        item: #1 of 38
          id: cord-000627-gvzs9vxr
      author: Yang, Ya-Ling
       title: Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children
        date: 2011-12-22
       words: 1936
      flesch: 41
     summary: A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan Kawasaki disease: infection, immunity and genetics Kawasaki syndrome Kawasaki disease in Korea Epidemiologic features of Kawasaki disease in Taiwan Increasing incidence of Kawasaki disease in Japan: Nationwide survey Association of lower eosinophil-related T helper 2 (Th2) cytokines with coronary artery lesions in Kawasaki disease Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki disease Association between a novel human coronavirus and kawasaki disease Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan Lack of association between New Haven coronavirus and Kawasaki disease Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells CLEC5A (MDL-1) is a novel PU.1 transcriptional target during myeloid differentiation CLEC5A is critical for dengue-virus-induced lethal disease Expression and functional role of MDL-1 (CLEC5A) in mouse myeloid lineage cells Immunological profile of peripheral blood lymphocytes and monocytes/macrophages in Kawasaki disease Induction of MCP1, CCR2, and iNOS expression in THP-1 macrophages by serum of children late after kawasaki disease Persistent monocytosis after intravenous immunoglobulin therapy correlated with the development of coronary artery lesions in patients with Kawasaki disease Evidence for RANTES, monocyte chemotactic protein-1, and macrophage inflammatory protein-1β expression in Kawasaki disease Production and expression of Gro-α and RANTES by peripheral blood mononuclear cells Isolated from patients with Kawasaki disease and measles Class II major histocompatibility antigen expression on coronary arterial endothelium in a patient with Kawasaki disease Kawasaki disease Gene-gene and gene-environment interactions on IgE production in prenatal stage Itpkc single nucleotide polymorphism associated with the kawasaki disease in a taiwanese population How C-type lectins detect pathogens The C-type lectin-like domain superfamily Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease Advances in Kawasaki disease ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms ITPKC gene SNP rs28493229 and Kawasaki disease in Taiwanese children Clinical implication of the C allele of the ITPKC gene SNP rs28493229 in kawasaki disease: association with disease susceptibility and BCG scar reactivation Transforming growth factor-β signaling pathway in patients with Kawasaki disease The SYK tyrosine kinase: a crucial player in diverse biological functions Association of mannose-binding lectin gene polymorphisms with Kawasaki disease in the Japanese Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease Kawasaki disease is characterized by systemic vasculitis of unknown etiology.
    keywords: clec5a; disease; kawasaki; lectin; patients
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        item: #2 of 38
          id: cord-003713-n3o8lwu4
      author: Min, Dong Eun
       title: High antistreptolysin O titer is associated with coronary artery lesions in patients with Kawasaki disease
        date: 2018-11-07
       words: 2784
      flesch: 50
     summary: Therefore, we hypothesized that KD patients diagnosed with concurrent streptococcal infection have poor prognoses, with respect to treatment response and development of coronary artery lesions. 14, 15) We hypothesized that KD patients diagnosed with strep tococcal infec tion have poor prognoses, especially in terms of treat ment response and the development of coronary artery lesions.
    keywords: aso; coronary; disease; group; patients; titer
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        item: #3 of 38
          id: cord-007277-86lynlxn
      author: Kenneth, McIntosh
       title: Coronaviruses in the Limelight
        date: 2005-02-15
       words: 2015
      flesch: 38
     summary: Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China The severe acute respiratory syndrome Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children Association between a novel human coronavirus and Kawasaki disease Identification of a new human coronavirus A previously undescribed coronavirus associated with respiratory disease in humans Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease Polymerase activity in lymphocyte culture supernatants from patients with Kawasaki disease Active or recent parvovirus B19 infection in children with Kawasaki disease Detection of Epstein-Barr virus DNA in cardiac and aortic tissues from chronic, active Epstein-Barr virus infection associated with Kawasaki disease-like coronary artery aneurysms Demonstration of Chlamydia pneumoniae in cardiovascular tissues from children with Kawasaki disease Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome Kawasaki syndrome: description of two outbreaks in the United States Investigation of Kawasaki syndrome risk factors in Colorado Effect of specific humoral immunity and some non-specific factors on resistance of volunteers to respiratory coronavirus infection Detection of human coronavirus 229E in nasal washings using RNA:RNA hybridisation The time course of the immune response to experimental coronavirus infection of man IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease Oligoclonal IgA response in the vascular wall in acute Kawasaki disease Detection of antigen in bronchial epithelium and macrophages in acute Kawasaki disease by use of synthetic antibody Kawasaki syndrome Cutting edge: CD8 T cell-mediated demyelination is IFN-gamma dependent in mice infected with a neurotropic coronavirus Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease The linking of an agent to Kawasaki disease follows a long trail of previously failed or still-struggling attempts to identify the etiologic agent of this important syndrome, ranging from an unidentified retrovirus [16] , to parvovirus B19
    keywords: coronavirus; disease; hcov; kawasaki
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        item: #4 of 38
          id: cord-017161-lcqrd4v0
      author: Eleftheriou, Despina
       title: The Molecular Biology and Treatment of Systemic Vasculitis in Children
        date: 2012-02-23
       words: 13331
      flesch: 28
     summary: vasculitis A randomized, placebo-controlled trial of prednisone in early Henoch Schonlein purpura Early prednisone therapy in Henoch-Schonlein purpura: a randomized, double-blind, placebo-controlled trial Prevention and treatment of renal disease in Henoch-Schonlein purpura: a systematic review Randomised placebo controlled trial to assess the role of early prednisolone on the development and progression of Henoch-Schonlein purpura nephritis Treatment of complicated Henoch-Schonlein Purpura with mycophenolate mofetil: a retrospective case series report Therapy for children with Henoch-Schonlein purpura nephritis: a systematic review Cyclosporin A for the treatment of severe Henoch-Schonlein glomerulonephritis Severe Henoch-Schonlein nephritis: resolution with azathioprine and steroids Treating severe Henoch-Schonlein and IgA nephritis with plasmapheresis alone Risk of long term renal impairment and duration of follow up recommended for Henoch-Schönlein purpura with normal or minimal urinary fi ndings: a systematic review Acute febrile mucocutaneous syndrome with lymphoid involvement with speci fi c desquamation of the fi ngers and toes in children Kawasaki disease: an evidence based approach to diagnosis, treatment, and proposals for future research Kawasaki syndrome Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young Recognition and management of Kawasaki disease Incidence of Kawasaki disease in Japan: the nationwide surveys of 1999-2002 Kawasaki syndrome hospitalizations in the United States Rising incidence of Kawasaki disease in England: analysis of hospital admission data Kawasaki disease: update on pathogenesis Medium-size-vessel vasculitis Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan V restricted T cell adherence to endothelial cells: a mechanism for superantigen dependent vascular injury Superantigens: mechanism of T-cell stimulation and role in immune responses Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease Selective expansion of T cells expressing T-cell receptor variable regions V beta 2 and V beta 8 in Kawasaki disease Prevalence of superantigen-secreting bacteria in patients with Kawasaki disease Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease Detection of antigen in bronchial epithelium and macrophages in acute Kawasaki disease by use of synthetic antibody Coronary arthritis in mice following the systemic injection of group b Lactobacillus casei cell walls in aqueous suspension Variable expression of Lactobacillus casei cell wall-induced coronary arteritis: an animal model of Kawasaki's disease in selected inbred mouse strains Presence of IFN-g does not indicate its necessity for induction of coronary arteritis in an animal model of Kawasaki disease TNF-g is necessary for induction of coronary artery in fl ammation and aneurysm formation in an animal model of Kawasaki disease Involvement of innate and adaptive immunity in a murine model of coronary arteritis mimicking Kawasaki disease The role of co-stimulation in sustaining the immune response in Kawasaki disease The role of toll-like receptor 2 (TLR2) in an animal model of Kawasaki disease TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease Matrix metalloproteinase 9 activity leads to elastin breakdown in an animal model of Kawasaki disease Inhibition of transforming growth factor b worsens elastin degradation in a murine model of Kawasaki disease ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease Association of IL 1Ra gene polymorphism, but no association of IL 1 and IL 4 gene polymorphisms, with Kawasaki disease
    keywords: aav; activation; anca; anti; antibodies; association; cells; children; cyclophosphamide; disease; endothelial; gene; granulomatosis; henoch; hsp; kawasaki; patients; pr3; purpura; therapy; treatment; vasculitis; wegener
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        item: #5 of 38
          id: cord-017245-kxqh32ip
      author: Sharma, Avinash
       title: Kawasaki Disease
        date: 2016-06-02
       words: 4096
      flesch: 53
     summary: Such patients are said to have refractory KD. Several Japanese investigators [ 22 -24 ] have put forth risk scoring systems for predicting refractory KD.
    keywords: children; coronary; disease; fever; incidence; ivig; kawasaki
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        item: #6 of 38
          id: cord-018638-4pyjhpbk
      author: Pilania, Rakesh Kumar
       title: Kawasaki Disease
        date: 2019-10-30
       words: 5677
      flesch: 47
     summary: The global epidemiology of Kawasaki disease: review and future perspectives Epidemiologic features of Kawasaki disease in Shanghai from Epidemiologic survey of Kawasaki disease in Jilin from 1999 through Epidemiological and clinical characteristics of Kawasaki disease and factors associated with coronary artery abnormalities in East China: nine years experience Epidemiologic study on Kawasaki disease in Beijing from Is Kawasaki disease incidence rising in Chandigarh Descriptive epidemiology of Kawasaki disease in Japan Genetics of Kawasaki disease: what we know and don't know The genetics of Kawasaki disease Dissecting Kawasaki disease: a state-of-the-art review Variations in ORAI1 gene associated with Kawasaki disease Transforming growth factor-beta signaling pathway in patients with Kawasaki disease Is Kawasaki disease an infectious disorder? Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study Histopathological aspects of cardiovascular lesions in Kawasaki disease Spatial and temporal clustering of Kawasaki syndrome cases The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition) Kawasaki disease in infants below 6 months: a clinical conundrum Arthritis presenting during the acute phase of Kawasaki disease BCG site reactivation in Kawasaki disease Controversies in diagnosis and management of Kawasaki disease Acute kidney injury in patients with Kawasaki disease Pulmonary presentation of Kawasaki disease-a diagnostic challenge Acute anterior uveitis as the presenting feature of Kawasaki disease Kawasaki disease as a cause of encephalitis Kawasaki disease and the pediatric gastroenterologist: a diagnostic challenge Pyuria in patients with Kawasaki disease High risk of coronary artery aneurysms in infants younger than 6 months of age with Kawasaki disease Mortality in children with Kawasaki disease: 20 years of experience from a tertiary care centre in North India Kawasaki disease in older children and adolescents Clinical assessment of coronary arteries in Kawasaki disease: focus on echocardiographic assessment Not just coronary arteritis, Kawasaki disease is a myocarditis, too Myocarditis and Kawasaki disease Early differentiation of Kawasaki disease shock syndrome and toxic shock syndrome in a pediatric intensive care unit Kawasaki disease in a pediatric intensive care unit: a case-control study Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan Kawasaki disease in India: increasing awareness or increased incidence? Biomarkers for diagnosis of Kawasaki disease Screening of differentially expressed genes associated with Kawasaki disease by microarray analysis Pro-brain natriuretic peptide (ProBNP) levels in North Indian children with Kawasaki disease Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2013).
    keywords: acute; artery; caas; children; diagnosis; disease; fever; guidelines; kawasaki; patients; phase
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        item: #7 of 38
          id: cord-024189-t7mbsr25
      author: Weyand, Cornelia M.
       title: Vasculitides
        date: 2008
       words: 26662
      flesch: 38
     summary: The P-ANCA pattern, which usually corresponds to the presence of MPO-ANCA in vasculitis patients, occurs in approximately 10% of patients with WG, but is more typical of MPA, the CSS, and renal-limited vasculitis. No pathognomic test for PMR is available; exclusion of other diseases with similar clinical presentations is essential.
    keywords: ammation; ammatory; anca; arteries; arteritis; artery; biopsy; blood; cases; cell; diagnosis; disease; figure; gca; glucocorticoids; immune; infi; infl; involvement; kawasaki; lesions; manifestations; ndings; pan; patients; renal; symptoms; syndrome; system; therapy; tissue; treatment; vascular; vasculitis; vessel; years
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        item: #8 of 38
          id: cord-027870-cuvfy4pj
      author: Baselga, Eulalia
       title: Inflammatory and Purpuric Eruptions
        date: 2020-06-22
       words: 18223
      flesch: 39
     summary: Response to dapsone A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan Kawasaki syndrome Kawasaki disease Kawasaki disease: recent advances Kawasaki disease in infants less than one year of age Clinical spectrum of Kawasaki disease in infants younger than 6 months of age Classical Kawasaki disease in a neonate Lethal vasculitis of coronary arteries in a neonate and two infants: possible neonatal variant of the MLNS/IPN complex? Myocarditis and coronary dilatation in the 1st week of life: neonatal incomplete Kawasaki disease? Kawasaki disease: what is the epidemiology telling us about the etiology? Kawasaki syndrome in the United States 1976 to 1980 Incidence survey of Kawasaki disease in 1997 and 1998 in Japan Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan Kawasaki disease in families Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young The perineal eruption of Kawasaki syndrome Psoriatic eruption in Kawasaki disease Development of psoriatic lesions during acute and convalescent phases of Kawasaki disease Guttate psoriasis following Kawasaki disease Annular pustules in Kawasaki disease: a further case indicating the association with psoriasis? Peripheral gangrene associated with Kawasaki disease Kawasaki disease characterized by erythema and induration at the Bacillus Calmette-Guérin and purifi ed protein derivate inoculation sites Skin complications of Bacillus Calmette-Guérin immunization BCG reactivation: a useful diagnostic tool even for incomplete Kawasaki disease Infl ammation at a previous inoculation site: an unusual presentation of Kawasaki disease Diagnosis and therapy of Kawasaki disease in children Kawasaki disease: more patients are being diagnosed who do not meet American Heart Association criteria Infl ammatory pulmonary nodules in Kawasaki disease Acute respiratory distress syndrome in a child with Kawasaki disease Hemophagocytic syndrome after Kawasaki disease Sensorineural hearing loss and Kawasaki disease: A prospective study Pathogenesis and treatment of Kawasaki's disease Kawasaki disease: infection, immunity and genetics Kawasaki disease: what is the epidemiology telling us about the etiology? Development of coronary artery lesions in Kawasaki disease patients in relation to plasma interferon-gamma and interleukin-4 levels in the acute phase Circulating soluble CD23 levels in Kawasaki disease with coronary artery lesions High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease Immunopathology and cytokine detection in the skin lesions of patients with Kawasaki disease Circulating soluble L-selectin levels in Kawasaki disease with coronary artery lesions Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease Kawasaki disease in siblings Familial occurrence of Kawasaki syndrome in North America Clinical features of patients with Kawasaki disease whose parents had the same disease Serum cholesterol levels during and after Kawasaki disease Altered lipid profi le after Kawasaki syndrome Diagnosing Kawasaki syndrome: the need for a new clinical tool Diagnosis, treatment and outcome of Kawasaki disease in an Australian tertiary setting: a review of three years experience National survey of coronary artery bypass grafting for coronary stenosis caused by Kawasaki disease in Japan Mortality among persons with a history of Kawasaki disease in Japan: can paediatricians safely discontinue follow-up of children with a history of the disease but without cardiac sequelae? Mortality among persons with a history of Kawasaki disease in Japan: the fi fth look Longterm outcomes in patients with giant aneurysms secondary to Kawasaki disease Long-term consequences of Kawasaki disease. Urticaria in infants is often misdiagnosed as erythema multiforme, acute hemorrhagic edema, annular erythema of infancy, or Kawasaki disease.
    keywords: acute; anti; cases; children; ciency; clinical; congenital; cutaneous; defi; disease; eruption; erythema; erythropoietic; fig; heart; infants; infl; kawasaki; kawasaki disease; lesions; lupus; neonatal; nle; onset; patients; porphyria; protein; purpura; skin; sweet; syndrome; treatment; urticaria
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        item: #9 of 38
          id: cord-030192-ebsh62ll
      author: Winant, Abbey J.
       title: Thoracic Imaging Findings of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: What Radiologists Need to Know Now
        date: 2020-07-30
       words: 4308
      flesch: 28
     summary: 4, 5, 13, 16 Given the current lack of available information related to the thoracic imaging findings of pediatric MIS-C associated with COVID-19 infection, the purpose of this article is to provide an up-to-I n p r e s s date review of the clinical and imaging features of pediatric MIS-C associated with COVID-19 infection, compared with acute pediatric COVID-19 infection, with an emphasis on thoracic imaging findings. In addition, while the incidence of Kawasaki disease is highest in Asia, strikingly, there have been no reported cases of MIS-C in Asia, despite being an early hotspot of COVID-19 infection, with some of the earliest published series on acute pediatric COVID-19 infection emerging from China.
    keywords: children; covid-19; disease; imaging; infection; mis; patients; pediatric
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        item: #10 of 38
          id: cord-253056-765rs3e7
      author: Dionne, Audrey
       title: Profile of resistance to IVIG treatment in patients with Kawasaki disease and concomitant infection
        date: 2018-10-17
       words: 3727
      flesch: 41
     summary: Although concomitant infection does not affect coronary outcome, it is unknown how it influences the response to IVIG treatment. Retrospective cohort study between 2008 and 2016 in a tertiary pediatric university hospital, including 154 children, of which 59 (38%) had concomitant infection.
    keywords: children; infection; ivig; patients; treatment
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        item: #11 of 38
          id: cord-256642-payjduek
      author: Muthuvelu, Sobana
       title: Measles infection causing Bacillus Calmette-Guérin reactivation: a case report
        date: 2019-07-24
       words: 2784
      flesch: 43
     summary: Measles infection has not been reported to cause BCG reactivation. We report the unusual finding of BCG reactivation in an infant with laboratory-confirmed measles.
    keywords: bcg; disease; measles; patient; reactivation; site
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        item: #12 of 38
          id: cord-259996-uhrhsrky
      author: Lee, Seul Bee
       title: Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms
        date: 2015-07-16
       words: 3530
      flesch: 48
     summary: Jordan-Villegas et al. 12) has shown that 2.4% of KD patients had adenovirus in their respiratory tract, and 5 of 6 KD patients with concomitant adenovirus infection had incomplete KD. Jordan-Villegas et al. 12) found that children with KD who had respiratory virus infections had a higher incidence of coronary artery dilatation than KD patients without viral infections, and the former group were more often diagnosed with incomplete KD.
    keywords: children; disease; group; kawasaki; patients; symptoms; viruses
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        item: #13 of 38
          id: cord-261058-yu2qw02l
      author: Burgner, David
       title: Kawasaki disease: What is the epidemiology telling us about the etiology?
        date: 2005-06-03
       words: 5150
      flesch: 30
     summary: The value of isolated populations in genetic studies of allergic diseases Kawasaki disease in parents and children Kawasaki syndrome Kawasaki disease: review of risk factors for coronary aneurysms Coronary risks after high-dose gamma-globulin in children with Kawasaki disease Clinical relevance of the risk factors for coronary artery inflammation in kawasaki disease Coronary artery involvement in Kawasaki syndrome in Manhattan Cytokines predict coronary aneurysm formation in Kawasaki disease patients Raised serum interleukin 15 levels in Kawasaki disease Urinary neopterin as a predictive marker of coronary artery abnormalities in Kawasaki syndrome Genetic influence on cytokine production and fatal meningococcal disease Kawasaki disease: the mystery continues Increased frequency of alleles associated with elevated tumor necrosis factor-alpha levels in children with Kawasaki disease High incidence of angiotensin I converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease HLA antigens in Kawasaki disease HLA antigens in mucocutaneous lymph node syndrome in New England Problems of reporting genetic associations with complex outcomes The HLA class II region and susceptibility to Kawasaki disease Polymorphism of transmembrane region of MICA gene and Kawasaki disease Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease Mapping disease genes: family-based association studies Control of confounding of genetic associations in stratified populations The TDT and other family-based tests for linkage disequilibrium and association Identification of susceptibility loci for insulindependent diabetes mellitus by trans-racial gene mapping The diagnosis and management of Kawasaki disease Adenovirus infection in patients with Kawasaki disease Could a herpesvirus be the cause of Kawasaki disease? Mycoplasma infection and Kawasaki disease Probable role of Streptococcus pyogenes in Kawasaki disease Serologic evidence that streptococcal superantigens are not involved in the pathogenesis of Kawasaki disease Variant Streptococcus sanguis as an etiological agent of Kawasaki disease Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome The absence of evidence of staphylococcal toxin involvement in the pathogenesis of Kawasaki disease Variant strain of Propionibacterium acnes: a clue to the etiology of Kawasaki disease Pathogenicity of Propionibacterium acnes isolated from Kawasaki disease patients-cytopathogenic protein (CPP) isolated from P. acnes culture filtrates and measurement of the antibody against CPP Positive Ehrlichia canis serology in Kawasaki disease Kawasaki disease in European adult associated with serological response to Coxiella burneti Role of house dust mites in Kawasaki disease Urine mercury levels in Kawasaki disease Rug shampoo and Kawasaki disease Association of rug shampooing and Kawasaki disease Clinical and epidemiologic characteristics of patients referred for evaluation of possible Kawasaki disease.
    keywords: artery; children; data; disease; etiology; incidence; kawasaki; kawasaki disease; studies; syndrome
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        item: #14 of 38
          id: cord-269170-9f460xbq
      author: Kaneko, Kazunari
       title: Our Evolving Understanding of Kawasaki Disease Pathogenesis: Role of the Gut Microbiota
        date: 2020-07-24
       words: 4608
      flesch: 22
     summary: Front Pediatrics A presumed etiology of kawasaki disease based on epidemiological comparison with infectious or immune-mediated diseases The gut microbiota-host partnership as a potential driver of kawasaki syndrome Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Short-chain fatty acids regulate cytokines and Th17/Treg cells in human peripheral blood mononuclear cells in vitro Butyrateproducing gut bacteria and viral infections in kidney transplant recipients: a pilot study Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT Diversity, metabolism and microbial ecology of butyrateproducing bacteria from the human large intestine Atopic predilection among kawasaki disease patients: a crosssectional study of 1,187,757 teenagers Increased risk of atopic dermatitis in preschool children with kawasaki disease: a population-based study in taiwan Atopic diathesis in patients with kawasaki disease The role of gut microbiota in atopic asthma and allergy, implications in the understanding of disease pathogenesis Previous antibiotic use and the development of kawasaki disease: a matched-pair casecontrol study The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing The microbiome in early life: implications for health outcomes Breastfeeding and risk of kawasaki disease: a nationwide longitudinal survey in Japan Shaping microbiota during the first 1000 days of life We thank Edanz Group (https://en-author-services.edanzgroup. com/) for editing a draft of this manuscript. Report of the first four Italian cases Presence in kawasaki disease of antibodies to mycobacterial heat-shock protein HSP65 and autoantibodies to epitopes of human HSP65 cognate antigen Ehrlichia chaffeensis and rochalimaea antibodies in kawasaki disease Kawasaki disease in European adult associated with serological response to coxiella burneti Tropospheric winds from northeastern China carry the etiologic agent of kawasaki disease from its source to Japan Murine model of kawasaki disease induced by mannoprotein-betaglucan complex, CAWS, obtained from Candida albicans Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-beta-glucan complex (CAWS) CAWS administration increases the expression of interferon γ and complement factors that lead to severe vasculitis in DBA/2 mice COVID-19 and kawasaki disease in children Kawasaki-like disease: emerging complication during the COVID-19 pandemic An outbreak of severe kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study Kawasaki disease linked to COVID-19 in children Parents with a history of kawasaki disease whose child also had the same disease A genome-wide association study identifies three new risk loci for kawasaki disease Common variants in CASP3 confer susceptibility to kawasaki disease Genome-wide association study identifies FCGR2A as a susceptibility locus for kawasaki disease ITPKC functional polymorphism associated with kawasaki disease susceptibility and formation of coronary artery aneurysms Transforming growth factor-beta signaling pathway in patients with kawasaki disease Variations in ORAI1 gene associated with kawasaki disease Relationship of climate, ethnicity and socioeconomic status to kawasaki disease in San Diego county Increased kawasaki disease incidence associated with higher precipitation and lower temperatures Association of early social environment with the onset of pediatric kawasaki disease Th17-and treg-related cytokine and mRNA expression are associated with acute and resolving kawasaki disease The T helper type 17/regulatory T cell imbalance in patients with acute kawasaki disease CD25+CD4+ regulatory T cells in patients with kawasaki disease Infliximab regulates monocytes and regulatory T cells in kawasaki disease
    keywords: bacteria; cells; children; disease; dysbiosis; gut; human; kawasaki; microbiota; patients
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        item: #15 of 38
          id: cord-270035-1e1wzdri
      author: Cazzaniga, Marco
       title: SARS-COV-2 Infection and Kawasaki Disease: Case Report of a Hitherto Unrecognized Association
        date: 2020-07-03
       words: 2078
      flesch: 35
     summary: SARS-CoV-2 infection in children Coronavirus disease 2019(COVID-19) in Italy Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China Missed or delayed diagnosis of Kawasaki disease during the 2019 novel coronavirus disease (COVID-19) pandemic COVID-19 and Kawasaki disease: novel virus and novel case Diagnosis, treatment, and long-term management of Kawasaki disease, a scientific statement for health professionals from the American heart Kawasaki disease: guidelines of the Italian society of pediatrics, part I -definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase Viral infections associated with Kawasaki disease Concurrent respiratory viruses and Kawasaki disease COVID-19: immunopathology and its implications for therapy The surgical manifestations of the intestinal tract in Kawasaki disease Gallbladder hydrops associated with Kawasaki disease: a case report and literature review Intestinal involvement in Kawasaki disease Gastrointestinal presentation of Kawasaki disease: a red flag for severe disease? Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China Kawasaki disease complicated with macrophage activation syndrome: a systematic review On the alert for cytokine storm: immunopathology in COVID-19 MC wrote the manuscript and designed the topic. A registry of KD cases associated with SARS-COV-2 infection is currently ongoing in Italy, and hopefully results will shed light on this unusual association.
    keywords: cov-2; covid-19; disease; kawasaki; sars
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        item: #16 of 38
          id: cord-277908-d26xzean
      author: Kuo, Ho-Chang
       title: Kawasaki-like disease among Italian children in the COVID-19 era
        date: 2020-08-18
       words: 2225
      flesch: 36
     summary: Early adjunctive steroid treatment to prevent coronary artery lesions should be considered in these patients with COVID-19 Kawasaki disease. International studies suggest that home births may be as safe as hospital births for low-risk women and infants when: (1) they are part of an integrated, regulated system; (2) multiple provider options across the continuum of care are covered; (3) providers are well qualified and have the knowledge and training to manage first-line complications; (4) transfer is seamless across settings; and (5) appropriate risk assessment and risk selection occur across settings and throughout pregnancy.
    keywords: asd; birth; disease; health; information; kawasaki; risk
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        item: #17 of 38
          id: cord-278761-cqrggpmj
      author: Manus, Jean-Marie
       title: Sars-CoV-2 et Kawasaki, rapprochement à risque
        date: 2020-07-01
       words: 275
      flesch: 57
     summary: La présentation de Kawasaki-like a été comparée à la maladie de Kawasaki selon les critères de l'American Heart Des cliniciens français ont récemment établi un rapprochement entre le Covid-19 et la maladie de Kawasaki chez l'enfant très symptomatique porteur du Sars-CoV-2, à type de Kawasaki-like. Sars-CoV-2 et Kawasaki, rapprochement à risque .
    keywords: kawasaki
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        item: #18 of 38
          id: cord-280280-9jr7ekbu
      author: Bertoncelli, Deborah
       title: COVID19: potential cardiovascular issues in pediatric patients
        date: 2020-05-11
       words: 3395
      flesch: 20
     summary: Children do not seem to count for a large proportion of COVID-19 disease infections. According to a morbidity/mortality report by the Centers for Disease Control of the United States, among the pediatric cases with information on underlying conditions, the most common underlying condition after chronic lung disease was cardiovascular disease (58, 59) .
    keywords: acute; children; coronavirus; cov-2; covid-19; disease; infection; patients; sars
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        item: #19 of 38
          id: cord-283349-9x2d1qip
      author: Paolino, Jonathan
       title: Peripheral blood smears of children with multisystem inflammatory syndrome demonstrate prominence of early myeloid forms with morphologic evidence of toxic change
        date: 2020-07-24
       words: 865
      flesch: 30
     summary: There is a growing body of evidence that suggests that children have largely been spared of much of the morbidity associated with the ongoing SARS-CoV-2 pandemic 1,2 Over the last several weeks, however, there has been an increasing awareness and understanding of a hyperinflammatory shock syndrome that appears to mimic some aspects of Kawasaki disease in some pediatric patients. [3] [4] [5] The pathophysiology that underlays this syndrome has yet to be elucidated; however, the overlap in clinical presentation with Kawasaki disease may suggest a commonality.
    keywords: children; disease; kawasaki
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        item: #20 of 38
          id: cord-286607-5i406twr
      author: Esposito, Susanna
       title: The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome
        date: 2019-04-05
       words: 6229
      flesch: 14
     summary: The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease Detection of multiple superantigen genes in stools of patients with Kawasaki disease Mycoplasma pneumoniae infection in patients with Kawasaki disease Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan Effects of natural and chemically defined nutrients on Candida albicans water-soluble fraction (CAWS) vasculitis in mice Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-beta-glucan complex (CAWS) Induction of coronary arteritis with administration of CAWS (Candida albicans water-soluble fraction) depending on mouse strains Kawasaki disease may be a hyperimmune reaction of genetically susceptible children to variants of normal environmental flora The throat flora and its mitogenic activity in patients with Kawasaki disease Microbiologic studies on the small intestine in Kawasaki disease Immunohistochemical studies on small intestinal mucosa in Kawasakidisease Kawasaki disease and the pediatric gastroenterologist: a diagnostic challenge Characteristic role of intestinal microflora in Kawasaki disease The starting lineup: key microbial players in intestinal immunity and homeostasis Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide Anti-inflammatory effect of Lactobacillus casei on Shigellainfected human intestinal epithelial cells Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease Characterization of the gut microbiota of Kawasaki disease patients by metagenomic analysis Altered mucosal microbiome diversity and disease severity in Sjögren syndrome Alterations of the human gut microbiome in liver cirrhosis Eubiosis and dysbiosis: the two sides of the microbiota Further investigations of the intestinal microflora in larger cohorts of KS patients will provide clues to disentangle the pathogenesis of this disease and probably indicate disease-modifying agents or more rational KS-specific therapies.
    keywords: acute; children; disease; gut; human; immune; kawasaki; microbiota; patients; role; syndrome
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        item: #21 of 38
          id: cord-292719-n5lg43tr
      author: Chang, Luan-Yin
       title: Viral infections associated with Kawasaki disease
        date: 2014-02-01
       words: 3167
      flesch: 38
     summary: We enrolled Kawasaki disease cases that had fever for over 5 days and at least four of the following five manifestations: neck lymphadenopathy, lip fissure and/or strawberry tongue, skin rash, nonpurulent bulbar conjunctivitis, palm/sole erythema, and induration followed by periungual desquamation. KD Z Kawasaki disease; SD Z standard deviation.
    keywords: cases; children; control; disease; infections; kawasaki; syndrome
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        item: #22 of 38
          id: cord-293714-s6ezxi5r
      author: Principi, Nicola
       title: The role of infection in Kawasaki syndrome
        date: 2013-04-18
       words: 6236
      flesch: 28
     summary: The value of isolated populations in genetic studies of allergic disease High incidence of angiotensin I converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm Polymorphism of angiotensin-1converting enzyme gene and Kawasaki disease Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease Possible synergic effect of angiotensin-I converting enzyme gene insertion/deletion polymorphism and angiotensin-II type-1 receptor 1166A/C gene polymorphism on ischemic heart disease in patients with Kawasaki disease Common variants in CASP3 confer susceptibility to Kawasaki disease Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease The CCR5 (-2135C/T) polymorphism may be associated with the development of Kawasaki disease in Korean Children Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease Genetic polymorphisms in the CD40 ligand gene and Kawasaki disease Inflammatory gene polymorphisms and susceptibility to Kawasaki disease and its arterial sequelae Polymorphism of Fc gamma RIIa may affect the efficacy of gamma-globulin therapy in Kawasaki disease The involvement of Fc gamma receptor gene polymorphisms in Kawasaki disease Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease The -590 C/T and 8375 A/G interleukin-4 polymorphisms are not associated with Kawasaki disease in Taiwanese children Interleukin 6 gene promoter polymorphism is not associated with Kawasaki disease The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease Influence of interleukin 18 promoter polymorphisms in susceptibility to Kawasaki disease in Taiwan Inducible and endothelial constitutive nitric oxide synthase gene polymorphisms in Kawasaki disease Increased frequency of alleles associated with elevated tumor necrosis factor-alpha levels in children with Kawasaki disease Association of mannose-binding lectin genotype with cardiovascular abnormalities in Kawasaki disease Polymorphisms in the mannose-binding lectin gene as determinants of age-defined risk of coronary artery lesions in Kawasaki disease Modulating effects of mannose binding lectin genotype on arterial stiffness in children after Kawasaki disease Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease Polymorphism of transmembrane region of MICA gene and Kawasaki disease Circulating matrix metalloproteinases and their inhibitors in patients with Kawasaki disease Polymorphism of matrix metalloproteinase-3 promoter gene as a risk factor for coronary artery lesions in Kawasaki disease Genetic analysis of MMP gene polymorphisms in patients with Kawasaki disease Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease A polymorphism in plasma platelet-activating factor acetylhydrolase is involved in resistance to immunoglobulin treatment in Kawasaki disease Polymorphism of SLC11A1 (formerly NRAMP1) gene confers susceptibility to Kawasaki disease Transforming growth factor-beta signaling pathway in patients with Kawasaki disease Polymorphisms of transforming growth factor-b signaling pathway and Kawasaki disease in the Taiwanese population Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki disease Analysis of tumor necrosis factor-alpha production and polymorphisms of the tumor necrosis factor-alpha gene in individuals with a history of Kawasaki disease Association between levels of TNF-alpha and TNF-alpha promoter -308 A/A polymorphism in children with Kawasaki disease Tumor necrosis factor-alpha levels and promoter polymorphism in patients with Kawasaki disease in Korea Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease Vascular endothelial growth factor gene haplotypes in Kawasaki disease Association of vascular endothelial growth factor C-634 g polymorphism in Taiwanese children with Kawasaki disease Lack of association of the vascular endothelial growth factor gene polymorphisms with Kawasaki disease in Taiwanese children ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms A genome-wide association study identifies novel and functionally related susceptibility loci for Kawasaki disease A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease Identification of novel susceptibility loci for Kawasaki disease in a Han Chinese population by a genome-wide association study Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease A genome-wide association study identifies three new risk loci for Kawasaki disease Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis This review was supported by a grant from the Italian Ministry of Health (Bando Giovani Ricercatori 2007). A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan Current recommendations for the pharmacological therapy in Kawasaki syndrome and management of its cardiovascular complications Kawasaki syndrome: an intriguing disease with numerous unsolved dilemmas Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young Discrimination between incomplete and atypical Kawasaki syndrome versus other febrile diseases in childhood: results from an international registry-based study Kawasaki syndrome-like illness associated with infection caused by enterotoxin B-secreting Staphylococcus aureus Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease Lack of association between Kawasaki syndrome and infection with parvovirus B19, human herpesvirus 8, TT virus, GB virus C/hepatitis G virus or Chlamydia pneumoniae Emerging from obscurity: understanding pulmonary and extrapulmonary syndromes, pathogenesis and epidemiology of human Mycoplasma pneumonia infections Respiratory tract infections by Mycoplasma pneumoniae in children: a review of diagnostic and therapeutic measures Kawasaki disease with a concomitant primary Epstein-Barr virus infection Adenovirus type 2 isolated from a patient with fatal Kawasaki disease Kawasaki disease and parvovirus B19 infection in an adult HIV-1-infected patient Isolation of human herpesvirus-6 from an infant with Kawasaki disease Kawasaki disease associated with Klebsiella pneumoniae bacteremia and parainfluenza type 3 virus infection Kawasaki disease associated with measles virus infection in a monozygotic twin Association of rotavirus infection with Kawasaki syndrome Concomitant dengue hemorrhagic fever with Kawasaki disease Kawasaki disease associated with chickenpox: report of two sibling cases Kawasaki disease coincident with influenza A H1N1/09 infection Kawasaki syndrome and concurrent Coxsackie-virus B3 infection Kawasaki disease in England: ethnicity, deprivation, and respiratory pathogens Association between a novel human coronavirus and Kawasaki disease Detection of human bocavirus in children with Kawasaki disease Kawasaki disease and human bocavirus e potential association?
    keywords: associated; association; children; disease; gene; incidence; infection; kawasaki; kawasaki disease; patients; polymorphism; susceptibility; syndrome
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        item: #23 of 38
          id: cord-294729-c9f0iokr
      author: Orr, William B.
       title: Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed
        date: 2020-10-01
       words: 2627
      flesch: 23
     summary: Our representative case of a patient with coronavirus disease-19-associated multisystem inflammatory syndrome in children without robust hyperinflammation and a delayed finding of coronary artery dilatation compared with reported case series highlights the need for further mechanistic understanding of coronavirus disease-19 disease and subsequent multisystem inflammatory syndrome in children or Kawasaki disease development. Conclusion: Our representative case of a patient with coronavirus disease-19-associated multisystem inflammatory syndrome in children without robust hyperinflammation and a delayed finding of coronary artery dilatation compared with reported case series highlights the need for further mechanistic understanding of coronavirus disease-19 disease and subsequent multisystem inflammatory syndrome in children or Kawasaki disease development.
    keywords: children; coronavirus; covid-19; disease; mis; multisystem; syndrome
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        item: #24 of 38
          id: cord-299870-4ulmbn1r
      author: Ferrara, Giovanna
       title: Anakinra for Treatment-Resistant Kawasaki Disease: Evidence from a Literature Review
        date: 2020-09-03
       words: 5135
      flesch: 47
     summary: Several case reports of KD patients treated with anakinra have been published (nine single cases, a series of two, and a series of 11); their main characteristics are summarized in Table 1 . While awaiting the results of the trials currently finished and of those which are ongoing or planned, we acknowledge the possible role of anakinra for KD patients who do not respond to a first IVIG infusion.
    keywords: anakinra; day; disease; il-1; ivig; kawasaki; patients; treatment
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        item: #25 of 38
          id: cord-300216-3mvfiuwc
      author: Montenegro-Villalobos, Jiulliana
       title: Subconjunctival Acute Bilateral Hemorrhages Due to Kawasaki Disease in a Costa Rican Girl: An Unusual Clinical Manifestation of the Disease
        date: 2020-09-02
       words: 1585
      flesch: 35
     summary: Ocular manifestations of Kawasaki's disease (mucocutaneous lymph node syndrome) Prospective study of Kawasaki disease complications: review of 115 cases Conjunctival changes in children with Kawasaki disease: cytopathologic characterization Conjunctival biopsy in patients with Kawasaki disease Usefulness of anterior uveitis as an additional tool for diagnosing incomplete Kawasaki disease Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease Rare ocular manifestations in an 11-year-old girl with incomplete Kawasaki disease: a case report A case of Kawasaki disease complicated with retinal vasculitis To our knowledge, this is the first report from Latin America and among the few in the literature of a child in whom severe bilateral subconjunctival hemorrhages occur as a manifestation of Kawasaki disease.
    keywords: disease; kawasaki; patients
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        item: #26 of 38
          id: cord-301107-0njnjqeb
      author: Dursun, Recep
       title: The Clinics of HHV‐6 infection in COVID‐19 pandemic: Pityriasis rosea and Kawasaki disease
        date: 2020-05-31
       words: 1704
      flesch: 46
     summary: SARS-CoV-2, which is the cause of COVID-19 disease, is not actually a dermatotrophic virus. However, various cutaneous manifestations associated with the disease have been reported to develop during COVID-19 disease (3, 6) .
    keywords: disease; outpatient; patients
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        item: #27 of 38
          id: cord-301160-7ik3iszp
      author: Lee, Kyung-Yil
       title: Kawasaki Disease: Laboratory Findings and an Immunopathogenesis on the Premise of a "Protein Homeostasis System"
        date: 2012-03-01
       words: 8972
      flesch: 37
     summary: A streptococcal pathogenesis Some of The infectious etiology of vasculitis Intestinal microflora of Estonian and Swedish infants Intestinal colonization with Enterobacteriaceae in Pakistani and Swedish hospital-delivered infants High-dose intravenous gammaglobulin for Kawasaki disease Kawasaki syndrome; Rheumatic complains and analysis of salicylate therapy Inflammatory processes in Kawasaki disease reach their peak at the sixth day of fever onset: laboratory profiles according to duration of fever Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease Intravenous gamma-globulin treatment in Kawasaki disease Epidemiologic study of Kawasaki disease at a single hospital in Daejeon Predictors of coronary artery lesions after intravenous gamma-globulin treatment in Kawasaki disease Prediction of non-responsiveness to intravenous high-dose gamma-globulin therapy in patients with Kawasaki disease at onset Immunoglobulin failure and retreatment in Kawasaki disease Prediction of non-responsiveness to standard high-dose gamma-globulin therapy in patients with acute Kawasaki disease before starting initial treatment Analysis of potential risk factors associated with nonresponse to initial intravenous immunoglobulin treatment among Kawasaki disease patients in Japan Limitation of prediction on intravenous immunoglobulin responsiveness in Kawasaki disease Ethnic differences in C-reactive protein concentrations Efficacy of intravenous immune globulin therapy combined with dexamethasone for the initial treatment of acute Kawasaki disease Keloids: current concepts of pathogenesis (review) To control the action of pathogenic proteins and/or substances from the injured cells, immune cells are activated.
    keywords: cals; cells; disease; fever; immune; inflammation; ivig; kawasaki; kawasaki disease; non; patients; proteins; responders; treatment
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        item: #28 of 38
          id: cord-304533-qwbbsg14
      author: Jones, Imogen
       title: An adult presentation consistent with PIMS-TS
        date: 2020-07-10
       words: 276
      flesch: 46
     summary: 4, 5 To the best of our knowledge, this is the first reported case of adult Kawasaki like disease related to SARSCoV2 infection. A case of complete adultonset Kawasaki disease: a review of pathogenesis and classification Kawasakilike syndromes in HIVinfected adults
    keywords: sarscov2
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        item: #29 of 38
          id: cord-309317-cgs0sui7
      author: Galeotti, Caroline
       title: Autoimmune and inflammatory diseases following COVID-19
        date: 2020-06-04
       words: 1632
      flesch: 35
     summary: Therefore, it is critical to make the fine distinction between classical Kawasaki disease and Kawasaki disease associated with COVID-19 (KD-COVID-19). In fact, although the French 3 and Italian 1 studies suggest that patients are negative for common viruses that trigger Kawasaki disease, data from other European countries reveal appearance of PIMS, with clinical and biochemical features distinct from that of classical Kawasaki disease and affecting children up to 17 years old.
    keywords: cov-2; covid-19; disease; sars
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        item: #30 of 38
          id: cord-312486-rumqopg0
      author: Jacob, Chaim Oscar
       title: On the genetics and immunopathogenesis of COVID-19
        date: 2020-09-10
       words: 11535
      flesch: 38
     summary: -1 beta in macrophages Influence of glutamine on cytokine production by human gut in vitro Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts A whole-genome association study of major determinants for host control of HIV-1 IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes LY6E impairs coronavirus fusion and confers immune control of viral disease Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Imbalanced host response to SARS-CoV-2 drives development of COVID-19 Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome Virus-host interactome and proteomic survey of PBMCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis Immunology of COVID-19: current state of the science Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Host and environmental factors influencing individual human cytokine responses COVID-19: consider cytokine storm syndromes and immunosuppression A single-cell atlas of the peripheral immune response in patients with severe COVID-19 Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis of macrophage activation syndrome Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage Dysregulation of immune response in patients with COVID-19 in Wuhan, China Heightened innate immune responses in the respiratory tract of COVID-19 patients Clinical features of patients infected with 2019 novel coronavirus in Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice Complement evasion strategies of viruses: an overview The Complement System in COVID-19: Friend and Foe? Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation. Functional exhaustion of antiviral lymphocytes in COVID-19 patients Clinical and immunological features of severe and moderate coronavirus disease 2019 Complex immune dysregulation in COVID-19 patients with severe respiratory failure Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent Coronaviruses and immunosuppressed patients: the facts during the third epidemic Uneventful course in patients with inflammatory bowel disease during the severe acute respiratory syndrome coronavirus 2 Outbreak in Northern Italy Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly decimates human spleens and lymph nodes Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implication Longitudinal analyses reveal immunological misfiring in severe COVID-19 Mouse model of SARS-CoV-2 reveals inflammatory role of type I Interferon signaling Persistence of memory in times of COVID-19 Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls No one is naïve: the significance of heterologous T-cell immunity Heterologous immunity between viruses Heterologous T cell immunity in severe hepatitis C virus infection Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing Neutralizing Antibody Responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications Convergent antibody responses to SARS-CoV-2 in convalescent individuals Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses Viral kinetics and antibody responses in patients with COVID-19.
    keywords: ace2; activation; cells; children; complement; coronavirus; cov-2; covid-19; cytokine; disease; expression; host; human; infection; patients; response; risk; sars; syndrome; system; virus
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        item: #31 of 38
          id: cord-314662-nem6dw34
      author: Nakra, Natasha A.
       title: Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management
        date: 2020-07-01
       words: 5549
      flesch: 33
     summary: The epidemiology and pathogenesis of Kawasaki disease Association between a novel human coronavirus and Kawasaki disease The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease Recognition of a Kawasaki disease shock syndrome Kawasaki disease: An unexpected etiology of shock and multiple organ dysfunction syndrome Kawasaki disease shock syndrome: Unique and severe subtype of Kawasaki disease Structure-based preliminary analysis of immunity and virulence of SARS coronavirus Toxic shock syndrome in children: Epidemiology, pathogenesis, and management Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: A systematic review and meta-analysis Early differentiation of Kawasaki disease shock syndrome and toxic shock syndrome in a pediatric intensive care unit On the alert for cytokine storm: Immunopathology in COVID-19 Macrophage activation syndrome in the era of biologic therapy DNA viremia is associated with hyperferritinemia in pediatric sepsis Hemophagocytic lymphohistiocytosis and infections: An update Macrophage activation syndrome in the acute phase of Kawasaki disease Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis Calm in the midst of cytokine storm: A collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome Marked hyperferritinemia does not predict for HLH in the adult population HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A European league against rheumatism/American college of rheumatology/paediatric rheumatology international trials organisation collaborative initiative Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease-The SHARE initiative Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease Intravenous immunoglobulin plus corticosteroid to prevent coronary artery abnormalities in Kawasaki disease: A meta-analysis Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): A randomised, open-label, blinded-endpoints trial Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm Coronary-artery aneurysm in tocilizumab-treated children with Kawasaki's disease Long-term efficacy and safety of tocilizumab in giant cell arteritis and large vessel vasculitis Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: An increased risk for candidemia? As compared to other children with KD, patients with Kawasaki disease shock syndrome (KDSS) have higher band counts, lower platelet counts, lower hemoglobin levels, and higher C-reactive protein levels
    keywords: children; cov-2; disease; immune; infection; kawasaki; mis; patients; sars; syndrome; treatment
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        item: #32 of 38
          id: cord-315001-1ui27pkc
      author: Peterson, Nicholas
       title: Discovering Associations: Kawasaki Disease and COVID-19
        date: 2020-09-28
       words: 1597
      flesch: 49
     summary: e patient's mother had been working in a respiratory clinic during the COVID-19 pandemic, where patients presented for COVID-19 testing if they exhibited concerning symptoms; she reported wearing proper personal protective equipment (PPE) during all patient encounters at her workplace. COVID-19 testing resulted early in the course of admission but did not alter the management of the patient.
    keywords: covid-19; disease; fever; kawasaki; patient
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        item: #33 of 38
          id: cord-323202-kcy8xoos
      author: Burns, Jane C.
       title: Temporal Clusters of Kawasaki Disease Cases Share Distinct Phenotypes That Suggest Response to Diverse Triggers
        date: 2020-09-22
       words: 3488
      flesch: 45
     summary: The universe of cluster cases was randomly re-allocated to 47 groups of the same size as the true observed temporal clusters. In the univariate analysis, cluster-level averages of demographic and clinical characteristics were compared between the set of 47 true KD clusters and 100 sets of 47 synthetic clusters of equal size created either by randomly shuffling membership of cluster cases (referred to as shuffled clusters) or by randomly creating clusters from non-cluster cases of Kawasaki disease within the same season as the true cluster (referred to as control clusters).
    keywords: cases; characteristics; clusters; disease; kawasaki
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        item: #34 of 38
          id: cord-331249-jrzgqq8q
      author: del Castillo Martín, Fernando
       title: Enfermedad de kawasaki
        date: 2006-06-30
       words: 7638
      flesch: 44
     summary: El exantema de la enfermedad de Kawasaki es un gran simulador y su interpretación exclusiva conduce frecuentemente a errores diagnósticos 41 . El exantema de la enfermedad de Kawasaki es muy variado (polimorfo)
    keywords: aguda; aneurismas; aunque; años; casos; como; con; criterios; de la; del; diagnóstico; disease; días; embargo; enfermedad; enfermos; esta; este; exantema; fase; fiebre; hay; kawasaki; la enfermedad; las; lesiones; lesión; los; menores; más; niños; para; pero; por; puede; que; ser; sin; son; syndrome; una
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        item: #35 of 38
          id: cord-333145-a20dlaxn
      author: Johnson, Todd A.
       title: Association of an IGHV3-66 gene variant with Kawasaki disease
        date: 2020-10-26
       words: 6446
      flesch: 41
     summary: In previous literature, polyclonal activation and increase of B cells [34, 35] and detection of auto-antibodies against components of vascular endothelial cells or neutrophils in peripheral blood of acute KD patients have been documented [36, 37] . However, a recent transcriptomic study revealed downregulation of genes related to BCR signaling in acute KD patients [39] .
    keywords: analyses; association; disease; ighv3; kawasaki; patients; region; rs6423677; snvs; study; supplementary; susceptibility; table
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        item: #36 of 38
          id: cord-342372-2g9sq36w
      author: Zhu, Frank H.
       title: The Clinical Diagnosis and Management of Kawasaki Disease: a Review and Update
        date: 2016-09-28
       words: 5966
      flesch: 39
     summary: Additionally, no bacterial toxin has been detected in the peripheral blood of KD patients making such a toxin unlikely to be responsible for the diffuse inflammation found in acute KD Kawasaki shock syndrome, the presentation of KD disease with systolic hypotension or clinical signs of poor perfusion, has also been described as a rare presentation of KD
    keywords: abnormalities; artery; coronary; disease; features; fever; ivig; kawasaki; patients; treatment
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        item: #37 of 38
          id: cord-343387-7el80yby
      author: Gallizzi, Romina
       title: Kawasaki disease epidemic: pitfalls
        date: 2020-08-27
       words: 1027
      flesch: 40
     summary: Kawasaki disease (KD) is a vasculitis of the small and medium caliber vessels with a preference for coronary arteries and it is the most common cause of heart disease acquired in children [1] . Ital J Pediatr DOI: 10.1186/s13052-020-00887-4 sha: doc_id: 343387 cord_uid: 7el80yby Recent reports have described in the pediatric population a new type of hyperinflammatory response manifested following contact with SARS-CoV-2, with some of the clinical features attributable to Kawasaki disease (KD).
    keywords: disease; kawasaki; sars
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        item: #38 of 38
          id: cord-353229-k3zerr83
      author: Akca, Ummusen Kaya
       title: Kawasaki-like disease in children with COVID-19
        date: 2020-09-16
       words: 4380
      flesch: 38
     summary: Coronavirus Disease 2019 in Children-United States Epidemiology and clinical features of coronavirus disease 2019 in children Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China New spectrum of COVID-19 manifestations in children: Kawasaki-like syndrome and hyperinflammatory response Predictors of COVID-19 severity: a literature review Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children Viral infections associated with Kawasaki disease Association between a novel human coronavirus and Kawasaki disease Kawasaki disease and infection Detection of Epstein-Barr virus DNA in cardiac and aortic tissues from chronic, active Epstein-Barr virus infection associated with Kawasaki disease-like coronary artery aneurysms An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study Hyperinflammatory shock in children during COVID-19 pandemic Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children Pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort Multisystem inflammatory syndrome in US children and adolescents Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association COVID-19 and Kawasaki disease: novel virus and novel case SARS-CoV-2-induced kawasaki-like hyperinflammatory syndrome: a novel COVID phenotype in Children Incomplete Kawasaki disease in a child with COVID-19 COVID-19 associated pediatric multi-system inflammatory Syndrome Erythema multiforme and Kawasaki disease associated with COVID-19 infection in children Multisystem inflammatory syndrome in children during the COVID-19 pandemic: a case series Features of COVID-19 post-infectious cytokine release syndrome in children presenting to the emergency department Dermatological manifestation of pediatrics multisystem inflammatory syndrome associated with COVID-19 in a 3-year-old girl Multisystem inflammatory syndrome with features of atypical Kawasaki disease during COVID-19 pandemic A case of pediatric multisystem inflammatory syndrome temporally associated with COVID-19 in South Dakota Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 Toxic shock-like syndrome and COVID-19: a case report of multisystem inflammatory syndrome in children (MIS-C) Patterns of myocardial involvement in children during COVID-19 pandemic: Early experience from northern Italy COVID-19 multisystem inflammatory syndrome in three teenagers with confirmed SARS-CoV-2 infection Paediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2 (PIMS-TS): cardiac features, management and short-term outcomes at a UK Tertiary Paediatric Hospital Multisystem Inflammatory Syndrome Related to COVID-19 in previously healthy children and adolescents in New York City Severe COVID-19 in children and young adults in the Washington, DC metropolitan region Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis Cardiac MRI of children with multisystem inflammatory syndrome (MIS-C) associated with COVID-19: case series Serology confirms SARS-CoV-2 infection in PCR-negative children presenting with Paediatric Inflammatory Multi-System Syndrome Incomplete Kawasaki disease as presentation of COVID-19 infection in an infant: a case report Kawasaki Disease features and myocarditis in a patient with COVID-19 Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children SARS-COV-2 Infection and Kawasaki Disease: case report of a Hitherto Unrecognized Association. This finding suggests that we should maintain a high index of suspicion for incomplete KD in COVID-19 patients.
    keywords: children; covid-19; disease; incomplete; kawasaki; manuscript; multisystem; patients; sars; syndrome
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