health norms largely fell off the global agenda. Finally, I tie the specifics of universal ARV access' history to our broader understanding of norm evolution, showing how it illustrates the need to reconsider the factors that promote the acceptance of international norms. keywords: access; aids; arv; arv access; community; entrepreneurs; health; health care; norm; organization; rights; states; universal; universal arv; world cache: cord-009269-6fs0f4b7.txt plain text: cord-009269-6fs0f4b7.txt item: #51 of 549 id: cord-009388-k3exf8a4 author: Agarwal, Yash title: Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies date: 2020-04-10 words: 5870 flesch: 27 summary: The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs High activation and skewed T cell differentiation are associated with low IL-17A levels in a hu-PBL-NSG-SGM3 mouse model of HIV infection Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation HIV-1 infection and pathogenesis in a novel humanized mouse model Humanized Mice Engrafted With Human HSC Only or HSC and Thymus Support Comparable HIV-1 Replication, Immunopathology, and Responses to ART and Immune Therapy Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and CB-17-scid/bg immunodeficient mice Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells Humanized mice for immune system investigation: progress, promise and challenges Flt3L-mediated expansion of plasmacytoid dendritic cells Suppresses HIV infection in humanized mice RAG2(-/-)gamma(-/-)(c) In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell kick and kill in strategy for virus eradication Immunization of BLT humanized mice redirects T cell responses to Gag and reduces acute HIV-1 viremia In vivo excision of HIV-1 provirus by saCas9 and multiplex single-guide RNAs in animal models A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice Stem-cell based engineered immunity against HIV infection in the humanized mouse model A humanized mouse model generated using surplus neonatal tissue Cryptopatches are essential for the development of human GALT Generation of improved humanized mouse models for human infectious diseases Human immune system mice: current potential and limitations for translational research on human antibody responses Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rγnull mice The analysis of the functions of human B and T cells in humanized NOD/shi-scid/ cnull (NOG) mice (hu-HSC NOG mice) keywords: blt; cells; development; hiv; human; immunodeficient; infection; lymphoid; mice; model; mouse; system; tissues; transmission cache: cord-009388-k3exf8a4.txt plain text: cord-009388-k3exf8a4.txt item: #52 of 549 id: cord-009446-8keu2uay author: Kreer, Christoph title: Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies date: 2020-01-01 words: 6697 flesch: 32 summary: A platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires Potent and broad HIV-neutralizing antibodies in memory B cells and plasma Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses Recent progress in broadly neutralizing antibodies to HIV Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117 Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption Antibody 10-1074 suppresses viremia in HIV-1-infected individuals Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals Combination therapy with anti-HIV-1 antibodies maintains viral suppression Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus-associated acute liver failure Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires VH1-46 is the dominant immunoglobulin heavy chain gene segment in rotavirus-specific memory B cells expressing the intestinal homing receptor alpha4beta7 Immunodominance of the VH1-46 antibody gene segment in the primary repertoire of human rotavirus-specific B cells is reduced in the memory compartment through somatic mutation of nondominant clones Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoire Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine Rapid development of broadly influenza neutralizing antibodies through redundant mutations electrofusion and Epstein-Barr virus transformation for peripheral blood lymphocyte immortalization B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type B polysaccharide: Expression of canonical variable regions and their variants in vaccinated infants Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus Structures of Preferred Human IgV Genes-Based Protective Antibodies Identify How Conserved Residues Contact Diverse Antigens and Assign Source of Specificity to CDR3 Loop Variation cross-reactivity, and function of antibodies elicited by Zika virus infection Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1 Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120 Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies HIV-1 neutralizing antibodies: keywords: antibodies; antibody; antigen; bnabs; cell; development; gene; heavy; hiv-1; human; potent; receptor; repertoire; sequencing; single cache: cord-009446-8keu2uay.txt plain text: cord-009446-8keu2uay.txt item: #53 of 549 id: cord-009669-bcdjwpd1 author: Tsegaye, Theodros Solomon title: The multiple facets of HIV attachment to dendritic cell lectins date: 2010-09-20 words: 4866 flesch: 23 summary: The dendritic cellspecific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs HIV-1 trafficking to the dendritic cell-T-cell infectious synapse uses a pathway of tetraspanin sorting to the immunological synapse L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells Mycobacteria target DC-SIGN to suppress dendritic cell function Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/ CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway Structural basis for distinct ligandbinding and targeting properties of the receptors DC-SIGN and DC-SIGNR Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection Viral membrane fusion Glycosphingolipid composition of human immunodeficiency virus type 1 (HIV-1) particles is a crucial determinant for dendritic cell-mediated HIV-1 trans-infection Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1 Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue Maturation of blood-derived dendritic cells enhances human immunodeficiency virus type 1 capture and transmission Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo Significant virus replication in Langerhans cells following application of HIV to abraded skin: relevance to occupational transmission of HIV DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell-and mammalian cell-derived viruses DC-SIGN specifically recognizes Streptococcus pneumoniae serotypes 3 and 14 DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans-and cis-infection pathways cis Expression of DC-SIGN allows for more efficient entry of human and simian immunodeficiency viruses via CD4 and a coreceptor Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2 Dendritic cellspecific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals Recruitment of HIV and its receptors to dendritic cell-T cell junctions DC-SIGN enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells induces production of IFN-alpha and TNFalpha DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus Analysis of the interaction of Ebola virus glycoprotein with DC-SIGN (dendritic cellspecific intercellular adhesion molecule 3-grabbing nonintegrin) and its homologue DC-SIGNR DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer Dendritic-cellspecific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquitocell-derived dengue viruses Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes DC-SIGN is a receptor for human herpesvirus 8 on dendritic cells and macrophages Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN A variant in the CD209 promoter is associated with severity of dengue disease Structural requirements for multimerization of the pathogen receptor dendritic cell-specific ICAM3-grabbing non-integrin (CD209) on the cell surface HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells Leukocyte-specific protein 1 interacts with DC-SIGN and mediates transport of HIV to the proteasome in dendritic cells Langerhans cells and the cells of Langerhans cell histiocytosis do not express DC-SIGN DC-SIGN neck domain is a pH-sensor controlling oligomerization: SAXS and hydrodynamic studies of extracellular domain DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells Diversity of receptors binding HIV on dendritic cell subsets Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells Functionally distinct transmission of human immunodeficiency virus type 1 mediated by immature and mature dendritic cells CD4 coexpression regulates DC-SIGNmediated transmission of human immunodeficiency virus type 1 DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans Macropinocytosis and cytoskeleton contribute to dendritic cell-mediated HIV-1 transmission to CD4+ T cells Measles virus targets DC-SIGN to enhance dendritic cell infection Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1 Langerin is a natural barrier to HIV-1 transmission by Langerhans cells DC-SIGN and CD150 have distinct roles in transmission of measles virus from dendritic cells to T-lymphocytes Dendritic-cell interactions with HIV: infection and viral dissemination Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN HIV traffics through a specialized, surface-accessible intracellular compartment during trans-infection of T cells by mature dendritic cells We thank TF Schulz for support and the BMBF (grant 01KI 0703) and DFG (SFB 900) for funding. macrophagetropic human immunodeficiency viruses Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN Infection of dendritic cells (DCs), not DC-SIGN-mediated internalization of human immunodeficiency virus, is required for long-term transfer of virus to T cells The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells Plunder and stowaways: incorporation of cellular proteins by enveloped viruses In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells Dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN, CD209), a C-type surface lectin in human DCs, is a receptor for Leishmania amastigotes Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120 keywords: cells; dendritic; et al; hiv; infection; sign; trans; virus cache: cord-009669-bcdjwpd1.txt plain text: cord-009669-bcdjwpd1.txt item: #54 of 549 id: cord-009891-gqrhbhbn author: Rassool, G. Hussein title: Current issues and forthcoming events date: 2003-09-03 words: 3467 flesch: 45 summary: The report indicates that the key to better management of cancer pain is improved educational programmes and the development of dedicated pain management teams. The severity of cancer pain is often dependent on the type of cancer and stage of the disease. keywords: cancer; health; nursing; pain; patients; physicians; sars; treatment; vaccine cache: cord-009891-gqrhbhbn.txt plain text: cord-009891-gqrhbhbn.txt item: #55 of 549 id: cord-010001-u0d5jkp1 author: KOTWAL, GIRISH J. title: Anti‐HIV, Anti‐Poxvirus, and Anti‐SARS Activity of a Nontoxic, Acidic Plant Extract from the Trifollium Species Secomet‐V/anti‐Vac Suggests That It Contains a Novel Broad‐Spectrum Antiviral date: 2006-01-22 words: 2616 flesch: 46 summary: Plant extracts were diluted with phosphate-buffered saline. For the experiment, 12-well plates were used and in each plate the following was added: 1 ml RPMI-1640 medium (with Pen and Strep), 100 µl infected CCRF CEM (424.4 pg/ml), or 100 µl infected CEM 174 (20.3 pg/ml) and varying amounts of plant extract. keywords: antiviral; extract; hiv; plant; secomet; vaccinia; virus cache: cord-010001-u0d5jkp1.txt plain text: cord-010001-u0d5jkp1.txt item: #56 of 549 id: cord-010092-uftc8inx author: None title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 words: 233543 flesch: 50 summary: One central question is the need of individual NAT screening (ID) versus minipool NAT screening (MP) approaches to identify all relevant viremias in blood donors. 3A-S02-03 Background: The screening of blood donors and returning travelers from active transmission areas have highlighted the importance of diagnosis of acute arboviral infections. keywords: abo blood; addition; aims; allele; alloimmunization; analysis; anemia; anti; antibodies; antibody; antigen; apheresis; approach; assay; available; average; background; bacterial; bleeding; blood bank; blood cells; blood center; blood chimerism; blood collection; blood components; blood count; blood culture; blood demand; blood donation; blood donors; blood establishments; blood flow; blood group; blood grouping; blood loss; blood management; blood plasma; blood platelet; blood pressure; blood processing; blood products; blood results; blood safety; blood samples; blood services; blood supply; blood system; blood test; blood transfusion; blood type; blood units; blood volume; care; cases; cause; cell donors; cell transfusion; clinical; concentrates; concentration; conclusions; confirmed; content; control; cord blood; countries; criteria; cross; current; data; day; days; deferral; detection; difference; disease; dna; donations; donor samples; effect; events; evidence; exon; expression; factors; female; ferritin; flow; following; frequency; gel; gene; genotyping; group system; groups; hbv; hcv; health; hemoglobin; hev; history; hiv; hla; hospital; hospital blood; human; identification; igg; impact; incidence; increase; individuals; infection; information; international; iron; laboratory; levels; life; low; major; mean; median; medical; methods; min; ml blood; model; molecular; months; n =; national; need; negative; new; non; number; order; overall; p =; patients; pcr; pcs; period; phenotype; plasma; plasma donors; plasma transfusion; platelet; platelet donors; platelet transfusion; population; positive; post; potential; practice; presence; present; prevalence; procedure; process; production; quality; quality blood; range; rate; rbc blood; rbc transfusion; rbcs; reactive; red; reduced; repeat donors; research; results; rhd; rhd blood; risk; routine; screening; selection; sequencing; serum; significant; specific; staff; standard; status; storage; studies; study; summary; surgery; systems; tested; testing; tests; therapy; time donors; total; transfusion medicine; transfusion reactions; transfusion safety; transfusion service; transfusion therapy; transfusions; treated; treatment; typing; use; value; variant; versus; weak; women; years cache: cord-010092-uftc8inx.txt plain text: cord-010092-uftc8inx.txt item: #57 of 549 id: cord-010119-t1x9gknd author: None title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 words: 230433 flesch: 50 summary: Probability of occurrence of cannabis metabolites in blood donor samples is likely to be highly variable across donor centers and is largely dependent on blood donor demographics. OBRR, CBER, FDA Background/Case Studies: Extended molecular typing of a large number of blood donors can increase the likelihood of identifying donor red blood cells (RBCs) that match those of the recipient. keywords: abo; abo blood; acute; addition; alleles; alloimmunization; analysis; anemia; anti; antibodies; antibody; antigen; apheresis; approach; assay; average; background; bacterial; blood; blood bank; blood cells; blood center; blood collection; blood components; blood count; blood donation; blood donors; blood group; blood loss; blood management; blood order; blood ordering; blood products; blood safety; blood samples; blood screening; blood services; blood specimens; blood supplier; blood supply; blood system; blood testing; blood transfusion; blood type; blood units; blood volume; care; case studies; case study; cases; cd36; cell transfusion; center background; centers; change; clinical; collections; concentration; conclusion; control; cord blood; cost; count; cross; culture; current; data; days; decreased; detection; difference; disease; dna; donations; donor samples; dose; dtt; effect; emergency blood; evaluation; events; evidence; expression; factors; fda; female; ffp; finding; flow; following; frequency; fresh; gel; gene; genotyping; given; groups; hbv; hcv; health; hemoglobin; hemolysis; high; history; hiv; hla; hospital; hospital blood; hospital transfusion; hours; human; identification; igg; immucor; impact; implementation; improvement; incidence; increase; infection; information; initial; institution; inventory; iron; laboratory; levels; low; manual; mean; median; medical; method; mice; minutes; model; molecular; months; mtp; need; negative; new; non; normal; number; order; partial; pathogen; patients; pcr; performance; period; phase; phenotype; plasma; plasma samples; plasma transfusion; plasma units; platelet; platelet blood; platelet transfusion; platelet units; plt; plts; population; positive; post; post transfusion; potential; practice; pre; presence; present; prevalence; procedure; process; processing; program; protocol; quality; r blood; range; rate; rbc; rbc blood; rbc transfusion; rbc units; rbcs; reactive; reactivity; reagent; recipients; recovery; red; reduced; reduction; reference; report; response; results; review; rhd; risk; routine; screening; second; sensitivity; sequencing; serum; set; small; solution; specific; specificity; staff; standard; storage; study design; study period; survey; systems; table; technology; test results; testing; tests; therapy; time; titer; total; tpe; training; transfused; transfusion medicine; transfusion practice; transfusion protocol; transfusion reactions; transfusion results; transfusion service; transfusions; trauma; treatment; tube; typing; units; university; use; values; virus; wastage; wbc; weak; weeks; women; year; zika; zikv cache: cord-010119-t1x9gknd.txt plain text: cord-010119-t1x9gknd.txt item: #58 of 549 id: cord-010175-p2py9wau author: Winter, Harland title: GASTROINTESTINAL AND NUTRITIONAL PROBLEMS IN CHILDREN WITH IMMUNODEFICIENCY AND AIDS date: 1996-04-01 words: 4340 flesch: 25 summary: HeIicobacter pylari in children with acquired immunodeficiency syndrome Disseminated histoplasmosis as the acquired immunodeficiency syndrome-defining illness in an infant Intestinal parasites and HIV infection in Tanzanian children with chronic diarrhea Centers for Disease Control: Some of these same agents, such as the cytokine, tumor necrosis factor-a), are upregulated by HIV infection, affect intermediate metabolism, and cause malnutrition by increasing nutrient requirements. keywords: children; chronic; diarrhea; disease; enteric; function; gastrointestinal; hiv; immunodeficiency; infection; virus cache: cord-010175-p2py9wau.txt plain text: cord-010175-p2py9wau.txt item: #59 of 549 id: cord-010203-dt9m596i author: Hellen, Christopher U.T. title: Viral proteases as targets for chemotherapeutic intervention date: 2004-08-26 words: 3205 flesch: 26 summary: [11] compared the effectiveness as PR inhibitors of five different classes of dipeptide isosteres inserted into a consensus heptapeptide template. Knowledge of the strategies used in enhancing the potency and specificity of PR inhibitors, and in overcoming the inherent limitations of peptide-based inhibitors is likely to prove invaluable in the development of peptidemimetic inhibitors of other viral proteinases. keywords: cleavage; inhibitors; peptide; protease; proteinases; residues; structure; virus cache: cord-010203-dt9m596i.txt plain text: cord-010203-dt9m596i.txt item: #60 of 549 id: cord-010310-jqh75340 author: None title: Next Generation Technology for Epidemic Prevention and Control: Data-Driven Contact Tracking date: 2018-12-24 words: 6663 flesch: 37 summary: Collecting contact data from multi-views and analyzing contact patterns from multi-scale mobility interactions will be new directions in the future. Because of the high cost of tuberculosis vaccines, contact data can also aid in the determination of high-priority vaccinations. keywords: behaviors; contact; data; diseases; gps; group; individuals; information; interactions; methods; network; patterns; time; tracking cache: cord-010310-jqh75340.txt plain text: cord-010310-jqh75340.txt item: #61 of 549 id: cord-010499-yefxrj30 author: Yelverton, Elizabeth title: The function of a ribosomal frameshifting signal from human immunodeficiency virus‐1 in Escherichia coli date: 2006-10-27 words: 5905 flesch: 52 summary: Protein sequence analysis demonstrated the occurrence of two closeiy related frameshift mechanisms. Protein sequence analysis of the product indicates the occurrence of two siightiy different mechanisms of shifting. keywords: amino; codon; cycle; frameshifting; gallant; leucine; limitation; protein; reading; sequence; site; trna cache: cord-010499-yefxrj30.txt plain text: cord-010499-yefxrj30.txt item: #62 of 549 id: cord-010689-d2qn1doq author: Chehardoli, Gholamabbas title: Synthetic strategies, SAR studies, and computer modeling of indole 2 and 3-carboxamides as the strong enzyme inhibitors: a review date: 2020-05-12 words: 6318 flesch: 40 summary: In the route c, Silvestri et al. used BOP, triethylamine, DMF solvent, and corresponding amines in their research on the synthesis and evaluation of sulfonyl indole carboxamide derivatives. An interesting point in their proposed method was the use of isocyanate derivatives in the synthesis of indole carboxamides. keywords: activity; carboxamide; carboxamide derivatives; compound; derivatives; indole; inhibitors; renin; results; studies; synthesis cache: cord-010689-d2qn1doq.txt plain text: cord-010689-d2qn1doq.txt item: #63 of 549 id: cord-010699-mfe1oajn author: Suehiro, Tamy Taianne title: Cervical and oral human papillomavirus infection in women living with human immunodeficiency virus (HIV) and matched HIV-negative controls in Brazil date: 2020-05-11 words: 4484 flesch: 48 summary: Both HIV+ and HIV- women had a statistically higher prevalence of cervical HPV infection than oral infection. Both HIV+ and HIV-women had a statistically higher prevalence of cervical HPV infection than oral infection, including higher rates of hrHPV, lrHPV, universal HPV, and infection by multiple HPV types in cervical samples compared to oral ones, as shown in Table 2 . keywords: hiv+; hpv; human; infection; oral; prevalence; samples; women cache: cord-010699-mfe1oajn.txt plain text: cord-010699-mfe1oajn.txt item: #64 of 549 id: cord-010845-pakh49dy author: Isiguzo, Godsent title: Diagnosis and Management of Tuberculous Pericarditis: What Is New? date: 2020-01-15 words: 4109 flesch: 29 summary: The article provides hope for eradication of tuberculosis by the finding that M72/AS01E provided 54.0% protection for M. tuberculosis-infected adults against active pulmonary tuberculosis disease Prevalence of tuberculosis in post-mortem studies of HIV-infected adults and children in resource-limited settings: a systematic review and meta-analysis Tuberculous pericarditis: ten year experience with a prospective protocol for diagnosis and treatment Pericarditis-a five year study in the African Epidemiology of pericardial effusions at a large academic hospital in South Africa Global epidemiology of childhood tuberculosis The burden of presumed tuberculosis in hospitalized children in a resource-limited setting in Papua New Guinea: a prospective observational study Tuberculous pericardial effusions in children Tuberculous pericarditis in children: a review of 44 cases Tuberculous pericarditis Tuberculous pericarditis with and without HIV Characterization of the immunological features of tuberculous pericardial effusions in HIV positive and HIV negative patients in contrast with non-tuberculous effusions HIV-1 infection alters CD4+ memory T-cell phenotype at the site of disease in extrapulmonary tuberculosis Effect of prednisolone on inflammatory markers in pericardial tuberculosis: a pilot study A compartmentalized profibrotic immune response characterizes pericardial tuberculosis, irrespective of HIV-1 infection Ac-SDKP (N-acetyl-seryl-aspartyl-lysyl-proline) and galectin-3 levels in tuberculous pericardial effusion: implications for pathogenesis and prevention of pericardial constriction However, its non-superiority compared with older PCR is a drawback and calls for further investigations Comparison of PCR, culture, and histopathology for diagnosis of tuberculous pericarditis Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-gamma in a high burden setting: a prospective study Diagnostic Value of Interferon-gamma Release Assays on Pericardial Effusion for Diagnosis of Tuberculous Pericarditis The use of adenosine deaminase and interferongamma as diagnostic tools for tuberculous pericarditis Tuberculous pericardial effusion: analysis of commonly used diagnostic methods The authors highlight the role of interferon gamma as a stand-alone test to exclude or diagnose TBP, which is a potential step in rapid diagnosis Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis Poor penetration of antibiotics into pericardium in pericardial tuberculosis Triage strategy for urgent management of cardiac tamponade: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases A vanishing, tuberculous, pericardial effusion The management of tuberculous pericardial effusion: experience in 233 consecutive patients The causes, treatment, and outcome of acute heart failure in 1006 Africans from 9 countries Cardiac surgery capacity in sub-Saharan Africa: quo vadis? Controlled trial of prednisolone as adjuvant in treatment of tuberculous constrictive pericarditis in Transkei Management of tuberculous constrictive pericarditis and tuberculous pericardial effusion in Transkei: results at 10 years followup Interventions for treating tuberculous pericarditis Rationale and design of the Investigation of the Management of Pericarditis (IMPI) trial: a 2 x 2 factorial randomized double-blind multicenter trial of adjunctive prednisolone and Mycobacterium w immunotherapy in tuberculous pericarditis Colchicine for recurrent pericarditis (CORP): a randomized trial A prospective investigation into the effect of colchicine on tuberculous pericarditis keywords: constrictive; diagnosis; fluid; hiv; mtb; patients; pericarditis; study; tbp cache: cord-010845-pakh49dy.txt plain text: cord-010845-pakh49dy.txt item: #65 of 549 id: cord-011064-1d3v87km author: Roskin, Krishna M. title: Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth date: 2020-01-20 words: 7118 flesch: 34 summary: Here, insertion frequency in Ig genes correlated with SHM frequency and was decreased in all HIV-infected individuals compared to uninfected individuals, but deletion rates in IgG1 in bNAb individuals were higher, even than in uninfected individuals ( Supplementary Fig. 1e ). Clones with >19 amino acids in their CDR-H3s represented thousands of distinct lineages in each participant (mean of 8,548 for bNAb individuals, 7,540 for noNAb individuals and 7,891 for uninfected individuals). keywords: antibodies; antibody; bnab; cdr; cell; fig; frequencies; hiv; igg; individuals; nonab; sequences; shm; supplementary cache: cord-011064-1d3v87km.txt plain text: cord-011064-1d3v87km.txt item: #66 of 549 id: cord-011155-zraqyx78 author: Reif, Lindsey K. title: Interventions to Improve Antiretroviral Therapy Adherence Among Adolescents and Youth in Low- and Middle-Income Countries: A Systematic Review 2015–2019 date: 2020-03-09 words: 6267 flesch: 37 summary: results from a cluster randomized trial in Uganda Low HIV viral suppression rates following the intensive adherence counseling (IAC) program for children and adolescents with viral failure in public health facilities in Uganda Multi-month prescription of antiretroviral therapy amongst children and adolescents: experiences from the Baylor International Pediatric AIDS initiative (BIPAI) in six African countries Implementation and operational research: community-based adherence clubs for the management of stable antiretroviral therapy patients in Cape Town, South Africa: a cohort study The effectiveness and costeffectiveness of community-based support for adolescents receiving antiretroviral treatment: an operational research study in South Africa Effectiveness of community adolescent treatment supporters (CATS) interventions in improving linkage and retention in care, adherence to ART and psychosocial well-being: a randomised trial among adolescents living with HIV in rural Zimbabwe positive strategies to enhance problem-solving skills (STEPS): a pilot randomized, controlled trial of a multicomponent, technology-enhanced, customizable antiretroviral adherence intervention for HIV-infected adolescents and young adults Project ACCEPT: Evaluation of a group-based intervention to improve engagement in care for youth newly diagnosed with HIV Utility of mobile communication devices as a tool to improve adherence to antiretroviral treatment in HIV-infected children and young adults in Argentina Enhancing health among youth living with HIV using an iPhone game Adaptive antiretroviral therapy adherence interventions for youth living with HIV through text message and cell phone support with and without incentives: protocol for a sequential multiple assignment randomized trial (SMART) Evaluating a multi-component, community-based program to improve adherence and retention in care among adolescents living with HIV in Zimbabwe: study protocol for a cluster randomized controlled trial Positive STEPS -a randomized controlled efficacy trial of an adaptive intervention for strengthening adherence to antiretroviral HIV treatment among youth: study protocol Conditional economic incentives and motivational interviewing to improve adolescents' retention in HIV care and adherence to antiretroviral therapy in Southeast Nigeria: study protocol for a cluster randomised trial A combination intervention strategy to improve linkage to and retention in HIV care following diagnosis in Mozambique: A cluster-randomized study Effectiveness of a combination strategy for linkage and retention in adult HIV care in Swaziland: The Link4Health cluster randomized trial Longitudinal antiretroviral adherence among adolescents infected with human immunodeficiency virus Metropolitan Atlanta community adolescent rapid testing initiative: the impact of motivational interviewing and intensive case management on the psychosocial and clinical care outcomes of adolescents and young adults with HIV UNICEF Data Interventions for enhancing medication adherence How to detect and manage low patient compliance in chronic illness Effectiveness and content analysis of interventions to enhance medication adherence in hypertension: a systematic review and meta-analysis protocol Interventions for enhancing medication adherence Patient adherence to HIV medication regimens: a review of published and abstract reports Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons Correlates and predictors of adherence to highly active antiretroviral therapy: overview of published literature Medication adherence among HIV+ adults: effects of cognitive dysfunction and regimen complexity Everyone has a secret they keep close to their hearts': challenges faced by adolescents living with HIV infection at the Kenyan coast Social cognitive development during adolescence Examining the link between adolescent brain development and risk taking from a social-developmental perspective Determinants of adolescent pregnancy in sub-Saharan Africa: a systematic review Depression and stigma in high-risk youth living with HIV: a multi-site study Examining the relationship between psychological distress and adherence to anti-retroviral therapy among Ugandan adolescents living with HIV Psychosocial challenges and protective influences for socio-emotional coping of HIV+ adolescents in South Africa: a qualitative investigation Neurodevelopment in perinatally HIV-infected children: a concern for adolescence Impact of HIV severity on cognitive and adaptive functioning during childhood and adolescence Forget about forgetting: structural barriers and severe non-adherence to antiretroviral therapy Qualitative analysis of barriers and facilitators encountered by HIV patients in an ART adherence programme Patient-reported barriers to adherence to antiretroviral therapy: a systematic review and meta-analysis Facilitators and barriers to antiretroviral therapy adherence among adolescents in Ghana The effectiveness of counseling, material support and/or nutritional supplementation on improving adherence to anti-retroviral therapy and clinical outcomes among HIV patients: a systematic review of quantitative evidence protocol Viral suppression in adolescents on antiretroviral treatment: review of the literature and critical appraisal of methodological challenges Living situation affects adherence to combination antiretroviral therapy in HIV-infected adolescents in Rwanda: a qualitative study If I have nothing to eat, I get angry and push the pills bottle away from me: a qualitative study of patient determinants of adherence to antiretroviral therapy in the Democratic Republic of Congo Patientrelated risks for nonadherence to antiretroviral therapy among HIV-infected youth in the United States: a study of prevalence and interactions Contributions of disease severity, psychosocial factors, and cognition to behavioral functioning in US youth perinatally exposed to HIV System-level factors as predictors of adherence to clinical appointment schedules in antiretroviral therapy in Cambodia Factors associated with adherence to antiretroviral therapy among adolescents living with HIV/AIDS in low-and middle-income countries: a systematic review Barriers to HAART adherence among human immunodeficiency virus-infected adolescents Antiretroviral medication adherence among the REACH HIV-infected adolescent cohort in the USA Barriers to medication adherence in HIV-infected children and youth based on selfand caregiver report Mapping patient-identified barriers and facilitators to retention in HIV care and antiretroviral therapy adherence to Andersen's Behavioral Model Antiretroviral therapy adherence enhancing interventions for adolescents and young adults 13-24 years of age: a review of the evidence base Improving adherence to antiretroviral therapy for youth living with HIV/AIDS: a pilot study using personalized, interactive, daily text message reminders The use of cell phone support for non-adherent HIV-infected youth and young adults: an initial randomized and controlled intervention trial Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment The World by Income and Region. keywords: adherence; adolescents; art; care; hiv; interventions; studies; study; years; youth cache: cord-011155-zraqyx78.txt plain text: cord-011155-zraqyx78.txt item: #67 of 549 id: cord-011457-hqxybv1k author: Kirui, James title: Generation and validation of a highly sensitive bioluminescent HIV-1 reporter vector that simplifies measurement of virus release date: 2020-05-19 words: 5623 flesch: 40 summary: Another strategy that has been used to generate HIV-1 reporter virus involves inserting the reporter gene into the gene encoding the structural protein Gag, often between the matrix (MA) and capsid (CA) domains but in other regions of Gag as well [4] [5] [6] [7] . To enable simple and highly sensitive measurement of virus release from transfected cells, we generated HIV-1 reporter viruses in which Nanoluciferase (NanoLuc) was inserted between the MA and CA domains of Gag (Gag-iNanoLuc). keywords: activity; cells; gag; nanoluc; particle; pnl4; protein; release; reporter; vector; virus cache: cord-011457-hqxybv1k.txt plain text: cord-011457-hqxybv1k.txt item: #68 of 549 id: cord-011485-15wtv6bt author: Yang, Wenbo title: An immunoassay cassette with a handheld reader for HIV urine testing in point-of-care diagnostics date: 2020-05-21 words: 5639 flesch: 49 summary: The performance of the HIV immunoassay cassette was evaluated with HIV urine sample. Therefore, compared to traditional eye observation, the handheld optical reader is helpful to improve the detection sensitivity of HIV urine test with lateral flow strip. keywords: cassette; detection; fig; flow; hiv; module; reader; sample; strip; test; urine cache: cord-011485-15wtv6bt.txt plain text: cord-011485-15wtv6bt.txt item: #69 of 549 id: cord-011855-0vetk6jd author: Shayo, Elizabeth title: Ethical issues in intervention studies on the prevention and management of diabetes and hypertension in sub-Saharan Africa date: 2020-07-06 words: 2198 flesch: 49 summary: However, the standardisation would have inhibited HIV research in Africa and was opposed by global health researchers. Where Ministries of Health cannot achieve a reliable supply, even with the support of research programmes, then research in those settings may not be feasible. keywords: diabetes; health; hypertension; medicines; research cache: cord-011855-0vetk6jd.txt plain text: cord-011855-0vetk6jd.txt item: #70 of 549 id: cord-011903-zqt6vu6d author: Duby, Zoe title: “As a Young Pregnant Girl… The Challenges You Face”: Exploring the Intersection Between Mental Health and Sexual and Reproductive Health Amongst Adolescent Girls and Young Women in South Africa date: 2020-07-18 words: 7228 flesch: 40 summary: Child Care Pract Depression and its psychosocial risk factors in pregnant Kenyan adolescents: a cross-sectional study in a community health Centre of Nairobi It's better for me to drink, at least the stress is going away: perspectives on alcohol use during pregnancy among South African women attending drinking establishments Mapping a syndemic of psychosocial risks during pregnancy using network analysis The syndemic effects of intimate partner violence, HIV/AIDS, and substance abuse on depression among low-income urban women Understanding the role played by parents, culture and the school curriculum in socializing young women on sexual health issues in rural South African communities Associations between depressive symptoms, sexual behaviour and relationship characteristics: a prospective cohort study of young women and men in the Eastern Cape, South Africa Mental health and HIV sexual risk behaviour among University of Limpopo students Psychological and behavioral interventions to reduce HIV risk: evidence from a randomized control trial among orphaned and vulnerable adolescents in South Africa Anxiety and depression strongly associated with sexual risk behaviors among networks of young men in Dar es Salaam Depression and anxiety as risk factors for delayed careseeking behavior in human immunodeficiency virus-infected individuals in South Africa Qualitative data analysis for health services research: developing taxonomy, themes, and theory Thematic analysis: striving to meet the trustworthiness criteria Theme development in qualitative content analysis and thematic analysis Double disclosure bind: complexities of communicating an hiv diagnosis in the context of unintended pregnancy in Durban What is the relevance of mental health to HIV/AIDS care and treatment programs in developing countries? In addition to age-related factors and socio-economic factors, gender-related factors, including sexual and reproductive biology, also play a role in contributing to mental health risks. keywords: africa; agyw; depression; health; hiv; mental; pregnancy; risk; south; stress; support; years cache: cord-011903-zqt6vu6d.txt plain text: cord-011903-zqt6vu6d.txt item: #71 of 549 id: cord-012503-8rv2xof7 author: Levintow, Sara N. title: Estimating the Effect of Depression on HIV Transmission Risk Behaviors Among People Who Inject Drugs in Vietnam: A Causal Approach date: 2020-08-24 words: 5336 flesch: 37 summary: Global epidemiology of injecting drug use and HIV among people who inject drugs: a systematic review HIV prevention, treatment, and care services for people who inject drugs: a systematic review of global, regional, and national coverage The global HIV epidemics among people who inject drugs The HIV epidemic in Eastern Europe and Central Asia Drug use as a driver of HIV risks Estimating per-act HIV transmission risk A probability model for estimating the force of transmission of HIV infection and its application Scaling up HIV prevention efforts targeting people who inject drugs in Central Asia: a review of key challenges and ways forward Global, regional, and country-level coverage of interventions to prevent and manage HIV and hepatitis C among people who inject drugs: a systematic review The perfect storm: incarceration and the high-risk environment perpetuating transmission of HIV, hepatitis C virus, and tuberculosis in Eastern Europe and Central Asia Prevalence of depressive symptoms and associated factors among people who inject drugs in China Factors associated with symptoms of depression among injection drug users receiving antiretroviral treatment in Indonesia Depression and clinical progression in HIV-infected drug users treated with highly active antiretroviral therapy Frequency of and risk factors for depression among participants in the Swiss HIV Cohort Study (SHCS) Prevalence and predictors of depressive symptoms among HIV-positive men who inject drugs in Vietnam Longitudinal predictors of depressive symptoms among low income injection drug users Depression as an antecedent of frequency of intravenous drug use in an urban, nontreatment sample Depression severity and drug injection HIV risk behaviors Interrelation between psychiatric disorders and the prevention and treatment of HIV infection Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States Role of depression, stress, and trauma in HIV disease progression Depression in HIV infected patients: a review Psychiatric illness and virologic response in patients initiating highly active antiretroviral therapy Mortality under plausible interventions on antiretroviral treatment and depression in HIVinfected women: an application of the parametric g-formula Risk factors for HIV infection among men who have sex with men Depression, compulsive sexual behavior, and sexual risk-taking among urban young gay and bisexual men: the P18 cohort study Depression and oral FTC/TDF pre-exposure prophylaxis (PrEP) among men and transgender women who have sex with men (MSM/TGW) Depression, substance use and HIV risk in a probability sample of men who have sex with men A pilot study examining depressive symptoms, Internet use, and sexual risk behaviour among Asian men who have sex with men Mortality and HIV transmission among male Vietnamese injection drug users Regional differences between people who inject drugs in an HIV prevention trial integrating treatment and prevention (HPTN 074): a baseline analysis Are negative affective states associated with HIV sexual risk behaviors? Existing studies on depression and HIV transmission risk behaviors among PWID have suffered from several methodological limitations. keywords: behaviors; depressive; hiv; injection; pwid; risk; study; symptoms; time; transmission cache: cord-012503-8rv2xof7.txt plain text: cord-012503-8rv2xof7.txt item: #72 of 549 id: cord-013336-42thiglv author: Wang, Cheng title: Correlates of HIV self-testing among female sex workers in China: implications for expanding HIV screening date: 2020-10-22 words: 3641 flesch: 49 summary: This suggests HIV self-testing has the potential to increase the frequency of HIV testing among female sex workers, specifically among individuals not reached by provider-based strategies [11, 30] . Choose BMC Incarcerated sex workers and HIV prevention in China: social suffering and social justice countermeasures Syphilis self-testing: a nationwide pragmatic study among men who have sex with men in China Direct provision versus facility collection of HIV self-tests among female sex workers in Uganda: a cluster-randomized controlled health systems trial Promoting male partner HIV testing and safer sexual decision making through secondary distribution of self-tests by HIV-negative female sex workers and women receiving antenatal and post-partum care in Kenya: a cohort study HIV self-testing services for female sex workers, Malawi and Zimbabwe HIV self-testing among female sex workers in Zambia: a cluster randomized controlled trial Attitudes and acceptability on HIV self-testing among key populations: a literature review Scaling up HIV self-testing in sub-Saharan Africa: a review of technology, policy and evidence HIV self-testing in Pune, India: perspectives and recommendations of female sex workers and peer educators Global output of research on the health of international migrant workers from Acceptability and feasibility of a social entrepreneurship testing model to promote HIV self-testing and linkage to care among men who have sex with men HIV self-testing among online MSM in China: implications for expanding HIV testing among key populations keywords: china; female; hiv; self; sex; study; testing; workers cache: cord-013336-42thiglv.txt plain text: cord-013336-42thiglv.txt item: #73 of 549 id: cord-013442-kjfk7hq6 author: Muñoz-Laboy, Miguel title: “En la Lucha”: Strategies to Improve HIV Care for Puerto Ricans with Opioids Use Disorders date: 2020-10-30 words: 7648 flesch: 47 summary: Based on more than two decades of organizational experiences since the onset of the HIV epidemic in Philadelphia, and the review of the scientific literature in HIV care continuum outcomes, the leadership of both organizations and the intervention designers decided to establish Clínica Bienestar as guided by three principles: (1) Colocation of services for transnational groups to increase utilization of HIV services by minimizing unnecessary navigation through complex health care systems (primary care services, HIV services, substance use disorder treatment) while decreasing duplicative costs to achieve similar health outcomes (2) Integrated dual treatment approach (IDDT), a well-documented, effective approach to mental health and substance use treatments, expanded to include HIV primary care services to substance use and mental health services for Latinx with dual HIV and OUD diagnoses [28] keywords: bienestar; care; case; clínica; gloria; health; hiv; oud; philadelphia; puerto; rico; services; strategies; substance; tito; treatment; use; years cache: cord-013442-kjfk7hq6.txt plain text: cord-013442-kjfk7hq6.txt item: #74 of 549 id: cord-013481-3zwq67do author: Guo, Kejun title: Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 Pathogenesis date: 2020-10-16 words: 9586 flesch: 47 summary: Since IFNβ, and not IFNα, is upregulated during chronic HIV-1 infection in the gut, we compared core ISGs and IFNβ-specific ISGs from colon pinch biopsies of HIV-1-uninfected (n = 13) versus age- and gender-matched, antiretroviral-therapy naïve persons with HIV-1 (PWH; n = 19). In fact, IFNAR blockade during chronic HIV-1 infection in humanized mice restored immune function, leading to better HIV-1 control keywords: cd4; cell; chronic; core; differences; expression; fig; genes; gut; ifnα; ifnα14; ifnβ; infection; interferon; isgs; levels; subtypes; table cache: cord-013481-3zwq67do.txt plain text: cord-013481-3zwq67do.txt item: #75 of 549 id: cord-014608-g3p19coe author: None title: Pneumococcal colonization and carriage date: 2014-12-01 words: 21723 flesch: 46 summary: Mar 9-13;3:1-286 †AziR, azithromycin-resistant Spn strain(s) as % children (80% of resistant strains had MIC≥16mg/L); *Vaccine serotypes in bold, AziR serotypes in italics. Adherence to standard methods will reduce variability when conducting pneumococcal carriage studies. keywords: background; carriage; children; colonization; conclusion; conjugate; disease; hiv; infected; introduction; isolates; methods; months; nasopharyngeal; non; pcv13; pcv7; pneumococcal; pneumoniae; prevalence; results; serotypes; streptococcus; study; swabs; vaccine; years cache: cord-014608-g3p19coe.txt plain text: cord-014608-g3p19coe.txt item: #76 of 549 id: cord-015324-y44sfr0c author: None title: Scientific Programme date: 2007-09-01 words: 197844 flesch: 49 summary: In the group I, consisted of 63 infants (35 males and 28 females) PCD increased during the time in 3,2% infants, remained unchanged in 11,1%, decreased in 14,3%, and disappeared in 71,4% patients. There was no significant difference between renal transplant patients and healthy controls in genotype distribution of allelic frequencies of IL-6, FAS and MCP-1 polymorphisms. keywords: abnormalities; according; acid; activity; acute; adult patients; adults; age; aim; analysis; anti; associated; background; baseline; biopsy; blood; body; bone; boys; calcium; cases; cause; cells; changes; childhood; children; chronic; ckd; clinical; complete; conclusion; control; control group; correlation; course; creatinine; crf patients; csa; damage; data; day; days; development; diagnosis; dialysis; dialysis patients; difference; disease; dose; duration; dysfunction; effect; elevated; end; esrd; examination; excretion; expression; factor; failure; family; findings; follow; fsgs; function; gene; gfr; girls; glomerular; glomerulonephritis; grade; graft; group; growth; hd patients; hematuria; history; hospital; human; hus; hypertension; iga; incidence; increase; infants; infection; initial; injury; kidney; kidney disease; levels; male; mean; median; mesangial; metabolic; methods; mice; min/1.73; mmf; months; mrna; mutations; negative; nephritis; nephrology; nephropathy; nephrotic; non; normal; number; objective; onset; outcome; p<0.001; p<0.05; parameters; patients; pcr; pediatric; period; peritoneal; plasma; population; positive; post; prednisone; presence; present; pressure; primary; progression; proteinuria; pth; range; rare; rate; ratio; rats; reflux; rejection; relapse; remission; renal; renal biopsy; renal transplantation; report; response; results; risk; role; second; serum; severe; specific; srns; stage; steroid; studies; study; study group; survival; symptoms; syndrome; system; tacrolimus; term; test; therapy; time; total; tract; transplant patients; transplantation; treated; treatment; tubular; type; ultrasound; urinary; urine; uti; values; vs.; vur; vur patients; weeks; weight; years; yrs cache: cord-015324-y44sfr0c.txt plain text: cord-015324-y44sfr0c.txt item: #77 of 549 id: cord-015372-76xvzvdg author: None title: National scientific medical meeting 1996 abstracts date: 1996 words: 36628 flesch: 50 summary: Control patients were enrolled who had no clinical evidence of rheumatological disease, A salivary sample was collected and examined by light microscopy. Drug induced photosensitivity may look identical clinically, have a similar history and patients with CAD may be treated with potentially photosensitising drugs. keywords: acid; activity; age; aim; analysis; antibodies; blood; bone; care; cases; cells; children; controls; data; day; difference; disease; drug; expression; females; findings; following; group; hiv; hospital; incidence; increase; infection; irish; levels; males; mean; months; negative; number; pain; patients; pcr; period; population; positive; present; range; rate; response; results; risk; samples; serum; skin; studies; study; subjects; test; therapy; time; total; treatment; type; use; virus; years cache: cord-015372-76xvzvdg.txt plain text: cord-015372-76xvzvdg.txt item: #78 of 549 id: cord-015376-z739ifu5 author: Savarino, Andrea title: Potential therapies for coronaviruses date: 2006-08-31 words: 6367 flesch: 46 summary: A review providing the immunological grounds for a potential use of chloroquine in the clinical management of SARS Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine This article describes the first experiments showing an anti-SARS-CoV effect of chloroquine Chloroquine is a potent inhibitor of SARS coronavirus infection and spread This research article provides the mechanisms of SARS-CoV inhibition by chloroquine Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque The coronavirus replicase Binding site-based classification of coronaviral papain-like proteases Virus-encoded proteinases and proteolytic processing in the Nidovirales Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins Viral RNA replication in association with cellular membranes Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors A novel auto-cleavage assay for studying mutational effects of the active site of severe acute respiratory syndrome coronavirus 3C-like protease Medical treatment of viral pneumonia including SARS in immunocompetent adult Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Severe acute respiratory syndrome-related coronavirus is inhibited by IFN-α Expanding the frontiers of existing antiviral drugs: possible effects of HIV-1 protease inhibitors against SARS and avian influenza This paper reviews the information available on the use of HIV-1 protease inhibitors against SARS-CoV and provides the results of a molecular docking study Identifying inhibitors of the SARS coronavirus proteinase This bioinformatic analysis of drug/enzyme docking provides interesting insights on the use of HIV-1 protease inhibitors as lead compounds for development of 3Clpro inhibitors Old drugs as lead compounds for a new disease? keywords: 3clpro; chloroquine; compounds; coronavirus; cov; drug; effects; inhibitors; protease; replication; rna; sars; use cache: cord-015376-z739ifu5.txt plain text: cord-015376-z739ifu5.txt item: #79 of 549 id: cord-015831-s78omm53 author: Kaufman, Joan title: Civil Society Involvement in National HIV/AIDS Programs date: 2019-05-20 words: 6398 flesch: 45 summary: An important group working on the frontlines of stigma against PLWH has been AIDS Care China. AIDS Care China and its founder and leader, Thomas Cai, received the Red Ribbon Award from the UN for work supporting care and treatment of PLWH. keywords: aids; china; chinese; funding; global; government; groups; hiv; ngos; prevention; response; role; support cache: cord-015831-s78omm53.txt plain text: cord-015831-s78omm53.txt item: #80 of 549 id: cord-015936-4fwkf8fn author: None title: SUBJECT INDEX, volumes 123-130 date: 2005-11-04 words: 69 flesch: 15 summary: key: cord-015936-4fwkf8fn authors: nan title: SUBJECT INDEX, volumes 123-130 date: 2005-11-04 journal: J Virol Methods DOI: 10.1016/s0166-0934(05)00346-0 sha: doc_id: 15936 cord_uid: 4fwkf8fn nan HIV; 2 LTR circles; New marker (125) 11 HIV antigen/antibody combined assay; HIV; Serology; HIV-1 p24 antigen assay (127) (127) (128) (128) 67 Yeast expression; Pichia pastoris; SARS-CoV; N protein (130) 83 enzyme analysis; Flaviviruses; RT-PCR keywords: hiv cache: cord-015936-4fwkf8fn.txt plain text: cord-015936-4fwkf8fn.txt item: #81 of 549 id: cord-015958-68dmza13 author: Ceccherini-Nelli, Luca title: Globalizzazione in medicina: l’emergenza HIV date: 2007 words: 5163 flesch: 39 summary: La presenza del virus e di numerose varianti in aree non contigue indica una diffusione precedente alla sua identificazione. e più di 160 persone sono risultate infette, con più del 50% di mortalità keywords: aids; alla; anche; anni; causa; che; con; dei; dell'infezione; della; diffusione; dove; famiglia; fra; hiv; infetti; infezioni; milioni; negli; nei; nel; nelle; non; nuovi; paesi; persone; più; quali; sia; sono; specie; stati; sviluppo; trasmissione; trattamento; una; virale; virus cache: cord-015958-68dmza13.txt plain text: cord-015958-68dmza13.txt item: #82 of 549 id: cord-016041-427mbaqc author: Hengge, Ulrich R. title: Gentherapie date: 2008 words: 7333 flesch: 34 summary: gemeinsam von der Deutschen Gesellschaft für Die Transduktionsraten von DC und die Expressionsdauer wurden in Abhängigkeit vom verwendeten Vektor untersucht. keywords: 2004; aav; als; auch; auf; bei; bzw; cells; das; dass; dem; der; des; die; diese; dna; durch; eine; eingesetzt; et al; expression; für; gegen; gene; gentherapie; hiv; hiv-1; ist; melanoma; mit; nach; nicht; oder; patienten; rna; scid; sich; sind; therapy; transfer; tumor; und; vakzinierung; vectors; vektoren; virus; von; war; werden; wurde; zeigte; zellen; zum; zur cache: cord-016041-427mbaqc.txt plain text: cord-016041-427mbaqc.txt item: #83 of 549 id: cord-016075-ind62t53 author: Hwang, Stephen W. title: Homeless People date: 2005 words: 10407 flesch: 40 summary: Homeless people with schizophrenia receive less detailed physical examinations, fewer primary care visits, and less preventive health services than homeless people with major depression . Competing priorities as a barrier to medical care among homeless adults in Los Angeles Chronically homeless women's perceived deterrents to contraception A national survey of the oral health status of homeless veterans Panhandling for change in Canadian law Prevalence and correlates of survival sex among runaway and homeless youth Substance use among runaway and homeless youth in three national samples Youth and familial substance use's association with suicide attempts among runaway and homeless youth Pregnancy among three national samples of runaway and homeless youth Inappropriate emergency department visits and use of the Health Care for the Homeless Program services by Homeless adults in the northeastern United States The limits of neighbourhood empowerment: Gentrification, resistance, and burn-out in Kitsilano Health Care for the Homeless Information Resource Center Two genealogies of supported housing and their implications for outcome assessment Mortality among men using homeless shelters in Toronto Barriers to appropriate diabetes management among homeless people in Toronto Homelessness and health Causes of death in homeless adults in Boston The Homeless Prevalence of tuberculosis infection among homeless young people in central and eastern Sydney Divided We Sprawl Slowing the revolving door: stabilization programs reduce homeless persons' substance use after detoxification Homeless youth and their exposure to and involvement in violence while living on the streets Housing and health: time again for public health action Applying cluster analysis to test a typology of homelessness by pattern of shelter utilization: results from the analysis of administrative data keywords: care; cities; city; et al; health; health care; high; homeless; homelessness; housing; people; population; prevalence; risk; shelter; street; urban; use cache: cord-016075-ind62t53.txt plain text: cord-016075-ind62t53.txt item: #84 of 549 id: cord-016255-kkko1xne author: van der Meer, J.T.M. title: 14 Intravasale infecties en sepsis date: 2011 words: 7440 flesch: 50 summary: Een goede indruk van de relevantie van een CMV-infectie is in die gevallen te verkrijgen door het meten van de hoeveelheid viraal DNA in bloed of plasma. Een bespreking van de aangrijpingspunten van antivirale therapie is te vinden in hoofdstuk 1 (paragraaf 1.7.2). keywords: aantal; acute; als; antistoffen; bij; bloed; cd4; cellen; cmv; dan; dat; deze; die; dit; door; ebv; een; fase; gepaard; gevolg; geïnfecteerde; het; hiv; hiv-2; hoeveelheid; hoofdstuk; infectie; kan; komt; kunnen; lymfadenopathie; maar; meer; men; niet; ook; patiënten; plasma; primaire; tegen; tijdens; tot; transmissie; uit; van; virale; virus; virussen; vooral; werd; worden; wordt; zich; ziekte; zijn; zoals cache: cord-016255-kkko1xne.txt plain text: cord-016255-kkko1xne.txt item: #85 of 549 id: cord-016283-b6yywn9f author: Hasan, Ashfaq title: Clinical Aspects and Principles of Management of Tuberculosis date: 2019-08-07 words: 6934 flesch: 41 summary: Disseminated TB Disseminated TB should always raise suspicion for an accompanying immune deficiency such as HIV disease. In a recent study done on TB patients requiring ICU admission, mortality was 72.5% (Tatar et al. 2018 ). keywords: agents; children; diagnosis; disease; drug; hiv; mdr; patients; resistance; rifampicin; therapy; treatment; tuberculosis cache: cord-016283-b6yywn9f.txt plain text: cord-016283-b6yywn9f.txt item: #86 of 549 id: cord-016313-n4ewq0pt author: Baranyi, Lajos title: Advances in Lentiviral Vector-based Cell Therapy with Mesenchymal Stem Cells date: 2012-09-27 words: 20593 flesch: 29 summary: However, much more needs to be known about the normal differentiation and functioning of the airway's basal cells and the differentiation and lineages of stem cells to have more ef fi cient treatment options both for gene therapy and for stem cell therapy [ 207 ] . Alas, the dif fi culties in research are faithfully re fl ected in the confusion in the nomenclature used for describing and classifying stem cells, including the classes of stem cells of mesodermal origin. keywords: alpha; beta; bone; cell therapy; ciency; cient; delivery; differentiation; disease; ef fi; endothelial; expression; fi c; fi cient; gene; gene therapy; human; lentiviral; mesenchymal; mesenchymal stem; mice; model; mscs; novel; potential; protein; signi; signi fi; speci; speci fi; stem cells; therapy; tissue; transduction; transfer; transplantation; use; vector; virus; vivo cache: cord-016313-n4ewq0pt.txt plain text: cord-016313-n4ewq0pt.txt item: #87 of 549 id: cord-016472-jj7fqcen author: Freudenberg, Nicholas title: Health Research Behind Bars: A Brief Guide to Research in Jails and Prisons date: 2007 words: 7503 flesch: 27 summary: Funders who have provided significant support to correctional health research include public agencies such as the National Institutes of Drug Abuse, Alcohol Abuse and Alcoholism, Mental Health, and Allergy and Infectious Diseases, the Centers for Disease Control and Prevention, the National Institute of Justice, and some state and local governments. â�¢ What level of individual or population benefits in correctional health research balances potential risks? keywords: health; hiv; incarceration; inmates; jail; justice; officials; populations; prison; public; research; researchers; services; studies; study cache: cord-016472-jj7fqcen.txt plain text: cord-016472-jj7fqcen.txt item: #88 of 549 id: cord-016690-3gsq724l author: Li, Hongjun title: HIV/AIDS Related Respiratory Diseases date: 2013-09-30 words: 26773 flesch: 44 summary: Pathogens of HIV related pulmonary infections include parasites, fungi, mycobacteria, viruses, bacteria and toxoplasma gondii. In this section, the clinical manifestations and imaging findings of HIV related pulmonary infections are analyzed and discussed, which provide effective diagnosis basis, so as to reduce the incidence of HIV-related pulmonary infections. keywords: aids; aids patients; bronchial; cancer; cases; cd4; cell; changes; chest; cough; count; diagnosis; fever; hiv; imaging; infection; infi; lesions; lung; manifestations; nodules; parenchymal; patients; pneumonia; pulmonary; ray; shadows; symptoms; tuberculosis; type cache: cord-016690-3gsq724l.txt plain text: cord-016690-3gsq724l.txt item: #89 of 549 id: cord-016704-99v4brjf author: Nicholson, Felicity title: Infectious Diseases: The Role of the Forensic Physician date: 2005 words: 14642 flesch: 55 summary: In 1998, 56% of reported cases were from people born outside the United Kingdom and 3% were associated with HIV infection (70, 71) . Clusters of skin infections with MRSA have been reported among injecting drug users (IDUs) since 1981 in America (45, 46) , and more recently, similar strains have been found in the United Kingdom in IDUs in the community (47) . keywords: blood; cases; contact; detainee; disease; exposure; gloves; hbv; health; hepatitis; hiv; infection; kingdom; people; risk; skin; staff; transmission; treatment; united; vaccine; years cache: cord-016704-99v4brjf.txt plain text: cord-016704-99v4brjf.txt item: #90 of 549 id: cord-016718-cxn1ewfw author: Anderson, Virginia title: Performing Interventions: The Politics and Theatre of China’s AIDS Crisis in the Early Twenty-First Century date: 2017-11-08 words: 5864 flesch: 55 summary: [It] explores the theme of AIDS from social, family, ethic [sic] and moral perspectives, cautioning people to keep away from AIDS and calling for social concern for AIDS patients' (State Council 2001) . Documentaries such as The Blood of Yingzhou District (Lennon and Yang 2007) , The Epic of Central Plains (Ai 2007), Together (Zhao 2010) Understanding HIV-Related Stigma and Discrimination in a Blameless A Joint Assessment Report of HIV/AIDS Prevention, Treatment and Care in China The Main Melody Campaign in Chinese Spoken Drama 26 Companies of the Global Business Coalition on HIV/AIDS (GBC) Announce Immediate Commitments to Fight AIDS in China HIV and AIDS Stigma and Discrimination in China: keywords: aids; china; epidemic; government; hiv; people; ping; play; stigma; theatre; tian; xiao; zhao cache: cord-016718-cxn1ewfw.txt plain text: cord-016718-cxn1ewfw.txt item: #91 of 549 id: cord-016829-37i1bn9m author: None title: Bilateral and Multilateral Financing of HIV/AIDS Programs: The World Bank, the International Monetary Fund, the Global Fund, Bilateral Donors and the Private Sector date: 2008 words: 13456 flesch: 43 summary: With Product RED, the world's leading companies made a commitment to channel a portion of their profits from sales of speciallydesigned products to the Global Fund to support AIDS programs for women and children in Africa. These lapses in political leadership highlight the need to incorporate political leadership into AIDS programs that are funded by multilateral, bilateral and private sector donors. keywords: aids; aids programs; countries; development; donors; evaluation; foundation; fund; funding; global; global fund; government; health; hiv; imf; international; national; prevention; programs; response; sector; treatment; world bank cache: cord-016829-37i1bn9m.txt plain text: cord-016829-37i1bn9m.txt item: #92 of 549 id: cord-017012-yl0vanuh author: Herberg, Jethro title: Infectious Diseases and the Kidney date: 2009 words: 23989 flesch: 30 summary: Bacterial infections associated with renal disease and the likely mechanisms causing renal dysfunction are shown in > Impaired renal function is a common occurrence in systemic sepsis (1) . The group A streptococci (GAS) are a major worldwide cause of renal disease, usually as poststreptococcal nephritis. keywords: acute; bkv; cases; cause; cells; children; chronic; diagnosis; disease; evidence; failure; features; fever; glomerular; hbv; hepatitis; hiv; illness; immune; infection; involvement; kidney; nephritis; nephropathy; patients; present; proteinuria; renal; shock; syndrome; therapy; treatment; urine; virus cache: cord-017012-yl0vanuh.txt plain text: cord-017012-yl0vanuh.txt item: #93 of 549 id: cord-017070-05vlz5dn author: Dimitrov, Dimiter S. title: Human Monoclonal Antibodies Against HIV and Emerging Viruses date: 2008 words: 6678 flesch: 27 summary: The prospects for vaccines against HIV-1: more than a field of long-term nonprogression? HIV vaccine design and the neutralizing antibody problem Antibody-based inhibitors of HIV infection Antibody neutralization and escape by HIV-1 Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1 Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1 Broadly crossreactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes Identifying epitopes of HIV-1 that induce protective antibodies Selection of a novel gp41-specific HIV-1 neutralizing human antibody by competitive antigen panning Virus isolates during acute and chronic human immunodeficiency virus type 1 infection show distinct patterns of sensitivity to entry inhibitors A novel coronavirus associated with severe acute respiratory syndrome Coronavirus as a possible cause of severe acute respiratory syndrome Identification of a novel coronavirus in patients with severe acute respiratory syndrome SARS-associated coronavirus Chronological evolution of IgM, IgA, IgG and neutralisation antibodies after infection with SARS-associated coronavirus Neutralizing antibodies in patients with severe acute respiratory syndrome-associated coronavirus infection Antibody responses against SARS-coronavirus and its nucleocaspid in SARS patients Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein SARS corona virus peptides recognized by antibodies in the sera of convalescent cases S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Treating severe acute respiratory syndrome with hyperimmune globulins SARS: what have we learned? Treating severe acute respiratory syndrome with hyperimmune globulins Human monoclonal antibodies to the S glycoprotein and related proteins as potential therapeutics for SARS An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Molecular and biological characterization of human monoclonal antibodies binding to the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody keywords: activity; antibodies; antibody; binding; coronavirus; cov; hiv; hmabs; human; infection; sars; syndrome; virus cache: cord-017070-05vlz5dn.txt plain text: cord-017070-05vlz5dn.txt item: #94 of 549 id: cord-017227-66dx2dkv author: Humphreys, Hilary title: Immunocompromised Patients date: 2012-08-21 words: 4903 flesch: 33 summary: Clearly, the change in prognosis of HIV with HAART has led to a shift in management such that HIV patients are offered maximal treatment, including full ICU support, organ transplantation in the appropriate circumstances, or chemotherapy if needed. A thorough discussion of the management of HIV patients is beyond the scope of this book. keywords: aspergillosis; cancer; disease; hiv; icu; infection; neutrophil; patients; pcp; transplantation; treatment cache: cord-017227-66dx2dkv.txt plain text: cord-017227-66dx2dkv.txt item: #95 of 549 id: cord-017412-1avevzya author: Losada, Liliana title: The Human Lung Microbiome date: 2010-10-11 words: 10016 flesch: 28 summary: Lastly, Wu et al. have provided evidence to suggest that viral infections have a causal role in asthma initiation and development where they show that viral infection during the first 4 months of age is strongly correlated with the development of asthma by age 5 (Wu et al., 2008) . To test this hypothesis, 16S rRNA sequence analysis was performed on BAL samples from 42 subjects, 28 CF patients, and 14 other disease controls (Harris et al., 2007) . keywords: airway; asthma; bacteria; cells; chronic; colonization; copd; development; disease; et al; exacerbations; fungal; hiv; human; infections; lung; microbiome; patients; species; studies; study cache: cord-017412-1avevzya.txt plain text: cord-017412-1avevzya.txt item: #96 of 549 id: cord-017439-0c6ohmmg author: Hughes-Oliver, Jacqueline M. title: Pooling Experiments for Blood Screening and Drug Discovery date: 2006 words: 7874 flesch: 45 summary: On the information and accuracy of pooled testing in estimating prevalence of a rare disease: Application to HIV screening Regression models for disease prevalence with diagnostic tests on pools of serum samples Pooling sera to reduce the cost of HIV surveillance: A feasibility study in a rural Kenyan district Pooled testing for HIV screening: Capturing the dilution effect Recommendations for testing for HIV antibody on serum pool. Gastwirth and Johnson (1994) , who were also concerned with error rates for labeling individuals assuming imperfect testing, proposed a back-end retesting stage where pooled testing is used to rescreen a subset of individuals who were declared inactive from first-stage pooled testing. keywords: blood; discovery; drug; et al; individuals; number; pooling; pools; screening; sero; testing cache: cord-017439-0c6ohmmg.txt plain text: cord-017439-0c6ohmmg.txt item: #97 of 549 id: cord-017506-t86v3zw3 author: Knox, Tamsin A. title: Alcohol, HIV/AIDS, and Liver Disease date: 2012-04-27 words: 7651 flesch: 27 summary: Alcohol use, in moderate or hazardous amounts, has been associated with increased acquisition of HIV infection, progression of HIV infection, deleterious effects on HIV treatment, and acceleration in the comorbidities of HIV infection [4–9]. Alcohol use, in moderate or hazardous amounts, has been associated with increased acquisition of HIV infection, progression of HIV infection, deleterious effects on HIV treatment, and acceleration in the comorbidities of HIV infection [4] [5] [6] [7] [8] [9] . keywords: adherence; alcohol; chronic; disease; drinking; hepatitis; hiv; infection; patients; persons; risk; study; use; virus cache: cord-017506-t86v3zw3.txt plain text: cord-017506-t86v3zw3.txt item: #98 of 549 id: cord-017600-4e7mw041 author: Pfister, H. -W. title: Infektionen date: 2008 words: 12958 flesch: 35 summary: Die akute Schmerzsymptomatik der klassischen Trias der Neuroborreliose bildet sich sehr rasch zurück, bestehende Paresen brauchen sehr viel länger zur Rückbildung. Stereotaktische oder off ene Biopsien einerseits, die Implantation eines ventrikuloatrialen oder ventrikuloperitonealen Shunts bei Hydrozephalus andererseits sowie die Implantation eines Rickham-oder Ommaya-Reservoirs zur intraventrikulären Medikamentenapplikation sind im keywords: aber; aids; akuten; als; auch; auf; auft; aus; bakteriellen; bei; bereits; besteht; bis; bzw; cerebral; das; dass; defi; dem; der; des; diagnose; die; diff; durch; eine; entzündungen; enzephalitis; erapie; erkrankungen; erreger; fälle; für; hiv; hydrozephalus; häufi; infektion; insbesondere; intrakraniellen; ist; kann; klinischen; kommt; komplikationen; können; liquor; läsionen; malaria; meist; meningitis; mit; mittels; mrt; muss; myelitis; nach; nachweis; neben; neurologische; nicht; nur; oder; patienten; patients; pcr; pleozytose; pml; prognose; sche; sehr; selten; sich; sie; sind; sollte; sowie; spezifi; spinalen; tab; treatment; und; unter; verdacht; verlauf; virus; von; vor; wenn; werden; wird; wochen; während; zeigen; zeigt; zns; zum; zur; über cache: cord-017600-4e7mw041.txt plain text: cord-017600-4e7mw041.txt item: #99 of 549 id: cord-017629-fuv157f1 author: De Groot, Anne S. title: Epitope-Based Immunome-Derived Vaccines: A Strategy for Improved Design and Safety date: 2008-07-31 words: 11196 flesch: 36 summary: The immunome Computational immunology: The coming of age Fitness costs limit viral escape from cytotoxic T lymphocytes at a structurally constrained epitope Design of peptide-based vaccines for cancer Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing The immunodominant influenza matrix T cell epitope recognized in human induces influenza protection in HLA-A2/K(b) transgenic mice A repetitive sequence of Ebstein-Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR restricted CD4+ T lymphocytes Reverse vaccinology and genomics Enhancing DNA immunization Exact prediction of natural T cell epitope T cells primed by influenza virion internal components can cooperate in the antibody response to haemagglutinin Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection CTL epitopes identified with a defective recombinant adenovirus expressing measles virus nucleoprotein and evaluation of their protective capacity in mice Functional analysis of influenza-specific helper T cell clones in vivo. In its minimal form, an IDV would contain only adjuvanated B cell and T cell epitopes in delivery vehicles such as liposomes. keywords: antigens; approach; cell; class; development; epitopes; et al; hiv; hla; human; mhc; mice; peptide; protein; response; sequences; t cell; tools; vaccine cache: cord-017629-fuv157f1.txt plain text: cord-017629-fuv157f1.txt item: #100 of 549 id: cord-017675-in9r33ww author: None title: The Way Forward: Prevention, Treatment and Human Rights date: 2008 words: 18425 flesch: 48 summary: HIV treatment and prevention should be integrated, in HIV prevention strategies fall into four general categories: (1) prevention of sexual transmission; (2) prevention of blood-borne transmission: (3) prevention of mother-to-child transmission; and (4) social strategies. In Ghana cases fell by an eighth and Based on these results, the WHO believes that a 5-year campaign that distributes well for HIV prevention. keywords: access; aids; care; chap; countries; court; discrimination; drug; groups; health; hiv; hiv prevention; hiv transmission; human; international; laws; new; people; prevention; programs; public; rights; risk; sex; states; transmission; treatment; united; use cache: cord-017675-in9r33ww.txt plain text: cord-017675-in9r33ww.txt item: #101 of 549 id: cord-017719-8lfn6mih author: Böhles, Hansjosef title: Infestationen und Infektionen bei Migranten – Die wichtigsten Erkrankungen date: 2018-02-09 words: 4653 flesch: 51 summary: Albendazol ist in Deutschland nur für die Behandlung der Strongylosidiasis und Echinokokkose zugelassen. Es bestehen zwei Impfstrategien: 3-6 Wochen nach der Infektion entsteht in 40-70 % der Fälle eine akute HIV-Infektion. keywords: allem; als; auch; auf; aus; behandlung; bei; bis; das; dem; den; der; des; die; durch; eine; erkrankung; für; hiv; infektion; ist; kann; können; mit; nach; nicht; nur; oder; sich; sie; sind; und; unter; von; vor; werden; wie; wird; wochen; zur; über cache: cord-017719-8lfn6mih.txt plain text: cord-017719-8lfn6mih.txt item: #102 of 549 id: cord-017782-dtveihrj author: Fong, I. W. title: Litigations for HIV Related Complications date: 2010-11-30 words: 6298 flesch: 48 summary: The GP(general practitioner) then initiated a regimen consisting of didanosine, lamivudine, and saquinavir for HIV infection. Specific charges were: (1) the GP should have repeated the HIV serology to confirm that the plaintiff was HIV infected, (2) the defendant was negligent in starting treatment for HIV infection without proof of disease, (3) the physician lacked knowledge of HIV infection and should have referred the patient to a specialist or HIV clinic, (4) treatment of toxic medications were given for several years without any clear indication, and (5) the GP did not adequately inform the patient on the pros and cons of therapy, nor explain the potential toxicities and side-effects. keywords: aids; cd4; cells; count; disease; hiv; infection; patients; progression; test cache: cord-017782-dtveihrj.txt plain text: cord-017782-dtveihrj.txt item: #103 of 549 id: cord-017831-anadq4j9 author: Lai, Yi-Horng title: Network Analysis of Comorbidities: Case Study of HIV/AIDS in Taiwan date: 2015-07-30 words: 3199 flesch: 36 summary: There are no clear boundaries between many diseases, as diseases can have multiple causes and can be related in several dimensions. This study indicates the directionality of disease progression, as observed in our dataset, and finds out that more central disease in the PDN are more likely to occur after other diseases and that more peripheral diseases tend to precede other illnesses. keywords: correlation; diseases; immunodeficiency; immunodeficiency virus; infection; study; virus cache: cord-017831-anadq4j9.txt plain text: cord-017831-anadq4j9.txt item: #104 of 549 id: cord-017885-cz19y60u author: Maziarz, Eileen K. title: Cryptococcosis date: 2014-11-24 words: 10664 flesch: 29 summary: Once a relatively uncommon cause of human disease, cryptococcal infection can develop in apparently immunocompetent hosts and has emerged as an important opportunistic infection in humans over the past several decades as immunocompromised populations expand in the setting of HIV/AIDS, organ transplantation, malignancies, and treatment for other conditions. Early case reports of cryptococcal infections were primarily associated with cancer, autoimmune diseases, organ transplantation, and receipt of corticosteroids as these immunocompromised populations expanded [4] . keywords: aids; antifungal; antigen; clinical; cryptococcal; cryptococcosis; csf; disease; fluconazole; haart; hiv; infection; meningitis; neoformans; patients; syndrome; therapy; treatment cache: cord-017885-cz19y60u.txt plain text: cord-017885-cz19y60u.txt item: #105 of 549 id: cord-017887-pj6pal35 author: OuYang, Bo title: Structural and Functional Properties of Viral Membrane Proteins date: 2018-06-29 words: 11538 flesch: 43 summary: The viral potassium channel Kcv: structural and functional features RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import Unpacking the incoming influenza virus Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses Viroporins: structure and biological functions Chlorovirus-mediated membrane depolarization of Chlorella alters secondary active transport of solutes Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions Viroporins from RNA viruses induce caspase-dependent apoptosis The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding Cytoplasmic domain of influenza B virus BM2 protein plays critical roles in production of infectious virus Solution structure and functional analysis of the influenza B proton channel Identification of specific regions in hepatitis C virus core, NS2 and NS5A that genetically interact with p7 and co-ordinate infectious virus production Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells Mechanism of membrane fusion by viral envelope proteins Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme Structure of influenza haemagglutinin at the pH of membrane fusion HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation Core structure of gp41 from the HIV envelope glycoprotein Mechanism of membrane fusion by viral envelope proteins Intermonomer interactions in hemagglutinin subunits HA1 and HA2 affecting hemagglutinin stability and influenza virus infectivity Class II virus membrane fusion proteins Class II fusion proteins Structure of the dengue virus envelope protein after membrane fusion Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion Characterization of a membraneassociated trimeric low-pH-induced form of the class II viral fusion protein E from tick-borne encephalitis virus and its crystallization Class III viral membrane fusion proteins Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins Class III viral membrane fusion proteins Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol Arbidol as a broad-spectrum antiviral: an update Improved pharmacological and structural properties of HIV fusion inhibitor AP3 over Enfuvirtide: highlighting advantages of artificial peptide strategy Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study B cell responses to HIV-1 infection and vaccination: pathways to preventing infection Structural basis for the function and inhibition of an influenza virus proton channel Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus Crystal structure of the glycophorin We will focus our discussion on two classes of transmembrane (TM) proteins encoded by viruses, viroporins (or viral channels) and membrane fusion proteins, as these proteins have been sought after as antiviral targets and they often exhibit peculiar structural features not seen in other membrane proteins. keywords: am2; binding; c virus; channel; domain; drug; env; fig; fusion; fusion proteins; influenza; influenza virus; membrane; membrane fusion; membrane proteins; nmr; protein; proton; structure; tmd; virus cache: cord-017887-pj6pal35.txt plain text: cord-017887-pj6pal35.txt item: #106 of 549 id: cord-018017-c8myq6bi author: Iversen, Patrick L. title: The Threat from Viruses date: 2018-09-30 words: 11576 flesch: 47 summary: Antisense oligonucleotide-based therapy for HIV-1 infection from laboratory to clinical trials Oligodeoxynucleotide phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus A tribute to Sheik Humarr Khan and all the healthcare workers in West Africa who have sacrificed in the fight against Ebola virus disease: mae we hush Inhibition of Norovirus replication by Morpholino oligomers targeting the 5'-end of the genome Marine viruses: truth or dare Cancer virus Oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infection in two summer campers receiving prophylaxis-North Carolina Approved antiviral drugs of the past 50 years The Eradicatio of smallpox: Edward Jenner and the first and only eradication of a human infectious disease Oseltamivir resistance during treatment of influenza A (H5N1) infection In vitro resistance and in vivo efficacy of antisense oligomer against West Nile virus Outbreak of antiviral drug-resistant influenza A in long-term care facility The perpetual challenge of infectious disease Clonal integration of a polyomavirus in human Merkel cell carcinoma Morpholino oligomers targeting the PB1 and NP genes enhance survival of mice infected with highly pathogenic influenza A H7N7 virus Inhibition of multiple subtypes of influenza a virus in cell cultures with morpholino oligomers Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against Ebola virus and Marburg virus: results of two single ascending dose studies Cytomegalovirus infection and atherosclerosis in candidate of coronary artery bypass graft Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the terminal 3′ stem-loop structure Pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev from human immunodeficiency virus type 1 in the adult male rat following single injections and continuous infusion Phase 2a study of the CCR5 monoclonal antibody PRO 140 administered intravenously to HIV-infected adults Anti-HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibody Oseltamivir for influenza in adults and children: systemic review of clinical study reports and summary of regulatory comments Passive immunity in prevention and treatment of infectious diseases Viral diversity and clonal evolution from unphased genomic data Ecology of viruses in soils: past, present and future perspectives Inhibition of dengue virus serotypes 1 to 4 in cell culture with Morpholino oligomers Inhibition of respiratory Syncitial virus infections in cell cultures and in mice with morpholino oligomers Dissemination, divergence and establishment of H7N9 influenza viruses in China Health impact of globalization: towards global governance Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers Isolation and characterization of a new Vesivirus from rabbits Phosphorothioate analogs of oligodeoxyribonucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus Endogenous retroviruses: with us and against us The value of neuraminidase inhibitors for the prevention and treatment of seasonal influenza: a systematic review of systematic reviews Antisense morpholino oligomers directed against the 5'-end of the genome inhibit coronavirus proliferation and growth Inhibition, escape and attenuation of SARS coronavirus treated with antisense morpholino oligomers Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oliogmers Immunological disorders and malignancies in five young brothers Spillover animal infections and the next human pandemic Deposition rates of viruses and bacteria above the atmospheric boundary layer A prospective monitoring study of cytomegalovirus infection in nonimmunosuppressed critical heart surgery patients Inhibition of acquired immunodeficiency syndrome virus by oligonucleotide methylphosphonates Lymphocytic Choriomeningitis virus infection in FVB mouse produces hemorrhagic disease Ancient Athenian plague proves to be typhoid Inhibition of Measles virus infection in cell cultures by peptide-conjugated Morpholino oligomers Vesivirus viremia and Seroprevalence in humans Virus specific antiviral therapy for controlling severe and fatal outbreaks of feline Calicivirus infection Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge Inhibition of Vesivirus infetions in mammalian tissue culture with antisense morpholino oligomers Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxynucleotide Inhibition of multiple species of picornavirus using a morpholino oligomer targeting highly conserved IRES sequence Increased risk of hepatocellular carcinoma in male hepatiis B surface antigen carriers with chronic hepatitis who have detectable aflatoxin metabolite M1 Viruses in the sea Chemical modifications to phosphorodiamidate Morpholino oligomer antisense molecules targeting VP24 modify their efficacy against Ebola virus infection Use of ChAd3-EBO-Z Ebola virus vaccine in Malian adults with MVA-BN-Filo: a phase I, single-blind, randomized trial, a phase 1b, open label and double blind, doseescallation trial, and a nested, randomized, double-blind, placebo-controlled trial Inhibition of foot-and-mouth disease virus in cell cultures with antisense morpholino oligomers Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture PCR for detection of oseltamivir resistance mutation in influenza A(H7N9) virus IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers Advanced antisense therapies for postexposure protection against lethal filovirus infections Single component AVI-7537 antisense compound provides greater protection than double component AVI-6002 against Lethal Ebola virus infection in Rhesus Monkeys Isolation of an arenavirus closely related to Lassa virus from Mastomys natalensis in south-east Inhibition of coxsackievirus b3 in cell cultures and in mice by Peptide-conjugated morpholino oligomers targeting the internal ribosomal entry site Inhibition of Rous sarcoma virus replication and transformation by a specific oligodeoxynucleotide Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas Effect of early and late GB virus C viremia on survival of HIV-infected individuals: a meta-analysis Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions The focus has been on viral infections because they rely on host ribosomes to produce their proteins, recent emerging infections have been from single-stranded RNA genome viruses, and replication of RNA viruses is error prone. keywords: antisense; antiviral; cell; disease; dna; ebv; et al; genome; hiv; host; human; infected; infections; influenza; inhibition; life; lymphoma; morpholino; oligomers; outbreak; percent; population; rna; studies; table; virus; viruses; years cache: cord-018017-c8myq6bi.txt plain text: cord-018017-c8myq6bi.txt item: #107 of 549 id: cord-018040-k0h5ejjt author: Ilyinskii, P. title: Aspects of Microparticle Utilization for Potentiation of Novel Vaccines: Promises and Risks date: 2009 words: 6938 flesch: 39 summary: In: Levine Virus-like particles: passport to immune recognition Virus-like particles-universal molecular toolboxes Hepatitis B vaccine Improved design and intranasal delivery of an M2e-based human influenza A vaccine Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: followup from a randomised control trial Recent Developments in Vaccine Delivery Systems Immunostimulating Reconstituted Influenza Virosomes Proteosome TM Technology for Vaccines and Adjuvants Protollin: a novel adjuvant for intranasal vaccines MF59 Adjuvant Emulsion The perfect mix: recent progress in adjuvant research Vaccine adjuvants revisited A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM vaccines and conventional vaccines Adjuvant potential of aggregateforming polyglutamine domains Different Interactions between Isomeric Tetrakis-(N-Hexadecylpyridiniumyl) Porphyrins and CdS Nanoparticles Targeting dendritic cells with biomaterials: developing the next generation of vaccines Microparticle-based technologies for vaccines Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: formulation of a model vaccine for respiratory syncytial virus Exploiting lymphatic transport and complement activation in nanoparticle vaccines A practical approach to the use of nanoparticles for vaccine delivery Guard against Gardasil Who's afraid of Gardasil? These biodegradable, biocompatible polymers have been approved for use in humans (e.g., as sutures, bone implants, screws and implants for sustained drug delivery) and have been extensively studied for use in the formulation of vaccine antigens. keywords: adjuvant; antigen; cells; delivery; hiv; influenza; nanoparticles; particles; response; use; vaccination; vaccine; virus cache: cord-018040-k0h5ejjt.txt plain text: cord-018040-k0h5ejjt.txt item: #108 of 549 id: cord-018070-js9vvsud author: Hayes, Anna Marie title: Human Insecurity in the People’s Republic of China: The Vulnerability of Chinese Women to HIV/AIDS date: 2011-10-13 words: 9384 flesch: 46 summary: While China was, traditionally, very much a society whereby passivity was expected of women in sexual matters, after 1949 this situation was widely believed to have altered because of Mao's proclamations about female equality as well as the belief that the 'smashing' of class 7 Surveys conducted in Africa reveal that 60-80% of HIV positive women, who contracted HIV from sexual intercourse, reported that their only sexual partner was their husband. Another study, which was conducted in India, another region where HIV/AIDS is growing at an alarming rate, reveals that 91% of HIV positive women surveyed, who had contracted HIV from sexual intercourse, also reported that their only sexual partner was their husband (Feinstein and Prentice 2000 : 22) . keywords: aids; august; china; chinese; comm; gender; hiv; interviewee; pers; prevention; sex; transmission; vulnerability; women cache: cord-018070-js9vvsud.txt plain text: cord-018070-js9vvsud.txt item: #109 of 549 id: cord-018137-rmtyrbg0 author: Saad, Farouk Tijjani title: Global Stability Analysis of HIV+ Model date: 2018-12-29 words: 2933 flesch: 53 summary: This implies one HIV positive individual in Turkey can be able to transfer the disease to almost 2 individuals, hence there is going to be HIV epidemic in Turkey. Second, HIV prevalence at low prevalence levels become less sensitive to changes in the dynamics of HIV epidemic because it is overpowered by demographic changes especially the recruitment of susceptibles. keywords: aids; epidemic; hiv; model; number; turkey cache: cord-018137-rmtyrbg0.txt plain text: cord-018137-rmtyrbg0.txt item: #110 of 549 id: cord-018440-qugmnolo author: None title: When a Diagnosis Is Reportable date: 2008 words: 2203 flesch: 51 summary: If a patient has not personally notified their partners of their risk for HIV infection, the investigator may then contact all divulged sexual partners for the need to pursue testing and potential treatment for HIV. Identifying patients with HIV infection prior to their developing an HIV-related illness would be beneficial and allow antiretroviral treatment to be initiated earlier. keywords: health; hiv; scott; wife cache: cord-018440-qugmnolo.txt plain text: cord-018440-qugmnolo.txt item: #111 of 549 id: cord-018545-fk17n2bx author: Dorofaeff, Tavey title: Infections in the PICU date: 2012 words: 14182 flesch: 43 summary: Bronchiolitis and other viral respiratory infections in infants with congenital heart disease lead to operative delays and increasing complications post cardiac bypass surgery (e.g., pulmonary hypertension). The following groups are at increased risk of severe infection: • Ex-premature infants and neonates • Infants with congenital heart disease • Infants with immune deficiency • Infants with neuromuscular disease keywords: antibiotics; care; cause; cell; children; days; diagnosis; disease; failure; fever; heart; hiv; illness; infants; infections; management; patients; picu; pneumonia; respiratory; risk; shock; syndrome; therapy; transplant; treatment; unit cache: cord-018545-fk17n2bx.txt plain text: cord-018545-fk17n2bx.txt item: #112 of 549 id: cord-018646-fqy82sm6 author: Huremović, Damir title: Brief History of Pandemics (Pandemics Throughout History) date: 2019-05-16 words: 6865 flesch: 53 summary: Described in detail by Procopius, John of Ephesus, and Evagrius, the Justinian epidemic is the earliest clearly documented example of the actual (bubonic) plague outbreak [16] . Long-term effects of in utero influenza exposure in the Post-1940 U.S. population America's forgotten pandemic: the influenza of 1918 The spread, treatment, and prevention of HIV-1: evolution of a global pandemic Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the global burden of disease study 2015 Academy of consultation-Liaison psychiatry, HIV Psychiatry Bibliography Meta-analysis of the relationship between HIV infection and risk for depressive disorders Cognitive behavioural therapy for adherence and depression in patients with HIV: a three-arm randomised controlled trial The last major outbreak of smallpox (Yugoslavia, 1972): the importance of historical reminders Shining light on dark winter Evaluating public health responses to reintroduced smallpox via dynamic, socially structured, and spatially distributed metapopulation models Extracting key information from historical data to quantify the transmission dynamics of smallpox Responding to global infectious disease outbreaks: lessons from SARS on the role of risk perception, communication and management Summary of probable SARS cases with onset of illness from 1 Was SARS a mental health catastrophe? keywords: death; disease; empire; europe; flu; health; history; hiv; outbreak; pandemic; plague; public; spread; time; virus cache: cord-018646-fqy82sm6.txt plain text: cord-018646-fqy82sm6.txt item: #113 of 549 id: cord-018721-othar2uv author: Schwab, Stefan title: Infektionen date: 2012-03-17 words: 13437 flesch: 30 summary: Die Letalität einer manifesten Erkrankung beträgt beim westlichen Erregersubtyp 1−2 % (bei der myelitischen Neben einem entzündlich veränderten Liquor mit lymphozytärer Pleozytose von einigen 100 Zellen, Eiweißvermehrung und Glucosereduktion fi nden sich bei der Diagnostik chronischer Meningitiden häufi g Allgemeinveränderungen in der EEG-Untersuchung. keywords: abscess; acute; adults; aids; als; auch; auf; aus; bacterial; bakteriellen; bei; bis; brain; bzw; case; cerebral; children; clinical; complications; das; dass; dem; der; des; diagnosis; die; diff; disease; durch; eine; encephalitis; erapie; erkrankung; erreger; fungal; fälle; für; herpes; hiv; human; häufi; infektion; ist; kann; klinische; komplikationen; können; liquor; läsionen; malaria; management; meist; meningitis; mit; mittels; mrt; muss; myelitis; nach; nachweis; nden; neben; nicht; nipah; nur; oder; patienten; patients; pcr; regel; report; review; sein; sich; sie; sind; sollte; sowie; spezifi; study; system; therapie; therapy; treatment; und; verlauf; virus; von; vor; werden; wird; wochen; wurde; zns; zum; zur; über cache: cord-018721-othar2uv.txt plain text: cord-018721-othar2uv.txt item: #114 of 549 id: cord-018785-tcr5xlf8 author: Nambiar, Puja title: Infection in Kidney Transplantation date: 2018-06-27 words: 9374 flesch: 29 summary: A long national experience HIV-positive-to-HIV-positive kidney transplantation-results at 3-5 years Prevention and management of cytomegalovirus infection in solid-organ transplantation Prognosis of HTLV-I-positive renal transplant recipients Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients Infections in solid-organ transplant patients Valganciclovir solid organ transplant study group: efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cyto-megalovirus disease in solid organ transplant recipients Fatal disseminated adenovirus infections in immunocompromised patients Polyoma nephropathy and progressive multifocal leukoencephalopathy in a renal transplant recipient CMV infection is associated with transplant renal artery stenosis Incisional surgical site infection in kidney transplantation BK virus in transplant recipients: an overview and update Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients Impact of early cytomegalovirus infection and disease on longterm recipient and kidney graft survival RESITRA Network of the Spanish Study Group of Infection in Transplantation (2008) Impact of current transplantation management on the development of cytomegalovirus disease after renal transplantation Successful Treatment of Hepatitis C in Renal Transplant Recipients With Direct-Acting Antiviral Agents PHS guideline for reducing human immunodeficiency virus, hepatitis B virus, and hepatitis C virus transmission through organ transplantation Prevalence of HIV-associated nephropathy in autopsies of HIV-infected patients Human herpesvirus-6 in transplantation: an emerging pathogen Rates of first infection following kidney transplant in the United States Up to date Transmission of rabies virus from an organ donor to four transplant recipients Sirolimus for Kaposi's sarcoma in renal transplant recipients Outcomes of kidney transplantation in HIV-infected recipients Preemptive treatment for cytomegalovirus viremia to prevent cytomegalovirus disease in solid organ transplant recipients Viral infections affecting the skin in organ transplant recipients: epidemiology and current management strategies Long-term results in human T-cell leukemia virus type 1-positive renal transplant recipients Post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation Polyomavirus in kidney and kidney-pancreas transplant recipients Epidemiology of kidney disease in the unites states. CMV resistance to ganciclovir has been noted in renal transplant recipients due to mutations in UL 97, the gene responsible for the first phosphorylation step in ganciclovir activation and UL 54, the gene responsible for DNA polymerase (Limaye et al. 2000) . keywords: cmv; disease; donor; et al; infection; kidney; organ; patients; posttransplant; prophylaxis; recipients; renal; risk; therapy; transplant; transplantation; treatment; virus cache: cord-018785-tcr5xlf8.txt plain text: cord-018785-tcr5xlf8.txt item: #115 of 549 id: cord-018864-c1r2n17o author: Pöhlmann, Stefan title: Attachment of human immunodeficiency virus to cells and its inhibition date: 2007 words: 5856 flesch: 33 summary: (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms Primary cultures of endothelial cells from the human liver sinusoid are permissive for human immunodeficiency virus type 1 Detection of HIV1 RNA and p24 antigen in HIV1-infected human liver Presence of HIV-1 in human parenchymal and non-parenchymal liver cells in vivo The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility All but the shortest polymorphic forms of the viral receptor DC-SIGNR assemble into stable homo-and heterotetramers Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens Pattern recognition receptors: doubling up for the innate immune response Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface Characterization of carbohydrate recognition by langerin, a Ctype lectin of Langerhans cells Reproduction of Langerin/CD207 traffic and Birbeck granule formation in a human cell line model Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules Epidermal Langerhans cells -a target for HTLV-III/LAV infection Langerhans' cells are an actual site of HIV-1 replication RNAi-directed inhibition of DC-SIGN by dendritic cells: prospects for HIV-1 therapy The novel cyclophilinbinding drug sanglifehrin A specifically affects antigen uptake receptor expression and endocytic capacity of human dendritic cells Mannose hyperbranched dendritic polymers interact with clustered organization of DC-SIGN and inhibit gp120 binding Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans Prevention of influenza pneumonitis by sialic acid-conjugated dendritic polymers Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN-gp120 interaction Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4 + T lymphocytes Human cervicovaginal lavage fluid contains an inhibitor of HIV binding to dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses Mannose binding lectin (MBL) and HIV Inhibition of DC-SIGN-mediated trans infection of T cells by mannose-binding lectin Mannose-binding lectin binds to Ebola and Marburg envelope glycoproteins, resulting in blocking of virus interaction with DC-SIGN and complement-mediated virus neutralization Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer The highly specific carbohydrate-binding protein cyanovirin-N: structure, anti-HIV/Ebola activity and possibilities for therapy Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques DC-SIGN-specific liposomal targeting and selective intracellular compound delivery to human myeloid dendritic cells: implications for HIV disease High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens We acknowledge numerous contributions from various laboratories whose references were not cited in this review due to space limitations. Cell surface receptors, virus entry and tropism of primate lentiviruses HIV-1 attachment: another look Human immunodeficiency virus type 1 attachment to HeLa CD4 cells is CD4 independent and gp120 dependent and requires cell surface heparans Syndecans serve as attachment receptors for human immunodeficiency virus type 1 on macrophages Syndecan captures, protects, and transmits HIV to T lymphocytes Infection of colonic epithelial cell lines by type 1 human immunodeficiency virus is associated with cell surface expression of galactosylceramide, a potential alternative gp120 receptor Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide Acquisition of host cell-surface-derived molecules by HIV-1 Host protein incorporation is conserved among diverse HIV-1 subtypes Presence of host ICAM-1 in laboratory and clinical strains of human immunodeficiency virus type 1 increases virus infectivity and CD4(+)-T-cell depletion in human lymphoid tissue, a major site of replication in vivo Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions Cellular compartments of human immunodeficiency virus type 1 replication in vivo: determination by presence of virion-associated host proteins and impact of opportunistic infection Detection of HLA-DR associated with monocytotropic, primary, and plasma isolates of human immunodeficiency virus type 1 CD45: A prototype for transmembrane protein tyrosine phosphatases CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation Exclusion of HIV coreceptors CXCR4, CCR5, and CCR3 from the HIV envelope Human immunodeficiency virus type 1 derived from cocultures of immature dendritic cells with autologous T cells carries T-cell-specific molecules on its surface and is highly infectious Cellular proteins bound to immunodeficiency viruses: Implication for pathogenesis and vaccines Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus Envelope glycoproteins are not required for insertion of host ICAM-1 into human immunodeficiency virus type 1 and ICAM-1-bearing viruses are still infectious despite a suboptimal level of trimeric envelope proteins Interaction between the cytoplasmic domain of ICAM-1 and Pr55Gag leads to acquisition of host ICAM-1 by human immunodeficiency virus type 1 The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity Host-derived ICAM-1 glycoproteins incorporated on human immunodeficiency virus type 1 are biologically active and enhances viral infectivity Role of the leukocyte function antigen-1 conformational state in the process of human immunodeficiency virus type 1-mediated syncytium formation and virus infection Regulation of LFA-1 activity through cytoskeleton remodeling and signaling components modulates the efficiency of HIV type-1 entry in activated CD4 + T lymphocytes Presence of host ICAM-1 in human immunodeficiency virus type 1 virions increases productive infection of CD4 + T lymphocytes by favoring cytosolic delivery of viral material LFA-1 is a key determinant for preferential infection of memory CD4 + T cells by human immunodeficiency virus type 1 New insights into the functionality of a virion-anchored host cell membrane protein: CD28 vs HIV type 1 Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle Interaction between virion-bound host ICAM-1 and the high affinity state of LFA-1 on target cells renders R5 and X4 isolates of HIV-1 more refractory to neutralization Virion-bound ICAM-1 and activated LFA-1: a combination of factors conferring resistance to neutralization by sera from human immunodeficiency virus type 1-infected individuals independently of the disease status and phase Susceptibility of HIV type 1 to the fusion inhibitor T-20 is reduced on insertion of host intercellular adhesion molecule 1 in the virus membrane Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus Immunization with class I histocompatibility leukocyte antigen can protect macaques against challenge infection with SIVmac-32H Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion-associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1 Statins inhibit HIV-1 infection by downregulating Rho activity Inhibiting sexual transmission of HIV-1 infection The interaction of immunodeficiency viruses with dendritic cells Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120 DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology DC-SIGN-ICAM-2 interaction mediates dendritic cell trafficking Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells Cell type-dependent retention and transmission of HIV-1 by DC-SIGN Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission Diversity of receptors binding HIV on dendritic cell subsets Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes Infection of dendritic cells (DCs), not DC-SIGN-mediated internalization of human immunodeficiency virus, is required for long-term transfer of virus to T cells DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation Dendritic cells and HIV-specific CD4 + T cells: HIV antigen presentation, T cell activation, viral transfer TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells Expression of DC-SIGN by dendritic cells of intestinal and genital mucosae in humans and rhesus macaques Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells Recruitment of HIV and its receptors to dendritic cell-T cell junctions Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue Lentivirus degradation and DC-SIGN expression by human platelets and megakaryocytes DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes Association of DC-SIGN promoter polymorphism with increased risk for parenteral, but not mucosal, acquisition of human immunodeficiency virus type 1 infection Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1 A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection CD209L keywords: cells; dcs; hiv-1; host; human; immunodeficiency; infection; sign; surface; type; virus cache: cord-018864-c1r2n17o.txt plain text: cord-018864-c1r2n17o.txt item: #116 of 549 id: cord-019347-tj3ye1mx author: None title: ABSTRACT BOOK date: 2010-02-19 words: 108161 flesch: 50 summary: in allergic patients and 250 and 500 ug. In allergic patients after histamine threshold challenge mean decrease was for FEV1 19, 2% and for FEV1/VC 17, 3%. keywords: age; airway; allergen; allergic; allergy; allergy asthma; analysis; anti; antibody; asthma; asthma control; asthma diagnosis; asthma patients; asthma symptoms; atopic; background; baseline; blood; care; case; cd4; cells; chest; children; chronic; conclusion; control; daily; data; day; days; deficiency; desensitization; diagnosis; disease; dose; drug; effect; efficacy; evaluation; exposure; female; following; food; function; group; histamine; history; hours; ics; ige; igg; immune; improvement; increase; infections; inflammatory; introduction; levels; life; low; lung; male; mean; medical; medication; methods; minutes; months; nasal; negative; new; non; normal; number; objective; ova; patients; period; persistent; placebo; pollen; population; positive; prednisone; prevalence; prick; primary; production; pulmonary; quality; rate; reactions; recurrent; report; response; results; rhinitis; rhinitis patients; risk; serum; severity; significant; skin; specific; spray; studies; study; subjects; symptoms; syndrome; testing; tests; therapy; time; total; treatment; urticaria; use; visits; weeks; wheezing; years cache: cord-019347-tj3ye1mx.txt plain text: cord-019347-tj3ye1mx.txt item: #117 of 549 id: cord-019964-9leljj8j author: None title: Recent research in infectious disease date: 2005-01-22 words: 6121 flesch: 44 summary: We examined the risk of developing HSIL among adolescents with and without HIV infection. Methods: HIV-infected (nZ172) and-uninfected (nZ84) girls aged 13-18 years who were participating in a multicenter study of primarily horizontally acquired HIV infections in adolescents (Reaching for Excellence in Adolescent Health Care) and who did not have HSIL on cytologic examination at study entry or at the first follow-up visit were followed at 6-month intervals. Results: At the STI clinic (nZ756 men), we identified 150 men (20%) with Trichomonas vaginalis infection, 358 men (47%) with HIV infection, and 335 men (44%) with Neisseria gonorrhoeae infection. keywords: cases; children; group; gynecomastia; hiv; infected; infection; isolates; men; mrsa; patients; results; risk; study; use; virus; years cache: cord-019964-9leljj8j.txt plain text: cord-019964-9leljj8j.txt item: #118 of 549 id: cord-020010-q58x6xb0 author: None title: 19th ICAR Abstracts: date: 2006-03-13 words: 46881 flesch: 40 summary: Although anti-inflammatory agents are not very active in vitro, it is thought that they might be efficacious in reducing any deleterious inflammatory response associated with virus infections such as SARS infections in humans. Although only BTCRB and BDCRB were inhibitors of the ATPase activity, two other compounds, dBDCRB and Cl4RB, inhibited virus replication in a plaque-reduction assay, thus indicating that those have a different mode of action. keywords: acid; action; activity; agents; animals; antiviral; assay; cdv; cells; combination; compounds; concentrations; containing; control; culture; days; department; derivatives; development; disease; dna; dose; drug; effect; efficacy; gene; hcv; hiv; human; infection; influenza; influenza virus; inhibited; inhibition; inhibitors; institute; mice; model; molecular; mutations; new; novel; nucleoside; polymerase; potent; potential; presence; present; properties; protein; reduction; replication; research; resistance; results; rna; specific; strain; structure; studies; study; synthesis; system; target; tested; therapeutic; therapy; treatment; type; university; usa; virus; virus infection; virus replication; viruses; vitro; vivo cache: cord-020010-q58x6xb0.txt plain text: cord-020010-q58x6xb0.txt item: #119 of 549 id: cord-020101-5rib7pe8 author: None title: Cumulative Author Index for 2008 date: 2008-11-17 words: 2143 flesch: -170 summary: Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus Detection of ovine herpesvirus 2 major capsid gene transcripts as an indicator of virus replication in shedding sheep and clinically affected animals Genetic characterization of equine influenza viruses isolated in Italy between A new living cell-based assay system for monitoring genome-length hepatitis C virus RNA replication Unraveling the puzzle of human anellovirus infections by comparison with avian infections with the chicken anemia virus The contribution of feathers in the spread of chicken anemia virus Cloning and subcellular localization of the phosphoprotein and nucleocapsid proteins of Potato yellow dwarf virus, type species of the genus Nucleorhabdovirus The p26 gene of the Autographa californica nucleopolyhedrovirus: Timing of transcription, and cellular localization and dimerization of product Complete genomic sequence of turkey coronavirus Recombinant L and P protein complex of Rinderpest virus catalyses mRNA synthesis in vitro Molecular divergence of Grapevine virus A (GVA) variants associated with Shiraz disease in South Africa Sequence analysis of a reovirus isolated from the winter moth Operophtera brumata (Lepidoptera: Geometridae) and its parasitoid wasp Phobocampe tempestiva (Hymenoptera: Ichneumonidae SARS coronavirus replicase proteins in pathogenesis Virus-induced gene silencing in Medicago truncatula and Lathyrus odorata Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery HBx modulates iron regulatory protein 1-mediated iron metabolism via reactive oxygen species Pathogenetic mechanisms of severe acute respiratory syndrome Detection of a novel circovirus in mute swans (Cygnus olor) by using nested broadspectrum PCR Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles Cross-species recombination in the haemagglutinin gene of canine distemper virus Sapovirus-like particles derived from polyprotein Cauliflower mosaic virus gene VI product N-terminus contains regions involved in resistance-breakage, self-association and interactions with movement protein Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications Interfering with cellular signaling pathways enhances sensitization to combined sodium butyrate and GCV treatment in EBV-positive tumor cells Evidence for recombination between PCV2a and PCV2b in the field Retroviral reverse transcriptases (other than those of HIV-1 and murine leukemia virus): A comparison of their molecular and biochemical properties Mitochondrial plasmids of sugar beet amplified via rolling circle method detected during curtovirus screening Appearance of intratypic recombination of enterovirus 71 in Taiwan from The circulation of subgenogroups B5 and C5 of enterovirus 71 in Taiwan from In vitro replication of Bamboo mosaic virus satellite Characterization of the interaction of domain III of the envelope protein of dengue virus with putative receptors from CHO cells Intrahost evolution of envelope glycoprotein and OrfA sequences after experimental infection of cats with a molecular clone and a biological isolate of feline immunodeficiency virus The SARS-Coronavirus PLnc domain of nsp3 as a replication/ transcription scaffolding protein Limited compatibility between the RNA polymerase components of influenza virus type A and B Serotype-specificity of recombinant fusion proteins containing domain III of dengue virus Very virulent infectious bursal disease virus isolated from wild birds in Korea: Epidemiological implications Genetic analysis and evaluation of the reassortment of influenza B viruses isolated in Taiwan during the Enhanced immune responses of mice inoculated recombinant adenoviruses expressing GP5 by fusion with GP3 and/or GP4 of PRRS virus Effect of antiviral treatment and host susceptibility on positive selection in hepatitis C virus Novel HIV-1 reverse transcriptase inhibitors Synthesis of recombinant human parainfluenza virus 1 and 3 nucleocapsid proteins in yeast Saccharomyces cerevisiae Evolutionary analyses of European H1N2 swine influenza keywords: analysis; cell; gene; hepatitis c; infection; molecular; murine leukemia; protein; replication; transcriptase; type; virus; virus replication cache: cord-020101-5rib7pe8.txt plain text: cord-020101-5rib7pe8.txt item: #120 of 549 id: cord-020494-d5sreohg author: Schmutzhard, E. title: Entzündliche Erkrankungen date: 2006 words: 9300 flesch: 37 summary: In der Therapie der HIV-Krankheit sind in den letzten Jahren bemerkenswerte Fortschritte erzielt worden, die eine längerfristige Suppression der HIV-Vermehrung und eine Verlangsamung des damit zusammenhängenden progredienten Immundefektes erlauben. In Die antibiotische Therapie der bakteriellen Meningitis wird von den epidemiologischen Gegebenheiten, insbesondere dem Alter des Patienten, der regionalen Resistenzsituation der jeweiligen Erreger und von evtl. keywords: aber; aids; als; antibiotische; auch; auf; bakteriellen; behandlung; bei; bei der; beim; bis; blut; bzw; cjk; das; dem; der; des; diagnose; die; diese; durch; eeg; eine; enzephalitis; enzephalopathie; erkrankung; erreger; evtl; fällen; für; hirnabszess; hiv; infektion; insbesondere; ist; jahren; kann; klinischen; kommt; krankheit; können; liquor; mehr; meist; meningitis; mit; möglich; nach; neben; nicht; nur; oder; patienten; sehr; sich; sind; sollte; sowie; symptomatik; tabelle; therapie; und; unter; verlauf; von; vor; wenn; werden; wird; wochen; z.b; zeichen; zeigen; zeigt; zerebrale; zns; zum; zur; über cache: cord-020494-d5sreohg.txt plain text: cord-020494-d5sreohg.txt item: #121 of 549 id: cord-020778-4jslid14 author: El Sayed, Khalid A. title: Natural Products as Antiviral Agents date: 2007-09-02 words: 12837 flesch: 67 summary: A Novel Polycyclic Guanidine Alkaloid o f Marine Origin New Antiviral an d Cytotoxic Compound s fro m th e Spong e Cramb e crambe Bioactiv e Bisoxazole s from a Marine Sponge Antiviral Indolocarbazole s from a Blue-Green Alg a Belongin g t o th e Nostocaceae Aplidiasphingosine , a n Antimicrobia l Th e Marin e Spong e keywords: acid; activit; activit y; agents; antivira; ar e; b y; cell; compound; dna; drugs; e o; fro; fro m; hiv; hiv-1; host; huma; inhibitor; isolate; marine; n o; natura; new; nove; o f; plant; products; proteins; rna; s o; structure; t o; tha; typ; viral; viru; viruses; vitro; whic; wit; y o cache: cord-020778-4jslid14.txt plain text: cord-020778-4jslid14.txt item: #122 of 549 id: cord-021326-yx0eb885 author: Croser, David title: Infection control since HIV date: 2020-04-06 words: 978 flesch: 52 summary: It is unethical to refuse dental care to patients who disclose a positive diagnosis for a blood-borne virus (BBV) because you feel there could be an increased level of personal risk. This is significant because there is an increasing number of HIV positive patients in the community whose bloodborne disease is controlled with ART-many of whom will also need dental treatment. keywords: care; hiv; patients cache: cord-021326-yx0eb885.txt plain text: cord-021326-yx0eb885.txt item: #123 of 549 id: cord-021382-10omkpwl author: Abdul-Khaliq, Catherine title: Development of a United Kingdom National External Quality Assessment Scheme (UK NEQAS) for HIV point of care testing date: 2011-03-17 words: 4091 flesch: 50 summary: Current users of HIV POCTs in sexual health clinics as well as participants of the UK NEQAS HIV serology scheme that use HIV POCTs were invited to participate in the pilot EQA scheme for HIV point of care testing via letter. Given that the use of HIV POCTs is rising rapidly in the UK and worldwide, the study proposed that EQA of HIV POCT providers is beneficial to ensure quality, reliable results for patients especially in primary care settings where no supporting laboratory is available. keywords: care; eqa; hiv; pocts; results; specimens; testing cache: cord-021382-10omkpwl.txt plain text: cord-021382-10omkpwl.txt item: #124 of 549 id: cord-021481-tvs1pnib author: Singh, Gatikrushna title: Cellular RNA Helicases Support Early and Late Events in Retroviral Replication date: 2018-08-17 words: 6057 flesch: 33 summary: Current understanding of RNA helicase activities in retroviruses has been propelled by results of genome-wide screens. A key to interpreting RNA helicase activity in reverse transcription of retroviral RNA has been the determination of stoichiometry in virions and cognate viral RNA structure, as determined for DHX9 Boeras et al., 2016) . keywords: activity; binding; dhx9; et al; export; helicase; hiv; protein; replication; rev; rna; rnp; transcription; translation; virus cache: cord-021481-tvs1pnib.txt plain text: cord-021481-tvs1pnib.txt item: #125 of 549 id: cord-021668-33zfio0u author: Tyring, Stephen K. title: Syndromal tropical dermatology date: 2009-05-15 words: 6256 flesch: 40 summary: Therefore, the physician should not ignore the common sources of dermatological problems while searching for an exotic etiology. Another, somewhat recent source of patients with tropical skin diseases are adoptees who frequently originate in Central America or Southeast Asia. Tropical Dermatology DOI: 10.1016/b978-0-443-06790-7.50005-3 sha: doc_id: 21668 cord_uid: 33zfio0u nan Stephen K. Tyring With increasing numbers of persons from industrialized, temperate countries traveling and/or working in tropical lands, there is a marked need for physicians to be able to diagnose accurately and treat tropical diseases with mucocutaneous manifestations. keywords: cause; countries; diseases; fever; genital; hiv; infection; lesions; patient; skin; travel; traveler; ulcers cache: cord-021668-33zfio0u.txt plain text: cord-021668-33zfio0u.txt item: #126 of 549 id: cord-021872-rhi7hi9m author: Wilkes, Rebecca P. title: Update on Antiviral Therapies date: 2015-12-04 words: 9945 flesch: 43 summary: -2,6-diaminopurine (PMPDAP) in the treatment of feline immunodeficiency virusinfected cats their discovery, development, and use in the treatment of HIV-1 infection: A review of the last 20 years Susceptibility of feline immunodeficiency virus/ human immunodeficiency virus type 1 reverse transcriptase chimeras to non-nucleoside RT inhibitors Clinical aspects of feline immunodeficiency and feline leukemia virus infection Is AZT/3TC therapy effective against FIV infection or immunopathogenesis? Lymphocyte-cell immunomodulator (LTCI): review of the immunopharmacology of a new veterinary biologic Discovery of drugs that possess activity against feline leukemia virus A trial with 3′-azido-2′,3′-dideoxythymidine and human interferon-a in cats naturally infected with feline leukaemia virus Inhibition of feline leukemia virus replication by the integrase inhibitor Raltegravir Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture A 40-year journey in search of selective antiviral chemotherapy Effects of valacyclovir in cats infected with feline herpesvirus 1 Evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1 In vitro cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolites Treatment of feline herpesvirus-1 associated disease in cats with famciclovir and related drugs Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study Feline herpesvirus-1: ocular manifestations, diagnosis and treatment options Effect of topical ophthalmic application of cidofovir on experimentally induced primary ocular feline herpesvirus-1 infection in cats Evaluation of the effects of small interfering RNAs on in vitro replication of feline herpesvirus-1 Use of interfering RNAs targeted against feline herpesvirus 1 glycoprotein D for inhibition of feline herpesvirus 1 infection of feline kidney cells Therapeutic siRNA: principles, challenges, and strategies Evaluation of delivery agents used for introduction of small interfering RNAs into feline corneal cells Excess dietary lysine does not cause lysinearginine antagonism in adult cats Effects of physiologic concentrations of L-lysine on in vitro replication of feline herpesvirus 1 Oral supplementation with L-lysine did not prevent upper respiratory infection in a shelter population of cats Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C-like protease Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus Effect of Polyprenyl Immunostimulant on the survival times of three cats with the dry form of feline infectious peritonitis An update on feline infectious peritonitis: virology and immunopathogenesis Randomized, placebo controlled study of the effect of propentofylline on survival time and quality of life of cats with feline infectious peritonitis Interferons: signaling, antiviral and viral evasion Use of recombinant interferon omega in feline retrovirosis: from theory to practice Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter Oral recombinant feline interferon-omega as an alternative immune modulation therapy in FIV positive cats: clinical and laboratory evaluation Comparative efficacy of a recombinant feline interferon omega in refractory cases of calicivirus-positive cats with caudal stomatitis: a randomised, multi-centre, controlled, doubleblind study in 39 cats Lowdose interferon-treatment for feline immunodeficiency virus infection Therapeutic effects of recombinant feline interferon-omega on feline leukemia virus (FeLV)-infected and FeLV/feline immunodeficiency virus (FIV)-coinfected symptomatic cats Effects of topical ocular administration of high doses of human recombinant interferon alpha-2b and feline recombinant interferon omega on naturally occurring viral keratoconjunctivitis in cats Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis Feline leukemia virus causes a wide variety of clinical signs in infected cats (Figure 7 -3). keywords: antiviral; cats; cell; drug; feline; felv; fhv-1; fiv; hiv; infection; studies; study; therapy; treatment; virus cache: cord-021872-rhi7hi9m.txt plain text: cord-021872-rhi7hi9m.txt item: #127 of 549 id: cord-021966-5m21bsrw author: Shaw, Alan R. title: Vaccines date: 2009-05-15 words: 21179 flesch: 27 summary: 67 n NeW ANTIGeN dISCOVeRy MeThOdS n Historically, vaccine antigens were not discovered in the literal sense. The history of vaccine development is rich with immunologic insights that emerged from careful observations of how diseases spread in populations and how such spread differs in disease-naïve and experienced populations, as well as of how innovative experimental approaches revealed fundamental aspects of immune system function. keywords: adjuvant; antibody; antigens; cell; development; disease; dna; efforts; gene; hiv; host; human; immunity; immunization; individuals; infection; live; number; pathogen; protection; protein; responses; rotavirus; safety; studies; use; vaccination; vaccine; vaccine development; vectors; virus cache: cord-021966-5m21bsrw.txt plain text: cord-021966-5m21bsrw.txt item: #128 of 549 id: cord-021990-a8ku5rke author: Tyring, Stephen K. title: Syndromal Tropical Dermatology date: 2016-12-02 words: 7078 flesch: 42 summary: Part I. Insecta Tropical dermatology: marine and aquatic dermatology Tropical dermatology: tropical diseases caused by protozoa Tropical dermatology: bacterial tropical diseases Tropical dermatology: fungal tropical diseases Since the first publication of Tropical Dermatology in 2006, many tropical diseases previously unknown in temperate countries have been reported to have been transmitted outside the tropics (e.g., Ebola, Chikungunya, and Zika viruses), or have markedly increased their endemic areas (e.g., Chagas disease). keywords: cause; countries; disease; fever; genital; hiv; infection; lesions; non; skin; travel; traveler; tropical; virus; viruses cache: cord-021990-a8ku5rke.txt plain text: cord-021990-a8ku5rke.txt item: #129 of 549 id: cord-022128-r8el8nqm author: Domingo, Esteban title: Molecular basis of genetic variation of viruses: error-prone replication date: 2019-11-08 words: 17674 flesch: 30 summary: Mechanisms and Consequences Structure-function relationships underlying the replication fidelity of viral RNAdependent RNA polymerases Phage as agents of lateral gene transfer Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective Mutations and A/I hypermutations in measles virus persistent infections Evolution of sex in RNA viruses Viral RNAdirected RNA polymerases use diverse mechanisms to promote recombination between RNA molecules Insertion/deletion frequencies match those of point mutations in the hypervariable regions of the simian immunodeficiency virus surface envelope gene Arbovirus high fidelity variant loses fitness in mosquitoes and mice Genetic variation in retroviruses Variation in RNA virus mutation rates across host cells Parallel evolution of drug resistance in HIV: failure of nonsynonymous/synonymous substitution rate ratio to detect selection The vaccinia virus DNA polymerase and its processivity factor Silent mutations in sight: co-variations in tRNA abundance as a key to unravel consequences of silent mutations Improvement of phi29 DNA polymerase amplification performance by fusion of DNA binding motifs Linking RNA sequence, structure, and function on massively parallel highthroughput sequences Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals? Virus entry into error catastrophe as a new antiviral strategy Viral Quasispecies Nucleotide sequence heterogeneity of an RNA phage population Genetic variability and antigenic diversity of foot-and-mouth disease virus Quasispecies: the concept and the word Quasispecies and RNA Virus Evolution: Principles and Consequences Evolution of footand-mouth disease virus Viral quasispecies: dynamics, interactions and pathogenesis A constant rate of spontaneous mutation in DNA-based microbes Mutation rates among RNA viruses Detenction of truncated virus particles in a persistent RNA virus infection in vivo Evolvability is a selectable trait High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing Error catastrophe and antiviral strategy Sequence space and quasispecies distribution Adaptive value of high mutation rates of RNA viruses: separating causes from consequences Multiple molecular pathways for fitness recovery of an RNA virus debilitated by operation of Muller's ratchet RT-PCR amplification and cloning of large viral sequences Adaptation of mRNA structure to control protein folding A comparison of viral RNA-dependent RNA polymerases Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase Random mutagenesis using error-prone DNA polymerases Specialized DNA polymerases, cellular survival, and the genesis of mutations DNA Repair and Mutagenesis Statistical tests of neutrality of mutations against population growth, hitchhiking and background selection Extremely high mutation rate of a hammerhead viroid RNA recombination in vivo in the absence of viral replication Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus DNA replication-a matter of fidelity Evolutionary transition toward defective RNAs that are infectious by complementation Information dynamics in carcinogenesis and tumor growth Evolution of circulating wild poliovirus and of vaccine-derived poliovirus in an immunodeficient patient: a unifying model In-depth, longitudinal analysis of viral quasispecies from an individual triply infected with late-stage human immunodeficiency virus type 1, using a multiple PCR primer approach Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution Molecular Basis of Virus Evolution Functional and genetic plasticities of the poliovirus genome: quasi-infectious RNAs modified in the 5'-untranslated region yield a variety of pseudorevertants Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? Mutation frequencies measured by subjecting virus to a specific selective agent (e.g., mutants that escape the neutralizing activity of a monoclonal antibody or mutants that escape inhibition by a drug) span a broad range of values (10 À 3 to 10 À 8 ) for DNA and RNA viruses (Smith and Inglis, 1987; Sarisky et al., 2000; Domingo et al., 2001) (Table 2 .1). keywords: acid; amino; cells; chapter; dna; error; et al; evolution; fidelity; forms; frequency; genome; mechanisms; mutant; mutation; mutation rates; nucleotide; polymerase; rates; reassortment; recombination; repair; replication; rna; rna viruses; selection; sequence; site; template; type; variation; viral; virus; viruses cache: cord-022128-r8el8nqm.txt plain text: cord-022128-r8el8nqm.txt item: #130 of 549 id: cord-022141-yxttl3gh author: Siegel, Frederic R. title: Progressive Adaptation: The Key to Sustaining a Growing Global Population date: 2014-08-23 words: 11118 flesch: 51 summary: Initially, and for many years thereafter, the added greenhouse gases were taken up by vegetation for photosynthesis and was also absorbed by the oceans and other water bodies. For smaller waterways that flow through cities, municipalities may invest in deepening, widening, and straightening channels as well as erecting walls so that more water can flow through the area more rapidly without coming out of a channel. keywords: adaptation; cases; change; climate; conditions; countries; disease; fever; food; future; health; level; nations; people; population; transmission; use; vaccine; warming; water; world cache: cord-022141-yxttl3gh.txt plain text: cord-022141-yxttl3gh.txt item: #131 of 549 id: cord-022168-qautse9a author: Liu, Li title: Clinical Use of DNA Vaccines date: 2017-07-25 words: 7126 flesch: 34 summary: Additional insight gained from the success of DNA vaccines in veterinary practice is that the DNA scaling-up might not be a potential hindrance for DNA vaccine being effective in humans. intradermal (i.d.) administration (VRC 011) HIV DNA Vaccine: stepwise improvements make a difference DNA vaccines: developing new strategies against cancer The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials Targeting plasmid-encoded proteins to the antigen presentation pathways Therapeutic HPV DNA vaccines DNA vaccines: an historical perspective and view to the future Prospects for control of emerging infectious diseases with plasmid DNA vaccines HIV therapeutic vaccines: moving towards a functional cure Clinical development of a cytomegalovirus DNA vaccine: from product concept to pivotal phase 3 trial Xenogeneic human p53 DNA vaccination by electroporation breaks immune tolerance to control murine tumors expressing mouse p53 Genetic immunization is a simple method for eliciting an immune response Using plasmids as DNA vaccines for infectious diseases Induction of broadly neutralizing H1N1 influenza antibodies by vaccination Direct gene transfer into mouse muscle in vivo DNA vaccine for cancer immunotherapy ▶ Gene Delivery by Electroporation In Vitro: Mechanisms keywords: antigen; cancer; cells; delivery; dna; immunogenicity; influenza; plasmid; proteins; responses; tumor; vaccine cache: cord-022168-qautse9a.txt plain text: cord-022168-qautse9a.txt item: #132 of 549 id: cord-022348-w7z97wir author: Sola, Monica title: Drift and Conservatism in RNA Virus Evolution: Are They Adapting or Merely Changing? date: 2007-09-02 words: 10898 flesch: 50 summary: Muller's ratchet decreases fitness of a DNA-based microbe Increased immune response elicited by DNA vaccination with a synthetic gp120 sequence with optimized codon usage The phylogeny of The Canterbury Tales Isolation of new ribozymes from a large pool of random sequences Forced evolution of a regulatory RNA helix in the HIV-1 genome Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity Molecular Mechanisms of Immune Responses in Insects Nucleotide composition as a driving force in the evolution of retroviruses Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: implications for virus evolution Role of host immune response in selection of equine infectous anemia virus variants Fitness of RNA virus decreased by Muller's ratchet Evolution of sex and the molecular clock in RNA viruses HIV and T-cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T-lymphocytes Antigenic stimulation by BCG as an in vivo driving force for SIV replication and dissemination Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses Nucleotide sequences of three Nodavirus RNA2's: the messengers for their coat protein precursors Primary and secondary structure of black beetle virus RNA2, the genomic messenger for BBV coat protein precursor HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly Al1+ population T cell responses and virus evolution: loss of HLA All-restricted CTL epitopes in Epstein-Barr virus isolates from highly All-positive populations by selective mutation of anchor residues RNA virus quasispecies populations can suppress vastly superior mutant progeny The genome sequence of herpes simplex virus type 2 RNA viral mutations and fitness for survival Basic concepts in RNA virus evolution Origins and evolutionary relationships of retroviruses Rates of spontaneous mutations among RNA viruses Rapid fitness losses in mammalian RNA virus clones due to Muller's ratchet High viral load and CD4 lymphopenia in rhesus and cynomolgus macaques infected by a chimeric primate lentivirus constructed using the env, rev, tat, and vpu genes from HIV-1 Lai The viral quasispecies Sequence space and quasispecies distribution Structurally complex and highly active RNA ligases derived from random RNA sequences Does the VP1 gene of foot-and-mouth disease virus behave as a molecular clock? key: cord-022348-w7z97wir authors: Sola, Monica; Wain-Hobson, Simon title: Drift and Conservatism in RNA Virus Evolution: Are They Adapting or Merely Changing? date: 2007-09-02 journal: Origin and Evolution of Viruses DOI: 10.1016/b978-012220360-2/50007-6 sha: doc_id: 22348 cord_uid: w7z97wir This chapter argues that the vast majority of genetic changes or mutations fixed by RNA viruses are essentially neutral or nearly neutral in character. keywords: acid; amino; et al; evolution; example; figure; fitness; genomes; hiv; human; immunodeficiency; mutations; number; proteins; rna; selection; sequence; substitutions; variation; virus; viruses; vivo cache: cord-022348-w7z97wir.txt plain text: cord-022348-w7z97wir.txt item: #133 of 549 id: cord-022380-49oti4zg author: Panlilio, Adelisa L title: Occupational Infectious Diseases date: 2009-05-15 words: 15593 flesch: 39 summary: To the extent that unsafe practices have been defined, and practice policies modified to reduce infection risk, continued transmission often represents failure to follow accepted standards. Recognition of the types of infection risk associated with specific occupations can, in most cases, lead to effective, often simple steps for primary prevention, as well as opportunities for early diagnosis and treatment. keywords: adults; blood; children; contact; control; days; disease; exposure; hcv; healthcare; hepatitis; hiv; immunization; infection; influenza; patients; personnel; persons; risk; transmission; treatment; vaccine; virus; workers cache: cord-022380-49oti4zg.txt plain text: cord-022380-49oti4zg.txt item: #134 of 549 id: cord-022521-r72jtoso author: Miller, Tracie L. title: Gastrointestinal Complications of Secondary Immunodeficiency Syndromes date: 2010-12-27 words: 13743 flesch: 30 summary: Ganciclovir: an update of its use in the prevention of cytomegalovirus infection and disease in transplant recipients Safety and efficacy of prolonged cytomegalovirus prophylaxis with intravenous ganciclovir in pediatric and young adult lung transplant recipients Hepatitis B in the HIV-coinfected patient Hepatitis B or hepatitis C and human immunodeficiency virus infection Influence of HIV infection on the response to interferon therapy and the long-term outcome of chronic hepatitis B Effect of duration of hepatitis B virus infection on the association between human immunodeficiency virus type-1 and hepatitis B viral replication Hepatitis B virus infection in the acquired immunodeficiency syndrome Adolescent human immunodeficiency virus infection and gastrointestinal disease Effect of HIV co-infection on mutation patterns of HBV in patients with lamivudine-resistant chronic hepatitis Hepatitis B in HIV patients: What is the current treatment and what are the challenges? Diagnosis and management of hepatitis B virus and HIV coinfection Hepatitis C in patients with human immunodeficiency virus infection: diagnosis, natural history, meta-analysis of sexual and vertical transmission, and therapeutic issues Maternal-infant transmission of hepatitis C virus and HIV infections: A possible interaction Coinfection with HIV-1 and HCV -a one-two punch HIV and hepatitis C coinfection Protection against persistence of hepatitis C Later, in 1984, 4 HIV-1 was determined to be the causative agent, and HIV-1 infection was recognized as a spectrum of disease, ranging from asymptomatic infection to full-blown AIDS. keywords: aids; associated; bacterial; cd4; cells; children; chronic; diarrhea; disease; function; gastrointestinal; haart; hepatitis; hiv-1; human; immunodeficiency; infection; malabsorption; patients; studies; therapy; tract; treatment; virus cache: cord-022521-r72jtoso.txt plain text: cord-022521-r72jtoso.txt item: #135 of 549 id: cord-022535-08hqmwlg author: Schmiedel, Stefan title: Infektionen, Impfungen, Reisemedizin date: 2013-06-26 words: 6083 flesch: 44 summary: der Pat. AIDS, 20 % symptomfrei. Nach 15 J. bei 65 % der Pat. AIDS, 8 % symptomfrei. keywords: aids; als; auch; auf; bei; bis; bzw; cave; das; dem; der; des; die; durch; eine; evtl; fieber; für; haut; hiv; immunglobulin; impfstoff; impfung; impfungen; inf; ist; kinder; klinik; mit; muss; möglich; nach; nicht; nur; oder; pat; prophylaxe; sind; ther; und; von; vor; wenn; werden; wird; z.b; zum; zur; über cache: cord-022535-08hqmwlg.txt plain text: cord-022535-08hqmwlg.txt item: #136 of 549 id: cord-022633-fr55uod6 author: None title: SAEM Abstracts, Plenary Session date: 2012-04-26 words: 147610 flesch: 49 summary: Objectives: To identify the prevalence of NCS and other EEG abnormalities in ED patients with AMS. Objectives: Test the hypothesis that prior to antibiotic administration, circulating LPS can be detected in the plasma of fewer than 10% of ED patients with severe sepsis. keywords: academic; acute; admission; adult ed; adult patients; age; analysis; arrest; arrest patients; assessment; association; average; background; blood; cardiac; care; cases; center; change; characteristics; chest; children; clinical; cohort; conclusion; confidence; control; cpr; criteria; data; days; department; diagnosis; difference; discharge; disease; ed care; ed patients; ed physicians; ed visits; eds; effect; emergency; emergency department; ems; evaluation; factors; following; group; health; high; hospital; hospital ed; hours; implementation; increase; information; initial; injury; inpatient; intervention; intubation; length; level; los; low; management; mean; median; medical; medicine; methods; minutes; model; months; mortality; n =; non; number; objectives; outcomes; overall; p =; pain; pain patients; participants; pediatric; performance; period; population; post; pre; prehospital; primary; prior; program; protocol; providers; quality; range; rate; regression; research; residency; residents; respectively; results; retrospective; review; risk; sample; score; screening; self; sepsis; setting; shock; standard; students; studies; study; study ed; subjects; survey; survival; system; table; test; testing; time; total; training; trauma patients; treatment; triage; urban; use; years cache: cord-022633-fr55uod6.txt plain text: cord-022633-fr55uod6.txt item: #137 of 549 id: cord-022888-dnsdg04n author: None title: Poster Sessions date: 2009-08-19 words: 189173 flesch: 41 summary: Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines. keywords: + cells; ability; absence; activity; addition; analysis; antibodies; antibody; antigen; apoptosis; apoptotic; assay; associated; autoimmune; b cells; b t; binding; blood; bone; c mice; cancer cells; capacity; cd4; cd8 +; cd8 cells; cd8 t; cell activation; cell activity; cell culture; cell cycle; cell death; cell development; cell differentiation; cell epitopes; cell function; cell level; cell lines; cell membrane; cell population; cell proliferation; cell receptor; cell responses; cell subsets; cell surface; cell tolerance; cell types; cells cells; changes; chronic; class; clinical; colitis; complex; conclusion; contrast; control; control cells; cross; ctl; cytokine; cytokine production; cytometry; cytotoxic t; data; day; days; dcs; deficient; delta t; dendritic; disease; dna; early; effector cells; effector t; effects; elisa; expansion; experiments; expression; expression levels; factor; family; findings; flow; following; formation; function; gamma; gd cells; gd t; gene; gene expression; group; high; hiv; hla; host; human; ifn; ifng; igg; il-10; il-2; il-4; il-6; immune; immunity; increase; independent; induction; infected; infection; inflammation; inflammatory; inhibition; inkt; interaction; intracellular; levels; lps; macrophages; major; marrow cells; mast cells; mechanisms; membrane; memory t; methods; mhc; mice; model; molecules; monocytes; mouse; mouse t; mrna; murine; negative; neutrophils; new; nkt cells; non; normal; novel; number; objectives; pathway; patients; pcr; peptide; peripheral; plasma cells; play; positive; potential; presence; presentation; primary; production; promoter; protein; protein expression; receptors; regulation; regulatory; release; results; role; secretion; serum; signaling; skin; sle; specific; spleen; stem cells; stimulation; studies; study; surface expression; system; t cells; t em; t h; t helper; t lymphocytes; target cells; tcr; test; th1 cells; time; tissue; tlr; tnf; tolerance; transcription; treatment; tumor cells; type; university; vaccination; vaccine; vg9vd2 t; virus; vitro; vivo; work cache: cord-022888-dnsdg04n.txt plain text: cord-022888-dnsdg04n.txt item: #138 of 549 id: cord-023017-k6edtg58 author: None title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 words: 65964 flesch: 47 summary: The aim of the present study was to investigate if the same inhibition takes place in livers cells of patients with chronic hepatitis C. From February 2001 to April 2002, all patients with chronic hepatitis C referred to the outpatient liver clinic of the University Hospital Basel were asked for their permission to use part of the liver biopsy for this study. Increased T cell activation with Eta may also suggest that TNFA suppress T cell function and may contribute to refractoriness to INF therapy in HCV patients. keywords: -no; activation; activity; addition; age; alpha; alt; analysis; anti; biopsies; biopsy; blood; cases; cd8; cells; chronic; chronic hcv; chronic hepatitis; cirrhosis; combination; conclusions; control; core; culture; data; days; dcs; different; disease; dose; effect; expression; factors; fibrosis; gene; genotype; group; hcc; hcv; hcv genotype; hcv infection; hcv patients; hcv rna; hepatic; hepatitis; hepatocytes; hsc; human; ifn; infection; interferon; levels; liver; mean; meld; methods; mice; months; negative; non; ns3; patients; pcr; population; positive; protein; rats; rejection; relationships; response; results; ribavirin; risk; role; serum; specific; steatosis; stem; studies; study; subjects; survival; system; t cells; therapy; time; total; transplantation; treated; treatment; virus; weeks; years cache: cord-023017-k6edtg58.txt plain text: cord-023017-k6edtg58.txt item: #139 of 549 id: cord-023143-fcno330z author: None title: Molecular aspects of viral immunity date: 2004-02-19 words: 43520 flesch: 44 summary: The immunohistological analysis suggests that CD8+ T cell dependent disappearence of marginal zone macrophages of follicular dendritic cells and of virus infected cells in general correlates with immunosuppression. Our studies indicate that MHC class I resmcted CD8+ cytotoxic T lymphocytes (CTLs) are activated in response to viral antigens leading to destruction of virus infected cells and loss of transgene expression. keywords: activity; amino; analysis; animals; antibodies; antibody; antigen; b cells; binding; cd4; cd8; cell responses; challenge; class; clones; cns; ctl; ctl response; cytokines; cytotoxic t; days; different; disease; dna; epitopes; expression; gene; hiv; hla; host; human; ifn; immune; immunity; infected; infection; influenza; lcmv; levels; lymphocytes; memory; mhc; mice; model; molecules; mouse; murine; peptides; primary; production; protein; recognition; recombinant; replication; response; results; role; sequence; specific; spleen; strains; studies; t cells; type; vaccine; vaccinia; viral; virus; virus infection; viruses; vivo cache: cord-023143-fcno330z.txt plain text: cord-023143-fcno330z.txt item: #140 of 549 id: cord-023168-cd7adns8 author: Thachil, Jecko title: Haematological Diseases in the Tropics date: 2013-10-21 words: 30246 flesch: 37 summary: WHD/3 Information sheet for clinicians Development and evaluation of a new paediatric blood transfusion protocol for Africa Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans Use of clinical judgement to guide administration of blood transfusions in Malawi Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation Autologous transfusion techniques: a systematic review of their efficacy Intraoperative autologous blood management Artificial O2 carriers: status in 2005 Red blood cell transfusions in acute paediatrics Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi Intermittent preventive therapy for malaria with monthly artemether-lumefantrine for the post-discharge management of severe anaemia in children aged 4-59 months in southern Malawi: a multicentre, randomised, placebocontrolled trial Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital Bacterial contamination of blood and blood components in three major blood transfusion centres in Accra, Ghana Access the complete references online at www.expertconsult.com Causes and outcomes of the acute chest syndrome in sickle cell disease The acute chest syndrome in sickle cell disease: incidence and risk factors Acute chest syndrome in sickle-cell disease Bronchoalveolar lavage in adult sickle cell patients with acute chest syndrome: value for diagnostic assessment of fat embolism Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome Cerebrovascular accidents in sickle cell disease: rates and risk factors Pathophysiology and treatment of stroke in sicklecell disease: Present and future Lesion burden and cognitive morbidity in children with sickle cell disease Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: A report from the Cooperative Study of Sickle Cell Disease Nocturnal hypoxaemia and central-nervoussystem events in sickle-cell disease Natural history of blood pressure in sickle cell disease: Risks for stroke and death associated with relative hypertension in sickle cell anemia Prophylaxis with oral penicillin in children with sickle cell anemia. keywords: acute; anaemia; bleeding; blood; blood transfusion; bone; cause; cell; cell disease; children; chronic; complications; countries; deficiency; diagnosis; disease; factor; folate; g6pd; haemoglobin; haemolysis; hiv; individuals; infections; iron; iron deficiency; levels; lymphoma; major; malaria; management; marrow; patients; platelet; prevalence; risk; scd; syndrome; thalassaemia; therapy; thrombocytopenia; transfusion; treatment; vitamin; years cache: cord-023168-cd7adns8.txt plain text: cord-023168-cd7adns8.txt item: #141 of 549 id: cord-023346-8sqbqjm1 author: None title: MONDAY: POSTERS date: 2005-06-08 words: 130150 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: aim; analysis; anti; antibodies; antibody; antigens; apheresis; assay; associated; background; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood donation; blood donors; blood establishments; blood group; blood loss; blood plasma; blood pressure; blood products; blood safety; blood samples; blood service; blood supply; blood system; blood transfusion; blood units; blood volume; cases; clinical; complications; concentrates; conclusion; control; cord blood; count; data; day; days; detection; disease; dna; donations; effect; events; factor; ffp; following; frequency; general; groups; hbsag; hbv; hcv; health; high; hla; hospital; hospital blood; identification; important; increase; infections; information; introduction; iron; laboratory; level; low; major; management; mean; medical; methods; national; negative; new; non; number; order; patients; pcr; period; plasma; platelet; platelet transfusion; population; positive; post; practice; presence; present; procedure; process; quality; range; rbc; rbc transfusion; rbcs; red; results; rhd; risk; routine; screening; serum; specific; standard; storage; studies; study; surgery; system; table; test; tested; testing; therapy; time blood; total; transfusion medicine; transfusion reactions; transfusion service; transfusion therapy; transfusions; treatment; type; use; weak; women; years cache: cord-023346-8sqbqjm1.txt plain text: cord-023346-8sqbqjm1.txt item: #142 of 549 id: cord-023354-f2ciho6o author: None title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 words: 130154 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: aim; analysis; anti; antibodies; antibody; antigens; apheresis; assay; associated; background; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood donation; blood donors; blood establishments; blood group; blood loss; blood plasma; blood pressure; blood products; blood safety; blood samples; blood service; blood supply; blood system; blood transfusion; blood units; blood volume; cases; clinical; complications; concentrates; conclusion; control; cord blood; count; data; day; days; detection; disease; dna; donations; effect; events; factor; ffp; following; frequency; general; groups; hbsag; hbv; hcv; health; high; hla; hospital; hospital blood; identification; important; increase; infections; information; introduction; iron; laboratory; level; low; major; management; mean; medical; methods; national; negative; new; non; number; order; patients; pcr; period; plasma; platelet; platelet transfusion; population; positive; post; practice; presence; present; procedure; process; quality; range; rbc; rbc transfusion; rbcs; red; results; rhd; risk; routine; screening; serum; specific; standard; storage; studies; study; surgery; system; table; test; tested; testing; therapy; time blood; total; transfusion medicine; transfusion reactions; transfusion service; transfusion therapy; transfusions; treatment; type; use; weak; women; years cache: cord-023354-f2ciho6o.txt plain text: cord-023354-f2ciho6o.txt item: #143 of 549 id: cord-023364-ut56gczm author: None title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 words: 130157 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: aim; analysis; anti; antibodies; antibody; antigens; apheresis; assay; associated; background; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood donation; blood donors; blood establishments; blood group; blood loss; blood plasma; blood pressure; blood products; blood safety; blood samples; blood service; blood supply; blood system; blood transfusion; blood units; blood volume; cases; clinical; complications; concentrates; conclusion; control; cord blood; count; data; day; days; detection; disease; dna; donations; effect; events; factor; ffp; following; frequency; general; groups; hbsag; hbv; hcv; health; high; hla; hospital; hospital blood; identification; important; increase; infections; information; introduction; iron; laboratory; level; low; major; management; mean; medical; methods; national; negative; new; non; number; order; patients; pcr; period; plasma; platelet; platelet transfusion; population; positive; post; practice; presence; present; procedure; process; quality; range; rbc; rbc transfusion; rbcs; red; results; rhd; risk; routine; screening; serum; specific; standard; storage; studies; study; surgery; system; table; test; tested; testing; therapy; time blood; total; transfusion medicine; transfusion reactions; transfusion service; transfusion therapy; transfusions; treatment; type; use; weak; women; years cache: cord-023364-ut56gczm.txt plain text: cord-023364-ut56gczm.txt item: #144 of 549 id: cord-023669-3ataw6gy author: Masur, Henry title: Critically Ill Immunosuppressed Host date: 2009-05-15 words: 11198 flesch: 30 summary: HIV patients pose a risk to health care professionals, however. For such patients, mucormycosis and non-albicans Candida are becoming more prominent causes of morbidity. keywords: cd4; ciency; cmv; diagnosis; disease; drugs; empiric; hiv; immunodefi; infection; lymphocyte; neutropenia; organ; patients; pneumonia; risk; specifi; therapy cache: cord-023669-3ataw6gy.txt plain text: cord-023669-3ataw6gy.txt item: #145 of 549 id: cord-023729-dipjubn7 author: Serlin, Michael H. title: Gastrointestinal Disorders in HIV date: 2009-05-15 words: 5864 flesch: 40 summary: Pneumocystis jiroveci (PCP) can also be seen as the cause of diarrhea in HIV patients, but is very uncommon, especially in the setting of PCP prophylaxis for AIDS patients; treatment is with antipneumocystis therapy, 38 generally with trimethoprim-sulfamethoxazole. Patients can have both dysphagia and odynophagia, and because they also may have more than one illness concurrently, it is imperative to pursue a thorough investigation as to the etiology of esophageal complaints in HIV patients. keywords: addition; diarrhea; disease; esophageal; esophagitis; hiv; hiv patients; patients; therapy; treatment cache: cord-023729-dipjubn7.txt plain text: cord-023729-dipjubn7.txt item: #146 of 549 id: cord-023841-amfb4jft author: Scherr, Johannes title: Bewegung und Erkrankungen des Immunsystems date: 2017 words: 4667 flesch: 32 summary: Die humanen Immundefizienzviren (HIV) HIV-1 und HIV-2 sind Vertreter humanpathogener Lentiviren in der Familie der Retroviridae und Auslöser der erworbenen Immunschwäche AIDS (Acquired Immunodeficiency Syndrome). Aufgrund der unterschiedlichen Definitionen liegt hier aber eine deutliche Schwankungsbreite vor, so dass in Anhängigkeit der benutzen Kriterien als auch der untersuchten Population auch eine Prävalenz von keywords: aktivität; allem; als; auch; auf; bei; bisher; cfs; chronic; dass; der; des; die; durch; einer; et al; exercise; fatigue; für; hierbei; hiv; ist; kann; mit; nach; oder; sich; sind; sollte; sowie; syndrome; und; von; vor; werden cache: cord-023841-amfb4jft.txt plain text: cord-023841-amfb4jft.txt item: #147 of 549 id: cord-023854-w8kx5n8k author: Schuster, V. title: Virusinfektionen date: 2019 words: 8485 flesch: 42 summary: Diese aktivierten T-Zellen bilden einen großen Anteil der typischen Pfeiffer-Zellen (syn. lymphatische Reizformen, Virozyten) und der teilweise extremen Lymphozytose im In der Mehrzahl der Fälle kommt es hierbei zu einer unterschiedlich ausgeprägten, meist isotonen, selten einer hypertonen Dehydratation. keywords: abb; als; auch; auf; auftreten; bei; bis; blut; cmv; das; dem; der; des; diagnose; die; durch; ebv; eine; erfolgt; fällen; führt; für; hepatitis; herpes; hhv-6; hiv; hsv; häufig; immer; infektion; ist; kann; kindern; kommt; können; meist; mit; mittels; nach; nachweis; nicht; noch; nur; oder; patienten; schweren; sich; sind; sowie; tage; therapie; treten; und; virus; von; vor; vzv; werden; wird; wochen; zellen; zur; über cache: cord-023854-w8kx5n8k.txt plain text: cord-023854-w8kx5n8k.txt item: #148 of 549 id: cord-023884-etkhrgxp author: Meremikwu, Martin title: Malaria in Women and Children date: 2009-05-18 words: 8525 flesch: 41 summary: The role of chemotherapy in malaria control through primary healthcare: constraints and future prospects Cytokine responses to Plasmodium falciparum liver-stage antigen 1 vary in rainy and dry seasons in highland Kenya Measurement of trends in childhood malaria mortality in Africa: an assessment of progress toward targets based on verbal autopsy Malaria attributable to the HIV-1 epidemic, sub-Saharan Africa HIV infection, malaria, and pregnancy: a prospective cohort study in Kigali Malaria in adolescence: burden of disease, consequences, and opportunities for intervention Insecticide-treated bednets and curtains for preventing malaria Effective delivery methods for malaria treatment. 5 What are the challenges of community delivery of malaria treatment through existing primary healthcare systems? keywords: africa; anemia; areas; children; control; falciparum; health; hiv; low; malaria; pregnancy; transmission; treatment; women cache: cord-023884-etkhrgxp.txt plain text: cord-023884-etkhrgxp.txt item: #149 of 549 id: cord-023925-qrr7jcwe author: Verhoef, Jan title: A8 Immune response in human pathology: Infections caused by bacteria, viruses, fungi, and parasites date: 2011-07-12 words: 5501 flesch: 40 summary: Innate immune cells recognise microbes by tolllike receptors (TLR) (see section Pathogenesis of shock), giving rise to the above production of cytokines in the early phase of the response. In particular, the release of TNF-α and interleukin-1 (il-1) after the activation of host cells by endotoxin induces haemodynamic shock. keywords: bacteria; cells; defence; disease; gram; hiv; infections; macrophages; micro; organisms; response; virus; viruses cache: cord-023925-qrr7jcwe.txt plain text: cord-023925-qrr7jcwe.txt item: #150 of 549 id: cord-025172-qg3jxgch author: Covarrubias, Jose title: Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date: 2020-05-24 words: 2819 flesch: 49 summary: key: cord-025172-qg3jxgch authors: Covarrubias, Jose; Grigorian, Areg; Kuza, Catherine M.; Dolich, Matthew; Dosch, Austin; Kojayan, Greg G.; Delaplain, Patrick; Lekawa, Michael; Nahmias, Jeffry title: Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date: 2020-05-24 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01402-4 sha: doc_id: 25172 cord_uid: qg3jxgch BACKGROUND: The Trauma Quality Improvement Program was queried to identify trauma patients ≥ 18 years of age with HIV. keywords: complications; hiv; injury; patients; study; trauma cache: cord-025172-qg3jxgch.txt plain text: cord-025172-qg3jxgch.txt item: #151 of 549 id: cord-025628-9611eglg author: Bonagura, Vincent Robert title: Infections that cause secondary immune deficiency date: 2020-05-29 words: 10027 flesch: 26 summary: This inhibitory signal prevents T cell S-phase entry for several days, and is independent of cell death, membrane fusion, soluble inhibitor production, or T cell infection. Center for Disease Control Substandard vaccination compliance and the 2015 measles outbreak Prospective study of the magnitude and duration of changes in tuberculin reactivity during uncomplicated and complicated measles Cellular immune responses during complicated and uncomplicated measles virus infections of man Cytokine production in vitro and the lymphoproliferative defect of natural measles virus infection Functional and phenotypic changes in circulating lymphocytes from hospitalized zambian children with measles Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8þ cytotoxic T lymphocytes T-lymphocyte subpopulations in relation to immunosuppression in measles and varicella Nonhuman primate models of measles Apoptosis as a cause of death in measles virus-infected cells The dual-function CD150 receptor subfamily: the viral attraction The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively Measles virus infection in rhesus macaques: altered immune responses and comparison of the virulence of six different virus strains Immunologic abnormalities accompanying acute and chronic viral infections Differential CD4 T cell activation in measles Pathogenesis of measles virus infection: an hypothesis for altered immune responses Cytokine imbalance after measles virus infection has no correlation with immune suppression Metabolic effects of acute measles in chronically malnourished Nigerian children -4) and CD30 expression/release during measles infection Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor Differential receptor usage by measles virus strains Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46 Identification of a cytoplasmic Tyr-X-X-Leu motif essential for down regulation of the human cell receptor CD46 in persistent measles virus infection Measles virus haemagglutinin induces down-regulation of gp57/67, a molecule involved in virus binding The cytoplasmic domains of complement regulatory protein CD46 interact with multiple kinases in macrophages Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing Cell-to-cell contact via measles virus haemagglutinin-CD46 interaction triggers CD46 downregulation Receptor usage and differential downregulation of CD46 by measles virus wild-type and vaccine strains Mechanism of suppression of cell-mediated immunity by measles virus Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4þ T cells Activation of human CD4þ cells with CD3 and CD46 induces a Tregulatory cell 1 phenotype In vitro studies of the role of monocytes in the immunosuppression associated with natural measles virus infections Suppression of T lymphocyte function by measles virus is due to cell cycle arrest in G1 Cell cycle arrest rather than apoptosis is associated with measles virus contact-mediated immunosuppression in vitro Measles virus inhibits mitogen-induced T cell proliferation but does not directly perturb the T cell activation process inside the cell Prolonged measles virus shedding in human immunodeficiency virus-infected children, detected by reverse transcriptase-polymerase chain reaction Slow clearance of measles virus RNA after acute infection A novel receptor involved in T-cell activation Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns SLAM) is a receptor for measles virus but is not involved in viral contact-mediated proliferation inhibition Mechanism of CD150 (SLAM) down regulation from the host cell surface by measles virus hemagglutinin protein Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro Measles virus exploits dendritic cells to suppress CD4þ T-cell proliferation via expression of surface viral glycoproteins independently of T-cell trans-infection Measles virus-induced promotion of dendritic cell maturation by soluble mediators does not overcome the immunosuppressive activity of viral glycoproteins on the cell surface Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression Proteolytic cleavage of the fusion protein but not membrane fusion is required for measles virus-induced immunosuppression in vitro Measles virus-induced immunosuppression in cotton rats is associated with cell cycle retardation in uninfected lymphocytes Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins Measles virus interacts with and alters signal transduction in T-cell lipid rafts Disruption of Akt kinase activation is important for immunosuppression induced by measles virus Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation Influenza pandemics of the 20th century Pandemic Flu History keywords: activation; cause; cells; expression; function; hiv; human; il-10; immune; immunity; infection; influenza; leishmaniasis; measles; patients; pertussis; responses; t cells; virus cache: cord-025628-9611eglg.txt plain text: cord-025628-9611eglg.txt item: #152 of 549 id: cord-026112-58sa5z03 author: Dehghani-Dehej, Farzaneh title: Prevalence of HCV and/or HBV coinfection in Iranian HIV-infected patients date: 2020-04-24 words: 4005 flesch: 41 summary: HIV diagnosis and treatment through advanced technologies World Health Organization Global Health Observatory Current diagnostic methods for HIV Interference of apoptosis by hepatitis B virus Characterization of hepatitis B virus with complex structural variations HIV-hepatitis B virus coinfection: epidemiology, pathogenesis, and treatment Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity Hepatitis B: screening, awareness, and the need to treat Hepatitis B virus infection in the general population of Iran: an updated systematic review and meta-analysis Hepatitis C virus (HCV) genotyping by annealing reverse transcription-PCR products with genotype-specific capture probes Identification of a novel hepatitis C virus genotype from Punjab, India: expanding classification of hepatitis C virus into 8 genotypes Molecular epidemiology of hepatitis C virus in Cambodia during 2016-2017 Hepatitis B, hepatitis C, and mortality among HIV-positive individuals Seroprevalence of hepatitis C virus: the first population-based study from Iran The impact of IFN-γ gene polymorphisms on spontaneous clearance of HCV infection in Fars Province, Southern of Iran The presence of autoantibodies to cytoplasmic rod and ring particles in the serum of patients with chronic hepatitis C virus infection Hepatocellular carcinoma after sustained virological response with interferon-free regimens in HIV/hepatitis C virus-coinfected patients HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS) Hepatitis B and long-term HIV outcomes in co-infected HAART recipients Survival in patients with HIV infection and viral hepatitis B or C: a cohort study Management of HIV and hepatitis virus coinfection Human immunodeficiency virus/hepatitis C Virus (HCV) co-infected patients with cirrhosis are no longer at higher risk for hepatocellular carcinoma or end-stage liver disease as compared to HCV mono-infected patients Liver fibrosis and hepatitis B coinfection among ART naive HIV-infected patients at a tertiary level hospital in Northwestern Tanzania: a cross-sectional study Detection of hepatitis B virus covalently closed circular DNA in the plasma of Iranian HBeAg-negative patients with chronic hepatitis B Detection of HBV genome in the plasma and peripheral blood mononuclear cells of Iranian HBsAg negative patients with HIV infection: occult HBV infection Distribution of hepatitis B virus genotypes in azerbaijani patients with chronic hepatitis B infection Prevalence of JC polyomavirus large T antigen sequences among Iranian patients with central nervous system tumors Hepatitis C genotypes in Finland determined by RFLP Occult hepatitis C virus infection in Iranian patients with cryptogenic liver disease Trends in underlying causes of death in people with HIV from Co-infection of human immunodeficiency virus, hepatitis C and hepatitis B virus among injection drug users in Drop in centers Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis Trend of HIV/AIDS prevalence and related interventions administered in Prisons of Iran − 13years' experience Antiretroviral drug resistance mutations in naïve Islamic Republic of Iran AIDS Progress Report HIV-1 genetic diversity and transmitted drug resistance frequency among Iranian treatment-naive, sexually infected individuals Epidemiological distribution and genotype characterization of the hepatitis C virus among HIV patients in Kashan High prevalence of HCV coinfection in HIV-infected individuals in Shiraz, Islamic Republic of Iran Sexually transmitted hepatitis C infection: the new epidemic in MSM? Occasional spontaneous clearance of chronic hepatitis C virus in HIV-infected individuals HIV and HCV coinfection: prevalence, associated factors and genotype characterization in the midwest region of Brazil Prevalence of hepatitis C virus (HCV) coinfection in HIV infected individuals in south India and characterization of HCV genotypes Detection and analysis of hepatitis C virus in HIV-infected patients in the Guangxi province of China Long-term liver diseases after initiation of antiretroviral therapy in HIV-infected patients with and without HBV or HCV coinfection Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level HIV-Hepatitis B virus co-infection: epidemiology, pathogenesis and treatment Isolated antibody to hepatitis B core antigen in human immunodeficiency virus type-1− infected individuals Hepatitis C, hepatitis B, and human immunodeficiency virus infections among non-intravenous drug-using patients attending clinics for sexually transmitted diseases Epidemiology of hepatocellular carcinoma: New trends Prevalence and trend of hepatitis C virus infection among blood donors in Iran: a systematic review and meta-analysis Incidence and residual risk of HIV, HBV and HCV infections among blood donors in Tehran Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study Factors associated with hepatitis B and C co-infection among HIV-infected patients in Singapore Daclatasvir plus sofosbuvir, with or without ribavirin, in real-world patients with HIV-HCV coinfection and advanced liver disease Comparison of demographic, epidemiological, immunological, and clinical characteristics of patients with HIV mono-infection versus patients co-infected with HCV or/and HBV: a Serbian cohort study HBV and HCV coinfection prevalence in Iran-a systematic review and meta-analysis Hepatic decompensation in patients with HIV/hepatitis B Virus (HBV)/hepatitis C Virus (HCV) triple infection versus HIV/HCV coinfection and the effect of anti-HBV nucleos(t)ide therapy HIV infection exacerbates natural history of HCV infection. keywords: hbv; hcv; hepatitis; hiv; infection; patients; positive; rna; virus cache: cord-026112-58sa5z03.txt plain text: cord-026112-58sa5z03.txt item: #153 of 549 id: cord-027242-7qq82j2f author: Chrissafidou, Angeliki title: Infektionen, Impfungen, Reisemedizin date: 2008-12-11 words: 6541 flesch: 49 summary: Notfall kann eine Liste wichtiger Begriffe bezü glich Grav./Geburt in Englisch oder der jeweiligen Sprache des Reiselandes nü tzlich sein Kontraindikationen fü r Reisen in der Schwangerschaft Relativ (abhä ngig von Reiseziel Im ersten Trimenon und 4 Wo. vor der Entbindung Abortneigung, Blutungsneigung. Indikationsimpfungen aufgrund beruflicher Risiken werden von der gesetzlich benannten Stelle (i. d.R. Arbeitgeber) keywords: alle; als; auch; auf; bei; ber; bis; bzw; cave; das; dem; der; des; die; durch; einer; evtl; fieber; fü r; glich; hiv; hren; impfung; impfungen; ist; kann; keine; kinder; klinik; mit; muss; nach; nicht; nur; oder; ohne; pat; prophylaxe; sind; sowie; und; von; vor; wenn; werden; z. b.; zur cache: cord-027242-7qq82j2f.txt plain text: cord-027242-7qq82j2f.txt item: #154 of 549 id: cord-027659-rxbo7b0e author: Bates, Imelda title: Blood Transfusion date: 2020-06-22 words: 4170 flesch: 45 summary: WHO recommendations on SARS and blood safety The risk of malaria transmission by blood transfusion at Cotonou Human immunodefi ciency virus, hepatitis C and hepatitis B infections among blood donors in Germany 2000-2002: risk of virus transmission and the impact of nucleic acid amplifi cation testing Predonation screening of blood donors with rapid tests: implementation and effi cacy of a novel approach to blood safety in resource-poor settings Effect of blood transfusion on survival among children in a Kenyan hospital Trends and risk factors of HIV-1 seropositivity among outpatient children Anaemia, blood transfusion practices, HIV and mortality among women of reproductive age in western Kenya World Health Organization. Those who become infected through blood transfusion are infectious to others and contribute to the spread of disease throughout the wider population. keywords: anaemia; blood; countries; donors; haemoglobin; hepatitis; hiv; malaria; transfusion cache: cord-027659-rxbo7b0e.txt plain text: cord-027659-rxbo7b0e.txt item: #155 of 549 id: cord-027678-k64whepc author: Chan, Kai Man title: Pneumonia date: 2020-06-22 words: 6629 flesch: 35 summary: The role of PCR in diagnosing PCP is mainly limited to non-HIV patients, in whom conventional microscopy and staining of induced sputum and BAL have a lower sensitivity than in HIV patients. The pattern of TB in HIV patients coughs up material containing cysts and trophozoites. keywords: days; diagnosis; disease; guidelines; hiv; icu; infection; management; organisms; patients; pneumonia; sputum; treatment cache: cord-027678-k64whepc.txt plain text: cord-027678-k64whepc.txt item: #156 of 549 id: cord-027859-citynr6c author: P. Shetty, Nandini title: Epidemiology of Disease in the Tropics date: 2020-06-22 words: 9154 flesch: 50 summary: As most patients with such diseases live in developing countries and are too poor to pay for drugs, the pharmaceutical industry has traditionally ignored these diseases. The worldwide eradication of smallpox and the near-eradication of polio from many countries provide excellent examples of the role of immunization in disease control. keywords: africa; asia; burden; cases; children; control; countries; deaths; disease; global; health; hiv; human; infection; malaria; south; world cache: cord-027859-citynr6c.txt plain text: cord-027859-citynr6c.txt item: #157 of 549 id: cord-027860-s97hdhh6 author: Zeimet, Anthony title: Infectious Diseases date: 2020-06-22 words: 28951 flesch: 42 summary: Management of such patients should be coordinated with an infectious diseases specialist, who also should manage drug-resistant TB treatment. Single positive blood culture for Coxiella burnetii or anti-phase 1 IgG antibody titer >1:800 Echocardiogram positive for IE (TEE recommended for patients with prosthetic valves, rated at least possible IE by clinical criteria, or complicated IE [paravalvular abscess]; TTE as first test in other patients) defined as follows: oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation; or abscess; or new partial dehiscence of prosthetic valve; new valvular regurgitation (worsening or changing or preexisting murmur not sufficient) Predisposition, predisposing heart condition, or IDU Fever, temperature >38° C Vascular phenomena, major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway's lesions Immunologic phenomena: glomerulonephritis, Osler's nodes, Roth's spots, and rheumatoid factor Microbiologic evidence: positive blood culture but does not meet a major criterion as noted above * or serological evidence of active infection with organism consistent with IE Echocardiographic minor criteria eliminated Echocardiography should be performed in all patients with suspected infective endocarditis (Baddour et al., 2005) keywords: acute; adults; antibiotics; bacterial; bite; blood; cause; children; chronic; culture; daily; days; diagnosis; diarrhea; discharge; disease; endocarditis; fever; gram; hepatitis; infection; influenza; lesions; months; negative; pain; patients; present; risk; skin; sor; symptoms; testing; therapy; treatment; use; vaccine; virus; weeks; women; wounds cache: cord-027860-s97hdhh6.txt plain text: cord-027860-s97hdhh6.txt item: #158 of 549 id: cord-029416-738t6rk1 author: Mandal, Sandip title: The potential impact of preventive therapy against tuberculosis in the WHO South-East Asian Region: a modelling approach date: 2020-07-20 words: 5179 flesch: 40 summary: Broadly, the relative reductions in TB burden that are achievable by preventive therapy appear greater in those countries with higher TB incidence rates (Table 1 ). Although future strategies will need to be expanded to the population level, to achieve large declines in TB incidence, the uptake of current tools can offer a valuable step in this direction. keywords: household; impact; incidence; model; preventive; region; therapy; tuberculosis cache: cord-029416-738t6rk1.txt plain text: cord-029416-738t6rk1.txt item: #159 of 549 id: cord-029423-o24dthlk author: Iwuji, Collins C. title: A phase IV randomised, open-label pilot study to evaluate switching from protease-inhibitor based regimen to Bictegravir/Emtricitabine/Tenofovir Alafenamide single tablet regimen in Integrase inhibitor-naïve, virologically suppressed HIV-1 infected adults harbouring drug resistance mutations (PIBIK study): study protocol for a randomised trial date: 2020-07-20 words: 6727 flesch: 38 summary: After informed consent, but prior to initiation of study treatment, all SAEs and adverse events related to protocol-mandated procedures would be reported on the CRFs. Following initiation of study treatment, all AEs, regardless of cause or relationship until 30 days post cessation of trial treatment would be reported on the CRFs. keywords: bpi; data; drug; hiv; participants; regimen; resistance; study; taf; tenofovir; treatment; trial; weeks cache: cord-029423-o24dthlk.txt plain text: cord-029423-o24dthlk.txt item: #160 of 549 id: cord-029450-4rnrq78l author: Prattichizzo, Francesco title: Response to: Letter to the Editor on “Bonafè M, Prattichizzo F, Giuliani A, Storci G, Sabbatinelli J, Olivieri F. Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. Cytokine Growth Factor Rev” by Eugenia Quiros-Roldan, Giorgio Biasiotto and Isabella Zanella date: 2020-07-18 words: 1570 flesch: 36 summary: Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes Inflamm-aging: why older men are the most susceptible to SARS-CoV-2 complicated outcomes Clinical features and outcomes of HIV patients with coronavirus disease 2019 A Survey for COVID Among HIV/AIDS Patients in Two Districts of COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19 Induction of a striking systemic cytokine cascade prior to peak viremia in acute human immunodeficiency virus type 1 infection, in contrast to more modest and delayed responses in acute hepatitis B and C virus infections Increased sensitivity of SARS-coronavirus to a combination of human type I and type II interferons Potent inhibition of SARS-associated coronavirus (SCOV) infection and replication by type I interferons (IFN-alpha/beta) but not by type II interferon (IFN-gamma) Synergistic inhibition of SARS-coronavirus replication by type I and type II IFN Treatment with interferon-alpha2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial Ribosomal DNA instability: In regard to this issue, preliminary data from a non-randomized clinical trial suggest a non-significant decrease in mortality in COVID-19 patients treated with the protease inhibitor Lopinavir/Ritonavir [10] . keywords: aging; cov-2; covid-19; patients; sars cache: cord-029450-4rnrq78l.txt plain text: cord-029450-4rnrq78l.txt item: #161 of 549 id: cord-030368-6z99rm0a author: Schwegler, Ute title: Infektionskrankheiten date: 2012 words: 6230 flesch: 40 summary: z Therapie In der Behandlung der In der Zeit der diagnostischen Lücke (Zeitintervall von der Infektion bis zur Antikörperbildung), die bis zu 6 Monaten dauern kann, kommen als direkte Verfahren die PCR und der HIV-p24-Antigentest zur Anwendung. keywords: aber; als; auch; auf; aus; bei; beim; besteht; bewertung; bis; das; dass; dem; den; der; des; deutschland; die; durch; eine; erreger; für; gutachterliche; hiv; impfung; impfungen; infektion; infektionskrankheiten; ist; kann; kommt; können; ländern; mehr; menschen; mit; nach; nicht; nur; oder; regel; seit; selten; sich; sind; stiko; stuhl; therapie; und; verlauf; von; vor; weltweit; werden; wie; wird; wochen; zum; zur; über cache: cord-030368-6z99rm0a.txt plain text: cord-030368-6z99rm0a.txt item: #162 of 549 id: cord-030427-fn9pfqts author: Huang, Feifei title: Acculturation, HIV-Related Stigma, Stress, and Patient-Healthcare Provider Relationships Among HIV-Infected Asian Americans: A Path Analysis date: 2020-08-13 words: 3449 flesch: 39 summary: HIV stigma and stress had a direct, negative effect on patient-HCP relationships. Acculturation had a positive total effect on patient-HCP relationships, and was mediated by HIV stigma and stress. keywords: acculturation; asian; hcp; hiv; patient; relationships; stigma; stress cache: cord-030427-fn9pfqts.txt plain text: cord-030427-fn9pfqts.txt item: #163 of 549 id: cord-031722-n5ja5oqw author: Fields, Errol L. title: Mind the Gap: HIV Prevention Among Young Black Men Who Have Sex with Men date: 2020-09-10 words: 6775 flesch: 32 summary: : peer navigator acceptability among minority MSM in Washington HIV prevention among diverse young MSM: research needs, priorities, and opportunities I am men's health: generating adherence to HIV pre-exposure prophylaxis (PrEP) in young men of color who have sex with men Getting information about HIV prevention: a pilot study I always felt I had to prove my manhood: homosexuality, masculinity, gender role strain, and HIV risk among young Black men who have sex with men There's an app for that: using geosocial networking apps to access young Black gay, bisexual, and other MSM at risk for HIV Technology use and preferences for mobile phone-based HIV prevention and treatment among Black young men who have sex with men: exploratory research Viewpoint: why you should provide HIV pre-exposure prophylaxis (PrEP) at your college health center HIV pre-exposure prophylaxis medication for adolescents and young adults: a position paper of the Society for Adolescent Health and Medicine Advancing independent adolescent consent for participation in HIV prevention research Minors' and young adults' experiences of the research consent process in a phase II safety study of preexposure prophylaxis for HIV Self-consent for HIV prevention research involving sexual and gender minority youth: reducing barriers through evidence-based ethics The influence of age, health literacy, and affluence on adolescents' capacity to consent to research Free testing and PrEP without outing myself to parents: motivation to participate in oral and injectable PrEP clinical trials among adolescent men who have sex with men I won't out myself just to do a survey: sexual and gender minority adolescents' perspectives on the risks and benefits of sex research Parent perspectives about sexual minority adolescent participation in research and requirements of parental permission Methodological considerations for advancing research on the health and wellbeing of sexual and gender minority youth A multicomponent approach to evaluating a pre-exposure prophylaxis (PrEP) implementation program in five agencies in New York Sexual networks of racially diverse young MSM differ in racial homophily but not concurrency Individual and network factors associated with racial disparities in HIV among young men who have sex with men: results from the RADAR Cohort Study Explaining disparities in HIV infection among black and white men who have sex with men: a meta-analysis of HIV risk behaviors The effect of high rates of bacterial sexually transmitted infections on HIV incidence in a cohort of black and white men who have sex with men in The high risk of an HIV diagnosis following a diagnosis of syphilis: a population-level analysis of New York City men Human immunodeficiency virus diagnosis after a syphilis, gonorrhea, or repeat diagnosis among males including non-men who have sex with men: what is the incidence? Rising rates of HIV infection among young US men who have sex with men A data-driven simulation of HIV spread among young men who have sex with men: the role of age and race mixing, and STIs Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion Preexposure prophylaxis for the prevention of HIV infection in the United States-2017 update: a clinical practice guideline The associations of resilience and HIV risk behaviors among Black gay, bisexual, other men who have sex with men (MSM) in the Deep South: the MARI study The impact of racism on child and adolescent health Racial and sexual identities as potential buffers to risky sexual behavior for Black gay and bisexual emerging adult men The relationship between gender role conflict and condom use among black MSM In the past decade, several major advances have emerged in HIV prevention. keywords: adolescent; black; care; health; hiv; men; prep; prevention; prophylaxis; risk; sex; testing; ybmsm; youth cache: cord-031722-n5ja5oqw.txt plain text: cord-031722-n5ja5oqw.txt item: #164 of 549 id: cord-031907-ilhr3iu5 author: None title: ISEV2020 Abstract Book date: 2020-07-15 words: 201435 flesch: 40 summary: Normal pancreas cells (hTERT-HPNE and HPDE-H6c7) were co-cultured with cancer cell EVs for 24-48 hours. Before EV isolation cells were kept for 24 h either under normoxia or hypoxia (1% oxygen). keywords: ability; activation; activity; ad evs; addition; aim; analysis; analysis methods; anti; approach; assay; associated; bacterial evs; biological; biomarkers; blood; blood cells; blood evs; blot; bone; brain; breast; breast cancer; cancer cells; cancer evs; cancer introduction; cancer patients; cd63; cd81; cd9; cell communication; cell culture; cell evs; cell exosomes; cell function; cell lines; cell proliferation; cell surface; cell types; cells; cells introduction; changes; characterization; chromatography; composition; concentration; conclusion; conditions; content; control; control evs; cultured; current; cytometry; data; delivery; density; detection; development; diagnosis; differential; disease; distribution; dna; drug; effect; electron; endothelial; enrichment; epithelial; ev analysis; ev cargo; ev evs; ev isolation; ev markers; ev numbers; ev preparations; ev production; ev protein; ev release; ev research; ev rna; ev samples; ev subpopulations; ev surface; ev treatment; ev uptake; evs; exclusion; exosomal; exosomes; experiments; expression; expression analysis; extracellular; factors; findings; flow; fluorescent; fluorescent evs; fold; formation; fractions; free; function; funding; gene; group; growth; host cells; human; human evs; imaging; immune; increase; inflammation; inflammatory; introduction; isolated; isolation methods; key; large; levels; lipid; lung; macrophages; mass; mechanisms; media; medium; membrane; membrane vesicles; mesenchymal; metastasis; methods; mice; microscopy; migration; milk evs; mirna; model; molecular; molecules; mouse; msc evs; mscs; nanoparticle; national; neuronal; neurons; new; non; normal; novel; nta; number; particles; pathway; patients; plasma evs; plasma samples; platelet; platform; play; positive; positive evs; post; potential; presence; present; primary; process; production; profile; profiling; progression; proliferation; properties; prostate; prostate cancer; protein; protein cargo; protein expression; protein markers; proteomic; purification; purity; range; recipient cells; research; resistance; response; results; rna; rnas; role; samples; sec; secretion; sequencing; serum; sevs; signalling; single; size; small evs; specific; specific evs; spectrometry; stem cells; stromal cells; studies; study; summary; surface; system; target cells; targets; tau; techniques; tested; therapeutic; therapy; time; tissue; total; total evs; tracking; transfer; transmission; treatment; tumour cells; ultracentrifugation; university; uptake; urinary evs; urine; usa; usa introduction; use; vesicles; vesicles introduction; vitro; vivo; work cache: cord-031907-ilhr3iu5.txt plain text: cord-031907-ilhr3iu5.txt item: #165 of 549 id: cord-032438-cpoalxyd author: Nachega, Jean B title: The where, when, and how of community-based versus clinic-based ART delivery in South Africa and Uganda date: 2020-09-21 words: 1287 flesch: 29 summary: In this issue of The Lancet Global Health, Ruanne Barnabas and colleagues report results of the Delivery Optimization of Antiretroviral Therapy (DO-ART) study, a multicentre, randomised trial comparing community-based ART initiation, monitoring, and resupply with use of a hybrid approach (ART initiation at the clinic with community monitoring and resupply), and with standard clinicbased ART delivery among individuals from South Africa and Uganda with detectable HIV viral load. However, most communitybased differentiated service delivery models for ART delivery have been developed for patients who are already stable on ART, and the most important contribution of the study by Barnabas and colleagues is that community-based, same-day ART initiation in individuals with elevated viral load was safe and resulted in improved viral suppression after 12 months, particularly among men. keywords: art; clinic; community; hiv cache: cord-032438-cpoalxyd.txt plain text: cord-032438-cpoalxyd.txt item: #166 of 549 id: cord-032504-tmohg1mj author: Auld, Sara C. title: HIV and the tuberculosis “set point”: how HIV impairs alveolar macrophage responses to tuberculosis and sets the stage for progressive disease date: 2020-09-23 words: 7362 flesch: 25 summary: + cells through interaction with the V H 3 region of IgE Endogenously activated interleukin-4 differentiates disease progressors and non-progressors in tuberculosis susceptible families: a 2-year biomarkers follow-up study Increased Interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis Increased production of interleukin 4 by CD4+ and CD8+ T cells from patients with tuberculosis is related to the presence of pulmonary cavities Role of granulocyte-macrophage colony-stimulating factor production by T cells during Mycobacterium tuberculosis infection Understanding tuberculosis-analyzing the origin of Mycobacterium tuberculosis pathogenicity Human immunodeficiency virus type 1 infection inhibits granulocyte-macrophage colony-stimulating factor-induced activation of STAT5A in human monocyte-derived macrophages Relative levels of M-CSF and GM-CSF influence the specific generation of macrophage populations during infection with Mycobacterium tuberculosis Mycobacterium tuberculosis replicates within necrotic human macrophages IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis Glutathione and infection Mechanisms of control of Mycobacterium tuberculosis by NK cells: role of glutathione Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns Oxidative stress during HIV infection: mechanisms and consequences Anti-retroviral therapy is associated with decreased alveolar glutathione levels even in healthy HIV-infected individuals Glutathione supplementation improves macrophage functions in HIV Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response Redox biology of tuberculosis pathogenesis Mycobacterium tuberculosis induction of heme oxygenase-1 expression is dependent on oxidative stress and reflects treatment outcomes Glutathione-redox balance regulates c-rel-driven IL-12 production in macrophages: possible implications in antituberculosis immunotherapy Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis Glutathione levels and immune responses in tuberculosis patients Liposomal glutathione supplementation restores TH1 cytokine response to Mycobacterium tuberculosis infection in HIV-infected individuals Glutathione and adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals Mycobacterium tuberculosis reactivates HIV-1 via exosome-mediated resetting of cellular redox potential and bioenergetics. 1. Incubation period Tuberculous infection in the light of tuberculin matriculation The time-table of tuberculosis Resistance to tuberculosis: experimental studies in native and acquired defensive mechanism Animal model: experimental airborne tuberculosis in the guinea pig Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection Organ-specific CD4+ T cell response during Listeria monocytogenes infection Progressive pulmonary tuberculosis is not due to increasing numbers of viable bacilli in rabbits, mice and guinea pigs, but is due to a continuous host response to mycobacterial products Immunity to tuberculosis Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection Early Changes by (18)Fluorodeoxyglucose positron emission tomography coregistered with computed tomography predict outcome after Mycobacterium tuberculosis infection in cynomolgus macaques Digitally barcoding Mycobacterium tuberculosis reveals in vivo infection dynamics in the macaque model of tuberculosis Protective immunity against tuberculosis: what does it look like and how do we find it? keywords: cells; control; disease; hiv; human; immunity; infection; macrophages; mtb; mycobacterium; point; response; set; tuberculosis cache: cord-032504-tmohg1mj.txt plain text: cord-032504-tmohg1mj.txt item: #167 of 549 id: cord-033558-lcgo1tiy author: Schmiedel, Stefan title: Infektionen, Impfungen, Reisemedizin date: 2020-10-09 words: 5020 flesch: 46 summary: für alle Fernreisenden; aufgrund der guten Verträglichkeit u. der fast 100-proz. interkurrente Inf. zum Zeitpunkt der Impfung abklären → Serum u. ggf. keywords: alle; als; auch; auf; bei; bzw; das; der; des; die; durch; einer; erkr; evtl; für; hiv; impfstoff; impfung; impfungen; inf; ist; keine; mit; möglich; nach; nicht; nur; prophylaxe; sind; tab; und; von; vor; wenn; werden; zur cache: cord-033558-lcgo1tiy.txt plain text: cord-033558-lcgo1tiy.txt item: #168 of 549 id: cord-034036-1wigu3i3 author: Yu, Changhao title: Current epidemiological and etiological characteristics and treatment of seizures or epilepsy in patients with HIV infection date: 2020-10-21 words: 5859 flesch: 44 summary: Opportunistic infections are a stereotypical predisposing factor for seizures in HIV patients, but a variety of pathogenic factors can also be found in these patients, such as metabolic perturbation and drug-drug interactions. As HIV patients with seizures need to take both antivirals and antiepileptic drugs, the risk of drug-drug interactions is greatly increased, and the side effects of drugs may also become more prominent. keywords: children; drug; epilepsy; hiv; incidence; infection; patients; population; seizures; studies; study cache: cord-034036-1wigu3i3.txt plain text: cord-034036-1wigu3i3.txt item: #169 of 549 id: cord-034269-gqy61g8l author: Abayneh, Kinfe title: Clients’ Satisfaction with Services for Prevention of Mother-to-Child Transmission of HIV in Public Health Facilities in Diredawa City, Eastern Ethiopia date: 2020-10-21 words: 3819 flesch: 49 summary: Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV and syphilis Clients' satisfaction with services for prevention of mother-to-child transmission of HIV in Dodoma Rural district Antiretroviral drugs in the cupboard are not enough: the impact of health systems' performance on mother-to-child transmission of HIV Quality of prevention of mother to child transmission (PMTCT) of HIV services in public hospitals of Hadiya Zone, Southern Ethiopia Prevention of mother-to-child transmission (PMTCT) of HIV services in Adama town, Ethiopia: clients' satisfaction and challenges experienced by service providers HIV testing during pregnancy for prevention of mother-to-child transmission of HIV in Ethiopia Use of UNAIDS tools to evaluate HIV voluntary counselling and testing services for mineworkers in South Africa Utilization of PMTCT services and associated factors among pregnant women attending antenatal clinics in Addis Ababa Assessment of clients' satisfaction with the PMTCT counselling service in Benin city, Edo state, Nigeria Prevention of mother to child transmission of HIV/AIDS: service utilization and associated factors among selected public health facilities in Ethiopia Predictors of patient dissatisfaction with services for prevention of mother-to-child transmission of HIV in Dar es Salaam Utilization of prevention of mother-to-child transmission of HIV services and associated factors among antenatal care attending mothers in Sebeta Town, Central Ethiopia Quality of PMTCT services in gebretsadiq shawo memorial hospital User fees and maternity services in Ethiopia Assessment of client satisfaction in labor and delivery services at a maternity referral hospital in Ethiopia Acceptance of HIV testing among pregnant women in We would like to acknowledge Haramaya University for their technical and financial support of this study. Of the 516 study participants, 424 (82.2%, 95% CI 66.4%-94.3%) clients were satisfied with the PMTCT component of HIV services. keywords: client; counseling; health; hiv; pmtct; satisfaction; services; study cache: cord-034269-gqy61g8l.txt plain text: cord-034269-gqy61g8l.txt item: #170 of 549 id: cord-034714-6e37yylk author: Alleg, Manel title: Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximab- than natalizumab-associated PML date: 2020-11-06 words: 3755 flesch: 30 summary: The proportion of hyposignal seen on T2*-or SWANweighted images at the cortical-subcortical junction adjacent to PML lesions (Fig. 6 ) did not differ between PML groups, in agreement with other studies [15, 21, 24] ; this sign seems nonspecific in PML for the underlying cause of immunosuppression. To compare PML lesions, we described the location (frontal lobe, parietal lobe, occipital lobe, temporal lobe, basal ganglia, supra-or infratentorial or both), involvement of cortex and/or deep GM, distribution (unilobar involving a single lobe, multilobar involving more than one contiguous lobe, widespread involving more than two contiguous lobes or noncontiguous lobes or bilaterality), boundaries (sharp towards WM and GM, ill-defined towards WM and GM), lesion characteristics (aspect on T2-weighted images defined as homogeneous or microcystic corresponding to small lesions in or adjacent to the main PML lesions with an increased signal called the milky way; the presence or absence of a hyposignal on T2*/SWI/SWAN-weighted images, signal on DWI, and Statistical analysis was performed using R software, version 3.1, via the GMRC Shiny Stat application of the Strasbourg University Hospital (2017) and using the XLSTAT software in its Addinsoft 2016 version. keywords: group; hiv; lesions; mri; natalizumab; patients; pml; rituximab cache: cord-034714-6e37yylk.txt plain text: cord-034714-6e37yylk.txt item: #171 of 549 id: cord-048351-4y8ghcpq author: Murdoch, David M title: Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options date: 2007-05-08 words: 5549 flesch: 23 summary: The prevalence and risk of immune restoration disease in HIV-infected patients treated with highly active antiretroviral therapy Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected thai children Paradoxical reactions of tuberculosis in patients with the acquired immunodeficiency syndrome who are treated with highly active antiretroviral therapy Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation Immune dysfunction and immune restoration disease in HIV patients given highly active antiretroviral therapy Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients Incidence of Immune Reconstitution Syndrome in HIV/Tuberculosis-Coinfected Patients After Initiation of Generic Antiretroviral Therapy in India Paradoxical response to antituberculous therapy in immunocompetent patients and HIV co-infected patients Clinical characteristics of IRIS syndrome in patients with HIV and tuberculosis Timing of antiretroviral therapy initiation in tuberculosis patients with AIDS: a decision analysis Military tuberculosis with paradoxical expansion of intracranial tuberculomas complicating human immunodeficiency virus infection in a patient receiving highly active antiretroviral therapy Paradoxical reaction during treatment of tuberculous brain abscess in a patient with Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals Systemic inflammatory reaction after starting highly active antiretroviral therapy in AIDS patients treated for extrapulmonary tuberculosis Symptomatic intracranial tuberculoma developing during treatment of tuberculosis: a report of 10 patients and review of the literature Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV Multiple intracranial tuberculomas with atypical response to tuberculostatic chemotherapy: literature review and a case report Paradoxical presentation of intracranial tuberculomas after chemotherapy in a patient with AIDS Adjunctive corticosteroid therapy for tuberculosis: a critical reappraisal of the literature Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults Zidovudine-induced restoration of cell-mediated immunity to mycobacteria in immunodeficient HIV-infected patients Acute respiratory failure due to Mycobacterium kansasii infection: immune reconstitution disease in a patient with AIDS Borderline tuberculoid leprosy: an immune reconstitution phenomenon in a human immunodeficiency virus-infected person Nontuberculous mycobacterial immune reconstitution syndrome in HIV-infected patients: spectrum of disease and long-term follow-up Localized osteomyelitis due to Mycobacterium avium complex in patients with Human Immunodeficiency Virus receiving highly active antiretroviral therapy Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS) Increased levels of interleukin-6 (IL-6) in IRIS patients may explain the exuberant Th1 response to mycobacterial antigens in subjects with clinical IRIS keywords: art; disease; hiv; initiation; iris; patients; reconstitution; syndrome; therapy; treatment cache: cord-048351-4y8ghcpq.txt plain text: cord-048351-4y8ghcpq.txt item: #172 of 549 id: cord-048467-1dus0u4m author: Civaner, Murat title: Can "presumed consent" justify the duty to treat infectious diseases? An analysis date: 2008-03-06 words: 7746 flesch: 48 summary: Moreover, as described above, the decision to quit medical school can be quite difficult: on one side of the dilemma there are occupational risks that must be accepted regardless of misgivings on the part of the individual; on the other side, very influential factors pressure the individual to continue their medical education. And, needless to say, such risks do indeed at times prove fatal. keywords: care; consent; diseases; duty; hcws; medical; profession; risks cache: cord-048467-1dus0u4m.txt plain text: cord-048467-1dus0u4m.txt item: #173 of 549 id: cord-076081-ue9azoyf author: Hardon, Anita title: Alternative medicines for AIDS in resource-poor settings: Insights from exploratory anthropological studies in Asia and Africa date: 2008-07-10 words: 3403 flesch: 46 summary: They do so for economic reasons: alternative medicines are big business, but they also do so for ideological reasons: neo-traditional medicines reflect an attractive hybrid of modernity and national heritage, providing a sense of national identity in the globalized health economy [10] . [6] presented findings on the supply of what they label neo-traditional medicines to refer to the boundary-crossing nature of these treatments in West Africa. keywords: africa; aids; alternative; health; hiv; medicines; products; treatments cache: cord-076081-ue9azoyf.txt plain text: cord-076081-ue9azoyf.txt item: #174 of 549 id: cord-102905-rlee32x7 author: Leis, Jonathan title: Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells date: 2020-05-04 words: 5784 flesch: 41 summary: Additionally, we designed and synthesized novel prazole analogs that act in the nanomolar range to block virus release, a major step forward in creating a VBI that can be brought to the clinic. In HIV, ESCRT proteins are recruited to virus budding complexes through an interaction between the L-domain (PTAPP motifs) in virus structural proteins (3) (4) (5) (6) (7) with cellular protein Tsg101 (Tumor susceptibility gene 101), a homolog of the E2 ubiquitin conjugating enzyme and a member of the ESCRT-I complex (6, (8) (9) (10) (11) . keywords: budding; cells; compounds; escrt; ilaprazole; particles; prazole; protein; release; tenatoprazole; tsg101; virus cache: cord-102905-rlee32x7.txt plain text: cord-102905-rlee32x7.txt item: #175 of 549 id: cord-103350-jj9pc4a6 author: Tang, Pingtao title: An HIV-Tat inducible mouse model system of childhood HIV-associated nephropathy date: 2020-05-08 words: 4061 flesch: 40 summary: A urinary biomarker profile for children with HIV-associated renal diseases Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes Liver bypass significantly increases the transduction efficiency of recombinant adenoviral vectors in the lung, intestine, and kidney Efficient gene transfer to rat renal glomeruli with recombinant adenoviral vectors Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein Cutting edge: a short polypeptide domain of HIV-1-Tat protein mediates pathogenesis Tat trans-activates the human immunodeficiency virus through a nascent RNA target The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Kidney disease in HIV-positive children HIV-associated kidney glomerular diseases: changes with time and HAART Viral load and HIV-associated nephropathy HIV-associated nephropathy in the setting of maximal virologic suppression Renal disease in children with the acquired immunodeficiency syndrome Human immunodeficiency virus (HIV)-associated nephropathy in children from the HIVassociated nephropathy in transgenic mice expressing HIV-1 genes Nephropathy in HIV-transgenic mice A novel HIV-1 transgenic rat model of childhood HIV-1-associated nephropathy Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy Transgenic and infectious animal models of HIV-associated nephropathy The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin Adenovirus-mediated gene transfer to glomerular cells in newborn mice bFGF and its low affinity receptors in the pathogenesis of HIVassociated nephropathy in transgenic mice HIV-1 upregulates VEGF in podocytes keywords: children; growth; hiv; hivan; kidney; mice; protein; renal; tat cache: cord-103350-jj9pc4a6.txt plain text: cord-103350-jj9pc4a6.txt item: #176 of 549 id: cord-103662-a4ok5wqc author: Tarek, M. title: Custommune: a web tool to design personalized and population-targeted vaccine epitopes date: 2020-04-29 words: 8122 flesch: 40 summary: Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacity Post-therapy viral set-point abatement following combined antiproliferative and immune-boosting interventions: results from a randomised clinical trial The COVID-19 epidemic Evaluation of the establishment of herd immunity in the population by means of serological surveys and vaccination coverage NetMHCpan-4.0: Improved Peptide-MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics Mechanisms of viral mutation BepiPred-2.0: improving sequencebased B-cell epitope prediction using conformational epitopes Chloroquine is a potent inhibitor of SARS coronavirus infection and spread New insights into the antiviral effects of chloroquine Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Hydroxychloroquine and Azithromycin as a treatment of COVID-19: preliminary results of an open-label non-randomized clinical trial Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2 Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes Screening and Identification of Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific CTL Epitopes The $1,000 Genome: The Revolution in DNA Sequencing and the New Era of Personalized Medicine The epidemiological transition: the current status of infectious diseases in the developed world versus the developing world Therapeutic HIV Peptide Vaccine OpenVax: An Open-Source Computational Pipeline for Cancer Neoantigen Prediction How will country-based mitigation measures influence the course of the COVID-19 epidemic? Moreover, the choice of a highly conserved viral target as a source of vaccine epitopes should ensure a broadly effective response in those individuals for whom the vaccine should prove immunogenic. keywords: ace2; alleles; class; cov-2; custommune; design; epitopes; gag; hla; license; population; preprint; sars; sequences; vaccine cache: cord-103662-a4ok5wqc.txt plain text: cord-103662-a4ok5wqc.txt item: #177 of 549 id: cord-104162-fe51v2pt author: Zhang, Chiyu title: Potential Achilles heels of SARS-CoV-2 displayed by the base order-dependent component of RNA folding energy date: 2020-11-02 words: 3746 flesch: 42 summary: [22] were primarily concerned with the statistical significance of RNA folding, rather than with distinguishing the relative contributions of base composition and base order. Just as a local arrangement of words conveys specific meaning to a text, so base order better reflects local evolutionary pressures. keywords: base; composition; folding; genome; order; regions; rna; sars; structure cache: cord-104162-fe51v2pt.txt plain text: cord-104162-fe51v2pt.txt item: #178 of 549 id: cord-104490-t42eccng author: Frimpong, Shadrack title: A Case for Girl-child Education to Prevent and Curb the Impact of Emerging Infectious Diseases Epidemics date: 2020-09-30 words: 4116 flesch: 47 summary: This alignment is especially important because many such rural communities still do not prioritize girl-child education due to persisting cultural beliefs; (3) Community education -the community should be reminded continually of the components, their role in the project's successes, and challenges. For instance, during the HIV/AIDS and recent EVD outbreaks, many young girls had to drop out of school to provide and care for their families who were sick and dying, consequently increasing their risk of exposure to these lethal viruses [13] . keywords: aids; community; education; girls; health; hiv; interventions; outcomes; school cache: cord-104490-t42eccng.txt plain text: cord-104490-t42eccng.txt item: #179 of 549 id: cord-104491-uu2rbtem author: Andiman, Warren A. title: Where Have All the “AIDS Babies” Gone? A Historical Memoir of the Pediatric AIDS Epidemic in New Haven and its Eventual Eradication date: 2020-09-30 words: 8103 flesch: 54 summary: Despite these gains, our pre-eminent wish remained unshaken, i.e. to eradicate MTCT of HIV, a goal that would prevent the life-long morbidities and suffering that accompany pediatric HIV infection and its attendant limitations and stigma. HIV care and obstetric care were linked. keywords: aids; babies; care; children; haven; hiv; hospital; infection; mothers; new; patients; pediatric; percent; positive; program; risk; years cache: cord-104491-uu2rbtem.txt plain text: cord-104491-uu2rbtem.txt item: #180 of 549 id: cord-251939-dvbua4pf author: Nepal, Binod title: AIDS denial in Asia: Dimensions and roots date: 2007-12-31 words: 4951 flesch: 52 summary: key: cord-251939-dvbua4pf authors: Nepal, Binod title: AIDS denial in Asia: Dimensions and roots date: 2007-12-31 journal: Health Policy DOI: 10.1016/j.healthpol.2007.04.011 sha: doc_id: 251939 cord_uid: dvbua4pf Abstract AIDS denial has long been viewed as the obstacle to forging effective response in many Asian countries. AIDS denial is not a new and isolated phenomenon but the one shaped by the global and historical institutions. keywords: aids; asia; countries; denial; disease; groups; hiv; people; risk; sex cache: cord-251939-dvbua4pf.txt plain text: cord-251939-dvbua4pf.txt item: #181 of 549 id: cord-252039-732z92dd author: Valdiserri, Ronald O. title: Responding to Pandemics: What We’ve Learned from HIV/AIDS date: 2020-04-09 words: 2076 flesch: 42 summary: The 1918 influenza epidemic in New York City: a review of the public health response Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic Changing perceptions of pandemic influenza and public health responses How the 1918 Flu Pandemic Revolutionized Public Health. To wit, during a pandemic the goal of public health is to protect the health of the entire population, not just to prevent or treat disease among specific individuals. keywords: disease; health; hiv; pandemic; public cache: cord-252039-732z92dd.txt plain text: cord-252039-732z92dd.txt item: #182 of 549 id: cord-252167-2zxw3sh8 author: Poteat, Tonia C title: Celebrating the struggle against homophobia, transphobia and biphobia as central to ending HIV transmission by 2030 date: 2020-05-14 words: 1255 flesch: 34 summary: While more resource-constrained settings tend to have more restrictive legal contexts secondary to colonialism and ongoing neocolonialism, notably, there is no clear division by geography, income level or development index that separates countries where LGBTI rights are advancing and those where there have been setbacks. As the world grapples with the COVID-19 pandemic, the novel coronavirus is highlighting existing disparities with disproportionate deaths among populations made most vulnerable by structural violence and discrimination, including LGBTI people. keywords: gender; hiv; lgbti; sex cache: cord-252167-2zxw3sh8.txt plain text: cord-252167-2zxw3sh8.txt item: #183 of 549 id: cord-252433-0e9lonq4 author: Cullen, Bryan R. title: Viral RNAs: Lessons from the Enemy date: 2009-02-20 words: 3564 flesch: 48 summary: Although IRES elements were first discovered in RNA viruses, a subset of cellular mRNAs are now known to also contain IRESs. The RRE contains a single, high-affinity Rev-binding site and also functions as a scaffold for the multimerization of Rev on viral mRNAs. keywords: cells; cellular; mrnas; rev; translation; viruses cache: cord-252433-0e9lonq4.txt plain text: cord-252433-0e9lonq4.txt item: #184 of 549 id: cord-253182-s60vzf3q author: Fang, Evandro F. title: A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks date: 2020-09-21 words: 23336 flesch: 37 summary: Rapid ageing and an alarming increase in non-communicable diseases (NCDs) have arisen as major health concerns in China Marten et al., 2014) . Fourthly, a reform of the payment model used in elderly care services should be carried out, focusing on value rather than volume of care for populations at risk of care dependency. keywords: adults; ageing; care; china; chinese; clinical; community; data; dementia; development; diseases; et al; factors; family; fig; frailty; government; health; healthcare; hiv; insurance; level; life; mortality; national; patients; people; population; prevalence; research; risk; sarcopenia; services; society; studies; study; system; treatment; use; years cache: cord-253182-s60vzf3q.txt plain text: cord-253182-s60vzf3q.txt item: #185 of 549 id: cord-253426-s57wuzyg author: Benkovic, Scott title: 4 Cases: HIV and SARS‐CoV‐2 Co‐infection in patients from Long Island, New York date: 2020-05-19 words: 1001 flesch: 61 summary: key: cord-253426-s57wuzyg authors: Benkovic, Scott; Kim, Michelle; Sin, Eric title: 4 Cases: HIV and SARS‐CoV‐2 Co‐infection in patients from Long Island, New York date: 2020-05-19 journal: J Med Virol DOI: 10.1002/jmv.26029 sha: doc_id: 253426 cord_uid: s57wuzyg Originating from Wuhan, China, the novel coronavirus 2019 (SARS‐CoV‐2) has been spreading worldwide since the end of 2019. I Clinical characteristics and outcome of 4 HIV and COVID-19 coinfection Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management Smell dysfunction: a biomarker for COVID-19. keywords: cases; days; hiv cache: cord-253426-s57wuzyg.txt plain text: cord-253426-s57wuzyg.txt item: #186 of 549 id: cord-253556-p1y0zeo1 author: Rhodes, Scott D. title: A rapid qualitative assessment of the impact of the COVID-19 pandemic on a racially/ethnically diverse sample of gay, bisexual, and other men who have sex with men living with HIV in the US South date: 2020-08-12 words: 5503 flesch: 51 summary: This commitment to prevention was noted by other participants. We collected qualitative data from participants who had completed 12 months of participation in and had graduated from the weCare intervention. keywords: african; american; covid-19; health; hiv; impact; living; men; pandemic; participants; plwh; white; years cache: cord-253556-p1y0zeo1.txt plain text: cord-253556-p1y0zeo1.txt item: #187 of 549 id: cord-253768-y35m3vh1 author: Springer, Sandra A title: Federal and State Action Needed to End the Infectious Complications of Illicit Drug Use in the United States: IDSA and HIVMA’s Advocacy Agenda date: 2020-10-01 words: 5850 flesch: 36 summary: Priority issues for IDSA and HIVMA were provisions authorizing funding for the Centers for Disease Control and Prevention (CDC) to eliminate opioid related infections through improved surveillance and prevention for infections linked to IDU and funding for the Health Resources and Services Administration to build workforce capacity through a new Substance Use Treatment Provider Loan Forgiveness Program, offering up to $250 000 in loan repayment over 6 years for providers working in substance use treatment facilities [20] . Only about 5% of the nation's physicians have waivers to prescribe buprenorphine and most substance use treatment programs do not have opioid treatment programs, which makes methadone treatment challenging to obtain [18] . keywords: care; diseases; drug; hcv; health; hiv; infections; opioid; oud; prevention; states; sud; treatment; use cache: cord-253768-y35m3vh1.txt plain text: cord-253768-y35m3vh1.txt item: #188 of 549 id: cord-253997-imwjoecx author: Lotter-Stark, Hester C.T. title: Plant made anti-HIV microbicides—A field of opportunity date: 2012-12-31 words: 12008 flesch: 36 summary: However developments in this arena have resulted in significantly improved state-of-the-art technologies for plant based protein expression. Numerous therapeutic proteins have been produced in plant systems (Giddings et al., 2000; Ma et al., 2003) . keywords: activity; antibodies; antibody; binding; cell; development; et al; expression; glycans; hiv; human; immunodeficiency; lectins; levels; microbicides; plant; production; protein; recombinant; systems; type; vector; virus cache: cord-253997-imwjoecx.txt plain text: cord-253997-imwjoecx.txt item: #189 of 549 id: cord-254098-4imkkptg author: Chutiwitoonchai, Nopporn title: Characteristics of IFITM, the newly identified IFN-inducible anti-HIV-1 family proteins date: 2013-01-30 words: 4358 flesch: 45 summary: These results indicate that IFITMs are resistant to the down-regulation of cell surface expression or the degradation by HIV-1 proteins. Indeed, our results supported the idea that IFITMs interfere with viral protein expression mediated by double-stranded viral RNAs, such as RRE and TAR. keywords: cell; expression; fig; gag; ifitms; nef; plasmid; proteins; tetherin; vif cache: cord-254098-4imkkptg.txt plain text: cord-254098-4imkkptg.txt item: #190 of 549 id: cord-254187-dcdc6sqi author: Kimball, AM title: “What, me worry?” Businesses and AIDS at Davos date: 2005-04-05 words: 1837 flesch: 54 summary: 2 -as it does in many of South Africa's mining companies which, not surprisingly, have pioneered inhouse AIDS treatment. The corporate sector is shouldering more responsibility for the health of its workforce than it ever has in the past, says Bernie Clark of the health-care consulting team of Alexander Forbes, a firm that advises businesses on employee benefits and has helped several companies to develop AIDS policies (Clark B, Alexander Forbes, Johannesburg, South Africa, personal communication). keywords: aids; asia; business; hiv; south cache: cord-254187-dcdc6sqi.txt plain text: cord-254187-dcdc6sqi.txt item: #191 of 549 id: cord-254190-bxfne94u author: Tu, Wenwei title: Application of Humanized Mice in Immunological Research date: 2015-07-07 words: 6266 flesch: 17 summary: Scientists are still improving the humanized mouse model but are optimistic about its future role in evaluating AIDS vaccine candidates Humanized mice as a preclinical tool for infectious disease and biomedical research HLA transgenic mice as humanized mouse models of disease and immunity Prevention of Humanized diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A*0201 Humanized mice for studying human leukocyte integrins in vivo Full reconstitution of human platelets in humanized mice after macrophage depletion Human T cell development in the liver of humanized NOD/SCID/ IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/ liver tissue and hematopoietic stem cells Expression of HLA class II molecules in humanized NOD. Rapid evolution of HIV-1 to functional CD8(+) T cell responses in humanized BLT mice Effi cient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2(-)/(-) gamma C(-)/(-) mice in vivo Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads Engineering HIV-1-resistant T-cells from short-hairpin RNAexpressing hematopoietic stem/progenitor cells in humanized BLT mice An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice Intravital microscopy in BLT-humanized mice to study cellular dynamics in HIV infection Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice Humanized mice for modeling human infectious disease: challenges, progress, and outlook Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing Enhanced humoral and HLA-A2-restricted dengue virus-specifi c T-cell responses in humanized BLT NSG mice Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice Dengue virus tropism in humanized mice recapitulates human dengue fever EBNA3B-defi cient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice Epstein-Barr virus induces erosive arthritis in humanized mice T cells modulate Epstein-Barr virus latency phenotypes during infection of humanized mice Reproduction of Epstein-Barr virus infection and pathogenesis in humanized mice Adoptive transfer of EBV Specifi c CD8+ T cell clones can transiently control EBV infection in humanized mice HCMV infection of humanized mice after transplantation of G-CSF-mobilized peripheral blood stem cells from HCMV-seropositive donors Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection Humanized mice for Salmonella typhi infection: new tools for an old problem Modeling of human herpesvirus infections in humanized mice Human herpesvirus 6A infection and immunopathogenesis in humanized Rag2(-)/(-) gammac(-)/(-) mice Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria Humanized mice, a new model to study the infl uence of drug treatment on neonatal sepsis Humanized mice for the study of infectious diseases Development of a transgenic mouse model susceptible to human coronavirus 229E New generation humanized mice for virus research: comparative aspects and future prospects Infectious diseases in humanized mice Use of humanized severe combined immunodeficient mice for human vaccine development Human immune responses and potential for vaccine assessment in humanized mice Broad infl uenza-specifi c CD8+ T-cell responses in humanized mice vaccinated with infl uenza virus vaccines Humanized mice: are we there yet? Humanized mice: current states and perspectives Humanized mice for immune system investigation: progress, promise and challenges This work was supported in part by the Area of Excellence program supported by the University Grants Committee of the Hong Kong SAR, China (AoE/M-12/06 and AoE/M-06/08). keywords: cells; development; diseases; hla; human; immune; infection; mice; model; mouse; specifi; system; transgenic; virus cache: cord-254190-bxfne94u.txt plain text: cord-254190-bxfne94u.txt item: #192 of 549 id: cord-254194-962vynwk author: Galdiero, Stefania title: Silver Nanoparticles as Potential Antiviral Agents date: 2011-10-24 words: 10043 flesch: 33 summary: Many studies have shown the antimicrobial effects of metal nanoparticles, but the effects of silver nanoparticles against fungal pathogens are mostly unknown; silver nanoparticles, indeed, showed significant antifungal activity against Penicillium citrinum The present review aims at a description of the reported antiviral activities of metal nanoparticles and their production methods, with particular regard to silver nanoparticles. keywords: activity; antiviral; cell; effect; entry; fact; gold; inhibition; interaction; membrane; metal; metal nanoparticles; nanoparticles; silver; surface; synthesis; virus; viruses cache: cord-254194-962vynwk.txt plain text: cord-254194-962vynwk.txt item: #193 of 549 id: cord-254279-7u6ap4g4 author: Zwick, Michael B title: gp41: HIV's shy protein date: 2004 words: 1844 flesch: 51 summary: It will also be useful to elucidate the influence on gp41 structure and function of the segments that were omitted in the gp41 crystal structures. The broadly neutralizing antibodies defined to date seem to recognize gp41 epitopes that are close to the viral membrane but accessible during fusion 14, 15 . keywords: fusion; gp41; structures cache: cord-254279-7u6ap4g4.txt plain text: cord-254279-7u6ap4g4.txt item: #194 of 549 id: cord-254951-anfkuigj author: Pierre, Gashema title: Attendance to HIV Antiretroviral Collection Clinic Appointments During COVID-19 Lockdown. A Single Center Study in Kigali, Rwanda date: 2020-06-25 words: 1218 flesch: 53 summary: Factsheet: global AIDS update Viral suppression in a nationwide sample of HIV-infected children on antiretroviral therapy in Rwanda World Health Organization website COVID-19) situation dashboard Office of the Prime Minister: announcement on enhanced COVID-19 Prevention Measures Sub-Saharan Africa AIDS deaths could double due to COVID-19 2020 Potential effects of disruption to HIV programmes in sub-Saharan Africa caused by COVID-19: results from multiple mathematical models 2020 The consequences of post-election violence on antiretroviral HIV therapy in Kenya Delivering HIV care in challenging operating environments: the MSF experience towards differentiated models of care for settings with multiple basic health care needs Team Rwanda is One of the First Countries to Launch the Differentiated HIV Care Model Nationally It is well-established that without the ability to maintain consistent HIV therapy, some patients face rapid treatment failure. keywords: art; hiv; lockdown; rwanda cache: cord-254951-anfkuigj.txt plain text: cord-254951-anfkuigj.txt item: #195 of 549 id: cord-255075-6azu6k3h author: Zhuang, Jianjian title: Advanced “lab-on-a-chip” to detect viruses – Current challenges and future perspectives date: 2020-05-12 words: 3143 flesch: 23 summary: chip is further combined with the Biological mobile phone, Mobile detection station, or Artificial Intelligence，its potential for virus detection will be extended even further. In the future, microfluidic products that meet the criteria for POC proposed by WHO including (1) 478 being affordable to those at risk of infection, containing (2) high sensitivity, (3) high specificity, (4) 479 user-friendly capabilities, being (5) rapid and robust, (6) equipment free, and (7) Comparison of herpes 603 simplex virus PCR with culture for virus detection in multisource surface swab specimens from 604 neonates Nanoparticle-enhanced electrical detection of Zika virus on paper 607 microchips Improving HIV proteome annotation: new features of BioAfrica HIV Proteomics Resource Multiplexed efficient on-chip sample preparation 613 and sensitive amplification-free detection of Ebola virus Microfluidic 615 System for Detection of Viral RNA in Blood Using a Barcode Fluorescence Reporter Photocleavable Capture Probe Dengue virus: a review on 619 advances in detection and trends -from conventional methods to novel biosensors Differential serum cytokine profiles in patients with chronic hepatitis b, 623 c, and hepatocellular carcinoma The propagation of a Christmas Carol produced by adolescent cancer patients at the Istituto 626 Hands-free smartphone-based diagnostics for simultaneous detection of Zika Dengue at point-of-care Wearable microfluidic diaphragm pressure sensor for health and tactile touch 632 monitoring Microfluidic chips for point-of-care immunodiagnostics Genomic surveillance elucidates Ebola virus origin and 643 transmission during the 2014 outbreak Rapid, low-cost and instrument-free CD4+ cell counting 645 16 for HIV diagnostics in resource-poor settings Prevalence and seasonal distribution of respiratory viruses 647 during the 2014-2015 season in Istanbul The Ebola Epidemic A Global Health Emergency On-chip 651 multiplex electrochemical immunosensor based on disposable 24-site fluidic micro-array screen 652 printing analytical device for multi-component quantitative analysis Point of care diagnostics: status 655 and future Zika virus is a global public health emergency, declares WHO New fronts emerge in the influenza cytokine storm Dengue virus -Mosquito interactions Biology of Zika Virus Infection in Human Skin Cells A multi-virus detectable microfluidic 666 electrochemical immunosensor for simultaneous detection of H1N1, H5N1, and H7N9 virus using ZnO 667 nanorods for sensitivity enhancement Deaths from norovirus 669 among the elderly, England and Wales A comparison study of Zika virus outbreaks 671 in French Polynesia, Colombia and the State of Bahia in Brazil High-throughput and all-solution phase African Swine Fever Virus (ASFV) 674 detection using CRISPR-Cas12a and fluorescence based point-of-care system Traditional and modern cell culture in virus diagnosis. keywords: chip; detection; hiv; paper; point; preparation; sample; system; virus; viruses cache: cord-255075-6azu6k3h.txt plain text: cord-255075-6azu6k3h.txt item: #196 of 549 id: cord-255683-2eq24jth author: Chen, Weizao title: Cross-Reactive Human IgM-Derived Monoclonal Antibodies that Bind to HIV-1 Envelope Glycoproteins date: 2010-02-04 words: 5946 flesch: 40 summary: Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1 Broadly crossreactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1 A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1 Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41 Human monoclonal antibodies and engineered antibody domains as HIV-1 entry inhibitors Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization Correlation between immunologic responses to a recombinant glycoprotein 120 vaccine and incidence of HIV-1 infection in a phase 3 HIV-1 preventive vaccine trial A clinically relevant HIV-1 subunit vaccine protects rhesus macaques from in vivo passaged simian-human immunodeficiency virus infection Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates Antibodies, viruses and vaccines A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope Molecular analysis of HIV-1 gp120 antibody response using isotype IgM and IgG phage display libraries from a long-term non-progressor HIV-1-infected individual A functional human IgM response to HIV-1 Env after immunization with NYVAC HIV C Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses Expression and characterization of a single-chain polypeptide analogue of the human immunodeficiency virus type 1 gp120-CD4 receptor complex Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand The antigenic structure of the HIV gp120 envelope glycoprotein Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody The ability of an oligomeric human immunodeficiency virus type 1 (HIV-1) envelope antigen to elicit neutralizing antibodies against primary HIV-1 isolates is improved following partial deletion of the second hypervariable region Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodies Immunogenicity of DNA vaccines expressing human immunodeficiency virus type 1 envelope glycoprotein with and without deletions in the V1/2 and V3 regions Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response Role of N-linked glycans in a human immunodeficiency virus envelope glycoprotein: effects on protein function and the neutralizing antibody response Modified HIV envelope proteins with enhanced binding to neutralizing monoclonal antibodies Immunogenicity and protective efficacy of oligomeric human immunodeficiency virus type 1 gp140 Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimers Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques Purified complexes of HIV-1 envelope glycoproteins with CD4 and CCR5(CXCR4): production, characterization and immunogenicity Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein Broadly reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz Envelope glycoproteins. Although this approach is being vigorously pursued, none of the immunogens designed has yet efficiently elicited neutralizing antibodies with broad specificity. keywords: antibodies; antibody; binding; chain; envs; figure; gp120; hiv-1; human; infection; neutralizing; virus cache: cord-255683-2eq24jth.txt plain text: cord-255683-2eq24jth.txt item: #197 of 549 id: cord-255690-xc4bxin4 author: Rolain, Jean-Marc title: Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century date: 2007-07-16 words: 7031 flesch: 34 summary: CQ treatment of different cells, including macrophages, could inhibit the growth of several of these intracellular bacteria by neutralising the phagolysosomal pH CQ levels in serum should be monitored to ensure that they are maintained at 1 ± 0.2 mg/L. Similarly, an HIV-infected patient with Q fever endocarditis was successfully treated with valvular replacement and a combination of doxycycline and HCQ [76] . keywords: activity; cells; chloroquine; effect; fever; hcq; human; inhibition; intracellular; patients; treatment; virus; vitro cache: cord-255690-xc4bxin4.txt plain text: cord-255690-xc4bxin4.txt item: #198 of 549 id: cord-255697-trig04hd author: Cheng, Vincent Chi-Chung title: Viral Infections, an Overview with a Focus on Prevention of Transmission date: 2016-10-24 words: 6425 flesch: 32 summary: norovirus shedding time associated with age Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Prevention of nosocomial respiratory syncytial virus infections through compliance with glove and gown isolation precautions Immunization with high-dose intradermal recombinant hepatitis B vaccine in healthcare workers who failed to respond to intramuscular vaccination Epidemiologic study and containment of a nosocomial outbreak of severe acute respiratory Prospective controlled study of four infection-control procedures to prevent nosocomial infection with respiratory syncytial virus Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic An effective quarantine measure reduced the total incidence of influenza A H1N1 in the workplace: another way to control the H1N1 flu pandemic An outbreak of influenza aboard a commercial airliner Efficacy and effectiveness of influenza vaccination Rapid awareness and transmission of severe acute respiratory syndrome in Hanoi French Hospital, Vietnam. As the virus may survive on inanimate surfaces for 12-48 h, and on the surface of hands for 10-15 min (Kampf and Kramer, 2004; Kramer et al., 2006) , influenza virus can be transmitted indirectly by contact with hands from the contaminated environment to the pharyngeal mucosa. keywords: care; control; et al; health; infection; influenza; norovirus; outbreak; patients; sars; transmission; virus; viruses; workers cache: cord-255697-trig04hd.txt plain text: cord-255697-trig04hd.txt item: #199 of 549 id: cord-256324-w3bejmy5 author: Hamada, Yoshio title: New directions for protease inhibitors directed drug discovery date: 2016-07-22 words: 5074 flesch: 51 summary: key: cord-256324-w3bejmy5 authors: Hamada, Yoshio; Kiso, Yoshiaki title: New directions for protease inhibitors directed drug discovery date: 2016-07-22 journal: Biopolymers DOI: 10.1002/bip.22780 sha: doc_id: 256324 cord_uid: w3bejmy5 Proteases play crucial roles in various biological processes, and their activities are essential for all living organisms—from viruses to humans. This makes it possible to design aspartic protease inhibitors logically using a computational approach. keywords: analogue; enzyme; figure; group; inhibitors; protease; secretase; site; state; substrate; transition cache: cord-256324-w3bejmy5.txt plain text: cord-256324-w3bejmy5.txt item: #200 of 549 id: cord-256459-6h358si5 author: Sharpstone, D title: Gastrointestinal manifestations of HIV infection date: 1996-08-10 words: 3646 flesch: 29 summary: 6 In the last review some of the included trials were Acute HIV infection presenting with painful swallowing and esophageal ulcers Natural history and prognosis of diarrhoea of unknown cause in patients with acquired immunodeficiency syndrome (AIDS) Effects of zidovudine treatment on the small intestinal mucosa in patients infected with the human immunodeficiency virus Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine Intestinal mucosal inflammation associated with human immunodeficiency virus infection Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms Duodenal mucosal T cell subpopulation and bacterial cultures in acquired immunodeficiency syndrome Association of gastric hypoacidity with opportunistic enteric infections in patients with AIDS Decreased gastric acid secretion and bacterial colonisation of the stomach in severely malnourished Bangladeshi children Prevalance of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome Infectious diarrhea in patients with AIDS Gastrointestinal symptoms in patients infected with human immunodeficiency virus: relevance of infective agents isolated from gastrointestinal tract Prevalence of intestinal protozoans in French patients infected with AIDS Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation Faecal tumour necrosis factor-alpha in HIV-related diarrhoea The diagnosis of AIDS-related chronic diarrhoea: a prospective study in 155 patients Light and electron microscopic appearances of pathological changes in HIV gut infection Enterotoxic effect of stool supernatant of Cryptosporidium-infected calves on human jejunum Jejunal water and electrolyte transport in AIDS-related cryptosporidiosis Small bowel transit in HIVseropositive individuals Autonomic denervation in jejunal mucosa of homosexual men infected with HIV Loss of mucosal CD4 lymphocytes is an early feature of HIV infection Mechanisms of innate and acquired resistance to Cryptosporidium parvum infection in SCID mice Cryptosporidium infection in an adult mouse model: independent roles for IFN-â�¥ and CD4+ T lymphocytes in protective immunity Faecal tumour necrosis factor-alpha and faecal alpha-one-antitrypsin in HIV infection Diarrhoea in HIV-infected patients: no evidence of cytokine-mediated inflammation in jejunal mucosa An algorithm for the investigation of diarrhoea in HIV infection Use of the fluorochrome Calcofluor white in the screening of stool specimens for spores of microsporidia Salmonella, campylobacter and shigella in HIV positive patients Gastrointestinal viral infections in homosexual men who were symptomatic and seropositive for human immunodeficiency virus Efficient management of diarrhea in the acquired immunodeficiency syndrome (AIDS): a medical decision analysis Cytomegalovirus in AIDS: presentation in 44 patients and a review of the literature Spectral and sequence similarity between vasoactive intestinal peptide and the second conserved region of human immunodeficiency virus type 1 envelope glycoprotein (gp 120): possible consequences on prevention and therapy of AIDS Elevated plasma levels of vasoactive intestinal peptide in AIDS patients with refractory idiopathic diarrhea: effects of treatment with octreotide Octreotide therapy of large volume refractory AIDS-associated diarrhea: a randomized controlled trial Treatment with albendazole for intestinal disease due to Enterocytozoon bieneusi in patients with AIDS Thalidomide for microsporidiosis Atrovaquone is effective treatment for the symptoms of gastrointestinal microsporidiosis in HIV-1 infected patients Paromomycin for cryptosporidiosis in AIDS: a Health Information Research Unit Intestinal function and injury acquired immunodeficiency syndrome-related cryptosporidiosis Infective dose size studies on Cryptosporidium parvum using gnotobiotic lambs However, there is a consistent increase in small-bowel permeability in HIV-seropositive individuals; 5 this functional abnormality and the minor structural abnormalities of the small bowel mucosa may be due to the immunological changes produced by HIV infection of lamina propria lymphocytes. keywords: adherence; aids; diarrhoea; hiv; immunodeficiency; individuals; infection; patients; treatment cache: cord-256459-6h358si5.txt plain text: cord-256459-6h358si5.txt item: #201 of 549 id: cord-256477-dftt5m6i author: Feller, John M. title: Potential Ebola prophylaxis date: 2015-07-01 words: 605 flesch: 44 summary: Pandemic paranoia: a heretical view of Ebola and other infectious threats Induction of apoptosis in peripheral blood lymphocytes following treatment in vitro with hydroxychloroquine Inhibition of human immunodeficiency virus type 1 replication by hydroxychloroquine in T cells and monocytes HIV status and delayed type hypersensitivity skin testing Cord blood chloroquine levels and HIV transmission in Ugandan infants Ebola virus VP24 targets a unique NLS Binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1 Reduction of immune activation with chloroquine therapy during chronic HIV infection Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Ebola works in part by inhibiting interferon: an Ebola protein, VP24, binds to and blocks a transport protein on the surface of immune cells that plays an important role in the interferon pathway. keywords: ebola; hiv cache: cord-256477-dftt5m6i.txt plain text: cord-256477-dftt5m6i.txt item: #202 of 549 id: cord-256786-7gca01lr author: Bartilotti‐Matos, F title: Pearls and Pitfalls: two contrasting HIV diagnoses in the COVID‐19 era and the case for screening date: 2020-08-13 words: 1316 flesch: 52 summary: Clinical characteristics and outcomes in people living with HIV hospitalized for COVID-19 COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients Coronavirus disease 2019 (COVID-19) outcomes in HIV/AIDS patients: a systematic review Clinical features and outcomes of HIV patients with coronavirus disease 2019 COVID-19 in patients with HIV: clinical case series Recovery from COVID-19 in two patients with coexisted HIV infection HIV in the United Kingdom: key: cord-256786-7gca01lr authors: Bartilotti‐Matos, F; Davies, P. title: Pearls and Pitfalls: two contrasting HIV diagnoses in the COVID‐19 era and the case for screening date: 2020-08-13 journal: J Med Virol DOI: 10.1002/jmv.26428 sha: doc_id: 256786 cord_uid: 7gca01lr The risk of coronavirus disease 2019 (COVID‐19) for people living with HIV (PLWH) is poorly understood. keywords: case; covid-19; hiv; patients cache: cord-256786-7gca01lr.txt plain text: cord-256786-7gca01lr.txt item: #203 of 549 id: cord-257217-f9sdt7ax author: Nunes, Marta C. title: Clinical Epidemiology of Bocavirus, Rhinovirus, Two Polyomaviruses and Four Coronaviruses in HIV-Infected and HIV-Uninfected South African Children date: 2014-02-03 words: 4642 flesch: 37 summary: A role for Streptococcus pneumoniae in virusassociated pneumonia Respiratory viral and pneumococcal coinfection of the respiratory tract: implications of pneumococcal vaccination A new virus isolated from the human respiratory tract Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease A newly discovered human pneumovirus isolated from young children with respiratory tract disease Cloning of a human parvovirus by molecular screening of respiratory tract samples Identification of a new human coronavirus Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia Identification of a third human polyomavirus A newly reported human polyomavirus, KI virus, is present in the respiratory tract of Australian children Identification of a novel polyomavirus from patients with acute respiratory tract infections The role of rhinovirus in asthma exacerbations Rhinovirus viremia in children with respiratory infections Differing manifestations of respiratory syncytial virus-associated severe lower respiratory tract infections in human immunodeficiency virus type 1-infected and uninfected children Increased burden of respiratory viral associated severe lower respiratory tract infections in children infected with human immunodeficiency virus type-1 Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infection Contribution of common and recently described respiratory viruses to annual hospitalizations in children in South Africa Human polyomaviruses, WU and KI in HIV exposed children with acute lower respiratory tract infections in hospitals in South Africa Pneumococcal coinfection with human metapneumovirus A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection Evaluation of NucliSens easyMAG for automated nucleic acid extraction from various clinical specimens Development of the Respiratory Index of Severity in Children (RISC) score among young children with respiratory infections in South Africa Viral acute respiratory infections among infants visited in a rural hospital of southern Mozambique Accepted for publication) Clinical epidemiology of newly discovered respiratory viruses in HIV-infected and HIVuninfected South African children A preliminary study of pneumonia etiology among hospitalized children in Kenya Viral etiology of severe pneumonia among Kenyan infants and children Human coronavirus NL63 associated with lower respiratory tract symptoms in early life Epidemiology of multiple respiratory viruses in childcare attendees Human respiratory coronavirus HKU1 versus other coronavirus infections in Italian hospitalised patients Detection of four human coronaviruses in respiratory infections in children: a one-year study in Colorado Clinical assessment and improved diagnosis of bocavirus-induced wheezing in children Rationale and expectations of the Pneumonia Etiology Research for Child Health (PERCH) study The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children Prevention (2012) Severe coinfection with seasonal influenza A (H3N2) virus and Staphylococcus aureus-Maryland Furthermore, respiratory viral infections may heighten the susceptibility to developing a super-imposed bacterial infection resulting in severe pneumonia keywords: children; hiv; infections; lrti; study; viral; viruses cache: cord-257217-f9sdt7ax.txt plain text: cord-257217-f9sdt7ax.txt item: #204 of 549 id: cord-257272-4q52p1pd author: Marsh, Mark title: Roles for endocytosis in lentiviral replication date: 1997-01-31 words: 2388 flesch: 42 summary: The cytoplasmic domains of HIV and SIV Env contain several such1 sequences that could potentially act as sorting signals, and studies in polarized cells indicate that Env does contain sorting information 19. Thus, the presence of endocytosis signals that actively clear Env from the plasma membrane appears counterintuitive. keywords: cd4; cell; endocytosis; env; hiv; surface cache: cord-257272-4q52p1pd.txt plain text: cord-257272-4q52p1pd.txt item: #205 of 549 id: cord-257553-479x7av6 author: Kortepeter, Mark G. title: Health Care Workers and Researchers Traveling to Developing-World Clinical Settings: Disease Transmission Risk and Mitigation date: 2010-12-01 words: 3971 flesch: 36 summary: Most HCWs are not counseled regarding tuberculosis risks before departure, nor are they evaluated on their return. There are conflicting opinions regarding the importance of airborne transmission of influenza viruses in humans keywords: exposure; health; hiv; infection; influenza; risk; transmission; treatment; tuberculosis; virus; viruses cache: cord-257553-479x7av6.txt plain text: cord-257553-479x7av6.txt item: #206 of 549 id: cord-258167-jqm3qyfm author: Zhou, Peng title: Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins date: 2009-09-18 words: 2338 flesch: 50 summary: The SARS-CoV S protein (S SARS ) is responsible for virus entry and induction of neutralizing antibodies, mediated mainly by the RBD at aa 318-510 Therefore, for the development of differential diagnosis and specific vaccines for these viruses, it is necessary and important to have a better understanding of the immunogenicity of S SL , S SARS and the difference between S SL and S SARS . keywords: cov; hiv; sars; sera cache: cord-258167-jqm3qyfm.txt plain text: cord-258167-jqm3qyfm.txt item: #207 of 549 id: cord-259131-36udb7uc author: Hunegnaw, Ruth title: Alveolar Macrophage Dysfunction and Increased PD-1 Expression During Chronic SIV Infection of Rhesus Macaques date: 2019-07-03 words: 7487 flesch: 38 summary: Here, using the SIV rhesus macaque model, we document the effect of SIV infection on the phenotypic and functional properties of AMs. These findings provide new insight into the dynamics of SIV infection leading to AM dysfunction and alteration of pulmonary innate immunity. keywords: ams; bal; cells; expression; figure; hiv; infection; macaques; macrophages; naïve; pd-1; siv; wpi cache: cord-259131-36udb7uc.txt plain text: cord-259131-36udb7uc.txt item: #208 of 549 id: cord-259233-smmhhroe author: de Armas‐Rillo, Laura title: Membrane dynamics associated with viral infection date: 2016-01-28 words: 7119 flesch: 35 summary: ASFVs are thought to reorganize cell membranes through viral proteins that contain a KDE motif, inducing the redistribution of ERassociated proteins [88] and the viral p54 protein. Modification of intracellular membrane structures for virus replication Viruses and endosome membrane dynamics When autophagy meets viruses: a double-edged sword with functions in defense and offense Viral infection: moving through complex and dynamic cell-membrane structures How to get out: ssRNA enveloped viruses and membrane fission Neutrophil granules and secretory vesicles in inflammation A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication. keywords: assembly; autophagy; budding; cell; complex; escrt; figure; formation; infection; membrane; proteins; replication; rna; vesicles; virus; viruses cache: cord-259233-smmhhroe.txt plain text: cord-259233-smmhhroe.txt item: #209 of 549 id: cord-259237-aty0vrat author: Frabutt, Dylan A. title: Arms Race between Enveloped Viruses and the Host ERAD Machinery date: 2016-09-19 words: 9844 flesch: 38 summary: Transmembrane control of HRD1P by HRD3P Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L Usa1 functions as a scaffold of the HRD-ubiquitin ligase The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-IV) Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast IRE1 then activates the transcription factor X-Box Binding Protein 1 (XBP-1), which in turn up-regulates ER chaperones to assist in the folding capacity of the ER as well as ERAD components to boost protein degradation. keywords: associated; cell; complex; control; degradation; endoplasmic; envelope; erad; ermani; expression; folding; glycoproteins; man; membrane; pathway; protein; quality; reticulum; stress; virus; viruses cache: cord-259237-aty0vrat.txt plain text: cord-259237-aty0vrat.txt item: #210 of 549 id: cord-259503-dkfrk71a author: Smith, Sarah E. title: Sherlock Genomes — viral investigator date: 2013-02-15 words: 809 flesch: 48 summary: Nat Rev Microbiol DOI: 10.1038/nrmicro2979 sha: doc_id: 259503 cord_uid: dkfrk71a This month's Genome Watch highlights how deep sequencing technologies have vastly reduced the time and prior knowledge needed to generate viral genomes. Even when almost nothing is known about the agent of a viral infection, deep sequencing technologies can identify a pathogen and produce the full genome, fast. keywords: cov; genome; sequencing cache: cord-259503-dkfrk71a.txt plain text: cord-259503-dkfrk71a.txt item: #211 of 549 id: cord-259748-x7dq1sy4 author: Wan, Dongshan title: Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response date: 2020-04-28 words: 14188 flesch: 26 summary: As innate immune cells, DCs have essential roles in antigen presentation, cytokine secretion, and priming the adaptive response of immune cells (176) . Subsequently, it was found that some DNA sensors can facilitate STING activation, such as interferon gamma inducible protein 16 (IFI16) (7) . keywords: activation; autophagy; binding; cancer; cells; cellular; cgamp; cgas; cyclic; cytosolic; dna; dsdna; expression; ifn; immune; immunity; inflammation; interferon; irf3; pathway; protein; response; sensing; sensor; signaling; sting; tbk1; tumor; type; virus cache: cord-259748-x7dq1sy4.txt plain text: cord-259748-x7dq1sy4.txt item: #212 of 549 id: cord-259846-oxbmtend author: Naik, Parvaiz Ahmad title: Global dynamics of a fractional order model for the transmission of HIV epidemic with optimal control date: 2020-06-18 words: 8471 flesch: 46 summary: [34] provided a class of fractional order differential models of biological systems with memory, such as dynamics of tumor-immune system and dynamics of HIV infection of CD4 + T cells. The purpose of dealing with fractional order systems is the memory and hereditary properties which are the complex behav-ioral patterns of biological systems gives us more realistic way to model HIV/AIDS systems. keywords: control; disease; epidemic; fractional; hiv; individuals; model; numerical; order; population cache: cord-259846-oxbmtend.txt plain text: cord-259846-oxbmtend.txt item: #213 of 549 id: cord-259925-g28sx9qu author: Saleemi, Mansab Ali title: Emergence and molecular mechanisms of SARS-CoV-2 and HIV to target host cells and potential therapeutics date: 2020-10-06 words: 6884 flesch: 36 summary: The dramatic reduction in the peripheral CD4+ and CD8+ T cells is one of the symptoms in COVID-19 cases related to HIV infection Diao et al., 2020) . Therefore, this review reflects the latest repurpose of existing antiviral therapeutic drug choices available to combat SARS-CoV-2. Coronaviruses (CoVs) are a group of enveloped and positive single-stranded RNA genome viruses that infect both animals and humans (Smith and Denison, 2013; Xu et al., 2020) . keywords: cd4; cells; coronavirus; cov-2; covid-19; et al; hiv; human; infected; novel; patients; sars; syndrome; transmission; virus cache: cord-259925-g28sx9qu.txt plain text: cord-259925-g28sx9qu.txt item: #214 of 549 id: cord-260071-z29b30sd author: Zhong, Yu title: Highly potent anti-HIV-1 activity isolated from fermented Polygonum tinctorium Aiton date: 2005-03-27 words: 5490 flesch: 54 summary: Sukumo extract, and exhibited anti-viral activity with an EC 50 value of 11.56 g/ml. Sukumo extract was found to interact with both the viral envelope glycoprotein and cellular receptors, thus blocking virus-cell binding and virus-induced syncytium formation. keywords: activity; anti; cells; entry; extract; hiv; p24; sukumo; virus cache: cord-260071-z29b30sd.txt plain text: cord-260071-z29b30sd.txt item: #215 of 549 id: cord-260191-0u0pu0br author: Haas, W. title: „Emerging Infectious Diseases“: Dengue-Fieber, West-Nil-Fieber, SARS, Vogelgrippe, HIV date: 2004-05-29 words: 2438 flesch: 44 summary: [19] .Diese bestehen zum einen in der frühzeitigen Identifizierung von Kontaktpersonen und gegebenenfalls in der Absonderung von Personen nach einem festgelegten Schema. In Deutschland werden derzeit Blutund Plasmaspender von der Spende zurückgestellt, wenn sie sich zwischen keywords: als; auf; bei; den; dengue; der; die; durch; eine; für; hiv; infektion; influenza; ist; mit; nach; sars; sich; sind; und; von; werden cache: cord-260191-0u0pu0br.txt plain text: cord-260191-0u0pu0br.txt item: #216 of 549 id: cord-260422-z22t57ju author: Godet, Julien title: Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1 date: 2012-06-26 words: 9194 flesch: 29 summary: Later, a similar chaperone activity was shown for the HIV-1 NC protein (Darlix et al., 1990; De Rocquigny et al., 1992; Barat et al., 1993; Dib-Hajj et al., 1993; Lapadat-Tapolsky et al., 1993) . In sharp contrast to NCp7, multimerization of Gag or Gag-related proteins dramatically compromises reverse transcription since the cooperative binding and the slow dissociation rate of the multimerized Gag proteins impaired RT processivity (Wu et al., 2010) . keywords: acid; activity; annealing; binding; chaperone; dna; et al; gag; human; ncp7; nucleic; primer; protein; rna; strand; tat; transcription; trna; virus cache: cord-260422-z22t57ju.txt plain text: cord-260422-z22t57ju.txt item: #217 of 549 id: cord-260444-ooi5x9p3 author: Gadelha Farias, Luís Arthur Brasil title: Case Report: Coronavirus Disease and Pulmonary Tuberculosis in Patients with Human Immunodeficiency Virus: Report of Two Cases date: 2020-08-18 words: 2072 flesch: 54 summary: HIV patients with MTB latent infection have a higher risk of reactivation. In this context, the impact of COVID-19 on HIV viral replication in HIV patients with MTB latent infection and in patients with HIV and active TB must be subjects of research. keywords: cov-2; covid-19; hiv; mtb; patients; sars; treatment cache: cord-260444-ooi5x9p3.txt plain text: cord-260444-ooi5x9p3.txt item: #218 of 549 id: cord-260476-whfyczcj author: Seissler, Tanja title: Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins date: 2017-10-31 words: 9536 flesch: 39 summary: Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases The HIV-1 accessory protein Vpr induces the degradation of the anti-HIV-1 agent APOBEC3G through a VprBP-mediated proteasomal pathway The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages HIV-1 Vpr protein Enhances proteasomal degradation of MCM10 DNA replication factor through the Cul4-DDB1[VprBP] E3 ubiquitin ligase to induce G2/M cell cycle arrest HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP HIV-1 Vpr protein induces proteasomal degradation of chromatin-associated class I HDACs to overcome latent infection of macrophages The ubiquitin-proteasome system in HIV replication: Potential targets for antiretroviral therapy Inhibition of Vpx-mediated SAMHD1 and Vpr-mediated host helicase transcription factor degradation by selective disruption of viral CRL4 (DCAF1) E3 ubiquitin ligase assembly On the one hand, the UPS can be used by the cell to degrade viral proteins, thereby restricting the viral infection. keywords: cell; degradation; factor; figure; hiv; ligase; proteasome; protein; restriction; samhd1; trim5α; ubiquitin; ups; vif; vpu cache: cord-260476-whfyczcj.txt plain text: cord-260476-whfyczcj.txt item: #219 of 549 id: cord-260496-s2ba7uy3 author: Moncany, Maurice L.J. title: Identification of conserved lentiviral sequences as landmarks of genomic flexibility date: 2006-08-08 words: 5998 flesch: 48 summary: A likelihood method for the detection of selection and recombination using nucleotide sequences In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity A novel exploratory method for visual recombination detection Scanning the database for recombinant HIV-1 genomes Characterization of a highly replicative intergroup M/O human immunodeficiency virus type 1 recombinant isolated from a Cameroonian patient Sequence variability of the integrase protein from a diverse collection of HIV type 1 isolates representing several subtypes High prevalence of diverse forms of HIV-1 intersubtype recombinants in Central Myanmar: geographical hot spot of extensive recombination Development and application of a highthroughput HIV type-1 genotyping assay to identify CRF02_AG in West/West Central Africa Stepwise detection of recombination breakpoints in sequence alignments Sequencing and comparison of yeast species to identify genes and regulatory elements Genetic characterization of the nef gene from human immunodeficiency virus type 1 group M strains representing genetic subtypes A Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China Genotypic and phenotypic analysis of HIV type 1 primary isolates from western Cameroon Human immunodeficiency virus type 1 recombination: rate, fidelity, and putative hot spots V118I substitution in the reverse transcriptase gene of HIV type 1 CRF02_AG strains infecting drug-naive individuals in Cameroon HIV type-1 circulating recombinant form CRF09_cpx from west Africa combines subtypes A, F, G, and may share ancestors with CRF02_AG and Z321 Isolation and characterization of a fulllength molecular DNA clone of Ghanaian HIV type 1 intersubtype A/G recombinant CRF02_AG, which is replication competent in a restricted host range Emergence of new forms of human immunodeficiency virus type 1 intersubtype recombinants in central Myanmar Independent introduction of transmissible F/D recombinant HIV-1 from Africa into Belgium and The Netherlands Mother-to-child HIV type-1 transmission in Argentina: BF recombinants have predominated in infected children since the mid-1980s Identification of Ugandan HIV type-1 variants with unique patterns of recombination in pol involving subtypes A and D Evolution and diversity of HIV-1 in Africa -a review Prevalence and origin of HIV-1 group M subtypes among patients attending a Belgian hospital in 1999 Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. keywords: cls; clss; gag; gene; genomes; hiv; pol; recombination; sequences; type; viruses cache: cord-260496-s2ba7uy3.txt plain text: cord-260496-s2ba7uy3.txt item: #220 of 549 id: cord-260604-lz1qd69t author: Singh, Ramendra K. title: Synthesis, structure–activity relationship and antiviral activity of 3′-N,N-dimethylamino-2′,3′-dideoxythymidine and its prodrugs date: 2010-09-30 words: 3098 flesch: 52 summary: Molecular docking studies with HIV-1 RT using DS 2.5 and pymol softwares have shown marked differences in the interaction patterns between the lead compound 4 and AZT. HIV-1 reverse transcriptase (HIV-1 RT), a primary target for developing anti-HIV drugs, is the enzyme responsible for generating linear dsDNA from ssRNA e the genetic material of HIV-1. keywords: activity; cell; compound; hiv; lead cache: cord-260604-lz1qd69t.txt plain text: cord-260604-lz1qd69t.txt item: #221 of 549 id: cord-260695-qwepi0we author: Postler, Thomas S. title: Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection date: 2017-11-01 words: 6331 flesch: 45 summary: Specific examples include influenza A virus (IAV), hepatitis C virus, severe acute respiratory syndrome-related coronavirus, adenovirus, herpes simplex virus 1 (HSV-1), human cytomegalovirus, and HIV-1 (Carnero et al., 2016; Chang et al., 2011; Hu et al., 2016; Ouyang et al., 2015; Peng et al., 2010 Peng et al., , 2014 Trypsteen et al., 2016; Winterling et al., 2014; Zhang et al., 2016; Zhao et al., 2016) . In this report, we describe a meta-analysis of two independent RNA-seq studies of HIV-1-infected cells and show that, unexpectedly, only three lncRNAs are differentially expressed in both of these datasets (Chang et al., 2011; Mohammadi et al., 2013) . keywords: cells; data; et al; expression; fig; human; infection; jurkat; levels; linc00173; lnc173; lncrnas; rna; transcripts cache: cord-260695-qwepi0we.txt plain text: cord-260695-qwepi0we.txt item: #222 of 549 id: cord-261287-l4649du3 author: Puoti, Massimo title: A randomized, controlled trial of triple antiviral therapy as initial treatment of chronic hepatitis C in HIV-infected patients() date: 2004-05-06 words: 3685 flesch: 37 summary: (PEG-IFN) plus ribavirin (RBV) vs. PEG-IFN for treatment of HIV/HCV co-infected patients ANRS HC02-RIBAVIC: a randomised controlled trial of pegylatedinterferona-2b plus ribavirin vs interferona-2b plus ribavirin as primary treatment of chronic hepatitis C in HIV co-infected patients Is an 'À la Carte' combination Interferon Alfa-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C? Retreatment with interferon plus ribavirin of chronic hepatitis C non-responders to interferon monotherapy: a metaanalysis of individual patient data Gamma-Glutamyl transpeptidase as a response predictor when using alpha-interferon to treat hepatitis C Treatment of chronic sporadic-type non-A, non-B hepatitis with lymphoblastoid interferon: gamma GT levels predictive for response Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity As we enter an era in which HCV treatment is going to be pursued aggressively in HIV/HCV-co-infected persons, more and more emphasis must be placed on identifying at an early stage subjects who will not benefit from an expensive and poorly tolerated therapy. keywords: chronic; hcv; hepatitis; hiv; interferon; patients; ribavirin; treatment cache: cord-261287-l4649du3.txt plain text: cord-261287-l4649du3.txt item: #223 of 549 id: cord-261382-cyty5noi author: Goffinet, Christine title: Cellular Antiviral Factors that Target Particle Infectivity of HIV-1 date: 2016-05-17 words: 4090 flesch: 30 summary: The IFITM Proteins Inhibit HIV-1 Infection The N-terminal region of IFITM3 modulates its antiviral activity by regulating IFITM3 cellular localization HIV-1 mutates to evade IFITM1 restriction The C-terminal sequence of IFITM1 regulates its anti-HIV-1 activity IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity IFITM proteins restrict viral membrane hemifusion IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients Importance of the nef gene for maintenance of high virus loads and for development of AIDS Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis Quantitation of human immunodeficiency virus type 1 infection kinetics Semen-derived amyloid fibrils drastically enhance HIV infection Quantification of infectious HIV-1 plasma viral load using a boosted in vitro infection protocol This work was supported by grants from the DFG (Collaborative Research Center 900: Microbial Persistence and its Control), from the Helmholtz Center of Infection Research, and from the Margarete von Wrangell Habilitation Program to CG. Another long-appreciated activity of Nef is the enhancement of HIV-1 particle infectivity. keywords: cell; expression; ifitm; infection; infectivity; nef; proteins; type; viral; virus cache: cord-261382-cyty5noi.txt plain text: cord-261382-cyty5noi.txt item: #224 of 549 id: cord-261830-5o5epn6v author: Rheinemann, Lara title: Virus Budding date: 2020-08-07 words: 7042 flesch: 35 summary: In the best-studied cases such as HIV-1, multiple different mammalian ESCRT-III proteins have been shown to localize to the bud neck (Jouvenet et al., 2011) , but only CHMP2 and CHMP4 family members seem to perform indispensable functional roles (Sandrin and Sundquist, 2013; Morita et al., 2011) . These extracellular vesicles resemble exosomes, and viruses that use this egress method are termed quasi-enveloped (Feng et al., 2014) . keywords: assembly; budding; cell; envelope; escrt; et al; fission; gag; iii; membrane; pathway; plasma; proteins; release; virion; virus; viruses cache: cord-261830-5o5epn6v.txt plain text: cord-261830-5o5epn6v.txt item: #225 of 549 id: cord-262017-utvy0i8l author: Tobar Vega, Pool title: Talaromyces marneffei laboratory cross reactivity with Histoplasma and Blastomyces urinary antigen date: 2019-06-21 words: 1529 flesch: 33 summary: In the U.S. patients with HIV infection usually undergo testing for endemic fungal infections such as Blastomyces, Histoplasma, Coccidioides and Paracoccidioides. His past medical history was relevant for HIV infection (since age 21) on HAART (bictegravir, emtricitabine & tenofovir alafenamide). keywords: histoplasma; hiv; infection; marneffei; patients cache: cord-262017-utvy0i8l.txt plain text: cord-262017-utvy0i8l.txt item: #226 of 549 id: cord-262076-b5u5hp2r author: Liu, Ying Poi title: Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron date: 2008-03-16 words: 6911 flesch: 46 summary: We therefore selected the 19-nt inhibitors for the construction of antiviral miRNA polycistrons. HIV-1 sequences are blue, mature wild-type miRNA sequences are red, pre-miRNA sequences are black, Watson-Crick base pairs are shown with dashes and GU wobbles with dots. keywords: antiviral; cells; construct; expression; figure; hairpin; inhibition; ldr9; luciferase; mirna; shrna cache: cord-262076-b5u5hp2r.txt plain text: cord-262076-b5u5hp2r.txt item: #227 of 549 id: cord-262143-s01jrtbb author: Head, Michael G title: The allocation of US$105 billion in global funding from G20 countries for infectious disease research between 2000 and 2017: a content analysis of investments date: 2020-09-21 words: 4657 flesch: 46 summary: Global health strategy overview Sizing up pneumonia investment Global funding trends for malaria research in sub-Saharan Africa: a systematic analysis Research investments in global health: a systematic analysis of UK infectious disease research funding and global health metrics UK investments in global infectious disease research 1997-2010: a case study GBD results tool Disease control priorities: improving health and reducing poverty Ebola research funding: a systematic analysis Severe acute respiratory syndrome: historical, epidemiologic, and clinical features MERS coronavirus: diagnostics, epidemiology and transmission Monitoring investments in coronavirus research and development The missing piece. key: cord-262143-s01jrtbb authors: Head, Michael G; Brown, Rebecca J; Newell, Marie-Louise; Scott, J Anthony G; Batchelor, James; Atun, Rifat title: The allocation of US$105 billion in global funding from G20 countries for infectious disease research between 2000 and 2017: a content analysis of investments date: 2020-09-21 journal: Lancet Glob Health DOI: 10.1016/s2214-109x(20)30357-0 sha: doc_id: 262143 keywords: awards; burden; data; disease; funding; global; health; investment; research cache: cord-262143-s01jrtbb.txt plain text: cord-262143-s01jrtbb.txt item: #228 of 549 id: cord-262232-7ecg1iha author: Crakes, Katti R title: Efficacy of silk fibroin biomaterial vehicle for in vivo mucosal delivery of Griffithsin and protection against HIV and SHIV infection ex vivo date: 2020-10-18 words: 7105 flesch: 39 summary: Similar patterns in SHIV inhibition were observed in rectal explants following in vivo exposure to Grft discs ( Figure 4C ) which lasted over a 15-day time course (Figure 4D) . We report the efficacy of a silk fibroin-based platform for the rapid and sustained mucosal delivery of anti-HIV Griffithsin into the vaginal and rectal tissues in vivo and protection against SHIV and HIV ex vivo. keywords: delivery; discs; explants; figure; grft; griffithsin; hiv; infection; mucosal; placement; prevention; rectal; shiv; silk; tissue; vivo; women cache: cord-262232-7ecg1iha.txt plain text: cord-262232-7ecg1iha.txt item: #229 of 549 id: cord-262752-bwofzbwa author: Li, Qianqian title: Current status on the development of pseudoviruses for enveloped viruses date: 2017-12-07 words: 3282 flesch: 22 summary: Pseudotype formation between enveloped RNA and DNA viruses Replication and amplification of novel vesicular stomatitis virus minigenomes encoding viral structural proteins Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles Generation of VSV pseudotypes using recombinant DeltaG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines Quantification of lyssavirus-neutralizing antibodies using vesicular stomatitis virus pseudotype particles Second generation of pseudotype-based serum neutralization assay for Nipah virus antibodies: sensitive and high-throughput analysis utilizing secreted alkaline phosphatase A system for functional analysis of Ebola virus glycoprotein Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors Characterization of pseudotype VSV possessing HCV envelope proteins Use of vesicular stomatitis virus pseudotypes bearing Hantaan or Seoul virus envelope proteins in a rapid and safe neutralization test A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice Study of Andes virus entry and neutralization using a pseudovirion system Efficient production of Hantaan and Puumala pseudovirions for viral tropism and neutralization studies Analyses of entry mechanisms of novel emerging viruses using pseudotype VSV system Characterization of the interaction of Lassa fever virus with its cellular receptor alpha-dystroglycan Analysis of Lujo virus cell entry using pseudotype vesicular stomatitis virus Development of a neutralization assay for Nipah virus using pseudotype particles EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein Involvement of ceramide in the propagation of Japanese encephalitis virus Preparation of vesicular stomatitis virus pseudotype with Chikungunya virus envelope protein Efficient generation of vesicular stomatitis virus (VSV)-pseudotypes bearing morbilliviral glycoproteins and their use in quantifying virus neutralising antibodies Pseudotyping of vesicular stomatitis virus with the envelope glycoproteins of highly pathogenic avian influenza viruses A vesicular stomatitis pseudovirus expressing the surface glycoproteins of influenza A virus Analysis of the entry mechanism of Crimean-Congo hemorrhagic fever virus, using a vesicular stomatitis virus pseudotyping system Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines R-E- The VSV packaging system is a versatile tool for making pseudotyped viruses; this system is advantageous in that it has no stringent selectivity for the envelope proteins, and the resulting virus may be manipulated in a BSL-2 laboratory. keywords: envelope; neutralization; packaging; plasmid; pseudovirus; system; virus; viruses; vsv cache: cord-262752-bwofzbwa.txt plain text: cord-262752-bwofzbwa.txt item: #230 of 549 id: cord-262892-n38r8n70 author: Sheikh, Jamila title: Nutritional Care of the Child with Human Immunodeficiency Virus Infection in the United States: A Historical and Contemporary Perspective date: 2015-05-08 words: 6642 flesch: 32 summary: The global pandemic of human immunodeficiency virus (HIV) infection has had grave consequences in the lives of affected infants, children, and adolescents, with more than 33% of infant and child mortality attributed to HIV infection in endemic locations [1] . In adults, opportunistic infections (OIs) are often secondary to the reactivation of pathogens acquired before HIV infection. keywords: cart; children; disease; fat; growth; hiv; infants; infection; nutrition; states; therapy; united; virus; weight cache: cord-262892-n38r8n70.txt plain text: cord-262892-n38r8n70.txt item: #231 of 549 id: cord-263157-8jin6oru author: Martínez, Miguel Angel title: Progress in the Therapeutic Applications of siRNAs Against HIV-1 date: 2008-10-13 words: 9242 flesch: 34 summary: This review highlights the evidence showing that RNAi provides a robust method for specifically inhibiting the expression of targeted HIV-1 genes, and its promise as a novel and broadly applicable approach to antiviral therapy. Soon after the demonstration that synthetic siRNAs were able to induce the RNAi mechanism in mammalian cells (15) , several studies reported that HIV-1 gene expression and replication ex vivo could be inhibited by virus-specific synthetic siR-NAs (16 - 22) or expressed siRNAs (16, 18) that were targeted to early or late phases of virus replication. keywords: cells; expression; gene; human; infection; interference; replication; rna; rnai; sequence; shrna; silencing; sirnas; target; therapy; virus; vivo cache: cord-263157-8jin6oru.txt plain text: cord-263157-8jin6oru.txt item: #232 of 549 id: cord-263438-9ra94uda author: Snowden, Frank M. title: Emerging and reemerging diseases: a historical perspective date: 2008-09-19 words: 14396 flesch: 42 summary: key: cord-263438-9ra94uda authors: Snowden, Frank M. title: Emerging and reemerging diseases: a historical perspective date: 2008-09-19 journal: Immunol Rev DOI: 10.1111/j.1600-065x.2008.00677.x sha: doc_id: 263438 cord_uid: 9ra94uda Summary: Between mid‐century and 1992, there was a consensus that the battle against infectious diseases had been won, and the Surgeon General announced that it was time to close the book. The increasing virulence of dengue fever with dengue hemorrhagic fever and dengue shock syndrome disproved the theory of the evolution toward commensalism, and the discovery of the microbial origins of peptic ulcer demonstrated the reach of infectious diseases. keywords: aids; care; century; dengue; diseases; epidemic; global; health; human; infections; major; malaria; national; new; people; poverty; public; response; sars; states; surveillance; threat; time; united; world cache: cord-263438-9ra94uda.txt plain text: cord-263438-9ra94uda.txt item: #233 of 549 id: cord-263452-y2ral8nx author: Watanabe, Yasunori title: Site-specific glycan analysis of the SARS-CoV-2 spike date: 2020-05-04 words: 2075 flesch: 39 summary: Note that the flexible loops on which N74 and N149 glycan sites reside are represented as dashed lines with glycan sites on the loops mapped at their approximate regions. In HIV-1 immunogen research, the holes generated by unoccupied glycan sites have been shown to be immunogenic and potentially give rise to distracting epitopes (26) . keywords: cov-2; glycan; protein; sars; sites; spike cache: cord-263452-y2ral8nx.txt plain text: cord-263452-y2ral8nx.txt item: #234 of 549 id: cord-263645-wupre5uj author: Morgan, Brittany S title: Insights into the development of chemical probes for RNA date: 2018-09-19 words: 7113 flesch: 31 summary: We discuss the applicability of current tools to identify and evaluate RNA-targeted chemical probes, suggest criteria to assess the quality of RNA chemical probes and targets, and propose areas where new tools are particularly needed. A virus RNA promoter for up-regulating the translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by binding to the G-quadruplex-forming sequence in the 5 untranslated region (UTR) of its mRNA Studying a drug-like, RNA-focused small molecule library identifies compounds that inhibit RNA toxicity in Myotonic Dystrophy Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts Structure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 Rev protein function Targeting RNA-protein interactions within the Human Immunodeficiency Virus Type 1 lifecycle A small molecule that represses translation of G-quadruplex-containing mRNA Thermodynamic studies of a series of homologous HIV-1 TAR RNA ligands reveal that loose binders are stronger Tat competitors than tight ones Development of small molecules with a noncanonical binding mode to HIV-1 Trans Activation Response (TAR) RNA keywords: binding; cell; chemical; discovery; library; ligands; molecules; probes; protein; rna; rnas; screening; structure; target; targeting cache: cord-263645-wupre5uj.txt plain text: cord-263645-wupre5uj.txt item: #235 of 549 id: cord-263965-i8yutik6 author: Relf, Michael V. title: What's Old is New! Similarities Between SARS-CoV-2 and HIV date: 2020-04-09 words: 1789 flesch: 57 summary: However, despite guidelines from CDC in 2006 that recommended HIV testing for everyone between the ages of 13 and 64 years as part of routine health care, we do not see people asking to be tested for HIV. Similarly, HIV providers, including nurses and nurse practitioners from around the world, are wondering what to advise persons living with HIV about this contemporary threat. keywords: disease; hiv; sars; world cache: cord-263965-i8yutik6.txt plain text: cord-263965-i8yutik6.txt item: #236 of 549 id: cord-264050-6zpw6itb author: Pirofski, Liise-anne title: Immune-Mediated Damage Completes the Parabola: Cryptococcus neoformans Pathogenesis Can Reflect the Outcome of a Weak or Strong Immune Response date: 2017-12-12 words: 2755 flesch: 27 summary: This has led to the prevailing view that this disease is the result of weak immune responses that cannot control the fungus. C. neoformans was first classified as a class 2 pathogen, the definition of which was pathogens that cause damage either in hosts with weak immune responses or in the setting of normal immune responses (3). keywords: damage; hiv; host; immune; response cache: cord-264050-6zpw6itb.txt plain text: cord-264050-6zpw6itb.txt item: #237 of 549 id: cord-264159-e9071tyv author: Lin, Weikang Nicholas title: The Role of Single-Cell Technology in the Study and Control of Infectious Diseases date: 2020-06-10 words: 13350 flesch: 31 summary: COVID-19 Coronavirus Pandemic Trade Set to Plunge as COVID-19 Pandemic Upends Global Economy Microbiology by numbers History of the discovery of the malaria parasites and their vectors The use of single-cell RNA-Seq to understand virus-host interactions Breaking the population barrier by single cell analysis: One host against one pathogen Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection Extreme heterogeneity of influenza virus infection in single cells High-Throughput Single-Cell Kinetics of Virus Infections in the Presence of Defective Interfering Particles Single-Cell Virus Sequencing of Influenza Infections That Trigger Innate Immunity Single-Cell Analysis of RNA Virus Infection Identifies Multiple Genetically Diverse Viral Genomes within Single Infectious Units Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses Phenotypic variation of Salmonella in host tissues delays eradication by antimicrobial chemotherapy Single-Cell Analysis of the Impact of Host Cell Heterogeneity on Infection with Foot-and-Mouth Disease Virus Nile Virus-Inclusive Single-Cell RNA Sequencing Reveals Heterogeneity in the Type One area of virology that has benefited from the enhanced resolution of single-cell technologies is the study of variation in infection across single cells and the reasons for such variation. keywords: analysis; antibodies; antibody; antigen; cell; cytometry; data; disease; expression; flow; heterogeneity; host; human; infection; pathogen; responses; rna; scrna; seq; sequencing; studies; study; technologies; throughput; vaccine; virus cache: cord-264159-e9071tyv.txt plain text: cord-264159-e9071tyv.txt item: #238 of 549 id: cord-264225-vzcfeh7t author: Talbert-Slagle, Kristina title: Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body date: 2014-05-08 words: 5184 flesch: 30 summary: Resting human CD4+ T cells in the human genital mucosa are therefore even less likely to be able to produce and spread HIV than are resting CD4+ T cells in a nonhuman primate model. +/CD4+ T cells as key targets in mucosal transmission HIV-1 envelope replication and alpha4beta7 utilization among newly infected subjects and their corresponding heterosexual partners Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of alpha4beta7 integrin Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin alpha4beta7 Application of a case-control study design to investigate genotypic signatures of HIV-1 transmission Evaluation of cervical mucosa in transmission bottleneck during acute HIV-1 infection using a cervical tissue-based organ culture Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocytederived macrophages Stochastic theory of early viral infection: continuous versus burst production of virions Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection Early events in sexual transmission of HIV and SIV and opportunities for interventions Circulating CD4(+) and CD8(+) T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation The basic reproductive number of Ebola and the effects of public health measures: the cases of Congo and Uganda The reemergence of Ebola hemorrhagic fever, Democratic Republic of the Congo An epidemic of measles in southern Greenland, 1951; measles in virgin soil. keywords: cd4; cells; expression; heterogeneity; hiv; individual; infected; infection; transmission; virus cache: cord-264225-vzcfeh7t.txt plain text: cord-264225-vzcfeh7t.txt item: #239 of 549 id: cord-264408-vk4lt83x author: Ruiz, Sara I. title: Animal Models of Human Viral Diseases date: 2017-06-23 words: 34509 flesch: 38 summary: The severe acute respiratory syndrome severe acute respiratory syndrome Bacterial sinusitis and otitis media following influenza virus infection in ferrets Neuropathology of H5N1 virus infection in ferrets The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease Immunopathogenesis of coronavirus infections: implications for sArs Hantavirus pulmonary syndrome: the new American hemorrhagic fever rift Valley fever Inbred rat strains mimic the disparate human response to rift Valley fever virus infection experimental studies of arenaviral hemorrhagic fevers experimental rift Valley fever in rhesus macaques Bovine respiratory syncytial virus protects cotton rats against human respiratory syncytial virus infection Human Hendra virus encephalitis associated with equine outbreak Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virus structure as revealed by airway dissection. emerg Generation of a transgenic mouse model of Middle east respiratory syndrome coronavirus infection and disease Pathological changes in brain and other target organs of infant and weanling mice after infection with nonneuroadapted Western equine encephalitis virus Particle-to-PFU ratio of ebola virus influences disease course and survival in cynomolgus macaques Progress toward norovirus vaccines: considerations for further development and implementation in potential target populations Characterization of lethal Zika virus infection in AG129 mice experimental in vitro and in vivo models for the study of human hepatitis B virus infection A model of meningococcal bacteremia after respiratory superinfection in influenza A virus-infected mice Middle east respiratory syndrome coronavirus: current situation and travel-associated concerns Aerosol exposure to the Angola strain of marburg virus causes lethal viral hemorrhagic fever in cynomolgus macaques Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola Virus-Infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death American Academy of Pediatrics subcommittee on Diagnosis and Management of Bronchiolitis Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models The gerbil, Meriones unguiculatus, a model for rift Valley fever viral encephalitis Morbidity and mortality among patients with respiratory syncytial virus infection: a 2-year retrospective review Chikungunya and the nervous system: what we do and do not know The West Nile virus outbreak of 1999 in New York: the Flushing Hospital experience Hospital outbreak of Middle east respiratory syndrome coronavirus Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses Norovirus vaccine against experimental human Norwalk Virus illness Determination of the 50% human infectious dose for Norwalk virus An epizootic attributable to Western equine encephalitis virus infection in emus in Texas evidence for camel-to-human transmission of Mers coronavirus Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted rag2 −/− gamma c keywords: acute; aerosol; animal; animal model; cells; challenge; clinical; coronavirus; cov; cynomolgus; days; dengue; disease; encephalitis; et al; experimental; exposure; ferrets; fever; fever virus; guinea; hepatitis; human; infected; infection; infection model; influenza; influenza virus; inoculation; lethal; liver; macaques; mice; model; monkeys; mouse; mouse model; nhps; pathogenesis; pigs; replication; response; rhesus; route; sars; signs; strain; studies; study; symptoms; syndrome; transmission; vaccine; viral; viremia; virus; virus infection; viruses cache: cord-264408-vk4lt83x.txt plain text: cord-264408-vk4lt83x.txt item: #240 of 549 id: cord-264699-l8db5gll author: Kino, Tomoshige title: Virus-mediated modulation of the host endocrine signaling systems: clinical implications date: 2007-06-30 words: 4737 flesch: 28 summary: By contrast, ACE2 [53] converts ANG I and ANG II into angiotensin (1-9) and angiotensin (1-7), respectively lymphoma independent of human T-cell lymphotropic virus type-1 tax expression Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy Metabolic complications associated with antiretroviral therapy Metabolic disorders among HIV-infected patients treated with protease inhibitors: a review HIV-associated lipodystrophy syndrome Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? Endocrine and metabolic evaluation of human immunodeficiency virus-infected patients with evidence of protease inhibitor-associated lipodystrophy AIDS-related Kaposi's sarcoma: evidence for direct stimulatory effect of glucocorticoid on cell proliferation Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1 Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection CBP/ A different view of smallpox and vaccination HIV/AIDS epidemiology, pathogenesis, prevention, and treatment ACE2: from vasopeptidase to SARS virus receptor Immunology of viral infections Molecular mimicry and immune-mediated diseases The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation Effectiveness of prolonged glucocorticoid treatment in acute respiratory distress syndrome: the right drug, the right way? Immune modulation of the hypothalamicpituitary-adrenal (HPA) axis during viral infection Adenovirus E1A: remodelling the host cell, a life or death experience AIDS-related lipodystrophy/insulin resistance syndrome Hypercalcemia, parathyroid hormone-related protein expression and human T-cell leukemia virus infection HIV gp120 inhibits the somatotropic axis: a possible GH-releasing hormone receptor mechanism for the pathogenesis of AIDS wasting Perturbation of in vitro HIV pathogenic effects by peptides showing sequence similarities with the C2 conserved domain of gp120 Vasoactive intestinal peptide 1-12: a ligand for the CD4 (T4)/human immunodeficiency virus receptor Nucleotide and amino acid homology between the human thyrotropin receptor and the HIV-1 Nef protein: identification and functional analysis Glucocorticoid and mineralocorticoid resistance/hypersensitivity syndromes Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be transactivated by HTLV-1 tax gene Parathyroid hormone and parathyroid hormone-related peptide, and their receptors Molecular mechanisms of cellular transformation by HTLV-1 Tax Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter Humoral hypercalcemia of malignancy: severe combined immunodeficient/beige mouse model of adult T-cell ACE converts angiotensin I (ANG I) into ANG II, which acts as a vasopressor and a mitogen for smooth muscle cells and fibroblasts through the angiotensin 1 (AT1) receptor. keywords: cell; endocrine; host; human; insulin; molecules; protein; syndrome; virus; viruses; vpr cache: cord-264699-l8db5gll.txt plain text: cord-264699-l8db5gll.txt item: #241 of 549 id: cord-264713-38dlh3wg author: Vernet, Guy title: Molecular diagnostics in virology date: 2004-08-20 words: 4802 flesch: 36 summary: in 2001 illustrate the interest of multiplex detection of respiratory viruses by NAT. Table 6 Multiplex Nat for the detection of respiratory viruses (Hexaplex, Prodesse Inc.) DNA-microarrays or DNA-Chips are very powerful detection tools that can be combined with amplification techniques to detect viruses or virus variants (reviewed in Clewley, 2004) . keywords: amplification; assays; blood; detection; dna; hbv; hcv; hiv; nat; pcr; time; viruses cache: cord-264713-38dlh3wg.txt plain text: cord-264713-38dlh3wg.txt item: #242 of 549 id: cord-264884-ydkigome author: Villarreal, Luis P. title: The Widespread Evolutionary Significance of Viruses date: 2008-07-05 words: 23160 flesch: 41 summary: key: cord-264884-ydkigome authors: Villarreal, Luis P. title: The Widespread Evolutionary Significance of Viruses date: 2008-07-05 journal: Origin and Evolution of Viruses DOI: 10.1016/b978-0-12-374153-0.00021-7 sha: doc_id: 264884 cord_uid: ydkigome In the last 30 years, the study of virus evolution has undergone a transformation. Originally concerned with disease and its emergence, virus evolution had not been well integrated into the general study of evolution. keywords: complex; disease; diversity; dna; dna viruses; et al; eukaryotic; evolution; example; genes; genomes; host; host evolution; human; infection; infl; life; like; mhv; mouse; origin; persistence; phage; populations; quasispecies; recombination; replication; rna; role; specifi; tness; type; uenza; viral; virus; virus evolution; viruses cache: cord-264884-ydkigome.txt plain text: cord-264884-ydkigome.txt item: #243 of 549 id: cord-264986-glm2qcuz author: Tam, Cheuk Chi title: Psychological Distress Among HIV Healthcare Providers During the COVID-19 Pandemic in China: Mediating Roles of Institutional Support and Resilience date: 2020-10-21 words: 4831 flesch: 31 summary: However, limited COVID-19 research examined the mechanisms of psychological distress among HIV healthcare providers. Psychological distress among HIV healthcare providers in China could be particularly concerning due to several COVID-19 related stressors at HIV clinics. keywords: covid-19; distress; healthcare; hiv; pandemic; providers; resilience; stressors; support cache: cord-264986-glm2qcuz.txt plain text: cord-264986-glm2qcuz.txt item: #244 of 549 id: cord-264994-j8iawzp8 author: Fitzpatrick, Meagan C. title: Modelling microbial infection to address global health challenges date: 2019-09-20 words: 7107 flesch: 26 summary: Projections of Ebola outbreak size and duration with and without vaccine use in Équateur Ebola vaccination in the Democratic Republic of the Congo Emergence and pandemic potential of swine-origin H1N1 influenza virus Estimated influenza illnesses, medical visits, hospitalizations, and deaths averted by vaccination in the United States Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997-2015: a systematic review of individual case data The role of evolution in the emergence of infectious diseases Information technology and global surveillance of cases of 2009 H1N1 influenza Optimizing provider recruitment for influenza surveillance networks Influenza A (H7N9) and the importance of digital epidemiology Disease surveillance on complex social networks Optimizing infectious disease interventions during an emerging epidemic Optimizing influenza vaccine distribution Nine challenges in incorporating the dynamics of behaviour in infectious diseases models Evolutionary game theory and social learning can determine how vaccine scares unfold Department of Health & Human Services. By explicitly defining the nonlinear processes underlying infectious disease spread, transmission models illuminate these otherwise opaque systems. keywords: analysis; data; disease; dynamics; ebola; example; health; hiv; modelling; models; outbreak; population; resistance; risk; transmission; vaccination; vaccine cache: cord-264994-j8iawzp8.txt plain text: cord-264994-j8iawzp8.txt item: #245 of 549 id: cord-265146-j0n3a4m6 author: Hsieh, Ying-Hen title: Ascertaining the 2004–2006 HIV type 1 CRF07_BC outbreak among injecting drug users in Taiwan date: 2013-02-12 words: 4158 flesch: 53 summary: Correlation results also suggest that the upsurge in male HIV cases led to the subsequent drastic surge in female cases. Correlation results also suggest that the upsurge in male HIV cases led to the subsequent drastic surge in female cases. keywords: cases; female; hiv; idus; series; taiwan; time cache: cord-265146-j0n3a4m6.txt plain text: cord-265146-j0n3a4m6.txt item: #246 of 549 id: cord-265600-lnik974k author: Celerino da Silva, Ronaldo title: Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission date: 2011-01-26 words: 5519 flesch: 46 summary: The signs for infection C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans CD209L) and DCSIGN(CD209) mediate transinfection of liver cells by hepatitis C virus Hepatitis C virus glycoproteins interact with DC-SIGN and DCSIGNR CD209) mediates dengue virus infection of human dendritic cells Human cytomegalovirus binding to DC-SIGN is required for dendritic cell infection and target cell trans-infection DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus PH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DCSIGN Role of the C-type lectins DC-SIGN and L-SIGN in Leishmania interaction with host phagocytes DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein CD209L LSIGNS) is a receptor for severeacute respiratory syndrome coronavirus Identification of the mycobacterial carbohydratestructure that binds the Ctype lectins DC-SIGN, L-SIGN and SIGNR1 Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR DC-SIGN, a dendritic cell-specific HIV-binding protein that enhances trans-infection of T cells Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin DCSIGNS)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV infection Dendritic-cell interactions with HIV: Infection and viral dissemination Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor Influence of polymorphism in dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related. However, Raji cells expressing DC-SIGN, incubated with HIV-1 virus and uninfected human milk, showed a significant reduction of the binding of HIV-1 gp120 to DC-SIGN receptor. keywords: binding; cells; human; infection; milk; receptors; sign; transmission; virus cache: cord-265600-lnik974k.txt plain text: cord-265600-lnik974k.txt item: #247 of 549 id: cord-265699-0socw0hp author: Ortega, Miguel Ángel title: Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases date: 2020-09-14 words: 11158 flesch: 36 summary: An assessment of the merits of covalent conjugation compared to noncovalent encapsulation Dendrimers for gene delivery-a potential approach for ocular therapy? PEGylated PAMAM dendrimers as a potential drug delivery carrier: in vitro and in vivo comparative evaluation of covalently conjugated drug and noncovalent drug inclusion complex Function oriented molecular design: Dendrimers as novel antimicrobials Dendrimers and dendritic polymers as anti-infective agents: New antimicrobial strategies for therapeutic drugs Dendrimers-revolutionary drugs for infectious diseases Application of dendrimers for the treatment of infectious diseases In Dendrimer Chemistry: Synthetic Approaches towards Complex Architectures Bench-to-bedside translation of dendrimers: Reality or utopia? PLL differ from other dendrimers such as PAMAM and PPI in the asymmetry of their branching cell, which inevitably influences the encapsulation properties as they possess no interior void space [37] . keywords: activity; agents; approach; bacteria; carbosilane; cells; delivery; dendrimers; development; diagnosis; diseases; drug; figure; groups; hiv; infections; pamam; peptide; prevention; prion; resistance; treatment; use cache: cord-265699-0socw0hp.txt plain text: cord-265699-0socw0hp.txt item: #248 of 549 id: cord-266226-gxbrgy6g author: Lee, Choongho title: Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application date: 2019-10-06 words: 7034 flesch: 48 summary: Conversely, introducing glycosylation sites at N234 and N295 in HIV-1 clade C virus increased GRFT antiviral potency [25] . Since the antiviral activity of GRFT mainly depends on disrupting the biological functions of multiple mannose molecules on viral glycoproteins, a reduction in the glycosylation levels of a target protein can lead to GRFT resistance. keywords: activity; anti; binding; carbohydrate; cell; gp120; grft; griffithsin; hiv; mannose; protein; sign; sites; virus cache: cord-266226-gxbrgy6g.txt plain text: cord-266226-gxbrgy6g.txt item: #249 of 549 id: cord-266294-ua22udlc author: Koch, Oliver title: 29 Antiviral drugs date: 2010-12-31 words: 10818 flesch: 39 summary: Metabolism The hemochromatosis gene polymorphism HFE 187C> G and possibly mitochondrial haplogroup J gave relative protection against lipoatrophy during antiretroviral drug therapy in a trial in which 96 patients were randomized to didanosine þ stavudine or zidovudine þ lamivudine, combined with efavirenz and/ or nelfinavir in AIDS Clinical Trials Group (ACTG) 384 sub-study A5005s (20 C ). The use of isoniazid preven tive therapy during antiretroviral drug therapy did not increase the risk of hepatotoxicity. keywords: abacavir; combination; dose; drug; efavirenz; hepatitis; hiv; lamivudine; nevirapine; patients; ribavirin; ritonavir; stavudine; study; tenofovir; therapy; tipranavir; treatment; women; zidovudine cache: cord-266294-ua22udlc.txt plain text: cord-266294-ua22udlc.txt item: #250 of 549 id: cord-267182-ctvnmjsl author: Mboowa, Gerald title: Human Genomic Loci Important in Common Infectious Diseases: Role of High-Throughput Sequencing and Genome-Wide Association Studies date: 2018-03-20 words: 4743 flesch: 21 summary: Furthermore, HTS has given us unprecedented resolution of understanding the role of host genetics to infectious diseases susceptibility. Review of findings to date suggests that the genetic architecture of infectious disease susceptibility may be importantly different from that of noninfectious diseases [20] . keywords: association; disease; genome; hiv; host; hts; malaria; resistance; selection; sequencing; susceptibility; tuberculosis cache: cord-267182-ctvnmjsl.txt plain text: cord-267182-ctvnmjsl.txt item: #251 of 549 id: cord-268712-rxdw553c author: Sawyer, Alexandra title: Posttraumatic growth and adjustment among individuals with cancer or HIV/AIDS: A meta-analysis date: 2010-03-02 words: 8823 flesch: 36 summary: Categories of positive psychological adjustment did not significantly moderate the relationship between PTG and positive mental health (p N .05). Time emerged as a significant moderator of positive psychological adjustment (β = .005, p b .001), implying the longer the time since the event, the stronger the relationship between PTG and positive mental health. keywords: adjustment; aids; analysis; cancer; effect; growth; health; hiv; life; ptg; relationship; studies cache: cord-268712-rxdw553c.txt plain text: cord-268712-rxdw553c.txt item: #252 of 549 id: cord-268776-yfq9oky5 author: Mattson, Mark P. title: Infectious agents and age-related neurodegenerative disorders date: 2003-11-05 words: 6042 flesch: 23 summary: A␤ may damage neurons and render them vulnerable to excitotoxicity and apoptosis by inducing membrane lipid peroxidation and impairing the function of ion-motive ATPases, glucose and gluatmate transporters, and ion channels (Mattson et al., 1992; Mark et al., 1997; Guo et al., 1998 Guo et al., , 1999a (Fig. 3) . In addition to the cascades that result in the death of neurons, several important neuroprotective signaling pathways are activated after a stroke including intercellular signaling involving neurotrophic factors and cytokines, and intracellular pathways involving calcium and transcription factors such as NF-B and CREB (Mattson, 1997b; Mattson et al., 2000; . keywords: als; brain; cells; dementia; disease; et al; infection; neurons; patients; stroke; virus cache: cord-268776-yfq9oky5.txt plain text: cord-268776-yfq9oky5.txt item: #253 of 549 id: cord-268901-7cm6m1ol author: Ku, Therese title: Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1 date: 2019-07-01 words: 7823 flesch: 59 summary: Design, synthesis, and preliminary biological activity Reverse carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors Structure-based identification of HIV-1 nucleocapsid protein inhibitors active against wild-type and drug-resistant HIV-1 strains Use of virtual screening for discovering antiretroviral compounds interacting with the HIV-1 nucleocapsid protein Molecular dynamics and DFT study on HIV-1 nucleocapsid protein-7 in complex with viral genome Predicting the binding mode of known NCp7 inhibitors to facilitate the design of novel modulators DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection HIV-1 nucleocapsid protein zinc finger structures induce tRNA(Lys,3) structural changes but are not critical for primer/template annealing Genomic placement and the initiation step of reverse transcription in human immunodeficiency virus type 1 Nucleocapsid protein function in early infection processes Analysis of NCp7-dependent activation of HIV-1 cDNA integration and its conservation among retroviral nucleocapsid proteins Structure of the HIV-1 nucleocapsid protein bound to the SL3 psi-RNA recognition element Affinities of packaging domain loops in HIV-1 RNA for the nucleocapsid protein Effects of the nature and concentration of salt on the interaction of the HIV-1 nucleocapsid protein with SL3 RNA Flexible nature and specific functions of the HIV-1 nucleocapsid protein Retroviral RNA dimerization and packaging: the what, how, when, where, and why Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus Identification of HIV-1 inhibitors targeting the nucleocapsid protein Targeting the viral nucleocapsid protein in anti-HIV-1 therapy Nucleocapsid protein: a desirable target for future therapies against HIV-1 The nucleocapsid protein of HIV-1 as a promising therapeutic target for antiviral drugs Synthesis and evaluation of bifunctional aminothiazoles as antiretrovirals targeting the HIV-1 nucleocapsid protein Time-resolved fluorescence investigation of the human immunodeficiency virus type 1 nucleocapsid protein: influence of the binding of nucleic acids Probing the HIV-1 NCp7 nucleocapsid protein with site-specific gold(I)-phosphine complexes Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC) Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein FRED pose prediction and virtual screening accuracy FRED 3.0.1 OpenEye Scientific Software Suppression of a palladium-mediated homocoupling in a Suzuki cross-coupling reaction. DNA from transformants were sequenced and found to be identical with the HIV-1 NC coding sequence in pNL4-3. keywords: crude; dropwise; material; mmol; protein; yield cache: cord-268901-7cm6m1ol.txt plain text: cord-268901-7cm6m1ol.txt item: #254 of 549 id: cord-268977-hcg2rrhl author: Feikin, Daniel R. title: Etiology and Incidence of Viral and Bacterial Acute Respiratory Illness among Older Children and Adults in Rural Western Kenya, 2007–2010 date: 2012-08-24 words: 6449 flesch: 43 summary: The percentage of malaria blood smears positive among ARI patients ranged from (13) 1041 (10) 341 (8) 3406 (11) -1194 (62) 2212 (8) 489 (14) 802 (7) CFR a for ARI cases (5) 15 (4) 73 (2) -69 For ARI patients, blood, nasopharyngeal and oropharyngeal specimens using polyester-tipped swabs, and urine were collected. keywords: adults; ari; cases; controls; hiv; incidence; influenza; pathogen; patients; pneumonia; study; virus; years cache: cord-268977-hcg2rrhl.txt plain text: cord-268977-hcg2rrhl.txt item: #255 of 549 id: cord-269194-b1wlr3t7 author: Engstrom-Melnyk, Julia title: Chapter 5 Clinical Applications of Quantitative Real-Time PCR in Virology date: 2015-12-31 words: 12555 flesch: 22 summary: Determining a patient's HIV viral load is indicated prior to entry into care, at the initiation of ART, at 2-8 weeks after ART initiation, and then typically every 3-4 months while on treatment: (1) to establish a baseline level of HIV viral load; (2) to establish viral response to the therapy to assess the virologic efficacy of ART; and (3) to monitor for abnormalities that may be associated with antiretroviral drugs (DHHS HIV, 2014) . (A) HIV viral loads will fluctuate as patients are on treatment, and, in most instances, will remain 'undetectable' (at or below dotted line); viral 'blips' are not uncommon and will result in transient 'detectable' and even quantifiable results (above the dashed line). keywords: assays; chronic; clinical; cmv; disease; et al; fda; hcv; hiv; infection; laboratory; load; molecular; patients; pcr; results; rna; testing; tests; therapy; time; time pcr; transplant; treatment; virus cache: cord-269194-b1wlr3t7.txt plain text: cord-269194-b1wlr3t7.txt item: #256 of 549 id: cord-269222-g2ibmo75 author: Valenti, Piera title: Role of Lactobacilli and Lactoferrin in the Mucosal Cervicovaginal Defense date: 2018-03-01 words: 9646 flesch: 19 summary: Lactobacilli exert their protective effects by several mechanisms: (i) microbial competition for the nutrients and for adherence to the vaginal epithelium; (ii) reduction of the vaginal pH by the production of organic acids, especially lactic acid, through the degradation of glycogen released by vaginal cells thus exerting selective antimicrobial activity against non-resident microbiota; (iii) production of antimicrobial substances, such as bacteriocins and hydrogen peroxide (H2O2) able to suppress the growth of several microorganisms; and (iv) modulation of the local immune system (16) . Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis Vaginal microbiota of adolescent girls prior to the onset of menarche resemble those of reproductive-age women A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy Pregnancy's stronghold on the vaginal microbiome Vaginal microbiome and epithelial gene array in post-menopausal women with moderate to severe dryness Prevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: implications for HIV transmission Changes in vaginal community state types reflect major shifts in the microbiome Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study Hormonal contraceptive use modulates the local inflammatory response to bacterial vaginosis Injectable progestin-only contraception is associated with increased levels of proinflammatory cytokines in the female genital tract Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling Cervical inflammation and immunity associated with hormonal contraception, pregnancy, and HIV-1 seroconversion Estrogen regulation of lactoferrin expression in human endometrium Lactoferrin gene expression and regulation: an overview Lactoferrin: the path from protein to gene Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens Differential expression and estrogen response of lactoferrin gene in the female reproductive tract of mouse, rat, and hamster Chlamydia trachomatis infection in the female reproductive tract of the rat: influence of progesterone on infectivity and immune response Antigen-presenting cells in the female reproductive tract: influence of estradiol on antigen presentation by vaginal cells The complex role of estrogens in inflammation Immunoendocrine mechanisms associated with resistance or susceptibility to parasitic diseases during pregnancy A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle Bone health in menopausal women: a role for general practitioners. keywords: blf; cells; hlf; host; human; immune; infection; iron; lactobacilli; lactoferrin; levels; microbial; mucosal; trachomatis; tract; vaginosis; women cache: cord-269222-g2ibmo75.txt plain text: cord-269222-g2ibmo75.txt item: #257 of 549 id: cord-269759-1n1oo6wc author: Villamil-Gómez, Wilmer E. title: Fatal human coronavirus 229E (HCoV-229E) and RSV–Related pneumonia in an AIDS patient from Colombia date: 2020-02-06 words: 838 flesch: 40 summary: We would like to discuss the relevance of other respiratory viruses, including other CoV different to MERS-CoV, the Severe Acute Respiratory Syndrome CoV (SARS-CoV) and the 2019 novel CoV (2019nCoV) key: cord-269759-1n1oo6wc authors: Villamil-Gómez, Wilmer E.; Sánchez, Álvaro; Gelis, Libardo; Silvera, Luz Alba; Barbosa, Juliana; Otero-Nader, Octavio; Bonilla-Salgado, Carlos David; Rodríguez-Morales, Alfonso J. title: Fatal human coronavirus 229E (HCoV-229E) and RSV–Related pneumonia in an AIDS patient from Colombia date: 2020-02-06 journal: Travel Med Infect Dis DOI: 10.1016/j.tmaid.2020.101573 sha: doc_id: 269759 cord_uid: 1n1oo6wc nan We have read the article of Yavarian et al. keywords: coronavirus; cov; mers; patient cache: cord-269759-1n1oo6wc.txt plain text: cord-269759-1n1oo6wc.txt item: #258 of 549 id: cord-269862-krcu3hfa author: Wang, Shui-Mei title: APOBEC3G cytidine deaminase association with coronavirus nucleocapsid protein date: 2009-05-25 words: 6903 flesch: 44 summary: Like HIV-1 NC, the SARS-CoV or HCoV-229E N-associated with hA3G depends on the presence of RNA, with the first linker region essential for hA3G packaging into both HIV-1 and SARS-CoV VLPs. However, replacing NC with a leucine-zipper motif that does not encapsidate RNA abolishes hA3G packaging without significantly affecting HIV-1 virion production (Zennou et al., 2004) , suggesting RNA involvement in hA3G incorporation. keywords: cov; et al; gst; ha3; human; packaging; rna; sars; vlps cache: cord-269862-krcu3hfa.txt plain text: cord-269862-krcu3hfa.txt item: #259 of 549 id: cord-270399-yfko8mpc author: Foster, Allison title: It’s complicated: A case report on a COVID-19-positive HIV patient presenting with rhabdomyolysis and acute kidney injury date: 2020-10-15 words: 3402 flesch: 42 summary: Recent studies have demonstrated that approximately 20%-40% of COVID-19 patients admitted to the intensive care unit (ICU) develop acute kidney injury (AKI). In a recent histopathologic examination of COVID-19 patients, 9 SARS-CoV-2-associated pulmonary lesions manifest as inflammation of the parenchyma and interstitium, with hyperplasia of the alveolar epithelium and formation of hyaline membranes. keywords: aki; cov-2; covid-19; hiv; injury; kidney; patient; sars cache: cord-270399-yfko8mpc.txt plain text: cord-270399-yfko8mpc.txt item: #260 of 549 id: cord-270726-w59fu9c9 author: Dikman, Andrew E. title: Human Immunodeficiency Virus-Associated Diarrhea: Still an Issue in the Era of Antiretroviral Therapy date: 2015-03-14 words: 5195 flesch: 40 summary: The etiology of noninfectious diarrhea in patients with HIV is multifactorial and includes ART-associated diarrhea and gastrointestinal damage related to HIV infection (i.e., HIV enteropathy). The GI tract is targeted during all phases of HIV infection, but the effects of HIV on the mucosal immune system are most apparent in the acute infection period. keywords: aids; art; cd4; cells; diagnosis; diarrhea; hiv; infection; mucosal; patients; therapy cache: cord-270726-w59fu9c9.txt plain text: cord-270726-w59fu9c9.txt item: #261 of 549 id: cord-270868-4s3q2i6v author: Collins, Lauren F. title: Clinical characteristics, comorbidities and outcomes among persons with HIV hospitalized with coronavirus disease 2019 in Atlanta, Georgia date: 2020-10-01 words: 2185 flesch: 42 summary: This report supports dedicated larger study of COVID-19 among PWH to determine the role of age, comorbidities, immunocompetency, HIV control and antiretroviral agents in mediating COVID-19 presentation and its sequelae. COVID-19): people who are at higher risk Challenges of reaching 90-90-90 in the Southern United States Comorbidities in persons with HIV: the lingering challenge The prevalence and burden of non-AIDS comorbidities among women living with or at-risk for HIV infection in the United States Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Characteristics of hospitalized adults with COVID-19 in an integrated healthcare system in California COVID-19 in HIV Investigators. It is possible that the premature onset of multimorbidity among PWH considerably impacts SARS-CoV-2 infection and illness severity, distinct from HIV infection or its associated immunosuppression. keywords: comorbidities; covid-19; hiv; patients; pwh cache: cord-270868-4s3q2i6v.txt plain text: cord-270868-4s3q2i6v.txt item: #262 of 549 id: cord-271188-ewlxy5po author: Liu, Wei title: Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival date: 2020-04-20 words: 4264 flesch: 35 summary: Thus, limiting iron represents a promising adjuvant strategy in treating viral infection through oral uptake or venous injection of iron chelators, or through the manipulation of the key iron regulators. The first strategy is to deplete iron directly by iron chelators which have strong and selective affinity with iron ions [47, 48] . keywords: cells; chelators; coronavirus; cov; cov-2; covs; human; infection; iron; protein; replication; rna; sars cache: cord-271188-ewlxy5po.txt plain text: cord-271188-ewlxy5po.txt item: #263 of 549 id: cord-271241-w1q46y63 author: Ruggiero, Emanuela title: Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy date: 2020-05-18 words: 8942 flesch: 39 summary: In this chapter, we present the state of the art on the structural and functional characterization of viral G4s in RNA viruses, DNA viruses and retroviruses. 51 HCV was also used as the reference RNA virus to develop a fluorescence light-up probe, a thioflavine T derivative (ThT-NE), for the direct visualization of the native HCV RNA genome in living cells. keywords: activity; antiviral; cells; dna; ebna1; g4s; genome; hcv; host; human; ligands; ltr; quadruplex; replication; rna; viral; virus; viruses cache: cord-271241-w1q46y63.txt plain text: cord-271241-w1q46y63.txt item: #264 of 549 id: cord-271948-iq29xqrn author: Obeng, Billal Musah title: Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana date: 2020-07-24 words: 3583 flesch: 51 summary: Sequences were submitted to the Stanford University HIV Drug Resistance Database (https:// hivdb.stanford.edu/hivdb/by-sequences/) to assign subtypes detect HIV drug resistance mutations and. key: cord-271948-iq29xqrn authors: Obeng, Billal Musah; Bonney, Evelyn Yayra; Asamoah-Akuoko, Lucy; Nii-Trebi, Nicholas Israel; Mawuli, Gifty; Abana, Christopher Zaab-Yen; Sagoe, Kwamena William Coleman title: Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana date: 2020-07-24 journal: Virol J DOI: 10.1186/s12985-020-01386-y sha: doc_id: 271948 cord_uid: iq29xqrn BACKGROUND: Detection of HIV-1 transmitted drug resistance (TDR) and subtype diversity (SD) are public health strategies to assess current HIV-1 regimen and ensure effective therapeutic outcomes of antiretroviral therapy (ART) among HIV-1 patients. keywords: blood; drug; ghana; hiv; resistance; samples; study; subtype cache: cord-271948-iq29xqrn.txt plain text: cord-271948-iq29xqrn.txt item: #265 of 549 id: cord-271970-i35pic5o author: Boris, Bonaventure title: A genome-wide CRISPR/Cas9 knock-out screen identifies the DEAD box RNA helicase DDX42 as a broad antiviral inhibitor date: 2020-10-28 words: 6369 flesch: 39 summary: With the aim of identifying new cellular inhibitors of HIV-1, we have developed a strategy in which we took advantage of the ability of type 1 interferon (IFN) to potently inhibit HIV-1 infection, in order to create a cellular environment hostile to viral replication. Similarly, the overexpression of a dominant-negative mutant of DDX42 positively impacted HIV-1 infection, whereas wild-type DDX42 overexpression potently inhibited HIV-1 infection. keywords: cas9; cd4; cells; ddx42; et al; figure; genome; human; ifn; infection; populations; renilla; replication; rna; type; virus cache: cord-271970-i35pic5o.txt plain text: cord-271970-i35pic5o.txt item: #266 of 549 id: cord-272051-arz8r204 author: Federico, Maurizio title: HIV-protease inhibitors block the replication of both vesicular stomatitis and influenza viruses at an early post-entry replication step date: 2011-08-15 words: 6787 flesch: 45 summary: However, it is now accepted that this family of inhibitors can also affect the activity of cell proteases. The concept that the activity of cell proteases is part of the mechanisms underlying the replication of many virus species is widely accepted. keywords: cells; effect; fusion; hiv-1; influenza; pis; protease; replication; virus; vsv cache: cord-272051-arz8r204.txt plain text: cord-272051-arz8r204.txt item: #267 of 549 id: cord-272925-xag1yaie author: Carter, Gemma C. title: HIV entry in macrophages is dependent on intact lipid rafts date: 2009-03-30 words: 8182 flesch: 36 summary: These data suggest that macrophage membrane cholesterol is essential for HIV entry, and implicate lipid raft involvement. Therefore, depletion of macrophage membrane cholesterol with MβCD severely inhibits the early steps of productive HIV infection of macrophages. keywords: ccr5; cd4; cells; cholesterol; entry; et al; expression; hiv; infection; levels; lipid; macrophages; membrane; rafts; virus cache: cord-272925-xag1yaie.txt plain text: cord-272925-xag1yaie.txt item: #268 of 549 id: cord-273324-xhpv783y author: Land, Kevin J. title: REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes date: 2018-12-13 words: 7424 flesch: 33 summary: Many donors -for example, Global Fund and implementation partners, including the WHO, UNAIDS and PEPFAR -have helped affected countries with the procurement and introduction of rapid HIV tests and enable early detection and prevent onward transmission. Thus, connectivity solutions can increase quality assurance for POC tests and would allow for centralized and real-time decision-making, even across tiered laboratory systems and during outbreak investigations and global health emergencies. keywords: care; countries; detection; diagnostics; health; hiv; malaria; poc; point; quality; rdts; results; syphilis; testing; tests cache: cord-273324-xhpv783y.txt plain text: cord-273324-xhpv783y.txt item: #269 of 549 id: cord-273777-qb0vp9gr author: Happel, Anna-Ursula title: The Vaginal Virome—Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes? date: 2020-07-30 words: 6253 flesch: 22 summary: Whether a core vaginal virome exists or whether differences in vaginal viruses identified in these studies are due to variable demographic or clinical characteristics of the cohorts, to differences in laboratory or sequencing methods, or to the viral databases and viral annotation tools applied remains unclear. Notably, only 4% of vaginal viruses identified by metagenomic sequencing by Jakobsen et al. (2019) targeted eukaryotes keywords: fgt; health; host; human; infection; microbiota; outcomes; pregnancy; reproductive; vaginal; virome; viruses; women cache: cord-273777-qb0vp9gr.txt plain text: cord-273777-qb0vp9gr.txt item: #270 of 549 id: cord-274019-dao10kx9 author: Rife, Brittany D title: Phylodynamic applications in 21(st) century global infectious disease research date: 2017-05-08 words: 6273 flesch: 23 summary: Despite the limitations to traditional infectious disease epidemiology, major advances in study designs and methods for epidemiological data analysis have been made over the past decade for a multifaceted investigation of the complexity of disease at both the individual and population levels [14, 15] . Combining pathogen genetic data with host population information (e.g., population density and air traffic) in a statistical framework is critical for the reliable assessment of factors potentially associated with pathogen population dynamics and geographic spread. keywords: analysis; bayesian; data; disease; dynamics; epidemiology; factors; global; health; pathogen; phylodynamic; population; spread; transmission cache: cord-274019-dao10kx9.txt plain text: cord-274019-dao10kx9.txt item: #271 of 549 id: cord-274080-884x48on author: Rumlová, Michaela title: In vitro methods for testing antiviral drugs date: 2018-06-30 words: 18015 flesch: 26 summary: Virus-encoded methyltransferases have been identified and characterized in flaviviruses such as Zika virus Coutard et al., 2017; Duan et al., 2017; Munjal et al., 2017; Zhao et al., 2017) , West Nile virus, and dengue virus (Dong et al., 2012) ; rhabdoviruses such as vesicular stomatitis virus (VSV) (Rahmeh et al., 2009 ); coronaviruses such as SARS (Wang et al., 2015b) ; and roniviruses (Zeng et al., 2016) . Alternatively, cleavage products may be monitored by analysis of proteolytic products by mass spectrometric methods (Hu et al., 2015; Joshi et al., 2017; Lathia et al., 2011; Rumlová et al., 2003) , analytical HPLC (Teruya et al., 2016) , or electrochemical methods based on the difference in penetration of substrate and cleavage products through the membrane of a polyionselective sensor (Gemene and Meyerhoff, 2011; Han et al., 1996) . keywords: activity; assay; assembly; binding; capsid; cell; coronavirus; dna; drug; entry; envelope; et al; fluorescence; fusion; genome; hbv; hcv; helicase; hepatitis; host; human; infection; influenza; inhibitors; integrase; kinase; membrane; method; particles; polymerase; protease; protein; replication; rna; screening; specific; target; transcription; type; uncoating; viral; virus; viruses cache: cord-274080-884x48on.txt plain text: cord-274080-884x48on.txt item: #272 of 549 id: cord-274663-zyzgk2z3 author: Chang, Stewart T. title: Next-Generation Sequencing Reveals HIV-1-Mediated Suppression of T Cell Activation and RNA Processing and Regulation of Noncoding RNA Expression in a CD4(+) T Cell Line date: 2011-09-20 words: 7009 flesch: 43 summary: Microarray data on gene modulation by HIV-1 in immune cells: 2000 -2006 Molecular biology of human immunodeficiency virus type 1 Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays Functional genomics analyses of differential macaque peripheral blood mononuclear cell infections by human immunodeficiency virus-1 and simian immunodeficiency virus Cellular gene expression upon human immunodeficiency virus type 1 infection of CD4(ϩ)-T-cell lines Transcriptional profiling in pathogenic and nonpathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization A comparison of massively parallel nucleotide sequencing with oligonucleotide microarrays for global transcription profiling Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling BCL11B is a general transcriptional repressor of the HIV-1 long terminal repeat in T lymphocytes through recruitment of the NuRD complex HIV-1 down-regulates the expression of CD1d via Nef Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles RNA and disease hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs TDP-43: multiple targets, multiple disease mechanisms? Using NGS, we detected small but significant changes in host gene expression affecting T cell function that coincided with the initiation of viral RNA production at 12 h postinfection (hpi). keywords: activation; cell; changes; data; expression; fig; genes; hiv; host; hpi; infected; infection; rna; virus cache: cord-274663-zyzgk2z3.txt plain text: cord-274663-zyzgk2z3.txt item: #273 of 549 id: cord-274688-cr1rvy8u author: Jewell, Britta L title: Potential effects of disruption to HIV programmes in sub-Saharan Africa caused by COVID-19: results from multiple mathematical models date: 2020-08-06 words: 1876 flesch: 42 summary: In sub-Saharan Africa, this increase amounts to a median excess of HIV deaths, across all model estimates, of 296 000 (range 229 023–420 000) if such a high level of disruption occurred. Predicted average relative annual increase in HIV mortality and incidence in 5 years from 1 April 2020 in countries in sub-Saharan Africa that would result from a 6-month disruption of specific HIV services for 50% of the population, with 95% uncertainty bounds. keywords: africa; art; cd4; disruption; hiv; interruption cache: cord-274688-cr1rvy8u.txt plain text: cord-274688-cr1rvy8u.txt item: #274 of 549 id: cord-275677-hbv49e01 author: Ramana, Lakshmi Narashimhan title: Targeting strategies for delivery of anti-HIV drugs date: 2014-10-28 words: 12986 flesch: 38 summary: An immunoliposomal carrier encapsulating the protease inhibitor P11 and surface modified with anti-gp120 was reported to exhibit excellent specificity towards HIV infected cells due to binding of the anti-gp120 to the exposed domains of gp120 present on the surface of HIV infected cells [12] . Actinohivin, a prokaryotic lectin found in actinomycetes was identified to possess anti-HIV activity and was found to specifically target HIV infected cells. keywords: affinity; anti; binding; ccr5; cd4; cells; cxcr4; delivery; drug; gp120; high; hiv; hiv infection; hla; infected; infection; macrophages; nanoparticles; receptor; surface; t cells; targeting; virus cache: cord-275677-hbv49e01.txt plain text: cord-275677-hbv49e01.txt item: #275 of 549 id: cord-275859-ix8du1er author: Mouzakis, Kathryn D. title: HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome date: 2012-12-15 words: 6740 flesch: 42 summary: key: cord-275859-ix8du1er authors: Mouzakis, Kathryn D.; Lang, Andrew L.; Vander Meulen, Kirk A.; Easterday, Preston D.; Butcher, Samuel E. title: HIV-1 frameshift efficiency is primarily determined by the stability of base pairs positioned at the mRNA entrance channel of the ribosome date: 2012-12-15 journal: Nucleic Acids Res DOI: 10.1093/nar/gks1254 sha: doc_id: 275859 cord_uid: ix8du1er The sequence of the frameshift site stemloop was varied to dissect the relative contributions of local and overall RNA stability on HIV-1 frameshift efficiency. keywords: base; efficiency; figure; frameshift; frameshift efficiency; frameshifting; loop; ribosomal; ribosome; rna; site; stability; stem; structure cache: cord-275859-ix8du1er.txt plain text: cord-275859-ix8du1er.txt item: #276 of 549 id: cord-276006-mjjnkqv6 author: Jarach, Natanel title: Polymers in the Medical Antiviral Front-Line date: 2020-07-31 words: 12601 flesch: 37 summary: Some other molecules with antiviral effects are 5-(N-ethyl-N-isopropyl)amiloride (EIPA), verapamil, and diltiazem. Silver (Ag) particles have an antiviral effect even in their metal form; Yamamoto et al. showed that the addition of Ag particles to a cotton textile granted it antiviral effect against Influenza A and Feline Calicivirus [76] . keywords: acid; activity; addition; ammonium; drugs; effect; et al; figure; influenza; ions; metal; nanoparticles; particles; polymers; properties; rna; sulphate; temperature; virus; viruses cache: cord-276006-mjjnkqv6.txt plain text: cord-276006-mjjnkqv6.txt item: #277 of 549 id: cord-276870-gxtvlji7 author: Bobrowski, Tesia title: Learning from history: do not flatten the curve of antiviral research! date: 2020-07-15 words: 5092 flesch: 43 summary: Additionally, modern computational techniques, such as quantitative structure-activity relationship (QSAR) modeling, molecular docking, and machine-learning approaches are being used now in COVID-19 drug discovery efforts [17, 40, 41] . HIVGov 30 AIDSinfo (2018) FDA-Approved HIV Medicines The application of structural optimization strategies in drug design of HIV NNRTIs EASY-HIT: HIV full-replication technology for broad discovery of multiple classes of HIV inhibitors Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets Combined With Standard Treatment/ Standard Treatment in Patients With Suspected and Mild Novel Coronavirus Pneumonia (COVID-19) COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir Pre-exposure Prophylaxis for SARS-Coronavirus-2 HIV epidemiology and the effects of antiviral therapy on longterm consequences Viral evolution and the emergence of SARS coronavirus Immunity Passports' in the Context of COVID-19 Structure of Mpro from COVID-19 virus and discovery of its inhibitors Artificial intelligence and machine learning to fight COVID-19 Mapping the landscape of artificial intelligence applications against Improving Health and Reducing Poverty Trump disbanded NSC pandemic unit that experts had praised CDC to cut by 80 percent efforts to prevent global disease outbreak Tecovirimat for the Treatment of Smallpox Disease Antimicrobial Division Advisory Committee Meeting. keywords: covid-19; data; epidemics; hiv; number; publications; research; response; sars; time cache: cord-276870-gxtvlji7.txt plain text: cord-276870-gxtvlji7.txt item: #278 of 549 id: cord-277417-f71jwdzj author: Geoghegan, Jemma L. title: The phylogenomics of evolving virus virulence date: 2018-10-10 words: 10445 flesch: 33 summary: If only a single mutation is associated with a change in virus virulence, as in the case of WNV, then this change in virulence is likely to be selectively advantageous without an evolutionary trade-off with transmissibility, as a reduction in transmissibility would probably need to be compensated for by additional reciprocal mutations located elsewhere in the genome. To illustrate how a phylogenomic approach can shed light on the evolution of virus virulence, we now briefly outline a number of cases in which it can be or has been applied. keywords: case; determinants; disease; evolution; fitness; host; human; influenza; mutations; selection; species; studies; transmission; virulence; virulence evolution; virus; viruses cache: cord-277417-f71jwdzj.txt plain text: cord-277417-f71jwdzj.txt item: #279 of 549 id: cord-277818-8w15dz20 author: Jaichenco, Andre L. title: Infectious Disease Considerations for the Operating Room date: 2018-02-09 words: 9732 flesch: 31 summary: Gloves protect patients by reducing health care provider hand contamination and the subsequent transmission of pathogens to other children, provided the gloves are changed after providing care to each child. 10 Direct and indirect contacts are the most significant and frequent methods of hospital infection transmission. keywords: anesthesia; blood; care; children; contamination; exposure; gloves; guidelines; hand; health; hygiene; infection; patient; pediatric; prophylaxis; providers; risk; skin; transmission; use cache: cord-277818-8w15dz20.txt plain text: cord-277818-8w15dz20.txt item: #280 of 549 id: cord-278156-zd039ohv author: Dumas, Fabrice title: Membrane organization of virus and target cell plays a role in HIV entry date: 2014-09-01 words: 4844 flesch: 36 summary: Functional rafts in cell membranes Measuring the strength of interaction between the ebola fusion peptide and lipid rafts: implications for membrane fusion and virus infection Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry Campadelli-Fiume, {alpha}V{beta}3-integrin routes herpes simplex virus to an entry pathway dependent on cholesterol-rich lipid rafts and dynamin2 Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1 Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(þ) T cells Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5 Blocking of HIV-1 infection by targeting CD4 to nonraft membrane domains CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry identification of a novel raft localization marker in CD4 Restricted lateral mobility of plasma membrane CD4 impairs HIV-1 envelope glycoprotein mediated fusion Actin-and myosin-driven movement of viruses along filopodia precedes their entry into cells A new classification for HIV-1 Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains Correlation of coreceptor usage and disease progression Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1 HIV requires multiple gp120 molecules for CD4-mediated infection Estimating the threshold surface density of Gp120-CCR5 complexes necessary for HIV-1 envelope-mediated cell-cell fusion Electron tomography of the contact between T cells and SIV/ HIV-1: implications for viral entry Single-Molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution Constitutive cell surface association between CD4 and CCR5 Specific interaction of CXCR4 with CD4 and CD8alpha: functional analysis of the CD4/CXCR4 interaction in the context of HIV-1 envelope glycoprotein-mediated membrane fusion CD4 and CCR5 constitutively interact at the plasma membrane of living cells: a confocal fluorescence resonance energy transfer-based approach Mobility of the human immunodeficiency virus (HIV) receptor CD4 and coreceptor CCR5 in living cells: implications for HIV fusion and entry events Even though literature can be contradictory in some points, it seems to be clear that receptor and co-receptors of HIV virus are confined into domains that could act as ports of entry for HIV viruses. keywords: ccr5; cd4; cell; entry; fusion; hiv; infection; lipid; membrane; virus cache: cord-278156-zd039ohv.txt plain text: cord-278156-zd039ohv.txt item: #281 of 549 id: cord-278174-znc99yos author: Ramsey, Glenn title: Managing recalls and withdrawals of blood components date: 2004-01-31 words: 4904 flesch: 46 summary: Over the past 10 to 15 years, the stricter application of these principles to blood components has led to a growing number of recalls and withdrawals by blood suppliers, as well as a concomitant increase in the numbers of notices sent to transfusion services about blood products they have received. Furthermore, because platelets and red blood cells have a short shelf life and because hospitals do not keep a large reserve of blood components in storage, most of these notices about nonconforming blood products are often received after the units had been transfused. keywords: blood; components; donor; fda; hiv; recalls; risk; testing; transfusion; units cache: cord-278174-znc99yos.txt plain text: cord-278174-znc99yos.txt item: #282 of 549 id: cord-278456-gsv6dh36 author: Qureshi, Abid title: AVCpred: an integrated web server for prediction and design of antiviral compounds date: 2016-09-09 words: 3467 flesch: 45 summary: [41] However, till date there is no web server/software, which can regressively predict the percentage inhibition value of a compound against different human viruses under a single platform. The latter were then used as input for support vector machine (in regression mode) to develop QSAR models for different viruses as well as a general model for other viruses. keywords: avcs; compounds; descriptors; models; qsar; virus; viruses; web cache: cord-278456-gsv6dh36.txt plain text: cord-278456-gsv6dh36.txt item: #283 of 549 id: cord-278831-gwnfcfvk author: Taniwaki, Sueli Akemi title: Virus–host interaction in feline immunodeficiency virus (FIV) infection date: 2013-08-02 words: 6312 flesch: 37 summary: In: ICTVdB -The Universal Virus Database Feline immunodeficiency virus infection: an overview Vaccination against the feline immunodeficiency virus: the road not taken Nucleotide sequence and genomic organization of feline immunodeficiency virus Transmission and immunopathogenesis of FIV in cats as a model for HIV Lentivirus-induced immune dysregulation Restriction of feline retroviruses: lessons from cat APOBEC3 cytidine deaminases and TRIM5alpha proteins Nucleotide sequence of feline immunodeficiency virus: classification of Japanese isolates into two subtypes which are distinct from non-Japanese subtypes Comparative study of the cell tropism of feline immunodeficiency virus isolates of subtype A, B and D classified on the basis of the env gene V3-V5 sequence Genetic diversity of Argentine isolates of feline immunodeficiency virus Phylogenetic analysis of five Portuguese strains of FIV Phylogenetic analysis of Vietnamese isolates of feline immunodeficiency virus: genetic diversity of subtype C Occurrence of feline immunodeficiency virus infection in cats Seroprevalence of feline leukemia virus and feline immunodeficiency virus infection among cats in North America and risk factors for seropositivity Quality of different in-clinic test systems for feline immunodeficiency virus and feline leukemia virus infection Retroviral infections of small animals Feline immunodeficiency, ABCD guidelines on prevention and management Lessons from the cat: development of vaccines against lentiviruses Clinical and pathological findings in feline immunodeficiency virus experimental infection A longitudinal study of feline immunodeficiency virus-specific cytotoxic T lymphocytes in experimentally infected cats, using antigen-specific induction Vaccine protection against feline immunodeficiency virus: setting the challenge Chemokine receptors and co-stimulatory molecules: unravelling feline immunodeficiency virus infection. FIV infection causes progressive immunosuppression that results in the development of the acquired immunodeficiency syndrome (AIDS) in cats, which, similar to human HIV infection, increases susceptibility to secondary and opportunistic infections. keywords: cats; cd4; cells; feline; fiv; hiv; immunodeficiency; infection; receptor; response; virus cache: cord-278831-gwnfcfvk.txt plain text: cord-278831-gwnfcfvk.txt item: #284 of 549 id: cord-278876-il7g78w1 author: Akkina, Ramesh title: 2016 International meeting of the Global Virus Network date: 2017-03-16 words: 7545 flesch: 31 summary: Hideki Hasegawa, a GVN center director at the National Institute of Infectious Diseases in Tokyo, explained that secretory IgA antibodies on mucosal surfaces play an important role in protection against influenza virus infection. Such studies will make it possible to assess the role of additional effector mechanism in protecting against influenza virus infection and to evaluate the importance of reducing the immunodominance of the variable HA head domain. keywords: antibodies; antibody; cells; center; development; ebola; global; gvn; hiv; human; infection; influenza; institute; research; university; vaccine; virology; virus; viruses cache: cord-278876-il7g78w1.txt plain text: cord-278876-il7g78w1.txt item: #285 of 549 id: cord-279828-es498qul author: Boulle, Andrew title: Risk factors for COVID-19 death in a population cohort study from the Western Cape Province, South Africa date: 2020-08-29 words: 3653 flesch: 35 summary: COVID-19 in patients with HIV: clinical case series Clinical features and outcomes of HIV patients with coronavirus disease 2019 COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients COVID-19 in patients with HIV A Case Series of Five People Living with HIV Hospitalized with COVID-19 in Clinical characteristics and outcomes in people living with HIV hospitalized for COVID-19 Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort OpenSAFELY: factors associated with COVID-19 death in 17 million patients Dysregulation of immune response in patients with COVID-19 in Wuhan, China Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study Could HIV infection alter the clinical course of SARS-CoV-2 infection? We also calculated the standardized mortality ratio (SMR) of the actual number of COVID-19 deaths in PLWH vs. the number that would be expected if PLWH had the same risk of COVID-19 death as HIV-negative people of the same age and sex. keywords: art; cases; covid-19; covid-19 death; death; hiv; mortality; patients; plwh; risk; sector; tuberculosis cache: cord-279828-es498qul.txt plain text: cord-279828-es498qul.txt item: #286 of 549 id: cord-279849-zzkliu76 author: DaPalma, T. title: A systematic approach to virus–virus interactions date: 2010-01-20 words: 8236 flesch: 24 summary: on a worldwide geographical scale Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo An equine infectious anemia virus variant superinfects cells through novel receptor interactions Specific inhibition of the PKR-mediated antiviral response by the murine cytomegalovirus proteins m142 and m143 Herpes simplex virus types 1 and 2 completely help adenovirus-associated virus replication Recombination in HIV: an important viral evolutionary strategy A prospective study of dengue infections in Bangkok Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infection Genital herpes and human immunodeficiency virus: double trouble The interaction between herpes simplex virus and human immunodeficiency virus Nonreciprocal pseudotyping: murine leukemia virus proteins cannot efficiently package spleen necrosis virus-based vector RNA Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung Anatomical mapping of human herpesvirus reservoirs of infection Systemic movement of a movement-deficient strain of Cucumber mosaic virus in zucchini squash is facilitated by a cucurbit-infecting potyvirus Reactivation and recombination of multiple cytomegalovirus strains from individual organ donors A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes Coxsackie B virus infection and onset of childhood diabetes Dynamic effects of antibody-dependent enhancement on the fitness of viruses A case-control study of group B Coxsackievirus immunoglobulin M antibody prevalence and HLA-DR antigens in newly diagnosed cases of insulin-dependent diabetes mellitus Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. The phenomenon of ADE is not unique to dengue virus infections. keywords: cell; disease; et al; expression; gene; herpesvirus; hiv; host; human; immune; infection; interactions; protein; replication; type; virus; viruses; vvi cache: cord-279849-zzkliu76.txt plain text: cord-279849-zzkliu76.txt item: #287 of 549 id: cord-281367-qm5a5c4b author: Des Jarlais, Don C title: Patterns of HIV prevalence among injecting drug users in the cross-border area of Lang Son Province, Vietnam, and Ning Ming County, Guangxi Province, China date: 2005-08-24 words: 3589 flesch: 54 summary: Prevention of risky injections among border crossing IDUs will require very good supplies of sterile injection equipment on both sides. HIV infection has been reported among IDUs in over 100 countries [1] . keywords: border; china; cross; drug; hiv; idus; lang; use; vietnam cache: cord-281367-qm5a5c4b.txt plain text: cord-281367-qm5a5c4b.txt item: #288 of 549 id: cord-281941-97t45w73 author: Zhou, Daijun title: Cyclophilin A and viral infections date: 2012-08-10 words: 3416 flesch: 38 summary: Our study showed that RV infection triggered a temporal increase of CyPA protein. Therefore, packaging of host CyPA into HIV particles is an important step in HIV morphogenesis and essential for HIV replication. keywords: cells; cyclophilin; cypa; hepatitis; infection; influenza; protein; replication; virus cache: cord-281941-97t45w73.txt plain text: cord-281941-97t45w73.txt item: #289 of 549 id: cord-282063-tkp1tifx author: Saberi, Parya title: Research in the Time of Coronavirus: Continuing Ongoing Studies in the Midst of the COVID-19 Pandemic date: 2020-04-18 words: 1950 flesch: 30 summary: For longitudinal research, reloadable debit cards are a convenient method of payment and have been shown to be highly feasible and acceptable by research participants [24] . In the era of pandemics, such SARS-CoV-2, there is a need to continue research activities, while keeping research participants and staff safe. keywords: adherence; health; hiv; participants; recruitment; research; study cache: cord-282063-tkp1tifx.txt plain text: cord-282063-tkp1tifx.txt item: #290 of 549 id: cord-282675-s4zmffj3 author: Sagaon-Teyssier, Luis title: Assessment of mental health outcomes and associated factors among workers in community-based HIV care centers in the early stage of the COVID-19 outbreak in Mali date: 2020-10-15 words: 6933 flesch: 43 summary: RAND Corporation Poor performance of community health workers in Kalabo District Staff attrition among community health workers in home-based care programmes for people living with HIV and AIDS in western Kenya Health workers, quality of care, and child health: Simulating the relationships between increases in health staffing and child length Focussing on the wellbeing of health care workers in sub-Saharan Africa Overworked? The deleterious impact on HCW mental health [14, 15] because of the these structural problems and unpreparedness to contain COVID-19 constitutes a serious public health issue [16] . keywords: anxiety; care; centers; covid-19; depression; hcw; health; healthcare; hiv; insomnia; mali; mental; outbreak; workers cache: cord-282675-s4zmffj3.txt plain text: cord-282675-s4zmffj3.txt item: #291 of 549 id: cord-283127-jetmocvk author: Wang, Denong title: Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic Origins date: 2015-03-12 words: 4002 flesch: 39 summary: Antibody domain exchange is an immunological solution to carbohydrate cluster recognition Rational antibody-based HIV-1 vaccine design: Current approaches and future directions The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120 The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120 A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1 PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of cd4 Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Broad neutralization coverage of HIV by multiple highly potent antibodies Synthetic carbohydrate antigens for HIV vaccine design Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1 Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Glycan arrays lead to the discovery of autoimmunogenic activity of SARS-CoV The genome sequence of the SARS-associated coronavirus Characterization of a novel coronavirus associated with severe acute respiratory syndrome The SARS-COV S glycoprotein: Expression and functional characterization Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein Alpha-(1-3)-and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins Mannose-specific plant lectins from the amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle Expression, glycoform characterization, and antibody-binding of HIV-1 V3 glycopeptide domain fused with human IgG1-Fc Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens The lectin helix pomatia agglutinin recognizes O-GlcNAc containing glycoproteins in human breast cancer Anti-glycan antibodies or biotinylated lectins were pre-titrated in 1% BSA, PBST for ELISA. keywords: binding; carbohydrate; cov; epitopes; glycan; gna; moieties; sars; specific; virus cache: cord-283127-jetmocvk.txt plain text: cord-283127-jetmocvk.txt item: #292 of 549 id: cord-283346-0v4b6do2 author: Ansari, Abdul Wahid title: Host chemokine (C-C motif) ligand-2 (CCL2) is differentially regulated in HIV type 1 (HIV-1)-infected individuals date: 2006-08-17 words: 4357 flesch: 41 summary: Genes up-regulated in the viremic state, in particular CCL2, presumably serve as potential enhancing factors in HIV-1 replication, represented by high viral load in HIV-1 viremic patients. In this study, we report that HIV-1 viremic patients show an altered expression of key inflammatory cytokines and chemokines as compared with aviremic individuals. keywords: ccl2; cells; expression; genes; hiv-1; host; infection; patients; rna; viremic cache: cord-283346-0v4b6do2.txt plain text: cord-283346-0v4b6do2.txt item: #293 of 549 id: cord-284128-3obc5k5u author: Ahmed, Ali title: Concerns of HIV-positive migrant workers in COVID-19 pandemic: A call for action date: 2020-09-08 words: 1455 flesch: 44 summary: Some countries, such as Thailand and Spain have ensured equal access to health care for all legal and illegal WHO need to issue advisory to all the countries for timely access of antiretroviral therapy to HIV positive migrants regardless of their legal status. Studies conducted in Australia and Europe respectively show that migrants are behind in fulfilling the UNAIDS 90-90-90 target (a strategy where 90% of HIV patients should be aware of their HIV status, receive sustained antiretroviral therapy and achieve viral suppression by the year 2020) and more prone to being lost to follow-up ART treatment when compared to non-migrant population [11, 12] . keywords: covid-19; health; hiv; migrants cache: cord-284128-3obc5k5u.txt plain text: cord-284128-3obc5k5u.txt item: #294 of 549 id: cord-284385-ster02o9 author: Gambichler, Thilo title: On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19 date: 2020-07-01 words: 7170 flesch: 33 summary: The INVIDIa study State of the art about influenza vaccination for advanced cancer patients receiving immune checkpoint inhibitors: when common sense is not enough Severe relapse of vaccineinduced Guillain-Barré syndrome after treatment with nivolumab Pd-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination Safety of inactivated influenza vaccine in cancer patients receiving immune checkpoint inhibitors Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events Immune-Mediated adverse events following influenza vaccine in cancer patients receiving immune checkpoint inhibitors Influenza vaccination in patients with lung cancer receiving anti-programmed death receptor 1 immunotherapy does not induce immune-related adverse events Safety of influenza vaccine in patients with cancer receiving pembrolizumab Immune-Related adverse events in patients with cancer receiving influenza vaccination and immune checkpoint inhibitors Immunogenicity of influenza vaccination in patients with cancer receiving immune checkpoint inhibitor Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors Single-cell RNA-seq identifies a PD-1 hi ILC progenitor and defines its development pathway COVID-19 Dashboard by the center for systems science and engineering (CSSE) at Johns Hopkins University (JHU) Covid-19: risk factors for severe disease and death Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19) key: cord-284385-ster02o9 authors: Gambichler, Thilo; Reuther, Judith; Scheel, Christina H; Becker, Jürgen Christian title: On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19 date: 2020-07-01 journal: J Immunother Cancer DOI: 10.1136/jitc-2020-001145 sha: doc_id: 284385 cord_uid: ster02o9 The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19. keywords: cancer; cell; checkpoint; covid-19; hepatitis; hiv; ici; immune; infection; influenza; inhibitors; lymphocytes; patients; pd-1; treatment cache: cord-284385-ster02o9.txt plain text: cord-284385-ster02o9.txt item: #295 of 549 id: cord-284409-xiyeceib author: Prabakaran, Ponraj title: The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires date: 2014-08-28 words: 5279 flesch: 33 summary: We have further hypothesized that the immunogenicity of highly conserved epitopes on the HIV-1 envelope glycoproteins (Envs) may be reduced or eliminated by their very weak or absent interactions with germline antibodies and immune responses leading to the elicitation of bnAbs may not be initiated and/or sustained. This led us to the hypothesis that the immunogenicity of the highly conserved epitopes on the HIV-1 native envelope glycoproteins (Envs) is reduced or eliminated by their very weak or absent interactions with germline antibodies, which could not initiate and/or sustain immune responses leading to elicitation of bnAbs: even if immune responses are initiated and sustained, the maturation pathways are so complex that help and long times may be needed for their elicitation. keywords: amino; antibodies; antibody; bnabs; germline; heavy; hiv-1; intermediates; maturation; vrc01 cache: cord-284409-xiyeceib.txt plain text: cord-284409-xiyeceib.txt item: #296 of 549 id: cord-284523-lknyehsa author: da Mata, Élida Cleyse Gomes title: Antiviral activity of animal venom peptides and related compounds date: 2017-01-06 words: 7093 flesch: 38 summary: (6) The peptides hecate and TVS-LAO act in the post-translation process, in the cleavage of the GAG/POL protein precursor thus interfering in the assembly of the viral capsid and in the organization of the polymerase complex with viral nucleic acid, or (ii) production of cytokines that stimulate the action of T cytotoxic cells, and NK cells, and even host cell expression of the major histocompatibility complex molecules, in order to present viral peptides to the other cells of the immune system [16] . key: cord-284523-lknyehsa authors: da Mata, Élida Cleyse Gomes; Mourão, Caroline Barbosa Farias; Rangel, Marisa; Schwartz, Elisabeth Ferroni title: Antiviral activity of animal venom peptides and related compounds date: 2017-01-06 journal: J Venom Anim Toxins Incl Trop Dis DOI: 10.1186/s40409-016-0089-0 sha: doc_id: 284523 cord_uid: lknyehsa Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. keywords: acid; activity; amino; antiviral; cd4; cells; compounds; gp120; hiv; host; infection; peptides; residues; snake; table; venom; virus cache: cord-284523-lknyehsa.txt plain text: cord-284523-lknyehsa.txt item: #297 of 549 id: cord-284608-ba7wq52t author: Sias, Catia title: Alpha, Beta, gamma human PapillomaViruses (HPV) detection with a different sets of primers in oropharyngeal swabs, anal and cervical samples date: 2019-03-04 words: 5652 flesch: 51 summary: Currently, there are no guidelines recommending HPV oral cavity screening as a mandatory test, and it remains unknown which HPV types should be included in HPV screening programs. In addition, it remains unknown which HPV types should be included in oral cavity screening. keywords: anal; detection; hiv; hpv; human; prevalence; samples; swabs; types cache: cord-284608-ba7wq52t.txt plain text: cord-284608-ba7wq52t.txt item: #298 of 549 id: cord-285151-zynor0b2 author: Eisenhut, Michael title: Neopterin in Diagnosis and Monitoring of Infectious Diseases date: 2013-12-08 words: 6009 flesch: 28 summary: Successful highly active antiretroviral therapy is associated with a decrease in neopterin levels. Testing of 328 samples of 29 HIV infected individuals found that 44/68 (64.7%) of samples, which were HIV-1 RNA and p24 antigen positive had elevated neopterin levels (>10 nmol/L). keywords: csf; hepatitis; hiv; infection; levels; marker; neopterin; patients; serum; treatment; tuberculosis; urinary; virus cache: cord-285151-zynor0b2.txt plain text: cord-285151-zynor0b2.txt item: #299 of 549 id: cord-285430-o086q2qa author: Gribble, Karleen title: Mistakes from the HIV pandemic should inform the COVID-19 response for maternal and newborn care date: 2020-07-25 words: 2625 flesch: 44 summary: Policy makers in the developing world followed suit and HIV-positive women were supplied with free infant formula despite there being no knowledge of the magnitude of risk of HIV transmission through breastfeeding [8] . It is clear that in order to maximise infant health and wellbeing, COVID-19 policies should support skin-to-skin contact, maternal proximity, and breastfeeding. keywords: breastfeeding; covid-19; hiv; infant; pandemic; transmission cache: cord-285430-o086q2qa.txt plain text: cord-285430-o086q2qa.txt item: #300 of 549 id: cord-285443-9y2kkmby author: Pessi, Antonello title: Cholesterol‐conjugated peptide antivirals: a path to a rapid response to emerging viral diseases date: 2014-10-20 words: 5049 flesch: 34 summary: Emerging and reemerging diseases: a historical perspective Emerging viral diseases The World Health Report Global trends in emerging infectious diseases Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the coronavirus study group World struggles to stop Ebola Identification of a novel coronavirus in patients with severe acute respiratory syndrome Characterization of a novel coronavirus associated with severe acute respiratory syndrome SARS: systematic review of treatment effects Mechanisms of viral membrane fusion and its inhibition Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain Analysis of a peptide inhibitor of paramyxovirus (NDV) fusion using biological assays, NMR, and molecular modeling Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein Development of antiviral fusion inhibitors: short modified peptides derived from the transmembrane glycoprotein of feline immunodeficiency virus Peptide inhibitors targeting virus-cell fusion in class I enveloped viruses Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency Peptides corresponding to the heptad repeat sequence of human parainfluenza virus fusion protein are potent inhibitors of virus infection A synthetic peptide corresponding to a conserved heptad repeat domain is a potent inhibitor of Sendai virus-cell fusion: an emerging similarity with functional domains of other viruses Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein Peptide-based inhibitors of the HIV envelope protein and other class I viral fusion proteins Inhibition of Ebola virus entry by a C-peptide targeted to endosomes Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion Inhibition of Hendra virus fusion Inhibition of measles virus infection and fusion with peptides corresponding to the leucine zipper region of the fusion protein Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors LearnCoil-VMF: computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins MultiCoil2: predicting coiled coils and their oligomerization states from sequence in the twilight zone MultiCoil: a program for predicting two-and three-stranded coiled coils The complete genome sequence of severe acute respiratory syndrome coronavirus strain HKU-39849 (HK-39) Structural characterization of the SARS-coronavirus spike S fusion protein core Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the Nipah virus membrane fusion cascade Kinetic dependence of paramyxovirus entry inhibition Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1 Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity Remodeling of gp41-C34 peptide leads to highly effective inhibitors of the fusion of HIV-1 with target cells Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism Short constrained peptides that inhibit HIV-1 entry Hydrocarbon doublestapling remedies the proteolytic instability of a lengthy peptide therapeutic Design and evaluation of sifuvirtide, a novel HIV-1 fusion inhibitor Lipid rafts are involved in SARS-CoV entry into Vero E6 cells Cholesterol enhances mouse hepatitis virus-mediated cell fusion A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit Cholesterol removal by methyl-beta-cyclodextrin inhibits poliovirus entry The major cellular sterol regulatory pathway is required for Andes virus infection Lipid rafts play an important role in the early stage of severe acute respiratory syndrome-coronavirus life cycle Cholesterol-rich lipid rafts are required for release of infectious human respiratory syncytial virus particles Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 Cholesterol dependence of varicella-zoster virion entry into target cells Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion Plasma membrane rafts play a critical role in HIV-1 assembly and release Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells Human immunodeficiency virus impairs reverse cholesterol transport from macrophages Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux The HIV lipidome: a raft with an unusual composition Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors New clues to understanding HIV nonprogressors: low cholesterol blocks HIV trans infection Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts Galactosylceramide domain microstructure: impact of cholesterol and nucleation/growth conditions Lipid composition and fluidity of the human immunodeficiency virus Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes Role of lipid rafts in virus replication keywords: cholesterol; conjugation; entry; fusion; inhibitors; lead; lipid; membrane; peptide; protein; virus cache: cord-285443-9y2kkmby.txt plain text: cord-285443-9y2kkmby.txt item: #301 of 549 id: cord-285505-8norumv6 author: Vere Hodge, R. Anthony title: Meeting report: 27th International conference on antiviral research, in Raleigh, NC, USA date: 2014-09-16 words: 10298 flesch: 57 summary: These are followed by brief summaries of the keynote addresses and the three mini-symposia on 'Hepatitis B virus', 'Research Triangle Park' and 'Challenges in HIV infection, treatment and prevention'. Although this patient continues to have no sign of HIV infection, this is hardly a viable treatment option for most HIV-infected patients. keywords: activity; antiviral; cells; dna; drug; hbv; hiv; infection; nucleotide; phase; polymerase; prodrug; replication; research; rna; studies; tdf; therapy; treatment; trial; usa; virus cache: cord-285505-8norumv6.txt plain text: cord-285505-8norumv6.txt item: #302 of 549 id: cord-285603-f4572w5m author: Ortega, Joseph T. title: Class A G Protein-Coupled Receptor Antagonist Famotidine as a Therapeutic Alternative against SARS-CoV2: An In Silico Analysis date: 2020-06-24 words: 5999 flesch: 42 summary: However, weak binding affinity of famotidine to these proteases suggests that a successful famotidine therapy could likely be achieved only in combination with other antiviral drugs. Thus, it seems that, similarly to ribavirin, the best therapeutic effect of famotidine could be achieved in combination therapy with other antiviral drugs [64, 65] . keywords: analysis; binding; cov2; drugs; famotidine; hiv; inhibitors; lopinavir; protease; replication; sars; viral cache: cord-285603-f4572w5m.txt plain text: cord-285603-f4572w5m.txt item: #303 of 549 id: cord-285898-rtqkvf63 author: Padberg, Stephanie title: Anti-infective Agents date: 2014-09-29 words: 24011 flesch: 39 summary: Results of a population-based Hungarian case-control study A case-control teratological study of spiramycin, roxithromycin, oleandomycin and josamycin A teratological study of lincosamides A population-based case-control teratologic study of oral oxytetracycline treatment during pregnancy A teratological study of aminoglycoside antibiotic treatment during pregnancy A population-based case-control teratologic study of oral chloramphenicol treatment during pregnancy Augmentin treatment during pregnancy and the prevalence of congenital abnormalities: a population-based case-control teratologic study Use of cephalosporins during pregnancy and in the presence of congenital abnormalities: a population-based, case-control study The teratogenic risk of trimethoprim-sulfonamides: a population based case-control study Nitrofurantoin and congenital abnormalities A population-based case-control study of the safety of oral anti-tuberculosis drug treatment during pregnancy A population-based case-control teratological study of vaginal econazole treatment during pregnancy A population-based case-control teratological study of oral nystatin treatment during pregnancy A case-control teratological study of vaginal natamycin treatment during pregnancy Preterm birth reduction after clotrimazole treatment during pregnancy Population-based case-control teratologic study of topical miconazole A population-based case-control study of oral griseofulvin treatment during pregnancy Tolnaftate spray treatment during pregnancy Effect of mebendazole therapy during pregnancy on birth outcome Periconceptional exposure to efavirenz and neural tube defects First-trimester itraconazole exposure and pregnancy outcome: a prospective cohort study of women contacting teratology information services in Italy Use of amphotericin B during pregnancy: case report and review The safety of the combination artesunate and pyrimethamine-sulfadoxine given during pregnancy Birth outcome of 1886 pregnancies after exposure to phenoxymethylpenicillin in utero The effects of telbivudine in late pregnancy to prevent intrauterine transmission of the hepatitis B virus: a systematic review and meta-analysis Pregnancy outcome after gestational exposure to mebendazole: a prospective controlled cohort study Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study Genotoxicity and carcinogenicity of metronidazole Association between maternal fever and psychological/behavior outcomes: a hypothesis Safety of oseltamivir in pregnancy: a review of preclinical and clinical data Postmarketing surveillance of medications and pregnancy outcomes: clarithromycin and birth malformations Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents Increased risk of severe infant anemia after exposure to maternal HAART Pregnancy outcome following maternal use of zanamivir or oseltamivir during the 2009 influenza A/H1N1 pandemic: a national prospective surveillance study Europeans Guidelines for treatment of HIVinfected adults in Europe Hyperthermia and birth defects A retrospective review of ampicillin-sulbactam and amoxicillin + clavulanate vs cefazolin/cephalexin and erythromycin in the setting of preterm premature rupture of membranes: maternal and neonatal outcomes A prospective controlled multicentre study of clarithromycin in pregnancy Effect of quinine therapy on plasma glucose and plasma insulin levels in pregnant women infected with Plasmodium falciparum malaria in Gezira state Cryptococcal pneumonia complicating pregnancy Exposure to antiretroviral therapy in utero or early life: the health of uninfected children born to HIV-infected women Fosfomycin versus other antibiotics for the treatment of cystitis: a meta-analysis of randomized controlled trials Hematologic effects of maternal antiretroviral therapy and transmission prophylaxis in HIV-1-exposed uninfected newborn infants Birth defects in a national cohort of pregnant women with HIV infection in Italy Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis Safety of efavirenz in first-trimester of pregnancy: a systematic review and meta-analysis of outcomes from observational cohorts Myelomeningocele in a child with intrauterine exposure to efavirenz Successful use of darunavir, etravirine, enfuvirtide and tenofovir/emtricitabine in pregnant woman with multiclass HIV resistance Maternal exposure to prescription and non-prescription pharmaceuticals or drugs of abuse and risk of craniosynostosis Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial Placental transfer and pharmacokinetics of lopinavir and other protease inhibitors in combination with nevirapine at delivery Acyclovir pregnancy registry and valacyclovir pregnancy registry: Interim report for 1 Exposure to nitrofurantoin during the first trimester of pregnancy and the risk for major malformations Quinolone arthropathy -acute toxicity to immature articular cartilage Edwards: discoverer of maternal hyperthermia as a human teratogen Pharmacokinetics of sulfadoxinepyrimethamine in HIV-infected and uninfected pregnant women in Western Kenya Pharmacokinetics of oseltamivir according to trimester of pregnancy Maternal and neonatal outcomes after antepartum treatment of influenza with antiviral medications Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial Inadvertent exposure of pregnant women to ivermectin and albendazole during mass drug administration for lymphatic filariasis Lack of risk of adverse birth outcomes after deworming in pregnant women A prospective and open-label study for the efficacy and safety of telbivudine in pregnancy for the prevention of perinatal transmission of hepatitis B virus infection Lack of tumors in infants with perinatal HIV-1 exposure and fetal/neonatal exposure to zidovudine Review of beta-lactam antibiotics in pregnancy. ORACLE Collaborative Group Antifungal therapy during pregnancy Is gentamicin ototoxic to the fetus? Short-acting sulfonamides near term and neonatal jaundice Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection Prevalence of congenital anomalies in infants with in utero exposure to antiretrovirals No association between griseofulvin and conjoined twinning Drug rash with eosinophilia and systemic symptoms syndrome and renal toxicity with a nevirapine-containing regimen in a pregnant patient with human immunodeficiency virus Investigation of metronidazole use during pregnancy and adverse birth outcomes Use of antiretroviral therapy in pregnant HIVinfected women and the risk of premature delivery: a meta-analysis Transplacental passage of vancomycin in noninfected term pregnant women Serum erythromycin levels in pregnancy Birth outcome following maternal use of fluoroquinolones Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria Multidrug-resistant tuberculosis in pregnancy: case report and review of the literature Drug hepatotoxicity in pregnancy Increased risk of low birthweight and small for gestational age infants among women with tuberculosis Maternal exposure to amoxicillin and the risk of oral clefts Safety of macrolides during pregnancy Association of high-dose bifonazole administration during early pregnancy and severe limb reduction defects in the newborn Safety of telbivudine treatment for chronic hepatitis B for the entire pregnancy Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype Erythromycin use during pregnancy in relation to pyloric stenosis Congenital defects among children born to women under supervision or treatment for pulmonary tuberculosis Successful use of dapsone in refractory pregnancy-associated idiopathic thrombocytopenic purpura Maternal and infant use of erythromycin and other macrolide antibiotics as risk factors for infantile hypertrophic pyloric stenosis First trimester use of macrolides and risk of major malformations {OTIS Abstract} Case report: nucleoside analogue-induced lactic acidosis in the third trimester of pregnancy Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1 Assessment of infant development during an 18-month follow-up after treatment of infections in pregnant women with cefuroxime axetil Safety of artemether-lumefantrine in pregnant women with malaria: results of a prospective cohort study in Zambia Safety and efficacy of fosamprenavir in human immunodeficiency virus-infected pregnant women Transplacental passage of protease inhibitors at delivery Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole A systematic review of the impact of malaria prevention in pregnancy on low birth weight and maternal anemia Hepatotoxicity of erythromycin estolate during pregnancy Preliminary data on exposure to mebendazole during pregnancy {Abstract} A randomized comparison of artesunate-atovaquoneproguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy Randomized comparison of mefloquine-artesunate versus quinine in the treatment of multidrug-resistant falciparum malaria in pregnancy Artemisinin antimalarials in pregnancy: a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria A randomised controlled trial of artemetherlumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy The effects of quinine and chloroquine antimalarial treatments in the first trimester of pregnancy High neonatal concentrations of raltegravir following transplacental transfer in HIV-1 positive pregnant women Treatment of vulvovaginal candidiasis in pregnancy. keywords: animal; birth; case; combination; data; defects; e.g.; effects; evidence; exposure; fetus; hiv; infections; malaria; malformations; population; pregnancy; pregnancy registry; recommendation; registry; risk; safety; second; studies; study; teratogenic; therapy; treatment; trimester; trimester exposure; use; women cache: cord-285898-rtqkvf63.txt plain text: cord-285898-rtqkvf63.txt item: #304 of 549 id: cord-286194-2emwfx89 author: Mirzaei, Hossein title: COVID-19 Among People Living with HIV: A Systematic Review date: 2020-07-30 words: 3049 flesch: 43 summary: From an initial 547 publications and 75 reports, 25 studies provided specific information on COVID-19 patients living with HIV. First, while a large proportion of COVID-19 patients are asymptomatic or have mild symptoms, all of the patients in this review were symptomatic, and most were admitted to a hospital. keywords: case; covid-19; disease; hiv; infection; patients; studies cache: cord-286194-2emwfx89.txt plain text: cord-286194-2emwfx89.txt item: #305 of 549 id: cord-286219-qcx5ehnh author: Calistri, Arianna title: The Ubiquitin-Conjugating System: Multiple Roles in Viral Replication and Infection date: 2014-05-06 words: 10214 flesch: 35 summary: First of all, viral proteins have been described that can modify the substrate specificity of cellular Ub ligases. In addition to p53 and pRB, another protein complex involved in cell cycle control, the anaphase-promoting complex (APC) is emerging as a key target for viral proteins. keywords: budding; cells; cellular; complex; cycle; degradation; human; ligase; proteasome; protein; replication; role; tetherin; ubiquitin; ubiquitination; virus; viruses; vpr; vpu cache: cord-286219-qcx5ehnh.txt plain text: cord-286219-qcx5ehnh.txt item: #306 of 549 id: cord-286352-uftl1mx5 author: Baril, Martin title: The Frameshift Stimulatory Signal of Human Immunodeficiency Virus Type 1 Group O is a Pseudoknot date: 2003-08-15 words: 5695 flesch: 48 summary: The frameshift efficiencies of the constructs containing these mutations were assessed in vitro and in cultured cells and are presented in Figure 4 (b) (see also Table 1 To provide an independent support for the pseudoknot structure in subtype MVP5180 of HIV-1 group O frameshift stimulatory signal, we made a structural probing analysis of an RNA fragment encompassing the gag/pol frameshift region of this subtype. We can thus propose that the protease of HIV-1 group O viruses could be less active than group M protease, and that group O viruses require a Gag -Pol to Gag ratio higher than that of group M members, so as to incorporate more Gag -Pol in their virions for an optimal fitness during infection. keywords: frameshift; group; group o; loop; pseudoknot; rna; sequence; signal; stem; structure cache: cord-286352-uftl1mx5.txt plain text: cord-286352-uftl1mx5.txt item: #307 of 549 id: cord-286574-t9z2ynt5 author: None title: Speaker presentations date: 2017-09-30 words: 14868 flesch: 37 summary: Increased mortality and morbidity in resistant infections is due to treatment failure of antibiotic therapy which is associated with bacterial fitness, greater severity of underlying illness, delays in initiating effective therapy and lack of effective therapy (Friedman et al. 2016) . In this study, emticitrabine/tenofovir disoproxil fumarate (FTC/TDF or Truvada ® ) safely achieved a 44% per-protocol reduction in new HIV infections. keywords: amr; antibiotics; care; clones; colistin; control; countries; development; disease; drug; gram; health; hiv; impact; infection; mortality; mrsa; new; patients; pneumonia; prep; resistance; risk; sfts; species; strains; studies; testing; therapy; time; treatment; use cache: cord-286574-t9z2ynt5.txt plain text: cord-286574-t9z2ynt5.txt item: #308 of 549 id: cord-286711-nr6vnl9h author: None title: Other viruses causing gastroenteritis date: 2003-12-31 words: 2187 flesch: 37 summary: key: cord-286711-nr6vnl9h authors: nan title: Other viruses causing gastroenteritis date: 2003-12-31 journal: Perspectives in Medical Virology DOI: 10.1016/s0168-7069(03)09037-2 sha: doc_id: 286711 cord_uid: nr6vnl9h Publisher Summary Besides the viruses producing the majority of human viral gastroenteritis, other viruses infect more rarely but are sometimes able to cause epidemics. Cytomegalovirus DNA level on biopsy specimens during treatment of cytomegalovirus gastrointestinal disease Cytomagalovirus colitis in AIDS: presentation in 44 patients and a review of the literature Coronaviridae HIVs and their replication Detection and characterization of bisegmented double stranded RNA viruses (Picobirnavirus) in human faecal specimes Detection and characterization of a novel bisegmented double-stranded RNA virus (Picobirnavirus) from rabbit faeces Human enteric coronaviruses: antigenic relatedness to human coronavirus OC43 and possible etiologic role in viral gastroenteritis Diarrhea and enteric emerging viruses in HIV-infected patients Enteric viruses and diarrhoea in HIV-infected patients Human immunodeficiency virus infection of enterocytes and mononuclear cells in human jejunal mucosa Coronaviruses. keywords: cause; diarrhoea; family; patients; viruses cache: cord-286711-nr6vnl9h.txt plain text: cord-286711-nr6vnl9h.txt item: #309 of 549 id: cord-286719-1xjmlwqr author: Draz, Mohamed Shehata title: Applications of gold nanoparticles in virus detection date: 2018-02-15 words: 19000 flesch: 33 summary: In addition, we provide a general summary of the contributions of AuNPs to the mainstream methods of virus detection, technical measures, and recommendations required in guidance toward commercial in-field applications. Toward this endeavor and beyond the pitfalls of current immunological and molecular techniques commonly applied to virus detection, several new approaches based on nanoparticles (NPs) have recently been developed. keywords: addition; amplification; antigen; assay; aunps; conjugates; detection; dna; fig; gold; hbv; hepatitis; hiv; human; infection; influenza; metal; molecular; nanoparticles; nucleic; probes; rna; sensitivity; silver; specific; surface; target; target dna; techniques; viral; virus; virus detection; viruses cache: cord-286719-1xjmlwqr.txt plain text: cord-286719-1xjmlwqr.txt item: #310 of 549 id: cord-287018-g4y5kjju author: Konstantinova, P title: Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA date: 2006-05-18 words: 7236 flesch: 49 summary: A Tat-inducible Pol II promoter expressing anti-HIV shRNA has been described for inhibition of HIV-1 gene expression in mammalian cells. Double-stranded RNA nef2 is a duplex of two separate, complementary sense and antisense nef sequences (8416-8695). keywords: cells; dsrna; expression; inhibition; lhrna; long; nef; nef1; nef2; pt7; rna; rnai; virus cache: cord-287018-g4y5kjju.txt plain text: cord-287018-g4y5kjju.txt item: #311 of 549 id: cord-287286-4l963z2q author: Green, Victoria A. title: Molecular mechanisms of viral infection and propagation: An overview of the second Advanced Summer School in Africa date: 2010-07-28 words: 7376 flesch: 35 summary: A detailed understanding of the molecular mechanisms governing virus infection and propagation is crucial to the development of antiviral strategies through identification of critical processes and drug targets. Research into the molecular basis of virus infection and propagation will enhance our understanding of virus-associated disease and inform new antiviral strategies and vaccine design. keywords: cancer; cell; development; dna; expression; gag; gene; group; hiv; host; hpv; human; import; infection; protein; school; vaccine; virus; viruses cache: cord-287286-4l963z2q.txt plain text: cord-287286-4l963z2q.txt item: #312 of 549 id: cord-287337-2ljbsia2 author: Ludwig, Christine title: Virus-like particles—universal molecular toolboxes date: 2008-01-04 words: 5073 flesch: 25 summary: Alternatively, GM-CSF was anchored in the VLP membrane by means of glycosylphosphatidylinositol (GPI) DNA vaccines encoding retrovirusbased virus-like particles induce efficient immune responses without adjuvant Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade C Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles Yeast-derived human immunodeficiency virus type 1 p55(gag) virus-like particles activate dendritic cells (DCs) and induce perforin expression in Gag-specific CD8(+) T cells by cross-presentation of DCs Virus-like particles exhibit potential as a pan-filovirus vaccine for both Ebola and Marburg viral infections Ebola virus-like particles produced in insect cells exhibit dendritic cell stimulating activity and induce neutralizing antibodies Immune responses against severe acute respiratory syndrome coronavirus induced by virus-like particles in mice Versatile RHDV viruslike particles: incorporation of antigens by genetic modification and chemical conjugation Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs Applications of influenza virosomes as a delivery system Structureactivity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation Influenza virosomes as an efficient system for adjuvanted vaccine delivery Clinical applications of virosomes in cancer immunotherapy Optimized Malariaantigens delivered by immunostimulating reconstituted influenza virosomes Enhancement of the immunogenicity of synthetic carbohydrates by conjugation to virosomes: a leishmaniasis vaccine candidate Targeting her-2/neu with antirat Neu virosomes for cancer therapy Immunogenicity and adverse effects of inactivated virosome versus alum-adsorbed hepatitis A vaccine: a randomized controlled trial Immunereconstituted influenza virosome containing CD40L gene enhances the immunological and protective activity of a carcinoembryonic antigen anticancer vaccine Virosome-mediated delivery of tumor antigen to plasmacytoid dendritic cells Intranasal immunization with mumps virus DNA vaccine delivered by influenza virosomes elicits mucosal and systemic immunity Cellular gene transfer mediated by influenza virosomes with encapsulated plasmid DNA Cellular delivery of siRNA mediated by fusion-active virosomes Changing viral tropism using immunoliposomes alters the stability of gene expression: implications for viral vector design Icosahedral virus particles as addressable nanoscale building blocks Self-assembly and cross-linking of bionanoparticles at liquid-liquid interfaces Virus-based toolkit for the directed synthesis of magnetic and semiconducting nanowires Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes We would like to thank the authors of the reviewed work for sharing their data and providing insight into their ingenious concepts and strategies. Indeed, wild-type BVs have been reported to induce strong innate immune responses upon intranasal inoculation capable of protecting mice from lethal challenge with influenza virus [31] . keywords: antigens; cells; dna; env; gag; hiv; particles; proteins; responses; vaccine; virosomes; virus; vlps cache: cord-287337-2ljbsia2.txt plain text: cord-287337-2ljbsia2.txt item: #313 of 549 id: cord-287348-00yaxpkp author: Martinez, Maria Jose Abad title: Antiviral Activities of Polysaccharides from Natural Sources date: 2005-12-31 words: 7010 flesch: 43 summary: Although relatively little work has been done on natural antivirals against plant viruses, several reports concerning antiviral activity against plant virus infection have been recorded; for example, yeast mannans with antiviral activity against the tobacco mosaic virus infection in tobacco plants [136] , and lichenan PS from Iceland moss which exhibited antiviral activity against the potato viruses [8] . For example, different natural polymeric carbohydrates inhibited rabies virus infection in chicken-embryo-related cells by interfering with the virus adsorption process [126] . keywords: activity; agents; alga; antiviral; cell; compounds; extracts; hiv; infections; marine; plant; replication; sulphate; virus; viruses; vitro cache: cord-287348-00yaxpkp.txt plain text: cord-287348-00yaxpkp.txt item: #314 of 549 id: cord-287754-dh6abx2t author: Akkouh, Ouafae title: Lectins with Anti-HIV Activity: A Review date: 2015-01-06 words: 6973 flesch: 42 summary: Mannose binding lectin triggers the complement pathway culminating in pathogen opsonization and phagocytosis. Microcystis viridis Solution structure of the monovalent lectin microvirin in complex with Man(α)(1-2)Man provides a basis for anti-HIV activity with low toxicity Mechanism by which the lectin actinohivin blocks HIV infection of target cells The high mannose-type glycan binding lectin actinohivin: Dimerization greatly improves anti-HIV activity A β-galactose-specific lectin isolated from the marine worm Chaetopterus variopedatus possesses anti-HIV-1 activity A new lectin from the sea worm Serpula vermicularis: Isolation, characterization and anti-HIV activity C-type lectin mermaid inhibits dendritic cell mediated HIV-1 transmission to CD4+T cells Mannose-binding geometry of pradimicin A Expression of mannose binding lectin in HIV-1-infected brain: keywords: activity; binding; carbohydrate; cd4; cells; cyanovirin; envelope; glycans; gp120; griffithsin; hiv; human; lectin; mannose; protein; type; virus cache: cord-287754-dh6abx2t.txt plain text: cord-287754-dh6abx2t.txt item: #315 of 549 id: cord-287853-cob7ur35 author: Sharma, Vaneet Kumar title: The expanding role of mass spectrometry in the field of vaccine development date: 2018-05-31 words: 3758 flesch: 12 summary: The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade Structural constraints determine the glycosylation of HIV-1 envelope trimers Ion mobility mass spectrometry for extracting spectra of N-glycans directly from incubation mixtures following glycan release: application to glycans from engineered glycoforms of intact, folded HIV gp120 MALDI-MS/MS with traveling wave ion mobility for the structural analysis of N-linked glycans Ion mobility mass spectrometry for ion recovery and clean-up of MS and MS/MS spectra obtained from low abundance viral samples Global Nglycan site occupancy of HIV-1 gp120 by metabolic engineering and high-resolution intact mass spectrometry Structural principles controlling HIV envelope glycosylation Global site-specific Nglycosylation analysis of HIV envelope glycoprotein Comprehensive characterization of reference standard lots of HIV-1 subtype C Gp120 proteins for clinical trials in Southern African regions Cell culture as a substrate for the production of influenza vaccines: memorandum from a WHO meeting Current and emerging cell culture manufacturing technologies for influenza vaccines Critical review of current and emerging quantification methods for the development of influenza vaccine candidates Influenza vaccine: the challenge of antigenic drift Confronting the next pandemic-workshop on lessons learned from potency testing of pandemic (H1N1) 2009 influenza vaccines and considerations for future potency tests Application of deglycosylation and electrophoresis to the quantification of influenza viral hemagglutinins facilitating the production of 2009 pandemic influenza (H1N1) vaccines at multiple manufacturing sites in China Quantification of influenza virus hemagglutinins in complex mixtures using isotope dilution tandem mass spectrometry Optimization of digestion parameters for protein quantification Simultaneous quantification of hemagglutinin and neuraminidase of influenza virus using isotope dilution mass spectrometry Quantification of viral proteins of the avian H7 subtype of influenza virus: an isotope dilution mass spectrometry method applicable for producing more rapid vaccines in the case of an influenza pandemic Development of influenza A (H7N9) candidate vaccine viruses with improved hemagglutinin antigen yield in eggs Quantification of immunoreactive viral influenza proteins by immunoaffinity capture and isotope-dilution liquid chromatography-tandem mass spectrometry Immunocapture isotope dilution mass spectrometry in response to a pandemic influenza threat Quantification of influenza neuraminidase activity by ultra-high performance liquid chromatography and isotope dilution mass spectrometry Label-free mass spectrometry-based quantification of hemagglutinin and neuraminidase in influenza virus preparations and vaccines Quantification of proteins by label-free LC-MSE Absolute quantification of proteins by LCMS E a virtue of parallel MS acquisition Selective and quantitative detection of influenza virus proteins in commercial vaccines using two-dimensional high-performance liquid chromatography and fluorescence detection Approach to the profiling and characterization of influenza vaccine constituents by the combined use of size-exclusion chromatography, gel electrophoresis and mass spectrometry Strain identification of commercial influenza vaccines by mass spectrometry Simultaneous quantification of the viral antigens hemagglutinin and neuraminidase in influenza vaccines by LC-MS E Fast and highly selective determination of hemagglutinin content in quadrivalent influenza vaccine by reversed-phase high-performance liquid chromatography method Advancing dengue vaccine development Site-specific characterization of envelope protein N-glycosylation on Sanofi Pasteur's tetravalent CYD dengue vaccine Absolute quantification of dengue virus serotype 4 chimera vaccine candidate in Vero cell culture by targeted mass spectrometry After Ebola in West Africaunpredictable risks, preventable epidemics Identification of N-glycans from Ebola virus glycoproteins by matrix-assisted laser desorption/ ionisation time-of-flight and negative ion electrospray tandem mass spectrometry Comparison of N-and O-linked glycosylation patterns of ebolavirus glycoproteins Development of a liquid chromatography high resolution mass spectrometry method for the quantitation of viral envelope glycoprotein in Ebola virus-like particle vaccine preparations Chikungunya virus: pathophysiology, mechanism, and modeling Development and application of a reversed-phase high-performance liquid chromatographic method for quantitation and characterization of a Chikungunya virus-like particle vaccine Characterization of Nglycosylation profiles from mammalian and insect cell derived chikungunya VLP Label-free quantitative mass spectrometry for analysis of protein antigens in a meningococcal group B outer membrane vesicle vaccine Physicochemical characterisation of glycoconjugate vaccines for prevention of meningococcal diseases Defined conjugation of glycans to the lysines of CRM 197 guided by their reactivity mapping Quantification by LC-MS E of outer membrane vesicle proteins of the Bexsero ® vaccine The dual role of lipids of the lipoproteins in Trumenba, a self-adjuvanting vaccine against meningococcal meningitis B disease Robust manufacturing and comprehensive characterization of recombinant hepatitis E viruslike particles in Hecolin ® Hepatitis E virus: a renewed hope with Hecolin Molecular and structural characterization of the L1 virus-like particles that are used as vaccine antigens in Cervarix™, the AS04-adjuvanted HPV-16 and-18 cervical cancer vaccine Viruslike particles in vaccine development Virus-like particle-based human vaccines: quality assessment based on structural and functional properties Status of vaccine research and development of vaccines for Nipah virus Proteomic composition of Nipah virus-like particles Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector Characterization of human enterovirus71 virus-like particles used for vaccine antigens Mass spectrometric characterization of the glycosylation pattern of HIV-gp120 expressed in CHO cells Glycan profiles of the 27 N-glycosylation sites of the HIV envelope protein CN54gp140 Comparative analysis of the glycosylation profiles of membrane-anchored HIV-1 envelope glycoprotein trimers and soluble gp140 Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding Haemagglutinin quantification and identification of influenza A&B strains propagated in PER. 77 Label-free MS-based methods have also been reported for the simultaneous identification and quantification of HA and NA in influenza vaccine with samples analyzed by LC-MS E on a Waters Synapt G2 mass spectrometer. keywords: analysis; characterization; development; envelope; glycosylation; influenza; mass; quantification; spectrometry; vaccine; virus cache: cord-287853-cob7ur35.txt plain text: cord-287853-cob7ur35.txt item: #316 of 549 id: cord-287949-243xlmep author: Onovo, A. A. title: Using Supervised Machine Learning and Empirical Bayesian Kriging to reveal Correlates and Patterns of COVID-19 Disease outbreak in sub-Saharan Africa: Exploratory Data Analysis date: 2020-05-02 words: 4906 flesch: 47 summary: Our study indicates, the doubling time in new coronavirus cases was 3 days. The trend in new coronavirus cases appears to be doubling in South Africa at every time increment compared to the other countries demonstrating an exponential trend. keywords: cases; coronavirus; countries; covid-19; data; disease; license; preprint; ssa cache: cord-287949-243xlmep.txt plain text: cord-287949-243xlmep.txt item: #317 of 549 id: cord-288440-w7g2agaf author: Jia, Rui title: The C-Terminal Sequence of IFITM1 Regulates Its Anti-HIV-1 Activity date: 2015-03-04 words: 4924 flesch: 47 summary: The virus stocks were named HIV-1 NL4-3 /BlaM-Vpr that has HIV-1 envelope protein, and NLENY1/VSV-G/BlaM-Vpr that has the VSV-G protein as the envelope, respectively. Mouse IFITM1 diminishes HIV-1 entry IFITM1 orthologs from different species are highly conserved, except for mouse and rat IFITM1 that have shortened C-termini (Fig. 4A ). keywords: bh10; cells; env; fig; human; ifitm1; nl4; protein; virus cache: cord-288440-w7g2agaf.txt plain text: cord-288440-w7g2agaf.txt item: #318 of 549 id: cord-288982-63ddlh20 author: Peeling, Rosanna W. title: Diagnostics in a digital age: an opportunity to strengthen health systems and improve health outcomes date: 2015-11-09 words: 4391 flesch: 38 summary: The simplest POC diagnostic tests that are widely used today are rapid diagnostics tests (RDTs) in a lateral flow format. The use of these non-invasive specimens has made it possible to design HIV tests for self-testing or for home use. keywords: care; control; data; diagnostics; disease; elimination; health; hiv; quality; surveillance; testing; tests cache: cord-288982-63ddlh20.txt plain text: cord-288982-63ddlh20.txt item: #319 of 549 id: cord-289274-3g67f8sw author: Tosoni, Elena title: Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription date: 2015-10-15 words: 8094 flesch: 40 summary: In particular, a very specific band migrated with the same rate in all G4 oligonucleotide samples (arrow in Figure 1B) , thus suggesting that the same protein was able to bind all LTR G4 sequences considered. While viral proteins were well represented in the transfected extract, the EMSA determinations revealed no major difference and confirmed that cellular proteins must constitute the major players in LTR G4 binding ( Figure 1C) . keywords: activity; binding; cells; dna; figure; human; ltr; milan; ncl; nucleolin; promoter; protein; quadruplex; rna; sequence; structures cache: cord-289274-3g67f8sw.txt plain text: cord-289274-3g67f8sw.txt item: #320 of 549 id: cord-289443-46w52de3 author: Sironi, Manuela title: Evolutionary insights into host–pathogen interactions from mammalian sequence data date: 2015-03-18 words: 9373 flesch: 31 summary: PLoS Pathog MHC class I antigen presentation: learning from viral evasion strategies An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection A 175 million year history of T cell regulatory molecules reveals widespread selection, with adaptive evolution of disease alleles The intertransmembrane region of Kaposi's sarcoma-associated herpesvirus modulator of immune recognition 2 contributes to B7-2 downregulation The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site Hiding lipid presentation: viral interference with CD1d-restricted invariant natural killer T (iNKT) cell activation A threonine-based targeting signal in the human CD1d cytoplasmic tail controls its functional expression Evolutionary history of copynumber-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection One of the few studies of helminth-driven selective pressure in mammals that also integrates evolutionary analysis with epidemiological information Thrombosis as an intravascular effector of innate immunity Dual host-virus arms races shape an essential housekeeping protein An extremely interesting study extending the arms race scenario to a housekeeping protein, the transferrin receptor Evolutionary reconstructions of the transferrin receptor of caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs Escape from bacterial iron piracy through rapid evolution of transferrin Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes Niemann-Pick C1 (NPC1)/ NPC1-like1 chimeras define sequences critical for NPC1's function as a flovirus entry receptor Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1 Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection Inhibition of ebola virus infection: identification of Niemann-Pick C1 as the target by optimization of a chemical probe Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection Evolutionary analysis of the contact system indicates that kininogen evolved adaptively in mammals and in human populations Positive selection during the evolution of the blood coagulation factors in the context of their disease-causing mutations Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus Viral immune modulators perturb the human molecular network by common and unique strategies Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers PAML 4: phylogenetic analysis by maximum likelihood Accuracy and power of Bayes prediction of amino acid sites under positive selection Bayes empirical Bayes inference of amino acid sites under positive selection Detecting individual sites subject to episodic diversifying selection High sensitivity to aligner and high rate of false positives in the estimates of positive selection in the 12 Drosophila genomes Class of multiple sequence alignment algorithm affects genomic analysis Estimates of positive Darwinian selection are inflated by errors in sequencing, annotation, and alignment The effects of alignment error and alignment filtering on the sitewise detection of positive selection Effect of recombination on the accuracy of the likelihood method for detecting positive selection at amino acid sites Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level The effect of insertions, deletions, and alignment errors on the branch-site test of positive selection Multiple hypothesis testing to detect lineages under positive selection that affects only a few sites A random effects branchsite model for detecting episodic diversifying selection Modeling the site-specific variation of selection patterns along lineages Performance of standard and stochastic branch-site models for detecting positive selection among coding sequences Statistical properties of the branch-site test of positive selection Towards a systems understanding of MHC class I and MHC class II antigen presentation CD1 antigen presentation: how it works The authors declare no competing interests. In this case the branch of the phylogeny leading to these species may show significant evidence of positive selection . keywords: analysis; binding; cell; evolution; example; genes; host; human; infection; mammalian; mammals; pathogen; protein; receptor; red; selection; sites; species; virus cache: cord-289443-46w52de3.txt plain text: cord-289443-46w52de3.txt item: #321 of 549 id: cord-291063-de7v4e5s author: Moens, Ugo title: Silencing Viral MicroRNA as a Novel Antiviral Therapy? date: 2009-05-28 words: 9133 flesch: 42 summary: Hence, neutralizing the action of viral miRNAs expression by complementary single-stranded oligonucleotides or so-called anti-miRNAs may represent a strategy to combat viral infections and viral-induced pathogenesis. Human polyomaviruses: molecular mechanisms for transformation and their association with cancers The role of polyomaviruses in human disease Identification of a third human polyomavirus Identification of a novel polyomavirus from patients with acute respiratory tract infections Clonal integration of a polyomavirus in human Merkel cell carcinoma Molecular biology of BK virus and clinical aspects of BK virus renal infection SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells Evolutionarily conserved function of a viral microRNA Merkel cell polyomavirus encodes a microRNA with the ability to autoregulate viral gene expression MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs Human cytomegalovirus expresses novel microRNAs during productive viral infection Identification and function of human cytomegalovirus microRNAs Identification of virus-encoded microRNAs A microRNA polycistron as a potential human oncogene Hepadnaviruses HBV-encoded microRNA candidate and its target 25 years of HIV-1 research-progress and perspectives RNA silencing and HIV: a hypothesis for the etiology of the severe combined immunodeficiency induced by the virus HIV-1 nef suppression by virally encoded microRNA Human papillomavirus genotype 31 does not express detectable microRNA levels during latent or productive virus replication Adenoviruses Structure, function and evolution of adenovirus virus-associated RNAs Suppression of RNA interference by adenovirus virus-associated RNA Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production Sequence-specific interference by small RNAs derived from adenovirus VAI RNA The family Herpesviridae: a brief introduction Identification of microRNAs of the herpesvirus family Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor Prediction and identification of herpes simplex virus 1-encoded microRNAs Novel less-abundant viral miRNAs encoded by herpes simplex virus 2 latencyassociated transcript and their roles in regulating ICP34.5 and ICP0 mRNAs keywords: amos; cells; ebv; expression; gene; host; hsv-1; human; infection; k12; micrornas; mir; mirna; protein; replication; silencing; target; virus; viruses cache: cord-291063-de7v4e5s.txt plain text: cord-291063-de7v4e5s.txt item: #322 of 549 id: cord-291534-c6cjxq07 author: Gwyer Findlay, Emily title: Cationic Host Defence Peptides: Potential as Antiviral Therapeutics date: 2013-05-07 words: 8792 flesch: 33 summary: A/PR/8/34 hemagglutinin (H1 subtype) alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s) Role of protein kinase C betaII in influenza virus entry via late endosomes Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D Mechanism of adenovirus neutralization by human alpha-defensins Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy Human alpha-defensins block papillomavirus infection Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro Adenovirus-directed ocular innate immunity: the role of conjunctival defensin-like chemokines (IP-10, I-TAC) and phagocytic human defensin-alpha Critical determinants of human alpha-defensin 5 activity against nonenveloped viruses Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection Enhanced expression of murine beta-defensins (MBD-1, -2,-3, and -4) in upper and lower airway mucosa of influenza virus infected mice Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivo Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappaB-mediated innate antiviral response against human respiratory syncytial virus Oral human beta-defensin 2 in HIV-infected subjects with long-term use of antiretroviral therapy Human betadefensins suppress human immunodeficiency virus infection: potential role in mucosal protection Cutting edge: human beta defensin 3-a novel antagonist of the HIV-1 coreceptor CXCR4 beta-Defensin genomic copy number is associated with HIV load and immune reconstitution in subsaharan Africans Increased levels of human betadefensins mRNA in sexually HIV-1 exposed but uninfected individuals Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity Recombinant mouse beta-defensin 2 inhibits infection by influenza A virus by blocking its entry Antiviral activity of recombinant mouse beta-defensin 3 against influenza A virus in vitro and in vivo Cytokine (tumor necrosis factor, IL-6, and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages Antiviral activity of human beta-defensin 3 against vaccinia virus Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins Retrocyclin: a primate peptide that protects cells from infection by T-and M-tropic strains of HIV-1 Evaluation of a theta-defensin in a murine model of herpes simplex virus type 1 keratitis. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cellinduced T cell polarization Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium Direct inactivation of viruses by human granulocyte defensins Human alpha-and beta-defensins block multiple steps in herpes simplex virus infection Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry Multivalent binding of carbohydrates by the human alpha-defensin, HD5 Defensins inhibit HIV replication in vitro Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor Retraction of an interpretation Alpha-defensins in the prevention of HIV transmission among breastfed infants Multifaceted mechanisms of HIV-1 entry inhibition by human alpha-defensin Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity Alphadefensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4 Alpha-defensins inhibit HIV infection of macrophages through upregulation of CC-chemokines Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection Defensins induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment Antibacterial peptides in bronchoalveolar lavage fluid Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis Production of beta-defensins by human airway epithelia Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins The antigenic structure of the influenza virus keywords: activity; alpha; beta; cells; defensins; effects; expression; hiv; hnp1; host; human; infection; ll-37; peptide; potential; properties; virus cache: cord-291534-c6cjxq07.txt plain text: cord-291534-c6cjxq07.txt item: #323 of 549 id: cord-291577-nf80kih2 author: Baluku, Joseph Baruch title: HIV and SARS‐CoV‐2 co‐infection: A case report from Uganda date: 2020-05-21 words: 1728 flesch: 50 summary: Coronavirus disease (COVID-19): Situation report 108 Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China HIV Infection and AIDS in Sub-Saharan Africa: Current Status, Challenges and Opportunities Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city COVID-19 in patients with HIV: clinical case series Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis Computed Tomography Imaging of an HIV-infected Patient with Coronavirus Disease 2019 (COVID-19) HIV/SARS-CoV-2 co-infected patients in Istanbul, Turkey Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography Frequency and Distribution of Chest Radiographic Findings in COVID-19 Positive Patients Chest radiographs in acute pulmonary embolism. The optimal ART among HIV patients with COVID -19 is not established yet. keywords: case; cov-2; hiv; patients; sars cache: cord-291577-nf80kih2.txt plain text: cord-291577-nf80kih2.txt item: #324 of 549 id: cord-292286-ygomb3oi author: Zakaryan, Hovakim title: Flavonoids: promising natural compounds against viral infections date: 2017-05-25 words: 6103 flesch: 31 summary: Apigenin inhibits enterovirus 71 replication through suppressing viral IRES activity and modulating cellular JNK pathway Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro Phenolic acids act as signaling molecules in plant-microbe symbioses Identification and evaluation of antihepatitis C virus phytochemicals from Eclipta alba Computational docking study of p7 Ion channel from HCV genotype 3 and genotype 4 and its interaction with natural compounds A flavonoid, luteolin, cripples HIV-1 by abrogation of tat function The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer Evaluation of the antiviral activity of kaempferol and its glycosides against human cytomegalovirus Metabolomics view on gut microbiome modulation by polyphenol-rich foods Baicalin, a metabolite of baicalein with antiviral activity against dengue virus Combined effects of flavonoids and acyclovir against herpesviruses in cell cultures Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyland sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions Anti-chikungunya activity ofl uteolin and apigenin rich fraction from Cynodon dactylon Neuroprotective effects of chrysin: from chemistry to medicine Differential inhibition of HIV-reverse transcriptase and various DNA and RNA polymerases by somecatechin derivatives Differential inhibitory effects of some catechin derivatives on the activities of human immunodeficiency virus reverse transcriptase and cellular deoxyribonucleic and ribonucleic acid polymerases Inhibition of the infectivity of influenza virus by tea polyphenols Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial silico study on anti-Chikungunya virus activity of hesperetin Anti-Sindbis activity of flavanones hesperetin and naringenin Anti-HIV-1 activity of flavonoid myricetin on HIV-1 infection in a dual-chamber in vitro model Plant derived compounds having activity against P388 and L1210 leukemia cells Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays Genistein inhibits the replication of avian leucosis virus subgroup J in DF-1 cells Apigenin restricts FMDV infection and inhibits viral IRES driven translational activity Anti-inflammatory effect of quercetin-loaded microemulsion in the airways allergic inflammatory model in mice Drugs of natural origin Genistein as antiviral drug against HIV ion channel Absorption and metabolism of polyphenols in the gut and impact on health Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus Comparison of the antiviral activity of flavonoids Antiviral activity of flavonoids against murine norovirus and feline calicivirus Computational approach towards exploring potential anti-Chikungunya activity of selectedflavonoids The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin Interestingly, naringin, the glycoside form of naringenin did not have anti-Sindbis virus activity, indicating that the rutinose moiety of this flavanone blocks its antiviral effect. keywords: activity; anti; cells; compounds; effect; egcg; flavonoids; infection; influenza; inhibition; inhibits; kaempferol; quercetin; replication; studies; tea; virus cache: cord-292286-ygomb3oi.txt plain text: cord-292286-ygomb3oi.txt item: #325 of 549 id: cord-292521-tpb12dkq author: Howard, John title: Widely Disseminated Cryptococcosis Manifesting in a Previously Undiagnosed Human Immunodeficiency Virus (HIV)-Positive 18-Year-Old date: 2020-10-12 words: 2307 flesch: 44 summary: This report describes an unusual opportunistic infection in a young patient with no prior clinical evidence of HIV infection. Only during autopsy was the disseminated fungal infection discovered, leading to suspicion of HIV infection. keywords: autopsy; cd4; hiv; infection; patient; symptoms cache: cord-292521-tpb12dkq.txt plain text: cord-292521-tpb12dkq.txt item: #326 of 549 id: cord-292546-un0blb3w author: Dandachi, Dima title: Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients with HIV and Coronavirus Disease-19 date: 2020-09-09 words: 3441 flesch: 50 summary: Infection Clinical features and outcomes of HIV patients with coronavirus disease 2019 Outcomes among HIV-positive patients hospitalized with COVID-19 Covid-19 and People with HIV Infection: Outcomes for Hospitalized Patients Clinical characteristics, comorbidities and outcomes among persons with HIV hospitalized with coronavirus disease Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort. Ongoing research aims to determine the impact of structural racism in COVID-19 outcomes. keywords: covid-19; hiv; outcomes; patients cache: cord-292546-un0blb3w.txt plain text: cord-292546-un0blb3w.txt item: #327 of 549 id: cord-292740-b4cdj96q author: Wahid, Braira title: Immunotherapeutic strategies for sexually transmitted viral infections: HIV, HSV and HPV date: 2016-08-03 words: 10116 flesch: 27 summary: A study demonstrated that virus specific T cells produced in response to antigen presenting cells along with unmanipulated T cells are helpful in treatment of viral infections such as cytomegalovirus, HIV, Ebola virus and adenoviruses [59, 60] . Modification of human HSPCs (hematopoietic stem progenitor cells) with an HIV-specific CD4f CAR can differentiate HIV specific T cells and cells of other lineages that are able to decrease viral loads in vivo. keywords: antibodies; antibody; cancer; cd4; cells; diseases; herpes; hiv; hpv; human; immune; infected; infection; monoclonal; patients; specific; study; therapy; vaccine; virus cache: cord-292740-b4cdj96q.txt plain text: cord-292740-b4cdj96q.txt item: #328 of 549 id: cord-292830-gcfx1095 author: Ianevski, Aleksandr title: Novel activities of safe-in-human broad-spectrum antiviral agents date: 2018-04-23 words: 5527 flesch: 38 summary: 300 μL PBS was added to each well and the plate was analyzed in the Trophos plate runner HD (Trophos, Roche Group) to count the number of virus infected cells per well, by identifying all individual cells expressing the far-red fluorescent protein Katushka (Islam et al., 2018) . Combating emerging viral threats Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects Statins in HIV-infected patients: potential beneficial effects and clinical use Use of FDA approved therapeutics with hNTCP metabolic inhibitory properties to impair the HDV lifecycle Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Clinical Trial Resources Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study Curious (old and new) antiviral nucleoside analogues with intriguing therapeutic potential Approved antiviral drugs over the past 50 years Alisporivir inhibits MERS-and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model The future of antivirals: broad-spectrum inhibitors Chikungunya disease and chloroquine treatment Chloroquine, an endocytosis blocking agent, inhibits Zika virus infection in different cell models Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study Zika virus infection with prolonged maternal viremia and fetal brain abnormalities Infectious disease. keywords: agents; antiviral; cells; compounds; diseases; drugs; et al; fig; human; infection; inhibit; target; virus; viruses; zikv cache: cord-292830-gcfx1095.txt plain text: cord-292830-gcfx1095.txt item: #329 of 549 id: cord-293379-c4qdmkw5 author: Weiss, Robin A title: HIV and AIDS: looking ahead date: 2003 words: 3594 flesch: 42 summary: structural and antigenic relatedness with equine infectious anaemia virus Nucleotide sequence of the AIDS virus Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS HIV and AIDS: 20 years of science HIV-1 pathogenesis 20 years of therapy for HIV-1 infection Slim disease: a new disease in Uganda and its association with HTLV-III infection Multicentre study on factors determining differences in rate of spread of HIV in sub-Saharan Africa: methods and prevalence of HIV infection Let it be sexual: how health care transmission of AIDS in Africa was ignored The injection century: massive unsterile injections and the emergence of human pathogens Expert group stresses that unsafe sex is primary mode of HIV transmission in Epidemiology: sexual transmission of HIV in Africa Accomplishments in HIV prevention science: implications for stemming the epidemic Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis Male circumcision: current epidemiological and field evidence HIV-1 transmission, acute infection, and the quest for strategies to prevent infection Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton Multiply infected spleen cells in HIV patients Cellular inhibitors with Fv1-like activity restrict human and simian immunodeficiency virus tropism Restriction of multiple divergent retroviruses by Lv1 and Ref1 Human immunodeficiency virus type 2 Cultivation of visna virus in tissue culture Lentivirus tropism and pathogenesis Are RNA viruses adapting or merely changing? Evolutionary and immunological implications of contemporary HIV-1 variation Modelling viral and immune system dynamics Timing the ancestor of the HIV-1 pandemic strains Tracing the origin and history of the HIV-2 epidemic AIDS as a zoonosis: scientific and public health implications Human immunodeficiency virus type 1 intergroup (M/O) recombination in Cameroon Nonreciprocal packaging of human immunodeficiency virus type 1 and type 2 RNA: a possible role for the p2 domain of Gag in RNA encapsidation Antibody neutralization and escape by HIV-1 Rapid evolution of the neutralizing antibody response to HIV type 1 infection Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS Global survey of genetic variation in CCR5, RANTES, and MIP-1α: impact on the epidemiology of the HIV-1 pandemic 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial Smallpox vaccination and patients with human immunodeficiency virus infection or acquired immunodeficiency syndrome Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) disease AIDS-related malignancies Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis Interactions between herpes simplex virus type 2 and human immunodeficiency virus type 1 infection in African women: opportunities for intervention Infection with GB virus C and reduced mortality among HIV-infected patients Effect of coinfection with GB virus C on survival among patients with HIV infection HIV-1 suppression during acute scrub-typhus infection Decrease in human immunodeficiency virus type 1 load during acute dengue fever Catastrophic ape decline in western equatorial Africa Vaccine for AIDS and Ebola virus infection HIV and AIDS in relation to other pandemics There is much concern over the risk of reintroducing smallpox vaccination to people infected with HIV 47 because disseminated vaccinosis may ensue, as has been reported in an HIV-positive military recruit 48 . HIV HIV 6 yea 6 yea 10% 10% C C J G D Figure 2 keywords: africa; aids; hiv; human; infection; science; transmission; virus; years cache: cord-293379-c4qdmkw5.txt plain text: cord-293379-c4qdmkw5.txt item: #330 of 549 id: cord-293653-u2qrxq6t author: Watashi, Koichi title: Cyclophilin and Viruses: Cyclophilin as a Cofactor for Viral Infection and Possible Anti-Viral Target date: 2007-02-05 words: 4900 flesch: 34 summary: and they can act as potent chemoattractants for neutrophils (Sherry et al. 1992) , eosinophils (Xu et al. 1992) , and T cells (Allain et al. 2002) . From the results, the hypothesis was proposed by Luban et al. keywords: binding; cells; csa; cyclophilin; cypa; cypb; et al; hcv; human; protein; replication; virus cache: cord-293653-u2qrxq6t.txt plain text: cord-293653-u2qrxq6t.txt item: #331 of 549 id: cord-293857-o8rlqsq5 author: Ghosh, Arun K. title: Organic Carbamates in Drug Design and Medicinal Chemistry date: 2015-01-07 words: 18292 flesch: 35 summary: Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys ] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: I. Design, synthesis, enzymatic conversion to gabapentin, and transport by intestinal solute transporters Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin Hydrolysis of capecitabine to 5′-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue Rational development of capecitabine Capecitabine: a review Profound and sustained inhibition of platelet aggregation by Fradafiban, a nonpeptide platelet glycoprotein IIb/IIIa antagonist, and its orally active prodrug, Lefradafiban, in men Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance Enhancing protein backbone bindinga fruitful concept for combating drug-resistant HIV Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands Anti-HIV protease inhibitor Darunavir Inhibitors of HIV-1 protease containing the novel and potent (R)-(hydroxyethyl)sulfonamide isostere Design and synthesis of Amprenavir, a novel HIV protease inhibitor The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors Nonpeptidal P2 ligands for HIV protease inhibitors: structure-based design, synthesis, and biological evaluation Structure-based design of non-peptide HIV protease inhibitors Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114 A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site Potent inhibition of HIV-1 replication by novel nonpeptidyl small molecule inhibitors of protease dimerization Design of HIV-1 protease inhibitors active on multidrug-resistant virus Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drugresistant HIV Darunavir, a new PI with dual mechanism: from a novel drug design concept to new hope against drug-resistant HIV Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114) Synthesis and optical resolution of high affinity P2-ligands for HIV-1 protease inhibitors A novel bistetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385 Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration The discovery of β-secretase and development toward a clinical inhibitor for AD: an exciting academic collaboration Design of potent inhibitors for human brain memapsin 2 (βsecretase) A wide variety of human rhinovirus 3C (HRV 3C) protease inhibitors were developed by the incorporation of α,βunsaturated carbonyl moieties as warheads. keywords: acid; activity; amide; amines; bond; carbamate; carbonates; design; development; drug; enzyme; figure; group; hcv; hiv; human; hydrogen; hydrolysis; inhibitors; method; novel; prodrugs; protease; protease inhibitors; reaction; rearrangement; scheme; secretase; serine; structure; synthesis; table; treatment; virus cache: cord-293857-o8rlqsq5.txt plain text: cord-293857-o8rlqsq5.txt item: #332 of 549 id: cord-294366-swwz4kzd author: Bramwell, Vincent W. title: The rational design of vaccines date: 2005-11-15 words: 4882 flesch: 27 summary: In this complex but increasingly focussed environment of vaccine development, are there opportunities for new solutions for vaccine design? This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. keywords: antibody; antigens; cancer; cells; design; development; diseases; hiv; infection; responses; tuberculosis; vaccine; virus cache: cord-294366-swwz4kzd.txt plain text: cord-294366-swwz4kzd.txt item: #333 of 549 id: cord-295062-8rl4kswe author: Marsh, Mark title: Virus Entry: Open Sesame date: 2006-02-24 words: 8517 flesch: 34 summary: Microbiol Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding Role of lipid rafts in virus replication Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms Caveolar endocytosis of simian virus 40 reveals a new two-step vesicular-transport pathway to the ER Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae Caveolinstabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic Genome-wide analysis of human kinases in clathrin-and caveolae/raft-mediated endocytosis Echovirus 1 endocytosis into caveosomes requires lipid rafts, dynamin II, and signaling events Viral entry, lipid rafts and caveosomes The neutral glycosphingolipid globotriaosylceramide promotes fusion mediated by a CD4-dependent CXCR4-utilizing HIV type 1 envelope glycoprotein Adaptable adaptors for coated vesicles Picornavirus-receptor interactions Assembly of endocytic machinery around individual influenza viruses during viral entry Viral RNA replication in association with cellular membranes Lv2, a novel postentry restriction, is mediated by both capsid and envelope Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein Interaction with decay-accelerating factor facilitates coxsackievirus B infection of polarized epithelial cells Influenza virus can enter and infect cells in the absence of clathrin-mediated endocytosis Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin How viruses enter animal cells Ganglioside-dependent cell attachment and endocytosis of murine polyomavirus-like particles Vaccinia virus motility Major histocompatibility complex class I molecules mediate association of SV40 with caveolae High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding The structure of simian virus 40 refined at 3.1 A resolution Virus maturation: dynamics and mechanism of a stabilizing structural transition that leads to infectivity Structural basis of nonenveloped virus cell entry The cytoplasmic body component TRIM5al-pha restricts HIV-1 infection in Old World monkeys Assembly and trafficking of caveolar domains in the cell: caveolae as stable, cargo-triggered, vesicular transporters Cellular RNA-editing enzymes can be packaged into virus particles and can introduce mutations in the viral genome during the reverse-transcription event that occurs shortly after virus entry. keywords: cell; clathrin; endocytosis; entry; et al; infection; membrane; particles; pathways; penetration; proteins; receptors; surface; virus; viruses cache: cord-295062-8rl4kswe.txt plain text: cord-295062-8rl4kswe.txt item: #334 of 549 id: cord-295099-ghc85pf5 author: Sun, Zehua title: Brief introduction of current technologies in isolation of broadly neutralizing HIV-1 antibodies date: 2018-01-02 words: 7476 flesch: 22 summary: The gp120 or gp41 proteins are not ideal probes, because they are reactive with many HIV-1 antibodies, including non-neutralizing but strong binding antibodies (Wu et al., 2010; Wu et al., 2015; Zhou et al., 2015) . This observation suggests that extraordinary variation in antibody immunity may only occur within a few antibody lineages − or even a single lineage (Wu et al., 2015) . keywords: antibodies; antibody; antigen; binding; cell; chain; display; domain; et al; hiv-1; human; hybridoma; monoclonal; neutralization; phage; potent; single; virus cache: cord-295099-ghc85pf5.txt plain text: cord-295099-ghc85pf5.txt item: #335 of 549 id: cord-295290-hs5ntlok author: Atlan, H. title: Mechanisms of autoimmunity and AIDS: prospects for therapeutic intervention date: 1994-12-31 words: 9839 flesch: 27 summary: The interactions between Mycobacterium tuberculosis and the immune system leading to the development of autoimmune disease HIV infection: facts and hypotheses Approaches to AIDS therapy Association of human immunodeficiency virus infection and autoimmune phenomena Antibodies to CD4 in individuals infected with human immunodeficiency virus type 1 Harming and protecting responses to HIV T cells can present antigens such as HIV gp120 targeted to their own surface molecules Determinant spreading and the dynamics of the autoimmune T-cell repertoire Therapeutic vaccination against adjuvant arthritis using autoimmune T-lymphocytes treated with hydrostatic pressure Anti-idiotypic network induced by T-cell vaccination against experimental autoimmune encephalomyelitis Control of experimental autoinimune encephalomyelitis by T cells responding to activated T cells Influence of host genotype on progression to AIDS among HIVinfected men Human T-cell lymphotropic virus 111s glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack AIDS research turned upside down Immunological consequences of HIV infection: advantage of being low responder casts doubts on vaccine development New insights on the mechanisms of CD4+ lymphocytes depletion in AIDS AIDS virus infection and autoimmunity : a perspective of the clinical, immunological, and molecular origins of the autoallergic pathologies associated with HIV disease Graft-vs-host reaction limited to a class II MHC difference results in a selective deficiency in L3T4+ but not in Lyt-2+ T helper cell function T-cell receptor peptide therapy triggers autoregulation of experimental encephalomyelitis Identification of HIV-l envelope glycoprotein in the serum of AIDS and ARC patients Autoantibodies against liver cell membrane detected by enzymelinked immunosorbent assay in acute and chronic liver disease Protection from experimental allergic encephalomyelitis conferred by a monoclonal antibody directed against a shared idiotype on rat T-cell receptors specific for myelin basic protein The immunopathogenesis of human immunodeficiency virus infection V-region connectivity in T cell repertoires HIV-specific cytotoxic T lymphocytes IgM, IgG and IgA rheumatoid factors and circulating immune complexes in patients with AIDS and AIDS-related complex with serological abnormalities Major histocompatibility gene products and human immunodeficiency virus infection Prevention of experimental autoimmune thyroiditis through the antiidiotypic network A lectin-binding soluble factor released by CD8+CD57+ lymphocytes from AIDS patients inhibits T-cell cytotoxicity Prospects for the control of AIDS by immunizing seropositive individuals A strategy for prophylactic vaccination against HIV A novel HIV vaccine strategy Human immunodeficiency virus infection and autoimmune phenomena Shedding and interspecies type seroreactivity of the envelope glycopolypeptide gp120 of the human immunodeficiency virus The reservoir for HIV-l in human peripheral blood is a T cell that maintains expression of CD4 Acquired immune-deficiency syndrome (AIDS) : a consequence of allogeneic Ia-antigen recognition AIDS: an autoimmune pathologic model for the destruction of a subset of helper T lymphocytes T helper cell immune dysfunction in asymptomatic, HIV-l seropositive individuals: the role of THl-TH2 cross-regulation Analysis of host-virus interactions in AIDS with anti-gpl20 T-cell clones : effect of HIV sequence variation and a mechanism for CD4+ cell depletion Determinants of HIV disease progression : six-year longitudinal study in the Edinburgh haemophilia/HIV cohorts Unexplained opportunistic infections and CD4+ T-lymphocytopenia without HIV infection. Schematically, effector T cells specific for self-antigens exist normally, but their activity is modulated and prevented by networks of regulatory T cells. keywords: aids; antigen; autoimmune; autoimmunity; cd4; cells; cohen; disease; effector; et al; gp120; hiv; infection; network; self; vaccination cache: cord-295290-hs5ntlok.txt plain text: cord-295290-hs5ntlok.txt item: #336 of 549 id: cord-295494-wal0gtrs author: Limeres Posse, Jacobo title: Infection Transmission by Saliva and the Paradoxical Protective Role of Saliva date: 2017-07-31 words: 5309 flesch: 29 summary: The first Harry F. Dowling lecture Kissing as an evolutionary adaptation to protect against human cytomegalovirus-like teratogenesis Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay Saliva and wound healing Antiviral activities in human saliva The functions of human saliva: a review sponsored by the world workshop on oral medicine VI Host-pathogen co-evolution and glycan interactions Salivary mucin as related to oral Streptococcus mutans in elderly people Mucins suppress virulence traits of Candida albicans The role of crude human saliva and purified salivary MUC5B and MUC7 mucins in the inhibition of human immunodeficiency virus type 1 in an inhibition assay Antiviral effect of human saliva against hantavirus Sialic acid content in human saliva and anti-influenza activity against human and avian influenza viruses e.g., H5N1 influenza virus are particularly susceptible to human saliva, which may play a role in its infectivity and transmissibility. keywords: albicans; candida; candidiasis; hiv; human; immunity; infection; kissing; proteins; role; saliva; salivary; transmission; virus cache: cord-295494-wal0gtrs.txt plain text: cord-295494-wal0gtrs.txt item: #337 of 549 id: cord-296309-i1mpov7k author: Houldcroft, Charlotte J. title: Clinical and biological insights from viral genome sequencing date: 2017-01-16 words: 9059 flesch: 23 summary: The concentration of virus particles (see the Zika virus example above 72 ), depletion of host material and/or sequencing to high read depth can increase the amount of virus sequence, but all of these methods add to the cost. This is particularly relevant for rapid responses to emerging threats, such as Zika virus 81 . keywords: dna; drug; enrichment; example; genome; hiv; methods; pcr; resistance; rna; sequence; sequencing; target; variants; virus; viruses; wgs; zika cache: cord-296309-i1mpov7k.txt plain text: cord-296309-i1mpov7k.txt item: #338 of 549 id: cord-297125-la20vi9j author: Brower, Jennifer L. title: The Threat and Response to Infectious Diseases (Revised) date: 2016-08-01 words: 12338 flesch: 40 summary: Slides: generics to push statin revenues down by $7B. Cardiovascular Business Fidaxomicin versus vancomycin for Clostridium Difficile infection Industrial production of β-lactam antibiotics Evidence linking arctic amplification to extreme weather in mid-latitudes Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness The ecology and evolutionary history of an emergent disease: hantavirus pulmonary syndrome Impacts of biodiversity on the emergence and transmission of infectious diseases Increased avian diversity is associated with lower incidence of human West Nile infection: observation of the dilution effect Avian diversity and West Nile virus: testing associations between biodiversity and infectious disease risk Mapping of poverty and likely zoonoses hotspots Healthy animals, healthy people: zoonosis risk from animal contact in pet shops, a systematic review of the literature Emerging infectious diseases of wildlife-threats to biodiversity Tuberculosis in humans and animals: are we a threat to each other? CDC (2015) H5 viruses in the United States Human food safety not likely threatened by costly Avian Flu Economic impact of Avian Influenza Infectious disease, endangerment, and extinction Effects of environmental change on emerging parasitic diseases Patterns of gastrointestinal bacterial exchange between chimpanzees and humans involved in research and tourism in western Uganda Promoting childhood immunizations Measles activity in Canada Working Group on Measles Elimination (2004) According to the Centers for Disease Control and Prevention (CDC), emerging infectious diseases are those whose incidence in humans has increased in the past two decades or threatens to increase in the near future keywords: antibiotic; bacteria; cases; diseases; drug; global; health; human; infections; medical; mortality; new; pathogens; people; public; resistance; response; states; threat; treatment; united; united states; use; vaccine; virus; water; world cache: cord-297125-la20vi9j.txt plain text: cord-297125-la20vi9j.txt item: #339 of 549 id: cord-297135-mg2qs3b6 author: Smith, Kumi title: A harm reduction paradox: Comparing China's policies on needle and syringe exchange and methadone maintenance date: 2012-07-31 words: 5307 flesch: 33 summary: Findings Early consensus between public security and public health sectors regarding methadone's dual use in HIV prevention as well as method of drug control created broad institutional support for MMT programmes amongst policy makers. Advocates assert that MMT programmes also indirectly reduce drug-related criminal activity and improve social and employment stability (IHRD, 2008; Ministry of Health, 2008) . keywords: china; drug; harm; hiv; injection; mmt; needle; nsep; policy; prevention; programmes; reduction cache: cord-297135-mg2qs3b6.txt plain text: cord-297135-mg2qs3b6.txt item: #340 of 549 id: cord-297257-lzybfwc2 author: Savarino, Andrea title: Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS date: 2015-06-18 words: 4916 flesch: 34 summary: Not surprisingly for a drug effective against an autoimmune disease such as rheumatoid arthritis, auranofin may as well be beneficial in terms of reduction of cell activation. The Multicenter AIDS Cohort Study Group Increased numbers of primed activated CD8+ CD38+ CD45RO+ T cells predict the decline of CD4+ T cells in HIV-1-infected patients T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy Immune activation and HIV persistence: considerations for novel therapeutic interventions Effects of chloroquine on viral infections: an old drug against today's diseases? keywords: activation; aids; cells; chloroquine; effects; hiv; hydroxychloroquine; infection; viral; virus cache: cord-297257-lzybfwc2.txt plain text: cord-297257-lzybfwc2.txt item: #341 of 549 id: cord-297303-cpajrgba author: Nguyen, Annie L. title: Leaning on Community-Based Participatory Research to Respond During COVID-19 date: 2020-05-14 words: 1177 flesch: 43 summary: key: cord-297303-cpajrgba authors: Nguyen, Annie L.; Christensen, Christopher; Taylor, Jeff; Brown, Brandon title: Leaning on Community-Based Participatory Research to Respond During COVID-19 date: 2020-05-14 journal: AIDS Behav DOI: 10.1007/s10461-020-02922-1 sha: doc_id: 297303 cord_uid: cpajrgba nan We partnered with the HIV + Aging Research Project, a community-based, nonprofit organization founded as a collaboration between local HIV clinicians and people living with HIV, to study the clinical and psychosocial aspects of aging among long-term HIV survivors. The speed at which we were able to respond was due to several factors: (1) our team's existing networks of experts in HIV and aging, (2) an established steering committee with members who are familiar with reviewing and providing feedback about research, (3) relationships that have cultivated trust between academics and community members over time, and (4) a responsive institutional review board. keywords: community; covid-19; hiv; research cache: cord-297303-cpajrgba.txt plain text: cord-297303-cpajrgba.txt item: #342 of 549 id: cord-297530-7zbvgvk8 author: Kühnert, Denise title: Phylogenetic and epidemic modeling of rapidly evolving infectious diseases date: 2011-08-31 words: 12828 flesch: 33 summary: Recent population genetic models account for population dynamics e.g., in order to enhance the understanding of allele fixation processes and the importance of demographic stochasticity (Parsons and Quince, 2007; Champagnat and Lambert, 2007; Non-parametric coalescent methods provide greater flexibility by estimating the population size as a function of time directly from the sequence data and can be used for data exploration to guide the choice of parametric population models for further analysis. keywords: analysis; bayesian; coalescent; data; dynamics; epidemic; et al; evolution; history; host; inference; influenza; methods; model; population; rate; sampling; size; time; transmission; tree; virus cache: cord-297530-7zbvgvk8.txt plain text: cord-297530-7zbvgvk8.txt item: #343 of 549 id: cord-297612-swc2pitd author: Nosyk, Bohdan title: Contact tracing for COVID-19: An opportunity to reduce health disparities and End the HIV/AIDS Epidemic in the US date: 2020-04-27 words: 1639 flesch: 49 summary: We argue that COVID-19 contact tracing may provide a unique opportunity to also conduct widespread HIV testing, among other health promotion activities. COVID-19 contact tracing may provide a unique opportunity to also conduct widespread HIV testing with modified contact tracing that could be acceptable and important for Ending the HIV Epidemic. keywords: contact; covid-19; health; hiv; testing cache: cord-297612-swc2pitd.txt plain text: cord-297612-swc2pitd.txt item: #344 of 549 id: cord-298033-kzdp9edn author: Domingo, Esteban title: Quasispecies dynamics in disease prevention and control date: 2019-11-08 words: 16379 flesch: 29 summary: Drug ReposER: a web server for predicting similar amino acid arrangements to know drug binding interfaces for potential drug repositioning Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism Amantadine-resistance as a genetic marker for influenza viruses HIV Nef: role in pathogenesis and viral fitness Mechanisms of HIV-1 escape from immune responses and antiretroviral drugs Estimating HIV evolutionary pathways and the genetic barrier to drug resistance Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection Influenza: The Last Great Plague; and Unfinished Story of Discovery The Vaccine Book Transmitted/founder viruses rapidly escape from CD8 þ T cell responses in acute hepatitis C virus infection Natural History of Infections Disease Epitope-specific CD8 þ T lymphocytes cross-recognize mutant simian immunodeficiency virus (SIV) sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection Two escape mechanisms of influenza a virus to a broadly neutralizing stalk-binding antibody Development of live-attenuated arenavirus vaccines based on codon deoptimization Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine The poliovirus eradication initiative Viral persistence in vivo through selection of neutralizing antibody-escape variants CD4þ T-cell-epitope escape mutant virus selected in vivo Perspectives and opportunities for novel antiviral treatments targeting virus fitness Human immunodeficiency virus type 1 fitness and tropism: concept, quantification, and clinical relevance HIV-1 drug resistance and resistance testing Antigenic determinants of possible vaccine escape by porcine circovirus subtype 2b viruses Trans-dominant inhibition of RNA viral replication can slow growth of drugresistant viruses Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient Vaccine development: from concept to early clinical testing Molecular and functional bases of selection against a mutation bias in an RNA virus Molecular epidemiology of hepatitis B virus mutants associated with vaccine escape, drug resistance and diagnosis failure Patterns of resistanceassociated substitutions in patients with chronic HCV infection following treatment with direct-acting antivirals Multiclass HCV resistance to direct-acting antiviral failure in real-life patients advocates for tailored secondline therapies RNA virus evolution and the control of viral disease Complications of RNA heterogeneity for the engineering of virus vaccines and antiviral agents Quasispecies dynamics in disease prevention and control Quasispecies and RNA Virus Evolution: Principles and Consequences Virus population dynamics, fitness variations and the control of viral disease: an update Viral quasispecies evolution. Higher levels of resistance mutations as a function of time in untreated patients is an indication that the mutations are not due to basal mutant frequencies but to the epidemiological expansion of virus mutants that originated in treated patients. keywords: antigenic; antiviral; cell; chapter; disease; drug; drug resistance; dynamics; escape; et al; fitness; frequency; hepatitis; infection; inhibitor; mutants; mutations; population; replication; resistance; resistance mutations; section; selection; treatment; vaccine; virus; viruses cache: cord-298033-kzdp9edn.txt plain text: cord-298033-kzdp9edn.txt item: #345 of 549 id: cord-299754-tgexahwd author: van Tol, Sarah title: The TRIMendous Role of TRIMs in Virus–Host Interactions date: 2017-08-22 words: 18335 flesch: 37 summary: Additionally, several TRIMs directly restrict viral replication either through proteasome-mediated degradation of viral proteins or by interfering with different steps of the viral replication cycle. In addition to conferring an antiviral state indirectly by regulating cytokine production downstream of PRR signaling, TRIMs are capable of restricting the effectiveness of pathogens through direct interactions with viral proteins crucial to their entry, dissemination, or life cycle [6] . keywords: activation; cells; degradation; domain; host; ifn; infection; interferon; ligase; protein; replication; response; restriction; rig; rna; role; signaling; transcription; trim25; trim5α; trims; type; ubiquitin; virus cache: cord-299754-tgexahwd.txt plain text: cord-299754-tgexahwd.txt item: #346 of 549 id: cord-299762-qr6kbwuo author: Fok, Jelle Anthony title: Genetic code expansion strategies for vaccine development date: 2020-06-30 words: 6405 flesch: 38 summary: While resulting viruses are per se replication-incompetent their production remains possible in cell-lines that express genes encoding for the missing or dysfunctional proteins. More recently, viral replication has also been controlled by installing rare codons into viral genomes to slow the translation of viral proteins (=codon deoptimization) and by the introduction of microRNAs and zinc finger nucleases that selectively break down viral RNA. keywords: antibodies; cells; immunization; influenza; mice; proteins; ptc; response; self; vaccines; viruses cache: cord-299762-qr6kbwuo.txt plain text: cord-299762-qr6kbwuo.txt item: #347 of 549 id: cord-300522-okbupw61 author: Sansone, Clementina title: Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases date: 2020-05-07 words: 4779 flesch: 24 summary: Antiviral activity of sulfated polysaccharides carrageenan from some marine seaweeds In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel Iota-carrageenan is a potent inhibitor of influenza A virus infection Antiviral Activity of a Carrageenan from Gigartina skottsbergii against Intraperitoneal Murine Herpes simplex Virus Infection Iota-Carrageenan is a potent inhibitor of rhinovirus infection Preparation and potential in vivo anti-influenza virus activity of low molecular-weight κ-carrageenans and their derivatives Galactans: An Overview of their Most Important Sourcing and Applications as Natural Polysaccharides Antiviral Potential of Algae Polysaccharides Isolated from Marine Sources: A Review Marine compounds and their antiviral activities Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales) Thus, thousands of compounds from various marine organisms such as algae, bacteria, fungi, marine invertebrates or sponges have been screened and 21 of them have demonstrated antiviral activities [17] . keywords: activities; activity; algae; antioxidant; antiviral; cell; compounds; human; infection; marine; polysaccharides; stress; virus cache: cord-300522-okbupw61.txt plain text: cord-300522-okbupw61.txt item: #348 of 549 id: cord-300642-c7adeis1 author: Lai, Andrew SH title: Viral nephropathy date: 2006 words: 4748 flesch: 31 summary: Taiwan Childhood Hepatoma Study Group Safety of immunisation and adverse events following vaccination against hepatitis B Membranoproliferative glomerulonephritis associated with hepatitis C virus infection Immunological disorders in C virus chronic active hepatitis: a prospective casecontrol study Hepatitis C, cryoglobulinemia, and cirrhosis: a meta-analysis Secondary membranoproliferative glomerulonephritis Hepatitis C virus infection and acute or chronic glomerulonephritis: an epidemiological and clinical appraisal Renal involvement in hepatitis C infection: cryoglobulinemic glomerulonephritis Long-term predictors of survival in essential mixed cryoglobulinemic glomerulonephritis Membranous glomerulonephritis associated with hepatitis C virus infection: case report and literature review Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus: Renal infection with BK virus affects kidney allograft recipients, leading to renal dysfunction and sometimes graft loss. keywords: disease; glomerulonephritis; hbv; hcv; hepatitis; hiv; immune; infection; nephropathy; patients; virus cache: cord-300642-c7adeis1.txt plain text: cord-300642-c7adeis1.txt item: #349 of 549 id: cord-300793-tuq8z6gm author: Weiss, Robin A title: Social and environmental risk factors in the emergence of infectious diseases date: 2004 words: 5855 flesch: 41 summary: A better understanding of the evolving social dynamics of emerging infectious diseases ought to help us to anticipate and hopefully ameliorate current and future risks. Emerging infectious diseases in humans comprise the following: first, established diseases undergoing increased incidence or geographic spread, for example, Tuberculosis and Dengue fever; second, newly discovered infections causing known diseases, for example, hepatitis C and Helicobacter pylori; and third, newly emerged diseases, for example, HIV/AIDS and SARS. keywords: aids; disease; emergence; hiv; human; infections; influenza; new; sars; species; spread; transmission; tuberculosis; virus; years cache: cord-300793-tuq8z6gm.txt plain text: cord-300793-tuq8z6gm.txt item: #350 of 549 id: cord-300968-dtaasxk1 author: Kliger, Yossef title: From genome to antivirals: SARS as a test tube date: 2005-03-01 words: 5118 flesch: 38 summary: The synergy between SARS fusion inhibitors and ACE2 or CD209L antagonists has not yet been investigated. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus HIV-1 entry cofactor: functional cDNA cloning of a seventransmembrane, G protein-coupled receptor CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus The HIV Env-mediated fusion reaction HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity Anti-human immunodeficiency virus interactions of SCH-C (SCH 351125), a CCR5 antagonist, with other antiretroviral agents in vitro Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100 Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion Dilation of the influenza hemagglutinin fusion pore revealed by the kinetics of individual cell-cell fusion events Kinetics of influenza hemagglutinin-mediated membrane fusion as a function of technique Kinetically differentiating influenza hemagglutinin fusion and hemifusion machines Evolution of intermediates of influenza virus hemagglutininmediated fusion revealed by kinetic measurements of pore formation HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation Early events of SARS coronavirus infection in vero cells Cloaked similarity between HIV-1 and SARS-CoV suggests an anti-SARS strategy Interaction between heptad repeat 1 and 2 regions in spike protein of SARSassociated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoproteinmediated viral entry Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus Crystal structure of SARS-CoV spike protein fusion core Structural characterization of the SARS-coronavirus spike S fusion protein core Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeatderived peptides A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3 Unique and conserved features of genome and proteome of SARScoronavirus, an early split-off from the coronavirus group 2 lineage Mechanisms and enzymes involved in SARS coronavirus genome expression The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5â�² to 3â�² viral helicases Small molecules targeting severe acute respiratory syndrome human coronavirus Immunogenic peptide comprising a mouse hepatitis virus A59 B-cell epitope and an influenza virus T-cell epitope protects against lethal infection Field study of bovine coronavirus vaccine enriched with hemagglutinating antigen for winter dysentery in dairy cows A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Inhibition of hepatitis B virus in mice by RNA interference Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA Old drugs as lead compounds for a new disease? keywords: cell; coronavirus; cov; drug; entry; fusion; hiv; inhibitors; protein; sars; syndrome cache: cord-300968-dtaasxk1.txt plain text: cord-300968-dtaasxk1.txt item: #351 of 549 id: cord-301349-m4nr3pqx author: Mirza, Muhammad Usman title: Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore‐based virtual screening approach date: 2020-09-02 words: 7397 flesch: 40 summary: All these 43 hits were comparatively docked at CXCR4 receptor to investigate their potential for dual CCR5/CXCR4 antagonists A patent review for the period from Chemokine receptor CCR5: insights into structure, function, and regulation Maraviroc (UK-427,857), a potent, orally bioavailable, and selective smallmolecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil) Synthesis and evaluation of transition metal complex dual CXCR4/CCR5 antagonists, National Spring Meeting of the Function, Bioinformatics, HIV-1 ENV gp120 structural determinants for peptide triazole dual receptor site antagonism Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR Pyrazolo-piperidines exhibit dual inhibition of CCR5/CXCR4 HIV entry and reverse transcriptase P2X1 receptor antagonists inhibit HIV-1 fusion by blocking virus-coreceptor interactions Penicillixanthone A, a marine-derived dualcoreceptor antagonist as anti-HIV-1 agent Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells A structure-based drug discovery paradigm The compromise of virtual screening and its impact on drug discovery Perspectives towards antiviral drug discovery against Ebola virus Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library Antiviral Compounds Discovered by Virtual Screening of Small− Molecule Libraries against Dengue Virus E Protein Identification of Zika virus NS2B-NS3 protease inhibitors by Structure-Based Virtual Screening and Drug Repurposing Approaches Structure-based discovery of clinically approved drugs as Zika virus NS2B-NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase OPLS3e: keywords: activity; antagonists; binding; ccr5; compounds; cxcr4; dual; energy; figure; hiv; inhibitors; interactions; ligand; receptor; residues; screening cache: cord-301349-m4nr3pqx.txt plain text: cord-301349-m4nr3pqx.txt item: #352 of 549 id: cord-301449-5okb7wf2 author: Nixon, Douglas F. title: Comments on “coinfection of SARS‐CoV‐2 and HIV in a patient in Wuhan city, China” date: 2020-04-08 words: 525 flesch: 54 summary: key: cord-301449-5okb7wf2 authors: Nixon, Douglas F. title: Comments on “coinfection of SARS‐CoV‐2 and HIV in a patient in Wuhan city, China” date: 2020-04-08 journal: J Med Virol DOI: 10.1002/jmv.25821 sha: doc_id: 301449 cord_uid: 5okb7wf2 Zhu et al. report in their letter, Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city, China, a case of COVID19 in an HIV infected patient1 . Comments on coinfection of SARS-CoV-2 and HIV in a patient in Wuhan city, China Zhu et al 1 report in their letter, coinfection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human immunodeficiency virus (HIV) in a patient in Wuhan city, China, a case of coronavirus disease 2019 in an HIV-infected patient. keywords: hiv; patient cache: cord-301449-5okb7wf2.txt plain text: cord-301449-5okb7wf2.txt item: #353 of 549 id: cord-301506-q2a5aogo author: Sun, Xinhua title: Evolution of information-driven HIV/AIDS policies in China date: 2010-12-24 words: 3942 flesch: 56 summary: We also discuss gaps in policy implementation, and challenges ahead as China continues its efforts to achieve universal access to HIV prevention, treatment and care services. Secondly, China's 'Four Frees and One Care' policy to increase access to anti-retroviral therapy (ART) was announced in late 2003 and had greatly facilitated implementation of HIV prevention, treatment and care and support. keywords: aids; care; china; health; hiv; ministry; policies; prevention; treatment cache: cord-301506-q2a5aogo.txt plain text: cord-301506-q2a5aogo.txt item: #354 of 549 id: cord-301704-mb2oylqb author: Eapen, Paul title: In Preparation for Outdoor Pharming: Griffithsin Can Be Expressed in Nicotiana excelsiana and Retains Activity After Storage as Silage date: 2020-03-18 words: 4330 flesch: 47 summary: Additionally, outdoor production of GRFT expressing plants may allow local biopharmaceutical manufacturing in areas with the greatest product needs. Ensiling plant material causes a reduction in plant mass over time with an average of 59% reduction in biomass. keywords: et al; expression; grft; griffithsin; hiv; material; plant; silage cache: cord-301704-mb2oylqb.txt plain text: cord-301704-mb2oylqb.txt item: #355 of 549 id: cord-302082-aaokc182 author: Stanberry, Lawrence R. title: Vaccines of the future date: 2011-08-31 words: 7739 flesch: 33 summary: The amino acid sequence of the viral envelope glycoprotein gp120 shows 25e35% divergence between clades and up to 20% divergence within any given clade, which constitutes a formidable hurdle to vaccine development. The future of vaccine development can build on the knowledge and experience gained over the last 200 years, and at the same time can take advantage of the most cutting-edge technologies and 194 UNDERSTANDING MODERN VACCINES research. keywords: adjuvants; antigen; candidate; cell; development; diseases; hiv; infection; influenza; responses; specific; table; vaccination; vaccine; vector; women cache: cord-302082-aaokc182.txt plain text: cord-302082-aaokc182.txt item: #356 of 549 id: cord-302321-6x7hyald author: Qiao, Shan title: Disparity in HIV Service Interruption in the Outbreak of COVID-19 in South Carolina date: 2020-08-27 words: 5004 flesch: 50 summary: AIDS Behav DOI: 10.1007/s10461-020-03013-x sha: doc_id: 302321 cord_uid: 6x7hyald To examine HIV service interruptions during the COIVD-19 outbreak in South Carolina (SC) and identify geospatial and socioeconomic correlates of such interruptions, we collected qualitative, geospatial, and quantitative data from 27 Ryan White HIV clinics in SC in March, 2020. HIV service interruptions were categorized (none, minimal, partial, and complete interruption) and analyzed for geospatial heterogeneity. keywords: care; clinics; covid-19; health; hiv; interruption; office; patients; service cache: cord-302321-6x7hyald.txt plain text: cord-302321-6x7hyald.txt item: #357 of 549 id: cord-302403-kahi8cbc author: Miller, Robert F. title: Pulmonary Infections date: 2009-05-15 words: 18178 flesch: 41 summary: The course of HIV infection can be divided clinically into several distinct periods: Acquisition of the virus Seroconversion, with or without a clinical illness (primary HIV infection) Tuberculosis HIV infection is associated with at least a 40-fold increased risk of an individual having active tuberculosis develop compared with noninfected subjects. keywords: bacterial; bal; blood; cd4; cells; counts; diagnosis; disease; drug; haart; hiv; hiv infection; individuals; infection; patients; pcp; pneumonia; prophylaxis; pulmonary; risk; therapy; treatment; tuberculosis cache: cord-302403-kahi8cbc.txt plain text: cord-302403-kahi8cbc.txt item: #358 of 549 id: cord-302530-pp6bl941 author: Gale, Paul title: How virus size and attachment parameters affect the temperature sensitivity of virus binding to host cells: Predictions of a thermodynamic model for arboviruses and HIV date: 2020-03-12 words: 14813 flesch: 54 summary: The probability, p completeT , of an arthropod midgut cell with bound virus successfully leading to infection of the arthropod salivary glands and completion of virogenesis within in the lifetime of the arthropod at temperature T is calculated using the Arrhenius equation (Eq. (15)) where p complete283 is the probability of this happening at 10°C (283 K) and E A is the activation energy of the rate-limiting step in virogenesis ( Table 2 ). The probability, p transmissionT , of arbovirus transmission by the arthropod (i.e. successful infection of the arthropod salivary glands after oral exposure) at temperature T given C.V T midgut cells have bound virus is given by Eq. keywords: a_immob; binding; cd4; et al; fig; hiv; mol; temperature; virus cache: cord-302530-pp6bl941.txt plain text: cord-302530-pp6bl941.txt item: #359 of 549 id: cord-302784-jkjdglns author: Alotaibi, Badriah title: Management of hospitalized drug sensitive pulmonary tuberculosis patients during the Hajj mass gathering: A cross sectional study date: 2019-07-13 words: 4554 flesch: 49 summary: The management of TB patients was documented using a specifically designed data collection form which included patients' demographics data, underlying health conditions and TB risk factors as well as clinical data including various aspects of TB management such as patients' screening, infection prevention and control (IPC), TB diagnosis and treatment and case notification and outcome. Only 1 (3.2%) confirmed TB patient was managed in the ER. keywords: cases; guidelines; hajj; health; management; patients; study; tuberculosis cache: cord-302784-jkjdglns.txt plain text: cord-302784-jkjdglns.txt item: #360 of 549 id: cord-302854-buzyani0 author: Prabakaran, Ponraj title: Origin, diversity, and maturation of human antiviral antibodies analyzed by high-throughput sequencing date: 2012-08-02 words: 3460 flesch: 35 summary: Among the different factors thwarting the induction of bnAbs, we previously found that all known HIV-1 bnAbs are highly divergent from germline antibodies; germline antibodies of bnAbs could not bind to the epitopes of respective mature antibodies, which led to a hypothesis that HIV-1 may have evolved to use the holes (absence of or weak binding to germline-lineaged bnAbs) in the human germline B cell receptor repertoire (Xiao et al., 2009) . For quality control of antibody sequences, we trimmed the 454 sequence data and retained only sequences of length more than 300 nucleotides (nt), covering the entire antibody variable domains consisting of the three complementarity determining regions (CDR) along with framework regions (FR). keywords: antibodies; bnabs; genes; germline; hcdr3; human; igm; intermediates cache: cord-302854-buzyani0.txt plain text: cord-302854-buzyani0.txt item: #361 of 549 id: cord-302928-nnly9ju8 author: Adachi, Akio title: Grand Challenge in Human/Animal Virology: Unseen, Smallest Replicative Entities Shape the Whole Globe date: 2020-03-18 words: 2779 flesch: 23 summary: Virology is a multidisciplinary research field and, as an academic discipline of the biology, it extensively analyzes all aspects of viruses derived from every living species by scientific systems/methodologies currently available to us as exemplified and fully described in a series of Frontiers special issues designated Research Topic (RT) in the Virology section of Frontiers in Microbiology Adachi, 2010, 2017; Miyazaki et al., 2012; Nomaguchi et al., 2012; Berkhout and Coombs, 2013; Sato et al., 2013; Adachi and Miura, 2014; Dutilh et al., 2017; Sanfaçon, 2017; Yamamoto et al., 2017) . Of socially important pathogenic viruses, some are solely tropic for humans, HIV-1 as an example (Hatziioannou et al., 2006 (Hatziioannou et al., , 2009 Kamada et al., 2006; Nomaguchi et al., 2008 Nomaguchi et al., , 2013b , and some like human norovirus are known not to replicate in cultured cells (Duizer et al., 2004; Herbst-Kralovetz et al., 2013; Ettayebi et al., 2016; Murakami et al., 2020) . keywords: animal; biology; et al; human; research; virology; viruses cache: cord-302928-nnly9ju8.txt plain text: cord-302928-nnly9ju8.txt item: #362 of 549 id: cord-303165-ikepr2p2 author: Tulchinsky, Theodore H. title: Expanding the Concept of Public Health date: 2014-10-10 words: 33923 flesch: 39 summary: In 1920, C. E. A. Winslow, professor of public health at Yale University, defined public health as follows: Public health is the Science and Art of (1) preventing disease, (2) prolonging life, and (3) Winslow's far-reaching definition remains a valid framework but is unfulfilled when clinical medicine and public health have financing and management barriers between them. The evolution of concepts of public health will have to address these new challenges of population health. keywords: action; approach; century; community health; conditions; control; countries; development; disease; environment; factors; groups; health; health care; health insurance; health issues; health promotion; health services; health status; health systems; individual; life; management; medical; mortality; national; needs; new; people; policy; population; population health; prevention; primary; programs; public; quality; resources; risk; social; world cache: cord-303165-ikepr2p2.txt plain text: cord-303165-ikepr2p2.txt item: #363 of 549 id: cord-303189-ktl4jw8v author: Coccia, Eliana M. title: Early IFN type I response: Learning from microbial evasion strategies date: 2015-03-31 words: 15234 flesch: 32 summary: Strategies, identified so far, include viral proteins that bind ISG15 or that remove ISG15 from target proteins (reviewed in [237] ). Similarly, some identified targets of viral proteins in PRR signaling pathways might be turned out to be new targets for treating a range of diseases. keywords: activation; activity; bacterial; binding; cells; cov; expression; hcv; hepatitis; host; ifn; infection; interferon; irf3; pathway; pkr; production; protein; replication; response; rig; rna; signaling; type; virus; viruses cache: cord-303189-ktl4jw8v.txt plain text: cord-303189-ktl4jw8v.txt item: #364 of 549 id: cord-303208-4bui0ioe author: Jarlais, Don C Des title: Increasing HIV prevention and care for injecting drug users date: 2010-02-26 words: 1341 flesch: 49 summary: key: cord-303208-4bui0ioe authors: Jarlais, Don C Des; Arasteh, Kamyar; Gwadz, Marya title: Increasing HIV prevention and care for injecting drug users date: 2010-02-26 journal: Lancet DOI: 10.1016/s0140-6736(10)60314-5 sha: doc_id: 303208 cord_uid: 4bui0ioe nan In The Lancet today, Bradley Mathers and colleagues 1 make a heroic eff ort-in fact, a systematic review-to document the coverage (services provided per individual in need of services) for HIV prevention and care for injecting drug users (IDUs) throughout the world. Were the vaccine to mostly go to girls in states such as Rhode Island rather than those in Mississippi, such a pattern would not only fail to match Contingency management and relapse prevention as stimulant abuse treatment interventions Syringe exchange, injecting and intranasal drug use Choices, values and frames Contributions of behavioural decision theory to research in political science Community attitudes toward HIV prevention for injection drug users: fi ndings from a cross-border project in southern China and northern Vietnam Human rights and HIV prevention among drug users keywords: drug; hiv; idus; prevention cache: cord-303208-4bui0ioe.txt plain text: cord-303208-4bui0ioe.txt item: #365 of 549 id: cord-303408-coesfldm author: Konstantinova, Pavlina title: Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome date: 2007-03-01 words: 4902 flesch: 47 summary: HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection HIV-1 Nef enhances both membrane expression and virion incorporation of Env products. However, HIV-lhNef did not replicate to detectable levels in HIV-1 target cells, probably because steps of its replication cycle are affected by the hairpin insertion, e.g. RNA splicing, RNA nuclear export or mRNA translation. keywords: cells; escape; hairpin; hiv-1; inhibition; lhnef; replication; rna; type; variants; virus cache: cord-303408-coesfldm.txt plain text: cord-303408-coesfldm.txt item: #366 of 549 id: cord-304157-u0mlee6u author: Nyasulu, Juliet title: The effects of coronavirus disease 2019 pandemic on the South African health system: A call to maintain essential health services date: 2020-07-22 words: 4421 flesch: 42 summary: Assessing the effects of COVID-19 on South African health system is critical to identify challenges and act timely to strike a balance between managing the emergency and maintaining essential health services. Assessing the effects of COVID-19 on South African health system is critical to identify challenges and act timely to strike a balance between managing the emergency and maintaining essential health services. keywords: africa; covid-19; emergency; epi; health; hiv; pandemic; services; south; system cache: cord-304157-u0mlee6u.txt plain text: cord-304157-u0mlee6u.txt item: #367 of 549 id: cord-304188-1nm1tbig author: Moody, M. Anthony title: Modulation of HIV-1 immunity by adjuvants date: 2014-04-10 words: 5163 flesch: 37 summary: The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses Vaccine adjuvants: putting innate immunity to work This is an excellent review of adjuvants and the role of PRRs in triggering the immune system. This review will highlight recent work in adjuvant development for HIV-1 vaccines with particular emphasis on antibody responses. keywords: adjuvant; antibody; cell; dna; hiv-1; human; immunization; mucosal; responses; studies; vaccine; virus cache: cord-304188-1nm1tbig.txt plain text: cord-304188-1nm1tbig.txt item: #368 of 549 id: cord-304214-66nxk4e8 author: Sanders, John W. title: Vectored immunoprophylaxis: an emerging adjunct to traditional vaccination date: 2017-02-10 words: 3752 flesch: 31 summary: Vaccines (Basel) Generation of neutralizing activity against human immunodeficiency virus type 1 in serum by antibody gene transfer Vector-mediated in vivo antibody expression Antibody-based protection against HIV infection by vectored immunoprophylaxis Broad protection against influenza infection by vectored immunoprophylaxis in mice Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice Broadly neutralizing antibodies abrogate established hepatitis C virus infection Genetic delivery of an anti-RSV antibody to protect against pulmonary infection with RSV Rapid/sustained anti-anthrax passive immunity mediated by co-administration of Ad/AAV Protection against dengue disease by synthetic nucleic acid antibody prophylaxis Rapid and long-term immunity elicited by DNA-encoded antibody prophylaxis and DNA vaccination against chikungunya virus Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission Broadly neutralizing human immunodeficiency virus type 1 antibody gene transfer protects nonhuman primates from mucosal simian-human immunodeficiency virus infection AAVexpressed eCD4-Ig provides durable protection from multiple SHIV challenges HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice Monoclonal antibodies produced by muscle after plasmid injection and electroporation A novel electroporation device for gene delivery in large animals and humans Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab Interaction of vectors and parental viruses with the host genome Development of novel adenoviral vectors to overcome challenges observed with HAdV-5-based constructs Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes AAV vectors vaccines against infectious diseases Viral vectors take on HIV infection Advances in salivary gland gene therapy -oral and systemic implications In vivo secretion of the mouse immunoglobulin G Fc fragment from rat submandibular glands General considerations on the biosafety of virus-derived vectors used in gene therapy and vaccination Viral vectors: the road to reducing genotoxicity Monoclonal gammopathy: the good, the bad and the ugly Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant None. None. Availability of data and materials Not applicable. This study provided the first evidence that rAAV vectors could transfer antibody genes to muscle, and muscle tissue was a suitable platform to produce and distribute the antibodies throughout the circulation keywords: antibodies; antibody; gene; hiv; protection; vector; vip; virus cache: cord-304214-66nxk4e8.txt plain text: cord-304214-66nxk4e8.txt item: #369 of 549 id: cord-304251-dohglrm1 author: Scully, C title: Emerging and changing viral diseases in the new millennium date: 2015-08-06 words: 6262 flesch: 37 summary: The majority of virus infections of the oral mucosa are due to the herpes group, which are DNA viruses. A critical review Human papillomavirus and survival of patients with oropharyngeal cancer Urban legends series: lichen planus Update on oral herpes virus infections Mucocutaneous manifestations of Chikungunya fever A family cluster of infections by a newly recognized bunyavirus in eastern China, 2007: further evidence of person-to-person transmission Global burden, distribution, and interventions for infectious diseases of poverty Standard infection control precautions HPV transmission in adolescent men who have sex with men Chikungunya: a re-emerging virus Global participation in core data sets for emerging pathogens Update on emerging infections: news from the Centers for Disease Control and Prevention. keywords: dengue; disease; enterovirus; et al; fever; herpes; hiv; hpv; infections; lesions; mumps; oral; syndrome; transmission; virus; viruses cache: cord-304251-dohglrm1.txt plain text: cord-304251-dohglrm1.txt item: #370 of 549 id: cord-304427-r7jt95ko author: Pasquato, A. title: Heparin enhances the furin cleavage of HIV-1 gp160 peptides date: 2007-12-22 words: 3370 flesch: 48 summary: Since CD profiles in negatively charged SDS micellar solutions showed a transition of conformers towards a more structured population, and gp160 cleavage site is positively charged, further conformational investigations were performed. It was reported that a cell-permeable 22mer sequence KIEPLGVAPTKAKRRVVQREKR 511 , which does not contain P 0 residues, interferes with gp160 processing [24] . keywords: 19mer; 41mer; cleavage; furin; gp160; heparin; peptides; processing cache: cord-304427-r7jt95ko.txt plain text: cord-304427-r7jt95ko.txt item: #371 of 549 id: cord-304748-ddwawfv2 author: Mendelsohn, Andrea S. title: COVID-19 and Antiretroviral Therapies: South Africa’s Charge Towards 90–90–90 in the Midst of a Second Pandemic date: 2020-04-30 words: 1501 flesch: 50 summary: AIDS Behav DOI: 10.1007/s10461-020-02898-y sha: doc_id: 304748 cord_uid: ddwawfv2 nan The COVID-19 pandemic has spurred panic in South Africa, a country with the highest number of HIV patients in the world and a persistent TB epidemic. In preparation for a future swell of COVID-19 patients, the Western Cape Department of Health (WC DoH) implemented a plan to de-escalate healthcare services to reduce the spread of infection and increase capacity to accommodate COVID-19 patients [2] . keywords: africa; covid-19; hiv; patients; south cache: cord-304748-ddwawfv2.txt plain text: cord-304748-ddwawfv2.txt item: #372 of 549 id: cord-304794-z2kx314h author: Métifiot, Mathieu title: G-quadruplexes in viruses: function and potential therapeutic applications date: 2014-11-10 words: 9130 flesch: 38 summary: Interestingly, TAg can unwind G4 DNA structures (122, 123) ; thus, it might play a crucial role in regulating replication as well as early and late transcription. Even if a 200-bp cis-regulatory element is necessary for efficient initiation, G4 structure formation at ORIs might be the key to selecting the firing origins (67, 68) . keywords: activity; binding; cells; dna; figure; formation; g4s; genome; human; promoter; protein; quadruplex; region; replication; rna; role; sequences; structures; transcription; viral; virus cache: cord-304794-z2kx314h.txt plain text: cord-304794-z2kx314h.txt item: #373 of 549 id: cord-304816-7gg6pxnt author: Li, Wei title: Letter to the Editor: The characteristics of two patients co‐infected with SARS‐CoV‐2 and HIV in Wuhan, China date: 2020-06-10 words: 1001 flesch: 52 summary: Although there is a lack of epidemiological investigation on whether HIV patients are susceptible to COVID-19, the above cases presented the following distinctive clinical course and manifestations. Recently, COVID-19 patients co-infected with HIV have attracted the interests of some researchers. keywords: covid-19; hiv; patients cache: cord-304816-7gg6pxnt.txt plain text: cord-304816-7gg6pxnt.txt item: #374 of 549 id: cord-304873-ppb9k3zu author: Kang, Hunseung title: Direct structural evidence for formation of a stem-loop structure involved in ribosomal frameshifting in human immunodeficiency virus type 1 1 Kumho Life and Environmental Science Laboratory Publication No. 8. 1 date: 1998-04-01 words: 2500 flesch: 60 summary: The enhancer secondary RNA structure, either a stem-loop or a pseudoknot, downstream of the shift site induces pausing of the ribosome and stimulates w x slippage at the shift sequence 4-7 . Enhancement of ribosomal frameshifting by RNA secondary structures has been studied by many mutational analyses. RNA oligonucleotides were purified by denaturing 20% polyacrylamide gel electrophoresis. keywords: frameshifting; rna; sequence; stem; structure cache: cord-304873-ppb9k3zu.txt plain text: cord-304873-ppb9k3zu.txt item: #375 of 549 id: cord-305039-grsv06j7 author: Flego, Michela title: Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases date: 2013-01-04 words: 11012 flesch: 32 summary: The MHC class II-dependent activation of resting T cells is inhibited by monoclonal antibodies to CD4 regardless whether or not they recognize epitopes involved in the binding of MHC class II or HIV gp120 Safety, pharmacokinetics, and antiretroviral activity of multiple doses of ibalizumab (formerly TNX-355), an anti-CD4 monoclonal antibody, in human immuno-deficiency virus type 1-infected adults Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1 Mouse/human chimeric monoclonal antibody in man: kinetics and immune response Phase 2 efficacy and safety of the novel entry inhibitor, TNX-355 The biology of CCR5 and CXCR4 A phase 1, doseescalation, placebo-controlled study of a fully human monoclonal antibody (CCR5mAb004) against CCR5 in patients with CCR5-tropic HIV-1 infection Potent antiviral synergy between monoclonal antibody and small-molecule CCR5 inhibitors of human immunodeficiency virus type1 A phase I study to explore the activity and safety of SCH532706, a small molecule chemokine receptor-5 antagonist in HIV type-1-infected patients Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults Transport and absorption of drugs via the lymphatic system Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseases Anti-HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibody Neutralizing antibody and antiretroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases Advancing clinical trials in cancer and viral infection: bavituximab antiviral The PD-1 pathway in tolerance and autoimmunity Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti tumor immunity Sznol M: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer Clinical trial.gov a service of the U.S. National Institutes of Health: A Study of MDX-1106 to Treat Patients with Hepatitis C Infection National Institutes of Health: Safety and Tolerability Study of the Monoclonal Antibody CT-011 in Patients with Chronic Hepatitis C Genotype 1 Infection Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients Cancer regression and autoimmunity induced by cytotoxic T lymphocyteassociated antigen 4 blockade in patients with metastatic melanoma Progress in defining CD4 helper cell responses in chronic viral infections PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications Antiviral and antitumoral effects of the anti-CTLA4 agent tremelimumab in patients with hepatocellular carcinoma (HCC) and chronic hepatitis C virus (HCV) infection: results from a phase II clinical trial AACR Annual Meeting Continuous cultures of fused cells secreting antibody of predefined specificity Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains Replacing the complementarity-determining regions in a human antibody with those from a mouse Humanized antibodies as potential therapeutic drugs An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus Antibody engineering via genetic engineering of the mouse: XenoMouse strains are a vehicle for the facile generation of therapeutic human monoclonal antibodies Selecting and screening recombinant antibody libraries Pre-publication history The pre-publication history for this paper can be accessed here Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases Authors' contributions MF and AA contributed equally to writing and editing the manuscript. The interaction of HIV envelope surface protein gp120 with its host receptor, CD4, on human T cells triggers conformational changes in the envelope, resulting in exposure of a transient binding site for co-receptor CCR5 or CXCR4. keywords: antibodies; antibody; binding; cd4; cell; chronic; hcv; hepatitis; hiv; human; immune; infected; infection; mabs; monoclonal; neutralizing; patients; pd-1; phase; receptor; virus cache: cord-305039-grsv06j7.txt plain text: cord-305039-grsv06j7.txt item: #376 of 549 id: cord-305085-bv7udg9k author: Lawrence, Robert M. title: Chapter 13 Transmission of Infectious Diseases Through Breast Milk and Breastfeeding date: 2011-12-31 words: 45867 flesch: 41 summary: Experience from the Finnish HPV family study Streptococcal toxic shock syndrome, including necrotizing fasciitis and myositis Late-onset septicemia in a Norwegian national cohort of extremely premature infants receiving very early full human milk feeding Hepatitis A outbreak in a neonatal intensive care unit: Risk factors for transmission and evidence of prolonged viral excretion among preterm infants Characterization of a novel corona virus associated with severe acute respiratory syndrome Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease Attempts to detect RNA tumour virus in human milk Is breast milk collected at home suitable for raw consumption by neonates in Brizilian public neonatal intensive care units? Prevalence of HIV-1 DNA and p24 antigen in breast milk and correlation with maternal factors Follow-up of transmission of hepatitis C to babies of human immunodeficiency virus-negative women: The role of breastfeeding in transmission Occurrence of acute diarrhea in atopic and nonatopic infants: role of prolonged breast-feeding An outbreak of methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit Hospital transmission of community acquired methicillin-resistant Staphylococcus aureus among postpartum women Removal of inhibitors against RNA-directed DNA polymerase activity in human milk Effect of human milk on mouse mammary tumor virus Human papillomavirus DNA detected in breast milk Control of a cluster of a community-associated methicillin-resistant Stahpylococcus aureus in neonatology Immunoglobulin prophylaxis against milkborne transmission of human T cell leukemia virus type 1 in rabbits Chlamydial infections Pregnancy and pulmonary tuberculosis Possible breast milk transmission of group B streptococcal infection Evidence for transmission of lymphocyte responses to tuberculin by breast-feeding, Lancet I:529 Toxic shock syndrome Detection of Borrelia burgdorferi DNA by PCR in the urine and breast milk of patients with Lyme borreliosis Prevention of perinatal group B streptococcal disease. One case of brucellosis in an infant caused by breast milk transmission, with B. melitensis isolated from the breast milk, before antibiotic treatment was given to the mother has been documented. keywords: age; antibodies; aureus; blood; breast milk; breastfed; breastfeeding; cases; children; cmv; contact; days; disease; dna; evidence; exposure; fever; group; hcv; hepatitis; hiv; hiv infection; hiv transmission; htlv; human; illness; infant transmission; infants; infection; maternal; months; mother; precautions; pregnancy; risk; specific; study; therapy; transmission; treatment; use; vaccine; virus; virus infection; virus transmission; weeks; west; women; years cache: cord-305085-bv7udg9k.txt plain text: cord-305085-bv7udg9k.txt item: #377 of 549 id: cord-305195-e41yfo89 author: Rainwater-Lovett, Kaitlin title: Viral Epidemiology: Tracking Viruses with Smartphones and Social Media date: 2016-02-12 words: 6164 flesch: 30 summary: Expanded access to the Internet and social media has revolutionized outbreak detection and viral disease surveillance by providing novel sources of data in real time (Chunara, 2012) . Investigation into the spatiotemporal dynamics of viral diseases at smaller spatial scales has become ProMED, the Program for Monitoring Emerging Diseases, is an Internet-based reporting system established in 1994 that compiles information on outbreaks of infectious diseases affecting humans, animals, and food plants. keywords: data; disease; dynamics; epidemiology; individuals; infection; influenza; methods; models; patterns; surveillance; transmission; virus; viruses cache: cord-305195-e41yfo89.txt plain text: cord-305195-e41yfo89.txt item: #378 of 549 id: cord-305394-wwabxlgr author: Venter, W D Francois title: COVID-19: First data from Africa date: 2020-08-31 words: 1471 flesch: 40 summary: Sadly, South Africa has not learnt from other African countries and their epidemics (2) . Key strengths of the paper include a dataset covering over 3 million healthcare users in the Western Cape Province, and the use of both hospitalized and nonhospitalized cases and deaths Davies' data shows similar mortality risk factors, including age, sex, diabetes (especially uncontrolled diabetes), hypertension and renal disease to other cohorts from richer countries. keywords: africa; covid-19; data; hiv; mortality cache: cord-305394-wwabxlgr.txt plain text: cord-305394-wwabxlgr.txt item: #379 of 549 id: cord-305602-yzc4bosn author: Llano, Manuel title: Chapter Seven Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions date: 2018-12-31 words: 5925 flesch: 30 summary: In this study, 35% of the 1745 genes initially found to be involved in viral protein interactions were demonstrated to influence viral replication by subsequent RNAi screening. Due to the dependency on host factors for viral replication, pharmacological disruption of the host-pathogen protein–protein interactions (PPIs) is an important therapeutic alternative to block viral replication. keywords: analysis; binding; complexes; et al; host; human; interactions; ppis; protein; replication; viral; virus; viruses cache: cord-305602-yzc4bosn.txt plain text: cord-305602-yzc4bosn.txt item: #380 of 549 id: cord-306050-y8i8759c author: García, Juan Ignacio title: Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala date: 2020-10-19 words: 5291 flesch: 43 summary: Consequently, in high TB burden settings with limited resources, sputum smear microscopy detecting acid fast bacilli (AFB) remains the main laboratory TB diagnostic test for the majority of rural health care centers In this context, Alere Determine TB LAM Ag test (LAM-test) performed in urine has great expectations for its potential to improve the diagnosis of TB in PLWH with low CD4 cell counts, and who are at greatest risk of death if TB remains undiagnosed. keywords: cd4; hiv; lam; lipoarabinomannan; mannosidase; mortality; plwh; study; test; treatment; tuberculosis; urine cache: cord-306050-y8i8759c.txt plain text: cord-306050-y8i8759c.txt item: #381 of 549 id: cord-306111-wn1gxhk9 author: Dommett, R. M. title: Mannose‐binding lectin in innate immunity: past, present and future date: 2006-09-01 words: 9072 flesch: 33 summary: Therapeutic potential of MBL MBL replacement was first attempted (without any knowledge of the deficiency) when fresh frozen plasma was given to patients and found to correct the opsonic defect (28, 29) . The mannose-binding protein A but not C is an acute phase reactant Structure of a C-type mannose-binding protein complexed with an oligosaccharide Human mannose-binding protein is identical to a component of Ra-reactive factor Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series Cutting edge: complementactivating complex of ficolin and mannose-binding lectin-associated serine protease Mannose-binding lectin accelerates complement activation and increases serum killing of Neisseria meningitidis serogroup C Activation of the lectin complement pathway by H-ficolin (Hakata antigen) Differential recognition of obligate anaerobic bacteria by human mannose-binding lectin Differential binding of mannose-binding lectin to respiratory pathogens in cystic fibrosis Human mannose-binding protein inhibits infection of HeLa cells by Chlamydia trachomatis Binding of mannan-binding protein to various bacterial pathogens of meningitis Interaction of human mannose-binding protein with Mycobacterium avium Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1 High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1 Mannose binding lectin (MBL) and HIV Mannan-binding protein and bovine conglutinin mediate enhancement of herpes simplex virus type 2 infection in mice Mannan-binding lectin modulates the response to HSV-2 infection Mannose binding protein is involved in first-line host defence: evidence from transgenic mice Binding of host collectins to the pathogenic yeast Cryptococcus neoformans: human surfactant protein D acts as an agglutinin for acapsular yeast cells Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS Recognition of plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system The major surface glycoprotein of Trypanosoma cruzi amastigotes are ligands of the human serum mannose-binding protein Novel MASP2 variants detected among North African and Sub-Saharan individuals Analysis of mannose-binding lectin 2 (MBL2) genotype and the serum protein levels in the Korean population Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferon-resistant hepatitis C virus infection in Japanese patients keywords: binding; complement; deficiency; gene; hiv; human; infection; lectin; levels; mannan; mannose; mbl; pathway; patients; protein; role; studies cache: cord-306111-wn1gxhk9.txt plain text: cord-306111-wn1gxhk9.txt item: #382 of 549 id: cord-306266-8qdrshz3 author: Scully, Crispian title: Respiratory medicine date: 2014-06-25 words: 13246 flesch: 40 summary: Respiratory infections must also be eradicated; sputum should first be sent for culture and sensitivity, but antimicrobials such as amoxicillin should be started without await ing results. Immunocompromised persons (e.g. those with human immunode ficiency virus/acquired immune deficiency syndrome [HIV/AIDS] and transplant recipients) and people with bronchiectasis or cystic fibrosis are also susceptible to respiratory infections by a range of opportun istic microbes. keywords: asthma; blood; cases; cause; chest; copd; cough; diagnosis; disease; drugs; dyspnoea; infection; influenza; lung; obstruction; oxygen; patients; people; pneumonia; pulmonary; result; risk; sputum; symptoms; syndrome; table; therapy; treatment; tuberculosis cache: cord-306266-8qdrshz3.txt plain text: cord-306266-8qdrshz3.txt item: #383 of 549 id: cord-306315-vt2e0crh author: Elabbadi, Alexandre title: Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (HIV-VIR study) date: 2020-09-14 words: 4743 flesch: 30 summary: Medicine (Baltimore) Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infection Outcome of critically ill human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy Etiology of pulmonary infections in human immunodeficiency virus-infected inpatients using sputum multiplex real-time polymerase chain reaction Impact of HIV infection and smoking on lung immunity and related disorders Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells Recording of influenza-like illness in UK primary care 1995-2013: cohort study Incidence and risk factors for influenza-like-illness in the UK: online surveillance using Flusurvey Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals Incidence of respiratory viruses in patients with community-acquired pneumonia admitted to the intensive care unit: results from the Severe Influenza Pneumonia Surveillance (SIPS) project Clinical epidemiology of bocavirus, rhinovirus, two polyomaviruses and four coronaviruses in HIV-infected and HIV-uninfected South African children Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods Virological diagnosis in community-acquired pneumonia in immunocompromised patients Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness Chronic rhinoviral infection in lung transplant recipients Persistent human rhinovirus type C infection of the lower respiratory tract in a pediatric cord blood transplant recipient Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity Viral infection in community-acquired pneumonia: a systematic review and meta-analysis Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8 + T cell response Role of tissue protection in lethal respiratory viral-bacterial coinfection Influenza virus primes mice for pneumonia from Staphylococcus aureus Pneumocystis infection enhances antibodymediated resistance to a subsequent influenza infection Diagnosis and management of respiratory viruses in critically ill adult patients: an international survey of knowledge and practice among intensivists Diagnostic value of microscopic examination of Gram-stained sputum and sputum cultures in patients with bacteremic pneumococcal pneumonia Comparison of sputum and nasopharyngeal swabs for detection of respiratory viruses Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations None. GV had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. Additional information on Material and methods, Table S1 (Panels of mPCR kits used in the two participating ICUs over the 6-year study period), Table S2 (Microbiological investigations performed in 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S3 (Baseline characteristics, behavior during ICU stay, and outcome of 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S4 (Multivariate analysis of the risk factors for death at Day-28 in 123 HIV-infected patients admitted to the ICU for acute respiratory failure), Figure S1 (Distribution of the microbiological documentations in 123 HIVinfected patients admitted to the ICU for acute respiratory failure), Figure S2 Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors Etiologies and outcome of acute respiratory failure in HIVinfected patients Temporal trends in critical events complicating HIV infection: 1999-2010 multicentre cohort study in France Survival for patients with HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy Pulmonary infections in HIV-infected patients: an update in the 21st century HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study Respiratory viruses in invasively ventilated critically ill patients-a prospective multicenter observational study Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: a single-center retrospective study Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation Procalcitonin algorithm to guide initial antibiotic therapy in acute exacerbations of COPD admitted to the ICU: a randomized multicenter study Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease Community surveillance of respiratory viruses among families in the utah better identification of germs-longitudinal viral epidemiology (BIG-LoVE) study Community-acquired pneumonia requiring hospitalization among U.S. adults Clinical significance of upper airway virus detection in critically ill hematology patients Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with HIV. keywords: acute; cd4; hiv; icu; infection; patients; study; virus cache: cord-306315-vt2e0crh.txt plain text: cord-306315-vt2e0crh.txt item: #384 of 549 id: cord-306701-hs9cfdsu author: Gona, Philimon N. title: Burden and changes in HIV/AIDS morbidity and mortality in Southern Africa Development Community Countries, 1990–2017 date: 2020-06-05 words: 6043 flesch: 49 summary: SADC HIV and AIDS strategic framework Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the global burden of disease study Institute for Health Metrics and Evaluation (IHME) What is required to end the AIDS epidemic as a public health threat by 2030? The Cost and Impact of the Fast-Track Approach PEPFAR funding and reduction in HIV infection rates in 12 focus sub-Saharan African countries: a quantitative analysis Side effects' are 'central effects' that challenge retention in HIV treatment programs in six sub-Saharan African countries: a multicountry qualitative study Prevention of HIV-1 infection with early antiretroviral therapy Sexual activity without condoms and risk of HIV transmission in sero-different couples when the HIVpositive partner is using suppressive antiretroviral therapy HIV Transmission in Male Serodiscordant Couples in Australia, Thailand and Brazil Institute for Health Metrics and Evaluation. keywords: aids; burden; countries; global; health; hiv; mortality; people; rates; sadc; study cache: cord-306701-hs9cfdsu.txt plain text: cord-306701-hs9cfdsu.txt item: #385 of 549 id: cord-306972-alyyju5x author: James, Peter Bai title: An assessment of Ebola-related stigma and its association with informal healthcare utilisation among Ebola survivors in Sierra Leone: a cross-sectional study date: 2020-02-05 words: 5891 flesch: 44 summary: We randomly sampled the required number of EVD survivors in all five districts based on proportional representation using the national list of registered Ebola survivors obtained from the Sierra Leone Association of Ebola survivors (SLAES). [43] to measure EVD related stigma among EVD survivors, as there is no detailed or validated tool exist for EVD related stigma. keywords: aids; ebola; evd; health; hiv; leone; sierra; stigma; study; survivors; t&cm cache: cord-306972-alyyju5x.txt plain text: cord-306972-alyyju5x.txt item: #386 of 549 id: cord-307817-2vy28i4m author: Lou, Zhiyong title: Current progress in antiviral strategies date: 2014-01-14 words: 7596 flesch: 32 summary: This review will highlight recent achievements in antiviral development and discuss various strategies for preventing virus attachment and entry into the host cell, as well as strategies for preventing virus replication and transcription within the host cell. Throughout the life cycle of a negative sense single-stranded RNA (ssRNA) virus, the genome length RNA is encapsidated by a virally encoded nucleoprotein (NP), instead of a naked RNA, and associated with RdRp (polymerase complex) to form a stable ribonucleoprotein (RNP) complex, which is responsible for virus replication, transcription, and assembly keywords: activity; binding; complex; function; fusion; hcv; hiv; host; infection; influenza; inhibitors; protein; replication; rna; structure; virus; viruses cache: cord-307817-2vy28i4m.txt plain text: cord-307817-2vy28i4m.txt item: #387 of 549 id: cord-308916-6p2qutc5 author: le Roux, David M. title: Community-acquired pneumonia in children — a changing spectrum of disease date: 2017-09-21 words: 4948 flesch: 29 summary: In 2005, to aid in defining outcomes of pneumococcal vaccine studies, the World Health Organization's (WHO) standardized chest radiograph description defined a group of children who were considered most likely to have pneumococcal pneumonia Thus there is convincing evidence that pneumococcal conjugate vaccination decreases the incidence of radiologic pneumonia; however there is no evidence to suggest that pneumococcal conjugate vaccination modifies the radiologic appearance of pneumococcal pneumonia. keywords: childhood; children; conjugate; countries; disease; incidence; income; pneumonia; vaccination cache: cord-308916-6p2qutc5.txt plain text: cord-308916-6p2qutc5.txt item: #388 of 549 id: cord-309242-ilsupfl8 author: Schuchat, Anne title: Global health and the US Centers for Disease Control and Prevention date: 2014-07-02 words: 2887 flesch: 42 summary: The world is more interconnected than ever, and weak links in public health capacity anywhere can have profound eff ects at distant locations. CDC's global health strategy aims to: achieve optimum health eff ects; strengthen global health capacity; improve global health security; and strengthen the organisation's capacity. keywords: cdc; countries; global; health; hiv; infl; public; uenza; virus cache: cord-309242-ilsupfl8.txt plain text: cord-309242-ilsupfl8.txt item: #389 of 549 id: cord-309489-ubf55eux author: Carvalho, John J. title: OUR COMMON ENEMY: COMBATTING THE WORLD'S DEADLIEST VIRUSES TO ENSURE EQUITY HEALTH CARE IN DEVELOPING NATIONS date: 2009-02-19 words: 5292 flesch: 35 summary: Although HIV/AIDS is considered the most pressing worldwide concern for scientists, dengue virus is also alarming. Given the possibility for severe disease in infected individuals and the ease by which dengue is transmitted by mosquitoes, the spread of dengue virus could be considered one of the most dangerous emerging threats facing the world. keywords: aids; care; dengue; health; hiv; nations; rotavirus; science; viruses cache: cord-309489-ubf55eux.txt plain text: cord-309489-ubf55eux.txt item: #390 of 549 id: cord-309515-0pxl0sta author: Blanco, Jose L title: COVID-19 in patients with HIV: clinical case series date: 2020-04-15 words: 1009 flesch: 49 summary: a l s in all three patients who had pneumonia (patients 2, 4, and 5), and corticosteroids in two patients (patients 4 and 5) and tocilizumab in one (patient 2). Finally, in advanced patients (ie, late presenters), we must ensure differential diagnosis and initial antimicrobial treatment to address pulmonary opportunistic infections (eg, Pneumocystis jirovecii, as seen in patient 5) presenting with similar clinical and radiological symptoms. keywords: covid-19; hiv; patients cache: cord-309515-0pxl0sta.txt plain text: cord-309515-0pxl0sta.txt item: #391 of 549 id: cord-309900-4nln90jn author: Doornekamp, Laura title: Experience with a Multinational, Secondary School Education Module with a Focus on Prevention of Virus Infections date: 2017-07-12 words: 7906 flesch: 50 summary: A review of the research Social desirability in crosscultural research Evaluation of a school-based HIV prevention intervention among Yemeni adolescents Effects of a rapid peer-based HIV/AIDS educational intervention on knowledge and attitudes of high school students in a high-income Arab country Effectiveness of a peer-led HIV prevention intervention in secondary schools in Rwanda: results from a non-randomized controlled trial An evaluation of a peerbased HIV/AIDS education program as implemented in a suburban high school setting Effectiveness of school-based education on HIV/AIDS knowledge, attitude, and behavior among secondary school students in Wuhan Characteristics of effective interventions in improving young people's sexual health: a review of reviews Effectiveness of a school HIV/AIDS prevention program for Spanish adolescents Evaluation of HIV/AIDS secondary school peer education in rural Nigeria Longitudinal study of a school based HIV/AIDS early prevention program for Mexican adolescents Effectiveness of an HIV prevention program for secondary school students in Mongolia Peer-led health education among high school students The effect of school-based cervical cancer education on perceptions towards human papillomavirus vaccination among Hong Kong Chinese adolescent girls An educational programme on dengue fever prevention and control for females in Jeddah high schools Effects of an influenza prevention program using non-pharmaceutical prevention measures to improve the knowledge, attitudes and practices of elementary school students in Nakhon Phanom province Countries and Economies Stichting Technasium The Surinamese Education System Described and Compared with the Dutch System The Indonesian Education System Described and Compared with the Dutch System Learning effects of an international group competition project Where's the evidence that active learning works? keywords: attitude; behavior; country; education; group; intervention; knowledge; module; netherlands; school; students; suriname cache: cord-309900-4nln90jn.txt plain text: cord-309900-4nln90jn.txt item: #392 of 549 id: cord-310430-7eww1oet author: Singh, Ram Sarup title: Algal lectins as promising biomolecules for biomedical research date: 2013-07-16 words: 6080 flesch: 34 summary: key: cord-310430-7eww1oet authors: Singh, Ram Sarup; Thakur, Shivani Rani; Bansal, Parveen title: Algal lectins as promising biomolecules for biomedical research date: 2013-07-16 journal: Crit Rev Microbiol DOI: 10.3109/1040841x.2013.798780 sha: doc_id: 310430 cord_uid: 7eww1oet Lectins are natural bioactive ubiquitous proteins or glycoproteins of non-immune response that bind reversibly to glycans of glycoproteins, glycolipids and polysaccharides possessing at least one non-catalytic domain causing agglutination. Comprehensively, algal lectins are used in biomedical research for antiviral, antinociceptive, anti-inflammatory, anti-tumor activities, etc. and in pharmaceutics for the fabrication of cost-effective protein expression systems and nutraceutics. keywords: activity; algal; anti; binding; blood; carbohydrate; cells; erythrocytes; et al; hiv; human; lectin; marine; red; specificity; virus cache: cord-310430-7eww1oet.txt plain text: cord-310430-7eww1oet.txt item: #393 of 549 id: cord-310867-78cx3o29 author: Mo, Phoenix K. H. title: Stigmatization among people living with HIV in Hong Kong: A qualitative study date: 2017-02-14 words: 3926 flesch: 43 summary: The effects of HIV stigma on health, disclosure of HIV status, and risk behavior of homeless and unstably housed persons living with HIV Meta-analysis of health and demographic correlates of stigma towards people living with HIV A model of suicidal ideation in adults aging with HIV The association of stigma with self-reported access to medical care and antiretroviral therapy adherence in persons living with HIV/AIDS HIV stigma and missed medications in HIV-positive people in five African countries Intentionality of medication non-adherence among individuals living with HIV/AIDS in Hong Kong Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesis Exploring HIV stigma and quality of life for persons living with HIV infection Associations between perceived HIV stigma and quality of life at the dyadic lvel: the actor-partner interdependence model Internalization of stigma for parents of children with autism spectrum disorder in Hong Kong Cognitive insight and causal attribution in the development of self-stigma among individuals with schizophrenia Examining attribution model of self-stigma on social support and psychological well-being among people with HIV+ Personal meaning, social support, and perceived stigma in individuals receiving HIV mental health services Mass media and HIV/AIDS in China Chinese newspapers' coverage of HIV transmission over a decade (2000-2010): where HIV stigma arises A pragmatic view of thematic analysis Transforming Qualitative Information: Thematic Analysis and Code Development Competing paradigms in qualitative research Understanding interrelationships among HIV-related stigma, concern about HIV infection, and intent to disclose HIV serostatus: a pretest-posttest study in a rural area of eastern China Joint United Nations Programme on HIV/AIDS. HIV interventions to reduce HIV/AIDS stigma: a systematic review A HIV stigma reduction intervention for people living with HIV and their families Combating HIV stigma in health care settings: what works? keywords: hiv; hong; kong; level; plhiv; self; stigma; study cache: cord-310867-78cx3o29.txt plain text: cord-310867-78cx3o29.txt item: #394 of 549 id: cord-310931-5165078t author: Oppong, Joseph R. title: Globalization of Communicable Diseases date: 2019-12-04 words: 3191 flesch: 43 summary: To avoid a global pandemic of flu virus, new vaccine technologies are required, to respond quickly and effectively to new challenges of communicable disease outbreaks. key: cord-310931-5165078t authors: Oppong, Joseph R. title: Globalization of Communicable Diseases date: 2019-12-04 journal: International Encyclopedia of Human Geography DOI: 10.1016/b978-0-08-102295-5.10438-x sha: doc_id: 310931 cord_uid: 5165078t Fueled by globalization and human behavior, communicable diseases pose a serious threat to humankind despite unparalleled technological advances. keywords: cases; communicable; disease; hiv; people; transmission; virus cache: cord-310931-5165078t.txt plain text: cord-310931-5165078t.txt item: #395 of 549 id: cord-311366-uodq4foi author: Sanyal, Anwesha title: Neisseria gonorrhoeae uses cellular proteins CXCL10 and IL8 to enhance HIV‐1 transmission across cervical mucosa date: 2019-04-11 words: 5554 flesch: 41 summary: The role of bacterial vaginosis and trichomonas in HIV transmission across the female genital tract Microbiome in human immunodeficiency virus infection Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts Cofactors in malefemale sexual transmission of human immunodeficiency virus type 1 The role of sexually transmitted diseases in HIV transmission Neisseria gonorrhoeae and Chlamydia trachomatis among human immunodeficiency virus-infected women Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and women Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells Cytokine and antibody responses in women infected with Neisseria gonorrhoeae: effects of concomitant infections Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication Pathogen recognition in the human female reproductive tract: expression of intracellular cytosolic sensors NOD1, NOD2, RIG-1, and MDA5 and response to HIV-1 and Neisseria gonorrhea Increase in endocervical CD4 lymphocytes among women with nonulcerative sexually transmitted diseases Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation Neisseria gonorrhoeae induced disruption of cell junction complexes in epithelial cells of the human genital tract Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1 T lymphocyte response to Neisseria gonorrhoeae porin in individuals with mucosal gonococcal infections Induction of HIV-1 long terminal repeat-mediated transcription by Neisseria gonorrhoeae Inhibiting sexual transmission of HIV-1 infection Target cells in vaginal HIV transmission HIV infection of the genital mucosa in women Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis Targeting early infection to prevent HIV-1 mucosal transmission Glycerol monolaurate prevents mucosal SIV transmission The laboratory diagnosis of Neisseria gonorrhoeae Construction and characterization of a derivative of Neisseria gonorrhoeae strain MS11 devoid of all opa genes Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system A semiquantitative assay for CD8+ Tcell-mediated suppression of human immunodeficiency virus type 1 infection Dependence of CD8+ T-cell-mediated suppression of HIV type 1 on viral phenotypes and mediation of phenotype-dependent suppression by viral envelope gene and not by beta-chemokines Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract Study of HIV-1 transmission across cervical mucosa to tonsil tissue cells using an organ culture Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture Improved detection of simian immunodeficiency virus RNA by in situ hybridization in fixed tissue sections: combined effects of temperatures for tissue fixation and probe hybridization Simian immunodeficiency virus infection alters chemokine networks in lung tissues of cynomolgus macaques: association with Pneumocystis carinii infection Simian immunodeficiency virus infection potently modulates chemokine networks and immune environments in hilar lymph nodes of cynomolgus macaques Isolation, characterization, and functional analysis of ferret lymphatic endothelial cells Surface pattern differentiation of the epithelial cells of the human uterine ectocervix Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides Inflammatory cytokines produced in response to experimental human gonorrhea Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo Analysis of Tat function in human immunodeficiency virus type 1-infected low-level-expression cell lines U1 and ACH-2 Type IV pili of Neisseria gonorrhoeae influence the activation of human CD4+ T cells HIV exposure to the epithelia in ectocervical and colon tissues induces inflammatory cytokines without tight junction disruption CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination Pivotal role of dendritic cellderived CXCL10 in the retention of T helper cell 1 lymphocytes in secondary lymph nodes Dual role of macrophages in tumor growth and angiogenesis Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors Catechins inhibit CXCL10 production from oncostatin M-stimulated human gingival fibroblasts Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fibroblasts NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFNgamma in human intestinal epithelial cell lines Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC Chalcone derivatives: anti-inflammatory potential and molecular targets perspectives Such analysis identified with high statistical significance (P ≤ 0.05) 33 differentially expressed (−3 to 8-fold) genes in NG exposed and 7 differentially expressed (2 to 7-fold) genes in HIV-1 exposed tissues, compared to part of the same tissues exposed to control medium (Tables S1 and S2 ). keywords: analysis; cells; control; exposure; fold; genes; human; infection; neisseria; tissues; transmission cache: cord-311366-uodq4foi.txt plain text: cord-311366-uodq4foi.txt item: #396 of 549 id: cord-311559-vkb7a4cm author: Kanwugu, Osman N. title: HIV/SARS‐CoV‐2 coinfection: A global perspective date: 2020-07-28 words: 2490 flesch: 38 summary: Global HIV & AIDS statistics -2020 fact sheet What does the COVID-19 pandemic mean for HIV, tuberculosis, and malaria control Challenges to HIV care and psychological health during the COVID-19 pandemic among people living with HIV in China COVID-19 pandemic disrupts HIV continuum of care and prevention: implications for research and practice concerning community-based organizations and frontline providers Disruption to HIV treatment in Africa during COVID-19 pandemic could double HIV deaths, modelling studies warn HIV services take a backseat to COVID-19 in Russia Living with HIV in the time of COVID-19: a glimpse of hope Public health, health systems and palliation planning for COVID-19 on an exponential timeline HIV care in times of the COVID-19 crisis-where are we now in Central and Eastern Europe? Lockdown fears for key populations A rapid assessment of the impact of the new coronavirus pneumonia epidemic on the health needs of HIV-infected patients HIV care in Central and Eastern Europe: How close are we to the target? Crisis for people living with HIV in Indonesia The burden of COVID-19 in people living with HIV: a syndemic perspective Potential impact of SARS-CoV-2 infection in HIV-positive patients in South Africa Strengthening health research capacity in sub-Saharan Africa: mapping the 2012-2017 landscape of externally funded international postgraduate training at institutions in the region Building research capacity in Africa: equity and global health collaborations Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Clinical features and outcomes of HIV patients with coronavirus disease 2019 Description of COVID-19 in HIV-infected individuals: a single-centre SARS-CoV-2 co-infected patients in Istanbul, Turkey Hospitalized patients with COVID-19 and HIV: a case series Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19 Epidemiologic and clinical characteristics of 26 cases of COVID-19 arising from patient-to-patient transmission in Liaocheng, China Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship COVID-19 in patients with HIV: clinical case series Clinical characteristics and outcomes in people living with HIV hospitalized for COVID-19 Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis Mortality analyses 4 Cases: HIV and SARS-CoV-2 co-infection in patients from Long Island Clinical features and outcome of HIV/ SARS-CoV-2 co-infected patients in the Bronx SARS-CoV-2: recent reports on antiviral therapies based on lopinavir/ritonavir, darunavir/ umifenovir, hydroxychloroquine, remdesivir, favipiravir and other drugs for the treatment of the new coronavirus Could HIV infection alter the clinical course of SARS-CoV-2 infection? In addition, there have been reports that several HIV/ AIDS prevention and control centers globally have been converted to COVID-19 treatment centers, which denies HIV patients of their ART. keywords: case; cov-2; covid-19; hiv; infection; patients; sars cache: cord-311559-vkb7a4cm.txt plain text: cord-311559-vkb7a4cm.txt item: #397 of 549 id: cord-311679-m6poosn3 author: Santos, Glenn-Milo title: Economic, Mental Health, HIV Prevention and HIV Treatment Impacts of COVID-19 and the COVID-19 Response on a Global Sample of Cisgender Gay Men and Other Men Who Have Sex with Men date: 2020-07-11 words: 5588 flesch: 39 summary: We characterized the economic, mental health, HIV prevention and HIV treatment impacts of COVID-19 and the COVID-19 response, and examined whether sub-groups of our study population are disproportionately impacted by COVID-19. New data on from the U.S. has not only reinforced this point but also underscored the ongoing need for uninterrupted access to HIV prevention tools gay men and other MSM may need [13] . keywords: access; covid-19; gay; health; hiv; men; msm; prevention; sex cache: cord-311679-m6poosn3.txt plain text: cord-311679-m6poosn3.txt item: #398 of 549 id: cord-312167-d16ylykc author: Lazzarin, Serena Marita title: Successful treatment of HIV-associated tumefactive demyelinating lesions with corticosteroids and cyclophosphamide: a case report date: 2020-11-03 words: 840 flesch: 35 summary: However, in literature, no data are available for steroid-unresponsive TDLs in HIV patients [5] . Neuroradiological and pathological findings were suggestive of tumefactive demyelinating lesions (TDLs). keywords: data; hiv; lesions; paper cache: cord-312167-d16ylykc.txt plain text: cord-312167-d16ylykc.txt item: #399 of 549 id: cord-312194-1jiaghrb author: Brondani, M. title: The HIV and SARS-CoV-2 Parallel in Dentistry from the Perspectives of the Oral Health Care Team date: 2020-09-18 words: 4770 flesch: 45 summary: Future studies should include oral health care providers across Canada, as well as the patients receiving oral health care during this pandemic. M. Brondani, contributed to conception, design, data acquisition, analysis, and interpretation, drafted and critically revised the manuscript; L. Donnelly, contributed to data analysis and interpretation, critically revised the manuscript. Future studies should include other providers across Canada, as well the patients receiving oral health care during this pandemic. keywords: aids; care; covid-19; dental; health; hiv; pandemic; participants cache: cord-312194-1jiaghrb.txt plain text: cord-312194-1jiaghrb.txt item: #400 of 549 id: cord-312332-rwmuucsp author: Dicker, Kate title: The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity date: 2020-09-10 words: 9241 flesch: 41 summary: The human RNA-Binding proteome and its dynamics during translational arrest Purification of cross-linked RNA-protein complexes by phenol-toluol extraction Comprehensive identification of RNA-Binding domains in human cells High-resolution mapping of RNA-Binding regions in the nuclear proteome of embryonic stem cells The new (dis)order in RNA regulation Two RNA polymerase complexes from vesicular stomatitis virus-infected cells that carry out transcription and replication of genome RNA Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches Comprehensive proteomic analysis of influenza virus polymerase complex reveals a novel association with mitochondrial proteins and RNA polymerase accessory factors Discovery of widespread host protein interactions with the prereplicated genome of CHIKV using VIR-CLASP Fields Virology Diverse roles of host RNA binding proteins in RNA virus replication https://doi.org/10.1016/j.semcdb.2020.08.002. Thiouracil cross-linking mass spectrometry: a cell-based method to identify host factors involved in viral amplification Identification of proteins bound to dengue viral RNA in vivo reveals new host proteins important for virus replication Identification of RNA binding proteins associated with dengue virus RNA in infected cells reveals temporally distinct host factor requirements Elucidating the in vivo interactome of HIV-1 RNA by hybridization capture and mass spectrometry Unconventional RNA-binding proteins step into the virus-host battlefront Identification and characterization of sindbis virus RNA-Host protein interactions System-wide profiling of RNA-Binding proteins uncovers key regulators of virus infection An RNA-centric dissection of host complexes controlling flavivirus infection Viruses seen by our cells: the role of viral RNA sensors Intracellular sensing of viral genomes and viral evasion To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts Insights into RNA biology from an atlas of mammalian mRNAbinding proteins A brave new world of RNAbinding proteins Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS) keywords: assembly; binding; cell; hiv-1; host; human; infection; particles; proteins; rbps; replication; rna; role; transcription; virion; virus; viruses; vrna cache: cord-312332-rwmuucsp.txt plain text: cord-312332-rwmuucsp.txt item: #401 of 549 id: cord-312513-mad9xkz8 author: Iordanou, Stelios title: Severe SARS‐CoV‐2 pneumonia in a 58‐year‐old patient with HIV: a clinical case report from the Republic of Cyprus date: 2020-05-25 words: 694 flesch: 40 summary: COVID-19 was finally confirmed from a third nasopharyngeal/oropharyngeal sample on hospital day 6. The patient progressively developed severe acute respiratory distress syndrome (ARDS) (Figure 1 ) with a PO2/FiO2 ratio of 55mmHg on hospital day 7; he was electively intubated and admitted to the ICU (Table 1) . keywords: day; hiv; patient cache: cord-312513-mad9xkz8.txt plain text: cord-312513-mad9xkz8.txt item: #402 of 549 id: cord-313617-hh7lccet author: Sigel, Keith title: Covid-19 and People with HIV Infection: Outcomes for Hospitalized Patients in New York City date: 2020-06-28 words: 2566 flesch: 45 summary: [13] Larger uncontrolled series from New Jersey (13 hospitalized patients), New York City (31 hospitalized patients) and Madrid, Spain (28 hospitalized patients) also subsequently demonstrated COVID-19 outcomes for PWH similar to those described for the general population. We collected data on baseline clinical characteristics, laboratory values, HIV infection status, COVID-19 treatment, and outcomes from this group and matched comparators (one PWH to up to five patients by age, sex, race/ethnicity and calendar week of infection). keywords: covid-19; hiv; pwh cache: cord-313617-hh7lccet.txt plain text: cord-313617-hh7lccet.txt item: #403 of 549 id: cord-313729-mydyc68y author: McDiarmid, Melissa A. title: Hazards of the Health Care Sector: Looking Beyond Infectious Disease date: 2014-11-25 words: 2952 flesch: 41 summary: World Health Organization Update on the subject of epidemiology of blood-transmitted occupational infections A caseecontrol study of HIV seroconversion in health care workers after percutaneous exposure Joint WHO/ILO guidelines on post exposure prophylaxis (PEP) to prevent HIV infection Aide mémoire for a strategy to protect health workers from infection with bloodborne viruses Preventing chronic disease: a vital investment Chemcial in the Health Care Environment. 6 In the context of this highly complex and hazardous work environment, particular challenges arise in pursuing protections for health care workers in this unique employment sector. keywords: care; control; drugs; exposure; hazard; health; settings; workers cache: cord-313729-mydyc68y.txt plain text: cord-313729-mydyc68y.txt item: #404 of 549 id: cord-314098-1i6c0l3e author: Hayward, Joshua A title: Differential Evolution of Antiretroviral Restriction Factors in Pteropid Bats as Revealed by APOBEC3 Gene Complexity date: 2018-03-29 words: 6811 flesch: 40 summary: These results show that bat A3 proteins are functionally active and can mutate cytosines in a diverse range of dinucleotide contexts. The antiviral activity of bat A3 proteins was determined by assessing the capacity of representatives of each bat A3 subtype to restrict HIV-1 infectivity in target cells. keywords: a3z1; alecto; analysis; apobec3; bat; bats; et al; gene; human; proteins; pteropid; retroviruses; sequence; supplementary; vampyrus cache: cord-314098-1i6c0l3e.txt plain text: cord-314098-1i6c0l3e.txt item: #405 of 549 id: cord-314331-7k0oym5i author: Menza, Timothy W. title: Rapid Uptake of Home-Based HIV Self-testing During Social Distancing for SARS-CoV2 Infection in Oregon date: 2020-06-27 words: 2378 flesch: 52 summary: Finally, home HIV testing allowed participants to test without risking exposure to SARS-CoV2 infection in a healthcare setting. In partnership with Building Healthy Online Communities (BHOC), on March 31, 2020, one week after a stay-home order was issued in Oregon [12] , we launched a pilot of a free, mail-order, home HIV testing program targeted to MSM. keywords: hiv; home; men; oregon; program; testing cache: cord-314331-7k0oym5i.txt plain text: cord-314331-7k0oym5i.txt item: #406 of 549 id: cord-314528-5yq95giq author: Hirayama, Makoto title: High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120 date: 2015-12-12 words: 8241 flesch: 47 summary: We searched higher plant lectins similar to KAAs by in silico screening for genome sequences of soybean Glycine max, rice Oryza sativa, and Arabidopsis; however, higher plant genomes encode no lectins similar to this lectin family (data not shown) as Jiang et al. (2010) reported a genome wide screening of higher plant lectins. keywords: amino; anti; binding; cells; fig; glycans; gp120; hiv; kaas; lectin; mannose; peptide; rkaa-1; sequence; virus cache: cord-314528-5yq95giq.txt plain text: cord-314528-5yq95giq.txt item: #407 of 549 id: cord-314560-rswa5zdn author: Manjunath, N. title: Interfering antiviral immunity: application, subversion, hope? date: 2006-06-06 words: 5889 flesch: 39 summary: In the context of RNA viruses, siRNAs can be designed to degrade not only viral mRNA Similarly, Ge et al. achieved and Polio), for which a single mRNA is used to transcribe viral proteins, targeting any part of the coding sequence should result in degradation (scissors) of viral genomic RNA and/or progeny mRNA. keywords: cells; delivery; gene; infection; interference; protein; rnai; sequence; silencing; sirna; targeting; virus; viruses cache: cord-314560-rswa5zdn.txt plain text: cord-314560-rswa5zdn.txt item: #408 of 549 id: cord-314753-xflhxb13 author: Manso, Carmen F. title: Efficient and unbiased metagenomic recovery of RNA virus genomes from human plasma samples date: 2017-06-23 words: 6344 flesch: 38 summary: key: cord-314753-xflhxb13 authors: Manso, Carmen F.; Bibby, David F.; Mbisa, Jean L. title: Efficient and unbiased metagenomic recovery of RNA virus genomes from human plasma samples date: 2017-06-23 journal: Sci Rep DOI: 10.1038/s41598-017-02239-5 sha: doc_id: 314753 cord_uid: xflhxb13 RNA viruses cause significant human pathology and are responsible for the majority of emerging zoonoses. The percentage of reads mapping to RNA virus genomes in the rRNA-depleted BBV Panel samples was between 40 and 150-fold higher than in corresponding untreated controls. keywords: genome; hcv; hiv; human; mapping; panel; plasma; reads; rna; rrna; samples; sequences; virus; viruses cache: cord-314753-xflhxb13.txt plain text: cord-314753-xflhxb13.txt item: #409 of 549 id: cord-315687-stgj6olw author: Demma, LJ title: Evolution of the uniquely adaptable lentiviral envelope in a natural reservoir host date: 2006-03-20 words: 6454 flesch: 40 summary: Thus SIVsm V1V2 sequence diversity in the natural SM host is at least as great as, if not greater than that observed in HIV-1-infected humans, especially given that the archival nature of proviral sequences may overestimate the diversity of the actively replicating viral RNA population [47] Our observation of an inverse relationship between N-glyc site density and SIVsm V1V2 sequence diversity might result from the more highly gly-cosylated viral variants being better shielded from the diversifying selection pressures of anti-SIV antibodies than less glycosylated variants, as recently suggested for HIV keywords: diversity; env; hiv; host; human; immunodeficiency; sequence; sivsm; species; time; v1v2; variation; virus; viruses cache: cord-315687-stgj6olw.txt plain text: cord-315687-stgj6olw.txt item: #410 of 549 id: cord-315918-12rbbe8c author: Mukherjee, Pulok K. title: Antiviral Evaluation of Herbal Drugs date: 2019-06-21 words: 12824 flesch: 39 summary: Many combinations of test viruses are possible, but a battery of six viruses seems to be quite acceptable. This assay is applicable for HIV-1, simian immunodeficiency virus (SIV), and simian-HIV and is carried out in TZM-bl cells as it reveal the reduction in Tat-induced luciferase (Luc) reporter gene expression after a single round of virus infection. keywords: acid; activities; activity; antiviral; assay; cells; compounds; control; culture; drug; et al; extracts; herpes; hiv; incubate; infection; medicinal; medium; plant; replication; screening; test; virus; viruses cache: cord-315918-12rbbe8c.txt plain text: cord-315918-12rbbe8c.txt item: #411 of 549 id: cord-316273-vo6j8zb0 author: Cosset, François-Loic title: Cell Entry of Enveloped Viruses date: 2011-02-08 words: 23445 flesch: 28 summary: Vectors derived from HIV pseudotyped with Sendai virus fusion protein F (Kowolik and Yee, 2002) or E1E2 from hepatitis C virus (Bartosch et al., 2003) , and such vectors are able to transduce human hepatoma cells and primary human hepatocytes efficiently, although they are unable to enter nonliver cells. Both p62 and prM are cleaved by the cellular protease furin late in the secretory pathway, in a maturation reaction that is a crucial regulatory step for subsequent virus fusion (Salminen et al., 1992; Stadler et al., 1997; Wengler, 1989; Zhang et al., 2003a) . keywords: activation; binding; c virus; cell; cell fusion; changes; class; cleavage; domain; ebola; endocytosis; entry; envelope; envelope glycoprotein; envgp; et al; fusion; fusion peptide; fusion proteins; glycoprotein; hepatitis; hiv; hiv-1; host; human; infection; inhibitors; membrane fusion; pathway; process; receptor; structure; surface; transmembrane; type; virus; virus entry; virus fusion; virus glycoprotein; viruses cache: cord-316273-vo6j8zb0.txt plain text: cord-316273-vo6j8zb0.txt item: #412 of 549 id: cord-316534-ep7ezoko author: Gamble, Lena J title: Current progress in the development of a prophylactic vaccine for HIV-1 date: 2010-12-22 words: 11976 flesch: 31 summary: 148, 253 In an effort to develop HIV-1 vaccines, researchers within this same group generated combinatorial libraries of HRV capsid-incorporated HIV-1 gp41 epitope. 149 Commercial and clinical Ad development of HIV-1 vaccines have progressed preferentially more than vector systems such as HRV because the flexibility of Ad generally exceeds current rhinovirus systems. keywords: ad5; adenovirus; aids; cell; development; dna; gene; hiv; human; immunity; immunodeficiency; infection; mucosal; protection; protein; recombinant; response; type; use; vaccination; vaccine; vectors; virus cache: cord-316534-ep7ezoko.txt plain text: cord-316534-ep7ezoko.txt item: #413 of 549 id: cord-316789-nb4437qs author: Omel’yanchuk, L. V. title: Drosophila melanogaster as a model for studying the function of animal viral proteins date: 2011-07-16 words: 3482 flesch: 47 summary: Irrespective of currently available large collections of mutant strains, it becomes more conve nient to study the function of Drosophila genes with the use of rather elaborate transgenic constructs [4] . These possibilities, initially devel oped for genetic analysis of Drosophila genes, can also be used to analyze the functions of foreign genes. keywords: authors; bzlf1; cell; drosophila; expression; genes; hiv; human; protein; virus cache: cord-316789-nb4437qs.txt plain text: cord-316789-nb4437qs.txt item: #414 of 549 id: cord-316904-g7dli0a8 author: Chang, Hernan R. title: Role of cytokines in AIDS wasting date: 1998-12-31 words: 8304 flesch: 31 summary: However, subsequent studies failed to show high-serum TNF levels in most AIDS patients, and no correlation appeared to exist between serum TNF levels and the magnitude of weight loss in AIDS patients. In AIDS patients with anorexia and weight loss, conversion of thyroxine to T3 is decreased (euthyroid sick syndrome) as well as the levels of insulin-like growth factor-I (IGF-I), whereas in stable HIV patients T3 levels are normal. keywords: aids; body; cytokines; effects; factor; hiv; il-1; infection; levels; muscle; patients; role; tnf; wasting; weight cache: cord-316904-g7dli0a8.txt plain text: cord-316904-g7dli0a8.txt item: #415 of 549 id: cord-317037-1qydcc5e author: Kumar, Asit title: Extracellular Vesicles in Viral Replication and Pathogenesis and Their Potential Role in Therapeutic Intervention date: 2020-08-13 words: 9424 flesch: 28 summary: Notably, EVs can enhance viral infection by: (1) mediating transfer of chemokine co-receptors or cell surface proteins to null-target cells that do not express endogenous viral co-receptors; (2) helping viruses to evade the host immune system; (3) transferring of viral components (viral proteins and RNAs) to recipient cells, which induce cytotoxic effects on infected cells, leading to progressive loss of immune cells resulting from the apoptosis of uninfected bystander cells. Notably, EVs can enhance viral infection by: (1) mediating transfer of chemokine co-receptors or cell surface proteins to null-target cells that do not express endogenous viral co-receptors; (2) helping viruses to evade the host immune system; (3) transferring of viral components (viral proteins and RNAs) to recipient cells, which induce cytotoxic effects on infected cells, leading to progressive loss of immune cells resulting from the apoptosis of uninfected bystander cells. keywords: cells; delivery; drug; evs; exosomes; extracellular; hiv; human; immune; infected; infection; isolation; membrane; plasma; proteins; replication; rna; sars; size; vesicles; virus; viruses cache: cord-317037-1qydcc5e.txt plain text: cord-317037-1qydcc5e.txt item: #416 of 549 id: cord-317213-vhprfb1o author: Tram, Dai Thien Nhan title: Advances in nanomaterials and their applications in point of care (POC) devices for the diagnosis of infectious diseases date: 2016-09-26 words: 11582 flesch: 39 summary: Apart from the aforementioned strengths of this system, it did exhibit certain limitations (Zhu et al., 2014) . More recently, Zhu et al. developed an immunoassay based on similar concepts, but with certain alterations to expunge the existing drawbacks (Zhu et al., 2014) . keywords: acid; amplification; antibodies; assay; aunps; detection; diagnosis; dna; ecm; et al; gold; hiv; lod; magnetic; nps; nucleic; poc; range; sample; sensitivity; size; system; time; virus cache: cord-317213-vhprfb1o.txt plain text: cord-317213-vhprfb1o.txt item: #417 of 549 id: cord-317277-rr9zue4l author: Cifuentes-Munoz, Nicolas title: Viral cell-to-cell spread: Conventional and non-conventional ways date: 2020-09-29 words: 13111 flesch: 30 summary: Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies Extracellular vesicles: vehicles of en bloc viral transmission Casein kinase 2 regulates vaccinia virus actin tail formation The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility Unique features of HIV-1 spread through T cell virological synapses Cell-fusion events induced by α-herpesviruses The virological synapse facilitates herpes simplex virus entry into T cells The immune control and cell-to-cell spread of human T-lymphotropic virus type 1 Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes Identification of host trafficking genes required for HIV-1 virological synapse formation in dendritic cells Nonlytic viral spread enhanced by autophagy components The isolation and characterization of mutants of herpes simplex virus type 1 that induce cell fusion The global phosphorylation landscape of SARS-CoV-2 infection HIV cell-to-cell spread results in earlier onset of viral gene expression by multiple infections per cell Stem cell extracellular vesicles and their potential to contribute to the repair of damaged CNS cells Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission Rapid and efficient cell-to-cell transmission of human immunodeficiency virus infection from monocyte-derived macrophages to peripheral blood lymphocytes Different requirements for scavenger receptor class B type I in hepatitis C virus cell-free versus cell-to-cell transmission Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein A viral fusogen hijacks the actin cytoskeleton to drive cell-cell fusion F-actin dynamics transform filopodial bridges into intercellular nanotubes capable of distant cell communication Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Envdependent neutralization-resistant virological synapses Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses Culturing primary and transformed neuronal cells for studying pseudorabies virus infection Hantavirus Gn and Gc envelope glycoproteins: key structural units for virus cell entry and virus assembly Varicella-zoster virus glycoprotein I is essential for growth of virus in Vero cells Membrane fusion mediated by herpesvirus glycoproteins: the paradigm of varicella-zoster virus They might be giants: does syncytium formation sink or spread HIV infection? Cell-to-cell transfer of HIV infection: implications for HIV viral persistence Actin-based motility of vaccinia virus Compartmented neuron cultures for directional infection by alpha herpesviruses A fluorescent dye is usually used to differentiate target cells from donor cells, and quantification of cell spread is determined microscopically or by flow cytometry of a reporter virus or a labeled viral antigen. keywords: actin; antibodies; cell; cell spread; cell transmission; epithelial; et al; filopodia; formation; fusion; human; infection; membrane; particles; protein; spread; target; tnts; transfer; transmission; type; virus; viruses cache: cord-317277-rr9zue4l.txt plain text: cord-317277-rr9zue4l.txt item: #418 of 549 id: cord-317533-xpfqdeqv author: Smuts, Heidi title: Human coronavirus NL63 infections in infants hospitalised with acute respiratory tract infections in South Africa date: 2008-07-24 words: 2384 flesch: 45 summary: NL63 (HCoV‐NL63) is a novel respiratory virus which is associated with respiratory tract infections in children. In this retrospective study 1055 nasopharyngeal, tracheal aspirate and bronchoalveoloar lavage samples were taken from children (age 13 days to 5 years) hospitalised with respiratory tract infections in 2003 and 2004 in the Red Cross War Memorial Children's Hospital in Cape Town. keywords: children; hcov; human; infections; nl63 cache: cord-317533-xpfqdeqv.txt plain text: cord-317533-xpfqdeqv.txt item: #419 of 549 id: cord-317988-1buh1wm0 author: Kalichman, Seth C. title: Intersecting Pandemics: Impact of SARS-CoV-2 (COVID-19) Protective Behaviors on People Living With HIV, Atlanta, Georgia date: 2020-06-05 words: 4049 flesch: 40 summary: We conducted a rapid-response interview to assess COVID-19 protective behaviors of people living with HIV and the impact of their responses on HIV-related health care. 16, 17 The increased vulnerability for COVID-19 severity in people living with HIV shines a light on the necessity of adopting COVID-19 protective behaviors, avoiding public gatherings, reducing social contacts, and physical distancing. keywords: adherence; behaviors; care; covid-19; food; health; hiv; participants; people; use cache: cord-317988-1buh1wm0.txt plain text: cord-317988-1buh1wm0.txt item: #420 of 549 id: cord-317990-61is0hgm author: Quinn, Katherine G. title: Applying the Popular Opinion Leader Intervention for HIV to COVID-19 date: 2020-06-25 words: 2199 flesch: 31 summary: Accordingly, we can take lessons learned from the HIV epidemic about the spread of public health information and its effects on behavior change apply them to the current pandemic. Stigma resulting from xenophobia or racism can limit access to accurate public health information, alienate communities from needed prevention and treatment resources, and further contribute to disparities in disease outcomes keywords: covid-19; health; hiv; men; public; social cache: cord-317990-61is0hgm.txt plain text: cord-317990-61is0hgm.txt item: #421 of 549 id: cord-318272-spt0oea0 author: Bhardwaj, Prateek title: Advancements in prophylactic and therapeutic nanovaccines date: 2020-04-05 words: 14598 flesch: 27 summary: A brief review of computer-assisted approaches to rational design of peptide vaccines Peptide vaccine: progress and challenges Principles of vaccine design-lessons from nature Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles Advances and opportunities in nanoparticle-and nanomaterial-based vaccines against bacterial infections Protein and peptide biomaterials for engineered subunit vaccines and immunotherapeutic applications Immunological mechanisms of vaccination Micro and nanoparticle-based delivery systems for vaccine immunotherapy: an immunological and materials perspective Towards tailored vaccine delivery: needs, challenges and perspectives CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery Innate and adaptive immune cells in the tumor microenvironment Trained innate immunity as underlying mechanism for the long-term, nonspecific effects of vaccines Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns Engineering nanoparticles to overcome barriers to immunotherapy Poly(lactide-co-glycolide)-rifampicin nanoparticles efficiently clear Mycobacterium bovis BCG infection in macrophages and remain membrane-bound in phago-lysosomes A therapeutic microparticle-based tumor lysate vaccine reduces spontaneous metastases in murine breast cancer Enantiospecific adjuvant activity of cationic lipid DOTAP in cancer vaccine Dendritic cell-based nanovaccines for cancer immunotherapy Adoptive immunotherapy for cancer: harnessing the T cell response Skwarczynski , Multiantigenic peptide-polymer conjugates as therapeutic vaccines against cervical cancer PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine Dendritic cells and other innate determinants of T helper cell polarisation Rosenberg , Cancer immunotherapy based on mutation-specific CD4 + T cells in a patient with epithelial cancer How regulatory T cells work Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis The cell biology of antigen processing Quantitative review of antibody response to inactivated seasonal influenza vaccines, Influenza Other Respir Single-injection vaccines: progress, challenges, and opportunities Switched memory B cells maintain specific memory independently of serum antibodies: the hepatitis B example Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype Polymeric particles in vaccine delivery Exploiting lymphatic transport and complement activation in nanoparticle vaccines Memory antibody response from antigen loaded polymer particles and the effect of antigen release kinetics Applications of nanotechnology for immunology Vaccine adjuvants: mode of action Mechanisms of action of adjuvants Toll-like receptor signaling pathways Unleashing the potential of NOD-and Toll-like agonists as vaccine adjuvants Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells Vaccine delivery using nanoparticles Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases Carbohydrate-functionalized nanovaccines preserve HIV-1 antigen stability and activate antigen presenting cells Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus Applications of nanomaterials as vaccine adjuvants Nanovaccines and their mode of action A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens Curdlan sulfate-O-linked quaternized chitosan nanoparticles: potential adjuvants to improve the immunogenicity of exogenous antigens via intranasal vaccination Green synthesis and evaluation of silver nanoparticles as adjuvant in rabies veterinary vaccine Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery Artificial bacterial biomimetic nanoparticles synergize pathogen-associated molecular patterns for vaccine efficacy Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses Intranasal nanovaccine confers homo-and hetero-subtypic influenza protection Encapsulins: microbial nanocompartments with applications in biomedicine, nanobiotechnology and materials science Biomimetic protein nanoparticles facilitate enhanced dendritic cell activation and cross-presentation Vault particles: a new generation of delivery nanodevices A protective vaccine against chlamydia genital infection using vault nanoparticles without an added adjuvant A supramolecular vaccine platform based on alpha-helical peptide nanofibers Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope Nanoscale peptide self-assemblies boost BCG-primed cellular immunity against mycobacterium tuberculosis Titrating T-cell epitopes within self-assembled vaccines optimizes CD4 + helper T cell and antibody outputs Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8( + ) T cell-dependent anti-tumor immunity in mice De Berardinis , Vectorized delivery of alpha-galactosylceramide and tumor antigen on filamentous bacteriophage fd induces protective immunity by enhancing tumor-specific T Cell response Targeting mutated plus germline epitopes confers pre-clinical efficacy of an instantly formulated cancer nano-vaccine Heat shock protein-peptide and HSP-based immunotherapies for the treatment of cancer Pre-clinical development of Listeria-based nanovaccines as immunotherapies for solid tumours: insights from melanoma Antitumor humoral and T Cell responses by Mucin-1 conjugates of bacteriophage Qbeta in wild-type mice Intradermal delivery of vaccine nanoparticles using hollow microneedle array generates enhanced and balanced immune response Effect of TLR ligands co-encapsulated with multiepitopic antigen in nanoliposomes targeted to human DCs via Fc receptor for cancer vaccines Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8( + ) keywords: activation; adjuvants; antibody; antigen; cancer; cd8; cells; delivery; hiv; immune; immunity; immunization; influenza; malaria; membrane; memory; mice; nanoparticles; nanovaccines; peptide; potential; prophylactic; protein; responses; surface; therapeutic; tumor; vaccine; virus cache: cord-318272-spt0oea0.txt plain text: cord-318272-spt0oea0.txt item: #422 of 549 id: cord-318363-1mv5j4w2 author: Zvolensky, Michael J. title: Psychological, addictive, and health behavior implications of the COVID-19 pandemic date: 2020-08-27 words: 15844 flesch: 26 summary: Although many of these relations would be expected, theoretically, to be negative, select subgroups will certainly adaptively respond to COVID-19 related stress (e.g., improve their physical fitness, improve self-care routines, quit/reduce maladaptive behaviors that place them at risk). Although this illustrative example represents only one of many possible transdiagnostic amplifying factors, it draws attention to the fact that individual differences in psychological processes are apt to play a central role in the relation between COVID-19 related stress and mental health, addictive behavior, health behavior, and chronic illness. keywords: alcohol; anxiety; behavior; cannabis; children; chronic; covid-19; covid-19 pandemic; disease; et al; factors; health; health behavior; hiv; illness; individuals; j o; pandemic; psychological; r n; risk; sleep; smoking; stress; symptoms; treatment; u r; use cache: cord-318363-1mv5j4w2.txt plain text: cord-318363-1mv5j4w2.txt item: #423 of 549 id: cord-318570-wj7r6953 author: Xiao, Yinzong title: Point-of-Care Tests for Hepatitis B: An Overview date: 2020-10-02 words: 8334 flesch: 33 summary: Am Evaluation of a New Hepatitis B Virus Surface Antigen Rapid Test with Improved Sensitivity Evaluation of the performance of four rapid tests for detection of hepatitis B surface antigen in Antananarivo, Madagascar Hepatitis B Surface Antigen Seroprevalence among Prevaccine and Vaccine Era Children in Bangladesh Evaluation of Four Rapid Tests for Detection of Hepatitis B Surface Antigen in Ivory Coast Prevalence of infection with hepatitis B and C virus and coinfection with HIV in medical inpatients in Malawi Detection of Highly Prevalent Hepatitis B Virus Coinfection among HIV-Seropositive Persons in Ghana Reliability of rapid testing for hepatitis B in a region of high HIV endemicity Viral Hepatitis and Rapid Diagnostic Test Based Screening for HBsAg in HIV-infected Patients in Rural Tanzania Prevalence and associations with hepatitis B and hepatitis C infection among HIV-infected adults in South Africa Field performance of the Determine HBsAg point-of-care test for diagnosis of hepatitis B virus co-infection among HIV patients in Zambia Occult hepatitis B and HIV infection HIV-hepatitis B virus coinfection Prevalence of chronic hepatitis B virus infection before and after implementation of a hepatitis B vaccination program among children in Nepal Point of care and oral fluid hepatitis B testing in remote Indigenous communities of northern Australia Evaluation of the analytical performance of six rapid diagnostic tests for the detection of viral hepatitis B and C in Lubumbashi, Democratic Republic of Congo Performance of point of care assays for hepatitis B and C viruses in chronic kidney disease patients Evaluating HBsAg rapid test performance for different biological samples from low and high infection rate settings & populations Hepatitis B virus sero-prevalence amongst pregnant women in the Gambia Seroprevalence of HBV among people living with HIV in Anyigba Assessment of hepatitis B immunization programme among school students in Qatar Seroprevalence of hepatitis B virus infection and associated factors among healthcare workers in northern Tanzania Seroprevalence of hepatitis B and C virus infections among diabetic patients in Kisangani (North-eastern Democratic Republic of Congo) Eligibility for hepatitis B antiviral therapy among adults in the general population in Zambia Maternal Hepatitis B Infection Burden, Comorbidity and Pregnancy Outcome in a Low-Income Population on the Myanmar-Thailand Border: A Retrospective Cohort Study The prevalence of hepatitis B virus among HIV-positive patients at Kilimanjaro Christian Medical Centre Referral Hospital Sero-prevalence of HBV and associated risk factors among HIV positive individuals attending ART clinic at Mekelle hospital Hepatitis B Infection, Viral Load and Resistance in HIV-Infected Patients in Mozambique and Zambia palliduminfections among blood donors and Transfusion-related complications among recipients at the Laquintinie hospital in Douala Prevalence of hepatitis B and hepatitis C infection from a population-based study in Southern India Prevalence estimates of HIV, syphilis, hepatitis B and C among female sex workers (FSW) in Brazil Simultaneous Human Immunodeficiency Virus-Hepatitis B-Hepatitis C Point-of-Care Tests Improve Outcomes in Linkage-to-Care: Results of a Randomized Control Trial in Persons Without Healthcare Coverage. Potential Application in Young Children and Infants Evaluation of the Performance of Two Rapid Immunochromatographic Tests for Detection of Hepatitis B Surface Antigen and Anti HCV Antibodies Using Elisa Tested Samples Sensitivity and specificity of commercially available rapid diagnostic tests for viral hepatitis B and C screening in serum samples Evaluation of performance testing of different rapid diagnostic kits in comparison with EIAs to validate detection of hepatitis B virus among high risk group in Nigeria Multi-Disease Diagnostics Landscape for Integrated Management of HIV, HCV, TB and Other Coinfections Analytical performances of simultaneous detection of HIV-1, HIV-2 and hepatitis Cspecific antibodies and hepatitis B surface antigen (HBsAg) by multiplex immunochromatographic rapid test with serum samples: A cross-sectional study Performance evaluation of 70 hepatitis B virus (HBV) surface antigen (HBsAg) assays from around the world by a geographically diverse panel with an array of HBV genotypes and HBsAg subtypes Comparative Performance of Three Rapid HBsAg Assays for Detection of HBs Diagnostic Escape Mutants in Clinical Samples: TABLE 1 Point-of-care screening for hepatitis B virus infection in pregnant women at an antenatal clinic: A South African experience A guide to aid the selection of diagnostic tests Evaluation of Rapid Diagnostic Tests for Assessment of Hepatitis B in Resource-Limited Settings Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: Implications for field studies Performance of rapid diagnostic tests for the detection of anti-HBs in various patient populations Performance of the Xpert HBV Viral Load assay versus the Aptima Quant assay for quantifying hepatitis B virus DNA Evaluation of the Xpert HBV Viral Load for hepatitis B virus molecular testing Rapid, random-access, quantification of hepatitis B virus using the Cepheid Xpert®HBV Viral Load assay Prevention of materno-foetal transmission of hepatitis B in sub-Saharan Africa: keywords: blood; care; cost; hbsag; hbv; hepatitis; hiv; infection; people; pocs; resource; screening; settings; testing; tests; treatment; virus cache: cord-318570-wj7r6953.txt plain text: cord-318570-wj7r6953.txt item: #424 of 549 id: cord-318587-ewvnkdr2 author: Steeds, Kimberley title: Pseudotyping of VSV with Ebola virus glycoprotein is superior to HIV-1 for the assessment of neutralising antibodies date: 2020-08-31 words: 4989 flesch: 35 summary: Pseudotyped virus neutralisation assay raw data were normalised as percentage (%) infection relative to mean values for pseudotyped virus only controls (equivalent to 100% infection), then IC 50 of pseudotyped virus neutralisation were estimated by model of nonlinear regression fit with settings for log (inhibitor) vs. normalised response curves using GraphPad Prism v5 (San Diego, California (CA), USA). A number of EBOV GP pseudotyped virus neutralisation assays have been developed to investigate immune responses to EBOV infection and vaccination [16] [17] [18] , as well as for evaluation of monoclonal antibody (mAb) therapies [19] keywords: assay; cells; ebola; ebov; neutralisation; plasma; pseudotyped; virus; viruses; vsv cache: cord-318587-ewvnkdr2.txt plain text: cord-318587-ewvnkdr2.txt item: #425 of 549 id: cord-318591-ssnlfjap author: Pecego, AC title: Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV date: 2020-01-22 words: 4444 flesch: 42 summary: Those with symptom onset greater than 10 days but up to 30 days prior were considered as non-SARI patients ( Figure 1 ). According to SARI classification, we saw that clinical and epidemiological characteristics were evenly distributed with no statistical difference between SARI and non-SARI patients, except for mortality rate, which was significantly more prevalent among non-SARI patients (Table 1) . keywords: days; hiv; infection; influenza; non; patients; plwh; pneumonia; sari; study cache: cord-318591-ssnlfjap.txt plain text: cord-318591-ssnlfjap.txt item: #426 of 549 id: cord-319002-xmsfkaoc author: Brown, James title: Community-Acquired Pneumonia in HIV-Infected Individuals date: 2014-02-22 words: 5673 flesch: 30 summary: Calverton: ICF International Analysis from the THIN database of primary care records comparing records of 939 cases of HIV infection with 2576 controls demonstrating importance of HIV Invasive pneumococcal disease among HIV-positive individuals Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity Bronchoalveolar CD4+ T cell responses to respiratory antigens are impaired in HIV-infected adults Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults Dendritic cell dysregulation during HIV-1 infection CD4-and dynamin-dependent endocytosis of HIV-1 into plasmacytoid dendritic cells CD8+ T cells and risk for bacterial pneumonia and all-cause mortality among HIV-infected women Oral and airway microbiota in HIV-infected pneumonia patients Invasive pneumococcal disease in patients infected with HIV: still a threat in the era of highly active antiretroviral therapy Impact of human immunodeficiency virus infection on Streptococcus pneumoniae colonization and seroepidemiology among Zambian women Streptococcus pneumoniae colonization among patients with human immunodeficiency virus-1 who had received 23-valent polysaccharide pneumococcal vaccine Risk factors for pneumococcal nasopharyngeal colonization before and after pneumococcal conjugate vaccination in persons with HIV: brief report HIV and influenza virus infections are associated with increased blood pneumococcal load: a prospective, hospital-based observational study in South Africa Viral pathogens including human metapneumovirus are the primary cause of febrile respiratory illness in HIV-infected adults receiving antiretroviral therapy Respiratory syncytial virus (RSV) community-acquired pneumonia (CAP) in a hospitalized adult with human immunodeficiency virus (HIV) mimicking influenza A and Pneumocystis (carinii) key: cord-319002-xmsfkaoc authors: Brown, James; Lipman, Marc title: Community-Acquired Pneumonia in HIV-Infected Individuals date: 2014-02-22 journal: Curr Infect Dis Rep DOI: 10.1007/s11908-014-0397-x sha: doc_id: 319002 cord_uid: xmsfkaoc Community-acquired pneumonia continues to be an important complication of HIV infection. keywords: art; cd4; disease; hiv; individuals; influenza; patients; pneumonia; risk; study cache: cord-319002-xmsfkaoc.txt plain text: cord-319002-xmsfkaoc.txt item: #427 of 549 id: cord-319043-hczwgf6o author: Ashkenazi, Avraham title: Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1 date: 2012-08-07 words: 5713 flesch: 43 summary: hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release West Nile virus entry requires cholesterol-rich membrane microdomains and is independent of ␣v␤3 integrin The HIV lipidome: a raft with an unusual composition Functional rafts in cell membranes Revitalizing membrane rafts: new tools and insights Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease Mechanisms of viral membrane fusion and its inhibition The HIV Env-mediated fusion reaction The function of coreceptor as a basis for the kinetic dissection of HIV type 1 envelope protein-mediated cell fusion Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions HIV-1 inhibition by a peptide Capture of an early fusion-active conformation of HIV-1 gp41 HIV entry and its inhibition Membrane-anchored inhibitory peptides capture human immunodeficiency virus type 1 gp41 conformations that engage the target membrane prior to fusion Dilation of the human immunodeficiency virus-1 envelope glycoprotein fusion pore revealed by the inhibitory action of a synthetic peptide from gp41 The structural biology of type I viral membrane fusion Core structure of gp41 from the HIV envelope glycoprotein Atomic structure of the ectodomain from HIV-1 gp41 Intracellular and viral membrane fusion: a uniting mechanism Biophysics of sphingolipids I. Membrane properties of sphingosine, ceramides and other simple sphingolipids The ins and outs of sphingolipid synthesis Synthesis of the antibacterial peptide cecropin A (1-33) Virus-cell and cell-cell fusion mediated by the HIV-1 envelope glycoprotein is inhibited by short gp41 N-terminal membrane-anchored peptides lacking the critical pocket domain Site-specific mutations in HIV-1 gp41 reveal a correlation between HIV-1-mediated bystander apoptosis and fusion/hemifusion Fatty acids can substitute the HIV fusion peptide in lipid merging and fusion: an analogy between viral and palmitoylated eukaryotic fusion proteins Androctonin, a hydrophilic disulphide-bridged nonhaemolytic anti-microbial peptide: a plausible mode of action Spectroscopic and functional characterization of the putative transmembrane segment of the minK potassium channel Amino acid conservation in the gp41 transmembrane protein and natural polymorphisms associated with enfuvirtide resistance across HIV-1 variants Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target Membrane-anchored HIV-1 N-heptad repeat peptides are highly potent cell fusion inhibitors via an altered mode of action Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region Design of a novel peptide inhibitor of HIV fusion that disrupts the internal trimeric coiled-coil of gp41 Emergence of a drugdependent human immunodeficiency virus type 1 variant during therapy with the T20 fusion inhibitor Demonstrating the C-terminal boundary of the HIV 1 fusion conformation in a dynamic ongoing fusion process and implication for fusion inhibition Different from the HIV fusion inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120 Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1 Sphingolipids: modulators of HIV-1 infection and pathogenesis Model for HIV membrane fusion and the structure of lipids investigated in this study. keywords: activity; cells; cholesterol; fig; fusion; gp41; hiv; lipid; membrane; n17; peptides; sphinganine; sphingopeptides; virus cache: cord-319043-hczwgf6o.txt plain text: cord-319043-hczwgf6o.txt item: #428 of 549 id: cord-319116-2ts6zpdb author: Ruggiero, Emanuela title: G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy date: 2018-04-20 words: 9174 flesch: 33 summary: Mass spectrometry competition analysis revealed a stronger preference for HIV-1 G4s over HSV-1, but generally, viral G4s were preferentially bound, when compared to the telomeric G4. Since c-exNDI selectivity towards HSV-1 G4s in vitro resulted to be good but not outstanding, the marked anti-HSV-1 activity was likely due also to the massive presence of viral G4s in the cell nucleus, which was demonstrated to occur during HSV-1 replication (70) . keywords: activity; binding; cell; dna; g4s; genome; human; ligands; ltr; quadruplex; replication; rna; sequences; structures; telomerase; virus; viruses cache: cord-319116-2ts6zpdb.txt plain text: cord-319116-2ts6zpdb.txt item: #429 of 549 id: cord-319263-g49jma8n author: Marziali, Megan E. title: Physical Distancing in COVID-19 May Exacerbate Experiences of Social Isolation among People Living with HIV date: 2020-04-23 words: 1290 flesch: 39 summary: It is thus likely that rates of social isolation and loneliness will increase dramatically during the COVID-19 outbreak. Social isolation, or disconnectedness at the individual level, can be quantified objectively by measuring level of engagement with peers [7, 8] . keywords: health; hiv; isolation; loneliness cache: cord-319263-g49jma8n.txt plain text: cord-319263-g49jma8n.txt item: #430 of 549 id: cord-319354-jbain7n6 author: Gondim, Ana C. S. title: Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity date: 2019-01-14 words: 4072 flesch: 49 summary: The best-studied cases of lectins with potent antiviral (i.e. HIV) activity have been the cyanobacterial cyanovirin N algal lectin and the red algal lectin griffithsin, which have picomolar potency against HIV-1. These results indicate that leguminous lectins most likely block the adsorption/entry of the virus in the infection step, presumably by binding to the heavily glycosylated gp120/gp41 that is expressed on persistently HIV-1-infected HUT78/HIV1 cells. keywords: activity; binding; cells; dsclerl; gp120; hiv; influenza; lectins; surface; virus cache: cord-319354-jbain7n6.txt plain text: cord-319354-jbain7n6.txt item: #431 of 549 id: cord-319609-y0gdjn64 author: Van Duyne, Rachel title: The identification of unique serum proteins of HIV-1 latently infected long-term non-progressor patients date: 2010-07-06 words: 8561 flesch: 42 summary: The utilization of proteomic techniques to globally identify differentially expressed serum proteins in response to HIV-1 infection is a significant undertaking that is complicated due to the innate protein profile of human serum. These findings also indicate a difference in composition of serum proteins present in HIV-1 infected individuals undergoing HAART treatment versus those that are naturally non-progressing. keywords: abundance; cell; figure; gst; haart; infected; infection; ink4a; low; ltnp; p16; patient; presence; proteins; samples; serum; treatment cache: cord-319609-y0gdjn64.txt plain text: cord-319609-y0gdjn64.txt item: #432 of 549 id: cord-320116-63yvpuqx author: Bancroft, Tara title: Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes date: 2019-10-07 words: 11945 flesch: 39 summary: Although mutated bNAbs are capable of broad Env recognition and virus neutralization, most inferred germline bNAb variants do not display reactivity with any Env variant tested, which led us and others to propose that one reason for the lack of bNAb elicitation through immunization is the lack of stimulation of B cells expressing bNAb progenitor B cell receptors (BCRs) by Env-based immunogens (Xiao et al., 2009; Hoot et al., 2013; Jardine et al., 2013; McGuire et al., 2013; Andrabi et al., 2015; Zhou et al., 2015; Gorman et al., 2016) . Env-based immunogens capable of binding to certain germline bNAbs have been recently developed that effectively activate B cells in knock-in mice expressing the desired BCRs in vivo (Dosenovic et al., 2015; Escolano et al., 2016; Jardine et al., 2016; McGuire et al., 2016; Steichen et al., 2016; Abbott et al., 2018) . keywords: anti; antibodies; antibody; apc; b cells; bcrs; binding; cells; chain; control; et al; fig; heavy; human; ib2; ib3; iglb12; light; mice; transgenic cache: cord-320116-63yvpuqx.txt plain text: cord-320116-63yvpuqx.txt item: #433 of 549 id: cord-320156-xs936r6u author: Nunes, Marta C. title: Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children date: 2014-10-28 words: 3694 flesch: 38 summary: Although our study was not designed to establish whether polyomavirus infections caused more severe disease in HIV-infected children, among hospitalized children in whom polyomaviruses were detected HIV-infected were more likely to present with pneumonia rather than bronchiolitis, had a longer duration of hospitalization and higher CFR compared to HIV-uninfected children. key: cord-320156-xs936r6u authors: Nunes, Marta C.; Kuschner, Zachary; Rabede, Zelda; Cutland, Clare L.; Madimabe, Richard; Kuwanda, Locadiah; Klugman, Keith P.; Adrian, Peter V.; Madhi, Shabir A. title: Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children date: 2014-10-28 journal: J Clin Virol DOI: 10.1016/j.jcv.2014.10.013 sha: doc_id: 320156 cord_uid: xs936r6u BACKGROUND: Two recently discovered polyomaviruses (PyV), WU and KI, have been identified in respiratory-tract specimens from children with acute respiratory infections, although there are limited data in HIV-infected children. keywords: children; hiv; kipyv; lrtis; pneumonia; respiratory; wupyv cache: cord-320156-xs936r6u.txt plain text: cord-320156-xs936r6u.txt item: #434 of 549 id: cord-320832-q1oojklw author: Hanum, Nadia title: Use of HIV pre-exposure prophylaxis among men who have sex with men in England: data from the AURAH2 prospective study date: 2020-09-01 words: 6009 flesch: 51 summary: Although in our study we found no significant association between anxiety or depression and reporting recent PrEP use or PrEP, in a 2020 Australian study, PrEP use was independently associated with lower levels of HIV-related anxiety among PrEP-eligible men (MSM at high risk of HIV infection) than among PrEP ineligible men (MSM at low risk). Overall, PrEP use in the past year increased from 0% (none of 28 respondents) in July to December, 2013, to 43% (23 of 53) in January to March, 2018. keywords: baseline; data; hiv; men; msm; prep; sex; study; use cache: cord-320832-q1oojklw.txt plain text: cord-320832-q1oojklw.txt item: #435 of 549 id: cord-321773-5fw9abzl author: Cheng, Wenyu title: DDX5 RNA Helicases: Emerging Roles in Viral Infection date: 2018-04-09 words: 6757 flesch: 42 summary: DDX5 binds to the viral 3 -UTR and colocalize with viral RNA, which promotes virus RNA replication but not in viral protein translation. By exploiting the driving force of DDX5-mediated ATP hydrolysis or assembling large ribonucleoprotein complexes, RNA viruses can complete their life cycles. keywords: box; cells; ddx5; function; hcv; helicase; hepatitis; host; human; infection; proteins; replication; rev; rna; transcription; virus cache: cord-321773-5fw9abzl.txt plain text: cord-321773-5fw9abzl.txt item: #436 of 549 id: cord-322256-mv9ll0h4 author: Edelman, E. Jennifer title: Confronting Another Pandemic: Lessons from HIV can Inform Our COVID-19 Response date: 2020-05-12 words: 1750 flesch: 33 summary: Further, COVID-19 care can be informed by extensive efforts that have been applied to enhance retention in lifelong HIV care and outreach efforts to identify and connect with patients vulnerable to effects of social isolation, worsening mental health, substance use, and intimate partner violence. With both HIV and COVID-19, the risk of occupational exposure and the safety of health care workers has been a paramount concern. keywords: care; covid-19; health; hiv cache: cord-322256-mv9ll0h4.txt plain text: cord-322256-mv9ll0h4.txt item: #437 of 549 id: cord-322503-fynprt6f author: Thakur, Aarzoo title: Physiologically‐Based Pharmacokinetic Modeling to Predict the Clinical Efficacy of the Coadministration of Lopinavir and Ritonavir against SARS‐CoV‐2 date: 2020-08-07 words: 3536 flesch: 38 summary: The concentration-time profiles along with EC 50,unbound values are shown in Figure 1D and E. The f u,media for lopinavir in 2% FCS was determined to be 0.355, which yielded an EC 50,unbound value of 0.386 µg/mL and EC 90,unbound value of 0.806 µg/mL against SARS-CoV-2 from Ohashi et al., 17 while the corresponding f u,media in 5% FCS was reported by Hickman et al. as 0.200, which yielded an EC 50,unbound value of 0.721 µg/mL from Yamamoto et al. 16 Using the same dosing regimen, a comparison of the C u,lung with both EC 50,unbound and EC 90,unbound values of lopinavir against SARS-CoV-2 showed that insufficient unbound lopinavir concentrations were achieved in lung tissue for both Caucasian (unbound lung C max = 0.130 µg/mL) and Chinese populations (unbound lung C max = 0.200 µg/mL) (Figure 2A and B). We developed a physiologically-based pharmacokinetic (PBPK) model to predict unbound lung tissue concentrations of lopinavir when co-administered with ritonavir. keywords: concentrations; copyright; lopinavir; lung; ritonavir; sars; unbound cache: cord-322503-fynprt6f.txt plain text: cord-322503-fynprt6f.txt item: #438 of 549 id: cord-322581-v96k4yxg author: Mockiene, Vida title: Nurses' willingness to take care of people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) — does a teaching intervention make a difference? date: 2011-08-31 words: 4351 flesch: 51 summary: However, little research has focused on adapting the education interventions to target new behaviours associated with HIV, such as increasing nurses' engagement in HIV health care and supportive services. It is therefore important to focus on improving nurse education, and basic educational support should be a priority for those working with PLHIV. keywords: care; group; hiv; intervention; nurses; plhiv; willingness cache: cord-322581-v96k4yxg.txt plain text: cord-322581-v96k4yxg.txt item: #439 of 549 id: cord-322915-zrjx31ev author: Demain, Arnold L title: Microbial drug discovery: 80 years of progress date: 2009-01-09 words: 11264 flesch: 36 summary: Furthermore, reports have been published on natural product inhibitors of HIV integrase obtained from among the marine ascidian alkaloids; that is, the lamellarins (produced by the mollusk Lamellaria sp.), and from terrestrial plants (Baccharis genistelloides and Achyrocline satureioides). The FAM (5-fluorouracil, adriamycin, mitomycin C) and SMF (streptozotocin, mitomycin C, 5-fluorouracil) chemotherapy regimens Mitomycin dimers: polyfunctional cross-linkers of DNA Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice Improved production of pentostatin and identification of fermentation cometabolites Pentostatin in T-non-Hodgkin's lymphomas: efficacy and effect on CD26+ T lymphocytes Cleavage behavior of calicheamicin gamma 1 and calicheamicin T Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia Study on the preparation and regeneration of protoplast from taxol-producing fungus Nodulisporium sylviforme Natural products as sources of new drugs over the last 25 years Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria): production, physico-chemical and biological properties Epothilones, a new class of microtubulestabilizing agents with a taxol-like mechanism of action Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol) keywords: acid; activity; agents; antibiotics; bacteria; cancer; cell; compounds; development; discovery; disease; drugs; gram; growth; health; hiv; human; infections; inhibitors; microbial; patients; production; products; resistance; streptomyces; treatment; use; years cache: cord-322915-zrjx31ev.txt plain text: cord-322915-zrjx31ev.txt item: #440 of 549 id: cord-323261-1of5ertf author: Lo, Catherine Yuk-ping title: Securitizing HIV/AIDS: a game changer in state-societal relations in China? date: 2018-05-16 words: 9434 flesch: 43 summary: The body China AIDS Fund For Non-Governmental Organizations Making Turkey's transformation possible: claiming securityspeak-not Desecuritization! Having said that the Chinese government realized the impacts health problems or infectious diseases could have on its economic and social development, the previous work cannot explain why a high degree of political recognition was observed solely in HIV/ AIDS NGOs, instead of other health NGOs, such as TB or cancer NGOs in China. keywords: aids; aids securitization; china; chinese; fund; global; government; grassroots; health; hiv; hiv/ aids; national; ngos; securitization; security; society; state cache: cord-323261-1of5ertf.txt plain text: cord-323261-1of5ertf.txt item: #441 of 549 id: cord-324034-6cmztvyf author: Ashare, Rebecca L title: The United States National Cancer Institute’s Coordinated Research Effort on Tobacco Use as a Major Cause of Morbidity and Mortality among People with HIV date: 2020-08-17 words: 1667 flesch: 41 summary: In this Commentary, we describe a United States National Cancer Institute (NCI)-led initiative to address the relative lack of research focused on developing, testing, and implementing smoking cessation interventions for PWH. 3 Physical distancing recommendations have made identifying creative strategies for delivering smoking cessation interventions without face-to-face interactions a priority. keywords: hiv; pwh; smoking cache: cord-324034-6cmztvyf.txt plain text: cord-324034-6cmztvyf.txt item: #442 of 549 id: cord-324056-cvvyf3cb author: Kelley, Patrick W. title: Global Health: Governance and Policy Development date: 2011-06-30 words: 5955 flesch: 43 summary: It describes the massive increases in bilateral and multilateral investments in global health and it highlights the current global and US architecture for performing global health programs. Few other actors were engaged in global health. keywords: aids; countries; development; diseases; global; governance; health; hiv; international; malaria; new; organization; policy; world cache: cord-324056-cvvyf3cb.txt plain text: cord-324056-cvvyf3cb.txt item: #443 of 549 id: cord-324137-nau83mjv author: Saranathan, Nandhini title: G-Quadruplexes: More Than Just a Kink in Microbial Genomes date: 2018-09-14 words: 6751 flesch: 38 summary: An earlier study reports that, following concatemeric replication of HHV-1, the cleavage of unit length genomes and their encapsidation is achieved by the binding of virus proteins to a DNA secondary structure formed by a DNA packaging sequence (pac-1) Taken together, these results suggest that G4s in virus genomes may interact with host proteins not only to facilitate virus latency but also to revoke viruses from latency. keywords: binding; dna; g4s; gene; genome; host; motifs; promoter; proteins; quadruplex; recombination; replication; rna; structures; transcription; virus cache: cord-324137-nau83mjv.txt plain text: cord-324137-nau83mjv.txt item: #444 of 549 id: cord-324690-82qsirnk author: Dieffenbach, Carl W title: The search for an HIV vaccine, the journey continues date: 2020-05-16 words: 1470 flesch: 42 summary: As we reflect upon the status of HIV vaccine research, we would be remiss if we did not mention the current global pandemic caused by SARS-CoV-2. The authors thank the trial participants, community members, activists and researchers who have so willingly participated in the challenging work of HIV vaccine discovery and development. keywords: hiv; rv144; studies; trial; vaccine cache: cord-324690-82qsirnk.txt plain text: cord-324690-82qsirnk.txt item: #445 of 549 id: cord-324829-0nz0qioh author: Carabineiro, Sónia Alexandra Correia title: Applications of Gold Nanoparticles in Nanomedicine: Recent Advances in Vaccines † date: 2017-05-22 words: 7662 flesch: 32 summary: Recent advances toward clinical applications Polymeric nanoparticles Potent vectors for vaccine delivery targeting cancer and infectious diseases Tracking Targeted Bimodal Nanovaccines: Immune Responses and Routing in Cells, Tissue, and Whole Organism Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine Synthesis of tumor-associated MUC1-glycopeptides and their multivalent presentation by functionalized gold colloids Metal Based Frameworks for Drug Delivery Systems Gold Nanoparticles: Recent Advances in the Biomedical Applications Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months Assessment of gold nanoparticles as a size-dependent vaccine carrier for enhancing the antibody response against synthetic foot-and-mouth disease virus peptide Structure function attributes of gold nanoparticle vaccine association: Effect of particle size and association temperature Intracellular accumulation and immunological properties of fluorescent gold nanoclusters in human dendritic cells Different-Sized Gold Nanoparticle Activator/Antigen Increases Dendritic Cells Accumulation in Liver-Draining Lymph Nodes and CD8+T Cell Responses Yeast-Expressed Bacteriophage-Like Particles for the Packaging of Nanomaterials Polyelectrolyte Multilayers Assembled Entirely from Immune Signals on Gold Nanoparticle Templates Promote Antigen-Specific T Cell Response Impact of dose, route, and composition on the immunogenicity of immune polyelectrolyte multilayers delivered on gold templates Construction and Immunological Evaluation of CpG-Au@HBc Virus-Like Nanoparticles as a Potential Vaccine Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice Engineered CpG-Antigen Conjugates Protected Gold Nanoclusters as Smart Self-Vaccines for Enhanced Immune Response and Cell Imaging Endotoxin Nanovesicles: Hydrophilic Gold Nanodots Control Supramolecular Lipopolysaccharide Assembly for Modulating Immunological Responses Epidermal powder immunization induces both cytotoxic T-lymphocyte and antibody responses to protein antigens of influenza and hepatitis B viruses Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermis Recent advances in Hepatitis B vaccination Nanoparticulate mediated transcutaneous immunization: Myth or reality A Solid-in-Oil Dispersion of Gold Nanorods Can Enhance Transdermal Protein Delivery and Skin Vaccination A microarray MEMS device for biolistic delivery of vaccine and drug powders Cancer: Gold nanoparticles were coated with the F1-antigen of Yersinia pestis (bacterium responsible for the plague), using N-hydroxysuccinimide and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide A recent study showed that animals immunized with a transmissible gastroenteritis virus, conjugated with colloidal gold nanoparticles, produced antibodies with a higher titer than those produced in response to the native virus keywords: adjuvant; antigen; cancer; cells; delivery; gold; hiv; mice; nanoparticles; peptide; protein; response; tumor; vaccine; virus cache: cord-324829-0nz0qioh.txt plain text: cord-324829-0nz0qioh.txt item: #446 of 549 id: cord-324984-ojrpsdt9 author: Ji, Xingyue title: Medicinal chemistry strategies toward host targeting antiviral agents date: 2020-02-14 words: 16870 flesch: 33 summary: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus Molecular chaperone Hsp90 is a therapeutic target for noroviruses Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers Hsp90, an unlikely ally in the war on cancer Geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro Inhibition of heat-shock protein 90 reduces Ebola virus replication Heat shock protein 90 controls HIV-1 reactivation from latency Hsp90 inhibitors reduce influenza virus replication in cell culture Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance A novel class of geldanamycin derivatives as HCV replication inhibitors targeting on Hsp90: synthesis, structure-activity relationships and anti-HCV activity in GS4.3 replicon cells Synthesis and biological evaluation of heat-shock protein 90 inhibitors: geldanamycin derivatives with broad antiviral activities Hsp90 inhibitor AT-533 blocks HSV-1 nuclear egress and assembly Inhibition of heat-shock protein 90 reduces Ebola virus replication Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro Hsp90 molecular chaperone inhibitors: are we there yet? but not in patients in a randomized clinical trial Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90 Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits Geldanamycin, a potent and specific inhibitor of Hsp90, inhibits gene expression and replication of human cytomegalovirus Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: keywords: activity; antiviral; compound; cxcr4; development; drug; effects; hbv; hcv; hepatitis; hiv-1; host; hsp90; human; inhibition; inhibitors; kinase; patients; potent; protein; replication; rna; spectrum; targeting; treatment; trial; virus; viruses; vitro cache: cord-324984-ojrpsdt9.txt plain text: cord-324984-ojrpsdt9.txt item: #447 of 549 id: cord-325300-wawui0fd author: Tulchinsky, Theodore H. title: 4 Communicable Diseases date: 2000-12-31 words: 31283 flesch: 46 summary: EIS officers are assigned to state health departments, other public health units, and research centers as part of their training, carrying out epidemic investigation and special tasks in disease control. In disease control, individual immunity may also protect another individual. keywords: acute; animals; areas; blood; care; cases; cause; children; contact; control; countries; coverage; deaths; disease; disease control; epidemic; eradication; fever; food; health; hiv; immunization; infection; malaria; new; organism; persons; population; potential; prevention; program; public; risk; spread; states; transmission; treatment; united; vaccination; vaccine; vector; virus; water; world; year cache: cord-325300-wawui0fd.txt plain text: cord-325300-wawui0fd.txt item: #448 of 549 id: cord-325936-rwxg187r author: Eyal, Nir title: AIDS Activism and Coronavirus Vaccine Challenge Trials date: 2020-06-26 words: 2221 flesch: 43 summary: Challenge trials will also need to wait SARS-CoV-2 culture and viral dose confirmation. Alluding to people who have declared their initial interest on a website in participating in challenge trials (nearly 27,000 so far), [22] the AVAC and TAG Statement adds, we do not believe that individuals' expressed willingness to participate in such a trial is an adequate or appropriate measure of informed consent [2] . keywords: challenge; hiv; risk; sars; trials cache: cord-325936-rwxg187r.txt plain text: cord-325936-rwxg187r.txt item: #449 of 549 id: cord-326558-6tss9ydx author: Chen, Jiao title: A binning tool to reconstruct viral haplotypes from assembled contigs date: 2019-11-04 words: 6712 flesch: 52 summary: In addition, instead of assuming any parametric distribution, which is usually not the case for haplotype contigs, we will use a non-parametric distribution. Note that the common regions between different haplotypes are regarded as different positions and thus should be covered by different contigs. keywords: abundance; binning; clustering; contigs; data; haplotypes; number; sets; sub; virbin cache: cord-326558-6tss9ydx.txt plain text: cord-326558-6tss9ydx.txt item: #450 of 549 id: cord-326642-kc85pev4 author: Cohen, Adam L. title: Parainfluenza Virus Infection Among Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Children and Adults Hospitalized for Severe Acute Respiratory Illness in South Africa, 2009–2014 date: 2015-09-19 words: 4063 flesch: 45 summary: A preliminary study of pneumonia etiology among hospitalized children in Kenya Severe influenza-associated lower respiratory tract infection in a high HIV-prevalence setting-South Africa Severe lower respiratory tract infections associated with human parainfluenza viruses 1-3 in children infected and non-infected with HIV type 1 An investigation into the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections in Cape Town, South Africa Respiratory viral coinfections identified by a 10-plex real-time reverse-transcription polymerase chain reaction assay in patients hospitalized with severe acute respiratory illness-South Africa Epidemiology of severe acute respiratory illness among adults and children aged ≥5 years in a high HIV-prevalence setting Epidemiology of viral-associated acute lower respiratory tract infection among children <5 years of age in a high HIV prevalence setting Evaluation and improvement of real-time PCR assays targeting lytA, ply, and psaA genes for detection of pneumococcal DNA Population-based incidence of severe acute respiratory virus infections among children aged <5 years in rural Bangladesh Viral etiologies of hospitalized acute lower respiratory infection patients in China Hospitalization due to human parainfluenza virus-associated lower respiratory tract illness in rural Thailand Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus Incidence and etiology of acute lower respiratory tract infections in hospitalized children younger than 5 years in rural Thailand Interaction between influenza virus and Streptococcus pneumoniae in severe pneumonia Association between respiratory syncytial virus activity and pneumococcal disease in infants: a time series analysis of US hospitalization data Seasonal trends of human parainfluenza viral infections: United States Viral etiology of influenza-like illnesses in Cameroon Progress in the development of human parainfluenza virus vaccines In our second analysis, univariate and multivariable logistic regression was used to determine factors associated with HIV infection among patients with PIV-associated SARI from January 2009 to December 2014 at all SARI sites. keywords: age; children; hiv; piv; sari; type; years cache: cord-326642-kc85pev4.txt plain text: cord-326642-kc85pev4.txt item: #451 of 549 id: cord-326725-0jgw083h author: Klamroth, Robert title: Pathogen inactivation and removal methods for plasma‐derived clotting factor concentrates date: 2013-09-30 words: 5982 flesch: 32 summary: Studies on inactivation of HIV, HAV, and B19V by pasteurization in a FVIII/ VWF concentrate have demonstrated virus reduction factors of at least 6.4, 4.2, and at least 3.9 log, respectively. 71 Virus filtration alone resulted in virus reduction factors of at least 3.6 log, while combination of S/D, chromatography, and virus filtration yielded reduction factors of at least 5.1 log for all tested viruses. keywords: concentrates; factor; inactivation; manufacturing; plasma; products; reduction; removal; safety; transmission; treatment; virus; viruses cache: cord-326725-0jgw083h.txt plain text: cord-326725-0jgw083h.txt item: #452 of 549 id: cord-326744-eled2tgo author: Millett, Gregorio A. title: White Counties Stand Apart: The Primacy of Residential Segregation in COVID-19 and HIV Diagnoses date: 2020-10-01 words: 3232 flesch: 47 summary: Attributing racial disparities to underlying conditions implicitly blames communities of color for COVID-19 disparities due to poor health decisions; but there is ample literature showing how social determinants contribute to worse health outcomes in communities of color, 29 including well-cited HIV research studies of youth, gay men, and PWID, which show that HIV disparities persist in black communities despite similar or fewer behavioral risks than whites. Many point to underlying health conditions (e.g., obesity, hypertension, diabetes, heart disease) as the source of COVID-19 racial disparities. keywords: black; counties; covid-19; disparities; health; hiv; states; white cache: cord-326744-eled2tgo.txt plain text: cord-326744-eled2tgo.txt item: #453 of 549 id: cord-326833-boxgt4kb author: Marimuthu, Janakiram title: HIV and SARS CoV‐2 co‐infection: A retrospective, record based, case series from South India date: 2020-07-07 words: 1365 flesch: 59 summary: Coronavirus disease (COVID-19) Situation Report-161 4 Cases: HIV and SARS-CoV-2 Co-inf ection in patients from Long Island COVID-19 in patients with HIV: clinical case series COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients Clinical features and outcome of HIV/SARS-CoV-2 coinfected patients in The B ronx, New York city SARS-CoV-2 co-infected patients in Istanbul, Turkey HIV Facts & Figures | National AIDS Control Organization | MoHFW | GoI Could HIV infection alter the clinical course of SARS-CoV-2 infection? Bacterial and fungal infections in COVID-19 patients: A matter of concern. keywords: covid-19; hiv; infection; patients cache: cord-326833-boxgt4kb.txt plain text: cord-326833-boxgt4kb.txt item: #454 of 549 id: cord-327135-4c2flue4 author: Chinnaswamy, S title: Gene–disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections date: 2016-06-09 words: 9838 flesch: 39 summary: A recent report compared the strength of association of rs4803217 and rs368234815 in IFN treatment response in HCV-infected African Americans, who have the lowest reported LD values among all ethnicities between rs368234815 and rs12979860 SNPs (Figure 1b) . In case of IFN treatment response in chronic HCV infections, even though the IFN-λ4 -generating SNP can explain a large amount of variance in the observed phenotypes, 107 questions still remain on its role in spontaneous clearance of HCV. keywords: association; cells; expression; functional; hcv; hepatitis; ifn; ifnl; infections; interferon; patients; rs12979860; snps; studies; virus cache: cord-327135-4c2flue4.txt plain text: cord-327135-4c2flue4.txt item: #455 of 549 id: cord-327324-4c4a4bfz author: Wilkinson, Robert J title: Tuberculosis and type 2 Diabetes Mellitus: an inflammatory danger signal in the time of COVID-19 date: 2020-06-13 words: 874 flesch: 30 summary: This theory is Diabetes mellitus increases the risk of active tuberculosis: a systematic review of 13 observational studies Effect of glycemic control and type of diabetes treatment on unsuccessful TB treatment outcomes among people with TB-Diabetes: A systematic review The impact of diabetes on tuberculosis treatment outcomes: a systematic review Diabetes is a strong predictor of mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients from Mwanza, Tanzania Hyperglycemia during tuberculosis treatment increases morbidity and mortality in a contemporary cohort of HIV-infected patients in Rio de Janeiro, Brazil Stress hyperglycaemia Tuberculosis, HIV and the association with transient hyperglycaemia in peri-urban South Africa Consultation meeting on tuberculosis and diabetes mellitus: meeting summary and recommendations Infections in patients with diabetes mellitus: A review of pathogenesis Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections uninfected African adults using whole blood RNA expression signatures: a casecontrol study HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell subsets across tissues RJW is supported by the Francis Crick Institute which receives funding from Wellcome (FC0010218), UKRI (FC0010218) and CRUK (FC0010218). It is known that tuberculosis itself associates with transiently impaired glucose tolerance which may even be in the frank diabetic range, yet which may resolve during tuberculosis treatment keywords: diabetes; patients; tuberculosis cache: cord-327324-4c4a4bfz.txt plain text: cord-327324-4c4a4bfz.txt item: #456 of 549 id: cord-327461-ohgkgvry author: Lu, Ying title: Monetary incentives and peer referral in promoting digital network-based secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a three-arm randomized controlled trial date: 2020-06-12 words: 4424 flesch: 44 summary: Innovative interventions are needed to further expand the uptake of HIV testing among key populations. Innovative interventions are needed to further expand the uptake of HIV testing among key populations. keywords: arm; distribution; hiv; hivst; incentives; kits; msm; testing cache: cord-327461-ohgkgvry.txt plain text: cord-327461-ohgkgvry.txt item: #457 of 549 id: cord-328287-3qgzulgj author: Moni, Mohammad Ali title: Network-based analysis of comorbidities risk during an infection: SARS and HIV case studies date: 2014-10-24 words: 10661 flesch: 39 summary: The list of disorders, disease genes, and associations between them were obtained from the Online Mendelian Inheritance in Man (OMIM) [58] , a compendium of human disease genes and phenotypes (see details in the Methods section). keywords: cancer; comorbidities; comorbidity; cov; data; disease; expression; file; genes; hiv; human; infection; network; pathways; protein; risk; sars; table cache: cord-328287-3qgzulgj.txt plain text: cord-328287-3qgzulgj.txt item: #458 of 549 id: cord-329223-f84gjxm1 author: Kouokam, Joseph Calvin title: Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate date: 2011-08-02 words: 8854 flesch: 42 summary: In this work we expanded the safety studies to include analyses of off-target effects derived from GRFT binding cell surface oligomannose glycans on human PBMC as well as characterized ectocervical, endocervical and vaginal keratinocyte cell lines End1/E6E7, Ect1/E6E7 and VK2E6E7, which were originally established from normal human endocervical, ectocervical, and vaginal epithelia, respectively, and immortalized by expression of human papillomavirus 16/E6E7 In summary, our data provide further evidence that GRFT, an exceptionally potent antiviral lectin, has very minor effects on the molecular physiology of human cells. keywords: activity; antiviral; binding; cell; cona; data; e6e7; expression; fig; grft; human; lectins; lines; pbmc; pbs; surface; treatment cache: cord-329223-f84gjxm1.txt plain text: cord-329223-f84gjxm1.txt item: #459 of 549 id: cord-329361-0mpbau1b author: Bennasser, Yamina title: RNAi Therapy for HIV Infection: Principles and Practicalities date: 2012-08-16 words: 2651 flesch: 45 summary: HIV-1 tar RNA subverts RNA interferencein tion transfected cells through sequestration of tar RNA binding protein interference: viral diversion of a cellular pathway or evasion from antiviral 75 Conserved seed pairing, often flanked by HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. The introduction of small uses its guide RNA for base-pairing-mediated recognition of target RNA duplexes of 19 to 21 nucleotides into cells can elicit specific messenger RNA (mRNA). keywords: cells; hiv; infection; protein; rnai; sirna; target; virus cache: cord-329361-0mpbau1b.txt plain text: cord-329361-0mpbau1b.txt item: #460 of 549 id: cord-329396-cl28bjnd author: Carrico, Adam W. title: Double Jeopardy: Methamphetamine Use and HIV as Risk Factors for COVID-19 date: 2020-04-07 words: 2323 flesch: 28 summary: And it's everywhere HIV infection risk, prevention, and testing behaviors among men who have sex with men-National HIV Behavioral Surveillance Clear links between starting methamphetamine and increasing sexual risk behavior: a cohort study among men who have sex with men Walking the line: stimulant use during sex and HIV risk behavior among Black urban MSM Spirituality/religiosity, substance use, and HIV testing among young black men who have sex with men Critical review: when the party is over: a systematic review of behavioral interventions for substance-using men who have sex with men Amphetamine-type stimulants and HIV infection among men who have sex with men: implications on HIV research and prevention from a systematic review and meta-analysis Stimulant use and viral suppression in the era of universal antiretroviral therapy Psychiatric risk factors for HIV disease progression: the role of inconsistent patterns of antiretroviral therapy utilization Increased human immunodeficiency virus loads in active methamphetamine users are explained by reduced effectiveness of antiretroviral therapy Engagement in HIV medical care and technology use among stimulant-using and nonstimulant-using men who have sex with men Crack cocaine, disease progression, and mortality in a multicenter cohort of HIV-1 positive women Stimulant use and progression to AIDS or mortality after the initiation of highly active antiretroviral therapy Residual immune dysregulation syndrome in treated HIV infection Drugs of abuse, immune modulation, and AIDS Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse Brief report: recent methamphetamine use is associated with increased rectal mucosal inflammatory cytokines, regardless of HIV-1 serostatus Recent stimulant use and leukocyte gene expression in methamphetamine users with treated HIV infection Substance-associated elevations in monocyte activation among methamphetamine users with treated HIV infection Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection Inflammation, immune activation, and cardiovascular disease in HIV Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS Coronavirus Effect of methamphetamine dependence on heart rate variability Colon dysregulation in methamphetamine self-administering HIV-1 transgenic rats Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease Coronavirus may infect up to 70% of world's population, expert warns Day level forecasting for Coronavirus Disease (COVID-19) spread: analysis, modeling and recommendations 8 Men arrested for hosting drug-fuelled orgy during coronavirus lockdown in Spain 3 more gay men who went to the Winter Party test positive for coronavirus & others are getting sick With meetings banned, millions struggle to stay sober on their own Randomized controlled trial of a positive affect intervention for people newly diagnosed with HIV Randomized controlled trial of a positive affect intervention for methamphetamine users Randomized controlled trial of a positive affect intervention to reduce HIV viral load among sexual minority men who use methamphetamine The MARIGOLD study: feasibility and enhancement of an online intervention to improve emotion regulation in people with elevated depressive symptoms Feasibility and acceptability of an online positive affect intervention for those living with comorbid HIV depression A randomized pilot trial of a positive affect skill intervention (lessons in linking affect and coping) for women with metastatic breast cancer An online positive affect skills intervention reduces depression in adults with type 2 diabetes Theorybased text-messaging to reduce methamphetamine use and HIV sexual risk behaviors among men who have sex with men: automated unidirectional delivery outperforms bidirectional peer interactive delivery A pilot study of a mobile app to support HIV antiretroviral therapy adherence among men who have sex with men who use stimulants There is increasing evidence from our team and others that meth use can induce gut-immune dysregulation, even among those with treated HIV infection keywords: covid-19; hiv; men; meth; msm; use cache: cord-329396-cl28bjnd.txt plain text: cord-329396-cl28bjnd.txt item: #461 of 549 id: cord-329482-haenltxn author: Small, Eusebius title: Covid-19 and Gender in LMICs: Potential Lessons from HIV Pandemic date: 2020-05-25 words: 1583 flesch: 46 summary: Evidence from public census data COVID-19 could lead to millions of unintended pregnancies, new UN-backed data reveals Gender-Based Violence Increases Risk of HIV/AIDS for Women in Sub-Saharan Africa -Population Reference Bureau Experiences of gender-based violence among female sex workers, men who have sex with men, and transgender women in Latin America and the Caribbean: a qualitative study to inform HIV programming UK. For example, many HIV infected women will lack the essential antiretroviral therapy (ART) drugs, or pre-exposure prophylaxis (PreP) because of disruptions in the supply chain. keywords: covid-19; health; hiv; impact; violence; women cache: cord-329482-haenltxn.txt plain text: cord-329482-haenltxn.txt item: #462 of 549 id: cord-329890-wg23sa1u author: Quah, Stella R. title: Public image and governance of epidemics: Comparing HIV/AIDS and SARS date: 2007-02-28 words: 9741 flesch: 45 summary: In: Plenary address by Director of HIV/AIDS, WHO at the seventh international congress on AIDS in Asia and the Pacific World Health Organization [WHO] position statement on condoms and HIV prevention The politics of emerging and resurgent infectious diseases. I test two related assumptions: (1) a higher perception of disease severity and personal susceptibility to SARS as compared to HIV/AIDS, contributed to the higher effectiveness of SARS prevention efforts; (2) the second assumption is two-fold: (a) in contrast to SARS, the overall negative social 'image' of HIV/AIDS as a disease associated with particular types of individuals tends to weaken people's perception of susceptibility; (b) correspondingly, low perceived susceptibility tends to discourage public support for robust preventive efforts at the community level. keywords: aids; analysis; community; disease; health; hiv; image; people; prevention; public; respondents; sars; severity; susceptibility cache: cord-329890-wg23sa1u.txt plain text: cord-329890-wg23sa1u.txt item: #463 of 549 id: cord-330465-16j5vm7h author: Marciniec, Krzysztof title: Phosphate Derivatives of 3-Carboxyacylbetulin: SynThesis, In Vitro Anti-HIV and Molecular Docking Study date: 2020-08-05 words: 6962 flesch: 44 summary: Pentacyclic triterpenes and their semi-synthetic derivatives are a large group of compounds known to demonstrate biological activity, including antitumor, antiviral, antimalarial, Melting points of obtained compounds were measured in open capillary tubes on an Electrothermal melting point apparatus without correction. The experiments were carried out in media containing tested compounds in concentrations of the appropriate range. keywords: acid; activity; betulin; bvm; compounds; cov-2; derivatives; docking; figure; hiv; phosphate; protein; results; sars; table cache: cord-330465-16j5vm7h.txt plain text: cord-330465-16j5vm7h.txt item: #464 of 549 id: cord-330581-g5r2b043 author: Marini, Elena title: HIV‐1 matrix protein p17 binds to monocytes and selectively stimulates MCP‐1 secretion: role of transcriptional factor AP‐1 date: 2007-10-26 words: 8287 flesch: 46 summary: Cell Microbiol DOI: 10.1111/j.1462-5822.2007.01073.x sha: doc_id: 330581 cord_uid: g5r2b043 HIV‐1 matrix protein p17 activates a variety of cell responses which play a critical role in viral replication and infection. To assess whether the increase in MCP-1 protein levels induced by p17 treatment was paralleled by an increase in A. Purified monocytes were stained for p17R and HLA-DR expression, as described in Experimental procedures. keywords: activation; activity; ap-1; binding; cells; expression; human; monocytes; p17; p17r; protein; treatment cache: cord-330581-g5r2b043.txt plain text: cord-330581-g5r2b043.txt item: #465 of 549 id: cord-330698-9t24jo8s author: Wurdinger, Thomas title: Extracellular Vesicles and Their Convergence with Viral Pathways date: 2012-07-25 words: 7459 flesch: 33 summary: Shedding microvesicles: artefacts no more Exosomes: extracellular organelles important in intercellular communication Exosomes-vesicular carriers for intercellular communication Brain tumor microvesicles: insights into intercellular communication in the nervous system The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages Molecular characterization of dendritic cell-derived exosomes: selective accumulation of the heat shock protein hsc73 Membrane vesicles as conveyors of immune responses Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein Ceramide triggers budding of exosome vesicles into multivesicular endosomes Rab27a and Rab27b control different steps of the exosome secretion pathway The regulation of exosome secretion: a novel function of the p53 protein Rab11 promotes docking and fusion of multivesicular bodies in a calcium-dependent manner Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences Mechanisms for the formation of membranous nanostructures in cell-to-cell communication ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro Platelet-derived microvesicles transfer tissue factor to monocytes but not to neutrophils Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer Modulation of monocyte-endothelial cell interactions by platelet microparticles Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Functional delivery of viral miRNAs via exosomes Unraveling the mystery of cancer by secretory microRNA: horizontal microRNA transfer between living cells Immune-related microRNAs are abundant in breast milk exosomes Noncytotoxic suppression of human immunodeficiency virus type 1 transcription by exosomes secreted from CD8 + T cells Transfer of the chemokine receptor CCR5 between cells by membranederived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection Plateletand megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathway HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells Genetic characterization of HIV type 1 nef-induced vesicle secretion HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4 + T cells Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation Cytomegalovirusinfected human endothelial cells can stimulate allogeneic CD4 + memory T cells by releasing antigenic exosomes Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells Localization of the Epstein-Barr virus protein LMP 1 to exosomes Galectin-1 mediated suppression of Epstein-Barr virus-specific T-cell immunity in classic Hodgkin lymphoma Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells Interestingly, EBV facilitates these essential interactions for the maturation of B cells, for instance, by upregulation of crucial GC reaction-associated proteins, such as GP183 keywords: cells; ebv; elements; exosomes; hiv; human; immune; infected; infection; membrane; microvesicles; plasma; proteins; release; virus; viruses cache: cord-330698-9t24jo8s.txt plain text: cord-330698-9t24jo8s.txt item: #466 of 549 id: cord-330800-s91zfzfi author: Reta, Daniel Hussien title: Molecular and Immunological Diagnostic Techniques of Medical Viruses date: 2020-09-04 words: 10553 flesch: 40 summary: A H1N1 Virus 2009 by reverse-transcription loop-mediated isothermal amplification with hydroxynaphthol blue dye An updated loop-mediated isothermal amplification method for rapid diagnosis of H5N1 avian influenza viruses Loop-mediated isothermal amplification assay for rapid detection of hepatitis C virus Detection of acute HIV-1 infection by RT-LAMP Detection of Zika virus using reverse-transcription LAMP coupled with reverse dot blot analysis in saliva Infectious diseases detection by microarray: an overview of clinical relevant infections Utility of DNA microarrays for detection of viruses in acute respiratory tract infections in children Detection of herpesvirus and adenovirus co-infections with diagnostic DNA-microarrays DNA microarrays for virus detection in cases of central nervous system infection DNA microarray for detection of gastrointestinal viruses DNA microarray platform for detection and surveillance of viruses transmitted by small mammals and arthropods DNA probe array for the simultaneous identification of herpesviruses, enteroviruses, and flaviviruses Characterization of real-time microarrays for simultaneous detection of HIV-1, HIV-2, and hepatitis viruses A DNA microarray-based assay to detect dual infection with two dengue virus serotypes An efficient microarray-based genotyping platform for the identification of drug-resistance mutations in majority and minority subpopulations of HIV-1 Quasispecies Development of a simple microarray for genotyping HIV-1 drug resistance mutations in the reverse transcriptase gene in rural Tanzania Microarray-based genotyping and detection of drug-resistant HBV mutations from 620 Chinese patients with chronic HBV infection Development of a single nucleotide polymorphism DNA microarray for the detection and genotyping of the SARS coronavirus Diagnostic microarray for influenza B viruses Viral discovery and sequence recovery using DNA microarrays Metagenomics and the molecular identification of novel viruses DNA microarrays: types, applications and their future Next-generation sequencing for infectious disease diagnosis and management Current approaches for diagnosis of influenza virus infections in humans Application of next generation sequencing in clinical microbiology and infection prevention Assessing the performance of the Oxford nanopore technologies MinION Nanopore sequencing and assembly of a human genome with ultra-long reads Rapid and accurate sequencing of enterovirus genomes using MinION nanopore sequencer Whole genome sequencing of influenza A and B viruses with the MinION sequencer in the clinical setting: a pilot study Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples A method to identify respiratory virus infections in clinical samples using nextgeneration sequencing Evolutionary dynamics of local pandemic H1N1/2009 influenza virus lineages revealed by whole-genome analysis First evaluation of the Next-Generation Sequencing platform for the detection of HIV-1 drug resistance mutations in Belgium Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda Next-generation sequencing and bioinformatic approaches to detect and analyze influenza virus in ferrets Metagenomic nextgeneration sequencing aids the diagnosis of viral infections in febrile returning travellers Nucleoprotein-based indirect enzyme-linked immunosorbent assay (indirect ELISA) for detecting antibodies specific to Ebola virus and Marbug virus Evaluation of antibody testing for SARS-CoV-2 using ELISA and lateral flow immunoassays Evaluation of ELISA tests for the qualitative determination of IgG, IgM and IgA to SARS-CoV-2 Development of an enzyme-linked immunosorbent assay for rapid detection of dengue virus (DENV) NS1 and differentiation of DENV serotypes during early infection Transmission of Herpes simplex virus type 2 among factory workers in Ethiopia Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in SARS patients by enzyme-linked immunosorbent assay Detection of hepatitis A, B, and C virus-specific antibodies using oral fluid for epidemiological studies Newly established monoclonal antibodies for immunological detection of H5N1 influenza virus High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses Laboratory diagnostics for HIV infection Development of a Western blot assay for detection of antibodies against coronavirus causing severe acute respiratory syndrome Western blot detection of human anti-Chikungunya virus antibody with recombinant envelope 2 protein Western blot-based logistic regression model for the identification of recent HIV-1 infection: a promising HIV-1 surveillance approach for resource-limited regions Early detection of anti-HCc antibody in acute hepatitis C virus (HCV) by western blot (immunoblot) using a recombinant HCV core protein fragment Detection of human immunodeficiency virus type 1 (HIV-1) antibody by western blotting and HIV-1 DNA by PCR in patients with AIDS Western blot profile in HIV infection Accuracy of rapid influenza diagnostic test and immunofluorescence assay compared to real time RT-PCR in children with influenza A(H1N1)pdm09 infection Immunofluorescence assay for serologic diagnosis of SARS Detection of herpes simplex virus in direct specimens by immunofluorescence assay using a monoclonal antibody Comparative evaluation of a simple indirect immunofluorescence test and mouse neutralization test for assaying rabies antibodies Molecular diagnostic techniques provide rapid viral detection in patient sample. keywords: amplification; assay; detection; diagnosis; dna; elisa; human; infection; influenza; pcr; reaction; rna; samples; sars; sensitivity; specificity; time; virus; viruses cache: cord-330800-s91zfzfi.txt plain text: cord-330800-s91zfzfi.txt item: #467 of 549 id: cord-330852-n7j0c4ne author: Fischer, Wolfgang B. title: Mechanism of Function of Viral Channel Proteins and Implications for Drug Development date: 2012-02-23 words: 23723 flesch: 45 summary: An increasing number of proteins are identified as channel proteins, but the precise role in the viral life cycle is yet unknown for the majority of them. The question emerges why the virus needs three channels while all other channel expressing viruses known to date proteins only need one type of channel protein. keywords: activity; amantadine; amino; assembly; channel; channel activity; channel protein; data; domain; drug; et al; function; helix; host; influenza; ion; ion channel; lipid; mechanism; membrane; membrane protein; nmr; peptide; pore; protein; proton; residues; state; structure; studies; tmd; tmds; virus; virus protein; vpu; vpu protein cache: cord-330852-n7j0c4ne.txt plain text: cord-330852-n7j0c4ne.txt item: #468 of 549 id: cord-330970-6kkqoh7f author: Weiss, Robin A title: Apes, lice and prehistory date: 2009-02-10 words: 5109 flesch: 73 summary: So was there duplication and separation of lice in the African anthropoid ape lineage, where they could have occupied separate ecological niches, rather as human head lice and pubic lice do today? Such infidelity may account for the survival of certain types of human lice, and it is currently exemplified by viruses such as HIV. keywords: body; hair; head; host; human; lice; species cache: cord-330970-6kkqoh7f.txt plain text: cord-330970-6kkqoh7f.txt item: #469 of 549 id: cord-331289-02411gfv author: Di Minno, Giovanni title: Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders() date: 2015-07-20 words: 8176 flesch: 34 summary: receiver operating characteristic analysis Placental transmission of human parvovirus 4 in newborns with hydrops Serodiagnosis of primary infections with human parvovirus 4, Finland Human parvovirus 4 infection Human parvovirus 4 viremia in young children Novel parvovirus and related variant in human plasma Detection of a novel DNA virus (TTV) in blood donors and blood products Validation of SYBR Green based quantification assay for the detection of human Torque Teno virus titers from plasma West Nile Virus: Detection with Serologic and Real-time PCR Assays Diagnosis of west nile virus human infections: overview and proposal of diagnostic protocols considering the results of external quality assessment studies Second international diagnostic accuracy study for the serological detection of West Nile virus infection Global incidence and prevalence of selected curable sexually transmitted infections Use of PCR in the diagnosis of early syphilis in the United Kingdom Evaluation of a PCR test for detection of treponema pallidum in swabs and blood The laboratory diagnosis of syphilis Current advances in detection and treatment of babesiosis A new real-time PCR assay for improved detection of the parasite Babesia microti Multiplex assay detection of immunoglobulin G antibodies that recognize Babesia microti antigens World Health Organisation (WHO) Guidelines on viral inactivation and removal procedures intended to assure the viral safety of human blood plasma products keywords: assays; blood; detection; donors; hbv; hepatitis; human; infection; nat; pathogen; plasma; products; risk; safety; screening; transfusion; transmission; use; virus cache: cord-331289-02411gfv.txt plain text: cord-331289-02411gfv.txt item: #470 of 549 id: cord-331673-xv1tcugl author: Reina, Giacomo title: Hard Nanomaterials in Time of Viral Pandemics date: 2020-07-15 words: 15723 flesch: 39 summary: Different functionalized CDs were prepared to hamper host cell viral entry. Overall, graphene materials have shown a good capacity to block host cell viral entry. keywords: activity; agents; agnps; cells; drug; effect; entry; fullerene; hiv; hnms; host; host cells; immune; infection; influenza; inhibition; interaction; mechanism; nanoparticles; replication; response; silver; surface; virus; viruses; vitro cache: cord-331673-xv1tcugl.txt plain text: cord-331673-xv1tcugl.txt item: #471 of 549 id: cord-331879-w7008uyy author: Iversen, Jenny title: COVID‐19, HIV and key populations: cross‐cutting issues and the need for population‐specific responses date: 2020-10-01 words: 3691 flesch: 31 summary: The negative consequences of these measures on general population health and well-being, such as mental health issues arising from isolation, loss of income and residential instability, will be exacerbated in vulnerable key populations who lack the resources to physically distance or who do not have access to social safety nets or the option of working from home [6] . key: cord-331879-w7008uyy authors: Iversen, Jenny; Sabin, Keith; Chang, Judy; Morgan Thomas, Ruth; Prestage, Garrett; Strathdee, Steffanie A; Maher, Lisa title: COVID‐19, HIV and key populations: cross‐cutting issues and the need for population‐specific responses date: 2020-10-01 journal: J Int AIDS Soc DOI: 10.1002/jia2.25632 sha: doc_id: 331879 cord_uid: w7008uyy INTRODUCTION: keywords: covid-19; health; hiv; pandemic; people; populations; sex; workers cache: cord-331879-w7008uyy.txt plain text: cord-331879-w7008uyy.txt item: #472 of 549 id: cord-332093-iluqwwxs author: Lessler, Justin title: Mechanistic Models of Infectious Disease and Their Impact on Public Health date: 2016-02-17 words: 5503 flesch: 26 summary: Even outside of public health crises, infectious disease models play an important role in setting public health policy. Infectious disease models play a critical role in incorporating indirect effects that can vary substantially across alternative programs. keywords: control; disease; dynamics; epidemic; health; impact; influenza; models; number; pandemic; transmission; vaccination cache: cord-332093-iluqwwxs.txt plain text: cord-332093-iluqwwxs.txt item: #473 of 549 id: cord-332396-nattdect author: Ejima, K. title: HIV testing by public health centers and municipalities, and new HIV cases during the COVID-19 pandemic in Japan date: 2020-10-18 words: 3636 flesch: 53 summary: The number of HIV tests (9,584 vs. 35,908 in the year-before period) and consultations (11,689 vs. 32,565) performed by public health centers significantly declined in the second quarter of 2020, while the proportion of HIV cases with AIDS diagnosis among all HIV cases (36.2% vs. 26.4%) significantly increased after removing the trend and seasonality effects. Evidence before this study 25 Before this study, we searched PubMed, Medline, and Google Scholar on Oct 12, 2020, for articles 26 investigated the number of HIV test and HIV cases during the COVID-19 pandemic in Japan, using the 27 search terms novel coronavirus or SARS-CoV-2, and HIV or AIDS, and Japan, with no time 28 restrictions. keywords: aids; cases; diagnosis; hiv; preprint cache: cord-332396-nattdect.txt plain text: cord-332396-nattdect.txt item: #474 of 549 id: cord-332569-af8oq2d6 author: Friedman, Henry title: The Critical Role of Nonhuman Primates in Medical Research date: 2017-08-23 words: 4633 flesch: 53 summary: â�¢ Naturally regenerative mechanism discovered in the mature NHP brain, spurring new research toward curing Alzheimer's and other degenerative brain disorders. Monkeys are crucial to ongoing HIV research because of the combination of their unique biology among animals and their longevity, which is key in HIV studies that take from months to years to complete. keywords: brain; development; disease; hiv; human; monkeys; research; use; � ¢ cache: cord-332569-af8oq2d6.txt plain text: cord-332569-af8oq2d6.txt item: #475 of 549 id: cord-332588-k4tghibp author: D’Alessandro, Sarah title: The Use of Antimalarial Drugs against Viral Infection date: 2020-01-08 words: 9397 flesch: 38 summary: Viruses Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo guinea pig model A systematic screen of FDA-approved drugs for inhibitors of biological threat agents Chloroquine could be used for the treatment of filoviral infections and other viral infections that emerge or emerged from viruses requiring an acidic pH for infectivity Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine Hepatitis C virus entry depends on clathrin-mediated endocytosis Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases Inhibition of human immunodeficiency virus infectivity by chloroquine Inhibition of human immunodeficiency virus type 1 replication by hydroxychloroquine in T cells and monocytes Inhibition of HIV-1 replication by hydroxychloroquine: Mechanism of action and comparison with zidovudine The anti-HIV-1 activity of chloroquine The potential place of chloroquine in the treatment of HIV-1-infected patients Anti-HIV effects of chloroquine: Inhibition of viral particle glycosylation and synergism with protease inhibitors Effect of chloroquine on reducing HIV-1 replication in vitro and the DC-SIGN mediated transfer of virus to CD4+ T-lymphocytes Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands In vitro inhibition of human influenza A virus replication by chloroquine Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection An evaluation of Chloroquine as a broad-acting antiviral against Hand, Foot and Mouth Disease Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity Establishment of an antiviral assay system and identification of severe fever with thrombocytopenia syndrome virus inhibitors Primaquine diphosphate: Inhibition of Newcastle disease virus replication Antimalarial pharmacology and therapeutics of atovaquone Atovaquone Inhibits Arbovirus Replication through the Depletion of Intracellular Nucleotides Inhibitory effect of doxycycline against dengue virus replication in vitro A combination of doxycycline and ribavirin alleviated chikungunya infection Antiviral activity of doxycycline against vesicular stomatitis virus in vitro Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: Involvement of matrix metalloproteinases A highly sensitive and selective assay of doxycycline by dualwavelength overlapping resonance Rayleigh scattering Brucella infection with pancytopenia after pediatric liver transplantation Bioactive implant surface with electrochemically bound doxycycline promotes bone formation markers in vitro and in vivo Susceptibility of Plasmodium falciparum isolates to doxycycline is associated with pftetQ sequence polymorphisms and pftetQ and pfmdt copy numbers Doxycycline inhibits proliferation and induces apoptosis of both human papillomavirus positive and negative cervical cancer cell lines. Clinical studies for the assessment of antimalarial drug activity against viral infection. keywords: activity; antiviral; art; artesunate; cells; chloroquine; drugs; effect; human; infection; mefloquine; patients; progressive; replication; treatment; virus; vitro cache: cord-332588-k4tghibp.txt plain text: cord-332588-k4tghibp.txt item: #476 of 549 id: cord-332610-t99l3zii author: Mayer, J.D. title: Emerging Diseases: Overview date: 2008-08-26 words: 9597 flesch: 50 summary: However, it is impossible to say when the terms 'emerging infection' or 'emerging infectious diseases' were first used to describe new infectious diseases, or diseases that meet the criteria that are described in this article. In discussions of emergence, both 'emerging infections' and 'emerging infectious diseases' are commonly found. keywords: aids; cases; diseases; fever; health; hiv; infections; influenza; new; outbreak; people; public; sars; spread; states; syndrome; united cache: cord-332610-t99l3zii.txt plain text: cord-332610-t99l3zii.txt item: #477 of 549 id: cord-333405-ji58jbct author: Morens, David M. title: The challenge of emerging and re-emerging infectious diseases date: 2004-07-08 words: 6423 flesch: 33 summary: Germs and Genocide in Hawai'i Agents of Apocalypse: Epidemic Disease in the Colonial Philippines Measles in Fiji, 1875: thoughts on the history of emerging infectious diseases Die Aetiologie der Milzbrand-Krankheit, begründet auf die Entwicklungsgeschichte des Bacillus Anthracis. Microbial Threats to Health in the United States: Emergence, Detection and Response Emerging and re-emerging infectious diseases: a multidisciplinary perspective Emerging and re-emerging infectious diseases Infectious history Emerging infectious diseases in the 21st century Emerging and re-emerging infectious diseases Human Frontiers, Environments and Disease The origins of acquired immune deficiency viruses: where and when? keywords: agents; aids; dengue; diseases; eis; emergence; factors; health; hiv; human; infections; influenza; microbial; new; vaccines; virus; viruses cache: cord-333405-ji58jbct.txt plain text: cord-333405-ji58jbct.txt item: #478 of 549 id: cord-333622-0ddutmdd author: Dyer, Wayne B title: Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection date: 2008-12-11 words: 5635 flesch: 38 summary: Gag CTL responses was associated with low (<100 copies/ml) or undetectable viraemia (p = 0.032). Another study of HLA B57 positive individuals found no association between disease progression and the strength of CTL responses or the emergence of viral escape mutants at these epitopes, but it was found that viral replicative fitness influenced disease course [36] . keywords: cell; ctl; gag; hiv; infection; non; p24; progression; responses; viraemia cache: cord-333622-0ddutmdd.txt plain text: cord-333622-0ddutmdd.txt item: #479 of 549 id: cord-333655-lylt7qld author: Van Breedam, Wander title: Bitter‐sweet symphony: glycan–lectin interactions in virus biology date: 2013-12-06 words: 18704 flesch: 25 summary: Reading et al., 1997; Kase et al., 1999; Hartshorn et al., 2000; Hillaire et al., 2011) . Although SP-A may interact with some IAV isolates in a similar manner (Malhotra et al., 1994) , binding of this molecule to most of the IAV variants tested to date appears not to involve the lectin activity of SP-A; in contrast, virus binding depends on the interaction of the viral hemagglutinin with a sialylated N-glycan on the SP-A CRD (Hartshorn et al., 1994; Benne et al., 1995 Benne et al., , 1997 Hartshorn et al., 1997; van Eijk et al., 2003; Mikerov et al., 2008) . keywords: acid; activity; binding; cell; dendritic; eijk et; et al; glycan; glycosylation; gp120; hartshorn et; hemagglutinin; hiv; host; host lectins; human; iav; immune; infection; influenza; interactions; lectins; membrane; protein; receptors; recognition; sign; surface; target; type; virions; virus; viruses cache: cord-333655-lylt7qld.txt plain text: cord-333655-lylt7qld.txt item: #480 of 549 id: cord-333730-qsx0m68e author: Tsai, Y. C. title: Oral disease-modifying antirheumatic drugs and immunosuppressants with antiviral potential, including SARS-CoV-2 infection: a review date: 2020-09-03 words: 4934 flesch: 26 summary: The Swiss HIV cohort study The HYDILE trial: efficacy and tolerance of a quadruple combination of reverse transcriptase inhibitors versus the same regimen plus hydroxyurea or hydroxyurea and interleukin-2 in HIV-infected patients failing protease inhibitorbased combinations Activity, safety, and immunological effects of hydroxyurea added to didanosine in antiretroviral-naive and experienced HIV type 1-infected subjects: a randomized, placebo-controlled trial, ACTG 307 A randomized trial to investigate the recycling of stavudine and didanosine with and without hydroxyurea in salvage therapy (RESTART) Hydroxyurea as an inhibitor of hepatitis C virus RNA replication Hydroxyurea suppresses HCV replication in humans: a phase I trial of oral hydroxyurea in chronic hepatitis C patients Amazing results with hydroxyurea therapy in chronic hepatitis B: a preliminary report Reactivation of hepatitis B virus during treatment with hydroxyurea in an elderly patient with essential thrombocythemia Reversible inhibition of herpes simplex virus replication by hydroxyurea Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes Hydroxyurea inhibits parvovirus B19 replication in erythroid progenitor cells Original research: parvovirus B19 infection in children with sickle cell disease in the hydroxyurea era A novel action of minocycline inhibition of human immunodeficiency virus type 1 infection in microglia Neuroprotective and anti-human immunodeficiency virus activity of minocycline Minocycline treatment for HIV-associated 20 journals.sagepub.com/home/tab cognitive impairment: results from a randomized trial Randomized trial of minocycline in the treatment of HIV-associated cognitive impairment Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis Minocycline differentially modulates viral infection and persistence in an experimental model of Japanese encephalitis Minocycline trial in Japanese encephalitis: a double blind, randomized placebo study Role of oral minocycline in acute encephalitis syndrome in India: a randomized controlled trial Drug repurposing of minocycline against dengue virus infection Antibiotic minocycline prevents respiratory syncytial virus infection Antiinflammatory and antiviral effects of minocycline in enterovirus 71 infections Transcriptomic characterization of the novel avian-origin influenza A (H7N9) virus: specific host response and responses intermediate between avian (H5N1 and H7N7) and human (H3N2) viruses and implications for treatment options Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells Minocycline delays disease onset and mortality in reovirus encephalitis Therapy with minocycline aggravates experimental rabies in mice Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection Broadspectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide Successful treatment of acyclovirresistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man Leflunomide in the treatment of a pseudotumoral genital herpes simplex virus infection in an HIV patient Inhibition of HIV replication by A77 1726, the active metabolite of leflunomide, in combination with pyrimidine nucleoside reverse transcriptase inhibitors Anti-HIV-1 activity of leflunomide: a comparison with mycophenolic acid and hydroxyurea Ther Adv Musculoskelet Dis DOI: 10.1177/1759720x20947296 sha: doc_id: 333730 cord_uid: qsx0m68e There have been several episodes of viral infection evolving into epidemics in recent decades, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the latest example. keywords: activity; covid-19; disease; hiv; hydroxyurea; infection; leflunomide; minocycline; patients; replication; sars; treatment; trial; virus cache: cord-333730-qsx0m68e.txt plain text: cord-333730-qsx0m68e.txt item: #481 of 549 id: cord-334010-gxu0refq author: Banerjee, Nilotpal title: Viral glycoproteins: biological role and application in diagnosis date: 2016-01-18 words: 6667 flesch: 42 summary: During maturation from host cell viruses have Viral glycoproteins: biological role and application in diagnosis 7 host glycoproteins on their surface to avoid the immunity of the host. NS1) University of Texas Medical Branch at Galveston Dengue vaccines: challenges, development, current status and prospects Cellular and humoral immunity to varicella zoster virus glycoproteins in immune and susceptible human subjects Human arbovirus infections worldwide Dengue viral infections Influenza, epidemiology and prevention of vaccine-preventable diseases Carbohydrates of human immunodeficiency virus Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: an update for Probing virus-glycan interactions using glycan microarrays Chikungunya: a bending reality Evaluation of a dengue NS1 antigen detection assay sensitivity and specificity for the diagnosis of acute dengue virus infection Glycan receptor for influenza virus Approaches for the development of rapid serological assays for surveillance and diagnosis of infections caused by zoonotic flaviviruses of the japanese encephalitis virus serocomplex Fatal cases of Chikungunya virus infection in Colombia: diagnostic and treatment challenges Development of global consensus of dengue virus envelope glycoprotein for epitopes based vaccine design Influenza Symptoms and the Role of Laboratory Diagnostics, Health Professionals, Seasonal. keywords: cell; dengue; diagnosis; ebola; envelope; glycan; glycoproteins; hiv; host; human; infection; influenza; role; virus; viruses cache: cord-334010-gxu0refq.txt plain text: cord-334010-gxu0refq.txt item: #482 of 549 id: cord-334104-mphz1aye author: Apisarnthanarak, Anucha title: Etiology of Community-Acquired Pneumonia date: 2005-03-28 words: 3493 flesch: 28 summary: The impact of potent antiretroviral therapy on the characteristics of hospitalized patients with HIV infections Communityacquired bacterial pneumonia in human immunodeficiency virus-infected patients Community-acquired pneumonia in a cohort of former injection drug users with and without human immunodeficiency virus infection: incidence, etiologies and clinical aspects Bacterial pneumonia in persons infected with the human immunodeficiency virus Pyogenic bacterial pneumonia in human immunodeficiency virus-infected inpatients: a clinical, radiological, microbiological, and epidemiological study Risk factors for community-acquired pneumonia among persons infected with human immunodeficiency virus A controlled trial of trimethoprim-sulfamethoxazole or aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with human immunodeficiency syndrome Pulmonary complications of HIV infection: autopsy findings The etiology of community-acquired pneumonia at an urban public hospital: influence of human immunodeficiency virus infection and initial severity of illness Pseudomonas spp complications in patients with HIV disease: an eight-year clinical and microbiology survey Incidence of tuberculosis in the United States among HIV-infected persons: the pulmonary complications of HIV Infection Study Group Tuberculosis and HIV infection: a cohort study of incidence and susceptibility to tuberculosis drugs Tuberculosis in patients with human immunodeficiency virus infection Site of disease and opportunistic infection predict survival in HIV-associated tuberculosis Isolated pulmonary Mycobacterium avium complex infection in patients with human immunodeficiency virus infection: case reports and literature review Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy Treatment of acute cryptococcal disease Dual pulmonary infection with Mycobacterium tuberculosis and Pneumocystis carinii in patients infected with human immunodeficiency virus Trimetrexate in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome A possible clue to help diagnose M pneumoniae pneumonia is a history of contact with a person with a similar condition characterized by a long incubation period. keywords: cap; disease; hiv; infection; patients; pneumonia; risk; tuberculosis cache: cord-334104-mphz1aye.txt plain text: cord-334104-mphz1aye.txt item: #483 of 549 id: cord-334133-61om170g author: Hollier, Mark J. title: The C-terminal tail of the gp41 transmembrane envelope glycoprotein of HIV-1 clades A, B, C, and D may exist in two conformations: an analysis of sequence, structure, and function date: 2005-07-05 words: 8480 flesch: 46 summary: They have distinct preferences for specific residues or combinations of residues of the tyrosine signals, although there is overlap, particularly with AP-1 and AP-3 complexes (Table 2) (Boll et al., 1996; Ohno et al., 1996 Ohno et al., , 1998 . complexes have the broadest specificity range and associate with the same signals as AP-1 and AP-3 complexes (Ohno et al., 1998) . keywords: cell; envelope; et al; gp160; gp41; human; immunodeficiency; membrane; msd; residues; signal; sorting; type; tyrosine; virus cache: cord-334133-61om170g.txt plain text: cord-334133-61om170g.txt item: #484 of 549 id: cord-334454-cqaado3u author: Leal, Rodolfo Oliveira title: The Use of Recombinant Feline Interferon Omega Therapy as an Immune-Modulator in Cats Naturally Infected with Feline Immunodeficiency Virus: New Perspectives date: 2016-10-27 words: 4323 flesch: 37 summary: APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells HIV replication can be blocked by recombinant human interferon beta Cohorts for the study of HIV-1-exposed but uninfected individuals: Benefits and limitations Interferon responses in HIV infection: From protection to disease Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration Use of recombinant interferon omega in feline retrovirosis: From theory to practice Therapeutic effects of recombinant feline interferon-omega on feline leukemia virus (FeLV)-infected and FeLV/feline immunodeficiency virus (FIV)-coinfected symptomatic cats Immunomodulation and therapeutic effects of the oral use of interferon-alpha: Mechanism of action Susceptibility of feline herpesvirus 1 and a feline calicivirus to feline interferon and recombinant human leukocyte interferons Low-dose interferon-alpha treatment for feline immunodeficiency virus infection Inhibitory effects of ribavirin alone or combined with human alpha interferon on feline infectious peritonitis virus replication in vitro Alpha interferon (2b) in combination with zidovudine for the treatment of presymptomatic feline leukemia virus-induced immunodeficiency syndrome Antiviral potency of interferon omega against selected canine and feline viruses Oral Recombinant Feline Interferon-Omega as an alternative immune modulation therapy in FIV positive cats: Clinical and laboratory evaluation Relevance of feline interferon omega for clinical improvement and reduction of concurrent viral excretion in retrovirus infected cats from a rescue shelter Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega Monitoring acute phase proteins in retrovirus infected cats undergoing feline interferon-ω therapy The acute-phase protein response to human immunodeficiency virus infection in human subjects Lipid and acute-phase protein alterations in HIV-1 infected patients in the early stages of infection: Correlation with CD4+ lymphocytes. The company only sponsored the above mentioned research work in a practical manner by donating rFeIFN-ω (Virbagen) which was administered to FIV cats. keywords: cats; feline; fiv; immune; protocol; rfeifn cache: cord-334454-cqaado3u.txt plain text: cord-334454-cqaado3u.txt item: #485 of 549 id: cord-334855-s0ci3r8w author: Andersen, Petter I. title: Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine date: 2019-10-18 words: 4295 flesch: 43 summary: For testing the production of HSV-2 and EV1 viruses in compound-treated and non-treated RPE cells, the media from the cells were serially (10-fold) diluted, starting from 10 −3 to 10 −8 in serum-free growth media containing 0.2% bovine serum albumin, and applied to a monolayer of A549-Npro cells in 12-well plates. This result indicates that obatoclax and emetine target distinct cellular pathways essential for virus infection. keywords: bsaas; cells; compounds; drug; emetine; ev1; fluav; gfp; hsv-2; novel; obatoclax; virus cache: cord-334855-s0ci3r8w.txt plain text: cord-334855-s0ci3r8w.txt item: #486 of 549 id: cord-337315-qv8ycdhe author: Miller, Maureen title: Integrated biological–behavioural surveillance in pandemic-threat warning systems date: 2017-01-01 words: 4631 flesch: 31 summary: For example, poverty can place individuals and communities at the forefront of zoonotic disease risk through several mechanisms. Current pandemic-threat warning systems rely almost exclusively on disease surveillance in clinical settings. keywords: data; disease; ebola; exposure; factors; human; outbreak; outcome; pandemic; risk; spillover; surveillance; transmission; virus; zoonotic cache: cord-337315-qv8ycdhe.txt plain text: cord-337315-qv8ycdhe.txt item: #487 of 549 id: cord-337458-dc90ecfe author: Markwalter, Christine F. title: Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics date: 2018-12-04 words: 40616 flesch: 31 summary: In addition to supplying functional groups for further bioconjugation, the silica encapsulation of other nanoparticles provides biocompatibility and protects the core material from degradation, making it a suitable strategy for the preparation of diagnostic nanoparticle detection probes. Given the prevalence of carboxylates and primary amines on nanoparticle surfaces and molecular recognition elements, one of the most common bioconjugation strategies for generating functionalized nanoparticle detection probes is the formation of amide bonds. keywords: acid; affinity; amplification; analysis; antibodies; antibody; antigen; applications; assay; biomarker; blood; care; colorimetric; complexes; concentration; detection; development; device; diagnostic; disease; dna; elements; field; figure; flow; flow assay; fluorescent; format; gold; hemozoin; hiv; hrp2; immunoassay; influenza; instrumentation; labels; light; malaria; metal; method; mobile; nanoparticles; nucleic; paper; point; preparation; probes; protein; quantum; recognition; resource; sample; section; sensitivity; settings; signal; silver; specific; strategies; surface; target; test; time; use cache: cord-337458-dc90ecfe.txt plain text: cord-337458-dc90ecfe.txt item: #488 of 549 id: cord-337659-x4oywbrj author: Wilson, Brenda A. title: Global biosecurity in a complex, dynamic world date: 2008-07-31 words: 10629 flesch: 38 summary: Pollution and exposure to waste water or sewage can also lead to the emergence of new diseases. The Global Alert and Response Network (GOARN) was established in 2000 by WHO as a partnership of >140 institutions and networks to mobilize human and technical resources for the rapid identification and control of disease outbreaks that are of international importance [88] . keywords: animals; biosecurity; cholera; deaths; disease; drug; epidemic; food; global; health; hiv; human; new; outbreak; public; resistance; response; spread; transmission; u.s; virus; world cache: cord-337659-x4oywbrj.txt plain text: cord-337659-x4oywbrj.txt item: #489 of 549 id: cord-337720-kmwft059 author: Closson, Kalysha title: When Home is Not a Safe Place: Impacts of Social Distancing Directives on Women Living with HIV date: 2020-06-02 words: 1743 flesch: 35 summary: As the health care system, and HIV care, may be the first line of violence support for many women living with HIV, during these unprecedented times, it is especially important that HIV care providers take a women-centred trauma-aware approach, which is led by the needs and priorities of their patients [21, 22] . As HIV care, research participation, and workplace settings are being transitioned to virtual and telephone-based methods, women living with HIV experiencing violence are less able to connect to critical social and protective networks [18] . keywords: covid-19; hiv; ipv; violence; women cache: cord-337720-kmwft059.txt plain text: cord-337720-kmwft059.txt item: #490 of 549 id: cord-337897-hkvll3xh author: Yang, Zheng Rong title: Peptide Bioinformatics- Peptide Classification Using Peptide Machines date: 2009 words: 7635 flesch: 49 summary: We then generate validation peptides using one fold and generate training peptides from the remaining folds. In building a computer model for a real application, there are two important issues for model validation in addition to model parameter estimation. keywords: classification; data; drug; function; method; model; peptides; prediction; protease; protein; resistance; sites; validation; vector cache: cord-337897-hkvll3xh.txt plain text: cord-337897-hkvll3xh.txt item: #491 of 549 id: cord-338438-q5fis2v8 author: Young, Sean D. title: Clinical Care, Research, and Telehealth Services in the Era of Social Distancing to Mitigate COVID-19 date: 2020-05-21 words: 1446 flesch: 34 summary: COVID-19 will continue to impact the way that technologies are integrated into HIV clinical care and research long after the removal of social distancing policies, making it important to begin investing in the knowledge, infrastructure, and implementation of these technologies now to be prepared for the future. Findings suggest that these tools are especially impactful when delivered based on specific rather than general needs (e.g., keeping HIV patients engaged in sociallydistanced care), and on evidenced-based behavioral and social science frameworks. keywords: care; covid-19; hiv; patients cache: cord-338438-q5fis2v8.txt plain text: cord-338438-q5fis2v8.txt item: #492 of 549 id: cord-338572-5ifc2lx6 author: Nagarakanti, Sandhya R. title: Clinical outcomes of patients with COVID‐19 and HIV coinfection date: 2020-09-19 words: 1599 flesch: 48 summary: These data points included HIV-associated characteristics such as most recent CD4+ T cells, CD4/CD8 ratio, ( obtained by flow cytometry Clinical outcomes of hospitalized patients were compared to that of a propensity matched cohort of COVID-19 patients who had no history of HIV infection. We present the clinical outcomes of HIV patients hospitalized for COVID‐19 in a matched comparison with historical controls. keywords: covid-19; hiv; infection; outcomes; patients cache: cord-338572-5ifc2lx6.txt plain text: cord-338572-5ifc2lx6.txt item: #493 of 549 id: cord-338594-wft7yy6j author: Winkler, Michael title: Rhesus macaque IFITM3 gene polymorphisms and SIV infection date: 2017-03-03 words: 4642 flesch: 37 summary: key: cord-338594-wft7yy6j authors: Winkler, Michael; Gärtner, Sabine; Wrensch, Florian; Krawczak, Michael; Sauermann, Ulrike; Pöhlmann, Stefan title: Rhesus macaque IFITM3 gene polymorphisms and SIV infection date: 2017-03-03 journal: PLoS One DOI: 10.1371/journal.pone.0172847 sha: doc_id: 338594 cord_uid: wft7yy6j Interferon-induced transmembrane proteins (IFITMs) have been recognized as important antiviral effectors of the innate immune system, both in cell culture and in infected humans. This is noteworthy since IFITM3 polymorphisms in SIV-infection the N-terminal residues of IFITM3 control intracellular localization and spectrum of antiviral activity [32, 43, 44] and were suggested to be shaped by selective pressure during primate evolution [32] . keywords: animals; association; cohort; gene; human; infection; polymorphisms; proteins; rhesus; rhifitm3; siv; virus cache: cord-338594-wft7yy6j.txt plain text: cord-338594-wft7yy6j.txt item: #494 of 549 id: cord-338654-ma9ayu80 author: Eaton, Lisa A. title: Social and behavioral health responses to COVID-19: lessons learned from four decades of an HIV pandemic date: 2020-04-25 words: 3428 flesch: 27 summary: Trump claims public health warnings on covid-19 are a conspiracy against him A reanalysis of a behavioral intervention to prevent incident HIV infections: Including indirect effects in modeling outcomes of Project EXPLORE Stigma and conspiracy beliefs related to preexposure prophylaxis (PrEP) and interest in using PrEP among black and white men and transgender women who have sex with men Sampling hard to reach populations An information-motivation-behavioral skills model of adherence to antiretroviral therapy The novel coronavirus (COVID-2019) outbreak: Amplification of public health consequences by media exposure Stigma: Notes on the management of spoiled identity Advantages and disadvantages for receiving Internet-based HIV/AIDS interventions at home or at community-based organizations The injury iceberg: An ecological approach to planning sustainable community safety interventions A meta-analytic review of HIV behavioral interventions for reducing sexual risk behavior of men who have sex with men Institute of Medicine. These conspiracy-driven messages are all well-documented lines of thought in HIV social science research, and critically, result in harmful outcomes (Nattrass, 2012; Kalichman, 2017) . keywords: community; covid-19; disease; health; hiv; interventions; level; prevention cache: cord-338654-ma9ayu80.txt plain text: cord-338654-ma9ayu80.txt item: #495 of 549 id: cord-338804-nreqluol author: Heise, M.T. title: Viral Pathogenesis date: 2014-11-28 words: 6419 flesch: 22 summary: Though there is evidence that the host immune response exacerbates virus induced disease during both Sindbis virus and VEE infection (Rowell and Griffin, 2002; Kimura and Griffin, 2003; Charles et al., 2001) , in the case of VEE, mice lacking a functional adaptive immune system still succumb to virus-induced disease (Charles et al., 2001) , suggesting the direct cell killing by the virus contributes to disease pathogenesis. These results further reinforce the idea that virus receptor interactions play a crucial role in determining whether the virus can efficiently infect the host and ultimately cause disease. keywords: cell; disease; host; immune; infection; interactions; interferon; type; virus; viruses cache: cord-338804-nreqluol.txt plain text: cord-338804-nreqluol.txt item: #496 of 549 id: cord-339341-c2o42b5j author: Matibag, Gino C. title: Advocacy, promotion and e-learning: Supercourse for zoonosis date: 2005-09-01 words: 5856 flesch: 37 summary: key: cord-339341-c2o42b5j authors: Matibag, Gino C.; Igarashi, Manabu; La Porte, Ron E.; Tamashiro, Hiko title: Advocacy, promotion and e-learning: Supercourse for zoonosis date: 2005-09-01 journal: Environmental Health and Preventive Medicine DOI: 10.1007/bf02897702 sha: doc_id: 339341 cord_uid: c2o42b5j This paper discusses the history of emerging infectious diseases, risk communication and perception, and the Supercourse lectures as means to strengthen the concepts and definition of risk management and global governance of zoonosis. World Health Organization Globalisation of prevention education: a golden lecture Factors in the emergence of infectious diseases Threats to global health and survival; the growing crises of tropical infectious diseasesan unfinished agenda Emerging infectious diseases among indigenous peoples Epidemiology of the plague of Athens The Columbian Exchange: Biological and Cultural Consequences of 1492. keywords: agents; communication; development; diseases; emergence; factors; health; human; infections; information; people; public; risk; supercourse; world cache: cord-339341-c2o42b5j.txt plain text: cord-339341-c2o42b5j.txt item: #497 of 549 id: cord-339796-gccnvh0z author: Zhang, Si Min title: Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins date: 2015-07-31 words: 9101 flesch: 40 summary: Dimerization of anti-viral peptides has been shown to enhance both their structural stability and the number of interaction sites and thus their anti-viral efficacy Precipitated pseudotyped HIV-1 viral particles dissolved in RIPA buffer were also prepared in Laemmli reducing buffer. keywords: anti; cells; entry; env; fig; fusion; gag; gp41; membrane; mper; p24; peptides; protein; residues; sequence; terminal; trp; virus cache: cord-339796-gccnvh0z.txt plain text: cord-339796-gccnvh0z.txt item: #498 of 549 id: cord-339879-92esdjy9 author: Delhalle, Sylvie title: Phages and HIV-1: From Display to Interplay date: 2012-04-13 words: 22095 flesch: 39 summary: The multimerization of human immunodeficiency virus type I Vif protein: A requirement for Vif function in the viral life cycle Potent suppression of viral infectivity by the peptides that inhibit multimerization of human immunodeficiency virus type 1 (HIV-1) Vif proteins An immunodominant neutralization epitope on the -thumb‖ subdomain of human immunodeficiency virus type 1 reverse transcriptase revealed by phage display antibodies A novel neutralization epitope on the -thumb‖ subdomain of human immunodeficiency virus type 1 reverse transcriptase revealed by a monoclonal antibody Recombinant human antibodies against the reverse transcriptase of human immunodeficiency virus type-1 HIV-1 Rev nuclear export signal binding peptides isolated by phage display Measuring cooperative Rev protein-protein interactions on rev responsive RNA by fluorescence resonance energy transfer An intrabody based on a llama single-domain antibody targeting the N-terminal α-helical multimerization domain of HIV-1 Rev prevents viral production Generation and characterization of a chimeric rabbit/human fab for co-crystallization of HIV-1 Rev A peptide inhibitor of HIV-1 assembly in vitro Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41 Small-molecule HIV-1 gp120 inhibitors to prevent HIV-1 entry: An emerging opportunity for drug development Molecular characterization of the circulating anti-HIV-1 gp120-specific b cell repertoire using antibody phage display libraries generated from pre-selected HIV-1 gp120 binding PBLs Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design Binding of glycoprotein 120 and peptides from the HIV-1 envelope by autoantibodies in mice with experimentally induced systemic lupus erythematosus and in patients with the disease Prospects for immunotherapeutic proteolytic antibodies Phosphonate ester probes for proteolytic antibodies Naturally occurring proteolytic antibodies: Selective immunoglobulin m-catalyzed hydrolysis of HIV gp120 Theory of proteolytic antibody occurrence Site-directed mutagenesis of proteolytic antibody light chain Naturally occurring antibodies devoid of light chains Nanobodies(r): New ammunition to battle viruses Mode of action for linear peptide inhibitors of HIV-1 gp120 interactions Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15 The ixodes scapularis salivary protein, Salp15, prevents the association of HIV-1 gp120 and CD4 Natural human antibodies retrieved by phage display libraries from healthy donors: Polyreactivity and recognition of human immunodeficiency virus type 1gp120 epitopes A VH clonal deficit in human immunodeficiency virus-positive individuals reflects a B-cell maturational arrest Selective variations in vivo of VH3 and VH1 gene family expression in peripheral B cell igM, igD and igG during HIV infection Molecular analysis of HIV-1 gp120 antibody response using isotype igM and igG phage display libraries from a long-term non-progressor HIV-1-infected individual Improvement in affinity and HIV-1 neutralization by somatic mutation in the heavy chain first complementarity-determining region of antibodies triggered by HIV-1 infection Cross-reactive human igm-derived monoclonal antibodies that bind to HIV-1 envelope glycoproteins Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies Enfuvirtide: The first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes Identification of D-peptide ligands through mirror-image phage display Protein design of an HIV-1 entry inhibitor Molecular recognition by a binary code Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody Subdomain folding and biological activity of the core structure from human immunodeficiency virus type 1 gp41: A representative sequence from the first group (268.1, HLGPGR), corresponded to the crown of the V3 loop, a linear epitope, while two sequences of the second group (268.2, KAIHRI and 268.3, KSLHRH), showed no homology to linear HIV-1 epitopes. keywords: affinity; antibodies; antibody; binding; ccr5; cd4; display; epitope; et al; fab; gp120; gp41; hiv-1; human; identification; immunodeficiency; libraries; library; loop; mab; mer; motif; peptide; phage; phage display; protein; region; residues; rpl; screening; sequences; specific; type; virus cache: cord-339879-92esdjy9.txt plain text: cord-339879-92esdjy9.txt item: #499 of 549 id: cord-340389-0fybiybv author: Fahrioglu, Umut title: CCR5-Δ32 gene variant frequency in the Turkish Cypriot population date: 2020-07-31 words: 3556 flesch: 55 summary: Abbreviations AIDS, Acquired immunodeficiency syndrome; ART, Antiretroviral therapy; CCR5, C-C motif chemokine receptor 5; CXCR4, C-X-C motif chemokine receptor 4; GPCR, G protein coupled receptor; HIV, Human immunodeficiency virus; M-tropic, Macrophagetropic; TALEN, Transcription activator-like effector nuclease; T-Tropic, T cell tropic; ZFN, Zinc-finger nuclease Distribution of the mutated delta 32 allele of CCR5 co-receptor gene in Iranian population WHO | Data and statistics International Committee on Taxonomy of Viruses (ICTV) Acquired immune deficiency syndrome (AIDS) UNAIDS (2020) Recent UNAIDS reports (December 2019) indicate that 37.9 million people have been affected by HIV infection around the globe in 2018, of which 1.7 million are cited as new infections. keywords: allele; ccr5; cell; cypriot; frequency; hiv; population; receptor; δ32 cache: cord-340389-0fybiybv.txt plain text: cord-340389-0fybiybv.txt item: #500 of 549 id: cord-340489-yo3cp5vs author: None title: KAPITEL 13 Infektionskrankheiten date: 2008-12-31 words: 26587 flesch: 38 summary: ASL spielt in der Diagnostik des rheumatischen Fiebers nur eine geringe Rolle, ADB hat in der Diagnostik der akuten Glomerulonephritis größere Bedeutung. Antikörpernachweisverfahren (Mikroagglutination, ELISA, Westernblot) spielen in der Diagnostik der akuten Enterokolitiden keine wesentliche Rolle. keywords: abb; aber; aids; alle; als; anderen; antibiotika; antikörper; antiretroviralen; antivirale; auch; auch bei; auf; auf der; auftreten; aus; bedeutung; behandelt; behandlung; bei; bei der; bei hiv; beim; bekannt; bereits; besteht; bild; bis; bisher; blut; bzw; cd4; chemotherapie; cmv; daher; damit; dann; das; dass; dem; denen; der; der hiv; der infektion; der therapie; des; deutschland; diagnose; diagnostik; die; diese; dna; durch; durch den; durch die; durchgeführt; ebenfalls; ebv; eine; eingesetzt; einige; erfolgen; erfolgt; erkrankungen; erreger; erwachsenen; evtl; fieber; fällen; führen; führt; für; für die; für eine; gabe; gegen; gibt; haben; hat; hbv; hcv; hemmung; hepatitis; herpesviren; heute; hier; hiv; hoher; hpv; hsv; häufig; ifn; immer; immunsupprimierten; impfstoff; impfung; infektion; infizierten; interferone; ist; ist das; ist der; ist die; ist eine; ist es; jahren; jedoch; kann; kap; kindern; klinischen; kommen; kommt; kommt es; können; lassen; letzten; liegt; lymphozyten; man; maßnahmen; mehr; meist; meisten; menschen; mit; mit der; mit einer; monate; muss; möglich; müssen; nach; nachgewiesen; nachweis; nachweis von; neben; nebenwirkungen; nicht; noch; nukleosidanaloga; nur; nur bei; oder; oft; patienten; pcr; pneumokokken; prionen; prognose; prp; relativ; ribavirin; risiko; rna; rolle; schweren; sehr; sein; seit; selten; sich; sie; sind; sollte; spezifische; substanzen; symptome; tab; tage; therapie; therapie ist; und; und bei; und der; und eine; und mit; unter; untersuchung; verlauf; verschiedene; verursacht; veränderungen; viele; viren; virus; virusvermehrung; von; von der; vor; war; weitere; wenn; werden; werden die; werden können; wie; wird; wochen; wurde; während; z. b.; zahl; zellen; zns; zum; zunächst; zur; zwischen; über; übertragung cache: cord-340489-yo3cp5vs.txt plain text: cord-340489-yo3cp5vs.txt item: #501 of 549 id: cord-340619-3tjquzx8 author: Menghua, Wu title: Case report: one case of coronavirus disease 2019 (COVID-19) in a patient co-infected by HIV with a normal CD4(+) T cell count date: 2020-07-23 words: 1603 flesch: 60 summary: [4] concluded the risk factors of prolonged viral RNA shedding in COVID-19 patients: male sex, delayed admission to hospital after illness onset, and invasive mechanical ventilation. As an epidemic disease, viral shedding duration is the key to disease control. keywords: duration; sars; shedding; viral cache: cord-340619-3tjquzx8.txt plain text: cord-340619-3tjquzx8.txt item: #502 of 549 id: cord-340703-vtuy806l author: Cascio, Antonio title: Low bone mineral density in HIV-positive young Italians and migrants date: 2020-09-03 words: 4494 flesch: 51 summary: In examining the gender in mono-infected HIV patients, the percentages of HIV patients were significantly greater in Italian males in comparison to migrant males (57.6% > 25%, p = 0.007). Our data confirm that early screening for low BMD and other risk factors associated with bone loss in HIV patients is useful keywords: bmd; bone; hiv; itg; low; migrants; osteoporosis; patients; study cache: cord-340703-vtuy806l.txt plain text: cord-340703-vtuy806l.txt item: #503 of 549 id: cord-340763-cxnu9g8y author: Grimm, Sebastian K. title: Directed Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies date: 2015-02-17 words: 7847 flesch: 37 summary: [50] [51] , suggesting that the display of HIV envelope protein is feasible in principle. Therefore, and because of the well-established and characterized Aga1/2-based display system, S. cerevisiae was chosen as host for HIV spike protein display. keywords: antibodies; antibody; binding; cells; display; envelope; fig; gp120; hiv; human; min; mutations; protein; sosip; variants; yeast cache: cord-340763-cxnu9g8y.txt plain text: cord-340763-cxnu9g8y.txt item: #504 of 549 id: cord-340777-d1vwjqk6 author: O’Byrne, Patrick title: Immediate PrEP after PEP: Results from an Observational Nurse-Led PEP2PrEP Study date: 2020-08-28 words: 4869 flesch: 49 summary: 4, 5 The possibility of HIV acquisition in the near future (eg, less than 12-month period) after PEP use has also led the United States Centers for Disease Control and Prevention 4 and the International Antiviral Association (USA Panel) 6 to HIV PrEP is warranted after the use of HIV PEP. First, these results contribute generally to the everexpanding literature on HIV PrEP and more specifically to the sparse literature on PEP2PrEP. keywords: hiv; patients; pep; pep2prep; prep; prophylaxis; use cache: cord-340777-d1vwjqk6.txt plain text: cord-340777-d1vwjqk6.txt item: #505 of 549 id: cord-340879-gu91cact author: Li, Miao title: Isolation and Characterization of a Phaseolus vulgaris Trypsin Inhibitor with Antiproliferative Activity on Leukemia and Lymphoma Cells date: 2017-01-23 words: 4161 flesch: 46 summary: Gold bean trypsin inhibitor is dissimilar from broad bean trypsin inhibitor [9] in that the former lacks HIV-1 reverse transcriptase inhibitory activity. Gold bean trypsin inhibitor is dissimilar from broad bean trypsin inhibitor [9] in that the former lacks HIV-1 reverse transcriptase inhibitory activity. keywords: activity; antifungal; bean; cells; fraction; gel; gold; inhibitor; trypsin; trypsin inhibitor cache: cord-340879-gu91cact.txt plain text: cord-340879-gu91cact.txt item: #506 of 549 id: cord-341097-c96hm610 author: Mayer, Craig S. title: Analysis of data dictionary formats of HIV clinical trials date: 2020-10-05 words: 6901 flesch: 54 summary: To demonstrate some examples of study data elements, Table 1 shows the element data dictionary from study NCT00099359: 'Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission.' We also describe relevant standards for study data dictionaries. keywords: clinical; common; data; dictionaries; dictionary; elements; format; hiv; sharing; studies; study; values cache: cord-341097-c96hm610.txt plain text: cord-341097-c96hm610.txt item: #507 of 549 id: cord-341155-3d64mso0 author: Slots, Jørgen title: Bacterial and viral pathogens in saliva: disease relationship and infectious risk date: 2010-12-07 words: 9342 flesch: 22 summary: Human immunodeficiency virus infection is a potent herpesvirus re-activator, as demonstrated by a strong correlation between decreasing CD4 cell counts in HIV-infected patients and increasing rates of herpesvirus re-activation (34) . Identification of pathogen and host-response markers correlated with periodontal disease Quantitation of hepatitis C virus RNA in saliva and serum of patients coinfected with HCV and human immunodeficiency virus Quantitative determination of CMV-DNA in saliva of patients with bone marrow and stem cell transplantation using TaqMan-PCR Natural history of oral human papillomasvirus infections in female and male partners: a prospective Finnish HPV Family Study Use of throat swab or saliva specimens for detection of respiratory viruses in children The use of PVP-iodine as an adjunct to nonsurgical treatment of chronic periodontitis Quantitative studies on the salivary flora Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines Human papillomavirus in saliva of patients with oral squamous cell carcinoma Periodontitis lesions are the main source of salivary cytomegalovirus Oral viral infections of children Oral mucosal fungal infections Severe acute respiratory syndrome and dentistry: a retrospective view Epstein-Barr virus specific salivary antibodies as related to stress caused by examinations Human cytomegalovirus salivary antibodies as related to stress Academic stress, immunological reaction, and academic performance among students of nursing and physiotherapy Periodontitis lesions are a source of salivary cytomegalovirus and Epstein-Barr virus Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome Microbial testing in periodontics: value, limitations and future directions Investigating the concurrent presence of HCV in serum, oral fluid and urine samples from chronic HCV patients in Faisalabad Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1 The re-emergence of syphilis in the United Kingdom: the new epidemic phases Selection of antimicrobial agents in periodontal therapy Systemic antibiotics in periodontics Oral viral infections of adults Herpesviral-bacterial interactions in periodontal diseases Human viruses in periodontitis Age and sex relationships of superinfecting microorganisms in periodontitis patients Subgingival microflora of advanced periodontitis in the Dominican Republic Actinobacillus actinomycetemcomitans in human periodontal disease: a crosssectional microbiological investigation Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis Oral herpetic infections (HSV 1-8) Chronic herpesvirus reactivation occurs in aging Relationship between Porphyromonas gingivalis, Epstein-Barr virus infection and reactivation in periodontitis Patient with severe periodontitis and subgingival Epstein-Barr virus treated with antiviral therapy Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential Risk of exposure to Legionella in dental practice A longitudinal study of Lancefield group keywords: bacteria; barr; disease; dna; epstein; hepatitis; herpesvirus; hiv; human; individuals; infection; pathogens; patients; periodontitis; risk; saliva; salivary; transmission; virus cache: cord-341155-3d64mso0.txt plain text: cord-341155-3d64mso0.txt item: #508 of 549 id: cord-341298-mqpovrms author: Morse, S.A. title: Viruses and Bioterrorism date: 2016-10-31 words: 4792 flesch: 35 summary: If deployed, FMD virus would have caused the destruction of property and resulted in major economic losses. He was convicted of terrorist activity and money laundering even though he did not have FMD virus in his possession (Keremidis et al., 2013) . keywords: agents; disease; et al; fmd; hiv; human; influenza; laboratory; major; virus; viruses cache: cord-341298-mqpovrms.txt plain text: cord-341298-mqpovrms.txt item: #509 of 549 id: cord-341304-jdvzpvdx author: Pata, Rama Kanth title: Human Immunodeficiency Virus: A Dark Cloud With Silver Lining During the COVID-19 Pandemic date: 2020-07-20 words: 1873 flesch: 46 summary: The leading cause of mortality in COVID-19 patients is acute respiratory distress syndrome (ARDS). Clinical trials have shown varying levels of effectiveness of lopinavir-boosted ritonavir on reducing mortality rates in COVID-19 patients. keywords: coronavirus; covid-19; days; hiv; patients cache: cord-341304-jdvzpvdx.txt plain text: cord-341304-jdvzpvdx.txt item: #510 of 549 id: cord-341323-mw352rr1 author: Logie, Carmen H title: Lessons learned from HIV can inform our approach to COVID‐19 stigma date: 2020-05-04 words: 1562 flesch: 48 summary: Experts offer ethical guidance Fair Allocation of Scarce Medical Resources in the Time of Covid-19 Community-based interventions that work to reduce HIV stigma and discrimination: results of an evaluation study in Thailand Stigma in health facilities: why it matters and how we can change it Combating HIV stigma in health care settings: what works? We can leverage our four decades of HIV research to understand and address COVID-19 stigma. keywords: covid-19; health; hiv; persons; stigma cache: cord-341323-mw352rr1.txt plain text: cord-341323-mw352rr1.txt item: #511 of 549 id: cord-341503-3cvtoc2j author: Jaiswal, J. title: Disinformation, Misinformation and Inequality-Driven Mistrust in the Time of COVID-19: Lessons Unlearned from AIDS Denialism date: 2020-05-21 words: 2556 flesch: 27 summary: USA Today Tuskegee always looms in our minds: some fear black Americans, hardest hit by coronavirus, may not get vaccine Study: nearly a third of Americans believe a conspiracy theory about the origins of the coronavirus Medical apartheid: the dark history of medical experimentation on black Americans from colonial times to the present Ubiquitous yet unclear: a systematic review of medical mistrust Medical mistrust and PrEP perceptions among transgender women: a cluster analysis The association of cultural and structural factors with perceived medical mistrust among young adult Latinos in rural Oregon Medical mistrust, racism, and delays in preventive health screening among African-American men Does discrimination breed mistrust? Much of the evidence needed to fully inform clinical and public health responses is not yet available, making COVID-19 uniquely vulnerable to a proliferation of disinformation, misinformation, and medical mistrust, including what are often called conspiracy beliefs [6, 7] . keywords: beliefs; conspiracy; covid-19; disinformation; health; hiv; mistrust cache: cord-341503-3cvtoc2j.txt plain text: cord-341503-3cvtoc2j.txt item: #512 of 549 id: cord-341838-lkz8ro90 author: Gervasoni, Cristina title: Clinical features and outcomes of HIV patients with coronavirus disease 2019 date: 2020-05-14 words: 1796 flesch: 43 summary: key: cord-341838-lkz8ro90 authors: Gervasoni, Cristina; Meraviglia, Paola; Riva, Agostino; Giacomelli, Andrea; Oreni, Letizia; Minisci, Davide; Atzori, Chiara; Ridolfo, Annalisa; Cattaneo, Dario title: Clinical features and outcomes of HIV patients with coronavirus disease 2019 date: 2020-05-14 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa579 sha: doc_id: 341838 cord_uid: lkz8ro90 Little is known about the clinical outcomes of HIV patients infected with SARS-CoV-2. [5] [6] [7] Treated people living with HIV who have a normal CD4 T cell count and suppressed viral load may not be at increased risk of serious illness, but many also have other conditions that increase their overall risk: almost half of HIV patients are males, aged >50 years, and affected by chronic cardiovascular and lung diseases. keywords: hiv; patients; sars cache: cord-341838-lkz8ro90.txt plain text: cord-341838-lkz8ro90.txt item: #513 of 549 id: cord-342076-3a6aky7i author: Zhang, Lei title: Describing the Chinese HIV Surveillance System and the Influences of Political Structures and Social Stigma date: 2012-09-07 words: 3999 flesch: 41 summary: An evaluation of HIV surveillance systems by Loo et al., indicated that although the Chinese HIV surveillance system obtained high scores for flexibility and timeliness across in its surveillance activities, representativeness and completeness of data are poor in its case reporting [34] . China CDC & National Sentinel Surveillance Group Injection drug use and HIV/AIDS transmission in China Systematic review of HIV and HCV infection among drug users in China Situations and trends of HIV and syphilis infections among drug users in China Surveillance of AIDS among female sex workers in China Improving HIV surveillance systems: Country experiences and a proposal for evaluation framework Quantitatively monitoring AIDS policy implementation in China Living with HIV/AIDS in China Policy Implementation in Post-Mao China The SARS Epidemic and its Aftermath in China: A Political Perspective Evaluation of the Guangdong HIV/AIDS surveillance system, China Building a Better Infectious Disease Surveillance System for China: An evaluation from a political perspective Discrimination against people with HIV persists in China Disclosure of HIV status: cultural issues of Asian patients Disclosure of HIV status is a family matter: field notes from China Help-seeking in a context of AIDS stigma: understanding the healthcare needs of people with HIV/AIDS in China HIV/STD stigmatization fears as health-seeking barriers in China The China Stigma Index Report Evaluation of effect of community-based HIV/AIDS interventions among men who have sex with men in eighteen cities, China Which Chinese men who have sex with men miss out on HIV testing? Investigation on the Infection of HIV, HCV, Syphilis and HBV among MSM in Dalian City in 2008 Possible increase in HIV and syphilis prevalence among men who have sex with men in Guangzhou, China: results from a respondent-driven sampling survey Surveillance on the high risk behaviors among 239 men who have sex with men Prevalence and correlates of HIV and syphilis infections among men who have sex with men in Chongqing Municipality Survey of the knowledge, attitude, and practice on aids among MSM population in Urumchi The next era of HIV in China: rapidly spreading epidemics among men who have sex with men The authors confirm that this article content has no conflicts of interest. keywords: aids; china; data; health; hiv; information; men; reporting; surveillance; system cache: cord-342076-3a6aky7i.txt plain text: cord-342076-3a6aky7i.txt item: #514 of 549 id: cord-342719-bdxb45us author: Yamamoto, Shinya title: Antibody Response to SARS-CoV-2 in people living with HIV date: 2020-10-02 words: 409 flesch: 52 summary: Antibody profiles in mild and severe cases of COVID-19 Undetectable plasma HIV RNA load predicts success after hepatitis B vaccination in HIV-infected persons One case of coronavirus disease 2019 (COVID-19) in a patient co-infected by HIV with a low CD4(+) T-cell count The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression Antibody Responses to SARS-CoV-2 at 8 weeks postinfection in asymptomatic patients. Therefore, uncontrolled HIV infection may be a factor to lower the rate of seroconversion, including false negative. keywords: hiv; patients cache: cord-342719-bdxb45us.txt plain text: cord-342719-bdxb45us.txt item: #515 of 549 id: cord-342936-43u7afl3 author: Balzarini, Jan title: Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy date: 2007 words: 11336 flesch: 37 summary: Implications for multivalent ligand recognition An extensive and detailed overview of carbohydrate-binding proteins that interact with the HIV Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR Insights into carbohydrate recognition by Narcissus pseudonarcissus lectin: the crystal structure at 2 Å resolution in complex with α1-3 mannobiose Strucure of mannose-specific snowdrop (Galanthus nivalis) lectin is representative of a new plant lectin family A novel tetrameric lectin from Lycoris aurea with four mannose binding sites per monomer Mutational pathways, resistance profile, and side effects of Cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes Role of envelope glycoprotein carbohydrate in human immunodeficiency virus (HIV-1) infectivity and virus-induced cell fusion Sugar-binding proteins potently inhibit dendritic cell human immunodeficiency virus type 1 (HIV-1) infection and dendritic-cell-directed HIV-1 transfer Inhibition of HIV entry by carbohydratebinding proteins Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIVHIV-1-1 DC-SIGN: escape mechanism for pathogens Anti-human immunodeficiency virus (HIV-1) microbicide drug candidates to prevent HIV infection Maturation of blood derived dendritic cells enhances HIV-1 capture and transmission Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN CD4 co-expression regulates DC-SIGNmediated transmission of human immunodeficiency virus type 1 Langerin is a natural barrier to HIV-1 transmission by Langerhans cells Antibody domain exchange is an immunological solution to carbohydrate cluster recognition Glycobiology at Oxford. Structure analysis of refined complexes at 2.3 Å and 3.0 Å resolution Crystal structures of Urtica dioica agglutinin and its complex with triacetylchitotriose -3)-and α-(1-6)-D-mannosespecific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro The mannose-specific plant lectins from Cymbidium hybrid and Epi pactis helleborine and the (N-acetylglucosamine) n -specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV gp120. keywords: antiviral; binding; carbohydrate; cbas; cell; envelope; glycans; glycosylation; gp120; hiv; immunodeficiency; infection; lectin; mannose; pathogen; protein; sign; strains; type; virus cache: cord-342936-43u7afl3.txt plain text: cord-342936-43u7afl3.txt item: #516 of 549 id: cord-343470-w215pzdc author: Tsai, Kevin title: Epigenetic and epitranscriptomic regulation of viral replication date: 2020-06-12 words: 9796 flesch: 31 summary: Whereas cellular gene expression may be either enhanced or inhibited by specific epigenetic modifications deposited on histones (in particular, histone H3), these epigenetic modifications can also repress viral gene expression, potentially functioning as a potent antiviral innate immune response in DNA virus-infected cells. By contrast, the various covalent modifications added to RNAs, termed epitranscriptomic modifications, can positively regulate mRNA translation and/or stability, and both DNA and RNA viruses have evolved to utilize epitranscriptomic modifications as a means to maximize viral gene expression. keywords: cells; chromatin; dna; expression; gene; histone; host; ifi16; infection; modifications; pml; proteins; replication; residues; rna; virus; viruses cache: cord-343470-w215pzdc.txt plain text: cord-343470-w215pzdc.txt item: #517 of 549 id: cord-344084-z4t2wkgk author: Ellwanger, Joel Henrique title: Beyond HIV infection: neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases date: 2020-05-30 words: 15779 flesch: 32 summary: Besides, the regulation of multiple aspects of the immune system is strongly influenced by EVs (O'Neill and Quah, 2008; Colombo et al., 2014; Ellwanger et al., 2016) . This knowledge gap should be addressed in further studies since the reemergence of ROCV in Brazil is a concern in terms of public health (Figueiredo, 2007; Ellwanger et al., 2017b) . keywords: allele; association; ccr5; ccr5δ32; cells; chemokine; disease; encephalitis; et al; expression; gene; hcv; hepatitis; hiv; host; human; immune; individuals; infected; infection; influenza; patients; receptor; role; studies; study; susceptibility; virus; virus infection; wnv cache: cord-344084-z4t2wkgk.txt plain text: cord-344084-z4t2wkgk.txt item: #518 of 549 id: cord-345342-04tvuj9f author: Kumar, Rebecca N. title: COVID‐19 in an HIV‐positive Kidney Transplant Recipient date: 2020-05-26 words: 1452 flesch: 42 summary: Unlike the case series from Spain where HIV patients with COVID-19 changed regimens to include a boosted protease inhibitor, no modifications were made to our patient's ART regimen 6 . We also present a review of COVID‐19 cases in kidney transplant recipients. keywords: covid-19; hiv; kidney; patient; transplant cache: cord-345342-04tvuj9f.txt plain text: cord-345342-04tvuj9f.txt item: #519 of 549 id: cord-345771-3v2avxiv author: Traub, Ariana Moriah title: Multimonth Dispensing of Antiretroviral Therapy Protects the Most Vulnerable From 2 Pandemics at Once date: 2020-06-30 words: 709 flesch: 45 summary: As a key strategy to safeguard patients and health care workers providing HIV services, MMD also reduces clinic visits, improves viral suppression, encourages social distancing, and potentially saves patients from the dual threat of SARS-CoV-2 and HIV. Thus, policy makers-including the U.S. President's Emergency Plan for AIDS Relief-are encouraging countries to provide PLHIV with a multimonth supply of ART as a key strategy to safeguard PLHIV and health care workers involved in providing HIV services. keywords: countries; hiv; plhiv cache: cord-345771-3v2avxiv.txt plain text: cord-345771-3v2avxiv.txt item: #520 of 549 id: cord-346153-9162w7il author: Openshaw, P J title: Crossing barriers: infections of the lung and the gut date: 2008-12-24 words: 1718 flesch: 36 summary: 9 Although dual tropism for both the lung and gut may be an obvious and clear reason to consider the gut in respiratory infection, links can also be more subtle and complex. It has been known for many years that healthy people o en carry pathogenic bacteria (such as Neisseria meningitides or Streptococcus pneumoniae ) in the upper respiratory tract, but may only develop invasive disease during coinfection with respiratory viruses. keywords: coronavirus; gut; infection; sars; symptoms cache: cord-346153-9162w7il.txt plain text: cord-346153-9162w7il.txt item: #521 of 549 id: cord-346314-o9fjpqaj author: Jarboui, Mohamed Ali title: Nucleolar Protein Trafficking in Response to HIV-1 Tat: Rewiring the Nucleolus date: 2012-11-15 words: 10059 flesch: 29 summary: The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms Oncogenic activity of MCM7 transforming cluster Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion The XRCC genes: expanding roles in DNA double-strand break repair Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cells Identification of cellular cofactors for human immunodeficiency virus replication via a ribozyme-based genomics approach siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration The dynamics of HMG proteinchromatin interactions in living cells Retroviral cDNA integration: stimulation by HMG I family proteins HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro Activity of the human immunodeficiency virus type 1 cell cycle-dependent internal ribosomal entry site is modulated by IRES trans-acting factors Fuel feeds function: energy metabolism and the T-cell response Human immunodeficiency virus type 1, human protein interaction database at NCBI Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystems The biological context of HIV-1 host interactions reveals subtle insights into a system hijack HIVhost interactions: a map of viral perturbation of the host system Cataloguing the HIV type 1 human protein interaction network Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication Dual role of host cell factors in HIV-1 replication: restriction and enhancement of the viral cycle Decoding the multifaceted HIV-1 virus-host interactome Functions of Tat: the versatile protein of human immunodeficiency virus type 1 Chromatin dynamics associated with HIV-1 Tat-activated transcription Modifications in host cell cytoskeleton structure and function mediated by intracellular HIV-1 Tat protein are greatly dependent on the second coding exon Pathway analysis in HEK 293T cells overexpressing HIV-1 tat and nucleocapsid Expression profiles and pathway analysis in HEK 293 T cells overexpressing HIV-1 Tat and nucleocapsid using cDNA microarray Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes Proteomics analysis of human astrocytes expressing the HIV protein Tat HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression Cell-type-specific proteome and interactome: using HIV-1 Tat as a test case Differentially expressed genes in HIV-1 tat-expressing CD4(+) T-cell line HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription Genome-wide binding map of the HIV-1 Tat protein to the human genome Jurkat T cells and development of the T-cell receptor signalling paradigm Global survey of human T leukemic cells by integrating proteomics and transcriptomics profiling A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity DEDD and DEDD2 associate with caspase-8/10 and signal cell death Chaperones and multitasking proteins in the nucleolus: networking together for survival? Protein B23 is an important human factor for the nucleolar localization of the human immunodeficiency virus protein Tat Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element Effects of a highly basic region of human immunodeficiency virus Tat protein on nucleolar localization A region of basic amino-acid cluster in HIV-1 Tat protein is essential for trans-acting activity and nucleolar localization Intracellular trafficking and interactions of the HIV-1 Tat protein Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells The ins and outs of HIV-1 Tat Tuning the transport properties of HIV-1 Tat arginine-rich motif in living cells In vivo study of HIV-1 Tat arginine-rich motif unveils its transport properties Direct interaction of the human I-mfa domain-containing protein Tat results in cytoplasmic sequestration and control of Tat activity The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin betadependent nuclear localization signals The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties Global enhancement of nuclear localization-dependent nuclear transport in transformed cells Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors The ins and outs of HIV Rev The HIV-1 Rev protein The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function Mechanisms of receptor-mediated nuclear import and nuclear export The nuclear pore component Nup358 promotes transportin-dependent nuclear import A nucleolar TAR decoy inhibitor of HIV-1 replication Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector Gautier VW Proteomic profiling of the human T-cell nucleolus keywords: abundance; analysis; anti; cells; enrichment; expression; figure; fold; gene; human; jurkat; nuclear; nucleolar; nucleolus; pathway; proteins; replication; ribosomal; rna; tap; tat; tat expression; tat protein; virus cache: cord-346314-o9fjpqaj.txt plain text: cord-346314-o9fjpqaj.txt item: #522 of 549 id: cord-346424-gfccstoz author: Friedrich, Brian M title: A Functional Role for ADAM10 in Human Immunodeficiency Virus Type-1 Replication date: 2011-05-11 words: 6366 flesch: 39 summary: Silencing ADAM10 expression with small interfering RNA (siRNA) 48 hours before infection significantly inhibited HIV-1 replication in primary human monocyte-derived macrophages and in CD4(+ )cell lines. In agreement, ADAM10 over-expression significantly increased HIV-1 replication. keywords: adam10; cells; domain; expression; figure; gene; hiv; infection; ltr; macrophages; metalloprotease; nuclear; replication; role; secretase; sirna; virus cache: cord-346424-gfccstoz.txt plain text: cord-346424-gfccstoz.txt item: #523 of 549 id: cord-346557-s6c7d70y author: Brennan, David J. title: How Might Social Distancing Impact Gay, Bisexual, Queer, Trans and Two-Spirit Men in Canada? date: 2020-04-30 words: 1805 flesch: 43 summary: For instance, the Hassle Free Clinic, a Toronto STI and HIV testing clinic provides services to GBQT2+ clients, has significantly reduced hours, removed clinic drop-in services, and stopped providing routine STI/HIV testing amid the pandemic [15] . Mental health and the COVID-19 pandemic Men's sexual orientation and health in Canada Number of psychosocial strengths predicts reduced HIV sexual risk behaviors above and beyond syndemic problems among gay and bisexual men Sexual orientation and mental health How to date online in the age of COVID-19. keywords: covid-19; gbqt2; health; sex cache: cord-346557-s6c7d70y.txt plain text: cord-346557-s6c7d70y.txt item: #524 of 549 id: cord-347356-uc9dqhyq author: Cooper, TJ title: Coronavirus disease 2019 (COVID‐19) outcomes in HIV/AIDS patients: a systematic review date: 2020-07-15 words: 3953 flesch: 51 summary: We define controlled HIV infection as an undetectable viral load and a CD4 count ≥ 200 cells/lL. A comprehensive literature search was carried out in Global Health, SCOPUS, Medline and EMBASE to identify articles that discussed HIV-positive patients and the clinical implications of HIV infection in COVID-19 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines [13] . Event background COVID-19 COVID-19 and Multiorgan Response Covid-19: risk factors for severe disease and death Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis Rethinking high-risk groups in COVID-19 Undetectable = untransmittable and your health: the personal benefits of early and continuous therapy for HIV infection Global statistics Partners of people on ART -a new evaluation of the risks (The PARTNER Study): design and methods multicentre, prospective, observational study ART in HIV-positive persons with low pretreatment viremia: results from the START trial SARS-CoV-2 and HIV Interim guidance for COVID-19 and persons with HIV COVID-19 and persons with HIV Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement Study Quality Assessment Tools Encephalopathy and seizure activity in a COVID-19 well controlled HIV patient The reflection on an AIDS patient with asymptomatic COVID-19 -abstract -Europe PMC COVID-19 in patients with HIV: clinical case series COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Outcomes among HIV-positive patients hospitalized with COVID-19 HIV-associated pneumocystis pneumonia Case report: one case of coronavirus desease 2019(COVID-19) in patient co-Nfected by HIV with a low CD4+ T cell count Community-acquired bacterial pneumonia in adult HIVinfected patients Global strategies to prevent bacterial pneumonia in adults with HIV disease Severe bacterial nonaids infections in HIV-positive persons: incidence rates and risk factors Bacterial pneumonia, HIV therapy, and disease progression among HIV-infected women in the HIV epidemiologic research (HER) study Mortality and causes of death in people diagnosed with HIV in the era of highly active antiretroviral therapy compared with the general population: an analysis of a national observational cohort COVID-19) and HIV -update from the British HIV Association (BHIVA) keywords: covid-19; hiv; infection; outcomes; patients; plhiv; risk; sars cache: cord-347356-uc9dqhyq.txt plain text: cord-347356-uc9dqhyq.txt item: #525 of 549 id: cord-347710-ff64y6ef author: Wan, Qianya title: Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development date: 2020-07-13 words: 36727 flesch: 38 summary: First, Hsp90 works as a classic chaperone protein to stabilize virus proteins. 57, 473 Except for promoting viral protein translation by binding with the viral IRES sequence, hnRNPs can directly bind with virus proteins to facilitate virus replication. keywords: a71; activation; activity; antiviral; apoptosis; atp; binding; c virus; cells; chaperone; complex; diseases; dna; domain; entry; expression; factor; family; folding; formation; function; gene; hbv; hcv; heat; heat shock; hepatitis; hnrnp; hnrnp a1; host; hsc70; hsp27; hsp90; human; infection; influenza; influenza virus; inhibitors; interaction; kinase; mrna; nuclear; nucleus; polymerase; protein; response; rna; role; shock protein; splicing; stress; terminal; transcription; translation; type; viral; virus; virus infection; virus replication; virus rna; virus type; viruses cache: cord-347710-ff64y6ef.txt plain text: cord-347710-ff64y6ef.txt item: #526 of 549 id: cord-347992-coby2m6e author: Marton, Soledad title: In Vitro and Ex Vivo Selection Procedures for Identifying Potentially Therapeutic DNA and RNA Molecules date: 2010-06-28 words: 10046 flesch: 39 summary: It has been shown that an antagonist RNA aptamer against CTLA-4, a negative regulator of T-cell activation, inhibits its function [101] , while an agonistic aptamer against 4-1BB, a major co-stimulatory receptor, leads to the activation of T cells RNA aptamers have been selected against different viral enzymes and proteins involved in host-cell interactions, such as HIV-1 reverse transcriptase (RT), HIV-1 glycoprotein 120, HCV RNA-dependent RNA polymerase (RdRp), SARS coronavirus NTPase/helicase, and the hemagglutinin protein of human influenza virus B, all of which show efficient viral inhibition [138] keywords: acids; activity; anti; aptamer; binding; cells; dna; factor; growth; hcv; human; inhibition; molecules; protein; receptor; rna; rna aptamers; selection; specific; target; therapeutic; tumor; vitro; vivo cache: cord-347992-coby2m6e.txt plain text: cord-347992-coby2m6e.txt item: #527 of 549 id: cord-348409-oxjd263z author: Stern, Zachariah title: The development of inovirus-associated vector vaccines using phage-display technologies date: 2019-09-08 words: 6052 flesch: 35 summary: X-ray diffraction studies of filamentous bacteriophage M13 at 7 A resolution Chemical modification of the coat protein in bacteriophage fd and orientation of the virion during assembly and disassembly Bacteriophage f1 infection: fate of the parental major coat protein The fate of the protein component of bacteriophage fd during infection Detection of prokaryotic signal peptidase in an Escherichia coli membrane fraction: endoproteolytic cleavage of nascent f1 pre-coat protein Isolation of mutants in M13 coat protein that affect its synthesis, processing, and assembly into phage Conserved residues of the leader peptide are essential for cleavage by leader peptidase Filamentous phage are released from the bacterial membrane by a two-step mechanism involving a short C-terminal fragment of pIII Architectural insight into inovirus-associated vectors (IAVs) and development of IAV-based vaccines inducing humoral and cellular responses: implications in HIV-1 vaccines A detailed review of the architecture of inoviruses and major inovirus-associated vectors (IAVs) and related vaccines Libraries of peptides and proteins displayed on filamentous phage Phage Display • An early overview of the phage-display and its applications Eliminating helper phage from phage display Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase Phage display of cDNA repertoires: the pVI display system and its applications for the selection of immunogenic ligands Surface expression and ligand-based selection of cDNAs fused to filamentous phage gene VI Multivalent display system on filamentous bacteriophage pVII minor coat protein Membrane insertion and assembly of epitopetagged gp9 at the tip of the M13 phage Next generation phage display by use of pVII and pIX as display scaffolds Phage display: concept, innovations, applications and future Vaccination with cetuximab mimotopes and biological properties of induced anti-epidermal growth factor receptor antibodies Identification and characterization of protective epitope of Trichinella spiralis paramyosin Mimotopes selected with neutralizing antibodies against multiple subtypes of influenza A Induction of humoral immune response against Plasmodium falciparum sporozoites by immunization with a synthetic peptide mimotope whose sequence was derived from screening a filamentous phage epitope library High-molecular-weight melanoma-associated antigen mimotope immunizations induce antibodies recognizing melanoma cells Differential immunogenicity of two peptides isolated by high molecular weight-melanoma-associated antigen-specific monoclonal antibodies with different affinities Vaccination with a human high molecular weight melanoma-associated antigen mimotope induces a humoral response inhibiting melanoma cell growth in vitro Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects Specificity of mimotopeinduced anti-high molecular weight-melanoma associated antigen (HMW-MAA) antibodies does not ensure biological activity A mimotope peptide-based anti-cancer vaccine selected by BAT monoclonal antibody Peptide mimotopes recognized by antibodies cetuximab and matuzumab induce a functionally equivalent anti-EGFR immune response Mimotope vaccination for epitope-specific induction of anti-VEGF antibodies Peptide mimics of the group B meningococcal capsule induce bactericidal and protective antibodies after immunization Peptides selected from a phage display library with an HIV-neutralizing antibody elicit antibodies to HIV gp120 in rabbits, but not to the same epitope Protective immune responses induced by the immunization of mice with a recombinant bacteriophage displaying an epitope of the human respiratory syncytial virus Immunisation with phage displaying peptides representing single epitopes of the glycoprotein G can give rise to partial protective immunity to HSV-2 Characterization of murine coronavirus neutralization epitopes with phage-displayed peptides Prophylactic vaccination with phagedisplayed epitope of C. albicans elicits protective immune responses against systemic candidiasis in C57BL/6 mice Protective immune responses against systemic candidiasis mediated by phage-displayed specific epitope of Candida albicans heat shock protein 90 in C57BL/6J mice Recombinant bacteriophage-based multiepitope vaccine against Taenia solium pig cysticercosis Schistosoma japonicum: isolation and identification of peptides mimicking ferritin epitopes from phage display library Protective immunity induced by phage displayed mitochondrial related peptides of Schistosoma japonicum Induction of immunity in sheep to Fasciola hepatica with mimotopes of cathepsin L selected from a phage display library Trichinella spiralis: characterization of phagedisplayed specific epitopes and their protective immunity in BALB/ c mice Identification of HIV vaccine candidate peptides by screening random phage epitope libraries Identification and characterization of a peptide that specifically binds the human, broadly neutralizing anti-human immunodeficiency virus type 1 antibody b12 Immunogenicity of HIV type 1 gp120 CD4 binding site phage mimotopes A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120 Constrained peptide models from phage display libraries highlighting the cognate epitope-specific potential of the anti-HIV-1 mAb 2F5 Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1-positive sera Collection of phage-peptide probes for HIV-1 immunodominant loop-epitope Mimotopes selected with antibodies from HIV-1-neutralizing long-term non-progressor plasma HIV-1 V3 loop crown epitope-focused mimotope selection by patient serum from random phage display libraries: implications for the epitope structural features Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes Variable epitope library-based vaccines: shooting moving targets Variable epitope libraries: new vaccine immunogens capable of inducing broad human immunodeficiency virus type 1-neutralizing antibody response A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera Induction of hepatitis B virus-specific cytotoxic T lymphocytes response in vivo by filamentous phage display vaccine Phage display for sitespecific immunization and characterization of high-risk human papillomavirus specific E7 monoclonal antibodies Peptide mimotopes of rabies virus glycoprotein with immunogenic activity Immunogenicity and epitope mapping of foreign sequences via genetically engineered filamentous phage Multiple display of foreign peptides on a filamentous bacteriophage. Peptides from plasmodium falciparum circumsporozoite protein as antigens Random-peptide libraries and antigenfragment libraries for epitope mapping and the development of vaccines and diagnostics Developing strategies to enhance and focus humoral immune responses using filamentous phage as a model antigen Phage display of peptide epitopes from HIV-1 elicits strong cytolytic responses Inexpensive anticysticercosis vaccine: s3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model Phage display particles expressing tumor-specific antigens induce preventive and therapeutic antitumor immunity in murine p815 model A filamentous bacteriophage targeted to carcinoembryonic antigen induces tumor regression in mouse models of colorectal cancer Active immunization against Alzheimer's beta-amyloid peptide using phage display technology Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration Reduction of betaamyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization EFRH-phage immunization of Alzheimer's disease animal model improves behavioral performance in Morris water maze trials HIV-1 vaccine strategies utilizing viral vectors including antigen-displayed inoviral vectors HIV-1 neutralizing antibodies: understanding nature's pathways Antibodies in HIV-1 vaccine development and therapy Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine Immune clearance of highly pathogenic SIV infection Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes Specific phospholipid recognition by human immunodeficiency virus type-1 neutralizing anti-gp41 2F5 antibody The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1->2 mannose residues on the outer face of gp120 Antibody polyspecificity and neutralization of HIV-1: a hypothesis Immunocontraception: filamentous bacteriophage as a platform for vaccine development The Nobel Prize in chemistry keywords: antibodies; development; diseases; display; epitope; iavs; inovirus; peptide; phage; proteins; studies; vaccines; viruses cache: cord-348409-oxjd263z.txt plain text: cord-348409-oxjd263z.txt item: #528 of 549 id: cord-349104-p0egfpx9 author: Modi, Anita R. title: Coronavirus disease 2019 in an orthotopic liver transplant recipient living with human immunodeficiency virus date: 2020-06-17 words: 1210 flesch: 27 summary: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice COVID-19 in solid organ transplant recipients: initial report from the US Epicenter COVID-19 and kidney transplant patients COVID-19 in long-term liver transplant patients: preliminary experience from an italian transplant center in Lombardy COVID-19 in Patients with HIV: Clinical Case Series Outcomes of Kidney Transplantation in HIV-infected Recipients COVID-19 Illness in Native and Immunosuppressed States: A Clinical-Therapeutic Staging Proposal Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Observational study of hydroxychloroquine in hospitalized patients with COVID-19 Coronavirus disease 2019 in an orthotopic liver transplant recipient living with human immunodeficiency virus Yet immunocompromised status alone, in the absence of other comorbidities, may not necessarily predict severe illness presentations and poorer clinical outcomes as indicated by recent reports of COVID‐19‐infected solid organ transplant recipients and people living with human immunodeficiency virus (HIV). keywords: covid-19; hiv; liver; transplant cache: cord-349104-p0egfpx9.txt plain text: cord-349104-p0egfpx9.txt item: #529 of 549 id: cord-349358-leicos9j author: Ketzinel‐Gilad, Mali title: RNA interference for antiviral therapy date: 2006-06-16 words: 12748 flesch: 38 summary: siRNAs targeting the SARS-CoV RNA polymerase gene inhibited viral RNA replication, protein synthesis and reduced the viral cytopathic effects on Vero cells [36] . A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1 RNA interference of HIV replication Lentivirus-mediated RNA interference of DC-SIGN expression inhibits human immunodeficiency virus transmission from dendritic cells to T cells Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5 Inhibition of respiratory viruses by nasally administered siRNA The promise of siRNAs for the treatment of influenza Inhibition of coxsackievirus B3 replication by small interfering RNAs requires perfect sequence match in the central region of the viral positive strand Inhibition of SARS-CoV replication by siRNA Actively replicating West Nile virus is resistant to cytoplasmic delivery of siRNA Use of RNA interference to prevent lethal murine West Nile virus infection An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection Small interfering RNA inhibits hepatitis B virus replication in mice Short interfering RNA-directed inhibition of hepatitis B virus replication Inhibition of HBV replication by siRNA in a stable HBV-producing cell line Inhibition of hepatitis B virus expression and replication by RNA interference Inhibition of hepatitis B virus in mice by RNA interference Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs Knock-down of hepatitis B virus X protein reduces the tumorigenicity of hepatocellular carcinoma cells Genomic analysis of anti-hepatitis B virus (HBV) activity by small interfering RNA and lamivudine in stable HBV-producing cells Small hairpin RNAs efficiently inhibit hepatitis C IRES-mediated gene expression in human tissue culture cells and a mouse model Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencing HIV-1 nef suppression by virally encoded microRNA Regulation of human immunodeficiency virus 1 transcription by nef microRNA Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1 Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed RNA silencing as a plant immune system against viruses Induction and suppression of RNA silencing by an animal virus Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing Adenosine kinase inhibition and suppression of RNA silencing by geminivirus AL2 and L2 proteins Effects and side-effects of viral RNA silencing suppressors on short RNAs The coat protein of turnip crinkle virus suppresses posttranscriptional gene silencing at an early initiation step A viral protein inhibits the long range signaling activity of the gene silencing signal A viral protein suppresses RNA silencing and binds silencing-generated, 21-to 25-nucleotide double-stranded RNAs Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction Suppression of posttranscriptional gene silencing by a plant viral protein localized in the nucleus Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing A virus-encoded inhibitor that blocks RNA interference in mammalian cells Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis Suppression of RNA interference by adenovirus virus-associated RNA Human immunodeficiency virus type 1 escapes from RNA interferencemediated inhibition Human immunodeficiency virus type 1 escape from RNA interference Hepatitis C virus replicons escape RNA interference induced by a short interfering RNA directed against the NS5b coding region Inhibition of hepatitis B virus gene expression by single and dual small interfering RNA treatment Expression profiling reveals off-target gene regulation by RNAi Activation of the interferon system by short-interfering RNAs Cationic liposome-mediated delivery of siRNAs in adult mice Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3 Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA A system for stable expression of short interfering RNAs in mammalian cells Determinants of interferon-stimulated gene induction by RNAi vectors An enhanced U6 promoter for synthesis of short hairpin RNA Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAimediated gene silencing in the cytoplasm of human cells Promoter choice affects the potency of HIV-1 specific RNA interference Development and application of siRNA expression vector Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference Short-term cytotoxic effects and longterm instability of RNAi delivered using lentiviral vectors Efficient delivery of siRNA for inhibition of gene expression in postnatal mice RNA interference in mammalian cells by chemically-modified RNA RNA interference targeting Fas protects mice from fulminant hepatitis In vivo activity of nuclease-resistant siRNAs Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate siRNA function in RNAi: a chemical modification analysis Functional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interference Challenges for RNAi in vivo Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication siRNA relieves chronic neuropathic pain Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs Inhibition of influenza virus production in virus-infected mice by RNA interference Protection against lethal influenza virus challenge by RNA interference in vivo Atelocollagenmediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer Recombinant viral capsids as an efficient vehicle of oligonucleotide delivery into cells Adenovirus vectormediated doxycycline-inducible RNA interference Conditionally replicating adenoviruses expressing short hairpin RNAs silence the expression of a target gene in cancer cells Inducible, reversible, and stable RNA interference in mammalian cells Cre-lox-regulated conditional RNA interference from transgenes CRE recombinase-inducible RNA interference mediated by lentiviral vectors Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia First Parkinson gene therapy trial launches Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide Antisense oligonucleotides: promise and reality LNA: a versatile tool for therapeutics and genomics Rational siRNA design for RNA interference Asymmetry in the assembly of the RNAi enzyme complex Functional siRNAs and miRNAs exhibit strand bias Attenuation of SARS coronavirus by a short hairpin RNA expression plasmid targeting RNAdependent RNA polymerase Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque RNA interference targeting VP1 inhibits foot-and-mouth disease virus replication in BHK-21 cells and suckling mice Small interfering RNA molecules as potential anti-human rhinovirus agents: in vitro potency, specificity, and mechanism Susceptibility of human hepatitis delta virus RNAs to small interfering RNA action RNA interference against enterovirus 71 infection Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins Expression of small hairpin RNA by lentivirus-based vector confers efficient and stable gene-suppression of HIV-1 on human cells including primary non-dividing cells Inhibition of HIV-1 by lentiviral vector-transduced siRNAs in T lymphocytes differentiated in SCID-hu mice and CD34+ progenitor cellderived macrophages Efficient gene transfer of HIV-1-specific short hairpin RNA into human lymphocytic cells using recombinant adeno-associated virus vectors Inhibition of virus production in JC virus-infected cells by postinfection RNA interference Inhibition of the Epstein-Barr virus lytic cycle by Zta-targeted RNA interference Selective inhibition of hepatitis B virus replication by RNA interference Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes keywords: cells; delivery; effect; expression; gene; hcv; hepatitis; hiv; human; infection; inhibition; interference; replication; rna; rna interference; rnai; silencing; sirna; specific; targeting; virus; viruses; vitro cache: cord-349358-leicos9j.txt plain text: cord-349358-leicos9j.txt item: #530 of 549 id: cord-349790-dezauioa author: Johnson, Stephanie title: Ethical challenges in pathogen sequencing: a systematic scoping review date: 2020-06-03 words: 6223 flesch: 38 summary: In general, public health laws are quite strong in shielding public health data, but that may not be the case with research data. If there is uncertainty about whether such data are protected, any participants in research should be notified. keywords: data; health; literature; pathogen; public; research; risk; sequencing; studies; study; use cache: cord-349790-dezauioa.txt plain text: cord-349790-dezauioa.txt item: #531 of 549 id: cord-350221-8u6q3wfa author: Yang, Sung-Tae title: HIV virions sense plasma membrane heterogeneity for cell entry date: 2017-06-28 words: 7819 flesch: 49 summary: This result agrees with a previous report demonstrating a decrease of HIV cell entry after depletion of cholesterol from the host cell membrane (22) . Cell membranes consist of numerous proteins and lipids exhibiting complex behavior that includes organization into dynamic nanodomains enriched in sphingolipids and cholesterol that are sometimes referred to as lipid rafts (1, 2) . keywords: binding; boundaries; ccr5; cd4; cells; domains; env; fig; fusion; gpmvs; hiv; lipid; membrane; particles; phase cache: cord-350221-8u6q3wfa.txt plain text: cord-350221-8u6q3wfa.txt item: #532 of 549 id: cord-350443-ca5avyjf author: Zhang, Lei title: Trends in Notifiable Infectious Diseases in China: Implications for Surveillance and Population Health Policy date: 2012-02-16 words: 7966 flesch: 45 summary: In 1955, a total of 5,970,000 malaria cases were reported nationally, accounting for 68% of the total number of reported infectious disease cases and an incidence of 1,028 per 100,000 population. Vaccine-preventable diseases, bacterial infections and gastrointestinal diseases were the greatest causes of death, accounting for 30.0%, 24.0% and 19.5% of reported infectious diseases death cases among Chinese population in 1975 ( Figure 1b) . keywords: cases; china; chinese; diseases; epidemic; health; hiv; mortality; number; population; rate; surveillance; transmission cache: cord-350443-ca5avyjf.txt plain text: cord-350443-ca5avyjf.txt item: #533 of 549 id: cord-350540-s6is9ndm author: Pinto, Rogério M. title: COVID-19 Pandemic Disrupts HIV Continuum of Care and Prevention: Implications for Research and Practice Concerning Community-Based Organizations and Frontline Providers date: 2020-04-28 words: 2029 flesch: 38 summary: The New York Times Perspectives of Linkage to Care Among People Diagnosed With HIV HIV testing, care referral and linkage to care intervals affect time to engagement in care for newly diagnosed HIV-infected adolescents in fifteen adolescent medicine clinics in the United States Challenges and Successes in Linking HIV-Infected Women to Care in the United States Barriers and facilitators of linkage to HIV primary care in New York City Barriers to HIV Care and Treatment Among Participants in a Public Health HIV Care Relinkage Program Why Physicians Don't Ask: Interpersonal and Intrapersonal Barriers to HIV Testing-Making a Case for a Patient-Initiated Campaign A client-centered relational framework on barriers to the integration of HIV and substance use services: a systematic review Factors that influence linkages to HIV Continuum of Care Services: Implications for multi-Level interventions Unpredictable Work Timing in Retail Jobs: Implications for Employee Work-Life Conflict Limited effectiveness of antiviral treatment for hepatitis C in an urban HIV clinic The Values and Value of Patient-Centered Care Beyond patient-centred care: A conceptual framework of co-production mechanisms with vulnerable groups in health and social service settings Crossing the Quality Chasm: A New Health System for the 21st Century What 'patient-centered' should mean: Confessions of an extremist Retention in HIV care among participants in the patient-centered hiv care model: a collaboration between community-based pharmacists and primary medical providers Is the quality of the patient-provider relationship associated with better adherence and health outcomes for patients with HIV? Co-production in the treatment of substance use disorder and its relationship to clinic's service output patterns Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Furthermore, evidence suggests that frontline providers who more frequently link clients to HIV services tend to do so as part of face-to-face client meetings, at which the provider might ask the client, while still in their presence, to contact the referral, or the provider might make the contact and hand the client written information [12] . keywords: care; clients; health; hiv; providers; services cache: cord-350540-s6is9ndm.txt plain text: cord-350540-s6is9ndm.txt item: #534 of 549 id: cord-350569-dtxtjtfo author: Kasoka, Kasoka title: Autonomy in HIV testing: a call for a rethink of personal autonomy in the HIV response in sub-Saharan Africa date: 2020-06-13 words: 13925 flesch: 45 summary: For example, the current COVID-19 lockdown and social distancing rules indicate that human autonomy is not absolute. I agree with Crittenden's theory of social autonomy, even though there are issues which arise from a further reading of his account which I do not necessarily agree with. keywords: accounts; autonomy; consent; desires; ethics; hiv; hiv testing; human; individual; killmister; order; people; person; self; society; ssa; testing; values cache: cord-350569-dtxtjtfo.txt plain text: cord-350569-dtxtjtfo.txt item: #535 of 549 id: cord-350571-6tapkjb6 author: None title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 words: 106086 flesch: 45 summary: Clinical pharmacists have a role to evaluate and optimize the appropriateness and effectiveness of patient's medications. DTSIs interventions (treatment group) consist in: motivational interview, sharing and delivery of printed, explanatory material in the patient's native language, reconciliation of patients medications at hospital admission and at discharge; identification of potential risks due to drug-drug interactions; monitoring of compliance to drug therapy, and finally detection of adverse drug reactions (ADRs) occurring in the course of care. keywords: abstract; adherence; administration; admission; age; aim; analysis; antibiotics; assessment; associated; average; background; cancer; care; cases; clinical; community; conclusion; control; criteria; data; day; days; department; design; discharge; discrepancies; disease; dispensing; dosage; dose; drug; effects; following; general; group; guidelines; health; home; hospital; hospital pharmacy; impact; increase; information; interactions; interventions; knowledge; level; main; management; mean; measures; median; medical; medication; medication adherence; medication reconciliation; medicines; method; monitoring; months; n =; non; number; nurses; objective; oral; order; outcome; outcome measures; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; potential; practice; prescribed; prescription; problems; process; projects; quality; research; results; review; risk; risk patients; role; safety; score; service; setting; study; survey; team; therapy; time; total; treatment; type; university; use; years cache: cord-350571-6tapkjb6.txt plain text: cord-350571-6tapkjb6.txt item: #536 of 549 id: cord-351004-h6fde7vm author: Gudipati, Smitha title: Descriptive Analysis of Patients Living With HIV Affected by COVID-19 date: 2020-07-13 words: 2474 flesch: 50 summary: Our case series, the current published literature on HIV and SARS-CoV-2, and the published data from HFH on COVID-19 patients without known HIV supports the theory that there is not an excess morbidity and mortality among PLWH affected by COVID-19 compared with the general public. 4 In the United States, Detroit, Michigan, had become a hotspot of COVID-19 infected patients with the number of confirmed cases reaching 47,182 as of May 8, 2020, with 4555 deaths in Michigan (fourth most deaths in the United States). keywords: covid-19; hiv; infection; patients; plwh; sars cache: cord-351004-h6fde7vm.txt plain text: cord-351004-h6fde7vm.txt item: #537 of 549 id: cord-351740-779g8tr1 author: Khaba, Moshawa Calvin title: COVID-19 in an HIV-infected patient. Lessons learned from an autopsy case date: 2020-09-25 words: 1830 flesch: 51 summary: J o u r n a l P r e -p r o o f Articles Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy : a two-centre descriptive study Clinical Characteristics and Outcomes in People Living With Human Immunodeficiency Virus Hospitalized for Coronavirus Disease Articles Pulmonary and cardiac pathology in African American patients with COVID-19 : an autopsy series from New Orleans Articles Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State : a case series Hematologic parameters in patients with COVID-19 infection Clinical features and outcomes of HIV patients with coronavirus disease 2019 COVID -19 in people living with human immunodeficiency virus : a case series of 33 patients Outcomes Among HIV-Positive Patients Hospitalized With COVID-19 The final cause of death was SARS-CoV-2 (COVID-19) infection in HIV infected patient. keywords: cov-2; covid-19; hiv; infection; patients; sars cache: cord-351740-779g8tr1.txt plain text: cord-351740-779g8tr1.txt item: #538 of 549 id: cord-353012-rxhi8wd2 author: Zhou, Nan title: Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) date: 2016-03-07 words: 6443 flesch: 42 summary: Mechanistic studies showed that teicoplanin blocks Ebola virus entry by specifically inhibiting the activity of cathepsin L, opening a novel avenue for the development of additional glycopeptides as potential inhibitors of cathepsin L-dependent viruses. The compound virus pre-incubation assay demonstrated that when teicoplanin was pre-incubated with Ebola/ HIV pseudotyped viruses and then filtered and washed away, the inhibitory effect of the antibiotic on Ebola virus entry did not occur (Fig. 3A) . keywords: activity; cathepsin; cells; cov; ebola; entry; fig; hiv; sars; teicoplanin; viruses cache: cord-353012-rxhi8wd2.txt plain text: cord-353012-rxhi8wd2.txt item: #539 of 549 id: cord-353895-tgn1kk07 author: Kavanagh, Matthew M title: Reckoning with mortality: global health, HIV, and the politics of data date: 2020-07-03 words: 1849 flesch: 41 summary: PEPFAR took the bold step, in 2019, of requiring the programmes it funds to report on HIV mortality. Global Burden of Disease Compare Beyond precision: embracing the politics of global health numbers Generation of political priority for global health initiatives: a framework and case study of maternal mortality Metric partnerships: global burden of disease estimates within the World Bank, the World Health Organisation, and the Institute for Health Metrics and Evaluation Counting the dead and what they died from: an assessment of the global status of cause of death data Reliable direct measurement of causes of death in low-and middle-income countries A global assessment of civil registration and vital statistics systems: monitoring data quality and progress Improved retention rates with low-cost interventions in hypertension and diabetes management in a rural African environment of nurse-led care: a cluster-randomised trial Loss-to-follow-up on multidrug resistant tuberculosis treatment in Gujarat, India: the when and who of it Estimation of mortality among HIV-infected people on antiretroviral treatment in East Africa: a sampling based approach in an observational, multisite, cohort study Retention and mortality on antiretroviral therapy in sub-Saharan Africa: collaborative analyses of HIV treatment programmes High proportions of patients with advanced HIV are antiretroviral therapy experienced: hospitalization outcomes from 2 sub-Saharan African sites HIV-related medical admissions to a South African district hospital remain frequent despite effective antiretroviral therapy scale-up Care continuum and postdischarge outcomes among HIV-infected adults admitted to the hospital in Zambia Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy. keywords: data; health; hiv; mortality; programmes cache: cord-353895-tgn1kk07.txt plain text: cord-353895-tgn1kk07.txt item: #540 of 549 id: cord-354029-mp5r82g4 author: Earp, L. J. title: The Many Mechanisms of Viral Membrane Fusion Proteins date: 2005 words: 12136 flesch: 38 summary: Activation and inactivation of the membrane fusion capacity of the hemagglutinin pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane Role of metastability and acidic pH in membrane fusion by tick-borne encephalitis virus Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus Membrane interactions of the tick-borne encephalitis virus fusion protein E at low pH Detection of an interaction between the HN and F proteins in Newcastle disease virus-infected cells Membrane interface-interacting sequences within the ectodomain of the human immunodeficiency virus type 1 envelope glycoprotein: putative role during viral fusion Lipid rafts and assembly of enveloped viruses Soluble receptor potentiates receptor-independent infection by murine coronavirus Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion Viral fusion peptides: a tool set to disrupt and connect biological membranes Structure and function of membrane fusion peptides The role of the membrane-spanning domain sequence in glycoprotein-mediated membrane fusion Oligomerization, secretion, and biological function of an anchor-free parainfluenza virus type 2 (PI2) fusion protein Regulation of fusion activity by the cytoplasmic domain of a paramyxovirus F protein A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells Sphingolipid and cholesterol dependence of alphavirus membrane fusion. A envelope glycoprotein Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity Viral entry and receptors Entry of Semliki forest virus into cells: effects of concanamycin A and nigericin on viral membrane fusion and infection Mutational analysis of the putative fusion domain of Ebola virus glycoprotein Membrane fusion Functional analysis of the cytoplasmic tail of Moloney murine leukemia virus envelope protein Covalent modifications of the ebola virus glycoprotein Peptide and non-peptide HIV fusion inhibitors A core trimer of the paramyxovirus fusion protein: parallels to influenza virus hemagglutinin and HIV-1 gp41 Membrane structure of the human immunodeficiency virus gp41 fusion domain by molecular dynamics simulation Structural features of membrane fusion between influenza virus and liposome as revealed by quick-freezing electron microscopy Intermonomer disulfide bonds impair the fusion activity of influenza virus hemagglutinin Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion Membrane fusion and the alphavirus life cycle Mechanisms of mutations inhibiting fusion and infection by Semliki Forest virus Specific roles for lipids in virus fusion and exit. keywords: cell; domain; envelope; et al; fig; fusion; fusion peptide; fusion proteins; glycoprotein; helix; hiv; influenza; membrane; membrane fusion; peptide; protein; structure; target; terminal; transmembrane; virus cache: cord-354029-mp5r82g4.txt plain text: cord-354029-mp5r82g4.txt item: #541 of 549 id: cord-354050-kcn67stj author: Shi, Guoli title: More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins date: 2017-11-21 words: 6879 flesch: 31 summary: It was reported that elevated levels of IFITM3 protein in memory CD8+ T lymphocytes, which kill virus-infected cells and serve as important targets themselves for IAV infection in the lung, promotes their survival during infection and enables long-term defense against future viral exposures [65] . A recent and comprehensive study now links an additional variant in the IFITM3 locus to severe influenzaassociated illness in three independent cohorts, albeit the SNP identified is distinct from rs12252-C. Known as rs34481144-A, it is found in the 5' untranslated region and is linked to lower IFITM3 protein levels in cells keywords: activity; cell; entry; env; fusion; ifitm; infection; interferon; membrane; proteins; restriction; transmembrane; virion; virus; viruses cache: cord-354050-kcn67stj.txt plain text: cord-354050-kcn67stj.txt item: #542 of 549 id: cord-354374-rtgjjglc author: C.G. Pollok, Richard title: Enteric viruses in HIV-related diarrhoea date: 2000-12-01 words: 3491 flesch: 32 summary: CMV infection of the GI tract, in patients with AIDS have diminished greatly. The pathogenic role of CMV infection is well established. keywords: adenovirus; cmv; cytomegalovirus; diarrhoea; disease; hiv; infection; patients cache: cord-354374-rtgjjglc.txt plain text: cord-354374-rtgjjglc.txt item: #543 of 549 id: cord-354790-xx6imhzb author: Lambour, Jennifer title: Converting monoclonal antibody-based immunotherapies from passive to active: bringing immune complexes into play date: 2016-08-17 words: 6514 flesch: 25 summary: Tsouchnikas et al. 84 investigated the influence of immunization with ICs on the specificity of antibody responses using the E protein of the tick-borne encephalitis virus as an immunogen. Thus, such phenomena can profoundly influence the fine specificity of antibody responses to the same immunogen and must be considered in IC-based vaccination strategies. keywords: antibodies; antibody; antiviral; cell; hiv; ics; immune; infection; mabs; responses; virus cache: cord-354790-xx6imhzb.txt plain text: cord-354790-xx6imhzb.txt item: #544 of 549 id: cord-354972-nc496v6s author: Margolin, Emmanuel title: Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa date: 2020-09-10 words: 10934 flesch: 27 summary: The host immune response in respiratory virus infection: balancing virus clearance and immunopathology Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection Disappearance of antibodies to SARS-associated coronavirus after recovery Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome Positive RT-PCR test results in patients recovered from COVID-19 Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Immunization with inactivated Middle East respiratory syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge Molecular mechanism for antibodydependent enhancement of coronavirus entry Medical countermeasures analysis of 2019-nCoV and vaccine risks for antibody-dependent enhancement (ADE) Several strategies may improve the magnitude and durability of vaccine responses in individuals infected with HIV-1, such as higher doses, booster immunizations and/or the use of adjuvants 127 . keywords: africa; cases; coronavirus; countries; cov-2; covid-19; development; disease; individuals; infection; pandemic; patients; responses; risk; sars; south; spike; testing; trial; tuberculosis; vaccine; virus cache: cord-354972-nc496v6s.txt plain text: cord-354972-nc496v6s.txt item: #545 of 549 id: cord-354974-bh2expef author: Peterson, Ingrid title: Respiratory Virus–Associated Severe Acute Respiratory Illness and Viral Clustering in Malawian Children in a Setting With a High Prevalence of HIV Infection, Malaria, and Malnutrition date: 2016-09-13 words: 3868 flesch: 40 summary: A total of 605 SARI cases (26.8%) had warning signs, which were positively associated with HIV infection (adjusted risk ratio [aRR], 2.4; 95% confidence interval [11] , we conducted active surveillance at a large urban teaching hospital in Malawi to estimate the incidence of childhood SARI and explore the association of SARI clinical severity with HIV infection and clustering of respiratory viral coinfection. keywords: cases; children; hiv; influenza; sari; signs; viral; virus; warning; years cache: cord-354974-bh2expef.txt plain text: cord-354974-bh2expef.txt item: #546 of 549 id: cord-355318-qm79gz8w author: Smit, Albertus J. title: Winter Is Coming: A Southern Hemisphere Perspective of the Environmental Drivers of SARS-CoV-2 and the Potential Seasonality of COVID-19 date: 2020-08-05 words: 15421 flesch: 37 summary: A systematic review and meta-analysis Effect of routine isoniazid preventive therapy on tuberculosis incidence among HIV-Infected men in South Africa Tuberculosis in sub-Saharan Africa: Opportunities, challenges, and change in the era of antiretroviral treatment Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: A modelling study COVID-19 in HIV Investigators COVID-19 in patients with HIV: Clinical case series Maintaining HIV care during the COVID-19 pandemic Impact of COVID-19 on tuberculosis control in China COVID-19: Getting ahead of the epidemic curve by early implementation of social distancing Viral dynamics in mild and severe cases of COVID-19 Report from the American Society for Microbiology COVID-19 International Summit Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals COVID-19: A need for real-time monitoring of weekly excess deaths No association of COVID-19 transmission with temperature or UV radiation in Chinese cities Impact of weather on COVID-19 pandemic in Turkey Association between ambient temperature and COVID-19 infection in 122 cities from China Modeling infectious disease dynamics in the complex landscape of global health Rt COVID-19 Renormalization group approach to pandemics: The COVID-19 case. Revista Ibero-Americana de Ciências Ambientias 2020 Gaussian approach for probability and correlation between the number of COVID-19 cases and the air pollution in Lima The role of climate during the COVID-19 epidemic in New South Wales Correlation between climate indicators and COVID-19 pandemic Correlation between weather and Covid-19 pandemic in Jakarta Effect of weather on COVID-19 spread in the US: A prediction model for India in 2020 Impact of meteorological factors on the COVID-19 transmission: A multi-city study in China The role of environmental factors on transmission rates of the COVID-19 Outbreak: An initial assessment in two spatial scales The ERA-interim reanalysis: Configuration and performance of the data assimilation system The sensitivity and specificity analyses of ambient temperature and population size on the transmission rate of the novel coronavirus (COVID-19) in different provinces in Iran Non-linear modulation of COVID-19 transmission by climate conditions Transmissibility of COVID-19 and its association with temperature and humidity Developing a machine learning framework to determine the spread of COVID-19. keywords: air; cases; countries; cov-2; covid-19; data; disease; hemisphere; humidity; infection; influenza; models; pandemic; rate; sars; seasonality; spread; studies; temperature; time; transmission; variables; virus cache: cord-355318-qm79gz8w.txt plain text: cord-355318-qm79gz8w.txt item: #547 of 549 id: cord-355439-eqtk51q3 author: Lesko, Catherine R title: HIV and SARS-CoV-2: Intersecting Epidemics with Many Unknowns date: 2020-07-22 words: 3292 flesch: 28 summary: The Nielsen Company (US) Reducing HIV risks in the places where people drink: prevention interventions in alcohol venues The Mental Health Consequences of COVID-19 and Physical Distancing: The Need for Prevention and Early Intervention Mental Health, Psychosocial Challenges and Resilience in Older Adults Living with HIV An Examination of the Social Networks and Social Isolation in Older and Younger Adults Living with HIV/AIDS Society of Behavioral Medicine Calls for Equitable Healthcare during COVID-19 Pandemic Patients with mental health disorders in the COVID-19 epidemic The burden of COVID-19 in people living with HIV: a syndemic perspective Economic, Mental Health, HIV Prevention and HIV Treatment Impacts of COVID-19 and the COVID-19 response on a Global Sample of Cisgender Gay Men and Other Men who have sex with Men Epidemiology of COVID-19 among people experiencing homelessness: early evidence from Boston COVID-19 Outbreak Among Three Affiliated Homeless Service Sites COVID-19 in Prisons and Jails in the United States Flattening the Curve for Incarcerated Populations -Covid-19 in Jails and Prisons Understanding Socioeconomic Disparities in Travel Behavior during the COVID-19 Pandemic From HIV to Coronavirus: AIDS Service Organizations Adaptative Responses to COVID-19 When less is better Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city, China COVID-19 in patients with HIV: clinical case series SARS-CoV-2 and HIV HIV/SARS-CoV-2 coinfected patients in Istanbul, Turkey A Case of HIV and SARS-CoV-2 Co-infection in Singapore HIV and SARS-CoV-2 co-infection: A case report from Uganda Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus Clinical features and outcomes of HIV patients with coronavirus disease 2019 COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients Prevalence, clinical characteristics and treatment outcomes of HIV and SARS-CoV-2 co-infection: a systematic review and meta-analysis A survey for COVID-19 among HIV/AIDS patients in two Districts of Wuhan, China Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort Outcomes Among People Living with HIV During the COVID-19 Pandemic People with HIV at greater risk of COVID-19 death in South African study Johns Hopkins Bloomberg School of Public Health Center for Health Security Blood tests show 2.2 percent of RIers have coronavirus antibodies keywords: cov-2; covid-19; health; hiv; people; plwh; risk; sars cache: cord-355439-eqtk51q3.txt plain text: cord-355439-eqtk51q3.txt item: #548 of 549 id: cord-355475-kdubhh73 author: Patton, Lauren L. title: Viral Pandemics and Oral Health: Lessons Learned From HIV to SARS-CoV-2 date: 2020-11-05 words: 2162 flesch: 36 summary: Oral Surg Oral Med Oral Pathol Oral Radiol DOI: 10.1016/j.oooo.2020.10.022 sha: doc_id: 355475 cord_uid: kdubhh73 nan training was from James J. Crawford, PhD and I was memorably impacted by his What if Saliva Were Red video. The real hope is for saliva-based point-of-care rapid tests, as was created in OraQuick Advance® HIV-1/2 (Orasure Technologies, Inc.) for diagnosis of HIV infection. keywords: covid-19; disease; health; hiv; infection; patients; saliva; sars cache: cord-355475-kdubhh73.txt plain text: cord-355475-kdubhh73.txt item: #549 of 549 id: cord-355541-5sctqkwr author: Alcamí, José title: Current situation in the development of a preventive HIV vaccine date: 2005-07-31 words: 7265 flesch: 32 summary: Finally, social, economic and healthcare aspects of research into HIV vaccines and current controversies regarding the development of clinical trials are discussed. HIV vaccine trial justified A canarypox vaccine expressing multiple human immunodeficiency virus type 1 genes given alone or with rgp120 elicits broad and durable CD8+ cytotoxic T lymphocyte responses in seronegative volunteers Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA primemodified vaccinia virus ankara boost vaccination regimen Why an HIV vaccine is not currently within our grasp. keywords: aids; antibodies; cells; development; escape; hiv; infection; patients; phase; proteins; replication; response; trials; vaccine; virus cache: cord-355541-5sctqkwr.txt plain text: cord-355541-5sctqkwr.txt