# bib

id: cord-327601-4uqgwlnx
author: Bangash, Mansoor N.
title: SARS-CoV-2: is the liver merely a bystander to severe disease?
date: 2020-06-02
extension: .txt
mime: text/plain
words: 979
sentence: 36
flesch: 31
cache: cache/cord-327601-4uqgwlnx.txt
txt: txt/cord-327601-4uqgwlnx.txt
summary:
  Based on the above perspectives, we feel that raised liver aminotransferases associated with SARS-CoV-2 positivity are more likely attributable to illness severity, in which host response and iatrogenic harm (i.e. drugs, ventilation) drive bystander liver injury, thus explaining its association with mortality and in an analogous fashion to patterns seen in sepsis. The fact that increases in liver aminotransferases occur and tend to parallel the severity of pulmonary disease remains unquestioned 2 , however, whether the liver injury is a true viral hepatitis rather than a bystander to the multi-organ pathophysiology of critical illness requires further discussion.


id: cord-303046-unksl7p4
author: Pawlotsky, Jean-Michel
title: COVID-19 and the liver-related deaths to come
date: 2020-06-11
extension: .txt
mime: text/plain
words: 1904
sentence: 53
flesch: 24
cache: cache/cord-303046-unksl7p4.txt
txt: txt/cord-303046-unksl7p4.txt
summary:
  However, the greatest effect of COVID-19 on liver diseases will be indirect and delayed, resulting from the impending global economic crisis. Patients with cirrhosis seem to be at greater risk than other individuals for severe COVID-19 and the occurrence of complications, including mortality, regardless of the aetiology COVID-19 and the liver-related deaths to come www.nature.com/nrgastro of liver disease 6, 7 .


id: cord-324509-5c6fzdjm
author: Huang, Haijun
date: 2020-07-22
extension: .txt
mime: text/plain
words: 2159
sentence: 103
flesch: 43
cache: cache/cord-324509-5c6fzdjm.txt
txt: txt/cord-324509-5c6fzdjm.txt
title:
  The association between markers of liver injury and clinical outcomes in patients with COVID‐19 in Wuhan

summary:
  On the other hand, dynamic changes in liver functions may indicate a certain relationship between liver injury and mortality. Therefore, we retrospectively analysed the clinical characteristics and dynamic changes in liver function based on different liver function levels at admission and different prognosis, in the purpose of finding out risk factors related to liver injury, and associations between markers of liver injury and clinical outcomes in COVID-19, including mortality and mechanical ventilation.


id: cord-339786-elrzlbsg
author: Gurala, Dhineshreddy
title: Acute Liver Failure in a COVID-19 Patient Without any Preexisting Liver Disease
date: 2020-08-26
extension: .txt
mime: text/plain
words: 2065
sentence: 92
flesch: 47
cache: cache/cord-339786-elrzlbsg.txt
txt: txt/cord-339786-elrzlbsg.txt
summary:
  Our patient, who had no previous history of liver disease and normal liver enzymes at presentation, developed elevated liver enzyme levels on day 4. For example, the patient's home medication coumadin is a rare cause of acute liver injury and usually results in a cholestatic pattern rather than a hepatocellular one, which is what our patient demonstrated.


id: cord-328147-61gtx2h2
author: Lopez-Mendez, Ivan
date: 2020-10-21
extension: .txt
mime: text/plain
words: 2665
sentence: 108
flesch: 44
cache: cache/cord-328147-61gtx2h2.txt
txt: txt/cord-328147-61gtx2h2.txt
title:
  Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19)

summary:
  In COVID-19 patients, the prevalence of liver steatosis and advanced liver fibrosis by noninvasive assessment prediction models was high and was not associated with clinical outcomes; 96.8% of COVID-19 patients had at least one abnormal LFT. Liver function tests (LFT) abnormalities are reported in up to 50% of COVID-19 patients, metabolic comorbidities are associated with poorer outcomes.


id: cord-283120-hyzk59qv
author: Sharma, Ashish
date: 2020-10-16
extension: .txt
mime: text/plain
words: 2636
sentence: 101
flesch: 38
cache: cache/cord-283120-hyzk59qv.txt
txt: txt/cord-283120-hyzk59qv.txt
title:
  Liver disease and outcomes among COVID-19 hospitalized patients- a systematic review and meta-analysis

summary:
  Future studies should evaluate changing levels of biomarkers amongst liver disease patients to predict poor outcomes of COVID-19 and causes of liver injury during COVID-19 infection. In severe acute respiratory syndrome (SARS) epidemic 60% of patients had hepatic injury, due to phylogenetic similarities of the viruses it is assumed that COVID-19 is associated with acute liver injury.


id: cord-355395-rckzi8vz
author: Tian, Dandan
title: Hepatic complications of COVID‐19 and its treatment
date: 2020-05-21
extension: .txt
mime: text/plain
words: 2899
sentence: 88
flesch: 28
cache: cache/cord-355395-rckzi8vz.txt
txt: txt/cord-355395-rckzi8vz.txt
summary:
  Liver injury may be a risk factor for progresses and worsens in patients with COVID‐19, and it is necessary to pay attention to the occurrence of liver injury in the diagnosis and treatment of COVID‐19. With acute liver injury, clinicians should analyze and judge the causes of liver injury and take appropriate measures, while closely monitoring ALT, AST, total bilirubin, direct bilirubin, albumin, and PTA (INR).


id: cord-275637-ea6w2kqv
author: Roca-Fernandez, A.
date: 2020-06-05
extension: .txt
mime: text/plain
words: 2915
sentence: 117
flesch: 40
cache: cache/cord-275637-ea6w2kqv.txt
txt: txt/cord-275637-ea6w2kqv.txt
title:
  HIGH LIVER FAT ASSOCIATES WITH HIGHER RISK OF DEVELOPING SYMPTOMATIC COVID-19 INFECTION - INITIAL UK BIOBANK OBSERVATIONS

summary:
  Liver fat >5% is diagnostic of fatty liver disease (19) ; liver fat >10% is considered to qualify as severe fatty liver disease and is a commonly used inclusion criteria in clinical trials of patients with non-alcoholic steatohepatitis (NASH) (20) . . Multiparametric MRI measuring liver fat and fibroinflammation has demonstrated value in characterising liver disease (12, 13) and predicting clinical outcomes (14) .


id: cord-305956-l02xdq87
author: Alqahtani, Saleh A
title: Liver injury in COVID-19: The current evidence
date: 2020-05-26
extension: .txt
mime: text/plain
words: 3066
sentence: 132
flesch: 36
cache: cache/cord-305956-l02xdq87.txt
txt: txt/cord-305956-l02xdq87.txt
summary:
  A retrospective study Liver impairment in COVID-19 patients: A retrospective analysis of 115 cases from a single center in Wuhan city, China. Cautious use of antiviral agents in patients with decompensated liver disease and drug-drug interactions in post liver transplant patients has to be considered.


id: cord-342930-f7cw2ca6
author: Portincasa, Piero
title: Hepatic consequences of COVID-19 infection. Lapping or biting?
date: 2020-06-01
extension: .txt
mime: text/plain
words: 3018
sentence: 125
flesch: 39
cache: cache/cord-342930-f7cw2ca6.txt
txt: txt/cord-342930-f7cw2ca6.txt
summary:
  This is particularly true if patients are older or have a pre-existing history of liver diseases. The mechanisms and strategies to protect from hepatic ischemia-32 reperfusion injury Liver -guardian, modifier and target of sepsis Specific ACE2 expression in cholangiocytes may 39 cause liver damage after 2019-nCoV infection Ischaemia reperfusion injury in liver 41 transplantation: Cellular and molecular mechanisms Immune responses in COVID-19 and potential vaccines: 1 Lessons learned from SARS and MERS epidemic Pathogen recognition and Toll-like receptor targeted therapeutics in innate 3 immune cells Infection of neonatal 5 mice with sindbis virus results in a systemic inflammatory response syndrome Systemic viral infections and collateral damage in the liver Evolution of the immune system in humans from infancy 10 to old age MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury signaling axis is a key mediator of hepatic ischemia-reperfusion injury Mitochondrial 17 oxidative injury in rat fatty livers exposed to warm ischemia-reperfusion The reduced 20 tolerance of rat fatty liver to ischemia reperfusion is associated with mitochondrial oxidative injury People who are at higher risk for severe illness Study of the relationship SARS and hepatitis virus B Care of patients 26 with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper The global burden of liver disease: the major 29 impact of China Prevention of SARS-CoV-2 infection in patients with 31 decompensated cirrhosis Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population 34 Utilizing Ultrasound and Liver Biopsy: A Prospective Study Systematic review: the epidemiology and natural history of 36 non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults Prevalence of 39 nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition 40 Examination Survey Changes in the prevalence 1 of the most common causes of chronic liver diseases in the United States from Exercising the hepatobiliary-gut axis.


id: cord-348024-n8wn4och
author: Lei, Fang
title: Longitudinal association between markers of liver injury and mortality in COVID‐19 in China
date: 2020-05-02
extension: .txt
mime: text/plain
words: 3207
sentence: 149
flesch: 39
cache: cache/cord-348024-n8wn4och.txt
txt: txt/cord-348024-n8wn4och.txt
summary:
  Medical history comprised coexistence of chronic obstructive pulmonary disease (COPD), type 2 diabetes mellitus (T2DM), hypertension, coronary heart disease, cerebrovascular disease, chronic liver disease, CKD, cancer, and autoimmune diseases. A total of 81 (1.4%) patients reported chronic liver disease.


id: cord-279667-ikfduu2k
author: Ronnje, Louise
date: 2020-09-04
extension: .txt
mime: text/plain
words: 3366
sentence: 159
flesch: 45
cache: cache/cord-279667-ikfduu2k.txt
txt: txt/cord-279667-ikfduu2k.txt
title:
  Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery

summary:
  [19] found that elevated levels of IL-6 were associated with a significantly increased risk of mortality in COVID-19 patients but in this case the inflammatory markers (and liver enzyme tests) decreased significantly after the Caesarean section. Atypical presentation of HELLP could not be ruled out and the importance of a multidisciplinary team in the treatment and management of severe COVID-19 during pregnancy is critical for positive patient outcome.


id: cord-332827-gll4nqdd
author: Peixe, Paula
title: Hepatology in the COVID Era: Another C Virus, again Challenging the Liver
date: 2020-04-30
extension: .txt
mime: text/plain
words: 3993
sentence: 183
flesch: 48
cache: cache/cord-332827-gll4nqdd.txt
txt: txt/cord-332827-gll4nqdd.txt
summary:
  Another concern is for patients with liver disease (either advanced or decompensated), namely, the use of drugs used off-label which have not been studied for use for the current indication or in fragile populations such as liver patients. However, COVID-19 may indeed be more severe in liver patients.


id: cord-290412-m6fesoyb
author: Zhao, Chang-qing
date: 2014-09-30
extension: .txt
mime: text/plain
words: 4276
sentence: 162
flesch: 37
cache: cache/cord-290412-m6fesoyb.txt
txt: txt/cord-290412-m6fesoyb.txt
title:
  Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities

summary:
  As complementary and alternative therapies, TCMs will play an expanding role in the future of liver disease treatment. Several patent drugs (Chinese herbal formulas) for treatment Clinical observations showed that FZHYC can effectively improve liver function and decrease the expression of fibrosis biomarkers such as serum hyaluronic acid, collagen type IV, procollagen type III and laminin, in chronic liver disease patients with fibrosis or cirrhosis [43, 44] .


id: cord-324529-xbrdtxnz
author: Wang, Ming
date: 2020-10-07
extension: .txt
mime: text/plain
words: 4055
sentence: 183
flesch: 45
cache: cache/cord-324529-xbrdtxnz.txt
txt: txt/cord-324529-xbrdtxnz.txt
title:
  Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China

summary:
  There were significant differences in laboratory findings between COVID-19 patients with or without liver injury, including higher white blood cell, neutrophil and lower lymphocyte count in liver injury patients than those without. Liver injury is a common complication in COVID-19 patients.


id: cord-318755-fip8wj6y
author: El Kassas, Mohamed
title: Liver transplantation in the era of COVID-19
date: 2020-05-12
extension: .txt
mime: text/plain
words: 4272
sentence: 188
flesch: 34
cache: cache/cord-318755-fip8wj6y.txt
txt: txt/cord-318755-fip8wj6y.txt
summary:
  Although healthcare facilities are overwhelmed with management of COVID-19 patients & health resources are being rapidly consumed, the American Association for the Study of Liver Diseases (AASLD), recommended against postponing transplantation. Immunosuppressive therapy should be started in patients with liver disease with or without COVID-19 who have strong indications for treatment (e.g., autoimmune hepatitis, liver transplant patients, and in cases of graft rejection).


id: cord-291851-xesef17i
author: Wong, Yu-Jun
title: A systematic review and meta-analysis of the COVID-19 associated liver injury
date: 2020-08-31
extension: .txt
mime: text/plain
words: 4386
sentence: 210
flesch: 47
cache: cache/cord-291851-xesef17i.txt
txt: txt/cord-291851-xesef17i.txt
summary:
  The objective of this meta-analysis is to compare the risk and clinical outcome of COVID-19 associated liver injury between COVID-19 patients with severe and non-severe COVID-19. COVID-19 associated liver injury is defined as any liver damage in patients COVID-19 patients, with or without the pre-existing liver disease [5] .


id: cord-340710-dmow5p7k
author: Lagana, Stephen M.
date: 2020-08-13
extension: .txt
mime: text/plain
words: 4542
sentence: 229
flesch: 45
cache: cache/cord-340710-dmow5p7k.txt
txt: txt/cord-340710-dmow5p7k.txt
title:
  Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data

summary:
  As the focus of this study is liver pathology, the lungs were considered only in the context of how the pulmonary findings may relate to liver injury. The role of immunosuppression and allograft recipient status on liver injury associated with COVID-19 will need further study.


id: cord-292501-2jv7xkfn
author: Jiang, Saiping
date: 2020-06-23
extension: .txt
mime: text/plain
words: 4411
sentence: 190
flesch: 41
cache: cache/cord-292501-2jv7xkfn.txt
txt: txt/cord-292501-2jv7xkfn.txt
title:
  Liver Injury in Critically Ill and Non-critically Ill COVID-19 Patients: A Multicenter, Retrospective, Observational Study

summary:
  According to the latest epidemiological studies, ∼16-53% of patients with COVID-19 experienced different degrees of liver injury (4, (7) (8) (9) (10) (11) (12) (13) , and some patients have developed severe liver injury. Although some studies have reported the incidence of liver injury in patients with COVID-19 (8, 14, 15) , there are limited data describing the course of liver injury occurrence, such as liver injury onset, progression, and recovery, during an entire hospitalization period, particularly in patients with different disease severity.


id: cord-288721-3bv3aak6
author: Schneider, Annika
date: 2019-06-11
extension: .txt
mime: text/plain
words: 5607
sentence: 226
flesch: 32
cache: cache/cord-288721-3bv3aak6.txt
txt: txt/cord-288721-3bv3aak6.txt
title:
  Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection

summary:
  Fig. 2 ) Taken together these data demonstrate that mitochondria which are in close physical proximity exchange information leading to changes in mitochondrial membrane potential but not in mitochondrial size. We chose the liver, and more specifically hepatocytes, as Viral infection increases size and mitochondrial fragility of liver mitochondria.


id: cord-300187-fr6tme32
author: Kearns, Shawn
title: Infectious Hepatopathies in Dogs and Cats
date: 2009-11-26
extension: .txt
mime: text/plain
words: 5801
sentence: 326
flesch: 31
cache: cache/cord-300187-fr6tme32.txt
txt: txt/cord-300187-fr6tme32.txt
summary:
  Disseminated infection and death have been reported in a single dog. 104, 105 In dogs, disseminated infection is most often associated with canine distemper, other infections including ehrlichiosis and immunosuppression, or vaccination with live attenuated vaccines.


id: cord-284693-mgpxnnk0
author: Jothimani, Dinesh
title: Post Liver transplant recurrent and de novo viral infections
date: 2020-09-26
extension: .txt
mime: text/plain
words: 6350
sentence: 220
flesch: 30
cache: cache/cord-284693-mgpxnnk0.txt
txt: txt/cord-284693-mgpxnnk0.txt
summary:
  Initial report from the US epicenter COVID-19 in an international European liver transplant recipient cohort COVID-19 in long-term liver transplant patients: preliminary experience from an Italian transplant centre in Lombardy Determining risk factors for mortality in liver transplant patients with COVID-19 Chronic Infection With Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries Prevalence and clinical consequences of Hepatitis E in patients who underwent liver transplantation for chronic Hepatitis C in the United States Hepatitis E virus and chronic hepatitis in organ-transplant recipients Prevalence of hepatitis E virus infection in pediatric solid organ transplant recipients--a single-center experience Prevalence of hepatitis E virus infection in liver transplant recipients Hepatitis E virus infection without reactivation in solid-organ transplant recipients, France. WHO classification of tumours of haematopoietic and lymphoid tissues Lymphomas occurring late after solid-organ transplantation: influence of treatment on the clinical outcome Posttransplantation lymphoproliferative disorder--the great mimic in liver transplantation: appraisal of the clinicopathologic spectrum and the role of Epstein-Barr virus virus and posttransplant lymphoproliferative disorder in solid organ transplantation Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial Therapeutic options in post-transplant lymphoproliferative disorders Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review Herpes Simplex Virus Principles and Practice of Infectious Diseases Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: transmission by donated organ and the effect of OKT3 antibodies Herpes Simplex Virus and Varicella-Zoster Virus Infections in Hematopoietic Stem Cell or Solid Organ Transplantation Transplant Infections Infections after liver transplantation Infections in solid-organ transplant recipients Oral acyclovir therapy for mucocutaneous herpes simplex virus infections in immunocompromised marrow transplant recipients Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans Herpes simplex virus in solid organ transplantation Incidence and risk factors for herpes zoster in patients undergoing liver transplantation Herpes zoster after liver transplantation: incidence, risk factors, and complications Varicella zoster virus in solid organ transplantation Classification of HHV-6A and HHV-6B as distinct viruses Update on human herpesvirus 6 biology, clinical features, and therapy Latent human herpesvirus 6 infection of human monocytes/macrophages The prevalence of chromosomally integrated human herpesvirus 6 genomes in the blood of UK blood donors et pediatric liver transplant patients HHV-6A, 6B, and 7: persistence in the population, epidemiology and transmission Human herpesvirus-6 infection after liver transplantation Clinical impact of human herpesvirus 6 infection after liver transplantation in syncytial giant-cell hepatitis Detection of HHV-6 in over a thousand samples: new types of infection revealed by an analysis of antigenemia related to CMV infection after liver transplantation Co-infection and clinical impact of human herpesvirus 5 and 6 in liver transplantation Human herpesvirus-6 in liver transplant recipients: role in pathogenesis of fungal infections, neurologic complications, and outcome and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection Acute hepatitis with periportal confluent necrosis associated with human herpesvirus 6 infection in liver transplant patients Encephalitis caused by human herpesvirus-6 in a liver transplant recipient Treating HHV-6 Infections Diagnosis and Clinical Management HHV-6 in liver transplantation: A literature review


id: cord-261608-4sjlg0p0
author: Trejo-Paredes, Camila
title: COVID-19-INDUCED LIVER INJURY: A CLINICAL DISTRACTION?
date: 2020-10-31
extension: .txt
mime: text/plain
words: 457
sentence: 21
flesch: 34
cache: cache/cord-261608-4sjlg0p0.txt
txt: txt/cord-261608-4sjlg0p0.txt
summary:
  We should be cognizant of other potential causes of liver injury in COVID-19 patients like concurrent infection, sepsis-induced and DILI. Although our patient lacked any known risk factors for liver injury and preexisting liver disease, he developed a significant hyperbilirubinemia and transaminitis without sequalae.


id: cord-025168-be7zube4
author: Saleh, Mahshid
title: Perspective of placenta derived mesenchymal stem cells in acute liver failure
date: 2020-05-24
extension: .txt
mime: text/plain
words: 6538
sentence: 248
flesch: 33
cache: cache/cord-025168-be7zube4.txt
txt: txt/cord-025168-be7zube4.txt
summary:
  Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies Introduction to the revised American Association for the Study of Liver Diseases Position Paper on acute liver failure Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Bone marrow-derived mesenchymal stem cells inhibits hepatocyte apoptosis after acute liver injury Acute liver failure: current trends Acute liver failure Mesenchymal stem cell transplantation for liver cell failure: a new direction and option Acute liver failure Acute liver failure Acute liver failure: an up-to-date approach Emerging strategies for the treatment of patients with acute hepatic failure Intensive care management of acute liver failure What's new in acute liver failure? Acute liver failure: redefining the syndromes Classification, etiology, and considerations of outcome in acute liver failure Mechanisms of liver damage EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure The systemic inflammatory response syndrome in acute liver failure Complications and use of intracranial pressure monitoring in patients with acute liver failure and severe encephalopathy Fulminant hepatic failure AASLD position paper: the management of acute liver failure Lactate is important in determining prognosis in acute liver failure Hepatitis E virus infection in lung transplant recipients: a case series Acute liver failure Etiologies of acute liver failure Infectious complications of acute and chronic liver disease Role of inflammation and infection in the pathogenesis of human acute liver failure: clinical implications for monitoring and therapy Herb-Induced Liver Injuries in Developing Nations: an Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis Inflammasome activation and function in liver disease Sterile inflammation in the liver Immunology in the liver-from homeostasis to disease Inflammasomes in liver diseases The impact of sterile inflammation in acute liver injury Effect of blood constituents on uptake of glucose and on metabolic rate of the brain in perfusion experiments The importance of immune dysfunction in determining outcome in acute liver failure Pathogenesis of hepatic encephalopathy in acute liver failure Infection and the progression of hepatic encephalopathy in acute liver failure SIRS score reflects clinical features of non-acetaminophen-related acute liver failure with hepatic coma Predictors of bacteraemia and mortality in patients with acute liver failure The systemic inflammatory response syndrome and sequential organ failure assessment scores are effective triage markers following paracetamol (acetaminophen) overdose Macrophage activation and polarization: nomenclature and experimental guidelines Transcriptome-based network analysis reveals a spectrum model of human macrophage activation Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9 Nonhematopoietic mesenchymal stem cells: what are they? Age-associated changes in regenerative capabilities of mesenchymal stem cell: impact on chronic wounds repair The stem-cell niche theory: lessons from flies Human placenta-derived mesenchymal stromal cells: a review from basic research to clinical applications Human bone-cell proliferation in vitro decreases with human donor age Isolation and characterization of true mesenchymal stem cells derived from human term decidua capable of multilineage differentiation into all 3 embryonic layers Comparison of human placenta-and bone marrow-derived multipotent mesenchymal stem cells DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells Aging and replicative senescence have related effects on human stem and progenitor cells Comparison of in vitro hepatogenic differentiation potential between various placenta-derived stem cells and other adult stem cells as an alternative source of functional hepatocytes Vasculogenesis Potential of Mesenchymal and Endothelial Stem Cells Isolated from Various Human Tissues. Typically, most physiological features of liver function are controlled by liver cells or hepatocytes; therefore, the loss of hepatocytes is the main cause of liver failure.


id: cord-342808-yonbowkb
author: Francque, Sven
title: Innovative liver research continues during the current pandemic
date: 2020-05-24
extension: .txt
mime: text/plain
words: 2009
sentence: 61
flesch: 30
cache: cache/cord-342808-yonbowkb.txt
txt: txt/cord-342808-yonbowkb.txt
summary:
  Patients with advanced liver disease as well as liver transplant patients likely represent vulnerable patient cohorts with an increased risk of infection and/or a severe course of COVID-19. Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable covalently closed circular DNA Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes Treating chronic hepatitis delta: the need for surrogate markers of treatment efficacy TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection PPARa gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis Combined alcoholic and non-alcoholic steatohepatitis Health-related quality of life and patient-reported outcome measures in NASH-related cirrhosis Features and outcome of AIH patients without elevation of IgG Liver transplantation for late-onset presentations of acute liver failure in Wilson's disease: the UK experience over 2 decades Hepatobiliary MR contrast agents are useful to diagnose hepatocellular carcinoma in patients with Budd-Chiari syndrome Evaluation of liver tumour response by imaging


id: cord-340576-dabcs3w5
author: Nishikawa, Hiroki
title: Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis
date: 2020-07-24
extension: .txt
mime: text/plain
words: 8158
sentence: 354
flesch: 36
cache: cache/cord-340576-dabcs3w5.txt
txt: txt/cord-340576-dabcs3w5.txt
summary:
  2017 Gut Microbiota Dysbiosis in Patients With Non-Alcoholic Fatty Liver Disease Aberrant IgA Responses to the Gut Microbiota During Infancy Precede Asthma and Allergy Development Microbiota Transfer Therapy Alters Gut Ecosystem and Improves Gastrointestinal and Autism Symptoms: An Open-Label Study Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells Development of a Novel Frailty Index to Predict Mortality in Patients With End-Stage Liver Disease Combined Albumin-Bilirubin Grade and Skeletal Muscle Mass as a Predictor in Liver Cirrhosis Health-Related Quality of Life in Chronic Liver Diseases: A Strong Impact of Hand Grip Strength Resting Energy Expenditure and Nutritional State in Patients With Liver Cirrhosis before and after Liver Transplantation Frailty Associated With Waitlist Mortality Independent of Ascites and Hepatic Encephalopathy in a Multicenter Study Sarcopenia in cirrhosis: From pathogenesis to interventions Myosteatosis and Sarcopenia Are Associated With Hepatic Encephalopathy in Patients with Cirrhosis Reduced handgrip strength is predictive of poor survival among patients with liver cirrhosis: A sex-stratified analysis Prognostic significance of low skeletal muscle mass compared with protein-energy malnutrition in liver cirrhosis Review article: Malnutrition/sarcopenia and frailty in patients with cirrhosis Energy metabolism in patients with acute and chronic liver disease Clinical Significance of Therapy Using Branched-Chain Amino Acid Granules in Patients with Liver Cirrhosis and Hepatocellular Carcinoma Sarcopenia and cognitive impairment in liver cirrhosis: A viewpoint on the clinical impact of minimal hepatic encephalopathy Efficacy of Branched-Chain Amino Acid Supplementation and Walking Exercise for Preventing Sarcopenia in Patients with Liver Cirrhosis Supplementation with branched-chain amino acids ameliorates hypoalbuminemia, prevents sarcopenia, and reduces fat accumulation in the skeletal muscles of patients with liver cirrhosis Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis Muscle atrophy as pre-sarcopenia in Japanese patients with chronic liver disease: Computed tomography is useful for evaluation The stratification of cirrhosis Slow walking speed overlapped with low handgrip strength in chronic liver disease patients with hepatocellular carcinoma Recommendation from the working group for creation of sarcopenia assessment criteria Growing research on sarcopenia in Asia Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. In addition, the energy metabolism of LC patients is in a hypercatabolic state, and when fasting early in the morning, they are in the same degree of starvation as when a healthy person fasts for 2-3 days


id: cord-009987-biop7gyd
author: Ali, Muhammad
date: 2017-10-19
extension: .txt
mime: text/plain
words: 7381
sentence: 264
flesch: 26
cache: cache/cord-009987-biop7gyd.txt
txt: txt/cord-009987-biop7gyd.txt
title:
  Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

summary:
  Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: Identification of two novel hepatitis C virus subtypes Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family A review of hepatoprotective plants used in Saudi traditional medicine. Extensive literature survey of hepatoprotective plants clearly indicates that herbal drugs have an enormous potential for the treatment of liver diseases.


id: cord-309795-2kozsv4z
author: Dewidar, Bedair
title: Metabolic liver disease in diabetes – from mechanisms to clinical trials
date: 2020-06-20
extension: .txt
mime: text/plain
words: 8655
sentence: 306
flesch: 28
cache: cache/cord-309795-2kozsv4z.txt
txt: txt/cord-309795-2kozsv4z.txt
summary:
  The Liver The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD) Role of diet and lifestyle changes in nonalcoholic fatty liver disease Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance The integrative biology of type 2 diabetes Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor alpha expression Potential Nexus of Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Insulin Resistance Between Hepatic and Peripheral Tissues Insulin resistance causes inflammation in adipose tissue Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling Serum adiponectin levels in different types of non alcoholic liver disease. BL, baseline; CCR2/5, C-C chemokine receptors type 2 and type 5; FXR, farnesoid X receptor; HbA 1c , glycated haemoglobin; LXR, Liver X receptor; MPC, mitochondrial pyruvate carrier; NA, data not available; NAFLD, non-alcoholic fatty liver disease; NFS, NAFLD fibrosis score; PPAR, peroxisome proliferator-activated receptor; NASH, non-alcoholic steatohepatitis; SCD, stearoyl-CoA desaturase; SGLT, sodium-glucose cotransporter; THR, thyroid hormone receptor; T2DM, type 2 diabetes.


id: cord-271635-tydlyc1q
author: Abdel-Hamid, Nabil M.
date: 2018-11-30
extension: .txt
mime: text/plain
words: 10071
sentence: 416
flesch: 30
cache: cache/cord-271635-tydlyc1q.txt
txt: txt/cord-271635-tydlyc1q.txt
title:
  Herbal management of hepatocellular carcinoma through cutting the pathways of the common risk factors

summary:
  Inflammation and cancer STATs in cancer inflammation and immunity: a leading role for STAT3 Infections as a major preventable cause of human cancer New functions for the matrix metalloproteinases in cancer progression Role of nonresolving inflammation in hepatocellular carcinoma development and progression, Npj Precis Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B Evaluation of the antinociceptive activity and acute oral toxicity of standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza Roxb Xanthorrhizol: a review of its pharmacological activities and anticancer properties Antiproliferative property and apoptotic effect of xanthorrhizol on MDA-MB-231 breast cancer cells Xanthorrhizol induced DNA fragmentation in HepG2 cells involving Bcl-2 family proteins Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system Berberine suppresses proinflammatory responses through AMPK activation in macrophages Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines Berberine inhibits inflammatory response and ameliorates insulin resistance in hepatocytes Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147 Berberine induces selective apoptosis through the AMPKmediated mitochondrial/caspase pathway in hepatocellular carcinoma Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 upregulation Hepatoprotective and antiviral functions of silymarin components in HCV infection Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin Identification of hepatoprotective flavonolignans from silymarin Anticancer potential of silymarin: from bench to bed side Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats Chemopreventive effect of silymarin on liver pathology in HBV X protein transgenic mice RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells Studies on mechanism of action of glycyrrhizin against hepatitis A virus replication in vitro Therapeutic basis of glycyrrhizin on chronic hepatitis B Review of pharmacological effects of Glycyrrhiza sp.


id: cord-277535-u283k70i
author: Vaja, Rakesh
title: Drugs and the liver
date: 2020-09-22
extension: .txt
mime: text/plain
words: 4015
sentence: 189
flesch: 45
cache: cache/cord-277535-u283k70i.txt
txt: txt/cord-277535-u283k70i.txt
summary:
  Prevalence of ultrarapid metabolisers Metabolism of drugs in liver disease depends on liver blood flow. NSAIDS are contraindicated for systemic use in most liver disease patients, because of increased bioavalibilty, the high risk of precipitating gastrointestinal bleeding and renal failure.


id: cord-323736-zup9cp6s
author: Ko, Sheung‐Fat
date: 2020-07-21
extension: .txt
mime: text/plain
words: 4536
sentence: 175
flesch: 32
cache: cache/cord-323736-zup9cp6s.txt
txt: txt/cord-323736-zup9cp6s.txt
title:
  Hepatic (31)P‐magnetic resonance spectroscopy identified the impact of melatonin‐pretreated mitochondria in acute liver ischaemia‐reperfusion injury

summary:
  After preparation of haematoxylin and eosin (HE) stain, the degree of liver injury was determined according to our previous report with liver injury score defined as follows: 0 indicated no notable hepatocyte integrity impairment or sinusoidal distortion; 1 corresponded to mild hepatic injury with less than 25% of section involved; 2 indicated moderate hepatic injury with 25%-50% of section involved; 3 denoted severe hepatic injury with more than 50% involved. Additionally, the Masson's trichrome stain displayed that the fibrotic area exhibited an identical pattern of liver injury score among the three groups.


id: cord-017603-wq4cgqs2
author: Shanmugam, Naresh
title: Acute Liver Failure in Children
date: 2018-10-16
extension: .txt
mime: text/plain
words: 4433
sentence: 211
flesch: 37
cache: cache/cord-017603-wq4cgqs2.txt
txt: txt/cord-017603-wq4cgqs2.txt
summary:
  Pediatr Blood Cancer Leukaemia presenting with fulminant hepatic failure in a child Autoimmune paediatric liver disease Pattern of diagnostic evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States Early indicators of prognosis in fulminant hepatic failure AASLD position paper: the management of acute liver failure N-acetylcysteine on its way to a broader application in patients with acute liver failure Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial Acute liver failure in children High-dose immunoglobulin during pregnancy for recurrent neonatal haemochromatosis Clinical human hepatocyte transplantation: current status and challenges Auxiliary liver transplantation for acute liver failure in children Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure Cell therapy for liver disease: from liver transplantation to cell factory Following infection with hepatitis A virus, the risk of developing liver failure is 0.1-0.4%, and this further increases with underlying chronic liver disease.


id: cord-018801-amet0wx4
author: Park, Caroline
title: Care of the Patient with Liver Failure Requiring Transplantation
date: 2018-05-04
extension: .txt
mime: text/plain
words: 4708
sentence: 208
flesch: 28
cache: cache/cord-018801-amet0wx4.txt
txt: txt/cord-018801-amet0wx4.txt
summary:
  Liver transplant patients may be eligible for fast-track extubation immediately postoperative in the operating room and upon arrival to the ICU. Liver transplant patients with hemorrhage that are undergoing appropriate blood product resuscitation and become hemodynamically unstable or develop abdominal compartment syndrome should return immediately to the operating room.


id: cord-018225-dozmy3lb
author: Hawker, Felicity H.
title: The liver in critical illness
date: 2008
extension: .txt
mime: text/plain
words: 6821
sentence: 274
flesch: 42
cache: cache/cord-018225-dozmy3lb.txt
txt: txt/cord-018225-dozmy3lb.txt
summary:
  The seminal paper by O'Grady and the group from King's College Hospital, London, develops criteria for liver transplantation in acute liver failure. This paper was the first large case study to document the feasibility and success of liver transplantation for acute liver failure.


id: cord-033914-a9e3rncp
author: Kauffman-Ortega, E.
date: 2020-10-17
extension: .txt
mime: text/plain
words: 1723
sentence: 65
flesch: 40
cache: cache/cord-033914-a9e3rncp.txt
txt: txt/cord-033914-a9e3rncp.txt
title:
  In memoriam Ludwig van Beethoven. Clinical history and possible diagnoses of the genius of musical composition in silence()

summary:
  None. Beethoven's autopsia revisitad: a patólogos rounds a final note A modern case sheds light on a classical enigma: Beethoven's deafness The deafness of Ludwig van Beethoven: an immunopathy Cogan syndrome: a retrospective review of 60 patients throughout half century Lead and the deafness of Ludwig Van Beethoven el genio de Bonn atormentado por sus enfermedades: historia médica Historical hepatology: Ludwig van Beethoven Beethoven's renal disease based on his autopsy: a case of papillary necrosis Acute-on-chronic liver failure Rialp: Traducción de Joaquín Esteban Perruca The virtues in medical practice Valdovinos-Díaz * Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán The authors declare that they have no conflict of interests. 1 Ludwig van Beethoven was born on December 16, 1770, in the small German city of Bonn, situated on the banks of the Rhine.


id: cord-014770-cgtzlra1
author: Brandt, Lawrence J.
title: Book reviews
date: 1995
extension: .txt
mime: text/plain
words: 5386
sentence: 237
flesch: 46
cache: cache/cord-014770-cgtzlra1.txt
txt: txt/cord-014770-cgtzlra1.txt
summary:
  Endoscopy is becoming only one of several tools made available for the clinician to tackle the complexity of gastrointestinal diseases, and this atlas is a valuable addition to the library of every gastroenterologist. Raven Press, New York, 1994, 294 pp., $131.50 .This excellent book is a summary of the Atlanta International Symposium, the presentations of 40 experts who assembled in Atlanta, Georgia, in the fall of 1992 to discuss acute pancreatitis and its complications.


id: cord-029138-avfvpqs5
author: Croome, Kristopher P.
title: The Changing Landscapes in DCD Liver Transplantation
date: 2020-07-13
extension: .txt
mime: text/plain
words: 6318
sentence: 242
flesch: 41
cache: cache/cord-029138-avfvpqs5.txt
txt: txt/cord-029138-avfvpqs5.txt
summary:
  While several tools exist in order to predict the likelihood that a DCD donor will expire within 60 min, their predictive value is moderate at best, making the decisions on which DCD liver donors to pursue challenging [17] Emerging technologies such as various forms of machine perfusion may allow for reduction of complications and better prognostication of the risk associated with DCD liver grafts.


id: cord-262152-gdnc51m5
author: Chaibi, Sayma
date: 2020-10-19
extension: .txt
mime: text/plain
words: 2770
sentence: 132
flesch: 46
cache: cache/cord-262152-gdnc51m5.txt
txt: txt/cord-262152-gdnc51m5.txt
title:
  Liver Function Test Abnormalities Are Associated With A Poorer Prognosis In Covid-19 Patients: Results Of A French Cohort

summary:
  Most of liver injuries are mild and transient during COVID-19. It might contribute to liver injury and even liver failure in patients who are critically ill.


id: cord-002272-c7f1l13s
author: Sauter, Kristin A.
date: 2016-07-21
extension: .txt
mime: text/plain
words: 6673
sentence: 276
flesch: 46
cache: cache/cord-002272-c7f1l13s.txt
txt: txt/cord-002272-c7f1l13s.txt
title:
  Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs

summary:
  To explore the role of CSF1 in steady-state control of monocyte production and differentiation and tissue repair, we previously developed a bioactive protein with a longer half-life in circulation by fusing pig CSF1 with the Fc region of pig IgG1a. We fused pig CSF1, which is equally active in all mammalian species tested (20) , with the Fc region of pig IgG1a (CSF1-Fc) (21) .


id: cord-005892-3yuznrdv
author: Hübener, P.
date: 2017-02-16
extension: .txt
mime: text/plain
words: 2155
sentence: 86
flesch: 22
cache: cache/cord-005892-3yuznrdv.txt
txt: txt/cord-005892-3yuznrdv.txt
title:
  Das akut-auf-chronische Leberversagen als diagnostische und therapeutische Herausforderung der Intensivmedizin

summary:
  The inflammatory response and immune function Acute-on-chronic liver failure: A new syndrome that will re-classify cirrhosis Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: A randomized controlled study Patients with acute on chronic liver failure display sepsis-like immune paralysis Short-term prognosis of community-acquired bacteremia in patients with liver cirrhosis or alcoholism: A population-based cohort study Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study Infections in patients with cirrhosis increase mortality fourfold and should be used in determining prognosis ClinicalCourseofacuteon-chronic liver failure syndrome and effects on prognosis Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure Acute-on-chronic liver failure: Consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis Prednisolone or Pentoxifylline for Alcoholic Hepatitis Management of critically-ill cirrhotic patients Intensive care of the patient with cirrhosis Acute-on-chronic liver failure before liver transplantation: Impact on posttransplant outcomes Acute-onchronic liver failure: Excellent outcomes after liver transplantation but high mortality on the wait list Acute-on-chronic liver failure: Terminology, mechanisms and management Bacterialinfectionsincirrhosis: A position statement based on the EASL Special Conference Management of acute-on-chronic liver failure Transfusion strategies for acute upper gastrointestinal bleeding Albumin for bacterial infections other than spontaneous bacterial peritonitis in cirrhosis. Liver failure · Cirrhosis · Infection · Organ failure · Transplantation Acute-on chronic liver failure Acute-on-chronic liver failure Toward an improved definition of acute-on-chronic liver failure Survival in infectionrelated acute-on-chronic liver failure is defined by extrahepatic organ failures Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis Lessons from look-back in acute liver failure?


id: cord-280234-anlytu3q
author: Memar, Elmira Haji Esmaeil
date: 2020-09-29
extension: .txt
mime: text/plain
words: 1550
sentence: 61
flesch: 35
cache: cache/cord-280234-anlytu3q.txt
txt: txt/cord-280234-anlytu3q.txt
title:
  Fulminant hepatic failure: a rare and devastating manifestation of Coronavirus disease 2019 in an 11-year-old boy

summary:
  key: cord-280234-anlytu3q authors: Memar, Elmira Haji Esmaeil; Mamishi, Setareh; Ekbatani, Meisam Sharifzadeh; Alimadadi, Hosein; Yaghmaei, Bahareh; Chegini, Victoria; Janani, Somayeh; Mahmoudi, Shima title: Fulminant hepatic failure: a rare and devastating manifestation of Coronavirus disease 2019 in an 11-year-old boy date: 2020-09-29 journal: Arch Pediatr DOI: 10.1016/j.arcped.2020.09.009 sha: doc_id: 280234 cord_uid: anlytu3q Although several typical manifestation of novel coronavirus disease 2019 (COVID-19) including respiratory symptoms, weakness, fever, and fatigue have been reported, some rare and novel manifestations have also been observed, particularly in children. We report a pediatric case of fulminant hepatic failure associated with COVID-19.


id: cord-016757-3d320c0a
title: Acute and chronic liver insufficiency
date: 2008
extension: .txt
mime: text/plain
words: 9789
sentence: 516
flesch: 40
cache: cache/cord-016757-3d320c0a.txt
txt: txt/cord-016757-3d320c0a.txt
summary:
  Clinical features, etiology, epidemiology, and current management Serum phosphorus levels predict clinical outcome in fulminant hepatic failure Plasma phospholipids fatty acid pattern in severe liver disease Fulminant hepatic failure as a presenting paraneoplastic manifestation of Hodgkin's disease Controlled hyperventilation in the prevention of cerebral oedema in fulminant hepatic failure Prognostic indicators in acute liver failure Fulminant hepatic failure in nonmetastatic renal cell carcinoma Fulminant Epstein-Barr viral hepatitis: orthotopic liver transplantation and review of the literature Insulin and glucagon levels in fulminant hepatic failure in man Prognostic indicators in fulminant hepatic failure Insulin and Glucagon therapy of acute hepatic failure Miliary tuberculosis presenting as hepatic and renal failure Fulminant hepatic failure after occupational exposure to 2-nitropropane Chemotherapy of Amanita phalloides poisoning with intravenous silibinin Activin A and follistatin in acute liver failure Fulminant hepatic failure caused by tuberculosis Fulminant or subfulminant non-A, non-B viral hepatitis: the role of hepatitis C and E viruses Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension Fulminant hepatic failure due to secondary amyloidosis Pilot study with polyenylphosphatidylcholine in severe liver insufficiency Controlled trial of antithrombin III supplementation in fulminant hepatic failure Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure Ratio of circulating follistatin and activin A reflects the severity of acute liver injury and prognosis in patients with acute liver failure The fulminant form of epidemic hepatitis Fulminant hepatic failure as the initial manifestation of primary hepatocellular carcinoma Fulminant hepatic failure with massive necrosis as a result of hepatitis A infection Early changes in the permeability of the blood-brain barrier produced by toxins associated with liver failure Spontaneous reactivation of chronic hepatitis B infection leading to fulminant hepatic failure Hepatic regeneration in fulminant hepatic failure Renal failure in acute liver failure Caffeine clearance and galactose elimination capacity as prognostic indicators in fulminant hepatic failure Autoimmune hepatitis presenting with acute hepatic failure Fulminant hepatic failure caused by acute fatty liver of pregnancy treated by orthotopic liver transplantation Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators The management of abnormalities of hemostasis in acute liver failure Activation of the fibrinolytic system in patients with fulminant liver failure Vorgehen bei Knollenblätterpilzvergiftung Fulminant hepatic failure after Lepiota mushroom poisoning Bacterial and fungal infection in acute liver failure L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure Acute carbon tetrachloride poisoning in 19 patients: implications for diagnosis and treatment Selective intestinal decontamination in the prevention of bacterial infection in patients with acute liver failure Acute liver failure due to non-Hodgkin's lymphoma Efficacy of hepatic arterial infusion of prostaglandin E1 in the treatment of postoperative acute liver failure. Ϫ Report of a case Gc-globulin and prognosis in acute liver failure Energy metabolism in acute hepatic failure Prognostic value of hepatic volumetry in fulminant hepatic failure The pathophysiological basis of acuteon-chronic liver failure Variants of hepatitis B virus associated with fulminant liver disease Acute liver failure: clinical features, outcome analysis, and applicability of prognostic criteria Treatment of fulminant hepatic failure with intravenous prostaglandin E1 Brain edema in liver failure: basic physiologic principles and management Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure Prospective assessment of incidence of fulminant hepatitis in post-transfusion hepatitis: a study of 504 cases Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes Role of hepatitis C virus in German patients with fulminant and subfulminant hepatic failure Fulminante Hepatitis bei Listeriensepsis Fulminant herpes hepatitis in a healthy adult.


id: cord-018318-vzzrsqsn
author: Naidu, C. Sudeep
title: Postoperative Liver Failure
date: 2017-02-08
extension: .txt
mime: text/plain
words: 9074
sentence: 420
flesch: 38
cache: cache/cord-018318-vzzrsqsn.txt
txt: txt/cord-018318-vzzrsqsn.txt
summary:
  Liver stiffness correlated well with ICGR15 in liver resection patients, and predicted early postoperative complications and was recommended, to provide 'better prognostic information for patients undergoing resection.' key: cord-018318-vzzrsqsn authors: Naidu, C. Sudeep; Sarin, Arti title: Postoperative Liver Failure date: 2017-02-08 journal: GI Surgery Annual DOI: 10.1007/978-981-10-2678-2_3 sha: doc_id: 18318 cord_uid: vzzrsqsn Technical innovations in surgical techniques, anaesthesia, critical care and a spatial understanding of the intra-hepatic anatomy of the liver, have led to an increasing number of liver resections being performed all over the world.


id: cord-032131-ghgciqfk
author: Ganschow, Rainer
title: Lebertransplantation und Leberversagen
date: 2013
extension: .txt
mime: text/plain
words: 6555
sentence: 332
flesch: 28
cache: cache/cord-032131-ghgciqfk.txt
txt: txt/cord-032131-ghgciqfk.txt
summary:
  In einer eigenen und in zwei weiteren Studien in großen pädiatrischen Zentren erwiesen sich in dem Kollektiv der Patienten mit pädiatrischem ALV neben einer ungeklärten Ätiologie, der Schwere der HE und der nierenersatztherapiepflichtigen Niereninsuffizienz nur die Höhe des Bilirubins und verschiedener plasmatischer Gerinnungsparameter (Faktor V <20 %, PTT-Verlängerung, international normalized ratio (INR) ≥4) als unabhängige Prädiktoren des Versterbens bei pädiatrischem ALV (Bhaduri u. Mieli-Vergani 1996; DeVictor et al. 1992) . Bei der Mehrzahl der Kinder kann die Steroiddosis nach der Lebertransplantation zügig reduziert werden, und spätestens nach einem Jahr kann man diese Medikation ganz absetzen.


id: cord-016880-q44623s8
author: van Hoek, B.
title: 22 Levertransplantatie
date: 2015-01-02
extension: .txt
mime: text/plain
words: 6895
sentence: 326
flesch: 49
cache: cache/cord-016880-q44623s8.txt
txt: txt/cord-016880-q44623s8.txt
summary:
  [33] j 22.3.6 Donatie bij leven is in Japan ontwikkeld, aanvankelijk als donatie van de linkerkwab van een ouder aan een kind. De oorzaak van een gallek is vaak de matige doorbloeding van het onderste deel van de ductus choledochus van de donor.


id: cord-005949-8po9xe5g
author: Streetz, K.L.
title: Akutes Leberversagen: Übersicht zur aktuellen Diagnostik und Therapie
date: 2013-11-06
extension: .txt
mime: text/plain
words: 1382
sentence: 83
flesch: 37
cache: cache/cord-005949-8po9xe5g.txt
txt: txt/cord-005949-8po9xe5g.txt
summary:
  A report from the European Liver Transplant Registry (ELTR) Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-onchronic liver failure: the RELIEF trial Population-based surveillance for acute liver failure Acute liver failure: a life-threatening disease Liver transplantation for acute liver failure in Europe: outcomes over 20 years from the ELTR database Etiologies and outcomes of acute liver failure in Germany Usefulness of corticosteroids for the treatment of severe and fulminant forms of autoimmune hepatitis Effects of fractionated plasma separation and adsorption on survival in patients with acute-on-chronic liver failure Acute liver failure: summary of a workshop Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States Development of an accurate index for predicting outcomes of patients with acute liver failure Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations Management of severe acute to fulminant hepatitis B: to treat or not to treat or when to treat? Med Klin Intensivmed Notfmed DOI: 10.1007/s00063-013-0285-4 sha: doc_id: 5949 cord_uid: 8po9xe5g Although acute liver failure is a rare disease with a prevalence of 5 per 1 million people, it has a considerablely high mortality rate of 34 %.


id: cord-340325-0oh40b6r
author: Witzigmann, Dominik
title: Lipid nanoparticle technology for therapeutic gene regulation in the liver
date: 2020-07-02
extension: .txt
mime: text/plain
words: 11255
sentence: 439
flesch: 27
cache: cache/cord-340325-0oh40b6r.txt
txt: txt/cord-340325-0oh40b6r.txt
summary:
  Impact on Physicochemical Properties, Cytokine Induction, and Efficacy Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes Synthesis and characterization of novel poly(ethylene glycol)-lipid conjugates suitable for use in drug delivery On the role of helper lipids in lipid nanoparticle formulations of siRNA Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA A combinatorial library of lipid-like materials for delivery of RNAi therapeutics Rational design of cationic lipids for siRNA delivery Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis The Onpattro® story and the clinical translation of nanomedicines containing nucleic acid-based drugs Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery The liver The Global Burden of Liver Disease: The Major Impact of China Structural and functional hepatocyte polarity and liver disease Hepatocytes: a key cell type for innate immunity Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination Elimination Pathways of Nanoparticles Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cellmediated Hepatic Antiviral Immunity Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations A human liver cell atlas reveals heterogeneity and epithelial progenitors Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis Burden of liver diseases in the world RNA-Targeted Therapeutics GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics Gene therapy comes of age Adeno-associated virus vector as a platform for gene therapy delivery mRNA vaccines-a new era in vaccinology Personalized vaccines for cancer immunotherapy Rational designs of in vivo CRISPR-Cas delivery systems Delivery Aspects of CRISPR/Cas for in Vivo Genome Editing Overcoming cellular barriers for RNA therapeutics Safety profile of RNAi nanomedicines Knocking down disease: a progress report on siRNA therapeutics Delivery of oligonucleotides with lipid nanoparticles Liposomal drug delivery systems: from concept to clinical applications Lipid Nanoparticle Systems for Enabling Gene Therapies Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Strategies, design, and chemistry in siRNA delivery systems Chemical and structural modifications of RNAi therapeutics Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles Shielding of Lipid Nanoparticles for siRNA Delivery:


id: cord-033821-i14dmmps
author: Guo, Yue-Cheng
title: Antihepatic Fibrosis Drugs in Clinical Trials
date: 2020-08-24
extension: .txt
mime: text/plain
words: 5048
sentence: 234
flesch: 35
cache: cache/cord-033821-i14dmmps.txt
txt: txt/cord-033821-i14dmmps.txt
summary:
  Thus far, liver fibrosis has been considered to be associated with a set of factors, such as viral infection, alcohol abuse, non-alcoholic fatty liver disease, and autoimmune hepatitis, as well as genetic diseases. To date, clinical therapeutics for liver fibrosis still face challenges, as elimination of potential causes and conventional antifibrotic drugs cannot alleviate fibrosis in most patients.


id: cord-022483-hdmwv540
title: Gastrointestinal Disease
date: 2009-06-05
extension: .txt
mime: text/plain
words: 19330
sentence: 983
flesch: 42
cache: cache/cord-022483-hdmwv540.txt
txt: txt/cord-022483-hdmwv540.txt
summary:
  In some respects, the diagnostic approach to colic in neonatal foals is similar to that used in mature horses: rarely will any single fact be useful in determining the exact etiology. However, early signs of abdominal pain in neonatal foals may only manifest as reduced frequency of nursing and prolonged recumbency.


id: cord-016130-5q9ufu28
author: Linday, Linda A.
date: 2010-12-17
extension: .txt
mime: text/plain
words: 11346
sentence: 369
flesch: 37
cache: cache/cord-016130-5q9ufu28.txt
txt: txt/cord-016130-5q9ufu28.txt
title:
  Nutritional Supplements and Upper Respiratory Tract Illnesses in Young Children in the United States

summary:
  The New York Times Mercury and fish oil supplements; Letter Increased mortality in children with mild vitamin A deficiency Dorland's Illustrated Medical Dictionary Vitamin A and retinoids: an update of biological aspects and clinical applications Vitamin A supplementation: implications for morbidity and mortality in children Vitamin A supplementation in infectious diseases: a meta-analysis Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis A randomized, controlled trial of vitamin A in children with severe measles Vitamin A and retinoids in antiviral responses Vitamin A, infection, and immune function Vitamin A therapy for children with respiratory syncytial virus infection: a multicenter trial in the United States Treatment of respiratory syncytial virus infection with vitamin A: a randomized Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth Dietary vitamin A intake and the risk of mortality among children Dietary vitamin A intake and the incidence of diarrhea and respiratory infection among Sudanese children Dietary vitamin A intake in relation to child growth Vitamin D analogues in insulin-dependent diabetes mellitus and other autoimmune diseases: a therapeutic perspective Comparison of the effects of 1,25-dihydroxyvitamin D3 on T lymphocyte subpopulations This chapter discusses the role of essential fatty acids, vitamins, and trace metals in the pathophysiology of inflammation; reviews our clinical research on the use of a lemon-flavored cod liver oil (which meets European purity standards) and a children's chewable multivitamin-mineral with Se for the prevention and adjunctive treatment of these disorders; reviews the history of cod liver oil, including its importance in the discovery of vitamin D and the anti-infective properties of vitamin A; and discusses the current clinical use of these supplements.


id: cord-022300-9w0lehal
author: Hoskins, Johnny D.
title: The Liver and Pancreas
date: 2009-05-15
extension: .txt
mime: text/plain
words: 12567
sentence: 565
flesch: 35
cache: cache/cord-022300-9w0lehal.txt
txt: txt/cord-022300-9w0lehal.txt
summary:
  Normal dog liver has less than 400 j.Lg copper per gram of dry tissue Twedt et al, 1979) .Affected Several different types of congenital PSS occur in young dogs and cats, including but not limited to (1) persistent patent fetal ductus venosus, (2) direct portal vein to caudal vena cava, (3) direct portal vein to azygos vein, (4) combination of portal vein with caudal vena cava into the azygos vein, (5) left gastric vein to vena caval shunt, (6) portal vein hypoplasia or atresia with secondary anomalous vessel, and (7) anomalous malformation of the caudal vena cava (Center et aI, 1995) .


id: cord-003921-8r8z0otz
author: Nakamura, Kojiro
title: The Evolving Role of Neutrophils in Liver Transplant Ischemia-Reperfusion Injury
date: 2019-01-29
extension: .txt
mime: text/plain
words: 6706
sentence: 251
flesch: 19
cache: cache/cord-003921-8r8z0otz.txt
txt: txt/cord-003921-8r8z0otz.txt
summary:
  Recombinant relaxin protects liver transplants from ischemia damage via hepatocyte glucocorticoid receptor: from bench-to-bedside Neutrophils, from marrow to microbes Sterile inflammation in the liver Intravascular danger signals guide neutrophils to sites of sterile inflammation Acetaminopheninduced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemiareperfusion injury in rat liver Efficacy of intraportal injection of anti-ICAM-1 monoclonal antibody against liver cell injury following warm ischemia in the rat Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion Thrombomodulin attenuates inflammatory damage due to liver ischemia and reperfusion injury in mice in Toll-like receptor 4-dependent manner The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection Albeit non-specifically targeting neutrophil functions, the reduction of extracellular DAMPs such as HMGB1 or histone seems favorable, because DAMPs are the immune-activating signals released from host cells but not from pathogens.


id: cord-018620-3kqx8arn
author: Rueda, Mario
title: Hepatic Failure
date: 2016-10-09
extension: .txt
mime: text/plain
words: 13815
sentence: 747
flesch: 42
cache: cache/cord-018620-3kqx8arn.txt
txt: txt/cord-018620-3kqx8arn.txt
summary:
  Besides parkinsonian movements and tremors, Kayser-Fleischer rings, psychiatric alterations, and renal problems, Wilson's disease will present with liver disease: cirrhosis, chronic failure without cirrhosis, and acute liver failure. Epidemiology of acute liver failure East meets west: acute liver failure in the global village The electroencephalograph in liver disease Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure Branched-chain amino acids in liver diseases An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons Liver function, cerebral blood flow autoregulation, and hepatic encephalopathy in fulminant hepatic failure Difficult management problems in fulminant hepatic failure Incidence and pathophysiology of pulmonary edema in fulminant hepatic failure Pulmonary vascular complications of liver disease Hepatopulmonary syndrome: role of nitric oxide and clinical aspects Hepatorenal syndrome: pathophysiology and management Hepatorenal syndrome: a dreaded complication of end-stage liver disease Coagulopathy in liver diseases Mechanisms of water and sodium retention in cirrhosis and the pathogenesis of ascites Acute liver failure Acute liver failure Risk factors and outcomes of acute kidney injury in patients with acute liver failure Diagnosis and treatment of acute renal failure in patients with cirrhosis Lactic acidosis: recognition, kinetics, and associated prognosis Lactic acidosis Too much lactate or too little liver? Intensive care management of acute liver failure Patients with acute on chronic liver failure display sepsis-like immune paralysis Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess Effects of antimicrobial prophylaxis and blood stream infections in patients with acute liver failure: a retrospective cohort study The systemic inflammatory response syndrome in acute liver failure Infection and the progression of hepatic encephalopathy in acute liver failure Jaundice in older children and adolescents Update on the treatment of the pruritus of cholestasis Acute liver failure Medical palliation of the jaundiced patient with pruritus Acute hepatitis C AASLD position paper : the management of acute liver failure : update Propofol to control intracranial pressure in fulminant hepatic failure Management of fulminant hepatic failure in the USA: results from a survey of 14 liver transplant programs The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure The American experience with transplantation for acute liver failure Ammoniainduced brain edema and intracranial hypertension in rats after portacaval anastomosis Complications of intracranial pressure monitoring in fulminant hepatic failure Cerebral and cardiovascular responses to changes in head elevation in patients with intracranial hypertension Lactulose therapy in acute liver failure Efficacy of L-ornithine L-aspartate in acute liver failure: a double-blind, randomized.


id: cord-353633-a4pu6rlu
author: Perakakis, Nikolaos
date: 2020-07-23
extension: .txt
mime: text/plain
words: 14755
sentence: 461
flesch: 21
cache: cache/cord-353633-a4pu6rlu.txt
txt: txt/cord-353633-a4pu6rlu.txt
title:
  The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

summary:
  Practice guidance from the American Association for the Study of Liver Diseases Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice Phenome-wide association studies across large population cohorts support drug target validation The dual and opposite role of the TM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non-alcoholic fatty liver disease Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis Targetedbisulfite sequence analysis of the methylation of CpG islands in genes encoding PNPLA3, SAMM50, and PARVB of patients with non-alcoholic fatty liver disease Identification of the genomic region under epigenetic regulation during non-alcoholic fatty liver disease progression Hepatic stellate cell transdifferentiation involves genome-wide remodeling of the DNA methylation landscape MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease Multigenerational epigenetic adaptation of the hepatic wound-healing response Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor gamma coactivator 1alpha promoter Identification of differentially methylated region (DMR) networks associated with progression of nonalcoholic fatty liver disease Epigenetics in non-alcoholic fatty liver disease Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model Elimination of Age-Associated Hepatic Steatosis and Correction of Aging Phenotype by Inhibition of cdk4-C/EBPalpha-p300 Axis P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts SirT1 gain of function increases energy efficiency and prevents diabetes in mice Sirt1 protects against high-fat diet-induced metabolic damage Hepatocytespecific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome Epigenetic mechanisms underlying the link between non-alcoholic fatty liver diseases and nutrition By a Candidate Genes Resequencing Strategy GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new traitassociated genes and pathways across eMERGE Network A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci Genetic determinants of steatosis and fibrosis progression in paediatric nonalcoholic fatty liver disease Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of nonalcoholic fatty liver disease associated hepatocellular carcinoma Association Between PNPLA3 rs738409 C>G Variant and Liver-Related Outcomes in Patients With Nonalcoholic Fatty Liver Disease Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with nonalcoholic fatty liver disease Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals An intronic variant in the GCKR gene is associated with multiple lipids Common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: a metaanalysis Update on NAFLD genetics: From new variants to the clinic A Pathophysiologic Approach Combining Genetics and Insulin Resistance to Predict the Severity of Nonalcoholic Fatty Liver Disease A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites Development and Validation of a Scoring System, Based on Genetic and Clinical Factors, to Determine Risk of Steatohepatitis in Asian Patients with Nonalcoholic Fatty Liver Disease Combined Effect of PNPLA3, TM6SF2, and HSD17B13 Variants on Risk of Cirrhosis and Hepatocellular Carcinoma in the General Population The diagnosis and management of nonalcoholic fatty liver disease:


id: cord-001567-3bw7jbzq
author: Borlak, Jürgen
date: 2015-02-25
extension: .txt
mime: text/plain
words: 14018
sentence: 519
flesch: 33
cache: cache/cord-001567-3bw7jbzq.txt
txt: txt/cord-001567-3bw7jbzq.txt
title:
  Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events

summary:
  Categorization of tumour regulated proteins based on ontology terms 82 non-redundant tumour proteins covering To, UR and DR categories were considered and analysed for Ontologies using the GeneXplain software (v.2.4.1), the biological pathways tools Reactome (http://www.REACTOME.org) and KEGG (http://www.genome.jp/kegg) and WikiPathways (http://wikipathways.org). It is designed to find master regulatory molecules upstream of an input list of regulated tumour proteins.


id: cord-023033-tgt69ir6
title: Poster Session (pp. 78A–178A)
date: 2006-02-10
extension: .txt
mime: text/plain
words: 16164
sentence: 723
flesch: 41
cache: cache/cord-023033-tgt69ir6.txt
txt: txt/cord-023033-tgt69ir6.txt
summary:
  Moreover, they support the hypothesis that experimental forcing of exogenous antigens into the MHC class I pathway and subsequent promotion of cross-priming is particularly important to generate T cell responses against noncytopathic and tissue tropic viruses such as HCV. For further characterization of T cell epitopes HCV specific T cell clones were generated from 6 patients against eight different HCV epitopes located within the NS3 (aa1027-1657, two epi-topes) and NS4alb (aa1658-1972, six epitopes) region.


id: cord-018414-6ffhm895
author: Kang, Yoogoo
title: Anesthesia Management of Liver Transplantation
date: 2016-07-22
extension: .txt
mime: text/plain
words: 21167
sentence: 829
flesch: 28
cache: cache/cord-018414-6ffhm895.txt
txt: txt/cord-018414-6ffhm895.txt
summary:
  Liver transplantation requires a true multidisciplinary approach, and anesthesiologists and intensivists have played a major role in the successful outcome of liver transplantation. Right ventricular function during orthotopic liver transplantation Adult respiratory distress syndrome secondary to endstage liver disease-successful outcome following liver transplantation Use of intraoperative blood salvage during orthotopic liver transplantation Compression of the brachial plexus injury during right lobe liver donation as a cause of brachial plexus injury: a case report Rapid infusion devices for hemorrhagic cardiothoracic trauma Liver transplantation: effect of washing bank blood on intraoperative control of hyperkalemia Right heart dysfunction, pulmonary embolism, and paradoxical embolization during liver transplantation.


id: cord-030369-4dn02a35
author: Peng, Liang
title: Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure)
date: 2019-05-21
extension: .txt
mime: text/plain
words: 35873
sentence: 1465
flesch: 36
cache: cache/cord-030369-4dn02a35.txt
txt: txt/cord-030369-4dn02a35.txt
summary:
  Of the possible complications occurring in liver failure patients, bleeding is the most common and severe. Concomitant infection in liver failure patients has the following characteristics: (1) a high incidence; (2) infection may occur at different sites either simultaneously or sequentially, and abdominal and biliary tract infection is the most common.


id: cord-006391-esnsa4u5
title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982
date: 1982
extension: .txt
mime: text/plain
words: 44873
sentence: 2146
flesch: 47
cache: cache/cord-006391-esnsa4u5.txt
txt: txt/cord-006391-esnsa4u5.txt
summary:
  Control patients (no ASA) were compared to those receiving 80 or 325 mg. After transplantation patients were followed for a minimum of 3 months and a maximum of 42 months.


id: cord-032181-gmcugd8h
author: Song, Jian-Xin
title: Main Complications of AECHB and Severe Hepatitis B (Liver Failure)
date: 2019-05-21
extension: .txt
mime: text/plain
words: 51195
sentence: 2228
flesch: 34
cache: cache/cord-032181-gmcugd8h.txt
txt: txt/cord-032181-gmcugd8h.txt
summary:
  If liver disease patients have other lung diseases (such as chronic bronchitis, emphysema and pneumonia, and pleural effusion, etc.), then significant respiratory symptoms may occur. in liver cirrhosis patients with ascites that paracentesis should be performed after admission to determine whether SBP exist.


id: cord-022555-a7ie82fs
title: Digestive System, Liver, and Abdominal Cavity
date: 2011-12-05
extension: .txt
mime: text/plain
words: 66503
sentence: 3320
flesch: 46
cache: cache/cord-022555-a7ie82fs.txt
txt: txt/cord-022555-a7ie82fs.txt
summary:
  The worm is transmitted to other cats that ingest the vomitus of an infected cat. Other cats should not be allowed to ingest infected vomit.


id: cord-023017-k6edtg58
title: AASLD Abstracts (pp. 282A–382A)
date: 2006-02-10
extension: .txt
mime: text/plain
words: 65964
sentence: 2936
flesch: 47
cache: cache/cord-023017-k6edtg58.txt
txt: txt/cord-023017-k6edtg58.txt
summary:
  The aim of the present study was to investigate if the same inhibition takes place in livers cells of patients with chronic hepatitis C. From February 2001 to April 2002, all patients with chronic hepatitis C referred to the outpatient liver clinic of the University Hospital Basel were asked for their permission to use part of the liver biopsy for this study. Increased T cell activation with Eta may also suggest that TNFA suppress T cell function and may contribute to refractoriness to INF therapy in HCV patients.


id: cord-022754-ehq9qnoo
title: Liver
date: 2012-07-25
extension: .txt
mime: text/plain
words: 87936
sentence: 4382
flesch: 36
cache: cache/cord-022754-ehq9qnoo.txt
txt: txt/cord-022754-ehq9qnoo.txt
summary:
  Fad or future of liver disease? Copper-induced hepatitis: the COMMD1 deficient dog as a translational animal model for human chronic hepatitis Copper-associated liver disease Esteller A: Physiology of bile secretion Coagulation disorders in dogs with hepatic disease Current cytochrome P450 phenotyping methods applied to metabolic drug-drug interaction prediction in dogs Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes P50 Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse Cytochrome P450s and other enzymes in drug metabolism and toxicity mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates Modulation of acetaminopheninduced hepatotoxicity by the xenobiotic receptor CAR Increased free cortisol in plasma of dogs with portosystemic encephalopathy Chronic glucocorticoid excess and impaired osmoregulation of vasopressin release in dogs with hepatic encephalopathy GABAergic inhibition of the pituitary release of adrenocorticotropin and melanotropin is impaired in dogs with hepatic encephalopathy Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell Characterisation of 11 beta-hydroxysteroid dehydrogenases in feline kidney and liver Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone Feline lower urinary tract diseases Metabolic and genetic aspects of urate urolithiasis in Dalmatians Hypoglycemia associated with nonislet cell tumor in 13 dogs The origins and kinetics of bilirubin in dogs with hepatobiliary and haemolytic diseases Bilirubin metabolism in canine hepatobiliary and haemolytic disease Plasma coagulation factor abnormalities in dogs with naturally occurring hepatic disease Alterations of prothrombin time and activated partial thromboplastin time id dogs with hepatic disease Correlation between coagulation profile findings and bleeding complications after ultrasoundguided biopsies: 434 cases (1993-1996) Use of a test for proteins induced by vitamin K absence or antagonism in diagnosis or anticoagulant poisoning in dogs HP: Circulatory disorders of the liver in dogs and cats Diagnostic value of fasting plasma ammonia and bile acid concentrations in identification of portosystemic shunting in dogs Evaluation of ammonia measurements in dogs with two analysers for use in veterinary practice Ultrasonographic findings in dogs with hyperammonemia: 90 cases Comparative studies on plasma and tissue sorbitol, glutamic, lactic and hydroxybutyric dehydrogenase and transaminase activities in the dog Pharmacokinetics of liver transaminases in healthy dogs: potential clinical relevance for assessment of liver damage Plasma and tissue enzyme activities in the cat Hepatic clearance of rat liver aspartate aminotransferase isozymes: evidence for endocytotic uptake via different binding sites on sinusoidal liver cells Effects of phenobarbital treatment on serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs Lobular dissecting hepatitis in juvenile and young adult dogs Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman Pinschers Chronic active hepatitis in 26 Doberman Pinschers Improvement in liver pathology after 4 months of D-penicillamine in 5 Doberman Pinschers with subclinical hepatitis Subclinical versus clinical hepatitis in the Doberman: Evaluation of changes in blood parameters Copper-associated hepatopathies in dogs Hepatitis and copper accumulation in Skye Terriers Part I. Differential diagnosis Glomerular filtration rate and renal volume in dogs with congenital portosystemic vascular anomalies before and after surgical ligation Morphology of congenital portocaval shunts in dogs and cats Congenital interruption of the portal vein and caudal vena cava in dogs: six case reports and a review of the literature Functional closure of the ductus venosus during early postnatal life in the dog The anatomy and embryology of portosystemic shunts in dogs and cats Portal hypertension associated with primary hypoplasia of the hepatic portal vein in dogs Budd-Chiari syndrome) as a cause of ascites in a cat Use of endovascular stents in three dogs with Budd-Chiari syndrome Characterization of hepatoportal microvascular dysplasia in a kindred of cairn terriers Ultrasonographic identification and characterization of congenital portosystemic shunts and portal hypertensive disorders in dogs and cats Gross anatomy of the canine portal vein Portal hypertension Part I. Pathophysiology and clinical consequences Ultrasonographic evaluation of partially attenuated congenital extrahepatic portosystemic shunts in 14 dogs Polycystic kidney and liver disease in cats Acquired portosystemic shunting in 2 cats secondary to congenital hepatic fibrosis Portal hypertension in a dog due to circumscribed fibrosis of the wall of the extrahepatic portal vein Ultrasonographic diagnosis of unusual portal vascular abnormalities in two cats Thrombosis of the portal vein in eleven dogs Heterobilharzia americana infection in a dog Multiple congenital portal vein anomalies in a dog Intraoperative ultrasonography of the portal vein during attenuation of intrahepatic portocaval shunts in dogs Portosystemic communications in the dog Nutritional aspects of the management of chronic hepatic encephalopathy Alterations of GABA-A and dopamine D-2 brain receptors in dogs with portal-systemic encephalopathy Clinical presentation and management of moxidectin toxicity in two dogs Generalized motor seizures after portosystemic shunt ligation in dogs: five cases Nutritional support for dogs and cats with hepatobiliary disease Effects of a branched chain amino acid-enriched diet on chronic hepatic encephalopathy in dogs Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts Evaluation of twelve-hour preprandial and two-hour postprandial serum bile acids disease in dogs Hematologic changes associated with serum and hepatic iron alterations in dogs with congenital portosystemic vascular anomalies Characterization of iron status in young dogs with portosystemic shunt Iron status and erythrocyte volume in dogs with congenital portosystemic vascular anomalies Hemostatic profiles in 39 dogs with congenital portosystemic shunts Coagulation profiles in dogs with congenital portosystemic shunts before and after surgical attenuation Standard planes for ultrasonographic examination of the portal system in dogs Szatmári V: Ultrasonography of portosystemic shunting in dogs Doppler studies before, during and after surgery Ultrasonographic assessment of hemodynamic changes in the portal vein during surgical attenuation of congenital extrahepatic portosystemic shunts in dogs Use of transcolonic 99mtechnetium-pertechnetate as a screening test for portosystemic shunts in dogs Quantification of portosystemic shunting in dogs by ultrasound-guided injection of 99m Tc-macroaggregates into a splenic vein Portal vein anomalies in the dog: their angiographic diagnosis Use of intraoperative mesenteric portovenography in congenital portosystemic shunt surgery Helical computed tomographic angiography of canine portosystemic shunts Three-dimensional multiscale helical computed tomography techniques for canine extra-hepatic portosystemic shunt assessment Use of magnetic resonance angiography for diagnosis of portosystemic shunts in dogs Brain magnetic resonance imaging characteristics in dogs and cats with congenital portosystemic shunts Medical management of animals with portosystemic shunts Improvement of chronic hepatic encephalopathy in dogs by the benzodiazepine-receptor partial inverse agonist sarmazenil, but not by the antagonist flumazenil Apparent dietary protein requirement of dogs with portosystemic shunt Medical management of congenital portosystemic shunts in 27 dogs -a retrospective study Ultrasonographic diagnosis of congenital portosystemic shunt in 14 cats Increasing incidence of hereditary intrahepatic portosystemic shunts in Irish Wolfhounds in the Netherlands (1984 to 1992) Determination of inheritance of single congenital portosystemic shunts in Yorkshire Terriers Inherited congenital extrahepatic portosystemic shunts in cairn terriers Detection of the single nucleotide polymorphism causing feline autosomal-dominant polycystic kidney disease in Persians from the UK using a novel real-time PCR assay Diagnostic value of fasting plasma ammonia and plasma bile acid concentrations in the identification of portosystemic shunting in dogs Hyperammonemia due to a urea cycle enzyme deficiency A suspected case of ornithine transcarbamylase deficiency in a cat Transient metabolic hyperammonaemia in young Irish Wolfhounds Hyperammonemia associated with urethral obstruction in a dog Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine Cobalamin deficiency associated with methylmalonic acidemia in a cat Hyperammonaemic encephalopathy secondary to selective cobalamin deficiency in a juvenile Border collie Transient hyperammonemia in an adult German Shepherd dog Evaluation of bile acid concentrations for the diagnosis of portosystemic venous anomalies in the dog and cat Epidemiologic factors associated with the anatomic location of intrahepatic portosystemic shunts in dogs Association of breed with the diagnosis of congenital portosystemic shunts in dogs: 2400 cases Ammonia tolerance test in clinically normal dogs and in dogs with portosystemic shunts Rectal ammonia tolerance test in the evaluation of portal circulation in dogs with liver disease Postprandial venous ammonia concentration in the diagnosis of hepatobiliary disease in dogs Long-term biochemical and physiologic effects of surgically placed portocaval shunts in dogs Outcome of ameroid constrictor occlusion of single congenital extrahepatic portosystemic shunts in cats: 12 cases Evaluation of ameroid ring constrictors for the management of single extrahepatic portosystemic shunts in cats: 23 cases Clinicopathologic features of primary and metastatic neoplastic disease of the liver in dogs A retrospective study of 395 feline neoplasms A survey of feline neoplasms Hepatobiliary neoplasia in dogs and cats Tumors of the liver and gallbladder Small Animal Clinical Oncology Primary neoplasms in dog liver induced by diethylnitrosamine Translation of new cancer treatments from pet dogs to humans The establishment and characterization of the first canine hepatocellular carcinoma cell line, which resembles human oncogenic expression patterns Immunohistochemical characterization of canine hyperplastic hepatic lesions and hepatocellular and biliary neoplasms with monoclonal antibody hepatocyte paraffin 1 and a monoclonal antibody to cytokeratin 7 Canine hepatic neuroendocrine carcinoma: an immunohistochemical and electron microscopic study Canine biliary carcinoma: epidemiological comparisons with man Comparative analysis of hepatocellular carcinoma in men and dogs Inactivation of TGFbeta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection Epidermal growth factor-induced hepatocellular carcinoma: gene expression profiles in precursor lesions, early stage and solitary tumours Identification of hepatic stem/progenitor cells in canine hepatocellular and cholangiocellular carcinoma Withrow and MacEwen's Small Animal Clinical Oncology Status epilepticus after ligation of portosystemic shunts Progressive remission of portosystemic shunting in 23 dogs after partial closure of congenital portosystemic shunts Gradual occlusion of extrahepatic portosystemic shunts in dogs and cats using the ameroid constrictor Methods of gradual vascular occlusion and their applications in treatment of congenital portosystemic shunts in dogs: a review A method for controlling portal pressure after attenuation of intrahepatic portocaval shunts Gauged attenuation of congenital portosystemic shunts: results in 160 dogs and 15 cats Evaluation of cellophane banding with and without intraoperative attenuation for treatment of congenital extrahepatic portosystemic shunts in dogs Cellophane banding for the gradual attenuation of single extrahepatic portosystemic shunts in eleven dogs Outcomes of cellophane banding for congenital portosystemic shunts in 106 dogs and 5 cats Evaluation of the characteristics of venous occlusion after placement of an ameroid constrictor in dogs Evaluation of ameroid ring constrictors for treatment for single extrahepatic portosystemic shunts in dogs: 168 cases Evaluation of a portocaval venograft and ameroid ring for the occlusion of intrahepatic portocaval shunts in dogs Surgical management of left divisional intrahepatic portosystemic shunts: outcome after partial ligation of, or ameroid ring constrictor placement on, the left hepatic vein in twenty-eight dogs Laparoscopic portosystemic shunt attenuation in two dogs Transvenous coil embolization of portosystemic shunt in dogs Transjugular coil embolisation of an intrahepatic shunt in a cat Complications associated with the diagnostic, medical, and surgical management of portosystemic shunts Portal vein thrombosis as a complication of portosystemic shunt ligation in two dogs Neurologic dysfunction in dogs following attenuation of congenital extrahepatic portosystemic shunts Neurologic dysfunction in three dogs and one cat following attenuation of intrahepatic portosystemic shunts Use of propofol to manage seizure activity after surgical treatment of portosystemic shunts Portal hypertension Part II: Clinical assessment and treatment Diagnostic comparison of needle and wedge biopsy specimens of the liver in dogs and cats Magnetic resonance imaging of focal splenic and hepatic lesions in the dog Accuracy of ultrasound guided aspiration of the liver and cytologic findings in dogs and cats: 97 cases A multistep approach in the cytologic evaluation of liver biopsy samples of dogs with hepatic diseases Metronomic therapy with cyclophosphamide and piroxicam effectively delays tumor recurrence in dogs with incompletely resected soft tissue sarcomas Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature Sorafenib in advanced hepatocellular carcinoma: we have won a battle not the war Phase I dose escalating study of SU11654, a small molecule receptor tyrosine kinase inhibitor, in dogs with spontaneous malignancies Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: the M.D. Anderson experience Percutaneous arterial embolization and chemoembolization for treatment of benign and malignant tumors in three dogs and a goat Treatment of unresectable hepatocellular adenoma in dogs with transarterial iodized oil and chemotherapy with and without an embolic agent: a report of two cases Results of partial hepatectomy in 18 dogs with hepatocellular carcinoma The pathology of liver tumours in the dog Partial hepatectomy in dogs Cancer of the liver Efficacy of mitoxantrone against various neoplasms in dogs Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?


id: cord-000083-3p81yr4n
title: Poster Exhibition
date: 2009-01-31
extension: .txt
mime: text/plain
words: 113010
sentence: 5582
flesch: 51
cache: cache/cord-000083-3p81yr4n.txt
txt: txt/cord-000083-3p81yr4n.txt
summary:
  From this group of HBV patients 35 (98%) have had elevated urinal Dol excreation (45,8±5,2 g/ml vs . 3% and 47.4 respectively in HCC patients, 60.3% and 39.7 in LC patients, 55% and 40 in CHB patients, 55% and 40 in ACLF patients.


# url

id: cord-018318-vzzrsqsn
domain: www.uptodate.com
url:
  www.uptodate.com/contents/hepatotoxicity-due-to-herbal-medications-anddietary-supplements?source=search_result&search=hepatotoxicity+due+to+herbal+medications


# ent

id: cord-005949-8po9xe5g
sid: 8
eid: 4
type: PERSON
entity:
  rascher entwicklung einer hepatischen enzephalopathie ohne vorliegen eines chronischen leberschadens definiert


id: cord-005949-8po9xe5g
sid: 9
eid: 2
type: ORG
entity:
  zeit zwischen dem auftreten von koagulopathie und beginnender hepatischer enzephalopathie weiterhin zwischen dem hyperakuten


id: cord-005949-8po9xe5g
sid: 31
eid: 1
type: PERSON
entity:
  eine begleitende plättchendysfunktion und thrombopenie führt dann zu klinisch vermehrter blutungsneigung


id: cord-005949-8po9xe5g
sid: 32
eid: 1
type: ORG
entity:
  der ausfall der hepatischen entgiftungsfunktion geht mit einem messbaren anstieg des bilirubins und des ammoniaks einher


id: cord-032131-ghgciqfk
sid: 24
eid: 3
type: ORG
entity:
  prolongatus mit einer hyperbilirubinämie durch direktes bilirubin sowie acholischen stühlen und gedeihstörung auf.


id: cord-032131-ghgciqfk
sid: 65
eid: 1
type: PERSON
entity:
  dieser antiproliferative effekt kann gewisse vorteile bei der therapie von transplantationspatienten mit malignen erkrankungen


id: cord-032131-ghgciqfk
sid: 79
eid: 4
type: ORG
entity:
  der medizinischen ausgangssituation des organempfängers sowie der guten interdisziplinären zusammenarbeit


id: cord-032131-ghgciqfk
sid: 94
eid: 2
type: PERSON
entity:
  der mütterlich übertragenen cmvspezifischen antikörper beim säugling mit risikokonstellation sowie zentrumspezifisch wird eine cmv-prophylaxe


id: cord-032131-ghgciqfk
sid: 108
eid: 1
type: PERSON
entity:
  therapeutisch stehen neben der reduktion der immunsuppression bei ptld auch anti-cd20-antikörper zur verfügung


id: cord-032131-ghgciqfk
sid: 124
eid: 1
type: PERSON
entity:
  neben der somatischen entwicklung nach lebertransplantation sind auch die kognitive entwicklung sowie die lebensqualität der


id: cord-032131-ghgciqfk
sid: 146
eid: 2
type: ORG
entity:
  individualisierung der protokolle zur immunsuppression nach pädiatrischer lebertransplantation werden.


id: cord-032131-ghgciqfk
sid: 157
eid: 3
type: ORG
entity:
  dass durch eine höhere bereitschaft zur organspende und vielleicht auch durch einen weiteren ausbau der leberlebendspende zwischen erwachsenen dem aktuell noch


id: cord-032131-ghgciqfk
sid: 191
eid: 1
type: ORG
entity:
  den letzten jahren nehmen nichtparacetamolinduzierte idiosynkratische medikamentenverursachte alv zu


id: cord-032131-ghgciqfk
sid: 207
eid: 1
type: ORG
entity:
  wird eine aplastische anämie bei dieser ätiologie auch nach erfolgreicher pädiatrischer lebertransplantation sowie im


id: cord-032131-ghgciqfk
sid: 262
eid: 1
type: ORG
entity:
  deren effektivität (noch) nicht nachgewiesen ist, empfehlen wir generell auch hier einen therapieversuch


id: cord-032131-ghgciqfk
sid: 291
eid: 2
type: ORG
entity:
  den letzten 15 jahren als etablierte standardtherapie auch bei pädiatrischem alv bezeichnet werden und sollte prinzipiell bei allen hiervon betroffenen


id: cord-018318-vzzrsqsn
sid: 403
eid: 1
type: ORG
entity:
  www.uptodate.com/contents/hepatotoxicity-due-to-herbal-medications-anddietary-supplements?source=search_result&search=hepatotoxicity+due+to+herbal+medications &


