id	author	title	date	pages	extension	mime	words	sentence	flesch	summary	cache	txt
cord-002407-25cawzi0	Nogales, Aitor	Reverse Genetics Approaches for the Development of Influenza Vaccines	2016-12-22		.txt	text/plain	11138	463	36	A virus hemagglutinin viral RNA are important for efficient packaging into budding virions Experimental approaches to study genome packaging of influenza A viruses Plasmid-only rescue of influenza A virus vaccine candidates Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza Attenuated influenza virus vaccines with modified NS1 proteins Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine Attenuation of equine influenza viruses through truncations of the NS1 protein Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs Characterization of influenza virus variants with different sizes of the non-structural (NS) genes and their potential as a live influenza vaccine in poultry Development of a dual-protective live-attenuated vaccine against H5N1 and H9N2 avian influenza viruses by modifying the NS1 gene Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus NS1-truncated live-attenuated virus vaccine provides robust protection to aged mice from viral challenge Influenza B virus NS1-truncated mutants: Live-attenuated vaccine approach Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach Development of live-attenuated arenavirus vaccines based on codon deoptimization Live attenuated influenza virus vaccines by computer-aided rational design Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice A replication-incompetent virus possessing an uncleavable hemagglutinin as an influenza vaccine Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity Characterization of a neuraminidase-deficient influenza A virus as a potential gene delivery vector and a live vaccine A novel bivalent vaccine based on a PB2-knockout influenza virus protects mice from pandemic H1N1 and highly pathogenic H5N1 virus challenges A replication-incompetent PB2-knockout influenza A virus vaccine vector Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus An eight-segment swine influenza virus harboring H1 and H3 hemagglutinins is attenuated and protective against H1N1 and H3N2 subtypes in pigs A recombinant influenza virus vaccine expressing the f protein of respiratory syncytial virus To date, three types of influenza virus vaccines are approved by the Food and Drug Administration (FDA) for human use: recombinant viral HA, inactivated virus and live-attenuated viruses [65] [66]	cache/cord-002407-25cawzi0.txt	txt/cord-002407-25cawzi0.txt
