item: #1 of 303 id: cord-000131-ugbwvy6j author: Jones, James Holland title: Early Assessment of Anxiety and Behavioral Response to Novel Swine-Origin Influenza A(H1N1) date: 2009-12-03 words: 4326 flesch: 42 summary: To evaluate the hypothesis that respondents' affective state (subjective anxiety, fatalism about infection) predicts protective measures, we include in the model demographic (age, gender), epidemiological (household size, number of contacts, survey day), and media (source of information on the outbreak) conditioning variables. To develop a measure for this, we cross-tabulated individual values of the protection index and affective status by survey day. keywords: health; influenza; information; media; number; people; respondents; risk; survey cache: cord-000131-ugbwvy6j.txt plain text: cord-000131-ugbwvy6j.txt item: #2 of 303 id: cord-000161-hxjxczyr author: Rello, Jordi title: Clinical review: Primary influenza viral pneumonia date: 2009-12-21 words: 3655 flesch: 29 summary: The real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) Swine Flu Panel for detection of pandemic H1N1 influenza, developed by the Centers for Disease Control and Prevention (Atlanta, GA, USA) and distributed to many laboratories in US and worldwide, is a reliable and timely method of diagnosing the pandemic strain [32, 33] . [35] and unacceptably insensitive for the detection of pandemic H1N1 influenza keywords: acute; h1n1; infection; influenza; pandemic; patients; pneumonia; strain; virus cache: cord-000161-hxjxczyr.txt plain text: cord-000161-hxjxczyr.txt item: #3 of 303 id: cord-000244-wrru98zg author: Pfeil, Alena title: A cross-sectional survey to evaluate knowledge, attitudes and practices (KAP) regarding seasonal influenza vaccination among European travellers to resource-limited destinations date: 2010-07-07 words: 1744 flesch: 37 summary: key: cord-000244-wrru98zg authors: Pfeil, Alena; Mütsch, Margot; Hatz, Christoph; Szucs, Thomas D title: A cross-sectional survey to evaluate knowledge, attitudes and practices (KAP) regarding seasonal influenza vaccination among European travellers to resource-limited destinations date: 2010-07-07 journal: BMC Public Health DOI: 10.1186/1471-2458-10-402 sha: doc_id: 244 cord_uid: wrru98zg BACKGROUND: Influenza is one of the most common vaccine-preventable diseases in travellers. By performing two cross-sectional questionnaire surveys during winter 2009 and winter 2010 among European travellers to resource-limited destinations, we aimed to investigate knowledge, attitudes and practices (KAP) regarding seasonal influenza vaccination. keywords: influenza; risk; travel; travellers; vaccination cache: cord-000244-wrru98zg.txt plain text: cord-000244-wrru98zg.txt item: #4 of 303 id: cord-000262-4owsb0bg author: Leung, Gabriel M. title: Reflections on Pandemic (H1N1) 2009 and the International Response date: 2010-10-05 words: 4617 flesch: 36 summary: Rapid operations to contain the initial emergence of pandemic influenza The role of the Health Protection Agency in the 'containment' phase during the first wave of pandemic influenza in England Influenza Pandemic: An independent review of the UK response to the 2009 influenza pandemic Influenza (H1N1) 2009 outbreak and school closure Closure of schools during an influenza pandemic Facemasks and hand hygiene to prevent influenza transmission in households: a cluster randomized trial Household transmission of 2009 influenza A (H1N1) virus after a school-based outbreak Household transmission of 2009 pandemic influenza A (H1N1) virus in the United States Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial Antiviral treatment for patients hospitalized with 2009 pandemic influenza A (H1N1) A new decade, a new seasonal influenza: the Council of the European Union Recommendation on seasonal influenza vaccination Estimates of the transmissibility of the 1968 (Hong Kong) influenza pandemic: evidence of increased transmissibility between successive waves Emerging infectious diseases: a 10-year perspective from the National Institute of Allergy and Infectious Diseases Early observational research and registries during the 2009-2010 influenza A pandemic Studies needed to address public health challenges of the 2009 H1N1 influenza pandemic: insights from modeling Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer 2009: four observational studies from Canada Global pandemic influenza action plan to increase vaccine supply We thank Timothy M. Uyeki of the US Centers for Disease Control and Prevention for substantial discussion and input. keywords: countries; data; h1n1; health; influenza; pandemic; public; transmission; vaccine; virus cache: cord-000262-4owsb0bg.txt plain text: cord-000262-4owsb0bg.txt item: #5 of 303 id: cord-000390-qav5okgk author: Omer, Saad B. title: Maternal Influenza Immunization and Reduced Likelihood of Prematurity and Small for Gestational Age Births: A Retrospective Cohort Study date: 2011-05-31 words: 5698 flesch: 31 summary: We used logistic regression to evaluate the association of maternal influenza vaccine and (a) prematurity and (b) SGA. Briefly, variables for each birth outcome were evaluated for potential confounding by selecting the covariates that, in bivariate models, modified the association between maternal influenza vaccine and the birth outcome and moved the OR towards 1. keywords: activity; birth; influenza; influenza activity; influenza vaccine; period; pregnancy; vaccine cache: cord-000390-qav5okgk.txt plain text: cord-000390-qav5okgk.txt item: #6 of 303 id: cord-000724-lzhobnch author: ZHANG, J. title: Seasonal influenza vaccination knowledge, risk perception, health beliefs and vaccination behaviours of nurses date: 2011-11-18 words: 3528 flesch: 37 summary: Recommendations of the Advisory Committee on Immunization Practices (ACIP) Prioritization strategies for pandemic influenza vaccine in 27 countries of the European Union and the Global Health Security Action Group : a review National seasonal influenza vaccination survey in Europe Influenza vaccination coverage rates in five European countries during season 2006/07 and trends over six consecutive seasons Influenza vaccination among primary healthcare workers Influenza vaccination acceptance among health-care workers : a nationwide survey Influenza vaccination uptake monitoring on behalf of the Department of Health Attitudes, knowledge and factors related to acceptance of influenza vaccine by pediatric healthcare workers Correlation between healthcare workers' knowledge of influenza vaccine and vaccine receipt Factors affecting nurses' decision to get the flu vaccine Factors affecting influenza vaccine uptake among health care workers Knowledge and attitudes about influenza vaccination amongst general practitioners, practice nurses, and people aged 65 and over Influenza vaccination coverage among hospital personnel over three consecutive vaccination campaigns Influenza vaccination rates and motivators among healthcare worker groups Influenza vaccination in paediatric nurses : cross-sectional study of coverage, refusal, and factors in acceptance Predictors of influenza vaccination amongst Australian nurses Impact of severe acute respiratory syndrome and the perceived avian influenza epidemic on the increased rate of influenza vaccination among nurses in Hong Kong Influenza vaccination among registered nurses : information receipt, knowledge, and decision-making at an institution with a multifaceted educational program Understanding healthcare worker uptake of influenza vaccination : a survey Accessed Trends in influenza vaccination coverage rates in the United Kingdom over six seasons from 2001-2 to 2006-7 Pandemic H1N1 (swine flu) and seasonal influenza vaccine uptake amongst frontline healthcare workers in England Avian flu : the creation of expectations in the interplay between science and the media Development of the multidimensional health locus of control (MHLC) scales Policy statementrecommendation for mandatory influenza immunization of all health care personnel Revised SHEA position paper : influenza vaccination of healthcare personnel Mandatory vaccination of health care workers The ethics of mandatory vaccination against influenza for health care workers Point counterpoint : mandatory flu vaccination for health care workers Beliefs on mandatory influenza vaccination of health care workers in nursing homes : a questionnaire study from the Netherlands Sensitivity and specificity of patient self-report of influenza and pneumococcal polysaccharide vaccinations among elderly outpatients in diverse patient care strata We are grateful for the statistical advice of Peter Milligan. [27] , further studies are needed to explore the influences on nurses' attitudes and practices regarding influenza vaccination and to identify the major influencing factors for their vaccination behaviours. keywords: health; influenza; knowledge; nurses; perception; risk; vaccination cache: cord-000724-lzhobnch.txt plain text: cord-000724-lzhobnch.txt item: #7 of 303 id: cord-000757-bz66g9a0 author: Davis, Kailah title: Identification of pneumonia and influenza deaths using the death certificate pipeline date: 2012-05-08 words: 6167 flesch: 46 summary: Pneumonia deaths include deaths from all types of pneumonia including pneumonia due to H. influenza and pneumonia due to parainfluenzae virus. For both comparators, the deaths were counted and categorized as TRUE POSI-TIVES (cases found by the comparator-pneumonia deaths being correctly classified); FALSE POSITIVES (incorrect cases found by the comparator-the number of pneumonia and influenza deaths incorrectly identified by the comparator); FALSE NEGATIVES (correct cases not found by the comparator-the number of pneumonia deaths not identified by the comparator). keywords: cases; certificates; codes; data; death; death certificates; influenza; mortality; pneumonia; records; surveillance; system cache: cord-000757-bz66g9a0.txt plain text: cord-000757-bz66g9a0.txt item: #8 of 303 id: cord-000759-36dhfptw author: Uribe-Sánchez, Andrés title: Predictive and Reactive Distribution of Vaccines and Antivirals during Cross-Regional Pandemic Outbreaks date: 2011-06-05 words: 6946 flesch: 38 summary: A population-dynamic model for evaluating the potential spread of drug-resistant Influenza virus infections during community-based use of antivirals Economic analysis of Influenza vaccination and antiviral treatment for healthy working adults Antiviral resistance and the control of pandemic Influenza A small community model for the transmission of infectious diseases: comparison of School closure as an intervention in individual-based models of an Influenza pandemic Measures against transmission of pandemic H1N1 Influenza in Japan in 2009: simulation model Responding to simulated pandemic Simulation suggests that rapid activation of social distancing can arrest epidemic development due to a novel strain of Influenza Analysis of the effectiveness of interventions used during the 2009 A/H1N1 Influenza pandemic On estimation of vaccine efficacy using validation samples with selection bias Targeted social distancing design for pandemic Influenza Living with Influenza: impacts of government imposed and voluntarily selected interventions Containing pandemic Influenza with antiviral agents Reducing the impact of the next Influenza pandemic using household-based public health interventions Transmissibility of 1918 pandemic Influenza Finding optimal vaccination strategies for pandemic Influenza using genetic algorithms Modeling the worldwide spread of pandemic Influenza: baseline case and containment interventions Using Influenza-like illness data to reconstruct an Influenza outbreak FluTE, a publicly available stochastic Influenza epidemic simulation model Models of Infectious Disease Agent Study Strategies for containing an emerging Influenza pandemic in Southeast Asia Containing pandemic Influenza at the source Strategies for mitigating an Influenza pandemic Mitigation strategies for pandemic Influenza in the United States Modelling disease outbreaks in realistic urban social networks Modeling targeted layered containment of an Influenza pandemic in the United States Report from the Models of Infectious Disease Agent Study (MIDAS) Steering Committee Modeling community containment for pandemic Influenza: a letter report Interim pre-pandemic planning guidance: community strategy for pandemic Influenza mitigation in the United States The economic impact of pandemic Influenza in the United States: priorities for intervention A large scale simulation model for assessment of societal risk and development of dynamic mitigation strategies Pandemic Influenza: quarantine, isolation and social distancing Spatial considerations for the allocation of pre-pandemic Influenza vaccination in the United States Statistical Models and Methods for Lifetime Data Mathematical Epidemiology of Infectious Diseases: Model Building, Analysis and Interpretation Deaths from bacterial pneumonia during 1918-19 Influenza pandemic CDC Influenza operational plan WHO guidelines on the use of vaccine and antivirals during Influenza pandemics Influenza A(H1N1) Monovalent Vaccine Public response to community mitigation measures for pandemic Influenza Precautionary behavior in response to perceived threat of pandemic Influenza The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital A infections Initial human transmission dynamics of the pandemic (H1N1) 2009 virus in North America Quantifying the routes of transmission for pandemic Influenza Little evidence for genetic susceptibility to Influenza A (H5N1) from family clustering data Estimating variability in the transmission of severe acute respiratory syndrome to household contacts in Hong Kong, China The transmissibility and control of pandemic Influenza a (H1N1) virus Detecting human-to-human transmission of avian Influenza A (H5N1) keywords: antiviral; availability; cost; impact; influenza; model; outbreak; pandemic; region; regional; resource; simulation; total cache: cord-000759-36dhfptw.txt plain text: cord-000759-36dhfptw.txt item: #9 of 303 id: cord-000760-4yfohp9w author: Babapoor, Sankhiros title: A Novel Vaccine Using Nanoparticle Platform to Present Immunogenic M2e against Avian Influenza Infection date: 2012-01-12 words: 6091 flesch: 46 summary: Detection of antibodies to the nonstructural protein (NS1) of avian influenza viruses allows distinction between vaccinated and infected chickens The use of vaccination to combat multiple introductions of Notifiable Avian Influenza viruses of the H5 and H7 subtypes between 2000 and 2006 in Italy Avian influenza vaccination in North America: strategies and difficulties Avian influenza vaccines and therapies for poultry Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds Genetics of influenza viruses Passively transferred monoclonal antibody to the M2 protein inhibits influenza Most of these vaccines are killed virus vaccines that induce short-lived immunity and are lacking a broad cross-reactive humoral immune response. keywords: avian; challenge; chickens; influenza; lpai; m2e; mono; nanoparticle; peptide; protection; protein; shedding; tetrameric; vaccine; virus cache: cord-000760-4yfohp9w.txt plain text: cord-000760-4yfohp9w.txt item: #10 of 303 id: cord-000891-5r2in1gw author: Giannella, Maddalena title: Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date: 2012-06-14 words: 4120 flesch: 39 summary: Multivariate analysis showed admission to the surgical ICU (odds ratio (OR), 37.1; 95% confidence interval (CI), 2.1 to 666.6; P = 0.01) and localized infiltrate on chest radiograph (OR, 27.8; 95% CI, 1.3 to 584.1; P = 0.03) to be independent risk factors for unsuspected influenza. A logistic binary model was used to analyze the independent risk factors for unsuspected influenza and 30-day mortality. keywords: admission; cases; diagnosis; hospital; icu; influenza; pandemic; patients; samples cache: cord-000891-5r2in1gw.txt plain text: cord-000891-5r2in1gw.txt item: #11 of 303 id: cord-001154-7k59ogn0 author: Memoli, Matthew J. title: The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts date: 2013-11-01 words: 3914 flesch: 26 summary: Immunocompromised patients with influenza had more severe disease/complications, longer viral shedding, and more antiviral resistance while demonstrating less clinical symptoms and signs on clinical assessment. Immunocompromised patients are at risk for more severe or complicated influenza induced disease, which may be difficult to prevent with existing vaccines and antiviral treatments. keywords: group; individuals; infection; influenza; patients; resistance; study; symptoms; virus cache: cord-001154-7k59ogn0.txt plain text: cord-001154-7k59ogn0.txt item: #12 of 303 id: cord-001219-517gka4h author: Timpka, Toomas title: Intentions to Perform Non-Pharmaceutical Protective Behaviors during Influenza Outbreaks in Sweden: A Cross-Sectional Study following a Mass Vaccination Campaign date: 2014-03-07 words: 5809 flesch: 32 summary: We administered a cross-sectional telephone survey to a representative sample (n = 443) of the Swedish adult population to examine whether self-reported intentions to improve personal hygiene and increase social distancing during influenza outbreaks could be explained by trust in official information, self-reported health (SF-8), sociodemographic factors, and determinants postulated in protection motivation theory, namely threat appraisal and coping appraisal. Protective behavior associated with influenza outbreaks has also been investigated with regard to general estimates of health status [15] , but few studies have used validated measures of self-rated health as a means for the sub categorization. keywords: appraisal; behaviors; health; influenza; intention; model; outbreaks; self; study; threat cache: cord-001219-517gka4h.txt plain text: cord-001219-517gka4h.txt item: #13 of 303 id: cord-001289-qbct63p4 author: Lipsitch, Marc title: Ethical Alternatives to Experiments with Novel Potential Pandemic Pathogens date: 2014-05-20 words: 4484 flesch: 28 summary: [database The feasibility of using high resolution genome sequencing of influenza A viruses to detect mixed infections and quasispecies Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community Human-to-human transmission of H7N9 in a family: 'probable' vs 'possible Novel H7N9 influenza virus shows low infectious dose, high growth rate, and efficient contact transmission in the guinea pig model Human infection with avian influenza virus-update Accessed 28 Pandemic influenza viruses-hoping for the road not taken Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity Stability-mediated epistasis constrains the evolution of an influenza protein Prevalence of epistasis in the evolution of influenza A surface proteins Development of an influenza virologic risk assessment tool Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential Pandemic influenza planning Biology's brave new world: the promise and perils of the synbio revolution Flu season: an interview with Jeffery K. Taubenberger, Chief of the Viral Pathogenesis and Evolution Section at the US National Institute of Allergy and Infectious Diseases The ferret as a model organism to study influenza A virus infection Considerations regarding appropriate sample size for conducting ferret transmission experiments H5N1 influenza viruses: facts, not fear Avian influenza: ferret H7N9 flu model questioned Guiding outbreak management by the use of influenza A(H7Nx) virus sequence analysis Molecular determinants of adaptation of highly pathogenic avian influenza H7N7 viruses to efficient replication in the human host Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N Codon usage biases of influenza virus H7N9 influenza viruses are transmissible in ferrets by respiratory droplet Comparison of the levels of infectious virus in respirable aerosols exhaled by ferrets infected with influenza viruses exhibiting diverse transmissibility phenotypes The M segment of the 2009 new pandemic H1N1 influenza virus is critical for its high transmission efficiency in the guinea pig model Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets Influenza virus hemagglutinin stalk-based antibodies and vaccines Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure Universal vaccine against influenza virus: linking TLR signaling to anti-viral protection Report of the 5th meeting on influenza vaccines that induce broad spectrum and long-lasting immune responses, World Health Organization The universal epitope of influenza A viral neuraminidase fundamentally contributes to enzyme activity and viral replication IFITM3 restricts the morbidity and mortality associated with influenza Synthetic generation of influenza vaccine viruses for rapid response to pandemics Analyzed the data: ML. keywords: avian; experiments; h5n1; human; influenza; pandemic; ppp; research; risk; transmission; viruses cache: cord-001289-qbct63p4.txt plain text: cord-001289-qbct63p4.txt item: #14 of 303 id: cord-001521-l36f1gp7 author: None title: Oral and Poster Manuscripts date: 2011-04-08 words: 183853 flesch: 46 summary: The concept that swine are a mixing-vessel for the reassortment of influenza viruses and for the emergence of pandemic influenza viruses has been re-enforced by the emergence of the recent pandemic. This study was supported by Contract HHSN266200700005C from the National Institute of Allergy and Infectious Diseases, National Institutes of Pigs have been considered as hypothetical 'mixing vessels' facilitating the genesis of pandemic influenza viruses. keywords: age; analysis; animals; antibodies; antibody; antiviral; assay; associated; avian; b viruses; b ⁄; balb ⁄; binding; c virus; c ⁄; cases; cells; challenge; children; control; cross; culture; data; days; detection; disease; dk ⁄; dose; effect; ferrets; figure; following; gene; group; h1n1 influenza; h1n1 pandemic; h1n1 virus; h5n1 infection; h5n1 viruses; h9n2; health; high; hong; hours; human h1n1; human influenza; humans; immunity; infected; infections; influenza antigenic; influenza c; influenza epidemic; influenza infection; influenza influenza; influenza neuraminidase; influenza outbreaks; influenza pandemic; influenza patients; influenza research; influenza samples; influenza season; influenza strains; influenza surveillance; influenza transmission; influenza vaccination; influenza vaccine; influenza virus; isolates; kong ⁄; laboratory; laiv; lg ⁄; like; low; lung; mallard ⁄; mdck; method; mg ⁄; mice; model; mutation; nasal; new; non; novel; number; observed; origin influenza; oseltamivir; patients; pcr; period; pigs; population; positive; post; potential; potsdam ⁄; protection; protein; public; rate; research; resistance; respiratory; response; results; risk; rna; samples; school; seasonal; sensitivity; sequence; serum; severe; specific; specimens; studies; study; subjects; subtype influenza; sw ⁄; swine influenza; swine viruses; system; t ⁄; table; test; time; treatment; type virus; vaccines; values; virus gene; virus infection; virus isolation; virus ns1; virus replication; virus strains; virus titers; virus transmission; virus vaccine; virus ⁄; viruses; wave; years; ⁄ brisbane; ⁄ california; ⁄ genoa; ⁄ h1n1; ⁄ h3n2; ⁄ h5n1; ⁄ hk; ⁄ hok; ⁄ lee; ⁄ leningrad; ⁄ ml; ⁄ netherlands; ⁄ ns1; ⁄ panama; ⁄ pr8; ⁄ vietnam cache: cord-001521-l36f1gp7.txt plain text: cord-001521-l36f1gp7.txt item: #15 of 303 id: cord-001634-mi5gcfcw author: Davis, Mark D M title: Beyond resistance: social factors in the general public response to pandemic influenza date: 2015-04-29 words: 6684 flesch: 42 summary: The research aimed to identify how members of the general public respond to pandemic influenza so that public health communications can be designed to engage with how its audiences respond to risk messages and how they enact hygiene, social isolation and related measures. Using qualitative methods, this paper investigates how members of the general public respond to pandemic influenza and the hygiene, social isolation and other measures proposed by public health. keywords: communications; focus; general; health; infection; influenza; members; pandemic; people; public; research; risk cache: cord-001634-mi5gcfcw.txt plain text: cord-001634-mi5gcfcw.txt item: #16 of 303 id: cord-001654-o2zfilcl author: Laidler, Matthew R. title: Statin Treatment and Mortality: Propensity Score-Matched Analyses of 2007–2008 and 2009–2010 Laboratory-Confirmed Influenza Hospitalizations date: 2015-03-04 words: 4010 flesch: 36 summary: Two studies evaluating statin use during multiple influenza seasons in the decade before the 2009 pandemic found a protective effect on influenza mortality, although 1 of the studies found only a modest (10% reduction in deaths from pneumonia) Nonetheless, we also found a protective effect of statins on death among laboratoryconfirmed influenza patients hospitalized during the 2007-2008 season. keywords: chronic; data; disease; influenza; mortality; pandemic; patients; statin; treatment cache: cord-001654-o2zfilcl.txt plain text: cord-001654-o2zfilcl.txt item: #17 of 303 id: cord-001746-pbahviaz author: Garg, Shikha title: Pneumonia among adults hospitalized with laboratory-confirmed seasonal influenza virus infection—United States, 2005–2008 date: 2015-08-26 words: 4421 flesch: 27 summary: The etiology of influenza-associated pneumonia may include primary influenza pneumonia, secondary bacterial pneumonia, or Pulmonary complications of influenza Rates of pneumonia during influenza epidemics in Seattle Influenza pneumonia: a descriptive study Pulmonary complications of interpandemic influenza A in hospitalized adults Adult hospitalizations for laboratory-positive influenza during the Influenzaassociated pneumonia in children hospitalized with laboratory-confirmed influenza Viral pneumonia in older adults Immunology of the aging lung Physiological changes in respiratory function associated with ageing Risk factors for pneumonia and other lower respiratory tract infections in elderly residents of long-term care facilities Lessons from a nursing home outbreak of influenza A Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices-United States Children with asthma hospitalized with seasonal or pandemic influenza Bacterial pneumonia during the Hong Kong influenza epidemic of 1968-1969 Influenza-associated pediatric mortality in the United States: increase of Staphylococcus aureus coinfection Influenza-associated mortality among children -United States Staphylococcus aureus pneumonia in children in the era of community-acquired methicillin-resistance at Texas Children's Hospital Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season Infectious diseases society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children Updated recommendations for prevention of invasive pneumococcal disease among adults using the 23-valent pneumococcal polysaccharide vaccine (PPSV23) Clinical characteristics and outcomes of H1N1-associated pneumonia among adults in South Korea Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China Pneumonia and respiratory failure from swineorigin influenza A (H1N1) in Mexico Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials Benefit of early treatment with oseltamivir in hospitalized patients with documented 2009 influenza A (H1N1): retrospective cohort study Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations Antiviral agents for the treatment and chemoprophylaxis of influenza -recommendations of the Advisory Committee on Immunization Practices (ACIP) Van Hal SJ. keywords: adults; data; influenza; interpretation; manuscript; patients; pneumonia; review; study cache: cord-001746-pbahviaz.txt plain text: cord-001746-pbahviaz.txt item: #18 of 303 id: cord-001826-av2gxfxy author: Gao, Qian title: A cell-based high-throughput approach to identify inhibitors of influenza A virus date: 2014-07-14 words: 2848 flesch: 40 summary: A reporter system mimicking the process of transcription/replication of influenza virus was constructed by Lutz et al. 7 . Cells were transfected with a reporter system that expressed Firefly luciferase in a response proportional to the infectivity of influenza virus. keywords: assay; cells; gluc; influenza; luciferase; reporter; throughput; virus cache: cord-001826-av2gxfxy.txt plain text: cord-001826-av2gxfxy.txt item: #19 of 303 id: cord-002136-mkl89qkt author: Nunes, Sandro F. title: An ex vivo swine tracheal organ culture for the study of influenza infection date: 2009-12-09 words: 4726 flesch: 39 summary: In this study, we developed a swine tracheal EVOC system for the study of influenza virus infection. The pathogenesis of influenza in humans Infection of human airway epithelium by human and avian strains of influenza A virus H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells Ciliostasis is a key early event during colonization of canine tracheal tissue by Bordetella bronchiseptica Adherence of Bordetella bronchiseptica 276 to porcine trachea maintained in organ culture A human respiratory-tissue organ culture incorporating an air interface Development of rhinovirus study model using organ culture of turbinate mucosa Tracheal organ cultures as a useful tool to study Felid herpesvirus 1 infection in respiratory epithelium Quantification of mRNA encoding cytokines and chemokines and assessment of ciliary function in canine tracheal epithelium during infection with canine respiratory coronavirus (CRCoV) Interaction of pneumolysin-sufficient and -deficient isogenic variants of Streptococcus pneumoniae with human respiratory mucosa Interaction of Bordetella periitussis with human respiratory mucosa in vitro Interaction of Pseudomonas aeruginosa with human respiratory mucosa in vitro In vitro culture of porcine respiratory nasal mucosa explants for studying the interaction of porcine viruses with the respiratory tract In vitro culture of equine respiratory mucosa explants Critical assessment of an in vitro bovine respiratory organ culture system: a model of bovine herpesvirus-1 infection Mutation of the maturase lipoprotein attenuates the virulence of Streptococcus equi to a greater extent than does loss of general lipoprotein lipidation The use of human nasal in vitro cell systems during drug discovery and development The Principles of Humane Experimental Technique New low-viscosity overlay medium for viral plaque assays Universal primer set for the full-length amplification of all influenza A viruses Development of a real-time reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes Localization of swine influenza virus in naturally infected pigs Influenza type A in humans, mammals and birds: determinants of virus virulence, host-range and interspecies transmission Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control Cultures of equine respiratory epithelial cells and organ explants as tools for the study of equine influenza virus infection Intrinsic immunity: a front-line defense against viral attack Defense mechanisms against influenza virus infection in the respiratory tract mucosa Effective mucus clearance is essential for respiratory health Efficient mucociliary transport relies on efficient regulation of ciliary beating keywords: cells; culture; explants; infection; influenza; organ; study; swine; tracheal; virus; viruses cache: cord-002136-mkl89qkt.txt plain text: cord-002136-mkl89qkt.txt item: #20 of 303 id: cord-002137-j5sfiyz8 author: Ward, Kirsten title: Annual influenza vaccination: coverage and attitudes of primary care staff in Australia date: 2010-10-12 words: 3707 flesch: 40 summary: Results Reported influenza vaccination coverage in both 2007 and 2008 was greater than 70%, with GPs reporting higher coverage than PNs in both years. Conclusions Rates of influenza vaccination coverage reported in this study were higher than in previous studies of hospital and institutional HCWs, though it is possible that the study design may have contributed to these higher results. keywords: care; coverage; gps; health; influenza; vaccination; vaccine cache: cord-002137-j5sfiyz8.txt plain text: cord-002137-j5sfiyz8.txt item: #21 of 303 id: cord-002337-8v907g24 author: Lipsitch, Marc title: Viral factors in influenza pandemic risk assessment date: 2016-11-11 words: 18969 flesch: 27 summary: The impact of virus binding and release on transmission fitness using influenza as an example Identification of Stabilizing Mutations in an H5 Hemagglutinin Influenza Virus Protein Economic (ir)rationality in risk analysis Avian influenza shedding patterns in waterfowl: implications for surveillance, environmental transmission, and disease spread Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission Airborne transmission of influenza A/H5N1 virus between ferrets Modelling the species jump: towards assessing the risk of human infection from novel avian influenzas Water-bone transmission of influenza A viruses Fluorescence method for measuring the kinetics of fusion between biological membranes Fluorescence assays to monitor fusion of enveloped viruses Assessing the in vitro fitness of an oseltamivir-resistant seasonal A/ H1N1 influenza strain using a mathematical model Surveillance of wild birds for avian influenza virus The function of the neuraminidase in membrane fusion induced by myxoviruses Serological comparison of antibodies to avian influenza viruses, subtypes H5N2, H6N1, H7N3 and H7N9 between poultry workers and non-poultry workers in Taiwan in 2012 Determination of influenza virus proteins required for genome replication Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets Receptor specificity of influenza A viruses correlates with the agglutination of erythrocytes from different animal species The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase Decoding the distribution of glycan receptors for humanadapted influenza a viruses in ferret respiratory tract Outbreak of variant influenza A (H3N2) virus in the United States Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies Emergence of the virulenceassociated PB2 E627K substitution in a fatal human case of highly pathogenic avian influenza virus A (H7N7) infection as determined by Illumina ultradeep sequencing Mutational landscape and significance across 12 major cancer types Novel Highly Pathogenic Avian A(H5N2) and A(H5N8) Ferrets infected with human influenza viruses often exhibit transient weight loss, transient fever, and sneezing, whereas infection with selected HPAI viruses in this species can lead to pronounced weight loss, sustained fever, lethargy, dyspnea, and neurological complications (Belser et al., 2009 ). keywords: acid; activation; adaptation; avian; binding; et al; ferrets; h5n1; hemagglutinin; host; human; infection; influenza; influenza virus; isolates; mammalian; mutations; pandemic; polymerase; protein; receptor; risk; specificity; strain; studies; traits; transmission; virus; viruses cache: cord-002337-8v907g24.txt plain text: cord-002337-8v907g24.txt item: #22 of 303 id: cord-002407-25cawzi0 author: Nogales, Aitor title: Reverse Genetics Approaches for the Development of Influenza Vaccines date: 2016-12-22 words: 11138 flesch: 36 summary: A virus hemagglutinin viral RNA are important for efficient packaging into budding virions Experimental approaches to study genome packaging of influenza A viruses Plasmid-only rescue of influenza A virus vaccine candidates Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza Attenuated influenza virus vaccines with modified NS1 proteins Efficacy of intranasal administration of a truncated NS1 modified live influenza virus vaccine in swine Attenuation of equine influenza viruses through truncations of the NS1 protein Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes Vaccination of pigs against swine influenza viruses by using an NS1-truncated modified live-virus vaccine Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs Characterization of influenza virus variants with different sizes of the non-structural (NS) genes and their potential as a live influenza vaccine in poultry Development of a dual-protective live-attenuated vaccine against H5N1 and H9N2 avian influenza viruses by modifying the NS1 gene Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus NS1-truncated live-attenuated virus vaccine provides robust protection to aged mice from viral challenge Influenza B virus NS1-truncated mutants: Live-attenuated vaccine approach Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach Development of live-attenuated arenavirus vaccines based on codon deoptimization Live attenuated influenza virus vaccines by computer-aided rational design Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice A replication-incompetent virus possessing an uncleavable hemagglutinin as an influenza vaccine Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity Characterization of a neuraminidase-deficient influenza A virus as a potential gene delivery vector and a live vaccine A novel bivalent vaccine based on a PB2-knockout influenza virus protects mice from pandemic H1N1 and highly pathogenic H5N1 virus challenges A replication-incompetent PB2-knockout influenza A virus vaccine vector Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus An eight-segment swine influenza virus harboring H1 and H3 hemagglutinins is attenuated and protective against H1N1 and H3N2 subtypes in pigs A recombinant influenza virus vaccine expressing the f protein of respiratory syncytial virus To date, three types of influenza virus vaccines are approved by the Food and Drug Administration (FDA) for human use: recombinant viral HA, inactivated virus and live-attenuated viruses [65] [66] keywords: cells; eggs; figure; genetics; genome; iav; ibv; influenza; influenza virus; live; production; proteins; replication; strains; vaccine; virus; viruses cache: cord-002407-25cawzi0.txt plain text: cord-002407-25cawzi0.txt item: #23 of 303 id: cord-002408-bbtslrrt author: Almogy, Gal title: Analysis of Influenza and RSV dynamics in the community using a ‘Local Transmission Zone’ approach date: 2017-02-09 words: 5452 flesch: 46 summary: The results presented here hint at the potential epidemiological importance in examining disease data at the LTZ scale,and the possibility for generating 'maps' of the real-time distribution of pathogens at resolution levels sufficient to guide improved public health policies. Disease signal overlap is a useful index for studying and comparing the intersection of two diseases over a season. keywords: disease; influenza; ltzs; overlap; region; rsv; season cache: cord-002408-bbtslrrt.txt plain text: cord-002408-bbtslrrt.txt item: #24 of 303 id: cord-002438-b8t4a57r author: Cheng, Wei title: Comparison of Influenza Epidemiological and Virological Characteristics between Outpatients and Inpatients in Zhejiang Province, China, March 2011–June 2015 date: 2017-02-22 words: 4847 flesch: 48 summary: Our study demonstrated that the activities of influenza virus, including its subtypes, had a similar temporal pattern between ILI and SARI cases. Currently, the selection of strains for the annual influenza vaccine are primarily 2 of 12 based on the predominant strain of influenza virus detected in influenza-like illness (ILI) keywords: cases; ili; influenza; patients; rate; sari; surveillance; virus cache: cord-002438-b8t4a57r.txt plain text: cord-002438-b8t4a57r.txt item: #25 of 303 id: cord-002852-m4l2l2r1 author: Munyua, Peninah M. title: Detection of influenza A virus in live bird markets in Kenya, 2009–2011 date: 2012-04-19 words: 3993 flesch: 55 summary: Background Surveillance for influenza viruses within live bird markets (LBMs) has been recognized as an effective tool for detecting circulating avian influenza viruses (AIVs). In Sub‐Saharan Africa, limited data exist on AIVs in animal hosts, and in Kenya the presence of influenza virus in animal hosts has not been described. keywords: birds; detection; influenza; markets; poultry; specimens; virus; viruses cache: cord-002852-m4l2l2r1.txt plain text: cord-002852-m4l2l2r1.txt item: #26 of 303 id: cord-002919-6xjm7f29 author: Luo, Haili title: Clinical characteristics from co-infection with avian influenza A H7N9 and Mycoplasma pneumoniae: a case report date: 2018-03-15 words: 2758 flesch: 48 summary: Since the incubation period of MP infection is often as long as 1 to 3 weeks [5] , we speculate that MP may have already existed in our patient's respiratory system at the time when she was infected with avian influenza A H7N9. Early clinical observations indicated a relatively high prevalence of MP respiratory infection in younger children, especially among school-aged children from 5 to 15 years of age [10] . keywords: h7n9; infection; influenza; patient; treatment cache: cord-002919-6xjm7f29.txt plain text: cord-002919-6xjm7f29.txt item: #27 of 303 id: cord-002939-6a3ga6v9 author: Ribeiro, Ana Freitas title: Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009 date: 2018-03-26 words: 4663 flesch: 41 summary: key: cord-002939-6a3ga6v9 authors: Ribeiro, Ana Freitas; Pellini, Alessandra Cristina Guedes; Kitagawa, Beatriz Yuko; Marques, Daniel; Madalosso, Geraldine; Fred, Joao; Albernaz, Ricardo Kerti Mangabeira; Carvalhanas, Telma Regina Marques Pinto; Zanetta, Dirce Maria Trevisan title: Severe influenza A(H1N1)pdm09 in pregnant women and neonatal outcomes, State of Sao Paulo, Brazil, 2009 date: 2018-03-26 journal: PLoS One DOI: 10.1371/journal.pone.0194392 sha: doc_id: 2939 cord_uid: 6a3ga6v9 To investigate the factors associated with death and describe the gestational outcomes in pregnant women with influenza A(H1N1)pdm09, we conducted a case-control study (deaths and recovered) in hospitalized pregnant women with laboratory-confirmed influenza A(H1N1)pdm09 with severe acute respiratory illness (SARI) in the state of São Paulo from June 9 to December 1, 2009. Antiviral treatment was a protective Severe influenza A(H1N1) in pregnant women factor for death when administered within the first 48 hours after the onset of symptoms, OR 0.16 (95% CI 0.05-0.50), and when administered 48 to 72 hours after the onset of symptoms, OR 0.09 (95% CI 0.01-0.87). keywords: cases; controls; death; health; hospitalization; influenza; pandemic; risk; women cache: cord-002939-6a3ga6v9.txt plain text: cord-002939-6a3ga6v9.txt item: #28 of 303 id: cord-002972-ge7qt256 author: Torner, Núria title: Descriptive study of severe hospitalized cases of laboratory-confirmed influenza during five epidemic seasons (2010–2015) date: 2018-04-14 words: 2677 flesch: 38 summary: Predominant influenza type/subtype circulating each season, influenza vaccination policies and coverage, influenza vaccine strain match/mismatch and vaccine effectiveness significantly influence the % of hospitalised influenza cases and CFRs in all age groups, including older age groups. The median age of cases was 61 years (range 0–101 years); 70.5% were unvaccinated; 80.4% received antiviral treatment (in 79.6 and 24% of cases within 48 h after hospital admission and the onset of symptoms, respectively); influenza virus keywords: age; cases; influenza; shclci; surveillance; virus; years cache: cord-002972-ge7qt256.txt plain text: cord-002972-ge7qt256.txt item: #29 of 303 id: cord-003099-a0acr28o author: Koch, R. M. title: The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection date: 2018-07-05 words: 3886 flesch: 34 summary: key: cord-003099-a0acr28o authors: Koch, R. M.; Diavatopoulos, D. A.; Ferwerda, G.; Pickkers, P.; de Jonge, M. I.; Kox, M. title: The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection date: 2018-07-05 journal: Intensive Care Med Exp DOI: 10.1186/s40635-018-0182-5 sha: doc_id: 3099 cord_uid: a0acr28o BACKGROUND: Influenza infections are often complicated by secondary infections, which are associated with high morbidity and mortality, suggesting that influenza profoundly influences the immune response towards a subsequent pathogenic challenge. Herein, we investigated whether influenza infection results in an enhanced or suppressed innate immune response upon a secondary challenge with bacterial lipopolysaccharide (LPS) in either the acute or the recovery phase of infection. keywords: data; days; infection; influenza; lps; lung; mice; response cache: cord-003099-a0acr28o.txt plain text: cord-003099-a0acr28o.txt item: #30 of 303 id: cord-003122-a3f4l6iu author: Dou, Dan title: Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement date: 2018-07-20 words: 10292 flesch: 26 summary: Isolation and characterization of the signal recognition particle receptor Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway Substratespecific translocational attenuation during ER stress defines a pre-emptive quality control pathway Solving the membrane protein folding problem X-ray structure of a protein-conducting channel Molecular code for transmembrane-helix recognition by the Sec61 translocon Polar residues and their positional context dictate the transmembrane domain interactions of influenza a neuraminidases Protein translocation across the rough endoplasmic reticulum The cotranslational maturation program for the type II membrane glycoprotein influenza neuraminidase N-linked carbohydrates act as lumenal maturation and quality control protein tags The number and location of glycans on influenza hemagglutinin determine folding and association with calnexin and calreticulin Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds Steps in maturation of influenza A virus neuraminidase Assembly of subtype 1 influenza neuraminidase is driven by both the transmembrane and head domains The influenza virus neuraminidase protein transmembrane and head domains have coevolved Influenza A viral replication is blocked by inhibition of the inositolrequiring enzyme 1 (IRE1) stress pathway Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-beta release in lung epithelial cells Influenza a virus host shutoff disables antiviral stress-induced translation arrest Real-time RT-qPCR assay for the analysis of human influenza A virus transcription and replication dynamics Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA Translational regulation of viral secretory proteins by the 5' coding regions and a viral RNA-binding protein The signal sequence coding region promotes nuclear export of mRNA The NS1 protein from influenza virus stimulates translation initiation by enhancing ribosome recruitment to mRNAs Major contribution of the RNA-binding domain of NS1 in the pathogenicity and replication potential of an avian H7N1 influenza virus in chickens Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus Influenza virus NS1 protein stimulates translation of the M1 protein Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs Influenza viruses cause hemolysis and fusion of cells Interaction of influenza virus hemagglutinin with target membrane lipids is a key step in virus-induced hemolysis and fusion at pH 5.2 Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium Proteolytic activation of the 1918 influenza virus hemagglutinin Cleavage of influenza a virus hemagglutinin in human respiratory epithelium is cell associated and sensitive to exogenous antiproteases Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts Lipid rafts as a membrane-organizing principle Influenza virus assembly and budding Association of influenza virus proteins with membrane rafts Mutations at palmitylation sites of the influenza virus hemagglutinin affect virus formation Acylation-mediated membrane anchoring of avian influenza virus hemagglutinin is essential for fusion pore formation and virus infectivity S acylation of the hemagglutinin of influenza viruses: mass spectrometry reveals site-specific attachment of stearic acid to a transmembrane cysteine Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion Role of transmembrane domain and cytoplasmic tail amino acid sequences of influenza a virus neuraminidase in raft association and virus budding Influenza virus M2 protein mediates ESCRT-independent membrane scission Influenza virus assembly: effect of influenza virus glycoproteins on the membrane association of M1 protein Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins Identification of the domains of the influenza A virus M1 matrix protein required for NP binding, oligomerization and incorporation into virions Membrane curvature in cell biology: an integration of molecular mechanisms Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles Formation of virus-like particles from human cell lines exclusively expressing influenza neuraminidase Budding capability of the influenza virus neuraminidase can be modulated by tetherin Structural analysis of the roles of influenza A virus membrane-associated proteins in assembly and morphology influenza A virus ribonucleoproteins Transport of incoming influenza virus nucleocapsids into the nucleus Nuclear import of microinjected influenza virus ribonucleoproteins Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import The NPI-1/NPI-3 (karyopherin alpha) binding site on the influenza a virus nucleoprotein NP is a nonconventional nuclear localization signal An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein Ultrastructural analysis of the nuclear localization sequences on influenza A ribonucleoprotein complexes Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis Influenza a virus assembly intermediates fuse in the cytoplasm Analysis of IAV replication and co-infection dynamics by a versatile RNA viral genome labeling method Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus The RNA polymerase of influenza a virus: mechanisms of viral transcription and replication Structural insights into RNA synthesis by the influenza virus transcription-replication machine Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication Internal initiation of influenza virus replication of viral RNA and complementary RNA in vitro Structural insight into cap-snatching and RNA synthesis by influenza polymerase A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription Association of the influenza A virus RNAdependent RNA polymerase with cellular RNA polymerase II RNA-free and ribonucleoproteinassociated influenza virus polymerases directly bind the serine-5-phosphorylated carboxyl-terminal domain of host RNA polymerase II Structural basis of an essential interaction between influenza polymerase and Pol II CTD The structural basis for cap binding by influenza virus polymerase subunit PB2 keywords: binding; cell; figure; hemagglutinin; host; iavs; influenza; influenza virus; membrane; neuraminidase; nuclear; polymerase; protein; replication; rna; viral; virus; viruses cache: cord-003122-a3f4l6iu.txt plain text: cord-003122-a3f4l6iu.txt item: #31 of 303 id: cord-003232-nquw7qga author: Kuchipudi, Suresh V. title: Novel Flu Viruses in Bats and Cattle: “Pushing the Envelope” of Influenza Infection date: 2018-08-06 words: 3855 flesch: 38 summary: A virus polymerase is a site for adaptive changes during experimental evolution in bat cells Differences in influenza virus receptors in chickens and ducks: Implications for interspecies transmission Endocytosis of influenza viruses. The genetic diversity of influenza viruses is ever increasing with more novel influenza subtypes being discovered periodically. keywords: bat; bats; cattle; host; human; iavs; influenza; virus; viruses cache: cord-003232-nquw7qga.txt plain text: cord-003232-nquw7qga.txt item: #32 of 303 id: cord-003302-vxk7uqlc author: Fedson, David S title: Influenza, evolution, and the next pandemic date: 2018-10-03 words: 6390 flesch: 40 summary: Two recent studies of influenza virus infection and endotoxemia in mice have shown that survival is better before puberty than after puberty. The role of oxidative stress in influenza virus infection Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection The lung microvascular endothelium as a therapeutic target in severe influenza Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms Perpetual change: autophagy, the endothelium, and response to vascular injury Autophagy induction regulates influenza virus replication in a time-dependent manner Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection Activation of autophagy is involved in the protective effect of 17b-oestradiol on endotoxaemia-induced multiple organ dysfunction in ovariectomized rats Disease tolerance as a defense strategy Disease tolerance and immunity in host protection against infection Unravelling the networks dictating host resistance versus tolerance during pulmonary infections KM ES 1 Jamieson AM. keywords: adults; children; host; illness; infection; influenza; mice; mortality; pandemic; response; virus cache: cord-003302-vxk7uqlc.txt plain text: cord-003302-vxk7uqlc.txt item: #33 of 303 id: cord-003466-599x0euj author: Nickol, Michaela E. title: A year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918–1919 date: 2019-02-06 words: 5774 flesch: 42 summary: The emergence of pandemic influenza viruses Summary report on the Asian influenza epidemic in Japan 1957 Public health and medical responses to the 1957-58 influenza pandemic Global mortality impact of the 1957-1959 influenza pandemic Estimated global mortality associated with the first 12 months of 2009 pandemic influenza a H1N1 virus circulation: a modelling study Antigenic similarity of influenza a (H1N1) viruses from epidemics in 1977--1978 to The 1918 influenza pandemic: lessons for 2009 and the future The Spanish flu--part II: the second and third wave Paths of infection: the first world war and the origins of the 1918 influenza pandemic The Spanish flu--part Analyses of influenza virus genome sequences also suggest that the initial entry of the 1918 precursor virus into human circulation began in 1915 and did not appear to have jumped directly from an avian source [4, 38, 39] . keywords: health; infections; influenza; influenza virus; mortality; pandemic; spread; virus; viruses; wave; years cache: cord-003466-599x0euj.txt plain text: cord-003466-599x0euj.txt item: #34 of 303 id: cord-003523-byxuruk1 author: Fritsch, Annemarie title: Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014 date: 2019-03-07 words: 4296 flesch: 44 summary: Influenza Other Respir Viruses Study of influenza C virus infection in France Epidemiological information regarding the periodic epidemics of influenza C virus in Japan (1996-2013) and the seroprevalence of antibodies to different antigenic groups Bericht zur Epidemiologie der Influenza in Deutschland Saison on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions Diagnostic approach for the differentiation of the pandemic influenza A(H1N1)v virus from recent human influenza viruses by realtime PCR Detection and quantification of influenza C virus in pediatric respiratory specimens by real-time PCR and comparison with infectious viral counts Influenza C virus hemagglutinin: comparison with influenza A and B virus hemagglutinins Age distribution of the antibody to type C influenza virus Detection of influenza C virus by a real-time RT-PCR assay. key: cord-003523-byxuruk1 authors: Fritsch, Annemarie; Schweiger, Brunhilde; Biere, Barbara title: Influenza C virus in pre-school children with respiratory infections: retrospective analysis of data from the national influenza surveillance system in Germany, 2012 to 2014 date: 2019-03-07 journal: Euro Surveill DOI: 10.2807/1560-7917.es.2019.24.10.1800174 sha: doc_id: 3523 cord_uid: byxuruk1 INTRODUCTION: keywords: children; detection; infection; influenza; patients; samples; sequences; virus; viruses cache: cord-003523-byxuruk1.txt plain text: cord-003523-byxuruk1.txt item: #35 of 303 id: cord-003567-h8uq5z8b author: Crank, Michelle C title: Preparing for the Next Influenza Pandemic: The Development of a Universal Influenza Vaccine date: 2019-04-15 words: 1559 flesch: 27 summary: Updating the accounts: global mortality of the 1918-1920 Spanish influenza pandemic Influenza vaccines: good, but we can do better Making universal influenza vaccines: lessons from the 1918 pandemic Can we predict the next influenza pandemics? Antibody determinants of influenza immunity The way forward: potentiating protective immunity to novel and pandemic influenza through engagement of memory CD4 T cells Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens Dynamic perspectives on the search for a universal influenza vaccine Universal influenza vaccine approaches employing full-length or head-only HA proteins Universal influenza virus vaccines that target the conserved hemagglutinin stalk and conserved sites in the head domain The role of M2e in the development of universal influenza vaccines Neuraminidase, the forgotten surface antigen, emerges as an influenza vaccine target for broadened protection How live attenuated vaccines can Inform the development of broadly cross-protective influenza vaccines New vaccine design and delivery technologies Influenza immunization in low-and middle-income countries: preparing for next-generation influenza vaccines Novel vaccine technologies: essential components of an adequate response to emerging viral diseases Emerging viral diseases from a vaccinology perspective: preparing for the next pandemic Advances in antiviral vaccine development A universal influenza vaccine: the strategic plan for the National Institute of Allergy and Infectious Diseases Historical estimates of world population On the doctrine of original antigenic sin Pandemic risk: how large are the expected losses? Vaccine development in the twenty-first century: changing paradigms for elusive viruses Improving the characterization of and expanding the reagents for these models would not only benefit influenza vaccine development but would also provide answers to immunological questions relevant to other respiratory virus infections and emerging infectious diseases in general. keywords: immunity; influenza; pandemic; universal; vaccine cache: cord-003567-h8uq5z8b.txt plain text: cord-003567-h8uq5z8b.txt item: #36 of 303 id: cord-003571-upogtny6 author: Viboud, Cécile title: The 1918 Influenza Pandemic: Looking Back, Looking Forward date: 2018-10-20 words: 3834 flesch: 34 summary: Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus Preliminary statistics of the influenza epidemic Influenza transmission in households during the 1918 pandemic The Great Influenza: The Story of the Deadliest Pandemic in History Origins of the 1918 pandemic: revisiting the swine mixing vessel hypothesis Loose ends in the epidemiology of the 1918 pandemic: explaining the extreme mortality risk in young adults Age-specific excess mortality patterns during the 1918-1920 influenza pandemic in Madrid, Spain Influenza in New Zealand before 1918: a preliminary report Investigating the legacy of 1918 pandemic on age-related seroepidemiology and immune responses to subsequent influenza A(H1N1) viruses through a structural equation model The 1918-1919 influenza pandemic in Portugal: a regional analysis of death impact Spatiotemporal patterns and diffusion of the 1918 influenza pandemic in British India Reassessing the global mortality burden of the 1918 influenza pandemic Social class and excess mortality in Sweden during the 1918 influenza pandemic Natality decline and spatial variation in excess death rates during the 1918-1920 influenza pandemic in Arizona, United States Short-term birth sequelae of the 1918-1920 influenza pandemic in the United States: state-level analysis Readiness for responding to a severe pandemic 100 years after 1918 Universal influenza vaccines: progress in achieving broad cross-protection in vivo Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting Re-examining the evidence regarding circulation of a human H1 influenza virus immediately prior to the 1918 Spanish flu Age-and sex-specific mortality associated with the 1918-1919 influenza pandemic in Kentucky Epidemiological evidence of an early wave of the 1918 influenza pandemic in New York City Influenza epidemics in Iceland over 9 decades: changes in timing and synchrony with the United States and Europe Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysis Global mortality estimates for the 2009 influenza pandemic from the GLaMOR project: a modeling study Natality decline and miscarriages associated with the 1918 influenza pandemic: the Scandinavian and United States experiences Transmissibility and geographic spread of the 1889 influenza pandemic Age-specific excess mortality patterns and transmissibility during the 1889-1890 influenza pandemic in Madrid, Spain Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China Use of serological surveys to generate key insights into the changing global landscape of infectious disease The ghost of influenza past and the hunt for a universal vaccine This article does not necessarily represent the views of the National Institutes of Health or the US government. They identified several age breakpoints in pandemic mortality that were suggestive of the cycling of different influenza strains between the mid-19th century and the 1918 pandemic. keywords: age; data; epidemiology; influenza; mortality; natality; pandemic; virus cache: cord-003571-upogtny6.txt plain text: cord-003571-upogtny6.txt item: #37 of 303 id: cord-003598-m2fsrwvw author: Elbahesh, Husni title: Response Modifiers: Tweaking the Immune Response Against Influenza A Virus date: 2019-04-12 words: 4176 flesch: 22 summary: Regulatory roles of c-jun in H5N1 influenza virus replication and host inflammation Inhibition of p38 mitogen-activated protein kinase impairs influenza virus-induced primary and secondary host gene responses and protects mice from lethal H5N1 infection The MEK-inhibitor CI-1040 displays a broad anti-influenza virus activity in vitro and provides a prolonged treatment window compared to standard of care in vivo The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice PAR1 contributes to influenza A virus pathogenicity in mice Increased survival after gemfibrozil treatment of severe mouse influenza TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection Peroxisome proliferator-activated receptor and AMP-activated protein kinase agonists protect against lethal influenza virus challenge in mice Treating influenza infection, from now and into the future Angiopoietinlike 4 interacts with matrix proteins to modulate wound healing Role of Angptl4 in vascular permeability and inflammation H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression Relevance of signaling molecules for apoptosis induction on influenza A virus replication Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice Innate immune responses to influenza A H5N1: friend or foe? Repurposing host-based therapeutics to control coronavirus and influenza virus Repurposing of drugs as novel influenza inhibitors from clinical gene expression infection signatures Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction Network-guided discovery of influenza virus replication host factors Cellular networks involved in the influenza virus life cycle Genetic screens for the control of influenza virus replication: from meta-analysis to drug discovery Meta-and orthogonal integration of influenza OMICs data defines a role for UBR4 in virus budding The magnitude of the T cell response to a clinically significant dose of influenza virus is regulated by TRAIL Pathogenic potential of interferon alphabeta in acute influenza infection Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins keywords: cells; host; iav; immune; infections; influenza; mice; protein; replication; responses; virus cache: cord-003598-m2fsrwvw.txt plain text: cord-003598-m2fsrwvw.txt item: #38 of 303 id: cord-003701-i70ztypg author: Chow, Eric J. title: Influenza virus-related critical illness: prevention, diagnosis, treatment date: 2019-06-12 words: 6873 flesch: 16 summary: • Enterically administered oseltamivir is recommended for influenza patients except for those with contraindications (e.g., gastric stasis, ileus, malabsorption). In particular, a large pooled individual patient-level meta-analysis of observational studies from 38 countries identified a 38% reduction in risk of mortality in critically ill adults and those aged ≥ 16 years old when comparing early NAI treatment (< 48 h) with later treatment (> 48 h), and a 69% reduction in mortality risk between influenza patients receiving early NAI treatment and those who did not receive NAIs [72] . keywords: adults; infection; influenza; mortality; oseltamivir; patients; risk; studies; study; treatment; virus cache: cord-003701-i70ztypg.txt plain text: cord-003701-i70ztypg.txt item: #39 of 303 id: cord-003870-hr99dwi7 author: Clohisey, Sara title: Host susceptibility to severe influenza A virus infection date: 2019-09-05 words: 6002 flesch: 38 summary: IFITM3 has also been recently shown to have a protective effect on the heart during severe IAV infection. A more recent study of Han Chinese individuals that looked at several genes confirmed an association between CD55 rs2564978 T/T and death from severe IAV infection [72] . keywords: associated; cell; disease; gene; host; iav; infection; influenza; pandemic; risk; study; susceptibility; virus cache: cord-003870-hr99dwi7.txt plain text: cord-003870-hr99dwi7.txt item: #40 of 303 id: cord-003898-y6zpvw84 author: Tan, Kai Sen title: RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications date: 2019-08-27 words: 7697 flesch: 39 summary: Hence, production of factors such as STAT1 [28] by the hNECs is also crucial in ensuring appropriate regulation of IFNγ-mediated expression of influenza response genes to modulate inflammation and to minimize damage. At later time points, the number of gene expression changes increased substantially, with upregulation of 704 and 1080 genes, and downregulation of 217 and 758 genes at 24 and 48 hpi, respectively. keywords: analysis; cells; changes; epithelium; expression; genes; hnecs; hpi; infection; influenza; nasal; responses; rnaseq; time; virus cache: cord-003898-y6zpvw84.txt plain text: cord-003898-y6zpvw84.txt item: #41 of 303 id: cord-004060-nxw5k9y1 author: Zhang, Yewu title: Spatiotemporal Analysis of Influenza in China, 2005–2018 date: 2019-12-23 words: 5551 flesch: 41 summary: The relative risks of the 14-year study period, holding the covariates and spatial risk constant, were calculated by exponentiating the marginal first-order random walk-correlated time term (γ 1j ) in the spatiotemporal models of influenza risk with and without covariates. This study aims to describe an accurate spatiotemporal pattern of influenza at the prefecture level and explore the risk factors associated with influenza incidence risk in mainland China from 2005 to 2018. keywords: analysis; areas; china; incidence; increase; influenza; interaction; model; risk; study; term; time cache: cord-004060-nxw5k9y1.txt plain text: cord-004060-nxw5k9y1.txt item: #42 of 303 id: cord-004280-c470nlie author: Coleman, Kristen K. title: Airborne Influenza A Virus Exposure in an Elementary School date: 2020-02-05 words: 4124 flesch: 33 summary: Our study represents the first identification and quantification of airborne influenza virus in an elementary school, and the results suggest that airborne IAV has the potential to circulate in schools during influenza season, in large enough doses known to cause infection. Although airborne influenza virus has been detected in select indoor settings 37, 38, 44, [61] keywords: air; densities; iav; influenza; particles; rna; school; student; transmission; virus cache: cord-004280-c470nlie.txt plain text: cord-004280-c470nlie.txt item: #43 of 303 id: cord-004348-4jdn4kw6 author: Chen, Juine-Ruey title: Better influenza vaccines: an industry perspective date: 2020-02-14 words: 6907 flesch: 30 summary: A randomized double-blind placebo-controlled trial Modest waning of influenza vaccine efficacy and antibody titers during the 2007-2008 influenza season Intraseason waning of influenza vaccine protection: evidence from the US influenza vaccine effectiveness network WHO preferred product characteristics for next generation influenza vaccines Two escape mechanisms of influenza a virus to a broadly neutralizing stalk-binding antibody How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin Contribution of antibody production against neuraminidase to the protection afforded by influenza vaccines Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Not applicable. Key Facts About Influenza (Flu) 2019 Available from Antibody response to influenza vaccination in the elderly: a quantitative review Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices-United States Prevention of antigenically drifted influenza by inactivated and live attenuated vaccines Quadrivalent influenza vaccine: a new opportunity to reduce the influenza burden Age Group (Pediatric and Adult), and Route of Administration (Injection and Nasal Spray): Global Opportunity Analysis and Industry Forecast The 2015 global production capacity of seasonal and pandemic influenza vaccine Addendum to the recommended composition of influenza virus vaccines for use in the 2019-2020 northern hemisphere influenza season 2019 Lessons from pandemic influenza a(H1N1): the research-based vaccine industry's perspective Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains Molecular changes associated with adaptation of human influenza a virus in embryonated chicken eggs Evolving complexities of influenza virus and its receptors The role of receptor binding specificity in interspecies transmission of influenza viruses Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children Live attenuated influenza vaccine in children induces B-cell responses in tonsils Influenza vaccine effectiveness against 2009 pandemic influenza a(H1N1) virus differed by vaccine type during 2013-2014 in the United States Intranasal influenza vaccine: why does Canada have different recommendations from the USA on its use? keywords: antigenic; cell; conserved; egg; h1n1; human; immunity; influenza; protection; response; strains; vaccine; virus; viruses cache: cord-004348-4jdn4kw6.txt plain text: cord-004348-4jdn4kw6.txt item: #44 of 303 id: cord-004638-ijncfuxi author: Wang, Yuheng title: Vaccination coverage with the pneumococcal and influenza vaccine among persons with chronic diseases in Shanghai, China, 2017 date: 2020-03-19 words: 4381 flesch: 37 summary: Influenza vaccination coverage was 0.3, 0.5 and 0.9% for those with 1, 2, or 3 conditions (p < 0.001). Influenza vaccination coverage was comparatively low across all districts, ranging from 0.1% in Fengxian to 0.8% in Xuhui. keywords: chronic; coverage; disease; influenza; patients; shanghai; vaccination; vaccine cache: cord-004638-ijncfuxi.txt plain text: cord-004638-ijncfuxi.txt item: #45 of 303 id: cord-005081-kxrzv16n author: Kiselev, O. I. title: Progress in the development of pandemic influenza vaccines and their production technologies date: 2010-11-12 words: 7266 flesch: 42 summary: The state-of-the-art technologies provide safety not only at the laboratories where vaccine viruses are constructed but also make the production process wholly safe. The main task of protecting the population against influenza pandemics requires state-of-the-art approaches to the construction of influenza vaccines to be based on reassortment and genetic engineering techniques, including the analysis of primary structures of influenza viral genes, synthesis and cloning of the main viral genes, reverse genetics techniques, and banks of plasmids bearing basic viral genes. keywords: antigens; cells; influenza; influenza vaccines; influenza virus; obtaining; pandemic; production; protein; strains; technologies; vaccines; vectors; virus; viruses; years cache: cord-005081-kxrzv16n.txt plain text: cord-005081-kxrzv16n.txt item: #46 of 303 id: cord-005314-p7hzoz5d author: Wong, Li Ping title: Knowledge and Attitudes in Regard to Pandemic Influenza A(H1N1) in a Multiethnic Community of Malaysia date: 2010-09-11 words: 3622 flesch: 46 summary: Despite widespread information about the control measures in response to the emergence of pandemic influenza A(H1N1), in particular, near one third of the study participants (including a majority of those that believed A(H1N1) infection is often deadly) did not fear being in contact with people with influenza symptoms, and approximately 50% were not afraid to be in contact with people who had just returned from overseas. In both the SARS and H5N1 avian influenza outbreaks, public fear and level of distress was associated with perceptions and knowledge [8, 13] . keywords: a(h1n1; infection; influenza; knowledge; public; respondents; study cache: cord-005314-p7hzoz5d.txt plain text: cord-005314-p7hzoz5d.txt item: #47 of 303 id: cord-006089-08g206kf author: Stevens, James title: Glycan microarray technologies: tools to survey host specificity of influenza viruses date: 2006-10-02 words: 6098 flesch: 28 summary: (Reply) Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO Molecular basis for the generation in pigs of influenza A viruses with pandemic potential Human and avian influenza viruses target different cell types in cultures of human airway epithelium Avian flu: influenza virus receptors in the human airway Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity H5N1 virus attachment to lower respiratory tract Differences between influenza virus receptors on target cells of duck and chicken Quail carry sialic acid receptors compatible with binding of avian and human influenza viruses Avian H5N1 influenza in cats Avian influenza H5N1 in tigers and leopards Bird flu spreads among Java's pigs Feline friend or potential foe? Substituted sialic acid prosthetic groups as determinants of viral hemagglutination Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin The hemagglutinins of the human influenza viruses A and B recognize different receptor microdomains Receptor binding properties of human and animal H1 influenza virus isolates A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity A solid-phase enzyme-linked assay for influenza virus receptorbinding activity Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography Cell surface biology mediated by low affinity multivalent protein-glycan interactions Synthesis of polymeric neoglycoconjugates based on N-substituted polyacrylamides Specification of receptorbinding phenotypes of influenza virus isolates from different hosts using synthetic sialylglycopolymers: non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6′-sialyl(N-acetyllactosamine) Avian influenza This Perspective article discusses existing methods that are used to study influenza virus receptor specificity and then introduces recently described glycan microarray technologies that are used to study the glycan-binding properties of several influenza virus HAs, including a current H5 HA. Methods to assess HA receptor specificity One important aspect of surveillance is to determine whether a particular avian influenza virus strain is adapting to human receptors. keywords: avian; binding; cells; glycan; h5n1; human; influenza; receptor; specificity; virus; viruses cache: cord-006089-08g206kf.txt plain text: cord-006089-08g206kf.txt item: #48 of 303 id: cord-006172-ndmf5ekp author: Akins, Paul Taylor title: H1N1 Encephalitis with Malignant Edema and Review of Neurologic Complications from Influenza date: 2010-09-02 words: 5008 flesch: 35 summary: 1918 influenza, encephalitis lethargica, parkinsonism Neuropathogenesis of influenza virus infection in mice PCR on cerebrospinal fluid to show influenza associated acute encephalopathy or encephalitis Detection of influenza virus RNA by reverse-transcription-PCR and proinflammatory cytokines in influenza-associated encephalopathy Acute encephalopathy associated with influenza A virus infection Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza Acute encephalopathy associated with influenza A infection in adults Systemic cytokine responses in patients with influenza-associated encephalopathy Cytokine profiles induced by the novel swine origin Influenza A/H1N1 virus: Implications for treatment strategies Tumor necrosis factor-a, Interleukin-1b, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures. The emerging hypothesis about acute neurologic complications of seasonal influenza is that the immune response triggered by influenza virus infection of the respiratory tract plays a prominent role in the pathogenesis of neurological manifestations. keywords: acute; brain; case; complications; csf; edema; encephalitis; encephalopathy; h1n1; infection; influenza; patients; virus cache: cord-006172-ndmf5ekp.txt plain text: cord-006172-ndmf5ekp.txt item: #49 of 303 id: cord-006252-cbelsymu author: Gross, Peter A. title: Current Recommendations for the Prevention and Treatment of Influenza in the Older Population date: 2012-11-18 words: 7667 flesch: 45 summary: Experiences in the use and efficacy of inactivated influenza vaccine in nursing homes Impact of epidemic type A influenza in a defined adult population Underestimation of the role of pneumonia and influenza in causing excess mortality Effectiveness of inactivated influenza vaccine among non-institutionalized elderly persons Resistance of influenza A virus to amantadine and rimantadine: results of one decade of surveillance Antibody induced by influenza vaccines in the elderly: a review of the literature Influenza vaccination in community elderly: a controlled trial of postcard reminders Clinical manifestations and consequences of influenza Antimicrobial agents: antiviral agents Immunizations for health care workers and patients in hospitals Survey of underlying conditions of persons hospitalized with acute respiratory disease during influenza epidemics in Houston Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly The effect of split virus influenza vaccination on theophylline pharmacokinetics Association of in fluenza immunization with reduction in mortality in an elderly References Experiences in the use and efficacy of inactivated influenza vaccine in nursing homes Impact of epidemic type A influenza in a defined adult population Underestimation of the role of pneumonia and influenza in causing excess mortality Effectiveness of inactivated influenza vaccine among non-institutionalized elderly persons Resistance of influenza A virus to amantadine and rimantadine: results of one decade of surveillance Antibody induced by influenza vaccines in the elderly: a review of the literature Influenza vaccination in community elderly: a controlled trial of postcard reminders Clinical manifestations and consequences of influenza Antimicrobial agents: antiviral agents Immunizations for health care workers and patients in hospitals Survey of underlying conditions of persons hospitalized with acute respiratory disease during influenza epidemics in Houston Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly The effect of split virus influenza vaccination on theophylline pharmacokinetics Association of in fluenza immunization with reduction in mortality in an elderly population: a prospective study Immunization of elderly people with high doses of influenza vaccine Relation of chronic disease and immune response to influenza vaccine in the elderly Immunization of elderly people with two doses of influenza vaccine Effect of influenza vaccine on serum anticonvulsant concentrations And addendum clarification Economical laboratory support system for influenza virus surveillance Prevention and control of influenza: role of vaccine Economic impact of influenza: the individual's perspective Prevention and Treatment of Influenza population: a prospective study Immunization of elderly people with high doses of influenza vaccine Relation of chronic disease and immune response to influenza vaccine in the elderly Immunization of elderly people with two doses of influenza vaccine Effect of influenza vaccine on serum anticonvulsant concentrations Epidemiologic implications of changes in the influenza virus genome T-cell recognition of influenza viral antigens Impact of influenza epidemic on mortality in the United States from Frequency of adverse reactions to influenza vaccine in the elderly Frequency of adverse reactions after influenza vaccine Effects of influenza virus vaccine on hepatic drug metabolism keywords: amantadine; care; influenza; influenza vaccine; influenza virus; persons; risk; vaccine; virus cache: cord-006252-cbelsymu.txt plain text: cord-006252-cbelsymu.txt item: #50 of 303 id: cord-006345-03kqeed3 author: Takayama, Koji title: Clinical features of the 2009 swine-origin influenza A (H1N1) outbreak in Japan date: 2010-12-21 words: 2743 flesch: 49 summary: When influenza viruses are circulating in a community, a positive test indicates that the specimen is likely to be infected with the influenza virus. World now at the start of 2009 influenza pandemic Flash report of influenza virus in Japan, 2009/10 season (seasonal ? keywords: h1n1; influenza; pandemic; patients; ridt; virus cache: cord-006345-03kqeed3.txt plain text: cord-006345-03kqeed3.txt item: #51 of 303 id: cord-006362-7d5wzb7p author: van Riel, Debby title: Influenza pathogenicity during pregnancy in women and animal models date: 2016-07-07 words: 5042 flesch: 34 summary: A virus subtype H1N1 The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation Association between severe pandemic 2009 influenza A (H1N1) virus infection and immunoglobulin G(2) subclass deficiency Imbalanced anti-H1N1 immunoglobulin subclasses and dysregulated cytokines in hospitalized pregnant women with 2009 H1N1 influenza and pneumonia in Shenyang, China pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature Perinatal outcomes after maternal 2009/ H1N1 infection: national cohort study Clinical features and risk factors for severe and critical pregnant women with 2009 pandemic H1N1 influenza infection in China Influenza and congenital anomalies: a systematic review and meta-analysis Transplacental passage of influenza A/ Bangkok (H3N2) mimicking amniotic fluid infection syndrome High rate of chronic villitis in placentas of pregnancies complicated by influenza A/H1N1 infection Fatal influenzal pneumonia in pregnancy: failure to demonstrate transplacental transmission of influenza virus Influenza, hyperthermia, and congenital malformation Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice The 2009 pandemic H1N1 influenza virus is more pathogenic in pregnant mice than seasonal H1N1 influenza virus Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden, in pregnant mice Highly pathogenic avian influenza H5N1 virus could partly be evacuated by pregnant BALB/c mouse during abortion or preterm delivery Association of foetal wastage with influenza infection during ferret pregnancy The pregnant guinea-pig as a model for studying influenza virus infection in utero: infection of foetal tissues in organ culture and in vivo Pathology of human influenza revisited The influence of experimental infection of gilts with swine H1N2 influenza A virus during the second month of gestation on the course of pregnancy, reproduction parameters and clinical status Pregnancy outcome and clinical status of gilts following experimental infection by H1N2, H3N2 and H1N1pdm09 influenza [37, 38] which largely determine the cell tropism of influenza viruses within the respiratory tract. keywords: cells; h1n1; iav; infection; influenza; mice; pandemic; pregnancy; virus; women cache: cord-006362-7d5wzb7p.txt plain text: cord-006362-7d5wzb7p.txt item: #52 of 303 id: cord-006517-845w9r6l author: Lalueza, A. title: Impact of severe hematological abnormalities in the outcome of hospitalized patients with influenza virus infection date: 2017-05-13 words: 4071 flesch: 41 summary: Although hematological abnormalities have been described among patients with influenza virus infection, little is known about their impact on the outcome of the patients. This was an observational retrospective study including all adult patients with diagnosis of influenza virus infection hospitalized from January to May 2016 in our institution. keywords: abnormalities; cytopenias; group; infection; influenza; outcome; patients; virus cache: cord-006517-845w9r6l.txt plain text: cord-006517-845w9r6l.txt item: #53 of 303 id: cord-007294-qeb2r08t author: EDMONDSON, WILLIAM P. title: A COMPARISON OF SUBCUTANEOUS, NASAL, AND COMBINED INFLUENZA VACCINATION. II. PROTECTION AGAINST NATURAL CHALLENGE(1)(2) date: 1971-06-17 words: 2256 flesch: 40 summary: Based on a net Influenza rates: Influenza illness rates in the control and spray vaccine groups were 14.7 and 12.2/100, respectively (table 3) . These high rates contrast with total influenza illness rates of 1.9/100 and 4.7/100 for the gun and combined groups, respectively. keywords: employees; illness; influenza; rates; vaccine cache: cord-007294-qeb2r08t.txt plain text: cord-007294-qeb2r08t.txt item: #54 of 303 id: cord-007575-5ekgabx5 author: Luby, James P. title: Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses date: 2016-01-14 words: 12010 flesch: 36 summary: Clinically, the patient with influenza virus pneumonia has the sudden onset off ever, prostration, and myalgias followed shortly by dyspnea. Influenza virus pneumonia occurred during hospitalization. keywords: adults; cases; cmv; diffuse; disease; evidence; infection; infiltrates; influenza; lung; mycoplasma; patients; pneumonia; suprainfection; therapy; tract; varicella; virus; viruses cache: cord-007575-5ekgabx5.txt plain text: cord-007575-5ekgabx5.txt item: #55 of 303 id: cord-007583-owxcokge author: Kohn, William G. title: Emerging and re-emerging infectious diseases: Be prepared date: 2014-12-26 words: 1412 flesch: 42 summary: When considering how to apply infection control practices to emerging infectious diseases, it might be best to consider the Boy/Girl Scout motto: Be prepared. Preparation would be a daunting task if each agent required a special set of infection control practices, particularly when infected patients can be asymptomatic or unaware they are infected. keywords: control; h1n1; health; infection; influenza cache: cord-007583-owxcokge.txt plain text: cord-007583-owxcokge.txt item: #56 of 303 id: cord-007681-vhghhvnu author: Schwartz, Benjamin title: Prioritization of Pandemic Influenza Vaccine: Rationale and Strategy for Decision Making date: 2009-06-15 words: 5049 flesch: 26 summary: The time required to develop, license, and manufacture pandemic influenza vaccine is also an important variable. Because of the uncertainties about the severity and epidemiology of the next pandemic, vaccine supply, and the best approach to using vaccine to reduce health, societal and economic impacts, there is no scientific method to define the optimal use of pandemic influenza vaccine. keywords: groups; influenza; pandemic; population; prioritization; public; risk; vaccination; vaccine cache: cord-007681-vhghhvnu.txt plain text: cord-007681-vhghhvnu.txt item: #57 of 303 id: cord-007733-zh8e76w7 author: DiMenna, Lauren J. title: Pandemic Influenza Vaccines date: 2009-06-15 words: 12736 flesch: 35 summary: This is being addressed by attempts to increase the immunogenicity of influenza virus vaccines through novel adjuvants. FM/1/47 strain of influenza A virus in mice by a monoclonal antibody with cross-neutralizing activity among H1 and H2 strains A PCR based method for the identification of equine influenza virus from clinical samples Development and evaluation of an Influenza virus subtype H7N2 vaccine candidate for pandemic preparedness Trivalent live attenuated intranasal influenza vaccine administered during the 2003-2004 influenza type A (H3N2) outbreak provided immediate, direct, and indirect protection in children Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway The role of alpha/beta and gamma interferons in development of immunity to influenza A virus in mice Development of a recombinant fowlpox virus vector-based vaccine of H5N1 subtype avian influenza Passive transfer of local immunity to influenza virus infection by IgA antibody Vaccines for preventing influenza in the elderly A case-control study of elderly patients with acute respiratory illness: effect of influenza vaccination on admission Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus Partial protection against H5N1 influenza in mice with a single dose of a chimpanzee adenovirus vector expressing nucleoprotein The genesis of a pandemic influenza virus A fused gene of nucleoprotein (NP) and herpes simplex virus genes (VP22) induces highly protective immunity against different subtypes of influenza virus Heterotypic protection against influenza by immunostimulating complexes is associated with the induction of cross-reactive cytotoxic T lymphocytes Immunoprophylactic strategies against respiratory influenza virus infection Lack of antibody production following immunization in old age: association with CD8(+)CD28(−) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines Influenza virus (A/HK/156/97) hemagglutinin expressed by an alphavirus replicon system protects chickens against lethal infection with Hong Kong-origin H5N1 viruses Transient resistance of influenza virus to interferon action attributed to random multiple packaging and activity of NS genes Avian influenza in North and South America Ecology and epidemiology of avian influenza in North and South America Lethal H5N1 influenza viruses escape host anti-viral cytokine responses The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses Generation of an attenuated H5N1 avian influenza virus vaccine with all eight genes from avian viruses Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein A virus obtained from influenza patients Vaccines for preventing influenza in healthy children NK and NK/T cells in human senescence A combination in-ovo vaccine for avian influenza virus and Newcastle disease virus Role of hemagglutinin cleavage for the pathogenicity of influenza virus Crossreactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategy Influenza in old age Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics Live, attenuated influenza keywords: antibodies; avian; cd8; cells; challenge; et al; h5n1; human; immunity; infection; influenza; influenza virus; m2e; mice; pandemic; pathogenic; protection; responses; vaccination; vaccine; virus; viruses cache: cord-007733-zh8e76w7.txt plain text: cord-007733-zh8e76w7.txt item: #58 of 303 id: cord-007784-fq2urilg author: Elderfield, Ruth title: Influenza Pandemics date: 2011-09-22 words: 10510 flesch: 46 summary: However, because of their segmented genomes, influenza viruses are particularly prone to a special form of recombination known as reassortment that occurs if one host is coinfected by two different viruses. The nature of carbohydrate to which influenza virus might attach has been recently studied using glycan arrays. keywords: avian; cell; h1n1; h1n1 influenza; h1n1 virus; host; human; infection; influenza; influenza virus; mutation; pandemic; pb1; protein; receptor; swine; virus; viruses cache: cord-007784-fq2urilg.txt plain text: cord-007784-fq2urilg.txt item: #59 of 303 id: cord-007876-s5y6gyut author: None title: SELECTED EPIDEMICS & EMERGING PATHOGENS – RESPIRATORY ILLNESSES – AN OVERVIEW date: 2017-09-12 words: 2048 flesch: 41 summary: [22] there are new human influenza infections reported. Outbreak of Middle East Respiratory Syndrome coronavirus (MERS CoV) in Saudi Arabia: a retrospective study Severe respiratory illness caused by a novel coronavirus in a patient transferred to the United Kingdom from the Middle East Respiratory Syncytial Virus infection in elderly and high risk adults National Foundation for Infectious Diseases Respiratory Syncytial Virus (RSV) Infection RSV pneumonia, a community-acquired infection in adults Avian Influenza: The Next Pandemic Influenza: lessons from past pandemics, warnings from current incidents Characterization of the reconstructed 1918 Spanish Influenza pandemic virus Changing concepts of airborne infection of acute contagion diseases; a reconsideration of classic epidemiologic theories Probable person to person transmission of avian influenza A H5N1 Avian influenza information for physicians Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells Characterization of the reconstructed 1918 Spanish Influenza pandemic virus Avian influenza virus H5N1: a review of its history and information regarding its potential to cause the next pandemic Differential use of antivirals for treatment of patients with influenza A (H1N1) pdm09 in Germany. keywords: h7n9; human; infection; influenza; virus; viruses cache: cord-007876-s5y6gyut.txt plain text: cord-007876-s5y6gyut.txt item: #60 of 303 id: cord-008584-4eylgtbc author: Singh, David E. title: Evaluating the impact of the weather conditions on the influenza propagation date: 2020-04-05 words: 7281 flesch: 42 summary: Our meteorological model is based on the regression model developed by AB and JS, and it is tuned with influenza surveillance data obtained from SISSS. This component is tuned with influenza surveillance data obtained from SISSS to provide realistic simulations. keywords: climate; conditions; data; humidity; individuals; infection; influenza; model; propagation; simulator; temperature; values; work cache: cord-008584-4eylgtbc.txt plain text: cord-008584-4eylgtbc.txt item: #61 of 303 id: cord-008695-y7il3hyb author: None title: Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic date: 2007-01-25 words: 25930 flesch: 41 summary: London: Health Protection Agency The epidemiology and clinical impact of pandemic influenza The contribution of influenza to combined acute respiratory infections, hospital admissions, and deaths in winter Pandemic versus epidemic influenza mortality: a pattern of changing age distribution Delaying the international spread of pandemic influenza Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings Does this patient have influenza? Clinical signs and symptoms predicting influenza infection Predicting influenza infections during epidemics with use of a clinical case definition The predictive value of influenza symptomatology in elderly people Randomized, placebocontrolled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysis Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. Furthermore, the presence of an influenza-like illness (ILI) comprising of a combination of fever, cough, sore throat, myalgia and headache is not specific for influenza infection. keywords: acute; adults; antibiotic; bacterial; care; children; clinical; community; complications; days; disease; fever; hospital; illness; infection; influenza; influenza pandemic; management; oseltamivir; pandemic; patients; pneumonia; respiratory; therapy; treatment; virus cache: cord-008695-y7il3hyb.txt plain text: cord-008695-y7il3hyb.txt item: #62 of 303 id: cord-008716-38sqkh9m author: Schmidt, Alexander C title: Current research on respiratory viral infections: Third International Symposium date: 2001-06-01 words: 24777 flesch: 38 summary: I. Isolation, properties and characterization Newly recognized myxoviruses from children with respiratory disease Growth on artificial medium of an agent associated with atypical pneumonia and its identification as PPLO Isolation and characterization of adenovirus 5 from the brain of an infant with fatal cerebral edema Respiratory viruses interfere with bacteriologic response to antibiotic in children with acute otitis media Parainfluenza Viruses Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5% proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development Recovery of viruses other than cytomegalovirus from bronchoalveolar lavage fluid Immunity to influenza in man Immunization of types four and seven adenoviruses by selective infection of the intestinal tract Respiratory viral infections in immunocompetent and immunocompromised persons Host responses to respiratory virus infection and immunization Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis Recombinant human respiratory syncytial virus (RSV) monoclonal antibody Fab is effective therapeutically when introduced directly into the lungs of RSV-infected mice The molecular basis of pneumococcal infection: a hypothesis Rehospitalization for respiratory illness in infants of less than 32 weeks' gestation Acute respiratory viral infections in ambulatory children of urban northeast Brazil Heparan sulfate glycosaminoglycans are involved in adenovirus type 5 and 2-host cell interactions Comparison of rapid diagnostic techniques for respiratory syncytial and influenza A virus respiratory infections in young children Human parainfluenza virus type 3 (PIV3) expressing the hemagglutinin protein of measles virus provides a potential method for immunization against measles virus and PIV3 in early infancy Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults Mechanism of protective immunity against influenza virus infection in mice without antibodies Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media. Respiratory virus infections in immunocompromised patients are characterized by persistence of viral infection, prolonged shedding of virus, a high rate of nosocomial acquisition, and a high frequency of pneumonia and death. keywords: adenovirus; adults; age; antibody; cell; children; clinical; day; development; disease; et al; group; human; infants; infected; infection; influenza; influenza virus; mice; pandemic; patients; protein; respiratory; risk; rsv; rsv disease; rsv vaccine; study; syncytial; time; tract; treatment; vaccine; viral; virus; virus infection; viruses; years cache: cord-008716-38sqkh9m.txt plain text: cord-008716-38sqkh9m.txt item: #63 of 303 id: cord-008837-74rfnt1x author: Tsang, Kenneth WT title: H5N1 influenza pandemic: contingency plans date: 2005-08-11 words: 1045 flesch: 39 summary: A viruses in children treated with oseltamivir: descriptive study Avian influenza A (H5N1) in 10 patients in Vietnam New application method of zanamivir with a straw Efficacy and safety of inhaled zanamivir for the treatment of influenza in patients with asthma or chronic obstructive pulmonary disease: a double-blind, randomized, placebocontrolled multicentre study Pharmacoscintigraphic evaluation of lung deposition of inhaled zanamivir in healthy volunteers A comparison of the performance of two modern multidose dry powder asthma inhalers Are we ready for pandemic influenza? Randomised trial of efficacy and safety of inhaled zanamivir in treatment of influenza A and B virus infections Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. keywords: influenza; inhibitors; neuraminidase; zanamivir cache: cord-008837-74rfnt1x.txt plain text: cord-008837-74rfnt1x.txt item: #64 of 303 id: cord-009137-wj5vhvxx author: Fananapazir, L. title: RAISED URINARY FIBRIN-DEGRADATION PRODUCTS, COMPLEMENT, AND IgG DURING AN INFLUENZA-LIKE ILLNESS date: 1977-04-30 words: 2137 flesch: 42 summary: One would expect to find differences in factors which control bilirubin concentration in a group of people with a high bilirubin if they are compared with those with a lower bilirubin. Failure to recognise that the distribution of bilirubin concentration is skewed and the subsequent misapplication of gaussian statistical techniques can yield a misleadingly low upper limit of normal. keywords: bilirubin; controls; illness; infection; influenza; urine cache: cord-009137-wj5vhvxx.txt plain text: cord-009137-wj5vhvxx.txt item: #65 of 303 id: cord-010416-u0yo0lk6 author: Tejada, Sofia title: Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials date: 2020-04-28 words: 4011 flesch: 32 summary: Cochrane Database Syst Rev Cochrane Handbook for Systematic Reviews of Interventions Version 5 Estimating the mean and variance from the median, range, and the size of a sample A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza A and B infections Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial A clinical trial of intravenous peramivir compared with oral oseltamivir for the treatment of seasonal influenza in hospitalized adults Virological response to peramivir treatment in adults hospitalised for influenza-associated lower respiratory tract infections Intravenous peramivir for treatment of influenza A and B virus infection in high-risk patients Intravenous peramivir for treatment of influenza in hospitalized patients Comparison of efficacy of intravenous peramivir and oral oseltamivir for the treatment of influenza: systematic review and meta-analysis Safety and effectiveness of neuraminidase inhibitors for influenza treatment, prophylaxis, and outbreak control: a systematic review of systematic reviews and/or meta-analyses Safety and effectiveness of neuraminidase inhibitors in situations of pandemic and/or novel/variant influenza: a systematic review of the literature, 2009-15 Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009-2010 influenza A(H1N1) pandemic: a systematic review and metaanalysis in hospitalized patients Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a metaanalysis of individual participant data The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza Clinical outcomes of patients treated with intravenous zanamivir for severe influenza A(H1N1)pdm09 infection: a case report series Severe myocarditis due to influenza A(H1N1)pdm09 viral infection in a young woman successfully treated with intravenous zanamivir: a case report CS-8958: long-acting neuraminidase inhibitors for the treatment of influenza Influenza virus polymerase inhibitors in clinical development Phase 3 trial of baloxavir marboxil in high-risk influenza patients (CAP-STONE-2 study) While there is a consensus on dosing and duration of treatment for outpatients and high-risk population, management of influenza treatment in hospitalized and severely ill patients is suboptimal. keywords: influenza; oseltamivir; patients; regimens; studies; therapy; treatment; trials cache: cord-010416-u0yo0lk6.txt plain text: cord-010416-u0yo0lk6.txt item: #66 of 303 id: cord-010786-w3kjc6so author: Ghaderi, Sara title: Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway date: 2019-12-23 words: 3527 flesch: 35 summary: We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. The IRR for emergency hospitalization among MS patients the first week after an influenza diagnosis was 3.4 (95% CI 2.4–4.8). keywords: hospitalization; influenza; pandemic; patients; risk; study cache: cord-010786-w3kjc6so.txt plain text: cord-010786-w3kjc6so.txt item: #67 of 303 id: cord-010959-sigw7yxk author: Lampejo, Temi title: Influenza and antiviral resistance: an overview date: 2020-02-13 words: 4498 flesch: 33 summary: 21 Continued emergence and changing epidemiology of oseltamivir-resistant influenza A(H1N1)2009 virus, United Kingdom, winter 2010/11 A(H1N1) influenza viruses in Japan during the 2008-2009 season Clinical implications of antiviral resistance in influenza Oseltamivir resistance-disabling our influenza defenses Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients Systematic review of influenza resistance to the neuraminidase inhibitors Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses The potential impact of neuraminidase inhibitor resistant influenza Mutations of neuraminidase implicated in neuraminidase inhibitors resistance Recovery of drug-resistant influenza virus from immunocompromised patients: a case series Surveillance and Laboratory Testing of influenza Neuraminidase Inhibitor Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza a infections in the influenza resistance information study. This article discusses these issues including novel agents and experimental strategies that have been used in an attempt to treat as well as prevent the emergence of resistant influenza viruses in humans. keywords: h1n1; influenza; neuraminidase; oseltamivir; patients; resistance; treatment; virus cache: cord-010959-sigw7yxk.txt plain text: cord-010959-sigw7yxk.txt item: #68 of 303 id: cord-011251-rjyipcfv author: Chernyshov, Vladimir V. title: Single-stage synthesis of heterocyclic alkaloid-like compounds from (+)-camphoric acid and their antiviral activity date: 2019-02-28 words: 2798 flesch: 40 summary: In vitro screening for activity influenza virus A was carried out for the obtained compounds. The synthesized quinazoline-like agent 14 has inhibitory activity against different strains of influenza viruses. keywords: acid; activity; camphoric; compounds; influenza; synthesis; virus; yield cache: cord-011251-rjyipcfv.txt plain text: cord-011251-rjyipcfv.txt item: #69 of 303 id: cord-011438-imbpgsub author: Zhang, Yun title: Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection date: 2020-03-29 words: 9339 flesch: 34 summary: hemagglutinin genes Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes A virus nucleoprotein induces apoptosis in human airway epithelial cells: Implications of a novel interaction between nucleoprotein and host protein Clusterin Autophagy induction regulates influenza virus replication in a time-dependent manner Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins Host Immune Response to Influenza A Virus Infection NKp46 O-Glycan Sequences That Are Involved in the Interaction with Hemagglutinin Type 1 of Influenza Virus Evasion of natural killer cells by influenza virus Respiratory Influenza Virus Infection Induces Memory-like Liver NK Cells in Mice Critical Role of Natural Killer Cells in Lung Immunopathology During Influenza Infection in Mice NK cells exacerbate the pathology of influenza virus infection in mice Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection A Role for Neutrophils in Viral Respiratory Disease. keywords: activation; apoptosis; avian; cells; host; human; iav; iavs; ifn; immunity; infection; influenza; pathway; protein; receptor; replication; responses; rna; type; virus; viruses cache: cord-011438-imbpgsub.txt plain text: cord-011438-imbpgsub.txt item: #70 of 303 id: cord-011712-fyrbe8tw author: Venkatesan, Sudhir title: Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection date: 2020-02-01 words: 4625 flesch: 33 summary: Additionally, where data were available, we defined 3 further exposure variables: NAI treatment (at any time) versus no NAI treatment, early NAI treatment (initiated within ≤2 days after symptom onset) versus no NAI treatment, and early NAI treatment versus later treatment (initiated >2 days after symptom onset). In addition, we performed secondary analyses for the following exposures: NAI treatment (at any time) versus no NAI treatment, early NAI treatment (≤48 hours after symptom onset) versus later NAI treatment (>48 hours after symptom onset), and early NAI treatment versus no NAI treatment, adjusting for propensity score, in-hospital antibiotic treatment, and corticosteroid treatment. keywords: data; days; hospital; influenza; los; nai; nai treatment; onset; patients; treatment cache: cord-011712-fyrbe8tw.txt plain text: cord-011712-fyrbe8tw.txt item: #71 of 303 id: cord-011722-82qzf8ht author: Keitel, Wendy A. title: Influenza A(H5N1) Vaccines: Are We Better Prepared for the Next Pandemic? date: 2014-01-01 words: 1999 flesch: 34 summary: Update on avian influenza A (H5N1) virus infection in humans Prioritization of influenza pandemic vaccination to minimize years of life lost Emerging infections: pandemic influenza Pandemic H5N1 influenza vaccine development: an update Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults Safety and immunogenicity of live attenuated influenza reassortant H5 vaccine ( phase I-II clinical trials) Serum hemagglutination inhibiting (HAI) antibodies have been regarded as a benchmark for assessing the immunogenicity of seasonal influenza vaccines by the Food and Drug Administration [10] . keywords: a(h5n1; antibody; influenza; pandemic; vaccines; virus cache: cord-011722-82qzf8ht.txt plain text: cord-011722-82qzf8ht.txt item: #72 of 303 id: cord-011754-lumzp1ca author: Jackson, Michael L. title: Further Evidence for Bias in Observational Studies of Influenza Vaccine Effectiveness: The 2009 Influenza A(H1N1) Pandemic date: 2013-10-15 words: 2813 flesch: 26 summary: After initial instability during weeks when few doses of seasonal influenza vaccine had been given, the hazard ratio trended steadily toward the null over time. Evidence of bias in estimates of influenza vaccine effectiveness in seniors To rule out confounding, observational studies of influenza vaccine need to include analyses during the preinfluenza period Challenges in evaluating influenza vaccine effectiveness and the mortality benefits controversy Effectiveness of influenza vaccine in the community-dwelling elderly Mortality benefits of influenza vaccination in elderly people: an ongoing controversy Clinical effectiveness of influenza vaccination in Manitoba Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly Influenza vaccination: reduction in hospitalizations and death rates among members of Maccabi Healthcare Services during the 2000-2001 influenza season Impact of influenza vaccination on seasonal mortality in the US elderly population Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors Influenza vaccination and all-cause mortality in community-dwelling elderly in Ontario, Canada, a cohort study Influenza vaccination and mortality: differentiating vaccine effects from bias Influenza vaccination and mortality: prospective cohort study of the elderly in a large geographical area Influenza vaccine effectiveness in the elderly based on administrative databases: change in immunization habit as a marker for bias Benefits of influenza vaccine in US elderly-appreciating issues of confounding bias and precision and composition of the 2010-11 influenza vaccine The Vaccine Safety Datalink: a model for monitoring immunization safety Influenza vaccine effectiveness in preventing hospitalizations and deaths in persons 65 years or older in Minnesota Influenza vaccination and risk of community-acquired pneumonia in immunocompetent elderly people: a population-based, nested casecontrol study US Department of Health and Human Services Why do covariates defined by International Classification of Diseases codes fail to remove confounding in pharmacoepidemiologic studies among seniors? Confounding by indication in non-experimental evaluation of vaccine effectiveness: the example of prevention of influenza complications Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus Evidence of bias in studies of influenza vaccine effectiveness in elderly patients Evidence of Bias in Influenza Vaccine Studies 1335 keywords: confounding; influenza; mortality; time; vaccine cache: cord-011754-lumzp1ca.txt plain text: cord-011754-lumzp1ca.txt item: #73 of 303 id: cord-011757-11r3dnse author: van Wijhe, Maarten title: Loose Ends in the Epidemiology of the 1918 Pandemic: Explaining the Extreme Mortality Risk in Young Adults date: 2018-09-06 words: 4382 flesch: 46 summary: Influenza Other Respir Viruses Characterization of the 1918 influenza virus polymerase genes Dating the emergence of pandemic influenza viruses Further Elucidating 1918 H1N1 Mortality Patterns 2509 Pandemic versus epidemic influenza mortality: a pattern of changing age distribution Epidemiological evidence of an early wave of the 1918 influenza pandemic in New York City Death patterns during the 1918 influenza pandemic in Chile Epidemiologic characterization of the 1918 influenza pandemic summer wave in Copenhagen: implications for pandemic control strategies A review of the 1918 herald pandemic wave: importance for contemporary pandemic response strategies Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysis Mortality patterns associated with the 1918 influenza pandemic in Mexico: evidence for a spring herald wave and lack of preexisting immunity in older populations The 1918-19 influenza pandemic in Boyacá, Colombia. According to a third theory, the pandemic originated in inner northern China, where in 1917-1918, an epidemic of pneumonic plague (12) may have been pandemic influenza that then spread to Europe via Chinese migrant workers (13) . keywords: age; death; group; influenza; pandemic; risk; virus; years cache: cord-011757-11r3dnse.txt plain text: cord-011757-11r3dnse.txt item: #74 of 303 id: cord-011917-6u0t4hy8 author: Skarlupka, Amanda L. title: Immune Imprinting in the Influenza Ferret Model date: 2020-04-08 words: 7911 flesch: 31 summary: Nearly 500,000 annual global deaths are attributed to influenza virus infection [1] . The ferret model is used to study influenza virus infection because of the ferret's natural susceptibility, shared clinical signs of illness, and possession of similarities in respiratory physiology, cell composition, and distribution of sialic acid receptors. keywords: a(h1n1; ferrets; immune; immunity; infection; influenza; model; pandemic; pre; response; vaccination; vaccine; virus; viruses cache: cord-011917-6u0t4hy8.txt plain text: cord-011917-6u0t4hy8.txt item: #75 of 303 id: cord-013022-c8a8ocge author: Vázquez-Espinosa, Emma title: The Spanish flu and the fiction literature date: 2020-07-07 words: 4421 flesch: 62 summary: Other nicknames were Spanish flu or Spanish Lady, also French flu. Spanish flu caused the faculties to close and Plá returns to his town, Palafrugell, to the family home: Since there is so much flu they have had to close the College… The flu continues to relentlessly kill people. keywords: authors; disease; fever; flu; gripe; influenza; literature; madrid; pandemic; spain; spanish; war cache: cord-013022-c8a8ocge.txt plain text: cord-013022-c8a8ocge.txt item: #76 of 303 id: cord-013073-siy7dvlo author: Pfäfflin, Albrecht title: Influenza virus-flow from insects to humans as causative for influenza seasonality date: 2020-10-09 words: 1846 flesch: 38 summary: The clock-like consistency of the winter incidence peaks of influenza virus in temperate climatic regions represents a strong example of seasonality in infectious disease [2] . The reservoir of influenza virus are aquatic birds keywords: humans; influenza; insects; transmission; virus cache: cord-013073-siy7dvlo.txt plain text: cord-013073-siy7dvlo.txt item: #77 of 303 id: cord-015646-tt2p9uue author: Xue, Lan title: Global Strategies and Response Measures to the Influenza A (H1N1) Pandemic date: 2018-11-24 words: 9340 flesch: 34 summary: 9 In addition to its preparation and alert efforts, the WHO also strengthened pandemic monitoring and introduced a series of strategies and measures relating to pandemic response, treatment, vaccine development, inoculation, and distribution. (UPMC's) Center for Biosecurity held a conference to summarize important lessons learned from pandemic responses and raised policy suggestions in mitigating future infectious disease emergencies. keywords: control; countries; government; h1n1; health; influenza; influenza pandemic; measures; national; pandemic; prevention; public; response; states; united; virus cache: cord-015646-tt2p9uue.txt plain text: cord-015646-tt2p9uue.txt item: #78 of 303 id: cord-015764-ly68q5z0 author: Poissy, J. title: La modulation de la signature transcriptomique de l’hôte infecté : une nouvelle stratégie thérapeutique dans les viroses graves ? Exemple de la grippe date: 2016-04-07 words: 3988 flesch: 39 summary: Les progrès en termes de diagnostic ont permis de montrer qu'une large part de ces infections est due à des virus. [41] [42] , et en particulier le développement de la biologie des systèmes, ont considérablement enrichi les connaissances concernant les interactions complexes et multiples entre ces virus et la « machinerie » cellulaire. keywords: cellulaire; ces; cette; dans; des; est; influenza; l'infection; les; molécules; nous; par; pour; que; sont; sur; une; virus; viruses cache: cord-015764-ly68q5z0.txt plain text: cord-015764-ly68q5z0.txt item: #79 of 303 id: cord-015830-ha8oj1b3 author: Van Essen, A G title: NHG-Standaard Influenzapandemie date: 2009-02-16 words: 10619 flesch: 49 summary: Tijdens een manifeste influenzapandemie (WHO-fase 6) is het vertragen van de pandemie van groot belang. Na besmetting vermenigvuldigt het virus zich in het epitheel van de (lage) luchtwegen. keywords: aan; aantal; als; andere; antivirale; aviaire; behandeling; beleid; bij; contact; contacten; dagen; dan; dat; deze; die; dit; door; echter; een; eerste; fase; geadviseerd; geen; h5n1; hebben; heeft; het; huisarts; infectie; influenza; influenzapandemie; influenzavirus; jaar; kan; klinische; kunnen; middelen; mogelijk; nhg; niet; nog; omdat; onder; ook; oseltamivir; pandemisch; patiënt; patiënten; postexpositieprofylaxe; profylaxe; standaard; symptomen; tegen; tijdens; tot; uit; van; virus; voor; worden; wordt; zal; zich; zijn; zou cache: cord-015830-ha8oj1b3.txt plain text: cord-015830-ha8oj1b3.txt item: #80 of 303 id: cord-016475-7ldxvbpz author: Pleschka, Stephan title: Anti-viral approaches against influenza viruses date: 2006 words: 17141 flesch: 32 summary: Apoptosis is mainly regarded to be a host cell defense against virus viruses (reviewed in: Julkunen et al., 2000; Ludwig et al., 2003; infections since many viruses express anti-apoptotic proteins to prevent this cellular response. The etiological agent of the disease, influenza virus is responsible E. Bogner and A. Holzenburg (eds.) , New Concepts of Antiviral Therapy, 115-167. keywords: activation; activity; anti; apoptosis; cell; disease; et al; human; immunity; induction; infection; influenza; influenza virus; inhibitors; kinase; mek; neuraminidase; oseltamivir; pathway; production; protein; replication; response; strain; treatment; type; vaccine; viral; virus; viruses; zanamivir cache: cord-016475-7ldxvbpz.txt plain text: cord-016475-7ldxvbpz.txt item: #81 of 303 id: cord-016995-5izyl234 author: Auewarakul, Prasert title: The Past and Present Threat of Avian Influenza in Thailand date: 2008 words: 5105 flesch: 49 summary: GlcNAc-containing receptors Free-grazing ducks and highly pathogenic avian influenza Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004 Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR H5N1 influenza: A protean pandemic threat Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia Three Indonesian clusters of H5N1 virus infection in 2005 Avian influenza H5N1 in tigers and leopards Characterization of the hemagglutinin and neuraminidase genes of recent influenza virus isolates from different avian species in Thailand Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis) Avian H5N1 influenza in cats Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics Containing pandemic influenza at the source Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties World Organization for Animal Health. The evolution of H5N1 influenza viruses in ducks in southern China Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004 A child with avian influenza A (H5N1) infection Human disease from influenza A (H5N1) Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma Department of Livestock Development. keywords: avian; et al; h5n1; influenza; poultry; thailand; virus; viruses cache: cord-016995-5izyl234.txt plain text: cord-016995-5izyl234.txt item: #82 of 303 id: cord-017291-bhe34dky author: Cohen, Cheryl title: Influenza date: 2017-05-05 words: 7132 flesch: 36 summary: Adjuvanted formulations of influenza vaccine are licensed for use in individuals aged ≥65 years in the USA but not currently in children [39] . Children aged 6 months through 8 years should receive two influenza doses administered ≥4 weeks apart the first time influenza vaccine is administered. keywords: children; disease; illness; individuals; infection; influenza; risk; treatment; vaccination; vaccine; virus; viruses; years cache: cord-017291-bhe34dky.txt plain text: cord-017291-bhe34dky.txt item: #83 of 303 id: cord-017354-cndb031c author: Janies, D. title: Large-Scale Phylogenetic Analysis of Emerging Infectious Diseases date: 2008 words: 12430 flesch: 42 summary: Here we review the computational challenges of comparative genomic analyses, specifically sequence alignment and reconstruction of phylogenetic trees. Phylogenetic trees are represented by acyclic graphs in which the leaves of these graphs represent the observed biological entities (taxa) being compared (e.g., sequences of genes, genomes, and/or anatomy of individuals, isolates or cultivars, species, or any higher level taxonomic unit). keywords: alignment; analysis; avian; character; data; host; human; influenza; isolates; length; methods; number; organisms; outgroup; search; sequence; strains; taxa; tree; viruses cache: cord-017354-cndb031c.txt plain text: cord-017354-cndb031c.txt item: #84 of 303 id: cord-017733-xofwk88a author: Davis, Mark title: Uncertainty and Immunity in Public Communications on Pandemics date: 2018-11-04 words: 4522 flesch: 41 summary: Individualized ideas of immunity in connection with uncertainties may limit the effectiveness of public health communications on influenza pandemics and other contagious threats. The individualization of responses to pandemic risk communications was supported by our own research. keywords: advice; communications; health; immunity; influenza; pandemic; public; risk cache: cord-017733-xofwk88a.txt plain text: cord-017733-xofwk88a.txt item: #85 of 303 id: cord-017748-xy26tk0t author: Georgiev, Vassil St. title: Influenza date: 2009 words: 11778 flesch: 31 summary: The effect of influenza on hospitalizations, outpatient visits and courses of antibiotics in children Influenza and the rates of hospitalization for respiratory disease among infants and young children Report of the Blue Ribbon Panel on Influenza Research Safety of high doses of influenza vaccine and effect on antibody responses in elderly persons Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparation Emerging respiratory viruses: challenges and vaccine strategies Avian flu to human influenza Confronting the avian influenza threat: vaccine development for a potential pandemic Avian influenza A (H5N1) infection in humans Avian influenza A (H5N1) Immunity to influenza in man Determinants of immunity to influenza infection in man The role of the antibody response in influenza virus infection Antiviral activity of antiserum specific for an influenza virus neuraminidase Association of serum anti-neuraminidase antibody with resistance to influenza in man Continuing evolution of H9N2 influenza viruses in Southeastern China Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome Novel avian influenza H7N3 strain outbreak Recombination resulting in virulence shift in avian influenza outbreak H1 and H7 influenza haemagglutinin structures extend a structural classification of haemagglutinin subtypes Evolution and ecology of influenza A viruses Phylogenetic analysis of H7 haemagglutinin subtype influenza A viruses Transmission of Eurasian avian H2 influenza virus to shorebirds in North America The molecular epidemiology of influenza virus Structural basis of immune recognition of influenza virus hemagglutinin Development of cell culture (MDCK) live cold-adapted (CA) attenuated influenza vaccine A new European perspective of influenza pandemic planning with a particular focus on the role of mammalian cell culture vaccines Protective efficacy of intranasal cold-adapted influenza A/New Caledonia/20/99 (H1N1) vaccines comprised of egg-or cell culture-derived reassortants A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans Vaccines against H5N1 influenza Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate Immunity to influenza A H9N2 viruses induced by infection and vaccination Avirulent avian influenza virus as a vaccine strain against a potential human pandemic Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics Immunization with reverse-geneticsproduced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge Cross-protectiveness and immunogenicity of influenza A/Duck/Singapore/3/97 (H5) vaccines against infection with A/Vietnam/1203/04 (H5N1) virus in ferrets Generation of influenza vaccine viruses on Vero cells by reverse genetics: an H5N1 candidate vaccine strain produced under a quality system Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza Boosting immunity to influenza H5N1 with MF59-adjuvanted H5N3 Singapore/97 vaccine in a primed human population Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase I randomised trial Pandemic preparedness: lessons learnt from H2N2 and H9N2 candidate vaccines Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a phase I randomised controlled trial Trials of influenza A/New Jersey/76 virus vaccine in normal children: an overview of age-related antigenicity and reactogenicity Safety and antigenicity of whole virus and subunit influenza A/Hong Kong/1073/99 (H9N2) vaccine in healthy adults: phase I randomised trial Summary of clinical trials of influenza virus vaccines in adults Generation of high-yielding influenza Not until 1933, when the first human influenza virus was isolated, was it possible to define with certainty which pandemics were caused by influenza viruses. keywords: avian; h5n1; h9n2; hemagglutinin; human; immunity; infection; influenza; influenza virus; mice; niaid; pandemic; protein; studies; subtypes; vaccine; virus; viruses cache: cord-017748-xy26tk0t.txt plain text: cord-017748-xy26tk0t.txt item: #86 of 303 id: cord-017893-ck0m3h7u author: Sandrock, C. title: Update on Avian Influenza for Critical Care Physicians date: 2007 words: 4044 flesch: 41 summary: More recently, avian influenza viruses have been found to directly infect humans from their avian hosts. More recently, avian influenza viruses have been found to directly infect humans from their avian hosts. keywords: avian; cases; h5n1; hpai; human; influenza; neuraminidase; subtypes; virus; viruses cache: cord-017893-ck0m3h7u.txt plain text: cord-017893-ck0m3h7u.txt item: #87 of 303 id: cord-018089-m94q75xn author: Mubareka, Samira title: Influenza Virus: The Biology of a Changing Virus date: 2010-06-18 words: 7049 flesch: 35 summary: Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04 Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals Residue 627 of PB2 is a determinant of cold sensitivity in RNA replication of avian influenza viruses Transmission of influenza virus in a mammalian host is increased by PB2 amino acids 627K or 627E/701N Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1 Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice Type 1 interferons and the virus-host relationship: a lesson in detente The multifunctional NS1 protein of influenza A viruses The NS1 gene contributes to the virulence of H5N1 avian influenza viruses Large-scale sequence analysis of avian influenza isolates Glycosylation of neuraminidase determines the neurovirulence of influenza A/WSN/33 virus Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells Reverse genetics provides direct evidence for a correlation of hemagglutinin cleavability and virulence of an avian influenza A virus Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses Influenza seasonality: underlying causes and modeling theories Seasonal dynamics of recurrent epidemics Review of aerosol transmission of influenza Finally, recent advances in our understanding of the seasonality and transmission of influenza viruses are described, and their importance for the control of the spread of these viruses is discussed. keywords: acid; avian; binding; h1n1; h5n1; host; human; infection; influenza; pandemic; pb1; receptor; rna; transmission; virus; viruses cache: cord-018089-m94q75xn.txt plain text: cord-018089-m94q75xn.txt item: #88 of 303 id: cord-018213-w6sh9f3h author: Xue, Lan title: China’s Institutional Mechanisms for Influenza A (H1N1) Prevention and Control date: 2018-11-24 words: 8200 flesch: 21 summary: After the 2003 SARS Epidemic, local governments established permanent public health emergency response departments and corresponding working mechanisms to deal with future public health emergencies. This clarification brought about effective collaboration between the government and the society in public health emergency management. keywords: control; control mechanism; departments; emergency; epidemic; h1n1; health; influenza; joint; management; mechanism; prevention; public; response; work cache: cord-018213-w6sh9f3h.txt plain text: cord-018213-w6sh9f3h.txt item: #89 of 303 id: cord-018811-zhwr3h07 author: Oxford, John title: Influenza Vaccines Have a Short but Illustrious History of Dedicated Science Enabling the Rapid Global Production of A/Swine (H1N1) Vaccine in the Current Pandemic date: 2010-06-18 words: 13262 flesch: 44 summary: Immunogenicity and original antigenic sin in humans The specificity of the antihaemagluttinin antibody response induced in man by inactivated vaccines and by natural infection Strain specificity of serum antibody to the haemagglutinin of influenza A (H3N2) viruses in children following immunisation or natural infection Immunisation with influenza virus a vaccines: comparison of intradermal and subcutaneous routes Immunisation with Asian strain influenza vaccineequivalence of the subcutaneous and intradermal routes Effect of dosage and route of inoculation upon antigenicity of inactivated influenza virus vaccine (Hong Kong strain) in man Influenza antibody in human respiratory secretions after subcutaneous or respiratory immunisation with inactivated virus Specificity of respiratory secretion antibody against influenza virus Purified influenza vaccine; clinical and serological response to varying doses and different routes of immunisation Antibody in respiratory secretions following immunisation with influenza virus vaccines Humoral and secretory antibody responses to immunisation with low and high dosage split influenza virus vaccines Neurological illness is a recognized sequel to immunization with a variety of vaccines but had not previously been observed with any frequency after influenza virus vaccines. keywords: antibody; children; dose; h1n1; h3n2; infection; influenza; influenza vaccine; influenza virus; new; pandemic; response; strain; swine; vaccine; virus; virus vaccine; viruses; volunteers; years cache: cord-018811-zhwr3h07.txt plain text: cord-018811-zhwr3h07.txt item: #90 of 303 id: cord-019010-9xgwjvsv author: Luna, C. M. title: Life-threatening Respiratory Failure from H1N1 Influenza: Lessons from the Southern Cone Outbreak date: 2010-06-23 words: 4579 flesch: 30 summary: It remains unknown whether these cases were secondary to some of the several risk factors that these bed-ridden severely ill patients had, or whether it was a direct consequence of a particular risk in influenza patients. Renal failure has been described in a number of influenza patients [7, 31] . keywords: ards; h1n1; infection; influenza; pandemic; patients; peep; pneumonia; pressure; ventilation; virus cache: cord-019010-9xgwjvsv.txt plain text: cord-019010-9xgwjvsv.txt item: #91 of 303 id: cord-019057-3j2fl358 author: Afolabi, Michael Olusegun title: Pandemic Influenza: A Comparative Ethical Approach date: 2018-08-28 words: 13976 flesch: 46 summary: In a manner of speaking, it seems that PHDs such as pandemic influenza outbreaks have evolved to become recurring features of the human experience. The importance of this last remark will become clearer against the backdrop of the social and global features of pandemic influenza outbreaks, a. theme addressed in the next section of this chapter. keywords: care; ethics; health; help; human; infection; influenza; influenza outbreaks; influenza pandemic; influenza virus; instance; issues; outbreak; pandemic; people; public; rights; vaccines; virus cache: cord-019057-3j2fl358.txt plain text: cord-019057-3j2fl358.txt item: #92 of 303 id: cord-020466-hdcke0d4 author: Hammel, Jean M. title: Commentary date: 2004-11-19 words: 1910 flesch: 46 summary: Aquatic birds serve as the primary reservoir for influenza A, carrying the viruses largely without adverse effects. Eighteen people were infected with influenza A (H5N1) in Hong Kong in 1997; 6 died. keywords: avian; h5n1; health; human; influenza; strains cache: cord-020466-hdcke0d4.txt plain text: cord-020466-hdcke0d4.txt item: #93 of 303 id: cord-020756-d9f5fd7x author: de Jong, Menno Douwe title: Avian Influenza Viruses and Pandemic Influenza date: 2007 words: 15084 flesch: 31 summary: A viruses differ from human viruses by recognition of sialyloligosaccharides and gangliosides and by a higher conservation of the HA receptor-binding site The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity Human and avian influenza viruses target different cell types in cultures of human airway epithelium Transmissibility of 1918 pandemic influenza Clinical signs and symptoms predicting influenza infection Encephalitis and encephalopathy associated with an influenza epidemic in Japan Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong Mutations in the hemagglutinin receptorbinding site can change the biological properties of an influenza virus Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950 Human influenza virus hemagglutinin with high sensitivity to proteolytic activation Avian influenza and sialic acid receptors: more than meets the eye? Nonhomologous recombination between the hemagglutinin gene and the nucleoprotein gene of an influenza virus Influenza A pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiology Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice Functional anatomy of human lacrimal duct epithelium Human infection with influenza H9N2 Cocirculation of avian H9N2 and contemporary human H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? Re-emergence of fatal human influenza A subtype H5N1 disease Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand Origin and evolution of the 1918 Spanish influenza virus hemagglutinin gene Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus Pathogenesis of influenza A (H5N1) virus infection in a primate model Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity Receptor binding properties of human and animal H1 influenza virus isolates Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays The polymerase complex genes contribute to the high virulence of the human H5NI influenza virus isolate A/Vietnam/1203/04 Host range recombinants of fowl plague (influenza A) virus Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1) This is also suggested by the establishment of multiple geographically distinct sublineages of H5N1 influenza viruses in Asia . keywords: acid; avian; birds; cases; et al; gene; h5n1; h5n1 influenza; h5n1 viruses; hong; host; human; infection; influenza; influenza viruses; kong; outbreak; pandemic; pathogenic; poultry; strains; transmission; viruses cache: cord-020756-d9f5fd7x.txt plain text: cord-020756-d9f5fd7x.txt item: #94 of 303 id: cord-020789-slsfhrkx author: Kleines, Michael title: Virale Atemwegserkrankungen – Influenza, RSV und neue Viren date: 2017-10-27 words: 3373 flesch: 38 summary: In der Frühphase der Impfstoffentwicklung wurden trivalente (2 Influenza-A-Virus-Stämme, 1 Influenza-B-Virus-Stamm) Ganzvirus-Impfstoffe der 1. Enteroviren gehören zur Gattung Enterovirus in der Familie der Picornaviren. keywords: aber; auch; bei; bis; das; den; der; des; die; durch; eine; für; infektionen; influenza; ist; mit; nicht; nur; oder; phase; rsv; sich; sind; und; viren; virus; von; werden; zur cache: cord-020789-slsfhrkx.txt plain text: cord-020789-slsfhrkx.txt item: #95 of 303 id: cord-023666-r9zaf6un author: Rao, Suchitra title: Influenza date: 2018-03-13 words: 5109 flesch: 31 summary: Influenza Other Respir Viruses Acute fever and petechial rash associated with influenza A virus infection The spectrum of histopathologic findings in cutaneous eruptions associated with influenza A (H1N1) infection Coexistence of two adamantane binding sites in the influenza A M2 ion channel Leukocytoclastic vasculitis associated with influenza A virus infection Radiological findings in 210 paediatric patients with viral pneumonia: a retrospective case study Pulmonary infections Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China Hospitalized patients with 2009 H1N1 influenza in the United States An assessment of H1N1 influenza-associated acute respiratory distress syndrome severity after adjustment for treatment characteristics Altered receptor specificity and cell tropism of D222G hemagglutinin mutants isolated from fatal cases of pandemic A (H1N1) 2009 influenza virus Association of D222G substitution in haemagglutinin of 2009 pandemic influenza A (H1N1) with severe disease Influenza A (H1N1) vs non-H1N1 ARDS: analysis of clinical course Bench-to-bedside review: bacterial pneumonia with influenza-pathogenesis and clinical implications Critically ill children during the 2009-2010 influenza pandemic in the United States When to consider the use of antibiotics in the treatment of 2009 H1N1 influenza-associated pneumonia Seasonal influenza in adults and children-diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America Accuracy of rapid influenza diagnostic tests: a meta-analysis Oral oseltamivir treatment of influenza in children Effect of oseltamivir on the risk of pneumonia and use of health care services in children with clinically diagnosed influenza Viral shedding in children with influenza virus infections treated with neuraminidase inhibitors Oseltamivir treatment for influenza in hospitalized children without underlying diseases Oseltamivir shortens hospital stays of critically ill children hospitalized with seasonal influenza: a retrospective cohort study Orthomyxoviridae: the viruses and their replication Influenza vaccine-outmaneuvering antigenic shift and drift The evolution of human influenza viruses Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study Community-acquired pneumonia requiring hospitalization among U.S. children Global role and burden of influenza in pediatric respiratory hospitalizations, 1982-2012: a systematic analysis Virulence determinants of pandemic influenza viruses Viral infection of the lung: host response and sequelae Influenza A virus infection, innate immunity, and childhood Novel insights into immune and inflammatory responses to respiratory viruses Pathogenesis of influenzainduced acute respiratory distress syndrome Case records of the Massachusetts General Hospital. Influenza viruses have developed ways to evade the body's immune response using an antigenic variation known as antigenic shift (replacement of HA and NA antigens with novel subtypes from noninfluenza viruses) and drift (mutations within antibody-binding sites in HA and or NA). keywords: acute; children; illness; infection; influenza; pneumonia; risk; treatment; vaccine; viruses cache: cord-023666-r9zaf6un.txt plain text: cord-023666-r9zaf6un.txt item: #96 of 303 id: cord-023859-3v9cmok0 author: Pinsky, Benjamin A. title: Influenza A (H1N1) date: 2011-03-08 words: 2203 flesch: 41 summary: Novel Swine-Origin Influenza A Virus Investigation Team Historical perspective-emergence of influenza A (H1N1) viruses H1N1 influenza Preferential lower respiratory tract infection in swine-origin 2009 A(H1N1) influenza Answers to Multiple Choice Questions 1 . In order to subtype influenza A, a majority of assays target unique sequences in the influenza A hemagglutinin (HA or H) gene keywords: h1n1; influenza; oseltamivir; patient; resistance; virus cache: cord-023859-3v9cmok0.txt plain text: cord-023859-3v9cmok0.txt item: #97 of 303 id: cord-026641-eemp6b5j author: Kabiljo, Julijan title: From threat to cure: understanding of virus-induced cell death leads to highly immunogenic oncolytic influenza viruses date: 2020-06-11 words: 6705 flesch: 28 summary: A virus replication in vitro through induction of toll-like receptor 3 dependent apoptosis Regulated necrosis: the expanding network of non-apoptotic cell death pathways Radiotherapy as a backbone for novel concepts in cancer immunotherapy Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival Pathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus Highly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3 H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death The NS1 protein of influenza Influenza virus is an enveloped, negative-strand RNA virus with no reverse transcriptase or DNA integration activity 28 . keywords: activation; apoptosis; cancer; cell; death; immunogenic; infection; influenza; ns1; oncolytic; protein; rna; tumor; virus; viruses cache: cord-026641-eemp6b5j.txt plain text: cord-026641-eemp6b5j.txt item: #98 of 303 id: cord-026982-1igz6i8u author: Li, Yanbo title: The association between the seasonality of pediatric pandemic influenza virus outbreak and ambient meteorological factors in Shanghai date: 2020-06-17 words: 4602 flesch: 33 summary: Specifically, we found both lower (below 5°C) and higher temperature (above 25-30°C) (a U-shaped curve relationship) were strongly associated with a higher incidence of pediatric influenza A, which corresponds to two previous studies [5, 33] . Hum Vaccines Immunother Environmental predictors of seasonal influenza epidemics across temperate and tropical climates Comparison of the incidence of influenza in relation to climate factors during 2000-2007 in five countries Climate change and influenza: the likelihood of early and severe influenza seasons following warmer than average winters Different responses of influenza epidemic to weather factors among Shanghai, Hong Kong, and British Columbia Influenza (Seasonal) Air pollution, temperature and pediatric influenza in The spatio-temporal response of influenza A (H1N1) to meteorological factors in Beijing Epidemiological analysis of influenza in Nanjing children's hospital from 2013 to 2017 Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations keywords: factors; influenza; mean; meteorological; temperature cache: cord-026982-1igz6i8u.txt plain text: cord-026982-1igz6i8u.txt item: #99 of 303 id: cord-027752-xcpv9k22 author: Bresalier, Michael title: Uses of a Pandemic: Forging the Identities of Influenza and Virus Research in Interwar Britain date: 2011-12-15 words: 10133 flesch: 52 summary: He argued that those who viewed influenza virus as a microorganism had no direct method for distinguishing it from protein particles. It shows that the organisation of medical virus research was inextricably linked to the pandemic before the actual discovery of flu virus in 1933. keywords: disease; distemper; epidemic; filter; filterable; influenza; medical; mrc; new; pandemic; pathology; research; virus; virus research; viruses; war; work cache: cord-027752-xcpv9k22.txt plain text: cord-027752-xcpv9k22.txt item: #100 of 303 id: cord-028564-sltofaox author: Gutiérrez-Spillari, Lucia title: Obesity, Cardiovascular Disease, and Influenza: How Are They Connected? date: 2020-07-06 words: 3323 flesch: 26 summary: Cardiovascular complications associated with influenza infection include myocarditis, pericardial effusion, myopericarditis, right and left ventricle dysfunction, myocardial infarction, heart failure, stroke, and circulatory failure due to septic shock [13, [18] Influenza infection can trigger type 1 and type 2 myocardial infarctions [16] . keywords: cardiovascular; disease; heart; infection; influenza; patients; risk; vaccination cache: cord-028564-sltofaox.txt plain text: cord-028564-sltofaox.txt item: #101 of 303 id: cord-030279-pv770doe author: Novossiolova, Tatyana title: Twenty-first Century Governance Challenges in the Life Sciences date: 2016-11-29 words: 15223 flesch: 33 summary: In the aftermath of 9/11 and the 'Anthrax letters' attack of October 2001, substantial effort has been given to harnessing life science research for the purposes of national security. 31 University-industry partnerships, while not a novel phenomenon in the area of biotechnology, have considerably intensified over the past several decades, thus facilitating the widespread commercialisation of life science research. keywords: biology; biotechnology; case; concerns; development; governance; government; health; human; industry; innovation; laboratory; life; life science; new; novel; potential; public; research; risk; science; science research; scientists; security; synthetic; systems; technologies; time; use; virus cache: cord-030279-pv770doe.txt plain text: cord-030279-pv770doe.txt item: #102 of 303 id: cord-030853-3yryw3r2 author: Vashishtha, Vipin M. title: Seasonal Influenza Vaccination and the Heightened Risk of Coronavirus and Other Pandemic Virus Infections: Fact or Fiction? date: 2020-06-09 words: 984 flesch: 24 summary: Med Hypotheses Assessment of temporally-related acute respiratory illness following influenza vaccination Increased risk of non-influenza respiratory virus infections associated with receipt of inactivated influenza vaccine Influenza vaccination and respiratory virus interference among Department of Defence personnel during the 2017-2018 influenza season Respiratory virus induction of alpha-, beta-and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells [5] found an increased incidence of acute respiratory infection in children by non-influenza respiratory viruses among 999 participants (out of which 68.8% were children) following influenza vaccination compared to unvaccinated children during the same period. keywords: influenza; virus; viruses cache: cord-030853-3yryw3r2.txt plain text: cord-030853-3yryw3r2.txt item: #103 of 303 id: cord-048448-kfwbqp4p author: Sandrock, Christian title: Clinical review: Update of avian influenza A infections in humans date: 2007-03-22 words: 4457 flesch: 40 summary: The appearance of H3 influenza viruses in seals Are seals frequently infected with avian influenza viruses? Characterization of an influenza A virus from seals Transmission of equine influenza virus to dogs Avian influenza H5N1 in viverrids: implications for wildlife health and conservation Characterization of an avian influenza A virus isolated from a human -is an intermediate host necessary for the emergence of pandemic influenza viruses Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness Evolution and ecology of influenza A viruses Antigenic and genetic characterization of a novel hemagglutinin subtype of influenza A viruses from gulls Molecular characterization of a new hemagglutinin, subtype H14, of influenza A virus Characterization of a novel influenza hemagglutinin, H15: criteria for determination of influenza A subtypes Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late Highly pathogenic H5N1 influenza virus infection in migratory birds Reemerging H5N1 viruses in Hong Kong in 2002 are highly pathogenic to ducks Genesis of a highly pathogenic and potentially pandemic H5N1 virus in eastern Asia New genotype of avian influenza H5N1 viruses isolated from tree sparrows in China Characterization of H5N1 influenza A viruses isolated during the 2003-2004 influenza outbreaks in Japan. Pathology of fatal human infection associated with avian influenza A H5N1 virus Risk of influenza A (H5N1) infection among poultry workers Development of a realtime reverse transcriptase PCR assay for type A influenza virus and the avian H5 and H7 hemagglutinin subtypes Application of real-time RT-PCR for the quantitation and competitive replication study of H5 and H7 subtype avian influenza virus Single-step multiplex reverse transcription-polymerase chain reaction (RT-PCR) for influenza A virus subtype H5N1 detection The World Health Organization Global Influenza Program Surveillance Network: Evolution of H5N1 avian influenza viruses in Asia Emergence of drug-resistant influenza virus: population dynamical considerations Antiviral agents. keywords: avian; cases; disease; h5n1; health; hpai; human; infection; influenza; virus; viruses cache: cord-048448-kfwbqp4p.txt plain text: cord-048448-kfwbqp4p.txt item: #104 of 303 id: cord-103085-vf4qyvft author: Seitz, Christian title: Multiscale simulations examining glycan shield effects on drug binding to influenza neuraminidase date: 2020-11-02 words: 9741 flesch: 42 summary: In this work, we define binding site contacts to be those protein-ligand contacts seen in crystal structures. Our work shows that glycans can have an inhibitory effect on influenza NA primary site binding. keywords: acid; association; binding; conformation; figure; glycans; glycosylation; influenza; ligand; neuraminidase; oseltamivir; protein; simulations; site; site binding; structure; virus cache: cord-103085-vf4qyvft.txt plain text: cord-103085-vf4qyvft.txt item: #105 of 303 id: cord-103560-28o0bauv author: Yechezkel, M. title: Optimizing antiviral treatment for seasonal influenza in the United States: A Mathematical Modeling Analysis date: 2020-07-30 words: 7964 flesch: 44 summary: Update: Influenza activity in the United States during the 2016-17 season and composition of the 2017-18 influenza vaccine Patterns of influenza vaccination coverage in the United States from 2009 to 2015 Influenza activity -United States, 2015-16 season and composition of the 2016-17 influenza vaccine Interim Estimates of 2018-19 Seasonal Influenza Vaccine Effectiveness -United States Oseltamivir for treatment and prevention of pandemic influenza A/H1N1 virus infection in households Antiviral agents for the treatment and chemoprophylaxis of influenza ---recommendations of the Advisory Committee on Immunization Practices (ACIP) Prevention and control of influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP) Heterogeneous and dynamic prevalence of asymptomatic influenza virus infections Update: Influenza activity in the united states during the 2017-18 season and composition of the 2018-19 influenza vaccine Antiviral effects on influenza viral transmission and pathogenicity: Observations from household-based trials Antiviral Management of Seasonal and Pandemic Influenza Improving Delivery of Early Treatment to Influenza-Infected Patients Natural attack rate of influenza in unvaccinated children and adults: a meta-regression analysis Epidemiology, complications, and cost of hospitalization in children with laboratoryconfirmed influenza infection Antibodies Cross-Reactive to Influenza A (H3N2) Variant Virus and Impact of 2010-11 Seasonal Influenza Vaccine on Cross-Reactive Antibodies -United States Early administration of oral oseltamivir increases the benefits of influenza treatment Nonpharmaceutical interventions for pandemic influenza, international measures Influenza-like illness, the time to seek healthcare, and influenza antiviral receipt during the 2010-2011 influenza season -United States Antibodies cross-reactive to influenza a (H3N2) variant virus and impact of 2010-11 seasonal influenza vaccine on cross-reactive antibodies -United States CDC Seasonal Flu Vaccine Effectiveness Studies | CDC The US Influenza Hospitalization Surveillance Network 21 The minimal infectious dose of adenovirus type 4; the case for natural transmission by viral aerosol Berman All rights reserved. The population-level impact of increased timeliness and coverage of treatment among high-risk patients was observed regardless of seasonal influenza vaccination coverage and the severity of the influenza season. keywords: age; coverage; influenza; medrxiv; preprint; risk; treatment cache: cord-103560-28o0bauv.txt plain text: cord-103560-28o0bauv.txt item: #106 of 303 id: cord-103972-kbv9kh6z author: Singer, Gregor title: Air Pollution Increases Influenza Hospitalizations date: 2020-04-10 words: 5598 flesch: 50 summary: Column (1) implies a 1-unit increase in the lagged monthly AQI results in a 0.56% increase in inpatient influenza admissions. Figure 2a shows a clear positive correlation between air quality and count of influenza admissions in the raw data; higher AQI correlates with more influenza admissions (43). keywords: admissions; air; aqi; arizona; county; data; effects; hospital; influenza; inpatient; month; pollution; quality; vaccine; year cache: cord-103972-kbv9kh6z.txt plain text: cord-103972-kbv9kh6z.txt item: #107 of 303 id: cord-251979-j3mme15e author: Kandeel, Amr title: Morbidity, Mortality, and Seasonality of Influenza Hospitalizations in Egypt, November 2007-November 2014 date: 2016-09-08 words: 4721 flesch: 39 summary: The aims of this study were to (1) assess the proportion of SARI cases having influenza infection in Egypt; (2) examine the types and subtypes of detected influenza viruses in Egypt; (3) compare demographic and clinical characteristics of influenza-positive SARI cases to those of influenza-negative SARI cases in Egypt; (4) quantify influenza deaths and assess influenza mortality risk factors in Egypt; and (5) establish a defined period of influenza seasonality in Egypt. Regardless, patients with influenza infection comprised 19% of total SARI deaths. keywords: cases; data; egypt; hospitalization; infection; influenza; patients; sari; surveillance; years cache: cord-251979-j3mme15e.txt plain text: cord-251979-j3mme15e.txt item: #108 of 303 id: cord-252293-8286lsof author: Suzuki, Motoi title: Effectiveness of inactivated influenza vaccine against laboratory-confirmed influenza pneumonia among adults aged ≥65 years in Japan date: 2018-05-17 words: 4074 flesch: 37 summary: Influenza pneumonia patients were classified as having influenza-associated bacterial pneumonia if their sputum samples were microscopically purulent (i.e., Geckler's classification groups 4 and 5) and tested positive for bacterial pathogens by culture or PCR; otherwise, they were classified as having primary influenza pneumonia. Demographic and clinical characteristics were compared between influenza pneumonia patients (i.e., cases) and noninfluenza pneumonia patients (i.e., controls) (Tables 1 and 2 ). keywords: adults; effectiveness; influenza; patients; pneumonia; study; vaccination; vaccine cache: cord-252293-8286lsof.txt plain text: cord-252293-8286lsof.txt item: #109 of 303 id: cord-252443-lclxrwcm author: Lambe, Teresa title: Novel Viral Vectored Vaccines for the Prevention of Influenza date: 2012-06-19 words: 5988 flesch: 17 summary: H5N1 hemagglutinin induce substantial crossclade protective immunity Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice A preliminary assessment of the efficacy of a T cell-based influenza vaccine, MVA-NP+M1, in humans Attenuation of simian immunodeficiency virus SIVmac239 infection by prophylactic immunization with DNA and recombinant adenoviral vaccine vectors expressing Gag Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunization in non-human primates Prime-boost immunization with adenoviral and modified vaccinia virus Ankara vectors enhances the durability and polyfunctionality of protective malaria CD8(+) T-cell responses Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1 These alternate influenza vaccines offer real promise to deliver viable alternatives to currently deployed vaccines and more importantly may confer long-lasting and universal protection against influenza viral infection. keywords: cell; immunity; influenza; mva; pandemic; protection; responses; vaccination; vaccines; vectors; virus; viruses cache: cord-252443-lclxrwcm.txt plain text: cord-252443-lclxrwcm.txt item: #110 of 303 id: cord-252974-pwx27kdi author: Fornek, Jamie L. title: Use of Functional Genomics to Understand Influenza–Host Interactions date: 2007-08-31 words: 6764 flesch: 33 summary: Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus A question of selfpreservation: Immunopathology in influenza virus infection Orthomyxoviridae: The viruses and their replication Distinct cellular responses differentiating alcohol-and hepatitis C virusinduced liver cirrhosis Immunization of non-human primates with DNA vaccines Retinoic acid-inducible gene I mediates early antiviral response and toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells Analysis of the macaca mulatta transcriptome and the sequence divergence between macaca and human The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2 0 -5 0 oligo (A) synthetase/RNase L pathway Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response Gene expression patterns in blood leukocytes discriminate patients with acute infections Origin and evolution of the 1918 'Spanish' influenza virus hemagglutinin gene Characterization of the 1918 'Spanish' influenza virus neuraminidase gene Characterization of the 1918 'Spanish' influenza virus matrix gene segment Novel origin of the 1918 pandemic influenza virus nucleoprotein gene The rhesus macaque genome sequence informs biomedical and evolutionary analyses Pathogenesis of influenza A (H5N1) virus infection in a primate model Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma Hepatitis C virus and liver disease: Global transcriptional profiling and identification of potential markers Gene expression patterns that correlate with Hepatitis C and early progression to fibrosis in liver transplant recipients Leveraging human genomic information to identify nonhuman primate sequences for expression array development Scientific barriers to developing vaccines against avian influenza viruses Regulating intracellular antiviral aefense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I Influenza virus hemagglutinin cleavage into HA1, HA2: No laughing matter Influenza: The mother of all pandemics Initial genetic characterization of the 1918 'Spanish' influenza virus Functional gene analysis of individual response to challenge of SIVmac239 in M. mulatta PBMC culture Characterization of the reconstructed 1918 Spanish influenza pandemic virus Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: Functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission Virology in the 21st century: Finding function with functional genomics High-density rhesus macaque oligonucleotide microarray design using early-stage rhesus genome sequence information and human genome annotations Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: Role of the innate antiviral immune response Application of functional genomics to the chimeric mouse model of HCV infection: Optimization of microarray protocols and genomics analysis Identification of a specific gene expression pattern associated with HCV-induced pathogenesis in HCV-and HCV/HIV-infected individuals Avian Flu Facts www The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity We thank Tracey Baas, Carole Baskin, Gary Geiss, John Kash, and our many other colleagues past and present that contributed to the studies discussed in this review. For centuries, influenza virus has plagued humankind. keywords: et al; expression; genes; genomics; host; infection; influenza; response; virus cache: cord-252974-pwx27kdi.txt plain text: cord-252974-pwx27kdi.txt item: #111 of 303 id: cord-253049-vm46wq1m author: Rößler, Steve title: Influenza-associated in-hospital mortality during the 2017/2018 influenza season: a retrospective multicentre cohort study in central Germany date: 2020-09-27 words: 1937 flesch: 44 summary: To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/. Erkrankungen durch saisonale Influenzaviren Impact of infectious diseases on population health using incidence-based disability-adjusted life years (DALYs): results from the Burden of Communicable Diseases in Europe study, European Union and European Economic Area countries Bericht zur Epidemiologie der Influenza in Deutschland Assessment of deaths from COVID-19 and from seasonal influenza Clinical characteristics of influenza in season 2017/2018 in a German Emergency Department: a retrospective analysis Intrahospital mortality of influenza patients during the 2017-2018 influenza season: report from a tertiary care hospital in Austria Characteristics and management of patients with influenza in a German hospital during the 2014/2015 influenza season Since it is possible that not every microbiologically confirmed influenza infection was coded at discharge and that microbiological diagnostics were not always performed to ensure the clinically suspected diagnosis, the true number of hospitalized influenza patients could be correspondingly higher than that reported here. keywords: hospital; influenza; mortality; patients cache: cord-253049-vm46wq1m.txt plain text: cord-253049-vm46wq1m.txt item: #112 of 303 id: cord-253083-4mk5u0wg author: Lazarus, Rajeka title: Avian Influenza: Recent Epidemiology, Travel-Related Risk, and Management date: 2014-12-05 words: 5070 flesch: 45 summary: Global influenza program surveillance network evolution of H5N1 avian influenza viruses in Asia Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome Preferential recognition of avian-like receptors in human influenza A H7N9 viruses Structural analysis of the hemagglutinin from the recent 2013 H7N9 influenza virus H5N1 influenza continues to smolder in Southeast Asia since 1997 keywords: avian; cases; china; h5n1; h7n9; human; infection; influenza; patients; poultry; risk; virus cache: cord-253083-4mk5u0wg.txt plain text: cord-253083-4mk5u0wg.txt item: #113 of 303 id: cord-253143-73dsc6q3 author: Tang, Julian W. title: Emerging, Novel, and Known Influenza Virus Infections in Humans date: 2010-08-02 words: 5008 flesch: 38 summary: Perhaps most importantly, the occurrence of these subsequent pandemics gave rise to the concept that such pandemics could and would recur. Pandemic influenza viruses are thought to arise when there is frequent human contact with certain animal species that can be infected with their own specific influenza viruses and when these viruses develop the ability to jump the species barrier to infect humans. Epidemiologically, most deaths occur in infants and the elderly (>65 years old) during the annual influenza epidemics as a result of decreased immunity against influenza virus infection. keywords: cases; h1n1; h5n1; human; infection; influenza; pandemic; patients; virus; viruses cache: cord-253143-73dsc6q3.txt plain text: cord-253143-73dsc6q3.txt item: #114 of 303 id: cord-254117-2ttwaegh author: Priest, Patricia C. title: Thermal Image Scanning for Influenza Border Screening: Results of an Airport Screening Study date: 2011-01-05 words: 4187 flesch: 37 summary: Entry screening to delay local transmission of 2009 pandemic influenza A (H1N1) Revision of the International Health Regulations World Health Organisation Screening for fever by remote-sensing infrared thermographic camera Limitations of forehead infrared body temperature detection for fever screening for severe acute respiratory syndrome Analysis of IR thermal imager for mass blind fever screening Cutaneous infrared thermometry for detecting febrile patients World Health Organization Working Group on International and Community Transmission of SARS (2004) Public health interventions and SARS spread Thermal image scanners to detect fever in airline passengers, Vancouver and Toronto Border screening for SARS Investigation of the optimal assessment of febrile passengers detected by infrared thermal scanning at an international airport Epidemiology of travel-associated pandemic (H1N1) 2009 infection in 116 patients International travels and fever screening during epidemics: a literature review on the effectiveness and potential use of non-contact infrared thermometers Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review Screening for Influenza Infection in International Airline Travellers Manual for the surveillance of vaccine-preventable diseases Diagnostic tests 3: receiver operating characteristic plots Clinical signs and symptoms predicting influenza infection Predicting influenza infections during epidemics with use of a clinical case definition Diagnosis of influenza in the community: relationship of clinical diagnosis to confirmed virological, serologic, or molecular detection of influenza Time lines of infection and disease in human influenza: a review of volunteer challenge studies Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China Clinical diagnostic criteria for isolating patients admitted to hospital with suspected pandemic influenza Entry screening for severe acute respiratory syndrome (SARS) or influenza: policy evaluation We thank the Health Emergency Management Branch, Department of Health and Ageing, Australia for lending us the scanner; Christchurch International Airport Limited, New Zealand Customs Service, and the participating airlines for their cooperation and assistance; and Andrew Strathdee for the laboratory testing. The prevalence of fever is high in case series of patients with confirmed influenza infection [11, 21] , since often one of the criteria that is often used to determine whether testing takes place is the presence of fever. keywords: fever; infection; influenza; itis; screening; study; temperature; travellers cache: cord-254117-2ttwaegh.txt plain text: cord-254117-2ttwaegh.txt item: #115 of 303 id: cord-255181-du6rqc6i author: Louz, Derrick title: Cross‐species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live‐virus vaccines date: 2005-06-29 words: 8024 flesch: 36 summary: Reassortment is another important evolutionary mechanism in RNA viruses with a segmented genome, such as influenza viruses and reoviruses. The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties Pandemic threat posed by avian influenza A viruses Wet markets -a continuing source of severe acute respiratory syndrome and influenza? Quasispecies and the implications for virus persistence and escape The molecular biology of coronaviruses Episodic evolution mediates interspecies transfer of a murine coronavirus Persistent infection promotes cross-species transmissibility of mouse hepatitis virus Receptor homologue scanning functions in the maintenance of MHV-A59 persistence in vitro The N-terminal region of the murine coronavirus spike glycoprotein is associated with the extended host range of viruses from persistently infected murine cells Structure of a major immunogenic site on foot-and-mouth disease virus Molecular basis of pathogenesis of FMDV Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle Cell recognition by foot-and-mouth disease virus that lacks the RGD integrin-binding motif: flexibility in aphthovirus receptor usage Evolution subverting essentiality: dispensability of the cell attachment Arg-Gly-Asp motif in multiply passaged foot-and-mouth disease virus Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor Expansion of host-cell tropism of foot-and-mouth disease virus despite replication in a constant environment Polyomaviridae: the viruses and their replication Evidence for two points of restriction in the expression of adenovirus type 2 in cultured epidermal keratinocytes Isolation of a variant of human adenovirus serotype 2 that multiplies efficiently on monkey cells A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry Infection of Chinese hamster ovary cells by pseudorabies virus Adaptability in herpesviruses: glycoprotein D-independent infectivity of pseudorabies virus Glycoprotein Dindependent infectivity of pseudorabies virus results in an alteration of in vivo host range and correlates with mutations in glycoproteins B and H Three classes of cell surface receptors for alphaherpesvirus entry Modification of human cytomegalovirus tropism through propagation in vitro is associated with changes in the viral genome A DNA transfection system for generation of influenza A virus from eight plasmids A plasmid-based reverse genetics system for influenza A virus Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus Reverse genetics approach towards understanding pathogenesis of H5N1 Hong Kong influenza keywords: adaptation; avian; cell; disease; emergence; gene; host; human; influenza; range; receptor; species; tropism; variants; vectors; viruses cache: cord-255181-du6rqc6i.txt plain text: cord-255181-du6rqc6i.txt item: #116 of 303 id: cord-255807-7goz1agp author: Hak, E. title: Conventional Influenza Vaccination Is Not Associated with Complications in Working-Age Patients with Asthma or Chronic Obstructive Pulmonary Disease date: 2003-04-15 words: 4315 flesch: 32 summary: Because influenza vaccination appeared not to be associated with a clinically relevant reduction in severe morbidity, other measures need to be explored. Although the vaccine does not lead to potentially adverse effects in asthmatics (12) , the few available small-scale studies on the clinical benefits of influenza vaccination among working-age patients with COPD have failed to demonstrate any effectiveness from annual vaccination (6, 13, 14) . keywords: age; asthma; copd; influenza; patients; season; study; vaccination; vaccine cache: cord-255807-7goz1agp.txt plain text: cord-255807-7goz1agp.txt item: #117 of 303 id: cord-256432-53l24le2 author: Yang, Honglin title: A Strategy Study on Risk Communication of Pandemic Influenza: A Mental Model Study of College Students in Beijing date: 2020-09-04 words: 6264 flesch: 43 summary: As shown in Table 5 , 50% of the respondents had a specific information identification ability; 43% of the respondents chose to obtain their information on pandemic risk from the official channels. The content of the whole frame consists of the causes of influenza epidemics, the impact of pandemics, emergency preparedness and strategies of different groups, risk information, and emergency response decisions, as shown in Figure 1 . keywords: communication; concepts; health; influenza; information; interviewee; pandemic; public; respondents; risk; students; virus cache: cord-256432-53l24le2.txt plain text: cord-256432-53l24le2.txt item: #118 of 303 id: cord-257489-ruf4rzxm author: Kee, Sae Yoon title: Influenza vaccine coverage rates and perceptions on vaccination in South Korea date: 2007-06-28 words: 4107 flesch: 40 summary: Demographics, state of influenza vaccination, reasons for vaccination or non-vaccination and perceptions on vaccinations were asked by questionnaire. Having more information on influenza and vaccination as well as doctor's recommendation for vaccination appeared to be the most important modus operandi to encourage influenza vaccination among non-vaccinees. keywords: group; influenza; non; population; risk; vaccination; vaccine cache: cord-257489-ruf4rzxm.txt plain text: cord-257489-ruf4rzxm.txt item: #119 of 303 id: cord-257491-tsdwsyjs author: Cieślak, K. title: Influenza and Influenza-like Viruses in Children in the Epidemic Season 2015/2016 in Poland date: 2016-12-31 words: 1776 flesch: 47 summary: Children are a group particularly affected by influenza virus infection. In the age group of 10-14 years of age, the rate of influenza virus infections (158 cases) was markedly lower than the 601 cases in children aged 0-4 and the 494 cases in children aged 5-9). keywords: age; children; influenza; viruses; years cache: cord-257491-tsdwsyjs.txt plain text: cord-257491-tsdwsyjs.txt item: #120 of 303 id: cord-258021-xhx74vr6 author: Waterer, Grant W. title: Diagnosing Viral and Atypical Pathogens in the Setting of Community-Acquired Pneumonia date: 2016-12-21 words: 4409 flesch: 27 summary: and related species Oseltamivir overuse at a Chicago hospital during the 2009 influenza pandemic and the poor predictive value of influenza-like illness criteria Detection of 2009 pandemic influenza A(H1N1) virus Infection in different age groups by using rapid influenza diagnostic tests Evaluation of indirect fluorescent antibody assays compared to rapid influenza diagnostic tests for the detection of pandemic influenza A (H1N1) pdm09 Sensitivity of rapid influenza antigen tests in the diagnosis of pandemic (H1N1)2009 compared with the standard rRT-PCR technique during the 2009 pandemic in Turkey Comparison of the performance of direct fluorescent antibody staining, a point-of-care rapid antigen test and virus isolation with that of RT-PCR for the detection of novel 2009 influenza A (H1N1) virus in respiratory specimens Accuracy of rapid influenza diagnostic tests: a meta-analysis Randomised controlled trial and health economic evaluation of the impact of diagnostic testing for influenza, respiratory syncytial virus and Streptococcus pneumoniae infection on the management of acute admissions in the elderly and high-risk 18-to 64-year-olds Performance of rapid influenza diagnostic testing in outbreak settings Evaluation of 3 rapid influenza diagnostic tests during the 2012-2013 epidemic: influences of subtype and viral load Comparison of two new generation influenza rapid diagnostic tests with instrument-based digital readout systems for influenza virus detection Current approaches for diagnosis of influenza virus infections in humans 43-47 A recent metaanalysis of 159 published studies of rapid influenza tests found the pooled sensitivity, sensitivity, specificity, and positive and negative predictive values to be 62%, 98%, 34%, and 38%, respectively. keywords: assays; detection; diagnosis; influenza; legionella; pathogens; pcr; pneumonia; testing; tests cache: cord-258021-xhx74vr6.txt plain text: cord-258021-xhx74vr6.txt item: #121 of 303 id: cord-258270-67f5z8et author: He, Biao title: Adenovirus-based vaccines against avian-origin H5N1 influenza viruses date: 2014-12-03 words: 3712 flesch: 22 summary: A antigens Comparative transduction efficiencies of human and nonhuman adenoviral vectors in human, murine, bovine, and porcine cells in culture Bovine adenoviral vectorbased H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus Impact of preexisting adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine Interplay between influenza A virus and the innate immune signaling Intranasal immunization with H5N1 vaccine plus poly I: poly C12U, a toll-like receptor agonist, protects mice against homologous and heterologous virus challenge Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs Mucosal drug delivery: membranes, methodologies, and applications Development of adenoviral vectorbased mucosal vaccine against influenza Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice Genetic immunization in the lung induces potent local and systemic immune responses Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge Mucosal vaccination with recombinant adenovirus encoding nucleoprotein provides potent protection against influenza virus infection Single-dose mucosal immunization with a candidate universal influenza vaccine provides rapid protection from virulent H5N1, H3N2 and H1N1 viruses Research and development of universal influenza vaccines Influenza at the animal-human interface: a review of the literature for virological evidence of human infection with swine or avian influenza viruses other than A(H5N1) Recombinant adeno-associated virus expressing the receptor-binding domain of severe acute respiratory syndrome coronavirus S protein elicits neutralizing antibodies: implication for developing SARS vaccines Priming with rAAV encoding RBD of SARS-CoV S protein and boosting with RBD-specific peptides for T cell epitopes elevated humoral and cellular immune responses against SARS-CoV infection Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors The outbreak of avian influenza A (H7N9) in China: current status and future prospects Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China Genetic tuning of avian influenza A (H7N9) virus promotes viral fitness within different species Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines Comparative efficacy of hemagglutinin, nucleoprotein, and matrix 2 protein gene-based vaccination against H5N1 influenza in mouse and ferret Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1 Partial protection against H5N1 influenza in mice with a single dose of a chimpanzee adenovirus vector expressing nucleoprotein New pre-pandemic influenza vaccines: an egg-and adjuvant-independent human adenoviral vector strategy induces long-lasting protective immune responses in mice A porcine adenovirus with low human seroprevalence is a promising alternative vaccine vector to human adenovirus 5 in an H5N1 virus disease model Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses Pre-clinical evaluation of a replication-competent recombinant adenovirus serotype 4 vaccine expressing influenza H5 hemagglutinin Multi-antigen vaccines based on complex adenovirus vectors induce protective immune responses against H5N1 avian influenza viruses Hence, the development of vaccines against H5N1 influenza viruses is challenging. keywords: adenovirus; avian; h5n1; human; immunity; immunization; influenza; vaccine; viruses cache: cord-258270-67f5z8et.txt plain text: cord-258270-67f5z8et.txt item: #122 of 303 id: cord-258366-fu9b446y author: Couto, Carla R. title: Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project date: 2012-02-06 words: 3290 flesch: 44 summary: The compliance with influenza vaccination is poor among health care workers (HCWs) due to misconceptions about safety and effectiveness of influenza vaccine. We proposed an educational prospective study to demonstrate to HCWs that influenza vaccine is safe and that other respiratory viruses (RV) are the cause of respiratory symptoms in the months following influenza vaccination. keywords: events; hcws; influenza; study; symptoms; vaccination; vaccine cache: cord-258366-fu9b446y.txt plain text: cord-258366-fu9b446y.txt item: #123 of 303 id: cord-258496-h264umt1 author: Jaakkola, Kari title: Decline in temperature and humidity increases the occurrence of influenza in cold climate date: 2014-03-28 words: 4657 flesch: 38 summary: However, to our knowledge; no corresponding studies examining the association between influenza virus infections, temperature and humidity have been conducted in cold climates with subfreezing temperatures. The objective of the present study was to examine the relations between temperature, humidity and the risk of influenza virus infections in a subarctic climatic zone in Northern Finland. keywords: cold; day; humidity; infections; influenza; period; risk; study; temperature cache: cord-258496-h264umt1.txt plain text: cord-258496-h264umt1.txt item: #124 of 303 id: cord-258781-peppszqx author: Ishola, David A. title: Could influenza transmission be reduced by restricting mass gatherings? Towards an evidence-based policy framework date: 2011-08-18 words: 8477 flesch: 44 summary: The type of mass gathering event seems to be of considerable importance in terms of the risk of influenza transmission ( Table 7) . In summary, the type of mass gathering event seems to influence the risk of influenza transmission, key factors being the degree of crowdedness, the event duration and, possibly, whether the event is held indoors or outdoors. keywords: event; evidence; gatherings; hajj; health; influenza; mass; outbreak; pandemic; public; review; studies; study; transmission cache: cord-258781-peppszqx.txt plain text: cord-258781-peppszqx.txt item: #125 of 303 id: cord-260191-0u0pu0br author: Haas, W. title: „Emerging Infectious Diseases“: Dengue-Fieber, West-Nil-Fieber, SARS, Vogelgrippe, HIV date: 2004-05-29 words: 2438 flesch: 44 summary: [19] .Diese bestehen zum einen in der frühzeitigen Identifizierung von Kontaktpersonen und gegebenenfalls in der Absonderung von Personen nach einem festgelegten Schema. In Deutschland werden derzeit Blutund Plasmaspender von der Spende zurückgestellt, wenn sie sich zwischen keywords: als; auf; bei; den; dengue; der; die; durch; eine; für; hiv; infektion; influenza; ist; mit; nach; sars; sich; sind; und; von; werden cache: cord-260191-0u0pu0br.txt plain text: cord-260191-0u0pu0br.txt item: #126 of 303 id: cord-260525-bohv78hi author: Mei, Yang title: Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza date: 2020-07-31 words: 4178 flesch: 45 summary: In this study, we compared the laboratory manifestations of COVID-19 patients admitted to Northwestern Medicine Health System and compared these findings to a cohort of influenza patients. However, COVID-19 patients dropped more rapidly and plummeted to the same levels as influenza patients in the later stages of disease course. keywords: blood; clusters; covid-19; data; influenza; laboratory; parameters; patients cache: cord-260525-bohv78hi.txt plain text: cord-260525-bohv78hi.txt item: #127 of 303 id: cord-260690-h5pjv2dw author: Druce, Julian title: Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002–2003 date: 2004-11-12 words: 3805 flesch: 38 summary: The availability of new classes of drugs active against both influenza A and B viruses , preclinical and clinical trials of drugs targeted at respiratory viruses other than influenza [Hayden et al., 2003; Cianci et al., 2004; Uckun et al., 2004] , and the potential for new vaccines [Power et al., 2001] has encouraged further a shorter diagnostic turnaround time for the detection of respiratory viruses. The results of a 2-year retrospective study of respiratory viruses in more than 4,200 specimens obtained from individuals living in Victoria, Australia are presented. keywords: influenza; patients; pcr; specimens; virus; viruses cache: cord-260690-h5pjv2dw.txt plain text: cord-260690-h5pjv2dw.txt item: #128 of 303 id: cord-260728-4w23kwzu author: Timmermans, Ans title: Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia date: 2016-03-30 words: 7426 flesch: 44 summary: Previous studies have attributed the etiology of acute viral respiratory infections in Cambodia to rhinovirus, respiratory syncytial virus (RSV), parainfluenza virus (PIV), influenza virus A and B, human metapneumovirus (HMPV), bocavirus, adenovirus, enterovirus, and coronavirus Influenza virus efficiently escapes from host antibodies through an accumulation of mutations/single amino acid changes (antigenic drift) at the antigenic sites (epitopes) in surface glycoproteins of the hemagglutinin (HA) gene, and to a lesser extent, neuraminidase (NA) genes [8] . keywords: acid; amino; antigenic; cambodia; changes; gene; influenza; isolates; pcr; samples; sequences; sites; specimens; study; table; virus cache: cord-260728-4w23kwzu.txt plain text: cord-260728-4w23kwzu.txt item: #129 of 303 id: cord-261241-eqf6ame6 author: van Beek, Josine title: Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections date: 2017-08-15 words: 4447 flesch: 46 summary: Influenza virus was not detected in the corresponding recovery samples in this season, suggesting that influenza virus was the actual cause of ILI. key: cord-261241-eqf6ame6 authors: van Beek, Josine; Veenhoven, Reinier H; Bruin, Jacob P; van Boxtel, Renée A J; de Lange, Marit M A; Meijer, Adam; Sanders, Elisabeth A M; Rots, Nynke Y; Luytjes, Willem title: Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections date: 2017-08-15 journal: J Infect Dis DOI: 10.1093/infdis/jix268 sha: doc_id: 261241 cord_uid: eqf6ame6 BACKGROUND: Data on the relative contribution of influenza virus and other respiratory pathogens to respiratory infections in community-dwelling older adults (≥60 years) are needed. keywords: ili; incidence; influenza; participants; pathogens; samples; season; vaccination; virus cache: cord-261241-eqf6ame6.txt plain text: cord-261241-eqf6ame6.txt item: #130 of 303 id: cord-261282-r1nprlne author: CHUGHTAI, A. A. title: The presence of fever in adults with influenza and other viral respiratory infections date: 2016-10-03 words: 3874 flesch: 49 summary: Clinical presentation of influenza in hospitalized patients Fever in the elderly Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study Natural course of fever during influenza virus infection in children Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China Clinical predictors for diagnosing pandemic (H1N1) 2009 and seasonal influenza (H3N2) in fever clinics in Beijing A cluster randomised trial of cloth masks compared to medical masks in healthcare workers A cluster randomized clinical trial comparing fit-tested and non-fit-tested N95 respirators to medical masks to prevent respiratory virus infection in health care workers A randomized clinical trial of three options for N95 respirators and medical masks in health workers Hospital triage system for adult patients using an influenza-like illness scoring system during the 2009 pandemic -Mexico Pandemic Influenza Triage Tools: User Guide Predicting influenza infections during epidemics with use of a clinical case definition Evaluation of clinical case definitions of influenza: detailed investigation of patients during the 1995-1996 epidemic in France Influenzavirus infections in Seattle families, 1975-1979. Influenza infection and disease Differing virulence of H1N1 and H3N2 influenza strains Influenza A and B virus infections in children Differences in clinical features between influenza A H1N1, A H3N2, and B in adult patients Seasonal influenza in adults and children -diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America Signs and symptoms predicting influenza in children: a matched case-control analysis of prospectively collected clinical data Clinical signs and symptoms predicting influenza infection Viral shedding and clinical illness in naturally acquired influenza virus infections Is influenza an influenza-like illness? keywords: cases; children; fever; infections; influenza; study; virus cache: cord-261282-r1nprlne.txt plain text: cord-261282-r1nprlne.txt item: #131 of 303 id: cord-262201-4pab383g author: Wang, Lei title: Chinese herbs in treatment of influenza: A randomized, double-blind, placebo-controlled trial date: 2010-06-22 words: 4313 flesch: 43 summary: The presence and severity of influenza symptoms, including cough, sore throat, nasal obstruction and rhinorrhoea, headache, fatigue, myalgia, thirst and chills, were recorded once daily using a four-point scale (0 absent, 1 mild, 2 moderate, and 3 severe). In our study, the antipyretic effect was apparent within 24 h of Antiwei administration, when influenza symptoms are generally most troublesome. keywords: antiwei; group; influenza; patients; placebo; study; symptoms; treatment; virus cache: cord-262201-4pab383g.txt plain text: cord-262201-4pab383g.txt item: #132 of 303 id: cord-263277-m4too6ob author: Guzmán, Carlos Alberto title: Next Generation Influenza Vaccines: Looking into the Crystal Ball date: 2020-08-21 words: 1924 flesch: 23 summary: Nevertheless, practical considerations, like manufacturing capacity to serve the huge demand for influenza vaccines and considerably higher production costs still represent a bottleneck. The review by Clemens et al. further elaborates on the potential and limitations of harnessing T cells for the development of influenza vaccines [11] . keywords: cells; generation; influenza; vaccination; vaccines cache: cord-263277-m4too6ob.txt plain text: cord-263277-m4too6ob.txt item: #133 of 303 id: cord-263353-4mnsjbib author: Maman, Issaka title: Implementation of Influenza-like illness Sentinel Surveillance in Togo date: 2014-09-20 words: 4525 flesch: 49 summary: Table 3 Distribution of influenza viruses confirmed and ILI patients Influenza A was predominant in 2010 with pandemic influenza A (H1N1) pdm 09 in our study; this observation was similar to that of other countries in West Africa Of the 955 samples, 236 (24.7%) tested positive for influenza viruses; with 136 (14.2%) positive for influenza A and 100 (10.5%) positive for influenza B. The highest influenza positive percentage (30%) was observed in 5–14 years old and patients aged 0–4 and >60 years had the lowest percentage (20%). keywords: h1n1; ili; influenza; pandemic; patients; samples; sentinel; study; surveillance cache: cord-263353-4mnsjbib.txt plain text: cord-263353-4mnsjbib.txt item: #134 of 303 id: cord-263464-fdosch11 author: Nuvey, Francis Sena title: Evaluation of the sentinel surveillance system for influenza-like illnesses in the Greater Accra region, Ghana, 2018 date: 2019-03-14 words: 4095 flesch: 44 summary: Even though the WHO's standards for influenza surveillance alluded to the possibility of resource limitation hindering achievement of all influenza surveillance system objectives, it advocates for influenza surveillance systems capable of collecting the minimum amount of data needed for decision making [5] . Morb Mortal Wkly Rep Strategy to enhance influenza surveillance worldwide A summary of influenza surveillance systems in Australia Influenza surveillance in Europe: establishing epidemic thresholds by the Moving Epidemic Method Establishing seasonal and alert influenza thresholds in Cambodia using the WHO method: implications for effective utilization of influenza surveillance in the tropics and subtropics Exploring a proposed WHO method to determine thresholds for seasonal influenza surveillance World Health Organization. keywords: case; ghana; health; ili; influenza; sentinel; sites; surveillance; system cache: cord-263464-fdosch11.txt plain text: cord-263464-fdosch11.txt item: #135 of 303 id: cord-264335-c2hfh3dq author: Gunson, Rory title: Development of a multiplex real-time RT-PCR that allows universal detection of influenza A viruses and simultaneous typing of influenza A/H1N1/2009 virus date: 2009-10-23 words: 2266 flesch: 41 summary: Although the influenza A/H1N1/2009 virus is likely to become the predominant influenza A type encountered in most countries, seasonal influenza A types may also co-circulate (Kelly et al., 2009) and in some countries sporadic H5N1 infections may still occur (WHO report of Avian influenza, 2009). Determining the subtype of influenza virus is important as it has implications for patient management and infection control (Meijer et al., 2009; Beigel and Bray, 2008; This panel contained examples of seasonal influenza A, H1N1 and H3N2, the influenza A/H1N1/2009 and numerous avian A/H5N1 viruses. keywords: assay; influenza; multiplex; samples; virus cache: cord-264335-c2hfh3dq.txt plain text: cord-264335-c2hfh3dq.txt item: #136 of 303 id: cord-265138-i5m3ax7g author: Wang, Xi-Ling title: Model Selection in Time Series Studies of Influenza-Associated Mortality date: 2012-06-20 words: 4197 flesch: 38 summary: These findings shall help standardize the Poisson modeling approach for influenza disease burden studies. The burden of influenza in East and South-East Asia: a review of the English language literature The Underrecognized Burden of Influenza in Young Children The annual impact of seasonal influenza in the US: Measuring disease burden and costs Estimating influenza-associated deaths in the United States Department of Health, The Government of the Hong Kong Special Administrative Region (2012) Death statistics -by sex and age, cause of death in tabulation list of the international classification of diseases A Practical Guide for Designing and Conducting Influenza Disease Burden Studies Influenza-attributable mortality in Australians aged more than 50 years: a comparison of different modelling approaches Circulating influenza virus, climatic factors, and acute myocardial infarction: a time series study in England and Wales and Hong Kong Excess mortality monitoring in England and Wales during the influenza A(H1N1) 2009 pandemic Air pollutants and health outcomes: Assessment of confounding by influenza Confounding by Season in Ecologic Studies of Seasonal Exposures and Outcomes: Examples From Estimates of Mortality Due to Influenza Estimates of US influenza-associated deaths made using four different methods Influenza-Associated Hospitalization in a Subtropical City Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States Influenza-Associated Mortality in Hong Kong Seasonal effects of influenza on mortality in a subtropical city Validation of Statistical Models for Estimating Hospitalization Associated with Influenza and Other Respiratory Viruses Regression Models for Count Data in R Winter viruses: influenza-and respiratory syncytial virus-related morbidity in chronic lung disease Influenza and the rates of hospitalization for respiratory disease among infants and young children Part 4. keywords: criteria; data; influenza; model; mortality; poisson; study cache: cord-265138-i5m3ax7g.txt plain text: cord-265138-i5m3ax7g.txt item: #137 of 303 id: cord-265751-q1ecpfyg author: Shahani, Lokesh title: Antiviral therapy for respiratory viral infections in immunocompromised patients date: 2017-01-16 words: 10667 flesch: 27 summary: The challenge of respiratory virus infections in hematopoietic cell transplant recipients Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses Antiviral agents for the treatment and chemoprophylaxis of influenza -recommendations of the Advisory Committee on Immunization Practices (ACIP) The seasonal prevalence of influenza infections in immunocompromised patients, including solid-organ transplant and HSCT recipients, closely parallels the community-wide prevalence, with peaks from December to February, with Influenza B activity sometimes seen in April and May [19] . keywords: antiviral; cell; human; infections; influenza; oseltamivir; patients; piv; recipients; resistance; ribavirin; risk; rsv; therapy; transplant; treatment; use; virus; viruses cache: cord-265751-q1ecpfyg.txt plain text: cord-265751-q1ecpfyg.txt item: #138 of 303 id: cord-266100-1rktb6yq author: Darwish, Ilyse title: Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza date: 2012-01-13 words: 2932 flesch: 39 summary: Clinical inhaled nitric oxide research group Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial Inhaled nitric oxide for respiratory failure in preterm infants Inhaled nitric oxide in preterm infants: a systematic review Inhaled nitric oxide for acute hypoxemic respiratory failure in children and adults: a meta-analysis Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Inhaled nitric oxide for acute respiratory distress syndrome and acute lung injury in adults and children: a systematic review with meta-analysis and trial sequential analysis Survey of interventions for the prevention and treatment of acute respiratory distress syndrome Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multi-center study. Severe cases of influenza infection are often associated with multisystem organ failure and hypoxemic respiratory failure, including acute lung injury/acute respiratory distress syndrome (ALI/ARDS) requiring advanced mechanical ventilatory support (24, 25) . keywords: infection; influenza; ino; mice; nitric; oxide; ppm; virus cache: cord-266100-1rktb6yq.txt plain text: cord-266100-1rktb6yq.txt item: #139 of 303 id: cord-266204-ipa017wz author: Poland, G. A. title: Personalized vaccinology: A review date: 2018-08-28 words: 7241 flesch: 27 summary: Dissecting polyclonal vaccine-induced humoral immunity against HIV using systems serology Cytometry by time-offlight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8 + T cell phenotypes Highresolution myogenic lineage mapping by single-cell mass cytometry Metabolic phenotypes of response to vaccination in humans Heterogeneity in vaccine immune response: the role of immunogenetics and the emerging field of vaccinomics Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century Pharmacology, vaccinomics, and the second golden age of vaccinology A systems biology approach to the effect of aging, immunosenescence and vaccine response Genetics and vaccines in the era of personalized medicine The weight of obesity on the human immune response to vaccination Understanding immunosenescence to improve responses to vaccines Vaccine immunogenetics: bedside to bench to population Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology Vaccine discovery and translation of new vaccine technology Systems vaccinology: learning to compute the behavior of vaccine induced immunity Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection Role of HLA, KIR, MICA, and cytokines genes in leprosy Association of variants in BAT1-LTA-TNF-BTNL2 genes within 6p21.3 region show graded risk to leprosy in unrelated cohorts of Indian population Immunogenetics of HIV disease Vaccinomics provides the opportunity to examine not only immune response genes likely to be involved in vaccine response, but also the possibility of identifying the influence of new (uncharacterized) genes on vaccine-induced immunity. keywords: age; cell; development; genes; immunity; immunogenicity; influenza; responses; sex; systems; vaccination; vaccine; vaccinology; vaccinomics; virus cache: cord-266204-ipa017wz.txt plain text: cord-266204-ipa017wz.txt item: #140 of 303 id: cord-268296-w0i7rhru author: Barros, Eliana Nogueira Castro de title: Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition() date: 2015-11-25 words: 4113 flesch: 36 summary: International Congress on Infectious Diseases Options for the control of influenza World Society for Pediatric Infectious Diseases Patterns of influenza infections among different risk groups in Brazil Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults Molecular characterization of influenza B virus outbreak on a cruise ship in Brazil 2012 Applications of a duplex reverse transcription polymerase chain reaction and direct immunofluorescence assay in comparison with virus isolation for detection of influenza A and B Impact of respiratory infections by influenza viruses A and B in pediatrics patients from Federal University of Parana, Brazil Influenza B outbreak on a cruise ship off the Sao Paulo Coast, Brazil Sentinel surveillance of influenza and other respiratory viruses, Brazil Evolutionary pattern of reemerging influenza B/Victoria lineage viruses in Sao Paulo, Brazil, 1996-2012: implications for vaccine composition strategy Etiologia viral das infecç ões respiratórias agudas em população pediátrica no Instituto Fernandes Figueira/FIOCRUZ/RJ Análise filogenética e padronização da técnica de Eletroforese em gel com gradientes desnaturantes (DGGE) para caracterização das linhagens do vírus Influenza B identificadas durante as epidemias de Vigilância de oito vírus respiratórios em amostras clínicas de pacientes pediátricos no sudeste do Brasil The epidemiology and antigenic characterization of influenza viruses isolated in Curitiba, South Brazil Mismatch between vaccine strains and circulating influenza B viruses in different regions of Brazil: 2001-2013. The diagnostic kits currently available identify the influenza A(H1N1)pdm09 viral strain (determined by WHO), influenza A(H3N2), influenza A not subtyped, and influenza B virus. keywords: brazil; data; influenza; lineage; surveillance; vaccination; vaccine; virus; years cache: cord-268296-w0i7rhru.txt plain text: cord-268296-w0i7rhru.txt item: #141 of 303 id: cord-268369-yj7m0n0f author: Wang, Keyang title: Expression and purification of an influenza hemagglutinin—one step closer to a recombinant protein-based influenza vaccine date: 2006-03-15 words: 5707 flesch: 47 summary: For pandemic preparedness, developing and stockpiling rHA influenza vaccines against the present H5N1 strain may be a good option to provide some protection for the first response personnel and the population in the hard-hit areas in the case of a pandemic, and to win the precious time for manufacturing of a more specific influenza vaccine. Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control Serious morbidity and mortality associated with influenza epidemics Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin From lethal virus to life-saving vaccine: developing inactivated vaccines for pandemic influenza Confronting the avian influenza threat: vaccine development for a potential pandemic Probable person-to-person transmission of avian influenza A (H5N1) Cell-based protein vaccines for influenza The role of cell culture vaccines in the control of the next influenza pandemic Next generation flu vaccine boosted by Chiron debacle Preparing for the next pandemic Influvac: a safe Madin Darby Canine Kidney (MDCK) cell culturebased influenza vaccine A Phase I, randomized controlled clinical trial to study the reactogenicity and immunogenicity of a new split influenza vaccine derived from a non-tumorigenic cell line Webster RG. Moreover, two distantly related H1N1 rHA influenza vaccines using the baculovirusinsect cell expression system have also been demonstrated to partially protect mice against the lethal challenge of a recombinant 1918 pandemic influenza virus [24] . keywords: buffer; cells; influenza; insect; new; pandemic; process; protein; purification; rha; vaccine; virus cache: cord-268369-yj7m0n0f.txt plain text: cord-268369-yj7m0n0f.txt item: #142 of 303 id: cord-268593-rvxxv1dn author: Wang, Mingyang title: Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus date: 2015-07-28 words: 10182 flesch: 37 summary: Established cell line sensitive to influenza C virus Host range restriction and pathogenicity in the context of influenza pandemic Characterization of the cordlike structures emerging from the surface of influenza C virusinfected cells The ability of influenza C virus to generate cord-like structures is influenced by the gene coding for M protein Properties of influenza C virus grown in cell culture The cytoplasmic tail of the influenza C virus glycoprotein HEF negatively affects transport to the cell surface Demonstration of hemolytic and fusion activities of influenza C virus Distribution of the antibody to influenza C virus in dogs and pigs in Yamagata Prefecture A seven plasmid-based system for the rescue of influenza C virus Influenza C virus CM2 integral membrane glycoprotein is produced from a polypeptide precursor by cleavage of an internal signal sequence Cell surface expression of biologically active influenza C virus HEF glycoprotein expressed from cDNA Genetic reassortment of influenza C viruses in man Structure of the influenza C glycoprotein gene as determined from cloned DNA The catalytic triad of the influenza C virus glycoprotein HEF esterase: characterization by site-directed mutagenesis and functional analysis 5' and 3' terminal nucleotide sequences of the RNA genome segments of influenza virus Influenza C virus uses 9-O-acetyl-N-acetylneuraminic acid as a high affinity receptor determinant for attachment to cells Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza C virus Influenza virus assembly and budding Influenza virus M2 protein mediates ESCRT-independent membrane scission Fatty acids on the A/USSR/77 influenza virus hemagglutinin facilitate the transition from hemifusion to fusion pore formation Influenza C virus high seroprevalence rates observed in 3 different population groups Sialic acids as receptor determinants for coronaviruses Disulfide bond formation during the folding of influenza virus hemagglutinin Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin Genetic diversity and evolution of the influenza C virus Deacylation of the hemagglutinin of influenza A/Aichi/2/68 has no effect on membrane fusion properties The influenza C virus CM2 protein can alter intracellular pH, and its transmembrane domain can substitute for that of the influenza A virus M2 protein and support infectious virus production Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease Effects of various proteases on the glycoprotein composition and the infectivity of influenza C virus A single point mutation of the influenza C virus glycoprotein (HEF) changes the viral receptor-binding activity Post-translational folding of the influenza C virus glycoprotein HEF: defective processing in cells expressing the cloned gene Intrinsic temperature sensitivity of influenza C virus hemagglutininesterase-fusion protein Studies on survival of influenza virus between epidemics and antigenic variants of the virus A further note on 1233 influenza C virus Avian influenza: a review Distribution of sialic acid receptors and influenza A virus of avian and swine origin in experimentally infected pigs Influence of acylation sites of influenza B virus hemagglutinin on fusion pore formation and dilation Palmitoylation of virus proteins Timing of palmitoylation of influenza virus hemagglutinin Association of influenza virus proteins with membrane rafts The hemagglutinating glycoproteins of influenza B and C viruses are acylated with different fatty acids Site-specific mutagenesis identifies three cysteine residues in the cytoplasmic tail as acylation sites of influenza virus hemagglutinin Cytoplasmic tail length influences fatty acid selection for acylation of viral glycoproteins Palmitoylation of influenza virus proteins The influenza C virus glycoprotein (HE) exhibits receptor-binding (hemagglutinin) and receptor-destroying (esterase) activities Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses Detection of influenza C virus by using an in situ esterase assay Acylationmediated membrane anchoring of avian influenza virus hemagglutinin is essential for fusion pore formation and virus infectivity The fine structure of influenza A, B and C viruses Prevalence of antibody to influenza C virus among pigs in Hyogo Prefecture Evidence that the matrix protein of influenza C virus is coded for by a spliced mRNA Comparison of the three large polymerase proteins of influenza A, B, and C viruses Distribution of influenza C virus infection in dogs and pigs in Bavaria Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution X-ray crystallographic determination of the structure of the influenza C virus haemagglutinin-esterase-fusion glycoprotein Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins Modification of sialic acids by 9-O-acetylation is detected in human leucocytes using the lectin property of influenza C virus Mutations at palmitylation sites of the influenza virus hemagglutinin affect virus formation The work in the authors' laboratory on influenza virus is supported by the German Research Foundation (SFB 740, TP C3). keywords: acid; amino; c virus; esterase; et al; fusion; hef; hemagglutinin; influenza; influenza virus; membrane; protein; receptor; residues; structure; virus; viruses cache: cord-268593-rvxxv1dn.txt plain text: cord-268593-rvxxv1dn.txt item: #143 of 303 id: cord-268693-td6kvmlq author: Martins, Leila Droprinchinski title: How socio-economic and atmospheric variables impact COVID-19 and Influenza outbreaks in tropical and subtropical regions of Brazil date: 2020-09-16 words: 4437 flesch: 40 summary: The CFR values presented in Table 1 are higher when compared to statistics reported to other countries (Banerjee et al., 2020; Verity et al., 2020) . The fraction of elderly, one additional information captured by the HDI, is also an important risk factor, as already noticed and documented by Health Systems around the world (Banerjee et al., 2020; Yi-ru Wang, 2020; Verity et al., 2020) . keywords: climate; covid-19; et al; humidity; influenza; temperature; variables cache: cord-268693-td6kvmlq.txt plain text: cord-268693-td6kvmlq.txt item: #144 of 303 id: cord-269324-zh1a3gwh author: Mubareka, Samira title: Human Genes and Influenza date: 2008-01-01 words: 1824 flesch: 30 summary: Interestingly, better survival rates have been demonstrated for TLR3 knockout mice than for wild-type mice, despite the TLR3 knockout mice having higher lung virus titers after influenza virus infection [14] . All of these genes would be excellent candidates for an analysis to iden-tify determinants of severity of disease after influenza virus infection. keywords: factors; genes; infection; influenza; virus cache: cord-269324-zh1a3gwh.txt plain text: cord-269324-zh1a3gwh.txt item: #145 of 303 id: cord-269623-9pxdeva3 author: Nicholson, Karl G title: Influenza date: 2003-11-22 words: 9809 flesch: 36 summary: Of the three types of influenza viruses-A, B, and C-only types A and B cause widespread outbreaks. In southern China, influenza viruses circulate throughout the year. keywords: avian; children; efficacy; h5n1; human; illness; influenza; neuraminidase; oseltamivir; pandemic; people; treatment; vaccination; vaccines; virus; viruses; years; zanamivir cache: cord-269623-9pxdeva3.txt plain text: cord-269623-9pxdeva3.txt item: #146 of 303 id: cord-270703-c8mv2eve author: Christensen, Paul A title: Real-time Communication With Health Care Providers Through an Online Respiratory Pathogen Laboratory Report date: 2018-11-30 words: 1680 flesch: 43 summary: In addition, clinical laboratories should routinely monitor local influenza data to determine if epidemics are occurring, if continued testing is necessary, or if patients can be treated based on positive symptoms alone [2, 3] . Open Forum Infect Dis DOI: 10.1093/ofid/ofy322 sha: doc_id: 270703 cord_uid: c8mv2eve We implemented a real-time report to distribute respiratory pathogen data for our 8-hospital system to anyone with an Internet connection and a web browser. keywords: data; influenza; report; system; time cache: cord-270703-c8mv2eve.txt plain text: cord-270703-c8mv2eve.txt item: #147 of 303 id: cord-270772-zshjrc87 author: To, Kelvin Kai-Wang title: Host genes and influenza pathogenesis in humans: an emerging paradigm date: 2015-06-14 words: 4128 flesch: 27 summary: In a 7-year-old girl without known immunodeficiency who suffered from severe influenza virus infection, IRF7 mutation was identified using whole exome sequencing [40 ] . Interleukin-10 (IL-10) is persistently elevated in patients with severe influenza virus infection [9] . keywords: cells; genes; host; human; infection; influenza; mice; pandemic; patients; study; virus cache: cord-270772-zshjrc87.txt plain text: cord-270772-zshjrc87.txt item: #148 of 303 id: cord-270910-xb746mv5 author: Lebrun-Harris, Lydie A. title: Influenza vaccination among U.S. pediatric patients receiving care from federally funded health centers date: 2020-07-24 words: 5239 flesch: 31 summary: Third, although influenza vaccines are recommended for infants starting at 6 months, it was not possible to examine vaccination among health center patients younger than 2 years because of how age was coded in the dataset; therefore we were unable to obtain estimates of influenza vaccination for this age group. What is a Health Center New Census Data Show Differences Between Urban and Rural Populations Number of children Key facts about the number of children How to improve influenza vaccination rates in the U.S. J Prevent Med Public Health = Yebang Uihakhoe chi Flu-Floppers: Factors Influencing Families' Fickle Flu Vaccination Patterns Vaccine hesitancy and influenza beliefs among parents of children requiring a second dose of influenza vaccine in a season: An American Academy of Pediatrics (AAP) Pediatric Research in Office Settings (PROS) study Partnering with parents to remove barriers and improve influenza immunization rates for young children An assessment of parental knowledge, attitudes, and beliefs regarding influenza vaccination What is 'confidence' and what could affect it? keywords: care; centers; children; health; influenza; patients; pediatric; survey; vaccination; vaccine cache: cord-270910-xb746mv5.txt plain text: cord-270910-xb746mv5.txt item: #149 of 303 id: cord-271172-y48dovux author: Potter, Christopher William title: Chapter 25 Respiratory tract viruses date: 1998-12-31 words: 8621 flesch: 32 summary: Infection is primarily of the epithelial cells of the oropharynx, and via the complement receptor CD21: virus infection from these cells spreads to P-lymphocytes where a few cells undergo lytic infection while the majority support a latent infection that leads to cell proliferation. In contrast, virus infections have been associated with ECG and EEG changes; some unconfirmed observations of virus antigen in brain and heart tissue have been published; and infection can be associated with viral encephalitis, particularly among children. keywords: cause; cells; children; days; disease; infection; influenza; patients; pneumonia; symptoms; tract; treatment; virus; viruses; years cache: cord-271172-y48dovux.txt plain text: cord-271172-y48dovux.txt item: #150 of 303 id: cord-272655-qeojdpez author: Remolina, Yuly Andrea title: Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia date: 2015-11-17 words: 4310 flesch: 37 summary: Furthermore, current challenges in the epidemiological surveillance of viral respiratory tract infections include the early and fast identification of aetiological agents, especially at the beginnings of outbreaks, and the optimal and timely management of a large number of samples [14] . Results from a prospective, population-based study Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults Bacterial complications of respiratory tract viral illness: a comprehensive evaluation Estimates of mortality attributable to influenza and RSV in the United States during 1997-2009 by influenza type or subtype, age, cause of death, and risk status Roles of humidity and temperature in shaping influenza seasonality Epidemiology and seasonality of respiratory tract virus infections in the tropics Utilization of nucleic acid amplification assays for the detection of respiratory viruses Comparative evaluation of effectiveness of IAVchip DNA microarray in influenza A diagnosis Microorganisms in respiratory tract of patients diagnosed with atypical pneumonia: results of a research based on the use of reverse transcription polymerase chain reaction (RT-PCR) DNA microarray method and enzyme-linked immunosorbent assay The clinical utility of a near patient care rapid microarray-based diagnostic test for influenza and respiratory syncytial virus infections in the pediatric setting Multi-center evaluation of the adenovirus R-gene US assay for the detection of adenovirus in respiratory samples Antibiotic prescribing in ambulatory care settings for adults with colds, upper respiratory tract infections, and bronchitis Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections A role for Streptococcus pneumoniae in virus-associated pneumonia keywords: cases; days; hospital; infections; influenza; patients; pneumonia; study; virus cache: cord-272655-qeojdpez.txt plain text: cord-272655-qeojdpez.txt item: #151 of 303 id: cord-273147-24fkaqlz author: Brownstein, John S title: Empirical Evidence for the Effect of Airline Travel on Inter-Regional Influenza Spread in the United States date: 2006-09-12 words: 6352 flesch: 42 summary: In contrast, data from the 121 Cities Mortality Reporting System provide a more current time series of influenza mortality that is available for examining the recent fluctuations in human travel, including evaluating the effect of the 2001-2002 flight reduction on influenza spread. key: cord-273147-24fkaqlz authors: Brownstein, John S; Wolfe, Cecily J; Mandl, Kenneth D title: Empirical Evidence for the Effect of Airline Travel on Inter-Regional Influenza Spread in the United States date: 2006-09-12 journal: PLoS Med DOI: 10.1371/journal.pmed.0030401 sha: doc_id: 273147 cord_uid: 24fkaqlz BACKGROUND: The influence of air travel on influenza spread has been the subject of numerous investigations using simulation, but very little empirical evidence has been provided. keywords: airline; data; influenza; mortality; pandemic; peak; season; spread; time; travel cache: cord-273147-24fkaqlz.txt plain text: cord-273147-24fkaqlz.txt item: #152 of 303 id: cord-273907-58jufmx7 author: Shen, Kun-Ling title: Global Pediatric Pulmonology Alliance recommendation to strengthen prevention of pediatric seasonal influenza under COVID-19 pandemic date: 2020-09-13 words: 1726 flesch: 38 summary: Countries and regions with ample resources should implement free influenza vaccination in child care centers, kindergartens and schools, so as to increase the coverage rate of influenza vaccination among the pediatric population [16] . These organizations vigorously advocate influenza vaccination as the primary measure for pandemic prevention and control, so as to minimize the interference of an influenza epidemic during the prevention and control of the COVID-19 pandemic situation. keywords: children; covid-19; health; influenza; vaccination; vaccine cache: cord-273907-58jufmx7.txt plain text: cord-273907-58jufmx7.txt item: #153 of 303 id: cord-275150-d63noia4 author: Ye, Chuchu title: Viral pathogens among elderly people with acute respiratory infections in Shanghai, China: Preliminary results from a laboratory‐based surveillance, 2012‐2015 date: 2017-07-06 words: 1754 flesch: 36 summary: influenza virus, public policy, respiratory track Acute respiratory infections (ARIs) are the most common illnesses worldwide. The positive percentage of influenza virus presented two seasonal peaks, with a primary peak in the winter (January-February) and a secondary peak in the summer (July-August), with the positive percentage of 36.09% and 20.13% respectively. keywords: aris; infections; influenza; patients; virus cache: cord-275150-d63noia4.txt plain text: cord-275150-d63noia4.txt item: #154 of 303 id: cord-275355-4izc5jxs author: Hayden, Frederick title: Transmission of Avian Influenza Viruses to and between Humans date: 2005-10-15 words: 2250 flesch: 30 summary: Documentation of seropositivity for avian influenza viruses in farm workers is not a new finding [3] , and previous studies have assessed human susceptibility by intranasal inoculation of selected avian influenza viruses [4] . Transmission of avian influenza virus likely encompasses these routes, as well as others. keywords: avian; h5n1; human; influenza; transmission; viruses cache: cord-275355-4izc5jxs.txt plain text: cord-275355-4izc5jxs.txt item: #155 of 303 id: cord-275462-7a55odok author: Journeay, W Shane title: Pandemic influenza: implications for occupational medicine date: 2009-06-23 words: 4310 flesch: 40 summary: key: cord-275462-7a55odok authors: Journeay, W Shane; Burnstein, Matthew D title: Pandemic influenza: implications for occupational medicine date: 2009-06-23 journal: J Occup Med Toxicol DOI: 10.1186/1745-6673-4-15 sha: doc_id: 275462 cord_uid: 7a55odok This article reviews the biological and occupational medicine literature related to H5N1 pandemic influenza and its impact on infection control, cost and business continuity in settings outside the health care community. However, when the process is poorly understood, as is the case with pandemic influenza, determining the most appropriate prevention and mitigation strategy is more complex. keywords: avian; care; disease; employees; h5n1; health; influenza; pandemic; transmission cache: cord-275462-7a55odok.txt plain text: cord-275462-7a55odok.txt item: #156 of 303 id: cord-275814-seirbkiq author: Tuncer, Necibe title: Effect of air travel on the spread of an avian influenza pandemic to the United States date: 2014-03-31 words: 6688 flesch: 56 summary: Strategies for containing an emerging influenza pandemic in Southeast Asia Fields Virology, Lippincott-Raven Food and Agriculture Organization Mitigation strategies for pandemic influenza in the United States Assessing the impact of airline travel on the geographic spread of pandemic influenza Prevention of avian influenza epidemic: What policy should we choose Avian-human influenza epidemic model Avian flu pandemic: Can we prevent it Avian-human influenza epidemic model with diffusion Containing pandemic influenza at the source An avian influenza model and its fit to human avian influenza cases Avian flu: Modeling and implications for control Pandemic influenza: risk of multiple introductions and the need to prepare for them The effect of global travel on the spread of SARS Modeling seasonality in avian influenza H5N1 Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission World Health Organization, Influenza at the Human-Animal Interface World Health Organization, Influenza at the Human-Animal Interface, Summary and Assessment as of World Health Organization, Overview of the Emergence of and Characteristics of the Avian Influenza A (H7N9) virus Real air travel data is used to model the disease spread by individuals who are susceptible to or are infected with pandemic avian influenza. keywords: city; influenza; model; pandemic; rate; travel cache: cord-275814-seirbkiq.txt plain text: cord-275814-seirbkiq.txt item: #157 of 303 id: cord-276015-id15u3br author: Beran, Jiří title: Inosine pranobex is safe and effective for the treatment of subjects with confirmed acute respiratory viral infections: analysis and subgroup analysis from a Phase 4, randomised, placebo-controlled, double-blind study date: 2016-11-07 words: 6094 flesch: 41 summary: Thus, the efficacy of inosine pranobex was improved in nonobese subjects compared with obese subjects, probably because the immune system in the former is more capable of defending against pathogens and is not negatively affected by obesity-related complications. The safety analysis demonstrated that inosine pranobex treatment was well tolerated, and no major differences in safety profiles were observed between treatment groups. keywords: age; group; influenza; inosine; inosine pranobex; placebo; pranobex; study; subjects; treatment; years cache: cord-276015-id15u3br.txt plain text: cord-276015-id15u3br.txt item: #158 of 303 id: cord-276037-0bxwv6b7 author: Bias, Harald title: Self-reported adverse reactions in 4337 healthcare workers immunizations against novel H1N1 influenza date: 2011-08-17 words: 2129 flesch: 46 summary: Prevalence of latent tuberculosis infection among health care workers in a hospital for pulmonary diseases Treatment and vaccines for severe acute respiratory syndrome Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus Reassortment patterns in Swine influenza viruses Historical perspective-Emergence of influenza A (H1N1) viruses World Health Organization declares A (H1N1) influenza pandemic Trivalent inactivated influenza vaccine safety in children: assessing the contribution of telephone encounters Misperceptions regarding influenza vaccine safety for individuals with chronic medical illness Safety of trivalent inactivated influenza vaccines in adults: background for pandemic influenza vaccine safety monitoring Active influenza vaccine safety surveillance: potential within a healthcare claims environment Feasibility of telemonitoring for active surveillance of influenza vaccine safety in the primary care setting in The Netherlands Swine flu agitates the adjuvant debate Healthcare workers should get top priority for vaccination against A/H1N1 flu, WHO says Novel H1N1 influenza and respiratory protection for health care workers Safety and immunogenicity of a 2009 pandemic influenza A H1N1 vaccine when administered alone or simultaneously with the seasonal influenza vaccine for the 2009-10 influenza season: a multicentre, randomised controlled trial Influenza A (H1N1) 2009: The safety of influenza vaccine is in the focus of research since many years [13] keywords: h1n1; influenza; pandemic; safety; vaccination; vaccine cache: cord-276037-0bxwv6b7.txt plain text: cord-276037-0bxwv6b7.txt item: #159 of 303 id: cord-276577-06boh550 author: Schanzer, Dena L. title: Estimating Sensitivity of Laboratory Testing for Influenza in Canada through Modelling date: 2009-08-18 words: 3961 flesch: 33 summary: While the null value for b 5 is zero, which indicates no statistical association between the number of influenza positive tests and the number of influenza negative tests, the corresponding null value for sensitivity is 1. The weekly number of influenza negative tests estimated to be falsely negative is given by b 5 InflA w +b 6 InflB w . keywords: influenza; model; number; sensitivity; testing; tests; viruses cache: cord-276577-06boh550.txt plain text: cord-276577-06boh550.txt item: #160 of 303 id: cord-277217-jh4qmoso author: Ortiz, Justin R. title: Clinical care for severe influenza and other severe illness in resource‐limited settings: the need for evidence and guidelines date: 2013-08-27 words: 3671 flesch: 31 summary: Euro surveillance: bulletin europeen sur les maladies transmissibles Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study Research during public health crises: a systematic review of severe pandemic influenza management Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection Early corticosteroids in severe influenza A/H1N1 pneumonia and acute respiratory distress syndrome Corticosteroid therapy in intensive care unit patients with PCR-confirmed influenza A(H1N1) infection in Finland Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1) Extracorporeal membrane oxygenation for severe influenza A (H1N1) acute respiratory distress syndrome: a prospective observational comparative study Epidemiology and etiology of childhood pneumonia Viral etiology of severe pneumonia among Kenyan infants and children Influenza is a major contributor to childhood pneumonia in a tropical developing country Human metapneumovirus-associated lower respiratory tract infections among hospitalized human immunodeficiency virus type 1 (HIV-1)-infected and HIV-1-uninfected African infants Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis Mortality associated with influenza and respiratory syncytial virus in the United States Elevated influenza-related excess mortality in South African elderly individuals Influenza-related mortality among adults aged 25-54 years with AIDS in South Africa and the United States of america Incidence and outcomes of acute lung injury The epidemiology of sepsis in the United States from 1979 through 2000 Treatment of sepsis Critical care and the global burden of critical illness in adults The Acute Respiratory Distress Syndrome Network. Despite the absence of sophisticated equipment and abundant resources, including ICUs, it is likely that many lives in resource-limited settings can be saved by promoting the basic tenets of severe illness management. keywords: care; h1n1; illness; influenza; management; pandemic; resource; settings cache: cord-277217-jh4qmoso.txt plain text: cord-277217-jh4qmoso.txt item: #161 of 303 id: cord-277970-sb1wjd3b author: Kang, Qianli title: Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines date: 2020-10-14 words: 2836 flesch: 38 summary: cusimano & hett and sensitive cell lines with the serum pharmacology method and identification by UPLC-TOF-MS A mechanism underlying attenuation of recombinant influenza A viruses carrying reporter genes A cell-based high-throughput approach to identify inhibitors of influenza A virus Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models Inhibition of endosomal fusion activity of influenza virus by rheum tanguticum (da-huang) Ten TCM fractions were identified to possess antiviral activities against influenza virus. keywords: extracts; figure; fractions; influenza; screening; tcm; virus cache: cord-277970-sb1wjd3b.txt plain text: cord-277970-sb1wjd3b.txt item: #162 of 303 id: cord-278508-h145cxlp author: Streng, Andrea title: Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13 date: 2015-12-18 words: 4712 flesch: 37 summary: Furthermore, we described the clinical characteristics of influenza PICU patients and compared patients with severe A(H1N1)pdm09 disease between the post-pandemic seasons. The minimum incidence of influenza-associated PICU admissions per 100,000 children <17 years of age was calculated for each season based on the observed number of influenza PICU patients with a residential address in Bavaria. keywords: a(h1n1)pdm09; age; children; incidence; influenza; pandemic; patients; picu; season cache: cord-278508-h145cxlp.txt plain text: cord-278508-h145cxlp.txt item: #163 of 303 id: cord-278554-rg92gcc6 author: Aoyagi, Yumiko title: Healthcare workers' willingness to work during an influenza pandemic: a systematic review and meta-analysis date: 2015-04-23 words: 4577 flesch: 33 summary: Although variable in severity, 1,2 one consistent feature of pandemic influenza is a surge in demand for health care. Importantly, one message arising from assessments of pandemic planning activities prior to the 2009-10 pandemic was that whilst national level pandemic planning was generally successful, the level of planning at local level was insufficient, including training on pandemic influenza for HCWs. keywords: factors; hcws; health; influenza; meta; pandemic; risk; studies; willingness; work; workers cache: cord-278554-rg92gcc6.txt plain text: cord-278554-rg92gcc6.txt item: #164 of 303 id: cord-278807-p1crrb8n author: Antón, A. title: Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain date: 2016-03-02 words: 3104 flesch: 36 summary: Phylogenetic and molecular characterizations of viral haemagglutinin, partial neuraminidase and matrix 2 proteins were performed from a representative sampling of influenza viruses. During these six consecutive seasons other RV than influenza viruses were mainly detected during the cold months, often just before and after the seasonal influenza epidemics ( Fig. 2) , with scarce circulation during the inter-seasonal periods. keywords: influenza; pandemic; sequences; strains; vaccine; viruses cache: cord-278807-p1crrb8n.txt plain text: cord-278807-p1crrb8n.txt item: #165 of 303 id: cord-279615-yne753y6 author: Jelley, Lauren title: Influenza C infections in Western Australia and Victoria from 2008 to 2014 date: 2016-07-23 words: 1818 flesch: 37 summary: Influenza Other Respir Viruses Epidemiological information regarding the periodic epidemics of influenza C virus in Japan (1996-2013) and the seroprevalence of antibodies to different antigenic groups Prospective study of influenza C in hospitalized children Detection of influenza C virus but not influenza D virus in Scottish respiratory samples Specific viruses detected in nigerian children in association with acute respiratory disease Influenza C virus infection in military recruits-symptoms and clinical manifestation Influenza C virus and human metapneumovirus infections in hospitalized children with lower respiratory tract illness Isolation and characterization of influenza C viruses in the Philippines and Japan Influenza C virus high seroprevalence rates observed in 3 different population groups Effectiveness of trivalent flu vaccine in healthy young children The detection and multiplication of influenza C virus in tissue culture New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 The dominant antigenic group of influenza C infections changed from c/Sao Paulo/378/82-lineage to c/Kanagawa/1/76-lineage in Yamagata Isolation of influenza C virus recombinants Hemagglutinin-esterase-fusion (HE) protein of influenza C virus Phylogenetic analysis and seroprevalence of influenza C virus in Mie Prefecture, Japan in 2012 Influenza C virus-associated community-acquired pneumonia in children. Influenza C viruses were detected sporadically in two widely in the WAIVE study, 11.1% vs 16.8%, respectively. keywords: children; influenza; samples; viruses cache: cord-279615-yne753y6.txt plain text: cord-279615-yne753y6.txt item: #166 of 303 id: cord-280218-zwjrcaab author: He, Xiao-Song title: Distinct Patterns of B-Cell Activation and Priming by Natural Influenza Virus Infection Versus Inactivated Influenza Vaccination date: 2014-10-21 words: 4822 flesch: 27 summary: A live attenuated influenza A (H5N1) vaccine induces long-term immunity in the absence of a primary antibody response Tolerance induction of IgG+ memory B cells by T cell-independent type II antigens Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans Induction of ICOS-+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital Efficacy of repeated annual immunization with inactivated influenza virus vaccines over a five year period The plea against annual influenza vaccination? For comparison of immune priming by influenza virus infection versus IIV immunization, because the 2 data sets to be compared had some participants in common, comparisons of means used perturbation resampling [18] with bias correction [19] to estimate P values. keywords: a(h1n1)pdm09; cell; iiv; immunization; infection; influenza; response; vaccine; virus cache: cord-280218-zwjrcaab.txt plain text: cord-280218-zwjrcaab.txt item: #167 of 303 id: cord-281228-8kqohdcr author: Li, Xin title: Influenza immunization among Chinese seniors: Urgent calling for improving vaccination coverage, education, and research date: 2020-03-27 words: 1460 flesch: 32 summary: World Health Organization website Estimates of global seasonal influenza-associated respiratory mortality: a modelling study Influenza (flu) Influenzaassociated hospitalizations in the United States The annual impact of seasonal influenza in the US: measuring disease burden and costs Estimating influenza vaccine effectiveness: evolution of methods to better understand effects of confounding in older adults Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled Risk of myocardial infarction and stroke after acute infection or vaccination Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults Impact of influenza vaccination on seasonal mortality in the US elderly population Mortality associated with influenza and respiratory syncytial virus in the United States Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review Effectiveness of influenza vaccine in the community-dwelling elderly Frailty is associated with impairment of vaccine-induced antibody response and increase in post-vaccination influenza infection in community-dwelling older adults The aging tsunami and senior healthcare development in China Using the Immunization Information System to determine vaccination coverage rates among children aged 1-7 years: a report from Zhejiang Province, China An overview of coverage of BCG vaccination and its determinants based on data from the coverage survey in Zhejiang Province Overview of influenza vaccination policy in Beijing, China: current status and future prospects Meeting report: the pathway to a universal influenza vaccine Telomere length as an indicator of the robustness of B and T cell response to influenza immunization in older adults Understanding immunosenescence to improve responses to vaccines Chronic low-grade inflammatory phenotype (CLIP) and senescent immune dysregulation Aging, sex, inflammation, frailty, and CMV and HIV Infections Sex and gender differences in the outcomes of vaccination over the life course Allogeneic mesenchymal stem cell therapy: a regenerative medicine approach to geroscience Allogeneic mesenchymal stem cell therapy improves immune response to influenza vaccination in aging frailty: preliminary results from HERA trial. 15 In recent years, a new generation of influenza vaccines, including high-dose (HD) and adjuvanted ones, have been approved by the US Food and Drug Administration (FDA) for older adults in the United States and elsewhere, in addition to the standard dose trivalent inactivated influenza vaccine (IIV3). keywords: adults; influenza; research; vaccination; vaccine cache: cord-281228-8kqohdcr.txt plain text: cord-281228-8kqohdcr.txt item: #168 of 303 id: cord-282085-r3w90vg8 author: Epperly, D. E. title: COVID-19 Viral Loads, Environment, Ventilation, Masks, Exposure Time, And Severity : A Pragmatic Guide Of Estimates date: 2020-10-05 words: 5520 flesch: 49 summary: https://doi.org/10.1101/2020.10.03.20206110 doi: medRxiv preprint It has been shown in various challenge studies as noted earlier that case severity tends to increase with increasing initial exposure viral load. Future studies could improve this adjustment value. keywords: air; challenge; covid-19; estimates; exposure; illness; influenza; patients; study cache: cord-282085-r3w90vg8.txt plain text: cord-282085-r3w90vg8.txt item: #169 of 303 id: cord-282140-teplpmi6 author: Horm, Srey Viseth title: Intense circulation of A/H5N1 and other avian influenza viruses in Cambodian live-bird markets with serological evidence of sub-clinical human infections date: 2016-07-20 words: 5456 flesch: 43 summary: Influenza Other Respir A high diversity of Eurasian lineage low pathogenicity avian influenza A viruses circulate among wild birds sampled in Egypt Dynamic of H5N1 virus in Cambodia and emergence of a novel endemic sub-clade MEGA5: Molecular Evolutionary Genetics Analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Influenza A (H5N1) virus surveillance at live poultry markets, Cambodia Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong Identifying live bird markets with the potential to act as reservoirs of avian influenza A (H5N1) virus: a survey in northern Viet Nam and Cambodia Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi Influenza virus (H5N1) in live bird markets and food markets Circulation of avian influenza H5N1 in live bird markets in Egypt Environmental sampling for avian influenza virus A (H5N1) in live-bird markets Detection of influenza A virus in live bird markets in Kenya Detection of HPAI H5N1 viruses in ducks sampled from live bird markets in Vietnam Avian influenza H5N1 surveillance and its dynamics in poultry in live bird markets Further monitoring of the circulation of influenza A/H5N1 in Cambodian LBMs and research into the mechanisms associated with human cases is warranted. ); and the World Health Organization country office in Cambodia (Grant NO Ecology of avian influenza viruses in a changing world Ecology of avian influenza virus in birds A new avian influenza virus from feral birds in the USSR: recombination in nature? Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States The virulence of the 1918 pandemic influenza virus: unraveling the enigma Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus Molecular epidemiology of clade 1 influenza A viruses (H5N1), southern Indochina peninsula Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A (H5N1) viruses detected in Cambodia in 2013 Avian influenza (195): Cambodia (BA, SI) H5N1, poultry, OIE. keywords: aivs; avian; h5n1; h9n2; human; influenza; markets; poultry; samples; study; virus; viruses cache: cord-282140-teplpmi6.txt plain text: cord-282140-teplpmi6.txt item: #170 of 303 id: cord-283537-49ic7p3u author: Chong, Ka Chun title: Identifying Meteorological Drivers for the Seasonal Variations of Influenza Infections in a Subtropical City — Hong Kong date: 2015-01-28 words: 4625 flesch: 39 summary: Seasonal Influenza: Clinical Signs and Symptoms of Influenza Finding the real case-fatality rate of H5N1 avian influenza Seasonal influenza in the United States, France, and Australia: Transmission and prospects for control Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach Modeling and predicting seasonal influenza transmission in warm regions using climatological parameters Influenza virus transmission is dependent on relative humidity and temperature Influenza seasonality: Underlying causes and modeling theories Hospital admissions as a function of temperature, other weather phenomena and pollution levels in an urban setting in China Associations between mortality and meteorological and pollutant variables during the cool season in two Asian cities with sub-tropical climates: Hong Kong and Taipei Absolute humidity modulates influenza survival, transmission, and seasonality High temperature (30 ºC) blocks aerosol but not contact transmission of influenza virus Meteorological parameters as predictors for seasonal influenza Identification of the drivers will help to improve the understanding of influenza transmission and to alert officials to implement preemptive control measures for seasonal influenza. keywords: data; hong; humidity; influenza; kong; model; temperature; transmission; variations cache: cord-283537-49ic7p3u.txt plain text: cord-283537-49ic7p3u.txt item: #171 of 303 id: cord-284087-g2jfnxja author: Falcone, Valeria title: Influenza virus A(H1N1)pdm09 hemagglutinin polymorphism and associated disease in southern Germany during the 2010/11 influenza season date: 2013-02-09 words: 3424 flesch: 46 summary: Understanding the evolution of influenza virus is crucial to determine pathogenesis, vaccine efficacy, and resistance to antiviral drugs. Hemagglutinin (HA) and neuraminidase (NA) represent two major surface glycoproteins of influenza virus. keywords: human; influenza; mutation; pandemic; patients; t t; virus; viruses cache: cord-284087-g2jfnxja.txt plain text: cord-284087-g2jfnxja.txt item: #172 of 303 id: cord-285856-0sw3wt1i author: Naesens, Lieve title: Anti-influenza virus activity and structure–activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains date: 2009-02-05 words: 2976 flesch: 27 summary: Additional anti-influenza virus compounds should be urgently developed, having a novel antiviral target that is highly conserved amongst influenza virus (sub)types and, hence, less prone to genetic variation and resistance selection. The cellular entry process of influenza viruses has been unraveled since many years (reviewed in Skehel and Wiley, 2000) . keywords: activity; aglycoristocetin; anti; glycopeptide; influenza; squaric; virus cache: cord-285856-0sw3wt1i.txt plain text: cord-285856-0sw3wt1i.txt item: #173 of 303 id: cord-286368-kdwh4hgf author: Hui, David S.C. title: A clinical approach to the threat of emerging influenza viruses in the Asia‐Pacific region date: 2017-07-05 words: 7715 flesch: 34 summary: However, for some asymptomatic persons in which a substantial unprotected or prolonged exposure to an ill patient with A(H7N9) infection has occurred, initiation of empiric post-exposure antiviral treatment (e.g. oseltamivir 75 mg orally bd for 5 days), on the presumption that influenza virus infection has occurred, may be considered. influenza virus infection, including patients with severe immunosuppression, neonates and infants, pregnant and early post-partum women, elderly adults, persons with co-morbidities and other highly vulnerable patients; or, unprotected healthcare workers, especially those involved in AGP. keywords: a(h5n1; a(h7n9; avian; cases; days; human; infection; influenza; oseltamivir; patients; poultry; risk; treatment; viral; virus; viruses cache: cord-286368-kdwh4hgf.txt plain text: cord-286368-kdwh4hgf.txt item: #174 of 303 id: cord-287554-2lqy2ix9 author: Amarelle, Luciano title: Tratamiento antigripal: fármacos actualmente utilizados y nuevos agentes en desarrollo date: 2017-01-31 words: 5868 flesch: 31 summary: Un estudio clínico multicéntrico aleatorizado (ARBITR) mostró en pacientes con influenza tratados con arbidol, un acortamiento de la enfermedad con reducción de la severidad y de la emisión de virus 55 . La vacunación es fundamental en la prevención de la enfermedad y sus complicaciones, principalmente para grupos de riesgo como niños, ancianos, portadores de enfermedades respiratorias crónicas y embarazadas. keywords: actividad; antiviral; arn; cepas; como; con; célula; del; fusión; fármacos; han; huésped; influenza; inhibidores; las; los; ns1; oseltamivir; para; por; protein; proteína; que; son; tratamiento; una; viral; virales; virus; vitro cache: cord-287554-2lqy2ix9.txt plain text: cord-287554-2lqy2ix9.txt item: #175 of 303 id: cord-287824-zg5akivn author: Chan, Yinghan title: Advanced drug delivery systems can assist in managing influenza virus infection: A hypothesis date: 2020-09-24 words: 1159 flesch: -1 summary: Vaccine Anti-455 bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates 456 against resistant and non-resistant pathogens Perspectives and 459 advancements in the design of nanomaterials for targeted cancer theranostics Microparticles as Vaccine Adjuvants and Delivery Systems Investigation of 465 tunable acetalated dextran microparticle platform to optimize M2e-based influenza 466 vaccine efficacy Molecular assembly and application of biomimetic microcapsules Hybrid inorganic-organic capsules for eficient intracellular delivery of novel siRNAs 472 against influenza A (H1N1) virus infection Biodegradable Polyelectrolyte/Silica Composite Microcapsules as Carriers for Small 476 Application of dendrimers for the treatment of 479 infectious diseases Nanoparticle vaccines against infectious diseases Delivery Vehicles for Active Phytoconstituents Emerging Trends 492 in Nanomedicine for Topical Delivery in Skin Disorders: Current and Translational 493 Oligonucleotide 495 therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory 496 diseases Emerging trends in 498 the novel drug delivery approaches for the treatment of lung cancer Interactions 501 with the macrophages: An emerging targeted approach using novel drug delivery 502 systems in respiratory diseases Gene Delivery by PAMAM Dendrimer 505 Conjugated with the Nuclear Localization Signal Peptide Derived from Influenza B 506 Identification of biomarkers and genetic approaches toward chronic obstructive 510 pulmonary disease Inhibition of influenza A virus infection in vitro by saliphenylhalamide-loaded 513 porous silicon nanoparticles Enhanced inhibition of influenza virus infection 516 by peptide-noble-metal nanoparticle conjugates Development of an adjuvanted nanoparticle vaccine against influenza virus, an 520 in vitro study Pulmonary surfactant-biomimetic 523 nanoparticles potentiate heterosubtypic influenza immunity Protein Nanoparticle Immunization Induces Broad Cross-Protection against 527 Different Influenza Viruses in Mice Virus-mimetic polymer 530 nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine Porous gold nanoparticles for 533 attenuating infectivity of influenza A virus Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: 537 Another emerging application of nanomedicine Phase 3 Pivotal Trial of NanoFlu TM in Older Adults Editorial: Advances and challenges in nanomedicine Nanoethics: From utopian dreams and apocalyptic nightmares towards a 543 more balanced view The authors declare no conflict of interest, financial or otherwise. Single-371 dose mucosal immunization with a candidate universal influenza vaccine provides 372 rapid protection from virulent H5N1, H3N2 and H1N1 viruses Exploiting Nanotechnology to Target Viruses Universal influenza vaccines: from viruses to 378 nanoparticles Nanotherapeutic Anti-influenza Solutions: Current Knowledge and Future Challenges Influenza antivirals and resistance: The next 10 384 years? keywords: delivery; drug; influenza; vaccine; virus cache: cord-287824-zg5akivn.txt plain text: cord-287824-zg5akivn.txt item: #176 of 303 id: cord-288238-36hiiw91 author: Keshavarz, Mohsen title: Metabolic host response and therapeutic approaches to influenza infection date: 2020-03-05 words: 8165 flesch: 26 summary: Induction of protective immune response to intranasal administration of influenza virus-like particles in a mouse model Association of polymorphisms in inflammatory cytokines encoding genes with severe cases of influenza a/H1N1 and B in an Iranian population Acute encephalopathy associated with influenza and other viral infections Influenza vaccination for patients with chronic obstructive pulmonary disease: understanding immunogenicity, efficacy and effectiveness Effectiveness of influenza vaccines in asthma: a systematic review and meta-analysis The nutritional requirements for the propagation of poliomyelitis virus by the HeLa cell Energy metabolic disorder is a major risk factor in severe influenza virus infection: proposals for new therapeutic options based on animal model experiments Metabolic pathways of lung inflammation revealed by high-resolution metabolomics (HRM) of H1N1 influenza virus infection in mice Targeting metabolic reprogramming by influenza infection for therapeutic intervention Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species Influenza a virus PB1-F2 is involved in regulation of cellular redox state in alveolar epithelial cells Enhanced oxidative damage to DNA, lipids, and proteins and levels of some antioxidant enzymes, cytokines, and heat shock proteins in patients infected with influenza H1N1 virus Does influenza A infection increase oxidative damage Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children Lung histopathological findings in fatal pandemic influenza a (H1N1) Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS Oxidative stress in lungs of mice infected with influenza a virus Alterations in antioxidant defences in lung and liver of mice infected with influenza a virus Inhibition of reactive oxygen species production ameliorates inflammation induced by influenza a viruses via upregulation of SOCS1 and SOCS3 Inhibition of Nox2 oxidase activity ameliorates influenza a virus-induced lung inflammation Influenza a virus and TLR7 activation potentiate NOX2 oxidasedependent ROS production in macrophages Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy Dependence on O2-generation by xanthine oxidase of pathogenesis of influenza virus infection in mice Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD Alteration of copper-zinc superoxide dismutase 1 expression by influenza a virus is correlated with virus replication Inhibition of influenza infection by glutathione Influenza a virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2 Differential redox state contributes to sex disparities in the response to influenza virus infection in male and female mice Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus Glutathione-redox balance regulates c-rel-driven IL-12 production in macrophages: possible implications in Antituberculosis immunotherapy The cytokine storm of severe influenza and development of immunomodulatory therapy Inflammatory Monocytes Drive Influenza A Virus-Mediated Lung Injury in Juvenile Mice Role of indoleamine-2, 3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections Effects of interferons and viruses on metabolism Dynamics of the cellular metabolome during human cytomegalovirus infection Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy Early enhanced glucose uptake in human cytomegalovirus-infected cells Respiration and ATP level in BHK21/13S cells during the earlist stages of rubella virus replication Primary effects of the rubella virus on the metabolism of BHK-21 cells grown in suspension cultures Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus Respiration and glycolysis of human cells grown in tissue culture Some metabolic effects of poliomyelitis virus on tissue culture The aforementioned metabolic processes are not the only pathways affected by influenza virus infection. keywords: acid; activity; atp; cells; expression; fatty; glucose; glycolysis; increase; infection; influenza; metabolic; mice; pathways; production; replication; role; virus cache: cord-288238-36hiiw91.txt plain text: cord-288238-36hiiw91.txt item: #177 of 303 id: cord-288487-hs3wfffs author: Lambert, Stephen B title: The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children date: 2008-01-24 words: 5666 flesch: 39 summary: We calculated mean costs (total and by categories) with 95% confidence intervals (95% CI) and median costs with interquartile ranges for ARIs in study children. Influenza illnesses had a mean cost of $904, compared with RSV, $304, the next most expensive single-virus illness, although confidence intervals overlapped. keywords: aris; children; cost; data; illnesses; impact; influenza; mean; study; time; virus; viruses cache: cord-288487-hs3wfffs.txt plain text: cord-288487-hs3wfffs.txt item: #178 of 303 id: cord-288938-4bheqtk5 author: Hönemann, M. title: Influenza B virus infections in Western Saxony, Germany in three consecutive seasons between 2015 and 2018: Analysis of molecular and clinical features date: 2019-10-08 words: 3202 flesch: 49 summary: Last accessed 15.12 Update: Influenza Activity in the United States During the 2017-18 Season and Composition of the 2018-19 Influenza Vaccine Seasonal Influenza Reports The quadrivalent approach to influenza vaccination Evolutionary dynamic of antigenic residues on influenza B hemagglutinin Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination Three types of broadly reacting antibodies against Influenza B viruses induced by vaccination with seasonal influenza viruses Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarity Prediction of influenza B vaccine effectiveness from sequence data Intra-season Waning of Influenza vaccine effectiveness Simultaneous detection of influenza viruses A and B using real-time quantitative PCR WHO information for the molecular detection of influenza viruses Effect of a single mutation in neuraminidase on the properties of Influenza B virus isolates MEGA6: molecular evolutionary genetics analysis version 6.0 Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia, Spain Distribution of influenza virus types by age using case-based global surveillance data from twenty-nine countries Estimation of influenza-attributable medically attended acute respiratory illness by influenza type/subtype and age Influenza vaccine in heart failure: cumulative number of vaccinations, frequency, timing, and survival: A Danish Nationwide Cohort Study Estimating influenza disease burden from population-based surveillance data in the United States Age-and sexrelated risk factors for influenza-associated mortality in the United States between 1997-2007 Circulating pattern and genomic characteristics of influenza B viruses in Taiwan from 2003 to 2014 Human monoclonal antibodies broadly neutralizing against influenza B virus Cross-lineage protection by human antibodies binding the influenza B hemagglutinin Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results Influenza A/subtype and B/lineage effectiveness estimates for the 2011-2012 trivalent vaccine: cross-season and cross-lineage protection with unchanged vaccine From original antigenic sin to the universal influenza virus vaccine Immune history profoundly affects broadly protective B cell responses to influenza Age, influenza pandemics and disease dynamics This research was partially supported by the Association of Sponsors and Friends of Leipzig University (Vereinigung von Förderern und Freunden der Universität Leipzig). First isolated in 1940, influenza B virus diverged into two lineages, Victoria and Yamagata, in the late 1970s with similar clinical [2] but different phylodynamic properties [3] . keywords: influenza; lineage; patients; season; strains; vaccine; yamagata cache: cord-288938-4bheqtk5.txt plain text: cord-288938-4bheqtk5.txt item: #179 of 303 id: cord-289285-aof7xy13 author: Michaelis, Martin title: Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression date: 2011-05-17 words: 4332 flesch: 36 summary: Phospholipid biosynthesis from native and organometallic precursors Quantitative analysis of cellular proteome alterations in human influenza A virus-infected mammalian cell lines Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein Inflammatory responses in influenza A virus infection Role of apoptosis and cytokines in influenza virus morbidity Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans The A549 cell line, derived from a human pulmonary adenocarcinoma, is an established model for type II pneumocytes [36] , and commonly used for the investigation of the effect of influenza viruses on this cell type [see e.g. 6,37,38]. keywords: a549; cells; concentrations; expression; figure; glycyrrhizin; h5n1; infection; influenza; replication; virus cache: cord-289285-aof7xy13.txt plain text: cord-289285-aof7xy13.txt item: #180 of 303 id: cord-289439-jrvl0ykn author: Nelson, Martha I. title: Fogarty International Center collaborative networks in infectious disease modeling: Lessons learnt in research and capacity building date: 2018-10-23 words: 8729 flesch: 23 summary: The Multinational Influenza Seasonal Mortality Study (MISMS) has strengthened global capacity to study the epidemiology and evolutionary dynamics of influenza viruses in 80 countries by organizing international research activities and training workshops. The MISMS project was initiated in 2001 to build global research capacity for the study of influenza viruses using computational methods (http://misms.net, Box 1). keywords: data; disease; dynamics; ebola; et al; human; influenza; misms; modeling; models; new; pandemic; policy; programs; rapidd; research; studies; transmission; vaccination; virus; workshops cache: cord-289439-jrvl0ykn.txt plain text: cord-289439-jrvl0ykn.txt item: #181 of 303 id: cord-290004-v3ruj5bq author: Madsen, Anders title: Prospects and Challenges in the Development of Universal Influenza Vaccines date: 2020-07-06 words: 4407 flesch: 33 summary: The future of influenza vaccines: A historical and clinical perspective Development of a universal influenza vaccine A universal influenza vaccine: The strategic plan for the national institute of allergy and infectious diseases The Compelling Need for Game-Changing Influenza Vaccines an Analysis of the Influenza Vaccine Enterpris The role of Fc-FcγR interactions in IgG-mediated microbial neutralization Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection Highly conserved protective epitopes on influenza B viruses Natural T cell-mediated protection against seasonal and pandemic influenza. Vaccines Immunother Efforts to improve the seasonal influenza vaccine Safety, efficacy, and immunogenicity of Flublok in the prevention of seasonal influenza in adults Adjuvanted influenza vaccines. keywords: cell; development; influenza; protection; universal; vaccines; virus; viruses cache: cord-290004-v3ruj5bq.txt plain text: cord-290004-v3ruj5bq.txt item: #182 of 303 id: cord-290031-vffa1bu0 author: Richmond, Heather title: Seasonal influenza vaccination during a pandemic date: 2020-07-31 words: 1687 flesch: 30 summary: Several policies, such as vaccination strategies to accommodate physical distancing measures, change population recommendations, and timing and location of vaccination have been implemented to increase influenza vaccine uptake during the pandemic. Policy changes in Australia, together with strong communication from public health agencies and media reporting about the risk of coinfection and importance of influenza vaccination, generated significant demand for influenza vaccines early in the season. keywords: influenza; season; vaccination; vaccine cache: cord-290031-vffa1bu0.txt plain text: cord-290031-vffa1bu0.txt item: #183 of 303 id: cord-290100-wnjjqqn5 author: Wong, Samuel Y.S. title: Primary care physicians’ response to pandemic influenza in Hong Kong: a mixed quantitative and qualitative study date: 2012-07-11 words: 3952 flesch: 46 summary: 12 Acceptability of pandemic influenza vaccination was found to be higher in studies conducted in general practice in France and the Netherlands, at 60% and 80%, respectively. key: cord-290100-wnjjqqn5 authors: Wong, Samuel Y.S.; Kung, Kenny; Wong, Martin C.S.; Wong, Carmen; Tsui, Wendy; Chan, King; Liang, Jun; Lee, Nelson L.S.; Cheung, Annie W.L.; Wong, Eliza L.Y. title: Primary care physicians’ response to pandemic influenza in Hong Kong: a mixed quantitative and qualitative study date: 2012-07-11 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2012.03.015 sha: doc_id: 290100 cord_uid: wnjjqqn5 OBJECTIVES: keywords: care; doctors; h1n1; influenza; pandemic; public; vaccination cache: cord-290100-wnjjqqn5.txt plain text: cord-290100-wnjjqqn5.txt item: #184 of 303 id: cord-290352-0pc5eji4 author: de Jong, Menno D. title: Avian influenza A (H5N1) date: 2005-10-06 words: 9178 flesch: 31 summary: The structure and receptor binding properties of the 1918 influenza hemagglutinin Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR H5N1 influenza: a protean pandemic threat Molecular characterization of H9N2 influenza viruses: were they the donors of the internal genes of H5N1 viruses in Hong Kong? Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice Avian influenza-a challenge to global health care structures Replication of avian influenza A viruses in mammals Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia Molecular basis for the generation in pigs of influenza A viruses with pandemic potential Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics Avian influenza H5N1 in tigers and leopards Potential for transmission of avian influenza viruses to pigs Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus DNA vaccine encoding hemagglutinin provides protective immunity against H5N1 influenza virus infection in mice Transmission of H7N7 avian influenza While there has been no evidence of efficient transmission of influenza H5N1 virus between humans to date, caution and detailed investigations remain warranted in case of any cluster of infections, especially in view of the relatively rapid evolution H5N1 viruses have exhibited in recent years. keywords: avian; birds; et al; h5n1; hong; human; infections; influenza; influenza viruses; kong; outbreak; pandemic; poultry; strains; transmission; viruses cache: cord-290352-0pc5eji4.txt plain text: cord-290352-0pc5eji4.txt item: #185 of 303 id: cord-292528-8kdhf123 author: Lau, Yuk-Fai title: A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic date: 2009-02-25 words: 6915 flesch: 46 summary: There is an accumulating body of data showing that H5N1 virus vaccines are generally poorly immunogenic. The 2006-2007 South Hemisphere seasonal influenza vaccine, Fluvax, was from CSL Ptd Ltd. (Victoria, Australia). keywords: adjuvant; antibody; cells; dose; fig; group; h5n1; influenza; mice; pika; reduction; titer; vaccine; virus cache: cord-292528-8kdhf123.txt plain text: cord-292528-8kdhf123.txt item: #186 of 303 id: cord-292709-4hn55wui author: Nor, Mohd Basri Mat title: Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine date: 2017-12-31 words: 4561 flesch: 41 summary: Patients who meet clinical and epidemiological criteria should be tested for H5N1 avian influenza infection. Influenza viruses which are classified by their core proteins (i.e. A, B or C) and belong to the family orthomyxoviridae, cause predominantly respiratory disease in humans. keywords: avian; cases; disease; infection; influenza; patients; plague; pneumonia; syndrome; treatment; viruses cache: cord-292709-4hn55wui.txt plain text: cord-292709-4hn55wui.txt item: #187 of 303 id: cord-292794-okh6i4l1 author: Wang, Bin title: Protective efficacy of a broadly cross-reactive swine influenza DNA vaccine encoding M2e, cytotoxic T lymphocyte epitope and consensus H3 hemagglutinin date: 2012-06-27 words: 4791 flesch: 37 summary: A vaccine based on the extracellular domain of the M2 protein Matrix protein 2 vaccination and protection against influenza viruses, including subtype H5N1 Comparative efficacy of hemagglutinin, nucleoprotein, and matrix 2 protein gene-based vaccination against H5N1 influenza in mouse and ferret Vaxfectin-formulated influenza DNA vaccines encoding NP and M2 viral proteins protect mice against lethal viral challenge Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface Heterologous protection against influenza by injection of DNA encoding a viral protein A universal epitope-based influenza vaccine and its efficacy against H5N1 Crossprotection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvant In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses Pathogenesis and transmission of the novel swine-origin influenza virus A/H1N1 after experimental infection of pigs Experimental infection of pigs with the human 1918 pandemic influenza virus Experimental inoculation of pigs with pandemic H1N1 2009 virus and HI cross-reactivity with contemporary swine influenza virus antisera Novel reassortment of Eurasian Avian-like and pandemic/2009 influenza viruses in swine: infectious potential to humans Coadministration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice Coexpressed RIG-I Agonist Enhances Humoral Immune Response to Influenza Virus DNA Vaccine Complete protection against a H5N2 avian influenza virus by a DNA vaccine expressing a fusion protein of H1N1 HA and M2e Immunization of pigs against influenza virus infection by DNA vaccine priming followed by killed-virus vaccine boosting Importance of a prime-boost DNA/protein vaccination to protect chickens against low-pathogenic H7 avian influenza infection Vaccination of pigs with a DNA construct expressing an influenza virus M2-nucleoprotein fusion protein exacerbates disease after challenge with influenza A virus The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods A DNA transfection system for generation of influenza A virus from eight plasmids A simple method of estimating fifty per cent endpoints Sequence comparison between the extracellular domain of M2 protein human and avian influenza A viruses in pigs in southeastern China: potential for genetic reassortment? Genetic evolution of swine influenza A (H3N2) viruses in China from 1970 to Pathogenic and antigenic properties of phylogenetically distinct reassortant H3N2 swine influenza viruses cocirculating in the United States Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population Evaluation of hemagglutinin subtype 1 swine influenza viruses from the United States Evaluation of a protective immunity induced by an inactivated influenza H3N2 vaccine after an intratracheal challenge of pigs Antigenic and molecular heterogeneity in recent swine influenza A (H1N1) virus isolates with possible implications for vaccination policy Protection against a European H1N2 swine influenza virus in pigs previously infected with H1N1 and/or H3N2 subtypes Efficacy of inactivated swine influenza virus vaccines against the 2009 A/H1N1 influenza virus in pigs A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses A universal influenza keywords: consensus; dna; h1n1; influenza; m2e; mice; protection; swine; vaccines; virus; viruses cache: cord-292794-okh6i4l1.txt plain text: cord-292794-okh6i4l1.txt item: #188 of 303 id: cord-292856-7hjzzxtm author: Viasus, Diego title: Influenza A(H1N1)pdm09-related pneumonia and other complications date: 2012-10-31 words: 4223 flesch: 27 summary: 8, 24 One study 27 found that 70% of patients with influenza A(H1N1)pdm09 virus infection and invasive group A Streptococcus died, compared with an overall mortality rate of 2-6% for hospitalized influenza A(H1N1)pdm09 patients in other studies. Community-acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus Pulmonary imaging of pandemic influenza H1N1 infection: relationship between clinical presentation and disease burden on chest radiography and CT During the herald wave of the pandemic bacterial pneumonia relatively rare with fatal swine influenza (H1N1) pneumonia: if chest films have no focal segmental/lobar infiltrates, antibiotic therapy is unnecessary A 1-year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of COPD Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Children with asthma hospitalized with seasonal or pandemic influenza Clinical findings and demographic factors associated with intensive care unit admission in Utah due to 2009 novel influenza A (H1N1) infection Hospitalizations for pandemic (H1N1) 2009 among Maori and Pacific Islanders Surveillance of the first 205 confirmed hospitalised cases of pandemic H1N1 influenza in Ireland Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy Clinical presentation and prognosis of the 2009 H1N1 influenza A infection in HIV-1-infected patients: a Spanish multicenter study Early use of glucocorticoids was a risk factor for critical disease and death from pH1N1 infection Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis Risk factors for hospitalization and severe outcomes of 2009 pandemic H1N1 influenza in Quebec Timing of oseltamivir administration and outcomes in hospitalized adults with pandemic 2009 influenza A(H1N1) virus infection The role of pneumonia scores in the emergency room in patients infected by 2009 H1N1 infection Severity assessment tools in ICU patients with 2009 Influenza A (H1N1) pneumonia Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review Acute myocarditis mimicking acute myocardial infarction associated with pandemic 2009 (H1N1) influenza A virus Cardiac manifestations in patients with pandemic (H1N1) 2009 virus infection needing intensive care Electrocardiographic abnormalities in patients with novel H1N1 influenza virus infection Pediatric neurological complications of 2009 pandemic influenza A (H1N1) keywords: a(h1n1)pdm09; admission; bacterial; chronic; complications; disease; infection; influenza; pandemic; patients; pneumonia; virus cache: cord-292856-7hjzzxtm.txt plain text: cord-292856-7hjzzxtm.txt item: #189 of 303 id: cord-292963-8wzyfb2j author: Zeng, Zheng title: Imaging manifestations and pathological analysis of severe pneumonia caused by human infected avian influenza (H7N9)() date: 2015-03-02 words: 3327 flesch: 48 summary: The differential diagnosis of severe pneumonia caused by human infected avian influenza A (H7N9) Severe pneumonia caused by human infected avian influenza A (H7N9) should be distinguished from influenza A (H1N1 or H5N1) and severe acute respiratory syndromes, and other conditions. According to the diagnostic and treatment protocol for human infected avian influenza A (H7N9) established by National Council on Health and Family Planning Commission, P. R. China (edition, 2014), the cases with any one of the following criteria can be diagnosed as severe. keywords: avian; cases; h7n9; influenza; lesions; pneumonia cache: cord-292963-8wzyfb2j.txt plain text: cord-292963-8wzyfb2j.txt item: #190 of 303 id: cord-293234-ouykx6g5 author: Puig-Barberà, J. title: Effectiveness of the 2010–2011 seasonal influenza vaccine in preventing confirmed influenza hospitalizations in adults: A case–case comparison, case-control study date: 2012-08-24 words: 4424 flesch: 38 summary: As a consequence of antigenic drift, influenza vaccines are to be a produced every year [3] . Information related to the administration of the 2009-2010 seasonal influenza vaccine, the A(H1N1) pandemic vaccine and previous 23-valent polysaccharide plain pneumococcal vaccinations was obtained from the Vaccine Information System. keywords: age; case; conditions; controls; effectiveness; influenza; pcr; risk; study; vaccine; years cache: cord-293234-ouykx6g5.txt plain text: cord-293234-ouykx6g5.txt item: #191 of 303 id: cord-293299-gdew0ueo author: Jordan, William S. title: Influenza Research in the Soviet Union—1974 date: 1974-12-17 words: 5188 flesch: 43 summary: A long historical tradition for the use of livevirus vaccines in the Soviet Union dates from Smorodintsev's experimental infection of volunteers with influenza virus in 1937 There is little interest in the use of inactivated vaccine by parenteral administration, although such vaccine is now being produced experimentally and is to be utilized, if approved, in hyperimmunization of volunteers for the production of immunoglobulin against influenza virus. Administration and control. keywords: data; influenza; institute; model; morbidity; research; soviet; union; virus; volunteers cache: cord-293299-gdew0ueo.txt plain text: cord-293299-gdew0ueo.txt item: #192 of 303 id: cord-293472-d3iwlpsr author: Afilalo, Marc title: Evaluation and Management of Seasonal Influenza in the Emergency Department date: 2012-04-06 words: 9922 flesch: 31 summary: The epidemiology of influenza 1948-1953 Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial Oral oseltamivir treatment of influenza in children Viral shedding in children with influenza virus infections treated with neuraminidase inhibitors Duration of influenza A virus shedding in hospitalized patients and implications for infection control Viral loads and duration of viral shedding in adult patients hospitalized with influenza Prolonged shedding of amantadineresistant influenzae A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis Common emergence of amantadineand rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults Prolonged excretion of amantadine-resistant influenza A virus quasi species after cessation of antiviral therapy in an immunocompromised patient Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy Prolonged shedding of multidrugresistant influenza A virus in an immunocompromised patient The effects of influenza virus infection on FEV1 in asthmatic children. Public Health Agency of Canada APPENDIX 1: REFERENCES FOR TABLE 4 Manufacturer's product information or product insert Comparison of Binax NOW and Directigen for rapid detection of influenza A and B Evaluation of three immunoassay kits for rapid detection of influenza A and B Comparison of rapid diagnostic techniques for respiratory syncytial virus and influenza A virus respiratory infections in young children Comparison of a new neuraminidase detection assay with an enzyme immunoassay, immunofluorescence, and culture for rapid detection of influenza A and B viruses in nasal wash specimens Application of Directigen FLU-A for the detection of influenza A virus in human and nonhuman specimens Comparison of Directigen FLU-A with viral isolation and direct immunofluorescence for the rapid detection and identification of influenza A virus Comparison of rapid detection methods for influenza A and their value in health care management of institutionalized geriatric patients Evaluation of a rapid enzyme immunoassay for detection of influenza A virus Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus Evaluation of the Directigen FluA1B test for rapid diagnosis of influenza virus type A and B infections Clinical evaluation of the ZstatFlu-II test: a chemiluminescence rapid diagnostic test for influenza virus Comparison of the Directigen Flu A1B test, the QuickVue Influenza test, and clinical case definition to viral culture and reverse transcription-PCR for rapid diagnosis of influenza virus infection Comparison of lateral-flow immunoassay and enzyme immunoassay with viral culture for rapid detection of influenza virus in nasal wash specimens from children Comparison of the Denka Seiken INFLU A-B Quick and BD Directigen Flu A1B kits with fluorescent-antibody staining and shell vial culture methods for rapid detection of influenza viruses Suboptimal detection of influenza virus in adults by the Directigen Flu A1B enzyme immunoassay and correlation of results with the number of antigen-positive cells detected by cytospin immunofluorescence Comparison of four clinical specimen types for detection of influenza A and B viruses by optical immunoassay (FLU OIA test) and cell culture methods Evaluation of a rapid optical immunoassay for influenza viruses (FLU OIA test) in comparison with cell culture and reverse transcription-PCR Evaluation of Biostar FLU OIA assay for rapid detection of influenza A and B viruses in respiratory specimens Evaluation of an optical immunoassay for the rapid detection of influenza A and B viral antigens A flu optical immunoassay (ThermoBioStar's FLU OIA): a diagnostic tool for improved influenza management Simultaneous detection and typing of influenza viruses A and B by a nested reverse transcription-PCR: comparison to virus isolation and antigen detection by immunofluorescence and optical immunoassay (FLU OIA) Evaluation of diagnostic tests for influenza in a pediatric practice Evaluation of a rapid test (QuickVue) compared with the shell vial assay for detection of influenza virus clearance after antiviral treatment Influenza virological surveillance in children: the use of the QuickVue rapid diagnostic test QuickVue influenza test for rapid detection of influenza A and B viruses in a pediatric population Clinical evaluation of an immunochromatography test for rapid diagnosis of influenza Evaluation of immunochromatography method for rapid detection of influenza A and B viruses Evaluation of new rapid influenza virus detection kit-QUICK S-INFLU A/B SEIKEN Comparison of a new lateral-flow chromatographic membrane immunoassay to viral culture for rapid detection and differentiation of influenza A and B viruses in respiratory specimens Evaluation of a neuraminidase detection assay for the rapid detection of influenza A and B virus in children New point of care test is highly specific but less sensitive for influenza A and B in children and adults Evaluation of an immunochromatography test using enzyme immunoassay for rapid detection influenza A and B viruses Comparison of three rapid diagnostic kits using immunochromatography for detection of influenza A viruses Evaluation of an immunochromatography test kit for rapid diagnosis of influenza Evaluation of flow-through immunoassay for rapid detection of influenza A and B viruses keywords: care; children; detection; health; hours; illness; infection; influenza; influenza virus; onset; patients; persons; symptoms; test; treatment; virus; viruses cache: cord-293472-d3iwlpsr.txt plain text: cord-293472-d3iwlpsr.txt item: #193 of 303 id: cord-294323-mryiqmsw author: Kumar, Binod title: The emerging influenza virus threat: status and new prospects for its therapy and control date: 2018-01-10 words: 8210 flesch: 37 summary: A viruses A distinct lineage of influenza A virus from bats The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses Influenza: the once and future pandemic The origin of the 1918 pandemic influenza virus: a continuing enigma Influenza: the mother of all pandemics Updating the accounts: global mortality of the 1918-1920 Spanish influenza pandemic Characterization of the 1918 influenza virus polymerase genes Is the gene pool of influenza viruses in shorebirds and gulls different from that in wild ducks? Dating the emergence of pandemic influenza viruses Detection and isolation of 2009 pandemic influenza A/H1N1 virus in commercial piggery Role of neuraminidase in lethal synergism between influenza virus and Streptococcus pneumoniae Emerging infections: pandemic influenza Summary report on the Asian influenza epidemic in Japan Public health and medical responses to the 1957-58 influenza pandemic Observations on excess mortality associated with epidemic influenza Understanding original antigenic sin in influenza with a dynamical system Independent variation in nature of hemagglutinin and neuraminidase antigens of influenza virus: distinctiveness of hemagglutinin antigen of Hong Kong-68 virus Origin and progress of the 1968-69 Hong Kong influenza epidemic On the origin of the human influenza virus subtypes H2N2 and H3N2 Influenza pandemics of 1918 and 2009: a comparative account Pandemic swine influenza virus (H1N1): a threatening evolution The persistent legacy of the 1918 influenza virus Pandemic influenza A H1N1 (2009) virus: lessons from the past and implications for the future Pandemic (H1N1) 2009 influenza Pandemic influenza A (H1N1) deaths among children-United States Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California Global mortality estimates for the 2009 Influenza Pandemic from the GLaMOR project: a modeling study Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds Tissue tropism and pathology of natural influenza virus infection in black-headed gulls (Chroicocephalus ridibundus) Avian Influenza A(H10N7) virus-associated mass deaths among harbor seals Characterization of two influenza A viruses from a pilot whale Influenza virus reservoirs and intermediate hosts: dogs, horses, and new possibilities for influenza virus exposure of humans Equine influenza A(H3N8) virus isolated from Bactrian camel One health, multiple challenges: The inter-species transmission of influenza A virus Preliminary epidemiology of human infections with highly pathogenic avian influenza A(H7N9) virus Human infection with highly pathogenic avian influenza A(H7N9) virus Novel reassortant avian influenza A(H5N6) viruses in humans Highly pathogenic avian influenza virus (H5N8) in domestic poultry and its relationship with migratory birds in South Korea during Avian influenza viruses in mammals Survival of influenza viruses on environmental surfaces Prevalence of gastrointestinal symptoms in patients with influenza, clinical significance, and pathophysiology of human influenza viruses in faecal samples: what do we know Onset and duration of symptoms and timing of disease transmission of 2009 influenza A (H1N1) in an outbreak in Fukuoka Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and the seasonal influenza Influenza viruses belong to the family Orthomyxoviridae and are the leading cause of severe respiratory illness across the world. keywords: avian; drugs; h1n1; h3n2; human; infections; influenza; neuraminidase; novel; pandemic; resistance; strains; vaccines; virus; viruses cache: cord-294323-mryiqmsw.txt plain text: cord-294323-mryiqmsw.txt item: #194 of 303 id: cord-295531-zojb3cew author: Huggett, Kathryn D. title: Influenza A date: 2008-01-10 words: 2096 flesch: 45 summary: Detailed information on influenza viruses can be located at: http://www3.accessmedicine. com/content.aspx?aID=74879&searchStr=influenza+a+virus#74879 Overview of the WHO Global Influenza Programme Haemagglutination-inhibiting antibody to influenza virus Antiviral therapy for influenza: a clinical and economic comparative review Population-wide benefits of routine vaccination of children against influenza Strategies for use of a limited influenza vaccine supply Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice Antigenic drift and variability of influenza viruses In vitro and in vivo assay systems for study of influenza virus inhibitors The terminology for influenza viruses is directly related to the type of virus, the origin or place it was first located, and the year of its discovery. keywords: day; influenza; treatment; virus; viruses cache: cord-295531-zojb3cew.txt plain text: cord-295531-zojb3cew.txt item: #195 of 303 id: cord-296277-paqu1t1e author: Fragaszy, Ellen B title: Cohort Profile: The Flu Watch Study date: 2016-03-03 words: 3221 flesch: 40 summary: A major strength is the inclusion of different household types (rather than just households with children, as in earlier studies) which allows influenza infections to be explored across the whole of society. Ideally, cohorts would have had pre-and post-influenza season bleeds, but recruitment periods were not perfectly streamlined with influenza seasons so adjustments for bleed timings were made during analysis. keywords: cell; cohort; data; illness; infection; influenza; pandemic; participants; season; study cache: cord-296277-paqu1t1e.txt plain text: cord-296277-paqu1t1e.txt item: #196 of 303 id: cord-296469-h0ma163u author: Gellin, Bruce G. title: Preparing for the unpredictable: The continuing need for pandemic influenza preparedness date: 2016-10-26 words: 1502 flesch: 39 summary: While this event is advertised as a programme review, in reality as an examination of the progress achieved during the decade, it should also serve to direct the global community on the path forward for the work that remains to achieve global pandemic influenza vaccine and vaccination preparedness. [14] , and WHO's restructuring of its approach to global health emergencies The Global Action Plan for Influenza Vaccines was structured around three broad objectives that underpin pandemic influenza vaccine and vaccination preparedness: -evidence-based increase in seasonal influenza vaccine use; -increase in influenza vaccine production capacity and regulatory capacity; -research and development for improved influenza vaccines. keywords: global; influenza; pandemic; vaccine cache: cord-296469-h0ma163u.txt plain text: cord-296469-h0ma163u.txt item: #197 of 303 id: cord-296935-y77c4ro4 author: Couch, Robert B. title: Prior Infections With Seasonal Influenza A/H1N1 Virus Reduced the Illness Severity and Epidemic Intensity of Pandemic H1N1 Influenza in Healthy Adults date: 2011-11-10 words: 3998 flesch: 43 summary: Comparison of influenza and rhinovirus illnesses indicated that presentation with fever and prominent myalgias increased the likelihood that influenza virus infection induced the illness, while prominence of rhinorrhea increased the likelihood of a rhinovirus infection. A virus induce crossprotective immunity against A(H1N1) pandemic influenza virus in a ferret model Protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in Hong Kong The epidemiology of influenza Epidemiological and clinical aspects of influenza Epidemiology of the Hong Kong/68 variant of influenza A2 in Britain Morbidity and mortality characteristics of Asian strain influenza Hong Kong influenza: the epidemiologic features of a high school family study analyzed and compared with a similar study during the 1957 Asian influenza epidemic Outbreak of influenza A/USSR/77 at Marquette University Communitywide surveillance of influenza after outbreaks due to H3N2 (A/Victoria/75 and A/Texas/77) and H1N1 (A/USSR/77) influenza viruses Session V. Summary of clinical studies. keywords: antibody; h1n1; illness; infections; influenza; study; virus; viruses cache: cord-296935-y77c4ro4.txt plain text: cord-296935-y77c4ro4.txt item: #198 of 303 id: cord-296998-ep46lzeo author: Pawelec, Graham title: Recent advances in influenza vaccines date: 2020-04-28 words: 3691 flesch: 34 summary: Efforts to improve the effectiveness of influenza vaccines include developing universal vaccines independent of the circulating strains in any particular season and stimulating cellular as well as humoral responses, especially in the elderly. And, unlike the SARS-1 epidemic and, we hope, the SARS-CoV-2 pandemic, influenza will not be eliminated and thus efforts to improve influenza vaccines will remain of crucial importance. keywords: cells; infection; influenza; responses; strains; text; vaccination; vaccines cache: cord-296998-ep46lzeo.txt plain text: cord-296998-ep46lzeo.txt item: #199 of 303 id: cord-297022-zs5m36cp author: Kwong, Jeffrey C. title: Appropriate measures of influenza immunization program effectiveness date: 2007-01-22 words: 912 flesch: 37 summary: A better measure of viral activity is the proportion of influenza tests positive (the number of cases of lab-confirmed influenza divided by the number of tests performed). That only 2 cases of influenza per 10,000 people are identified during months of influenza activity, when the actual rates of disease approach 5 per 100 people, further raises concern that any laboratory-derived measures of influenza activity are vulnerable to ascertainment and sampling biases. keywords: influenza; tests cache: cord-297022-zs5m36cp.txt plain text: cord-297022-zs5m36cp.txt item: #200 of 303 id: cord-297742-0pfrk5uk author: Simusika, Paul title: An evaluation of the Zambia influenza sentinel surveillance system, 2011–2017 date: 2020-01-13 words: 5506 flesch: 39 summary: The World Health Organization (WHO) recommends that established influenza surveillance systems undergo a comprehensive evaluation periodically, beginning 1-2 years after implementation in order to ascertain how well the system fulfills its purposes key: cord-297742-0pfrk5uk authors: Simusika, Paul; Tempia, Stefano; Chentulo, Edward; Polansky, Lauren; Mazaba, Mazyanga Lucy; Ndumba, Idah; Mbewe, Quinn K.; Monze, Mwaka title: An evaluation of the Zambia influenza sentinel surveillance system, 2011–2017 date: 2020-01-13 journal: BMC Health Serv Res DOI: 10.1186/s12913-019-4884-5 sha: doc_id: 297742 cord_uid: 0pfrk5uk BACKGROUND: Over the past decade, influenza surveillance has been established in several African countries including Zambia. keywords: data; evaluation; illness; indicators; influenza; performance; score; surveillance; system; zambia cache: cord-297742-0pfrk5uk.txt plain text: cord-297742-0pfrk5uk.txt item: #201 of 303 id: cord-297829-aynigoud author: Zhang, Li title: Post-pandemic assessment of public knowledge, behavior, and skill on influenza prevention among the general population of Beijing, China date: 2014-04-13 words: 3323 flesch: 47 summary: There were significant differences in health literacy level related to influenza among the different gender, age, educational level, occupational status, and location groups (p < 0.05). There were significant differences in health literacy level related to influenza among the different gender, age, educational level, occupational status, and location groups (p < 0.05). keywords: beijing; health; influenza; knowledge; skill cache: cord-297829-aynigoud.txt plain text: cord-297829-aynigoud.txt item: #202 of 303 id: cord-298216-iq7fenxm author: Jiang, Chao title: Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season date: 2020-05-13 words: 1620 flesch: 14 summary: The epidemiology of severe 495 acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients Clinical 498 features and short-term outcomes of 144 patients with SARS in the greater Toronto area Clinical progression and viral 501 load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study A comparison of the clinical and 538 epidemiological characteristics of adult patients with laboratory-confirmed influenza A or B 539 during the 2011-2012 influenza season in Korea: a multi-center study Comparison of 541 clinical features and outcomes of medically attended influenza A and influenza B in a defined 542 population over four seasons Seasonal 545 influenza A/H3N2 virus infection and IL-1Beta, IL-10, IL-17, and IL-28 polymorphisms in 546 Iranian population Differences in clinical features between influenza A H1N1, A 548 H3N2, and B in adult patients Prediction of H7N9 epidemic in China Proinflammatory effects of the hemagglutinin protein of the 552 avian influenza A (H7N9) virus and microRNAmediated homeostasis response in THP1 cells Lung pathology of fatal severe 565 acute respiratory syndrome Lung pathology of severe 567 acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore Multiple organ infection and the 570 pathogenesis of SARS Molecular pathology analyses of two fatal 572 human infections of avian influenza A(H7N9) virus Emerging H7N9 influenza A (novel reassortant avian-origin) 574 pneumonia: radiologic findings Pathology and virology findings in 576 cases of fatal influenza A H1N1 virus infection in 2009-2010 Lung pathology in 578 fatal novel human influenza A (H1N1) infection Clinical features of pneumonia caused by 2009 580 influenza A(H1N1) virus in Beijing Pathological study of 582 archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam molecular biology, and pathogenesis of avian influenza A (H5N1) 585 infection in humans Apoptosis and pathogenesis of avian influenza A (H5N1) virus in humans Re-emergence of fatal epidemiological features of coronavirus HKU1-associated community-acquired pneumonia An outbreak of coronavirus OC43 595 respiratory infection in Normandy, France Coronavirus 229E-related 597 pneumonia in immunocompromised patients Detection of human coronavirus NL63 in 599 young children with bronchiolitis Comparison of the pathology caused by H1N1, H5N1, and 601 H3N2 influenza viruses Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options 605 and Potential Targets for Novel Therapies Hopes rise for coronavirus drug remdesivir Remdesivir for severe acute respiratory syndrome coronavirus 2 608 causing COVID-19: in adult 683 subjects with well-controlled asthma Evolution of pandemic influenza virus A(H1N1)pdm09 in 2009-2016: dynamics of receptor 686 specificity of the first hemagglutinin subunit (HA1) Homology modeling study toward identifying 688 structural properties in the HA2 B-loop that would influence the HA1 receptor-binding site Subunit Vaccines Against Emerging Pathogenic Human The SARS-CoV-2 Vaccine Pipeline: an Overview Progress and Prospects on Vaccine Development 705 against SARS-CoV-2. keywords: clinical; coronavirus; influenza; sars; syndrome; virus cache: cord-298216-iq7fenxm.txt plain text: cord-298216-iq7fenxm.txt item: #203 of 303 id: cord-298551-ua90xoak author: Bennet, Rutger title: Influenza epidemiology among hospitalized children in Stockholm, Sweden 1998–2014 date: 2016-06-14 words: 3113 flesch: 45 summary: key: cord-298551-ua90xoak authors: Bennet, Rutger; Hamrin, Johan; Wirgart, Benita Zweygberg; Östlund, Maria Rotzén; Örtqvist, Åke; Eriksson, Margareta title: Influenza epidemiology among hospitalized children in Stockholm, Sweden 1998–2014 date: 2016-06-14 journal: Vaccine DOI: 10.1016/j.vaccine.2016.04.082 sha: doc_id: 298551 cord_uid: ua90xoak BACKGROUND: Retrospective study of annually collected data of virologically confirmed influenza in hospitalized children 0–17 years living in the catchment area (230,000 children). keywords: children; factors; influenza; pandemic; risk; study cache: cord-298551-ua90xoak.txt plain text: cord-298551-ua90xoak.txt item: #204 of 303 id: cord-298776-tjw45t3f author: Al Awaidi, Salah title: Influenza vaccination situation in Middle-East and North Africa countries: Report of the 7th MENA Influenza Stakeholders Network (MENA-ISN) date: 2018-08-17 words: 3133 flesch: 37 summary: Each country representative summarized their current situation of influenza surveillance, influenza vaccination coverage and actions achieved, and provided a list of country objectives for the upcoming 3 years. Participating countries concluded that despite an increase in vaccine uptake observed during the last few years, influenza vaccination coverage remains relatively low. keywords: countries; country; coverage; influenza; mena; surveillance; vaccination; vaccine cache: cord-298776-tjw45t3f.txt plain text: cord-298776-tjw45t3f.txt item: #205 of 303 id: cord-299207-lw0cv74b author: Upadhyay, Ranjit Kumar title: Modeling the spread of bird flu and predicting outbreak diversity date: 2007-05-08 words: 4390 flesch: 51 summary: A simple model for complex dynamical transitions in epidemics Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late Applications of mathematical models to the epidemiology of influenza: a critique Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China Avian influenza-a challenge to global health care structures The Transmission of Epidemic Influenza Fitting the bill Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia Study on transmission model of avian influenza A contribution to the mathematical theory of epidemics Avian H5N1 influenza in cats The impact of a monthly rest day on avian influenza virus isolation rates in retail live poultry markets in Hong Kong Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia Highly pathogenic H5N1 influenza virus infection in migratory birds The influenza virus gene pool in a poultry market in South Central China Containing pandemic influenza at the source Recent influenza A (H1N1) infections of pigs and turkeys in northern Europe Characterization of H5N1 influenza A viruses isolated during the 2003-2004 influenza outbreaks in Japan Transmissibility of 1918 pandemic influenza Re-emergence of fatal human influenza A subtype H5N1 disease SARS: How a Global Epidemic Was Stopped, WHO Protective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8+ T cells expressing gamma interferon Cross-reactive, cell-mediated immunity and protection of chickens from lethal H5N1 influenza virus infection in Hong Kong poultry markets Pandemic influenza: a zoonosis? Characterization of avian H5N1 influenza viruses from poultry in Hong Kong Avian influenza in Hong Kong Family clustering of avian influenza Independence of evolutionary and mutational rates after transmission of avian influenza viruses to swine Re-emerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia? Domesticated birds may become infected with avian influenza viruses through direct contact with infected waterfowl or other infected poultry keywords: avian; bird; epidemic; influenza; model; poultry; transmission; virus cache: cord-299207-lw0cv74b.txt plain text: cord-299207-lw0cv74b.txt item: #206 of 303 id: cord-299359-s8j78naz author: Sundaram, Maria E. title: Influenza Vaccination Is Not Associated With Detection of Noninfluenza Respiratory Viruses in Seasonal Studies of Influenza Vaccine Effectiveness date: 2013-09-15 words: 3249 flesch: 32 summary: Estimating vaccine effectiveness against laboratory-confirmed influenza using a sentinel physician network: results from the 2005-2006 season of dual A and B vaccine mismatch in Canada Effectiveness of inactivated influenza vaccines varied substantially with antigenic match from the 2004-2005 season to the 2006-2007 season Influenza vaccine effectiveness in Wisconsin during the 2007-08 season: comparison of interim and final results Moderate influenza vaccine effectiveness in I-MOVE: a European network to measure the effectiveness of influenza vaccines Early estimates of seasonal influenza vaccine effectiveness in Europe among target groups for vaccination: results from the I-MOVE multicentre case-control study Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine Virus interference and estimates of influenza vaccine effectiveness from test-negative studies The test-negative design for estimating influenza vaccine effectiveness Mortality due to influenza in the United States-an annualized regression approach using multiple-cause mortality data The burden of influenza in children Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). The results of this analysis strongly support the validity of case vs test-negative control study designs that are currently used in multiple countries to estimate influenza vaccine effectiveness in the outpatient setting. keywords: children; control; effectiveness; influenza; vaccination; vaccine; virus cache: cord-299359-s8j78naz.txt plain text: cord-299359-s8j78naz.txt item: #207 of 303 id: cord-299364-t549rf3o author: Noh, Ji Yun title: Clinical performance of the Sofia™ Influenza A+B FIA in adult patients with influenza-like illness date: 2015-10-31 words: 1653 flesch: 44 summary: Diagnostic Microbiology and Infectious Disease DOI: 10.1016/j.diagmicrobio.2015.05.016 sha: doc_id: 299364 cord_uid: t549rf3o Abstract The Sofia™ Influenza A+B FIA demonstrated 74.0% sensitivity and 95.4% specificity for influenza A in patients with influenza-like illness in 2012–2013 season. The Sofia™ Influenza A + B FIA (Quidel Corporation, CA, USA) is a novel fluorescent immunoassay used to detect influenza A and B within 15 minutes using the Sofia Analyzer (Lewandrowski et al., 2013) . keywords: influenza; sofia cache: cord-299364-t549rf3o.txt plain text: cord-299364-t549rf3o.txt item: #208 of 303 id: cord-299613-5ju5fcf4 author: Arthi, Vellore title: Disease, downturns, and wellbeing: Economic history and the long-run impacts of COVID-19 date: 2020-11-03 words: 17514 flesch: 39 summary: Although urban centers were associated with higher pandemic mortality, the opposite population gradient prevailed when comparing among cities, or among rural areas: in both cases, smaller, less dense localities fared worse (Acuna-Soto et al., 2011; Chowell et al., 2008) , suggestive perhaps of capacity constraints in the healthcare workforce and medical infrastructure. Likewise, foreign-born status not only predicted higher pandemic mortality in Hartford, Connecticut, but the relationship between nativity and mortality persisted even after controlling for socioeconomic status, population density, and neighborhood ethnic composition, indicating perhaps a role for social factors, or language or cultural barriers to the adoption of relevant public health measures (Tuckel et al., 2006) . keywords: 1918; covid-19; crisis; data; disease; effects; et al; evidence; exposure; health; history; human; income; individuals; influenza; influenza pandemic; instance; labor; market; mortality; pandemic; past; population; rates; run; u.s cache: cord-299613-5ju5fcf4.txt plain text: cord-299613-5ju5fcf4.txt item: #209 of 303 id: cord-300311-eah49b3g author: Bueving, Herman J. title: What is the role of virus vaccination in patients with asthma? date: 2007-05-30 words: 2985 flesch: 41 summary: A randomized double-blind placebo-controlled trial Influenza vaccination in children with asthma: randomized double-blind placebo-controlled trial Until now, the only RCT investigating the clinical effectiveness of influenza vaccination in children Burden of influenza in children in the community Invited Commentary: Use of selective viral cultures to adjust nonvirologic endpoints in studies of influenza vaccine efficacy Incidence of influenza and associated illness in children aged 0-19 years: a systematic review Vaccines for preventing influenza in healthy adults Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review Methodological quality of studies and patient age as major sources of variation in efficacy estimates of influenza vaccination in healthy adults: a meta-analysis Clinical effectiveness of conventional influenza vaccination in asthmatic children Effectiveness of influenza vaccine for the prevention of asthma exacerbations Influenza vaccination in patients with asthma: effect on the frequency of upper respiratory tract infections and exacerbations Vaccines for preventing influenza in people with asthma. The spectrum of viruses found consists of rhinovirus, coronavirus, respiratory syncytial virus (RSV), influenza virus, and an assortment of other viruses. keywords: asthma; children; exacerbations; influenza; patients; vaccination cache: cord-300311-eah49b3g.txt plain text: cord-300311-eah49b3g.txt item: #210 of 303 id: cord-300900-0wfsr4iw author: Yotsapon, Thewjitcharoen title: Trends in influenza and pneumococcal vaccine coverage in Thai patients with type 2 diabetes mellitus 2010-2018: Experience from a tertiary diabetes center in Bangkok date: 2020-05-11 words: 3960 flesch: 37 summary: Our main findings from this study were that the trends of influenza vaccination rates increased over the 9-year study period but remained suboptimal as half of T2DM patients did not receive influenza vaccination. The trends of influenza vaccination rates increased from 32.9% in 2010 to 52.2% in 2018 but the trends of pneumococcal vaccination rates were relatively stable at less than 20%. keywords: diabetes; influenza; patients; pneumococcal; rate; vaccination; vaccine cache: cord-300900-0wfsr4iw.txt plain text: cord-300900-0wfsr4iw.txt item: #211 of 303 id: cord-302141-gd663uag author: Vousden, Nicola title: Lessons learned from the A (H1N1) Influenza Pandemic date: 2020-10-12 words: 5435 flesch: 35 summary: One study in Mali estimated that maternal influenza immunisation could be highly cost-effective in low-income countries if programmatic costs are kept low, for example through delivery in combination with existing vaccine programmes (54) . The aim of this review is to describe the current evidence around the epidemiology and impact of seasonal and H1N1 influenza in pregnancy, the effectiveness and use of influenza immunisation with the aim of identifying learning points from past pandemic relevant to the current COVID-19 pandemic. keywords: immunisation; influenza; pandemic; pregnancy; review; risk; women cache: cord-302141-gd663uag.txt plain text: cord-302141-gd663uag.txt item: #212 of 303 id: cord-302529-43pd2qsp author: El Moussi, Awatef title: Virological Surveillance of Influenza Viruses during the 2008–09, 2009–10 and 2010–11 Seasons in Tunisia date: 2013-09-19 words: 3251 flesch: 39 summary: key: cord-302529-43pd2qsp authors: El Moussi, Awatef; Pozo, Francisco; Ben Hadj Kacem, Mohamed Ali; Ledesma, Juan; Cuevas, Maria Teresa; Casas, Inmaculada; Slim, Amine title: Virological Surveillance of Influenza Viruses during the 2008–09, 2009–10 and 2010–11 Seasons in Tunisia date: 2013-09-19 journal: PLoS One DOI: 10.1371/journal.pone.0074064 sha: doc_id: 302529 cord_uid: 43pd2qsp BACKGROUND: The data contribute to a better understanding of the circulation of influenza viruses especially in North-Africa. We describe in this report the findings of laboratory-based surveillance of human cases of influenza virus and other respiratory viruses' infection during three seasons in Tunisia. keywords: a(h1n1)pdm09; cases; influenza; pandemic; season; surveillance; tunisia; viruses cache: cord-302529-43pd2qsp.txt plain text: cord-302529-43pd2qsp.txt item: #213 of 303 id: cord-302713-h3aoag4y author: Jauréguiberry, Stéphane title: Clinical and Microbiological Evaluation of Travel‐Associated Respiratory Tract Infections in Travelers Returning From Countries Affected by Pandemic A(H1N1) 2009 Influenza date: 2011-12-08 words: 3014 flesch: 45 summary: The main etiological agents were influenza A(H1N1) 2009 (18%), influenza viruses (14%), and rhinovirus (20%). 3 Seroconversion for influenza virus was confirmed in 12% of 211 febrile Swiss travelers compared with 2.8% for all Swiss travelers surveyed; the incidence was estimated to be around one influenza-associated event per 100 person-months abroad. keywords: a(h1n1; influenza; patients; rti; travelers; virus; viruses cache: cord-302713-h3aoag4y.txt plain text: cord-302713-h3aoag4y.txt item: #214 of 303 id: cord-304023-s22wi0t0 author: Basile, L. title: Seasonal influenza surveillance: Observational study on the 2017–2018 season with predominant B influenza virus circulation date: 2019-10-30 words: 2804 flesch: 43 summary: A panel of respiratory viruses is investigated: Influenza virus A (IVA), influenza B (IVB) and C virus (IVC), and other respiratory viruses: Respiratory syncytial (RSV), parainfluenza 1, 2, 3 and 4 (PIV) viruses, adenovirus (ADV), coronavirus (CoV), enterovirus (EV), human rhinovirus (HRV), human metapneumovirus (HMPV) and human bocavirus (HBoV). 1, 2 Of the four types of seasonal influenza viruses (IV) (A, B, C and D), A and B viruses cause seasonal epidemics of disease. keywords: age; cases; influenza; season; vaccine; virus cache: cord-304023-s22wi0t0.txt plain text: cord-304023-s22wi0t0.txt item: #215 of 303 id: cord-304089-u2abo951 author: Trombetta, Claudia Maria title: Overview of Serological Techniques for Influenza Vaccine Evaluation: Past, Present and Future date: 2014-10-13 words: 10289 flesch: 29 summary: Sequential infection of mice simulates human experience The 2009 pandemic H1N1 virus induces anti-neuraminidase (NA) antibodies that cross-react with the NA of H5N1 viruses in ferrets Influenza neuraminidase antibodies provide partial protection for chickens against high pathogenic avian influenza infection A practical influenza neutralization assay to simultaneously quantify hemagglutinin and neuraminidase-inhibiting antibody responses Measurement of anti-influenza neuraminidase antibody using a peroxidase-linked lectin and microtitre plates coated with natural substrates Report from Scientific Workshop on Serology Assays and Correlates of Protection for Influenza Vaccines A vero cell-derived whole-virus H5N1 vaccine effectively induces neuraminidase-inhibiting antibodies Influenza virus-like particles as a new tool for vaccine immunogenicity testing: Validation of a neuraminidase neutralizing antibody assay Further studies of the neuraminidase content of inactivated influenza vaccines and the neuraminidase antibody responses after vaccination of immunologically primed and unprimed populations Effect of neuraminidase antibody on Hong Kong influenza Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses Neuraminidase-inhibiting antibody is a correlate of cross-protection against lethal H5N1 influenza virus in ferrets immunized with seasonal influenza vaccine Induction of partial immunity to influenza by a neuraminidase-specific vaccine Neuraminidase-specific antibody responses to inactivated influenza virus vaccine in young and elderly adults Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humans Immunization against influenza A virus: Comparison of conventional inactivated, live-attenuated and recombinant baculovirus produced purified hemagglutinin and neuraminidase vaccines in a murine model system Supplementation of conventional influenza A vaccine with purified viral neuraminidase results in a balanced and broadened immune response Recombinant soluble, multimeric HA and NA exhibit distinctive types of protection against pandemic swine-origin 2009 A(H1N1) influenza virus infection in ferrets Independent and disparate evolution in nature of influenza A virus hemagglutinin and neuraminidase glycoproteins Purified influenza virus hemagglutinin and neuraminidase are equivalent in stimulation of antibody response but induce contrasting types of immunity to infection Influenza hemagglutinin and neuraminidase membrane glycoproteins The role of antineuraminidase antibody in immunity to influenza virus infection Bridging the knowledge gaps in vaccine design Influenza vaccine immunology Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity The Influenza Viruses A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM vaccines and conventional vaccines Killer T cells in influenza Heterologous protection against lethal A/HongKong/156/97 (H5N1) influenza virus infection in C57BL/6 mice Preexisting influenza-specific CD4 + T cells correlate with disease protection against influenza challenge in humans Cell-mediated protection in influenza infection Considerations in the design of vaccines that induce CD8 T cell mediated immunity Influenza The purpose of this timely review is to highlight the current scenario on correlates of protection concerning influenza vaccines and underline the need to revise the criteria and assays currently in use. keywords: antibodies; antibody; assay; cell; h5n1; infection; influenza; neuraminidase; protection; response; titre; vaccination; vaccine; virus; viruses cache: cord-304089-u2abo951.txt plain text: cord-304089-u2abo951.txt item: #216 of 303 id: cord-304485-vouu56rr author: Bengoechea, Jose A title: Viruses to fight other viruses: the influenza vaccine case date: 2020-04-22 words: 1320 flesch: 35 summary: Adeno-associated virus-vectored influenza vaccine elicits neutralizing and Fcgamma receptor-activating antibodies Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection A new genetic vaccine platform based on an adeno-associated virus isolated from a rhesus macaque Vaccine protection against lethal homologous and heterologous challenge using recombinant AAV vectors expressing codon-optimized genes from pandemic swine origin influenza virus (SOIV) A perspective on the structural and functional constraints for immune evasion: insights from influenza virus A novel recombinant adeno-associated virus vaccine induces a longterm humoral immune response to human immunodeficiency virus AAV vector expressing influenza surface exposed antigens Testing in ferrets (model for human influenza infections) Demminger and colleagues developed AAV vectors expressing wild-type HA, the surface exposed neuraminidase (NA), or chimeric HA (cHA) containing head regions from influenza A virus subtypes, or HA headless constructs. keywords: aav; influenza; vaccine; virus cache: cord-304485-vouu56rr.txt plain text: cord-304485-vouu56rr.txt item: #217 of 303 id: cord-304569-o39kl5k4 author: Nguyen-Van-Tam, Jonathan S title: From the Editor's desk date: 2015-04-23 words: 1211 flesch: 39 summary: Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data Oseltamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials Effectiveness of H1N1 vaccine for the prevention of pandemic influenza in Scotland, UK: a retrospective observational cohort study Effects of vaccine program against pandemic influenza A(H1N1) virus, United States Pandemic influenza viruses--hoping for the road not taken Avian influenza A H10N8--a virus on the verge? Evidence for camel-to-human transmission of MERS coronavirus MERS-CoV outbreak in Jeddah -a link to health care facilities Hospital outbreak of Middle East respiratory syndrome coronavirus Transmission of MERScoronavirus in household contacts High frequency of enterovirus D68 in children hospitalised with respiratory illness in Norway Low effectiveness of seasonal influenza vaccine in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2014/15 mid-season results Excess mortality among the elderly in European countries Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement In amongst this mix are real issues pertaining to the ongoing controversy about the effectiveness of antiviral drugs, [1] [2] [3] ; and the fact that current vaccine manufacturing platforms can only offer commercial quantities of pandemic vaccine some four to 6 months after a novel virus has emerged, thus substantially reducing the overall public health benefits, even though vaccines themselves are effective. keywords: influenza; pandemic; peer; review cache: cord-304569-o39kl5k4.txt plain text: cord-304569-o39kl5k4.txt item: #218 of 303 id: cord-304870-j9kadxu9 author: Chen, Gongbo title: The impact of ambient fine particles on influenza transmission and the modification effects of temperature in China: A multi-city study date: 2016-10-11 words: 4349 flesch: 37 summary: Influenza data Daily data of influenza cases for 47 cities in China from September 9, 2013 to December 31, 2014 were obtained from the China Information System for Disease Control and Prevention (CISDCP). Influenza cases were defined according to Technical guides for prevention and control of influenza issued by China Ministry of Health (http://www.moh.gov.cn/zwgkzt/s9491/200802/38820.shtml): sudden onset of fever ≥ 38°C, cough or sore throat, and absence of other diagnoses. keywords: ambient; china; days; influenza; lag; temperature cache: cord-304870-j9kadxu9.txt plain text: cord-304870-j9kadxu9.txt item: #219 of 303 id: cord-305936-tdswzj7r author: Freitas, André Ricardo Ribas title: Excess of Mortality in Adults and Elderly and Circulation of Subtypes of Influenza Virus in Southern Brazil date: 2018-01-08 words: 4346 flesch: 31 summary: Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP) Influenza and the winter increase in mortality in the United States, 1959-1999 Impact of respiratory virus infections on persons with chronic underlying conditions Epidemiology of seasonal influenza: use of surveillance data and statistical models to estimate the burden of disease Influenza-related hospitalizations among children in Hong Kong Trends in mortality from respiratory diseases among the elderly and the influenza vaccine intervention Mortality associated with influenza in tropics, state of Sao Paulo, Brazil, from 2002 to 2011: the pre-pandemic, pandemic, and post-pandemic periods Influenza-related deaths -available methods for estimating numbers and detecting patterns for seasonal and pandemic influenza in Europe Excess mortality associated with influenza epidemics in Portugal Time series methods for obtaining excess mortality attributable to influenza epidemics Influenza associated mortality in the subtropics and tropics: results from three Asian cities Influenza in tropical regions Seasonality of influenza in Brazil: a traveling wave from the Amazon to the subtropics Methods for current statistical analysis of excess pneumonia-influenza deaths Impact of influenza vaccination on seasonal mortality in the US elderly population Influenza-related mortality in Spain Is influenza-like illness a useful concept and an appropriate test of influenza vaccine effectiveness? Estimates of US influenza-associated deaths made using four different methods Mortality associated with influenza and respiratory syncytial virus in the United States Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic The global circulation of seasonal influenza A (H3N2) viruses Comparing clinical characteristics between hospitalized adults with laboratory-confirmed influenza A and B virus infection Trends in mortality from respiratory disease in Latin America since 1998 and the impact of the 2009 influenza pandemic Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study T cell mediated immunity to influenza: mechanisms of viral control T-cell immunity to influenza in older adults: a pathophysiological framework for development of more effective vaccines A question of self-preservation: immunopathology in influenza virus infection Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review Acute respiratory tract infections: a potential trigger for the acute coronary syndrome Influenza and atherosclerosis: vaccination for cardiovascular disease prevention Multiple immunological abnormalities in patients with type 1 (insulin dependent) diabetes mellitus Use of influenza and pneumococcal vaccines in people with diabetes Mortality attributable to influenza in England and Wales prior to, during and after the 2009 pandemic Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis Pandemic H1N1 influenza in Brazil: analysis of the first 34,506 notified cases of influenza-like illness with severe acute respiratory infection (SARI) Pandemic versus epidemic influenza mortality: a pattern of changing age distribution Epidemiology of influenza and its control Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): role of the host immune response in pathogenesis Crossreactive antibody responses to the 2009 pandemic H1N1 influenza virus The evolution of human influenza A viruses from 1999 to 2006: a complete genome study Molecular evolution of human influenza A/H3N2 virus in Asia and Europe from 2001 to Molecular characterization of influenza viruses collected from young children in Uberlandia, Brazil-from Virus influenza detectados no estado do Rio Grande do Sul durante Center for Disease Control and Prevention. keywords: age; elderly; excess; influenza; mortality; pandemic; virus; years cache: cord-305936-tdswzj7r.txt plain text: cord-305936-tdswzj7r.txt item: #220 of 303 id: cord-306983-6w2fvtfy author: Wang, Siye title: Influenza Virus—Cytokine-Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza date: 2010-10-01 words: 3817 flesch: 34 summary: A possible activator of the viral fusion glycoprotein Activation of influenza A viruses by trypsin treatment Trypsin action on the growth of Sendai virus in tissue culture cells: structural difference of Sendai viruses grown in eggs and tissue culture cells Identification of biological activity of paramyxovirus glycoprotein: activation of cell fusion, hemolysis and infectivity by proteolytic cleavage of an inactive precursor protein of Sendai virus The molecular of influenza virus pathogenicity Proteases essential for human influenza virus entry into cells and their inhibitors as potential therapeutic agents Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses Human matrix metalloproteinase-9: activation by limited trypsin treatment and generation of monoclonal antibodies specific for the activated form Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury Neuropathogenesis of influenza virus infection in mice Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy Treatment with inhibitors of the NF-kB pathway improves whole body tension development in the mdx mouse These findings suggest that cytokines upregulate trypsin in vascular endothelial cells and that secreted trypsin plays an (original magnification, ϫ200) . keywords: brain; cells; cytokines; figure; human; infection; influenza; tnf; trypsin; vascular; virus cache: cord-306983-6w2fvtfy.txt plain text: cord-306983-6w2fvtfy.txt item: #221 of 303 id: cord-307607-8xn9jtmh author: Sargin, Seyid Ahmet title: Potential anti-influenza effective plants used in Turkish folk medicine: A review date: 2020-08-31 words: 7074 flesch: 43 summary: In this context, approximately 700 articles conducted between January 1977 and February 2020 throughout Turkey were excluded since they did not meet the inclusion criteria and a consensus has been provided among the 81 works on the determination of medicinal plants used by local people for centuries. Besides, it can never be ignored that medicinal plants are very successful in preventing and treating influenza if used according to the prescriptions specified in their pharmacopoeia. keywords: activity; anatolia; anti; et al; influenza; oil; parts; plants; studies; study; table; taxa; treatment; turkey; virus cache: cord-307607-8xn9jtmh.txt plain text: cord-307607-8xn9jtmh.txt item: #222 of 303 id: cord-307813-elom30nx author: Yip, Tsz-Fung title: Advancements in Host-Based Interventions for Influenza Treatment date: 2018-07-10 words: 15110 flesch: 27 summary: Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency Disease-promoting effects of type I interferons in viral, bacterial, and coinfections Protection from lethal influenza virus challenge by oral type 1 interferon Low-dose oral interferon alpha as prophylaxis against viral respiratory illness: a double-blind, parallel controlled trial during an influenza pandemic year IFNlambda is a potent anti-influenza therapeutic without the inflammatory side effects of IFNalpha treatment Pathogenic potential of interferon alphabeta in acute influenza infection The superiority of IFN-lambda as a therapeutic candidate to control acute influenza viral lung infection Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of gammadelta T cells Interferon-lambda mediates non-redundant front-line antiviral protection against influenza virus infection without compromising host fitness RIG-I activation protects and rescues from lethal influenza virus infection and bacterial superinfection Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro Avian influenza A H7N9 virus induces severe pneumonia in mice without prior adaptation and responds to a combination of zanamivir and COX-2 inhibitor Role of cyclooxygenase-2 in H5N1 viral pathogenesis and the potential use of its inhibitors Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages Modified Jiu Wei Qiang Huo decoction improves dysfunctional metabolomics in influenza A pneumoniainfected mice Pattern recognition receptors and inflammation Cutting edge: There is an urgent need to search for alternative targets to treat influenza virus infections, including non-viral targets such as host cellular factors; which are promising as viruses rely on the host machinery for replication. keywords: addition; antiviral; cells; complex; drug; export; host; human; iav; immune; infected; infection; influenza; inhibitor; lung; membrane; mice; nuclear; production; protein; replication; role; treatment; type; viral; virus; viruses; vitro; vrnp cache: cord-307813-elom30nx.txt plain text: cord-307813-elom30nx.txt item: #223 of 303 id: cord-307918-8y89p11a author: Onyango, Clayton O. title: Influenza Surveillance Among Children With Pneumonia Admitted to a District Hospital in Coastal Kenya, 2007–2010 date: 2012-12-15 words: 3681 flesch: 40 summary: The prevalence of influenza virus of any type was 4.9% (99 of 2002 cases) among inpatients; 4.7% (76 of 1615) had severe pneumonia, and 5.9% (23 of 387) had very severe pneumonia (P = .299). Among outpatients, the prevalence of influenza virus of any type was 3.9% (13 of 331) among those with URTI and 0.5% (1 of 196) among those with non-ARI. keywords: age; cases; children; hospital; incidence; infection; influenza; pneumonia; virus cache: cord-307918-8y89p11a.txt plain text: cord-307918-8y89p11a.txt item: #224 of 303 id: cord-309381-cb80ntxs author: Nogales, Aitor title: Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans date: 2019-09-30 words: 10240 flesch: 40 summary: Just as an example mentioned below, IFITM3 is an ISG playing antiviral roles against influenza virus infection and other viruses [59] . B influenza viruses: Basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 northern hemisphere season Prevention and Control of Seasonal Influenza with Vaccines The annual impact of seasonal influenza in the US: Measuring disease burden and costs The continual threat of influenza virus infections at the human-animal interface: What is new from a one health perspective? keywords: allele; cells; disease; expression; gene; host; human; iav; ifitm3; infection; influenza; nucleotide; polymorphisms; protein; receptor; responses; risk; snps; susceptibility; type; virus; viruses cache: cord-309381-cb80ntxs.txt plain text: cord-309381-cb80ntxs.txt item: #225 of 303 id: cord-309635-1tgovkr7 author: Wu, Nicholas C. title: Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure date: 2020-09-22 words: 5518 flesch: 33 summary: A group 1 and 2 hemagglutinins through a further variation in V H 1-69 antibody orientation on the HA stem Rapid development of broadly influenza neutralizing antibodies through redundant mutations Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses Recurring and adaptable binding motifs in broadly neutralizing antibodies to influenza virus are encoded on the D3-9 segment of the Ig gene A highly conserved neutralizing epitope on group 2 influenza A viruses A common solution to group 2 influenza virus neutralization Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses Structure and function analysis of an antibody recognizing all influenza A subtypes Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans Convergent evolution in breadth of two V H 6-1-encoded influenza antibody clonotypes from a single donor Cross-neutralization of influenza A viruses mediated by a single antibody loop Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus Naturally occurring antibodies in humans can neutralize a variety of influenza virus strains, including H3, H1, H2, and H5 Memory B cells that cross-react with group 1 and group 2 influenza A viruses are abundant in adult human repertoires Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity Cross-protective potential of a novel monoclonal antibody directed against antigenic site B of the hemagglutinin of influenza A viruses Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody H7N9 influenza virus neutralizing antibodies that possess few somatic mutations Fine antigenic variation within H5N1 influenza virus hemagglutinin's antigenic sites defined by yeast cell surface display Conserved neutralizing epitope at globular head of hemagglutinin in H3N2 influenza viruses Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface Antibodies to a conserved influenza head interface epitope protect by an IgG subtype-dependent mechanism Influenza antigen engineering focuses immune responses to a subdominant but broadly protective viral epitope Direct visualization of the conformational dynamics of single influenza hemagglutinin trimers Inhibition of the fusion-inducing conformational change of influenza hemagglutinin by benzoquinones and hydroquinones Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion Characteristics of arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol Design of inhibitors of influenza virus membrane fusion: Synthesis, structure-activity relationship and in vitro antiviral activity of a novel indole series Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin Computational design of proteins targeting the conserved stem region of influenza hemagglutinin Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing Massively parallel de novo protein design for targeted therapeutics Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site Potent peptidic fusion inhibitors of influenza virus A small-molecule fusion inhibitor of influenza virus is orally active in mice An influenza Four types of influenza virus, A, B, C, and D, are known. keywords: antibodies; antibody; binding; fusion; hemagglutinin; influenza; receptor; stem; structure; virus; viruses cache: cord-309635-1tgovkr7.txt plain text: cord-309635-1tgovkr7.txt item: #226 of 303 id: cord-309860-otx45b8x author: Conway, Nicholas T. title: Clinical Predictors of Influenza in Young Children: The Limitations of “Influenza-Like Illness” date: 2012-09-03 words: 3742 flesch: 40 summary: Influenza disease surveillance usually includes a combination of community-and hospital-based syndromic surveillance and routinely collected data concerning morbidity and mortality, with only some including laboratory confirmation of influenza infection. Influenza-like illness is a poor predictor of actual influenza infection in adults, despite attempts to improve the accuracy of the definition [8] , but there is limited data on the reliability of ILI in predicting influenza infection in children keywords: age; children; definition; fever; ili; infection; influenza; study cache: cord-309860-otx45b8x.txt plain text: cord-309860-otx45b8x.txt item: #227 of 303 id: cord-310182-muybvyqa author: Fan, Victoria Y title: Pandemic risk: how large are the expected losses? date: 2018-02-01 words: 4314 flesch: 49 summary: A history of influenza The chronicle of influenza epidemics Introduction to pandemic influenza through history Modelling a modern-day Spanish flu pandemic The population of India and Pakistan Influenza in India 1918: excess mortality reassessed Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysis Observations on mortality during the 1918 influenza pandemic Characterizing the amount and speed of discounting procedures Expert judgments of pandemic influenza risks Preparing for the next pandemic Climate Change Temperature impacts on economic growth warrant stringent mitigation policy. World Bank The loss from pandemic influenza risk keywords: costs; estimates; global; income; influenza; losses; mortality; national; pandemic; probability; risk; studies; value cache: cord-310182-muybvyqa.txt plain text: cord-310182-muybvyqa.txt item: #228 of 303 id: cord-310956-qwe4ndvb author: Qian, Yan‐Hua title: Attempted early detection of influenza A (H1N1) pandemic with surveillance data of influenza‐like illness and unexplained pneumonia date: 2011-04-18 words: 3705 flesch: 48 summary: Emerging infections: pandemic influenza World now at the start of 2009 influenza pandemic Mortality from pandemic A ⁄ H1N1 2009 influenza in England: public health surveillance study Guideline for prevention and control of influenza Statistical quality control methods in infection control and hospital epidemiology, Part II: chart use, statistical properties, and research issues Statistical quality control methods in infection control and hospital epidemiology, part I: introduction and basic theory Study on early warning based on influenza surveillance data in Guangdong province Methods for current statistical analysis of excess pneumonia-influenza deaths Time-Series Forecasting Use and interpretation of statistical quality control charts Influenza-associated hospitalizations in the United States Impact of influenza vaccination on seasonal mortality in the US elderly population Can syndromic thresholds provide early warning of national influenza outbreaks? Methods for monitoring influenza surveillance data Trends and Directions of Global Public Health Surveillance The impact of influenza epidemics on hospitalizations Value of ICD-9-coded chief complaints for detection of epidemics Performance of a syndromic system for influenza based on the activity of general practitioners, France Situational uses of syndromic surveillance Sensitivity, specificity and predictive values of health service based indicators for the surveillance of influenza a epidemics Comparing aberration detection methods with simulated data A simulation model for assessing aberration detection methods used in public health surveillance for systems with limited baselines Review of an influenza surveillance system, Beijing, People's Republic of China Disease surveillance using a hidden Markov model The emerging science of very early detection of disease outbreaks The ILI system was implemented for influenza surveillance, and the UP system was designed to track lower respiratory illness with pneumonia symptoms. keywords: control; data; ili; influenza; method; surveillance; week cache: cord-310956-qwe4ndvb.txt plain text: cord-310956-qwe4ndvb.txt item: #229 of 303 id: cord-311115-nimxnf6s author: Bednarska, K. title: Antigenic Drift of A/H3N2/Virus and Circulation of Influenza-Like Viruses During the 2014/2015 Influenza Season in Poland date: 2016-03-09 words: 1183 flesch: 45 summary: They contain two subtypes of influenza virus A and one lineage of influenza virus type B. During that season, antigenic drift of influenza virus A/H3N2/ occurred causing higher rates of A/H3N2/ infections. keywords: influenza; season; viruses cache: cord-311115-nimxnf6s.txt plain text: cord-311115-nimxnf6s.txt item: #230 of 303 id: cord-312461-5qzpo6l1 author: Adalja, Amesh A. title: Characteristics of Microbes Most Likely to Cause Pandemics and Global Catastrophes date: 2019-08-30 words: 6830 flesch: 35 summary: Other factors that may increase a virus' potential to cause a global catastrophic risk include a segmented genome (as exemplified by influenza viruses), a comparatively smaller genome size, and high host viremia (e.g., vector-borne flaviviruses). Nontraditional molecules, such as monoclonal antibodies and immunomodulators, should also be investigated for a role in the treatment and prevention of RNA virus respiratory infections (Walker and Burton 2018) . keywords: cause; disease; human; influenza; microbe; pandemic; preparedness; respiratory; risk; rna; spread; transmission; viruses cache: cord-312461-5qzpo6l1.txt plain text: cord-312461-5qzpo6l1.txt item: #231 of 303 id: cord-312493-wbhji81g author: Tay, Ee Laine title: Exploring a Proposed WHO Method to Determine Thresholds for Seasonal Influenza Surveillance date: 2013-10-11 words: 4305 flesch: 45 summary: Flu Activity & Surveillance: Weekly US Influenza Surveillance Report Weekly Influenza Surveillance Overview In: Control Establishing thresholds for influenza surveillance in Victoria Can syndromic thresholds provide early warning of national influenza outbreaks? Methods for monitoring influenza surveillance data A routine tool for detection and assessment of epidemics of influenza-like syndromes in France A statistical algorithm for the early detection of outbreaks of infectious disease Epidemic features affecting the performance of outbreak detection algorithms Influenza surveillance in Europe: establishing epidemic thresholds by the Moving Epidemic Method Modelling influenza epidemic -can we detect the beginning and predict the intensity and duration? Detection of epidemics in their early stage through infectious disease surveillance Do CuSums have a role in routine communicable disease surveillance? Detecting the start of an influenza outbreak using exponentially weighted moving average charts Overview of Influenza Surveillance in the United States Laboratory-supported influenza surveillance in Victorian sentinel general practices Estimation of influenza vaccine effectiveness from routine surveillance data A medical locum service as a site for sentinel influenza surveillance Influenza-like illness surveillance using a deputising medical service corresponds to surveillance from sentinel general practices Laboratory diagnosis and surveillance of human respiratory viruses by PCR in H1N1 swine origin influenza infection in the United States and Europe in 2009 may be similar to H1N1 seasonal influenza infection in two Australian states in A comparison of data sources for the surveillance of seasonal and pandemic influenza in Victoria Influenza surveillance in Australia: we need to do more than count The use of thresholds to describe levels of influenza activity An Analysis of Variance Test for Normality (Complete Samples) Improving the Estimation of Influenza-Related Mortality Over a Seasonal Baseline Predicting the epidemic sizes of influenza A/H1N1, A/H3N2, and B: a statistical method The significance of increased influenza notifications during spring and summer of 2010-11 in Australia Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009 The aim of this study was to explore the feasibility of the WHO method for the calculation of influenza thresholds using a range of existing surveillance and laboratory data sources in one surveillance system. keywords: data; datasets; ili; influenza; laboratory; peak; season; surveillance; thresholds cache: cord-312493-wbhji81g.txt plain text: cord-312493-wbhji81g.txt item: #232 of 303 id: cord-313062-lpxmmbpy author: Amini, Rachid title: Respiratory syncytial virus contributes to more severe respiratory morbidity than influenza in children < 2 years during seasonal influenza peaks date: 2019-02-23 words: 2620 flesch: 42 summary: Respiratory syncytial virus (RSV) and influenza virus infections are considered as leading cause of hospitalization among infants and young children [1, 2] . We detected higher frequency of RSV compared to influenza viruses (55.3% vs. 16.3%). keywords: children; influenza; months; rsv; study cache: cord-313062-lpxmmbpy.txt plain text: cord-313062-lpxmmbpy.txt item: #233 of 303 id: cord-313693-qmkrn7pr author: Wong, Bonnie C. K. title: Possible Role of Aerosol Transmission in a Hospital Outbreak of Influenza date: 2010-11-15 words: 4204 flesch: 42 summary: Pandemic (H1N1) Infection prevention and control in health care for confirmed or suspected cases of pandemic (H1N1) 2009 and influenza-like illnesses Interim guidance on infection control measures for 2009 H1N1 influenza in healthcare settings, including protection of healthcare personnel Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review Surgical mask vs N95 respirator Aerosol Transmission of Influenza • CID 2010:51 (15 November) • 1183 for preventing influenza among health care workers: a randomized trial Novel H1N1 influenza and respiratory protection for health care workers Transmission of influenza A in human beings Evidence of airborne transmission of the severe acute respiratory syndrome virus Temporal-spatial analysis of severe acute respiratory syndrome among hospital inpatients Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units Role of ventilation in airborne transmission of infectious agents in the built environment-a multidisciplinary systematic review Review of aerosol transmission of influenza A virus Aerosol transmission of influenza A virus: a review of new studies Outcomes of adults hospitalized with severe influenza Factors associated with early hospital discharge of adult influenza patients A major outbreak of severe acute respiratory syndrome in Hong Kong Seasonality of influenza A(H3N2) virus: a Hong Kong perspective Lack of cross-immune reactivity against influenza H5N1 from seasonal influenza vaccine in humans Fluent 6.2 user's guide Removal of exhaled particles by ventilation and deposition in a multibed airborne infection isolation room How far droplets can move in indoor environments-revisiting Wells evaporation-falling curve of droplets Exhaled air dispersion distances during noninvasive ventilation via different respironics face masks Noninvasive positive-pressure ventilation: an experimental model to assess air and particle dispersion Exhaled air dispersion during oxygen delivery via a simple oxygen mask The guinea pig as a transmission model for human influenza viruses Transmission of influenza virus via aerosols and fomites in the guinea pig model Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice Measurement of airborne influenza virus in a hospital emergency department Influenza virus in human exhaled breath: an observational study Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada Possible SARS coronavirus transmission during cardiopulmonary resuscitation Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others? Cross-sectional and longitudinal factors predicting influenza vaccination in Hong Kong Chinese elderly aged 65 and above Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys Influenza virus transmission is dependent on relative humidity and temperature Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises Under natural conditions, influenza virus is transmitted predominantly via droplets and direct contact [13] . keywords: aerosol; air; bay; infection; influenza; outbreak; patients; transmission; virus; ward cache: cord-313693-qmkrn7pr.txt plain text: cord-313693-qmkrn7pr.txt item: #234 of 303 id: cord-314607-bcocsjij author: Memish, Ziad A. title: The prevalance of respiratory viruses among healthcare workers serving pilgrims in Makkah during the 2009 influenza A (H1N1) pandemic date: 2011-12-23 words: 3489 flesch: 48 summary: The pre-Hajj questionnaire was about demographics (age, sex, occupation, and nationality), medical history (chronic disease and smoking), vaccination history (including H1N1 and seasonal influenza), and knowledge of H1N1 influenza (symptoms, transmission, and prevention). Demographics, medical history, vaccination history, knowledge of H1N1 influenza, and compliance with infection control practices are presented as frequencies. keywords: h1n1; hajj; healthcare; infections; influenza; pilgrims; rhinovirus; workers cache: cord-314607-bcocsjij.txt plain text: cord-314607-bcocsjij.txt item: #235 of 303 id: cord-315339-dcui85lw author: Broadbent, Andrew J. title: Respiratory Virus Vaccines date: 2015-03-13 words: 28291 flesch: 26 summary: Type I interferons keep activated T cells alive A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a phase I clinical trial Antigenic structure of the human respiratory syncytial virus G glycoprotein and relevance of hypermutation events for the generation of antigenic variants The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta Subcellular localization of Toll-like receptor 3 in human dendritic cells The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFNgamma production AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people Regulation of IgA synthesis and immune response by T cells and interleukins Innate immune control and regulation of influenza virus infections IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells Memory CD4 + T cells protect against influenza through multiple synergizing mechanisms Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes The human cytotoxic T cell response to influenza A vaccination Adaptive strategies of the influenza virus polymerase for replication in humans Live attenuated influenza vaccine induces cross-reactive antibody responses in children against an a/Fujian/411/2002-like H3N2 antigenic variant strain Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response Intestinal IgA: novel views on its function in the defence of the largest mucosal surface The influence of HIV infection on antibody responses to a two-dose regimen of influenza vaccine Human genetic factors and respiratory syncytial virus disease severity Oral immunization with influenza virus in biodegradable microspheres Human immune responses to influenza virus vaccines administered by systemic or mucosal routes Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17 Comparative efficacy of inactivated and live attenuated influenza vaccines Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude ISCOM, a delivery system for parenteral and mucosal vaccination Adjuvant system AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity H5N1 influenza vaccine formulated with AS03 A induces strong crossreactive and polyfunctional CD4 T-cell responses Roles of CD4 + T-cell-independent and -dependent antibody responses in the control of influenza virus infection: evidence for noncognate CD4 + T-cell activities that enhance the therapeutic activity of antiviral antibodies Antigenicity and immunogenicity of equine influenza vaccines containing a carbomer adjuvant The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses Formalin-inactivated respiratory syncytial virus vaccine induces antibodies to the fusion glycoprotein that are deficient in fusion-inhibiting activity Association of serum anti-neuraminidase antibody with resistance to influenza in man Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam Systems biology of vaccination for seasonal influenza in humans Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) induced IgG1 and IgG4 antibody responses in young children Mucosal vaccines: the promise and the challenge Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8 + cytotoxic T lymphocytes Gamma interferon is not required for mucosal cytotoxic T-lymphocyte responses or heterosubtypic immunity to influenza A virus infection in mice Heterosubtypic immunity to influenza A virus infection requires B cells but not CD8 + cytotoxic T lymphocytes Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigenspecific immune responses A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells Endogenous naive CD8 + T cell precursor frequency regulates primary and memory responses to infection Vaccination strategies for mucosal immune responses Recent developments in adjuvants for vaccines against infectious diseases Prevention of antigenically drifted influenza by inactivated and live attenuated vaccines Prevention of symptomatic seasonal influenza in 2005-2006 by inactivated and live attenuated vaccines Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains Protection against the mouse-adapted A/FM/1/47 strain of influenza A virus in mice by a monoclonal antibody with cross-neutralizing activity among H1 and H2 strains Efficacy and effectiveness of influenza vaccines: a systematic review and metaanalysis Effect of priming with H1N1 influenza viruses of variable antigenic distances on challenge with 2009 pandemic H1N1 virus Orthomyxoviridae: the viruses and their replication The majority of studies evaluating respiratory virus vaccines measure serum antibody responses, because, although both cellular and humoral responses contribute to the clearance of a primary infection, neutralizing antibodies are known to protect against secondary infection. keywords: addition; antibodies; antibody; antibody responses; antigen; cd4; cd8; cell responses; cells; challenge; children; disease; et al; host; human; iga; immune; immunity; infection; influenza; influenza infection; influenza vaccines; influenza virus; live; mice; mucosal; protection; protein; replication; responses; rsv; sars; serum; specific; syncytial; t cells; tract; type; vaccination; vaccine; virus; virus infection; virus vaccine; viruses cache: cord-315339-dcui85lw.txt plain text: cord-315339-dcui85lw.txt item: #236 of 303 id: cord-316217-ynh8d853 author: Yoshihara, Keisuke title: Influenza B associated paediatric acute respiratory infection hospitalization in central vietnam date: 2019-02-28 words: 2734 flesch: 26 summary: The evolutionary dynamics of human influenza B virus Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes Molecular epidemiologic and clinical characteristics of influenza B-associated complications among hospitalized patients during an outbreak in Taiwan Phylogenetic and evolutionary history of influenza B viruses Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983 Epidemiological and virological characteristics of influenza viruses circulating in Cambodia from Differing epidemiological dynamics of influenza B virus lineages in Guangzhou, southern China Local persistence and global dissemination play a significant role in the circulation of influenza B viruses in Leyte Island Molecular Epidemiology and Phylogenetic Analyses of Influenza B Virus in Thailand during Viral pathogens associated with acute respiratory infections in central vietnamese children Integrated approach to child health in developing countries Burden of disease caused by Haemophilus influenzae type b in children younger than 5 years: global estimates Genetic analysis of influenza B viruses isolated in Uganda during the 2009-2010 seasons Kakusan4 and Aminosan: two programs for comparing nonpartitioned, proportional and separate models for combined molecular phylogenetic analyses of multilocus sequence data MEGA6: molecular evolutionary genetics analysis version 6.0 Interrupted time series regression for the evaluation of public health interventions: a tutorial Time series regression studies in environmental epidemiology Impact of 2009 pandemic influenza among Vietnamese children based on a population-based prospective surveillance from 2007 to 2011. The gene structure and replication of influenza virus Influenza B lineage circulation and hospitalization rates in a subtropical city Surveillance and molecular characterization of human influenza B viruses during 2006-2010 revealed co-circulation of Yamagata-like and Victoria-like strains in eastern India Epidemiology and seasonality of respiratory tract virus infections in the tropics Influenza surveillance in Indonesia Influenza viruses in Thailand: 7 years of sentinel surveillance data Epidemiological and virological characteristics of influenza in the Western Pacific Region of the World Health Organization Influenza B virus genome: assignment of viral polypeptides to RNA segments Influenza B virus in seals Epidemiological, antigenic and genetic characteristics of seasonal influenza A(H1N1), A(H3N2) and B influenza viruses: basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 northern hemisphere season Reassortment and insertion-deletion are strategies for the evolution of influenza B viruses in nature keywords: ari; children; clinical; influenza; lineage; victoria; virus cache: cord-316217-ynh8d853.txt plain text: cord-316217-ynh8d853.txt item: #237 of 303 id: cord-318556-a28bowqy author: Kuliese, Monika title: Seasonal influenza vaccine effectiveness against laboratory-confirmed influenza in 2015–2016: a hospital-based test-negative case–control study in Lithuania date: 2017-10-10 words: 4292 flesch: 37 summary: The study population consisted of 18 years and older individuals with underlying medical conditions, healthy ≥65 years old individuals and pregnant women living in the community, who were admitted to one of the participating sites due to SARI with no contraindication for influenza vaccination, that is, allergies to influenza vaccine and other adverse events to vaccinations in the past. Influenza cases had significantly less underlying medical conditions, such as cardiovascular and lung diseases, were less often hospitalised during the last 12 months due to the exacerbations of the underlying illnesses, and were prescribed oseltamivir twice more often (table 1) . keywords: cases; effectiveness; influenza; patients; season; sive; study; vaccination; vaccine cache: cord-318556-a28bowqy.txt plain text: cord-318556-a28bowqy.txt item: #238 of 303 id: cord-318696-jheb2fnn author: Kesic, Matthew J. title: Exposure to Ozone Modulates Human Airway Protease/Antiprotease Balance Contributing to Increased Influenza A Infection date: 2012-04-09 words: 8666 flesch: 36 summary: This correlates with the increase in protease expression post ozone exposure ( Figure 5B ), viral entry (Figure 4) , and viral replication ( Figure 1C and 1D ). Similarly, by analyzing the apical washes for influenza viral titers 24 h post-infection, we saw a significant increase in viral titers in ozone exposed cells as compared to the control ( Figure 1D ). keywords: cells; cleavage; exposure; expression; figure; infection; influenza; necs; ozone; post; protease; protein; replication; slpi; stress; virus cache: cord-318696-jheb2fnn.txt plain text: cord-318696-jheb2fnn.txt item: #239 of 303 id: cord-318753-ribybqfo author: Kwok, C. S. title: Influenza, influenza‐like symptoms and their association with cardiovascular risks: a systematic review and meta‐analysis of observational studies date: 2015-05-04 words: 4086 flesch: 35 summary: The most reliable diagnostic methodology is laboratory serological tests, as other chest infections or atypical respiratory infections may have clinical features consistent with influenza infection. However, even when serological tests were used to ascertain influenza infection, it is possible that patients who did not have serology positive influenza did not have flu and this may account for the dissimilarity between the two large cohorts evaluating public health records and the remaining studies. keywords: illness; infection; influenza; risk; studies; study; symptoms cache: cord-318753-ribybqfo.txt plain text: cord-318753-ribybqfo.txt item: #240 of 303 id: cord-322082-80ym2rsq author: Monto, Arnold S title: Lessons From Influenza Pandemics of the Last 100 Years date: 2020-03-01 words: 4089 flesch: 41 summary: Influenza viruses were first isolated in the 1930s, and the etiology and timing of previous activity were based on testing of sera from individuals who had lived through the period in question. That tantalizing observation has been used recently to strengthen the suggestion that small-particle aerosol transmission of influenza viruses is of importance. keywords: a(h1n1; human; influenza; mortality; pandemic; vaccine; virus; viruses cache: cord-322082-80ym2rsq.txt plain text: cord-322082-80ym2rsq.txt item: #241 of 303 id: cord-322906-zef971xp author: Hochman, Assaf title: The relationship between cyclonic weather regimes and seasonal influenza over the Eastern Mediterranean date: 2020-08-12 words: 3291 flesch: 35 summary: Next, we quantify the relationship between the meteorological variables and seasonal Influenza occurrence in Israel. A plethora of studies have indicated that the timing of seasonal Influenza varies across latitude, thus suggesting that meteorological conditions play an important role in the transmission of the disease (Soebiyanto et al., 2010; 2014; Tang et al., 2010; Baumgartner et al., 2012; Shaman and Karspeck 2012; Yang et al., 2012; Tamerius et al., 2013; Yaari et al., 2013; keywords: climate; cyprus; et al; influenza; occurrence; weather cache: cord-322906-zef971xp.txt plain text: cord-322906-zef971xp.txt item: #242 of 303 id: cord-323987-gh1m05gi author: Dziąbowska, Karolina title: Detection Methods of Human and Animal Influenza Virus—Current Trends date: 2018-10-18 words: 11146 flesch: 43 summary: Influenza Other Respir Bioassay Development for Ultrasensitive Detection of Influenza A Nucleoprotein Using Digital ELISA Highly sensitive colorimetric immunosensor for influenza virus H5N1 based on enzyme-encapsulated liposome A highly sensitive europium nanoparticle-based immunoassay for detection of influenza A/B virus antigen in clinical specimens Identification and subtyping of avian influenza viruses by reverse transcription-PCR Evaluation of saliva as diagnostic materials for influenza virus infection by PCR-based assays Nucleic acid dipstick test for molecular diagnosis of pandemic H1N1 Development and evaluation of a real-time nucleic acid sequence based amplification assay for rapid detection of influenza A Detection of human influenza A viruses by loop-mediated isothermal amplification Development and evaluation of reverse transcription loop-mediated isothermal amplification assay for rapid and real-time detection of the swine-origin influenza A H1N1 virus Comparison of Next-Generation Sequencing Systems A tale of three next generation sequencing platforms: Comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing Electrochemical Sensors for Detections of Influenza Viruses: Fundamentals and Applications Novel Nano Biosensor Developed for Rapid Detection of Flu Virus Applying the miniaturization technologies for biosensor design Rapid detection for primary screening of influenza A virus: Microfluidic RT-PCR chip and electrochemical DNA sensor Use of semiconductor-based oligonucleotide microarrays for influenza a virus subtype identification and sequencing Detection of viruses with molecularly imprinted polymers integrated on a microfluidic biochip using contact-less dielectric microsensors Evaluation of a smartphone-based rapid fluorescent diagnostic system for H9N2 virus in specific-pathogen-free chickens A paper-based microfluidic Dot-ELISA system with smartphone for the detection of influenza A. Microfluid Electrochemical assay to detect influenza viruses and measure drug susceptibility The phenomenon of fluorescence in immunosensors Electrochemical Sensors and Biosensors for Influenza Detection-Literature Survey Direct and label-free influenza virus detection based on multisite binding to sialic acid receptors A rapid-response ultrasensitive biosensor for influenza virus detection using antibody modified boron-doped diamond A PCR-free point-of-care capacitive immunoassay for influenza A virus Electrochemical immunosensor for detection of antibodies against influenza A virus H5N1 in hen serum An amplified electrochemical immunosensor based on in situ-produced 1-naphthol as electroactive substance and graphene oxide and Pt nanoparticles functionalized CeO2 nanocomposites as signal enhancer Dual immunosensor based on methylene blue-electroadsorbed graphene oxide for rapid detection of the influenza A virus antigen Label-free Detection of Influenza Viruses using a Reduced Graphene Oxide-based Electrochemical Immunosensor Integrated with a Microfluidic Platform Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide Universal biosensor for detection of influenza virus Electrochemical Biosensing for the Diagnosis of Viral Infections and Tropical Diseases Electrochemical biosensing of influenza A subtype genome based on meso/macroporous cobalt (II) oxide nanoflakes-applied to human samples Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections Amperometric bioaffinity sensing platform for avian influenza virus proteins with aptamer modified gold nanoparticles on carbon chips Carbon nanotag based visual detection of influenza A virus by a lateral flow immunoassay In situ self-assembly of gold nanoparticles on hydrophilic and hydrophobic substrates for influenza virus-sensing platform Highly Uniform Gold Nanobipyramids for Ultrasensitive Colorimetric Detection of Influenza Virus Hewlett, I. Sensitive detection of influenza viruses with Europium nanoparticles on an epoxy silica sol-gel functionalized polycarbonate-polydimethylsiloxane hybrid microchip Aptasensors for Detection of Avian Influenza Virus H5N1 Rapid detection of avian influenza virus H5N1 in chicken tracheal samples using an impedance aptasensor with gold nanoparticles for signal amplification Aptamer-based 'point-of-care testing Specific Recognition of Human Influenza Virus with PEDOT Bearing Sialic Acid-Terminated Trisaccharides Silver nanoparticles coated graphene electrochemical sensor for the ultrasensitive analysis of avian influenza virus H7 A nanohybrid of platinum nanoparticles-porous ZnO-hemin with electrocatalytic activity to construct an amplified immunosensor for detection of influenza LabVIEW-based impedance biosensing system for detection of avian influenza virus A multi-virus detectable microfluidic electrochemical immunosensor for simultaneous detection of H1N1, H5N1, and H7N9 virus using ZnO nanorods for sensitivity enhancement Label-free electrochemical detection of neuraminidase activity: A facile whole blood diagnostic probe for infectious diseases Ultrasensitive detection of influenza viruses with a glycan-based impedimetric biosensor Influenza A Virus-Host Protein Interactions Control Viral Pathogenesis Immunomodulatory Nonstructural Proteins of Influenza A Viruses Identification of Novel Influenza A Virus Proteins Translated from PA mRNA PA-X is a virulence factor in avian H9N2 influenza virus Direct electrochemical detection of PB1-F2 protein of influenza A virus in infected cells Extrinsic surface-enhanced Raman scattering detection of influenza A virus enhanced by two-dimensional gold@silver core-shell nanoparticle arrays Surface-enhanced Raman scattering based lateral flow immunochromatographic assay for sensitive influenza detection Fluorescent Neuraminidase Assay Based on Supramolecular Dye Capture After Enzymatic Cleavage A promising magnetic SERS immunosensor for sensitive detection of avian influenza virus Early Diagnosis of Influenza Virus A Using Surface-enhanced Raman Scattering-based Lateral Flow Assay Rapid detection of avian influenza A virus by immunochromatographic test using a novel fluorescent dye Enhanced catalytic activity of gold nanoparticle-carbon nanotube hybrids for influenza virus detection Detection of influenza virus using peroxidase-mimic of gold nanoparticles Upconversion luminescence resonance energy transfer (LRET)-based biosensor for rapid and ultrasensitive detection of avian influenza virus H7 subtype Detection and differentiation of influenza viruses with glycan-functionalized gold nanoparticles Neuraminidase Resistant Sialosides for the Detection of Influenza Viruses keywords: acid; amplification; analysis; antibodies; assay; authors; detection; diagnosis; gold; influenza; influenza virus; methods; pcr; rapid; results; sensitivity; sensor; surface; tests; time; virus; viruses cache: cord-323987-gh1m05gi.txt plain text: cord-323987-gh1m05gi.txt item: #243 of 303 id: cord-324001-m7ys95z7 author: Kobinger, Gary P. title: Assessment of the Efficacy of Commercially Available and Candidate Vaccines against a Pandemic H1N1 2009 Virus date: 2010-04-01 words: 3590 flesch: 33 summary: FluSure or pH1N1inact did not generate detectable HAI antibody titers against the seasonal H1N1 strain A/Brisbane/59/2007 included in conventional seasonal influenza vaccines, such as Fluviral or FluMist. H5N1 virus challenge in mice and ferrets Antibody-mediated growth of influenza A NWS virus in macrophagelike cell line P388D1 Infection enhancement of influenza A NWS virus in primary murine macrophages by anti-hemagglutinin monoclonal antibody Subtype cross-reactive, infectionenhancing antibody responses to influenza A viruses The immune response and maternal antibody interference to a heterologous H1N1 swine influenza virus infection following vaccination Immunosuppression during acute infection with foot-and-mouth disease virus in swine is mediated by IL-10 Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs keywords: animals; day; flumist; h1n1; influenza; response; vaccine; virus cache: cord-324001-m7ys95z7.txt plain text: cord-324001-m7ys95z7.txt item: #244 of 303 id: cord-324007-hapzf0fl author: McGeer, Allison J. title: Diagnostic Testing or Empirical Therapy for Patients Hospitalized with Suspected Influenza: What to Do? date: 2009-01-01 words: 2895 flesch: 31 summary: [16] , who demonstrated that hospitalized patients receiving treatment with rimantadine and zanamivir shed influenza virus for several days after hospital admission. Such a policy will have a low risk of adverse events and a low risk of increasing selective pressure for the development of resistant strains of influenza virus. keywords: hospital; influenza; oseltamivir; patients; therapy; treatment cache: cord-324007-hapzf0fl.txt plain text: cord-324007-hapzf0fl.txt item: #245 of 303 id: cord-324181-nyrpg3ud author: Baker, Jeffrey title: Baloxavir Marboxil Single-dose Treatment in Influenza-infected Children: A Randomized, Double-blind, Active Controlled Phase 3 Safety and Efficacy Trial (miniSTONE-2) date: 2020-05-19 words: 4257 flesch: 40 summary: Estimates of global seasonal influenza-associated respiratory mortality: a modelling study Risk factors of influenza transmission in households Vaccines for seasonal and pandemic influenza Strategies to achieve the healthy people 2020 annual influenza vaccine coverage goal for health-care personnel: recommendations from The National Vaccine Advisory Committee Influenza vaccines: challenges and solutions New vaccines against influenza virus The evolving history of influenza viruses and influenza vaccines Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern The origin and global emergence of adamantane resistant A/H3N2 influenza viruses Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently suppresses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models XOFLUZA (baloxavir marboxil) prescribing information In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit Baloxavir marboxil for uncomplicated influenza in adults and adolescents Phase 3 trial of baloxavir marboxil in high-risk influenza patients (CAPSTONE-2 study) TAMIFLU (oseltamivir) prescribing information Canadian acute respiratory illness and flu scale (CARIFS): development of a valid measure for childhood respiratory infections Detection of nonhemagglutinating influenza a(h3) viruses by enzyme-linked immunosorbent assay in quantitative influenza virus culture Baloxavir marboxil in Japanese pediatric patients with influenza: safety and clinical and virologic outcomes Multicenter evaluation of BioFire FilmArray respiratory panel 2 for detection of viruses and bacteria in nasopharyngeal swab samples Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil Presented at OPTIONS X for the Control of Influenza Presented at OPTIONS X for the Control of Influenza Does respiratory virus coinfection increases the clinical severity of acute respiratory infection among children infected with respiratory syncytial virus? Secondary virologic endpoints included time to cessation of viral shedding by virus titer and change from baseline in influenza virus titer. keywords: aes; baloxavir; children; groups; influenza; oseltamivir; study; treatment; virus cache: cord-324181-nyrpg3ud.txt plain text: cord-324181-nyrpg3ud.txt item: #246 of 303 id: cord-324301-bzrh2fni author: Zambon, Maria title: Influenza, respiratory syncytial virus and SARS date: 2005-05-01 words: 2979 flesch: 39 summary: The Japanese experience with vaccinating school children against influenza Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir Age related differences in humoral immune response to respiratory syncytial virus infection in adults Confirmation of a novel corona virus as the primary cause of severe acute respiratory syndrome Zoonotic infections involving several different subtypes of influenza have occurred in the last few years, indicating the pandemic potential of influenza viruses circulating in domestic poultry. keywords: disease; humans; illness; infection; influenza; rsv; virus cache: cord-324301-bzrh2fni.txt plain text: cord-324301-bzrh2fni.txt item: #247 of 303 id: cord-325141-x3txhjkr author: Grech, Victor title: Vaccine hesitancy among Maltese Healthcare workers toward influenza and novel COVID-19 vaccination date: 2020-10-01 words: 3682 flesch: 44 summary: Discussion The increased uptake of influenza vaccine is probably due to increased awareness of respiratory viral illness. The increased uptake of influenza vaccine is probably due to increased awareness of respiratory viral illness. keywords: covid-19; healthcare; hesitancy; influenza; uptake; vaccination; vaccine; workers cache: cord-325141-x3txhjkr.txt plain text: cord-325141-x3txhjkr.txt item: #248 of 303 id: cord-325197-j1uo8qmf author: Crimi, Ettore title: Epigenetic susceptibility to severe respiratory viral infections: pathogenic and therapeutic implications: a narrative review date: 2020-08-20 words: 6080 flesch: 21 summary: The architecture of SARS-CoV-2 transcriptome Control of viral infections by epigenetic-targeted therapy Epigenetic mechanisms of importance for drug treatment Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-kB signaling pathway. key: cord-325197-j1uo8qmf authors: Crimi, Ettore; Benincasa, Giuditta; Figueroa-Marrero, Neisaliz; Galdiero, Massimiliano; Napoli, Claudio title: Epigenetic susceptibility to severe respiratory viral infections: pathogenic and therapeutic implications: a narrative review date: 2020-08-20 journal: keywords: coronavirus; cov-2; covid-19; disease; host; human; immune; infections; influenza; mechanisms; patients; response; sars; virus; viruses cache: cord-325197-j1uo8qmf.txt plain text: cord-325197-j1uo8qmf.txt item: #249 of 303 id: cord-325325-xw7627x9 author: Skeik, Nedaa title: Influenza viruses and the evolution of avian influenza virus H5N1 date: 2007-10-02 words: 4082 flesch: 45 summary: Although the risk of transmission from person Influenza viruses and the evolution of avian influenza virus H5N1 to person appears low, quarantining of close contacts to patients for a week after last exposure and monitoring for symptoms may help to reduce transmission rates. Despite the high level of technology and ongoing research, at the present time there is no highly effective vaccine against avian influenza H5N1 virus that can be manufactured commercially on a large scale for use at low doses. keywords: avian; h5n1; human; infection; influenza; pandemic; vaccine; virus; viruses cache: cord-325325-xw7627x9.txt plain text: cord-325325-xw7627x9.txt item: #250 of 303 id: cord-326160-mf0vh6iu author: de Wit, Emmie title: Influenza Virus A/Anhui/1/2013 (H7N9) Replicates Efficiently in the Upper and Lower Respiratory Tracts of Cynomolgus Macaques date: 2014-08-12 words: 6448 flesch: 33 summary: World Health Organization Clinical findings in 111 cases of influenza A (H7N9) virus infection Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus Past, present, and possible future human infection with influenza virus A subtype H7 Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China The genesis and source of the H7N9 influenza viruses causing human infections in China Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice Limited airborne transmission of H7N9 influenza In agreement with the observed abundant attachment of the H7N9 influenza A virus to the human upper and lower respiratory tracts (41) , and the replication of the H7N9 virus in ex vivo cultures of the human upper as well as lower respiratory tract (42) , H7N9 virus replicated well in the upper and lower respiratory tracts of cynomolgus macaques, as indicated by virus titers in nasal turbinates, oronasopharynges, tracheas, bronchi, and lung tissue samples, reflecting the previously described receptor distribution of influenza virus H7N9 in the macaque respiratory tract (15) . keywords: anhui/1/2013; animals; cells; cynomolgus; dpi; fig; h7n9; human; infection; influenza; influenza virus; lesions; lung; macaques; virus cache: cord-326160-mf0vh6iu.txt plain text: cord-326160-mf0vh6iu.txt item: #251 of 303 id: cord-326177-zzsaf3bl author: Khatri, Mahesh title: Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model date: 2018-01-29 words: 6679 flesch: 44 summary: We examined whether MSC-EVs had the ability to enter cells using pig lung epithelial cells (MK1-OSU; LECs). biology and potential therapeutic value Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study Swine influenza H1N1 virus induces acute inflammatory immune responses in pig lungs: a potential animal model for human H1N1 influenza virus Human mesenchymal stromal cells reduce influenza A H5N1-associated acute lung injury in vitro and in vivo Mesenchymal stromal (stem) cell therapy fails to improve outcomes in experimental severe influenza Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy Mesenchymal stromal cell treatment prevents H9N2 avian influenza virus-induced acute lung injury in mice Isolation and characterization of chicken lung mesenchymal stromal cells and their susceptibility to avian influenza virus Influenza virus infects bone marrow mesenchymal stromal cells in vitro: implications for bone marrow transplantation Tropism of avian influenza A (H5N1) virus to mesenchymal stem cells and CD34+ hematopoietic stem cells Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery Proteomic analysis of microvesicles derived from human mesenchymal stem cells Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice Role of stem cell-derived microvesicles in the paracrine action of stem cells Cellular phenotype switching and microvesicles Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice keywords: anti; cells; evs; human; influenza; lung; mesenchymal; model; msc; mscs; pigs; stem; swiv; virus cache: cord-326177-zzsaf3bl.txt plain text: cord-326177-zzsaf3bl.txt item: #252 of 303 id: cord-326614-cik3ino6 author: Corder, Brigette N. title: A Decade in Review: A Systematic Review of Universal Influenza Vaccines in Clinical Trials during the 2010 Decade date: 2020-10-20 words: 7556 flesch: 40 summary: Influenza Other Respir Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices-United States Deaths averted by influenza vaccination in the U.S. during the seasons 2005/06 through 2013/14 Seasonal Flu Vaccine Effectiveness Studies Immune History and Influenza Vaccine Effectiveness A Study to Assess the Safety and Immunogenicity of a New Influenza Vaccine Candidate MVA-NP+M1 in Healthy Adults Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1 Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses A T cell-inducing influenza vaccine for the elderly: Safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans A Study to Assess the Safety and Efficacy of a New Influenza Candidate Vaccine MVA-NP+M1 In Healthy Adults University of Oxford. Vaccine Safety and Immunogenicity Of A Recombinant H5N1 Vaccine In Adults Safety and immunogenicity of a plant-produced recombinant hemagglutinin-based influenza vaccine (HAI-05) derived from A/Indonesia/05/2005 (H5N1) influenza virus: A phase 1 randomized, double-blind, placebo-controlled, dose-escalation study in healthy adults Study of Single Dose GHB16L2 Trivalent Influenza Vaccine in Healthy Adults Muster, T. Phase I/II trial of a replication-deficient trivalent influenza virus vaccine lacking NS1 Protein Sciences Corporation. keywords: immune; immunogenicity; influenza; np+m1; participants; phase; response; safety; study; trials; vaccination; vaccine; virus cache: cord-326614-cik3ino6.txt plain text: cord-326614-cik3ino6.txt item: #253 of 303 id: cord-326960-9phlylce author: Felberbaum, Rachael S. title: The baculovirus expression vector system: A commercial manufacturing platform for viral vaccines and gene therapy vectors date: 2015-03-20 words: 7296 flesch: 38 summary: Recombinant protein vaccines produced in insect cells Vaccines for viral and parasitic diseases produced with baculovirus vectors Commercial production in insect cells. The advantages of recombinant BEVS vaccines for pandemic influenza are especially important. keywords: baculovirus; bevs; cells; expression; gene; influenza; insect; manufacturing; platform; production; products; protein; recombinant; therapy; vaccine; virus cache: cord-326960-9phlylce.txt plain text: cord-326960-9phlylce.txt item: #254 of 303 id: cord-327180-yw8rzrb7 author: Prateepko, Tapanan title: Patterns of perception toward influenza pandemic among the front-line responsible health personnel in southern Thailand: a Q methodology approach date: 2009-05-28 words: 3760 flesch: 48 summary: As health personnel are key persons for influenza pandemic preparedness and con-trol, it is hoped that understanding their patterns of perception will allow control programs to properly improve the training. Health personnel designated by each facility to be responsible for influenza pandemic preparedness were identified. keywords: efficacy; factor; health; influenza; pandemic; personnel; self; study cache: cord-327180-yw8rzrb7.txt plain text: cord-327180-yw8rzrb7.txt item: #255 of 303 id: cord-327516-i25whxt2 author: Horby, Peter title: Improving preparedness for the next flu pandemic date: 2018-07-25 words: 2064 flesch: 36 summary: G iven its potential to cause an acute global health crisis with many millions of deaths, pandemic influenza can rightly be considered the greatest single threat to global health security. As we have seen being recently developed for other high-threat pathogens, such as the viral haemorrhagic fevers and Middle East respiratory syndrome coronavirus, what is needed is a blueprint for action against pandemic influenza that is comprehensive, detailed, endorsed, funded and monitored. keywords: data; health; influenza; pandemic; viruses cache: cord-327516-i25whxt2.txt plain text: cord-327516-i25whxt2.txt item: #256 of 303 id: cord-327819-7p05jk1h author: Trampuz, Andrej title: Avian Influenza: A New Pandemic Threat? date: 2004-04-30 words: 5105 flesch: 43 summary: Despite the widespread infection of avian influenza viruses among poultry in Asia, reported infection in humans has been rare to date. Avian influenza viruses do not replicate efficiently in humans, which suggested initially that direct avian-to-human transmission would not occur. keywords: avian; birds; disease; h5n1; human; infection; influenza; pandemic; poultry; virus; viruses cache: cord-327819-7p05jk1h.txt plain text: cord-327819-7p05jk1h.txt item: #257 of 303 id: cord-328290-kbysppgb author: Beckmann, Christiane title: Diagnostic performance of near-patient testing for influenza date: 2015-03-31 words: 1991 flesch: 47 summary: Conclusion: Simple sample processing and a TAT of 15 min render isothermal NAT Alere TM Influenza A&B suitable for sequential near-patient testing, but the TAT advantage is lost when testing of larger series. Isothermal NAT was 10-100-fold more sensitive compared to DAD for influenza virus culture supernatants with a lower limit of detection of 5000-50,000 copies/mL. The average turn-around time (TAT) of isothermal NAT and DADs was 15 min, but increased to 110 min for Alere TM Influenza A&B, 30 min for BinaxNOW ® Influenza A&B, and 45 min for Sofia ® Influenza A + B, when analyzing batches of 6 samples. keywords: a&b; influenza; nat cache: cord-328290-kbysppgb.txt plain text: cord-328290-kbysppgb.txt item: #258 of 303 id: cord-328525-80xk3gln author: Baier, Claas title: Influenza and respiratory syncytial virus screening for the detection of asymptomatically infected patients in hematology and oncology date: 2018-09-24 words: 3391 flesch: 35 summary: The 6 patients showed an increase in viral load during their clinical course and were therefore presumably detected during the incubation period. 13 of the 23 (57%) asymptomatic patients were in twoand four-bed rooms at the time the screening test was reported positive (4 positive for RSV, 9 positive for influenza virus). Competing interests Respiratory syncytial virus -a comprehensive review Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe Community acquired respiratory virus infections in cancer patients -Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology Respiratory viruses in transplant recipients: more than just a cold. keywords: control; infection; influenza; patients; rsv; screening; virus cache: cord-328525-80xk3gln.txt plain text: cord-328525-80xk3gln.txt item: #259 of 303 id: cord-328979-xfze12ah author: Monto, Arnold S title: Data resource profile: Household Influenza Vaccine Evaluation (HIVE) Study date: 2019-04-30 words: 3879 flesch: 37 summary: The testnegative design: validity, accuracy and precision of vaccine efficacy estimates compared to the gold standard of randomised placebocontrolled clinical trials The case testnegative design for studies of the effectiveness of influenza vaccine The test-negative design for estimating influenza vaccine effectiveness Theoretical basis of the test-negative study design for assessment of influenza vaccine effectiveness An optimized enzymelinked lectin assay to measure influenza A virus neuraminidase inhibition antibody titers in human sera Influenza vaccine effectiveness in the community and the household Influenza vaccine effectiveness in households with children during the 2012-2013 season: assessments of prior vaccination and serologic susceptibility Substantial influenza vaccine effectiveness in households with children during the 2013-2014 influenza season, when 2009 pandemic influenza A(H1N1) virus predominated The household influenza vaccine effectiveness study: lack of antibody response and protection following receipt of 2014-2015 influenza vaccine Effectiveness of seasonal influenza vaccines in the United States during a season with circulation of all three vaccine strains Influenza vaccine effectiveness in the 2011-2012 season: protection against each circulating virus and the effect of prior vaccination on estimates Influenza vaccine effectiveness in the United States during 2012-2013: variable protection by age and virus type Influenza vaccine effectiveness against 2009 pandemic influenza A(H1N1) virus differed by vaccine type during 2013-2014 in the United States influenza vaccine effectiveness in the United States by vaccine type Influenza vaccine effectiveness in the United States during the 2015-2016 season The doctrine of original antigenic sin: separating good from evil Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital Efficacy of repeated annual immunization with inactivated influenza virus vaccines over a five year period Variable efficacy of repeated annual influenza vaccination Antibodies against the current influenza A(H1N1) vaccine strain do not protect some individuals from infection with contemporary circulating influenza A(H1N1) virus strains Influenza transmission in a cohort of households with children Stochastic processes constrain the within and between host evolution of influenza virus Application of an individual-based transmission hazard model for estimation of influenza vaccine effectiveness in a household cohort Co-colonization by Streptococcus pneumoniae and Staphylococcus aureus in the throat during acute respiratory illnesses Frequency of acute respiratory illnesses and circulation of respiratory viruses in households with children over 3 surveillance seasons The original aims of this study were to estimate influenza vaccine effectiveness annually and to compare those estimates with those from TND studies conducted in outpatient clinics during the same seasons. keywords: effectiveness; illness; influenza; season; specimens; study; vaccination; vaccine; viruses cache: cord-328979-xfze12ah.txt plain text: cord-328979-xfze12ah.txt item: #260 of 303 id: cord-329653-5nkrrqqw author: Patrick, Jennifer R. title: Influenza: Critique of the contemporary challenges for pandemic planning, prevention, control, and treatment in emergency health services date: 2011-04-08 words: 4483 flesch: 37 summary: Pandemic influenza: a summary of health's operational plan Special counter disaster plan: human pandemic influenza Hospital response to pandemic influenza, part 1: Emergency Department response NSW Human Influenza Pandemic Sub Plan Queensland Department of the Premier and Cabinet What is pandemic influenza, and what is the difference between it and seasonal influenza keywords: control; disease; h1n1; health; healthcare; infection; influenza; pandemic; prevention; public; vaccination; workers cache: cord-329653-5nkrrqqw.txt plain text: cord-329653-5nkrrqqw.txt item: #261 of 303 id: cord-330512-nu8q72l9 author: Iskander, John title: Pandemic Influenza Planning, United States, 1978–2008 date: 2013-06-17 words: 4157 flesch: 34 summary: On February 25, 1999, and July 13, 2000, CDC presented satellite videoconferences on influenza pandemic preparedness for states and local areas, which were viewed by >7,000 and ≈6,000 participants, respectively. Pandemic influenza preparedness and response: a WHO guidance document US Department of Health and Human Services. keywords: health; influenza; national; pandemic; planning; preparedness; public; response; state; virus cache: cord-330512-nu8q72l9.txt plain text: cord-330512-nu8q72l9.txt item: #262 of 303 id: cord-331148-40gvay7i author: Hsieh, Yu-Chia title: Clinical characteristics of patients with laboratory-confirmed influenza A(H1N1)pdm09 during the 2013/2014 and 2015/2016 clade 6B/6B.1/6B.2-predominant outbreaks date: 2018-10-23 words: 3200 flesch: 37 summary: A confirmed case involved a patient who had acute influenza-like illness (temperature ≥ 38 °C with either cough or sore throat) and nasopharyngeal/throat or bronchoalveolar lavage samples harboring influenza A(H1N1)pdm09 virus as detected using real-time (RT) reverse-transcription polymerase chain reaction (PCR) assay or via viral culture 11, 28 . Patients who had acute influenza-like illness (temperature ≥ 38 °C with either cough or sore throat) and had influenza A(H1N1)pdm09 virus as detected using RT-PCR assay or via viral culture using respiratory specimens were included in the study. keywords: a(h1n1)pdm09; analysis; complications; influenza; season; study; taiwan; virus; years cache: cord-331148-40gvay7i.txt plain text: cord-331148-40gvay7i.txt item: #263 of 303 id: cord-331244-zaguyxm5 author: Stephenson, Iain title: Confronting the avian influenza threat: vaccine development for a potential pandemic date: 2004-07-30 words: 8206 flesch: 29 summary: Current facilities may not be suitable for rapid bulk manufacture of avian influenza virus vaccines in response to a world threat. A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory respiratory distress syndrome Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands Influenza A (H9N2) in Hong Kong Special Administrative Region of China Avian influenza H5N1 infection in humans: urgent need to eliminate the animal reservoir-update 5 Cases of influenza A (H5N1)-Thailand Avian influenza virus A (H10N7) circulating among humans in Egypt An update on avian influenza in Hong Kong in 2002 H5N1 influenza viruses isolated from geese in Southeastern China: evidence for genetic reassortment and interspecies transmission to ducks Discovery of man infected by avian influenza virus Seroprevalence of antibody to H9N2 viruses in poultry workers of Hong Kong Molecular characterization of H9N2 influenza viruses: were they the donors of the internal genes of H5N1 viruses in Hong Kong Influenza A viruses: relationship between H9N2 relationship between H9N2 and H5N1 human isolates Emergence and control of zoonotic ortho-and paramyxovirus diseases Cocirculation of avian H9N2 and human H3N2 viruses in pigs in southern China Seropidemiological evidence of avian H4, H5 and H9 influenza viruses transmission to pigs in south eastern China Characterisation of a human H9N2 influenza virus isolated in Hong Kong Molecular evolution of H6 influenza viruses from poultry in south eastern China: prevalence of H6N1 influenza viruses possessing seven A/HongKong/156/97 H5N1-like genes in poultry Transmission of Eurasian avian H2 influenza virus to shorebirds in North America Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the haemagglutinin polypeptide Proteolytic cleavage of influenza virus haemagglutinins: primary structure of the connecting peptide between HA1 and HA2 determines proteolytic cleavability and pathogenicity of avian influenza viruses Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses A novel mechanism for the acquisition of virulence by a human influenza A virus A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans Molecular correlates of influenza A H5N1 virus pathogenesis Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong Pathogenesis of avian influenza A H5N1 viruses in ferrets Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses Pathogenicity and antigenicity of a new influenza A (H5N1) virus isolated from duck meat Induction of proinflammatory cytokines in human macrophages by influenza A H5N1 viruses: a mechanism for the unusual severity of human disease? Lethal H5N1 influenza viruses escape host anti-viral cytokine responses Origin and evolution of the 1918 Spanish influenza virus heamagglutinin gene Characterisation of the 1918 Spanish influenza virus neuraminidase gene Vaccine production Antigenic drift and efficacy of influenza virus vaccines Efficacy/clinical effectiveness of inactivated influenza virus vaccines in adults Determinants of immunity to influenza infection in man Correlation between rate of infection and pre-existing titer of serum antibody as determined by single radial haemolysis during an epidemic of influenza A/Victoria/3/75 Note for guidance on harmonisation of requirements for influenza vaccines, CPMP/BWP/214/96. keywords: antibody; avian; h5n1; h9n2; haemagglutinin; hong; human; infection; influenza; pandemic; responses; strains; vaccine; viruses cache: cord-331244-zaguyxm5.txt plain text: cord-331244-zaguyxm5.txt item: #264 of 303 id: cord-331714-2qj2rrgd author: Lvov, Dimitry Konstantinovich title: Single-Stranded RNA Viruses date: 2015-05-29 words: 64305 flesch: 46 summary: Influenza virus A/Anas acuta/Primorie/730/76(H3N2) isolated from wild ducks in the Maritime Territory Isolation of influenza strains identical to influenza virus A/Anglia/42/72 from semisynanthropic bird species in Rovno Province, the Ukrainian SSR Human and avian viruses of the Hong Kong series Isolation of an influenza virus from a tree sparrow and the infection rate of the virus in wild birds in the mid-Dnieper Region A new avian influenza virus from feral birds in the USSR: recombination in nature? Isolation of influenza A viruses from wild migratory waterfowl in the north of Europian part of the USSR Incidence of influenza virus infection in black-headed gulls Isolation of influenza virus with the antigenic formula Hav4 Nav2 and Hav5 Transmission of infectious pneumonia and its differentiation from swine influenza Investigations on a virus pneumonia of long duration prevalent in pigs Studies on the HVJ (Hemagglutinating virus of Japan) newly isolated from the swine Multiplication and cytopathogenic effect of the hemagglutinating virus of Japan (HVJ) in swine kidney tissue culture Discussion on virus infections of the upper respiratory tract Resemblance of a strain of swine influenza virus to human A-prime strains Investigation of swine respiratory diseases in Lithuania SSR Bulletin of scientific-technical information. keywords: aedes; africa; analysis; animals; antibodies; antigenic; arboviruses; asia; avian; bats; bhanja virus; birds; borne; bunyaviridae; cases; central; characterization; chikungunya virus; circulation; clinical; common; congo; crimean; days; delta; dengue virus; different; disease; distribution; east; eastern; encephalitis virus; epidemic; eurasia; europe; european; experimental; family; far; fever virus; figure; foci; genome; genus; group; h5n1; hemorrhagic; high; hosts; human; infected; infections; influenza virus; international; isolation; ixodes; krai; moscow; mosquitoes; nairovirus; natural; new; nile virus; northern; patients; protein; rdrp; region; republic; russia; segment; siberia; similarity; southern; species; strains; table; tahyna virus; tbev; territory; ticks; ussr; uukuniemi virus; vectors; vertebrate; virus; virus circulation; virus group; virus infection; virus isolation; virus strains; virus taxonomy; viruses; volga; western; wild; wnv cache: cord-331714-2qj2rrgd.txt plain text: cord-331714-2qj2rrgd.txt item: #265 of 303 id: cord-332485-8tfgl8rp author: Marcorelles, P title: Décès brutal et infection à virus Influenza A chez un enfant de deux ans : étude d’un cas autopsique date: 2002-02-15 words: 906 flesch: 53 summary: Les lésions microscopiques prédominent au niveau pulmonaire et comportent une alvéolite hémorragique dans 98 % des cas, très souvent associée à un infiltrat mononucléé interstitiel et à une congestion ; mais il existe rarement un infiltrat à polynucléaires en dehors des surinfections. Les signes principaux comprennent la somnolence, un syndrome parkinsonnien transitoire et des encéphalites de deux types : aiguës virales ou postvirales apparaissant à distance. keywords: des; virus cache: cord-332485-8tfgl8rp.txt plain text: cord-332485-8tfgl8rp.txt item: #266 of 303 id: cord-332516-eaqpiq1o author: Joseph, Carol title: Bacterial and viral infections associated with influenza date: 2013-08-27 words: 6470 flesch: 30 summary: 1, 2 Morbidity and mortality are recognised to be greater in cases of influenza-associated bacterial infection compared with bacterial pneumonia without influenza infection 3 with all age groups affected by this synergistic process. 40 Transmission studies using animal models show increased incidence and severity of bacterial pneumonia after influenza infection is pneumococcal strain dependent. keywords: bacterial; cases; deaths; disease; h1n1; infection; influenza; pandemic; pneumonia; virus cache: cord-332516-eaqpiq1o.txt plain text: cord-332516-eaqpiq1o.txt item: #267 of 303 id: cord-333527-66dfphxq author: Brown, Lawrence H title: Self-reported anticipated compliance with physician advice to stay home during pandemic (H1N1) 2009: Results from the 2009 Queensland Social Survey date: 2010-03-16 words: 3680 flesch: 40 summary: This study was undertaken during the height of the Australian pandemic (H1N1) 2009 outbreak to measure self-reported willingness to comply with physician recommendations to stay home for seven days, and to compare responses for the current strain of pandemic influenza, avian influenza, seasonal influenza, and the common cold. This study was undertaken during the height of the Australian pandemic (H1N1) 2009 outbreak to measure self-reported willingness to comply with physician recommendations to stay home for seven days, and to compare responses for the current strain of pandemic influenza, avian influenza (H5N1), seasonal influenza, and the common cold. keywords: advice; compliance; health; home; influenza; pandemic; stay cache: cord-333527-66dfphxq.txt plain text: cord-333527-66dfphxq.txt item: #268 of 303 id: cord-333722-ndth5zne author: Liu, Qiang title: The cytokine storm of severe influenza and development of immunomodulatory therapy date: 2015-07-20 words: 5133 flesch: 33 summary: Host response to influenza virus: protection versus immunopathology Into the eye of the cytokine storm Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection A question of selfpreservation: immunopathology in influenza virus infection Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque Structured regulation of inflammation during respiratory viral infection Innate immune responses to influenza A H5N1: friend or foe? Recognition of microorganisms and activation of the immune response A calculated response: control of inflammation by the innate immune system Genetic insights into sepsis: what have we learned and how will it help? 15 Severe cytokine storm, with markedly higher levels of proinflammatory cytokines including interferons (IFNs), tumor necrosis factors (TNFs), interleukins (ILs), and chemokines, has been detected in patients hospitalized with severe influenza infections. keywords: cells; cytokine; h1n1; h5n1; infection; influenza; mice; mortality; response; storm; virus cache: cord-333722-ndth5zne.txt plain text: cord-333722-ndth5zne.txt item: #269 of 303 id: cord-334424-z7ygy25e author: McCaw, James M title: Household transmission of respiratory viruses – assessment of viral, individual and household characteristics in a population study of healthy Australian adults date: 2012-12-11 words: 4794 flesch: 37 summary: The lack of virological assessment of household secondary cases and the broad nature of the question used to establish the secondary case count in each house also contributes to uncertainty with regards to our assignment of temporally associated ILI to within-household transmission. key: cord-334424-z7ygy25e authors: McCaw, James M; Howard, Peter F; Richmond, Peter C; Nissen, Michael; Sloots, Theo; Lambert, Stephen B; Lai, Michael; Greenberg, Michael; Nolan, Terry; McVernon, Jodie title: Household transmission of respiratory viruses – assessment of viral, individual and household characteristics in a population study of healthy Australian adults date: 2012-12-11 journal: BMC Infect Dis DOI: 10.1186/1471-2334-12-345 sha: doc_id: 334424 cord_uid: z7ygy25e BACKGROUND: keywords: case; children; events; household; ili; influenza; participant; study; transmission cache: cord-334424-z7ygy25e.txt plain text: cord-334424-z7ygy25e.txt item: #270 of 303 id: cord-335647-dhcxj7cj author: Vanderlinden, Evelien title: Emerging Antiviral Strategies to Interfere with Influenza Virus Entry date: 2013-06-25 words: 15140 flesch: 36 summary: Binding to N1 enzymes in the context of virus-like particles Mechanismbased covalent neuraminidase inhibitors with broad spectrum influenza antiviral activity A novel small-molecule inhibitor of the avian influenza H5N1 virus determined through computational screening against the neuraminidase T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections Influenza hemagglutinin and neuraminidase membrane glycoproteins A distinct lineage of influenza A virus from bats Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site The influenza virus enigma Assembly of influenza hemagglutinin trimers and its role in intracellular transport Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation Novel insights into proteolytic cleavage of influenza virus hemagglutinin Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases S acylation of the hemagglutinin of influenza viruses: mass spectrometry reveals site-specific attachment of stearic acid to a transmembrane cysteine Evidence for N-glycan shielding of antigenic sites during evolution of human influenza A virus hemagglutinin Glycosylation focuses sequence variation in the influenza The role of nuclear import and export in influenza virus infection Influenza virus assembly and budding Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins Unpacking the incoming influenza virus Dissection of influenza A virus M1 protein: pH-dependent oligomerization of N-terminal domain and dimerization of C-terminal domain Structural changes in Influenza virus at low pH characterized by cryo-electron tomography Influenza virus uncoating in infected cells and effect of rimantadine A small percentage of influenza virus M1 protein contains zinc but zinc does not influence in vitro M1-RNA interaction Antiviral activity of influenza virus M1 zinc finger peptides Architecture of ribonucleoprotein complexes in influenza A virus particles The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA Ultrastructural analysis of the nuclear localization sequences on influenza A ribonucleoprotein complexes An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication Activity of Ingavirin (6-[2-(1H-Imidazol-4-yl)ethylamino]-5-oxohexanoic Acid) against human respiratory viruses in in vivo experiments Nebol'sin VE. keywords: acid; activity; amantadine; antibody; antiviral; binding; cell; channel; entry; fusion; hemagglutinin; human; infection; influenza; influenza virus; inhibitors; membrane; protein; proton; receptor; residues; resistance; virus; virus activity; viruses cache: cord-335647-dhcxj7cj.txt plain text: cord-335647-dhcxj7cj.txt item: #271 of 303 id: cord-335948-qkfxfmxb author: Ampofo, William K. title: Improving influenza vaccine virus selectionReport of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14–16 June 2010 date: 2011-08-08 words: 10007 flesch: 18 summary: key: cord-335948-qkfxfmxb authors: Ampofo, William K.; Baylor, Norman; Cobey, Sarah; Cox, Nancy J.; Daves, Sharon; Edwards, Steven; Ferguson, Neil; Grohmann, Gary; Hay, Alan; Katz, Jacqueline; Kullabutr, Kornnika; Lambert, Linda; Levandowski, Roland; Mishra, A. C.; Monto, Arnold; Siqueira, Marilda; Tashiro, Masato; Waddell, Anthony L.; Wairagkar, Niteen; Wood, John; Zambon, Maria; Zhang, Wenqing title: Improving influenza vaccine virus selectionReport of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14–16 June 2010 date: 2011-08-08 journal: The expanded and enhanced role of the GISRS following the adoption of the International Health Regulations (2005), recognition of the continuing threat posed by avian H5N1 and the aftermath of the 2009 H1N1 pandemic provide an opportune time to critically review the process by which influenza vaccine viruses are selected. keywords: antigenic; data; development; gisrs; global; human; influenza; influenza vaccine; influenza viruses; pandemic; selection; vaccine; vaccine virus; virus selection; viruses cache: cord-335948-qkfxfmxb.txt plain text: cord-335948-qkfxfmxb.txt item: #272 of 303 id: cord-335960-biwnqa3f author: Luke, Anthony title: Prevention of Infectious Diseases in Athletes date: 2007-07-31 words: 6817 flesch: 42 summary: key: cord-335960-biwnqa3f authors: Luke, Anthony; d'Hemecourt, Pierre title: Prevention of Infectious Diseases in Athletes date: 2007-07-31 journal: Clinics in Sports Medicine DOI: 10.1016/j.csm.2007.04.006 sha: doc_id: 335960 cord_uid: biwnqa3f The sports medicine physician may face challenging issues regarding infectious diseases when dealing with teams or highly competitive athletes who have difficulties taking time off to recover. This article reviews preventive strategies for infectious disease in athletes, including immunization recommendations and prophylaxis guidelines, improvements in personal hygiene and prevention of spread of infectious organisms by direct contact, insect-borne disease precautions, and prevention of sexually transmitted diseases. keywords: athletes; contact; disease; immunization; infection; influenza; pertussis; prevention; risk; sports; tick; use; vaccination; vaccine; virus; years cache: cord-335960-biwnqa3f.txt plain text: cord-335960-biwnqa3f.txt item: #273 of 303 id: cord-336168-hvp13ell author: Yazdanbakhsh, Maria title: Influenza in Africa date: 2009-12-15 words: 1706 flesch: 39 summary: To this end proper surveillance systems should be set up in already existing and well-established clinical research centers to understand the epidemiology of influenza in Africa, which in turn may help the processes of decision making regarding influenza vaccination on the continent, which may have a high impact on health in Africa. Seasonality of influenza in Brazil: a traveling wave from the Amazon to the subtropics Influenza-associated hospitalization in a subtropical city Seasonality of influenza in the tropics: a distinct pattern in northeastern Brazil Global patterns in seasonal activity of influenza A/H3N2, A/H1N1, and B from 1997 to 2005: viral coexistence and latitudinal gradients The global circulation of seasonal influenza A (H3N2) viruses Etiology of serious infections in young Gambian infants Epidemiological and virological influenza survey in Dakar, Senegal: 1996-1998 Influenza virus strains in Nairobi, Kenya Results of two-year surveillance of flu in Abidjan Cellular and humoral responses to influenza in Gabonese children living in rural and semi-urban areas Influenza A (H1N1) -update 20 Interim report on pandemic H1N1 influenza virus infections in South Africa Introduction and transmission of 2009 pandemic influenza A (H1N1) Virus-Kenya Mortality rates from malaria in children under 5 fall sharply in 10 countries The limits and intensity of Plasmodium falciparum transmission: implications for malaria control and elimination worldwide Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial Community acquired pneumonia in children in Lambarene, Gabon Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with fever A variety of respiratory viruses found in symptomatic travellers returning from countries with ongoing spread of the new influenza A(H1N1)v virus strain Immune regulation by helminth parasites: cellular and molecular mechanisms Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection A phase II, randomized study on an investigational DTPw-HBV/Hib-MenAC conjugate vaccine administered to infants in Northern Ghana The epidemiology of influenza in a tropical (Gambian) environment Weaker Th1 and pro-inflammatory cytokine responses to influenza virus antigens were seen in vaccinated rural children compared to the semi-urban vacinees. keywords: africa; children; influenza; malaria; virus cache: cord-336168-hvp13ell.txt plain text: cord-336168-hvp13ell.txt item: #274 of 303 id: cord-336465-qrok21qo author: Perez, Luis E. title: Evaluation of the specificity and sensitivity of a potential rapid influenza screening system date: 2013-01-31 words: 3472 flesch: 32 summary: Thus, development of a rapid, cost-effective, and accurate screening system for influenza virus available to the general population and/or local physicians and medical treatment facilities would likely reduce the misuse of antibiotic therapy for treatment of influenza infections. The lack of an affordable, near point-of-care, sensitive, and specific screening system for influenza virus created a void that was addressed by Lucigen Corp. (Middleton, WI, USA) by designing a first-generation system to test the feasibility of a nucleic acid lateral flow system for testing both influenza A and B. The PyroScript® influenza A and B reagents require the use of a nucleic acid lateral flow (NALF) device for the detection of influenza A or B-amplified RNA molecules. keywords: assay; influenza; nucleic; pyroscript; rvp; samples; virus cache: cord-336465-qrok21qo.txt plain text: cord-336465-qrok21qo.txt item: #275 of 303 id: cord-336493-ggo9wsrm author: Huang, Stephen S. H. title: Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure date: 2013-04-23 words: 6449 flesch: 37 summary: To date, little is known about the immune and clinical response to H1N1 influenza viruses of the past 100 years and how the H1N1 subtype genetic drift and shift affected immune crossreactivity. A H1N1 infection in England: a cross-sectional serological study In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses Sequential Seasonal H1N1 Influenza Virus Infections Protect Ferrets Against Novel 2009 H1N1 Influenza The effect of priming with H1N1 influenza viruses of variable antigenic distance on challenge with 2009 pandemic H1N1 virus Failure of influenza vaccine to prevent two successive outbreaks of influenza A H1N1 in a school community The ferret as a model organism to study influenza A virus infection Cloning, expression and characterization of ferret CXCL10 Understanding original antigenic sin in influenza with a dynamical system Assessment of signs of influenza illness in the ferret model MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees Clustal W and Clustal X version 2.0 keywords: analysis; antigenic; cross; evolution; ferrets; h1n1; infection; influenza; pandemic; strains; virus; viruses cache: cord-336493-ggo9wsrm.txt plain text: cord-336493-ggo9wsrm.txt item: #276 of 303 id: cord-336915-dbu93ufh author: Aloizos, Stavros title: H1N1 Influenza Viral Infection in a Postpartum Young Woman Causes Respiratory Failure: What the Care Providers Ought to Know? date: 2012-10-23 words: 1950 flesch: 40 summary: We report the case of a young postpartum caucasian woman, with no preexisting illness, presenting with respiratory manifestations of H1N1 influenza virus infection two days after Caesarean delivery of a healthy newborn. Treatment of severe influenza A (H1N1) is primarily supportive, although a role for antiviral medications exists. keywords: h1n1; infection; influenza; pregnancy; risk cache: cord-336915-dbu93ufh.txt plain text: cord-336915-dbu93ufh.txt item: #277 of 303 id: cord-337721-who0xdyz author: Faggion, Heloisa Zimmerman title: Influenza Sentinel Surveillance and Severe Acute Respiratory Infection in a Reference Hospital in Southern Brazil date: 2019-12-20 words: 2371 flesch: 38 summary: The clinical manifestations of influenza virus infection include fever, headache, myalgia, cough, and sore throat. However, 10.4% (n=46) were influenza virus (80% FluA; 20% FluB). keywords: cases; infections; influenza; patients; study; virus cache: cord-337721-who0xdyz.txt plain text: cord-337721-who0xdyz.txt item: #278 of 303 id: cord-338674-tnnd1s57 author: Yin, J Kevin title: Pilot study of influenza vaccine effectiveness in urban Australian children attending childcare date: 2011-06-10 words: 3043 flesch: 44 summary: Sixty‐three children received influenza vaccine and 88 participated as controls. 3 Evidence for the effectiveness of influenza vaccine in children aged less than 24 months is limited and high quality, appropriately powered, randomised controlled trials are needed. keywords: childcare; children; ili; influenza; months; study; swabs; vaccine cache: cord-338674-tnnd1s57.txt plain text: cord-338674-tnnd1s57.txt item: #279 of 303 id: cord-339230-cc7gcy5b author: Smith, Amber M. title: Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis date: 2014-07-16 words: 10415 flesch: 21 summary: This led to the first animal studies confirming that bacteria contribute to disease during influenza virus infections by using filtered and unfiltered human sputum (Wherry and Butterfield 1921) . Numerous alterations of the respiratory epithelium and host immune responses occur during influenza virus infection that predisposes a host to coinfection with bacterial pathogens. keywords: bacteria; cells; coinfections; disease; et al; host; infection; influenza; lung; mccullers; mice; models; pathogens; pb1; pneumococcal; pneumonia; responses; streptococcus; virus; viruses cache: cord-339230-cc7gcy5b.txt plain text: cord-339230-cc7gcy5b.txt item: #280 of 303 id: cord-339638-yrxoj1hl author: Goldman, Ran D. title: Willingness to Vaccinate Children against Influenza after the COVID-19 Pandemic date: 2020-08-07 words: 3507 flesch: 37 summary: Public Health officials will need to ensure clear messaging on the safety of influenza vaccines next year, especially in face of COVID-19, to influence parental decision making to convert into vaccinating children. Caregivers were more likely to change from non-vaccination last year to vaccination in the coming year when they had education more than high-school, they took the vaccine themselves or planning to get vaccinated themselves next year, had a child with an up-to-date vaccination schedule excluding influenza vaccines or were worried their child may have COVID-19 or influenza during the visit in the ED. keywords: caregivers; children; covid-19; influenza; vaccination; vaccine; year cache: cord-339638-yrxoj1hl.txt plain text: cord-339638-yrxoj1hl.txt item: #281 of 303 id: cord-340611-7ftnttm0 author: Gensheimer, K. F title: Challenges and opportunities in pandemic influenza planning: lessons learned from recent infectious disease preparedness and response efforts date: 2004-06-30 words: 1833 flesch: 30 summary: key: cord-340611-7ftnttm0 authors: Gensheimer, K. F title: Challenges and opportunities in pandemic influenza planning: lessons learned from recent infectious disease preparedness and response efforts date: 2004-06-30 journal: Crosby's [1] book, 'America's Forgotten Pandemic: Influenza 1918' notes that more Americans died of pandemic influenza than of war-related causalities throughout the entire history of this nation. keywords: health; influenza; pandemic; public; response cache: cord-340611-7ftnttm0.txt plain text: cord-340611-7ftnttm0.txt item: #282 of 303 id: cord-340678-2e2s1gof author: Skowronski, Danuta M title: Influenza vaccine does not increase the risk of coronavirus or other non-influenza respiratory viruses: retrospective analysis from Canada, 2010-11 to 2016-17 date: 2020-05-22 words: 1649 flesch: 38 summary: In the context of effective influenza vaccine, influenza cases would have lower likelihood of vaccination; as such, their inclusion would systematically reduce the proportion vaccinated in the control group and thereby inflate ORs comparing vaccine exposure between NIRV cases and controls. Here, we use historic datasets of the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) to assess the association between influenza vaccine and NIRV risk, notably seasonal coronaviruses. keywords: influenza; nirv; vaccine cache: cord-340678-2e2s1gof.txt plain text: cord-340678-2e2s1gof.txt item: #283 of 303 id: cord-341364-dle938bt author: Thompson, Catherine title: Influenza, respiratory syncytial virus and SARS date: 2009-11-26 words: 3373 flesch: 39 summary: Emergence of a novel swine-origin influenza A (H1N1) virus in humans H1N1 2009 influenza virus infection during pregnancy in the USA The Japanese experience with vaccinating school children against influenza Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir The potential impact of neuraminidase inhibitor resistant influenza Age related differences in humoral immune response to respiratory syncytial virus infection in adults Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome However, Bird-to-human transmission Place the high variability of influenza virus means that antibodies to one strain confer only limited protection against drift variants. keywords: disease; humans; infection; influenza; neuraminidase; pandemic; rsv; virus cache: cord-341364-dle938bt.txt plain text: cord-341364-dle938bt.txt item: #284 of 303 id: cord-341626-04svm6le author: Assink, M.D.M. title: Excess drug prescriptions during influenza and RSV seasons in the Netherlands: Potential implications for extended influenza vaccination date: 2009-02-11 words: 5667 flesch: 40 summary: Infant and children seasonal immunisation against influenza on a routine basis during inter-pandemic period Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review Influenza vaccines in healthy children Influenza vaccines in healthy children Immunopathology of RSV infection: prospects for developing vaccines without this complication The use of health economics to guide drug development decisions: determining optimal values for an RSV-vaccine in a model-based scenario-analytic approach Hospitalization for respiratory syncytial virus infection in young children: development of a clinical prediction rule Anticipated costs of hospitalization for respiratory syncytial virus infection in young children at risk Mortality in children from influenza and respiratory syncytial virus Respiratory syncytial virus or influenza? Respiratory syncytial virus infection in elderly adults Influenza-and RSV-associated hospitalizations among adults Influenza-and respiratory syncytial virus-associated mortality and hospitalisations Respiratory illness associated with influenza and respiratory syncytial virus infection The causes and diagnosis of influenza-like illness Incidence of influenza and associated illness in children aged 0-19 years: a systematic review Respiratory viruses and influenza-like illness: a survey in the area of Rome Clinical effectiveness of influenza vaccination in persons younger than 65 years with high-risk medical conditions: the PRISMA study The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children The duration and magnitude of influenza epidemics: a study of surveillance data from sentinel general practices in England, Wales and the Netherlands Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial Influenza vaccination in the prevention of acute otitis media in children NHG-Standaard Otitis media acuta bij kinderen (M09) Prevalence of various respiratory viruses in the middle ear during acute otitis media Role of respiratory viruses in children with acute otitis media Primary care management of respiratory tract infections in Dutch preschool children Influenza-and respiratory syncytial virus-associated morbidity and mortality in the nursing home population Association of influenza vaccination and reduced risk of recurrent myocardial infarction Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly Epidemiological studies: a practical guide Morbidity profiles of patients consulting during influenza and respiratory syncytial virus active periods Influenza and respiratory syncytial virus morbidity among 0-19 aged group in Yunus Emre Health Center Mortality associated with influenza and respiratory syncytial virus in the United States Contribution of respiratory syncytial virus, influenza and parainfluenza viruses to acute respiratory infections in Hospitalization attributable to influenza and other viral respiratory illnesses in Canadian children Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children Winter viruses: influenza-and respiratory syncytial virus-related morbidity in chronic lung disease In contrast to antibiotics, excess prescriptions were higher during influenza periods than during RSV periods. keywords: age; groups; influenza; periods; prescriptions; risk; rsv; years cache: cord-341626-04svm6le.txt plain text: cord-341626-04svm6le.txt item: #285 of 303 id: cord-341923-jwckbdnb author: To, Kelvin Kai-Wang title: Pathogenesis of pandemic H1N1 2009 influenza virus infection and the implication on management date: 2010-04-28 words: 5857 flesch: 38 summary: Treatment with convalescent plasma for influenza A (H5N1) infection Pre-and postexposure use of human monoclonal antibody against H5N1 and H1N1 influenza virus in mice: viable alternative to oseltamivir Logistical feasibility and potential benefits of a population-wide passive-immunotherapy program during an influenza pandemic H1N1 influenza A virusassociated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment A rationale for using steroids in the treatment of severe cases of H5N1 avian influenza Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus Confronting an influenza pandemic with inexpensive generic agents: can it be done? Binding of influenza virus to host cell surface glycoproteins or glycolipids is mediated by viral hemagglutinin (HA), and amino acid substitution in HA could affect the binding. keywords: cases; disease; h1n1; h5n1; human; infection; influenza; load; oseltamivir; pandemic; patients; swine; virus cache: cord-341923-jwckbdnb.txt plain text: cord-341923-jwckbdnb.txt item: #286 of 303 id: cord-342519-tjr6dvtt author: Souza, Thiago Moreno L. title: H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis date: 2010-11-30 words: 5170 flesch: 42 summary: Because the analysis of this novel viral infection in cancer patients is an important component of the 2009 pandemics, we conducted a prospective cohort study aimed at evaluating the clinical course of influenza infection, the duration of viral shedding, H1N1pdm evolution and the emergence of antiviral resistance in hospitalized cancer patients with a severe H1N1pdm infection in a reference cancer center during the winter of 2009 in Brazil. Prolonged influenza A H1N1pdm shedding was observed in cancer patients. keywords: cancer; days; h1n1pdm; infection; influenza; oseltamivir; pandemic; patients; shedding; table; virus cache: cord-342519-tjr6dvtt.txt plain text: cord-342519-tjr6dvtt.txt item: #287 of 303 id: cord-342796-f7n8sxbu author: Stowe, J. title: Interactions between SARS-CoV-2 and Influenza and the impact of coinfection on disease severity: A test negative design date: 2020-09-18 words: 3924 flesch: 36 summary: To estimate influenza infection on the risk of SARS-CoV-2 infection, univariable and multivariable analyses on the odds of SARS-CoV-2 in those who tested positive for influenza compared to those who tested negative for influenza. Effect of influenza infection on the risk of SARS-CoV-2 infection: The total number of positive and negative SARS-CoV-2 and influenza test results from weeks 1 to 17, 2020 were assessed. keywords: coinfection; cov-2; individuals; influenza; preprint; risk; sars cache: cord-342796-f7n8sxbu.txt plain text: cord-342796-f7n8sxbu.txt item: #288 of 303 id: cord-343050-1pfqgvie author: Huang, Qiu Sue title: Southern Hemisphere Influenza and Vaccine Effectiveness Research and Surveillance date: 2015-06-09 words: 6057 flesch: 19 summary: [67] It was designed to monitor trends in severe influenza disease and to best capture the majority of influenza respiratory disease to estimate the burden of influenza-associated respiratory hospitalizations, and risk factors for severe disease. However, the evidence to support valid and precise estimates of influenza disease burden globally remains weak with low quality, partly due to the short duration of studies and the heterogeneity of study settings and methods (statistical modelling, active versus passive case findings, virological versus clinical detection). keywords: associated; burden; disease; effectiveness; infection; influenza; pandemic; risk; sari; shivers; surveillance; vaccine cache: cord-343050-1pfqgvie.txt plain text: cord-343050-1pfqgvie.txt item: #289 of 303 id: cord-345020-ai5tib7h author: Price, O. H. title: Using routine testing data to understand circulation patterns of influenza A, respiratory syncytial virus and other respiratory viruses in Victoria, Australia date: 2019-06-17 words: 4187 flesch: 35 summary: The impact of pandemic influenza A (H1N1) 2009 on the circulation of respiratory viruses Influenza A/H1N1 2009 pandemic and respiratory virus infections Early occurrence of influenza A epidemics coincided with changes in occurrence of other respiratory virus infections Possible interference between seasonal epidemics of influenza and other respiratory viruses in Hong Kong The interferon response circuit: induction and suppression by pathogenic viruses In vitro growth profiles of respiratory syncytial virus in the presence of influenza virus Investigating viral interference between influenza a virus and human respiratory syncytial virus in a Ferret model of infection Interval between infections and viral hierarchy are determinants of viral interference following influenza virus infection in a ferret model Genotypic diversity, circulation patterns, and co-detections among rhinoviruses in Queensland Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values Do rhinoviruses reduce the probability of viral co-detection during acute respiratory tract infections Rate and influence of respiratory virus co-infection on pandemic (H1N1) influenza disease Communicable Diseases Australia (CDA) -National Notifiable Diseases Surveillance System (NNDSS) From May 2002 to December 2017, 58 114 clinical specimens were collected from communities and hospitals and tested by polymerase chain reaction (PCR) for respiratory virus infection at VIDRL. keywords: epidemics; infection; influenza; rsv; virus; viruses cache: cord-345020-ai5tib7h.txt plain text: cord-345020-ai5tib7h.txt item: #290 of 303 id: cord-345836-74d2mb70 author: Hogg, William title: The costs of preventing the spread of respiratory infection in family physician offices: a threshold analysis date: 2007-11-13 words: 6020 flesch: 41 summary: The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6963/7/181/pre pub Mathematical summary -amortization of training costs. We selected a discount factor of 5 percent as recommended by other papers containing cost analyses [4, 6, 7] . keywords: care; costs; health; infection; influenza; intervention; offices; practices; rate; training cache: cord-345836-74d2mb70.txt plain text: cord-345836-74d2mb70.txt item: #291 of 303 id: cord-345848-s84lxe6l author: Everitt, Aaron R. title: IFITM3 restricts the morbidity and mortality associated with influenza date: 2012-03-25 words: 4581 flesch: 45 summary: Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and humans. Together these data reveal that the action of a single intrinsic immune effector, IFITM3, profoundly alters the course of influenza virus infection in mouse and man. keywords: fig; genotype; human; ifitm3; infection; influenza; lungs; mice; pandemic; protein; supp; virus; −/− cache: cord-345848-s84lxe6l.txt plain text: cord-345848-s84lxe6l.txt item: #292 of 303 id: cord-346063-7u1a198p author: De Clercq, Erik title: Avian influenza A (H5N1) infection: targets and strategies for chemotherapeutic intervention date: 2007-05-04 words: 3501 flesch: 33 summary: The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a onceweekly dosing regimen Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern World Health Organization Global Influenza Program Surveillance Network (2005) Evolution of H5N1 avian influenza viruses in Asia Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam Heterocyclic rimantadine analogues with antiviral activity Broad-spectrum antiviral activity of virazole: 1-b-D-ribofuranosyl-1,2,4-triazole-3-carboxamide Lack of effect of oral ribavirin in naturally occurring influenza I Absence of interferon in lungs from fatal cases of influenza Protection against lethal influenza virus challenge by RNA interference in vivo Inhibition of influenza virus production in virusinfected mice by RNA interference Inhibition of respiratory viruses by nasally administered siRNA Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in rhesus macaque Inhibition of influenza virus transcription by 2 0 -deoxy-2 0 -fluoroguanosine Mechanism of action of T-705 against influenza virus A novel antiviral agent which inhibits the endonuclease of influenza viruses A novel class of potent influenza virus inhibitors: polysubstituted acylthiourea and its fused heterocycle derivatives Sialidase fusion protein as a novel broadspectrum inhibitor of influenza virus infection Triple antiviral therapy with amantadine for IFN-ribavirin nonresponders with recurrent posttransplantation hepatitis C Clues to the virulence of H5N1 viruses in humans PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses Large-scale sequence analysis of avian influenza isolates Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004 keywords: avian; h5n1; influenza; inhibitors; neuraminidase; oseltamivir; virus; viruses cache: cord-346063-7u1a198p.txt plain text: cord-346063-7u1a198p.txt item: #293 of 303 id: cord-346906-1wmp43ti author: Lewandowski, Kuiama title: Metagenomic Nanopore Sequencing of Influenza Virus Direct from Clinical Respiratory Samples date: 2019-12-23 words: 6771 flesch: 36 summary: To our knowledge, this is the first report of successfully applying metagenomic Nanopore sequencing directly to respiratory samples to detect influenza virus and generate influenza virus sequences. Having demonstrated our ability to retrieve influenza virus sequences from pooled influenza virus-positive material diluted with negative samples, we next applied our methods to individual anonymized clinical samples, with 40 samples testing influenza virus positive and 10 samples testing influenza virus negative in the clinical diagnostic laboratory. keywords: copies; data; fig; genome; influenza; min; nanopore; reads; rna; samples; sensitivity; sequence; sequencing; time; virus cache: cord-346906-1wmp43ti.txt plain text: cord-346906-1wmp43ti.txt item: #294 of 303 id: cord-350593-bvmg7f15 author: McDonald, R.S. title: Proportional mouse model for aerosol infection by influenza date: 2012-08-21 words: 6567 flesch: 41 summary: A two-year study of contagion in a tuberculosis ward Possible increased pathogenicity of pandemic (H1N1) 2009 influenza virus upon reassortment The use of an animal model to study transmission of influenza virus infection Experimental transmission of influenza virus infection in mice. Their low cost, small size, relative susceptibility to the virus and ease of handling make mice a favourable platform for studying influenza virus infections. keywords: aerosol; dose; exposure; infection; influenza; mice; min; mouse; pcr; study; tcid; time; virus cache: cord-350593-bvmg7f15.txt plain text: cord-350593-bvmg7f15.txt item: #295 of 303 id: cord-351990-aham72b9 author: Radin, Jennifer M. title: Epidemiology of Pathogen-Specific Respiratory Infections among Three US Populations date: 2014-12-30 words: 4514 flesch: 38 summary: This population is also highly vaccinated for influenza and showed the smallest amount of influenza infection compared with the other two populations. In our 5-24 year olds we found fever, cough, and short time to seeking care to be predictive of influenza infection. keywords: age; fever; infections; influenza; pathogen; populations; rhinovirus; study cache: cord-351990-aham72b9.txt plain text: cord-351990-aham72b9.txt item: #296 of 303 id: cord-352984-mzv9t7ex author: Jackson-Lee, Angela title: Mandating influenza vaccinations for health care workers: analysing opportunities for policy change using Kingdon’s agenda setting framework date: 2016-09-29 words: 3945 flesch: 40 summary: In the case of mandatory influenza vaccinations for HCWs in Ontario, it seems highly unlikely that a new policy will be adopted until perception of the problem’s importance is sufficient to overcome the political opposition to implementing a solution and thus, create a window of opportunity that is open long enough to support change. Mandatory influenza vaccination, the arbitrator decided, was a forced medical act and therefore, contravened the Charter (St. Peter's Health System v. CUPE local 778, 2002) keywords: care; hcws; health; immunization; influenza; mandatory; ontario; policy; vaccination cache: cord-352984-mzv9t7ex.txt plain text: cord-352984-mzv9t7ex.txt item: #297 of 303 id: cord-353869-l53ms3q8 author: Friesen, Robert H. E. title: New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets date: 2010-02-08 words: 4686 flesch: 40 summary: The results presented here also confirm previously reported data demonstrating the prophylactic and therapeutic efficacy of CR6261 in mice challenged with H5N1 influenza viruses. A recently discovered class of human monoclonal antibodies with the ability to neutralize a broad spectrum of influenza viruses (including H1, H2, H5, H6 and H9 subtypes) has the potential to prevent and treat influenza in humans. keywords: animals; challenge; control; cr6261; ferrets; group; h5n1; influenza; virus cache: cord-353869-l53ms3q8.txt plain text: cord-353869-l53ms3q8.txt item: #298 of 303 id: cord-353871-mzw600ys author: Kowalczyk, D. title: The Activity of Influenza and Influenza-like Viruses in Individuals Aged over 14 in the 2015/2016 Influenza Season in Poland date: 2017-02-15 words: 1712 flesch: 44 summary: Influenza is an infectious viral disease of the respiratory system, caused by influenza viruses belonging to Orthomyxoviridae. Improperly treated infections caused by influenza viruses can lead to complications and consequently to death. keywords: cases; influenza; season; viruses cache: cord-353871-mzw600ys.txt plain text: cord-353871-mzw600ys.txt item: #299 of 303 id: cord-354151-psog34u3 author: van Asten, Liselotte title: Early occurrence of influenza A epidemics coincided with changes in occurrence of other respiratory virus infections date: 2015-12-11 words: 4230 flesch: 30 summary: The estimated proportion of all positive diagnostics captured by this national surveillance varies between the monitored pathogens and was estimated between 38% (for rotavirus) and 73% (for influenza virus) in a 2002 study of five pathogens. While those reports hypothesize on viral interference between influenza virus and rhinovirus circulation (with rhinovirus delaying influenza spread), 1-3,17 we (like the Beijing study 16 ) did not observe clear-cut trends in rhinovirus reports in our laboratory diagnoses data. keywords: data; epidemics; influenza; laboratory; seasons; virus; viruses cache: cord-354151-psog34u3.txt plain text: cord-354151-psog34u3.txt item: #300 of 303 id: cord-354690-ywb9krdp author: Barr, Margo title: Pandemic influenza in Australia: Using telephone surveys to measure perceptions of threat and willingness to comply date: 2008-09-15 words: 3842 flesch: 45 summary: key: cord-354690-ywb9krdp authors: Barr, Margo; Raphael, Beverley; Taylor, Melanie; Stevens, Garry; Jorm, Louisa; Giffin, Michael; Lujic, Sanja title: Pandemic influenza in Australia: Using telephone surveys to measure perceptions of threat and willingness to comply date: 2008-09-15 journal: BMC Infect Dis DOI: 10.1186/1471-2334-8-117 sha: doc_id: 354690 cord_uid: ywb9krdp BACKGROUND: Baseline data is necessary for monitoring how a population perceives the threat of pandemic influenza, and perceives how it would behave in the event of pandemic influenza. When the indicators for pandemic influenza likelihood, concern for self and family and changed life were combined, as shown in Figure 1 , the greatest proportion of the population (41.3%) thought pandemic influenza was unlikely to occur, would not be concerned for themselves or their family, and had not changed the way they lived their life because of the possibility of pandemic influenza. keywords: face; health; influenza; mask; pandemic; population; questions cache: cord-354690-ywb9krdp.txt plain text: cord-354690-ywb9krdp.txt item: #301 of 303 id: cord-354877-n5du3bqt author: Vasoo, Shawn title: Rapid Antigen Tests for Diagnosis of Pandemic (Swine) Influenza A/H1N1 date: 2009-10-01 words: 1785 flesch: 40 summary: Rapid influenza antigen tests (point-of-care tests) might prove useful, because they have a fast turnaround time (10-15 min) and require minimal training to perform. However, there are few data on the diagnostic accuracy of rapid influenza antigen tests for pandemic influenza A/H1N1 virus [6] . keywords: antigen; h1n1; influenza; tests; virus cache: cord-354877-n5du3bqt.txt plain text: cord-354877-n5du3bqt.txt item: #302 of 303 id: cord-355374-e8k72955 author: Clemens, E. Bridie title: Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine date: 2018-03-26 words: 14183 flesch: 32 summary: The state of current knowledge of influenza T cell responses in humans is still trying to catch up with the lessons we have learned from animal models. Therefore, increasing the standard of care potentially offered by T cell vaccines should be considered in the context of pandemic preparedness and zoonotic infections, and in combination with improved antibody vaccine targeting methods. keywords: cd4; cd8; cell; epitopes; hla; human; immune; immunity; infection; influenza; lung; memory; pandemic; protection; responses; specific; t cell; trm; vaccine; virus; viruses cache: cord-355374-e8k72955.txt plain text: cord-355374-e8k72955.txt item: #303 of 303 id: cord-356188-rwf78stz author: Oshansky, Christine M. title: The human side of influenza date: 2012-07-01 words: 9533 flesch: 27 summary: Studies of innate and adaptive immune responses to influenza virus infection have been restricted primarily to animal models of disease and inflammation. A virus lacking the NS1 gene replicates in interferon-deficient systems Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein Monocyte-mediated defense against microbial pathogens Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus Chemokine regulation of the inflammatory response to a low-dose influenza infection in CCR2Ϫ/Ϫ mice TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection Fatal outcome of pandemic H1N1 2009 influenza virus infection is associated with immunopathology and impaired lung repair, not enhanced viral burden in pregnant mice Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules CXCR2 is required for neutrophil recruitment to the lung during influenza virus infection, but is not essential for viral clearance Type I interferon signaling regulates Ly6C monocytes and neutrophils during acute viral pneumonia in mice nate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus Influenza keywords: a(h1n1)pdm09; antibody; cells; children; h1n1; human; individuals; infection; influenza; monocytes; pandemic; responses; role; studies; vaccination; vaccine; virus; viruses cache: cord-356188-rwf78stz.txt plain text: cord-356188-rwf78stz.txt