# bib

id: cord-263419-qeo6qn0d
author: Fiorino, Gionata
title: Protecting patients with IBD during the COVID-19 pandemic
date: 2020-05-20
extension: .txt
mime: text/plain
words: 418
sentence: 15
flesch: 30
cache: cache/cord-263419-qeo6qn0d.txt
txt: txt/cord-263419-qeo6qn0d.txt
summary:
  Vandoeuvreles Prevention of COVID-19 in patients with inflammatory bowel disease in Wuhan, China Inflammatory bowel disease care in the COVID-19 pandemic era: the Humanitas, Milan experience Management of IBD during the COVID-19 outbreak: resetting clinical priorities Systematic review with meta-analysis: comparative efficacy of immunosuppressants and biologics for reducing hospitalisation and surgery in Crohn's disease and ulcerative colitis Systematic review of effects of withdrawal of immunomodulators or biologic agents from patients with inflammatory bowel disease key: cord-263419-qeo6qn0d authors: Fiorino, Gionata; Peyrin-Biroulet, Laurent; Danese, Silvio title: Protecting patients with IBD during the COVID-19 pandemic date: 2020-05-20 journal: Lancet Gastroenterol Hepatol DOI: 10.1016/s2468-1253(20)30152-7 sha: doc_id: 263419 cord_uid: qeo6qn0d nan IBDs are immune-mediated diseases, which usually require treatment with corticosteroids, immunomodulators, or monoclonal antibodies to induce and maintain clinical and endoscopic remission.


id: cord-256143-9u5a0jqz
author: Grassia, Roberto
title: Inflammatory Bowel Diseases and Biological Treatment in SARS-CoV-2 Era. Why Not?
date: 2020-05-09
extension: .txt
mime: text/plain
words: 536
sentence: 29
flesch: 49
cache: cache/cord-256143-9u5a0jqz.txt
txt: txt/cord-256143-9u5a0jqz.txt
summary:
  Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Protection of 318 Inflammatory Bowel Disease Patients from the Outbreak and Rapid Spread of COVID-19 Infection in Wuhan AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary Uneventful course in IBD patients during SARS-CoV-2 outbreak in northern Italy Are patients with inflammatory bowel disease at increased risk for Covid-19 infection? Further studies are needed to investigate if IBD patients under biological treatment could be protected against the COVID-19 pneumonia, whereas those under immunosuppressive therapy (ie, thiopurines) could remain at higher risk of developing the disease due to the different mechanism of action.


id: cord-281275-i9920nvm
author: Schlabitz, Franziska
date: 2020-06-12
extension: .txt
mime: text/plain
words: 632
sentence: 26
flesch: 44
cache: cache/cord-281275-i9920nvm.txt
txt: txt/cord-281275-i9920nvm.txt
title:
  Inflammatory Bowel Disease and COVID-19—“Preventive” Sick Certificates as a Frequent Coping Strategy in the Face of the Pandemic

summary:
  Challenges in the care of IBD patients during the CoViD-19 pandemic: report from a Red Zone area in Northern Italy Coronavirus and IBD reporting database. Liberally issuing preventive sick certificates may be an exceptional strategy used for individual patients experiencing stressful life circumstances.


id: cord-288014-rrr4x755
author: Wang, Hong-Gang
title: Excessive anxiety in IBD patients is unnecessary for COVID-19
date: 2020-05-12
extension: .txt
mime: text/plain
words: 649
sentence: 28
flesch: 52
cache: cache/cord-288014-rrr4x755.txt
txt: txt/cord-288014-rrr4x755.txt
summary:
  key: cord-288014-rrr4x755 authors: Wang, Hong-Gang; Xie, Rui; Ma, Tian-Heng; Yang, Xiao-Zhong title: Excessive anxiety in IBD patients is unnecessary for COVID-19 date: 2020-05-12 journal: Clin Res Hepatol Gastroenterol DOI: 10.1016/j.clinre.2020.03.001 sha: doc_id: 288014 cord_uid: rrr4x755 nan Available online at ScienceDirect www.sciencedirect.com To the editor, Currently, 2019 novel coronavirus (SARS-CoV-2) infection disease (COVID-19) broke out in Wuhan, China and spread worldwide [1, 2] . Emotions are an important part of the management of IBD patients, because a less optimistic attitude can make their bowel symptoms recur [4] .


id: cord-258066-ncuegrq7
title: Inflammatory Bowel Disease
date: 2013-12-31
extension: .txt
mime: text/plain
words: 622
sentence: 33
flesch: 39
cache: cache/cord-258066-ncuegrq7.txt
txt: txt/cord-258066-ncuegrq7.txt
summary:
  Clinical immunology and immunopathology of the canine and feline intestine Alimentary and peritoneum Overview of biologic therapy for Crohn's disease Inflammatory bowel disease-live transmission Inflammatory bowel disease in veterinary medicine Treatment of inflammatory bowel disease (IBD) in dogs and cats Helicobacter mustelae-Associated Gastritis and Ulcers Hepatobiliary Disease Proliferative Bowel Disease Salmonellosis (Section VI) Clinical disease results from dysregulation of the mucosal immune response.


id: cord-283279-1qcdnd1y
author: Barberio, Brigida
date: 2020-07-17
extension: .txt
mime: text/plain
words: 662
sentence: 24
flesch: 39
cache: cache/cord-283279-1qcdnd1y.txt
txt: txt/cord-283279-1qcdnd1y.txt
title:
  The Adherence to Infusible Biologic Therapies in Inflammatory Bowel Disease Patients During COVID-19 Pandemic: Is It Really a Problem?

summary:
  The authors compared the adherence to infusion therapy between a cohort of IBD subjects, who received infusible biologic therapies during COVID-19, and another cohort of IBD patients who underwent the same therapies in 2019. Therefore, the rapid countermeasures adopted at many IBD centers, including ours, such as the implementation of telemedicine and distance education allowed to reassure IBD patients about the lack of risk related to COVID-19 infection.


id: cord-287885-1jwwmoys
author: D'Amico, Ferdinando
title: Views of patients with inflammatory bowel disease on the COVID-19 pandemic: a global survey
date: 2020-05-13
extension: .txt
mime: text/plain
words: 599
sentence: 16
flesch: 27
cache: cache/cord-287885-1jwwmoys.txt
txt: txt/cord-287885-1jwwmoys.txt
summary:
  The questionnaire was initially developed in English through the cooperation of IBD specialists and patient association representatives, focusing on the most frequent questions asked by patients during daily clinical practice. key: cord-287885-1jwwmoys authors: D'Amico, Ferdinando; Rahier, Jean-François; Leone, Salvo; Peyrin-Biroulet, Laurent; Danese, Silvio title: Views of patients with inflammatory bowel disease on the COVID-19 pandemic: a global survey date: 2020-05-13 journal: Lancet Gastroenterol Hepatol DOI: 10.1016/s2468-1253(20)30151-5 sha: doc_id: 287885 cord_uid: 1jwwmoys nan Patients with chronic diseases have experienced substantial changes to the routine management of their conditions during the coronavirus disease 2019 pandemic.


id: cord-266392-bayabroa
author: Brenner, Erica J.
date: 2020-10-12
extension: .txt
mime: text/plain
words: 1246
sentence: 53
flesch: 38
cache: cache/cord-266392-bayabroa.txt
txt: txt/cord-266392-bayabroa.txt
title:
  BENIGN EVOLUTION OF SARS-CoV2 INFECTIONS IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE: RESULTS FROM TWO INTERNATIONAL DATABASES

summary:
  A recent analysis in IBD patients from the SECURE-IBD registry revealed older age, steroid medication and comorbidities as risk factors for severe evolution, while the same study showed that the 29 IBD patients less 20 years had only mild disease courses. Bowel Disease (SECURE-IBD) and the COVID-19 database of the Paediatric IBD Porto group of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) were created in March 2020 with the aim to monitor outcomes of COVID-19 occurring in IBD patients.


id: cord-253001-xmcwuuk4
author: Papa, Alfredo
date: 2020-08-19
extension: .txt
mime: text/plain
words: 1456
sentence: 54
flesch: 40
cache: cache/cord-253001-xmcwuuk4.txt
txt: txt/cord-253001-xmcwuuk4.txt
title:
  Epidemiology and the Impact of Therapies on the Outcome of COVID-19 in Patients With Inflammatory Bowel Disease

summary:
  Uneventful course in IBD patients during SARS-CoV-2 outbreak in Northern Italy Prevention of COVID-19 in patients with inflammatory bowel disease in Wuhan, China SECURE-IBD database public data update Outcomes of COVID-19 in 79 patients with IBD in Italy: An IG-IBD study Characteristics and prognosis of patients with ixnflammatory bowel disease during the SARS-CoV-2 pandemic in the Basque Country (Spain), Gastroenterology 2020 Incidence and patterns of COVID-19 among inflammatory bowel disease patients from the Nancy and Milan cohorts novel coronavirus disease (COVID-19) in patients with inflammatory bowel diseases SARS-CoV-2 testing, prevalence, and predictors of COVID-19 in patients with inflammatory bowel disease in Northern California Impact of anti-TNF-a and thiopurines medications on the development of COVID-19 in patients with inflammatory bowel disease: A nationwide VA cohort study A fatal case of COVID-19 pneumonia occurring in a patient with severe acute ulcerative colitis Covid-19 infection in Crohn's disease under treatment with adalimumab Case report of a SARS-CoV-2 infection in a patient with ulcerative colitis on tofacitinib Up-regulation of IL-6 and TNF-alpha induced by SARS-coronavirus spike protein in murine macrophages via NF-kappaB pathway Expression of SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in the gut of patients with IBD The literature shows that the therapy's effect on COVID-19 outcome varies across patients (Table 1 ).


id: cord-295066-76se8mxq
author: Botti, Fiorenzo
date: 2020-08-31
extension: .txt
mime: text/plain
words: 1731
sentence: 57
flesch: 38
cache: cache/cord-295066-76se8mxq.txt
txt: txt/cord-295066-76se8mxq.txt
title:
  URGENT SURGERY FOR INFLAMMATORY BOWEL DISEASES DURING THE COVID-19 OUTBREAK IN A HIGH INCIDENCE AREA - EXPERIENCE FROM A HIGH-VOLUME CENTRE

summary:
  [5] We hereby report our experience on surgical management of IBD patients as a high-volume centre located in a high-incidence region for COVID-19. [4] As a tertiary referral centre for the surgical management of IBD patients, it was important to clearly define which complicated IBD cases were to be operated, by taking into account several variables including disease severity and quality of life, presence of comorbidities, feasibility of an alternative procedure.


id: cord-013370-gktnz644
author: Abreu, Maria T
date: 2020-10-21
extension: .txt
mime: text/plain
words: 1841
sentence: 68
flesch: 51
cache: cache/cord-013370-gktnz644.txt
txt: txt/cord-013370-gktnz644.txt
title:
  Providing Guidance During a Global Viral Pandemic for the Care of Patients With Inflammatory Bowel Disease

summary:
  We have tried to remain cognisant of the fact that the majority of IBD patients are being cared for by general gastroenterologists who are all doing their best during this epidemic to keep their patients, staff, and themselves safe from infection. We have recently published a study looking at the expression of the two receptors that are required for viral entry and found that, in IBD patients and in healthy people, these receptors called ACE2 and TMPRSS2 are both expressed in the gut.


id: cord-290750-85731og8
author: Danese, Silvio
title: Management of IBD during the COVID-19 outbreak: resetting clinical priorities
date: 2020-03-25
extension: .txt
mime: text/plain
words: 1800
sentence: 54
flesch: 37
cache: cache/cord-290750-85731og8.txt
txt: txt/cord-290750-85731og8.txt
summary:
  United Eur Update on COVID19 for Patients with Crohn's Disease and Ulcerative Colitis Implications of COVID-19 for patients with pre-existing digestive diseases Advice on the use of masks in the community, during home care and in health care settings in the context of the novel coronavirus (2019-nCoV) outbreak: interim guidance has served as a Consultant or speaker for Ethicon, Frankenman, Oasis, Pfizer, Takeda and Sofar. As timely surgery is the other mainstay of IBD care, it is of deep concern that stopping scheduled surgery completely for several weeks for patients with IBD (allowing only oncological cases to undergo surgery) will soon result in increased numbers of emergency presentations and more complications from treatment delay.


id: cord-275447-nx45kwn6
author: Ehrenpreis, Eli D.
title: Rapid Review: Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections
date: 2020-06-10
extension: .txt
mime: text/plain
words: 2353
sentence: 99
flesch: 41
cache: cache/cord-275447-nx45kwn6.txt
txt: txt/cord-275447-nx45kwn6.txt
summary:
  key: cord-275447-nx45kwn6 authors: Ehrenpreis, Eli D.; Kruchko, David H. title: Rapid Review: Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections date: 2020-06-10 journal: J Clin Gastroenterol DOI: 10.1097/mcg.0000000000001371 sha: doc_id: 275447 cord_uid: nx45kwn6 In the current COVID-19 pandemic, there has been concern regarding the use of ibuprofen and other nonsteroidal anti-inflammatory agents by COVID-19 infected patients. On March 14, the French Health Minister Olivier Véran, tweeted that taking anti-inflammatory drugs [ibuprofen (or) cortisone] could be an aggravating factor for the infection.


id: cord-285820-g8b7u3yf
author: Taxonera, Carlos
date: 2020-08-19
extension: .txt
mime: text/plain
words: 2798
sentence: 112
flesch: 40
cache: cache/cord-285820-g8b7u3yf.txt
txt: txt/cord-285820-g8b7u3yf.txt
title:
  Innovation in IBD Care During the COVID-19 Pandemic: Results of a Cross-Sectional Survey on Patient-Reported Experience Measures

summary:
  Telemedicine for Covid-19 AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines Opportunistic infections with anti-tumor necrosis factor-α therapy in inflammatory bowel disease: meta-analysis of randomized controlled trials Inflammatory bowel disease care in the COVID-19 pandemic era: the Humanitas, Milan experience Challenges in the care of IBD patients during the CoViD-19 pandemic: report from a Red Zone area in Northern Italy Maintaining the quality standards of care for inflammatory bowel disease patients during the COVID-19 pandemic Novel Coronavirus Disease (COVID-19) in patients with inflammatory bowel diseases Feasibility and acceptance of a home telemanagement system in patients with inflammatory bowel disease: a 6-month pilot study Telemedicine for management of inflammatory bowel disease (myIBDcoach): a pragmatic, multicentre, randomised controlled trial A randomized controlled trial of TELEmedicine for patients with inflammatory bowel disease (TELE-IBD) Delivering high value inflammatory bowel disease care through telemedicine visits Innovation in IBD care during the COVID-19 pandemic: results of a global telemedicine survey by the international organization for the study of inflammatory bowel disease Management of COVID-19 pandemic in Spanish inflammatory bowel disease units: results from a national survey The authors thank Dr. G. Morley for reviewing the English manuscript. 6, 7 Although several studies offer guidance on gold-standard strategies for improved care of IBD patients in western countries, outcomes of such strategies have not been evaluated.


id: cord-259585-mjtxiu0t
author: Occhipinti, Vincenzo
date: 2020-04-21
extension: .txt
mime: text/plain
words: 2806
sentence: 97
flesch: 40
cache: cache/cord-259585-mjtxiu0t.txt
txt: txt/cord-259585-mjtxiu0t.txt
title:
  Challenges in the Care of IBD Patients During the CoViD-19 Pandemic: Report From a “Red Zone” Area in Northern Italy

summary:
  As a tertiary care center for IBD patients and one of the most prominent in the Milan metropolitan area, our IBD center from the very beginning of the CoViD-19 pandemic has been hit with a daily onslaught of phone calls and e-mails from our patients with concerns as to how the situation may affect them. Anecdotally, IBD patients do not appear to be at higher risk of developing CoViD-19 compared with the general population.


id: cord-267260-8l831mre
author: Brenner, Erica J.
date: 2020-05-18
extension: .txt
mime: text/plain
words: 3149
sentence: 130
flesch: 38
cache: cache/cord-267260-8l831mre.txt
txt: txt/cord-267260-8l831mre.txt
title:
  Corticosteroids, but not TNF Antagonists, are Associated with Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results from an International Registry

summary:
  We sought to characterize the clinical course of COVID-19 among IBD patients and evaluate the association between demographics, clinical characteristics, and immunosuppressant treatments on COVID-19 outcomes. Methods Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of IBD patients with confirmed COVID-19.


id: cord-261029-befymalm
author: Sultan, Keith
title: Review of inflammatory bowel disease and COVID-19
date: 2020-10-07
extension: .txt
mime: text/plain
words: 3262
sentence: 136
flesch: 45
cache: cache/cord-261029-befymalm.txt
txt: txt/cord-261029-befymalm.txt
summary:
  The authors observed an incidence of COVID-19 positive IBD patients in the cohort of 0.0025, which was similar to the current cumulative incidence of 0.0017 in France and Italy at that time. As such, the risk of COVID-19, virus related outcomes, and appropriate management of IBD patients during the global pandemic is of immediate concern to gastroenterologists worldwide.


id: cord-269390-4yn8c34i
author: Rimondi, Alessandro
title: Fogging IBD Management: An Unusual Case of IBD Flare-up During the COVID-19 Outbreak
date: 2020-07-28
extension: .txt
mime: text/plain
words: 608
sentence: 25
flesch: 40
cache: cache/cord-269390-4yn8c34i.txt
txt: txt/cord-269390-4yn8c34i.txt
summary:
  4 Ageusia and anosmia have been reported in about one third of COVID-19 patients, 5 whereas they have rarely been observed in IBD patients. Challenges in the care of IBD patients during the CoViD-19 pandemic: report from a Red Zone area in Northern Italy AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis Endoscopy in inflammatory bowel diseases during the COVID-19 pandemic and postpandemic period Selfreported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study CT scan image showing a cross-sectioned descending colon (white arrow) with wall thickening and mucosal hyperenhancement.


id: cord-026792-jsqa4pmu
author: Samanta, Jayanta
title: 2019 Novel Coronavirus Infection: Gastrointestinal Manifestations
date: 2020-05-16
extension: .txt
mime: text/plain
words: 3797
sentence: 154
flesch: 43
cache: cache/cord-026792-jsqa4pmu.txt
txt: txt/cord-026792-jsqa4pmu.txt
summary:
  Data are not adequate yet to prove or disprove the theory of whether IBD patients are at an increased risk of infection in this COVID-19 era. The risk of SARS-CoV-2 in immunosuppressed IBD patients.


id: cord-027386-23exaaik
author: Rao, Vishwas
title: A Machine-Learning-Based Importance Sampling Method to Compute Rare Event Probabilities
date: 2020-05-25
extension: .txt
mime: text/plain
words: 4292
sentence: 232
flesch: 52
cache: cache/cord-027386-23exaaik.txt
txt: txt/cord-027386-23exaaik.txt
summary:
  SIAM Stochastic Simulation: Algorithms and Analysis Power system blackouts-literature review Estimation of small failure probabilities in high dimensions by subset simulation Rare-event simulation Bayesian subset simulation Efficient monte carlo simulation via the generalized splitting method Introduction to Rare Event Simulation Hybrid subset simulation method for reliability estimation of dynamical systems subject to stochastic excitation Reliability estimation for dynamical systems subject to stochastic excitation using subset simulation with splitting Rogue waves and large deviations in deep sea Extreme event quantification in dynamical systems with random components Exploring Monte Carlo methods Oceanic rogue waves Dram: efficient adaptive MCMC Estimation of particle transmission by random sampling Methods of reducing sample size in monte carlo computations A two-stage subset simulation-based approach for calculating the reliability of inelastic structural systems subjected to gaussian random excitations Geometric insight into the challenges of solving high-dimensional reliability problems Adam: a method for stochastic optimization Monte Carlo Strategies in Scientific Computing The monte carlo method A sequential sampling strategy for extreme event statistics in nonlinear dynamical systems Sequential sampling strategy for extreme event statistics in nonlinear dynamical systems Efficient computation of extreme excursion probabilities for dynamical systems Gaussian Processes for Machine Learning. 2 we review the existing literature for estimating rare event probabilities.


id: cord-280023-r3qgdgeu
author: Dipasquale, Valeria
title: Challenges in paediatric inflammatory bowel diseases in the COVID-19 time
date: 2020-04-08
extension: .txt
mime: text/plain
words: 1067
sentence: 42
flesch: 36
cache: cache/cord-280023-r3qgdgeu.txt
txt: txt/cord-280023-r3qgdgeu.txt
summary:
  We would like to emphasize the importance of addressing main concerns from IBD paediatric patients during the COVID-19 epidemic, taking into consideration their peculiar disease characteristics and comorbidity spectrum. In line with these observations, discontinuation (or at least tapering) of steroid treatment during COVID-19 epidemic may be a reasonable option.


id: cord-258930-60yn4hg7
author: D’Amico, Ferdinando
title: Inflammatory bowel diseases and COVID-19: the invisible enemy
date: 2020-04-16
extension: .txt
mime: text/plain
words: 1028
sentence: 27
flesch: 25
cache: cache/cord-258930-60yn4hg7.txt
txt: txt/cord-258930-60yn4hg7.txt
summary:
  Home patient management has been called telemedicine and it is a well-accepted approach by patients, as evidenced by the high adherence to home therapies or recommendations from physicians 22, 23 . Gut Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines IOIBD Update on COVID19 for Patients with Crohn's Disease and Ulcerative Colitis | IOIBD Management of IBD during the COVID-19 outbreak: resetting clinical priorities Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study European Crohn's and Colitis Organisation Topical Review on Treatment Withdrawal Facing Covid-19 in Italy -Ethics, Logistics, and Therapeutics on the Epidemic's Front Line Fair Allocation of Scarce Medical Resources in the Time of Covid-19 Implications of COVID-19 for patients with pre-existing digestive diseases Feasibility and acceptance of a home telemanagement system in patients with inflammatory bowel disease: a 6-month pilot study Telemedicine platform myIBDcoach reduces hospitalisations and outpatient gastroenterology visits in patients with IBD Amico declares no conflict of interest.


id: cord-284234-9cd2v6bt
author: Sebastian, S
title: Safety of drugs during previous and current coronavirus pandemics: Lessons for IBD
date: 2020-06-10
extension: .txt
mime: text/plain
words: 4490
sentence: 138
flesch: 29
cache: cache/cord-284234-9cd2v6bt.txt
txt: txt/cord-284234-9cd2v6bt.txt
summary:
  One of the key challenges needing addressing is the quantification of the risks of immunosuppressive and biologic therapies in IBD patients during the pandemic. Although clinical, immunological and pharmacological data from the experience with the previous coronavirus outbreaks cannot be automatically translated to predict the safety of IBD therapies during COVID-19 pandemic, the signals so far from these outbreaks on IBD patients who are on immunomodulators and biologics are reassuring to patients and clinicians alike.


id: cord-306325-9alfvda1
author: Galmozzi, E.
title: Letter: does the IFNL4 gene discovery really provide a causal role for the IL28B haplotype blocks?
date: 2014-02-04
extension: .txt
mime: text/plain
words: 1009
sentence: 31
flesch: 32
cache: cache/cord-306325-9alfvda1.txt
txt: txt/cord-306325-9alfvda1.txt
summary:
  Sleep disturbance and risk of active disease in patients with Crohn's disease and ulcerative colitis Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients Vitamin D deficiency and depression in adults: systematic review and metaanalysis The link between vitamin D metabolism and sleep medicine Polymorphisms of interferon-k4 and IL28B -effects on treatment response to interferon/ribavirin in patients with chronic hepatitis C A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus IL28B expression depends on a novel TT/-G polymorphism which improves HCV clearance prediction Interferon lambda 4 signals via the IFNk receptor to regulate antiviral activity against HCV and coronaviruses Blockade of chronic type I interferon signaling to control persistent LCMV infection ACKNOWLEDGEMENT Declaration of personal and funding interests: None. Declaration of personal and funding interests: None. SIRS, We thank Dr Galmozzi and Dr Lampertico for their comment on our recently published paper on the effect of the dinucleotide frameshift variant in ss469415590 in the interferon (IFN)-k4 gene on interferon/ribavirin treatment and its relationship with the two commonly used single nucleotide polymorphisms (SNP) in IL28B (rs12979860, rs8099917). Although validation studies in large cohorts of patients, like the one investigated by St€ attermayer et al., 1 may help understand the clinical utility of IFNL4, these studies have so far failed to demonstrate any causal rela-tionship between IFNL4 protein and nonresponse to interferon therapy in chronic HCV patients.


id: cord-311162-kbqh7beq
author: Behzad, Catherine
date: 2020-09-09
extension: .txt
mime: text/plain
words: 496
sentence: 16
flesch: 40
cache: cache/cord-311162-kbqh7beq.txt
txt: txt/cord-311162-kbqh7beq.txt
title:
  Establishing Safe Out-of-Hospital Infusion Centers May Improve the Quality of Care in Patients With IBD During the COVID-19 Pandemic

summary:
  key: cord-311162-kbqh7beq authors: Behzad, Catherine; Taheri, Hassan; Kashifard, Mehrdad title: Establishing Safe Out-of-Hospital Infusion Centers May Improve the Quality of Care in Patients With IBD During the COVID-19 Pandemic date: 2020-09-09 journal: Inflamm Bowel Dis DOI: 10.1093/ibd/izaa246 sha: doc_id: 311162 cord_uid: kbqh7beq nan We read with great interest the article by Occhipinti and Pastorelli 1 about the challenges in the care of patients with inflammatory bowel disease (IBD) during the COVID-19 pandemic. Challenges in the care of IBD patients during the CoViD-19 pandemic: report from a Red Zone area in Northern Italy Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review Current status of multiple drug molecules, and vaccines: an update in SARS-CoV-2 therapeutics Offline: the second wave


id: cord-032753-icteg34y
author: Namai, Fu
date: 2020-09-28
extension: .txt
mime: text/plain
words: 5321
sentence: 231
flesch: 45
cache: cache/cord-032753-icteg34y.txt
txt: txt/cord-032753-icteg34y.txt
title:
  Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice

summary:
  Oral administration of NZ-IL1Ra to acute colitis mice alleviated colitis symptoms and suppressed excessive immune reactions in the intestinal tract and MLNs. The soluble fraction from the crushed cell pellet and supernatant collected from NZ-IL-1Ra incubated for 48 h was diluted using TBS + PIC and subjected to ELISA (Mouse IL-1Ra/IL-1F3 ELISA, R&D Systems, Minneapolis, MN, USA).


id: cord-285426-iyl12ber
author: Ghavami, Shaghayegh Baradaran
date: 2020-09-08
extension: .txt
mime: text/plain
words: 1974
sentence: 78
flesch: 40
cache: cache/cord-285426-iyl12ber.txt
txt: txt/cord-285426-iyl12ber.txt
title:
  IBD Patients Could Be Silent Carriers for Novel Coronavirus and Less Prone to its Severe Adverse Events: True or False?

summary:
  Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities Inflammatory bowel disease: between genetics and microbiota Care of inflammatory bowel disease patients in remission Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Evidence for gastrointestinal infection of SARS-CoV-2 Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents Viruses and interferon: a fight for supremacy Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease SARS coronavirus and innate immunity Cross-regulation of TNF and IFN-α in autoimmune diseases Are patients with inflammatory bowel disease at increased risk for Covid-19 infection? key: cord-285426-iyl12ber authors: Ghavami, Shaghayegh Baradaran; Shahrokh, Shabnam; Hossein-Khannazer, Nikoo; Shpichka, Anastasia; Asadzadeh Aghdaei, Hamid; Timashev, Peter; Vosough, Massoud title: IBD Patients Could Be Silent Carriers for Novel Coronavirus and Less Prone to its Severe Adverse Events: True or False? date: 2020-09-08 journal:


id: cord-275199-y7b12vml
author: Suárez-Fariñas, Mayte
date: 2020-09-25
extension: .txt
mime: text/plain
words: 5705
sentence: 199
flesch: 35
cache: cache/cord-275199-y7b12vml.txt
txt: txt/cord-275199-y7b12vml.txt
title:
  Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

summary:
  Compared to baseline ACE2 expression, post-infliximab (week 6) colonic ACE2 gene expression was significantly lower and this decrease was observed predominantly in endoscopic responders ( Figure S5 ). Consistent with the protein data, ACE2 gene expression was higher in the uninflamed ileum compared to the uninflamed colon or rectum.


id: cord-276267-77903fld
author: Al‐Ani, Aysha H.
title: Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient
date: 2020-05-26
extension: .txt
mime: text/plain
words: 5501
sentence: 197
flesch: 30
cache: cache/cord-276267-77903fld.txt
txt: txt/cord-276267-77903fld.txt
summary:
  The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients Risk factors for opportunistic infections in patients with inflammatory bowel disease Clinical assessment of risk factors for infection in inflammatory bowel disease patients Methods to avoid infections in patients with inflammatory bowel disease Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths Letter: Covid-19, and vitamin D Letter: Covid-19 and vitamin D-authors' reply Quantitative proteomic analysis reveals the deregulation of nicotinamide adenine dinucleotide metabolism and CD38 in inflammatory bowel disease Protection of 318 inflammatory bowel disease patients from the outbreak and rapid spread of COVID-19 infection in Wuhan Secure-IBD Database Public Data Update Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China CDC_AA_refVa l=https %3A%2F%2Fwww.cdc.gov%2F-cor onavi rus%2F201 9-ncov%2Fcli nical -crite ria Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines SARS: systematic review of treatment effects Corticosteroid therapy for critically Ill patients with middle east respiratory syndrome The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis Factors associated with psychosis among patients with severe acute respiratory syndrome: a case-control study Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Glucocorticoid-induced diabetes in severe acute respiratory syndrome: the impact of high dosage and duration of methylprednisolone therapy Relationship between glucocorticoid receptor and deficiency syndrome and the regulation of traditional Chinese medicine Increased risk of influenza and influenza-related complications among 140,480 patients with inflammatory bowel disease Increased risk of pneumonia among patients with inflammatory bowel disease Prevention of infection caused by immunosuppressive drugs in gastroenterology The historical role and contemporary use of corticosteroids in inflammatory bowel disease Budesonide for maintenance of remission in Crohn's disease Efficacy and safety of oral beclomethasone dipropionate in ulcerative colitis: a systematic review and meta-analysis Oral prolonged release beclomethasone dipropionate and prednisone in the treatment of active ulcerative colitis: results from a double-blind, randomized, parallel group study Comparative safety of systemic and low-bioavailability steroids in inflammatory bowel disease: Systematic review and network meta-analysis Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus Risk of infection with methotrexate therapy in inflammatory diseases: a systematic review and meta-analysis Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT registry Risk for overall infection with anti-TNF and anti-integrin agents used in IBD: a systematic review and meta-analysis Comparative risk of serious infections with biologic and/or immunosuppressive therapy in patients with inflammatory bowel diseases: a systematic review and meta-analysis Anti-TNF-alpha therapy for patients with sepsis: a systematic meta-analysis Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection Ustekinumab as induction and maintenance therapy for Crohn's disease Risk of serious infection with biologic and systemic treatment of psoriasis: results from the psoriasis longitudinal assessment and registry IM-UNITI: three-year efficacy, safety, and immunogenicity of ustekinumab treatment of Crohn's disease Systematic review: the safety of vedolizumab for the treatment of inflammatory bowel disease Safety profile of biologic drugs in the therapy of Crohn disease: a systematic review and network meta-analysis Safety profile of biologic drugs in the therapy of ulcerative colitis: a systematic review and network meta-analysis The safety of vedolizumab for ulcerative colitis and Crohn's disease Differential expression of adhesion molecules and chemokines between nasal and small intestinal mucosae: implications for T-and sIgA+ B-lymphocyte recruitment Switch to adalimumab in patients with Crohn's disease controlled by maintenance infliximab: prospective randomised SWITCH trial Herpes zoster infection in patients with ulcerative colitis receiving tofacitinib Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study Tofacitinib as induction and maintenance therapy for ulcerative colitis Growing evidence of the safety of JAK inhibitors in patients with rheumatoid arthritis Real-world experience with tofacitinib in IBD at a Tertiary Center COVID-19: combining antiviral and anti-inflammatory treatments Guidance for discharge and ending isolation in the context of widespread community transmission of COVID-19 -first update Infection-related hospitalizations are associated with increased mortality in patients with inflammatory bowel diseases Nonpharmaceutical measures for pandemic influenza in nonhealthcare settings-social distancing measures Effectiveness of workplace social distancing measures in reducing influenza transmission: a systematic review Virtually perfect? In China healthcare workers made up 3.5% of COVID-19 patients and Italy have reported that 20% of its responding healthcare work force is being infected.


id: cord-311804-39mu0tdr
author: Zingone, Fabiana
date: 2020-04-10
extension: .txt
mime: text/plain
words: 867
sentence: 28
flesch: 22
cache: cache/cord-311804-39mu0tdr.txt
txt: txt/cord-311804-39mu0tdr.txt
title:
  Screening for Active COVID-19 Infection and Immunization Status Prior to Biologic Therapy in IBD Patients at the Time of the Pandemic Outbreak

summary:
  A viral screen is commonly suggested before starting biologics (8) due to the higher risk of serious and opportunistic infections in IBD patients (9) (10) (11) , that becomes particularly high in patients older than 50 years (12,13). British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults Opportunistic infections with anti-tumor necrosis factoralpha therapy in inflammatory bowel disease: meta-analysis of randomized controlled trials Crohn's Disease Activity and Concomitant Immunosuppressants Affect the Risk of Serious and Opportunistic Infections in Patients Treated With Adalimumab First-and Second-line Pharmacotherapies for Patients with Moderate to Severely Active Ulcerative Colitis: An Updated Network Meta-Analysis Risk factors for opportunistic infections in patients with inflammatory bowel disease Viral screening before initiation of biologics in patients with inflammatory bowel disease during the COVID-19 outbreak COVID-19: consider cytokine storm syndromes and immunosuppression Immunosuppression for hyperinflammation in COVID-19: a double-edged sword? Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study


id: cord-285238-bpk3xl8x
author: Dong, Xiuli
title: Intestinal and Peripheral Fibrinogen-Like Protein 2 Expression in Inflammatory Bowel Disease
date: 2013-11-28
extension: .txt
mime: text/plain
words: 3462
sentence: 151
flesch: 41
cache: cache/cord-285238-bpk3xl8x.txt
txt: txt/cord-285238-bpk3xl8x.txt
summary:
  Western blot analysis revealed that FGL2 protein expression, normalized against GAPDH, in PBMC was 0.738 ± 0.386 (95 % CI 0.593-0.882) for patients with UC, and 0.907 ± 0.3686 (95 % CI 0.767-1.0469) for patients with CD, compared with 0.662 ± 0.311 (95 % CI 0.546-0.778) for controls. FGL2 expression in mucosal biopsies from three groups (UC group (n = 61), CD group (n = 54), and controls group (n = 35)) was detected by immunohistochemistry.


id: cord-266648-962r0vm8
author: Grossberg, Laurie B
date: 2020-07-03
extension: .txt
mime: text/plain
words: 3618
sentence: 154
flesch: 42
cache: cache/cord-266648-962r0vm8.txt
txt: txt/cord-266648-962r0vm8.txt
title:
  Review of Societal Recommendations Regarding Management of Patients With Inflammatory Bowel Disease During the SARS-CoV-2 Pandemic

summary:
  Coronavirus (COVID-19): what IBD patients should know About Crohn's & colitis: COVID-19 and IBD. Coronavirus (COVID-19) response Management of inflammatory bowel disease patients in the COVID-19 pandemic era: a Brazilian tertiary referral center guidance Joint GI society message on COVID-19 Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1 Evidence for gastrointestinal infection of SARS-CoV-2 Prolonged presence of SARS-CoV-2 viral RNA in faecal samples Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding Detection of SARS-CoV-2 in different types of clinical specimens Virological assessment of hospitalized patients with COVID-2019 European Crohn's and Colitis Organisation.


id: cord-306859-aqfgl9cm
author: Clough, Jennie N
date: 2020-06-27
extension: .txt
mime: text/plain
words: 519
sentence: 18
flesch: 43
cache: cache/cord-306859-aqfgl9cm.txt
txt: txt/cord-306859-aqfgl9cm.txt
title:
  Managing an IBD Infusion Unit During the COVID-19 Pandemic: Service Modifications and the Patient Perspective

summary:
  Overall, only 20.6% of patients reported being quite or very concerned about access to IBD services over the next 3-6 months, but levels of anxiety were significantly higher about the impact of the pandemic in general (Fig. 1) . Given the recommendation for patients to remain on their usual biologic medication wherever possible, 1 we modified our service to ensure that our patients were adequately protected on the unit and surveyed attenders regarding their views and concerns.


id: cord-306760-05my504t
author: Turner, Dan
date: 2020-03-31
extension: .txt
mime: text/plain
words: 3841
sentence: 167
flesch: 42
cache: cache/cord-306760-05my504t.txt
txt: txt/cord-306760-05my504t.txt
title:
  Corona Virus Disease 2019 and Paediatric Inflammatory Bowel Diseases: Global Experience and Provisional Guidance (March 2020) from the Paediatric IBD Porto Group of European Society of Paediatric Gastroenterology, Hepatology, and Nutrition

summary:
  A questionnaire was sent on March 20, 2020 to 19 paediatric gastroenterology centers in China to evaluate the impact of COVID-19 on the prognosis of IBD children. On the basis of currently (March 2020) available limited data presented here, we suggest the following: IBD children, with and without immunosuppressive and biological therapy, do not seem to carry a higher risk of SARS-CoV-2 infection, compared with the general population.


id: cord-302717-hn3airxq
author: Bayoumy, Ahmed B.
date: 2020-09-11
extension: .txt
mime: text/plain
words: 6511
sentence: 290
flesch: 51
cache: cache/cord-302717-hn3airxq.txt
txt: txt/cord-302717-hn3airxq.txt
title:
  Efficacy, safety and drug survival of thioguanine as maintenance treatment for inflammatory bowel disease: a retrospective multi-centre study in the United Kingdom

summary:
  Common Terminology Criteria for Adverse Events (CTCAE) Version 5 The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies Revising the Declaration of Helsinki Efficacy of thioguanine treatment in inflammatory bowel disease: a systematic review 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients The prevalence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with thioguanine is not associated with clinically significant liver disease Histopathology of liver biopsies from a thiopurine-naive inflammatory bowel disease cohort: prevalence of nodular regenerative hyperplasia Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules Nodular regenerative hyperplasia in patients with inflammatory bowel disease treated with azathioprine Review article: the association between nodular regenerative hyperplasia, inflammatory bowel disease and thiopurine therapy Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients Clinical course of nodular regenerative hyperplasia in Thiopurine treated inflammatory bowel disease patients Nodular regenerative hyperplasia of the liver: survival and associated features in a UK case series Systematic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease The aim of this study was to investigate the long-term efficacy and safety of low-dose TG therapy in IBD patients failing AZA and MP.


id: cord-297768-tjqpiyp1
author: Day, Alice S.
date: 2020-07-20
extension: .txt
mime: text/plain
words: 1181
sentence: 40
flesch: 36
cache: cache/cord-297768-tjqpiyp1.txt
txt: txt/cord-297768-tjqpiyp1.txt
title:
  Practical guidance for dietary management of patients with inflammatory bowel disease during the SARS-CoV2 pandemic

summary:
  6, 7 It must 55 be acknowledged that it is unlikely any high quality evidence will allow timely production of 56 guidelines specific for IBD patients during the COVID-19 pandemic, so observational data 57 and anecdotal lessons learned from the first countries affected by the novel coronavirus are 58 providing direction for the rest of the world. Consider telehealth dietetic consultation for IBD patients to ensure safe and equitable access to dietetic services during this pandemic, the cost of which may be mitigated by Government supported healthcare schemes.


id: cord-031937-qhlatg84
author: Verma, Anukriti
date: 2020-09-15
extension: .txt
mime: text/plain
words: 6766
sentence: 210
flesch: 19
cache: cache/cord-031937-qhlatg84.txt
txt: txt/cord-031937-qhlatg84.txt
title:
  Elucidating potential molecular signatures through host-microbe interactions for reactive arthritis and inflammatory bowel disease using combinatorial approach

summary:
  KYNU was further mapped with host proteins (direct and indirect) resulting in 1994 interactions. It is suggested that in host-microbe interactions, bacterial proteins entering host cells interact with host proteins and inject their effector components, but has not been proven in ReA and IBD.


id: cord-288439-srzysoqy
author: Segal, Jonathan P.
date: 2020-09-03
extension: .txt
mime: text/plain
words: 6855
sentence: 263
flesch: 31
cache: cache/cord-288439-srzysoqy.txt
txt: txt/cord-288439-srzysoqy.txt
title:
  Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease

summary:
  Specifically, when considering IBS, small-bowel microbiota alterations have been associated with symptoms, 83 and hence future studies will need to explore the role of the small-bowel microbiota in efficacy of FMT. Data from non-CDI FMT studies such as in IBD have demonstrated that some recipients of FMT have an exceptional response while others do not. Another major consideration is that diet plays a large influence on the gut microbiota and hence is likely to affect the donation and FMT efficacy.


id: cord-310042-9z8rkzq8
author: Aysha, Al‐Ani
date: 2020-07-12
extension: .txt
mime: text/plain
words: 3473
sentence: 151
flesch: 37
cache: cache/cord-310042-9z8rkzq8.txt
txt: txt/cord-310042-9z8rkzq8.txt
title:
  Practical management of inflammatory bowel disease patients during the COVID‐19 pandemic: expert commentary from the Gastroenterological Society of Australia Inflammatory Bowel Disease faculty

summary:
  A significant proportion of IBD patients are treated with long-term immunomodulator/immunosuppressive therapy which potentially places them at increased risk of infections and associated complications. Despite concerns regarding immunosuppression and consequent predisposition to infection, there is no evidence to suggest increased infection rates of COVID-19 in IBD patients to date.


id: cord-300963-1n1f8mf2
author: Gajendran, Mahesh
date: 2020-10-12
extension: .txt
mime: text/plain
words: 6697
sentence: 294
flesch: 43
cache: cache/cord-300963-1n1f8mf2.txt
txt: txt/cord-300963-1n1f8mf2.txt
title:
  Inflammatory bowel disease amid the COVID-19 pandemic: impact, management strategies, and lessons learned

summary:
  Patients with COVID-19 have lymphopenia, whereas in IBD patients, lymphocyte levels are usually normal or elevated. Hence, there is an ongoing concern over the impact of COVID-19 on IBD patients and their susceptibility to it.


id: cord-307201-keec6fzo
author: Barberio, Brigida
title: Should IBD Patients Be Tested for Active COVID-19 Prior Starting a Biological Treatment?
date: 2020-08-30
extension: .txt
mime: text/plain
words: 656
sentence: 23
flesch: 31
cache: cache/cord-307201-keec6fzo.txt
txt: txt/cord-307201-keec6fzo.txt
summary:
  In particular, although available data do not support an increased risk of contracting COVID-19 infection in IBD patients, the international Surveillance Epidemiology of Coronavirus Under Research Exclusion (SECURE)-IBD registry reports a not reassuring 4% of case fatality rate and hospitalization in nearly one third of patients. Medications, in particular, is a priority area and the COVID-19 pandemic has led to challenging decision-making about treatment in IBD patients.


id: cord-337204-14gxpeaf
author: Piciucchi, Matteo
date: 2020-05-25
extension: .txt
mime: text/plain
words: 1641
sentence: 70
flesch: 38
cache: cache/cord-337204-14gxpeaf.txt
txt: txt/cord-337204-14gxpeaf.txt
title:
  Preliminary considerations regarding the risk of COVID-19 and disease severity in chronic gastrointestinal conditions

summary:
  Similarly, chronic pneumopathy, chronic kidney diseases, immunosuppression, and oncological conditions were found to be highly prevalent in COVID-19 patients, especially in those who progress to SARS and require intensive care A retrospective analysis of data from 1590 hospitalized COVID-19 patients in epicentral and nonepicentral areas of China did not show a high prevalence of preexistent chronic GI comorbidities in these patients [7] .


id: cord-312663-hhd5f823
author: Fiorino, Gionata
title: Inflammatory Bowel Disease Care in the COVID-19 Pandemic Era: The Humanitas, Milan, Experience
date: 2020-03-24
extension: .txt
mime: text/plain
words: 2206
sentence: 95
flesch: 49
cache: cache/cord-312663-hhd5f823.txt
txt: txt/cord-312663-hhd5f823.txt
summary:
  Specific web pages are available to give patients updated information on COVID-19 for IBD patients. We aim to give a viewpoint on how operationally to manage IBD patients and ensure quality of care in the current pandemic era.


id: cord-312374-gu9tq48n
author: Martin Arranz, Eduardo
date: 2020-06-04
extension: .txt
mime: text/plain
words: 2490
sentence: 105
flesch: 43
cache: cache/cord-312374-gu9tq48n.txt
txt: txt/cord-312374-gu9tq48n.txt
title:
  Management of COVID-19 Pandemic in Spanish Inflammatory Bowel Disease Units: Results From a National Survey

summary:
  Thirteen doctors (24%) attend patients in monographic IBD clinics, and the rest of the surveyed doctors (5, 9.3%) usually attend IBD patients but only in general consultation (Fig. 2 ). Regarding the management of IBD patients contacting their physicians with mild symptoms suggesting COVID-19, 92.6% of surveyed IBD units referred patients to their primary care physician or the emergency department; of these, 28% (14 sites) referred all immunosuppressed patients to the emergency department and 10% (5 sites) referred all IBD patients regardless of their current treatment.


id: cord-255930-2bobmkvu
author: Kaplan, Gilaad G.
title: The four epidemiological stages in the global evolution of inflammatory bowel disease
date: 2020-10-08
extension: .txt
mime: text/plain
words: 9028
sentence: 294
flesch: 35
cache: cache/cord-255930-2bobmkvu.txt
txt: txt/cord-255930-2bobmkvu.txt
summary:
  By contrast, some studies have found that IBD incidence in children 38 , including IBD of very early onset 39 , has increased in the Western world over the past two decades. Although prevalence is anticipated to increase over the next decade, as regions transition to the fourth stage, the steep slope of prevalence will decline, leading to a lengthening of Prevalence Incidence True Rise in Incidence (environmental) Unmasking of Incidence (economic) Fig. 3 | the interplay and determinants of IBD incidence, prevalence and mortality.


id: cord-017342-qsfykh1k
author: Nedelsky, Natalia B.
date: 2013-06-21
extension: .txt
mime: text/plain
words: 8843
sentence: 309
flesch: 28
cache: cache/cord-017342-qsfykh1k.txt
txt: txt/cord-017342-qsfykh1k.txt
title:
  Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics

summary:
  Fatty acid-induced NLRP3-ASC infl ammasome activation interferes with insulin signaling Crohn's disease-associated ATG16L1 polymorphism modulates pro-infl ammatory cytokine responses selectively upon activation of NOD2 Autophagy suppresses interleukin-1beta (IL-1beta) signaling by activation of p62 degradation via lysosomal and proteasomal pathways Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility Network organization of the human autophagy system Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1 Selective autophagy: ubiquitin-mediated recognition and beyond Identifying the proteins to which small-molecule probes and drugs bind in cells The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease Small molecule regulators of autophagy identifi ed by an image-based high-throughput screen Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling Small molecules enhance autophagy and reduce toxicity in Huntington's disease models Identifi cation of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic fl ux Chemical modulators of autophagy as biological probes and potential therapeutics Complex inhibitory effects of nitric oxide on autophagy Metabolic regulation by HMGB1-mediated autophagy and mitophagy Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34 Acknowledgments This work was supported by funding from the Crohn's and Colitis Foundation of America and NIH grants DK043351, DK083756, and DK086502 to R.J.X. As highlighted throughout this chapter, many unanswered questions remain regarding the mechanistic basis of multiple autophagy functions.


id: cord-351566-z6onmkrn
author: Bezzio, Cristina
date: 2020-06-16
extension: .txt
mime: text/plain
words: 474
sentence: 20
flesch: 41
cache: cache/cord-351566-z6onmkrn.txt
txt: txt/cord-351566-z6onmkrn.txt
title:
  SEVERE IBD FLARES AND COVID-19: EXPAND THE GASTROENTEROLOGY-SURGERY TEAM TO INCLUDE AN INFECTIOUS DISEASE SPECIALIST

summary:
  Perhaps because of the lack of empirical evidence, these guidelines did not specifically address the challenging case of IBD patients hospitalized due to a severe flare of disease with subsequent or concomitant pneumonia due to SARS-CoV-2. Nonetheless, we think that the issues raised by this case are of great interest to physicians managing IBD patients during the COVID-19 pandemic.


id: cord-021852-o0k2r0yo
author: Simpson, Kenneth W.
title: The Role of the Microbiota in Feline Inflammatory Bowel Disease
date: 2015-12-04
extension: .txt
mime: text/plain
words: 3668
sentence: 136
flesch: 25
cache: cache/cord-021852-o0k2r0yo.txt
txt: txt/cord-021852-o0k2r0yo.txt
summary:
  From a clinical perspective, it seems wise to adopt a Characterization of fecal microbiota in cats using universal 16S rRNA gene and group-specific primers for Lactobacillus and Bifidobacterium spp Assessment of microbial diversity along the feline intestinal tract using 16S rRNA gene analysis Pitfalls and progress in the diagnosis and management of canine inflammatory bowel disease Food sensitivity in cats with chronic idiopathic gastrointestinal problems Subnormal concentrations of serum cobalamin (vitamin B 12 ) in cats with gastrointestinal disease Feline idiopathic inflammatory bowel disease: what we know and what remains to be unraveled Ultrasonographic thickening of the muscularis propria in feline small intestinal small cell T-cell lymphoma and inflammatory bowel disease Pancreatitis and triaditis in cats: causes and treatment The distribution of leucocyte subsets in the small intestine of healthy cats Outcome of cats with low-grade lymphocytic lymphoma: 41 cases Feline gastrointestinal lymphoma: mucosal architecture, immunophenotype, and molecular clonality Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease Unraveling the ties between celiac disease and intestinal microbiota Intestinal T-cell responses in celiac diseaseimpact of celiac disease associated bacteria The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease Evaluation of fluorescence in situ hybridization for the detection of bacteria in feline inflammatory liver disease 15 FISHbased studies of duodenal mucosa-associated bacteria in healthy cats have shown that the majority of bacteria are present in free and adherent mucus, with a median of 48 low-grade, T-cell, alimentary lymphoma in cats means that careful consideration has to be given to the number and regional distribution of mucosa-associated lymphocytes (e.g., clusters of intraepithelial lymphocytes) to enable distinction between lymphoplasmacytic enteritis and lymphoma.


id: cord-307769-rjseio5s
author: Sim, Winnie H
title: Expression profile of genes involved in pathogenesis of pediatric Crohn's disease
date: 2012-05-24
extension: .txt
mime: text/plain
words: 4681
sentence: 186
flesch: 33
cache: cache/cord-307769-rjseio5s.txt
txt: txt/cord-307769-rjseio5s.txt
summary:
  (125 fg) of each gene was used as the calibrator in every assay to allow for direct comparison of gene expression for all samples analyzed across multiple assays. The Mann-Whitney U-test was used to compare the difference in median values between gene expression in CD and non-IBD patient samples.


id: cord-331703-4hwmajt3
author: Occhipinti, Vincenzo
title: Impact of COVID-19 outbreak on the management of patients with severe IBD: a domino effect
date: 2020-05-12
extension: .txt
mime: text/plain
words: 773
sentence: 29
flesch: 38
cache: cache/cord-331703-4hwmajt3.txt
txt: txt/cord-331703-4hwmajt3.txt
summary:
  key: cord-331703-4hwmajt3 authors: Occhipinti, Vincenzo; Saibeni, Simone; Sampietro, Gianluca M.; Pastorelli, Luca title: Impact of COVID-19 outbreak on the management of patients with severe IBD: a domino effect date: 2020-05-12 journal: Gastroenterology DOI: 10.1053/j.gastro.2020.05.027 sha: doc_id: 331703 cord_uid: 4hwmajt3 nan The International Organization for the study of Inflammatory Bowel Diseases (IOIBD) recently published on Gastroenterology a consensus 1 about the management of IBD patients during the coronavirus disease 19 (COVID-19) pandemic, addressing several topics of interest such as the risk of infection in IBD patients, how to manage therapies and how to safely provide continuity of biological therapy. Indeed, as IBD physicians working in one of the most severely affected regions of the world (Lombardia region, in northern Italy 2 ), we had to face additional and unexpected difficulties, while managing severe IBD during the SARS-CoV-2 outbreak.


id: cord-286912-cww4ha3j
author: Manolakis, Anastassios C
date: 2017-01-21
extension: .txt
mime: text/plain
words: 5364
sentence: 222
flesch: 43
cache: cache/cord-286912-cww4ha3j.txt
txt: txt/cord-286912-cww4ha3j.txt
title:
  α2-Heremans-schmid glycoprotein (fetuin A) downregulation and its utility in inflammatory bowel disease

summary:
  AHSG levels were comparable between the CD and UC groups. Based on AHSG levels IBD patients could be distinguished from HC with about 90% sensitivity and specificity.


id: cord-303942-77nbi3ws
author: Segal, Jonathan P
title: Prevention of COVID-19 in patients with IBD
date: 2020-05-20
extension: .txt
mime: text/plain
words: 633
sentence: 22
flesch: 40
cache: cache/cord-303942-77nbi3ws.txt
txt: txt/cord-303942-77nbi3ws.txt
summary:
  BSG COVID-19 Guidance on IBD patient risk groups a systematic analysis for the Global Burden of Disease Study British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic Systematic review: thalidomide and thalidomide analogues for treatment of inflammatory bowel disease As further evidence accumulates, our understanding of COVID-19-related risks in IBD populations globally will improve.


id: cord-343832-xg3swuzs
author: Pugliese, Daniela
date: 2020-06-18
extension: .txt
mime: text/plain
words: 1744
sentence: 61
flesch: 33
cache: cache/cord-343832-xg3swuzs.txt
txt: txt/cord-343832-xg3swuzs.txt
title:
  The management of Inflammatory Bowel Diseases in the era of COVID-19 pandemic: when “non-urgent” does not mean “deferrable”

summary:
  Transition from paediatric to adult health care setting is a crucial phase for IBD patients, requiring structured programs, joint paediatric-adult clinic and an approach tailored to the patients. 8 b) IBD patients with cancer: The management of IBD patients with cancer requires a strong multidisciplinary collaboration between gastroenterologists and oncologists. Risks and benefits of introducing/maintaining IBD medical therapies should be balanced for each patient, according to IBD clinical activity and cancer diagnosis.


id: cord-323553-bukm9m9q
author: Song, Woo-Jin
date: 2019-08-31
extension: .txt
mime: text/plain
words: 4255
sentence: 155
flesch: 41
cache: cache/cord-323553-bukm9m9q.txt
txt: txt/cord-323553-bukm9m9q.txt
title:
  Canine adipose tissue-derived mesenchymal stem cells pre-treated with TNF-alpha enhance immunomodulatory effects in inflammatory bowel disease in mice

summary:
  Pharmacokinetics and clinical efficacy of cyclosporine treatment of dogs with steroid-refractory inflammatory bowel disease Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor Inflammatory bowel disease in the dog: differences and similarities with humans Immunomodulatory effects of soluble factors secreted by feline adipose tissuederived mesenchymal stem cells Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases Protein-losing enteropathies in dogs Pretreatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis Tumor necrosis factor-α-activated human adipose tissue-derived mesenchymal stem cells accelerate cutaneous wound healing through paracrine mechanisms Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells Human Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2 Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-β1 alleviate atopic dermatitis by reducing mast cell degranulation Canine adipose tissue-derived mesenchymal stem cells ameliorate severe acute pancreatitis by regulating T cells in rats Clinical trial of human umbilical cord blood-derived stem cells for the treatment of moderate-to-severe atopic dermatitis: phase I/IIa studies Mesenchymal stem cells and their therapeutic applications in inflammatory bowel disease The Commensal Bacterium Faecalibacterium prausnitzii Is Protective in DNBS-induced Chronic Moderate and Severe Colitis Models Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages Angiogenic and anti-inflammatory properties of mesenchymal stem cells from cord blood: soluble factors and extracellular vesicles for cell regeneration DNBS/TNBS Colitis Models: Mesenchymal stem cells (MSCs), which release immunomodulatory factors such as tumor necrosis factor-α (TNF-α)-induced gene/protein 6 (TSG-6) and prostaglandin E2 (PGE2), have been suggested as an alternative therapeutic option for IBD treatment in veterinary medicine.


id: cord-317151-cxx5pcln
author: Papa, Alfredo
date: 2020-10-24
extension: .txt
mime: text/plain
words: 5035
sentence: 191
flesch: 37
cache: cache/cord-317151-cxx5pcln.txt
txt: txt/cord-317151-cxx5pcln.txt
title:
  Covid-19 and the management of patients with inflammatory bowel disease: a practical decalogue for the post-pandemic phase

summary:
  Coronavirus situation report Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Evidence for gastrointestinal infection of SARS-CoV-2 Challenges in the care of IBD patients during the CoVID-19 pandemic: report from a Red Zone area in Northern Italy Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT registry Anti-TNFalpha agents in inflammatory bowel disease and course of COVID-19 Impact of COVID-19 pandemic on the daily management of biotechnological therapy in inflammatory bowel disease patients: reorganisational response in a high-volume Italian inflammatory bowel disease centre European Crohn's and Colitis Organization. A retrospective study from the United States including a large cohort of IBD patients reported that the incidence rate of COVID-19 per 1000 IBD patients was of 0.61 in patients treated with anti-TNF-α and 1 in those not in treatment with anti-TNF-α (p = 0.618).


id: cord-269835-mz7i66qp
author: Furfaro, Federica
title: SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience
date: 2020-06-11
extension: .txt
mime: text/plain
words: 7284
sentence: 223
flesch: 30
cache: cache/cord-269835-mz7i66qp.txt
txt: txt/cord-269835-mz7i66qp.txt
summary:
  ESGE and ESGENA Position Statement on Gastrointestinal Endoscopy and the COVID-19 Pandemic Implications of COVID-19 for patients with pre-existing digestive diseases Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific Society for Digestive Endoscopy (APSDE-COVID statements) COVID-19 and gastrointestinal endoscopies: current insights and emergent strategies Endoscopy in inflammatory bowel diseases during the COVID-19 pandemic and postpandemic period Coronavirus COVID-19 Global Cases Report of the WHO-China Joint Mission on Coronavirus Disease Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study Sensitivity of nasopharyngeal, nasal and throat swab for the detection of SARS-CoV-2 Respiratory virus shedding in exhaled breath and efficacy of face masks Société Française d'Endoscopie Digestive. Nat Rev Gastroenterol Hepatol DOI: 10.1038/s41575-020-0319-3 sha: doc_id: 269835 cord_uid: mz7i66qp The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has required a complete change in the management of patients with inflammatory bowel disease (IBD) who need to undergo endoscopic procedures.


id: cord-345786-1o9nx7z9
author: Bernstein, Charles N
date: 2020-08-14
extension: .txt
mime: text/plain
words: 3739
sentence: 168
flesch: 47
cache: cache/cord-345786-1o9nx7z9.txt
txt: txt/cord-345786-1o9nx7z9.txt
title:
  Worldwide Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: An International Survey

summary:
  It is unknown to what extent the responses reflect the majority of gastroenterologists managing IBD patients in each jurisdiction, especially because the respondents were leaders in IBD management in their respective countries. 3) Are you conducting any elective endoscopy in IBD patients, and if so, for which indications have you been undertaking endoscopy ( Bangladesh (n = 2)


id: cord-347607-ydbyonbg
author: Spagnuolo, Rocco
date: 2020-08-13
extension: .txt
mime: text/plain
words: 3727
sentence: 152
flesch: 43
cache: cache/cord-347607-ydbyonbg.txt
txt: txt/cord-347607-ydbyonbg.txt
title:
  COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey

summary:
  J. Crohn's Colitis 2020 Maintaining the Quality Standards of Care for Inflammatory Bowel Disease Patients During the COVID-19 Pandemic Protection of 318 Inflammatory Bowel Disease Patients from the Outbreak and Rapid Spread of COVID-19 Infection in Wuhan Uneventful course in IBD patients during SARS-CoV-2 outbreak in northern Italy IOIBD Update on COVID19 for Patients with Crohn's Disease and Ulcerative Colitis Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease DOP064 ECCO expert consensus and topical review on treatment exit strategies in inflammatory bowel disease. At date, several ongoing studies evaluate management of IBD patients during pandemic reporting as CD and UC does not increase risk of infection


id: cord-337896-mct29erg
author: Kornbluth, Asher
date: 2020-09-03
extension: .txt
mime: text/plain
words: 5119
sentence: 176
flesch: 50
cache: cache/cord-337896-mct29erg.txt
txt: txt/cord-337896-mct29erg.txt
title:
  Management of Inflammatory Bowel Disease and COVID-19 in New York City 2020: The Epicenter of IBD in the First Epicenter of the Global Pandemic

summary:
  Our extensive experience in caring for IBD patients with COVID-19 stems from our practice in which we have a very large IBD patient population of Ashkenazi Orthodox and Hasidic Jews that comprises nearly 75% of our cohort. SECURE-IBD Database Public Data Update New York Times Corona Virus Map and Cases Count COVID-19 (Coronavirus): What IBD Patients Should Know BSG) advice for management of inflammatory bowel diseases during the COVID-19 pandemic AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary IOIBD COVID-19 Webinars and Guidelines.


id: cord-322957-clf8f90t
author: Crespo, Javier
date: 2020-04-28
extension: .txt
mime: text/plain
words: 5301
sentence: 266
flesch: 46
cache: cache/cord-322957-clf8f90t.txt
txt: txt/cord-322957-clf8f90t.txt
title:
  Resumption of activity in gastroenterology departments. Recommendations by SEPD, AEEH, GETECCU and AEG

summary:
  General recommendations regarding the treatment of patients with IBD, which must remain in force during the gradual resumption of activities: a. Patients must not discontinue medication or visits to the infusion center, or start self-medication, without consulting with their doctor first. A possible reason explaining this lower number of cases of COVID-19 in IBD patients may be this population's adherence to protective measures.


id: cord-316354-pix0hmpj
author: Kennedy, Nicholas A
date: 2020-06-15
extension: .txt
mime: text/plain
words: 5237
sentence: 219
flesch: 45
cache: cache/cord-316354-pix0hmpj.txt
txt: txt/cord-316354-pix0hmpj.txt
title:
  Organisational changes and challenges for inflammatory bowel disease services in the UK during the COVID-19 pandemic

summary:
  Frontline Gastroenterol DOI: 10.1136/flgastro-2020-101520 sha: doc_id: 316354 cord_uid: pix0hmpj OBJECTIVE: To determine the challenges in diagnosis, monitoring, support provision in the management of inflammatory bowel disease (IBD) patients and explore the adaptations of IBD services. METHODS: Internet-based survey by invitation of IBD services across the UK from 8 to 14 April 2020.


id: cord-349500-603v8lfb
author: Neurath, Markus F
title: Covid-19 and immunomodulation in IBD
date: 2020-04-16
extension: .txt
mime: text/plain
words: 6564
sentence: 260
flesch: 37
cache: cache/cord-349500-603v8lfb.txt
txt: txt/cord-349500-603v8lfb.txt
summary:
  In contrast, another study reported that covid-19 ICU patients had significantly higher serum levels of TNF than non-ICU patients. Therefore, this review will address the following questions: ► What is the evidence for intestinal covid-19 disease and how does covid-19 induce mucosal immune cell activation and a cytokine release syndrome?


id: cord-023134-y665agnh
title: Oral Research Communications of the 22(nd) ECVIM‐CA Congress
date: 2012-11-20
extension: .txt
mime: text/plain
words: 29627
sentence: 1357
flesch: 47
cache: cache/cord-023134-y665agnh.txt
txt: txt/cord-023134-y665agnh.txt
summary:
  Concerning gross pathology findings in hearts with clinical DCM diagnosis, LV chambers were dilated in 3/4 cases of group 4, while in groups 3 and 5, the papillary muscles appeared grossly prominent and not flattened as in group 4.Histopathologically, in control dogs LV and RV myocardium showed no (3/4) or mild (1/4) interstitial collagen deposits, no or single adipocytes, and normal vessels. Histopathologically, RAA in control dogs showed small amounts of interstitialcollagen and single adipocytes.


id: cord-026025-xqj877en
author: PETRAS, ROBERT E.
title: Large Intestine (Colon)
date: 2009-10-30
extension: .txt
mime: text/plain
words: 48346
sentence: 2317
flesch: 37
cache: cache/cord-026025-xqj877en.txt
txt: txt/cord-026025-xqj877en.txt
summary:
  Large cell carcinoma and small cell carcinoma of the colon and rectum have a poor prognosis. A phase II trial with preliminary evidence of antiviral activity and low incidence of opportunistic infection Multicenter trial of lowdose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma Docetaxel in anthracycline-pretreated AIDS-related Kaposi's sarcoma: A retrospective study Angiosarcoma of the colon and rectum: Report of a case and review of the literature Endoscopic management of rectal Dieulafoy-like lesions: A case series and review of literature Familial Polyposis Coli The Pathogenesis of Colorectal Cancer Cribriform-morular variant of papillary carcinoma: A distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma Gastric and duodenal polyps in familial adenomatous polyposis: A prospective study of the nature and prevalence of upper gastrointestinal polyps Fundic gland polyps in familial adenomatous polyposis: Neoplasms with frequent somatic adenomatous polyposis coli gene alterations The risk of upper gastrointestinal cancer in familial adenomatous polyposis Localization of the gene for familial adenomatous polyposis on chromosome 5 The gene for familial polyposis coli maps to the long arm of chromosome 5 Identification and characterization of the familial adenomatous polyposis coli gene Identification of FAP locus genes from chromosome 5q21 Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients The multiple colorectal adenoma phenotype and MYH, a base excision repair gene Responsive colon cancer cell lines to the introduction of APC, a colon-specific tumor suppressor gene Familial adenomatous polyposis Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients Attenuated familial adenomatous polyposis (AFAP).


id: cord-014516-r59usk02
title: Research Communications of the 24th ECVIM‐CA Congress
date: 2015-01-10
extension: .txt
mime: text/plain
words: 55086
sentence: 2641
flesch: 49
cache: cache/cord-014516-r59usk02.txt
txt: txt/cord-014516-r59usk02.txt
summary:
  Method specificity was confirmed by the absence of matrix effect in six serum specimen obtained from clinical dogs. Stage C dogs had lower SRs (p = 0.0005), higher SRe (p = 0.0029) and SRa (p = 0.0004) than other dogs.


id: cord-022555-a7ie82fs
title: Digestive System, Liver, and Abdominal Cavity
date: 2011-12-05
extension: .txt
mime: text/plain
words: 66503
sentence: 3320
flesch: 46
cache: cache/cord-022555-a7ie82fs.txt
txt: txt/cord-022555-a7ie82fs.txt
summary:
  The worm is transmitted to other cats that ingest the vomitus of an infected cat. Other cats should not be allowed to ingest infected vomit.


id: cord-014527-nvzfpntu
title: Research Communications of the 25th ECVIM‐CA Congress
date: 2015-11-09
extension: .txt
mime: text/plain
words: 89290
sentence: 4308
flesch: 49
cache: cache/cord-014527-nvzfpntu.txt
txt: txt/cord-014527-nvzfpntu.txt
summary:
  Dogs in the prolonged OS group were more likely to be anaemic on presentation (PCV<37%, P = 0.041), experienced a greater FRD (P = 0.012) and were more likely to be treated with a rescue protocol (P = 0.036) than other dogs. Dogs that did not respond to treatment had significantly higher S100A12 levels than dogs with partial (P = 0.005) or complete (P = 0.003) remission, but response to treatment was associated with disease classification (P = 0.020).


id: cord-023095-4dannjjm
title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011
date: 2011-05-03
extension: .txt
mime: text/plain
words: 134382
sentence: 6200
flesch: 49
cache: cache/cord-023095-4dannjjm.txt
txt: txt/cord-023095-4dannjjm.txt
summary:
  Mminimum HR, mean HR and the HRV variables (7 and 10) differing between dog groups, also consistently decreased with increasing MR, LA/Ao and the proximal isovelocity surface area in CKCS. The apparently normal levels of hexosaminidase A activity in affected dog samples may be a result of b subunit overexpression.


id: cord-022888-dnsdg04n
title: Poster Sessions
date: 2009-08-19
extension: .txt
mime: text/plain
words: 189173
sentence: 7869
flesch: 41
cache: cache/cord-022888-dnsdg04n.txt
txt: txt/cord-022888-dnsdg04n.txt
summary:
  Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines.


# url

id: cord-275447-nx45kwn6
domain: www.fda.gov
url:
  www.fda.gov/drugs/drug-safety-and-availability/fdaadvises-patients-use-non-steroidal-anti-inflammatory-drugs-nsa


id: cord-275447-nx45kwn6
domain: www.sciencemediacentre.org
url:
  www.sciencemediacentre.org/expert-reaction-to-reportsthat-the-french-health-minister-recommended-use-of-paracetamolfor-fever-from-covid-19-rather-than-ibuprofen-or-cortisone


# ent

id: cord-306760-05my504t
sid: 143
eid: 7
type: ORG
entity:
  nanjing medical university wuhan children's hospital the children's hospital xiamen children's hospital shengjing hospital of china medical university


