        item: #1 of 58
          id: cord-000354-05lnj3w0
      author: de Vries, Erik
       title: Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway
        date: 2011-03-31
       words: 10993
      flesch: 42
     summary: Clathrin mediated endocytosis (CME) has for long been identified and studied as the major route of IAV cell entry [1, 2] and is, by far, the best characterized endocytic pathway. Reversible inhibitors like dynasore [60] offer a major advantage for characterization of IAV entry pathways.
    keywords: actin; cells; dyna; dynamin; dynasore; entry; fcs; fig; iav; iav entry; ind; infection; inhibitors; macropinocytosis; pathway; pbs; presence; serum; virus
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        item: #2 of 58
          id: cord-000434-ff2zadol
      author: Zhao, Rongmao
       title: Identification of a Highly Conserved H1 Subtype-Specific Epitope with Diagnostic Potential in the Hemagglutinin Protein of Influenza A Virus
        date: 2011-08-19
       words: 5789
      flesch: 46
     summary: The structure and function of the hemagglutinin membrane glycoprotein of influenza virus Influenza vaccines for the future Characterization of a novel influenza hemagglutinin, H15: criteria for determination of influenza A subtypes Manual of Diagnostic Tests and Vaccines for Terrestrial Animals Development of blocking ELISA for detection of antibodies against avian influenza virus of the H7 subtype Development of epitope-blocking ELISA for universal detection of antibodies to human H5N1 influenza viruses A laboratory manual for the isolation and identification of avian pathogens Comparison of the hemagglutination-inhibiting and neutralizing antibody responses of volunteers given 400 chick cellagglutinating units of influenza A/New Jersey/76 split-virus vaccine Role of the laboratory in diagnosis of influenza during seasonal epidemics and potential pandemics Development of rHA1-ELISA for specific and sensitive detection of H9 subtype influenza virus Prokaryotic expression and purification of HA1 and HA2 polypeptides for serological analysis of the 2009 pandemic H1N1 influenza virus Utility of pandemic H1N1 2009 influenza virus recombinant hemagglutinin protein-based enzymelinked immunosorbent assay for serosurveillance Ab and T cell epitopes of influenza A virus, knowledge and opportunities Epitope analysis for influenza vaccine design Quantifying influenza vaccine efficacy and antigenic distance Antigenic characterization of recombinant hemagglutinin proteins derived from different avian influenza virus subtypes Epitope mapping of the hemagglutinin molecule of a highly pathogenic H5N1 influenza virus by using monoclonal antibodies Evaluation of the subtype specificity of monoclonal antibodies raised against H1 and H3 subtypes of human influenza A virus hemagglutinins Establishment of retroviral pseudotypes with influenza hemagglutinins from H1, H3, and H5 subtypes for sensitive and specific detection of neutralizing antibodies Minimum requirements for immunogenic and antigenic activities of homologs of a synthetic peptide of influenza virus hemagglutinin Genetic control and fine specificity of the immune response to a synthetic peptide of influenza virus hemagglutinin Microneutralizing test is an alternative method to type and subtype influenza viruses.
    keywords: antibodies; antibody; elisa; epitopes; fig; iav; influenza; p31; peptides; subtype; virus
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        item: #3 of 58
          id: cord-002407-25cawzi0
      author: Nogales, Aitor
       title: Reverse Genetics Approaches for the Development of Influenza Vaccines
        date: 2016-12-22
       words: 11138
      flesch: 36
     summary: A virus hemagglutinin viral RNA are important for efficient packaging into budding virions Experimental approaches to study genome packaging of influenza A viruses Plasmid-only rescue of influenza A virus vaccine candidates Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza Attenuated influenza virus vaccines with modified NS1 proteins Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine Attenuation of equine influenza viruses through truncations of the NS1 protein Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs Characterization of influenza virus variants with different sizes of the non-structural (NS) genes and their potential as a live influenza vaccine in poultry Development of a dual-protective live-attenuated vaccine against H5N1 and H9N2 avian influenza viruses by modifying the NS1 gene Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus NS1-truncated live-attenuated virus vaccine provides robust protection to aged mice from viral challenge Influenza B virus NS1-truncated mutants: Live-attenuated vaccine approach Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach Development of live-attenuated arenavirus vaccines based on codon deoptimization Live attenuated influenza virus vaccines by computer-aided rational design Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice A replication-incompetent virus possessing an uncleavable hemagglutinin as an influenza vaccine Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity Characterization of a neuraminidase-deficient influenza A virus as a potential gene delivery vector and a live vaccine A novel bivalent vaccine based on a PB2-knockout influenza virus protects mice from pandemic H1N1 and highly pathogenic H5N1 virus challenges A replication-incompetent PB2-knockout influenza A virus vaccine vector Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus An eight-segment swine influenza virus harboring H1 and H3 hemagglutinins is attenuated and protective against H1N1 and H3N2 subtypes in pigs A recombinant influenza virus vaccine expressing the f protein of respiratory syncytial virus To date, three types of influenza virus vaccines are approved by the Food and Drug Administration (FDA) for human use: recombinant viral HA, inactivated virus and live-attenuated viruses [65] [66]
    keywords: cells; eggs; figure; genetics; genome; iav; ibv; influenza; influenza virus; live; production; proteins; replication; strains; vaccine; virus; viruses
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        item: #4 of 58
          id: cord-002823-n55xvwkf
      author: Halstead, E. Scott
       title: GM-CSF overexpression after influenza a virus infection prevents mortality and moderates M1-like airway monocyte/macrophage polarization
        date: 2018-01-05
       words: 8101
      flesch: 38
     summary: BAL airway macrophages were sorted using the gating strategy described in Fig. 4a and next generation RNA-sequencing was used to profile the complete transcriptome data of AMs (a, orange bars) and EMs (b, blue bars) at 8 dpi, the time point at which the survival curves diverge (n = 5 mice per group). BAL airway macrophages were sorted and RNA-sequencing was performed to compare the gene expression between IAV-infected LM (n = 5 mice) and DTGM (n = 5 mice) treated with doxycycline at 8 dpi.
    keywords: airway; ams; bal; cell; csf; data; dtgm; expression; fig; iav; infection; influenza; levels; lung; macrophages; mice; rna
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        item: #5 of 58
          id: cord-003169-bdw5ke4i
      author: Guo, Hongbo
       title: Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces
        date: 2018-08-13
       words: 11639
      flesch: 42
     summary: The ratio (initial virus binding rate v obs in absence of OC)/(initial virus binding rate v obs in presence of 10 μM OC) of four viruses carrying the WSN WT NA in the background four different HAs was plotted (the individual binding curves are shown in S9 Fig) . We conclude that, in addition to HA binding properties, NA activity drastically affects virus binding dynamics in the absence of NA inhibitors.
    keywords: activity; binding; fetuin; fig; iav; influenza; mtsin; particles; pr8; rate; receptor; sia; specificity; surface; virus; viruses; wsn
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        item: #6 of 58
          id: cord-003498-4ct0ywnw
      author: Bdeir, Najat
       title: A system for production of defective interfering particles in the absence of infectious influenza A virus
        date: 2019-03-01
       words: 6225
      flesch: 42
     summary: Thus, more red fluorescent cells were observed when supernatants from PB2 expressing cells were added to MDCK-PB2opt as compared to MDCK-PB2 cells (Fig 5B) . This matches data published for DI-244 generated by use of standard virus [35] and demonstrates that DIPs produced in PB2 expressing cells are fully functional, although the activity of purified DIPs remains to be examined.
    keywords: cells; di-244; dips; fig; iav; influenza; mdck; pb2; pb2opt; production; supernatants; virus
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        item: #7 of 58
          id: cord-003598-m2fsrwvw
      author: Elbahesh, Husni
       title: Response Modifiers: Tweaking the Immune Response Against Influenza A Virus
        date: 2019-04-12
       words: 4176
      flesch: 22
     summary: Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice PAR1 contributes to influenza A virus pathogenicity in mice Increased survival after gemfibrozil treatment of severe mouse influenza TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice Treating influenza infection, from now and into the future Angiopoietinlike 4 interacts with matrix proteins to modulate wound healing Role of Angptl4 in vascular permeability and inflammation H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression Relevance of signaling molecules for apoptosis induction on influenza A virus replication Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice Innate immune responses to influenza A H5N1: friend or foe? Repurposing host-based therapeutics to control coronavirus and influenza virus Repurposing of drugs as novel influenza inhibitors from clinical gene expression infection signatures Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction Network-guided discovery of influenza virus replication host factors Cellular networks involved in the influenza virus life cycle Genetic screens for the control of influenza virus replication: from meta-analysis to drug discovery Meta-and orthogonal integration of influenza OMICs data defines a role for UBR4 in virus budding The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL Pathogenic potential of interferon alphabeta in acute influenza infection Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins
    keywords: cells; host; iav; immune; infections; influenza; mice; protein; replication; responses; virus
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        item: #8 of 58
          id: cord-003639-bjtxf1y8
      author: Vahey, Michael D
       title: Influenza A virus surface proteins are organized to help penetrate host mucus
        date: 2019-05-14
       words: 9673
      flesch: 33
     summary: To quantify alignment between the HA-NA axis of a virus particle and the direction of its displacement from the associated ECL track ( Figure 4E ), fluorescent images of HA, NA, and ECL were segmented in both HA (to identify virus particles) and ECL (to identify regions of cleaved sialic acid) channels. Polarized viruses step persistently away from their NA-rich pole To directly test how NA polarization might affect virus motion, we characterized interactions between fluorescently-labeled viruses and sialic acid coated coverslips, where the well-defined geometry and density of sialic acid allow straightforward analysis of virus diffusion (Materials and methods) (Figure 2A ).
    keywords: acid; binding; diffusion; figure; influenza; organization; particles; surface; virus; viruses
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        item: #9 of 58
          id: cord-003772-1345qct4
      author: Kummer, Susann
       title: IFITM3 Clusters on Virus Containing Endosomes and Lysosomes Early in the Influenza A Infection of Human Airway Epithelial Cells
        date: 2019-06-12
       words: 7861
      flesch: 39
     summary: Some co-localization of NP with IFITM3 and Rab11 signals was observed on apparently vesicular structures in the extranuclear space of IAV infected A549 cells at 1-6 h p.i. Some co-localization of NP with IFITM3 and Rab11 signals was observed on apparently vesicular structures in the extranuclear space of IAV infected A549 cells at 1-6 h p.i.
    keywords: a549; a549 cells; cells; clustering; endosomal; endosomes; figure; iav; ifitm3; infection; influenza; localization; signal; virus
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        item: #10 of 58
          id: cord-003870-hr99dwi7
      author: Clohisey, Sara
       title: Host susceptibility to severe influenza A virus infection
        date: 2019-09-05
       words: 6002
      flesch: 38
     summary: IFITM3 has also been recently shown to have a protective effect on the heart during severe IAV infection. A more recent study of Han Chinese individuals that looked at several genes confirmed an association between CD55 rs2564978 T/T and death from severe IAV infection [72] .
    keywords: associated; cell; disease; gene; host; iav; infection; influenza; pandemic; risk; study; susceptibility; virus
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        item: #11 of 58
          id: cord-003888-lgutt1r9
      author: Lauterbach, Sarah E.
       title: Assessing exhibition swine as potential disseminators of infectious disease through the detection of five respiratory pathogens at agricultural exhibitions
        date: 2019-09-18
       words: 2550
      flesch: 33
     summary: Measures to minimize influenza transmission at swine exhibitions Subclinical influenza virus A infections in pigs exhibited at agricultural fairs Characterization of an influenza A virus isolated from pigs during an outbreak of respiratory disease in swine and people during a county fair in the United States Simultaneous infection of pigs and people with triple-reassortant swine influenza virus H1N1 at a U.S. county fair Active surveillance for influenza A virus among swine, midwestern United States The pig as a mixing vessel for influenza viruses: human and veterinary implications Evolutionary Dynamics of influenza A viruses in US exhibition swine Outbreak of Influenza A(H3N2) variant virus infections among persons attending agricultural fairs housing infected swine-Michigan and Ohio Outbreak of influenza A (H3N2) variant virus infection among attendees of an agricultural fair Movement patterns of exhibition swine and associations of influenza A virus infection with swine management practices Potential role of noncommercial swine populations in the epidemiology and control of porcine reproductive and respiratory syndrome virus Introduction, evolution, and dissemination of influenza A viruses in exhibition swine in the United States during 2009 to 2013 Porcine hemagglutinating encephalomyelitis virus and respiratory disease in exhibition swine Complete genome sequence of an influenza D virus strain identified in a pig with subclinical infection in the United States Widespread detection and characterization of porcine parainfluenza virus 1 in pigs in the USA Nasal wipes for influenza A virus detection and isolation from swine Utility of snout wipe samples for influenza A virus surveillance in exhibition swine populations Prevalence of influenza A virus in exhibition swine during arrival at agricultural fairs Isolation of a novel swine influenza virus from Oklahoma in 2011 which is distantly related to human influenza C viruses Two cases of flu linked to contact with swine at Fowlerville fair. key: cord-003888-lgutt1r9 authors: Lauterbach, Sarah E.; Nelson, Sarah W.; Robinson, Meghann E.; Lorbach, Josh N.; Nolting, Jacqueline M.; Bowman, Andrew S. title: Assessing exhibition swine as potential disseminators of infectious disease through the detection of five respiratory pathogens at agricultural exhibitions date: 2019-09-18 journal: Vet Res DOI: 10.1186/s13567-019-0684-5 sha: doc_id: 3888 cord_uid: lgutt1r9 Widespread geographic movement and extensive comingling of exhibition swine facilitates the spread and transmission of infectious pathogens.
    keywords: exhibitions; influenza; pathogens; pigs; swine; virus
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        item: #12 of 58
          id: cord-004018-33zi29bg
      author: Coombs, Kevin M.
       title: Aptamer Profiling of A549 Cells Infected with Low-Pathogenicity and High-Pathogenicity Influenza Viruses
        date: 2019-11-05
       words: 5408
      flesch: 39
     summary: [13] . Genome-wide RNAi screens and mRNA microarray screens identified >1500 cellular genes and proteins influenza virus may depend upon [28] human lung cell proteins affected by the different IAV strains, and identified more than 500 significantly dysregulated cellular proteins.
    keywords: cells; h5n1; h7n9; infection; influenza; pr8; proteins; strains; virus; viruses
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        item: #13 of 58
          id: cord-004280-c470nlie
      author: Coleman, Kristen K.
       title: Airborne Influenza A Virus Exposure in an Elementary School
        date: 2020-02-05
       words: 4124
      flesch: 33
     summary: Our study represents the first identification and quantification of airborne influenza virus in an elementary school, and the results suggest that airborne IAV has the potential to circulate in schools during influenza season, in large enough doses known to cause infection. Although airborne influenza virus has been detected in select indoor settings 37, 38, 44, [61]
    keywords: air; densities; iav; influenza; particles; rna; school; student; transmission; virus
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        item: #14 of 58
          id: cord-006362-7d5wzb7p
      author: van Riel, Debby
       title: Influenza pathogenicity during pregnancy in women and animal models
        date: 2016-07-07
       words: 5042
      flesch: 34
     summary: A virus subtype H1N1 The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation Association between severe pandemic 2009 influenza A (H1N1) virus infection and immunoglobulin G(2) subclass deficiency Imbalanced anti-H1N1 immunoglobulin subclasses and dysregulated cytokines in hospitalized pregnant women with 2009 H1N1 influenza and pneumonia in Shenyang, China pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature Perinatal outcomes after maternal 2009/ H1N1 infection: national cohort study Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China Influenza and congenital anomalies: a systematic review and meta-analysis Transplacental passage of influenza A/ Bangkok (H3N2) mimicking amniotic fluid infection syndrome High rate of chronic villitis in placentas of pregnancies complicated by influenza A/H1N1 infection Fatal influenzal pneumonia in pregnancy: failure to demonstrate transplacental transmission of influenza virus Influenza, hyperthermia, and congenital malformation Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice The 2009 pandemic H1N1 influenza virus is more pathogenic in pregnant mice than seasonal H1N1 influenza virus Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice Highly pathogenic avian influenza H5N1 virus could partly be evacuated by pregnant BALB/c mouse during abortion or preterm delivery Association of foetal wastage with influenza infection during ferret pregnancy The pregnant guinea-pig as a model for studying influenza virus infection in utero: infection of foetal tissues in organ culture and in vivo Pathology of human influenza revisited The influence of experimental infection of gilts with swine H1N2 influenza A virus during the second month of gestation on the course of pregnancy, reproduction parameters and clinical status Pregnancy outcome and clinical status of gilts following experimental infection by H1N2, H3N2 and H1N1pdm09 influenza [37, 38] which largely determine the cell tropism of influenza viruses within the respiratory tract.
    keywords: cells; h1n1; iav; infection; influenza; mice; pandemic; pregnancy; virus; women
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        item: #15 of 58
          id: cord-007853-5xnft6pd
      author: Lai, Yanni
       title: 3D-quantitative structure–activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase
        date: 2020-04-04
       words: 5856
      flesch: 43
     summary: Bioavailability of curcumin: problems and promises Oseltamivir inhibits influenza virus replication and transmission following ocular-only aerosol inoculation of ferrets Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice Inhibition of enveloped viruses infectivity by curcumin Oseltamivir-resistant influenza viruses isolated in South Korea from Inhibition of curcumin on influenza A virus infection and influenzal pneumonia via oxidative stress, TLR2/4, p38/JNK MAPK and NF-κB pathways Integration of target discovery, drug discovery and drug delivery: a review on computational strategies A universal human influenza A vaccine A new protocol for predicting novel GSK-3beta ATP competitive inhibitors Beware of q2! Curcumin as Curecumin: from kitchen to clinic 3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase The anesthetic action of some polyhalogenated ethers-Monte Carlo method based QSAR study Zanamivirresistant influenza viruses with a novel neuraminidase mutation Antiviral potential of natural compounds against influenza virus hemagglutinin Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance Multiple biological activities of curcumin: a short review Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaBinhibiting activity Global transmission of oseltamivir-resistant influenza Structural domains and organizational conformation involved in the sorting and transport of influenza virus transmembrane proteins New method for rapid characterization of molecular shapes: applications in drug design Roles of neuraminidase in the initial stage of influenza virus infection Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity 3D QSAR and molecular docking studies of benzimidazole derivatives as hepatitis C virus NS5B polymerase inhibitors Toward a universal influenza virus vaccine: prospects and challenges Synergic effect of curcumin and its structural analogue (monoacetylcurcumin) on anti-influenza virus infection Emergence of amantadine-resistant influenza A viruses: epidemiological study The first pandemic of the 21st century: a review of the 2009 pandemic variant influenza A (H1N1) virus Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic The pathology of influenza virus infections 3D-QSAR analysis of a series of S-DABO derivatives as anti-HIV agents by CoMFA and CoM-SIA Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors Acknowledgements This study was supported by the National Natural Science Foundation of China (No 81470186). The X-ray structure of influenza virus neuraminidase (code: 4HZZ) was taken from the RSCB Protein Data Bank (Fang et al. 2011 ).
    keywords: activity; cells; curcumin; derivatives; iav; infection; influenza; mice; model; neuraminidase; virus
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        item: #16 of 58
          id: cord-011438-imbpgsub
      author: Zhang, Yun
       title: Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
        date: 2020-03-29
       words: 9339
      flesch: 34
     summary: hemagglutinin genes Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes A virus nucleoprotein induces apoptosis in human airway epithelial cells: Implications of a novel interaction between nucleoprotein and host protein Clusterin Autophagy induction regulates influenza virus replication in a time-dependent manner Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins Host Immune Response to Influenza A Virus Infection NKp46 O-Glycan Sequences That Are Involved in the Interaction with Hemagglutinin Type 1 of Influenza Virus Evasion of natural killer cells by influenza virus Respiratory Influenza Virus Infection Induces Memory-like Liver NK Cells in Mice Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice NK cells exacerbate the pathology of influenza virus infection in mice Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection A Role for Neutrophils in Viral Respiratory Disease.
    keywords: activation; apoptosis; avian; cells; host; human; iav; iavs; ifn; immunity; infection; influenza; pathway; protein; receptor; replication; responses; rna; type; virus; viruses
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        item: #17 of 58
          id: cord-013174-whg64w0w
      author: Bhatta, Tarka Raj
       title: Infection Dynamics of Swine Influenza Virus in a Danish Pig Herd Reveals Recurrent Infections with Different Variants of the H1N2 Swine Influenza A Virus Subtype
        date: 2020-09-10
       words: 8222
      flesch: 53
     summary: A virus discovered from pigs in Germany Molecular epidemiology and evolution of influenza viruses circulating within European swine between Reassortant pandemic (H1N1) 2009 virus in pigs Triple-reassortant influenza A virus with H3 of human seasonal origin, NA of swine origin, and internal A (H1N1) pandemic 2009 genes is established in Danish pigs Genetic and biological characterisation of an avian-like H1N2 swine influenza virus generated by reassortment of circulating avian-like H1N1 and H3N2 subtypes in Denmark Why are RNA virus mutation rates so damn high? Evasion of influenza A viruses from innate and adaptive immune responses Substantial Antigenic Drift in the Hemagglutinin Protein of Swine Influenza A Viruses Molecular basis of the structure and function of H1 hemagglutinin of influenza virus Structural basis of influenza virus neutralization Vaccination potential of B and T epitope-enriched NP and M2 against influenza A viruses from different clades and hosts Cross-reactive human B cell and T cell epitopes between influenza A and B viruses Conserved epitopes of influenza A virus inducing protective immunity and their prospects for universal vaccine development Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population Glycosylation of hemagglutinin and neuraminidase of influenza a virus as signature for ecological spillover and adaptation among influenza reservoirs Structural Development in Danish Pig Production StatPearls Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: A clinical and virological study Interaction between Mycoplasma hyopneumoniae and swine influenza virus Swine influenza viruses: A North American perspective Development of a high-throughput real-time PCR system for detection of enzootic pathogens in pigs Raised without antibiotics Monitoring of Influenza A Virus in Pig Final Development and evaluation of a one-step real-time RT-PCR assay for universal detection of influenza A viruses from avian and mammal species Limited impact of influenza A virus vaccination of piglets in an enzootic infected sow herd Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses MUSCLE: A viruses The biology of influenza viruses
    keywords: acid; amino; antigenic; gene; iav; influenza; level; pigs; sequences; sites; swiav; swine; virus; week
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        item: #18 of 58
          id: cord-028887-eseo7lyh
      author: Li, Chong
       title: Exploring heterologous prime-boost vaccination approaches to enhance influenza control in pigs
        date: 2020-07-09
       words: 7583
      flesch: 48
     summary: The genomic evolution of H1 influenza A viruses from swine detected in the United States between Host immune response to influenza a virus infection Development of TH1 CD4 + T cells through IL-12 produced by Listeriainduced macrophages Swine 2012 part II: Reference of swine health and health management in the United States Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine Live attenuated influenza virus vaccine reduces virus shedding of newborn piglets in the presence of maternal antibody A paradigm shift in vaccine production for pandemic influenza The influenza vaccine licensing process Review of influenza A virus in swine worldwide: a call for increased surveillance and research Heterologous Prime-Boost immunisation in Ebola vaccine development, testing and licensure Heterologous prime-boost vaccination Short-and long-term protective efficacy against clade 2.3. When seeder pigs were confirmed IAV positive in their nasal secretions by RRT-PCR, two seeder pigs (one H1 seeder and one H3 seeder) were commingled with the pigs in each room.
    keywords: aut; boost; challenge; com; groups; heterologous; iav; influenza; laiv; pigs; prime; treatment; vaccination; vaccine; virus
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        item: #19 of 58
          id: cord-102458-7sssm3zk
      author: Milanez-Almeida, Pedro
       title: Blood gene expression-based prediction of lethality after respiratory infection by influenza A virus in mice
        date: 2020-10-27
       words: 4637
      flesch: 29
     summary: Briefly, to be considered for inclusion in the signature of lethality, on days 1 to 3 after infection genes had to be differentially expressed (DE) , in comparison to PBS-treated animals, in the lungs of lethally infected mice but not DE in the lungs of non-lethally infected animals (see Fig. 1 and Methods for more details) (13, 22, 23) . By day four, however, DE of all 9 positive control of infection genes could be detected in the blood of animals infected with 1 LD50 PR8 (Fig. S5c) , likely reflecting the spread of PR8 in the lungs and evolving host immunity.
    keywords: blood; data; genes; iav; infection; influenza; lethal; lethality; mice; model
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        item: #20 of 58
          id: cord-102471-dtukacm7
      author: Xu, Y.
       title: Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission
        date: 2020-04-22
       words: 4456
      flesch: 44
     summary: Further optimization is needed to improve the sensitivity of our protocol for clinical samples with lower viral titres (Ct values >30). How to be ready for the next influenza pandemic Real-time, portable genome sequencing for Ebola surveillance Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples Rapid metagenomic identification of viral pathogens in clinical samples by real-time nanopore sequencing analysis Diagnostic tests for influenza infection.
    keywords: author; funder; influenza; license; medrxiv; perpetuity; preprint; samples; sequencing
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        item: #21 of 58
          id: cord-102586-mx534xbx
      author: Javaid, W.
       title: Real Time Investigation of a large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology
        date: 2020-05-15
       words: 3202
      flesch: 43
     summary: Nosocomial influenza virus outbreaks have been described worldwide (1-3); 66 children, the elderly, institutionalized and immuno-compromised patients are particularly vulnerable. key: cord-102586-mx534xbx authors: Javaid, W.; Ehni, J.; Gonzalez-Reiche, A. S.; Carreno, J. M.; Hirsch, E.; Tan, J.; Khan, Z.; Kriti, D.; Ly, T.; Kranitzky, B.; Barnett, B.; Cera, F.; Prespa, L.; Moss, M.; Albrecht, R. A.; Mustafa, A.; Herbison, I.; Hernandez, M. M.; Pak, T.; Alshammary, H.; Sebra, R.; Smith, M.; Krammer, F.; Gitman, M.; Sordillo, E. M.; Simon, V.; van Bakel, H. title: Real Time Investigation of a large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology date: 2020-05-15 journal: nan DOI: 10.1101/2020.05.10.20096693 sha: doc_id: 102586 cord_uid: mx534xbx Background: Nosocomial respiratory virus outbreaks represent serious public health challenges.
    keywords: hcws; iav; influenza; license; outbreak; preprint; virus
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        item: #22 of 58
          id: cord-255980-u0c6pg8n
      author: Du, Lanying
       title: Development of a safe and convenient neutralization assay for rapid screening of influenza HA-specific neutralizing monoclonal antibodies
        date: 2010-07-02
       words: 3689
      flesch: 39
     summary: A virus hemagglutinin provides immunity in mice to influenza A virus challenge DNA vaccine encoding hemagglutinin provides protective immunity against H5N1 influenza virus infection in mice Safety and immunogenicity of a baculovirus-expressed hemagglutinin influenza vaccine: a randomized controlled trial Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab-phage display library Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets Neutralizing anti-influenza virus monoclonal antibodies: therapeutics and tools for discovery Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza Combination therapy using chimeric monoclonal antibodies protects mice from lethal H5N1 infection and prevents formation of escape mutants Human single-chain antibodies that neutralize homologous and heterologous strains and clades of influenza A virus subtype H5N1 Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses Development of a safe neutralization assay for SARS-CoV and characterization of S-glycoprotein Generation and characterization of an H5N1 avian influenza virus hemagglutinin glycoprotein pseudotyped lentivirus Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses Analysis of hemagglutininmediated entry tropism of H5N1 avian influenza Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies Recombinant receptor-binding domain of SARS-CoV spike protein expressed in mammalian, insect and E. coli cells elicits potent neutralizing antibody and protective immunity Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies Emergence and pandemic potential of swine-origin H1N1 influenza virus Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunity Heterosubtype neutralizing responses to influenza A (H5N1) viruses are mediated by antibodies to virus haemagglutinin Generation, characterization and epitope mapping of two neutralizing and protective human recombinant antibodies against influenza A H5N1 viruses Supernatants containing HA pseudovirus with or without NA were harvested 72 h post-transfection, and used for single-cycle infection.
    keywords: assay; cells; h1n1; h5n1; influenza; mabs; pseudovirus
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        item: #23 of 58
          id: cord-260452-js4nr4d8
      author: Yu, Junyang
       title: Activation and Role of NACHT, LRR, and PYD Domains-Containing Protein 3 Inflammasome in RNA Viral Infection
        date: 2017-10-31
       words: 4114
      flesch: 16
     summary: Viral RNA (vRNA) moleculeinduced NLRP3 inflammasome activation also comes about by post-translational priming, but involving the RIP1/caspase 8/RIP3 signaling pathway (29, 45) , which may ultimately result in the deubiquitination of NLRP3 protein by BRCC3 (46, 47) . Among the other viral proteins involved in NLRP3 inflammasome activation are IAV PB1-F2 (a small protein encoded by an alternate + 1 open reading frame in the viral PB1 gene) (7) and EV71 3D protein (an RNA-dependent RNA polymerase) (34) .
    keywords: activation; cells; iav; infection; inflammasome; nlrp3; protein; response; rna; virus
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        item: #24 of 58
          id: cord-267531-tqqj4cy0
      author: He, Ying
       title: A 3-year prospective study of the epidemiology of acute respiratory viral infections in hospitalized children in Shenzhen, China
        date: 2014-05-14
       words: 4691
      flesch: 50
     summary: Overall, 48Á0% of our cases were positive for respiratory virus infections, which resembled the latest study in the same city. Limited data are available in China to describe the epidemiology of viral respiratory infections, especially in small–medium cities and rural areas.
    keywords: children; iav; infection; rate; studies; study; viruses
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        item: #25 of 58
          id: cord-272117-erzpz3c0
      author: Downey, Jeffrey
       title: Dissecting host cell death programs in the pathogenesis of influenza
        date: 2018-04-18
       words: 9262
      flesch: 28
     summary: Moreover, the magnitude of epithelial cell apoptosis was positively associated with IAV strain pathogenicity in vivo [32, 23, 48] and in vitro Support for the protective capacity of apoptosis is that critical host antiviral factors actively induce epithelial cell apoptosis.
    keywords: apoptosis; cells; death; host; human; iav; ifn; infection; influenza; lung; macrophages; pulmonary; replication; virus
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        item: #26 of 58
          id: cord-275821-yu39aw54
      author: Ciminski, Kevin
       title: Novel insights into bat influenza A viruses
        date: 2017-09-14
       words: 5229
      flesch: 40
     summary: A virus genomic RNA segments A supramolecular assembly formed by influenza A virus genomic RNA segments An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus A functional sequence-specific interaction between influenza A virus genomic RNA segments An infectious bat-derived chimeric influenza virus harbouring the entry machinery of an influenza A virus Characterization of uncultivable bat influenza virus using a replicative synthetic virus Pathogenicity of modified bat influenza virus with different M genes and its reassortment potential with swine influenza Likewise, based on experiments with chimeric bat influenza viruses, genomic reassortment is believed to occur in cells co-infected with the known bat IAV subtypes.
    keywords: bat; cell; genome; iav; iavs; influenza; packaging; proteins; subtypes; virus; viruses
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        item: #27 of 58
          id: cord-278465-tjjkz16y
      author: Wille, Michelle
       title: Urbanization and the dynamics of RNA viruses in Mallards (Anas platyrhynchos)
        date: 2017-03-18
       words: 5894
      flesch: 41
     summary: All viruses were identified as gammacoronaviruses, and fell into the clade dominated by wild bird viruses and those recovered from domestic ducks. In context of IAV, and to a lesser degree CoV and APMV-1, an assessment of virus prevalence and diversity in an urban population will further allow us to assess if dynamics in wild birds are reflected in an urban setting.
    keywords: avian; birds; cov; ducks; et al; fig; iav; influenza; mallards; prevalence; rna; viruses; wild
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        item: #28 of 58
          id: cord-278523-djjtgbh6
      author: Zhou, Bei-xian
       title: β-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling
        date: 2020-06-05
       words: 11767
      flesch: 45
     summary: We confirmed the anti-apoptotic effect of βsitosterol by measuring the active caspase-3 and its substrate PARP, observing that these products were found in cells transfected with vRNA but not in those treated with β-sitosterol Fig. 4 (continued) β-Sitosterol ameliorates IAV-induced inflammation and ALI BX Zhou (Fig. 5b) . Moreover, β-sitosterol treatment attenuated RIG-I-mediated apoptotic injury of alveolar epithelial cells (AEC) via downregulation of pro-apoptotic factors.
    keywords: activation; cells; effect; expression; fig; group; iav; ifn; infection; influenza; lung; mice; rig; signaling; sitosterol; treatment; virus
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        item: #29 of 58
          id: cord-286741-h3oix9zc
      author: Park, Mee Sook
       title: Animal models for the risk assessment of viral pandemic potential
        date: 2020-04-22
       words: 9626
      flesch: 42
     summary: A viruses Rescue of influenza A virus from recombinant DNA A DNA transfection system for generation of influenza A virus from eight plasmids African green monkey kidney (Vero) cells provide an alternative host cell system for influenza A and B viruses High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state Receptor binding specificity of recent human H3N2 influenza viruses Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses Pathogenesis of influenza virus infections: the good, the bad and the ugly Molecular pathology of emerging coronavirus infections Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses Replication and pathogenic potential of influenza A virus subtypes H3, H7, and H15 from free-range ducks in Bangladesh in mammals Virulence determinants of pandemic A(H1N1)2009 influenza virus in a mouse model Sialic acid recognition is a key determinant of influenza A virus tropism in murine trachea epithelial cell cultures Effective replication of human influenza viruses in mice lacking a major alpha2,6 sialyltransferase The C-type lectin Langerin functions as a receptor for attachment and infectious entry of influenza A virus Nlinked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN Evolving complexities of influenza virus and its receptors Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads to loss of neuraminidase activity Adaptation of pandemic H1N1 influenza viruses in mice Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus Three mutations switch H7N9 influenza to human-type receptor specificity Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission Influenza H1N1 A/Solomon Island/ 3/06 virus receptor binding specificity correlates with virus pathogenicity, antigenicity, and immunogenicity in ferrets Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic Effects of HA and NA glycosylation pattern changes on the transmission of avian influenza A(H7N9) virus in Guinea pigs The contribution of animal models to the understanding of the host range and virulence of influenza A viruses Animal models for influenza virus transmission studies: a historical perspective Animal models for influenza virus pathogenesis and transmission Bronchointerstitial pneumonia in Guinea pigs following inoculation with H5N1 high pathogenicity avian influenza virus Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a Guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding The Guinea pig as a transmission model for human influenza viruses Syrian hamster as an animal model for the study of human influenza virus infection Animal models in influenza vaccine testing A virus obtained from influenza patients Transmission of influenza B viruses in the Guinea pig Transmission in the Guinea pig model The use of nonhuman primates in research on seasonal, pandemic and avian influenza Pathogenesis of influenza A (H5N1) virus infection in a primate model Experimental production of respiratory tract disease in cebus monkeys after intratracheal or intranasal infection with influenza A/Victoria/3/75 or influenza A/New Jersey/76 virus African green monkeys recapitulate the clinical experience with replication of live attenuated pandemic influenza virus vaccine candidates Evaluation of replication, immunogenicity and protective efficacy of a live attenuated cold-adapted pandemic H1N1 influenza virus vaccine in non-human primates Establishment of a cynomolgus macaque model of influenza B virus infection A single amino acid in the polymerase acidic protein determines the pathogenicity of influenza B viruses Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice DBA/2 mouse as an animal model for anti-influenza drug efficacy evaluation The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model Development of animal models against emerging coronaviruses: from SARS to MERS coronavirus The ferret as a model organism to study influenza A virus infection Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Livestock susceptibility to infection with Middle East respiratory syndrome coronavirus Host determinants of MERS-CoV transmission and pathogenesis Pneumonia from human coronavirus in a macaque model An acute immune response to Middle East respiratory syndrome coronavirus replication contributes to viral pathogenicity Permissivity of dipeptidyl peptidase 4 Orthologs to Middle East respiratory syndrome coronavirus is governed by glycosylation and other complex determinants Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Pre-and postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection A mouse model for MERS coronavirus-induced acute respiratory distress syndrome A human DPP4-Knockin Mouse's susceptibility to infection by authentic and Pseudotyped MERS-CoV Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Lack of Middle East respiratory syndrome coronavirus transmission in rabbits Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Pathogenicity and viral shedding of MERS-CoV in immunocompromised rhesus macaques Infection with MERS-CoV causes lethal pneumonia in the common marmoset Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2 Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein Species-specific Colocalization of Middle East
    keywords: animal; avian; cov; human; iavs; infection; influenza; mers; mice; pandemic; receptor; swine; tract; transmission; virus; viruses
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        item: #30 of 58
          id: cord-288705-f3zqhpx1
      author: Slaine, Patrick
       title: Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model
        date: 2020-10-01
       words: 6063
      flesch: 32
     summary: To test this directly, we performed HCoV-285 with the strong effect on infectious virion production, we also observed significant, dose-294 dependent reductions in viral protein accumulation due to 6-TG and 6-TGo treatment in HCoV-295 OC43-infected HCT-8 cells (Fig. 6C , the main band recognized by the anti-OC43 antibody is 296 consistent with the size of the nucleocapsid N protein). 396 Our data also highlight the sensitivity of membrane anchored viral proteins to 6-TG treatment.
    keywords: accumulation; cells; fig; iav; infected; protein; replication; tgo; treatment; upr
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        item: #31 of 58
          id: cord-291014-cfnoxhtd
      author: Zheng, Jian
       title: Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host
        date: 2018-02-28
       words: 4404
      flesch: 21
     summary: Nevertheless, the role of epigenetic modification during respiratory virus infection is not well understood; the application of phosphoproteomics to characterization of the human macrophage response to IAV infection [113] serves as a model for future studies. [63] Nuclear import and export machinery IAV IAV have evolved different mechanisms to utilize importin-alpha isoforms, affecting importation on both sides of the nuclear envelope.
    keywords: cells; cov; host; iav; infection; influenza; memory; mers; protein; responses; role; sars; virus; viruses
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        item: #32 of 58
          id: cord-291534-c6cjxq07
      author: Gwyer Findlay, Emily
       title: Cationic Host Defence Peptides: Potential as Antiviral Therapeutics
        date: 2013-05-07
       words: 8792
      flesch: 33
     summary: A/PR/8/34 hemagglutinin (H1 subtype) alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s) Role of protein kinase C betaII in influenza virus entry via late endosomes Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D Mechanism of adenovirus neutralization by human alpha-defensins Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy Human alpha-defensins block papillomavirus infection Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro Adenovirus-directed ocular innate immunity: the role of conjunctival defensin-like chemokines (IP-10, I-TAC) and phagocytic human defensin-alpha Critical determinants of human alpha-defensin 5 activity against nonenveloped viruses Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection Enhanced expression of murine beta-defensins (MBD-1, -2,-3, and -4) in upper and lower airway mucosa of influenza virus infected mice Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivo Role of human beta-defensin-2 during tumor necrosis factor-alpha/NF-kappaB-mediated innate antiviral response against human respiratory syncytial virus Oral human beta-defensin 2 in HIV-infected subjects with long-term use of antiretroviral therapy Human betadefensins suppress human immunodeficiency virus infection: potential role in mucosal protection Cutting edge: human beta defensin 3-a novel antagonist of the HIV-1 coreceptor CXCR4 beta-Defensin genomic copy number is associated with HIV load and immune reconstitution in subsaharan Africans Increased levels of human betadefensins mRNA in sexually HIV-1 exposed but uninfected individuals Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity Recombinant mouse beta-defensin 2 inhibits infection by influenza A virus by blocking its entry Antiviral activity of recombinant mouse beta-defensin 3 against influenza A virus in vitro and in vivo Cytokine (tumor necrosis factor, IL-6, and IL-8) production by respiratory syncytial virus-infected human alveolar macrophages Antiviral activity of human beta-defensin 3 against vaccinia virus Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins Retrocyclin: a primate peptide that protects cells from infection by T-and M-tropic strains of HIV-1 Evaluation of a theta-defensin in a murine model of herpes simplex virus type 1 keratitis. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cellinduced T cell polarization Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium Direct inactivation of viruses by human granulocyte defensins Human alpha-and beta-defensins block multiple steps in herpes simplex virus infection Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry Multivalent binding of carbohydrates by the human alpha-defensin, HD5 Defensins inhibit HIV replication in vitro Contribution of human alpha-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor Retraction of an interpretation Alpha-defensins in the prevention of HIV transmission among breastfed infants Multifaceted mechanisms of HIV-1 entry inhibition by human alpha-defensin Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity Alphadefensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4 Alpha-defensins inhibit HIV infection of macrophages through upregulation of CC-chemokines Contribution of immune activation to the pathogenesis and transmission of human immunodeficiency virus type 1 infection Defensins induce the recruitment of dendritic cells in cervical human papillomavirus-associated (pre)neoplastic lesions formed in vitro and transplanted in vivo Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment Antibacterial peptides in bronchoalveolar lavage fluid Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis Production of beta-defensins by human airway epithelia Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins The antigenic structure of the influenza virus
    keywords: activity; alpha; beta; cells; defensins; effects; expression; hiv; hnp1; host; human; infection; ll-37; peptide; potential; properties; virus
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        item: #33 of 58
          id: cord-296890-08kqtw8s
      author: Toh, Teck-Hock
       title: High Prevalence of Viral Infections Among Hospitalized Pneumonia Patients in Equatorial Sarawak, Malaysia
        date: 2019-02-13
       words: 4332
      flesch: 46
     summary: T One pediatric patient specimen destroyed, assay results out of n = 599. Surveillance for emerging respiratory viruses Global epidemiology of non-influenza RNA respiratory viruses: data gaps and a growing need for surveillance Addressing the public health burden of respiratory viruses: the Battle against Respiratory Viruses (BRaVe) initiative Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis Global burden of childhood pneumonia and diarrhoea Clinical and economic burden of community-acquired pneumonia amongst adults in the Asia-Pacific region The bacterial aetiology of adult community-acquired pneumonia in Asia: a systematic review Assessing the burden of pneumonia using administrative data from Malaysia, Indonesia, and the Philippines Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: a retrospective study of 27 years Surveillance for respiratory syncytial virus and parainfluenza virus among patients hospitalized with pneumonia in Sarawak Community-acquired pneumonia requiring hospitalization among U.S. children Community-acquired pneumonia requiring hospitalization among U.S. adults Humidity as a non-pharmaceutical intervention for influenza A Absolute humidity modulates influenza survival, transmission, and seasonality Respiratory syncytial virus-a comprehensive review Pneumonia: a global cause without champions Respiratory syncytial virus subtype A was detected in the third patient's NP swab.
    keywords: age; hospital; patients; pneumonia; prevalence; rsv; sibu; specimens; study; years
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        item: #34 of 58
          id: cord-298458-p7rvupjo
      author: Schmidt, Megan E.
       title: The CD8 T Cell Response to Respiratory Virus Infections
        date: 2018-04-09
       words: 8972
      flesch: 27
     summary: Although mice depleted of CD8 T cells exhibited elevated lung viral titers, weight loss and symptom illness scores were significantly reduced in CD8 T cell depleted mice following acute RSV infection (26) . Similar reduction in disease severity was also demonstrated following either HMPV or PVM infection of CD8 T cell depleted mice or mice genetically deficient in CD8 T cells, respectively (40, 103).
    keywords: cd8; cd8 t; cells; iav; infection; lung; memory; mice; rsv; t cells; virus
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        item: #35 of 58
          id: cord-300423-q2i328sz
      author: Bai, Lei
       title: Co-infection of influenza A virus enhances SARS-CoV-2 infectivity
        date: 2020-10-14
       words: 1475
      flesch: 57
     summary: To study the interaction between IAV and SARS-CoV-2, A549 (a hypotriploid alveolar A549 was converted to be highly sensitive (up to 10,000-fold) against the pSARS-CoV-2 72 virus after different doses of IAV infections (from low MOI of 0.01 to high MOI of 1, also 73 shown by pSARS-CoV-2 with mCherry reporter in Fig. Mice were infected with 3x10 5 PFU of SARS-CoV-2 with or without 90 2000 PFU of IAV pre-infection and were then sacrificed two days later after SARS-CoV-2 91 infection (the experimental scheme is shown in Fig. 2A) .
    keywords: cov-2; iav; infection; sars
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        item: #36 of 58
          id: cord-307148-k1uo3fxm
      author: Bradshaw, Patrick C.
       title: COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm
        date: 2020-09-09
       words: 20848
      flesch: 35
     summary: Therefore, R-BHB may mitigate respiratory virus infection both by increasing LL-37 levels and by increasing NADPH levels [16] that protect LL-37 from inactivation. Increased NADPH levels also have been shown to stimulate antiviral immunity by decreasing the level of the NADPH sensor protein HSCARG, which is a negative regulator of NF-κB transcription.
    keywords: acid; activity; bhb; cells; covid-19; cytokine; decrease; diet; effects; expression; fat; function; gene; glucose; iav; increase; infection; inflammatory; inhibition; ketogenic; ketone; levels; lung; macrophages; metabolism; mice; mitochondrial; nadph; production; response; ros; sars; signaling; storm
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        item: #37 of 58
          id: cord-307813-elom30nx
      author: Yip, Tsz-Fung
       title: Advancements in Host-Based Interventions for Influenza Treatment
        date: 2018-07-10
       words: 15110
      flesch: 27
     summary: Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency Disease-promoting effects of type I interferons in viral, bacterial, and coinfections Protection from lethal influenza virus challenge by oral type 1 interferon Low-dose oral interferon alpha as prophylaxis against viral respiratory illness: a double-blind, parallel controlled trial during an influenza pandemic year IFNlambda is a potent anti-influenza therapeutic without the inflammatory side effects of IFNalpha treatment Pathogenic potential of interferon alphabeta in acute influenza infection The superiority of IFN-lambda as a therapeutic candidate to control acute influenza viral lung infection Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of gammadelta T cells Interferon-lambda mediates non-redundant front-line antiviral protection against influenza virus infection without compromising host fitness RIG-I activation protects and rescues from lethal influenza virus infection and bacterial superinfection Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages Modified Jiu Wei Qiang Huo decoction improves dysfunctional metabolomics in influenza A pneumoniainfected mice Pattern recognition receptors and inflammation Cutting edge: There is an urgent need to search for alternative targets to treat influenza virus infections, including non-viral targets such as host cellular factors; which are promising as viruses rely on the host machinery for replication.
    keywords: addition; antiviral; cells; complex; drug; export; host; human; iav; immune; infected; infection; influenza; inhibitor; lung; membrane; mice; nuclear; production; protein; replication; role; treatment; type; viral; virus; viruses; vitro; vrnp
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        item: #38 of 58
          id: cord-309010-tmfm5u5h
      author: Dietert, Kristina
       title: Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia
        date: 2017-11-20
       words: 7851
      flesch: 26
     summary: https://doi.org/10.1371/journal.pone.0188251.g010 Comparative histopathology of mouse models of acute pneumonia semiquantification of mouse pneumonia is inconceivable. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies.
    keywords: + +; acute; alveolar; cov; fig; iav; infection; lesions; lung; mers; mice; model; mouse; pathogen; pneumonia
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        item: #39 of 58
          id: cord-309381-cb80ntxs
      author: Nogales, Aitor
       title: Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans
        date: 2019-09-30
       words: 10240
      flesch: 40
     summary: Just as an example mentioned below, IFITM3 is an ISG playing antiviral roles against influenza virus infection and other viruses [59] . B influenza viruses: Basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 northern hemisphere season Prevention and Control of Seasonal Influenza with Vaccines The annual impact of seasonal influenza in the US: Measuring disease burden and costs The continual threat of influenza virus infections at the human-animal interface: What is new from a one health perspective?
    keywords: allele; cells; disease; expression; gene; host; human; iav; ifitm3; infection; influenza; nucleotide; polymorphisms; protein; receptor; responses; risk; snps; susceptibility; type; virus; viruses
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        item: #40 of 58
          id: cord-310004-h9ixhhzz
      author: Yuan, Shuofeng
       title: Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target
        date: 2020-08-28
       words: 9566
      flesch: 43
     summary: ACA targets host AP2M1 protein ACA is known as a phospholipase A2 (PLA2) inhibitor and transient receptor potential (TRP) channel blocker (15) , but such mechanisms for suppressing viral replication were excluded ( fig. (D) Histopathologic and immunohistochemistry (IHC) analyses of the brain samples at 6 dpi indicated less severe meningitis (by H&E, ×200) and less virus infected cells as indicated by ZIKV NS1 antigen staining (red arrows, by IHC, ×200 magnification) after ACA treatment.
    keywords: a71; aca; antiviral; ap2m1; binding; cells; cov; fig; group; host; human; iav; infection; influenza; mice; protein; replication; spectrum; trafficking; virus; viruses; yxxø; zikv
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        item: #41 of 58
          id: cord-310780-0k8owwf8
      author: Iwai, Atsushi
       title: Relevance of signaling molecules for apoptosis induction on influenza A virus replication
        date: 2013-11-22
       words: 3669
      flesch: 28
     summary: IAV M1 protein is involved in cell susceptibility to apoptosis through binding to an anti-apoptotic protein, Hsp70, and M2 protein is indirectly involved in apoptosis induction through inhibition of type II programmed cell death, macroautophagy. Death receptors, such as TNFaR1 (tumor necrosis factor a receptor 1), Fas, DR4 (death receptor 4, also called TRAILR1) and Abbreviations: Akt, v-akt murine thymoma viral oncogene homolog 1; Apaf-1, apoptotic protease activating factor 1; Bax, Bcl-2-associated x protein; Bcl-2, B-cell lymphoma 2; BH, Bcl-2 homology; Caspases, cysteine-aspartic acid protease; DAP3, death-associated protein 3; DR4, death receptor 4; DR5, death receptor 5; FADD, Fas-associated death domain; IAV, influenza A virus; IFN, interferon; IPS-1, INF-b promoter stimulator protein 1; IRF3, IFN regulatory factor 3; JNK, c-Jun aminoterminal kinase; M, matrix protein; NF-jB, nuclear factor-jB; NA, neuraminidase; NP, nucleoprotein; NS1, non-structural protein 1; PI3K, phosphatidylinositol-3 kinase; RIG-I, retinoic acid-inducible gene-I; TNF-a, tumor necrosis factor a; TNFaR1, TNF-a receptor 1; TRADD, tumor necrosis factor receptor type 1-associated death domain protein; TRAIL, TNF-related apoptosis inducing ligand; XIAP, X-linked inhibitor of apoptosis protein; ZAPS, zinc finger antiviral protein, short form.
    keywords: activation; apoptosis; death; iav; induction; protein; virus
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        item: #42 of 58
          id: cord-314825-fzba05wn
      author: Chauhan, Ravendra P.
       title: A Systematic Review Analyzing the Prevalence and Circulation of Influenza Viruses in Swine Population Worldwide
        date: 2020-05-08
       words: 22381
      flesch: 51
     summary: H9N2 seroprevalence among pig population and pig farm staff in Shandong Serological evidence of hepatitis E virus and influenza A virus infection in farmed wild boars in China Identification of a potential novel type of influenza virus in Bovine in China Emergence of avian H1N1 influenza viruses in pigs in China Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity First report of seroprevalence of swine influenza A virus in Tibetan pigs in Tibet Seroprevalence and associated risk factors of important pig viral diseases in Bhutan Serologic evidence of human influenza virus infections in swine populations Influenza A Virus in Backyard Pigs and Poultry in Rural Cambodia An outbreak of influenza in the swine with Hong Kong influenza virus (author's transl) Antigenic and genetic analysis of A/Hong Kong (H3N2) influenza viruses isolated from swine and man The follow-up study of swine and Hong Kong influenza virus infection among Japanese hogs Isolation of a recombinant influenza virus (Hsw 1 N2) from swine in Japan Sero-epizootiological study on swine influenza in a prefecture of Japan Further isolation of a recombinant virus (H1N2, formerly Hsw1N2) from a pig in Japan in 1980 The possible origin H1N1 (Hsw1N1) virus in the swine population of Japan and antigenic analysis of the isolates Prevalence of antibody to influenza C virus among pigs in Hyogo Prefecture Distribution of the antibody to influenza C virus in dogs and pigs in Yamagata Prefecture Continued circulation of reassortant H1N2 influenza viruses in pigs in Japan Novel reassortant influenza A(H1N2) virus derived from A(H1N1)pdm09 virus isolated from swine Occurrence of a pig respiratory disease associated with swine influenza A (H1N2) virus in Tochigi Prefecture Prevalence of antibodies to type A influenza viruses in swine sera 1990-1994 Antigenic and genetic characteristics of H1N1 human influenza virus isolated from pigs in Japan Genomic reassortants of pandemic A (H1N1) 2009 virus and endemic porcine H1 and H3 viruses in swine in Japan Influenza A virus infection Serological survey of influenza A virus infection in Japanese wild boars (Sus scrofa leucomystax) Isolation of H3N2 swine influenza virus in South Korea Genetic characterization of H7N2 influenza virus isolated from pigs Detection and isolation of H1N1 influenza virus from pigs in Korea Localization of swine influenza virus in naturally infected pigs First outbreak of respiratory disease associated with swine influenza H1N2 virus in pigs in Korea Serologic surveillance of swine H1 and H3 and avian H5 and H9 influenza A virus infections in swine population in Korea Genetic and antigenic characterization of swine H1N2 influenza viruses isolated from Korean pigs Isolation of influenza A(H3N2)v virus from pigs and characterization of its biological properties in pigs and mice Isolation and genetic characterization of H5N2 influenza viruses from pigs in Korea Isolation and phylogenetic analysis of H1N1 swine influenza virus isolated in Korea Phylogenetic analysis of swine influenza viruses recently isolated in Korea Isolation and characterization of novel H3N1 swine influenza viruses from pigs with respiratory diseases in Korea Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea Identification of reassortant pandemic H1N1 influenza virus in Korean pigs Phylogenetic analysis of a swine influenza A(H3N2) virus isolated in Korea in 2012 Serological evidence for influenza virus infection in Korean wild boars Complete Genome Sequence of H1N1 Swine Influenza Virus from Pigs in the Republic of Korea in 2016 Isolation and serological characterization of influenza A virus from a pig in Thailand The first isolation of swine H1N1 influenza viruses from pigs in Thailand Genetic diversity of swine influenza viruses isolated from pigs during 2000 to 2005 in Thailand. Inter-species transmission of equine influenza virus H3N8 from horse to swine in China expanded the genetic diversity of swine influenza viruses.
    keywords: a(h1n1)pdm09; antibodies; avian; farm; h1n1; h1n1 virus; h1n2; h3n2; h3n2 viruses; human; iav; infection; influenza; influenza virus; isolates; pandemic; pigs; reassortant; samples; swine; swine influenza; transmission; virus; viruses
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        item: #43 of 58
          id: cord-321112-w7x1dkds
      author: Zhao, Xuesen
       title: IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral Infections
        date: 2019-01-08
       words: 7019
      flesch: 30
     summary: Keywords: host susceptibility, interferon-induced transmembrane proteins, IFITM, single nucleotide polymorphisms, viral infection Interferon-induced transmembrane proteins (IFITMs) are a family of small proteins that can be found in single cell organisms and are evolutionally conserved across vertebrates (Siegrist et al., 2011; Zhang et al., 2012) . Among the number of single-nucleotide polymorphisms (SNPs) in IFITM3 gene that have been identified in human populations, several are associated with disease severity and prognosis of influenza A virus (IAV) and other viral infections (Everitt et al., 2012; Zhang et al., 2015; Xu-Yang et al., 2016; Allen et al., 2017) .
    keywords: activity; cells; entry; et al; fusion; human; iav; ifitm3; infection; influenza; interferon; proteins; rs12252; transmembrane; virus; viruses
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        item: #44 of 58
          id: cord-321673-v5o49ees
      author: Nieto-Torres, Jose L.
       title: Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis
        date: 2015-07-03
       words: 8415
      flesch: 34
     summary: Pore formation by nonstructural poliovirus 2B protein A potassium channel protein encoded by Chlorella virus PBCV-1 In vitro synthesis, tetramerization and single channel characterization of virus-encoded potassium channel Kcv Structural flexibility of the pentameric SARS coronavirus envelope protein ion channel Structure and inhibition of the SARS coronavirus envelope protein ion channel Three-dimensional structure of the channel-forming trans-membrane domain of virus protein u (Vpu) from HIV-1 Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors Reconstitution of the influenza virus M2 ion channel in lipid bilayers Correlation of the structural and functional domains in the membrane protein vpu from HIV-1 Direct measurement of the influenza a virus M2 protein ion channel activity in mammalian cells Proton conductance of influenza virus M2 protein in planar lipid bilayers Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment Syringomycin e channel: A lipidic pore stabilized by lipopeptide? The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding Influenza virus M2 protein mediates ESCRT-independent membrane scission Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein Ion channel activity of HIV-1 Vpu is dispensable for counteraction of CD317 Influenza A virus M2 ion channel activity is essential for efficient replication in tissue culture Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses Hexamethylene amiloride blocks E protein ion channels and inhibits
    keywords: activity; cell; channel; cov; ion; lipid; membranes; production; protein; sars; viroporins; virus; viruses
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        item: #45 of 58
          id: cord-322933-5xnxjqm5
      author: Murugaiah, Valarmathy
       title: Collectins: Innate Immune Pattern Recognition Molecules
        date: 2020-03-10
       words: 19410
      flesch: 32
     summary: A study by Madan et al. has focused on the susceptibility of SP-A −/− and SP-D −/− mice to challenge with A. fumigatus allergen compared to wild-type mice (Madan et al. 2005a, b) . The helix interacts with a neighbouring carbohydrate recognition domains (Kishore et al. 2006; Skjoedt et al 2012)
    keywords: activation; alveolar; binding; binds; cells; collectins; complement; conglutinin; et al; human; infection; interaction; lectin; levels; lung; macrophages; mannose; mbl; mice; phagocytosis; protein; protein d; pulmonary; receptor; recognition; response; serum; surface; surfactant; tuberculosis; type; virus
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        item: #46 of 58
          id: cord-324696-htx0ul4o
      author: Chothe, Shubhada K.
       title: Avian and human influenza virus compatible sialic acid receptors in little brown bats
        date: 2017-04-06
       words: 3890
      flesch: 43
     summary: Tissues sections from a total of 10 juvenile and 10 adult LBBs were subjected to lectin histochemistry for the detection of influenza virus receptors. A viruses A distinct lineage of influenza A virus from bats A distinct lineage of influenza A virus from bats Serological evidence of influenza A viruses in frugivorous bats from Africa Differences in influenza virus receptors in chickens and ducks: Implications for interspecies transmission Endocytosis of influenza viruses.
    keywords: avian; bats; gal; human; influenza; receptors; virus; viruses
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        item: #47 of 58
          id: cord-325192-italbsed
      author: Desai, Tanay M.
       title: IFITM3 Restricts Influenza A Virus Entry by Blocking the Formation of Fusion Pores following Virus-Endosome Hemifusion
        date: 2014-04-03
       words: 8298
      flesch: 46
     summary: hemifusion to both red blood cell and planar bilayer membranes Viral Membrane Fusion and Nucleocapsid Delivery into the Cytoplasm are Distinct Events in Some Flaviviruses Observation of single influenza virus-cell fusion and measurement by fluorescence video microscopy Diffusion and redistribution of lipid-like molecules between membranes in virus-cell and cell-cell fusion systems Membrane flux through the pore formed by a fusogenic viral envelope protein during cell fusion The pathway of membrane fusion catalyzed by influenza hemagglutinin: restriction of lipids, hemifusion, and lipidic fusion pore formation Singleparticle kinetics of influenza virus membrane fusion Fusion of Mature HIV-1 Particles Leads to Complete Release of a Gag-GFP-Based Content Marker and Raises the Intraviral pH Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease Lipid and cholesterol trafficking in NPC Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization pH-dependent hemolysis by influenza, Semliki, Forest virus, and Sendai virus The transport of low density lipoprotein-derived cholesterol to the plasma membrane is defective in NPC1 cells Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection Cholesterol promotes hemifusion and pore widening in membrane fusion induced by influenza hemagglutinin Sterols and sphingolipids strongly affect the growth of fusion pores induced by the hemagglutinin of influenza virus Multiphasic effects of cholesterol on influenza fusion kinetics reflect multiple mechanistic roles Non-vesicular lipid transport by lipid-transfer proteins and beyond Endosome-tocytosol transport of viral nucleocapsids Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport Imaging single retrovirus entry through alternative receptor isoforms and intermediates of virus-endosome fusion The lipid-anchored ectodomain of influenza virus hemagglutinin (GPI-HA) is capable of inducing nonenlarging fusion pores Restricted movement of lipid and aqueous dyes through pores formed by influenza hemagglutinin during cell fusion Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion Characterization of Lassa virus cell entry and neutralization with Lassa virus pseudoparticles Comprehensive analysis of ebola virus GP1 in viral entry Multifaceted mechanisms of HIV-1 entry inhibition by human alphadefensin We wish to thank Dr. David Steinhauer (Emory University) for the gift of R2376 antibody, Dr. Laura Liscum (Tufts University) for CHO-NPC1 2 cells, Dr. F.-L. Cosset (UniversitÃ© de Lyon, France) and Dr. L. Rong (University of Illinois) for Lassa virus and Ebola virus GP-expressing vectors, respectively. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes An enzymatic virus-like particle assay for sensitive detection of virus entry Membrane hemifusion: crossing a chasm in two leaps The energetics of membrane fusion from binding, through hemifusion, pore formation, and pore enlargement Visualizing infection of individual influenza viruses Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking GPI-anchored influenza hemagglutinin induces
    keywords: a549; cells; cholesterol; dequenching; entry; fig; fusion; hemifusion; iav; ifitm3; lipid; mdck; membrane; mixing; vdid; virus
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        item: #48 of 58
          id: cord-329680-ekxsv91t
      author: Yu, Yunjia
       title: Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways
        date: 2019-12-23
       words: 6924
      flesch: 53
     summary: Briefly, MDCK cells were infected with PA pretreated virus (Vir09, NWS, and PR8) at an moi of 0.001 pfu for 1 h at 37°C, and then subjected to plaque assay. 1b and c, PA treatment reduced the virus titers of Vir09, NWS, and PR8 in a dose-dependent manner when used at the concentrations of 6.25-50 μg/ mL. The 50% inhibitory concentration (IC 50 value) of PA for Vir09, NWS, and PR8 was about 6.3 ± 1.3, 3.5 ± 1.4, and 6.1 ± 1.7 μg/mL, respectively (Table 1) .
    keywords: anti; assay; cells; fig; iav; influenza; mice; treatment; virus
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        item: #49 of 58
          id: cord-332725-2oc1yrzx
      author: Kosmider, Beata
       title: Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus
        date: 2012-06-06
       words: 6691
      flesch: 43
     summary: The alveolar wall is covered primarily by ATI cells and these cells are more sensitive to oxidative injury than ATII cells. We observed caspase 1 and caspase 3 cleavage ( Figure 2 ) and also PARP cleavage (data not shown) in a concentration-dependent manner after ATIlike and ATII cell infection with PR8 virus at 24 hpi and 48 hpi.
    keywords: adnrf2; alveolar; apoptotic; ati; atii; cells; iav; infection; influenza; injury; nrf2; pr8; pr8 virus; virus
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        item: #50 of 58
          id: cord-333655-lylt7qld
      author: Van Breedam, Wander
       title: Bitter‐sweet symphony: glycan–lectin interactions in virus biology
        date: 2013-12-06
       words: 18704
      flesch: 25
     summary: Reading et al., 1997; Kase et al., 1999; Hartshorn et al., 2000; Hillaire et al., 2011) . Although SP-A may interact with some IAV isolates in a similar manner (Malhotra et al., 1994) , binding of this molecule to most of the IAV variants tested to date appears not to involve the lectin activity of SP-A; in contrast, virus binding depends on the interaction of the viral hemagglutinin with a sialylated N-glycan on the SP-A CRD (Hartshorn et al., 1994; Benne et al., 1995 Benne et al., , 1997 Hartshorn et al., 1997; van Eijk et al., 2003; Mikerov et al., 2008) .
    keywords: acid; activity; binding; cell; dendritic; eijk et; et al; glycan; glycosylation; gp120; hartshorn et; hemagglutinin; hiv; host; host lectins; human; iav; immune; infection; influenza; interactions; lectins; membrane; protein; receptors; recognition; sign; surface; target; type; virions; virus; viruses
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        item: #51 of 58
          id: cord-335871-zieuc7vk
      author: Brazee, Patricia L.
       title: Targeting the Linear Ubiquitin Assembly Complex to Modulate the Host Response and Improve Influenza A Virus Induced Lung Injury
        date: 2020-05-13
       words: 3746
      flesch: 28
     summary: We have reported that the amplitude of the inflammatory response is regulated by Linear Ubiquitin Assembly Complex (LUBAC) activity and that dampening of LUBAC activity is protective during severe influenza virus infection. Therapeutic modulation of LUBAC activity may be crucial to improve outcomes during severe influenza virus infection, as it functions as a molecular rheostat of the host response.
    keywords: host; iav; infection; influenza; linear; lubac; lung; response; ubiquitin; viral; virus
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        item: #52 of 58
          id: cord-338070-y8zi8iz9
      author: Liu, Wei
       title: Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice
        date: 2020-08-31
       words: 4129
      flesch: 43
     summary: Olaparib remarkably reduced IAV mRNA expression, myeloperoxidase (MPO) level, and inflammatory cell infiltration in IAV lungs. Moreover, olaparib significantly reduced the level of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-6, and IL-4 and increased IL-10 in IAV lungs.
    keywords: control; group; iav; infection; inflammatory; influenza; injury; lung; mice; olaparib; parp-1; virus
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        item: #53 of 58
          id: cord-339392-2ocz784l
      author: Sharma, Kulbhushan
       title: Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation
        date: 2011-06-15
       words: 6224
      flesch: 46
     summary: Likewise, Hsp40 is also known to regulate PKR signaling in influenza virus infected cells [25] . Apart from that, PKR activity is controlled by another mechanism where P58 IPK , the cellular inhibitor of PKR is activated in influenza virus infected cells [25, 28] .
    keywords: cells; fig; hsp40; iav; infection; influenza; inhibition; p58; phosphorylation; pkr; protein; virus
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        item: #54 of 58
          id: cord-342691-8jcfzexy
      author: Ochsner, Scott A.
       title: Consensus transcriptional regulatory networks of coronavirus-infected human cells
        date: 2020-09-22
       words: 10456
      flesch: 32
     summary: Per FAIR data best practice, CoV infection datasets -like all SPP datasetsare associated with detailed descriptions, assigned a DOI, and linked to the associated article to place the dataset in its original experimental context (Fig. 9D) . Like all SPP datasets, CoV infection datasets are comprehensively aligned with FAIR data best practice and feature human-readable names and descriptions, a DOI, one-click addition to citation managers, and machine-readable downloadable data files.
    keywords: cell; consensomes; cov; cov infection; data; fig; genes; hcts; human; iav; infection; intersection; mers; node; pathway; response; sars2; signaling; spp; transcriptional; values
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        item: #55 of 58
          id: cord-344093-3bniy5b5
      author: Peteranderl, Christin
       title: The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond
        date: 2017-03-22
       words: 12579
      flesch: 18
     summary: In addition, Davidson et al. (74) demonstrated that type I IFN application to IAVinfected mice increased morbidity and lung injury, which could be attributed to both DR5 and TRAIL upregulation inducing epithelial cell apoptosis. In line, Pinto et al. (92) reported an impairment of T cell responses upon type IFN induction in West Nile virus infection.
    keywords: activation; apoptosis; cells; death; disease; epithelial; expression; factor; iav; ifn; induction; infection; influenza; interferon; lung; protein; receptor; response; role; signaling; trail; type; virus
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        item: #56 of 58
          id: cord-347053-m5m4zgfy
      author: Pharo, Elizabeth A.
       title: Host–Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model
        date: 2020-06-24
       words: 9497
      flesch: 40
     summary: The interaction between respiratory pathogens and mucus Muc5b is required for airway defence The frontline defence of the lung Clinical aspects and cytokine response in severe H1N1 influenza A virus infection Influenza H5N1 and H1N1 virus replication and innate immune responses in bronchial epithelial cells are influenced by the state of differentiation Intensive cytokine induction in pandemic H1N1 influenza virus infection accompanied by robust production of IL-10 and IL-6 Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09 Inflammatory responses in influenza A virus infection The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts Genenames.org: The HGNC and VGNC resources in 2019 Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1 Innate immune recognition in infectious and noninfectious diseases of the lung Innate immunity in the lung: How epithelial cells fight against respiratory pathogens Collectins and cationic antimicrobial peptides of the respiratory epithelia Structure and function of the polymeric mucins in airways mucus Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway A review of inflammatory mechanism in airway diseases Respiratory epithelial cells as master communicators during viral infections Airway epithelial differentiation and mucociliary clearance Identification and functions of pattern-recognition receptors Pattern recognition receptors and inflammation Toll-like receptors and their crosstalk with other innate receptors in infection and immunity Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses Influenza virus activation of the interferon system The innate immune function of airway epithelial cells in inflammatory lung disease Respiratory epithelial cells in innate immunity to influenza virus infection A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape Interferon-stimulated genes: A complex web of host defenses Induction and evasion of type I interferon responses by influenza viruses Interferon-stimulated genes: What do they all do? Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): Role of the host immune response in pathogenesis Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza Integrated analysis of microRNA-mRNA expression in A549 cells infected with influenza A viruses (IAVs) from different host species IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications Synergistic up-regulation of CXCL10 by virus and IFN gamma in human airway epithelial cells Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection Modulating the innate immune response to influenza A virus: Influenza A viruses damage apical junctional complexes and alter the cell cytoskeleton and morphology of airway epithelial cells [34, 35, 83] .
    keywords: airway; cells; epithelium; expression; figure; h1n1pdm09; human; iav; infection; influenza; mock; pandemic; poly(i; response; teer; virus; vitro; wdnhbe
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        item: #57 of 58
          id: cord-347304-1o4fb3na
      author: Yang, Xiaoyun
       title: miR‐193b represses influenza A virus infection by inhibiting Wnt/β‐catenin signalling
        date: 2019-01-25
       words: 8649
      flesch: 48
     summary: Challenges and solutions MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells MicroRNA-142-3p negatively regulates canonical Wnt signaling pathway MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation The Frizzled family: Receptors for multiple signal transduction pathways MicroRNA roles in beta-catenin pathway MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability Influenza A virus NS1 induces G0/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein Deregulation of the MiR-193b-KRAS axis contributes to impaired cell growth in pancreatic cancer Influenza treatment and prophylaxis with neuraminidase inhibitors: A review. This is likely due to the combined effect of a reduced Wnt/β-catenin signalling activity and a direct repression by miR-193b because cyclin D1 is a well-known down-stream target of Wnt/β-catenin signalling (Shtutman et al., 1999) , and cyclin D1 has been previously shown to be a direct target of miR-193 in cancer cells (Chen et al., 2010) .
    keywords: a549; catenin; cells; con; expression; figure; iav; infection; influenza; mir-193b; mirnas; pathway; protein; signalling; vector; virus; wnt
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        item: #58 of 58
          id: cord-355931-3mvmetuv
      author: Nie, Chuanxiong
       title: Spiky nanostructures for virus inhibition and infection prevention
        date: 2020-07-16
       words: 2049
      flesch: 41
     summary: To this point, rationally designed virus entry inhibitors that block the viral interaction with its receptor can be novel strategies to prevent virus infection. Xanthium strumarium L Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition Influenza A Virus Hemagglutinin-Neuraminidase-Receptor Balance: Preserving Virus Motility Reverse design of an influenza neutralizing spiky nano-inhibitor with a dual mode of action Core-shell-structured MOF-derived 2D hierarchical nanocatalysts with enhanced Fenton-like activities Augmenting Intrinsic Fenton-Like Activities of MOF-Derived Catalysts via N-Molecule-Assisted Self-catalyzed Carbonization Metal-Organic-Framework-Derived 2D Carbon Nanosheets for Localized Multiple Bacterial Eradication and Augmented Anti-infective Therapy Metal-organic frameworks with photocatalytic bactericidal activity for integrated air cleaning Facile Synthesis of Uniform Viruslike Mesoporous Silica Nanoparticles for Enhanced Cellular Internalization Cell membrane-derived nanomaterials for biomedical applications Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties Nonchemotherapic and Robust Dual-Responsive Nanoagents with On-Demand Bacterial Trapping, Ablation, and Release for Efficient Wound Disinfection A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic Silica Nanopollens Enhance Adhesion for Long-Term Bacterial Inhibition Physical activation of innate immunity by spiky particles Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy Ultrasound-targeted microbubble destruction augmented synergistic therapy of rheumatoid arthritis via targeted liposomes Spiky nanoparticles that match the surface topography of virions are believed to be ideal scaffolds for virus inhibitors
    keywords: binding; figure; iav; inhibitor; spiky; virus
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