item: #1 of 440 id: cord-000349-k0p166fr author: Olive, David title: Severe pneumococcal pneumonia: impact of new quinolones on prognosis date: 2011-03-15 words: 3647 flesch: 37 summary: This combination, proposed by current guidelines as empirical treatment of severe CAP patients admitted in ICU could improve their prognosis. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy In-vitro activity of levofloxacin against Streptococcus pneumoniae with various levels of penicillin resistance A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia A multicenter, open-label, randomized comparison of levofloxacin vs azithromycin plus ceftriaxone in hospitalized adults with moderate to severe communityacquired pneumonia Multicenter, open-label, randomized study to compare the safety and efficacy of levofloxacin versus ceftriaxone sodium and erythromycin followed by clarithromycin and amoxicillin-clavulanate in the treatment of serious communityacquired pneumonia in adults Caulin E, for the levofloxacin study group: Comparison of levofloxacin and cefotaxime combined with ofloxacin for ICU patients with community-acquired pneumonia who do not require vasopressors Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro In vitro interaction between ofloxacin and cefotaxime against grampositive and gram negative bacteria involved in serious infections Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia International Pneumococcal Study Group: Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia The Acute Respiratory Distress Syndrome Network: keywords: cap; group; icu; lactam; patients; pneumonia cache: cord-000349-k0p166fr.txt plain text: cord-000349-k0p166fr.txt item: #2 of 440 id: cord-000522-d498qj2b author: Vincent, Jean-Louis title: Reducing mortality in sepsis: new directions date: 2002-12-05 words: 8718 flesch: 43 summary: Interestingly, this decrease was apparent even before the five interventions discussed in the present article were published, reflecting improvements in the general supportive care of sepsis patients. Generalists have been taught to recognize the signs Sepsis patients often come 'second hand' from a and symptoms of AMI; initial treatment is usually specialist who may not be appropriately trained to provided by emergency physicians, who are trained diagnose, manage, and refer patients with sepsis to treat these patients Mortality prior to hospital discharge in patients receiving a tidal volume of 6 and 12 ml/kg ideal body weight. keywords: alfa; care; drotrecogin; group; icu; interventions; mortality; patients; protein; sepsis; shock; study; therapy; treatment; trial cache: cord-000522-d498qj2b.txt plain text: cord-000522-d498qj2b.txt item: #3 of 440 id: cord-000683-mig5zt5p author: Delgado-Rodríguez, Miguel title: Prognosis of hospitalized patients with 2009 H1N1 influenza in Spain: influence of neuraminidase inhibitors date: 2012-03-30 words: 2484 flesch: 41 summary: A total of 813 patients hospitalized with H1N1 influenza in 36 hospitals (nationwide) in Spain were analysed. Detailed histories of variables preceding hospital admission were obtained by interview, validating data on medications and vaccine with their attending physicians. keywords: h1n1; hospital; influenza; inhibitors; neuraminidase; patients cache: cord-000683-mig5zt5p.txt plain text: cord-000683-mig5zt5p.txt item: #4 of 440 id: cord-000705-w52dc97h author: Ríos, Fernando G title: Lung Function and Organ Dysfunctions in 178 Patients Requiring Mechanical Ventilation During The 2009 Influenza A (H1N1) Pandemic date: 2011-08-17 words: 4860 flesch: 43 summary: This was a multicenter, inception cohort study that included patients aged > 15 years admitted to the ICU with a previous history of influenza-like illness, evolving to acute respiratory failure that required mechanical ventilation during the 2009 winter in the Southern Hemisphere. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial Anzueto A: Tidal volume in mechanical ventilation: the importance of considering predicted body weight Pressure-and Volume-Limited Ventilation Strategy Group: Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome The Multicenter Trail Group on Tidal Volume reduction in ARDS: keywords: acute; day; h1n1; influenza; non; pandemic; patients; study; survivors; ventilation cache: cord-000705-w52dc97h.txt plain text: cord-000705-w52dc97h.txt item: #5 of 440 id: cord-000812-mu5u5bvj author: Wiesen, Jonathan title: Relative cost and outcomes in the intensive care unit of acute lung injury (ALI) due to pandemic influenza compared with other etiologies: a single-center study date: 2012-08-28 words: 4101 flesch: 40 summary: World now at the start of 2009 influenza pandemic California Pandemic (H1N1) Working Group: Severe 2009 H1N1 influenza in pregnant and postpartum women in California Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina Critical care services and H1N1 influenza in Australia and New Zealand Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome Critically Ill patients with 2009 influenza A(H1N1) in Mexico Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain Critically ill patients with 2009 influenza A(H1N1) infection in Canada Pandemic (H1N1) 2009: epidemiological, clinical and prevention aspects Hospitalized patients with 2009 H1N1 influenza in the United States Pandemic (H1N1) 2009 influenza Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza, Bautista E, Chotpitayasunondh T: Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection Clinical management of pandemic 2009 influenza A(H1N1) infection H1N1: viral pneumonia as a cause of acute respiratory distress syndrome Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus Hospitalized patients with 2009 H1N1 influenza infection: the Mayo Clinic experience Clinical findings and demographic factors associated with ICU admission in Utah due to novel 2009 influenza A(H1N1) infection The macroeconomic impact of pandemic influenza: estimates from models of the United Kingdom, France, Belgium and The Netherlands Cost-effectiveness analysis of hospital infection control response to an epidemic respiratory virus threat Economic consequences to society of pandemic H1N1 influenza 2009 -preliminary results for Sweden Effectiveness and cost-effectiveness of vaccination against pandemic influenza (H1N1) 2009 Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support Severe refractory hypoxaemia in H1N1 (2009) intensive care patients: initial experience in an Asian regional hospital Lung recruitment in patients with the acute respiratory distress syndrome Epidemiology and outcomes of acute lung injury Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome Adult respiratory distress syndrome: hospital charges and outcome according to underlying disease Variable costs of ICU patients: a multicenter prospective study Relative cost and outcomes in the intensive care unit of acute lung injury (ALI) due to pandemic influenza compared with other etiologies: a single-center study The authors declare that they have no competing interests. Compared with other studies of pandemic influenza patients who required mechanical ventilation, SOFA scores (mean 8.3) were similar, although APACHE II (25 ± 9) scores were higher [5] [6] [7] [8] 14, 16, 17, 23] . keywords: group; h1n1; icu; influenza; noninfluenza; pandemic; patients cache: cord-000812-mu5u5bvj.txt plain text: cord-000812-mu5u5bvj.txt item: #6 of 440 id: cord-000891-5r2in1gw author: Giannella, Maddalena title: Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date: 2012-06-14 words: 4120 flesch: 39 summary: Multivariate analysis showed admission to the surgical ICU (odds ratio (OR), 37.1; 95% confidence interval (CI), 2.1 to 666.6; P = 0.01) and localized infiltrate on chest radiograph (OR, 27.8; 95% CI, 1.3 to 584.1; P = 0.03) to be independent risk factors for unsuspected influenza. A logistic binary model was used to analyze the independent risk factors for unsuspected influenza and 30-day mortality. keywords: admission; cases; diagnosis; hospital; icu; influenza; pandemic; patients; samples cache: cord-000891-5r2in1gw.txt plain text: cord-000891-5r2in1gw.txt item: #7 of 440 id: cord-000892-l9862er0 author: Richard, Jean-Christophe Marie title: Interest of a simple on-line screening registry for measuring ICU burden related to an influenza pandemic date: 2012-07-09 words: 3964 flesch: 47 summary: At the same time, we recorded data corresponding to the cohort of ICU patients through a large research network on mechanical ventilation (REVA-SRLF registry) An on-line screening registry allowed a daily report of ICU beds occupancy rate by flu infected patients (Flu-OR) admitted in French ICUs. keywords: flu; icu; icus; influenza; pandemic; patients; registry; study; university cache: cord-000892-l9862er0.txt plain text: cord-000892-l9862er0.txt item: #8 of 440 id: cord-001322-7xmxcm35 author: Walden, Andrew P title: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort date: 2014-04-01 words: 4294 flesch: 41 summary: In one study, the death rate of ICU patients between 28 days and 6 months was 9% in patients with sepsis, similar to the 8% seen in ICU patients without sepsis [36] and the 10% found in the present study. This compares to an increase in mortality from 18.2% at 30 days to 24.8% at 90 days in the subgroup of ICU patients in the PORT study [24] and an increase from 17.3% to 34.8% at 12 months in the GenIMS cohort of ICU patients [3] . keywords: cap; community; icu; mortality; outcome; patients; pneumonia; severe; study cache: cord-001322-7xmxcm35.txt plain text: cord-001322-7xmxcm35.txt item: #9 of 440 id: cord-001536-ta1i0ata author: Nair, Girish B title: Year in review 2013: critical care - respiratory infections date: 2014-10-29 words: 8910 flesch: 34 summary: In another study, including 350 patients, investigators using data from electronic medical records compared the incidence and outcomes in VAP patients using various definitions, including the new CDC ventilator-associated event algorithm, before and after a VAP bundle was introduced in their institution (pre-bundle period January 2003 to December 2006 (n = 213); post-bundle period January 2007 to December 2009 (n = 137)) As with the previous study, VAP patients with susceptible PA received adequate empiric antibiotic coverage more often, both empiric and definitive, than patients with MDR pathogens (68% versus 30%, P <0.001). keywords: antibiotic; icu; infection; mortality; pathogens; patients; pneumonia; risk; sepsis; study; therapy; vap; ventilator cache: cord-001536-ta1i0ata.txt plain text: cord-001536-ta1i0ata.txt item: #10 of 440 id: cord-001725-pw7coi3v author: Ballus, Josep title: Surgical site infection in critically ill patients with secondary and tertiary peritonitis: epidemiology, microbiology and influence in outcomes date: 2015-07-30 words: 3443 flesch: 40 summary: The epidemiology of intra-abdominal flora in critically ill patients with secondary and tertiary abdominal sepsis Intensive care unit management of intra-abdominal infection Risk factors for severe sepsis in secondary peritonitis Surgical infections in the critically ill Risk factors for wound infection after surgery for colorectal cancer CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections Surgical wound infection: epidemiology, pathogenesis, diagnosis and Management APACHE II: a severity of disease classification system Implications of 2,457 consecutive surgical infections entering year 2000 Adverse impact of surgical site infections in English hospitals National nosocomial infections surveillance system (NNIS): description of surveillance methods Microbiological diagnosis of intra-abdominal infections Overview of the etiology of wound infections with particular emphasis on community-acquired illnesses A risk factor analysis of healthcare-associated fungal infections in an intensive care unit: a retrospective cohort study Fungal infections in ICU patients: epidemiology and the role of diagnostics Continuous, 10-year wound infection surveillance: results, advantages, and unanswered questions The authors wish to thank the ICU nurses and all members of the general surgery department for their contribution to the study and for their care of the patients reported in this paper. However, we concede that TPN is a risk factor for all types of fungal infection in ICU, especially among surgical patients [20] . keywords: hospital; icu; infection; patients; peritonitis; ssi; surgery cache: cord-001725-pw7coi3v.txt plain text: cord-001725-pw7coi3v.txt item: #11 of 440 id: cord-001938-n2d5fw2f author: Ong, David S. Y. title: Cytomegalovirus reactivation and mortality in patients with acute respiratory distress syndrome date: 2016-03-01 words: 4487 flesch: 32 summary: CMV reactivation CMV reactivation occurred in 74 (27 %) of the included patients (Table 1 ). We aimed to estimate the attributable effect of CMV reactivation on mortality in immunocompetent ARDS patients. keywords: ards; cmv; disease; icu; mortality; patients; reactivation; study; time cache: cord-001938-n2d5fw2f.txt plain text: cord-001938-n2d5fw2f.txt item: #12 of 440 id: cord-002011-u6dfp6gf author: Toubiana, Julie title: Association of REL polymorphisms and outcome of patients with septic shock date: 2016-04-08 words: 3960 flesch: 44 summary: The present study showed that septic shock patients carrying the rs842647*G minor allele had an over risk of MODS and mortality. This study was the first to investigate the importance of two polymorphisms within REL gene in a large European population of septic shock patients. keywords: association; crel; group; icu; mortality; patients; rel; sepsis; shock; study cache: cord-002011-u6dfp6gf.txt plain text: cord-002011-u6dfp6gf.txt item: #13 of 440 id: cord-002847-w3r0oetd author: Kanafani, Zeina A. title: Multi-drug resistant Acinetobacter species: a seven-year experience from a tertiary care center in Lebanon date: 2018-01-22 words: 3908 flesch: 44 summary: The total number of patients with Acinetobacter infections diagnosed between 2007 and 2014 was 128 (Table 3 ). on dry surfaces Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization Criteria for patient admission to an intensive care unit and related mortality rates Healthcare Infection Control Practices Advisory C. Management of multidrug-resistant organisms in health care settings Surveillance of antimicrobial resistance in Lebanese hospitals: retrospective nationwide compiled data Heterogeneity of Carbapenem resistance mechanisms among gram-negative pathogens in Lebanon: results of the first cross-sectional countrywide study Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance National Healthcare Safety Network report, data summary for 2013, device-associated module National healthcare safety network (NHSN) report, data summary for Colistin susceptibility testing by Etest and disk diffusion methods Evaluation of the Etest method for detecting colistin susceptibility of multidrug-resistant gramnegative isolates in Vietnam Multidrug-resistant Acinetobacter baumannii Concurrent outbreak of multidrugresistant and susceptible subclones of Acinetobacter Baumannii affecting different wards of a single hospital Nosocomial imipenem-resistant Acinetobacter Baumannii infections: epidemiology and risk factors Carbapenem-resistant Acinetobacter Baumannii in intensive care unit patients: risk factors for acquisition, infection and their consequences Multidrug resistant Acinetobacter Baumannii: risk factors for appearance of imipenem resistant strains on patients formerly with susceptible strains A reflection on bacterial resistance to antimicrobial agents at a major tertiary care center in Lebanon over a decade Acinetobacter spp. keywords: acinetobacter; care; control; icu; infections; mdr; patients; study cache: cord-002847-w3r0oetd.txt plain text: cord-002847-w3r0oetd.txt item: #14 of 440 id: cord-003085-7krf1yxz author: Li, Xi title: Cytomegalovirus infection and outcome in immunocompetent patients in the intensive care unit: a systematic review and meta-analysis date: 2018-06-28 words: 3797 flesch: 37 summary: However, whether CMV infection or CMV reactivation contributes to mortality of immunocompetent patients remains unclear. For CMV seropositive patients, the OR for mortality in patients with CMV reactivation as compared with patients without CMV reactivation was 1.72 (95%CI 1.04–2.85, I(2) = 29%, n = 664). keywords: cmv; cytomegalovirus; infection; mortality; patients; reactivation; studies cache: cord-003085-7krf1yxz.txt plain text: cord-003085-7krf1yxz.txt item: #15 of 440 id: cord-003198-1kw5v6rm author: Vuillard, Constance title: Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study date: 2018-09-11 words: 4860 flesch: 36 summary: 22 Service de Réanimation médicale Unité de Réanimation et de Surveillance continue, Service de Pneumologie et Réanimation médicale, Groupe hospitalier Pitié-Salpêtrière, 47-83 bd de l'hôpital A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients Do we need ARDS? Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study Acute respiratory distress syndrome: the Berlin definition Diagnostic workup for ARDS patients Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset Dermato-pulmonary syndrome associated with MDA-5 antibodies A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature. Antisynthetase syndrome Clinical and serological aspects of patients with anti-Jo-1 antibodies-an evolving spectrum of disease manifestations Myositis specific autoantibodies: changing insights in pathophysiology and clinical associations Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis Comparison of long-term outcome between anti-Jo1-and anti-PL7/PL12 positive patients with antisynthetase syndrome The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study Clinical features and outcomes of interstitial lung disease in anti-Jo-1 positive antisynthetase syndrome Acute respiratory failure in critically ill patients with interstitial lung disease Idiopathic pulmonary fibrosis: predicting response to therapy and survival Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy The role of open-lung biopsy in ARDS keywords: acute; amda-5; anti; dermato; icu; lung; patients; pulmonary; syndrome cache: cord-003198-1kw5v6rm.txt plain text: cord-003198-1kw5v6rm.txt item: #16 of 440 id: cord-003376-2qi4aibx author: van de Groep, Kirsten title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date: 2018-12-18 words: 3893 flesch: 38 summary: Patients with CMV reactivation had a more pronounced increase of IP-10 (median percentage difference of 44% versus −15%) and decrease of IL-1RA (median percentage difference of −41% versus 0%) on day 7 after viremia onset compared with CMV seropositive patients without reactivation. Based on previous studies in ICU patients, there is a clear pathophysiological link between inflammation and immune suppression on the one hand and the subsequent risk of CMV reactivation on the other keywords: biomarkers; cmv; comparison; cytomegalovirus; icu; patients; reactivation; study; time cache: cord-003376-2qi4aibx.txt plain text: cord-003376-2qi4aibx.txt item: #17 of 440 id: cord-003532-lcgeingz author: None title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: 80115 flesch: 48 summary: Blood cultures were sent as per clinical & laboratory diagnosis of sepsis in ICU patients. Conclusions: HR, lactate levels and age before AVP initiation can predict the response to AVP in ICU patients with NE-resistant hypotension. keywords: acute; admission; age; aim; aki; analysis; arrest; arterial; assessment; baseline; blood; cardiac; care; care unit; cases; clinical; complications; conclusions; correlation; critical; data; days; diagnosis; difference; discharge; ecmo; effect; emergency; factors; failure; fig; figure; fluid; group; high; hospital; hospital mortality; hours; icu; icu admission; icu patients; ill; incidence; increase; injury; intensive; intervention; introduction; lactate; length; levels; low; lung; management; map; mean; median; medical; methods; months; mortality; non; organ; outcome; patients; patients introduction; period; post; pressure; rate; ratio; response; results; resuscitation; risk; score; sepsis; sepsis patients; septic; serum; severity; shock patients; sofa; stay; studies; study; surgery; survival; system; table; test; therapy; time; total; trauma; treatment; ultrasound; unit; use; ventilation; years cache: cord-003532-lcgeingz.txt plain text: cord-003532-lcgeingz.txt item: #18 of 440 id: cord-003701-i70ztypg author: Chow, Eric J. title: Influenza virus-related critical illness: prevention, diagnosis, treatment date: 2019-06-12 words: 6873 flesch: 16 summary: • Enterically administered oseltamivir is recommended for influenza patients except for those with contraindications (e.g., gastric stasis, ileus, malabsorption). In particular, a large pooled individual patient-level meta-analysis of observational studies from 38 countries identified a 38% reduction in risk of mortality in critically ill adults and those aged ≥ 16 years old when comparing early NAI treatment (< 48 h) with later treatment (> 48 h), and a 69% reduction in mortality risk between influenza patients receiving early NAI treatment and those who did not receive NAIs [72] . keywords: adults; infection; influenza; mortality; oseltamivir; patients; risk; studies; study; treatment; virus cache: cord-003701-i70ztypg.txt plain text: cord-003701-i70ztypg.txt item: #19 of 440 id: cord-003798-nki2sasr author: Vidaur, Loreto title: Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis date: 2019-07-24 words: 3506 flesch: 37 summary: In a large prospective study of ICU patients requiring invasive mechanical ventilation, hMPV was more frequently detected in patients admitted by severe respiratory infection than in patients with other causes, suggesting a causal role of HMPV in the development of severe respiratory infection [24] . Bacterial pneumonia Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: a CHAID decision-tree analysis Effect of procalcitonin guided guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the Pro-HOSP randomized controlled trial Procalcitonin guidance of antibiotic therapy in community acquired pneumonia: a randomized trial Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases The role of human Metapneumovirus genetic diversity and nasopharyngeal load on symptom severity in adults LV made substantial contribution to the conception and design of the work, the acquisition, analysis and interpretation of the data and has drafted the work. keywords: hmpv; human; icu; infection; metapneumovirus; patients; pneumonia; study cache: cord-003798-nki2sasr.txt plain text: cord-003798-nki2sasr.txt item: #20 of 440 id: cord-003832-q1422ydi author: Koyama, Kansuke title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date: 2019-08-19 words: 4663 flesch: 34 summary: A secondary analysis of the LUNG SAFE study confirmed that 8.3% of ARDS patients had no common risk factors that were identified when ARDS was recognized [6] . Thrombin-antithrombin complex (TAT) levels are increased in ARDS patients, reflecting tissue factor-and contact phase-mediated activation of coagulation cascade and excessive thrombin generation. keywords: acute; ards; biomarkers; factors; injury; lung; patients; pneumonia; respiratory; risk; study cache: cord-003832-q1422ydi.txt plain text: cord-003832-q1422ydi.txt item: #21 of 440 id: cord-004031-sw60qbbj author: Aylward, Ryan E. title: Risk factors and outcomes of acute kidney injury in South African critically ill adults: a prospective cohort study date: 2019-12-10 words: 4297 flesch: 50 summary: Although ICU length of stay was less in HIV patients with AKI (median ICU days 3 vs 6, p = 0.002), the proportion of patients with HIV who died within the first 24 h was higher at 10.5% compared to 2.6% in those who were HIV negative, p = 0.009. HIV positive patients that developed AKI were receiving Tenofovir-based HAART at the time of ICU admission. keywords: acute; aki; associated; hiv; icu; injury; kidney; mortality; patients cache: cord-004031-sw60qbbj.txt plain text: cord-004031-sw60qbbj.txt item: #22 of 440 id: cord-004096-obrq7q57 author: Benghanem, Sarah title: Brainstem dysfunction in critically ill patients date: 2020-01-06 words: 5812 flesch: 31 summary: Opioids might also contribute to brainstem dysfunction, as they depress the ARAS, respiratory centers, and brainstem reflexes (notably pupillary light and cough reflexes). key: cord-004096-obrq7q57 authors: Benghanem, Sarah; Mazeraud, Aurélien; Azabou, Eric; Chhor, Vibol; Shinotsuka, Cassia Righy; Claassen, Jan; Rohaut, Benjamin; Sharshar, Tarek title: Brainstem dysfunction in critically ill patients date: 2020-01-06 journal: Crit Care DOI: 10.1186/s13054-019-2718-9 sha: doc_id: 4096 cord_uid: obrq7q57 The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. keywords: brainstem; consciousness; dysfunction; illness; impairment; inflammatory; lesions; mortality; motor; nerve; nuclei; patients; reflexes; table cache: cord-004096-obrq7q57.txt plain text: cord-004096-obrq7q57.txt item: #23 of 440 id: cord-004147-9bcq3jnm author: Fernando, Shannon M. title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study date: 2020-01-13 words: 4163 flesch: 41 summary: We determined patient costs using the case-costing system of the Ottawa Hospital Data Warehouse, as done previously [17, 23, 27] . Finally, comparisons of patient costs between patients with and without NOAF are shown in Table 5 Table S6 ). keywords: costs; data; hospital; icu; mortality; noaf; patients; sepsis cache: cord-004147-9bcq3jnm.txt plain text: cord-004147-9bcq3jnm.txt item: #24 of 440 id: cord-004168-rqd9b13s author: Daneman, Nick title: A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards date: 2020-01-15 words: 4773 flesch: 38 summary: On the one hand, merging non-ICU patients with ICU patients into a single trial could be viewed as mixing two heterogeneous populations together. For these calculations we estimated the 90day mortality for ward patients using outcome data from this ward pilot RCT, and we estimated the mortality for ICU patients from up-to-date data from the ongoing BALANCE main RCT. keywords: balance; hospital; icu; non; patients; pilot; rct; treatment; trial; ward cache: cord-004168-rqd9b13s.txt plain text: cord-004168-rqd9b13s.txt item: #25 of 440 id: cord-004263-m1ujhhsc author: Koekkoek, W. A. C. title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study date: 2020-02-03 words: 3157 flesch: 40 summary: A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. However, this hypothesis has not been studied in ICU patients with the previously described indications for the use of continuous NMBA infusion. keywords: cisatracurium; infusion; kcal; patients; study cache: cord-004263-m1ujhhsc.txt plain text: cord-004263-m1ujhhsc.txt item: #26 of 440 id: cord-004268-raayrjmd author: Flattres, Aurelien title: Real-time shear wave ultrasound elastography: a new tool for the evaluation of diaphragm and limb muscle stiffness in critically ill patients date: 2020-02-03 words: 4598 flesch: 40 summary: Few others have assessed inter-operator and intra-operator reliability in measuring muscle shear modulus and have reported similar results. Impact of inspiratory effort Mechanical ventilation and diaphragmatic atrophy in critically ill patients: an ultrasound study The course of diaphragm atrophy in ventilated patients assessed with ultrasound: a longitudinal cohort study Skeletal muscle ultrasound in critical care: a tool in need of translation Shear wave sonoelastography of skeletal muscle: basic principles, biomechanical concepts, clinical applications, and future perspectives Noninvasive assessment of muscle stiffness in patients with Duchenne muscular dystrophy Shear wave elastography is a reliable and repeatable method for measuring the elastic modulus of the rectus femoris muscle and patellar tendon: shear wave elastography of the rectus femoris muscle and patellar tendon Ultrasound shear wave velocity in skeletal muscle: a reproducibility study Ultrasound shear wave elastography in assessment of muscle stiffness in patients with Parkinson's disease: a primary observation Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans Diaphragm muscle fiber weakness and ubiquitinproteasome activation in critically ill patients Critical illness-associated diaphragm weakness Diaphragmatic myotrauma: a mediator of prolonged ventilation and poor patient outcomes in acute respiratory failure Diaphragmatic shear modulus at various submaximal inspiratory mouth pressure levels The effect of unit, depth, and probe load on the reliability of muscle shear wave elastography: variables affecting reliability of SWE Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations We would like to thank Claudine Gniadek, RN, and the members of the medical and nursing team for their participation in the present study. keywords: diaphragm; intra; modulus; muscle; operator; patients; reliability; shear; study; swe; wave cache: cord-004268-raayrjmd.txt plain text: cord-004268-raayrjmd.txt item: #27 of 440 id: cord-004284-2prli5s1 author: Vahedian-Azimi, Amir title: Natural versus artificial light exposure on delirium incidence in ARDS patients date: 2020-02-05 words: 776 flesch: 34 summary: key: cord-004284-2prli5s1 authors: Vahedian-Azimi, Amir; Bashar, Farshid R.; Khan, Abbas M.; Miller, Andrew C. title: Natural versus artificial light exposure on delirium incidence in ARDS patients date: 2020-02-05 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0630-8 sha: doc_id: 4284 cord_uid: 2prli5s1 nan We read with interest the study by Smonig et al. No difference in delirium incidence or duration, MV duration, self-extubation, ICU or hospital length-of-stay (LOS), or mortality was observed [1] . keywords: delirium; icu; patients cache: cord-004284-2prli5s1.txt plain text: cord-004284-2prli5s1.txt item: #28 of 440 id: cord-004404-s6udpwxq author: Seifi, Najmeh title: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date: 2020-02-24 words: 4643 flesch: 37 summary: key: cord-004404-s6udpwxq authors: Seifi, Najmeh; Safarian, Mohammad; Nematy, Mohsen; Rezvani, Reza; Khadem-Rezaian, Majid; Sedaghat, Alireza title: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date: 2020-02-24 journal: Trials DOI: 10.1186/s13063-020-4136-3 sha: doc_id: 4404 cord_uid: s6udpwxq BACKGROUND: An extreme and persistent dysbiosis occurs among critically ill patients, regardless of the heterogeneity of disease. Gut microbiota in health and disease Current understanding of the human microbiome The role of the microbiome in human health and disease: an introduction for clinicians The impact of probiotics' administration on glycemic control, body composition, gut microbiome, mitochondria, and other hormonal signals in adolescents with prediabetesa randomized, controlled trial study protocol Gut microbiota: an integral moderator in health and disease Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away Muscle wasting: the gut microbiota as a new therapeutic target? Gut barrier dysfunction and microbial translocation in cancer cachexia: a new therapeutic target Malnutrition in critically ill patients in intensive care units Association between malnutrition and clinical outcomes in the intensive care unit: a systematic review Association between malnutrition and 28-day mortality and intensive care length-ofstay in the critically ill: a prospective cohort study Diagnostic criteria for malnutrition-an ESPEN consensus statement Gut microbiota, nutrient sensing and energy balance Gut microbiota and energy balance: role in obesity Use of standard enteral formula versus enteric formula with prebiotic content in nutrition therapy: a randomized controlled study among neuro-critical care patients Microbial cell preparation in enteral feeding in critically ill patients: a randomized, doubleblind, placebo-controlled clinical trial Effect of a multispecies probiotic on inflammatory markers in critically ill patients: a randomized, double-blind, placebocontrolled trial Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis The immune system bridges the gut microbiota with systemic energy homeostasis: focus on TLRs, mucosal barrier, and SCFAs Muscle loss: the new malnutrition challenge in clinical practice Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model Non digestible oligosaccharides modulate the gut microbiota to control the development of leukemia and associated cachexia in mice Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia Beneficial bacteria inhibit cachexia ESPEN guideline on clinical nutrition in the intensive care unit Effectiveness of continuous enteral nutrition versus intermittent enteral nutrition in intensive care patients: a systematic review Intermittent versus continuous feeding in critically ill adults Treatment of opioid-induced gut dysfunction Bacterial translocation: overview of mechanisms and clinical impact Gastric acid reduction leads to an alteration in lower intestinal microflora Probiotics in the critical care unit: fad, fact, or fiction? keywords: care; critical; energy; gut; homeostasis; icu; microbiota; muscle; nutrition; patients; protein; study; wasting cache: cord-004404-s6udpwxq.txt plain text: cord-004404-s6udpwxq.txt item: #29 of 440 id: cord-004422-oep1grwq author: Li, Yuting title: Comparison of T-piece and pressure support ventilation as spontaneous breathing trials in critically ill patients: a systematic review and meta-analysis date: 2020-02-26 words: 3263 flesch: 44 summary: The analysis of secondary outcomes also shows no significant difference in the rate of reintubation, ICU and hospital length of stay, and ICU and Managing the apparent and hidden difficulties of weaning from mechanical ventilation Extubation failure after successful spontaneous breathing trial: prediction is still a challenge! key: cord-004422-oep1grwq authors: Li, Yuting; Li, Hongxiang; Zhang, Dong title: Comparison of T-piece and pressure support ventilation as spontaneous breathing trials in critically ill patients: a systematic review and meta-analysis date: 2020-02-26 journal: Crit Care DOI: 10.1186/s13054-020-2764-3 sha: doc_id: 4422 cord_uid: oep1grwq BACKGROUND: keywords: extubation; patients; piece; rate; ventilation cache: cord-004422-oep1grwq.txt plain text: cord-004422-oep1grwq.txt item: #30 of 440 id: cord-004427-dy9v9asg author: Bissell, Brittany D. title: Impact of protocolized diuresis for de-resuscitation in the intensive care unit date: 2020-02-28 words: 4712 flesch: 33 summary: The overall management of patients outside of diuresis protocol was left to physician discretion. Supplementary Digital Content This file includes relevant study protocols, definitions, as well as subgroup analyses and additional informational tables beyond manuscript content. keywords: balance; days; diuresis; fluid; group; icu; intervention; patients; protocol; study cache: cord-004427-dy9v9asg.txt plain text: cord-004427-dy9v9asg.txt item: #31 of 440 id: cord-004450-daxz9yhp author: Haeberle, Helene title: Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study date: 2020-03-04 words: 5858 flesch: 36 summary: X a X a X a X a X a X a X a Fluid balance X a X a X a X a X a X a X a Transfusion of red blood cells X X X X X X X b X X X Transfusion of thrombocytes X X X X X X X b X X X Anticoagulation Infection X X X X X X X b X X X Anti-infective therapy X X X X X X X b X X X When possible, however, the patient or his legal representative is to be informed both in writing and verbally by the investigator before any study-specific procedure is Iloprost or NaCl 0.9% (control) X X X X X Clinical assessment including outcome X X X X X X X X X Laboratory testing X X X X X X X X Adverse/serious adverse event monitoring X X X X X X X Plasma biomarkers X X X X X X Barthel Index X X X X SOFA score keywords: acute; ards; day; effect; iloprost; injury; lung; patients; pulmonary; study; treatment; trial; ventilation cache: cord-004450-daxz9yhp.txt plain text: cord-004450-daxz9yhp.txt item: #32 of 440 id: cord-004487-hrkj2y8o author: Villa, Gianluca title: Validation of END-of-life ScorING-system to identify the dying patient: a prospective analysis date: 2020-03-09 words: 3747 flesch: 43 summary: Minerva Anestesiol Family Care rituals in the ICU to reduce symptoms of post-traumatic stress disorder in family members-a multicenter, multinational, before-and-after intervention trial Implementing primary palliative care best practices in critical care with the Care and Communication Bundle Organ dysfunction scores in ICU End-of-life decision making in the intensive care unit A practical tool to identify patients who may benefit from a palliative approach: the CARING criteria Medical futility: predicting outcome of intensive care unit patients by nurses and doctors--a prospective comparative study Development of END-oflife ScorING-system to identify critically ill patients after initial critical care who are highly likely to die: a pilot study Instruments for the identification of patients in need of palliative care: a systematic review protocol of measurement properties Physicians ' perceptions of the value of prognostic models : the benefits and risks of prognostic confidence Effect of a quality-improvement intervention on end-of-life care in the intensive care unit: a randomized trial Meeting standards of high-quality intensive care unit palliative care: clinical performance and predictors Developing guidelines that identify patients who would benefit from palliative care services in the surgical intensive care unit End-of-Life Practices in European. The aim of this observational study is to prospectively validate ENDING-S in a cohort of critical care patients with an ICU length of stay longer than 4 days. keywords: care; ending; icu; life; palliative; patients; stay; study cache: cord-004487-hrkj2y8o.txt plain text: cord-004487-hrkj2y8o.txt item: #33 of 440 id: cord-004515-x22q1f21 author: Pottecher, Julien title: Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients date: 2020-03-18 words: 6820 flesch: 38 summary: The primary trial objective is to demonstrate a reduction in the incidence of moderate-to-severe hypoxaemia in severe trauma patients during the first 7 days from 45% to 30% by providing aerosolized dornase alfa as compared to placebo. This treatment may facilitate ventilator weaning, reduce the burden of trauma-induced lung inflammation and facilitate recovery and rehabilitation in severe trauma patients. keywords: alfa; analysis; blood; data; day; days; dna; dornase; hypoxaemia; incidence; injury; lung; patients; study; trauma; trial; variables cache: cord-004515-x22q1f21.txt plain text: cord-004515-x22q1f21.txt item: #34 of 440 id: cord-004532-flo9139j author: Andrews, Peter title: Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis date: 2004-12-18 words: 9265 flesch: 40 summary: Last, intrahospital transport poses an important risk to ICU patients. Periextubation pain has received little attention in ICU patients. keywords: acute; authors; care; colonization; failure; icu; infection; intensive; lung; mortality; patients; study; vap; weaning cache: cord-004532-flo9139j.txt plain text: cord-004532-flo9139j.txt item: #35 of 440 id: cord-004540-2b1vjhgn author: Hick, John L. title: Chapter 2. Surge capacity and infrastructure considerations for mass critical care date: 2010-03-07 words: 4948 flesch: 32 summary: Agency for Healthcare Research and Quality Federal Emergency Management Agency-Department of Homeland Security Medical surge capacity and capability: a management system for integrating medical and health resources during large-scale emergencies Augmentation of hospital critical care capacity after bioterrorist attacks or epidemics: recommendations of the Working Group on Emergency Mass Critical Care Task Force for Mass Critical Care. Definitive care for the critically ill during a disaster: a framework for optimizing critical care surge capacity: from a Task Force for Mass Critical Care summit meeting Surge capacity concepts for health care facilities: the CO-S-TR model for initial incident assessment Refining surge capacity: conventional, contingency, and crisis capacity Providing mass medical care with scarce resources: a community planning guide. keywords: areas; beds; capacity; care; critical; emergency; hospital; icu; patient; resources; surge; units cache: cord-004540-2b1vjhgn.txt plain text: cord-004540-2b1vjhgn.txt item: #36 of 440 id: cord-004646-zhessjqh author: Bawazeer, Mohammed title: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial date: 2020-03-20 words: 7844 flesch: 38 summary: A concern was raised about the under-dosing of ketamine compared to ICU ketamine studies. This trial is a prospective, randomized, active controlled, open-label, pilot, feasibility study of adult ICU patients (> 14 years old) on MV. keywords: analysis; care; data; delirium; dose; icu; infusion; ketamine; patients; protocol; randomization; sedation; study; trial cache: cord-004646-zhessjqh.txt plain text: cord-004646-zhessjqh.txt item: #37 of 440 id: cord-005496-cnwg4dnn author: Gutierrez, Guillermo title: Artificial Intelligence in the Intensive Care Unit date: 2020-03-24 words: 5014 flesch: 38 summary: For those wishing to delve deeper into the development of machine learning models, a good source of information is the book by Müller and Guido Machine learning models have also been proposed to predict mortality in trauma [25] and pediatric ICU patients keywords: algorithm; care; data; icu; information; learning; machine; model; patients; variables cache: cord-005496-cnwg4dnn.txt plain text: cord-005496-cnwg4dnn.txt item: #38 of 440 id: cord-005497-w81ysjf9 author: None title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103795 flesch: 50 summary: Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients. keywords: acute; administration; admission; adult patients; age; aim; aki; aki patients; analysis; approach; arrest; arterial; associated; association; average; baseline; blood; cardiac; care; care patients; care unit; cases; clinical; cohort; cohort study; complications; control; critical; critical care; data; day mortality; days; death; delirium; difference; discharge; disease; early; ecmo; effect; emergency; factors; failure; figure; fluid; function; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; ill; incidence; increase; index; infection; injury; intensive; introduction; length; levels; low; lps; lung; management; mean; median; medical; methods; min; model; months; mortality; non; number; observational; organ; outcome; pain; parameters; patients; period; plasma; population; positive; post; pressure; rate; renal; results; risk; score; sepsis; sepsis patients; septic; serum; shock; shock patients; sofa; stay; studies; study; support; surgery; survival; table; test; therapy; time; total; treatment; unit; university; use; value; ventilation; volume; years cache: cord-005497-w81ysjf9.txt plain text: cord-005497-w81ysjf9.txt item: #39 of 440 id: cord-005503-hm8tvkt3 author: Rasulo, Frank A. title: Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient date: 2020-03-24 words: 5991 flesch: 31 summary: Pupil examination: validity and clinical utility of an automated pupillometer Reliability of standard pupillometry practice in neurocritical care: An observational, double-blinded study Pupillometric analysis of the 'absent light reflex Neurological prognostication of outcome in patients in coma after cardiac arrest Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series Quantitative pupillometry and neuronspecific enolase independently predict return of spontaneous circulation following cardiogenic out-of-hospital cardiac arrest: a prospective pilot study Quantitative versus standard pupillary light reflex for early prognostication in comatose cardiac arrest patients: an international prospective multicentre double-blinded study Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study Infrared pupillometry during uncal herniation Prognosis and clinical relevance of anisocoria-craniotomy latency for epidural hematoma in comatose patients Use of admission Glasgow Coma Score, pupil size, and pupil reactivity to determine outcome for trauma patients Effects of osmotic therapy on pupil reactivity: quantification using pupillometry in critically ill neurologic patients Optical pupillometry in traumatic brain injury: neurological pupil index and its relationship with intracranial pressure through significant event analysis Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury Automated pupillometry to detect command following in neurological patients: a proof-of-concept study Pupillary reflex measurement predicts insufficient analgesia before endotracheal suctioning in critically ill patients Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables Pupillary dilation reflex and pupillary pain index evaluation during general anaesthesia: a pilot study Pupillometry-guided intraoperative remifentanil administration versus standard practice influences opioid use: a randomized study Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries Transcranial color-coded duplex sonography fir bedside monitoring of central nervous system infection as a consequence of decompressive craniectomy after traumatic brain injury Non-invasive intracranial pressure assessment in brain injured patients using ultrasound-based methods Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study Transcranial Doppler Pulsatility in vasodilation and stenosis Consensus summary statement of the international multidisciplinary consensus conference on multimodality monitoring in neurocritical care Cerebral vasospasm after subarachnoid hemorrhage investigated by means of transcranial Doppler ultrasound Basilar vasospasm diagnosis: investigation of a modified Lindegaard Index based on imaging studies and blood velocity measurements of the basilar artery Transcranial color-coded duplex sonography for evaluation of midline-shift after chronic-subdural hematoma evacuation (TEMASE): A prospective study Accuracy of Power mode transcranial Doppler in the diagnosis of brain death Standardized care versus precision medicine in the perioperative setting: Can point-of-care testing help bridge the gap? A primer for EEG signal processing in anesthesia Electroencephalography and brain oxygenation monitoring in the perioperative period Beyond its use for sedative titration purposes, processed EEG may have some additional applications in ICU patients, including identification of subclinical/ unrecognized seizures or seizures occurring when neuromuscular blocking agents are administered. keywords: brain; eeg; fig; flow; icp; icu; light; monitoring; patients; pupillary; pupillometry; reflex; sedation; transcranial cache: cord-005503-hm8tvkt3.txt plain text: cord-005503-hm8tvkt3.txt item: #40 of 440 id: cord-005569-9d51l6bn author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date: 2008-12-09 words: 10277 flesch: 36 summary: Entropy of the frontal EEG does not discriminate sedation state adequately for clinical use in ICU patients. The cumulated energy deficit in ICU patients primarily on enteral nutrition, which has been reported in several studies, is mainly related to underfeeding during the initial week of ICU stay. keywords: acute; authors; care; control; delirium; glucose; icp; icu; infection; intensive; levels; monitoring; mortality; non; outcome; patients; sepsis; shock; study; therapy cache: cord-005569-9d51l6bn.txt plain text: cord-005569-9d51l6bn.txt item: #41 of 440 id: cord-005585-lc3fqhb0 author: Barbier, François title: Etiologies and outcome of acute respiratory failure in HIV-infected patients date: 2009-07-03 words: 4240 flesch: 40 summary: Pulmonary Complications of HIV infection Study Group Predictors of shortand long-term survival in HIV-infected patients admitted to the ICU Impact of HAART advent on admission patterns and survival in HIVinfected patients admitted to an intensive care unit Intensive care in patients with HIV infection in the era of highly active antiretroviral therapy Intensive care of patients with the acquired immunodeficiency syndrome: outcome and changing patterns of utilization Reappraisal of the aetiology and prognostic factors of severe acute respiratory failure in HIV patients Outcomes of intensive care for patients with human immunodeficiency virus infection Clinical course, prognostic factors, and outcome prediction for HIV patients in the ICU. Patients on ART were more likely to be admitted for bacterial pneumonia or noninfectious pulmonary disease than other patients (P = 0.02). keywords: arf; art; hiv; icu; patients; pcp; pneumonia cache: cord-005585-lc3fqhb0.txt plain text: cord-005585-lc3fqhb0.txt item: #42 of 440 id: cord-005589-ocnce92z author: Torres, Antoni title: Challenges in severe community-acquired pneumonia: a point-of-view review date: 2019-01-31 words: 6062 flesch: 32 summary: Zanamivir can be used in cases of treatment failure and/or confirmed oseltamivir resistance We recommend a combination of a beta-lactam/beta-lactamase inhibitor or a third G cephalosporin plus a macrolide in most SCAP patients Patients with SCAP and septic shock should be managed with current practice guidelines. Only one allowed enrollment of mechanically ventilated patients, while the rest specifically excluded SCAP patients [51] . keywords: antibiotic; community; icu; influenza; pathogens; patients; pneumonia; risk; scap; study; therapy; treatment cache: cord-005589-ocnce92z.txt plain text: cord-005589-ocnce92z.txt item: #43 of 440 id: cord-005600-gsbbjb5y author: De Jonghe, B. title: Acquired neuromuscular disorders in critically ill patients: a systematic review date: 1998 words: 3832 flesch: 33 summary: The first two types of drugs have been been frequently associated with the occurrence of CINMA in ICU patients with acute asthma or ARDS. Early systematic detection of electrophysiologic abnormalities in ICU patients might have prognostic value, since these abnormalities are associated with a high mortality keywords: abnormalities; cinma; electrophysiologic; icu; muscle; patients; studies cache: cord-005600-gsbbjb5y.txt plain text: cord-005600-gsbbjb5y.txt item: #44 of 440 id: cord-005603-kjcbbgse author: Brun-Buisson, C. title: The epidemiology of the systemic inflammatory response date: 2000 words: 7183 flesch: 44 summary: Severe sepsis and septic shock occur in 2 %–3 % of ward patients and 10 %–15 % or more ICU patients, depending on the case-mix; 25 % of patients with severe sepsis have shock. Severe sepsis and septic shock occur in 2 %±3 % of ward patients and 10 %±15 % or more ICU patients, depending on the case-mix; 25 % of patients with severe sepsis have shock. keywords: icu; infection; mortality; patients; sepsis; septic; shock; sirs; study cache: cord-005603-kjcbbgse.txt plain text: cord-005603-kjcbbgse.txt item: #45 of 440 id: cord-005606-c8c2rfzi author: Gordon, Sharon M. title: Clinical identification of cognitive impairment in ICU survivors: insights for intensivists date: 2004-10-02 words: 4675 flesch: 27 summary: Cognitive impairment is generally associated with inability to return to work, decreased quality of life and independence, and generalized functional decline; an important caveat to this observation, however, is that many investigations on the consequences of cognitive impairment have been carried out in populations with Alzheimer's disease, and may not be directly applicable to ICU survivors [20, 21, 22, 23] . The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study The epidemiology of dementia: Alzheimer's disease and vascular dementia Behavioral neurology Neuropsychological sequelae following acute respiratory distress syndrome: two year outcome Predictors of cognitive decline following coronary artery bypass graft surgery Postoperative hypoxia is a contributory factor to cognitive impairment after cardiac surgery The association between delirium and cognitive decline: a review of the empirical literature Cognitive impairment, dementia and quality of life in patients and caregivers A follow-up study of change in quality of life among persons with dementia residing in a long-term care facility The influence of cognitive impairment and psychiatric symptom on daily functioning in nursing facilities: a longitudinal study Quality of life in patients with traumatic brain injury-basic issues, assessment and recommendations Neurocognitive impairment influences quality of life in HIV-infected patients receiving HAART Cognitive impairment in adults with good recovery after bacterial meningitis Factors associated with perceived quality of life many years after traumatic brain injury Instrumental activities of daily living: a stepping stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment? keywords: care; dementia; depression; following; icu; impairment; patients; screening; survivors cache: cord-005606-c8c2rfzi.txt plain text: cord-005606-c8c2rfzi.txt item: #46 of 440 id: cord-005646-xhx9pzhj author: None title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72090 flesch: 51 summary: Objective: To assess the normal ,gastric intramucosal pH ~Hi) by tonometry in healthy children Patients and methods: Twelve healthy children (6 males and 6 females) with age rmaged from 6 months to 12 years scheduled for minor plastic or urologic surgery. Pain relief was good (VRS less 2) in 53 children -94.6 % of study patients. keywords: acute; administration; admission; age; airway; analysis; ards; arterial; average; babies; blood; brain; cardiac; care; cases; changes; chest; children; complications; conclusion; cpb; criteria; data; days; death; diagnosis; difference; disease; dose; drug; duration; ecmo; effects; failure; flow; gas; group; heart; high; hospital; hours; hypertension; icu; ill; incidence; increase; infants; infusion; initial; injury; intensive; levels; life; lung; management; mean; measurements; mechanical; median; medical; methods; minutes; months; mortality; neonatal; neonates; newborns; nitric; non; nurses; outcome; oxide; oxygenation; parameters; patients; peak; pediatric; period; phi; picu; plasma; post; present; pressure; prism; pulmonary; range; rate; response; results; risk; score; sepsis; severe; severity; study; support; surgery; survivors; syndrome; system; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; weeks; weight; years cache: cord-005646-xhx9pzhj.txt plain text: cord-005646-xhx9pzhj.txt item: #47 of 440 id: cord-005692-n4vxazst author: Papazian, Laurent title: Ventilator-associated pneumonia in adults: a narrative review date: 2020-03-10 words: 10366 flesch: 22 summary: The 2017 IDSA/ATS guidelines recommend empiric coverage of methicillin-resistant Staphylococcus aureus (MRSA) in patients who received antibiotics in the preceding 90 days or those hospitalized in units with high (> 20%) or unknown MRSA prevalence among VAP patients Although all-cause mortality associated with VAP has been reported to be as high as 50%, there is still considerable controversy regarding the extent to which VAP contributes to death in ICU patients. keywords: analysis; antibiotics; care; icu; mortality; pathogens; patients; pneumonia; prevention; rates; risk; study; treatment; trial; use; vap; ventilator cache: cord-005692-n4vxazst.txt plain text: cord-005692-n4vxazst.txt item: #48 of 440 id: cord-005727-li8pwigg author: None title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 words: 102900 flesch: 50 summary: Postoperative sedation with both midazolam and dexmedetomidine were effective in suppressing oxidative stress in ICU patients. Poorly controlled pain in the postoperative period can lead to slow recovery and life threatening complications, especially in elderly patients. The use of a tidal volume of 6 ml/kg of predicted body weight is part of the management of patients presenting with ARDS (1) and prevents ventilator induced lung injury in ICU patients undergoing mechanical ventilation (2) . keywords: acute; admission; adult patients; age; aim; analysis; apache; arrest; arterial; assessment; blood; brain; cardiac; care; care patients; care unit; changes; complications; conclusions; control; critical; daily; data; days; diagnosis; differences; discharge; disease; early; effects; factors; failure; family; flow; fluid; following; glucose; group; hospital; hospital mortality; hypothermia; icu admission; icu mortality; icu patients; incidence; increased; infection; injury; intensive; introduction; invasive; length; levels; lung; management; mean; measurement; median; medical; methods; min; mmol; model; monitoring; mortality; n =; niv; non; number; nurses; objectives; organ; outcome; oxygen; p =; parameters; patients; pct; period; post; pressure; prospective; range; rate; results; risk; score; sedation; sepsis; septic; shock; staff; stay; studies; study; support; surgery; survival; system; temperature; test; therapy; time; total; treatment; unit; use; value; vap; variables; ventilation; volume; years cache: cord-005727-li8pwigg.txt plain text: cord-005727-li8pwigg.txt item: #49 of 440 id: cord-005750-54hul2lw author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea date: 2009-02-10 words: 8237 flesch: 41 summary: Policies were not modified for child patients in 9% of ICUs, nor for a dying patient in 21%. [36] review a few recent randomized clinical trials performed on severely ill patients (the ARMA trial comparing a low and a lage Vt in ARDS, the trial assessing the effect of growth hormone in ICU patients and the TRICC trial, on the level of blood transfusion, also in ICU patients) and emphasise the crucial importance of the control group. keywords: acute; authors; cardiac; care; children; critical; end; et al; icu; intensive; life; mortality; paediatric; patients; risk; shock; study; use cache: cord-005750-54hul2lw.txt plain text: cord-005750-54hul2lw.txt item: #50 of 440 id: cord-005777-6rvfsx4p author: None title: PS 0420-0716 date: 2007-08-25 words: 59296 flesch: 50 summary: The aim of this study was to determine the risk factors and mortality rate of acinetobacter baumanii infections in ICU patients. It has been considered to play a role in worsening the prognosis of ICU patients. keywords: acute; admission; age; aim; analysis; apache; ards; ards patients; arterial; blood; cardiac; care; cases; complications; conclusion; control; data; days; dose; factors; failure; function; group; hospital; hours; icu; icu mortality; icu patients; incidence; increase; infection; infusion; injury; intensive; lactate; length; levels; liver; lung; mean; median; medical; mortality; non; outcome; parameters; patients; peep; period; pneumonia; pressure; pts; pulmonary; rate; ratio; results; risk; score; sepsis; septic; serum; shock; stay; study; surgery; test; therapy; time; total; tracheostomy; treatment; unit; use; values; ventilation; years cache: cord-005777-6rvfsx4p.txt plain text: cord-005777-6rvfsx4p.txt item: #51 of 440 id: cord-005795-sgi54hq8 author: Ely, E. title: The impact of delirium in the intensive care unit on hospital length of stay date: 2001-11-08 words: 4880 flesch: 36 summary: In this investigation, we found that ICU patients had an inordinately high number of risk factors to develop delirium. Patients with three or more of these risk factors have been considered ªhigh riskº for delirium [2, 14, 40, 43] , and in ICU patients, this magnitude of risk is nearly universal. keywords: care; delirium; hospital; icu; length; patients; risk; stay; study cache: cord-005795-sgi54hq8.txt plain text: cord-005795-sgi54hq8.txt item: #52 of 440 id: cord-005808-w0763esk author: Moreno, Gerard title: Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study date: 2018-08-03 words: 5152 flesch: 33 summary: Because Cox hazard survival analysis is not satisfactory for describing ICU patient mortality over time [33] , we performed a competing risks analysis to confirm our results. Therefore, the aim of the present study was to identify the factors associated with corticosteroid use and its impact on intensive care unit (ICU) mortality using propensity score (PS) matching analysis in ICU patients with influenza pneumonia. keywords: analysis; corticosteroid; data; hospital; icu; infection; influenza; mortality; patients; pneumonia; study; therapy; treatment; use cache: cord-005808-w0763esk.txt plain text: cord-005808-w0763esk.txt item: #53 of 440 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #54 of 440 id: cord-005816-i54q5gsu author: None title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 words: 83218 flesch: 50 summary: Liberal utilization of abdominal sonography and abdominal CT scan may reduce missed acute abdomen in abdominal pain patients and appropriate radiological imaging and meticulous evaluation of the X-rays may reduce unnoticed spinal, pelvic and facial fractures in trauma patients. The e-mail noticed us, the presenting author of this abstract (Akira Endo) posted 3 or more abstract as a presenting author, however, the authors of 'Increased mortality in trauma patients with systolic hypertension' believed that Akira Endo in Department of ACCDM, TMDU, Japan surely posted this abstract only. keywords: abdomen; abdominal; acute; admission; age; aim; appendicitis; approach; area; artery; average; bleeding; blood; blunt; bone; burn; burn patients; care; cases; cause; chest; colon; complications; conclusion; control; data; days; department; diagnosis; disease; emergency; evaluation; examination; factors; female; findings; fixation; follow; fractures; general; good; group; head; healing; hospital; infection; initial; injuries; injury; introduction; knee; laparotomy; left; liver; male; management; mean; medical; methods; months; morbidity; mortality; n =; number; operation; outcome; p =; pain; patients; penetrating; perforation; period; postoperative; present; procedure; range; rate; reduction; results; right; risk; score; second; severity; stay; study; surgery; system; technique; time; tissue; total; trauma patients; treatment; type; weeks; wound; years cache: cord-005816-i54q5gsu.txt plain text: cord-005816-i54q5gsu.txt item: #55 of 440 id: cord-005881-oswgjaxz author: None title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 words: 72013 flesch: 48 summary: The aim of this study was therefore to establish the impact of anaemia and blood transfusion on postoperative recovery of hip fracture patients. We assessed the adherence of these guidelines on the initial pre-operative management of tetanus prone open orthopaedic injuries in trauma patients admitted for surgery. keywords: acute; age; aim; analysis; approach; average; bone; care; cases; complications; conclusion; control; data; days; difference; disclosure; emergency; evaluation; failure; fixation; follow; fracture patients; fractures; good; group; head; healing; hospital; incidence; infection; injuries; injury; introduction; knee; liver; long; management; material; mean; medical; methods; months; mortality; nail; non; number; operation; operative; osteosynthesis; outcome; pain; patients; period; plate; postoperative; procedure; range; rate; reduction; relationships; repair; results; risk; score; screw; standard; stiffness; studies; study; surgery; system; technique; tibial; time; tissue; total; training; trauma patients; treatment; type; use; weeks; wound; years cache: cord-005881-oswgjaxz.txt plain text: cord-005881-oswgjaxz.txt item: #56 of 440 id: cord-006182-kck5e1ry author: None title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 words: 87787 flesch: 45 summary: Whether a laboratory response in coagulation dosing, laboratory response, hemostatic efficacy and patient outcomes. A project aimed at improving DI management through predictive assessments and DDAVP protocols could potentially improve patient outcomes. keywords: acute; admission; adult patients; analysis; arrest; arrest patients; asah; associated; association; baseline; blood; brain; brain injury; cardiac; care; case; center; cerebral; changes; cohort; common; complications; data; days; dci; death; diagnosis; difference; discharge; disease; dose; edema; eeg; factors; functional; gcs; group; hemorrhage; higher; hospital; hours; ich patients; icp; icu; imaging; improvement; initial; injury; intervention; intracranial; ischemic; left; levels; management; mean; median; medical; monitoring; mortality; mri; mrs; neurocritical; new; non; outcome; patients; post; pressure; primary; rate; related; results; review; risk; sah; sah patients; scale; score; seizures; status; stroke; stroke patients; studies; study; subarachnoid; tbi patients; test; therapeutic; therapy; time; total; treatment; ttm; unit; use; vasospasm; years cache: cord-006182-kck5e1ry.txt plain text: cord-006182-kck5e1ry.txt item: #57 of 440 id: cord-006308-s5le8ugm author: Dimopoulos, G. title: Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study date: 2007-05-25 words: 4722 flesch: 42 summary: Oropharyngeal candidiasis was detected in 5 of 9 (55.5%) IC patients and in 1 of 15 (6.5%) NIC patients (p = 0.015). Oropharyngeal candidiasis was detected in 5 of 9 (55.5%) IC patients and in 1 of 15 (6.5%) NIC patients (p= 0.015). keywords: candida; candidemia; candidiasis; icu; nic; patients; study cache: cord-006308-s5le8ugm.txt plain text: cord-006308-s5le8ugm.txt item: #58 of 440 id: cord-006366-qpjvmwmp author: Kinikar, Aarti Avinash title: Predictors of Mortality in Hospitalized Children with Pandemic H1N1 Influenza 2009 in Pune, India date: 2011-10-20 words: 3314 flesch: 39 summary: Of 775 pediatric cases admitted with Influenza Like Illness (ILI), 92 (11.8%) had confirmed H1N1 influenza infection. H1N1 infection caused significant pneumonia and ARDS, and resulted in ICU admissions and deaths in 96% and 16% of children, respectively. keywords: admission; children; h1n1; hospital; infection; influenza; mortality; pandemic cache: cord-006366-qpjvmwmp.txt plain text: cord-006366-qpjvmwmp.txt item: #59 of 440 id: cord-006545-c12m75gq author: Pinilla, Inmaculada title: Radiological prognostic factors in patients with pandemic H1N1 (pH1N1) infection requiring hospital admission date: 2011-05-27 words: 3048 flesch: 42 summary: [10] , although their study was carried out in patients under 20 years of age, and it has been communicated that severe cases among pediatric patients occur predominantly in children with underlying conditions, while adults seem to have severe viral pneumonia and ARDS often in previously healthy subjects [6] . This pattern, which is rare on other series of adult patients with pH1N1 infection, may be explained by the inclusion of very young patients, between 14 and 20 years in our cohort. keywords: admission; chest; h1n1; icu; influenza; patients cache: cord-006545-c12m75gq.txt plain text: cord-006545-c12m75gq.txt item: #60 of 440 id: cord-006714-q7wy76e2 author: Delannoy, P.-Y. title: Impact of combination therapy with aminoglycosides on the outcome of ICU-acquired bacteraemias date: 2012-02-15 words: 2881 flesch: 41 summary: ICU patients with or without bacteraemia have an increased volume of distribution. Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? keywords: bacteraemia; beta; combination; icu; patients; therapy cache: cord-006714-q7wy76e2.txt plain text: cord-006714-q7wy76e2.txt item: #61 of 440 id: cord-006760-mgrxo21j author: Lee, James C. title: Critical care management of the lung transplant recipient date: 2012-06-22 words: 5046 flesch: 29 summary: Given the severity of illness of such patients at the time of surgery, lung transplant recipients require particular attention in the immediate post-operative period to ensure optimal short-term and long-term outcomes. Causes and treatment of conditions affecting early morbidity and mortality in lung transplant recipients will be detailed, including primary graft dysfunction, cardiovascular and surgical complications, and immunologic and infectious issues. keywords: care; complications; donor; lung; management; patients; pulmonary; recipient; risk; transplant; transplantation cache: cord-006760-mgrxo21j.txt plain text: cord-006760-mgrxo21j.txt item: #62 of 440 id: cord-006869-g2q1gpp0 author: None title: Neurocritical Care Society 7th Annual Meeting date: 2009-10-08 words: 45443 flesch: 47 summary: In an IRB approved, prospective, open-label single-blinded Phase I study, SAH patients with elevated transcranial Doppler (TCD) velocities and Lindegaard Indices suggesting cVSP were enrolled. SAH patients were prospectively entered into an institutional database; those with myopathy were retrospectively identified. keywords: acute; admission; analysis; aneurysm; blood; brain; care; cases; cerebral; control; data; days; death; diagnosis; eeg; glucose; grade; group; hemorrhage; hospital; hours; hypothermia; ich; icp; icu; injury; intracranial; levels; mean; median; medical; monitoring; mortality; neurocritical; non; outcome; patients; pressure; risk; sah; sah patients; scale; score; serum; status; stroke; studies; study; subarachnoid; tbi; temperature; therapy; time; treatment; use; vasospasm; vs.; years cache: cord-006869-g2q1gpp0.txt plain text: cord-006869-g2q1gpp0.txt item: #63 of 440 id: cord-006870-f5w6fw6q author: None title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date: 2017-09-19 words: 122395 flesch: 46 summary: The best model fit was for good outcome (modified Rankin Score 0-2 equivalents) based on % patients with WFNS 4-5 and age (R2=0.54; p<0.001). Decreasing time spent in cervical spinal immobilization could improve patient care by allowing greater access to / range-of-motion of the neck, increasing patient comfort, and decreasing skin breakdown. keywords: acute; administration; admission; adult patients; analysis; arrest; asah; associated; baseline; blood; brain; brain injury; cardiac; care patients; care unit; case; center; cerebral; cohort; common; complications; data; days; death; diagnosis; difference; discharge; duration; early; edema; eeg; effect; epilepticus; evd; factors; findings; following; gcs; group; head; hematoma; hemorrhage; hemorrhage patients; hospital; hours; ich; ich patients; icp; icu; identified; imaging; improvement; infusion; initial; injury; intracerebral; intracranial; ischemic; left; level; los; management; mean; median; medical; minutes; model; monitoring; months; mortality; mri; neurocritical; new; non; number; outcome; patients; period; placement; population; post; presence; present; pressure; primary; prior; prospective; rate; refractory; related; report; results; review; right; risk; risk patients; sah patients; scale; score; secondary; seizures; srse; status; stay; stroke patients; studies; study; subarachnoid; surgery; tbi; tbi patients; test; therapy; time; total; treatment; unit; use; years cache: cord-006870-f5w6fw6q.txt plain text: cord-006870-f5w6fw6q.txt item: #64 of 440 id: cord-006876-v2m5l5wz author: None title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 words: 59827 flesch: 46 summary: However, the trend was not uniform -48% patients had no correlation between rSO2 and CPP, 29% showed a positive correlation and 23% showed a negative correlation. Major reasons for satisfaction included: physician response to emergencies, physician -nurse communication, and patient outcome. keywords: acute; admission; analysis; arrest; asah; associated; baseline; blood; brain; brain injury; cardiac; care; care patients; care unit; case; center; cerebral; cohort; complications; data; days; death; developed; discharge; dose; duration; eeg; following; gcs; group; hemorrhage; hospital; hours; ich; ich patients; icp; icu; impact; injury; intensive; intracranial; management; mean; median; medical; model; monitoring; months; mortality; neurocritical; neurological; new; non; onset; outcome; patients; pcc; post; pressure; primary; rate; results; review; sah; sah patients; score; seizures; status; studies; study; subarachnoid; tbi; therapy; time; total; treated; treatment; unit; use; years cache: cord-006876-v2m5l5wz.txt plain text: cord-006876-v2m5l5wz.txt item: #65 of 440 id: cord-006880-9dgmdtj8 author: None title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 words: 82474 flesch: 47 summary: Included patients were 55.5 ±15.2 years old with female preponderance (65.5%, (76/116)). Admission NIHSS was 11 for ICU patients and 9 for SU patients (NS). keywords: acute; admission; adult patients; analysis; aneurysm; arrest; arrest patients; asah; blood; brain; brain injury; cardiac; care; case; center; cerebral; cohort; coma; complications; data; days; dci; death; diagnosis; discharge; early; factors; following; gcs; good; group; head; hemorrhage; high; hospital; hours; hypothermia; ich; icp; icu; icu patients; imaging; increase; initial; injury; intracranial; ischemic; levels; management; mean; median; medical; monitoring; mortality; mri; mrs; neurocritical; non; onset; outcome; patients; poor; post; present; pressure; rate; regression; results; review; risk; sah; sah patients; scale; score; status; stroke patients; studies; study; subarachnoid; surgical; tbi; tbi patients; therapeutic; therapy; time; total; traumatic; treatment; unit; use; vasospasm; vs.; years cache: cord-006880-9dgmdtj8.txt plain text: cord-006880-9dgmdtj8.txt item: #66 of 440 id: cord-006975-u5ecibta author: Haviland, Kelly title: Outcomes after long-term mechanical ventilation of cancer patients date: 2020-03-30 words: 3622 flesch: 46 summary: Again, the 1-year overall survival for weaned patients in our study was similar to survival rates in previous reports including non-cancer patients. We sought to determine the probability of weaning and overall survival of cancer patients requiring long-term mechanical ventilation in a specialized weaning unit. keywords: care; days; patients; survival; ventilation; weaning cache: cord-006975-u5ecibta.txt plain text: cord-006975-u5ecibta.txt item: #67 of 440 id: cord-007560-nck4f5ny author: Ling, Lowell title: COVID-19: A critical care perspective informed by lessons learnt from other viral epidemics date: 2020-02-20 words: 2810 flesch: 34 summary: First case of 2019 novel Coronavirus in the United States Angiotensinconverting enzyme 2 is a functional receptor for the SARS coronavirus A pneumonia outbreak associated with a new coronavirus of probable bat origin The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus-infected pneumonia in Wuhan, China Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore Which preventive measures might protect health care workers from SARS? Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review Clinical management and infection control of SARS: lessons learned Ventilation of wards and nosocomial outbreak of severe acute respiratory syndrome among healthcare workers Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada Transmission of SARS to healthcare workers. The experience of a Hong Kong ICU Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure: a meta-analysis of randomized controlled trials Transmission of severe acute respiratory syndrome during intubation and mechanical ventilation High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/H1N1v Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi Can breathing circuit filters help prevent the spread of influenza A (H1N1) virus from intubated patients? Influence of residency training on multiple attempts at endotracheal intubation Mechanical ventilation in an airborne epidemic Videolaryngoscopy versus direct laryngoscopy for adult patients requiring tracheal intubation Possible SARS coronavirus transmission during cardiopulmonary resuscitation Clinical review: SARS -lessons in disaster management Report of the Select Committee to inquire into the handling of the Severe Acute Respiratory Syndrome outbreak by the Government and the Hospital Authority Expanding ICU facilities in an epidemic: recommendations based on experience from the SARS epidemic in Hong Kong and Singapore Augmentation of hospital critical care capacity after bioterrorist attacks or epidemics: recommendations of the Working Group on Emergency Mass Critical Care Critical care triage. keywords: care; coronavirus; covid-19; icu; patients; risk; sars; transmission cache: cord-007560-nck4f5ny.txt plain text: cord-007560-nck4f5ny.txt item: #68 of 440 id: cord-007818-jfp9uumb author: Papali, Alfred title: Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings date: 2019-02-09 words: 15076 flesch: 28 summary: We suggest that, if possible, ICUs use a closed-format model where physicians specifically trained or experienced in intensive care medicine direct patient care (2B). Controlled trial of upper room ultraviolet air disinfection: a basis for new dosing guidelines Guidelines for prevention of hospital acquired infections Guide to local production: WHO-recommended handrub formulations Shelf-life of chlorine solutions recommended in Ebola virus disease response Cost-effectiveness of a hand hygiene program on health care-associated infections in intensive care patients at a tertiary care hospital in Vietnam Cluster-randomized, crossover trial of the efficacy of plain soap and water versus alcohol-based rub for surgical hand preparation in a rural hospital in Kenya Muslim health-care workers and alcoholbased handrubs Current practices and barriers to the use of facemasks and respirators among hospital-based health care workers in Vietnam A cluster randomised trial of cloth masks compared with medical masks in healthcare workers Infection prevention and control (IPC) guidance summary: Ebola guidance package An approach to prioritization of medical devices in low-income countries: an example based on the Republic of South Sudan Determining the utility and durability of medical equipment donated to a rural clinic in a low-income country Mortality rates increase dramatically below a systolic blood pressure of 105-mm Hg in septic surgical patients Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial International study on microcirculatory shock occurrence in acutely ill patients Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3) Diagnosing acute respiratory distress syndrome in resource limited settings: the Kigali modification of the Berlin definition Hypoxaemia as a mortality risk factor in acute lower respiratory infections in children in low and middle-income countries: systematic review and meta-analysis Prevalence and predictors of hypoxaemia in respiratory and non-respiratory primary diagnoses among emergently ill children at a tertiary hospital in south western Nigeria Single deranged physiologic parameters are associated with mortality in a low-income country Severely deranged vital signs as triggers for acute treatment modifications on an intensive care unit in a lowincome country Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scaleup: a longitudinal cohort study Dynamic measurement of hemodynamic parameters and cardiac preload in adults with dengue: a prospective observational study Vital signs directed therapy: improving care in an intensive care unit in a low-income country Accuracy of oscillometric blood pressure measurement according to the relation between cuff size and upper-arm circumference in critically ill patients Tracking hypotension and dynamic changes in arterial blood pressure with brachial cuff measurements Results of a survey of blood pressure monitoring by intensivists in critically ill patients: a preliminary study Pulse oximetry for perioperative monitoring The use of the pulse oximetric saturation/fraction of inspired oxygen ratio for risk stratification of patients with severe sepsis and septic shock Ventilatory support of patients with sepsis or septic shock in resource-limited settings The use of portable ultrasound devices in low-and middle-income countries: a systematic review of the literature Impact of improved vaccination programme and intensive care facilities on incidence and outcome of tetanus in southern Vietnam Neonatal tetanus in Vietnam: comprehensive intensive care support improves mortality Impact of a structured ICU training programme in resource-limited settings in Asia Non-invasive ventilation for children with acute respiratory failure in the developing world: literature review and an implementation example Noninvasive mechanical ventilation: an 18-month experience of two tertiary care hospitals in north India A randomized clinical trial evaluating nasal continuous positive airway pressure for acute respiratory distress in a developing country Bubble continuous positive airway pressure for children with severe pneumonia and hypoxaemia in Bangladesh: an open, randomised controlled trial Use of nasal bubble CPAP in children with hypoxemic clinical pneumonia-report from a resource limited set-up Efficacy of a lowcost bubble CPAP system in treatment of respiratory distress in a neonatal ward in Malawi Continuous end-tidal carbon dioxide monitoring in pediatric intensive care units The use of end-tidal carbon dioxide monitoring to confirm endotracheal tube placement in adult and paediatric intensive care units in Australia and New Zealand keywords: blood; care; countries; critical; equipment; hand; healthcare; hospital; hygiene; icu; icus; infection; intensive; medicine; mortality; national; oxygen; patients; quality; resource; sepsis; settings; studies; study; supply; training; use cache: cord-007818-jfp9uumb.txt plain text: cord-007818-jfp9uumb.txt item: #69 of 440 id: cord-009417-458rrhcm author: Luce, Judith A. title: Use of Blood Components in the Intensive Care Unit date: 2009-05-15 words: 17116 flesch: 37 summary: Oxygen extraction ratio: A valid indicator of transfusion need in limited coronary vascular reserve? for the ABC Investigators: Anemia and blood transfusion in critically ill patients The CRIT study: Anemia and blood transfusion in the critically ill-current clinical practice in the United States Red cell transfusion practice following the Transfusion Requirements in Critical Care (TRICC) study: Prospective observational cohort study in a large UK intensive care unit Appropriateness of red blood cell transfusion in Australasian intensive care practice Silent myocardial ischaemia and haemoglobin concentration: A randomized controlled trial of transfusion strategy in lower limb arthroplasty Mathematical analysis of isovolemic hemodilution indicates that it can decrease the need for allogeneic blood transfusion Guidelines for perioperative red blood cell transfusions American Society of Anesthesiologists Task Force: Practice guidelines for blood component therapy Prudent strategies for elective red blood cell transfusion Platelet transfusion therapy. The majority of blood transfusions are in the form of PRBCs, the component indicated for normovolemic patients or those for whom intravascular volume constraints are necessary. keywords: acute; associated; benefi; bleeding; blood; blood transfusion; care; cell; coagulation; components; disease; donor; factor; ffp; oxygen; patients; plasma; platelet; reactions; recipient; red; risk; storage; time; transfusion; transmission; unit; use; volume cache: cord-009417-458rrhcm.txt plain text: cord-009417-458rrhcm.txt item: #70 of 440 id: cord-010566-tciwtxud author: Singh, Nina title: Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality date: 1998 words: 3674 flesch: 34 summary: 35 Mental status has been shown to be a significant predictor of outcome in ICU patients in a number of clinical settings, e.g., patients with acute renal failure requiring dialysis and transplant recipients. 9,10 Acute physiology and chronic health evaluation (APACHE) scores were determined to be of prognostic significance in a study in ICU patients with cirrhosis; however, neither Child-Pugh scores nor etiology of liver disease were assessed in that study. keywords: cirrhosis; icu; liver; mortality; patients; scores cache: cord-010566-tciwtxud.txt plain text: cord-010566-tciwtxud.txt item: #71 of 440 id: cord-010775-1f9g4t5y author: Labeau, S. O. title: Less daily oral hygiene is more in the ICU: not sure date: 2020-04-01 words: 1312 flesch: 35 summary: Additionally, we welcome all further evidence clarifying the contribution of oral care interventions to the prevention of pneumonia and the current concerns regarding the safety of CHG oral care. key: cord-010775-1f9g4t5y authors: Labeau, S. O.; Conoscenti, E.; Blot, S. I. title: Less daily oral hygiene is more in the ICU: not sure date: 2020-04-01 journal: Intensive Care Med DOI: 10.1007/s00134-020-06021-6 sha: doc_id: 10775 cord_uid: 1f9g4t5y nan The interest in research on oral care in intensive care unit (ICU) patients has emerged largely from the 2000s onward after years of being a rather ignored topic in health science. keywords: care; evidence; icu; patients cache: cord-010775-1f9g4t5y.txt plain text: cord-010775-1f9g4t5y.txt item: #72 of 440 id: cord-010813-94v8zchf author: Deemer, Kirsten title: Effect of early cognitive interventions on delirium in critically ill patients: a systematic review date: 2020-04-24 words: 6196 flesch: 31 summary: Feasibility of cognitive interventions was measured in three studies. This review may help to promote future large, multi-centre trials studying the addition of cognitive interventions to current delirium prevention practices. keywords: bias; care; data; delirium; interventions; outcomes; patients; review; risk; studies; study cache: cord-010813-94v8zchf.txt plain text: cord-010813-94v8zchf.txt item: #73 of 440 id: cord-010980-sizuef1v author: None title: ECTES Abstracts 2020 date: 2020-05-11 words: 132805 flesch: 50 summary: Investigation of coagulopathies and its relevance with mortality and transfusion rates using thromboelastography in trauma patients Introduction: Inter-hospital variation in surgical intensity for trauma admissions: a multicenter cohort study L. Moore 1 , M. P. Patton 2 , I. Farhat 2 , P. A. Tardif 2 , C. Gonthier 3 , A. Belcaid 3 , F. Lauzier 2 , A. Turgeon 2 , J. Clément 2 1 Université Laval, Social and preventive medicine, québec, Canada, 2 CHU de Québec-Université-Laval, Québec, Canada, 3 Introduction: Guidelines for trauma patients are increasingly moving away from surgical management towards less invasive procedures but there is a knowledge gap on how these recommendations are influencing practice. keywords: 0.001; abdomen; abdominal; acute; admission; adult patients; age; aim; analysis; approach; average; bleeding; blood; blunt; bone; brain; cases; cause; chest; clinical; cohort; cohort study; comments; complications; conclusions; control; data; days; death; department; diagnosis; emergency; emergency surgery; factors; findings; fixation; follow; following; fractures; general; good; grade; group; head; hip; history; hospital; hospital mortality; icu; incidence; increased; injuries; injury; injury severity; introduction; investigation; iss; laparotomy; left; level; literature; male; management; material; mean; mechanism; median; medical; methods; model; months; mortality; mortality rate; neck; need; non; number; open; operative; outcomes; p =; pain; patients c; patients introduction; pelvic; period; plate; polytrauma patients; population; postoperative; pressure; primary; procedure; progressions; range; rate; reduction; results; review; right; risk; scan; score; screw; severity; shock; stay; studies; study; study introduction; surgeons; surgery; surgery patients; survival; system; technique; test; therapy; time; tissue; total; transfusion; trauma care; trauma center; trauma patients; trauma registry; trauma surgery; trauma team; treatment; type; university; use; vascular; wound; years cache: cord-010980-sizuef1v.txt plain text: cord-010980-sizuef1v.txt item: #74 of 440 id: cord-011029-sbds5sda author: Portran, Philippe title: Improving the prognostic value of ∆PCO(2) following cardiac surgery: a prospective pilot study date: 2019-07-10 words: 4597 flesch: 45 summary: Relation between oxygen consumption and oxygen delivery in patients after cardiac surgery Blood lactate and mixed venous-arterial PCO2 gradient as indices of poor peripheral perfusion following cardiopulmonary bypass surgery Frequency, risk factors, and outcome of hyperlactatemia after cardiac surgery Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis Even mild hyperlactatemia is associated with increased mortality in critically ill patients Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock Type B lactic acidosis following cardiopulmonary bypass Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis Mixed venous oxygen saturation predicts short-and long-term outcome after coronary artery bypass grafting surgery: a retrospective cohort analysis S3 Guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system Central venous-arterial pCO2 difference identifies microcirculatory hypoperfusion in cardiac surgical patients with normal central venous oxygen saturation: a retrospective analysis Central venous O 2 saturation and venous-to-arterial CO 2 difference as complementary tools for goal-directed therapy during high-risk surgery Central venous-to-arterial carbon dioxide difference as a prognostic tool in high-risk surgical patients ) difference during regional ischemic or hypoxic hypoxia High veno-arterial carbon dioxide gradient is not predictive of worst outcome after an elective cardiac surgery: a retrospective cohort study A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients Detailing the cardiovascular profile in shock patients The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the working group on sepsis-related problems of the european society of intensive care medicine Acute kidney injury Network: report of an initiative to improve outcomes in acute kidney injury Central venous-arterial carbon dioxide difference as an indicator of cardiac index Venoarterial CO2 gradient after cardiac surgery: relation to systemic and regional perfusion and oxygen transport High central venous saturation after cardiac surgery is associated with increased organ failure and long-term mortality: an observational cross-sectional study Low and supranormal central venous oxygen saturation and markers of tissue hypoxia in cardiac surgery patients: a prospective observational study Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock? Combination of arterial lactate levels and venous-arterial CO 2 to arterial-venous O 2 content difference ratio as markers of resuscitation in patients with septic shock No agreement of mixed venous and central venous saturation in sepsis, independent of sepsis origin Acknowledgements The proofreading of this article was supported by the Bibliothèque Scientifique de l'Internat de Lyon and the Hospices Civils de Lyon. Conflict of interest The authors declare that they have no conflict of interest. keywords: ero; icu; lactate; patients; risk; surgery; δpco cache: cord-011029-sbds5sda.txt plain text: cord-011029-sbds5sda.txt item: #75 of 440 id: cord-011159-k2kca8zl author: Kamel, Toufik title: Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study date: 2020-01-07 words: 5116 flesch: 40 summary: BAL respiratory tolerance was first assessed by recording the need for modification(s) in respiratory support as previously described [8] from the beginning of bronchoscopy to 24 h after, including need of tracheal intubation, increase by more than 50% in oxygen flow rate, or use of HFNC in patients under standard oxygen therapy, increase by more than 20% in gas flow rate or FiO 2 in patients initially under HFNC, need of non-invasive ventilation (NIV) in patients who initially had no mechanical respiratory support and increase by more than 20% in inspiratory pressure support or in positive end-expiratory pressure or in FiO 2 , in patients initially treated by NIV. Patients were included if (1) they had an indication to undergo a BAL as decided by their attending intensivist, (2) cellular analysis of BAL fluid by a pathologist was planned, and (3) consent had been obtained. keywords: bal; bronchoscopy; events; fluid; non; oxygen; patients; physician; study cache: cord-011159-k2kca8zl.txt plain text: cord-011159-k2kca8zl.txt item: #76 of 440 id: cord-011189-c0ytamge author: da Fonseca Pestana Ribeiro, Jose Mauro title: Less empiric broad-spectrum antibiotics is more in the ICU date: 2019-11-27 words: 1623 flesch: 22 summary: Several adverse effects related to antibiotic use are described in the literature; with acquired multidrug resistance (MDR) being the most concerning effect. De-escalation decreases the time of antibiotic use, but a short exposure still exists; in this way, a single antibiotic dose may be enough to treat severe infections such as Fig. keywords: antibiotics; care; patients; sepsis; use cache: cord-011189-c0ytamge.txt plain text: cord-011189-c0ytamge.txt item: #77 of 440 id: cord-011210-afcmln4w author: Olsen, Markus Harboe title: Automated pupillometry and the FOUR score — what is the diagnostic benefit in neurointensive care? date: 2020-05-07 words: 3439 flesch: 37 summary: GCS scores > Fig. 2 Scatter plot illustrating the relationship between GCS score and FOUR score, again showing that patients with a GCS score of 3 may score very differently on the FOUR (from 0 to 6). keywords: gcs; inspection; patients; pupillary; pupillometry; score cache: cord-011210-afcmln4w.txt plain text: cord-011210-afcmln4w.txt item: #78 of 440 id: cord-011211-79stfqrd author: Robba, Chiara title: Tracheostomy practice and timing in traumatic brain-injured patients: a CENTER-TBI study date: 2020-02-05 words: 4826 flesch: 44 summary: Early tracheostomy is associated with a better neurological outcome and reduced LOS, but the causality of this relationship remains unproven. Early tracheostomy is associated with shorter ICU length of stay and with a trend of a better outcome. keywords: days; icu; injury; los; patients; tbi; tracheostomy cache: cord-011211-79stfqrd.txt plain text: cord-011211-79stfqrd.txt item: #79 of 440 id: cord-011314-at65nvda author: De Weerdt, Annick title: Pre-admission air pollution exposure prolongs the duration of ventilation in intensive care patients date: 2020-03-17 words: 4062 flesch: 30 summary: The association between ventilation duration and air pollution exposure was investigated by negative binomial regression, using a separate model for each of the four pollutants. Reported estimates represent the lag-specific and cumulative (lag0-10 days) percentage change (with 95% confidence intervals [CI]) in ventilation duration for an interquartile range (IQR) increase in air pollution exposure. keywords: admission; air; duration; exposure; icu; patients; pollution; ventilation cache: cord-011314-at65nvda.txt plain text: cord-011314-at65nvda.txt item: #80 of 440 id: cord-011327-zsoc4wec author: Martin-Loeches, Ignacio title: Antibiotic prophylaxis in the ICU: to be or not to be administered for patients undergoing procedures? date: 2019-11-28 words: 1974 flesch: 19 summary: Antimicrobial prophylaxis may be administered to patients undergoing a surgical procedure during their ICU stay and as a non-surgical prophylaxis to ICU patients who undergo insertion of an external-internal foreign body that remains in situ for a prolonged period of time. There are no randomised controlled trials on the effects of timing or choice of antibiotic prophylaxis on the outcomes of ICU patients requiring unplanned surgical procedures. keywords: antibiotic; icu; patients; pneumonia; prophylaxis cache: cord-011327-zsoc4wec.txt plain text: cord-011327-zsoc4wec.txt item: #81 of 440 id: cord-011332-dzl09afq author: Stoclin, A. title: Ventilator-associated pneumonia and bloodstream infections in intensive care unit cancer patients: a retrospective 12-year study on 3388 prospectively monitored patients date: 2019-04-17 words: 3245 flesch: 51 summary: Some publications suggest high rates of healthcare-associated infections (HAIs) and of nosocomial pneumonia portending a poor prognosis in ICU cancer patients. The occurrence of device-associated infections is essentially due to severe medical conditions in patients and to the characteristics of the malignancy, but these infections do not influence the outcome of ICU cancer patients. keywords: bsis; icu; infections; patients; risk; stays; vap cache: cord-011332-dzl09afq.txt plain text: cord-011332-dzl09afq.txt item: #82 of 440 id: cord-011359-3lcjw873 author: De Waele, Jan J. title: Antimicrobial de-escalation as part of antimicrobial stewardship in intensive care: no simple answers to simple questions—a viewpoint of experts date: 2020-02-05 words: 4817 flesch: 24 summary: Even if it appears beneficial, ADE may have some unwanted side effects: it has been associated with prolongation of antimicrobial therapy and could inappropriately be used as a justification for unrestricted broadness of empirical therapy. 1 Schematic overview of the timeline of antimicrobial therapy including antimicrobial de-escalation, with the pivotal and companion antimicrobial components of the empirical regimen and most common changes within a short antibiotic course for critically ill patients with an infection. keywords: ade; antibiotic; antimicrobial; escalation; patients; spectrum; therapy; treatment; use cache: cord-011359-3lcjw873.txt plain text: cord-011359-3lcjw873.txt item: #83 of 440 id: cord-011418-hy8xmtiq author: Walz, Alice title: The ICU Liberation Bundle and Strategies for Implementation in Pediatrics date: 2020-05-16 words: 5260 flesch: 28 summary: Okla Nurse Distraction using the BUZZY for children during an IV insertion Relief of pain and anxiety in pediatric patients in emergency medical systems Pain outcomes in a US children's hospital: a prospective cross-sectional survey Ventilator-associated lung injury Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American college of chest physicians; the American association for respiratory care; and the American college of critical medicine Early intensive care sedation predicts long-term mortality in ventilated critically ill patients Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation Practice patterns and outcomes associated with early sedation depth in mechanically ventilated patients: a systematic review and meta-analysis Analgosedation: a paradigm shift in intensive care unit sedation practice Validity of the Richmond Agitation-Sedation Scale (RASS) in critically ill children Assessment of sedation levels in pediatric intensive care patients can be improved by using the COMFORT behavior scale. Pediatr Crit Care Med Early exercise in critically ill youth and children, a preliminary evaluation: the wEECYCLE pilot trial Early protocolized versus usual care rehabilitation for pediatric neurocritical care patients: a randomized controlled trial Mobilization therapy in the pediatric intensive care unit: a multidisciplinary quality improvement initiative Implementation of an ICU Bundle: an interprofessional quality improvement project to enhance delirium management and monitor delirium prevalence in a single PICU Pediatric cohort study showing physical improvement in pediatric liver Family presence: Visitation in the adult ICU. keywords: bundle; care; children; delirium; icu; implementation; pain; patients; pediatric; picu; sedation; use cache: cord-011418-hy8xmtiq.txt plain text: cord-011418-hy8xmtiq.txt item: #84 of 440 id: cord-011483-zc6ve6le author: Leclerc, Angela M. title: Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients date: 2020-05-20 words: 5734 flesch: 40 summary: This study represents the largest cohort of stroke patients treated with neurostimulants during their acute hospitalization, and suggests amantadine started in the first week after stroke may be associated with improved wakefulness or responsiveness in approximately half of treated patients. Due to the paucity of published data for stroke patients treated with neurostimulants in the acute setting, no protocols or robust data were available to guide us or allow for a power calculation. keywords: acute; administration; amantadine; modafinil; n =; neurostimulant; patients; rehabilitation; stroke; study cache: cord-011483-zc6ve6le.txt plain text: cord-011483-zc6ve6le.txt item: #85 of 440 id: cord-012560-p5s0p7fd author: Decavèle, Maxens title: One-year survival of patients with high-grade glioma discharged alive from the intensive care unit date: 2020-08-29 words: 3720 flesch: 39 summary: Because the prognosis of cancer patients is similar to that of non-cancer patients [1, 3] , a diagnosis of cancer should not preclude ICU admission. Incidence, life expectancy and prognostic factors in cancer patients under prolonged mechanical ventilation: a nationwide analysis of 5138 cases during The impact of critical illness on perceived health-related quality of life during ICU treatment, ICU stay, and after ICU discharge Long-term survival, quality of life, and quality-adjusted survival in critically ill patients with cancer Quality of life after intensive care: a systemic review of the literature Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study Review on quality of life issues in patients with primary brain tumors Health-related quality of life in patients with high grade gliomas: a quantitative longitudinal study Glioblastoma and other malignant gliomas: a clinical review The 2016 world health organization classification of tumors of the central nervous system: a summary A new method of classifying prognostic comorbidity in longitudinal studies: development and validation New simplified acute physiology score (SAPS II] based on a European/North American multicenter study The SOFA (Sepsis-related Organ Failure Assessment] score to describe organ dysfunction/failure. keywords: admission; anticancer; icu; patients; performance; status; therapy; year cache: cord-012560-p5s0p7fd.txt plain text: cord-012560-p5s0p7fd.txt item: #86 of 440 id: cord-013443-x74uxdi4 author: Daniel, Dennis A. title: Pediatric Resident Engagement With an Online Critical Care Curriculum During the Intensive Care Rotation* date: 2020-06-25 words: 3161 flesch: 39 summary: ICU resident rotation directors created individualized curricula for each site that covered core concepts in pediatric critical care medicine. We did not include test attempts occurring prior to the ICU rotation in the time-of-use analysis due to the significant heterogeneity in resident clinical rotations immediately prior to the ICU rotation. keywords: attempts; curriculum; learning; residents; rotation; site; test; work cache: cord-013443-x74uxdi4.txt plain text: cord-013443-x74uxdi4.txt item: #87 of 440 id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 words: 99097 flesch: 51 summary: The application of the endotoxin activity assay was useful for bedside monitoring of endotoxemia in ICU patients. The aim of this study is to describe the clinical and epidemiological profi le of ICU patients receiving tigecycline (TGC) and to evaluate the potential benefi ts of TGC higher doses. keywords: acute; admission; adult patients; age; aim; analysis; blood; brain; cardiac; care; care patients; cases; clinical; conclusion; confi; control; criteria; critical; data; days; defi; diff; dose; early; ect; eff; emergency; erence; erent; failure; fi rst; figure; function; group; guidelines; high; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; icus; identifi; increase; infl; injury; intensive; introduction; length; levels; low; lung; management; mean; median; medical; methods; methods patients; minutes; months; mortality; n =; number; nurses; organ; outcome; p =; patients; period; post; pressure; protocol; rate; renal; response; results; risk; rst; score; sepsis; septic; severity; shock; shock patients; signifi; stay; studies; study; surgery; surgery patients; surgical; test; therapy; time; total; treatment; uid; use; ventilation; volume; years cache: cord-014464-m5n250r2.txt plain text: cord-014464-m5n250r2.txt item: #88 of 440 id: cord-014533-6qfecv5h author: Velasquez, T. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 words: 88447 flesch: 46 summary: key: cord-014533-6qfecv5h authors: Velasquez, T.; Mackey, G.; Lusk, J.; Kyle, U. G.; Fontenot, T.; Marshall, P.; Shekerdemian, L. S.; Coss-Bu, J. A.; Nishigaki, A.; Yatabe, T.; Tamura, T.; Yamashita, K.; Yokoyama, M.; Ruiz-Rodriguez, J. C.; Encina, B.; Belmonte, R.; Troncoso, I.; Tormos, P.; Riveiro, M.; Baena, J.; Sanchez, A.; Bañeras, J.; Cordón, J.; Duran, N.; Ruiz, A.; Caballero, J.; Nuvials, X.; Riera, J.; Serra, J.; Rutten, A. M. F.; van Ieperen, S. N. M.; Der Kinderen, E. P. H. M.; Van Logten, T.; Kovacikova, L.; Skrak, P.; Zahorec, M.; Kyle, U. G.; Akcan-Arikan, A.; Silva, J. C.; Mackey, G.; Lusk, J.; Goldsworthy, M.; Shekerdemian, L. S.; Coss-Bu, J. A.; Wood, D.; Harrison, D.; Parslow, R.; Davis, P.; Pappachan, J.; Goodwin, S.; Ramnarayan, P.; Chernyshuk, S.; Yemets, H.; Zhovnir, V.; Pulitano’, S. M.; De Rosa, S.; Mancino, A.; Villa, G.; Tosi, F.; Franchi, P.; Conti, G.; Patel, B.; Khine, H.; Shah, A.; Sung, D.; Singer, L.; Haghbin, S.; Inaloo, S.; Serati, Z.; Idei, M.; Nomura, T.; Yamamoto, N.; Sakai, Y.; Yoshida, T.; Matsuda, Y.; Yamaguchi, Y.; Takaki, S.; Yamaguchi, O.; Goto, T.; Longani, N.; Medar, S.; Abdel-Aal, I. R.; El Adawy, A. S.; Mohammed, H. M. E. H.; Mohamed, A. N.; Parry, S. M.; Knight, L. D.; Denehy, L.; De Morton, N.; Baldwin, C. E.; Sani, D.; Kayambu, G.; da Silva, V. Z. M.; Phongpagdi, P.; Puthucheary, Z. A.; Granger, C. L.; Rydingsward, J. E.; Horkan, C. M.; Christopher, K. B.; McWilliams, D.; Jones, C.; Reeves, E.; Atkins, G.; Snelson, C.; Aitken, L. M.; Rattray, J.; Kenardy, J.; Hull, A. M.; Ullman, A.; Le Brocque, R.; Mitchell, M.; Davis, C.; Macfarlane, B.; Azevedo, J. C.; Rocha, L. L.; De Freitas, F. F. M.; Cavalheiro, A. M.; Lucinio, N. M.; Lobato, M. S.; Ebeling, G.; Kraegpoeth, A.; Laerkner, E.; De Brito-Ashurst, I.; White, C.; Gregory, S.; Forni, L. G.; Flowers, E.; Curtis, A.; Wood, C. A.; Siu, K.; Venkatesan, K.; Muhammad, J. B. H.; Ng, L.; Seet, E.; Baptista, N.; Escoval, A.; Tomas, E.; Agrawal, R.; Mathew, R.; Varma, A.; Dima, E.; Charitidou, E.; Perivolioti, E.; Pratikaki, M.; Vrettou, C.; Giannopoulos, A.; Zakynthinos, S.; Routsi, C.; Atchade, E.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Genève, C.; Tanaka, S.; Lortat-Jacob, B.; Augustin, P.; Desmard, M.; Montravers, P.; de Molina, F. J. González; Barbadillo, S.; Alejandro, R.; Álvarez-Lerma, F.; Vallés, J.; Catalán, R. M.; Palencia, E.; Jareño, A.; Granada, R. M.; Ignacio, M. L.; Cui, N.; Liu, D.; Wang, H.; Su, L.; Qiu, H.; Li, R.; Jaffal, K.; Rouzé, A.; Poissy, J.; Sendid, B.; Nseir, S.; Paramythiotou, E.; Rizos, M.; Frantzeskaki, F.; Antoniadou, A.; Vourli, S.; Zerva, L.; Armaganidis, A.; Riera, J.; Gottlieb, J.; Greer, M.; Wiesner, O.; Martínez, M.; Acuña, M.; Rello, J.; Welte, T.; Atchade, E.; Mignot, T.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Lortat-Jacob, B.; Tanaka, S.; Augustin, P.; Desmard, M.; Montravers, P.; Soussi, S.; Dudoignon, E.; Ferry, A.; Chaussard, M.; Benyamina, M.; Alanio, A.; Touratier, S.; Chaouat, M.; Lafaurie, M.; Mimoun, M.; Mebazaa, A.; Legrand, M.; Sheils, M. A.; Patel, C.; Mohankumar, L.; Akhtar, N.; Noriega, S. K. Pacheco; Aldana, N. Navarrete; León, J. L. Ávila; Baquero, J. Durand; Bernal, F. Fernández; Ahmadnia, E.; Hadley, J. S.; Millar, M.; Hall, D.; Hewitt, H.; Yasuda, H.; Sanui, M.; Komuro, T.; Kawano, S.; Andoh, K.; Yamamoto, H.; Noda, E.; Hatakeyama, J.; Saitou, N.; Okamoto, H.; Kobayashi, A.; Takei, T.; Matsukubo, S.; Rotzel, H. B.; Lázaro, A. Serrano; Prada, D. Aguillón; Gimillo, M. Rodriguez; Barinas, O. Diaz; Cortes, M. L. Blasco; Franco, J. Ferreres; Roca, J. M. Segura; Carratalá, A.; Gonçalves, B.; Turon, R.; Mendes, A.; Miranda, F.; Mata, P. J.; Cavalcanti, D.; Melo, N.; Lacerda, P.; Kurtz, P.; Righy, C.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Romero, J. C. García; Herrera, A. N. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Hualde, J. Barado; Hernández, A. Ansotegui; Irazabal, J. M. Guergué; Spatenkova, V.; Bradac, O.; Suchomel, P.; Urli, T.; Lazzeri, E. Heusch; Aspide, R.; Zanello, M.; Perez-Borrero, L.; Garcia-Alvarez, J. M.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Rivera-Fernandez, R.; Mora-Ordoñez, J.; De La Fuente-Martos, C.; Castillo-Lorente, E.; Guerrero-Lopez, F.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Pertuz, E. D. Díaz; Hernández, A. Ansotegui; Romero, J. C. García; Sánchez, M. J. Gómez; Herrera, A. N. García; Ramírez, J. Roldán; Sanz, E. Regidor; Hualde, J. Barado; León, J. P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. L.; Pérez, H.; Calpe, P.; Alcala, M. A.; Robaglia, D.; Perez, C.; Lan, S. K.; Cunha, M. M.; Moreira, T.; Santos, F.; Lafuente, E.; Fernandes, M. J.; Silva, J. G.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Herrera, A. N. García; Romero, J. C. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Echeverría, J. G. Armando; Hernández, A. Ansotegui; Hualde, J. Barado; Podlepich, V.; Sokolova, E.; Alexandrova, E.; Lapteva, K.; Kurtz, P.; Shuinotsuka, C.; Rabello, L.; Vianna, G.; Reis, A.; Cairus, C.; Salluh, J.; Bozza, F.; Torres, J. C. Barrios; Araujo, N. J. Fernández; García-Olivares, P.; Keough, E.; Dalorzo, M.; Tang, L. K.; De Sousa, I.; Díaz, M.; Marcos-Zambrano, L. J.; Guerrero, J. E.; Gomez, S. E. Zamora; Lopez, G. D. Hernandez; Cuellar, A. I. Vazquez; Nieto, O. R. Perez; Gonzalez, J. A. Castanon; Bhasin, D.; Rai, S.; Singh, H.; Gupta, O.; Bhattal, M. K.; Sampley, S.; Sekhri, K.; Nandha, R.; Aliaga, F. A.; Olivares, F.; Appiani, F.; Farias, P.; Alberto, F.; Hernández, A.; Pons, S.; Sonneville, R.; Bouadma, L.; Neuville, M.; Mariotte, E.; Radjou, A.; Lebut, J.; Chemam, S.; Voiriot, G.; Dilly, M. P.; Mourvillier, B.; Dorent, R.; Nataf, P.; Wolff, M.; Timsit, J. F.; Ediboglu, O.; Ataman, S.; Ozkarakas, H.; Kirakli, C.; Vakalos, A.; Avramidis, V.; Obukhova, O.; Kurmukov, I. A.; Kashiya, S.; Golovnya, E.; Baikova, V. N.; Ageeva, T.; Haritydi, T.; Kulaga, E. V.; Rios-Toro, J. J.; Perez-Borrero, L.; Aguilar-Alonso, E.; Arias-Verdu, M. D.; Garcia-Alvarez, J. M.; Lopez-Caler, C.; De La Fuente-Martos, C.; Rodriguez-Fernandez, S.; Sanchez-Orézzoli, M. Gomez; Martin-Gallardo, F.; Nikhilesh, J.; Joshi, V.; Villarreal, E.; Ruiz, J.; Gordon, M.; Quinza, A.; Gimenez, J.; Piñol, M.; Castellanos, A.; Ramirez, P.; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Shah, H.; Kellner, F.; Rezai, F.; Mistry, N.; Yodice, P.; Ovnanian, V.; Fless, K.; Handler, E.; Alejos, R. Martínez; Romeu, J. D. Martí; Antón, D. González; Quinart, A.; Martí, A. 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E.; Haines, R.; Powell-Tuck, J.; Leonard, H.; Ostermann, M.; Berthelsen, R. E.; Itenov, T. S.; Perner, A.; Jensen, J. U.; Ibsen, M.; Jensen, A. E. K.; Bestle, M. H.; Bucknall, T.; Dixon, J.; Boa, F.; MacPhee, I.; Philips, B. J.; Doyle, J.; Saadat, F.; Samuels, T.; Huddart, S.; McCormick, B.; DeBrunnar, R.; Preece, J.; Swart, M.; Peden, C.; Richardson, S.; Forni, L.; Kalfon, P.; Baumstarck, K.; Estagnasie, P.; Geantot, M. A.; Berric, A.; Simon, G.; Floccard, B.; Signouret, T.; Boucekine, M.; Fromentin, M.; Nyunga, M.; Sossou, A.; Venot, M.; Robert, R.; Follin, A.; Renault, A.; Garrouste, M.; Collange, O.; Levrat, Q.; Villard, I.; Thévenin, D.; Pottecher, J.; Patrigeon, R. G.; Revel, N.; Vigne, C.; Mimoz, O.; Auquier, P.; Pawar, S.; Jacques, T.; Deshpande, K.; Pusapati, R.; Wood, B.; Pulham, R. A.; Wray, J.; Brown, K.; Pierce, C.; Nadel, S.; Ramnarayan, P.; Azevedo, J. R.; Montenegro, W. S.; Rodrigues, D. P.; Sousa, S. C.; Araujo, V. F.; Leitao, A. L.; Prazeres, P. H.; Mendonca, A. 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C.; Guérin, C.; Shinotsuka, C. Righy; Creteur, J.; Taccone, F. S.; Törnblom, S.; Nisula, S.; Vaara, S.; Poukkanen, M.; Andersson, S.; Pettilä, V.; Pesonen, E.; Xie, Z.; Liao, X.; Kang, Y.; Zhang, J.; Kubota, K.; Egi, M.; Mizobuchi, S.; Hegazy, S.; El-Keraie, A.; El Sayed, E.; El Hamid, M. Abd; Rodrigues, N. J.; Pereira, M.; Godinho, I.; Gameiro, J.; Neves, M.; Gouveia, J.; e Silva, Z. Costa; Lopes, J. A.; Mckinlay, J.; Kostalas, M.; Kooner, G.; Dudas, G.; Horton, A.; Kerr, C.; Karanjia, N.; Creagh-Brown, B.; Forni, L.; Yamazaki, A.; Ganuza, M. Sanz; Molina, J. A. Martinez; Martinez, F. Hidalgo; Freile, M. T. Chiquito; Fernandez, N. Garcia; Travieso, P. Medrano; Bandert, A.; Frithiof, R.; Lipcsey, M.; Smekal, D.; Schlaepfer, P.; Durovray, J. D.; Plouhinec, V.; Chiappa, C.; Bellomo, R.; Schneider, A. G.; Mitchell, S.; Durrant, J.; Street, H.; Dunthorne, E.; Shears, J.; Caballero, C. Hernandez; Hutchison, R.; Schwarze, S.; Ghabina, S.; Thompson, E.; Prowle, J. R.; Kirwan, C. J.; Gonzalez, C. A.; Pinto, J. L.; Orozco, V.; Patiño, J. A.; Garcia, P. K.; Contreras, K. M.; Rodriguez, P.; Echeverri, J. E. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 journal: Intensive Care Med Exp DOI: 10.1186/s40635-016-0100-7 sha: doc_id: 14533 cord_uid: 6qfecv5h nan months is better than Cole's formula. keywords: acute; admission; adult patients; age; aki; analysis; ards patients; arrest; blood; c. a.; c. c.; c. m.; cardiac; care; care patients; care unit; cases; clinical; complications; conclusions; control; criteria; data; days; death; differences; discharge; duration; end; factors; failure; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increased; infection; injury; intensive; introduction; j. a.; j. c.; j. e.; j. f.; j. g.; j. j.; j. l.; j. m.; j. p.; j. s.; length; level; lung; m. a.; m. d.; m. e.; m. m.; mean; median; medical; methods; mortality; non; number; objectives; organ; outcome; p =; patients; peep; period; post; pressure; quality; rate; results; resuscitation; risk; s. c.; s. m.; score; sepsis; septic; shock; standard; stay; study; surgery; surgical; survival; system; test; therapy; time; total; treatment; unit; use; value; ventilation; volume; weaning; y. j.; years cache: cord-014533-6qfecv5h.txt plain text: cord-014533-6qfecv5h.txt item: #89 of 440 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61107 flesch: 45 summary: We included ICU patients admitted for acute hypoxemic respiratory failure from a previous prospective trial [1] in whom FiO 2 was measured under oxygen mask using a portable oxygen analyzer. Introduction Relative adrenal insufficiency (RAI) is common in ICU patients, particularly during septic shock (1). keywords: acute; admission; adult patients; age; aim; analysis; ards patients; arrest; blood; cardiac; care; care unit; cases; cause; children; clinical; conclusion; criteria; data; days; diagnosis; discussion; disease; duration; extubation; factors; failure; fluid; group; hospital; icu; icu admission; icu mortality; icu patients; incidence; infection; injury; intensive; introduction; jean; low; lung; management; mean; mechanical; median; medical; methods; mortality; n =; niv; non; nutrition; occurrence; outcome; oxygen; p =; patients; period; pierre; pneumonia; pressure; pulmonary; rate; renal; results; risk; score; sepsis; shock; shock patients; significant; stay; studies; study; study period; support; syndrome; therapy; time; treatment; unit; use; vap; ventilation; weaning; years cache: cord-014538-6a2pviol.txt plain text: cord-014538-6a2pviol.txt item: #90 of 440 id: cord-014670-e31g8lns author: None title: Poster Sessions 313-503 date: 2004-10-05 words: 28600 flesch: 52 summary: We develop a systematic data collection of all the admitted patients in our ICU through a home-made software and database leading to a broad description of the population and activities of the ICU during the last five years; this was correlated with the classical scoring systems of ICU patients. At the first session, the participants were proposed to imagine a situation starting from one of 2 pictures of ICU patient. keywords: acute; admission; age; analysis; blood; brain; cardiac; care; data; days; dose; dysfunction; failure; fluid; group; hospital; hours; icu; injury; intensive; level; lung; mean; medical; min; mortality; non; outcome; parameters; patients; period; pressure; pts; rate; ratio; results; score; sepsis; septic; stay; study; surgery; system; therapy; treatment; unit; university; use; values; ventilation; volume cache: cord-014670-e31g8lns.txt plain text: cord-014670-e31g8lns.txt item: #91 of 440 id: cord-014987-nycbjqn6 author: None title: OP 0364-0412 date: 2006-08-24 words: 9808 flesch: 52 summary: Patients with Septic Shock also had a significantly lower oxygen consumption rate when compared to healthy volunteers or patients with SIRS (p<0.001 and p=0.002 respectively. Patients with adequate therapy were older than patients with initial inadequate antibiotic therapy (41.4±21.1 vs 60.5±16.6; p<0.01) but the APACHE II at admission was the same in both groups (21 vs 18'4; p=ns). keywords: admission; care; data; group; hospital; hours; icu; intensive; mean; medical; mortality; outcome; patients; sepsis; study; therapy; vap; ventilation cache: cord-014987-nycbjqn6.txt plain text: cord-014987-nycbjqn6.txt item: #92 of 440 id: cord-014996-p6q0f37c author: None title: Posters_Monday_12 October 2009 date: 2009-08-06 words: 85276 flesch: 51 summary: ICU patients with acute respiratory failure requiring NIV were studied during three randomized consecutive 20 min-periods of NIV: ICU ventilator with and without NIV mode and NIV ventilator. EFL was recorded in 65% of ICU patients with pulmonary diseases: 65 % of ARDS patients, 75% of patients with respiratory infection, 75% of asthmatics and 85% of patients with COPD. keywords: acute; admission; adult patients; age; aim; analysis; apache; arterial; blood; cardiac; care; care patients; conclusion; control; data; days; diagnosis; differences; duration; early; failure; fluid; group; high; hospital; hospital mortality; icu; icu admission; icu mortality; icu patients; icu stay; incidence; infection; injury; intensive; introduction; lactate; length; levels; low; lung; mean; median; medical; methods; min; model; mortality; n =; non; number; objectives; organ; outcome; oxygen; p =; parameters; patients; pct; period; pneumonia; pressure; pulmonary; rate; renal; respiratory; results; risk; score; sepsis; septic; serum; shock; shock patients; stay; study; surgery; system; test; therapy; time; total; trauma patients; treatment; unit; use; vap; ventilation; volume; years cache: cord-014996-p6q0f37c.txt plain text: cord-014996-p6q0f37c.txt item: #93 of 440 id: cord-015021-pol2qm74 author: None title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162543 flesch: 45 summary: Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases. keywords: acid; activation; activity; acute; addition; adhesion; administration; aim; analysis; animals; anti; antibodies; antibody; ards; arterial; bacteria; binding; blood; blood cells; blood levels; blood samples; body; burn; capacity; cardiac; cause; cd14; cells; cellular; challenge; changes; circulating; clinical; clp; complement; complications; concentrations; conclusion; conditions; contrast; control; control group; control patients; correlation; course; csf; cultured; cytokine levels; cytokine production; cytokines; damage; data; days; death; decrease; development; differences; disease; dose; dysfunction; effect; elevated; elisa; endothelial; endotoxin; endotoxin levels; evidence; experimental; expression; factor; failure; flow; following; formation; function; gene; gram; group; growth; gut; hepatic; high; host; hours; hrs; human; il-1; il-6; il-6 levels; il-8; ill; immune; increased; induction; infection; inflammation; inflammatory; infusion; inhibitor; injury; ischemia; leukocytes; levels; lipid; liver; lps; lung; lymphocytes; macrophages; mean; mechanisms; mediators; membrane; methods; mice; model; mof; molecules; monoclonal; monocytes; mortality; multiple; necrosis; negative; neutrophils; new; non; normal; number; operation; organ; organ failure; organ injury; outcome; oxygen; p<0.05; parameters; patients; period; peritoneal; phase; placebo; plasma; plasma levels; plasma tnf; play; pmn; positive; post; postoperative; potential; presence; present; pressure; process; production; protein; pulmonary; rate; rats; receptor; reduced; related; release; reperfusion; response; results; risk; role; saline; samples; score; sepsis; sepsis patients; septic; serum; serum levels; severity; sham; shock; sirs; soluble; specific; state; stimulation; studies; study; surface; surgery; survival; syndrome; synthesis; system; systemic; t cells; test; therapeutic; therapy; time; tissue; tnf; tnf levels; tnf production; tnf release; total; trauma patients; treated; treatment; tumor; type; use; values; vascular; vitro; vivo; wound cache: cord-015021-pol2qm74.txt plain text: cord-015021-pol2qm74.txt item: #94 of 440 id: cord-015024-2xzc0uc5 author: None title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84465 flesch: 50 summary: The primary end point of this study was to evaluate the RVD of the IVC in ICU patients with spontaneous breathing. ICU patient with spontaneous breathing and signs of hypoperfusion (oliguria, mottles, serum lactate level [2 mmol/l) were eligible after the approval of the local Ethics Committee. keywords: acute; administration; admission; age; aim; analysis; apache; baseline; blood; cardiac; care; care patients; care unit; changes; clinical; conclusions; control; critical; data; day; days; death; difference; discharge; dose; effect; factors; failure; fluid; following; function; group; hemodynamic; high; hospital; icu admission; icu patients; incidence; increase; infusion; injury; intensive; introduction; levels; low; lung; management; mean; median; medical; methods; min; months; mortality; n =; non; number; nurses; objectives; outcome; p =; parameters; patients; period; plasma; post; pressure; pulmonary; rate; response; results; resuscitation; risk; score; sepsis; septic; serum; shock; shock patients; stay; study; support; surgery; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; years cache: cord-015024-2xzc0uc5.txt plain text: cord-015024-2xzc0uc5.txt item: #95 of 440 id: cord-015061-pl5ag6zz author: None title: Editor’s picks, 2011–2012: fifteen articles in open access in Intensive Care Medicine date: 2013-10-23 words: 1484 flesch: 37 summary: Recommendations of the ESICM Working Group on Abdominal Problems Epidemiology of contrast-associated acute kidney injury in ICU patients: a retrospective cohort analysis The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study Cost-effectiveness of the Surviving Sepsis Campaign protocol for severe sepsis: a prospective nation-wide study in Spain Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease A prospective, randomized, double-blind, multicenter study comparing remifentanil with fentanyl in mechanically ventilated patients The variability of critical care bed numbers in Europe Pediatric Guidelines Sub-Committee for the World Society of the Abdominal Compartment Syndrome. [1] We invite you to read a very interesting study that establishes antibioresistance and genotypic characteristics of E. coli isolates isolated from VAP in adult ICU patients. keywords: care; icu; patients; sepsis; study cache: cord-015061-pl5ag6zz.txt plain text: cord-015061-pl5ag6zz.txt item: #96 of 440 id: cord-015082-l629n8is author: None title: Poster Sessions 323-461 date: 2002-08-29 words: 26609 flesch: 50 summary: Isoflurane sedation of ICU patients has previously been shown to be useful but has not come into wide clinical use for a number of reasons. Isoflurane administered via the ACD for sedation of ICU patients is environmentally safe, requires small volumes of isoflurane and may provide better quality of sedation than midazolam. keywords: acute; admission; age; analysis; blood; cardiac; care; complications; control; data; days; effect; group; hospital; hours; icu; increase; injury; levels; mean; methods; min; mortality; outcome; patients; postoperative; pressure; protein; rate; rats; response; results; score; sepsis; septic; shock; stay; study; surgery; test; time; trauma; treatment; years cache: cord-015082-l629n8is.txt plain text: cord-015082-l629n8is.txt item: #97 of 440 id: cord-015090-n6f4xupw author: None title: PS 339-563 date: 2005-09-10 words: 26303 flesch: 51 summary: Propofol is often used as a sedative in ICU patients. The aim of this study was to suggest how the computation of ÄSID should be sophisticated in order to obtain a good correspondence with BE in ICU patients. keywords: admission; age; aim; analysis; blood; brain; cardiac; care; cases; changes; conclusion; costs; data; days; group; hospital; hours; icu; intensive; levels; mean; medical; methods; mortality; non; organ; outcome; patients; period; pressure; rate; risk; score; sepsis; shock; stay; study; surgery; test; time; trauma; tube; unit; university; use; ventilation cache: cord-015090-n6f4xupw.txt plain text: cord-015090-n6f4xupw.txt item: #98 of 440 id: cord-015126-cyhcbk1j author: None title: PS 0036-0344 date: 2007-08-25 words: 59258 flesch: 52 summary: The aim of this clinical trial is to study CIP in ICU patients (pts) after surgical procedures. The physiological condition of ICU patients is marked by rapidly evolving and frequently life-threatening derangements as well as 'silent' yet important alterations in homeostasis. keywords: acute; admission; age; aim; analysis; apache; arterial; baseline; blood; care; cases; changes; conclusion; control; data; days; disease; early; effects; end; factors; failure; fio2; flow; fluid; glucose; group; high; hospital; hours; icu; icu patients; increase; index; infection; infusion; injury; intensive; level; lung; mean; median; medical; min; model; mortality; non; outcome; parameters; patients; period; pressure; pts; rate; respiratory; results; risk; score; sepsis; septic; shock; shock patients; stay; study; support; surgery; system; test; therapy; time; total; trauma; treatment; unit; use; values; ventilation; volume; years cache: cord-015126-cyhcbk1j.txt plain text: cord-015126-cyhcbk1j.txt item: #99 of 440 id: cord-015372-76xvzvdg author: None title: National scientific medical meeting 1996 abstracts date: 1996 words: 36628 flesch: 50 summary: Control patients were enrolled who had no clinical evidence of rheumatological disease, A salivary sample was collected and examined by light microscopy. Drug induced photosensitivity may look identical clinically, have a similar history and patients with CAD may be treated with potentially photosensitising drugs. keywords: acid; activity; age; aim; analysis; antibodies; blood; bone; care; cases; cells; children; controls; data; day; difference; disease; drug; expression; females; findings; following; group; hiv; hospital; incidence; increase; infection; irish; levels; males; mean; months; negative; number; pain; patients; pcr; period; population; positive; present; range; rate; response; results; risk; samples; serum; skin; studies; study; subjects; test; therapy; time; total; treatment; type; use; virus; years cache: cord-015372-76xvzvdg.txt plain text: cord-015372-76xvzvdg.txt item: #100 of 440 id: cord-015640-zdwmxaz3 author: Tong, C. Y. W. title: Clinical Virology in NICU, PICU and AICU date: 2011-08-10 words: 6055 flesch: 39 summary: Clinically, influenza infection is characterised by abrupt onset of fever, sore throat, myalgia, cough, headache and malaise. key: cord-015640-zdwmxaz3 authors: Tong, C. Y. W.; Schelenz, S. title: Clinical Virology in NICU, PICU and AICU date: 2011-08-10 journal: Infection Control in the Intensive Care Unit DOI: 10.1007/978-88-470-1601-9_20 sha: doc_id: 15640 cord_uid: zdwmxaz3 Viruses are significant causes of nosocomial infections, particularly in intensive care unit (ICU) where seriously ill and vulnerable patients are being cared for. keywords: care; control; diagnosis; disease; health; icu; infection; influenza; patients; risk; rsv; transmission; virus; workers cache: cord-015640-zdwmxaz3.txt plain text: cord-015640-zdwmxaz3.txt item: #101 of 440 id: cord-016109-vbzy11hc author: Damjanovic, V. title: Outbreaks of Infection in the ICU: What’s up at the Beginning of the Twenty-First Century? date: 2011-08-10 words: 5497 flesch: 45 summary: Two reports described ICU outbreaks caused by Hansenula anomala, an opportunistic yeast first reported from a Liverpool, UK, NICU in 1986 In conclusion, new trends as well as old confirm what we indicated in the previous edition of this book, which is that to control and prevent ICU outbreaks, surveillance cultures and SDD should be integrated in routine infection-control measures. keywords: authors; care; control; icu; infection; outbreak; patients; surveillance; unit; vancomycin cache: cord-016109-vbzy11hc.txt plain text: cord-016109-vbzy11hc.txt item: #102 of 440 id: cord-016208-u12ngkpc author: Andersen, Bjørg Marit title: Intensive Patient Treatment date: 2018-09-25 words: 4582 flesch: 47 summary: Intensive patients are treated with extensive invasive procedures, which may cause a risk of hospital infections in 10–30% of the cases. Use sterile water for intensive care patients for oral hygiene. keywords: bacteria; care; control; hospital; hygiene; icu; infections; patients; room; unit; use cache: cord-016208-u12ngkpc.txt plain text: cord-016208-u12ngkpc.txt item: #103 of 440 id: cord-016498-j72vrvqf author: Fong, I. W. title: Issues in Community-Acquired Pneumonia date: 2020-03-07 words: 8292 flesch: 36 summary: Moreover, neutrophils from severe CAP patients showed reduced respiratory burst activity compared to the non-severe group. In a prospective multicenter cohort study of 4070 hospitalized CAP patients, 37.6% presented with severe sepsis [42] . keywords: adults; analysis; cap; children; community; mortality; patients; pneumonia; respiratory; review; risk; studies; study; treatment cache: cord-016498-j72vrvqf.txt plain text: cord-016498-j72vrvqf.txt item: #104 of 440 id: cord-017227-66dx2dkv author: Humphreys, Hilary title: Immunocompromised Patients date: 2012-08-21 words: 4903 flesch: 33 summary: Clearly, the change in prognosis of HIV with HAART has led to a shift in management such that HIV patients are offered maximal treatment, including full ICU support, organ transplantation in the appropriate circumstances, or chemotherapy if needed. A thorough discussion of the management of HIV patients is beyond the scope of this book. keywords: aspergillosis; cancer; disease; hiv; icu; infection; neutrophil; patients; pcp; transplantation; treatment cache: cord-017227-66dx2dkv.txt plain text: cord-017227-66dx2dkv.txt item: #105 of 440 id: cord-017302-xez0zso3 author: Stephens, R. Scott title: ICU Complications of Hematopoietic Stem Cell Transplant, Including Graft vs Host Disease date: 2019-07-24 words: 5227 flesch: 28 summary: National Institute of Allergy and Infectious Diseases Mycoses Study Group Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia Neutropenic enterocolitis: new insights into a deadly entity The prognostic impact of abdominal surgery in cancer patients with neutropenic enterocolitis: a systematic review and meta-analysis, on behalf the Groupe de Recherche en Reanimation Respiratoire du patient d'Onco-Hematologie (GRRR-OH) Acute respiratory distress syndrome in patients with malignancies Acute respiratory distress syndrome during neutropenia recovery Pulmonary complications of bone marrow transplantation Outcomes of stem cell transplant patients with acute respiratory failure requiring mechanical ventilation in the United States Epidemiology of acute respiratory distress syndrome following hematopoietic stem cell transplantation Pulmonary infections complicating hematological disorders Febrile neutropenia: significance of elaborated screening for respiratory viruses, and the comparison of different sampling methods, in neutropenic patients with hematological malignancies Viral pneumonia in patients with hematologic malignancy or hematopoietic stem cell transplantation Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients BCSH/BSBMT/UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation Management of RSV infections in adult recipients of hematopoietic stem cell transplantation Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Fungal pneumonia in patients with hematologic malignancy and hematopoietic stem cell transplantation Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Neuromuscular blockers in early acute respiratory distress syndrome Prone positioning in severe acute respiratory distress syndrome Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure The Intensive Care Medicine research agenda on critically ill oncology and hematology patients Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume Noninvasive ventilation during acute respiratory distress syndrome in patients with cancer: trends in use and outcome Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial Acute respiratory failure in patients with hematological malignancies: outcomes according to initial ventilation strategy. Refinement of transplant techniques over the last 2 decades has dramatically decreased transplant-related mortality, but approximately 15% of HSCT patients require critical care keywords: acute; allogeneic; cell; failure; gvhd; hematopoietic; hsct; mortality; patients; stem; syndrome; transplant; transplantation cache: cord-017302-xez0zso3.txt plain text: cord-017302-xez0zso3.txt item: #106 of 440 id: cord-017489-ftz9190a author: Richards, Guy A. title: Viruses in the Intensive Care Unit (ICU) date: 2005 words: 5796 flesch: 37 summary: -2 % from 15-30% if initiated within the first 8 days of illness (12) and is also possibly of value in Lassa virus infection (13). Porterfield JS Clinical Practice and Public Health Control Virus induced endothelial permeability triggered by affected macrophages Hemostasis and the complement system in Argentine hemorrhagic fever Cardiovascular and pulmonary responses to Pichinde virus infection in strain 13 guinea pigs A nosocomial outbreak of Crimean-Congo hemorrhagic fever at Tyberberg Hospital (part II). keywords: cytomegalovirus; days; disease; fever; hepatitis; infection; mortality; patients; pneumonia; therapy; treatment; varicella; viral; virus cache: cord-017489-ftz9190a.txt plain text: cord-017489-ftz9190a.txt item: #107 of 440 id: cord-017518-u2gsa4lg author: Divatia, J. V. title: Nosocomial Infections and Ventilator-Associated Pneumonia in Cancer Patients date: 2019-07-09 words: 8769 flesch: 28 summary: The impact of hospitalacquired infections with multidrug-resistant bacteria in an oncology intensive care unit Hospital-acquired infections at an oncological intensive care cancer unit: differences between solid and hematological cancer patients Ventilator-associated pneumonia (VAP) -early and late-onset differences Evaluation of the 2016 Infectious Diseases Society of America/American Thoracic Society guideline criteria for risk of multidrug-resistant pathogens in patients with hospital-acquired and ventilator-associated pneumonia in the ICU Benchmarking local healthcare-associated infections: available benchmarks and interpretation challenges CDC definitions for nosocomial infections The epidemiology of nonventilator hospital-acquired pneumonia in the United States Microbial profile of early and late onset ventilator associated pneumonia in the intensive care unit of a tertiary care hospital in Bangalore, India Colistin for lung infection: an update Management of nosocomial pneumonia on a medical ward: a comparative study of outcomes and costs of invasive procedures Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the Infectious Diseases Society of America Ventilator associated pneumonia Respective impact of implementation of prevention strategies, colonization with multiresistant bacteria and antimicrobial use on the risk of early-and late-onset VAP: an analysis of the OUTCOMEREA network Institute for healthcare improvement: how-to guide: prevent ventilator-associated pneumonia Institute for Healthcare Improvement: Evidence-Based Care Bundles n.d Institute For Healthcare Improvement, I. Institute for healthcare improvement: how-to guide: prevent ventilator-Associated pneumonia Defining antibiotic dosing in lung infections Trends in antibiotic use and nosocomial pathogens in hospitalized veterans with pneumonia at 128 medical centers Empirical antibiotic therapy for ventilator-associated pneumonia Ventilator-associated pneumonia in the ICU Management of Adults with hospitalacquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society Nosocomial infections and their control strategies Nosocomial infections: epidemiology, prevention, control and surveillance Severe sepsis bundles Prevalence of and risk factors for hospital-acquired infections in Slovenia-results of the first national survey The prevalence of and risk factors for healthcare-associated infections in Slovenia: results of the second national survey. Nosocomial infections or hospital-acquired infections (HAIs) are defined by the Centers for Disease Control and Prevention (CDC) as those infections that were not present in carrier state or incubating state at the time of admission and manifest 48 h after hospital admission [24] . keywords: antibiotic; care; clinical; control; days; guidelines; hospital; infections; patients; pneumonia; rates; risk; tract; treatment; use; vap; ventilator cache: cord-017518-u2gsa4lg.txt plain text: cord-017518-u2gsa4lg.txt item: #108 of 440 id: cord-017771-g72qaoub author: Lohan, Rahul title: Imaging of ICU Patients date: 2019-01-15 words: 3759 flesch: 37 summary: The diagnosis of pneumonia in ICU patients is often challenging as the airspace opacities seen on chest radiographs in these patients can be caused by atelectasis, aspiration, pulmonary hemorrhage, noninfectious lung inflammation (e.g., drug reaction), pulmonary edema, or ARDS The common pulmonary parenchymal disease processes in ICU patients include hydrostatic pulmonary edema, acute respiratory distress syndrome (ARDS), atelectasis, pneumonia, aspiration, and pulmonary hemorrhage. keywords: chest; edema; fig; icu; imaging; patients; pulmonary; tube cache: cord-017771-g72qaoub.txt plain text: cord-017771-g72qaoub.txt item: #109 of 440 id: cord-017772-zpf1xjqi author: Walter, James M. title: Thrombocytopenia in the Intensive Care Unit date: 2019-07-24 words: 4581 flesch: 37 summary: In general, ICU patients who develop thrombocytopenia are sicker than patients with normal platelet counts, with higher illness severity scores, more need for vasoactive infusions, and more organ dysfunction [8, 9] . On behalf of the working group on Sepsis-related problems of the European Society of Intensive Care Medicine Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study Pseudothrombocytopenia due to platelet clumping: a case report and brief review of the literature Bleeding and coagulopathies in critical care Guidelines for the use of platelet transfusions Evidence-based platelet transfusion guidelines Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies Syndromes of thrombotic microangiopathy Thrombotic thrombocytopenic purpura Thrombotic thrombocytopenic purpura The incidence of thrombotic thrombocytopenic purpurahemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015 Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. keywords: cells; count; dic; heparin; hit; patients; platelet; sepsis; thrombocytopenia cache: cord-017772-zpf1xjqi.txt plain text: cord-017772-zpf1xjqi.txt item: #110 of 440 id: cord-018005-53cl75gk author: Humphreys, Hilary title: Lower Respiratory Tract Infections date: 2012-08-21 words: 3865 flesch: 34 summary: Plain radiographs of adequate diagnostic quality are often dif fi cult to obtain in critical care patients and CT scanning is often required to make a radiological diagnosis which should be supplemented with microbiological samples to con fi rm the aetiology [ 30 ] . All units admitting such patients should have local protocols and training in place to offer NIV to patients presenting in respiratory failure in the context of COPD. keywords: cap; care; copd; icu; intensive; mortality; patients; pneumonia cache: cord-018005-53cl75gk.txt plain text: cord-018005-53cl75gk.txt item: #111 of 440 id: cord-018182-lleti89n author: Kassutto, Stacey M. title: Care of the Surgical ICU Patient with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension date: 2016-10-09 words: 6227 flesch: 29 summary: These exacerbations carry a significant risk to patients, with 10 % in-hospital mortality and 1-year and 2-year all-cause mortality rates of 43 % and 49 %, respectively, in patients with hypercapnic exacerbations [3]. Given that patients transferred to the ICU with AECOPD are at high risk for complications and adverse outcomes, early diagnosis and management are critical to improve patient outcomes and survival in this population. keywords: acute; aecopd; chronic; disease; exacerbations; failure; icu; management; patients; pressure; ventilation cache: cord-018182-lleti89n.txt plain text: cord-018182-lleti89n.txt item: #112 of 440 id: cord-018412-kv3vxmcw author: Bambi, Stefano title: Evolution of Intensive Care Unit Nursing date: 2017-10-06 words: 8547 flesch: 40 summary: The main lines of discussion in critical care nursing research should include nursing research priorities in critical care patients, holistic approaches to the patient, the humanization of care, special populations of ICU patients, and challenges related to critical care nursing during emerging outbreaks of infectious diseases. When ICU nurses were surveyed in regard to the elements that provided them with work satisfaction, they responded that the main elements were related to nursing unit management; the relationships with and the organization of medical staff; rostering practices; nurses roles in ICU patient care; and general relationships in the workplace [28] . keywords: care; environment; healthcare; hospital; icu; management; nurses; nursing; outcomes; patients; research; risk; staff; strategies; support; team; work; years cache: cord-018412-kv3vxmcw.txt plain text: cord-018412-kv3vxmcw.txt item: #113 of 440 id: cord-018801-amet0wx4 author: Park, Caroline title: Care of the Patient with Liver Failure Requiring Transplantation date: 2018-05-04 words: 4708 flesch: 28 summary: Liver transplant patients may be eligible for fast-track extubation immediately postoperative in the operating room and upon arrival to the ICU. Liver transplant patients with hemorrhage that are undergoing appropriate blood product resuscitation and become hemodynamically unstable or develop abdominal compartment syndrome should return immediately to the operating room. keywords: acute; biliary; care; failure; graft; icu; liver; patients; risk; transplantation; treatment cache: cord-018801-amet0wx4.txt plain text: cord-018801-amet0wx4.txt item: #114 of 440 id: cord-019043-cqmqwl3i author: Fidalgo, Pedro title: Chronic Kidney Disease in the Intensive Care Unit date: 2014-03-08 words: 8679 flesch: 26 summary: • CKD patients have a high prevalence of comorbid disease compared to non-CKD patients; however, CKD patients have reasonable short-term outcomes following ICU admission compared to non-CKD patients. The most common diagnoses contributing to ICU admission in CKD patients are sepsis and septic shock and decompensated cardiovascular disease. keywords: acute; aki; ckd; disease; esrd; esrd patients; fluid; icu; illness; kidney; mortality; patients; risk; rrt; sepsis; support; therapy cache: cord-019043-cqmqwl3i.txt plain text: cord-019043-cqmqwl3i.txt item: #115 of 440 id: cord-021917-z9wpjr0d author: Stephens, R. Scott title: Bioterrorism and the Intensive Care Unit date: 2009-05-15 words: 8262 flesch: 42 summary: Finally, other patients in the ICU are immunocompromised by virtue of their own critical illnesses, notwithstanding the disproportionate number of ICU patients who are immunosuppressed secondary to organ transplantation, oncologic conditions, or infection with the human immunodeficiency virus (HIV). Hands must be washed after each patient contact even when protective gloves are used because a surprisingly high percentage of protective gloves contain microscopic holes, and holes may develop during the activities of routine patient care. keywords: agents; anthrax; care; days; disease; equipment; event; exposure; health; medical; patients; plague; smallpox; victims cache: cord-021917-z9wpjr0d.txt plain text: cord-021917-z9wpjr0d.txt item: #116 of 440 id: cord-022501-9wnmdvg5 author: None title: P1460 – P1884 date: 2015-12-28 words: 128422 flesch: 46 summary: In the first half-year of 2005 family doctors most often prescribed penicyllins -(44.8%), makrolids -(27.1%), cephalosporins -(12.5%), tetracyclins -(9.4%) and lincozamidsbased (3.1%) treatments Specialist doctors, on the other hand, prescribed penicllins (41.7%), makrolids (17.9%), cephalosporins (17.7%), tetracyclins (12.1%), lincozamids (5.2%) and chinolons (3%). State-wide antibiotic consumption in the AC setting during the same time was 12 DID (~85% of total consumption). keywords: acid; activity; acute; aeruginosa; agar; age; agents; aim; analysis; antibiotic; antimicrobial; assay; aureus; bacteria; beta; blood; care; cases; cause; cfu; children; ciprofloxacin; clinical; coli; common; community; concentrations; conclusion; consumption; control; cost; culture; daily; data; days; detection; diagnosis; diarrhoea; differences; different; difficile; disease; distribution; dna; dose; drug; duration; effect; efficacy; erythromycin; factors; faecium; following; frequency; gene; gram; group; guidelines; health; hospital; hours; human; identification; imipenem; incidence; increase; infections; information; isolates; laboratory; level; levofloxacin; linezolid; mean; medical; meningitis; methicillin; methods; mic; mics; model; months; mortality; moxifloxacin; mrsa; n =; negative; new; non; number; objectives; pathogens; patients; pcr; penicillin; period; phenotype; pneumoniae; population; positive; presence; prevalence; protein; range; rates; resistance; respiratory; results; risk; s. aureus; samples; sequence; sequencing; serum; skin; species; specific; specimens; spectrum; spp; standard; staphylococcus; strains; streptococcus; studies; study; subjects; susceptibility; susceptible; test; tetracycline; therapy; tigecycline; time; tissue; total; toxin; tract; treatment; type; use; values; vancomycin; vitro; years cache: cord-022501-9wnmdvg5.txt plain text: cord-022501-9wnmdvg5.txt item: #117 of 440 id: cord-022633-fr55uod6 author: None title: SAEM Abstracts, Plenary Session date: 2012-04-26 words: 147610 flesch: 49 summary: Objectives: To identify the prevalence of NCS and other EEG abnormalities in ED patients with AMS. Objectives: Test the hypothesis that prior to antibiotic administration, circulating LPS can be detected in the plasma of fewer than 10% of ED patients with severe sepsis. keywords: academic; acute; admission; adult ed; adult patients; age; analysis; arrest; arrest patients; assessment; association; average; background; blood; cardiac; care; cases; center; change; characteristics; chest; children; clinical; cohort; conclusion; confidence; control; cpr; criteria; data; days; department; diagnosis; difference; discharge; disease; ed care; ed patients; ed physicians; ed visits; eds; effect; emergency; emergency department; ems; evaluation; factors; following; group; health; high; hospital; hospital ed; hours; implementation; increase; information; initial; injury; inpatient; intervention; intubation; length; level; los; low; management; mean; median; medical; medicine; methods; minutes; model; months; mortality; n =; non; number; objectives; outcomes; overall; p =; pain; pain patients; participants; pediatric; performance; period; population; post; pre; prehospital; primary; prior; program; protocol; providers; quality; range; rate; regression; research; residency; residents; respectively; results; retrospective; review; risk; sample; score; screening; self; sepsis; setting; shock; standard; students; studies; study; study ed; subjects; survey; survival; system; table; test; testing; time; total; training; trauma patients; treatment; triage; urban; use; years cache: cord-022633-fr55uod6.txt plain text: cord-022633-fr55uod6.txt item: #118 of 440 id: cord-023592-w96h4rir author: None title: Abstracts cont. date: 2015-12-28 words: 67976 flesch: 48 summary: The maximum amino acid identities of genes among different non-antibiotic-producing bacterial isolates were close to 100% for most genes, but those between antibiotic-producing and human or animal bacteria ranged from <28 to <77%. Results: Seven or eight participants provided qualifying results in the two separate QC studies, and the calculated (proposed) ranges were (range; % results in range): E. faecalis ATCC 29212 (2-8 mg/ L; 95.6), S. aureus ATCC 29213 (0.5-2 mg/L; 99.4), S. pneumoniae ATCC 49619 (0.25-1 mg/L; 97.5 and 30-37 mm; 97.6), H. influenzae ATCC 49247 (1-4 mg/L; 97.5 and 24-32 mm; 99.8), and S. aureus ATCC 25923 keywords: activity; aeruginosa; agar; agents; aim; analysis; antibiotic; antimicrobial; aureus; bacterial; beta; blood; candida; cases; catheter; cfu; ciprofloxacin; clinical; coli; conclusions; control; culture; data; days; detection; dna; esbl; faecium; genes; gram; group; hospital; human; identification; infection; isolates; lactamase; methods; mic; mice; mics; mortality; mrsa; nccls; negative; new; non; number; objectives; pathogens; patients; pcr; period; pfge; pneumoniae; positive; presence; prevalence; producing; production; pylori; range; resistance; results; salmonella; samples; sequence; species; specific; specimens; spp; strains; study; susceptibility; system; tested; tests; therapy; time; total; toxin; treatment; type; vancomycin; years cache: cord-023592-w96h4rir.txt plain text: cord-023592-w96h4rir.txt item: #119 of 440 id: cord-023669-3ataw6gy author: Masur, Henry title: Critically Ill Immunosuppressed Host date: 2009-05-15 words: 11198 flesch: 30 summary: HIV patients pose a risk to health care professionals, however. For such patients, mucormycosis and non-albicans Candida are becoming more prominent causes of morbidity. keywords: cd4; ciency; cmv; diagnosis; disease; drugs; empiric; hiv; immunodefi; infection; lymphocyte; neutropenia; organ; patients; pneumonia; risk; specifi; therapy cache: cord-023669-3ataw6gy.txt plain text: cord-023669-3ataw6gy.txt item: #120 of 440 id: cord-023873-fidpskcs author: Meersseman, Wouter title: Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient date: 2009-05-04 words: 4145 flesch: 37 summary: A summary of available studies in ICU patients is listed in Table 1 In other groups, including ICU patients, similar CT-findings are frequently absent and, if present, are far less specific [4] . keywords: aspergillosis; aspergillus; diagnosis; galactomannan; icu; lung; patients; risk cache: cord-023873-fidpskcs.txt plain text: cord-023873-fidpskcs.txt item: #121 of 440 id: cord-025164-hqj22yxe author: Renew, J. Ross title: Neuromuscular blockade management in the critically Ill patient date: 2020-05-24 words: 8196 flesch: 27 summary: Management of the airway of ICU patients presents multiple and varied challenges, as it is one of the most commonly performed procedures in this setting. Despite the availability of indicators of difficult airway in ICU patients, however, a recent French survey found that 43% of intubating operators were still not fully proficient in the technique, with 18.8% of them having had no intubation training, or only basic training, such as lectures or observation keywords: airway; blockade; blocking; care; guidelines; icu; intensive; intubation; management; nmbas; patients; risk; rocuronium; setting; use cache: cord-025164-hqj22yxe.txt plain text: cord-025164-hqj22yxe.txt item: #122 of 440 id: cord-025749-mip9mkef author: Jo, Sungyang title: Newly developed stroke in patients admitted to non-neurological intensive care units date: 2020-06-02 words: 4137 flesch: 41 summary: We defined stroke according to the findings on CT and/or MRI images of the brain, but only 22% of ICU patients underwent such neuroimaging studies, so patients who developed stroke but did not undergo neuroimaging studies, due to very unstable vital signs and early death soon after admission to the ICU, may not have been identified as having IOS. Patients with altered mental status as an initial stroke manifestation had time delays to the stroke recognition than patients without altered mental status (p = 0.027), while patients with seizure as an initial stroke manifestation had shorter time intervals for the stroke recognition than patients without seizure (p = 0.047). keywords: icu; ios; ischemic; mortality; patients; stroke; time cache: cord-025749-mip9mkef.txt plain text: cord-025749-mip9mkef.txt item: #123 of 440 id: cord-025861-nsrs6dmc author: Waldeck, Frederike title: Influenza-associated aspergillosis in critically-ill patients—a retrospective bicentric cohort study date: 2020-06-03 words: 3993 flesch: 40 summary: Organ supportive therapies and complications were more frequent in IAA patients than in non-IAA patients ( Table 2 in the Appendix). The length of stay in the ICU was significantly elevated in IAA patients (Fig. 2) . keywords: aspergillosis; aspergillus; days; iaa; icu; influenza; patients; study cache: cord-025861-nsrs6dmc.txt plain text: cord-025861-nsrs6dmc.txt item: #124 of 440 id: cord-026392-cvb44v5v author: Dahlberg, Jørgen title: Barriers and challenges in the process of including critically ill patients in clinical studies date: 2020-06-08 words: 4783 flesch: 47 summary: Our study revealed that 38% of patient consents were oral, even though study investigators tried to obtain written consent whenever possible. Evaluating patient capacity in practice Informed consent during the clinical emergency of acute myocardial infarction (HERO-2 consent substudy): a prospective observational study Informed consent in clinical trials in critical care: experience from the PAC-man study An ethical analysis of proxy and waiver of consent in critical care research European legislation impedes critical care research and fails to protect patients' rights Confronting the ethical challenges to informed consent in emergency medicine research Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results Research without informed patient consent in incompetent patients keywords: care; challenges; consent; kin; patients; research; study cache: cord-026392-cvb44v5v.txt plain text: cord-026392-cvb44v5v.txt item: #125 of 440 id: cord-027678-k64whepc author: Chan, Kai Man title: Pneumonia date: 2020-06-22 words: 6629 flesch: 35 summary: The role of PCR in diagnosing PCP is mainly limited to non-HIV patients, in whom conventional microscopy and staining of induced sputum and BAL have a lower sensitivity than in HIV patients. The pattern of TB in HIV patients coughs up material containing cysts and trophozoites. keywords: days; diagnosis; disease; guidelines; hiv; icu; infection; management; organisms; patients; pneumonia; sputum; treatment cache: cord-027678-k64whepc.txt plain text: cord-027678-k64whepc.txt item: #126 of 440 id: cord-027811-vk3qnumx author: Freedberg, Daniel E. title: Impact of Fiber-Based Enteral Nutrition on the Gut Microbiome of ICU Patients Receiving Broad-Spectrum Antibiotics: A Randomized Pilot Trial date: 2020-06-11 words: 3843 flesch: 45 summary: Enteral fiber was associated with nonsignificant trends toward increased relative abundance of short-chain fatty acid–producing bacteria and increased short-chain fatty acid levels among ICU patients receiving broad-spectrum IV antibiotics. All observations were intent-totreat and there was a 20% rate of crossover, a common challenge for ICU nutrition studies (19) . keywords: day; fiber; group; icu; nutrition; patients; scfa; stool; study cache: cord-027811-vk3qnumx.txt plain text: cord-027811-vk3qnumx.txt item: #127 of 440 id: cord-028164-yn53209z author: Abe, Toshikazu title: Epidemiology of sepsis and septic shock in intensive care units between sepsis-2 and sepsis-3 populations: sepsis prognostication in intensive care unit and emergency room (SPICE-ICU) date: 2020-06-30 words: 3095 flesch: 50 summary: Table 1 shows characteristics of patients with infection in ICUs according to sepsis definitions. The trend in pathogens and antibiotics according to sepsis definitions was also nonspecific; however, blood culture positivity was lower if patients did not meet any definitions (sepsis-2 or sepsis-3), and carbapenem was more frequently used in patients who met any definitions (Table 2) . keywords: data; definitions; infection; mortality; patients; sepsis-3; study cache: cord-028164-yn53209z.txt plain text: cord-028164-yn53209z.txt item: #128 of 440 id: cord-028639-mk798t8f author: Weeden, M. title: Functional Outcomes in Patients Admitted to the Intensive Care Unit with Traumatic Brain Injury and Exposed to Hyperoxia: A Retrospective Multicentre Cohort Study date: 2020-07-06 words: 3742 flesch: 45 summary: Our study is unique in its investigation of long-term functional outcomes in a large cohort of TBI patients. Given the lack of high-quality data to guide practice otherwise, our results imply that rigorous clinical avoidance of hyperoxia in TBI patients may not be necessary, and should reinforce clinical equipoise for future randomized controlled trials in this area. keywords: data; hyperoxia; icu; injury; oxygen; patients; study; tbi cache: cord-028639-mk798t8f.txt plain text: cord-028639-mk798t8f.txt item: #129 of 440 id: cord-028923-gzqd5g0k author: Vitug, Sarah title: Sedation with ketamine and fentanyl combination improves patient outcomes in intensive care units date: 2020-07-10 words: 1068 flesch: 25 summary: We acknowledge that even lowdose ketamine and supplementary analgesic/sedative agents can precipitate unwanted medication-induced psychotic symptoms and other side effects; thus, continued close monitoring of postoperative ICU patients under this multimodal regimen is advised. key: cord-028923-gzqd5g0k authors: Vitug, Sarah; Ravi, Vikas; Thangathurai, Duraiyah title: Sedation with ketamine and fentanyl combination improves patient outcomes in intensive care units date: 2020-07-10 journal: SN Compr Clin Med DOI: 10.1007/s42399-020-00275-3 sha: doc_id: 28923 cord_uid: gzqd5g0k Psychological manifestations such as depression and suicidal ideation are commonly caused by poorly controlled pain, anxiety, and sleep deprivation in intensive care unit (ICU) patients. keywords: ketamine; patients; sedation cache: cord-028923-gzqd5g0k.txt plain text: cord-028923-gzqd5g0k.txt item: #130 of 440 id: cord-029429-egoso04w author: Sinha, Vikas title: Bedside Tracheostomy: Our Experience in a Tertiary Care Hospital date: 2020-07-20 words: 2082 flesch: 57 summary: [12] stated that out of fear of transporting ill patients tracheostomies were less frequently used in the past. Study consists of 200 patients who underwent bedside tracheostomies in a tertiary care center from 2014 to 2017 in medical/surgical/paediatric ICU’s. keywords: bedside; patients; procedure; study; tracheostomy cache: cord-029429-egoso04w.txt plain text: cord-029429-egoso04w.txt item: #131 of 440 id: cord-029516-tj93wo1s author: Chelly, Jonathan title: Automated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING) date: 2020-07-22 words: 4414 flesch: 42 summary: IOSR JNHS Safety and efficacy of a fully closed-loop control ventilation (IntelliVent-ASV(R)) in sedated ICU patients with acute respiratory failure: a prospective randomized crossover study Evaluation of fully automated ventilation: a randomized controlled study in post-cardiac surgery patients Prospective randomized crossover study of a new closed-loop control system versus pressure support during weaning from mechanical ventilation Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients Feasibility study on full closed-loop control ventilation (IntelliVent-ASV) in ICU patients with acute respiratory failure: a prospective observational comparative study Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial of ventilation delivered Closed loop ventilation mode in intensive care unit: a randomized controlled clinical trial comparing the numbers of manual ventilator setting changes Airway and transpulmonary driving pressures and mechanical powers selected by INTELLiVENT-ASV in passive, mechanically ventilated ICU patients Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial British Thoracic Society Guideline for oxygen use in adults in healthcare and emergency settings Positional hypoxemia during artificial ventilation Lateral positioning of ventilated intensive care patients: a study of oxygenation, respiratory mechanics, hemodynamics, and adverse events Effects of patients positioning on respiratory mechanics in mechanically ventilated ICU patients The effect of patient positioning on dynamic lung compliance Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury A meta-analysis of the effects of various interventions in preventing endotracheal suction-induced hypoxemia Changes in lung volume with three systems of endotracheal suctioning with and without pre-oxygenation in patients with mild-to-moderate lung failure Ventilator-related causes of lung injury: the mechanical power Comparative evaluation of accuracy of pulse oximeters and factors affecting their performance in a tertiary intensive care unit Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations We are indebted to Caroline Huber-Brown for editorial assistance. 2 Comparison between conventional and automated ventilation in terms of minimal, mean, and maximal blood oxygen saturation (SpO 2 ) during daily nursing procedures (*p < 0.05) Creating the animated intensive care unit Strategies for post ICU rehabilitation Body positioning of intensive care patients: clinical practice versus standards A prospective observational study of ICU patient position and frequency of turning Increased splanchnic oxygen extraction because of routine nursing procedures Body position change and its effect on hemodynamic and metabolic status Secondary insults related to nursing interventions in neurointensive care: a descriptive pilot study The effect of nursing interventions on the intracranial pressure in paediatric traumatic brain injury Decreasing severe pain and serious adverse events while moving intensive care unit patients: a prospective interventional study (the NURSE-DO project) Physiological changes associated with routine nursing procedures in critically ill are common: an observational pilot study Daily nursing care on patients undergoing venous-venous extracorporeal membrane oxygenation: a challenging procedure Oxygen desaturation and nursing practices in critically ill patients. keywords: blood; desaturation; dnps; oxygen; patients; spo cache: cord-029516-tj93wo1s.txt plain text: cord-029516-tj93wo1s.txt item: #132 of 440 id: cord-029537-hzy13fuw author: Soltani, Farhad title: The effect of melatonin on reduction in the need for sedative agents and duration of mechanical ventilation in traumatic intracranial hemorrhage patients: a randomized controlled trial date: 2020-07-22 words: 3002 flesch: 45 summary: Criti Care Nurs Clini Adverse events associated with sedatives, analgesics, and other drugs that provide patient comfort in the intensive care unit The association between sedation practices and duration of mechanical ventilation in intensive care Comparison of effects of melatonin and gabapentin on post operative anxiety and pain in lumbar spine surgery: a randomized clinical trial Melatonin supplementation may improve the outcome of patients with hemorrhagic stroke in the intensive care unit Low melatonin excretion during mechanical ventilation in the intensive care unit Delirium and circadian rhythm of melatonin during weaning from mechanical ventilation: an ancillary study of a weaning trial Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial Melatonin pharmacological blood levels increase total antioxidant capacity in critically Ill patients Melatonin: pharmacology, functions and therapeutic benefits Melatonin as a therapy for traumatic brain injury: a review of published evidence Melatonin attenuates early brain injury after subarachnoid hemorrhage by the JAK-STAT signaling pathway A comparative study of the amount of bleeding and hemodynamic changes between dexmedetomidine infusion and remifentanil infusion for controlled hypotensive anesthesia in lumbar discopathy surgery: A double-blind, randomized, clinical trial We sincerely thank the patients who cooperated with us in this project and supported the research team. key: cord-029537-hzy13fuw authors: Soltani, Farhad; Salari, Amir; Javaherforooshzadeh, Fatemeh; Nassajjian, Nozar; Kalantari, Farahmand title: The effect of melatonin on reduction in the need for sedative agents and duration of mechanical ventilation in traumatic intracranial hemorrhage patients: a randomized controlled trial date: 2020-07-22 journal: keywords: control; group; hemorrhage; icu; melatonin; patients; study; ventilation cache: cord-029537-hzy13fuw.txt plain text: cord-029537-hzy13fuw.txt item: #133 of 440 id: cord-029770-72ncfyc5 author: Farasat, Sadaf title: Sleep and Delirium in Older Adults date: 2020-07-27 words: 5911 flesch: 23 summary: Bedside staff (i.e., nurses) can complete the RCSQ on their patients' behalf, but have been shown to overestimate patient sleep quality [97] ; hence, proxy completion should be performed with caution. In older hospitalized adults, sleep quality is particularly poor, averaging 2.5 fewer hours than home [50] . keywords: adults; care; delirium; hospital; icu; interventions; melatonin; patients; quality; review; risk; sleep; study; unit cache: cord-029770-72ncfyc5.txt plain text: cord-029770-72ncfyc5.txt item: #134 of 440 id: cord-030927-wo8r8zny author: Collins, Curtis D title: Perspectives from the frontline: A pharmacy department’s response to the COVID-19 pandemic date: 2020-06-22 words: 4478 flesch: 32 summary: A 32-bed overflow special pathogens unit, previously equipped for management of critical care patients during a disaster response, was opened. Pharmacists intervened to address a wide scope of medication-related issues, likely contributing to improved management of COVID-19 patients. keywords: antimicrobial; care; covid-19; interventions; management; pandemic; patients; pharmacists; pharmacy; study cache: cord-030927-wo8r8zny.txt plain text: cord-030927-wo8r8zny.txt item: #135 of 440 id: cord-031143-a1qyadm6 author: Pinto Neto, Osmar title: Compartmentalized mathematical model to predict future number of active cases and deaths of COVID-19 date: 2020-08-30 words: 5291 flesch: 46 summary: Lack of testing and under-notification of active cases has been largely reported for the COVID-19 (Hasell et al. 2020; WorldoMeter, 2020; UFPel, 2020) ; in consequence, active cases data were corrected by a factor. Our main findings were as follows: (a) our model was able to accurately fit the either deaths or active cases data of all countries tested independent of what stage of the epidemic they were using optimized coefficient values in agreement with recent reports; (b) when trying to fit both sets of data at the same time, fit was good for some countries, but not for all; (c) using our model, large ranges for each input, and (black circles for deaths and green circle for active cases). keywords: cases; covid-19; data; deaths; model; number; rate; results cache: cord-031143-a1qyadm6.txt plain text: cord-031143-a1qyadm6.txt item: #136 of 440 id: cord-031327-uhrkb1p6 author: Koeze, Jacqueline title: Bundled care in acute kidney injury in critically ill patients, a before-after educational intervention study date: 2020-09-03 words: 3571 flesch: 51 summary: These results are in contrast with the few studies that evaluated AKI care bundles in hospitalized patients in general or in patients after cardiac surgery [15, 16] . Future research of our group and others on the effect of AKI care bundles in critically ill patients need to address this issue. keywords: aki; bundle; care; group; icu; patients; study cache: cord-031327-uhrkb1p6.txt plain text: cord-031327-uhrkb1p6.txt item: #137 of 440 id: cord-031710-1xl2isee author: Andrei, Stefan title: Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report date: 2020-09-10 words: 2586 flesch: 37 summary: Stenotrophomonas maltophilia-induced pulmonary haemorrhage is considered a fatal infection among haematological patients. Stenotrophomonas maltophilia severe pneumonia complicated with pulmonary haemorrhage is not always fatal in haematological patients. keywords: case; colistin; days; maltophilia; patient; stenotrophomonas; treatment cache: cord-031710-1xl2isee.txt plain text: cord-031710-1xl2isee.txt item: #138 of 440 id: cord-032335-6c9gt7t9 author: Segrelles-Calvo, Gonzalo title: Therapeutic limitation in elderly patients: Reflections regarding COVID19() date: 2020-09-19 words: 1310 flesch: 37 summary: The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study Association of frailty with short-term outcomes, organ support and resource use in critically ill patients Global prevalence of physical frailty by Fried's criteria in community-dwelling elderly with national population-based surveys Fair allocation of scarce medical resources in the time of Covid-19 Prevalence by age group is 7% in >65-year-olds and 20% in >80year-olds 6 and between 23% and 30% 8, 9 in ICU patients. keywords: frailty; icu; patients cache: cord-032335-6c9gt7t9.txt plain text: cord-032335-6c9gt7t9.txt item: #139 of 440 id: cord-033291-190taco9 author: Aboelnile, Diaaeldin Badr Metwally Kotb title: Prediction of fluid responsiveness in mechanically ventilated patients in surgical intensive care unit by pleth variability index and inferior vena cava diameter date: 2020-10-07 words: 4213 flesch: 33 summary: Fluid responsiveness and shock assessment Assessing dynamic fluid-responsiveness using transthoracic echocardiography in intensive care Influence of the site of measurement on the ability of plethysmographic variability index to predict fluid responsiveness Volume responsiveness in critically ill patients: use of sonography to guide management Goal-directed fluid management based on the pulse oximeter-derived pleth variability index reduces lactate levels and improves fluid management Monitoring volume and fluid responsiveness: from static to dynamic indicators Prediction of volume responsiveness using pleth variability index in patients undergoing cardiac surgery after cardiopulmonary bypass Value of variation index of inferior vena cava diameter in predicting fluid responsiveness in patients with circulatory shock receiving mechanical ventilation: a systematic review and meta-analysis Predicting fluid responsiveness: a review of literature and a guide for the clinician Ability of pleth variability index to detect hemodynamic changes induced by passive leg raising in spontaneously breathing volunteers APACHE II: a severity of disease classification system Respiratory pulse pressure variation fails to predict fluid responsiveness in acute respiratory distress syndrome Reliability of pleth variability index in predicting preload responsiveness of mechanically ventilated patients under various conditions: a systematic review and meta-analysis Paediatric Research in Emergency Departments International Collaborative (PREDICT) (2017) Does respiratory variation in inferior vena cava diameter predict fluid responsiveness: a systematic review and meta-analysis Does the central venous pressure predict fluid responsiveness? key: cord-033291-190taco9 authors: Aboelnile, Diaaeldin Badr Metwally Kotb; Elseidy, Mohamed Ismail Abdelfattah; Kenawey, Yasir Ahmed Elbasiony Mohamed; Elsherif, Ibrahim Mohammed Alsayed Ahmed title: Prediction of fluid responsiveness in mechanically ventilated patients in surgical intensive care unit by pleth variability index and inferior vena cava diameter date: 2020-10-07 journal: Ain-Shams J Anesthesiol DOI: 10.1186/s42077-020-00097-4 sha: doc_id: 33291 cord_uid: 190taco9 BACKGROUND: keywords: analysis; divc; fluid; index; patients; pvi; responsiveness; study cache: cord-033291-190taco9.txt plain text: cord-033291-190taco9.txt item: #140 of 440 id: cord-034185-e0am7pa6 author: Piccioni, Federico title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 words: 18225 flesch: 22 summary: Similarly, a meta-analysis of 32 trials involving approximately 2800 patients found a significant reduction in postoperative mortality with goal-directed therapy, compared with controls, in patients at highest risk of postoperative complications (OR 0.20, 95% CI 0.09-0.41, P < 0.0001); there was also a significant reduction in complication rates (OR 0.45, 95% CI 0.34-0.60, P < 0.00001), which was particularly marked in the highest risk subgroup (OR 0.27, 95% CI 0.15-0.51, P < 0.0001) (Cecconi et al. 2013) . Pinheiro et al. 2015) , more extensive resection (Cywinski et al. 2009 ), and impaired preoperative lung function or pulmonary comorbidities such as chronic obstructive pulmonary disease (COPD) (Brunelli et al. 2008; Cywinski et al. 2009; keywords: analgesia; analysis; anesthesia; chest; complications; et al; evidence; level; lung; management; meta; pain; patients; postoperative; pulmonary; randomized; recommendation; resection; risk; strength; studies; study; surgery; thoracic; thoracic surgery; trial; tube; use; ventilation cache: cord-034185-e0am7pa6.txt plain text: cord-034185-e0am7pa6.txt item: #141 of 440 id: cord-034286-m1c98nv7 author: Wijdicks, Eelco F. M. title: Communicating Neurocritical Illness: The Anatomy of Misunderstanding date: 2020-10-27 words: 3540 flesch: 51 summary: None. Using texting for clinical communication in surgery: a survey of academic staff surgeons Secure clinical texting: patient risk in high-acuity care Email for clinical communication between healthcare professionals Leading article: use of smartphones to pass on information about patients-what are the current issues? We can consider using simulation centers, which might be ideal set-ups for communication scenarios; these could include scenarios with deliberately confusing or vague language to recreate the potential downstream consequences for management. keywords: care; communication; hospital; icu; information; need; patient; time cache: cord-034286-m1c98nv7.txt plain text: cord-034286-m1c98nv7.txt item: #142 of 440 id: cord-034578-i9rdubix author: Vaschetto, Rosanna title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 words: 3688 flesch: 42 summary: The rate of mortality observed in our study, is not divergent from those reported in several prior studies [9, 10, 15, 12, 13] for ICU patients, predominantly intubated, which varied from 17% [13] to 67% key: cord-034578-i9rdubix authors: Vaschetto, Rosanna; Barone-Adesi, Francesco; Racca, Fabrizio; Pissaia, Claudio; Maestrone, Carlo; Colombo, Davide; Olivieri, Carlo; De Vita, Nello; Santangelo, Erminio; Scotti, Lorenza; Castello, Luigi; Cena, Tiziana; Taverna, Martina; Grillenzoni, Luca; Moschella, Maria Adele; Airoldi, Gianluca; Borrè, Silvio; Mojoli, Francesco; Della Corte, Francesco; Navalesi, Paolo; Cammarota, Gianmaria; Baggiani, Marta; Baino, Sara; Balbo, Piero; Bazzano, Simona; Bonato, Valeria; Carbonati, Sara; Crimaldi, Federico; Daffara, Veronica; De Col, Luca; Maestrone, Matteo; Malerba, Mario; Moroni, Federica; Perucca, Raffaella; Pirisi, Mario; Rondi, Valentina; Rosalba, Daniela; Vanni, Letizia; Vigone, Francesca title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 journal: keywords: cpap; hospital; icu; intubation; mortality; patients; study; treatment cache: cord-034578-i9rdubix.txt plain text: cord-034578-i9rdubix.txt item: #143 of 440 id: cord-035216-gdhz7mr4 author: Li, Xiaoran title: Deep learning prediction of likelihood of ICU admission and mortality in COVID-19 patients using clinical variables date: 2020-11-06 words: 3783 flesch: 44 summary: In risk score models, SPSS was used to cross-check statistical significance of the top features, in which all top features used in the final analysis of risk score model had a p < 0.001. Although we ranked all variables and explicitly listed 10 or 15 top variables, we built the predictive model and risk score model using only the top five variables to simplify and increase translation potential in the clinical settings. keywords: admission; data; icu; model; mortality; patients; risk; score; variables cache: cord-035216-gdhz7mr4.txt plain text: cord-035216-gdhz7mr4.txt item: #144 of 440 id: cord-035315-j5mknuv5 author: Rahim, Fawad title: Mortality of Patients With Severe COVID-19 in the Intensive Care Unit: An Observational Study From a Major COVID-19 Receiving Hospital date: 2020-10-12 words: 2715 flesch: 54 summary: This necessitated determining the survival of COVID-19 patients in relation to comorbid conditions and ventilatory support in our population. The high mortality with IMV patients could be due to inadequate intensive care services and lack of enough experience with treating COVID-19 related acute respiratory distress syndrome. keywords: age; covid-19; icu; mortality; patients; study cache: cord-035315-j5mknuv5.txt plain text: cord-035315-j5mknuv5.txt item: #145 of 440 id: cord-048343-nzk8m912 author: Milbrandt, Eric B title: Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics date: 2006-11-15 words: 5793 flesch: 28 summary: An experimental study in dogs Cerebral hemodynamics, vascular reactivity, and metabolism during canine endotoxin shock Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets Neuropathology of septic shock Multifocal necrotizing leukoencephalopathy in septic shock Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock The neuropathology of septic shock The role of hypotension in septic encephalopathy following surgical procedures Cerebral circulation and metabolism in patients with septic encephalopathy Different C-reactive protein kinetics in post-operative hip-fractured geriatric patients with and without complications The role of oxidative stress in postoperative delirium Regional cerebral blood flow in delirium patients Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome Hyperglycemia and neurocognitive outcome in ARDS survivors Hyperglycemia augments ischemic brain injury: in vivo MR imaging/spectroscopic study with nicardipine in cats with occluded middle cerebral arteries Signs of brain cell injury during open heart operations: past and present Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein Is there an association between release of protein S100B during cardiopulmonary bypass and memory disturbances? Although there are no studies evaluating the effectiveness of cognitive rehabilitation in patients recovering from non-neurologic critical illness, it stands to reason that such patients could benefit when they are found to be cognitively impaired. keywords: acute; anticholinergic; brain; delirium; icu; illness; injury; levels; mechanisms; patients; serum; studies; study cache: cord-048343-nzk8m912.txt plain text: cord-048343-nzk8m912.txt item: #146 of 440 id: cord-103686-er8llst4 author: Carboni Bisso, I. title: Influenza season 2019: analysis of 143 hospitalized cases date: 2020-09-18 words: 2428 flesch: 43 summary: Also dyspnoea was more frequent in ICU patients (69.6% vs. 50.5%). In addition, elevation of serum transaminases was more frequently seen in ICU patients (37,5% vs. 8.0%), without associated involvement of alkaline phosphatase, bilirubin or prothrombin time. keywords: icu; influenza; license; medrxiv; patients; preprint cache: cord-103686-er8llst4.txt plain text: cord-103686-er8llst4.txt item: #147 of 440 id: cord-124012-5zxkd2jy author: Schwab, Patrick title: predCOVID-19: A Systematic Study of Clinical Predictive Models for Coronavirus Disease 2019 date: 2020-05-17 words: 5102 flesch: 24 summary: Here, we study clinical predictive models that estimate, using machine learning and based on routinely collected clinical data, which patients are likely to receive a positive SARS-CoV-2 test, require hospitalisation or intensive care. The adoption of clinical predictive models that accurately predict who is likely to require testing, hospitalisation and intensive care from routinely collected clinical data could potentially further reduce peak demand by ensuring resources are prioritised to those individuals with the highest risk ( Figure 1 ). keywords: admission; cov-2; covid-19; data; hospital; models; patients; predictive; sars; test cache: cord-124012-5zxkd2jy.txt plain text: cord-124012-5zxkd2jy.txt item: #148 of 440 id: cord-133273-kvyzuayp author: Christ, Andreas title: Artificial Intelligence: Research Impact on Key Industries; the Upper-Rhine Artificial Intelligence Symposium (UR-AI 2020) date: 2020-10-05 words: 42474 flesch: 53 summary: [16] have shown, that, despite their initial design for image data, a residual neural network (ResNet) can perform quite well on time-series classification. Additionally, it discusses whether more general requirements can be sufficiently addressed in the scenarios, as e.g. proposed in ethical guidelines for AI based systems like [9, 10] . keywords: algorithm; approach; behavior; bottle; case; classification; data; dataset; deep; detection; devices; evaluation; example; features; figure; human; image; information; input data; learning; level; machine; methods; model; networks; object; parameters; patient; point; process; processing; product; quality; real; reality; results; robot; set; size; space; speed; step; stress; structure; system; time; training; training data; type; use; user; validation; walk cache: cord-133273-kvyzuayp.txt plain text: cord-133273-kvyzuayp.txt item: #149 of 440 id: cord-140624-lphr5prl author: Grundel, Sara title: How much testing and social distancing is required to control COVID-19? Some insight based on an age-differentiated compartmental model date: 2020-11-02 words: 8723 flesch: 56 summary: As a remedy, we designed optimal social distancing strategies with a focus on applicability and acceptance in the general population, i.e. strategies with slowly changing contact reductions. Agedifferentiated contact reductions may improve upon these results as they yield qualitatively similar social distancing strategies and prioritize relaxing restrictions for the work-force and children. keywords: age; cases; control; covid-19; distancing; infectious; model; number; social; testing; time cache: cord-140624-lphr5prl.txt plain text: cord-140624-lphr5prl.txt item: #150 of 440 id: cord-201783-66fmse66 author: Maslov, Sergei title: Window of Opportunity for Mitigation to Prevent Overflow of ICU capacity in Chicago by COVID-19 date: 2020-03-21 words: 2422 flesch: 52 summary: The goal of our numerical experiments was to estimate the effect of strong mitigation scenarios on the peak number of severe cases (requiring hospitalization), peak number of critical cases (requiring hospitalization and special treatment) and total number of deaths. (2) Strong mitigation can avert this emergency situation potentially, but even that will not work if implemented too late. keywords: chicago; epidemic; icu; mitigation; time cache: cord-201783-66fmse66.txt plain text: cord-201783-66fmse66.txt item: #151 of 440 id: cord-221717-h1h2vd3r author: Scabini, Leonardo F. S. title: Social Interaction Layers in Complex Networks for the Dynamical Epidemic Modeling of COVID-19 in Brazil date: 2020-05-16 words: 8581 flesch: 51 summary: The largest difference that appears right after the first confirmed case may indicate a significant underdetection of COVID-19 cases. The peak occurs at 108 days (June 13) with an average of 40,937 (± 11,010) new cases, and at 122 days (June 27) with an average of 6,484 (± 1,739) new deaths. keywords: average; cases; days; epidemic; isolation; layer; model; network; number; people; social; time cache: cord-221717-h1h2vd3r.txt plain text: cord-221717-h1h2vd3r.txt item: #152 of 440 id: cord-234254-svjajpp4 author: Kohler, J. title: Robust and optimal predictive control of the COVID-19 outbreak date: 2020-05-07 words: 13166 flesch: 52 summary: [12] in order to design control policies which minimize the number of fatalities within a time horizon of two years, without using excessive social distancing measures. Applying an optimizer to the mathematical model describing the outbreak, one can significantly reduce the number of fatalities without increasing the costs associated to decreasing the infection rate (social distancing policies, closing schools, etc.), compare Section 3.2. keywords: control; covid-19; fatalities; measures; model; number; outbreak; policy; rate; section; time cache: cord-234254-svjajpp4.txt plain text: cord-234254-svjajpp4.txt item: #153 of 440 id: cord-251977-rgae9jy9 author: Terrasi, Benjamin title: French ICUs fight back: an example of regional ICU organisation to tackle the SARS Cov-2 outbreak date: 2020-04-30 words: 1047 flesch: 61 summary: key: cord-251977-rgae9jy9 authors: Terrasi, Benjamin; Arnaud, Emilien; Guilbart, Mathieu; Besserve, Patricia; Mahjoub, Yazine title: French ICUs fight back: an example of regional ICU organisation to tackle the SARS Cov-2 outbreak date: 2020-04-30 journal: Anaesth Crit Care Pain Med DOI: 10.1016/j.accpm.2020.03.018 sha: doc_id: To tackle the outbreak, the number of ICU beds doubled in less than 2 weeks in these public and private hospitals. keywords: amiens; icu; picardy cache: cord-251977-rgae9jy9.txt plain text: cord-251977-rgae9jy9.txt item: #154 of 440 id: cord-252286-377y9aqx author: Gauss, Tobias title: Preliminary pragmatic lessons from the SARS-CoV-2 pandemic from France date: 2020-05-13 words: 2161 flesch: 39 summary: Those adaptations were sometimes met with distrust and anxiety by health care professionals, as they were considered as a consequence of PPE shortage and not evidence-based. Abstract The first wave of the SARS-CoV-2 pandemic required an unprecedented and historic increase in critical care capacity on a global scale in France. keywords: care; crisis; pandemic; patients; professionals; sars cache: cord-252286-377y9aqx.txt plain text: cord-252286-377y9aqx.txt item: #155 of 440 id: cord-252737-sbalcd8v author: Ma, Xiya title: Critical care capacity during the COVID-19 pandemic: Global availability of intensive care beds date: 2020-04-23 words: 699 flesch: 44 summary: While several studies have evaluated critical care capacity in some regions, there has yet to be a comprehensive survey of ICU beds worldwide. key: cord-252737-sbalcd8v authors: Ma, Xiya; Vervoort, Dominique title: Critical care capacity during the COVID-19 pandemic: Global availability of intensive care beds date: 2020-04-23 journal: J Crit Care DOI: 10.1016/j.jcrc.2020.04.012 sha: doc_id: 252737 cord_uid: sbalcd8v nan As the COVID-19 pandemic grows, the need for rapid, innovative, and cost-effective emergency response mechanisms and the presence of gaps in critical care capacity become glaringly obvious in most countries and territories worldwide. keywords: beds; icu cache: cord-252737-sbalcd8v.txt plain text: cord-252737-sbalcd8v.txt item: #156 of 440 id: cord-253049-vm46wq1m author: Rößler, Steve title: Influenza-associated in-hospital mortality during the 2017/2018 influenza season: a retrospective multicentre cohort study in central Germany date: 2020-09-27 words: 1937 flesch: 44 summary: To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/. Erkrankungen durch saisonale Influenzaviren Impact of infectious diseases on population health using incidence-based disability-adjusted life years (DALYs): results from the Burden of Communicable Diseases in Europe study, European Union and European Economic Area countries Bericht zur Epidemiologie der Influenza in Deutschland Assessment of deaths from COVID-19 and from seasonal influenza Clinical characteristics of influenza in season 2017/2018 in a German Emergency Department: a retrospective analysis Intrahospital mortality of influenza patients during the 2017-2018 influenza season: report from a tertiary care hospital in Austria Characteristics and management of patients with influenza in a German hospital during the 2014/2015 influenza season Since it is possible that not every microbiologically confirmed influenza infection was coded at discharge and that microbiological diagnostics were not always performed to ensure the clinically suspected diagnosis, the true number of hospitalized influenza patients could be correspondingly higher than that reported here. keywords: hospital; influenza; mortality; patients cache: cord-253049-vm46wq1m.txt plain text: cord-253049-vm46wq1m.txt item: #157 of 440 id: cord-253281-95ubt4k1 author: Wilson, Lauren A. title: Return to Normal: Prioritizing Elective Surgeries With Low Resource Utilization date: 2020-05-04 words: 763 flesch: 26 summary: We therefore evaluated intensive care unit (ICU) utilization and mechanical ventilation following common elective surgical procedures to (1) determine which procedures are the least resource intensive and (2) which patient populations are less likely to require postoperative ICU admission or ventilation. Outside of cardiac procedures, postoperative ventilation was relatively uncommon, indicating that limiting elective procedures is primarily beneficial in maximizing ICU capacity rather than freeing up ventilators. keywords: icu; ventilation cache: cord-253281-95ubt4k1.txt plain text: cord-253281-95ubt4k1.txt item: #158 of 440 id: cord-254688-1poiheen author: De Brouwer, E. title: Can herd immunity be achieved without breaking ICUs? date: 2020-05-27 words: 2575 flesch: 53 summary: If correct, this would imply that 4 in 1,000 people would require ICU care at the epidemic peak, while preexisting ICU bed capacity in high-income countries [9] ranges from 4.2 per 100,000 inhabitants (Portugal) to 34.7 per 100,000 (United States). The containment measures put in place to control the outbreaks had a huge social and economic impacts, and countries are looking for strategies to relax these measures while maintaining the R_0 close or below 1, in an attempt to safely reach herd immunity. keywords: capacity; herd; icu; immunity; population cache: cord-254688-1poiheen.txt plain text: cord-254688-1poiheen.txt item: #159 of 440 id: cord-254818-dzsyuwpy author: Bangash, Mansoor N title: COVID-19 recovery: potential treatments for post-intensive care syndrome date: 2020-10-12 words: 1409 flesch: 26 summary: 7 Other drugs, or dietary supplementation with compounds that increase proresolution mediators and reduce thrombo-inflammation, might also be expected to reduce cardiovascular and overall morbidity in patients with PICS; cardiovascular trials of aspirin and icosapent ethyl provide evidence of efficacy. We suggest that the research pathway for such trials should be based on prognostic enrichment through clinical and cardiovascular or immune biomarker profiles, and initially use established drugs that modify cardiometabolic risk in ICU survivors who might not have traditionally recognised cardiovascular risk factors, through randomised controlled trials led by intensive care specialists. keywords: care; icu; intensive; patients; pics cache: cord-254818-dzsyuwpy.txt plain text: cord-254818-dzsyuwpy.txt item: #160 of 440 id: cord-254990-nrzwn6oz author: Mayer, Kirby P. title: Recovery from COVID-19 and acute respiratory distress syndrome: the potential role of an intensive care unit recovery clinic: a case report date: 2020-09-10 words: 3124 flesch: 43 summary: Coronavirus disease 2019 (COVID-19) pandemic Reference equations for the six-minute walk in healthy adults Survival rate in acute kidney injury superimposed COVID-19 patients: a systematic review and meta-analysis Implementation of an ICU recovery clinic at a tertiary care academic center Comprehensive care of ICU survivors: development and implementation of an ICU recovery center CE: critical care recovery center: an innovative collaborative care model for ICU survivors The ICU follow-up clinic: a new paradigm for intensivists Chaos theory: optimizing critical illness outcomes through the family experience -a theoretical review Clinical practice guidelines for support of the family in the patient-centered intensive care unit: American College of Critical Care Medicine Task Force Family response to critical illness: postintensive care syndrome -family Key components of ICU recovery programs: what did patients report provided benefit? Physical function impairment in survivors of critical illness in an ICU recovery clinic Understanding, compliance and psychological impact of the SARS quarantine experience The psychological impact of quarantine and how to reduce it: rapid review of the evidence Comprehensive review of mask utility and challenges during the COVID-19 pandemic Public health measures and the reproduction number of SARS-CoV-2 Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study Physical complications in acute lung injury survivors: a two-year longitudinal prospective study Functional disability 5 years after acute respiratory distress syndrome Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study Co-occurrence of post-intensive care syndrome problems among 406 survivors of critical illness Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19 Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations The purpose of this case report is to highlight the potential role of intensive care unit recovery or follow-up clinics for patients surviving acute hospitalization for coronavirus disease 2019. keywords: care; clinic; covid-19; day; follow; icu; patient; recovery; unit cache: cord-254990-nrzwn6oz.txt plain text: cord-254990-nrzwn6oz.txt item: #161 of 440 id: cord-255256-8uckmya4 author: None title: Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date: 2020-08-18 words: 3536 flesch: 45 summary: Methods: This retrospective study evaluated intensive care unit patients who underwent CVVH with RCA between 2016 and 2017. Severity of AKI was categorized according to KDIGO Methods: This retrospective study evaluated intensive care unit patients who underwent CVVH with RCA between 2016 and 2017. keywords: blood; cvvh; der; die; icu; mean; patients; study; therapy; und cache: cord-255256-8uckmya4.txt plain text: cord-255256-8uckmya4.txt item: #162 of 440 id: cord-255435-mr239gai author: Sher, Yelizaveta title: A CASE REPORT OF COVID-19 ASSOCIATED HYPERACTIVE ICU DELIRIUM WITH PROPOSED PATHOPHYSIOLOGY AND TREATMENT date: 2020-05-19 words: 3529 flesch: 31 summary: While no studies have demonstrated pharmacological efficacy in the management of delirium among COVID-19 patients, we provide a framework for choosing psychotropic medications to assist in achieving behavioral control in ICU patients. Delirium, which is highly prevalent in general intensive care unit (ICU) populations, is expected to be frequent and prominent in COVID-19 patients hospitalized with acute respiratory distress syndrome (ARDS) in ICU. keywords: case; covid-19; day; delirium; icu; management; patients; treatment cache: cord-255435-mr239gai.txt plain text: cord-255435-mr239gai.txt item: #163 of 440 id: cord-255827-xz87wg74 author: Sills, Marion R. title: Inpatient Capacity at Children’s Hospitals during Pandemic (H1N1) 2009 Outbreak, United States date: 2011-09-17 words: 3675 flesch: 36 summary: how data from a pediatric health information system earns the trust of its users H1N1 fl u: situation update Infl uenza viruses isolated by WHO/NREVSS collaborating laboratories, 2009-2010 season The effect of hospital bed occupancy on throughput in the pediatric emergency department Hospital capacity, patient fl ow, and emergency department use in New Jersey. We included all hospitalized patients of any admission status (observation or inpatient) to fully quantify hospital occupancy. keywords: children; h1n1; hospitals; icu; infl; occupancy; pandemic; uenza cache: cord-255827-xz87wg74.txt plain text: cord-255827-xz87wg74.txt item: #164 of 440 id: cord-256294-9gmn4fcj author: Almazrou, Saja H. title: Comparing the impact of Hydroxychloroquine based regimens and standard treatment on COVID-19 patient outcomes: A retrospective cohort study date: 2020-10-01 words: 3012 flesch: 43 summary: Larger observational studies and RCTs that evaluate the efficacy of HCQ in COVID-19 patients in the Saudi population are urgently needed. Chloroquine and Hydroxychloroquine (HCQ) is among the promising treatment modalities for COVID-19 patients Geleris et al., 2020; Rosenberg et al., 2020; Shen et al., 2020) . keywords: covid-19; hcq; patients; study; treatment cache: cord-256294-9gmn4fcj.txt plain text: cord-256294-9gmn4fcj.txt item: #165 of 440 id: cord-256424-t3dtabi4 author: Bousbia, Sabri title: Repertoire of Intensive Care Unit Pneumonia Microbiota date: 2012-02-28 words: 5650 flesch: 34 summary: Some pathogens considered to be typical for ICU pneumonia such as Pseudomonas aeruginosa and Streptococcus species can be detected as commonly in controls as in pneumonia patients which strikingly highlights the existence of a core pulmonary microbiota. In preliminary results, we have reported the likely frequency of Tropheryma whipplei and the occurrence of vegetable DNA in pneumonia patients [12, 13] . keywords: bacteria; bal; controls; culture; fungi; icu; patients; phylotypes; pneumonia; species; studies; study; viruses cache: cord-256424-t3dtabi4.txt plain text: cord-256424-t3dtabi4.txt item: #166 of 440 id: cord-256533-slbfft33 author: Gomez Rial, J. title: Increased serum levels of sCD14 and sCD163 indicate a preponderant role for monocytes in COVID-19 immunopathology date: 2020-06-04 words: 2857 flesch: 39 summary: Median levels for sCD163 in sera from ICU patients were 911.5 (95%CI: 624.7-1167.0) ng/ml, and 910.4 (95%CI: 733.1-1088.0) ng/ml in non-ICU patients. We did not observe any differences between ICU or non-ICU patients, probably due to the interference on monocyte function produced by the use of tocilizumab and/or corticoid treatment in ICU patients as previously demonstrated [18; 19] . keywords: icu; levels; medrxiv; monocyte; patients; preprint cache: cord-256533-slbfft33.txt plain text: cord-256533-slbfft33.txt item: #167 of 440 id: cord-256746-ggnd8y06 author: Flythe, Jennifer E. title: Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States date: 2020-09-19 words: 4414 flesch: 35 summary: [2-9] for dialysis patients; 7 [3-10] for CKD patients; 7 [4-10] for patients without pre-existing kidney disease). Compared to patients without pre-existing kidney disease, dialysis patients had a higher risk of 28-day in-hospital death (adjusted HR 1.41; 95% CI 1.09, 1.81), while patients with CKD had an intermediate risk (adjusted HR 1.25; 95% CI 1.08, 1.44). keywords: ckd; covid-19; dialysis; disease; hospital; kidney; kidney disease; patients cache: cord-256746-ggnd8y06.txt plain text: cord-256746-ggnd8y06.txt item: #168 of 440 id: cord-256790-odlcfhcr author: Alviset, S. title: Continuous positive airway pressure face-mask ventilation to manage massive influx of patients requiring respiratory support during the SARS-CoV-2 outbreak date: 2020-06-03 words: 3867 flesch: 52 summary: We describe the characteristics, clinical course, and outcomes of COVID-19 patients treated with continuous positive airway pressure (CPAP) in a large public hospital in France. Optimal respiratory support for COVID-19 patients presenting with acute hypoxemic respiratory failure, however, remains unknown. keywords: copyright; cpap; holder; medrxiv; patients; perpetuity; preprint; version cache: cord-256790-odlcfhcr.txt plain text: cord-256790-odlcfhcr.txt item: #169 of 440 id: cord-257325-pvf0uon3 author: Zeitoun, Jean-David title: Impact of Local Care Environment and Social Characteristics on Aggregated Hospital-Fatality Rate from COVID-19 in France: Nationwide Observational Study date: 2020-10-10 words: 2373 flesch: 49 summary: Thirdly, we did not have access to hospital data or patient data. 4 Fatality rate, defined as the number of deaths of patients in whom COVID-19 was confirmed, divided by the total number of COVID-19 cases, seems to vary among countries. keywords: covid-19; fatality; hospital; rate cache: cord-257325-pvf0uon3.txt plain text: cord-257325-pvf0uon3.txt item: #170 of 440 id: cord-257361-7q0vbvvd author: Lee, James S. title: Critical care for COVID-19 during a humanitarian crisis—lessons learnt from Yemen date: 2020-09-23 words: 1297 flesch: 47 summary: Invasive mechanical ventilation (IMV) received global attention but is only the visible tip of the iceberg for COVID-19 care. Routine ICU care, such as ventilator settings, ventilator-associated pneumonia prevention bundles, infusion pump usage, and early mobility, amongst others, were unfamiliar. keywords: care; icu; oxygen; patients cache: cord-257361-7q0vbvvd.txt plain text: cord-257361-7q0vbvvd.txt item: #171 of 440 id: cord-257504-tqzvdssb author: Dubost, Clément title: Preparation of an intensive care unit in France for the reception of a confirmed case of Ebola virus infection() date: 2015-11-24 words: 5150 flesch: 54 summary: It is now clear that northern countries will be implicated in the care of EVD patients, both in the field and back at home. It is now clear that northern countries will be implicated in the care of EVD patients, both in the field and back at home. keywords: care; case; disease; ebola; evd; icu; patient; risk; room; staff; virus cache: cord-257504-tqzvdssb.txt plain text: cord-257504-tqzvdssb.txt item: #172 of 440 id: cord-258027-f3rr5el1 author: Østby, Anne‐Cathrine title: Respiratory virology and microbiology in intensive care units: a prospective cohort study date: 2013-05-18 words: 5260 flesch: 33 summary: In conclusion, respiratory viruses were frequently detected in the patients. The investigated clinical and paraclinical parameters were not different in viral infections compared to other agents, thus respiratory viruses likely have similar impact on the clinical course as other agents. keywords: bacteria; icu; influenza; patients; results; study; virus; viruses cache: cord-258027-f3rr5el1.txt plain text: cord-258027-f3rr5el1.txt item: #173 of 440 id: cord-258582-ksfs27kv author: Nadeem, Ashraf title: ICU outcomes of COVID-19 critically ill patients: an international comparative study date: 2020-07-03 words: 1171 flesch: 62 summary: In conclusion, ICU mortality of COVID-19 patients is highly variable between the different cohorts and not explained by the MV's different rates. Series of ICU patients with confirmed COVID-19 infection from published cohorts were included [2] [3] [4] [5] [6] . keywords: cohorts; icu; patients cache: cord-258582-ksfs27kv.txt plain text: cord-258582-ksfs27kv.txt item: #174 of 440 id: cord-259984-csdf1a69 author: Raffiq, Azman title: COVID-19 Pandemic and Its Impact on Neurosurgery Practice in Malaysia: Academic Insights, Clinical Experience and Protocols from March till August 2020 date: 2020-10-27 words: 16405 flesch: 43 summary: Clinical guide for the management of paediatric neurosurgery patients during the coronavirus pandemic Early lessons in the management of COVID-19 for the pediatric neurosurgical community from the leadership of the American Society of Pediatric Neurosurgeons Anaesthesia and sars Infographic for principles of airway management in COVID-19 World Federation of Societies of Anesthesiologists This publication is not a proposed National guideline for the COVID-19 Management of COVID-19 neurosurgical patients but a review of management and protocols from local and international peer reviewed and non-peer reviewed publications, web-based information and data until the month of August 2020. It is imperative to balance the requirements of caring for COVID-19 patients with imminent risk of delay to others who need care. keywords: airway; care; cases; covid-19; disease; emergency; health; hospital; icu; malaysia; management; medical; non; pandemic; patients; ppe; procedures; resources; risk; room; services; staff; stroke; surgery; team; treatment; use; ventilation cache: cord-259984-csdf1a69.txt plain text: cord-259984-csdf1a69.txt item: #175 of 440 id: cord-260822-4bselbkq author: Lotz, Christopher title: Unconventional approaches to mechanical ventilation—step-by-step through the COVID-19 crisis date: 2020-05-18 words: 1191 flesch: 40 summary: Ventilator triage would likely require switching of the ventilators during the course of treatment according to disease severity and stage as well as weaning capabilities, e.g., from anesthesia ventilator to ICU ventilator. ICU ventilators provide the highest performance, fast responding efficient triggering mechanisms, and often a plethora of different ventilation modes to best suit the individual patient. keywords: icu; patients; ventilation; ventilators cache: cord-260822-4bselbkq.txt plain text: cord-260822-4bselbkq.txt item: #176 of 440 id: cord-261354-8uwtwsug author: Settembre, Nicla title: The use of exoskeletons to help with prone positioning in the intensive care unit during COVID-19 date: 2020-06-10 words: 1224 flesch: 37 summary: Subjective evaluation, which is used in field studies to evaluate the adoption of exoskeletons in Prone positioning in severe acute respiratory distress syndrome COVID-19: Interim Guidance on Management Pending Empirical Evidence Flexion and rotation of the trunk and lifting at work are risk factors for low back pain: results of a prospective cohort study Processus d'acceptabilité et d'acceptation des exosquelettes: évaluation par questionnaires The effects of a passive exoskeleton on muscle activity, discomfort and endurance time in forward bending work Effects of a passive exoskeleton on the mechanical loading of the low back in static holding tasks The effect of a passive trunk exoskeleton on metabolic costs during lifting and walking Ethical and Social Considerations for the introduction of Human-Centered Technologies at Work An Introduction to the Special Issue on Occupational Exoskeletons Exoskeletons for industrial application and their potential effects on physical work load Subjective Evaluation of a Passive Industrial Exoskeleton for Lower-back Support: A Field Study in the Automotive Sector Our pilot study consisted of two steps: first, an exploratory study with whole-body kinematics assessment and evaluation of potential exoskeletons, carried out under simulated conditions, then implementation in a real-life situation with the selected exoskeletons. keywords: exoskeletons; icu; laevo cache: cord-261354-8uwtwsug.txt plain text: cord-261354-8uwtwsug.txt item: #177 of 440 id: cord-261485-0ke5nqy0 author: Sabir, A. M. title: Effects of Anticoagulants and Corticosteroids therapy in patients affected by severe COVID-19 Pneumonia date: 2020-06-29 words: 4666 flesch: 52 summary: It was also observed that severe COVID-19 patients had higher levels of IL-6, 18 , suggesting that the hypercoagulation status of COVID-19 patients may be related to the elevated levels of cytokines. Therefore, COVID-19 patients with exertional dyspnea with or without hypoxia should be admitted to hospitals, evaluated for pulmonary involvement clinically and radiologically, and treated early with anti-inflammatory and antiviral drugs. keywords: covid-19; days; oxygen; patients; pneumonia; preprint; treatment cache: cord-261485-0ke5nqy0.txt plain text: cord-261485-0ke5nqy0.txt item: #178 of 440 id: cord-262022-kvezhyt5 author: Kim, L. title: Interim Analysis of Risk Factors for Severe Outcomes among a Cohort of Hospitalized Adults Identified through the U.S. Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET) date: 2020-05-22 words: 4905 flesch: 48 summary: Prevention strategies, 345 such as social distancing and rigorous hand hygiene, are key to minimizing the risk of infection in high-346 risk patients. We rapidly implemented population-based surveillance for laboratory-97 confirmed COVID-19-associated hospitalizations, collecting clinical data from hospitalized patients in 154 98 hospitals in 13 states since March 1, 2020. keywords: admission; arr; copyright; license; medrxiv; patients; preprint cache: cord-262022-kvezhyt5.txt plain text: cord-262022-kvezhyt5.txt item: #179 of 440 id: cord-262623-lmf2h6oc author: Light, R. Bruce title: Plagues in the ICU: A Brief History of Community-Acquired Epidemic and Endemic Transmissible Infections Leading to Intensive Care Admission date: 2009-01-31 words: 7820 flesch: 39 summary: Over the ensuing weeks several more cases of severe respiratory syndromes began to appear in the region, also undiagnosed. Such superantigens have since been implicated in a number of other disease syndromes, among them the streptococcal toxic shock syndrome (see below). keywords: care; cases; disease; failure; health; icu; infection; influenza; outbreak; pandemic; patients; pneumonia; shock; syndrome; virus cache: cord-262623-lmf2h6oc.txt plain text: cord-262623-lmf2h6oc.txt item: #180 of 440 id: cord-262729-qcijsyo6 author: Eichberg, Daniel G title: Letter: Academic Neurosurgery Department Response to COVID-19 Pandemic: The University of Miami/Jackson Memorial Hospital Model date: 2020-04-11 words: 1091 flesch: 36 summary: With appropriate strategy, it is possible for an academic neurosurgical department to maintain its commitments to neurosurgical patients as well as their community at large and provide safe and effective neurosurgical treatment. Postoperative neurosurgical patients are often medically fragile; thus exposure to COVID-19 may be extremely deleterious. keywords: cases; clinic; patients; visits cache: cord-262729-qcijsyo6.txt plain text: cord-262729-qcijsyo6.txt item: #181 of 440 id: cord-263671-2b54qfo7 author: Soriano, María Cruz title: Low incidence of co-infection, but high incidence of ICU-acquired infections in critically ill patients with COVID-19 date: 2020-09-19 words: 984 flesch: 37 summary: These data are in agree Lansbury et al. and with others reports 1, 4 These findings support stopping empirical antibiotics in the vast majority of patients when COVID-19 infection is confirmed. However, it is important to remark that mortality in the subgroup of patients with co-infection was very high, with a mortality rate of 57.1% versus 21.1% in patient without co-infection (p = 0.033). keywords: icu; infection; patients cache: cord-263671-2b54qfo7.txt plain text: cord-263671-2b54qfo7.txt item: #182 of 440 id: cord-263703-5csf9z6s author: Fernandez Villalobos, N. V. title: Quantification of the association between predisposing health conditions, demographic, and behavioural factors with hospitalisation, intensive care unit admission, and death from COVID-19: a systematic review and meta-analysis date: 2020-08-01 words: 5761 flesch: 43 summary: We included reports if: a) patients had COVID-19, either confirmed microbiologically or clinically (population); b) information on COVID-19 outcome was reported as either death (hospital or after a defined follow-up time), ICU admission (both ICU and intermediate care), hospitalisation or aggravation of disease (clinical description) (outcome); and c) at least one comorbidity, risk factor or behavioural factor was described and if number of patients with/without outcome was reported according to the respective factor (exposure and comparison). Prog Cardiovasc Dis Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia -A systematic review, meta-analysis, and meta-regression Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis Arterial hypertension and risk of death in patients with COVID-19 infection: systematic review and metaanalysis Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement ROBINS-I: a tool for assessing risk of bias in non-randomized studies of interventions Clinical Features and Short-term Outcomes of 102 Patients with Corona Virus Disease Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019 Clinical and Transmission Characteristics of Covid-19 -A Retrospective Study of 25 Cases From a Single Thoracic Surgery Department Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: keywords: age; comorbidities; covid-19; disease; meta; patients; preprint; risk; studies cache: cord-263703-5csf9z6s.txt plain text: cord-263703-5csf9z6s.txt item: #183 of 440 id: cord-263883-7ba0huwy author: Ansarin, Khalil title: Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial date: 2020-07-19 words: 3121 flesch: 47 summary: The data analysis of this clinical trial also showed that cardinal respiratory symptoms (cough, lassitude, and dyspnea) in patients with COVID-19 disease who received bromhexine treatment was remarkably less than the standard group. Patients with COVID-19 disease release high amounts of LDH into circulation due to cytokine release and lung damage. keywords: arm; bromhexine; covid-19; disease; group; patients; standard; treatment cache: cord-263883-7ba0huwy.txt plain text: cord-263883-7ba0huwy.txt item: #184 of 440 id: cord-264614-2x7cdul3 author: Díaz-Guio, Diego Andrés title: COVID-19: Biosafety in the Intensive Care Unit date: 2020-08-27 words: 3860 flesch: 44 summary: However, the median time from intubation to death of COVID-19 patients has been reported to be on the 7th day [41] . This article aims to show the different strategies to prevent the widespread of the disease to critical care healthcare workers based on the review of the recent literature and the author's experience with the personal protective equipment (PPE) in the care of patients with COVID-19 and work on human factors in crisis management. keywords: care; covid-19; equipment; healthcare; icu; patients; personnel; respirators; use; workers cache: cord-264614-2x7cdul3.txt plain text: cord-264614-2x7cdul3.txt item: #185 of 440 id: cord-264829-ynel6ore author: Momtazmanesh, Sara title: Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool date: 2020-07-13 words: 7975 flesch: 43 summary: Interact Cardiovasc Thorac Surg Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range Hospitalization and critical care of 109 decedents with COVID-19 pneumonia in Wuhan, China Clinical features and treatment of COVID-19 patients in northeast Chongqing Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: a retrospective observational study Prognostic value of NT-proBNP in patients with severe COVID-19 Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-COVID-NET, 14 States Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) China Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2 Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized With COVID-19 Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Heart failure and liver disease: cardiohepatic interactions Cardiohepatic interactions in heart failure: an overview and clinical implications Right Heart Failure and Cardiorenal Syndrome An Update on the pathophysiology and treatment of cardiorenal syndrome Cardiorenal syndrome: multi-organ dysfunction involving the heart, kidney and vasculature Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin First case of COVID-19 complicated with fulminant myocarditis: a case report and insights Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to Ddimer levels COVID-19 pneumonia with hemoptysis: acute segmental pulmonary emboli associated with novel coronavirus infection Severe Acute Proximal Pulmonary Embolism and COVID-19: keywords: acute; analysis; clinical; coronavirus; covid-19; disease; frequency; icu; injury; levels; patients; studies cache: cord-264829-ynel6ore.txt plain text: cord-264829-ynel6ore.txt item: #186 of 440 id: cord-264889-1vsvcza2 author: Jackson, Craig T. title: The Ties That Bind: A Coronavirus Disease Journey date: 2020-10-16 words: 1129 flesch: 51 summary: As friends on a COVID journey, we shared our appreciation of ICU care as a team sport. Some describe COVID critical care management as creating a delirium factory. keywords: care; experience; icu; patient cache: cord-264889-1vsvcza2.txt plain text: cord-264889-1vsvcza2.txt item: #187 of 440 id: cord-264907-y4vefr98 author: Renke, Christine title: Utilization of Pediatric Nurse Practitioners as Adult Critical Care Providers During the COVID-19 Pandemic: A Novel Approach date: 2020-06-17 words: 2659 flesch: 43 summary: These processes were necessary to permit PNPs to practice to their full scope and ability in the provision of care to an overwhelming number of COVID-19 ICU patients. The team's focus expanded beyond individual patient care to include overall global health. keywords: apps; care; covid-19; icu; pandemic; patients; pnps; providers cache: cord-264907-y4vefr98.txt plain text: cord-264907-y4vefr98.txt item: #188 of 440 id: cord-265022-p5cab562 author: Kotfis, Katarzyna title: COVID-19: ICU delirium management during SARS-CoV-2 pandemic date: 2020-04-28 words: 5433 flesch: 28 summary: The Intensive Care Delirium Screening Checklist (ICDSC)--translation and validation of intensive care delirium checklist in accordance with guidelines A novel coronavirus from patients with pneumonia in China Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan Fair Allocation of Scarce Medical Resources in the Time of Covid-19 Sedative and analgesic medications are independent risk factors in ICU patients for transitioning into delirium Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients Caring for critically ill patients with the ABCDEF bundle: results of the ICU liberation collaborative in over 15,000 adults The ABCDEF bundle: science and philosophy of how ICU liberation serves patients and families Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF bundle in 6,064 patients Clinical and team management in the COVID-ICU: successful strategies from the first week Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Multiple organ infection and the pathogenesis of SARS Neurotropic virus tracing suggests a membranous-coatingmediated mechanism for transsynaptic communication SARS: clinical features and diagnosis The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Neuroinvasion by human respiratory coronaviruses Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human Dipeptidyl peptidase 4 Novel coronavirus is putting the whole world on alert Neurotropism of human coronavirus 229E Characteristics of a coronavirus (strain 67N) of pigs Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis Neurologic complications of coronavirus infections Coronavirus infections in the central nervous system and respiratory tract show distinct features in hospitalized children COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features. However, the standard of care for ICU patients, including delirium management, must remain the highest quality possible with an eye towards long-term survival and minimization of issues related to post-intensive care syndrome (PICS). keywords: acute; brain; care; coronavirus; cov-2; covid-19; delirium; icu; management; patients; risk; sars; unit cache: cord-265022-p5cab562.txt plain text: cord-265022-p5cab562.txt item: #189 of 440 id: cord-266935-bkan3mwy author: Giannakoulis, Vassilis G. title: Effect of Cancer on Clinical Outcomes of Patients With COVID-19: A Meta-Analysis of Patient Data date: 2020-06-08 words: 2883 flesch: 47 summary: An experience in Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in Iran: A single center study Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City Covid-19 testing, hospital admission, and intensive care among 2,026,227 United States Veterans aged 54-75 years Characteristics and outcomes of a cohort of SARS-CoV-2 patients in the Province of Reggio Emilia Clinical characteristics of imported and second-generation COVID-19 cases outside Wuhan, China: A multicenter retrospective study Clinical features and treatment of COVID-19 patients in northeast Chongqing Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical features of 69 cases with coronavirus disease Clinical characteristics of coronavirus disease 2019 in Hainan Retrospective study of risk factors for severe SARS-Cov-2 infections in hospitalized adult patients Clinical features and outcomes of 221 patients with COVID-19 in Wuhan Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city Clinical characteristics and durations of hospitalized patients with COVID-19 in Beijing: A retrospective cohort study A multicentre study of 2019 novel coronavirus disease outcomes of cancer patients in Wuhan Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China Clinical characteristics and prognosis in cancer patients with COVID-19: Patients with cancer were more likely to need ICU admission than patients without cancer (3,220 events; RR, 1.56; 95% CI, 1.31 to 1.87; P , .0001; Fig 3) . keywords: cancer; clinical; covid-19; mortality; patients; studies cache: cord-266935-bkan3mwy.txt plain text: cord-266935-bkan3mwy.txt item: #190 of 440 id: cord-267237-wbwlfx7q author: Gómez-Rial, Jose title: Increased Serum Levels of sCD14 and sCD163 Indicate a Preponderant Role for Monocytes in COVID-19 Immunopathology date: 2020-09-23 words: 2592 flesch: 33 summary: Pearson's correlation coefficients were used to quantify the association between sCD14 and sCD163 concentration and other lab parameters in non-ICU patients. ng/ml in non-ICU patients. keywords: covid-19; icu; levels; monocyte; patients; scd14; scd163 cache: cord-267237-wbwlfx7q.txt plain text: cord-267237-wbwlfx7q.txt item: #191 of 440 id: cord-267296-u4svwcpt author: Rauch, Antoine title: Endotheliopathy Is Induced by Plasma From Critically Ill Patients and Associated With Organ Failure in Severe COVID-19 date: 2020-11-10 words: 1326 flesch: 24 summary: As a positive control for endothelial cell injury, Shigatoxin 145 (Sigma-Aldrich, Saint Quentin Fallavier, France) was spiked in plasma from healthy adults (10 µg/mL final concentration) and incubated at 37°C for 15 minutes,before addition to HPMVECs. Different pathways could be involved in endothelial cell injury during the course of COVID-19, ie, complement activation, cellular hypoxia, platelets, and direct cytotoxicity of cytokines such as IL-6, IL-1β, and tumor necrosis factor-α. keywords: covid-19; endothelial; icu; patients; plasma cache: cord-267296-u4svwcpt.txt plain text: cord-267296-u4svwcpt.txt item: #192 of 440 id: cord-267373-nzxbogga author: Antinori, Spinello title: Compassionate remdesivir treatment of severe Covid-19 pneumonia in intensive care unit (ICU) and Non-ICU patients: Clinical outcome and differences in post_treatment hospitalisation status date: 2020-05-11 words: 3476 flesch: 43 summary: Eighteen patients started remdesivir in our ICU and seventeen in our Infectious Disease ward (IDW): most of ICU patients were undergoing invasive mechanical ventilation, and most of the IDW patients were undergoing high-flow oxygen therapy and/or non-invasive mechanical ventilation. r o o f blind clinical trial aimed at evaluating the efficacy and safety of remdesivir in hospitalised patients with mild to moderate COVID-19 respiratory disease keywords: cov-2; covid-19; icu; idw; patients; remdesivir; sars; treatment cache: cord-267373-nzxbogga.txt plain text: cord-267373-nzxbogga.txt item: #193 of 440 id: cord-268211-egy8rgtl author: Barrasa, Helena title: SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria date: 2020-04-09 words: 2691 flesch: 47 summary: Reports describing ICU patients with SARS-CoV-2 out of China are still limited [3, 4] . Early on this disease, non-intubated patients may benefit from prone position before intubation. keywords: cov-2; icu; intubation; mortality; non; patients; sars; ventilation cache: cord-268211-egy8rgtl.txt plain text: cord-268211-egy8rgtl.txt item: #194 of 440 id: cord-268254-1mg7a17c author: Liu, Li title: High neutralizing antibody titer in intensive care unit patients with COVID-19 date: 2020-07-20 words: 3480 flesch: 49 summary: Furthermore, by comparing ICU and non-ICU patients, we have shown that NAb response rose significantly earlier and to a much greater extent in severe patients than in mild patients. Furthermore, NAb titer increased significantly at earlier infection stages among ICU patients than among non-ICU patients. keywords: cov-2; covid-19; disease; icu; nab; patients; response; sars; titer cache: cord-268254-1mg7a17c.txt plain text: cord-268254-1mg7a17c.txt item: #195 of 440 id: cord-268662-mw8ec7u2 author: Salton, Francesco title: Prolonged low-dose methylprednisolone in patients with severe COVID-19 pneumonia date: 2020-09-12 words: 4410 flesch: 40 summary: No tracheostomy was necessary in MP patients vs. 12 controls (OR 0.04, 95% CI 0.002 to 0.64, p-value <0.001). [1] COVID-19 patients with ARF necessitate weeks of mechanical ventilation (MV) and have an unacceptably high mortality rate. keywords: covid-19; days; fio; icu; pao; patients; pneumonia; study; treatment cache: cord-268662-mw8ec7u2.txt plain text: cord-268662-mw8ec7u2.txt item: #196 of 440 id: cord-269914-75to9xr2 author: Jansson, Miia title: Artificial Intelligence for clinical decision support in Critical Care, required and accelerated by COVID-19 date: 2020-10-21 words: 1363 flesch: 25 summary: A Systematic Review Cardiorespiratory dynamics measured from continuous ECG monitoring improves detection of deterioration in acute care patients: a retrospective cohort study Predicting sequences of clinical events by using a personalized temporal latent embedding model Optimal intensive care outcome prediction over time using machine learning Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions Transfer Learning with Deep Convolutional Neural Network (CNN) for Pneumonia Detection using Chest X-ray Automated detection of COVID-19 cases using deep neural networks with X-ray images A systematic review of CT chest in COVID-19 diagnosis and its potential application in a surgical setting A new role for Biofoundries in rapid prototyping, development, and validation of automated clinical diagnostic tests for SARS-CoV-2 Robot-assisted therapy using the MOTOmed letto 2 for the integrated early rehabilitation of stroke patients admitted to the intensive care unit Current utilization and future directions of robotic-assisted endovascular surgery Automated tracheal intubation in an airway manikin using a robotic endoscope: a proof of concept study Diagnosis of ventilator-associated pneumonia using electronic nose sensor array signals: solutions to improve the application of machine learning in respiratory research 1+ Million Genomes Initiative Determinantes Genéticos y Biomarcadores genómicos de riesgo en pacientes con infección por coronavirus SARS-COV-2 Using whole genome sequencing to help combat COVID-19 Digi-HTA: Health technology assessment framework for digital healthcare services The clinical artificial intelligence department: a prerequisite for success AI, big data, and machine learning can help health care systems respond to these unprecedented challenges. keywords: care; covid-19; learning; models; patients; prediction cache: cord-269914-75to9xr2.txt plain text: cord-269914-75to9xr2.txt item: #197 of 440 id: cord-270628-jtj30v0r author: Alharthy, Abdulrahman title: Prospective Longitudinal Evaluation of Point‐of‐Care Lung Ultrasound in Critically Ill Patients With Severe COVID‐19 Pneumonia date: 2020-08-14 words: 4261 flesch: 41 summary: Is there a role for lung ultrasound during the COVID-19 pandemic? Proposal for international standardization of the use of lung ultrasound for COVID-19 patients; a simple, quantitative, reproducible method Point-of-care lung ultrasound in patients with COVID-19: a narrative review It's not over until it's over: the chameleonic behavior of COVID-19 over a six-day period COVID-19 outbreak: less stethoscope, more ultrasound Extension of coronavirus disease 2019 (COVID-19) on chest CT and implications for chest radiograph interpretation Relevance of lung ultrasound in the diagnosis of acute respiratory failure Bedside ultrasound assessment of positive end-expiratory pressureinduced lung recruitment Training for lung ultrasound score measurement in critically ill patients Ultrasound of the lungs more than a room with a view Ultrasonography for the assessment of lung recruitment maneuvers Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress Inter-rater reliability of quantifying pleural B-lines using multiple counting methods Diagnostic accuracy of chest radiograph, and when concomitantly studied lung ultrasound, in critically ill patients with respiratory symptoms: a systematic review and meta-analysis Lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia: a prospective, multicenter, diagnostic accuracy study Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2 Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT Clinical and high-resolution CT features of the COVID-19 infection: comparison of the initial and follow-up changes Proposal of a low-dose, long-pitch, dual-source chest CT protocol on third-generation dual-source CT using a tin filter for spectral shaping at 100 kVp for coronavirus disease 2019 (COVID-19) patients: a feasibility study Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding China Medical Treatment Expert Group for COVID-19. World Federation for Ultrasound in Medicine and Biology position statement: how to perform a safe ultrasound examination and clean equipment in the context of COVID-19 Lower-extremity Doppler for deep venous thrombosis: can emergency physicians be accurate and fast? Accuracy of ultrasonography performed by critical care physicians for the diagnosis of DVT Incidence of thrombotic complications in critically ill ICU patients with COVID-19 ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Autopsy findings and venous thromboembolism in patients with COVID-19 Post-mortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Severe pulmonary embolism in COVID-19 patients: a call for increased awareness Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study Acute kidney injury in the intensive care unit according to RIFLE Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention A trial of lopinavir-ritonavir in adults hospitalized with Severe COVID-19 Sonographic signs and patterns of COVID-19 pneumonia. keywords: admission; coronavirus; covid-19; findings; icu; lung; patients; pneumonia; pocus; study; ultrasound cache: cord-270628-jtj30v0r.txt plain text: cord-270628-jtj30v0r.txt item: #198 of 440 id: cord-270837-xvauo76d author: Hui, David S. title: The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors date: 2005-10-31 words: 5832 flesch: 46 summary: Tests of data quality, scaling assumptions, and reliability across diverse patient groups Tests of scaling assumptions and construct validity of the Chinese (HK) version of the SF 36 health survey Population based norming of the Chinese (HK) version of the SF 36 health survey Standardization of spirometry, 1994 update Lung function testing: selection of reference values and interpretative strategies Pulmonary function studies in healthy Chinese adults in Singapore Maximal respiratory pressures: normal values and relationships to age and sex Statement on respiratory muscle testing Comparison of two different mouthpieces for the measurement of Pimax and Pemax in normal and weak subjects Transdiaphragmatic pressure in young adult Singaporean subjects-normal values and a comparison between different respiratory manoeuvres Respiratory muscles Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients Reference equations for the sixminute walk in healthy adults Treatment of severe acute respiratory syndrome Severe acute respiratory syndrome: epidemiology, diagnosis and treatment Thin section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease Lung pathology of fatal severe acute respiratory syndrome The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS) Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors Severe acute respiratory syndrome: thin-section computed tomography features, temporal changes and clinico-radiological correlation during convalescent period Dynamic changes of serum SARS-coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge Long-term follow-up and bronchial reactivity testing in survivors of the adult respiratory distress syndrome Pulmonary function following the adult respiratory distress syndrome Clinical determinants of abnormalities in pulmonary functions in survivors of the adult respiratory distress syndrome Radiological and pulmonary function outcomes of children with SARS Long-term follow-up of survivors of acute lung injury: lack of effect of a ventilation strategy to prevent barotraumas Left ventricular performance in patients with severe acute respiratory syndrome: a 30 day echocardiographic follow-up study The impact of severe acute respiratory syndrome on the physical profile and quality of life in a cohort of survivors Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids Weakness of respiratory and skeletal muscles after a short course of steroids in patients with acute lung rejection Acute steroidinduced tetraplegia following status asthmaticus Neuromuscular disorders in severe acute respiratory syndrome Stress and psychological impact on SARS patients during the outbreak Psychiatric complications in patients with severe acute respiratory syndrome (SARS) during the acute treatment phase: a series of 10 cases Factors associated with psychosis among patients with severe acute respiratory syndrome: a case-control study ACKNOWLEDGMENT: We thank the following colleagues who have provided help in this ongoing study: M. Tong, RN; P.Y. Chan, RN; M.S. Cheng, RN; T.Y. Cheong, RN; M.Y. Leung; EN; E Lee (clerk); and C Ho (research assistant). These results suggest that the inability to exercise in recovered SARS patients is primarily due to extrapulmonary causes such as physical deconditioning and possibly steroid myopathy. keywords: acute; dlco; function; lung; months; patients; sars; study; survivors; syndrome cache: cord-270837-xvauo76d.txt plain text: cord-270837-xvauo76d.txt item: #199 of 440 id: cord-271146-levsbye2 author: Almuabbadi, Basel title: Novel transportation capsule technology could reduce the exposure risk to SARS-CoV-2 infection among healthcare workers: A feasibility study date: 2020-07-22 words: 345 flesch: 39 summary: Also, 109 HCWs were employed for the transportation of COVID-19 patients: 39 physicians, 20 respiratory physiotherapists, 20 ICU nurses, and 30 paramedics (Fig. 1) . In conclusion, the insulated patient capsule has proven to be an efficient technology for the transportation of COVID-19 patients. keywords: patients; transportation cache: cord-271146-levsbye2.txt plain text: cord-271146-levsbye2.txt item: #200 of 440 id: cord-271536-pscw933i author: Guo, Zhen-Dong title: Aerosol and Surface Distribution of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospital Wards, Wuhan, China, 2020 date: 2020-07-17 words: 1688 flesch: 56 summary: Furthermore, we found that rates of positivity differed by air sampling site, which reflects the distribution of virus-laden aerosols in the wards ( Figure 2 , panel A). Contamination was greater in intensive care units than general wards. keywords: air; area; dressing; icu; room cache: cord-271536-pscw933i.txt plain text: cord-271536-pscw933i.txt item: #201 of 440 id: cord-272314-6suu8n75 author: Hetland, Breanna title: 2020 - The Year that Needed the Nurse: Considerations for Critical Care Nursing Research and Practice Emerging in the Midst of COVID-19 date: 2020-05-03 words: 1288 flesch: 34 summary: The high acuity of ICU patients with COVID-19 coupled with burgeoning unit census brought a common challenge faced by critical care nurses into sharp focus: the extreme difficulty in providing humanistic integrated patient and family centered care to our sickest ICU patients. Critical care nurses are on the frontlines, shouldering the heavy burden of managing the 'sickest of the sick' patients who are in need of life-saving mechanical ventilatory support. keywords: care; covid-19; patients; research cache: cord-272314-6suu8n75.txt plain text: cord-272314-6suu8n75.txt item: #202 of 440 id: cord-272349-cqzfjg5t author: De Lorenzo, Antonino title: Fat mass affects nutritional status of ICU COVID-19 patients date: 2020-08-03 words: 3724 flesch: 42 summary: This is the first study evaluating FM% in COVID-19 patient. Despite the relationship between FM% and severity of progression inflammatory response in patients admitted to ICU for underlying infective disease, there are no available data on the relevance of FM% in COVID-19 patients treated in ICU. keywords: bmi; body; covid-19; fat; fm%; icu; nutritional; obese; obesity; patients; response cache: cord-272349-cqzfjg5t.txt plain text: cord-272349-cqzfjg5t.txt item: #203 of 440 id: cord-273350-b2exkw6x author: Soh, Mitsuhito title: Impaired mental health status following ICU care in a patient with COVID‐19 date: 2020-08-11 words: 1330 flesch: 45 summary: key: cord-273350-b2exkw6x authors: Soh, Mitsuhito; Hifumi, Toru; Iwasaki, Tsutomu; Miura, Yusuke; Otani, Norio; Ishimatsu, Shinichi title: Impaired mental health status following ICU care in a patient with COVID‐19 date: 2020-08-11 journal: Acute Med Surg DOI: 10.1002/ams2.562 sha: doc_id: 273350 cord_uid: b2exkw6x BACKGROUND: Severe respiratory failure patients with coronavirus disease 2019 (COVID‐19) sometimes do not receive post intensive care syndrome prevention bundles. Here, we report a COVID-19 case that developed an impaired mental health status following intensive care unit ICU care. keywords: care; covid-19; icu; patients cache: cord-273350-b2exkw6x.txt plain text: cord-273350-b2exkw6x.txt item: #204 of 440 id: cord-273737-t6j3leec author: Poeran, Jashvant title: Cancellation of Elective Surgery and Intensive Care Unit Capacity in New York State: A Retrospective Cohort Analysis date: 2020-06-30 words: 2286 flesch: 46 summary: Overall, ICU admissions in New York State were seen in 10.1% of all hospitalizations (n = 1,232,986/n = 12,251,617) and remained stable over a 5-year period from 2011 to 2015. Among n = 1,232,986 ICU stays, sources of ICU admission included elective surgery (13.4%, n = 165,365), emergent/urgent admissions/trauma surgery (28.0%, n = 345,094), and medical admissions (58.6%, n = 722,527). keywords: admissions; icu; surgery; trauma cache: cord-273737-t6j3leec.txt plain text: cord-273737-t6j3leec.txt item: #205 of 440 id: cord-275445-d3i12m3l author: Hashmi, Madiha title: A national survey of critical care services in hospitals accredited for training in a lower-middle income country: Pakistan date: 2020-08-21 words: 3294 flesch: 44 summary: Investment in critical care training for doctors and nurses is needed. Investment in critical care training for doctors and nurses is needed. keywords: access; care; icus; pakistan; services; training; units cache: cord-275445-d3i12m3l.txt plain text: cord-275445-d3i12m3l.txt item: #206 of 440 id: cord-275457-buq2d4k2 author: Jannes, G. title: Beta regression with spatio-temporal effects as a tool for hospital impact analysis of initial phase epidemics: the case of COVID-19 in Spain date: 2020-06-29 words: 8350 flesch: 52 summary: In this article, we have discussed how these can be complemented through the use of Beta distribution and regression models. The paper therefore develops distribution models for both Spain globally (in the main text) and for its regions separately (in the Appendices). keywords: beta; cases; data; distribution; hosp; icu; license; model; patients; preprint; ratios; regression cache: cord-275457-buq2d4k2.txt plain text: cord-275457-buq2d4k2.txt item: #207 of 440 id: cord-275838-un11s2mr author: Levy, Jonathan title: A model for a ventilator-weaning and early rehabilitation unit to deal with post-ICU impairments with severe COVID-19 date: 2020-04-18 words: 866 flesch: 46 summary: It also allows for a physical medicine and rehabilitation holistic evaluation of post-critical COVID-19 patients. The pavilion architecture of our hospital allowed us to secure 2 buildings for COVID-19-free patients (from the conventional ICU and infectious diseases and neurorehabilitation units) and isolate one building for COVID-19 patients ( Each bed is equipped with a level-3 life support ventilator Astral 150® (ResMed, San Diego, CA, USA) and non-invasive continuous monitoring (oxygen saturation, heart rate, noninvasive blood pressure). keywords: covid-19; icu; patients cache: cord-275838-un11s2mr.txt plain text: cord-275838-un11s2mr.txt item: #208 of 440 id: cord-276181-5gh0i394 author: Eimer, J. title: Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: a retrospective cohort study. date: 2020-07-30 words: 1553 flesch: 41 summary: Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region Abnormal pulmonary function in COVID-19 patients at time of hospital discharge Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia Effective treatment of severe COVID-19 patients with tocilizumab Long-term complications of critical care Costs of Providing Infusion Therapy for Rheumatoid Arthritis in a Hospital-based Infusion Center Setting Alternate corresponding author / proof reader Senior Consultant in Infectious Diseases Phone None. key: cord-276181-5gh0i394 authors: Eimer, J.; Vesterbacka, J.; Svensson, A.-K.; Stojanovic, B.; Wagrell, C.; Sonnerborg, A.; Nowak, P. title: Tocilizumab shortens time on mechanical ventilation and length of hospital stay in patients with severe COVID-19: a retrospective cohort study. keywords: covid-19; patients; tocilizumab cache: cord-276181-5gh0i394.txt plain text: cord-276181-5gh0i394.txt item: #209 of 440 id: cord-276359-syr9av09 author: Piva, Simone title: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy date: 2020-04-14 words: 3316 flesch: 47 summary: CONCLUSIONS: ICU patients with COVID-19 frequently have hypertension. This is the first reported cohort of ICU patients with COVID-19 from the Lombardy region. keywords: covid-19; icu; non; patients; physicians; scale; therapies; ventilation cache: cord-276359-syr9av09.txt plain text: cord-276359-syr9av09.txt item: #210 of 440 id: cord-276374-i37ygb2z author: Deasy, Jacob title: Forecasting ultra-early intensive care strain from COVID-19 in England date: 2020-03-23 words: 2981 flesch: 44 summary: By incorporating a 'delay to ICU' parameter within our model, that can take on negative values (thus indicating a diagnosis after ICU admission), we hope to have replicated the anecdotal experience of clinicians in these early phases of the pandemic; that a substantial proportion of patients are being con- forecast numbers as these data inform our standardised estimates of ICU cases from within each population [9] . Figure 2: Regional demographics and expected critical care demand per case of COVID-19, stratified by region and compared to ICU bed capacity per 100,000 people. keywords: capacity; cases; covid-19; data; icu; model; time cache: cord-276374-i37ygb2z.txt plain text: cord-276374-i37ygb2z.txt item: #211 of 440 id: cord-276676-lgt0rzob author: Moka, Eleni title: Best Practice in Cardiac Anesthesia during the COVID-19 Pandemic: Practical Recommendations date: 2020-07-03 words: 5885 flesch: 31 summary: Strict measures and precautions for infection control should be implanted and must definitely be applied in the case of suspected/ confirmed COVID-19 cardiac surgery patients Cardiac surgery patients must always wear a N95/surgical mask, and at all times, and should be transported to the OR through a predesigned pathway. keywords: anesthesia; blood; cardiac; care; cases; coronavirus; covid-19; disease; equipment; health; infection; operations; pandemic; patients; surgery cache: cord-276676-lgt0rzob.txt plain text: cord-276676-lgt0rzob.txt item: #212 of 440 id: cord-276782-3fpmatkb author: Garbey, M. title: A Model of Workflow in the Hospital During a Pandemic to Assist Management date: 2020-05-02 words: 5720 flesch: 56 summary: The hospital system needs to recruit resources quickly 349 enough to deliver quality patient care while keeping the staff safe from infection. On the hospital workflow side, while there is a large amount of work on this 27 topic [23] , one of the difficulties is to asses the death rate of patients hospitalized at the 28 beginning of the pandemic because the Length of stay (LOS) is rather long and the 29 disease is still not well understood [2, 16, 26] . keywords: care; hospital; license; model; number; patients; preprint; unit cache: cord-276782-3fpmatkb.txt plain text: cord-276782-3fpmatkb.txt item: #213 of 440 id: cord-276808-sax7qc85 author: Rosas, I. title: Tocilizumab in Hospitalized Patients With COVID-19 Pneumonia date: 2020-09-01 words: 5004 flesch: 36 summary: Coronavirus disease (COVID-19) pandemic Clinical characteristics of coronavirus disease 2019 in China Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Immunology of COVID-19: current state of the science Complex immune dysregulation in COVID-19 patients with severe respiratory failure Elevated interleukin-6 and severe COVID-19: a metaanalysis Endothelial cell infection and endotheliitis in COVID-19 Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection A review of recent advances using tocilizumab in the treatment of rheumatic diseases Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab CONCLUSIONS In this randomized placebo-controlled trial in hospitalized COVID-19 pneumonia patients, tocilizumab did not improve clinical status or mortality. keywords: copyright holder; license; medrxiv preprint; peer review; preprint; september; version cache: cord-276808-sax7qc85.txt plain text: cord-276808-sax7qc85.txt item: #214 of 440 id: cord-276952-nkaow79h author: Sim, Starling A. title: Viral Respiratory Tract Infections in Allogeneic Hematopoietic Stem Cell Transplantation Recipients in the Era of Molecular Testing date: 2018-03-09 words: 3690 flesch: 42 summary: Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center Respiratory viral infections after bone marrow/peripheral stem-cell transplantation: the Christie Hospital experience Respiratory virus infections after stem cell transplantation: a prospective study from the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Respiratory virus infections in adults with hematologic malignancies: a prospective study Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Community respiratory virus infections in bone marrow transplant recipients: the M.D. Anderson Cancer Center experience Respiratory virus infections in bone marrow transplant recipients: the European perspective Prospective study of the incidence, clinical features, and outcome of symptomatic upper and lower respiratory tract infections by respiratory viruses in adult recipients of hematopoietic stem cell transplants for hematologic malignancies Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients Real-time RT-PCR detection of 12 respiratory viral infections in four triplex reactions Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4 The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting Centre for International Blood and Marrow Transplant Research. Form Instruction Manual ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients Viral respiratory infections diagnosed by multiplex PCR after allogeneic hematopoietic stem cell transplantation: long-term incidence and outcome Rhinovirus infections in hematopoietic stem cell transplant recipients with pneumonia respiratory syncytial virus: infection, detection, and new options for prevention and treatment CD4+ T lymphocyte counts after autologous transplantation in multiple myeloma: a retrospective study Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections Prospective study of respiratory viral infections in pediatric hemopoietic stem cell transplantation patients Respiratory virus infections in transplant recipients after reduced-intensity conditioning with Campath-1H: high incidence but low mortality Symptomatic parainfluenza virus infections in children undergoing hematopoietic stem cell transplantation The clinical features and outcome of 2009 H1N1 influenza infection in allo-SCT patients: a British Society of Blood and Marrow Transplantation study Outcome of influenza infections in outpatients after allogeneic hematopoietic stem cell transplantation Infections with the 2009 H1N1 influenza virus among hematopoietic SCT recipients: a single center experience Respiratory syncytial virus infection in recipients of allogeneic stem-cell transplantation: a retrospective study of the incidence, clinical features, and outcome The human immune response to respiratory syncytial virus infection Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients keywords: days; hsct; infection; patients; risk; study; transplantation; vrti cache: cord-276952-nkaow79h.txt plain text: cord-276952-nkaow79h.txt item: #215 of 440 id: cord-277248-7qnymo98 author: dos Reis, Helena Lucia Barroso title: Severe coronavirus infection in pregnancy: challenging cases report date: 2020-07-13 words: 2812 flesch: 44 summary: This study reports three cases of COVID-19 comprising pregnant women with severe respiratory failure and evaluates the clinical management of COVID-19 infection in obstetric clinics in Vitoria, Espirito Santo State, Brazil. A novel coronavirus from patients with pneumonia in China Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases Maternal deaths with coronavirus disease 2019: a different outcome from lowto middle-resource countries? Serial interval of COVID-19 among publicly reported confirmed cases COVID-19 infection among asymptomatic and symptomatic pregnant women: Two weeks of confirmed presentations to an affiliated pair of New York City hospitals An analysis of 38 Pregnant women with COVID-19, their newborn infants, and maternal-fetal transmission of SARS-CoV-2: maternal coronavirus infections and pregnancy outcomes Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia A case report of neonatal COVID-19 infection in China Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue Chloroquine and hydroxychloroquine during pregnancy: what do we know? keywords: cases; covid-19; day; days; infection; women cache: cord-277248-7qnymo98.txt plain text: cord-277248-7qnymo98.txt item: #216 of 440 id: cord-277621-mvsdrxzf author: Canavera, Kristin title: Mental Health Care During and After the ICU: A Call to Action date: 2020-06-27 words: 983 flesch: 40 summary: Despite this data, patients often do not receive mental health care during or after their ICU admission in our country. Even prior to the COVID-19 pandemic, our country had an unmet yet important need to improve our provision of mental health care for critically ill patients and ICU survivors. keywords: care; icu cache: cord-277621-mvsdrxzf.txt plain text: cord-277621-mvsdrxzf.txt item: #217 of 440 id: cord-277879-7ftu9b9q author: Martinez-Sanz, J. title: Effects of Tocilizumab on Mortality in Hospitalized Patients with COVID-19: A Multicenter Cohort Study date: 2020-06-09 words: 4021 flesch: 39 summary: Tocilizumab targets the IL-6 receptor, and thus using baseline IL-6 levels instead of CRP in the interaction term with tocilizumab use could have helped to better discriminate the population benefiting most from tocilizumab treatment. 5 Tocilizumab is not currently approved for use by the FDA in COVID-19 patients. keywords: covid-19; crp; death; license; medrxiv; patients; preprint; tocilizumab cache: cord-277879-7ftu9b9q.txt plain text: cord-277879-7ftu9b9q.txt item: #218 of 440 id: cord-278325-ykcd7d59 author: Cheung, Carmen Ka Man title: Coronavirus Disease 2019 (COVID-19): A Haematologist's Perspective date: 2020-07-28 words: 7682 flesch: 35 summary: Thrombocytopenia, coagulation abnormalities, and disseminated intravascular coagulation were observed in COVID-19 patients, especially those with critical illness and non-survivors. [45] evaluated lymphocyte subsets in 103 patients, which revealed that CD3+, CD4+, and CD8+ T cells and NK cells were significantly decreased in COVID-19 patients with a more severe decrease in CD8+ T cells compared with CD4+ T cells. keywords: admission; blood; cells; clinical; coronavirus; cov-2; covid-19; disease; infection; lymphocyte; non; patients; platelet; risk; sars; study; treatment cache: cord-278325-ykcd7d59.txt plain text: cord-278325-ykcd7d59.txt item: #219 of 440 id: cord-278638-2dm54f6l author: Huang, Ian title: Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis date: 2020-05-24 words: 3107 flesch: 46 summary: Regressionbased Harbord's test showed no evidence of small-study effects (p = 0.086) for lymphopenia and severe COVID-19 outcome. Lymphocyte count has been a marker of interest since the first COVID-19 publication. keywords: analysis; count; covid-19; lymphocyte; meta; outcome; patients cache: cord-278638-2dm54f6l.txt plain text: cord-278638-2dm54f6l.txt item: #220 of 440 id: cord-278838-qraq5aho author: Mirouse, Adrien title: Severe varicella-zoster virus pneumonia: a multicenter cohort study date: 2017-06-07 words: 4705 flesch: 40 summary: Patients receiving steroids were matched in a 1:6 ratio to a control group of patients within this cohort who did not receive steroids. Patients receiving steroids were matched in a 1:6 ratio to a control group of patients within this cohort who did not receive steroids. keywords: admission; cap; icu; infection; patients; pneumonia; steroids; study; ventilation; vzv cache: cord-278838-qraq5aho.txt plain text: cord-278838-qraq5aho.txt item: #221 of 440 id: cord-278993-w5aa0elj author: Tonetti, Tommaso title: Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy date: 2020-10-12 words: 3929 flesch: 37 summary: In patients treated outside the ICU, conventional O 2 therapy was applied in the 47.3% of the cases and non-invasive respiratory support (including NIV, CPAP and high-flow O 2 therapy) in the 52.7%, while 81.8% of ICU patients were intubated. Data regarding the impact of Covid-19 outbreak on the capacity of the health-care system to accomplish the need for ICU care are limited. keywords: beds; care; covid-19; data; icu; italy; non; outbreak; patients; resources; study; support cache: cord-278993-w5aa0elj.txt plain text: cord-278993-w5aa0elj.txt item: #222 of 440 id: cord-279520-zccd1mq5 author: Christian, Michael D. title: Possible SARS Coronavirus Transmission during Cardiopulmonary Resuscitation date: 2004-02-17 words: 4053 flesch: 39 summary: Of particular concern are procedures performed on SARS patients that may aerosolize SARS-CoV and lead to limited airborne transmission or enhanced contact and droplet transmission (9) . On the basis of the results of this investigation and previous reports of SARS transmission during aerosol-generating procedures, a systematic approach to the problem is outlined, including the use of the following: 1) administrative controls, 2) environmental engineering controls, 3) personal protective equipment, and 4) quality control. keywords: control; equipment; healthcare; patient; protection; resuscitation; sars; transmission; workers cache: cord-279520-zccd1mq5.txt plain text: cord-279520-zccd1mq5.txt item: #223 of 440 id: cord-280942-ej8fx52u author: Daunizeau, J. title: On the reliability of model-based predictions in the context of the current COVID epidemic event: impact of outbreak peak phase and data paucity date: 2020-04-29 words: 5645 flesch: 47 summary: In this work, we show that peak phase and data paucity have a substantial impact on the reliability of model predictions. Also, model predictions may depend sensitively upon the current phase of the epidemic event: more precisely, whether the outbreak peak has been reached or not (Lin et al., 2020) . keywords: data; icu; license; model; peak; preprint; rates; test cache: cord-280942-ej8fx52u.txt plain text: cord-280942-ej8fx52u.txt item: #224 of 440 id: cord-282958-9bi6pobg author: Ganem, Fabiana title: The impact of early social distancing at COVID-19 Outbreak in the largest Metropolitan Area of Brazil. date: 2020-04-08 words: 1678 flesch: 47 summary: The copyright holder for this preprint . confirmed COVID-19 cases between 26 th February and 30 th March. To tackle the spread of disease, a range of interventions have been implemented in China, including increasing test capacity, rapid isolation of suspected and confirmed cases and their contacts, social distancing measures, as well as restricting mobility (6) . keywords: cases; covid-19; license; preprint cache: cord-282958-9bi6pobg.txt plain text: cord-282958-9bi6pobg.txt item: #225 of 440 id: cord-283780-h4lwzpl9 author: Zhang, John J Y title: Risk Factors of Severe Disease and Efficacy of Treatment in Patients Infected with COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression Analysis date: 2020-05-14 words: 3122 flesch: 43 summary: At baseline, the quality of evidence derived from a review of COVID-19 studies was assessed as low, owing to their observational nature. The quality of included studies was assessed using the Joanna Briggs Institute (JBI) checklist for prevalence studies and the JBI checklist for case series [10] . keywords: analysis; covid-19; meta; patients; studies cache: cord-283780-h4lwzpl9.txt plain text: cord-283780-h4lwzpl9.txt item: #226 of 440 id: cord-284177-otr38534 author: Wax, Randy S. title: Preparing the Intensive Care Unit for Disaster date: 2019-08-21 words: 4583 flesch: 26 summary: Given that critical care is by nature an interprofessional health care effort, the need for interprofessional involvement in critical care disaster planning should be obvious. Table 2 highlights potential contributions of different stakeholders toward critical care disaster planning, with further details discussed below. keywords: care; critical; disaster; event; hospital; icu; patients; planning; preparedness; specific; staff; support cache: cord-284177-otr38534.txt plain text: cord-284177-otr38534.txt item: #227 of 440 id: cord-284417-pmn6ll1q author: Mulet Bayona, Juan V. title: Characteristics and Management of Candidaemia Episodes in an Established Candida auris Outbreak date: 2020-08-30 words: 4240 flesch: 43 summary: The epidemiology of those patients with candidaemia and the susceptibility of C. auris isolates are also reported. Antifungal susceptibility of C. auris isolates is reported in Table 2 . keywords: auris; candidaemia; icu; outbreak; patients; species cache: cord-284417-pmn6ll1q.txt plain text: cord-284417-pmn6ll1q.txt item: #228 of 440 id: cord-284526-a5kgo4ct author: Gavriilaki, Eleni title: Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses date: 2020-08-27 words: 6013 flesch: 26 summary: Translational lessons from animal models Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Clin Microbiol Infect: the official publication of the European Society of Clinical Microbiology and Infectious Diseases COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features A first case of meningitis/encephalitis associated with SARS-Coronavirus-2 Acute disseminated encephalomyelitis after SARS-CoV-2 infection Severe COVID-19 infection and thrombotic microangiopathy: success does not come easily A case-series study describing a possible pathophysiologic mechanism of severe COVID-19 infection unravelled the catastrophic microvascular injury syndrome mediated by complement cascade Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Autopsy findings and venous thromboembolism in patients with COVID-19 Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Pulmonary embolism in COVID-19 patients: awareness of an increased prevalence Incidence of venous thromboembolism in hospitalized patients with COVID-19 High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum Scientific and standardization committee communication: clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID In parallel with autopsy findings, high rates of VTE (10 to 43%, especially PE) have been clinically diagnosed in COVID-19 patients in intensive care units (ICUs) keywords: acute; case; coronavirus; covid-19; disease; dysfunction; endothelial; icu; infection; patients; sars; study; syndrome cache: cord-284526-a5kgo4ct.txt plain text: cord-284526-a5kgo4ct.txt item: #229 of 440 id: cord-284883-bkydu285 author: Luis Silva, L. title: Brazil Health Care System preparation against COVID-19 date: 2020-05-13 words: 4501 flesch: 46 summary: To evaluate the geographical accessibility to emergency care service care was used the two-step floating catchment area (2SFCA) technique. Once the EII was computed, and the municipalities with high incidence within regions with low access to emergency care services care were identified, a Getis-Ord-Gi analysis was performed. keywords: beds; brazil; care; country; covid-19; emergency; health; icu; license; preprint; regions cache: cord-284883-bkydu285.txt plain text: cord-284883-bkydu285.txt item: #230 of 440 id: cord-285291-pep4opiq author: Remy, Kenneth E. title: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists* date: 2020-04-29 words: 7169 flesch: 29 summary: Part 2: Treatment Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report Treatment of acute pulmonary embolism: Update on newer pharmacologic and interventional strategies guidelines for management of venous thromboembolism: Prophylaxis for hospitalized and nonhospitalized medical patients Clinical Guidelines Committee of the American College of Physicians: Venous thromboembolism prophylaxis in hospitalized patients: A clinical practice guideline from the American College of Physicians Diagnosis of gastrointestinal bleeding: A practical guide for clinicians PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group: Effect of stress ulcer prophylaxis with proton pump inhibitors vs histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation: The PEPTIC randomized clinical trial Hyperglycemic crises in adult patients with diabetes Hyperosmolar hyperglycemic state: A historic review of the clinical presentation, diagnosis, and treatment Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients Acute renal impairment in coronavirus-associated severe acute respiratory syndrome SMART Investigators and the Pragmatic Critical Care Research Group: Balanced crystalloids versus saline in critically ill adults Delirium in the critically ill patient Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU ICU delirium -a diagnostic and therapeutic challenge in the intensive care unit Sedation and delirium in the intensive care unit Incidence and prevalence of pressure injuries in adult intensive care patients: A systematic review and meta-analysis Risk factors for pressure injury development in critically ill patients in the intensive care unit: A systematic review protocol ICU-acquired weakness and recovery from critical illness Critical illness polyneuropathy and myopathy: A major cause of muscle weakness and paralysis Critical illness myopathy and neuropathy Pressure injury risk factors in adult critical care patients: A review of the literature Effectiveness of pressure ulcer prevention strategies for adult patients in intensive care units: A systematic review Treatment of pressure ulcers: A systematic review Management of acute alcohol withdrawal syndrome in critically ill patients Approach to the complicated alcohol withdrawal patient The use of dexmedetomidine as an adjuvant to benzodiazepine-based therapy to decrease the severity of delirium in alcohol withdrawal in adult intensive care unit patients: A systematic review Proxy decision making for incompetent patients. Acute decompensated heart failure (ADHF) is one of the main causes of respiratory distress in adult patients requiring the ICU (99) . keywords: acute; adults; care; covid-19; disease; distress; failure; heart; icu; management; mortality; patients; pressure; sedation; syndrome; treatment; trial; use; ventilation cache: cord-285291-pep4opiq.txt plain text: cord-285291-pep4opiq.txt item: #231 of 440 id: cord-285381-6e9umbpi author: Fort, Daniel title: Locally Informed Modeling to Predict Hospital and Intensive Care Unit Capacity During the COVID-19 Epidemic date: 2020 words: 2901 flesch: 42 summary: The model was deemed qualitatively valid and useful if the 10 days of subsequently observed census continued to track the model forecast, thereby allowing adequate time for initial expansion of ICU bed capacity. ICU bed capacity was also increased by 46 beds at community hospitals by opening a new ICU and converting operating rooms and parts of emergency departments to ICU beds. keywords: care; census; covid-19; hospital; icu; model; patients cache: cord-285381-6e9umbpi.txt plain text: cord-285381-6e9umbpi.txt item: #232 of 440 id: cord-286837-j2sqs20q author: Koetsier, Antonie title: Do Intensive Care Data on Respiratory Infections Reflect Influenza Epidemics? date: 2013-12-31 words: 4530 flesch: 45 summary: We explored whether ICU data reflect influenza like illness (ILI) activity in the general population, and whether ICU respiratory infections can predict influenza epidemics. In addition, ICU data of the first three years was used to build three regression models to predict the start and end of influenza epidemics in the years thereafter, one to three weeks ahead. keywords: admissions; data; epidemics; icu; ili; incidence; influenza; week cache: cord-286837-j2sqs20q.txt plain text: cord-286837-j2sqs20q.txt item: #233 of 440 id: cord-287102-o19uwryp author: Amit, Moran title: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study date: 2020-07-18 words: 4185 flesch: 48 summary: The following mortality rates have been found for Covid-19 patients in the ICU for whom outcome data are available (i.e., excluding patients who were still being treated in the ICU at the time of the report): 61% (Lombardy, Italy [2] ), 78% (New York City, NY, USA [4] ), 79% (Wuhan, China [11] ), 57% (Seattle, WA, USA [12] ), 85% (Washington state, USA [13] ), and 67% (China [3] )) Patients who died prior to ICU admission and patients without outcome data were excluded. keywords: age; covid-19; data; days; icu; israel; patients; years cache: cord-287102-o19uwryp.txt plain text: cord-287102-o19uwryp.txt item: #234 of 440 id: cord-287132-ellr5l4z author: Reif, Sarah Jordan title: A pilot volunteer reader programme decreases delirium days in critically ill, adult ICU patients date: 2020-07-20 words: 1572 flesch: 46 summary: ICU patients need to be maintained, as much as possible, with a normal sleep-wake cycle and with minimisation of social isolation to avoid the onset of delirium; this also could maintain their safety, comfort and overall physical and psychological function. An ICU Reader Programme appears to decrease risk for, and duration of, delirium in adult ICU patients. keywords: delirium; icu; patients; programme cache: cord-287132-ellr5l4z.txt plain text: cord-287132-ellr5l4z.txt item: #235 of 440 id: cord-287333-h89tmi0w author: Sanfilippo, Filippo title: The importance of a “socially responsible” approach during COVID-19: the invisible heroes of science in Italy date: 2020-05-26 words: 571 flesch: 36 summary: In summary, Italian ICU physicians avoided compulsory public notoriety, behaving as invisible heroes of science. Ironically, ICU physicians commented we desperately need football games back, so that millions of people become again football managers rather than COVID-19 experts! keywords: covid-19; icu cache: cord-287333-h89tmi0w.txt plain text: cord-287333-h89tmi0w.txt item: #236 of 440 id: cord-287468-e5h4tmy6 author: Lopez, Alexandre title: Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results date: 2020-08-08 words: 1990 flesch: 47 summary: The Surviving Sepsis Campaign guidelines on the management of Covid-19 patients concluded there was insufficient evidence to recommend the use of antiviral drugs and hydroxychloroquine in ICU patients [7] . The primary objective of our study was to assess the effects of hydroxychloroquine according to its plasma concentration in ICU patients. keywords: covid-19; hydroxychloroquine; icu; patients; plasma; target cache: cord-287468-e5h4tmy6.txt plain text: cord-287468-e5h4tmy6.txt item: #237 of 440 id: cord-287628-lzqsh3jf author: Gomersall, Charles D. title: Transmission of SARS to healthcare workers. The experience of a Hong Kong ICU date: 2006-02-25 words: 2611 flesch: 55 summary: It was a retrospective audit of the outcome of measures to prevent SARS infection amongst ICU staff. Duration of exposure to SARS patients was obtained from nursing and medical rosters. keywords: healthcare; icu; infection; patients; sars; staff cache: cord-287628-lzqsh3jf.txt plain text: cord-287628-lzqsh3jf.txt item: #238 of 440 id: cord-287732-abzpfdcu author: Martindale, Robert title: Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID‐19) date: 2020-05-27 words: 6234 flesch: 37 summary: Unless vasopressor dose is escalating and/or enteral feeding intolerance ensues (e.g. ileus, abdominal distention, vomiting), circulatory shock associated with SARS-CoV-2 should not be seen as a contraindication to trophic EN. 5 Early EN may not be preferred in a subset of COVID-19 patients with GI symptoms. Continuous postive pressure ventilation through helmet has been used exensively in Italy for COVID-19 patients, and nutition maybe provided more effectively and safely than mask NIPPV, but data are needed. keywords: article; care; copyright; covid-19; enteral; feeding; icu; nutrition; patients; recommendation; rights; risk; therapy cache: cord-287732-abzpfdcu.txt plain text: cord-287732-abzpfdcu.txt item: #239 of 440 id: cord-288222-8fqfbys2 author: Hardy, Michaël title: Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Study date: 2020-10-24 words: 1198 flesch: 37 summary: Published data so far are consistent with defective fibrinolysis in COVID-19 patients (which is not unique to this infectious condition), using viscoelastometric assays modified with tPA addition (5, 6, 9) . In light of these results and of the current knowledge on hemostasis disturbances of COVID-19 patients, we suggest that a close monitoring of a sensible set hemostatic parameters would be useful to assess individual thrombotic risk. keywords: covid-19; icu; levels; patients cache: cord-288222-8fqfbys2.txt plain text: cord-288222-8fqfbys2.txt item: #240 of 440 id: cord-288580-onzzpkye author: HALAÇLI, Burçin title: Critically ill COVID-19 patient date: 2020-04-21 words: 3808 flesch: 41 summary: For this purpose, elective in-patient admissions and surgeries should be delayed and available wards could be adapted for stepping down other ICU patients in order to evacuate ICUs. In this review, we aimed to emphasize the crucial points regarding intensive care management of COVID-19 patients, which we have written not only for intensivists but also for all healthcare professionals. keywords: care; coronavirus; covid-19; icu; intubation; patients; pneumonia; pressure; risk; ventilation cache: cord-288580-onzzpkye.txt plain text: cord-288580-onzzpkye.txt item: #241 of 440 id: cord-289188-hf9sh9vs author: Salazar, M. R. title: EFFECT OF CONVALESCENT PLASMA ON MORTALITY IN PATIENTS WITH COVID-19 PNEUMONIA date: 2020-10-09 words: 3055 flesch: 42 summary: Blood Transfus Treatment of COVID-19 with convalescent plasma: lessons from past coronavirus outbreaks The Emerging Role of Convalescent Plasma in the Treatment of COVID-19 Use of convalescent plasma therapy in SARS patients in Hong Kong Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: Our objective was to compare epidemiological characteristics and outcomes between patients who received convalescent plasma for COVID-19 and those who did not, admitted to hospitals in Buenos Aires Province, Argentina, throughout the pandemic. keywords: convalescent; license; medrxiv; patients; plasma; preprint cache: cord-289188-hf9sh9vs.txt plain text: cord-289188-hf9sh9vs.txt item: #242 of 440 id: cord-289304-9srk0ohb author: Bagnato, Sergio title: Critical illness myopathy after COVID-19 date: 2020-08-05 words: 1724 flesch: 40 summary: Since rehabilitation programs can be effective to reverse muscle weakness caused by CIM, health systems must plan to provide adequate access to rehabilitative facilities for patients requiring both pulmonary and motor rehabilitative treatment after COVID-19. key: cord-289304-9srk0ohb authors: Bagnato, Sergio; Boccagni, Cristina; Marino, Giorgio; Prestandrea, Caterina; D’Agostino, Tiziana; Rubino, Francesca title: Critical illness myopathy after COVID-19 date: 2020-08-05 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.07.072 sha: doc_id: 289304 cord_uid: 9srk0ohb We describe a patient who developed diffuse and symmetrical muscle weakness after a long stay in the intensive care unit (ICU) due to coronavirus disease 2019 (COVID-19). keywords: icu; muscle; patient; weakness cache: cord-289304-9srk0ohb.txt plain text: cord-289304-9srk0ohb.txt item: #243 of 440 id: cord-289550-b8f4a7o3 author: Neuwirth, C. title: Investigating duration and intensity of Covid-19 social-distancing strategies date: 2020-04-29 words: 3868 flesch: 48 summary: The Lancet COVID-19: Getting ahead of the epidemic curve by early implementation of social distancing Mathematical modeling of COVID-19 transmission and mitigation strategies in the population of Ontario The variability of critical care bed numbers in Europe Estimating the number of infections and the impact of non-pharmaceutical interventions on COVID-19 in 11 European countries The psychological impact of quarantine and how to reduce it: rapid review of the evidence. In this study, we present an exploratory and model-based systems analysis that is 29 aimed at investigating the application of social distancing strategies to Covid-19. keywords: april; care; covid-19; license; medrxiv; model; number; preprint cache: cord-289550-b8f4a7o3.txt plain text: cord-289550-b8f4a7o3.txt item: #244 of 440 id: cord-289973-1mczuxsy author: Biran, Noa title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date: 2020-08-14 words: 5219 flesch: 38 summary: Patients who received tocilizumab showed a reduction in Creactive protein levels at 3, 7, and 14 days after administration of tocilizumab compared with patients who did not receive tocilizumab. key: cord-289973-1mczuxsy authors: Biran, Noa; Ip, Andrew; Ahn, Jaeil; Go, Ronaldo C; Wang, Shuqi; Mathura, Shivam; Sinclaire, Brittany A; Bednarz, Urszula; Marafelias, Michael; Hansen, Eric; Siegel, David S; Goy, Andre H; Pecora, Andrew L; Sawczuk, Ihor S; Koniaris, Lauren S; Simwenyi, Micky; Varga, Daniel W; Tank, Lisa K; Stein, Aaron A; Allusson, Valerie; Lin, George S; Oser, William F; Tuma, Roman A; Reichman, Joseph; Brusco, Louis; Carpenter, Kim L; Costanzo, Eric J; Vivona, Vincent; Goldberg, Stuart L title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date: 2020-08-14 journal: The Lancet Rheumatology DOI: 10.1016/s2665-9913(20)30277-0 sha: doc_id: 289973 cord_uid: 1mczuxsy Summary Background Tocilizumab, a monoclonal antibody directed against the interleukin-6 receptor, has been proposed to mitigate the cytokine storm syndrome associated with severe COVID-19. keywords: covid19; data; health; icu; mortality; patients; propensity; protein; study; support; tocilizumab; treatment cache: cord-289973-1mczuxsy.txt plain text: cord-289973-1mczuxsy.txt item: #245 of 440 id: cord-290140-mmbzxz06 author: Lord, Heidi title: Effective communication is key to ICU nurses willingness to provide nursing care amidst the COVID-19 pandemic date: 2020-10-01 words: 2984 flesch: 45 summary: This study explores the willingness of ICU nurses to provide nursing care during the COVID-19 pandemic with the purpose of identifying the response of nursing staff to the pandemic and implementing support services to assist current and future pandemic response. Interestingly, the willingness of ICU nurses in our study to provide nursing care during the COVID-19 pandemic had no association with demographic factors. keywords: care; covid-19; icu; nurses; pandemic; study cache: cord-290140-mmbzxz06.txt plain text: cord-290140-mmbzxz06.txt item: #246 of 440 id: cord-290326-umv0q4d7 author: Stachowska, Ewa title: Nutritional Support in Coronavirus 2019 Disease date: 2020-06-12 words: 5121 flesch: 32 summary: A meta-analysis conducted in ICU patients demonstrated that early enteral nutrition within 24 h of ICU admission reduced mortality compared with delayed enteral intake (odds ratio, 0.45; 95% CI, 0.21-0.95, p = 0.038) The data on nutritional support in COVID-19 patients is still elusive. keywords: body; care; coronavirus; covid-19; energy; icu; infection; nutrition; patients; protein; risk; therapy cache: cord-290326-umv0q4d7.txt plain text: cord-290326-umv0q4d7.txt item: #247 of 440 id: cord-290460-d5e6y2r8 author: Knighton, Andrew J. title: Multi-factorial barriers and facilitators to high adherence to lung-protective ventilation using a computerized protocol: a mixed methods study date: 2020-07-28 words: 6503 flesch: 38 summary: Impact of the initial approach to LPV CDS tool implementation (Table 6) Strategies implemented during the initial rollout led to a meaningful increase in adherence rates for both LPV and the LPV CDS tool but were not sufficient alone to achieve high adherence. We analyzed 47 key informant interviews of ICU physicians, respiratory therapists (RTs), and nurses in 3 of the ICUs using a qualitative content analysis paradigm to investigate site variation as defined by adherence level (low, medium, high) and to identify barriers and facilitators to LPV and LPV CDS tool use. keywords: adherence; ards; barriers; cds tool; implementation; lpv; lpv cds; patients; site; study; tool; use; ventilation cache: cord-290460-d5e6y2r8.txt plain text: cord-290460-d5e6y2r8.txt item: #248 of 440 id: cord-290658-r2bqqovo author: Qian, Hao title: Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: a Retrospective in-ICU Study date: 2020-10-16 words: 3559 flesch: 38 summary: Consistently, the in-ICU cumulative survival curve of myocardial injury patients was significantly lower than that of non-myocardial injury patients (HR, 2.200; 95% CI 1.29 to 3.74; P=0.004) ( Figure 2b ). The only significant difference in therapy was that more non-myocardial injury patients received anticoagulation therapy than myocardial injury patients (69.4% vs. 39.0%, P<0.01) ( Table 2) . keywords: admission; covid-19; icu; injury; mortality; patients; study cache: cord-290658-r2bqqovo.txt plain text: cord-290658-r2bqqovo.txt item: #249 of 440 id: cord-291421-mrm9paiq author: Meijer, Eelco F. J. title: Azole-Resistant COVID-19-Associated Pulmonary Aspergillosis in an Immunocompetent Host: A Case Report date: 2020-06-06 words: 3117 flesch: 37 summary: Recent insights and challenges for patient management Concomitant occurrence of itraconazole-resistant and -susceptible strains of Aspergillus fumigatus in routine cultures High-frequency direct detection of triazole resistance in Aspergillus fumigatus from patients with chronic pulmonary fungal diseases in India Paradoxal trends in azole-resistant Aspergillus fumigatus in a national multicenter surveillance program Diagnosing invasive pulmonary aspergillosis in ICU patients: Putting the puzzle together Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically ill patients American Association for Bronchology and Interventional Pulmonology (AABIP) statement on the use of bronchoscopy and respiratory specimen collection in patients with suspected or confirmed COVID-19 infection Galactomannan in bronchoalveolar lavage fluid: A tool for diagnosing aspergillosis in intensive care unit patients Failure to detect circulating Aspergillus markers in a patient with chronic granulomatous disease and invasive aspergillosis A prospective study of fungal biomarkers to improve management of invasive fungal diseases in a mixed specialty critical care unit A prospective comparison of galactomannan in bronchoalveolar lavage fluid for the diagnosis of pulmonary invasive aspergillosis in medical patients under intensive care: Comparison with the diagnostic performance of galactomannan and of (1→3)-β-d-glucan chromogenic assay in serum samples Prospective study in critically ill non-neutropenic patients: Diagnostic potential of (1,3)-β-D-glucan assay and circulating galactomannan for the diagnosis of invasive fungal disease Detection of invasive pulmonary aspergillosis in critically ill patients by combined use of conventional culture, galactomannan, 1,3-β-D-glucan and Aspergillus specific nested polymerase chain reaction in a prospective pilot study Beta-D-glucan detection as a diagnostic test for invasive aspergillosis in immunocompromised critically ill patients with symptoms of respiratory infection: An autopsy-based study Comparison of 1,3-β-d-glucan with galactomannan in serum and bronchoalveolar fluid for the detection of Aspergillus species in immunosuppressed mechanical ventilated critically ill patients Diagnosis of invasive aspergillosis in intensive care unit patients Aspergillus-specific lateral-flow device and real-time PCR testing of bronchoalveolar lavage fluid: A combination biomarker approach for clinical diagnosis of invasive pulmonary aspergillosis Performance of galactomannan, 1,3-β-d-glucan, Aspergillus lateral-flow device, conventional culture, and PCR tests with bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis Point-of-care diagnosis of invasive aspergillosis in non-neutropenic patients: Aspergillus galactomannan lateral flow assay versus Aspergillus-specific lateral flow device test in bronchoalveolar lavage Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license We thank Paul E Verweij M.D. for helpful discussions. The numbers resemble what has been observed in influenza, where influenza in ICU patients has been identified as an independent risk factor for invasive pulmonary aspergillosis and which is associated with an even higher mortality rate than IPA alone [8] . keywords: aspergillosis; aspergillus; azole; cultures; fumigatus; icu; patients cache: cord-291421-mrm9paiq.txt plain text: cord-291421-mrm9paiq.txt item: #250 of 440 id: cord-291434-oktu3ieq author: Krishna, Lalit Kumar Radha title: The role of palliative medicine in ICU bed allocation in COVID-19: a joint position statement of the Singapore Hospice Council and the Chapter of Palliative Medicine Physicians date: 2020-06-01 words: 1542 flesch: 40 summary: Concurrently there should be flexibility in the deployment of manpower to Internal Medicine and ICU care to ensure resources are easily redistributed and portable across care settings. This will empower primary care teams to act swiftly and safely in delivering generalist palliative care in a manner that is consistent with the patient's values, beliefs and wishes. keywords: care; icu; patients; support cache: cord-291434-oktu3ieq.txt plain text: cord-291434-oktu3ieq.txt item: #251 of 440 id: cord-291481-ov1gkgpc author: Bonizzoli, Manuela title: Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date: 2016-05-02 words: 5002 flesch: 40 summary: An independent risk factor for ICU patients with ARDS is an impaired immunophenotype. It has been suggested that the presence of HSV1 in the respiratory samples of ICU patients correlates with the duration of tracheal intubation keywords: ards; dna; herpesviruses; icu; infection; influenza; patients; samples; tract cache: cord-291481-ov1gkgpc.txt plain text: cord-291481-ov1gkgpc.txt item: #252 of 440 id: cord-291742-donflx7w author: Khan, Raymond M. title: Implementing the comprehensive unit-based safety program model to improve the management of mechanically ventilated patients in Saudi Arabia date: 2018-09-05 words: 4443 flesch: 38 summary: The impact of a ventilator bundle on preventing ventilator-associated pneumonia: a multicenter study Guidelines for severe infections: are they useful? Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care The preventability of ventilator-associated events. We needed to implement other strategies to optimize patient care to improve outcomes. keywords: care; days; icu; patients; rates; safety; sedation; vap; ventilator cache: cord-291742-donflx7w.txt plain text: cord-291742-donflx7w.txt item: #253 of 440 id: cord-291886-phl8kh3f author: Anthi, Anastasia title: A Severe COVID-19 Case Complicated by Right Atrium Thrombus date: 2020-09-23 words: 1988 flesch: 31 summary: In addition, the low number of associated deep venous thromboses in COVID-19 patients may suggest the presence of pulmonary thrombosis rather than embolism Circulation Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Pulmonary embolism in COVID-19 patients: Awareness of an increased prevalence Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospi Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Routine venous thromboembolism prophylaxis may be inadequate in the hypercoagulable state of severe coronavirus disease 2019 COVID-19 and thrombotic complications: Pulmonary thrombosis rather than embolism? Thrombosis and COVID-19 pneumonia: keywords: anticoagulation; covid-19; icu; patient; thrombus cache: cord-291886-phl8kh3f.txt plain text: cord-291886-phl8kh3f.txt item: #254 of 440 id: cord-291955-mlju5f9u author: Haas, Lenneke E. M. title: Should we deny ICU admission to the elderly? Ethical considerations in times of COVID-19 date: 2020-06-09 words: 1209 flesch: 54 summary: The carefully balancing of pros and cons of ICU treatment should be done before ICU admission (as Advance Care Planning) but also during a (prolonged) ICU admission. As a consequence, a scenario can arise in which not every patient who needs ICU treatment can be admitted, and difficult decisions about allocation of ICU beds need to be made [2] [3] [4] . keywords: age; icu; patients cache: cord-291955-mlju5f9u.txt plain text: cord-291955-mlju5f9u.txt item: #255 of 440 id: cord-292094-vmsdhccp author: Mandell, Lionel A. title: Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults date: 2007-03-01 words: 28417 flesch: 34 summary: A statewide initiative to improve the care of hospitalized pneumonia patients: The Connecticut Pneumonia Pathway Project Implementation of an evidencebased guideline to reduce duration of intravenous antibiotic therapy and length of stay for patients hospitalized with community-acquired pneumonia: a randomized controlled trial Improving the quality of care for patients with pneumonia in very small hospitals Early mobilization of patients hospitalized with community-acquired pneumonia A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. For other patients with CAP, the recommendations for diagnostic testing focus on patients in whom the diagnostic yield is thought to be greatest. keywords: admission; adults; antibiotic; cap; care; community; criteria; culture; disease; evidence; factors; guidelines; hospital; icu; infection; influenza; level; management; mortality; pathogens; patients; pneumococcal; pneumonia; recommendation; resistance; respiratory; results; risk; sputum; studies; study; therapy; treatment; use cache: cord-292094-vmsdhccp.txt plain text: cord-292094-vmsdhccp.txt item: #256 of 440 id: cord-292273-xu9pb9ul author: Guillamet, C. V. title: TOWARD A COVID-19 SCORE-RISK ASSESSMENTS AND REGISTRY date: 2020-04-20 words: 3742 flesch: 47 summary: A voluntary registry option reporting subsequent patient outcomes will enable us to further validate and make improvements in the score and our understanding of COVID-19. US and European colleagues treating COVID-19 patients confirm that many deaths are from primary respiratory, not multiple system, failure 10 . keywords: covid-19; hospital; hours; license; mortality; patients; preprint; tacs cache: cord-292273-xu9pb9ul.txt plain text: cord-292273-xu9pb9ul.txt item: #257 of 440 id: cord-292474-dmgd99d6 author: Berardi, Giammauro title: Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center date: 2020-06-04 words: 4612 flesch: 38 summary: As a further issue, it has already been shown that cancer patients are more susceptible to COVID-19 infections: 1% of COVID-19 patients in China had a history of cancer as compared to 0.29% among normal Chinese population [2] . Italy was one of the first western countries diagnosing COVID-19 patients in late January and was certainly the one suffering the most by the sudden outbreak of the disease. keywords: cancer; cases; covid-19; icu; outbreak; pandemic; patients; surgery; transplantations cache: cord-292474-dmgd99d6.txt plain text: cord-292474-dmgd99d6.txt item: #258 of 440 id: cord-292490-djp9onk5 author: Verma, V. R. title: Projecting Demand-Supply Gap of Hospital Capacity in India in the face of COVID-19 pandemic using Age-Structured Deterministic SEIR model date: 2020-05-19 words: 5734 flesch: 41 summary: Further, we computed the daily turnover of each of these resources which was then adjusted for proportion of cases requiring mild, severe and critical care to arrive at maximum number of COVID-19 cases manageable by health care system of India. National Health Profile Directorate General of Health Services M of H and FW Estimating the maximum capacity of COVID-19 cases manageable per day given a health care system's constrained resources UTILIZATION PATTERN AND FINANCING OF PUBLIC HOSPITALS: keywords: beds; capacity; cases; covid-19; demand; health; india; lockdown; preprint; testing cache: cord-292490-djp9onk5.txt plain text: cord-292490-djp9onk5.txt item: #259 of 440 id: cord-292856-7hjzzxtm author: Viasus, Diego title: Influenza A(H1N1)pdm09-related pneumonia and other complications date: 2012-10-31 words: 4223 flesch: 27 summary: 8, 24 One study 27 found that 70% of patients with influenza A(H1N1)pdm09 virus infection and invasive group A Streptococcus died, compared with an overall mortality rate of 2-6% for hospitalized influenza A(H1N1)pdm09 patients in other studies. Community-acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus Pulmonary imaging of pandemic influenza H1N1 infection: relationship between clinical presentation and disease burden on chest radiography and CT During the herald wave of the pandemic bacterial pneumonia relatively rare with fatal swine influenza (H1N1) pneumonia: if chest films have no focal segmental/lobar infiltrates, antibiotic therapy is unnecessary A 1-year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of COPD Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Children with asthma hospitalized with seasonal or pandemic influenza Clinical findings and demographic factors associated with intensive care unit admission in Utah due to 2009 novel influenza A (H1N1) infection Hospitalizations for pandemic (H1N1) 2009 among Maori and Pacific Islanders Surveillance of the first 205 confirmed hospitalised cases of pandemic H1N1 influenza in Ireland Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy Clinical presentation and prognosis of the 2009 H1N1 influenza A infection in HIV-1-infected patients: a Spanish multicenter study Early use of glucocorticoids was a risk factor for critical disease and death from pH1N1 infection Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis Risk factors for hospitalization and severe outcomes of 2009 pandemic H1N1 influenza in Quebec Timing of oseltamivir administration and outcomes in hospitalized adults with pandemic 2009 influenza A(H1N1) virus infection The role of pneumonia scores in the emergency room in patients infected by 2009 H1N1 infection Severity assessment tools in ICU patients with 2009 Influenza A (H1N1) pneumonia Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review Acute myocarditis mimicking acute myocardial infarction associated with pandemic 2009 (H1N1) influenza A virus Cardiac manifestations in patients with pandemic (H1N1) 2009 virus infection needing intensive care Electrocardiographic abnormalities in patients with novel H1N1 influenza virus infection Pediatric neurological complications of 2009 pandemic influenza A (H1N1) keywords: a(h1n1)pdm09; admission; bacterial; chronic; complications; disease; infection; influenza; pandemic; patients; pneumonia; virus cache: cord-292856-7hjzzxtm.txt plain text: cord-292856-7hjzzxtm.txt item: #260 of 440 id: cord-293093-cq43592t author: Ismaeil, Taha title: Survival of mechanically ventilated patients admitted to intensive care units: Results from a tertiary care center between 2016-2018 date: 2019-08-17 words: 3692 flesch: 33 summary: They found that the survival of ICU patients depends on factors that develop during the course of the ventilation in addition to those factors that cause the initiation of mechanical ventilation. For the meanwhile, efforts should be carefully planned when mechanical ventilation is needed among ICU patients. keywords: icu; mortality; patients; rate; study; survival; ventilation cache: cord-293093-cq43592t.txt plain text: cord-293093-cq43592t.txt item: #261 of 440 id: cord-293552-k3wvvnmd author: Yifan, Tang title: Symptom Cluster of ICU nurses treating COVID-19 pneumonia patients in Wuhan, China date: 2020-04-08 words: 952 flesch: 39 summary: key: cord-293552-k3wvvnmd authors: Yifan, Tang; Ying, Liu; Chunhong, Gao; Jing, Song; Rong, Wang; Zhenyu, Li; Zejuan, Gu; Peihung, Liao title: Symptom Cluster of ICU nurses treating COVID-19 pneumonia patients in Wuhan, China date: 2020-04-08 journal: J Pain Symptom Manage DOI: 10.1016/j.jpainsymman.2020.03.039 sha: doc_id: 293552 cord_uid: k3wvvnmd Abstract Objective In treating highly infectious COVID-19 pneumonia, ICU nurses face a high risk of developing somatic symptom disorder (SSD). The present study aims to investigate the symptoms and causes of SSD of ICU nurses treating COVID-19 pneumonia. keywords: cluster; icu; nurses; symptom cache: cord-293552-k3wvvnmd.txt plain text: cord-293552-k3wvvnmd.txt item: #262 of 440 id: cord-294270-do6i6ymq author: Banu, Buyukaydin title: Pneumonia date: 2019-11-29 words: 7323 flesch: 32 summary: The mechanisms that increase the incidence and mortality rates in elderly pneumonia patients are not fully understood. Mortality in elderly patients may be 25% higher than in the general population (10%). keywords: age; cap; cases; community; infection; mortality; pathogens; patients; pneumonia; risk; therapy; treatment; years cache: cord-294270-do6i6ymq.txt plain text: cord-294270-do6i6ymq.txt item: #263 of 440 id: cord-294591-793ywpcd author: Hu, Xiaoyun title: Self-Reported Use of Personal Protective Equipment among Chinese Critical Care Clinicians during 2009 H1N1 Influenza Pandemic date: 2012-09-05 words: 3621 flesch: 35 summary: Vaccination status, positive attitudes towards PPE use, cultural factor (perceived reprimand for noncompliance), and organizational factors (availability of PPE in ICU, notice of influenza precautions) were identified as independent predictors of high compliance, while negative attitudes towards PPE use and violation of recommended PPE use were associated with low compliance. Similar to the study of Daugherty and coworkers [16] , we found a similar proportion (74%) of respondents claiming their confidence to improve compliance to PPE use, again suggesting perception of inadequate PPE use among most respondents. keywords: care; compliance; influenza; knowledge; pandemic; ppe; use cache: cord-294591-793ywpcd.txt plain text: cord-294591-793ywpcd.txt item: #264 of 440 id: cord-294992-p50jdpt7 author: Levy, Yael title: Unexpected benefits of the COVID challenge: When critically ill adult patients are managed in a pediatric PACU date: 2020-09-22 words: 725 flesch: 41 summary: key: cord-294992-p50jdpt7 authors: Levy, Yael; Bonnet, Marie‐Pierre; Chemam, Sarah; Sabourdin, Nada; Louvet, Nicolas; Constant, Isabelle title: Unexpected benefits of the COVID challenge: When critically ill adult patients are managed in a pediatric PACU date: 2020-09-22 journal: Paediatr Anaesth DOI: 10.1111/pan.13980 sha: doc_id: 294992 cord_uid: p50jdpt7 nan and gynecology department: we have no on-site adult ICU, cardiology, pneumology, and infectiology. The challenge of congenital heart disease worldwide: Epidemiologic and demographic facts Heart Care International website Children's HeartLink website Haiti Cardiac Alliance website HeartGift Foundation website Unexpected benefits of the COVID challenge: When critically ill adult patients are managed in a pediatric PACU | 959 Union/European Economic Area and the United Kingdom French pandemic resistance The authors report no conflict of interest. keywords: adult; icu; patients cache: cord-294992-p50jdpt7.txt plain text: cord-294992-p50jdpt7.txt item: #265 of 440 id: cord-295287-j3gm9vpz author: Michard, Frédéric title: Haemodynamic Monitoring and Management in COVID-19 Intensive Care Patients: An International Survey date: 2020-08-09 words: 2874 flesch: 39 summary: According to respondents, a majority of COVID-19 ICU patients frequently or very frequently received continuous vasopressor support (56%) and had an echocardiography performed (54%). Our survey confirms that vasopressor support is not uncommon in COVID-19 ICU patients and suggests that different cardiac function phenotypes may be observed. keywords: covid-19; fluid; patients; respondents; responsiveness cache: cord-295287-j3gm9vpz.txt plain text: cord-295287-j3gm9vpz.txt item: #266 of 440 id: cord-295329-y7rx3ky4 author: Mattioli, Francesco title: Tracheostomy in the COVID-19 pandemic date: 2020-04-22 words: 1382 flesch: 46 summary: In the LUNG SAFE study, involving ARDS patients from 459 ICUs across 50 countries, tracheostomy was performed in 13% of patients, whose 75% after the first week of ICU stay [6] . No recommendation can be given about tracheostomy within 7 days in COVID-19 patients. keywords: covid-19; icu; patients; tracheostomy cache: cord-295329-y7rx3ky4.txt plain text: cord-295329-y7rx3ky4.txt item: #267 of 440 id: cord-295332-wlnss6bg author: AL Shareef, Khaled title: Cytokine Blood Filtration Responses in COVID-19 date: 2020-05-28 words: 2684 flesch: 44 summary: medRxiv Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19) Regulation of interferon production as a potential strategy for CO-VID-19 treatment Clinical trials on drug repositioning for CO-VID-19 treatment The epidemiology and pathogenesis of coronavirus disease (CO-VID-19) outbreak Multiscale biofluidic and nanobiotechnology approaches for treating sepsis in extracorporeal circuits Cytokine removal with high cut-off membrane: review of literature Early report: the use of Cytosorb™ haemabsorption column as an adjunct in managing severe sepsis: initial experiences, review and recommendations What have we learned about the use of cytosorb adsorption columns? Cytokine reduction in the setting of an ARDS-associated inflammatory response with multiple organ failure Severe myoglobinuric acute kidney injury in a kidney recipient: rapid recovery after hemodialysis with the super high-flux membrane Theralite® Organ dysfunction during continuous veno-venous high cut-off hemodialysis in patients with septic acute kidney injury: a prospective observational study Application of endotoxin and cytokine adsorption haemofilter in septic acute kidney injury due to Gram-negative bacterial infection Continuous renal replacement therapy with the adsorbing filter oXiris in septic patients: a case series Bodelsson M. Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock: a randomized crossover double-blind study Septic shock due to infected giant venous malformation complicated by massive bleeding Continuous renal replacement therapy with a polymethyl methacrylate membrane hemofilter suppresses inflammation in patients after open-heart surgery with cardiopulmonary bypass Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model. The oXiris membrane has been investigated in septic shock patients for cytokine reduction. keywords: covid-19; cytokine; group; membrane; patients; treatment cache: cord-295332-wlnss6bg.txt plain text: cord-295332-wlnss6bg.txt item: #268 of 440 id: cord-295712-35i0mhz4 author: Fox, Gregory J title: Modelling the impact of COVID‐19 on intensive care services in New South Wales date: 2020-05-08 words: 783 flesch: 39 summary: We conducted a partial rank correlation coefficient study of nine key model parameters; Reproduction number, probability of hospitalisation, duration of hospitalisation, probability of being admitted to ICU given hospitalisation, duration of ICU admission, time in E 1 , time in E 2 , time in I 1 , time in I 2 against four key outcomes; peak hospitalisation numbers, peak ICU numbers, time to peak hospitalisation and time to peak ICU as shown in Figure 3 . The modelled outcome was hospitalised cases, and ICU cases, per 100,000 population. keywords: icu; model; peak cache: cord-295712-35i0mhz4.txt plain text: cord-295712-35i0mhz4.txt item: #269 of 440 id: cord-296435-6dergkha author: Wang, Tiehua title: Thrombocytopenia Is Associated with Acute Respiratory Distress Syndrome Mortality: An International Study date: 2014-04-14 words: 4479 flesch: 34 summary: Although not significant, ARDS patients were in the ICU longer (ARDS median = 13 days; non-ARDS median = 9 days; p = 0.21) and on mechanical ventilation longer (ARDS median = 7 days; non-ARDS median = 5 days;p = 0.53) than non-ARDS patients. In contrast, pneumonia (p = 0.002) and external pulmonary injury (p = 0.013) had higher mortality rates in non-ARDS patients. keywords: ards; beijing; boston; cohort; icu; mortality; patients; risk; thrombocytopenia cache: cord-296435-6dergkha.txt plain text: cord-296435-6dergkha.txt item: #270 of 440 id: cord-296511-y2vhh6oq author: Zhang, YiMin title: Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit date: 2016-01-06 words: 3853 flesch: 48 summary: Here, we report a 1.8% (2/112) incidence of HH in the largest single-centre cohort of ICU patients with A(H7N9) infection. The incidence of HH in A(H7N9) patients is similar to that in ICU patients with other aetiologies. keywords: a(h7n9; admission; failure; hepatitis; infection; liver; patients cache: cord-296511-y2vhh6oq.txt plain text: cord-296511-y2vhh6oq.txt item: #271 of 440 id: cord-297062-dmiplvt2 author: Almekhlafi, Ghaleb A. title: Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients date: 2016-05-07 words: 4410 flesch: 45 summary: Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Acute management and long-term survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS APACHE II: a severity of disease classification system The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Interestingly, Acinetobacter baumannii, which is an emerging fatal infection in ICU patients worldwide, was isolated from deep tracheal aspirates in one in four patients. keywords: admission; coronavirus; cov; east; icu; infection; mers; middle; patients; syndrome cache: cord-297062-dmiplvt2.txt plain text: cord-297062-dmiplvt2.txt item: #272 of 440 id: cord-297327-19dfgfz6 author: Drożdżal, Sylwester title: COVID-19: Pain Management in Patients with SARS-CoV-2 Infection—Molecular Mechanisms, Challenges, and Perspectives date: 2020-07-20 words: 5681 flesch: 37 summary: This narrative review summarizes current knowledge regarding challenges associated with pain assessment and management in COVID-19 patients. It is believed that myalgia in COVID-19 patients might reflect the generalized inflammation and cytokine response [34] . keywords: coronavirus; cov-2; covid-19; disease; effects; infection; management; opioids; pain; patients; sars; symptoms; treatment; use cache: cord-297327-19dfgfz6.txt plain text: cord-297327-19dfgfz6.txt item: #273 of 440 id: cord-297544-h5dsnex9 author: Kulkarni, Sagar title: The bone prone team date: 2020-06-26 words: 690 flesch: 69 summary: Once we (the ICU and orthopaedic teams) had all donned our PPE, we entered the unit together. A lone, lumbering orthopaedic consultant arrived, his eyebrows slightly furrowed, unsure of what was about to happen. keywords: orthopaedic; proning cache: cord-297544-h5dsnex9.txt plain text: cord-297544-h5dsnex9.txt item: #274 of 440 id: cord-297682-knd6avhu author: Mulpuru, Sunita title: Hospital Resource Utilization and Patient Outcomes Associated with Respiratory Viral Testing in Hospitalized Patients date: 2015-08-17 words: 3397 flesch: 34 summary: To date, whether respiratory viral testing in patients improves outcomes or care processes has not been proven in large studies. Our study also did not find that respiratory viral testing was associated with significant reductions in antibiotic use, chest imaging studies, bronchoscopy, or microbiologic cultures among patients with infectious respiratory symptoms. keywords: hospital; isolation; patients; sample; study; swab cache: cord-297682-knd6avhu.txt plain text: cord-297682-knd6avhu.txt item: #275 of 440 id: cord-299104-kb5gsig5 author: Riou, Marianne title: Clinical characteristics of and outcomes for patients with COVID-19 and comorbid lung diseases primarily hospitalized in a conventional pulmonology unit: a retrospective study date: 2020-11-12 words: 3627 flesch: 41 summary: A Nationwide Analysis Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 -COVID-NET, 14 States Detection of asthma and chronic obstructive pulmonary disease in primary care Changes in medication adherence among patients with asthma and COPD during the Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2 ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19 Autoimmune Responses in Severe Asthma Therapeutic potential of ciclesonide inahalation for COVID-19 pneumonia: However, a tendency to higher global mortality was observed in COVID-19 patients with CLD. keywords: asthma; cld; copd; covid-19; disease; icu; lung; patients; risk cache: cord-299104-kb5gsig5.txt plain text: cord-299104-kb5gsig5.txt item: #276 of 440 id: cord-299254-kqpnwkg5 author: Sun, Yingcheng title: INSMA: An integrated system for multimodal data acquisition and analysis in the intensive care unit date: 2020-04-28 words: 4610 flesch: 36 summary: The prototype system has been tested using ICU patient data from ECG to understand how variability in the heartbeat time-series can be used to dynamically track patient state [19] . All three modules are developed using MFC and C/C++, so that they all run in the same operating environment and use compatible data formats, and therefore provide a complete solution for data acquisition, parsing and visualization. keywords: acquisition; analysis; care; data; icu; information; insma; monitor; patient; system; time; visualization cache: cord-299254-kqpnwkg5.txt plain text: cord-299254-kqpnwkg5.txt item: #277 of 440 id: cord-299650-lhphdjeu author: Whittle, John title: Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19 date: 2020-09-28 words: 1159 flesch: 38 summary: Further, understanding the energy expenditure of COVID-19 ICU patients is essential to help determine safe, optimal nutrition needs for the ICU provider [3] , as both over-/underfeeding is associated with increased ICU mortality Longitudinal IC data presented here demonstrate a progressive hypermetabolic phenotype beginning 1 week post-intubation in COVID-19 ICU patients, with significantly greater mREE versus predictive equations or ASPEN-recommended 11-14 kcal/kg ABW for obese subjects used currently to determine energy requirements. keywords: covid-19; data; icu; mree; patients cache: cord-299650-lhphdjeu.txt plain text: cord-299650-lhphdjeu.txt item: #278 of 440 id: cord-300176-lurzcliy author: van Mol, Margo M. C. title: Developing and testing a nurse-led intervention to support bereavement in relatives in the intensive care (BRIC study): a protocol of a pre-post intervention study date: 2020-08-18 words: 5646 flesch: 39 summary: Bereaved relatives may develop complicated grief as a consequence of this burdensome situation; however, little is known about appropriate options in quality care supporting bereaved relatives and the prevalence and predictors of complicated grief in bereaved relatives of deceased ICU patients in the Netherlands. The aim of this study is to develop and implement a multicomponent bereavement support intervention for relatives of deceased ICU patients and to evaluate the effectiveness of this intervention on complicated grief, anxiety, depression and posttraumatic stress in bereaved relatives. keywords: bereavement; care; death; grief; icu; intervention; patients; quality; relatives; study; support cache: cord-300176-lurzcliy.txt plain text: cord-300176-lurzcliy.txt item: #279 of 440 id: cord-300230-a3jk6w90 author: Ding, Ji-Guang title: Retrospective analysis of nosocomial infections in the intensive care unit of a tertiary hospital in China during 2003 and 2007 date: 2009-07-25 words: 3806 flesch: 41 summary: System Report, data summary from Nosocomial infections in medical-surgical intensive care units in Argentina: attributable mortality and length of stay Prevalence rate of nosocomial infection in a general hospital Surveillance of risk factors for nosocomial infection in patients in intensive care units Study on the changing trends in national nosocomial infection transaction investigation results Nosocomial infections in medical intensive care units in the United States Nosocomial infections: prospective survey of incidence in five French intensive care units Nosocomial infections in a neurosurgery intensive care unit Device-associated nosocomial infections in 55 intensive care units of 8 developing countries Epidemiology, risk factors and outcome of nosocomial infections in a Respiratory Intensive Care Unit in North India The excess length of stay was then calculated by subtracting the average length of stay for patients without nosocomial infection from that of patients with nosocomial infections. keywords: care; icu; infections; patients; rate; study; tract cache: cord-300230-a3jk6w90.txt plain text: cord-300230-a3jk6w90.txt item: #280 of 440 id: cord-300356-oorac5he author: Nair, Girish B. title: Community-Acquired Pneumonia: An Unfinished Battle date: 2011-10-05 words: 7388 flesch: 35 summary: Eur Respir Severe community-acquired pneumonia: validation of the Infectious Diseases Society of America/American Thoracic Society guidelines to predict an intensive care unit admission Validation of the Infectious Disease Society of America/American Thoracic Society 2007 guidelines for severe community-acquired pneumonia PIRO score for community-acquired pneumonia: a new prediction rule for assessment of severity in intensive care unit patients with community-acquired pneumonia SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia Quality of care, process, and outcomes in elderly patients with pneumonia Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia Comparison of levofloxacin and cefotaxime combined with ofloxacin for ICU patients with community-acquired pneumonia who do not require vasopressors Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock Early switch from intravenous to oral antibiotics in hospitalized patients with bacteremic community-acquired Streptococcus pneumoniae pneumonia Predicting bacteremia in patients with community-acquired pneumonia Rapid diagnosis of bacteremic pneumococcal infections in adults by using the Binax NOW Streptococcus pneumoniae urinary antigen test: a prospective, controlled clinical evaluation Utility of a pneumonia severity index in the optimization of the diagnostic and therapeutic effort for community-acquired pneumonia Trends in legionnaire's disease, 1980-1998: declining mortality and new patterns of diagnosis Current and potential usefulness of pneumococcal urinary antigen detection in hospitalized patients with community-acquired pneumonia to guide antimicrobial therapy Cardiovascular and inflammatory biomarkers to predict short-and long-term survival in community-acquired pneumonia: results from the German Competence Network, CAPNETZ Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia Procalcitonin-Guided Antibiotic Therapy and Hospitalisation in Patients with Lower Respiratory Tract Infections (ProHOSP) Study Group. keywords: antibiotic; cap; community; disease; factors; icu; illness; infection; mortality; patients; pneumonia; respiratory; risk; therapy cache: cord-300356-oorac5he.txt plain text: cord-300356-oorac5he.txt item: #281 of 440 id: cord-300892-zzl0c9nj author: Sukhonthamarn, Kamolsak title: Response to Letter to the Editor titled ‘Risk Modeling for Unplanned Intensive Care Unit (ICU) Admission’ date: 2020-05-08 words: 438 flesch: 37 summary: key: cord-300892-zzl0c9nj authors: Sukhonthamarn, Kamolsak; Grosso, Matthew J.; Parvizi, Javad title: Response to Letter to the Editor titled ‘Risk Modeling for Unplanned Intensive Care Unit (ICU) Admission’ date: 2020-05-08 journal: J Arthroplasty DOI: 10.1016/j.arth.2020.05.005 sha: doc_id: 300892 cord_uid: zzl0c9nj nan To the Editor in reply, We are grateful to the letter authors for their interest in our study regarding risk factors for unplanned intensive care unit (ICU) admission after elective total joint arthroplasty, which was recently published in the Journal of Arthroplasty [1] . Risk Factors for Unplanned Admission to the Intensive Care Unit After Elective Total Joint Arthroplasty COVID-19: Recommendations for Management of Elective Surgical Procedures American College of Surgeons Unplanned Admission to the Intensive Care Unit After Total Hip Arthroplasty Prospective Study of Unplanned Admission to the Intensive Care Unit after Total Hip Arthroplasty Which patients need critical care intervention after total joint arthroplasty? keywords: arthroplasty cache: cord-300892-zzl0c9nj.txt plain text: cord-300892-zzl0c9nj.txt item: #282 of 440 id: cord-300897-lih5f6cj author: Du, Bin title: Clinical review: Critical care medicine in mainland China date: 2010-02-25 words: 2765 flesch: 45 summary: key: cord-300897-lih5f6cj authors: Du, Bin; Xi, Xiuming; Chen, Dechang; Peng, Jinmin title: Clinical review: Critical care medicine in mainland China date: 2010-02-25 journal: Crit Care DOI: 10.1186/cc8222 sha: doc_id: 300897 cord_uid: lih5f6cj Critical care medicine began in mainland China in the early 1980s. Although advanced life support techniques, especially positive pressure ventilation, inspired the development of critical care medicine in Europe and North America in the 1950s, critical care medicine is still one of the newest disciplines of clinical medicine in mainland China. keywords: care; china; critical; icu; mainland; medicine cache: cord-300897-lih5f6cj.txt plain text: cord-300897-lih5f6cj.txt item: #283 of 440 id: cord-301011-xbuqd0j5 author: Felten-Barentsz, Karin M title: Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19 date: 2020-06-18 words: 3953 flesch: 32 summary: Therefore, we recommend to not detach the ventilation system for the purpose of respiratory function testing, respiratory muscle training, or breathing exercises. The team may decide that benefits of respiratory muscle training outweigh the safety risks. keywords: covid-19; hospital; mobilization; muscle; patients; recommendations; support; therapists; training cache: cord-301011-xbuqd0j5.txt plain text: cord-301011-xbuqd0j5.txt item: #284 of 440 id: cord-301336-rycbeax7 author: Cao, Jianlei title: Clinical features and short-term outcomes of 18 patients with corona virus disease 2019 in intensive care unit date: 2020-03-02 words: 838 flesch: 51 summary: ICU patients had a higher mortality rate than non-ICU patients (33.3% vs. 13.1%), but this difference was not significant (P = 0.081). The timeline of SARS-CoV-2 onset in ICU patients is shown in Fig. keywords: icu; patients cache: cord-301336-rycbeax7.txt plain text: cord-301336-rycbeax7.txt item: #285 of 440 id: cord-302177-8w3ojgd4 author: Cavayas, Yiorgos Alexandros title: Early experience with critically ill patients with COVID-19 in Montreal date: 2020-09-15 words: 4084 flesch: 53 summary: A significant proportion of ICU patients likely acquired the virus in healthcare facilities, highlighting the importance of appropriate infection control policies. 11, 12 Intensive care unit admission criteria for COVID-19 patients included an oxygen requirement of [ 5 LÁmin -1 accompanied with signs of respiratory distress. keywords: care; cases; covid-19; hospital; icu; imv; mortality; outcomes; patients; ventilation cache: cord-302177-8w3ojgd4.txt plain text: cord-302177-8w3ojgd4.txt item: #286 of 440 id: cord-302393-hrz3bypr author: Omrani, Ali S. title: The first consecutive 5000 patients with Coronavirus Disease 2019 from Qatar; a nation-wide cohort study date: 2020-10-19 words: 4544 flesch: 48 summary: COVID-19 patients with significant co-morbidities or moderate to severe disease were hospitalized for inpatient management. This has stimulated discussions around rationing of critical care support for COVID-19 patients, including potentially difficult decisions to withdraw resources from one patient to provide them to another keywords: admission; age; cov-2; covid-19; disease; icu; patients; sars; study; years cache: cord-302393-hrz3bypr.txt plain text: cord-302393-hrz3bypr.txt item: #287 of 440 id: cord-302571-vb9ks4mq author: Damiani, Giovanni title: Biologics increase the risk of SARS‐CoV‐2 infection and hospitalization, but not ICU admission and death: Real‐life data from a large cohort during red‐zone declaration date: 2020-05-19 words: 738 flesch: 40 summary: Thus, we performed this study aiming to understand the effect of biologics in PsO patients during COVID-19 outbreak focusing on symptomatic patients quarantined at home, hospitalized, and their prognosis. PsO patients on biologics should be carefully monitored with telemedicine during COVID‐19 outbreak and early treated at home to limit hospital overwhelm. keywords: biologics; patients; pso cache: cord-302571-vb9ks4mq.txt plain text: cord-302571-vb9ks4mq.txt item: #288 of 440 id: cord-302997-39o08tt1 author: Ceruti, S. title: Reduced mortality and shorten ICU stay in SARS-COV-2 pneumonia: a low PEEP strategy date: 2020-05-08 words: 3557 flesch: 47 summary: Patients presenting partial respiratory failure combining peripheral saturation (SpO 2 ) lower than 85% and dyspnea (or mental confusion), or patients with dyspnea (or mental confusion) alone, were eligible to be admitted in ICU. During daily screening of the lower limb ultrasound, COVID-19 ICU patients showed a high prevalence rate of DVTs and PEs, even under preventive anticoagulation. keywords: covid-19; icu; license; medrxiv; patients; peep; preprint cache: cord-302997-39o08tt1.txt plain text: cord-302997-39o08tt1.txt item: #289 of 440 id: cord-303024-a1y01vdv author: Alshukry, A. title: Clinical characteristics of Coronavirus Disease 2019 (COVID-19) patients in Kuwait date: 2020-06-16 words: 4905 flesch: 47 summary: Comorbidities were more prevalent in ICU death group when compared to other groups (p<0.05) including Diabetes (40%), Hypertension (46.7%), Asthma (20.3%) and cardiovascular disease (21.7%). Blood biochemistry analysis showed that ICU death group had a characteristic abnormal pattern of certain markers upon admission in the ICU. keywords: cases; death; group; icu; license; medrxiv; medrxiv preprint; patients; preprint cache: cord-303024-a1y01vdv.txt plain text: cord-303024-a1y01vdv.txt item: #290 of 440 id: cord-303292-iheq50ub author: De Jong, Audrey title: How to ventilate obese patients in the ICU date: 2020-10-23 words: 7499 flesch: 36 summary: an official American thoracic society clinical practice guideline Perioperative care of the obese patient Respiratory management of the obese patient undergoing surgery Mechanical ventilation in obese ICU patients: from intubation to extubation Pathophysiology of sleep apnea Cardiac arrest and mortality related to intubation procedure in critically ill adult patients: a multicenter cohort study Difficult intubation in obese patients: incidence, risk factors, and complications in the operating theatre and in intensive care units Videolaryngoscope versus Macintosh laryngoscope for tracheal intubation in adults with obesity: a systematic review and meta-analysis A multicenter, randomized trial of ramped position vs sniffing position during endotracheal intubation of critically ill adults Positive end-expiratory pressure during induction of general anesthesia increases duration of nonhypoxic apnea in morbidly obese patients Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial Bag-mask ventilation during tracheal intubation of critically ill adults Focus on noninvasive respiratory support before and after mechanical ventilation in patients with acute respiratory failure Prevention of atelectasis in morbidly obese patients during general anesthesia and paralysis: a computerized tomography study Protective versus conventional ventilation for surgery: a systematic review and individual patient data meta-analysis Intraoperative ventilation settings and their associations with postoperative pulmonary complications in obese patients Noninvasive monitoring of lung recruitment maneuvers in morbidly obese patients: the role of pulse oximetry and volumetric capnography Positive endexpiratory pressure optimization using electric impedance tomography in morbidly obese patients during laparoscopic gastric bypass surgery Effect of intraoperative high positive end-expiratory pressure (PEEP) with recruitment maneuvers vs low peep on postoperative pulmonary complications in obese patients: a randomized clinical trial A trial of intraoperative lowtidal-volume ventilation in abdominal surgery Spontaneous breathing with airway pressure release ventilation favors ventilation in dependent lung regions and counters cyclic alveolar collapse in oleic-acid-induced lung injury: a randomized controlled computed tomography trial NAVa In Acute respira-TORy failure (NAVIATOR) key: cord-303292-iheq50ub authors: De Jong, Audrey; Wrigge, Hermann; Hedenstierna, Goran; Gattinoni, Luciano; Chiumello, Davide; Frat, Jean-Pierre; Ball, Lorenzo; Schetz, Miet; Pickkers, Peter; Jaber, Samir title: How to ventilate obese patients in the ICU date: 2020-10-23 journal: Intensive Care Med DOI: 10.1007/s00134-020-06286-x sha: doc_id: 303292 cord_uid: iheq50ub Obesity is an important risk factor for major complications, morbidity and mortality related to intubation procedures and ventilation in the intensive care unit (ICU). keywords: airway; ards; failure; icu; lung; niv; obese; obesity; patients; peep; pressure; ventilation cache: cord-303292-iheq50ub.txt plain text: cord-303292-iheq50ub.txt item: #291 of 440 id: cord-304061-nfpzcago author: Crispi, F. title: LOW BIRTH WEIGHT AS A RISK FACTOR FOR SEVERE COVID-19 IN ADULTS date: 2020-09-15 words: 3366 flesch: 51 summary: A total of 1,215 of them (67%) reported mild symptoms and did not require hospital admission whereas 607 (33%) were hospitalized of whom 46 (8%) patients required ICU admission (30 of them (65% of ICU patients) were mechanically ventilated, and one male patient (2% of ICU patients) died at the age 68 years as reported later by her daughter. Like we observed in the developing cohort, ICU patients in the validation dataset were older, more frequently males, had a higher BMI and a higher prevalence of hypertension. keywords: covid-19; license; medrxiv; perpetuity; preprint; september cache: cord-304061-nfpzcago.txt plain text: cord-304061-nfpzcago.txt item: #292 of 440 id: cord-304124-ym9mf5wz author: Li, Jia title: Meta-analysis investigating the relationship between clinical features, outcomes, and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia date: 2020-06-12 words: 2739 flesch: 43 summary: Compared with non-severe patients, those with severe illness or admission to the ICU were more likely to have one or more comorbidities (OR=3.07, 95% CI: 1.56-6.05, P<0.001, I 2 =79.0%), including chronic obstructive pulmonary disease (OR=5.08, 95% CI: 2.68-9.63, P<0.001, Figure 1A -1G) . Severely ill patients or those cared for in the ICU had a higher mortality rate and lower discharge rate than non-severe patients or patients without ICU admission. keywords: clinical; covid-19; disease; icu; patients; studies cache: cord-304124-ym9mf5wz.txt plain text: cord-304124-ym9mf5wz.txt item: #293 of 440 id: cord-304736-lkjsh3fu author: Taccone, Fabio Silvio title: Higher Intensity Thromboprophylaxis Regimens and Pulmonary Embolism in Critically Ill Coronavirus Disease 2019 Patients date: 2020-08-18 words: 2610 flesch: 41 summary: Furthermore, the high mortality reported for COVID-19 patients undergoing mechanical ventilation, when compared with contemporary ARDS cohorts, raised serious concerns on potential additional complications occurring during this disease that may further compromise lung function and recovery. In one study, more than 70% of COVID-19 patients had criteria for disseminated intravascular coagulation; also, higher D-dimer levels and prolonged prothrombin (PT) and activated partial thromboplastin (aPTT) times were observed in nonsurvivors when compared with survivors on hospital admission (3) . keywords: embolism; patients; study; thromboprophylaxis cache: cord-304736-lkjsh3fu.txt plain text: cord-304736-lkjsh3fu.txt item: #294 of 440 id: cord-304746-7yzybukk author: Li, Xinye title: Cardiac injury associated with severe disease or ICU admission and death in hospitalized patients with COVID-19: a meta-analysis and systematic review date: 2020-07-28 words: 4590 flesch: 42 summary: CONCLUSIONS: COVID-19 patients with elevated TnI levels are at significantly higher risk of severe disease, ICU admission, and death. [Image: see text] Conclusions: COVID-19 patients with elevated TnI levels are at significantly higher risk of severe disease, ICU admission, and death. keywords: cardiac; covid-19; disease; icu; icu admission; levels; non; patients cache: cord-304746-7yzybukk.txt plain text: cord-304746-7yzybukk.txt item: #295 of 440 id: cord-305068-9qh8vgtc author: Pinto Pereira, João title: Management of COVID-19 Coagulopathy in a Patient with Severe Haemophilia A date: 2020-09-25 words: 1557 flesch: 35 summary: key: cord-305068-9qh8vgtc authors: Pinto Pereira, João; Hantson, Philippe; Gerard, Ludovic; Wittebole, Xavier; Laterre, Pierre-François; Lambert, Catherine; Hermans, Cédric title: Management of COVID-19 Coagulopathy in a Patient with Severe Haemophilia A date: 2020-09-25 journal: Acta Haematol DOI: 10.1159/000510591 sha: doc_id: 305068 cord_uid: 9qh8vgtc A 54-year-old man with a long history of severe haemophilia A treated prophylactically with efmoroctocog alpha (3,000 IU twice weekly) was diagnosed with COVID-19 infection. The diagnosis of COVID-19 infection was rapidly obtained by reverse transcription-polymerase chain reaction (RT-PCR) on the nasopharyngeal swab, and lung computed tomography revealed bilateral ground glass opacities. keywords: covid-19; haemophilia; icu; infection; patients cache: cord-305068-9qh8vgtc.txt plain text: cord-305068-9qh8vgtc.txt item: #296 of 440 id: cord-305074-wz17u4e7 author: Fernandez, Javier title: Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection date: 2020-08-24 words: 2663 flesch: 40 summary: COVID-19: Consider cytokine storm syndromes and immunosuppression Chinese Clinical Trial Registry: A Multicenter, Randomized Controlled Trial for the Efficacy and Safety of Tocilizumab in the Treatment of New Coronavirus Pneumonia (COVID-19) Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: Reanalysis of a prior phase III trial The mechanisms of action of plasma exchange Role of plasma exchange, leukocytapheresis, and plasma diafiltration in management of refractory macrophage activation syndrome Use of therapeutic plasma exchange as a rescue therapy in 2009 pH1N1 influenza A-an associated respiratory failure and hemodynamic shock Dysregulation of immune response in patients with COVID-19 in Wuhan, China Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Human serum albumin, systemic inflammation, and cirrhosis Therapeutic plasma exchange removes endogenous and exogenous inducers of the systemic inflammatory response (pathogen-associated molecular pattern and damage-associated molecular pattern) and proinflammatory mediators (cytokines and reactive oxygen species) that are involved in the pathogenesis of organ failure (8) . keywords: days; exchange; failure; icu; patients; plasma cache: cord-305074-wz17u4e7.txt plain text: cord-305074-wz17u4e7.txt item: #297 of 440 id: cord-305213-bt0qsbyf author: Zhou, Jian title: Epidemiological and clinical features of 201 COVID-19 patients in Changsha city, Hunan, China date: 2020-08-21 words: 2686 flesch: 44 summary: The occupational composition of the ICU group differed from the non-ICU group, and the number of patients exposed to Wuhan city in the ICU group was significantly higher than that of the non-ICU group, which indicates that the exposure history to Wuhan city may affect the outcome of COVID-19 patients. Patients in the ICU group must breathe more frequently to provide the oxygen required compared to patients in the non-ICU group. keywords: changsha; covid-19; group; icu; patients; study; wuhan cache: cord-305213-bt0qsbyf.txt plain text: cord-305213-bt0qsbyf.txt item: #298 of 440 id: cord-305363-4msd8mqo author: Roselli, Lucia Reis Peixoto title: Utility-Based Multicriteria Model for Screening Patients under the COVID-19 Pandemic date: 2020-09-01 words: 4534 flesch: 45 summary: Also, behavioral studies based on the data Computational and Mathematical Methods in Medicine obtained from the physicians' records may be useful for improving the design of decision information systems and their functionalities. [16] conducted a study to show the potential and impact of three approaches in the use of cost-effective analysis in the scope of breast cancer control: targeting specific groups, by comparing disparities; equity weighting, by valuing high and low health gains differently; and multicriteria decision analysis, giving weights for multiple equity and efficient criteria. keywords: analysis; cost; decision; icu; model; patient; screening; utility cache: cord-305363-4msd8mqo.txt plain text: cord-305363-4msd8mqo.txt item: #299 of 440 id: cord-305434-c1jzty0u author: Roberts, Matthew B. title: COVID‐19 in solid organ transplant recipients: Dynamics of disease progression and inflammatory markers in ICU and non‐ICU admitted patients date: 2020-07-22 words: 1007 flesch: 42 summary: Antibiotics were more frequently given to ICU patients than non-ICU patients (11 vs 9, P = .0021). In addition, among those admitted to the hospital, comparison is made between those admitted to ICU at any point in their admission (ICU patients) and those managed exclusively in a non-ICU, general medical/surgical setting (Non-ICU patients). keywords: covid-19; icu; patients; recipients cache: cord-305434-c1jzty0u.txt plain text: cord-305434-c1jzty0u.txt item: #300 of 440 id: cord-305498-8tmtvw1r author: Singh Saraj, K. title: Modification of Neurosurgical Practice during Corona Pandemic: Our Experience at AIIMS Patna And Long Term Guidelines date: 2020-09-10 words: 4195 flesch: 58 summary: Neurosurgery department formulated their own strategy for successful and covid free management of neurosurgical patients along with zero transmission rate among doctors and staff. Here we are discussing our department response, guidelines, drawbacks and analysis of one of the most important emergency services at AIIMS Patna with safe execution and management of neurosurgical patients. keywords: cases; covid; department; emergency; neurosurgical; pandemic; patients; period; residents cache: cord-305498-8tmtvw1r.txt plain text: cord-305498-8tmtvw1r.txt item: #301 of 440 id: cord-305575-mdy0fcnn author: Zampieri, Fernando Godinho title: How to evaluate intensive care unit performance during the COVID-19 pandemic date: 2020 words: 977 flesch: 37 summary: Why try to predict ICU outcomes? ICU severity of illness scores: APACHE, SAPS and MPM Prospectively defined indicators to improve the safety and quality of care for critically ill patients: a report from the Task Force on Safety and Quality of the European Society of Intensive Care Medicine (ESICM) Understanding intensive care unit benchmarking New perspectives to improve critical care benchmarking What every intensivist should know about prognostic scoring systems and risk-adjusted mortality. key: cord-305575-mdy0fcnn authors: Zampieri, Fernando Godinho; Soares, Marcio; Salluh, Jorge Ibrain Figueira title: How to evaluate intensive care unit performance during the COVID-19 pandemic date: 2020 journal: Rev Bras Ter Intensiva DOI: 10.5935/0103-507x.20200040 sha: doc_id: 305575 cord_uid: mdy0fcnn nan reduce healthcare-associated infections. keywords: care; icu; outcomes; severity cache: cord-305575-mdy0fcnn.txt plain text: cord-305575-mdy0fcnn.txt item: #302 of 440 id: cord-306210-ny3vvu9h author: Clarfield, A. Mark title: Age, ageing, ageism and “age-itation” in the Age of COVID-19: rights and obligations relating to older persons in Israel as observed through the lens of medical ethics date: 2020-11-12 words: 9583 flesch: 52 summary: Without this aid it is difficult for such older persons to cope with social isolation and resulting loneliness. key: cord-306210-ny3vvu9h authors: Clarfield, A. Mark; Jotkowitz, Alan title: Age, ageing, ageism and “age-itation” in the Age of COVID-19: rights and obligations relating to older persons in Israel as observed through the lens of medical ethics date: 2020-11-12 journal: keywords: age; ageism; covid-19; disease; example; health; icu; israel; medical; pandemic; people; persons; ref; risk; society cache: cord-306210-ny3vvu9h.txt plain text: cord-306210-ny3vvu9h.txt item: #303 of 440 id: cord-306315-vt2e0crh author: Elabbadi, Alexandre title: Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (HIV-VIR study) date: 2020-09-14 words: 4743 flesch: 30 summary: Medicine (Baltimore) Respiratory viruses in HIV-infected patients with suspected respiratory opportunistic infection Outcome of critically ill human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy Etiology of pulmonary infections in human immunodeficiency virus-infected inpatients using sputum multiplex real-time polymerase chain reaction Impact of HIV infection and smoking on lung immunity and related disorders Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells Recording of influenza-like illness in UK primary care 1995-2013: cohort study Incidence and risk factors for influenza-like-illness in the UK: online surveillance using Flusurvey Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus Pandemic (H1N1) 2009 influenza virus seroconversion rates in HIV-infected individuals Incidence of respiratory viruses in patients with community-acquired pneumonia admitted to the intensive care unit: results from the Severe Influenza Pneumonia Surveillance (SIPS) project Clinical epidemiology of bocavirus, rhinovirus, two polyomaviruses and four coronaviruses in HIV-infected and HIV-uninfected South African children Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods Virological diagnosis in community-acquired pneumonia in immunocompromised patients Prolonged shedding of rhinovirus and re-infection in adults with respiratory tract illness Chronic rhinoviral infection in lung transplant recipients Persistent human rhinovirus type C infection of the lower respiratory tract in a pediatric cord blood transplant recipient Persistent rhinovirus infection in pediatric hematopoietic stem cell transplant recipients with impaired cellular immunity Viral infection in community-acquired pneumonia: a systematic review and meta-analysis Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8 + T cell response Role of tissue protection in lethal respiratory viral-bacterial coinfection Influenza virus primes mice for pneumonia from Staphylococcus aureus Pneumocystis infection enhances antibodymediated resistance to a subsequent influenza infection Diagnosis and management of respiratory viruses in critically ill adult patients: an international survey of knowledge and practice among intensivists Diagnostic value of microscopic examination of Gram-stained sputum and sputum cultures in patients with bacteremic pneumococcal pneumonia Comparison of sputum and nasopharyngeal swabs for detection of respiratory viruses Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations None. GV had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. Additional information on Material and methods, Table S1 (Panels of mPCR kits used in the two participating ICUs over the 6-year study period), Table S2 (Microbiological investigations performed in 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S3 (Baseline characteristics, behavior during ICU stay, and outcome of 123 HIV-infected patients admitted to the ICU for acute respiratory failure, according to the diagnosis of respiratory virus-associated infection), Table S4 (Multivariate analysis of the risk factors for death at Day-28 in 123 HIV-infected patients admitted to the ICU for acute respiratory failure), Figure S1 (Distribution of the microbiological documentations in 123 HIVinfected patients admitted to the ICU for acute respiratory failure), Figure S2 Admissions to intensive care unit of HIV-infected patients in the era of highly active antiretroviral therapy: etiology and prognostic factors Etiologies and outcome of acute respiratory failure in HIVinfected patients Temporal trends in critical events complicating HIV infection: 1999-2010 multicentre cohort study in France Survival for patients with HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy Pulmonary infections in HIV-infected patients: an update in the 21st century HIV infection and risk for incident pulmonary diseases in the combination antiretroviral therapy era Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study Respiratory viruses in invasively ventilated critically ill patients-a prospective multicenter observational study Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: a single-center retrospective study Virus infection in exacerbations of chronic obstructive pulmonary disease requiring ventilation Procalcitonin algorithm to guide initial antibiotic therapy in acute exacerbations of COPD admitted to the ICU: a randomized multicenter study Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease Community surveillance of respiratory viruses among families in the utah better identification of germs-longitudinal viral epidemiology (BIG-LoVE) study Community-acquired pneumonia requiring hospitalization among U.S. adults Clinical significance of upper airway virus detection in critically ill hematology patients Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Prospective etiological investigation of community-acquired pulmonary infections in hospitalized people living with HIV. keywords: acute; cd4; hiv; icu; infection; patients; study; virus cache: cord-306315-vt2e0crh.txt plain text: cord-306315-vt2e0crh.txt item: #304 of 440 id: cord-307287-zpq6byml author: Poulsen, Nadia Nicholine title: Cyclosporine and COVID‐19: Risk or Favorable? date: 2020-08-10 words: 4462 flesch: 26 summary: Two drugs have shown promising effect on COVID-19 patients, Remdesivir proved in a recent trial to reduce time to recovery, but had no effect on mortality 1 . The first group had a mortality of 50% and the second group only 12.5% thus supporting the idea that continuous use of cyclosporine might be beneficial in COVID-19 patients. keywords: coronavirus; covid-19; cyclosporine; disease; patients; recipients; replication; respiratory; sars; syndrome; transplant cache: cord-307287-zpq6byml.txt plain text: cord-307287-zpq6byml.txt item: #305 of 440 id: cord-308105-u5eri058 author: Qian, Z. title: Between-centre differences for COVID-19 ICU mortality from early data in England date: 2020-04-27 words: 836 flesch: 46 summary: key: cord-308105-u5eri058 authors: Qian, Z.; Alaa, A. M.; van der Schaar, M.; Ercole, A. title: Between-centre differences for COVID-19 ICU mortality from early data in England date: 2020-04-27 journal: nan DOI: 10.1101/2020.04.19.20070722 sha: doc_id: 308105 cord_uid: u5eri058 The high numbers of COVID-19 patients developing severe respiratory failure has placed exceptional demands on ICU capacity around the world. Understanding the determinants of ICU mortality is important for surge planning and shared decision making. keywords: covid-19; icu; mortality cache: cord-308105-u5eri058.txt plain text: cord-308105-u5eri058.txt item: #306 of 440 id: cord-308188-oid3n8qf author: Cuquemelle, E. title: Can procalcitonin help identify associated bacterial infection in patients with severe influenza pneumonia? A multicentre study date: 2011-03-03 words: 2562 flesch: 35 summary: Because of the presumed high frequency of bacterial infection, most hospitalised patients with influenza pneumonia are administered antibiotics, even though bacterial co-infection is considered unlikely However, by excluding patients having received prior antibiotics, thus allowing a more accurate diagnosis of bacterial infection, we believe we have come closer to estimating the frequency and influence of bacterial co-infection in patients with severe influenza A/H1N1 pneumonia. keywords: bacterial; infection; patients; pct cache: cord-308188-oid3n8qf.txt plain text: cord-308188-oid3n8qf.txt item: #307 of 440 id: cord-308303-tgpqnoq2 author: Liu, X. title: Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment date: 2020-04-28 words: 4581 flesch: 42 summary: Every patient had stayed in the intensive care unit for more than three days (herein and after referred to as ICU patients) and had at least three consecutively detected platelet counts data. As shown in table 1, severe thrombocytopenia (PLT≤50×10 9 /L) was observed in 1·1% of non-ICU patients (1/93), whereas it occurred in 41% of ICU patients (25/61), of whom 96% were ICU nonsurvivors (24/25). keywords: covid-19; crrt; figure; heparin; hit; icu; patients; plt; thrombocytopenia cache: cord-308303-tgpqnoq2.txt plain text: cord-308303-tgpqnoq2.txt item: #308 of 440 id: cord-308677-dr9a3ug0 author: Hall, William J. title: Benefits of Intensive Care Unit Hospitalization for Patients Older than 90 Years date: 2020-06-27 words: 1398 flesch: 53 summary: But the reality is, fundamental data on what benefit ICU care might have for older adults were not a paramount decision tool. There have been previous studies with perhaps lower statistical power that have documented mortality rates among older adults hospitalized in ICUs similar to those reported here, but Hass and colleagues 2 have added a decade of hospital experience for the entire country. keywords: icu; mortality; patients; years cache: cord-308677-dr9a3ug0.txt plain text: cord-308677-dr9a3ug0.txt item: #309 of 440 id: cord-309294-ax6sr3zr author: Garrigues, Eve title: Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19 date: 2020-08-25 words: 1012 flesch: 49 summary: Except pain or discomfort, we found no significant difference regarding persistent symptoms and HRQoL between ward patients versus ICU patients. There was no statistically significant difference between ward and ICU groups, but there was a nonsignificant trend towards a reduced proportion of patients returning to work among ICU patients (46.7% versus 77.5%, P=0.061). keywords: covid-19; icu; patients cache: cord-309294-ax6sr3zr.txt plain text: cord-309294-ax6sr3zr.txt item: #310 of 440 id: cord-309378-sfr1x0ob author: Röst, Gergely title: Early Phase of the COVID-19 Outbreak in Hungary and Post-Lockdown Scenarios date: 2020-06-30 words: 10531 flesch: 51 summary: Benchmarking the CFR to other countries, we estimated underascertainment rate to be 10-20 times, and the true cumulative number of COVID-19 cases to be between 32,840 and 65,680. R Package Version 1.12.8 Shiny: Web Application Framework for R Real-Time Epidemiology of COVID-19 in Hungary (A Magyarországi Koronavírus jáRvány Valós Idejű Epidemiológiája-In Hungarian) Real-Time Epidemiology of COVID-19 in Hungary (A Magyarországi Koronavírus járváNy Valós Idejű A New Framework and Software to Estimate Time-Varying Reproduction Numbers During Epidemics Different Epidemic Curves for Severe Acute Respiratory Syndrome Reveal Similar Impacts of Control Measures How Generation Intervals Shape the Relationship Between Growth Rates and Reproductive Numbers The Effective Reproduction Number of Pandemic Influenza: Prospective Estimation Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan Effective Reproduction Number Estimation Estimating in real time the efficacy of measures to control emerging communicable diseases Serial Interval of COVID-19 Among Publicly Reported Confirmed Cases Epidemiological characteristics of COVID-19 cases in Italy and estimates of the reproductive numbers one month into the epidemic Serial interval of novel coronavirus (COVID-19) infections The R0 package: A toolbox to estimate reproduction numbers for epidemic outbreaks R0: Estimation of R0 and Real-Time Reproduction Number from Epidemics. keywords: age; cases; contact; control; covid-19; disease; epidemic; figure; model; number; peak; population; reproduction; time; transmission cache: cord-309378-sfr1x0ob.txt plain text: cord-309378-sfr1x0ob.txt item: #311 of 440 id: cord-309733-x4crng5j author: Dhesi, Z. title: Organisms causing secondary pneumonias in COVID-19 patients at 5 UK ICUs as detected with the FilmArray test date: 2020-06-23 words: 3633 flesch: 37 summary: FilmArray test results and clinical microbiology results were recorded, along with a brief statement of the reason for FilmArray testing. Accordingly, we aimed to define the bacteria causing secondary pneumonias in COVID-19 ICU patients using the FilmArray Pneumonia Panel, and to determine this tests potential in COVID-19 management. keywords: covid-19; filmarray; license; patients; pneumonia; preprint; results cache: cord-309733-x4crng5j.txt plain text: cord-309733-x4crng5j.txt item: #312 of 440 id: cord-310089-kfxtctn3 author: Gomez, Sofia title: Benchmarking Critical Care Well-Being: Before and After the Coronavirus Disease 2019 Pandemic date: 2020-10-21 words: 4560 flesch: 42 summary: Job burnout An official Critical Care Societies Collaborative Statement: Burnout syndrome in critical care healthcare professionals: A call for action Burnout and joy in the profession of critical care medicine Burnout syndrome in critical care nursing staff High level of burnout in intensivists: Prevalence and associated factors The relationship between burnout, depression, and anxiety: A systematic review and meta-analysis Association between physician burnout and patient safety, professionalism, and patient satisfaction: A systematic review and meta-analysis Still an epidemic: The burnout syndrome in hospital registered nurses Physician burnout: Contributors, consequences and solutions Measuring burnout in emergency medicine physician assistants Factors associated with burnout among US hospital clinical pharmacy practitioners: Results of a nationwide pilot survey Academic Leaders in Critical Care Medicine (ALCCM) Task Force of the Society of the Critical Care Medicine: Workforce, workload, and burnout among intensivists and advanced practice providers: A narrative review Assessing and addressing practitioner burnout: Results from an advanced practice registered nurse health and well-being study Being and Resilience: Validated Instruments to Assess Work-Related Dimensions of Well-Being A brief instrument to assess both burnout and professional fulfillment in physicians: Reliability and validity, including correlation with self-reported medical errors, in a sample of resident and practicing physicians Burnout, and fulfillment, in the profession of critical care medicine Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support Utility of a brief screening tool to identify physicians in distress Ability of a 9-item well-being index to identify distress and stratify quality of life in US workers Executive leadership and physician wellbeing: Nine organizational strategies to promote engagement and reduce burnout Job satisfaction and burnout among intensive care unit nurses and physicians Feasibility and acceptability of a resilience training program for intensive care unit nurses Effect of a professional coaching intervention on the well-being and distress of physicians: A pilot randomized clinical trial Enhancing meaning in work: A prescription for preventing physician burnout and promoting patient-centered care Impact of organizational leadership on physician burnout and satisfaction Prevalence, risk factors and consequences of severe burnout syndrome in ICU The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses We are grateful to our colleagues for participating in this inaugural well-being survey to understand burnout and fulfillment among critical care healthcare professionals at the University of Pennsylvania Health System. None. MEASUREMENTS AND MAIN RESULTS: Burnout was present in 50% of ICU clinicians, ranging from 42% for critical care physicians to 55% for advanced practice providers. keywords: burnout; care; fulfillment; nurses; pandemic; physicians; professional; work cache: cord-310089-kfxtctn3.txt plain text: cord-310089-kfxtctn3.txt item: #313 of 440 id: cord-310457-l3d1dc93 author: Robinson, A. J. title: A modification to the Maquet Flow-i anaesthesia machinefor ICU ventilation date: 2020-04-11 words: 3090 flesch: 53 summary: https://doi.org/10.1101/2020.04.06.20054882 doi: medRxiv preprint single patient use. While anaesthesia machines are able to run for short periods of time without scavenging, they are designed to be used with a constant low-level vacuum applied via the Anaesthesia Gas Scavenging (AGS) port and in a positive pressure Operating Room environment. keywords: flow; license; machine; patient; preprint; system cache: cord-310457-l3d1dc93.txt plain text: cord-310457-l3d1dc93.txt item: #314 of 440 id: cord-310621-wnd47uss author: Singh, Shalendra title: Challenges faced in establishing a dedicated 250 bed COVID-19 intensive care unit in a temporary structure date: 2020-11-06 words: 2015 flesch: 40 summary: In its 2020 guidelines on ICU planning and designing in India, the Indian Society of 22 Critical Care Medicine(ISCCM) has laid down recommendations for the setting up of an ICU, 23 including the initial planning, decisions about ICU level, number of beds, ICU design, equipment 24 provision, support system recommendations, manning plans, human resource development, and 25 environmental planning among others(8). key: cord-310621-wnd47uss authors: Singh, Shalendra; Cherian Ambooken, George; Setlur, Rangraj; Paul, Shamik Kr; Kanitkar, Madhuri; Singh Bhatia, Surinder; singh Kanwar, Ratnesh title: Challenges faced in establishing a dedicated 250 bed COVID-19 intensive care unit in a temporary structure date: 2020-11-06 journal: nan DOI: 10.1016/j.tacc.2020.10.006 sha: doc_id: 310621 cord_uid: wnd47uss An Intensive Care Unit (ICU) is an organized system for the provision of care to critically ill patients that provides intensive and specialized medical and nursing care, an enhanced capacity for monitoring, and multiple modalities of physiologic organ support to sustain life during a period of life-threatening organ system insufficiency. keywords: care; design; equipment; hospital; icu cache: cord-310621-wnd47uss.txt plain text: cord-310621-wnd47uss.txt item: #315 of 440 id: cord-311074-j3fw4dfc author: Alviset, Sophie title: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study date: 2020-10-14 words: 4848 flesch: 44 summary: Optimal respiratory support for COVID-19 patients presenting with acute hypoxemic respiratory failure, however, remains unknown. The role of face-mask CPAP in managing acute hypoxemic respiratory failure in COVID-19 patients warrants further investigation in larger prospective studies and comparison with other ways to manage hypoxemic respiratory failure, such as high flow nasal oxygen cannula keywords: covid-19; cpap; failure; hypoxemic; icu; intubation; patients; respiratory; study; ventilation cache: cord-311074-j3fw4dfc.txt plain text: cord-311074-j3fw4dfc.txt item: #316 of 440 id: cord-311159-qatiqnac author: Kupczyk, Maciej title: Life threatening pneumonia in a lupus patient: a case report date: 2008-07-31 words: 1618 flesch: 42 summary: A fulminant course of the disease, an interstitial pattern in a high resolution computed tomography (HRCT) and negative repeated sputum, blood and bronchoaspirate cultures enabled diagnosis of fulminant lupus pneumonitis. Fulminant lupus pneumonitis is a rare but potentially life threatening complication of SLE. keywords: lupus; patient; pneumonitis; pulmonary; sle cache: cord-311159-qatiqnac.txt plain text: cord-311159-qatiqnac.txt item: #317 of 440 id: cord-311872-09jzyyin author: Effenberger, Maria title: Systemic inflammation as fuel for acute liver injury in COVID-19 date: 2020-08-10 words: 2973 flesch: 45 summary: Of all hospitalized COVID-19 patients, 41 (42%) showed elevated aspartate aminotransferase (AST) concentration. COVID-19 patients with elevated AST exhibited significantly higher IL-6 (p< 0.001), ferritin (p< 0.001), LDH (p< 0.001) and CRP (p < 0.05) serum concentrations compared to patients with normal AST. keywords: ast; covid-19; fig; icu; il-6; injury; liver; p<0.001; patients cache: cord-311872-09jzyyin.txt plain text: cord-311872-09jzyyin.txt item: #318 of 440 id: cord-312467-kbhljong author: Boilève, Alice title: COVID-19 management in a cancer center: the ICU storm date: 2020-07-31 words: 4119 flesch: 44 summary: In this regard, some cancer centers have their own ICU (dedicated to cancer patients only) that would receive COVID-19 patients in the context of pandemic. They received a time-limited training resulting in a 2-day observation course with their ICU colleagues before caring ICU patients. keywords: beds; cancer; care; covid-19; hospital; icu; pandemic; patients; workers cache: cord-312467-kbhljong.txt plain text: cord-312467-kbhljong.txt item: #319 of 440 id: cord-312864-km07zhn1 author: Potalivo, A. title: Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study date: 2020-08-15 words: 5412 flesch: 46 summary: key: cord-312864-km07zhn1 authors: Potalivo, A.; Montomoli, J.; Facondini, F.; Sanson, G.; Lazzari Agli, L. A.; Perin, T.; Cristini, F.; Cavagna, E.; De Giovanni, R.; Biagetti, C.; Panzini, I.; Ravaiolo, C.; Bitondo, M.; Guerra, D.; Giuliani, G.; Mosconi, E.; Guarino, S.; Marchionni, E.; Gangitano, G.; Valentini, I.; Giampaolo, L.; Muratori, F.; Nardi, G. title: Sixty-day mortality among 520 Italian hospitalized COVID-19 patients according to the adopted ventilatory strategy in the context of an integrated multidisciplinary clinical organization: a population-based cohort study date: 2020-08-15 journal: nan DOI: 10.1101/2020.08.13.20174615 sha: doc_id: 312864 cord_uid: km07zhn1 Background: Among COVID-19 patients, the decision of which ventilation strategy to adopt is crucial and not guided by existing outcome evidence. The percentage of COVID-19 patients requiring non-invasive (NIV) or invasive mechanical ventilation (IMV) is unclear and strongly affected by the hospital organization and the availability of resources. keywords: covid-19; days; icu; imv; mortality; niv; oxygen; patients; study cache: cord-312864-km07zhn1.txt plain text: cord-312864-km07zhn1.txt item: #320 of 440 id: cord-313028-0nhgxoim author: Huang, Chaolin title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China date: 2020-01-24 words: 4834 flesch: 46 summary: KDIGO clinical practice guideline for acute kidney injury CDC definitions for nosocomial infections Association between cardiac injury and mortality in hospitalized patients infected with avian influenza A (H7N9) virus Coronaviruses post-SARS: update on replication and pathogenesis A major outbreak of severe acute respiratory syndrome in Hong Kong Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques SARS: systematic review of treatment effects Corticosteroids as adjunctive therapy in the treatment of influenza Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Origin and evolution of pathogenic coronaviruses Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting We acknowledge all health-care workers involved in the diagnosis and treatment of patients in Wuhan; we thank the Chinese National Health Commission for coordinating data collection for patients with 2019-nCoV infection; we thank WHO and the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) for sharing data collection templates publicly on the website; and we thank Prof Chen Wang and Prof George F Gao for guidance in study design and interpretation of results. Plasma levels of IL5, IL12p70, IL15, Eotaxin, and RANTES were similar between healthy adults and patients infected with 2019-nCoV. Further comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNFα were higher in ICU patients than non-ICU patients. keywords: acute; clinical; coronavirus; data; icu; infection; mers; ncov; novel; patients; respiratory; sars cache: cord-313028-0nhgxoim.txt plain text: cord-313028-0nhgxoim.txt item: #321 of 440 id: cord-313136-ab56mg6j author: Pavoni, Vittorio title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia date: 2020-05-11 words: 2629 flesch: 39 summary: [3] [4] ; moreover, a pooled analysis showed that D-dimer values are considerably higher in COVID-19 patients with severe disease than those without [5] . ROTEM analysis confirms that patients with severe COVID-19 pneumonia had a hypercoagulation state that persisted over time. keywords: coagulation; covid-19; icu; patients; sepsis; time cache: cord-313136-ab56mg6j.txt plain text: cord-313136-ab56mg6j.txt item: #322 of 440 id: cord-313980-jutof78v author: van de Veerdonk, F. L. title: A systems approach to inflammation identifies therapeutic targets in SARS-CoV-2 infection date: 2020-05-24 words: 4687 flesch: 45 summary: Unsupervised clustering analysis of the PEA proteins that significantly differ between ICU and non ICU, C-reactive protein (CRP), D-dimer, ferritin, C3a, C3c and TCC, revealed that ICU patients cluster separately from non ICU patients, but that within these clusters no significantly different profiles could be identified ( Figure 3A ). Although circulating ferritin concentrations were also increased in ICU patients as compared to non ICU COVID-19 patients, no statistically significant differences were observed (1470 µg/l keywords: copyright; covid-19; holder; icu; license; medrxiv; medrxiv preprint; patients; perpetuity; preprint; version cache: cord-313980-jutof78v.txt plain text: cord-313980-jutof78v.txt item: #323 of 440 id: cord-314349-rhm1ii3d author: Kraft, Miquel title: Incidence, features, outcome and impact on health system of de-novo abdominal surgical diseases in patients admitted with COVID-19 date: 2020-08-28 words: 2715 flesch: 41 summary: Sub-analyses were performed with a consecutive group of COVID-19 patients admitted during the study period, who did not require surgical consultation. COVID-19 patients might develop de-novo surgical diseases during hospitalization, requiring surgical consultation and treatment. keywords: consultation; covid-19; diseases; icu; patients; surgery cache: cord-314349-rhm1ii3d.txt plain text: cord-314349-rhm1ii3d.txt item: #324 of 440 id: cord-314465-5beuvt8u author: Hardy, Michaël title: Prothrombotic Hemostasis Disturbances in Patients with Severe COVID-19: Individual daily data date: 2020-11-10 words: 1591 flesch: 25 summary: Raw: Public repository Laboratory data: Clinical laboratory tests that describe disturbances of haemostasis of ICU patients, severely affected with CoViD-19: primary haemostasis (platelet count, von Willebrand factor antigen and activity; ADAMTS-13 activity); coagulation (prothrombin time, Clauss fibrinogen, clotting factors II, V and VIII levels, in vitro thrombin potential), natural anticoagulants (antithrombin activity, protein C activity, free protein S antigen, total and free tissue factor pathway inhibitor antigens); and fibrinolysis (D-dimers levels, PAI-1 activity, global fibrinolytic capacity). Demographic and clinical characteristics of observed ICU patients are shown in Table 1 . keywords: activity; icu; levels; patients; sta; time cache: cord-314465-5beuvt8u.txt plain text: cord-314465-5beuvt8u.txt item: #325 of 440 id: cord-314737-2fun90ze author: Cardoso, Filipe S. title: Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study date: 2020-07-28 words: 855 flesch: 39 summary: key: cord-314737-2fun90ze authors: Cardoso, Filipe S.; Papoila, Ana L.; Machado, Rita Sá; Fidalgo, Pedro title: Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study date: 2020-07-28 journal: Crit Care DOI: 10.1186/s13054-020-03173-1 sha: doc_id: 314737 cord_uid: 2fun90ze nan Previous studies have identified risk factors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) severe outcomes preferentially among hospitalized patients; therefore, they may have understated the denominator of such estimations [1, 2] . Cases with ICU admission or nonsurvivors had higher median age (80 vs. 49 years; P < 0.001) and were more frequently men (54.7% vs. 40.8%; P < 0.001) than those that were not admitted to the ICU and survived. keywords: admission; cases; icu cache: cord-314737-2fun90ze.txt plain text: cord-314737-2fun90ze.txt item: #326 of 440 id: cord-314826-usfvulc2 author: Sharifipour, Ehsan title: Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU date: 2020-09-01 words: 4346 flesch: 38 summary: key: cord-314826-usfvulc2 authors: Sharifipour, Ehsan; Shams, Saeed; Esmkhani, Mohammad; Khodadadi, Javad; Fotouhi-Ardakani, Reza; Koohpaei, Alireza; Doosti, Zahra; EJ Golzari, Samad title: Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU date: 2020-09-01 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05374-z sha: doc_id: 314826 cord_uid: usfvulc2 BACKGROUND: COVID-19 is known as a new viral infection. To date, few studies have investigated bacterial superinfections in COVID-19 patients. keywords: aureus; bacteria; baumannii; covid-19; icu; infections; mortality; patients; staphylococcus; study cache: cord-314826-usfvulc2.txt plain text: cord-314826-usfvulc2.txt item: #327 of 440 id: cord-315143-s0nfejq8 author: Kumar, Abhyuday title: COVID-19 pandemic and the need for objective criteria for ICU admissions date: 2020-06-01 words: 390 flesch: 52 summary: [3] [4] [5] Moreover, patients with two or more comorbidities have significantly escalated risks of ICU admission, invasive ventilation, and mortality as compared with those who had single comorbidity, and even more so as compared with those without any comorbidity. Early recognition of the patients who will require ICU admission and will benefit most from it is of utmost importance. keywords: covid-19; patients cache: cord-315143-s0nfejq8.txt plain text: cord-315143-s0nfejq8.txt item: #328 of 440 id: cord-315864-zadogqiu author: Davido, Benjamin title: nImpact of medical care including anti-infective agents use on the prognosis of COVID-19 hospitalized patients over time date: 2020-08-02 words: 3623 flesch: 39 summary: Indeed, in the absence of a clear recommendation for treatment initiation, it is difficult to assume or to invalidate the effect of anti-infective agents on the prognosis of COVID-19 patients. However, it was carried out in a hospital specialized for decades in the Moreover, considering inherent limitation of a descriptive study with a limited sample size (n=132), we could not infer causality in the association between the use of AZI±HCQ and the ameliorated prognosis in COVID-19 patients. keywords: agents; azithromycin; covid-19; hcq; icu; patients; study; treatment cache: cord-315864-zadogqiu.txt plain text: cord-315864-zadogqiu.txt item: #329 of 440 id: cord-316504-od7zex3f author: Savary, D. title: Reliability and limits of transport-ventilators to safely ventilate severe patients in special surge situations. date: 2020-10-09 words: 4335 flesch: 42 summary: Pneumatic transport ventilators have been used for decades both for in-and out-of-hospital transport. In the context of mass casualty, as experienced with the COVID-19 crisis, pneumatic transport ventilators could be used to extend the possibility to manage intubated patients in case of ICU beds shortage. keywords: cmh; medrxiv; preprint; set; transport; ventilators cache: cord-316504-od7zex3f.txt plain text: cord-316504-od7zex3f.txt item: #330 of 440 id: cord-316647-jj8anf5g author: Shang, You title: Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China date: 2020-06-06 words: 13606 flesch: 35 summary: However, considering the suggestion that restrictive fluid volume management strategy should be adopted for COVID-19 patients complicated by ARDS based on the premise of sufficient tissue perfusion, we suggest CRRT initiation in severe patients within 24 h when they show rank 2 AKI under KDIGO criteria or accompanied with cytokine storm syndrome. There are still no targeted therapies for COVID-19 patients. keywords: acute; aki; ards; care; coronavirus; covid-19; covid-19 patients; disease; expert; grade; infection; lung; mortality; patients; rationale; recommendation; risk; sedation; study; syndrome; therapy; treatment; use; ventilation cache: cord-316647-jj8anf5g.txt plain text: cord-316647-jj8anf5g.txt item: #331 of 440 id: cord-316681-b46ycocg author: Rutsaert, Lynn title: COVID-19-associated invasive pulmonary aspergillosis date: 2020-06-01 words: 1235 flesch: 38 summary: SARS-CoV-2 infection among travelers returning from Wuhan, China Invasive pulmonary aspergillosis The clinical spectrum of pulmonary aspergillosis Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study Invasive pulmonary aspergillosis complicating severe influenza: epidemiology, diagnosis and treatment Diagnosing invasive pulmonary aspergillosis in ICU patients: putting the puzzle together Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group Inhaled amphotericin B as aspergillosis prophylaxis in hematologic disease: an update. In our 24-bedded mixed ICU, we have encountered an unexpectedly high number of COVID-19 patients developing invasive pulmonary aspergillosis. keywords: aspergillosis; icu; ipa; patients cache: cord-316681-b46ycocg.txt plain text: cord-316681-b46ycocg.txt item: #332 of 440 id: cord-316829-wm6y6uwm author: Vargas, Maria title: Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients date: 2020-05-18 words: 903 flesch: 50 summary: On 6 April, the worldwide ICU admission rate of COVID-19 patients was 3% ranging from 1% of total cases in Africa to 4% of total cases in Europe [4] . From 10 March, our ICU is completely dedicated to COVID-19 patients, and actually, it is one of the largest cohorted ICU in the south of Italy admitting 12 positive critically ill patients (Fig. 1 ). keywords: covid-19; icu; patients cache: cord-316829-wm6y6uwm.txt plain text: cord-316829-wm6y6uwm.txt item: #333 of 440 id: cord-316938-64jxtg9y author: Blasi, Annabel title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation date: 2020-08-06 words: 3076 flesch: 36 summary: The high thrombosis risk in COVID-19 patients has been linked to a hypercoagulable state that has not been well-defined. Test results were compared between COVID-19 patients and healthy controls, and between patients admitted to the ICU and the ward, using the Mann-Whitney U test. keywords: article; coagulation; covid-19; icu; levels; patients; plasma; thrombin cache: cord-316938-64jxtg9y.txt plain text: cord-316938-64jxtg9y.txt item: #334 of 440 id: cord-318920-njurbf3d author: Romana Ponziani, Francesca title: Liver involvement is not associated with mortality: results from a large cohort of SARS‐CoV‐2 positive patients date: 2020-07-06 words: 2269 flesch: 44 summary: This study demonstrates that in patients without severe chronic liver disease liver involvement during SARS-CoV-2 infection is usually mild, is not associated with increased risk of ICU admission or mortality, and tends to resolve over time. Alterations of liver tests worsened within 15 days after hospitalization; however, in patients with the longest median follow‐up, the prevalence of liver tests alterations decreased over time, returning similar to that of baseline. keywords: admission; liver; patients; sars; tests cache: cord-318920-njurbf3d.txt plain text: cord-318920-njurbf3d.txt item: #335 of 440 id: cord-318954-pj5lsvsa author: Arabi, Yaseen title: Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol date: 2015-11-19 words: 3968 flesch: 43 summary: The study also has an independent data safety monitoring board (DSMB) which is responsible for reviewing reports submitted to the regarding safety of study patients, protocol adherence and may making recommendations to continue or terminate the study based on safety analysis results. Clinical and laboratory data will be collected at baseline, 30 min after first dose, 30 min after second dose, study days 1, 3, 5, 7, 14, and 28. keywords: cov; days; infection; mers; patients; plasma; study; therapy cache: cord-318954-pj5lsvsa.txt plain text: cord-318954-pj5lsvsa.txt item: #336 of 440 id: cord-318984-8m9ygzn5 author: Chen, Yin-Yin title: Surveillance on secular trends of incidence and mortality for device–associated infection in the intensive care unit setting at a tertiary medical center in Taiwan, 2000–2008: A retrospective observational study date: 2012-09-10 words: 4304 flesch: 40 summary: In the analysis of long-term changes in infection rates or mortality rates, we must consider whether changes in the population, advances in laboratory diagnostic techniques, changes in exposure to risk factors, microbial culture and other factors lead to increased or decreased rates. MRSA infection rates have been reduced by year from 2006. keywords: control; dai; hospital; icu; infection; mortality; patients; rates; study; surveillance cache: cord-318984-8m9ygzn5.txt plain text: cord-318984-8m9ygzn5.txt item: #337 of 440 id: cord-319427-jkxioc1j author: Mughal, Mohsin Sheraz title: The prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG antibodies in intensive care unit (ICU) healthcare personnel (HCP) and its implications—a single-center, prospective, pilot study date: 2020-06-12 words: 859 flesch: 46 summary: key: cord-319427-jkxioc1j authors: Mughal, Mohsin Sheraz; Kaur, Ikwinder Preet; Patton, Chandler D.; Mikhail, Nagy H.; Vareechon, Chairut; Granet, Kenneth M. title: The prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG antibodies in intensive care unit (ICU) healthcare personnel (HCP) and its implications—a single-center, prospective, pilot study date: 2020-06-12 journal: Infection control and hospital epidemiology DOI: 10.1017/ice.2020.298 sha: doc_id: 319427 cord_uid: jkxioc1j nan To the Editor-Healthcare personnel (HCP), including practitioners, nursing staff, respiratory therapists, and the pronepositioning team caring for coronavirus disease 2019 (COVID-19) patients in the intensive care unit (ICU) are considered to have a high risk of exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we investigated the seroconversion of asymptomatic SARS-CoV-2 infection in ICU HCP exposed to critically ill COVID-19 patients. keywords: cov-2; hcp; icu; sars cache: cord-319427-jkxioc1j.txt plain text: cord-319427-jkxioc1j.txt item: #338 of 440 id: cord-319615-p2labgd8 author: Schulman, Sam title: Coronavirus Disease 2019, Prothrombotic Factors, and Venous Thromboembolism date: 2020-05-11 words: 3049 flesch: 41 summary: Most of the events (n ¼ 29) were in ICU patients and 21 of the 33 events were symptomatic with the remainder found through screening for DVT. 22 Stroke was also, albeit at a slightly lower incidence, diagnosed in sepsis patients remaining in sinus rhythm. keywords: care; covid-19; icu; incidence; patients; thromboembolism; venous cache: cord-319615-p2labgd8.txt plain text: cord-319615-p2labgd8.txt item: #339 of 440 id: cord-319642-ceur0n0b author: Hamdan Alshehri, Hanan title: Factors influencing the integration of a palliative approach in intensive care units: a systematic mixed-methods review date: 2020-07-22 words: 5714 flesch: 39 summary: key: cord-319642-ceur0n0b authors: Hamdan Alshehri, Hanan; Olausson, Sepideh; Öhlén, Joakim; Wolf, Axel title: Factors influencing the integration of a palliative approach in intensive care units: a systematic mixed-methods review date: 2020-07-22 journal: BMC Palliat Care DOI: 10.1186/s12904-020-00616-y sha: doc_id: 319642 cord_uid: ceur0n0b BACKGROUND: While a palliative approach is generally perceived to be an integral part of the intensive care unit (ICU), the provision of palliative care in this setting is challenging. Multiple electronic databases were used, and the following search terms were utilized: implementation, palliative care, and intensive care unit. keywords: approach; care; factors; family; icu; integration; intensive; palliative; patients; studies; study cache: cord-319642-ceur0n0b.txt plain text: cord-319642-ceur0n0b.txt item: #340 of 440 id: cord-320572-94fvtj4a author: Wendel Garcia, Pedro David title: Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort date: 2020-07-06 words: 5418 flesch: 38 summary: Following the critical developments in ICUs in regions experiencing early inception of the pandemic, the European-based, international RIsk Stratification in COVID-19 patients in the Intensive Care Unit (RISC-19-ICU) registry was created to provide near real-time assessment of patients developing critical illness due to COVID-19. Following the critical spread of the disease in China, Italy and Spain, on March 13, 2020 the European-based RIsk Stratification in COVID-19 patients in the ICU (RISC-19-ICU) registry was launched to allow nearreal time assessment of the main clinical characteristics of critically ill patients during the emerging COVID-19 pandemic. keywords: acute; analysis; care; covid-19; data; disease; icu; model; mortality; patients; registry; study; survivors cache: cord-320572-94fvtj4a.txt plain text: cord-320572-94fvtj4a.txt item: #341 of 440 id: cord-321149-hffj7s4o author: Schmidt, Matthieu title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 words: 5370 flesch: 41 summary: Systemic inflammatory response syndrome is a major contributor to COVID-19-associated coagulopathy: insights from a prospective single center cohort study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Severe pulmonary embolism in COVID-19 patients: a call for increased awareness High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc Bayesian analysis of a randomized clinical trial Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19) Extracorporeal life support organization coronavirus disease 2019 interim guidelines: a consensus document from an international group of interdisciplinary extracorporeal membrane oxygenation providers Preparing for the most critically ill patients with COVID-19: the potential role of extracorporeal membrane oxygenation Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): pooled analysis of early reports Extracorporeal membrane oxygenation for coronavirus disease 2019-induced acute respiratory distress syndrome: a multicenter descriptive study COVID-19, ECMO, and lymphopenia: a word of caution Clinical management of severe acute respiratory infection when COVID-19 disease is suspected The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material Emergency circulatory support in refractory cardiogenic shock patients in remote institutions: a pilot study (the cardiac-RESCUE program) Retrieval of severe acute respiratory failure patients on extracorporeal membrane oxygenation: any impact on their outcomes? keywords: ards; care; covid-19; ecmo; extracorporeal; hospital; icu; membrane; oxygenation; patients; pressure; state cache: cord-321149-hffj7s4o.txt plain text: cord-321149-hffj7s4o.txt item: #342 of 440 id: cord-321472-n4nnmlv1 author: Oliveira, E. title: ICU Outcomes and Survival in Patients with Severe COVID-19 in the Largest Health Care System in Central Florida date: 2020-08-31 words: 4020 flesch: 41 summary: No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 Convalescent plasma as a potential therapy for COVID-19 Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients with Acute Respiratory Distress Syndrome: A Randomized Clinical Trial Prone positioning in severe acute respiratory distress syndrome The Surviving Sepsis Campaign Bundle: 2018 update Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease A study on the efficacy of APACHE-IV for predicting mortality and length of stay in an intensive care unit in Iran Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Management of COVID-19 Respiratory Distress Past and Present ARDS Mortality Rates: A Systematic Review COVID-19 and African Americans The Relationship of Health Insurance and Mortality: Is Lack of Insurance deadly? Effects of temperature variation and humidity on the death of COVID-19 in Wuhan Innovation and Transformation in the Response to Covid-19: Seven Areas Where Clinicians Need to Lead Clinical outcomes in COVID-19 patients treated with tocilizumab: An individual patient data systematic review Treatment with Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): Pooled analysis of early reports Evaluating the efficacy of dexamethasone in the treatment of patients with persistent acute respiratory distress syndrome: study protocol for a randomized controlled trial Dexamethasone treatment for the acute respiratory distress syndrome: a multicenter, randomized controlled trial We would like to acknowledge the following AdventHealth Critical Care Consortium Research Observations from Wuhan have shown mortality rates of approximately 52% in COVID-19 patients with ARDS keywords: care; covid-19; icu; license; mortality; outcomes; patients; preprint; study cache: cord-321472-n4nnmlv1.txt plain text: cord-321472-n4nnmlv1.txt item: #343 of 440 id: cord-321735-c40m2o5l author: Manca, Davide title: A simplified math approach to predict ICU beds and mortality rate for hospital emergency planning under Covid-19 pandemic date: 2020-06-04 words: 7174 flesch: 46 summary: Finally, the first derivatives of the reverse logistic and Gompertz models are respectively: The models reported in Section 2.3 can be selected and used critically according to their performance and consistency with real data published daily in most countries. Last available real data on 30-Apr. Equally, the reverse logistic and reverse Gompertz models predict that for Italy the descent below the 10% threshold of ICU patients will occur on 25-May and 28-May respectively (i.e. 52 and 55 days after the maximum plateau, which is also at days 94 and 97 respectively). keywords: beds; data; icu; icu beds; maximum; models; number; pandemic; patients; phenomenon; plateau cache: cord-321735-c40m2o5l.txt plain text: cord-321735-c40m2o5l.txt item: #344 of 440 id: cord-322167-cpjkltsu author: Stubington, Thomas J. title: Tracheotomy in COVID‐19 patients: Optimizing patient selection and identifying prognostic indicators date: 2020-05-22 words: 2682 flesch: 45 summary: This is the first report of patient outcomes following tracheotomy in COVID-19 patients, and on the basis of our institutional experience we propose criteria that offer a pragmatic solution to facilitate patient care whilst minimizing risks to health care workers. 3, 4 Median ICU stay for COVID-19 patients varies widely between countries ranging between 4 and over 20 days. keywords: covid-19; fio; patients; peep; tracheotomy cache: cord-322167-cpjkltsu.txt plain text: cord-322167-cpjkltsu.txt item: #345 of 440 id: cord-322243-5js5nudx author: Mac, S. title: COVID-19 Demographics, Acute Care Resource Use and Mortality by Age and Sex in Ontario, Canada: Population-based Retrospective Cohort Analysis date: 2020-11-06 words: 3589 flesch: 49 summary: Despite these limitations, to our knowledge, this study is the first to describe COVID-19 case demographics, acute care use, mortality and LOS stratified by age and sex over seven months of the pandemic in Ontario, Canada. The objective of our study was to describe COVID-19 cases in Ontario between March 1, 2020 and September 30, 2020, and to provide estimates of age-and sex-specific acute care resource utilization (hospitalization, ICU admission, invasive mechanical ventilation (IMV)), length of stay (LOS), and mortality. keywords: age; care; cases; covid-19; license; preprint cache: cord-322243-5js5nudx.txt plain text: cord-322243-5js5nudx.txt item: #346 of 440 id: cord-322533-adqqm0n9 author: Sha, Dexuan title: Spatiotemporal analysis of medical resource deficiencies in the U.S. under COVID-19 pandemic date: 2020-10-14 words: 5194 flesch: 44 summary: [9, 10] . Are U.S. medical resources enough to handle the worst scenario during this crisis? In this study, we (1) conduct a medical data analysis, and re-evaluate the spatial distribution of medical resource features (hospital beds, ICU beds, and CCS) at county level; (2) develop two Medical Resource Deficiency Indices (MRDI and MRDI d ) by linking positive COVID-19 infections and local medical resources to measure local medical burden; and (3) develop a data-driven dynamic spatiotemporal framework to visualize and analyze the MRDI /MRDI keywords: beds; care; county; covid-19; data; icu; level; mrdi; number; patients; u.s cache: cord-322533-adqqm0n9.txt plain text: cord-322533-adqqm0n9.txt item: #347 of 440 id: cord-323180-3ih0i81s author: Pardo, Emmanuel title: Nutritional support for critically ill patients with COVID-19: New strategy for a new disease? date: 2020-10-12 words: 1079 flesch: 35 summary: Expert groups suggest starting, in high risk patients, at 25% of caloric target, regardless of nutrition route, and increasing slowly while closely monitoring serum phosphate, magnesium and potassium, especially during the first 72 hours of ICU stay. In case of formal contraindication to EN or severe feeding intolerance, refractory to prokinetic treatment or post-pyloric tube, total parenteral nutrition should be introduced either early in malnourished patients or at day 4-7 in low nutritional risk patients. keywords: covid-19; icu; nutrition; patients cache: cord-323180-3ih0i81s.txt plain text: cord-323180-3ih0i81s.txt item: #348 of 440 id: cord-323898-054gv684 author: Khan, Anas A. title: Survival and Estimation of Direct Medical Costs of Hospitalized COVID-19 Patients in the Kingdom of Saudi Arabia (Short Title: COVID-19 Survival and Cost in Saudi Arabia) date: 2020-10-13 words: 3351 flesch: 51 summary: Presenting Characteristics, Comorbidities, and Outcomes among 5700 Patients Hospitalized with COVID-19 in the Survival analysis of hospital length of stay of novel coronavirus (COVID-19) pneumonia patients in Sichuan, China Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: A prospective cohort study Predictors of mortality in hospitalized COVID-19 patients: A systematic review and meta-analysis Prevalence and risk factors of mortality among hospitalized patients with COVID-19: This higher risk of mortality among ICU patients aligns with the findings of research studies among hospitalized COVID-19 patients [23] . keywords: cost; covid-19; icu; mortality; patients; saudi; survival cache: cord-323898-054gv684.txt plain text: cord-323898-054gv684.txt item: #349 of 440 id: cord-324764-w68y4fjw author: Rodriguez-Rubio, Miguel title: The Role of the Pediatric Intensivist in the Coronavirus Disease 2019 Pandemic date: 2020-05-20 words: 2084 flesch: 35 summary: We thank all of our colleagues in adult and pediatric critical care around the world for the inspiring high-quality care they continue to provide during this pandemic. Questions remain as to whether admitting adult patients to PICUs or deploying pediatric intensivists to adult ICUs should be the preferred model. keywords: adult; care; covid-19; icu; pandemic; pediatric cache: cord-324764-w68y4fjw.txt plain text: cord-324764-w68y4fjw.txt item: #350 of 440 id: cord-324869-f14n0hk6 author: Khan, Hafiz Muhammad Waqas title: Unusual Early Recovery of a Critical COVID-19 Patient After Administration of Intravenous Vitamin C date: 2020-07-25 words: 2559 flesch: 44 summary: Based on the above data, vitamin C has been increasingly used recently in the treatment of COVID-19 disease, and Peng et al., from Wuhan University, initiated a phase II trial to study the efficacy of vitamin C infusion in the treatment of ARDS associated with SARS-CoV-2, in which patients receive 24 g of intravenous vitamin C per day for a total of 7 days Vitamin C infusion was not part of the treatment for COVID-19 at our institute as it has not been approved as a standard treatment for SARS-CoV-2. keywords: ards; covid-19; day; icu; patient; vitamin cache: cord-324869-f14n0hk6.txt plain text: cord-324869-f14n0hk6.txt item: #351 of 440 id: cord-325021-rv5fsitx author: Giacobbe, Daniele Roberto title: Bloodstream infections in critically ill patients with COVID‐19 date: 2020-06-14 words: 2702 flesch: 35 summary: Finally, although we apparently observed an improved survival of BSI in comparison with previous large studies conducted in non-COVID-19 ICU patients 7 , it should be reminded that our sample size of BSI patients was limited (n = 31) and that follow-up was very short. In this regard, a possible explanation may be the difficulty of diagnosing BSI in patients receiving anti-inflammatory drugs 21 , which prompted us to collect blood cultures in any case of worsening general conditions in COVID-19 patients, even in the absence of fever and increases in C-reactive protein serum levels. keywords: bsi; covid-19; icu; incidence; patients; risk; study cache: cord-325021-rv5fsitx.txt plain text: cord-325021-rv5fsitx.txt item: #352 of 440 id: cord-325201-yoy7kdli author: Timsit, Jean-François title: Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics date: 2015-03-26 words: 9133 flesch: 38 summary: Under this context, recent studies shed more light on the aminoglycoside PK/PD properties in ICU patients. Energy deficit in ICU patients is mainly caused by reduced intake due to under-prescribed calories and frequent feeding interruptions. keywords: candida; care; colonization; escalation; icu; infections; intensive; mortality; patients; pneumonia; sepsis; shock; study; therapy; treatment; use cache: cord-325201-yoy7kdli.txt plain text: cord-325201-yoy7kdli.txt item: #353 of 440 id: cord-325290-hbzbyqi4 author: Payne, Anna title: Redeployment of surgical trainees to intensive care during the COVID-19 pandemic: evaluation of the impact on training and wellbeing date: 2020-09-14 words: 2267 flesch: 44 summary: key: cord-325290-hbzbyqi4 authors: Payne, Anna; Rahman, Rafid; Bullingham, Roberta; Vamadeva, Sarita; Alfa-Wali, Maryam title: Redeployment of surgical trainees to intensive care during the COVID-19 pandemic: evaluation of the impact on training and wellbeing date: 2020-09-14 journal: J Surg Educ DOI: 10.1016/j.jsurg.2020.09.009 sha: doc_id: 325290 cord_uid: hbzbyqi4 OBJECTIVE: : The aim of this study was to evaluate the impact of redeployment of surgical trainees to intensive care units (ICUs) during the COVID-19 pandemic- in terms of transferrable technical and non-technical skills and wellbeing. SETTING: : The study involved surgical trainees that had been redeployed to the (ICU) across all hospitals in London during the COVID-19 pandemic. keywords: care; covid-19; pandemic; redeployment; skills; trainees cache: cord-325290-hbzbyqi4.txt plain text: cord-325290-hbzbyqi4.txt item: #354 of 440 id: cord-325599-2gutb4m1 author: Lapidus, Nathanael title: Biased and unbiased estimation of the average length of stay in intensive care units in the Covid-19 pandemic date: 2020-10-16 words: 4401 flesch: 45 summary: For example, one may think about the impact of disease knowledge on triage decisions and on the decision to withdraw early mechanical ventilation based on refinement of prognostic factors (ethical issues), bed availability and pressure of this threatening epidemic on the organization of the healthcare system likely modifies the characteristics of admitted patients as well as various specific characteristics of the units (including cultural behaviors), accumulating experience with COVID-19 patients likely improves management procedures according to time. Third and to conclude, whenever the estimates reported in this study would be generalizable to other settings, then this is bad news: long ICU LOS as reported here imply that occupied beds remain unavailable for a long time and this adds additional pressure to the surge in ICU beds encountered in many places worldwide. keywords: covid-19; date; days; estimates; icu; los; patients; study cache: cord-325599-2gutb4m1.txt plain text: cord-325599-2gutb4m1.txt item: #355 of 440 id: cord-325649-zzhsrytw author: Rispoli, Rossella title: Spine surgery in Italy in the COVID-19 era: Proposal for assessing and responding to the regional state of emergency date: 2020-08-07 words: 2783 flesch: 44 summary: The alert level data points relative to the FVG Region of northeast Italy are shown in white points in The proposal for prioritizing surgical activities in relation to health care system alert levels is given in All these patients were admitted urgently due to the onset with neurological deficits and, in one case, for early signs of infection. By the time of the World Health Organization (WHO) classification of the novel coronavirus as a global pandemic (1) , many hospitals in northern Italy were already overcrowded by COVID-19 patients, especially intensive care units, where about 50% of all available ICU beds were occupied by COVID-19 patients ( 2 ) . keywords: care; covid-19; health; patients; spine; surgery; system cache: cord-325649-zzhsrytw.txt plain text: cord-325649-zzhsrytw.txt item: #356 of 440 id: cord-325664-9ool5z9s author: Immovilli, Paolo title: COVID-19 mortality and ICU admission: the Italian experience date: 2020-05-15 words: 376 flesch: 40 summary: These preliminary data evidence the pivotal preventive role played by early lockdown measures to reduce outbreak magnitude and place less pressure on ICU beds availability; however, these data should be interpreted with caution because of possible bias: patients could be allowed outside the ICU due to various reasons (i.e., age, comorbidities, frailty index), as it occurs in daily clinical practice. However, examining the differing outbreak magnitudes in regions with different ICU availability evidenced a discrepancy in the percentage of ICU-admitted patients. keywords: icu; mortality cache: cord-325664-9ool5z9s.txt plain text: cord-325664-9ool5z9s.txt item: #357 of 440 id: cord-325700-f102uk2m author: Fraser, Douglas D. title: Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers date: 2020-10-21 words: 5712 flesch: 33 summary: Although plasma kynurenine effectively discriminated COVID19+ patients from healthy control subjects, determination of COVID19 status in ICU patients required further specificity that was optimally provided by an arginine/kynurenine ratio. None. MEASUREMENTS AND MAIN RESULTS: Age- and sex-matched healthy controls and ICU patients that were either coronavirus disease 2019 positive or coronavirus disease 2019 negative were enrolled. keywords: arginine; control; coronavirus; coronavirus disease; covid19; creatinine; disease; icu; kynurenine; metabolites; patients; ratio; subjects cache: cord-325700-f102uk2m.txt plain text: cord-325700-f102uk2m.txt item: #358 of 440 id: cord-325941-1sogg526 author: Komaru, Yohei title: Urinary Neutrophil Gelatinase-Associated Lipocalin in Critically Ill Patients With Coronavirus Disease 2019 date: 2020-08-20 words: 1481 flesch: 43 summary: The area under the receiver operating characteristic curve for AKI diagnosis by urinary NGAL level at ICU admission was 0.84 (95% CI, 0.56-0.96). In this study involving 17 critically ill COVID-19 patients, we found that urinary NGAL level at ICU admission was elevated in patients who went on to develop AKI during their ICU stay. keywords: icu; ngal; patients; urinary cache: cord-325941-1sogg526.txt plain text: cord-325941-1sogg526.txt item: #359 of 440 id: cord-326272-ya3r0h1t author: Dobesh, Paul P. title: Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID‐19 date: 2020-10-01 words: 8611 flesch: 41 summary: All rights reserved There have also been observational trials that have compared rates of VTE in COVID-19 patients to historical controls without COVID-19 (Table 3) . The rate of PE was 3-fold higher in COVID-19 patients compared to those without, but was also more than 2-fold higher than influenza patients specifically during the same time frame. keywords: anticoagulation; article; coronavirus; covid-19; dimer; disease; icu; patients; prophylaxis; risk; sars; thrombosis; venous; vte cache: cord-326272-ya3r0h1t.txt plain text: cord-326272-ya3r0h1t.txt item: #360 of 440 id: cord-326315-ncfxlnpj author: Cillóniz, Catia title: Community-acquired polymicrobial pneumonia in the intensive care unit: aetiology and prognosis date: 2011-09-14 words: 4179 flesch: 26 summary: The clinical significance of polymicrobial aetiology in CAP patients admitted to the ICU has not been specifically addressed. The frequency and clinical significance of polymicrobial aetiology in community-acquired pneumonia (CAP) patients admitted to the ICU have been poorly studied. keywords: aetiology; cap; disease; hospital; patients; pneumonia; polymicrobial; treatment; viruses cache: cord-326315-ncfxlnpj.txt plain text: cord-326315-ncfxlnpj.txt item: #361 of 440 id: cord-326532-2ehuuvnx author: Götzinger, Florian title: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study date: 2020-06-25 words: 5330 flesch: 40 summary: The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Clinical characteristics of a case series of children with coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review SARS-CoV-2 infection in children Epidemiology of COVID-19 among children in China Detection of Covid-19 in children in early Spread of SARS-CoV-2 in the Icelandic population CDC COVID-19 Response Team. The study was conducted in accordance with the Declaration of Helsinki and its subsequent Evidence before this study We searched MEDLINE on May 7, 2020, through the PubMed interface to identify publications describing clinical studies in children with COVID-19. keywords: children; cov-2; covid-19; data; disease; icu; individuals; infection; patients; sars; study; support cache: cord-326532-2ehuuvnx.txt plain text: cord-326532-2ehuuvnx.txt item: #362 of 440 id: cord-326644-5war06j2 author: Supino, M. title: World governments should protect their population from COVID-19 pandemic using Italy and Lombardy as precursor date: 2020-03-27 words: 2803 flesch: 54 summary: After ten days from the first ICU patient (February, 20 th 2020), the number of COVID-19 ICU patients was All rights reserved. preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in While NHS are prepared to receive a certain number of ICU patients distributed during the influenza season, which lasts several months, no NHS can manage an exponentially growing number of COVID-19 patients. keywords: covid-19; icu; italy; lockdown; preprint cache: cord-326644-5war06j2.txt plain text: cord-326644-5war06j2.txt item: #363 of 440 id: cord-326708-92lsnv4g author: Craig, J. title: Estimating critical care capacity needs and gaps in Africa during the COVID-19 pandemic date: 2020-06-04 words: 3532 flesch: 36 summary: Due to lack of data on current national capacities, gaps in hospital bed capacity at outbreak peak were not calculated for two countries (Eswatini and South Sudan), for ICU bed capacity for four countries (Benin, Equatorial Guinea, Madagascar, and Mozambique), and gaps in ventilator capacity were not calculated for six countries (Benin, Republic of the Congo, Eritrea, Malawi, Mauritius, and the Seychelles). The average number of ICU beds needed at outbreak peak across the 52 included countries ranged from 2 per 100,000 people (SD: 0.1) when 30% of people with severe COVID-19 infections access health services to 6.5 per 100,000 (SD: 0.5) assuming 100% of people seek out health services. keywords: beds; countries; covid-19; health; peak; services cache: cord-326708-92lsnv4g.txt plain text: cord-326708-92lsnv4g.txt item: #364 of 440 id: cord-326989-l8nfd03a author: Cammarota, Gianmaria title: Critical Care Surge Capacity to Respond to the COVID-19 Pandemic in Italy: A Rapid and Affordable Solution in the Novara Hospital date: 2020-05-19 words: 1312 flesch: 35 summary: However, being that the operating rooms converted into COVID-19 ICU stations, which were dispersed in different locations distant from the supervision of the control unit, the ICU staff had significant difficulties to work as one team and to ensure the same level of care. By addressing the key elements of health care system surge capacity from contingency to crisis, a prompt response to the sudden request of IMV was provided, converting the general ICU into a COVID-19 unit and increasing the number of COVID-19 ICU beds by 107%. keywords: care; covid-19; icu; unit cache: cord-326989-l8nfd03a.txt plain text: cord-326989-l8nfd03a.txt item: #365 of 440 id: cord-327032-4bet4e8l author: Khan, S. H. title: Delirium Incidence, Duration and Severity in Critically Ill Patients with COVID-19 date: 2020-06-01 words: 3705 flesch: 40 summary: 26, 27 Our study findings represent a significant departure from recently reported trends in rates of ICU delirium, including rates of mechanical ventilation (36%), delirium (22.7%), and coma (24.0%) at our own center during the influenza pandemic occurring in 2009-2010 (see Supplementary Table 2 ). Reductions in the prevalence of ICU delirium from a historical high of 80% to rates of 16.5-33% have been reported over the past two years. keywords: cam; covid-19; delirium; icu; license; patients; preprint cache: cord-327032-4bet4e8l.txt plain text: cord-327032-4bet4e8l.txt item: #366 of 440 id: cord-327452-fl7yrpzs author: Sayde, George title: Implementing an intensive care unit (ICU) diary program at a Large Academic Medical Center: Results from a randomized control trial evaluating psychological morbidity associated with critical illness date: 2020-07-02 words: 4737 flesch: 41 summary: ICU diaries are an intervention increasingly under study with potential to mitigate ICU-related psychological morbidity, including ICU-related post-traumatic stress disorder (PTSD), depression and anxiety. CONCLUSIONS: Results from psychometric testing demonstrate no benefit of ICU diaries versus bedside education-alone in reducing PTSD symptoms related to the intensive care stay. keywords: care; diaries; diary; icu; patients; study; symptoms cache: cord-327452-fl7yrpzs.txt plain text: cord-327452-fl7yrpzs.txt item: #367 of 440 id: cord-328948-m5h2hgpb author: Wang, Hanyin title: Patient Care Rounds in the Intensive Care Unit During COVID-19 date: 2020-07-04 words: 636 flesch: 55 summary: A creative solution for ICU rounds is needed in the COVID-19 era. 4, 5 Our hospital recently implemented a telemedicine model for ICU rounds that is well perceived by the ICU team and patient families. keywords: care; icu; rounds cache: cord-328948-m5h2hgpb.txt plain text: cord-328948-m5h2hgpb.txt item: #368 of 440 id: cord-329098-vefgi5h6 author: BANI-SADR, Firouzé title: Corticosteroid therapy for patients with CoVID-19 pneumonia: a before-after study date: 2020-07-04 words: 1866 flesch: 35 summary: In this before-and-after study of 319 hospitalized CoVID-19 patients, after adjustment for age, National Early Warning score and institutionalization status, the after period (n=172) -during which corticosteroids were routinely recommended for patients presenting with CoVID-19 pneumonia at our institution-was associated with a lower risk of death (HR =0.47; 95% CI 0.23 -0.97; p=0.04), and a lower risk of ICU admission and/or death before ICU admission (HR =0.37 95% CI 0.21 -0.64; p=0.0005). Another limitation of our study is that CoVID-19 pneumonia diagnosis was more often performed by chest CT scan in patients who received corticosteroids group than in patients who did not. keywords: admission; covid-19; icu; patients; period cache: cord-329098-vefgi5h6.txt plain text: cord-329098-vefgi5h6.txt item: #369 of 440 id: cord-329713-dqmvpqtd author: Pasin, Laura title: Regional COVID-19 Network for Coordination of SARS-CoV-2 outbreak in Veneto, Italy date: 2020-05-15 words: 1820 flesch: 37 summary: (B) Number of coronavirus-2019 patients in Patients discharged from the intensive care unit alive (dashed green line) are distinct from patients who died in the intensive care unit Dark red bars, intensive care unit beds occupied by non-coronavirus-2019 patients None. In the following weeks, however, the number of patients requiring ICU admission exceeded the number of deaths or discharged patients (Fig 3) . keywords: care; covid-19; icu; number; patients cache: cord-329713-dqmvpqtd.txt plain text: cord-329713-dqmvpqtd.txt item: #370 of 440 id: cord-329727-h47q76y8 author: Sisó-Almirall, Antoni title: Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona date: 2020-08-21 words: 3445 flesch: 48 summary: This study summarizes the clinical, biological and radiological characteristics, evolution and prognostic factors of patients with COVID-19 disease in primary and community healthcare. A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Clinical Characteristics of Covid-19 in New York City Utility of hyposmia and hypogeusia for the diagnosis of COVID-19 COVID-19)-United States The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia keywords: 95%ci; admission; covid-19; death; icu; patients cache: cord-329727-h47q76y8.txt plain text: cord-329727-h47q76y8.txt item: #371 of 440 id: cord-329996-f2hxpat3 author: Wahlster, Sarah title: The COVID-19 Pandemic’s Impact on Critical Care Resources and Providers: A Global Survey date: 2020-09-11 words: 3839 flesch: 46 summary: The high prevalence of provider burnout, and its association with reported insufficient resources and poor communication from supervisors suggest a need for targeted interventions to support HCPs on the front lines. Limiting MV for COVID-19 patients was reported by 16% of respondents, was lowest in North America (10%), and was associated with reduced ventilator availability (aRR:2.10, 95% CI:1.61-2.74). keywords: burnout; care; covid-19; hcps; icu; patients; respondents cache: cord-329996-f2hxpat3.txt plain text: cord-329996-f2hxpat3.txt item: #372 of 440 id: cord-331369-q7opbz7v author: Alharthy, Abdulrahman title: Configuring a hospital in the COVID-19 era by integrating crisis management logistics date: 2020-07-23 words: 929 flesch: 46 summary: We have utilized daily COVID-19 training sessions to provide additional emotional reassurance (ie, dual training and emotional support strategy). The refinement of the respiratory and ICU care included changing the ventilator circuits and filters based on patient needs, avoiding nebulizers, creating specialized intubation and prone-positioning ventilation teams, and upgrading the oxygen supply system. keywords: care; cmt; covid-19; icu cache: cord-331369-q7opbz7v.txt plain text: cord-331369-q7opbz7v.txt item: #373 of 440 id: cord-331481-zeaqi1uc author: Al-Ani, Fatimah title: Thrombosis risk associated with COVID-19 infection. A scoping review date: 2020-05-27 words: 4642 flesch: 38 summary: We conducted a scoping review using a single engine search for studies assessing thrombosis and coagulopathy in COVID-19 patients. In case reports of COVID-19 patients, PE was identified in patients with no VTE risk factors 28 . keywords: covid-19; disease; patients; risk; studies; study; survivors; thrombosis cache: cord-331481-zeaqi1uc.txt plain text: cord-331481-zeaqi1uc.txt item: #374 of 440 id: cord-331500-l3hkn2li author: Luyt, Charles-Edouard title: Pulmonary infections complicating ARDS date: 2020-11-11 words: 7549 flesch: 20 summary: However, some preventive measures deserve a special focus in the context of ARDS patients (Fig. 6) : (1) oral care with chlorhexidine is suspected to worsen respiratory failure; (2) selective digestive decontamination (SDD) deserves to be discussed in such high-risk patients, as it has been proven to be effective in reducing mortality in ICU patients and likely lowers VAP rates. Acute respiratory distress syndrome Changes in prevalence of health care-associated infections in US Hospitals Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy Ventilator-associated pneumonia in ARDS patients: the impact of prone positioning. keywords: acute; ards; care; ecmo; icu; infection; lung; patients; pneumonia; pulmonary; risk; syndrome; trial; vap; ventilator cache: cord-331500-l3hkn2li.txt plain text: cord-331500-l3hkn2li.txt item: #375 of 440 id: cord-332074-s824m91f author: Caillet, Anaëlle title: Psychological Impact of COVID-19 on ICU Caregivers date: 2020-09-29 words: 2456 flesch: 56 summary: -The COVID-19 impact study was carried out exclusively in Lyon in the same hospital. Moreover, the daily lives of ICU caregivers have been rapidly disrupted. keywords: anxiety; caregivers; covid-19; icu; risk; study cache: cord-332074-s824m91f.txt plain text: cord-332074-s824m91f.txt item: #376 of 440 id: cord-332180-dw4h69tp author: Cheng, Fu-Yuan title: Using Machine Learning to Predict ICU Transfer in Hospitalized COVID-19 Patients date: 2020-06-01 words: 4130 flesch: 39 summary: The non-ICU bed to ICU transfer rate in our cohort was 3.7 percent, which created an extreme class imbalance between the majority class (feature vectors without the occurrence of ICU transfer within 24 h) and the minority class (feature vectors with ICU transfer within 24 h). Low sample size and class imbalance resulting from low ICU transfer rates are major limitations to this version of the model, which resulted in low precision. keywords: care; cohort; covid-19; data; icu; model; patients; risk; transfer; variables cache: cord-332180-dw4h69tp.txt plain text: cord-332180-dw4h69tp.txt item: #377 of 440 id: cord-332979-eln7n6zb author: Ciminelli, G. title: How Emergency Care Congestion Increases Covid-19 Mortality: Evidence from Lombardy, Italy date: 2020-10-29 words: 5198 flesch: 52 summary: How can we explain the result that Covid-19 mortality rates are higher in communities that are more distant from the intensive care? We find that Covid-19 mortality is up to 60% higher in the average municipality -- which is 15 minutes driving away from the closest ICU -- than in a municipality with an ICU in town. keywords: 2020; covid-19; emergency; icu; license; medrxiv; mortality; preprint cache: cord-332979-eln7n6zb.txt plain text: cord-332979-eln7n6zb.txt item: #378 of 440 id: cord-333146-d55kybmz author: Sedes, P. Rascado title: Contingency Plan for the Intensive Care Services for the COVID-19 pandemic date: 2020-05-14 words: 3085 flesch: 55 summary: The role of the intensive care specialist on the committees is essential to: • Prepare pathways and areas for critical patient care. • Conduct a census of nursing staff with knowledge and experience in critical patient care. keywords: care; covid-19; following; hospital; icu; pandemic; patients; plan; transfer cache: cord-333146-d55kybmz.txt plain text: cord-333146-d55kybmz.txt item: #379 of 440 id: cord-334367-w96iqo6q author: Devlin, John W. title: Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults With Coronavirus Disease 2019 date: 2020-06-12 words: 4229 flesch: 28 summary: Although multiple studies demonstrate the salutary impact of Bundle use on ICU patient care, outcomes, and healthcare costs in non-COVID-19 patients (21) (22) (23) (24) , important COVID-19-related issues and barriers may preclude the routine use of the Bundle in this population, particularly at centers experiencing a surge of critically ill adults with COVID-19. Society of Critical Care Medicine and the American Society for Parenteral and Enteral Nutrition Incidence of propofol-related infusion syndrome in critically ill adults: A prospective, multicenter study Early neuromuscular blockade in the acute respiratory distress syndrome Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient Demand for Ventilator Drugs 'Unprecedented Repurposing valproate, enteral clonidine, and phenobarbital for comfort in adult ICU patients: A literature review with practical considerations The Medical Letter on Drugs and Therapeutics: Some Drugs for COVID-19. keywords: adults; bundle; care; covid-19; critical; delirium; icu; pain; patients; sedation; strategies; use cache: cord-334367-w96iqo6q.txt plain text: cord-334367-w96iqo6q.txt item: #380 of 440 id: cord-334834-qg23x2pw author: Marshall, Andrea P. title: A critical care pandemic staffing framework in Australia date: 2020-10-08 words: 5780 flesch: 37 summary: Expanding the critical care workforce may be achieved through deployment of existing staff with critical care experience from noncritical care to critical care areas. Within health services, early identification of these staff members with critical care experience would be helpful, keeping in mind that deployment to the ICU will need to be mutually agreeable [15] . keywords: care; covid-19; health; icu; intensive; pandemic; patient; recommendations; staff; staffing; support; workforce cache: cord-334834-qg23x2pw.txt plain text: cord-334834-qg23x2pw.txt item: #381 of 440 id: cord-335033-cwhm7v0s author: Vergano, Marco title: Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic date: 2020-04-22 words: 1550 flesch: 36 summary: In the worst-case scenario of complete saturation of ICU resources, a first come, first served criterion is not recommended, as it would ultimately result in denying access to ICU care to a large number of potentially curable patients. Moreover, the patients who are affected by the application of new, more stringent criteria of eligibility for ICU admission (and/or their proxies) should be Allocation of ICU resources is a complex and delicate task. keywords: admission; care; icu; patients cache: cord-335033-cwhm7v0s.txt plain text: cord-335033-cwhm7v0s.txt item: #382 of 440 id: cord-335351-8hdok02n author: Hashmi, Muhammad Daniyal title: Assessing the need for transfer to the intensive care unit for Coronavirus-19 disease: Epidemiology and risk factors date: 2020-10-27 words: 3792 flesch: 52 summary: Co-morbid illnesses are not associated with the risk for ICU transfer while two initial lab values (ALC <0.8 10 3 /ml and ferritin >1000 ng/mL ) identify those at higher risk for ICU admission. Neither baseline clinical factors nor the CURB-65 score perform well as screening tests to categorize these subjects as likely to progress to ICU care. keywords: care; covid-19; icu; need; patients; risk; score; transfer cache: cord-335351-8hdok02n.txt plain text: cord-335351-8hdok02n.txt item: #383 of 440 id: cord-335802-1kiqfy68 author: Azoulay, Elie title: Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset date: 2020-08-11 words: 3519 flesch: 43 summary: In the earliest descriptions of COVID-19 patients hospitalised in Wuhan, China, time from viral symptom onset to dyspnoea was 5 days and time to hospital admission was 7 days Interventions that are currently used in COVID-19 patients might impact different clinical endpoints according to time since viral symptom onset. keywords: admission; covid-19; icu; mortality; onset; patients; symptom; time cache: cord-335802-1kiqfy68.txt plain text: cord-335802-1kiqfy68.txt item: #384 of 440 id: cord-335894-6m0nnufu author: Ceriello, Antonio title: Issues for the management of people with diabetes and COVID-19 in ICU date: 2020-07-20 words: 4150 flesch: 38 summary: The measurement of D-dimer is very useful in the prediction of the risk for a thrombotic event and its evaluation has been suggested regarding the management of COVID-19 patients [55, 56] . The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study Coagulation activation in diabetes mellitus: the role of hyperglycaemia and therapeutic prospects Hyperglycemia-induced thrombin formation in diabetes The possible role of oxidative stress Low molecular weight heparin restores antithrombin III activity from hyperglycemia induced alterations Incremental role of glycaemic variability over HbA1c in identifying type 2 diabetic patients with high platelet reactivity undergoing percutaneous coronary intervention Inflammageing and metaflammation: the yin and yang of type 2 diabetes Acute hyperglycaemia: a 'new' risk factor during myocardial infarction Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients Scientific Document Group: 2019 ESC guidelines on diabetes, prediabetes, and cardiovascular diseases developed in collaboration with the EASD Considerations for statin therapy in patients with COVID-19 Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications Effect of pravastatin on the frequency of ventilator-associated pneumonia and on intensive care unit mortality: open-label, randomized study Association of elevated plasma interleukin-18 level with increased mortality in a clinical trial of statin treatment for acute respiratory distress syndrome Type 1 diabetes and cardiovascular disease Higher glucose variability in type 1 than in type 2 diabetes patients admitted to the intensive care unit: a retrospective cohort study Searching the reason of a lower aggressiveness of the CoronaVirus disease in Type 1 Diabetes COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options Diabetes and Cardiovascular Disease (D&CVD) EASD Study Group, et al. keywords: covid-19; diabetes; disease; glucose; icu; patients; people; risk; type cache: cord-335894-6m0nnufu.txt plain text: cord-335894-6m0nnufu.txt item: #385 of 440 id: cord-335927-sbou89vg author: González-Calle, David title: Coronavirus Disease 2019 Intermediate Care Units: Containing Escalation of ICUs date: 2020-08-25 words: 784 flesch: 41 summary: To deal with the shortness of ICUs capacity effectively, our regional healthcare system further put in place COVID-19 IMCUs infrastructures consisting of a 24-hour healthcare multidisciplinary team with capacity to perform noninvasive mechanical ventilation in monitored beds (4) . This COVID-19 IMCUs were implemented with two major objectives: 1) avoiding overwhelmed of ICUs, concentrating and taking care of candidate patients to ICU and 2) favoring and incrementing step-down from the ICUs. keywords: icu; patients cache: cord-335927-sbou89vg.txt plain text: cord-335927-sbou89vg.txt item: #386 of 440 id: cord-335975-m6lkrehi author: None title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: 89523 flesch: 50 summary: The aim of this study was to compare the outcome of ICU patients having received carbapenems to those having received a carbapenem-sparing agent (CSA). Conclusion: Severe hypoxemia, independently from ARDS, worsens the prognosis of ICU patients. keywords: acute; admission; age; aim; analysis; antibiotic; ards patients; blood; brain; cardiac; care; cases; characteristics; children; clinical; conclusion; criteria; data; days; death; diagnosis; disease; drug; duration; factors; failure; fig; group; high; hospital; icu; icu admission; icu mortality; icu patients; impact; incidence; increase; infection; intensive; introduction; intubation; january; length; level; low; management; mean; median; medical; methods; min; mortality; n =; niv; non; outcome; p =; patients; period; pneumonia; post; pressure; prognosis; rate; respiratory; results; resuscitation; risk; score; sepsis; septic; severity; shock; shock patients; stay; studies; study; study period; therapy; time; treatment; unit; use; vap; ventilation; volume; vs.; years cache: cord-335975-m6lkrehi.txt plain text: cord-335975-m6lkrehi.txt item: #387 of 440 id: cord-335977-f00758o2 author: Martin-Loeches, I. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 words: 4307 flesch: 35 summary: key: cord-335977-f00758o2 authors: Martin-Loeches, I.; Lisboa, T.; Rhodes, A.; Moreno, R. P.; Silva, E.; Sprung, C.; Chiche, J. D.; Barahona, D.; Villabon, M.; Balasini, C.; Pearse, R. M.; Matos, R.; Rello, J. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 journal: Intensive Care Med DOI: 10.1007/s00134-010-2078-z sha: doc_id: 335977 cord_uid: f00758o2 INTRODUCTION: The main objective of this study is therefore to assess the effect on survival of early corticosteroid therapy compared with those who did not receive corticosteroids or received them subsequently as rescue therapy, in a cohort of patients hospitalized with severe presentation of pandemic (H1N1)v influenza A infection in the ICU. keywords: acute; admission; corticosteroid; hospital; icu; infection; influenza; pandemic; patients; pneumonia; therapy; use cache: cord-335977-f00758o2.txt plain text: cord-335977-f00758o2.txt item: #388 of 440 id: cord-336395-v157jzvv author: Battaglini, Denise title: Chest physiotherapy: an important adjuvant in critically ill mechanically ventilated patients with COVID-19 date: 2020-08-17 words: 7012 flesch: 29 summary: Recent manuscripts on respiratory physiotherapy in COVID-19 patients provided general recommendations but did not focus on critically ill COVID-19 cases (Lazzeri et al., 2020; Thomas et al., 2020) . Sputum production was reported in about 34% of COVID-19 patients (Guan et al., 2020) , thus suggesting that, by promoting mucus clearance during mechanical ventilation, early physiotherapy interventions (such as subglottic secretion drainage, postural hygiene, and ventilator hyperinflation) may produce beneficial effects in this new critically ill population (Thomas et al., 2020) . keywords: chest; covid-19; et al; extubation; icu; lung; patients; physiotherapy; position; pressure; risk; thomas; ventilator cache: cord-336395-v157jzvv.txt plain text: cord-336395-v157jzvv.txt item: #389 of 440 id: cord-336973-z8mwzmf6 author: Rubulotta, Francesca title: In Response date: 2020-07-14 words: 1184 flesch: 43 summary: key: cord-336973-z8mwzmf6 authors: Rubulotta, Francesca; Soliman-Aboumarie, Hatem; Filbey, Kevin; Geldner, Goetz; Kuck, Kai; Ganau, Mario; Hemmerling, Thomas M. title: In Response date: 2020-07-14 journal: Anesth Analg DOI: 10.1213/ane.0000000000005121 sha: doc_id: 336973 cord_uid: z8mwzmf6 nan In Response W e thank esteemed colleagues Drs Brull and Kopman, 1 both well-known experts in the field of neuromuscular monitoring and blockade for their interest in our article and their comments. The creation of dedicated anesthesia intubation teams during the COVID-19 crisis as well as the increasing engagement of anesthesiologists in the ICU setting led us to believe that presenting basic principles of neuromuscular monitoring could be of interest for all readers. keywords: covid-19; icu; monitoring; patients cache: cord-336973-z8mwzmf6.txt plain text: cord-336973-z8mwzmf6.txt item: #390 of 440 id: cord-337499-jzpgtkai author: Yong Choi, Sung title: Safe surgical tracheostomy during the COVID-19 pandemic: A protocol based on experiences with Middle East Respiratory Syndrome and COVID-19 outbreaks in South Korea date: 2020-06-17 words: 4737 flesch: 43 summary: Several studies related to guidelines or recommendations on surgical tracheostomy for COVID-19 patients have been published. Thus, we did not use a stay suture or Björk flap during surgical tracheostomy in MERS and COVID-19 patients. keywords: covid-19; icu; mers; outbreak; patients; ppe; protocol; tracheostomy; transmission cache: cord-337499-jzpgtkai.txt plain text: cord-337499-jzpgtkai.txt item: #391 of 440 id: cord-337705-snwktcz5 author: Bansal, Agam title: The Association of D-dimers with Mortality, Intensive Care Unit admission or Acute Respiratory Distress Syndrome in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-analysis date: 2020-09-18 words: 1562 flesch: 43 summary: This was likely due to differences in study size, selection bias, and different stages at which the D-dimer values were measured. key: cord-337705-snwktcz5 authors: Bansal, Agam; Singh, Achintya D.; Jain, Vardhmaan; Aggarwal, Manik; Gupta, Samiksha; Padappayil, Rana Prathap; Nadeem, Mahum; Joshi, Sonya; Mian, Agrima; Greathouse, Tyler; Wells, David; Gupta, Mohak; Khan, Muhammad Zarrar title: The Association of D-dimers with Mortality, Intensive Care Unit admission or Acute Respiratory Distress Syndrome in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-analysis date: 2020-09-18 journal: keywords: dimer; patients; studies cache: cord-337705-snwktcz5.txt plain text: cord-337705-snwktcz5.txt item: #392 of 440 id: cord-337917-vvvo5t4h author: Tempe, Dr. Deepak K. title: Challenges in Preparing and managing the critical care services for a large urban area during COVID-19 outbreak: Perspective from Delhi date: 2020-05-26 words: 3395 flesch: 57 summary: In Delhi, there is a perpetual shortage of ICU beds, therefore, the biggest challenge was to create sufficient ICU beds for an anticipated surge of Covid-19 patients during the next few weeks. The main challenges faced among others were, estimating the number of ICU beds to be created; deciding the dedicated Covid hospitals; procurement of ventilators, personal protection equipment and other related material; mobilizing the human resource and their training; and providing isolated in-house accommodation to the staff on duty. keywords: beds; care; covid-19; delhi; hospitals; icu; patients cache: cord-337917-vvvo5t4h.txt plain text: cord-337917-vvvo5t4h.txt item: #393 of 440 id: cord-338403-mfde6juv author: Li, Bo title: Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China date: 2020-03-11 words: 3441 flesch: 47 summary: According to Summary of the 2018 report on cardiovascular diseases in China, the morbidities of the hypertension and diabetes were, respectively, 23.2% and 10.9%, and there were about 13 million of cerebrovascular disease patients and 11 million of cardiovascular patients [21] . We then compared the difference of the prevalence of the three diseases between severe patients and non-severe patients (or ICU patients vs non-ICU patients according to the data in the studies). keywords: cardiac; diseases; icu; injury; non; patients; studies cache: cord-338403-mfde6juv.txt plain text: cord-338403-mfde6juv.txt item: #394 of 440 id: cord-338531-hsh9425f author: Harris, Gavin H. title: Design for Implementation of a System-Level ICU Pandemic Surge Staffing Plan date: 2020-06-15 words: 3931 flesch: 36 summary: As a result of this, as well as the fact that ICU provider staffing throughout the United States currently operate at or near capacity, the risk for severe and augmented disruption in delivery of care is very real. This space plan allowed our team to guide each hospital leadership team through the process of generating a plan for ICU provider staffing using the above model. keywords: capacity; care; icu; patients; providers; staffing; surge; system; tier cache: cord-338531-hsh9425f.txt plain text: cord-338531-hsh9425f.txt item: #395 of 440 id: cord-339015-qn8wbnlw author: Kayingo, Gerald title: Bacteria and Viruses: The Bogeymen in the Intensive Care Unit date: 2019-03-06 words: 2381 flesch: 29 summary: P. aeruginosa is one of the leading causes of morbidity in ICU patients, especially those with VAP. It is also a common cause of ICU infections associated with devices and catheters, infections in the urinary tract, and surgical site infections. keywords: icu; infections; organisms; patients; sepsis; species; therapy cache: cord-339015-qn8wbnlw.txt plain text: cord-339015-qn8wbnlw.txt item: #396 of 440 id: cord-339021-mhdaov1f author: Hong, Kyung Soo title: Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study date: 2020-05-01 words: 2197 flesch: 49 summary: Levels of all proinflammatory cytokines were significantly higher in ICU patients. In our study, diabetes mellitus tended to be more common in ICU patients (23.1% vs. 7.1%, p=0.096). keywords: acute; care; clinical; icu; patients; study cache: cord-339021-mhdaov1f.txt plain text: cord-339021-mhdaov1f.txt item: #397 of 440 id: cord-339478-v7by6dnp author: Kessler, Remi A. title: Changes in Neurosurgery Resident Education During the COVID-19 Pandemic: An Institutional Experience from a Global Epicenter date: 2020-05-08 words: 1112 flesch: 45 summary: One of the first changes made was expanded resident coverage to staffing this older neurosurgical ICU and junior residents responsible for call every third night. 4 A number of programs have reported reducing resident staffing by 50% with teams rotating one week at a time, while the rest of the residents remain at home. keywords: covid-19; icu; neurosurgery; resident cache: cord-339478-v7by6dnp.txt plain text: cord-339478-v7by6dnp.txt item: #398 of 440 id: cord-339670-lq46nj8j author: Takahashi, Nozomi title: Clinical course of a critically ill patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-06-16 words: 1752 flesch: 40 summary: Upon ICU admission (day 10 from admission, ICU day 1), atelectasis in the dorsal side of the lung was noted in the chest CT (Fig. 1b , Supplemental Figure E2 and E3), while no apparent purulent sputum was observed by bronchoscopy, and presented no evidence of bacterial infection in the gram stain and culture. Interferon beta-1b subcutaneous injection was initiated immediately to enhance anti-viral therapy, and favipiravir on ICU day 10 upon availability. keywords: day; ecmo; icu; organ; sars cache: cord-339670-lq46nj8j.txt plain text: cord-339670-lq46nj8j.txt item: #399 of 440 id: cord-339695-3ij5pjjy author: Nopp, Stephan title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis date: 2020-09-25 words: 4717 flesch: 36 summary: All rights reserved Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography Venous Thromboembolism in Critically Ill Patients with Covid-19: Results of a Screening Study for Deep Vein Thrombosis Clinical Characteristics of Covid-19 in Remdesivir for the Treatment of Covid-19 -Preliminary Report Impact of anticoagulation prior to COVID-19 infection: a propensity score-matched cohort study Anakinra for severe forms of COVID-19: a cohort study Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 ( Therefore, the true underlying burden of VTE in COVID-19 patients is still not fully understood. keywords: analysis; covid-19; data; icu; patients; rates; risk; studies; study; vte cache: cord-339695-3ij5pjjy.txt plain text: cord-339695-3ij5pjjy.txt item: #400 of 440 id: cord-340069-v7yrc0q5 author: Al Maani, Amal title: Ongoing Challenges with Healthcare-Associated Candida auris Outbreaks in Oman date: 2019-10-23 words: 4502 flesch: 43 summary: Candida auris: A Review of the Literature Candida auris-The growing menace to global health Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses Increasing prevalence, molecular characterization and antifungal drug susceptibility of serial Candida auris isolates in Kuwait Epidemiologic shift in candidemia driven by Candida auris First report of Candida auris in America: Clinical and microbiological aspects of 18 episodes of candidemia Multidrug-resistant Candida haemulonii and C. auris First report of Candida auris in Oman: Clinical and microbiological description of five candidemia cases Candida auris otomycosis in Iran and review of recent literature Candida auris was isolated by routine microbiology procedures from clinical samples, such as blood, urine, surgical wounds, and catheters, as well as from screening samples (axilla, groin, nasal, throat, and perianal swabs). keywords: auris; candida; care; cases; clinical; icu; infection; isolates; outbreak; patients; positive cache: cord-340069-v7yrc0q5.txt plain text: cord-340069-v7yrc0q5.txt item: #401 of 440 id: cord-341063-3rqnu5bu author: None title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 words: 98736 flesch: 48 summary: Since altered liver function has also been described in ICU patients without sepsis [1, 2] , the influence of sepsis may be overestimated. The aim of this work is to analyze the connection between serum and fecal levels of AMM in ICU patients. keywords: acute; admission; adult patients; age; aim; aki; analysis; ards; arrest; assessment; baseline; blood; brain; cardiac; care; care patients; care unit; cases; changes; clinical; cohort; complications; conclusions; control; correlation; criteria; critical; data; day mortality; days; decrease; diagnosis; difference; discharge; duration; dysfunction; early; effect; emergency; end; factors; failure; fig; flow; fluid; following; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increase; infection; injury; introduction; length; levels; lung; mean; median; medical; methods; min; model; months; mortality; non; organ; outcome; p<0.001; parameters; patients; period; population; post; pressure; protocol; rate; renal; results; risk; risk patients; score; sepsis; septic; severity; shock; significant; sofa; stay; studies; study; support; surgery; surgery patients; survival; survivors; table; test; therapy; time; total; transfusion; treatment; unit; use; value; ventilation; volume; years cache: cord-341063-3rqnu5bu.txt plain text: cord-341063-3rqnu5bu.txt item: #402 of 440 id: cord-341088-bqdvx458 author: Rice, Ken title: Effect of school closures on mortality from coronavirus disease 2019: old and new predictions date: 2020-10-07 words: 4931 flesch: 48 summary: similarly, comparing general social distancing with equivalent scenarios without social distancing, the second wave peak in the case isolation, household quarantine, and general social distancing scenario is higher than the first wave peak in the case isolation and household quarantine scenario. Figure 2 provides an explanation for how place closure interventions affect the second wave and why an extra intervention might result in more deaths than the equivalent scenario without this intervention. keywords: data; deaths; distancing; interventions; isolation; number; place; report cache: cord-341088-bqdvx458.txt plain text: cord-341088-bqdvx458.txt item: #403 of 440 id: cord-342680-1cr2ph8x author: Sarpong, Nana O. title: What’s Important: Redeployment of the Orthopaedic Surgeon During the COVID-19 Pandemic: Perspectives from the Trenches date: 2020-04-14 words: 1433 flesch: 49 summary: n Coronavirus disease 2019 (COVID-19) situation report -51 WHO Director-General's opening remarks at the media briefing on COVID-19 Coronavirus fears curtail elective surgeries in NYC amid concern for other patients Here, we share 2 perspectives on this experience, that of orthopaedic surgery residents and of an attending physician: keywords: care; orthopaedic; patients; redeployment cache: cord-342680-1cr2ph8x.txt plain text: cord-342680-1cr2ph8x.txt item: #404 of 440 id: cord-343483-puly7tyv author: Pak, Jamie S. title: A Urology Department's Experience at the Epicenter of the COVID-19 Pandemic date: 2020-06-30 words: 2381 flesch: 44 summary: The volume of COVID-19 patients was quickly increasing and many front-line providers were being quarantined for symptoms and/or exposure. As the ED-ICU gained prominence in the care pathway of COVID-19 patients at CUIMC, we also played an instrumental role in onboarding providers from other specialties to the attending/resident pair role. keywords: care; covid-19; department; icu; patients; resident; urology cache: cord-343483-puly7tyv.txt plain text: cord-343483-puly7tyv.txt item: #405 of 440 id: cord-343555-pre6bzne author: Kalligeros, Markos title: Association of Obesity with Disease Severity among Patients with COVID‐19 date: 2020-04-30 words: 2149 flesch: 48 summary: Moreover, patients who required IMV, were more likely to have had heart disease (aOR 3.41; 95% CI:1.05‐11.06), obesity (BMI=30‐34.9 kg/m2) (aOR 6.85; 95% CI: 1.05‐44.82) or severe obesity (BMI≥35 kg/m2) (aOR 9.99; 95% CI:1.39‐71.69). In our analysis, severe obesity (BMI ≥35 kg/m2) was associated with ICU admission, while history of heart disease and obesity (BMI ≥30 kg/m2) were independently associated with the use of IMV. keywords: admission; covid-19; disease; obesity; patients cache: cord-343555-pre6bzne.txt plain text: cord-343555-pre6bzne.txt item: #406 of 440 id: cord-343973-n5ogyxz7 author: Ip, Andrew title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 words: 4336 flesch: 40 summary: key: cord-343973-n5ogyxz7 authors: Ip, Andrew; Berry, Donald A.; Hansen, Eric; Goy, Andre H.; Pecora, Andrew L.; Sinclaire, Brittany A.; Bednarz, Urszula; Marafelias, Michael; Berry, Scott M.; Berry, Nicholas S.; Mathura, Shivam; Sawczuk, Ihor S.; Biran, Noa; Go, Ronaldo C.; Sperber, Steven; Piwoz, Julia A.; Balani, Bindu; Cicogna, Cristina; Sebti, Rani; Zuckerman, Jerry; Rose, Keith M.; Tank, Lisa; Jacobs, Laurie G.; Korcak, Jason; Timmapuri, Sarah L.; Underwood, Joseph P.; Sugalski, Gregory; Barsky, Carol; Varga, Daniel W.; Asif, Arif; Landolfi, Joseph C.; Goldberg, Stuart L. title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 journal: PLoS One DOI: 10.1371/journal.pone.0237693 sha: doc_id: 343973 cord_uid: n5ogyxz7 Hydroxychloroquine has been touted as a potential COVID-19 treatment. This retrospective observational cohort study of 2512 hospitalized COVID-19 patients within a 13-hospital network did not find the empirical use of hydroxychloroquine with or without co-treatment with azithromycin to be associated with a reduction in mortality (adjusted HR, 0.99 for any hydroxychloroquine during hospitalization keywords: azithromycin; covid-19; drug; hospital; hydroxychloroquine; observational; patients; study; tocilizumab; treatment cache: cord-343973-n5ogyxz7.txt plain text: cord-343973-n5ogyxz7.txt item: #407 of 440 id: cord-344641-rog2h4g7 author: Franco, Cosimo title: Feasibility and clinical impact of out-of-ICU non-invasive respiratory support in patients with COVID-19 related pneumonia date: 2020-08-03 words: 3704 flesch: 43 summary: The overall rate of workers infected, in personnel not specifically involved in the care of COVID-19 patients, in the nine hospitals was 3.8±1.9%. Nevertheless, WHO advocate using CPAP or NIV for the management of respiratory failure in COVID-19 patients, provided that appropriate PPE is worn by the personnel (9) . keywords: care; covid-19; cpap; icu; niv; nrs; patients; rate; study cache: cord-344641-rog2h4g7.txt plain text: cord-344641-rog2h4g7.txt item: #408 of 440 id: cord-344824-myaiilra author: Sha, D. title: Spatiotemporal Analysis of Medical Resource Deficiencies in the U.S. under COVID-19 Pandemic date: 2020-05-25 words: 5741 flesch: 48 summary: [9, 10] . Are U.S. medical resources enough to handle the worst scenario during this crisis? MRDId is large (>1) when local medical resources cannot fully support the hospitalized critically ill patients, or the local medical burden is heavy; and MRDId is small (<1) when local medical resources are sufficient. keywords: beds; care; county; covid-19; data; icu; level; medrxiv; number; preprint cache: cord-344824-myaiilra.txt plain text: cord-344824-myaiilra.txt item: #409 of 440 id: cord-345591-zwh1xj5u author: Al-Dorzi, Hasan M. title: The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study date: 2016-10-24 words: 5885 flesch: 46 summary: The hospital mortality of ICU MERS patients was 63.4 % (0 % for the HCWs). According to the IDEP, one unit (Unit A) was designated as the primary receiving unit for MERS patients, because of its geographic location being away from main hospital traffic and because 7 of its 8 rooms were negative-pressure airborne infection isolation rooms (AIIR). keywords: care; cases; cov; hospital; icu; infection; mers; outbreak; patients; staff; syndrome; unit cache: cord-345591-zwh1xj5u.txt plain text: cord-345591-zwh1xj5u.txt item: #410 of 440 id: cord-345973-fb3gkc0f author: Thibault, Ronan title: Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance date: 2020-07-19 words: 4847 flesch: 42 summary: All over the world, ICU COVID-19 patients are rather similar in terms of vulnerability (older, chronic diseases, low food intake for 5-10 days) To our knowledge, there is no specific indication for arginine in ICU COVID-19 patients. keywords: case; covid-19; icu; malnutrition; nutrition; patients; risk; sars; use cache: cord-345973-fb3gkc0f.txt plain text: cord-345973-fb3gkc0f.txt item: #411 of 440 id: cord-346062-q0trgj12 author: Robert, René title: Ethical dilemmas due to the Covid-19 pandemic date: 2020-06-17 words: 5719 flesch: 40 summary: Indeed, in addition to the elements linked to the lack of available beds, several factors in the decisionmaking process were sources of concern: reduction of the minimum time necessary to make such occasionally life-or-death decisions, decrease due to containment measures in the essential time to be spent with relatives and pressure from the continuous flow of arriving ICU patients. As another application of the societal concept, it has been proposed to prioritize for ICU care the caregivers who have become critically ill, not due to their intrinsic quality or for so as to reward them, but rather for the possibility, once they are cured, of being returning to the operational caregiving circuit keywords: beds; care; covid-19; decision; family; health; icu; life; members; pandemic; patients; risk cache: cord-346062-q0trgj12.txt plain text: cord-346062-q0trgj12.txt item: #412 of 440 id: cord-346229-jxlrz0ce author: Craxì, Lucia title: Rationing in a Pandemic: Lessons from Italy date: 2020-06-16 words: 2411 flesch: 42 summary: A political and public engagement/education in the ethics of resource allocation is needed to clarify priorities and values if they are to be reflected in allocation. Box 1 Key elements of SIAARTI recommendations (Vergano et al. 2020a, b) 1. keywords: allocation; approach; care; italy; patients; recommendations; resources cache: cord-346229-jxlrz0ce.txt plain text: cord-346229-jxlrz0ce.txt item: #413 of 440 id: cord-346495-irtdqbeb author: Ackland, G. J. title: The long term predictions from Imperial College CovidSim Report 9 date: 2020-06-22 words: 3776 flesch: 55 summary: In Table 2 we also report the total number of deaths across the entire simulation, and also the number of deaths at the time when the interventions were 2 Despite the description of place closure interventions in Table 2 of Report 9, university closures are not included in the (PC )CI HQ SDOL70 scenario parameter files (8) 3 . Figure 3 provides an explanation for how place closure interventions affect the second wave, and why an extra intervention may result in more deaths than the equivalent scenario without this intervention. keywords: deaths; icu; interventions; place; report cache: cord-346495-irtdqbeb.txt plain text: cord-346495-irtdqbeb.txt item: #414 of 440 id: cord-346507-w9aaalgo author: Mejia-Vilet, J. M. title: DERIVATION OF A SCORE TO PREDICT ADMISSION TO INTENSIVE CARE UNIT IN PATIENTS WITH COVID-19: THE ABC-GOALS SCORE date: 2020-05-16 words: 4838 flesch: 50 summary: Patients were segregated into a group that required admission to ICU during their hospitalization and a group that never required ICU admission and was already discharged from hospitalization. All patients who remained hospitalized in general wards by the end of the study were discarded for this analysis as it was considered that their risk for ICU admission is still active. . keywords: admission; license; medrxiv; perpetuity; preprint; score; version cache: cord-346507-w9aaalgo.txt plain text: cord-346507-w9aaalgo.txt item: #415 of 440 id: cord-346811-gorp9n1g author: Hippisley-Cox, Julia title: Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people date: 2020-07-31 words: 5111 flesch: 45 summary: key: cord-346811-gorp9n1g authors: Hippisley-Cox, Julia; Young, Duncan; Coupland, Carol; Channon, Keith M; Tan, Pui San; Harrison, David A; Rowan, Kathryn; Aveyard, Paul; Pavord, Ian D; Watkinson, Peter J title: Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people date: 2020-07-31 journal: Heart DOI: 10.1136/heartjnl-2020-317393 sha: doc_id: 346811 cord_uid: gorp9n1g BACKGROUND: There is uncertainty about the associations of angiotensive enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs with COVID-19 disease. Of 19 486 patients who had COVID-19 disease, 1286 received ICU care. keywords: ace; admission; covid-19; disease; icu; inhibitors; patients; risk cache: cord-346811-gorp9n1g.txt plain text: cord-346811-gorp9n1g.txt item: #416 of 440 id: cord-347512-veavzt6d author: Ueland, Thor title: Elevated plasma sTIM-3 levels in severe Covid-19 patients date: 2020-09-21 words: 1928 flesch: 44 summary: Methods We analyzed plasma levels of myeloperoxidase (MPO, neutrophil activation), soluble (s) CD25 and soluble T cell immunoglobulin mucin domain-3 (sTIM-3) (markers of T cell activation and exhaustion) and sCD14 and sCD163 (markers of monocyte/macrophage activation) in 39 COVID-19 infected patients at hospital admission and two additional times during the first 10 days in relation to the need for ICU treatment. Finally, the two markers of T cell activation, sCD25 and sTIM-3, were strongly correlated (r=0.71, p<0.001). keywords: cell; covid-19; icu; levels; patients cache: cord-347512-veavzt6d.txt plain text: cord-347512-veavzt6d.txt item: #417 of 440 id: cord-347662-yk3cz0hq author: Li, Michael title: Tocilizumab in the Management of COVID-19: A Preliminary Report date: 2020-11-09 words: 3302 flesch: 35 summary: For ICU patients, TCZ treatment was not significantly correlated with mortality (p = 0.2344). Interestingly, Tocilizumab was not associated with increased mortality in ICU patients, perhaps because of the severity of the condition and duration of disease. keywords: covid-19; icu; mortality; patients; tocilizumab; treatment; ventilation cache: cord-347662-yk3cz0hq.txt plain text: cord-347662-yk3cz0hq.txt item: #418 of 440 id: cord-347790-7h25gzzl author: Calligaro, Keith D. title: COVID (Co-Operative Vascular Intervention Disease) Team of Greater Philadelphia date: 2020-06-17 words: 2331 flesch: 47 summary: If certain hospitals were overwhelmed by the virus and 10 could not accept transfers such as ruptured AAAs or other vascular patients requiring an ICU bed, 11 other hospitals might have available ICU beds and be able to accept those patients. None imposed age restrictions regarding older VSs continuing clinical hospital work. keywords: groups; hospital; philadelphia; vascular; vss cache: cord-347790-7h25gzzl.txt plain text: cord-347790-7h25gzzl.txt item: #419 of 440 id: cord-347833-b3yrxkt0 author: Ahlström, Björn title: A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort date: 2020-09-04 words: 4346 flesch: 50 summary: Such an approach allows for an accurate assessment of comorbidities in general and pre ICU dementia in particular. The date of dementia diagnosis was the first occurrence of the condition in the NPR or the SveDem. keywords: care; cohort; dementia; diagnosis; icu; patients; risk; sepsis cache: cord-347833-b3yrxkt0.txt plain text: cord-347833-b3yrxkt0.txt item: #420 of 440 id: cord-347935-jfx9037u author: Valdivia, Andrés Reyes title: Adapting vascular surgery practice to the current COVID-19 era at a tertiary academic center in Madrid. date: 2020-06-04 words: 1984 flesch: 47 summary: As described 209 previously, COVID-19 patients can associate a pro-coagulant state which can lead 210 either to deep vein thrombosis (DVT) and /or peripheral arterial thrombosis. Pertaining DVT, a previous description of 23% incidence 213 for COVID-19 patients in ICU and 8% not requiring ventilator demonstrated the 214 importance of such situation in these patients. keywords: covid-19; patients; practice; vascular cache: cord-347935-jfx9037u.txt plain text: cord-347935-jfx9037u.txt item: #421 of 440 id: cord-348137-dzmbfp2g author: Bi, Qifang title: Characterization of clinical progression of COVID-19 patients in Shenzhen, China date: 2020-04-27 words: 4554 flesch: 43 summary: Using data from Shenzhen, China, where all cases were monitored in hospital and symptom profiles and clinical and lab results were available starting from early stages of clinical course, we characterized clinical progression of COVID-19 cases and determined important predictors for faster clinical progression to key clinical events and longer use of medical resources. We estimate time from symptom onset to key clinical events, such as first clinical diagnosis, progression to severe clinical stages, development of acute respiratory distress syndrome (ARDS), admission to the critical care unit (ICU), and discharge. keywords: 95%ci; cases; days; icu; onset; patients; progression; symptom cache: cord-348137-dzmbfp2g.txt plain text: cord-348137-dzmbfp2g.txt item: #422 of 440 id: cord-349263-mmfrqyrc author: Rodríguez, A. title: Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic date: 2020-11-09 words: 4184 flesch: 52 summary: Patients Patients admitted due to COVID-19 and respiratory failure. key: cord-349263-mmfrqyrc authors: Rodríguez, A.; Moreno, G.; Gómez, J.; Carbonell, R.; Picó-Plana, E.; Benavent Bofill, C.; Sánchez Parrilla, R.; Trefler, S.; Esteve Pitarch, E.; Canadell, L.; Teixido, X.; Claverias, L.; Bodí, M. title: Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic date: 2020-11-09 journal: nan DOI: 10.1016/j.medine.2020.05.005 sha: doc_id: 349263 cord_uid: mmfrqyrc Objective To describe the clinical and respiratory characteristics of a cohort of 43 patients with COVID-19 after an evolutive period of 28 days. keywords: admission; covid-19; days; icu; imv; mortality; patients; rate; study cache: cord-349263-mmfrqyrc.txt plain text: cord-349263-mmfrqyrc.txt item: #423 of 440 id: cord-349516-00qqpkfd author: Jonmarker, S. title: DOSING OF THROMBOPROPHYLAXIS AND MORTALITY IN CRITICALLY ILL COVID-19 PATIENTS date: 2020-09-23 words: 4068 flesch: 49 summary: The three groups consisted of 67 patients who received low dose thromboprophylaxis, 48 patients who received medium dose thromboprophylaxis and 37 patients who received high dose thromboprophylaxis. Daily doses of tinzaparin and dalteparin were defined as low dose thromboprophylaxis (2500-4500 international units, IU, tinzaparin or 2500-5000 IU dalteparin), medium dose thromboprophylaxis (>4500 IU but <175 IU/kg of body weight tinzaparin or >5000 IU but <200 IU/kg of body weight dalteparin), and high dose thromboprophylaxis(≥ 175 IU/kg of body weight tinzaparin or ≥ 200 IU/kg of body weight dalteparin). keywords: author; dose; funder; medrxiv; patients; preprint; thromboprophylaxis cache: cord-349516-00qqpkfd.txt plain text: cord-349516-00qqpkfd.txt item: #424 of 440 id: cord-349558-vof63qat author: Jain, Vageesh title: Systematic review and meta-analysis of predictive symptoms and comorbidities for severe COVID-19 infection date: 2020-03-16 words: 4506 flesch: 47 summary: Figure 2 illustrates the proportion of included studies which met each individual appraisal indicator. The clinical spectrum of COVID−19 disease is varied, and identifying factors associated with severe disease has been described as an urgent research priority. keywords: comorbidities; disease; icu; medrxiv; preprint; studies; symptoms cache: cord-349558-vof63qat.txt plain text: cord-349558-vof63qat.txt item: #425 of 440 id: cord-350240-bmppif8g author: Girardi, Paolo title: Robust inference for nonlinear regression models from the Tsallis score: application to COVID‐19 contagion in Italy date: 2020-08-12 words: 3230 flesch: 50 summary: key: cord-350240-bmppif8g authors: Girardi, Paolo; Greco, Luca; Mameli, Valentina; Musio, Monica; Racugno, Walter; Ruli, Erlis; Ventura, Laura title: Robust inference for nonlinear regression models from the Tsallis score: application to COVID‐19 contagion in Italy date: 2020-08-12 journal: Stat (Int Stat Inst) DOI: 10.1002/sta4.309 sha: doc_id: 350240 cord_uid: bmppif8 g We discuss an approach of robust fitting on nonlinear regression models, both in a frequentist and a Bayesian approach, which can be employed to model and predict the contagion dynamics of COVID‐19 in Italy. keywords: data; model; scoring; tsallis cache: cord-350240-bmppif8g.txt plain text: cord-350240-bmppif8g.txt item: #426 of 440 id: cord-350390-ukoi8jyg author: Demkina, A. E. title: Risk factors for outcomes of COVID-19 patients: an observational study of 795 572 patients in Russia date: 2020-11-04 words: 4095 flesch: 45 summary: key: cord-350390-ukoi8jyg authors: Demkina, A. E.; Morozov, S.; Vladzymyrskyy, A. V.; Kljashtorny, V. G.; Guseva, O. I.; Pugachev, P. S.; Artemova, O. R.; Reshetnikov, R. V.; Gombolevskiy, V. A.; Ryabinina, M. N. title: Risk factors for outcomes of COVID-19 patients: an observational study of 795 572 patients in Russia date: 2020-11-04 journal: nan DOI: 10.1101/2020.11.02.20224253 sha: doc_id: 350390 cord_uid: ukoi8jyg Background Several factors that could affect survival and clinical outcomes of COVID-19 patients require larger studies and closer attention. Patients All subjects, regardless of age, admitted to 4,251 Russian hospitals indexed in the Federal Register of COVID-19 patients between March 26, 2020, and June 3, 2020. keywords: covid-19; medrxiv; patients; preprint; risk; study cache: cord-350390-ukoi8jyg.txt plain text: cord-350390-ukoi8jyg.txt item: #427 of 440 id: cord-351264-zp41u14l author: Quah, Pipetius title: Mortality rates of patients with COVID-19 in the intensive care unit: a systematic review of the emerging literature date: 2020-06-04 words: 701 flesch: 48 summary: Third, 29% of the ICU patients who died in the Chinese studies did not receive mechanical ventilation, and where systems experienced a surge of critically ill patients, up to 53.2% of patients who required ICU care were unable to receive it because of resource constraints We thus aimed to review the outcomes of ICU patients with COVID-19 from the existing literature. keywords: icu; patients cache: cord-351264-zp41u14l.txt plain text: cord-351264-zp41u14l.txt item: #428 of 440 id: cord-351735-x1lng449 author: Flikweert, Antine W. title: Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series date: 2020-07-08 words: 2685 flesch: 34 summary: Often an atypical high compliance phenotype (L-type) is observed during mechanical ventilation in COVID-19 patients in contrast to mechanical ventilation characteristics typically seen in ARDS with low lung compliance phenotype (H -type). The cumulative incidence of venous thromboembolism reported was 49% in COVID-19 patients admitted to the ICU. keywords: aspergillosis; case; covid-19; icu; organizing; patients; pneumonia cache: cord-351735-x1lng449.txt plain text: cord-351735-x1lng449.txt item: #429 of 440 id: cord-351943-ouukwv73 author: Frobert, Emilie title: Respiratory viruses in children admitted to hospital intensive care units: Evaluating the CLART® Pneumovir DNA array, , date: 2010-11-24 words: 3488 flesch: 49 summary: Cloning of a human parvovirus by molecular screening of respiratory tract samples Human bocavirus and acute wheezing in children Detection of human metapneumovirus RNA sequences in nasopharyngeal aspirates of young French children with acute bronchiolitis by real-time reverse transcriptase PCR and phylogenetic analysis Multiple simultaneous viral infections in infants with acute respiratory tract infections Dual priming oligonucleotide system for the multiplex detection of respiratory viruses and SNP genotyping of CYP2C19 gene Comparison of multiplex PCR assays and conventional techniques for the diagnostic of respiratory virus infections in children admitted to hospital with an acute respiratory illness Human bocavirus: A novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Incidence, molecular epidemiology and clinical presentations of human metapneumovirus; Assessment of its importance as a diagnostic screening target Human bocavirus infection in young children in the United States: Molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Simultaneous detection and high-throughput identification of a panel of RNA viruses causing respiratory tract infections Detection of respiratory viruses by molecular methods Development of a respiratory virus panel test for detection of twenty human respiratory viruses by use of multiplex PCR and a fluid microbead-based assay Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses In very young infants severity of acute bronchiolitis depends on carried viruses Evaluation of a multiplexed PCR assay for detection of respiratory viral pathogens in a public health laboratory setting Molecular and clinical characteristics of respiratory syncytial virus infections in hospitalized children Sole pathogen in acute bronchiolitis: Is there a role for other organisms apart from respiratory syncytial virus? Mixed respiratory virus infections RespiFinder: keywords: cases; children; infections; rsv; viruses cache: cord-351943-ouukwv73.txt plain text: cord-351943-ouukwv73.txt item: #430 of 440 id: cord-352065-960xqft4 author: Rello, Jordi title: Update in COVID-19 in the Intensive Care Unit from the 2020 HELLENIC Athens International Symposium date: 2020-10-22 words: 4979 flesch: 32 summary: Regarding detection and diagnosis, studies have used machine learning algorithms to predict the criticality of COVID-19 positive patients using clinical features and identifying which of them have statistically significant hazard errors [64, 65] . COVID-19 infection has shown a great variability in terms of mortality in different regions around the globe. keywords: coronavirus; cov-2; covid-19; disease; icu; infection; lung; pandemic; patients; phenotype; pneumonia; sars cache: cord-352065-960xqft4.txt plain text: cord-352065-960xqft4.txt item: #431 of 440 id: cord-352280-nn1rgdw0 author: Mayorga, Lía title: Detection and isolation of asymptomatic individuals can make the difference in COVID-19 epidemic management date: 2020-04-29 words: 4337 flesch: 47 summary: We assumed the detection and isolation of 50% of asymptomatic individuals in day 3. Efficient removal of asymptomatic infectious individuals from circulation has dramatic effects on healthcare burden and fatality over the total population, mainly when R remains at the lower end. key: cord-352280-nn1rgdw0 authors: Mayorga, Lía; García Samartino, Clara; Flores, Gabriel; Masuelli, Sofía; Sánchez, María Victoria; Mayorga, Luis S.; Sánchez, Cristián Gabriel title: Detection and isolation of asymptomatic individuals can make the difference in COVID-19 epidemic management date: 2020-04-29 journal: nan DOI: 10.1101/2020.04.23.20077255 sha: doc_id: 352280 cord_uid: nn1rgdw0 Mathematical modeling of infectious diseases is a powerful tool for the design of management policies and a fundamental part of the arsenal currently deployed to deal with the COVID-19 pandemic. keywords: asymptomatic; individuals; license; medrxiv; model; preprint cache: cord-352280-nn1rgdw0.txt plain text: cord-352280-nn1rgdw0.txt item: #432 of 440 id: cord-353069-xkb3xy6k author: Vellieux, Geoffroy title: COVID-19 associated encephalopathy: is there a specific EEG pattern? date: 2020-06-24 words: 1162 flesch: 44 summary: EEG reports are still scarce among literature dedicated to COVID-19 patients and found normal or nonspecific results (Filatov et al. 2020; Opposite outcomes despite similar EEG patterns of the two present patients suggest that these EEG figures are not predictive for neurological prognosis but may represent a signature of SARS-CoV-2 infection. keywords: covid-19; eeg; icu; patients cache: cord-353069-xkb3xy6k.txt plain text: cord-353069-xkb3xy6k.txt item: #433 of 440 id: cord-353398-jrz163v2 author: van Arkel, Andreas L. E. title: COVID-19–associated Pulmonary Aspergillosis date: 2020-07-01 words: 1318 flesch: 43 summary: key: cord-353398-jrz163v2 authors: van Arkel, Andreas L. E.; Rijpstra, Tom A.; Belderbos, Huub N. A.; van Wijngaarden, Peter; Verweij, Paul E.; Bentvelsen, Robbert G. title: COVID-19–associated Pulmonary Aspergillosis date: 2020-07-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202004-1038le sha: doc_id: 353398 cord_uid: jrz163v2 nan Netherlands emerged as a hotspot for COVID-19, and we noticed cases of invasive pulmonary aspergillosis (IPA) occurring in patients with COVID-19 admitted to the ICU. There were no significant differences in clinical characteristics between ICU patients with COVID-19 with presumed CAPA and those without presumed CAPA (Table 2) . keywords: capa; covid-19; icu; patients cache: cord-353398-jrz163v2.txt plain text: cord-353398-jrz163v2.txt item: #434 of 440 id: cord-353890-dzauzjm7 author: Guzzi, Pietro Hiram title: Spatio-Temporal Resource Mapping for Intensive Care Units at Regional Level for COVID-19 Emergency in Italy date: 2020-05-12 words: 2162 flesch: 52 summary: By using infections vs ICU beds trend, we were able to calculate the number of infections for some time point in the future and derive the number of predicted ICU beds which will be occupied. COVID-19 patients management requires availability of sufficiently large number of Intensive Care Units (ICUs) beds. keywords: beds; covid-19; icu; icus; patients cache: cord-353890-dzauzjm7.txt plain text: cord-353890-dzauzjm7.txt item: #435 of 440 id: cord-354167-j6l3hq1h author: Algassim, Abdulrahman A. title: Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in SARS-CoV-2 infection date: 2020-09-12 words: 3642 flesch: 52 summary: In COVID-19 patients, iatrogenic active bleeding [14] or secondary to disseminated intravascular coagulation (DIC) can also potentially contribute to anemia We demonstrate a relationship between hemoglobin level at presentation and the disease course among COVID-19 patients. keywords: anemic; covid-19; fig; hgb; icu; patients cache: cord-354167-j6l3hq1h.txt plain text: cord-354167-j6l3hq1h.txt item: #436 of 440 id: cord-354194-hf5ndv5f author: Cook, Mackenzie title: Prioritizing Communication in the Provision of Palliative Care for the Trauma Patient date: 2020-10-29 words: 7936 flesch: 38 summary: We are strangers walking into their life-changing event: how prehospital providers manage emergency calls at the end of life Missed opportunities: integrating palliative care into the emergency department for older adults presenting as level I triage priority from long-term care facilities Preadmission Do Not Resuscitate advanced directive is associated with adverse outcomes following acute traumatic injury Experiences with POLST: opportunities for improving advance care planning: Editorial & Comment on Association between physician orders for life-sustaining treatment for scope of treatment and in-hospital death in Oregon Injured older adults transported by emergency medical services: one year outcomes by POLST status Physician orders for life-sustaining treatment (POLST): lessons learned from analysis of the Oregon POLST Registry Lessons from Oregon in Embracing Complexity in End-of-Life Care A comparison of methods to communicate treatment preferences in nursing facilities: traditional practices versus the physician orders for life-sustaining treatment program Family presence during resuscitation after trauma Family presence during trauma resuscitation: ready for primetime? Effects of family-witnessed resuscitation after trauma prior to hospitalization Experiences of families when present during resuscitation in the emergency department after trauma Family presence during trauma resuscitation: family members' attitudes, behaviors, and experiences Family presence during cardiopulmonary resuscitation 153-60 Propensitymatched study showing that POLST forms available in the early phases of trauma care do indeed alter the management of patients and that, when specified Palliative care interventions for surgical patients: a systematic review Structure and function of a trauma intensive care unit: a report from the Trauma Intensive Care Unit Prevalence Project A structured approach to supporting communciation with families in the ICU can improve family perceptions of the patient and family centeredness of the care as well as reduce hospital length of stay Effect of palliative care-led meetings for families of patients with chronic critical illness: a randomized clinical trial Identifying patients in need of a palliative care assessment in the hospital setting: a consensus report from the Center to Advance Palliative Care 1173-5 An outline of the model of palliative care that may be the most successful-primary palliative care from the ICU team with subspecialty consultation The costs of waiting: implications of the timing of palliative care consultation among a cohort of decedents at a comprehensive cancer center To operate or not to operate? Primary palliative care (PPC) is defined as palliative care provided by the primary treating service. keywords: care; communication; decision; end; family; goals; icu; injury; life; palliative; patients; team; trauma cache: cord-354194-hf5ndv5f.txt plain text: cord-354194-hf5ndv5f.txt item: #437 of 440 id: cord-355028-1x7w1749 author: Piazza, Cesare title: Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society date: 2020-06-06 words: 4323 flesch: 27 summary: key: cord-355028-1x7w1749 authors: Piazza, Cesare; Filauro, Marta; Dikkers, Frederik G.; Nouraei, S. A. Reza; Sandu, Kishore; Sittel, Christian; Amin, Milan R.; Campos, Guillermo; Eckel, Hans E.; Peretti, Giorgio title: Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society date: 2020-06-06 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06112-6 sha: doc_id: 355028 cord_uid: 1x7w1749 INTRODUCTION: COVID-19 patients admitted to the ICU often require prolonged mechanical ventilation with high positive endexpiratory pressure through an endotracheal tube, with a frequency reported as high as 88% in a series of 1591 consecutive patients treated at 72 hospitals included in the COVID-19 Lombardy ICU Network, Italy keywords: airway; conditions; covid-19; endotracheal; icu; intubation; laryngotracheal; lts; patients; stenosis; tracheostomy cache: cord-355028-1x7w1749.txt plain text: cord-355028-1x7w1749.txt item: #438 of 440 id: cord-355038-o2hr5mox author: None title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: 102622 flesch: 49 summary: No significant difference between the NE and AVP groups for lactate clearance between H0 and H6 (25.6 [− 7.31 to 35.34]% vs 47.84 [13.42-82.73 ]%, p = 0.686). D: blood frequency of MAIT cells in patients with pneumonia compared with healthy controls (as % of total T cells) keywords: 0.001; acute; admission; adult patients; age; aim; aki; analysis; antibiotic; ards; ards patients; association; blood; cardiac; care; care patients; care unit; cases; characteristics; children; cohort; compliance; complications; conclusion; conflict; control; data; days; death; diagnosis; disclosure; disease; duration; dysfunction; early; ecmo; end; ethics regulations; factors; failure; fig; following; france; group; high; hospital; hospital mortality; icu admission; icu mortality; icu patients; icu stay; impact; incidence; infection; influenza patients; injury; intensive; intensive care; interest; international; intubation; january; length; management; mean; median; medical; methods; model; months; mortality; mortality rate; multivariate; n =; national; niv; non; objective; outcome; p =; patients; period; pneumonia; post; pressure; prognosis; pulmonary; rate; rationale; respiratory; results; risk; score; sepsis; septic; severity; shock; sofa; stay; studies; study; study period; support; survival; syndrome; therapy; time; total; treatment; unit; use; ventilation; weaning; years cache: cord-355038-o2hr5mox.txt plain text: cord-355038-o2hr5mox.txt item: #439 of 440 id: cord-355410-oinbicza author: Kormann, Raphaël title: Coronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injury date: 2020-06-08 words: 3937 flesch: 40 summary: After excluding the two ICU patients with glomerular rank proteinuria (>3000 mg/g), other ICU patients were more likely to experience a significantly increased tubular proteinuria (mg/g) than other inpatients, as shown in Figure 1B During hospitalization, 22 patients (19 in ICU versus 3 other inpatients, P ¼ 0.008) had two or more evaluations of proximal tubular injury during their hospitalization. At the time of the first renal evaluation, ICU patients presented more frequent (96 versus 62%, P = 0.0095) and more severe (844 ± 343 versus 350 ± 221 mg/g, P = 0.0001) proteinuria, and a trend for an increased number of proximal tubule abnormalities (P = 0.038). keywords: acute; aki; covid-19; fanconi; icu; injury; kidney; patients; syndrome cache: cord-355410-oinbicza.txt plain text: cord-355410-oinbicza.txt item: #440 of 440 id: cord-356371-w9ejgzvu author: Torres-González, JI title: What has happened to care during the COVID-19 pandemic? date: 2020-07-28 words: 2276 flesch: 38 summary: -Benchmark ECMO Units with a well defined team (ECMO-Team) were able to quickly implement this therapy to a larger number of patients and to adapt care required by this type of patient with the COVID pathology. What may be a complex decision was greatly simplified with COVID-19 patients because it was highly evident when treatment did not work. keywords: care; icu; patients; sedation; seeiuc cache: cord-356371-w9ejgzvu.txt plain text: cord-356371-w9ejgzvu.txt