item: #1 of 105 id: cord-000137-idffrnac author: Xiang, Meng title: Pattern Recognition Receptor–Dependent Mechanisms of Acute Lung Injury date: 2009-11-02 words: 9140 flesch: 28 summary: The PI3K/Akt pathway was also reported to be involved in TLR4-induced expression of IL-1β, TNF-α and chemokine macro phage inflammatory protein (MIP)-2 (78) . What we have learned from small interfering RNAs Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants Toll-like receptors in normal and cystic fibrosis airway epithelial cells Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4-and NF-kappaB-dependent mechanism Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4 DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch Diffusible signal to murine alveolar macrophages from lipopolysaccharideand Escherichia coli-stimulated lung Type II epithelial cells Enhancement of TLR-mediated innate immune responses by peptidoglycans through NOD signaling Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo TLR signaling in the gut in health and disease Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis Systemic inflammation and remote organ injury following trauma require HMGB1 Toll-like receptors as targets in chronic liver diseases Evolving concepts in the pathogenesis of postinjury multiple organ failure Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS NF-kappa B and STAT5 play important roles in the regulation of mouse Tolllike receptor 2 gene expression HMGB1 as a late mediator of lethal systemic inflammation Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62 Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2 HMGB-1 as a late mediator of endotoxin lethality in mice Reversing established sepsis with antagonists of endogenous highmobility group box 1 The danger model: a renewed sense of self Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses Addicted to death: invasive cancer and the immune response to unscheduled cell death HMGB1 contributes to the development of acute lung injury after hemorrhage Hepatic ischemia/ reperfusion injury involves functional TLR4 signaling in nonparenchymal cells Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock Regulation of lung injury and repair by Toll-like receptors and hyaluronan Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4 Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. keywords: acid; activated; activation; activity; acute; adaptor; airway; alveolar; amφ; apoptosis; bacterial; binding; card; cblb; cd14; cd44; cells; chemokine; complex; critical; cytokines; damage; dependent; development; different; disease; distress; dna; domain; ecs; endogenous; endothelial; enhanced; epithelial; essential; expression; factor; family; following; function; gene; gram; hmgb1; human; il-1β; immune; immunity; important; induced; infection; inflammasome; inflammation; inflammatory; inhibitor; injury; innate; interactions; kinase; ligands; like; like receptor; lipopolysaccharide; lps; lung; lung injury; macrophages; major; mda5; mechanism; mice; migration; model; molecular; molecules; myd88; nad(p)h; nalp3; negative; neutrophil; nlrs; nod1; nod2; organ; oxidase; pathway; patients; pmn; polymorphisms; positive; present; protein; prrs; pulmonary; recent; receptor; recognition; recruitment; regulation; release; respiratory; response; results; rig; rna; role; sepsis; shock; signaling; studies; study; surface; syndrome; system; terminal; tir; tissue; tlr2; tlr3; tlr4; tlrs; toll; trif; turn; type; virus; vivo cache: cord-000137-idffrnac.txt plain text: cord-000137-idffrnac.txt item: #2 of 105 id: cord-000217-chd9ezba author: Anas, Adam title: Role of CD14 in lung inflammation and infection date: 2010-03-09 words: 5603 flesch: 38 summary: However, when a high dose of LPS was administered to the lungs of mice, acute lung infl ammation was absent in mice lacking functional TLR4, but only partially reduced in CD14 defi cient mice [24] . Interestingly, despite impaired bacterial clearance in CD14-defi cient and TLR4-defi cient mice, the infl ammatory response in the lung was strongly reduced in TLR4 defi cient mice, but elevated in CD14 defi cient mice. keywords: activation; alveolar; ammation; ammatory; anti; bacterial; binding; cause; cd14; cells; cient; cient mice; clearance; coli; defense; defi; dependent; eff; ese; essential; expression; factor; gram; host; immune; infection; infi; infl; innate; lbp; like; lipopolysaccharide; lps; lta; lung; macrophages; md-2; mice; myd88; ndings; negative; neutrophil; pattern; peptidoglycan; pneumonia; protein; pulmonary; receptor; recognition; reduced; release; respiratory; response; role; rough; secretion; smooth; surface; tlr2; tlr4; tnf; toll; tuberculosis; type; uenzae; virus cache: cord-000217-chd9ezba.txt plain text: cord-000217-chd9ezba.txt item: #3 of 105 id: cord-000425-isw6jeir author: Flori, Laurence title: Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation date: 2011-07-29 words: 7843 flesch: 40 summary: This cluster is representative of total cell number traits despite the eosinophil count (EOS) not being included. The estimation of phenotypic correlations (r r p ) with WOMBAT confirmed that the ITs are weakly correlated, except i) among a few cell count traits (WBC, LYM, MON, NEU), and ii) between cell count traits and a few leukocyte subsets (WBC, LYM, CD16 + CD2 + and keywords: acute; adaptive; animals; antibodies; antibody; blood; cd16; cd172a; cd4; cell; cluster; cona; control; correlations; count; crp; cytokines; data; different; diluted; effects; elisa; equal; estimates; figure; france; genetic; health; heritability; heritable; high; higher; humoral; hyopneumoniae; igg; il10; il12; il2; il6; il8; immune; immunity; immunocompetence; infection; innate; ionomycin; isotype; large; leukocyte; levels; low; lps; lymphocytes; measured; mhcii; model; moderate; number; parameters; pathogens; pca; phagocytosis; phase; phenotypic; pigs; pmaiono; production; proliferation; resistance; response; results; samples; selection; serum; sigma; software; specific; stimulation; studies; study; subsets; swine; table; test; time; tnf; total; traits; use; vaccination; values; variance; variation; volume; wbc; weak; white cache: cord-000425-isw6jeir.txt plain text: cord-000425-isw6jeir.txt item: #4 of 105 id: cord-000460-h3owwjao author: Xiong, Jing title: Leukocyte- and Platelet-Derived Microvesicle Interactions following In Vitro and In Vivo Activation of Toll-Like Receptor 4 by Lipopolysaccharide date: 2011-09-26 words: 4328 flesch: 34 summary: While those experiments provide evidence that LPS modulates platelet activation, they do not provide any insight about the interactions of platelet with other blood elements within the earliest stages of activation especially at time points prior to the period when measurable changes in circulating cytokines are observed in vivo For example, MV derived from neutrophils induced platelet activation by binding to platelets GP1ba (Glycoprotein 1b a) via activated a M b 2 on MV [38] , while platelet-derived MV mediate leukocyte-leukocyte aggregation, activate leukocyte phagocytic properties and amplify leukocyte-mediated tissue injury in thrombotic and inflammatory disorders [39] . keywords: activation; acute; aggregates; analysis; antibodies; antigen; blood; cardiovascular; cd41; cd45; cell; cellular; control; cytometry; days; dependent; diluted; events; exposure; expression; figure; flow; half; hour; infection; interactions; leukocyte; life; like; lipopolysaccharide; lps; membrane; mice; microparticles; min; monocytes; mouse; myd88; number; platelet; positive; present; production; receptor; results; risk; sentinel; signaling; single; specific; stimulation; study; surface; time; tlr4; toll; trif; vehicle; vivo cache: cord-000460-h3owwjao.txt plain text: cord-000460-h3owwjao.txt item: #5 of 105 id: cord-000920-68eblcke author: Gallego, Carolina title: Interaction of Bordetella bronchiseptica and Its Lipopolysaccharide with In Vitro Culture of Respiratory Nasal Epithelium date: 2013-03-11 words: 4568 flesch: 34 summary: The specific reaction of B. bronchiseptica LPS with lectin histochemistry was found mostly within goblet cell cytoplasm (Figure 2(c) ); controls did not show a similar reaction. [56] documented TLR4 activation by B. bronchiseptica LPS and they noted its importance for PMN recruitment and cytokine production. keywords: activity; adherence; antiserum; bacteria; bacterium; bordetella; bordetella bronchiseptica; bronchiseptica; cells; cellular; changes; ciliated; colonization; control; culture; cytoplasmic; death; different; documented; dogs; early; effects; epithelial cells; epithelium; experimental; expression; fetal; figure; goblet; histochemistry; host; hours; human; iii; iip; infection; infiltration; interaction; lectin; lesions; lipopolysaccharide; lps; lumen; metaplasia; mice; min; mucus; multocida; mycobacterium; nasal; negative; number; pasteurella; pathogen; pigs; pmn; pss; rabbits; respiratory; respiratory epithelium; secretion; septa; septum; similar; study; test; tissue; tract; type; vacuolation; work cache: cord-000920-68eblcke.txt plain text: cord-000920-68eblcke.txt item: #6 of 105 id: cord-000959-nk2thkme author: Downer, Eric J. title: Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory date: 2013-05-06 words: 5417 flesch: 43 summary: [30] and T cell memory TLR4 expression on CD11b + PBMCs was similar in HP and LP groups and this is also shown in the representative dot plots of TLR4 + cells (O) which indicate the percentage positive cells. keywords: activated; activation; adhesion; alzheimer; amyloid; analysis; anti; blood; brain; cd11b; cd14; cdna; cells; central; changes; cns; cognitive; cohort; conditions; consistent; cytokine; data; discrepant; disease; display; enhanced; expression; figure; flow; function; gene; greater; group; human; il-6; immune; individuals; infection; inflammatory; innate; levels; like; lp group; lps; macrophages; mdms; mean; memory; microglia; monocytes; mrna; neurodegenerative; p,0.05; participants; pbmcs; percentage; peripheral; phenotype; plasma; plots; positive; prepared; production; receptor; relative; representative; response; samples; similar; study; system; test; tlr2; tlr4; tlrs; toll; treatment cache: cord-000959-nk2thkme.txt plain text: cord-000959-nk2thkme.txt item: #7 of 105 id: cord-000984-64p3wpav author: Huang, Shang-Hui title: Self-Oligomerization Is Essential for Enhanced Immunological Activities of Soluble Recombinant Calreticulin date: 2013-06-10 words: 5265 flesch: 46 summary: Samples of the eluted fractions were assayed by SDS-PAGE (Fig. 1A) , which showed that the eluent between 360-380 mM NaCl contained protein bands of the expected molecular weight for nCRT (55 kDa), which showed approximately 90% homogeneity judging by density of the major band in Coomassie blue (CBB)-stained gel (Fig. 1C ). In our previous study, rCRT/39-272 could effectively activate mouse macrophages in vitro keywords: 37uc; able; abs; activation; active; activities; activity; analysis; anti; binding; buffer; calreticulin; cells; chaperone; column; concentration; cp32; crt; domain; fig; figs; fitc; form; gel; higher; human; hypothesis; ias; igg; immune; immunization; immunological; kda; lectin; lps; macrophages; mice; min; molecular; monomeric; motif; mouse; nacl; ncrt; oligomerization; oligomers; orcrts; page; pbs; polypeptides; potent; production; protein; rabbit; rcrt/120; rcrt/18; rcrt/39; recombinant; residues; responses; results; sds; self; sequence; site; soluble; strong; surface; type; usa; weight cache: cord-000984-64p3wpav.txt plain text: cord-000984-64p3wpav.txt item: #8 of 105 id: cord-001496-186k6t03 author: Yuan, Qing title: Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats date: 2014-12-05 words: 5028 flesch: 40 summary: In contrast, in LPS plus Ginsenoside Rb1 group the level was significantly decreased to almost the same as that of the Control group ( Figure 4B ). Lung injury was assessed by pulmonary histology, lung wet-weight to dry-weight (W/D) ratio, the number of myeloperoxidase (MPO) positive cells, immunohistochemical analysis of intercellular adhesion molecule-1 (ICAM-1), gene expression of ICAM-1, ultrastructure changes of pulmonary microvasculature, concentration of inflammatory markers and in plasma. keywords: actin; activation; acute; adhesion; ali; analysis; animals; anti; blood; cells; control; cytokines; edema; effect; endothelial; expression; factor; figure; gene; ginsenoside; ginsenoside rb1; group; il-8; infiltration; inflammation; inflammatory; infusion; injection; injury; intercellular; leukocytes; level; lipopolysaccharide; lps; lps group; lung; lung injury; mcp-1; microvascular; mins; molecules; mpo; mrna; neutrophil; p65; plasma; pmvecs; positive; present; pulmonary; rabbit; rat; ratio; rats; rb1; results; saline; staining; study; tissue; tnf; treatment; usa; vitro; κb p65 cache: cord-001496-186k6t03.txt plain text: cord-001496-186k6t03.txt item: #9 of 105 id: cord-001569-jd028cyg author: dos Santos, Gimena title: Vimentin regulates activation of the NLRP3 inflammasome date: 2015-03-12 words: 8486 flesch: 42 summary: Our data obtained in vimentin knockout mice and vimentin-null cells suggest that vimentin is required for NLRP3 inflammasome activation. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require NLRP3 inflammasome activation. keywords: activation; active; acute; administration; afm; ali; alveolar; analysis; animals; asbestos; asc; assay; assembly; atp; balf; binding; biosensor; bleomycin; bone; caspase-1; cells; collagen; complex; compliance; components; control; cytokine; data; days; deficient; deposition; disease; dose; elastic; experiments; exposure; fibrosis; fig; filaments; fluid; following; group; human; il-1b; immune; increase; inflammasome; inflammasome activation; inflammation; inflammatory; injury; interaction; intermediate; levels; localization; lps; lung; lysates; macrophages; marrow; maturation; mature; measurements; mice; microscopy; models; modulus; mouse; msu; nlrp3; nlrp3 inflammasome; northwestern; pbs; production; protein; pulmonary; reduced; regions; response; results; rna; role; saline; signalling; significant; sircol; staining; step; supplementary; supplementary fig; test; tgf; time; tissue; total; treatment; type; university; vim; vimentin; weight; wild; wt mice cache: cord-001569-jd028cyg.txt plain text: cord-001569-jd028cyg.txt item: #10 of 105 id: cord-002079-jne14jqf author: MacParland, Sonya A. title: Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression date: 2016-05-27 words: 7212 flesch: 38 summary: We suspect that whereas increased TNF-␣ does contribute to USP18 expression, there are other stimuli, for example, LPS and perhaps the recently described interferon-lambda 4 (56) , that also modulate hepatic USP18 expression. Hepatic ischemia/reperfusion injury led to an induction of USP18 expression in liver tissue and promotion of lymphocytic choriomeningitis replication. keywords: ability; activation; alpha; anti; cells; chronic; control; data; effect; expression; factor; fig; findings; forward; gene; hcv; hepatic; hepatitis; hepatocytes; hiri; huh7.5; ifn-; il-10; il-6; immune; induction; infection; inflammation; inflammatory; inhibitor; injury; innate; interferon; ischemia; isg15; isgs; kinase; knockdown; lcmv; liver; lps; mice; min; mouse; mrna; multiple; murine; mx1; primary; primer; protein; reperfusion; replication; response; reverse; role; signaling; silibinin; sirna; specific; stimulation; stimuli; study; target; therapy; time; tissue; tnf-; treatment; type; ube1l; usp18; usp18 expression; viral; virus; vivo cache: cord-002079-jne14jqf.txt plain text: cord-002079-jne14jqf.txt item: #11 of 105 id: cord-002165-blbaqbo7 author: Wu, Dongdong title: Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung Injury in Mice date: 2016-08-15 words: 4768 flesch: 44 summary: IRF-1 KO mice were used to investigate whether IRF-1 mediates LPS-induced acute lung injury and cytokine release. IRF-1 KO mice demonstrated significantly improved 96-h survival rates compared with the control WT mice (P <0.05). keywords: activation; activity; acute; ali; alveolar; ams; analysis; antibody; ards; asc; associated; atp; balf; caspase-1; cells; control; cytokine; death; dependent; determined; expression; factor; fig; group; hmgb1; il-1b; induced; inflammation; inflammatory; injury; interferon; irf-1; j744.a1; key; ldh; levels; like; lps; lung; macrophages; mediates; mice; min; mouse; nuclear; overexpression; pbs; presence; protein; pyroptosis; regulatory; release; role; shrna; signaling; study; temperature; tissue; tlr4; total; western cache: cord-002165-blbaqbo7.txt plain text: cord-002165-blbaqbo7.txt item: #12 of 105 id: cord-002411-iiw878w8 author: Ding, Xibing title: TLR4 signaling induces TLR3 up-regulation in alveolar macrophages during acute lung injury date: 2017-02-15 words: 6685 flesch: 47 summary: 1C , a 1 μ g/ml LPS challenge of AMΦ from WT mice was associated with an increase in TLR3 protein expression at 4 h and a more marked increase at 6 h, while the increase in TLR3 expression trended back to the basal level at 8 h. The TLR3 mRNA expression changes shown in Fig. Actin expression was identified to normalize the densitometry of TLR3 expression. keywords: activation; acute; alveolar; amplification; amφ; analysis; animals; antibody; bacterial; balf; cells; challenge; changes; chemokines; cross; cytokines; dependent; eba; expression; fig; following; group; il-6; immune; important; increase; induced; infections; inflammation; inflammatory; injury; ligand; like; lps; lung; macrophage; mice; migration; mip-2; mouse; mrna; myd88; observed; pbs; pcr; pmn; poly; protein; receptor; regulation; response; results; role; sal; saline; sequential; signaling; studies; study; talk; time; tissue; tlr3; tlr3 expression; tlr4; tnf; toll; viral; −/− cache: cord-002411-iiw878w8.txt plain text: cord-002411-iiw878w8.txt item: #13 of 105 id: cord-003055-88q36g00 author: Imai, Kenji title: Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model date: 2018-06-15 words: 6223 flesch: 35 summary: The pregnant mice were assigned randomly to three groups of five dams each: Control group, LPS group, and HW + LPS group (Fig. 6) , as in our previous report 12 . The association between maternal immune activation (MIA) and subsequent neurodevelopmental disorders in offspring has become increasingly recognized, with both epidemiological evidence and research findings in various animal models [1] [2] keywords: abnormalities; activation; administration; amygdala; animal; asd; astrocytes; autism; behavioral; brain; cells; cerebral; chamber; control; cortex; cytokines; damage; deficits; development; disorders; effect; exposure; expression; fetal; fig; following; gating; gfap; group; h(2; hippocampus; hydrogen; il-6; immune; impairments; inflammation; inflammatory; injury; life; like; lipopolysaccharide; loss; lps; lps group; maternal; matter; maze; medium; memory; mia; mice; microglia; model; molecular; mouse; neonatal; neuronal; neurons; novelty; number; offspring; olig2; oligodendrocytes; positive; postnatal; ppi; preference; prenatal; present; previous; primary; pro; results; schizophrenia; sensorimotor; short; sociability; social; startle; stranger; study; term; test; treatment; weeks; white cache: cord-003055-88q36g00.txt plain text: cord-003055-88q36g00.txt item: #14 of 105 id: cord-003099-a0acr28o author: Koch, R. M. title: The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection date: 2018-07-05 words: 3886 flesch: 34 summary: key: cord-003099-a0acr28o authors: Koch, R. M.; Diavatopoulos, D. A.; Ferwerda, G.; Pickkers, P.; de Jonge, M. I.; Kox, M. title: The endotoxin-induced pulmonary inflammatory response is enhanced during the acute phase of influenza infection date: 2018-07-05 journal: Intensive Care Med Exp DOI: 10.1186/s40635-018-0182-5 sha: doc_id: 3099 cord_uid: a0acr28o BACKGROUND: Influenza infections are often complicated by secondary infections, which are associated with high morbidity and mortality, suggesting that influenza profoundly influences the immune response towards a subsequent pathogenic challenge. Herein, we investigated whether influenza infection results in an enhanced or suppressed innate immune response upon a secondary challenge with bacterial lipopolysaccharide (LPS) in either the acute or the recovery phase of infection. keywords: acute; alpha; analysis; animals; bacterial; challenge; concentrations; content; cytokine; data; days; effect; enhanced; fig; homogenates; il-10; il-6; immune; infected; infection; inflammatory; influenza; influenza infection; innate; levels; lps; lung; manuscript; mice; mock; mpo; nacl; neutrophil; patients; phase; plasma; pneumonia; post; pro; pulmonary; recovery; response; results; secondary; studies; study; tissue; tnf; use; virus cache: cord-003099-a0acr28o.txt plain text: cord-003099-a0acr28o.txt item: #15 of 105 id: cord-004067-psjyjvbu author: Zhou, Yile title: The regulatory effect of microRNA-21a-3p on the promotion of telocyte angiogenesis mediated by PI3K (p110α)/AKT/mTOR in LPS induced mice ARDS date: 2019-12-26 words: 5193 flesch: 44 summary: TCs culture medium enhanced hemangioendothelioma endothelial cells (EOMA cells) proliferation, which was blocked by the miR-21a-3p inhibitor. TCs proliferation was demonstrated to be regulated by transforming growth factor-β (TGF-β) and mediated by the PI3K p110α subunit and the PI3K/AKT/mTOR signalling pathway keywords: acute; akt; analysis; angiogenesis; angiogenic; antisense; ards; assay; blood; boston; cd31; cells; china; control; cst; culture; database; degs; differential; distress; downstream; e2f8; effect; efnb2; endothelial; enos; eoma; epas1; expression; factor; fig; function; growth; inflammatory; inhibitor; injury; interstitial; levels; lps; lung; mechanisms; medium; mesenchymal; mice; mir-21a-3p; mir-221; mirnas; mmol; model; mouse; mrna; mtor; non; notch; online; p110α; pathway; pi3k; present; primer; processes; proliferation; protective; protein; protocol; regulation; renal; repair; respiratory; sense; signalling; stem; stimulation; string; study; subunit; syndrome; target; tcs; telocytes; therapeutic; tissue; transcription; treatment; underlying; upregulated; vascular; vegf; vessel cache: cord-004067-psjyjvbu.txt plain text: cord-004067-psjyjvbu.txt item: #16 of 105 id: cord-004140-ujzrqzv3 author: Lu, Xiaying title: Rolipram Protects Mice from Gram-negative Bacterium Escherichia coli-induced Inflammation and Septic Shock date: 2020-01-13 words: 3480 flesch: 45 summary: The overwhelming release of pro-inflammatory cytokines plays an important role in the pathology of sepsis. In contrast, administration of rolipram effectively reduced the production of pro-inflammatory cytokines and chemokines, and further increased the levels of IL-10. keywords: analysis; anti; balf; cells; china; coli; cytokines; degrees; drug; effect; erk; fig; group; induced; inflammation; inflammatory; inhibition; injection; injury; jnk; kidney; lipopolysaccharide; liver; lps; lung; mapk; mice; mouse; multiple; neutrophil; nuclear; organ; p38; p65; pathway; pbs; phosphorylation; production; protective; protein; rate; renal; response; results; role; rolipram; sepsis; septic; serum; severe; shock; signaling; survival; time; tissue; treatment cache: cord-004140-ujzrqzv3.txt plain text: cord-004140-ujzrqzv3.txt item: #17 of 105 id: cord-004282-tox3tuzz author: Capellini, Francesca Maria title: Characterization of MDCK cells and evaluation of their ability to respond to infectious and non-infectious stressors date: 2019-12-04 words: 4334 flesch: 47 summary: In this study, we also demonstrated the effect of cell passages on MDCK gene expression; this is a very important issue that must be considered not only during gene expression studies but above all in host/pathogen interaction studies because both passage level and aging can alter TLRs and cytokine gene expression. Cell culture MDCK cells (Madin-Darby Canine Kidney, IZSLER biobank OIE code BS CL 64) were grown in Minimum Essential Medium (MEM, Carlo Erba Reagents S.r.l., Milano, cat FA30WL0440500) enriched with 10% (v/ v) fetal calf serum (FCS, GIBCO TM , Thermofisher scientific, Milano, cat 10437-036) and a mixture of antibiotics (penicillin and streptomycin, 1% v/v, Carlo Erba Reagents S.r.l., Milano, cat FA30WL0022100). keywords: ability; activation; aging; basal; cadmium; canine; cat; cd2; cells; concentration; control; cytokine; data; dct; different; dogs; effects; epithelial; et al; exposure; expression; fig; gene; gene expression; host; human; il-1b; il-6; immune; infectious; inflammatory; innate; inos; kidney; levels; line; lps; mdck; milano; model; modulation; myd88; negative; non; p65; passage; production; razzuoli; release; response; results; significant; stressors; studies; study; time; tlr4; tlr5; tlr9; toxicity; transcription; treatment cache: cord-004282-tox3tuzz.txt plain text: cord-004282-tox3tuzz.txt item: #18 of 105 id: cord-004754-5596p4ma author: Duan, X. title: Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV) date: 2014-04-06 words: 4888 flesch: 45 summary: For determining the titre of extracellular virus, medium from PRRSV infected cells was collected and centrifuged at 9000 Â g for 15 min. 100 ml of tenfold dilutions of the supernatants were inoculated in 96-well microtiter plates (Nalge Nunc, Roskilde, Denmark) previously seeded with AMf. Table 1 shows the virus titres and percentage of PRRSV positive cells in freshly isolated and one day cultivated AMf at 1, 24 and 48 h after PRRSV inoculation. keywords: 41d5; activation; alveolar; amf; amφ; antibodies; antigen; binding; blood; bmo; cells; concentration; cultivation; day; determined; different; differentiation; effect; infection; inoculation; isolated; lineage; lps; mabs; macrophages; medium; membrane; monoclonal; monocytes; negative; pbs; percentage; pigs; plates; pma; pmf; porcine; positive; pre; protein; prrsv; replication; reproductive; respiratory; speci; staining; susceptibility; swine; syndrome; times; titre; treatment; viral; virus; vitro cache: cord-004754-5596p4ma.txt plain text: cord-004754-5596p4ma.txt item: #19 of 105 id: cord-005497-w81ysjf9 author: None title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103795 flesch: 50 summary: Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients. keywords: 1st; 24h; 95%ci; abdominal; ability; abnormal; absence; absolute; abstract; accuracy; acid; acquired; activated; activation; activity; acute; acute care; addition; adjusted; adjustment; administration; admission; admission patients; adult patients; adults; adverse; afxa; age; aged; agents; agreement; aim; aims; airway; aki; aki patients; albumin; analgesia; analysis; anesthesia; angiography; animals; antibiotic; anticoagulation; antimicrobial; antixa; anxiety; aof; apache; application; approach; appropriate; april; ards; area; arf; arrest; arrest patients; arterial; artery; assay; assessment; associated; association; athens; atx; auc; audit; available; average; bacteremia; bacterial; balance; barriers; baseline; bbv; bedside; benefit; better; bilirubin; biomarkers; bleeding; blood; blood pressure; bmi; body; bolus; brain; breathing; bundle; burden; burn; burnout; bypass; cabg; cancer; cardiac; cardiac arrest; cardiac patients; cardiac surgery; cardiopulmonary; cardiothoracic; cardiovascular; care; care hospital; care patients; care unit; cartridge; cases; catheter; cause; cbt; cci; cdi; cells; center; central; centre; cerebral; cfs; challenge; changes; characteristics; characterized; chart; chest; children; chloride; chronic; circuit; circulation; circulatory; citrate; classification; clearance; clinical; clinicians; clot; clotting; cmh; coagulation; coagulopathy; cohort; cohort study; collection; combination; combined; committee; common; community; comorbidities; comparable; compare; comparison; complex; compliance; complications; components; compression; concentration; conclusions; conditions; confidence; consciousness; consecutive patients; consent; consumption; continuous; control; control group; controlled; conventional; coronary; correct; correlation; costs; count; course; cpb; cpr; creatinine; criteria; critical; critical care; cross; crp; crrt; csf; cuff; cultures; cumulative; current; curve; cvc; daily; damage; data; database; dataset; day mortality; days; death; december; decision; decrease; degree; delirium; delivery; demographic; department; design; detecting; detection; determination; development; device; diabetes; diagnosis; diaphragm; diarrhea; difference; difficult; dimer; direct; discharge; disease; distress; distribution; doctors; donors; dose; drug; duration; dysfunction; dysglycemia; earlier; early; ecco; ecg; ecls; ecmo; ecmo patients; ecpr; effect; effective; efficacy; elderly patients; elective; electronic; elevated; elevation; emergency; emergency patients; end; endothelial; endotoxin; endpoint; enteral; episodes; ethics; evaluation; events; evidence; excess; exclusion; existing; expected; experience; exposure; expression; extracorporeal; factors; failure; family; favorable; feasible; features; feedback; female; fever; fibrinogen; figure; filter; final; findings; fio; flow; fluid; follow; fraction; fracture; frail patients; frailty; free; freiburg; frequency; frequent; function; future; gas; gender; general; generation; genes; germany; gfap; glasgow; global; glucose; goal; good; grade; gram; greater; group; group patients; guidelines; half; handover; head; health; healthcare; heart; help; hemodynamic; hemoperfusion; hemorrhage; heparin; higher; higher mortality; highest; history; hospital; hospital admission; hospital cardiac; hospital discharge; hospital mortality; hospital stay; hospitalization; hours; hrs; human; hypertension; hyponatremia; icp; icu admission; icu care; icu discharge; icu length; icu mortality; icu patients; icu population; icu staff; icu stay; icuca; icus; ihca; iii; il-6; ill; illness; immune; immunosuppression; impact; impairment; implementation; important; improved; improvement; imv; incidence; incidents; inclusion; income; increased; independent; index; individual; induction; infection; inflammation; inflammatory; influence; information; informed; infusion; inhalation; initial; initiation; injuries; injury; inpatient; insulin; intake; intensive care; interaction; interval; intervention; intra; intravenous; introduction; intubated; intubation; invasive; involved; involvement; iqr; ir+f; iron; ischemia; italy; january; japan; july; kdigo; ketoacidosis; kidney; knowledge; laboratory; lack; lactate; large; lead; leading; learning; left; length; levels; levosimendan; life; likely; limited; linear; literature; liver; local; logistic; long; longer; los; loss; lower; lps; lung; main; major; majority; making; male; malignancy; management; map; march; markers; mass; max; maximum; mcs; mdr; mean; mean age; measured; measurements; mechanical; median; median icu; medical; medical care; medical patients; medication; medicine; members; membrane; mental; methods; mhla; mice; microstructure; min; minimal; minutes; mixed; mmhg; mmol; model; moderate; modified; mods; monitored; monitoring; monocytes; months; morbidity; mortality; mortality rate; multicenter; multidisciplinary; multiple; multivariate; muscle; music; myocardial; national; necessary; need; negative; neurological; neutrophils; new; news; noise; non; normal; novel; november; number; nurses; nursing; nutritional; obese patients; objective; observational study; occurrence; october; odds; ohca; old; ongoing; onset; ooh; operating; optimal; oral; order; organ; outcome; output; overall; oxygen; oxygenation; p<0.001; p<0.05; pad; pain; pamv; panel; pao; parameters; participants; pathogens; patients; pattern; pci; pct; peak; pediatric; peep; percentage; performance; perfusion; period; perioperative; peripheral; peritonitis; physical; physicians; physiological; pics; placebo; plasma; platelet; pneumonia; poca; point; polymorphism; poor; population; position; positive; possible; post; postoperative; potential; practice; predict; predictive; predictors; prescribed; presence; present; present study; presentation; pressure; prevalence; prevention; previous; primary; prior; problem; procalcitonin; procedure; process; product; prognostic; project; prolonged; promising; properties; proportion; prospective; protein; protocol; psychiatric; psychological; pts; public; pulmonary; pulse; pupillometry; purpose; quality; quantitative; questionnaire; randomized; range; rapid; rate; rats; rbc; rca; reactive; reasons; receiver; recent; record; recovery; reduced; reduction; regional; registered; regression; related; relationship; relative; relevant; reliability; removal; renal; renin; replacement; reported; reports; research; resistance; respect; respiratory; responders; response; results; resuscitation; retinal; retrospective; retrospective study; return; review; rhythm; right; risk; risk factors; risk patients; roc; role; room; rosc; routine; s1p; safety; samples; satisfaction; sbf; sbt; scale; school; score; secondary; sedation; selected; sensitive; sensitivity; sepsis; sepsis patients; sepsis-3; septic; septic shock; septicyte; sequential; series; serum; setting; severe; severe patients; severe sepsis; severity; sex; shock; shock patients; shockable; shorter; significant; signs; similar; simulation; single; size; skin; sleep; small; sofa; solution; specific; specificity; spontaneous; staff; stage; standard; standardized; start; statistical; status; stay; stmv; strategies; strategy; strength; stress; stroke; strong; students; studies; study; study group; study period; subgroup; subjects; subsequent; subset; support; surgery; surgical; surgical patients; survey; survival; survivors; symptoms; syndrome; system; systemic; table; target; tavi; tbi; tbi patients; teaching; team; technique; teg; temperature; term; tertiary; test; testing; tgp; therapeutic; therapies; therapy; thickness; threat; threshold; thrombin; thrombosis; tidal; time; tissue; tone; tool; total; tracheal; tracheostomy; traditional; training; transfusion; transplantation; trauma patients; traumatic; treatment; trend; triage; trial; troponin; tube; type; uch; ultrasound; unit; united; university; university hospital; unknown; urinary; urine; use; useful; uws; validation; value; vancomycin; vap; variability; variables; vasopressor; vein; venous; ventilation; ventricular; vital; volume; vri; ward; wbc; weaning; week; weight; women; work; working; workload; worse; years; δci cache: cord-005497-w81ysjf9.txt plain text: cord-005497-w81ysjf9.txt item: #20 of 105 id: cord-005607-b1a39hhw author: Bellingan, G title: Leukocytes: friend or foe date: 2000 words: 3830 flesch: 35 summary: As most infections occur primarily in the tissue and not in the blood stream, extravasation of leukocytes is essential in bring inflammatory cells and foreign pathogens into contact. In an intricate pathway LPS has been shown to complex with circulating lipopolysaccharide binding protein (LBP) which binds to the CD14 receptor leading to inflammatory cell activation [52] . keywords: activation; adaptive; adhesion; agents; antimicrobial; bacteria; body; capacity; care; cd14; cells; clear; cytokines; damage; drosophila; endothelial; endotoxin; epithelial; essential; excessive; free; function; hdl; host; immune; infection; inflammation; inflammatory; inflammatory response; innate; intensive; invading; key; leukocytes; lipopolysaccharide; lipoprotein; lps; mediator; multiple; neutrophils; pathogens; peptides; pro; production; proteins; release; response; role; state; synthesis; system; systemic; tissue; tnf; toll cache: cord-005607-b1a39hhw.txt plain text: cord-005607-b1a39hhw.txt item: #21 of 105 id: cord-005727-li8pwigg author: None title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 words: 102900 flesch: 50 summary: Postoperative sedation with both midazolam and dexmedetomidine were effective in suppressing oxidative stress in ICU patients. Poorly controlled pain in the postoperative period can lead to slow recovery and life threatening complications, especially in elderly patients. The use of a tidal volume of 6 ml/kg of predicted body weight is part of the management of patients presenting with ARDS (1) and prevents ventilator induced lung injury in ICU patients undergoing mechanical ventilation (2) . keywords: 1st; abdominal; abnormal; absence; access; accurate; acetaminophen; acidosis; acknowledgment; activation; activities; activity; actual; acute; addition; adhesion; administration; admission; admittance; adult patients; adverse; age; agreement; aim; airway; aki; albumin; algorithm; alternative; anaemia; analgesia; analysis; anesthesia; angiography; animals; anova; antibiotic; anticoagulation; antimicrobial; anxiety; aortic; apache; apc; apoptosis; application; approach; appropriate; approval; april; ards; area; arrest; arterial; artery; aspects; assay; assessment; associated; association; asv; attention; auc; audit; available; average; awareness; bacterial; balance; baseline; bed; bedside; beneficial; benefit; best; better; bias; biomarkers; bland; bleeding; blood; blood glucose; bmi; body; bolus; brain; bsi; bundle; burn; cabg; calibration; capillary; cardiac; cardiopulmonary; cardiovascular; care; care patients; care unit; cases; categories; catheter; cause; ccu; cells; center; central; centre; cerebral; challenge; changes; characteristics; charts; chest; chi; chronic; clearance; clinical; clinicians; clp; cmh; coefficient; cohort; coli; coma; combination; comfort; common; communication; comparison; complete; compliance; complications; concentration; concept; conclusions; conditions; consecutive patients; consultants; context; continuous; contrast; control; control group; conventional; cooling; copd; coronary; correct; correlated; correlation; cost; course; cpis; cpr; crbsi; criteria; critical; critical care; critical patients; cross; crp; crrt; crt; cuff; culture; current; curve; cvc; cytokines; daily; data; database; days; death; december; decision; decrease; degree; delay; delirium; delivery; demographic; density; department; descriptive; detection; determined; developed; development; deviation; device; diabetes; diabetic patients; diagnosis; diastolic; differences; different; difficult; direct; discharge; discomfort; disease; distress; distribution; doctors; dose; drug; duration; dysfunction; earlier; early; ecg; echocardiography; education; effective; effectiveness; effects; efficacy; elderly patients; elective; elevated; emergency; end; endothelial; endotoxemia; endotracheal; environment; epidural; episodes; equipment; errors; esicm; established; estimated; evaluation; events; evidence; exchange; exclusion; experience; experimental; expression; factors; failure; families; family; females; femoral; fever; fibrillation; fig; figure; final; findings; finger; fio; flow; fluid; focus; following; forearm; france; frequency; frequent; functional; gas; gcs; gender; general; general icu; germany; glasgow; global; glucose; glyceamic; goals; good; graft; greater; group; group p; guidelines; half; hand; healthy; heart; help; hemodynamic; hemorrhage; heparin; hepatic; hfo; high; higher; higher mortality; highest; hospital; hospital cardiac; hospital mortality; hospitalization; hours; human; hypernatremia; hypertension; hypoglycaemia; hypothermia; hypovolemia; icp; icu admission; icu discharge; icu length; icu mortality; icu patients; icu stay; icus; il-6; ill; illness; imaging; immune; impact; implementation; important; improved; improvement; improving; incidence; incidents; inclusion; increased; increasing; independent; index; indicator; individual; induced; infants; infection; inflammation; inflammatory; influence; influenza; information; informed; infusion; initial; injury; insertion; instability; insulin; intact; intensive; intensive care; international; intervention; interviews; intestinal; intracranial; intravenous; introduction; intubation; invasive; investigation; involved; ischemia; issues; itu; january; key; kidney; knowledge; known; laboratory; lack; lactate; large; lbnp; lead; leading; learning; left; length; leukocyte; levels; life; likely; limit; limited; linear; literature; little; liver; local; logistic; long; longer; loss; lower; lps; lung; lymphocyte; main; major; majority; making; male; malignancy; management; mann; mannitol; manual; map; marker; matched; maximum; mean; mean age; measured; measurement; mechanical; median; medical; medical patients; medicine; members; membrane; metabolic; methods; mice; microcirculation; microdialysis; microvascular; mild; min; mixed; mmhg; mmol; model; moderate; modified; monitored; monitoring; months; morbidity; mortality; mortality rate; mri; multidisciplinary; multiple; multivariate; muscle; myocardial; n =; national; nava; necessary; need; negative; neurological; neurosurgical; neutrophils; new; niacin; nice; nirs; niv; non; noninvasive; norepinephrine; normal; nosocomial; number; nurses; nursing; objectives; observational; observational study; occlusion; occurrence; october; odds; ohca; ohca patients; old; olt; onsd; onset; operation; optimal; order; organ; outcome; output; overall; oxygen; oxygenation; p =; pain; pao; parameters; participants; particular; patients; pattern; pci; pct; peak; percentage; performance; perfused; perfusion; period; peripheral; phagocytosis; phase; physicians; physiological; picco; pigs; placebo; plasma; platelets; pneumonia; point; poor; population; positioning; positive; possible; post; postoperative; potential; ppv; practice; predictive; predictor; preliminary; prescribing; presence; present; pressure; prevalence; prevention; previous; primary; prior; probe; problems; procalcitonin; procedure; process; products; professionalism; prognosis; program; project; prolonged; prophylaxis; propofol; proportion; prospective; protein; protocol; psv; pts; pulmonary; purpose; quality; quantitative; questionnaire; r =; radial; randomized; range; rapid; rate; ratio; rats; reactive; reason; recent; receptor; recommendations; recorded; recovery; reduced; reduction; reference(s; region; regional; regression; related; relationship; relatives; relevant; reliable; removal; renal; repair; replacement; reported; required; research; resistance; respect; respiratory; respondents; response; results; resuscitation; retrospective; retrospective study; review; rewarming; rhapc; rhythm; rifle; right; risk; risk patients; role; room; routine; safety; sah; saline; samples; sampling; saps; satisfaction; saturation; scale; score; sdf; second; secondary; sedation; sensitivity; sensor; sepsis; septic; septic patients; serum; service; sessions; set; setting; severe; severe sepsis; severity; sham; shock; short; signal; significant; similar; simulated; single; site; skills; skin; small; sodium; sofa; software; solution; sound; specific; specificity; spv; square; staff; standard; starting; state; statistical; status; stay; step; strategies; strategy; stress; stroke; student; studies; study; study group; study period; subjects; sublingual; subsequent; successful; sugar; suggested; support; surface; surgery; surgery patients; surgical; surgical patients; survey; survival; survivors; svo; svv; symptoms; syndrome; system; systemic; systolic; table; target; tbi; tbi patients; teaching; team; teamwork; technique; temperature; term; tertiary; test; tgc; therapeutic; therapies; therapy; thoracic; thought; thrombocytopenia; tidal; time; tissue; tlr2; tnf; tool; total; tptd; tracheostomy; trainees; training; transfer; transfusion; transplantation; trauma; trauma patients; traumatic; treatment; trial; troponin; trs; tube; type; ulcer; underwent; unit; university; unknown; upper; urinary; urine; usa; use; useful; value; vap; variability; variables; variation; vasopressor; venous; ventilated; ventilation; ventilatory; ventricular; vessel; vili; volume; vot; ward; water; weaning; week; weight; whitney; women; work; working; worse; years cache: cord-005727-li8pwigg.txt plain text: cord-005727-li8pwigg.txt item: #22 of 105 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: + +; -the; 0.001; 1st; 2nd; 3rd; 48h; 546c88; 900c; aaar group; aaar patients; abdominal; abnormalities; absence; absent; absolute; absorption; access; accident; account; accumulation; accuracy; accurate; acid; acidosis; activation; active; activities; activity; actual; acute; acute lung; acute myocardial; acute renal; acute respiratory; adaptation; addition; adequacy; adequate; adhesion; administration; admission; admission patients; adopted; adult patients; adults; advanced; advantages; adverse; aeruginosa; affected; age; aged; aged patients; agents; aggregation; agreement; aid; aim; airway; airway pressure; alarm; albumin; alive; alpha; alterations; altered; alternative; alveolar; ambulance; ami patients; amounts; anaerobes; anaerobic; anaesthesia; analgesia; analysis; anemia; anesthetic; anesthetized; angiography; angiotensin; animals; anova; anp; antagonist; anterior; antibiotics; antibody; anticoagulation; antioxidant; antipyretics; aorta; aortic; apache; apache ii; apnoeic patients; apparatus; appearance; application; applied; approach; appropriate; approval; april; aptt; ards group; ards patients; area; arf; arginine; arrest; arrhythmias; arrival; arterial; arterial blood; arterial pressure; arteries; arterio; artery; artificial; aspects; aspiration; assay; assess; assessment; assist; assisted; associated; association; asthma; atc; atelectasis; athens; attacks; attempts; august; aureus; authors; autologous; automatic; autopsy; available; average; b.a; babies; background; bacteremia; bacterial; balance; balf; balloon; barbiturates; basal; baseline; basis; baxter; bed; beds; bedside; beginning; belgium; beneficial; benefit; bennett; best; beta; better; bicarbonate; bilateral; bilirubin; biochemical; biological; birth; bleeding; blind; blockade; blocker; blood; blood cultures; blood cyanide; blood flow; blood gas; blood lactate; blood loss; blood oxygen; blood pressure; blood samples; blood transfusion; blood volume; blunt; body; bolus; bone; bovine; bpap; bpm; brain blood; breathing; breaths; bronchial; bronchogram; bronchoscopy; bulb; burn; bypass; cabg; calculated; calibration; calories; cancer; candida; cannula; capacity; capillary; carbohydrate; carbon; cardiac; cardiac arrest; cardiac failure; cardiac function; cardiac index; cardiac output; cardiac patients; cardiac surgery; cardiogenic; cardiomyoplasty; cardiopulmonary; cardiovascular; care patients; care unit; carotid; cases; category; catheter; catheterization; cause; cells; cellular; center; central; cephalosporins; cerebral; cerebral blood; certain; cgmp; changes; changes patients; characteristics; chest; chfjv; children; choice; chronic; cip; circuit; circulation; circulatory; cis; cisapride; clamp; clamping; classification; clearance; clinical; clonidine; closed; cmh20; cmv; co2; coagulation; coefficient; cohort; cold; collection; colonization; coma; comatose patients; combination; combined; committee; common; comparable; comparative; comparison; compartment; compensation; complement; complete; complex; compliance; complicated; complications; components; computer; concentration; conclusion patients; conclusions; concomitant; conditions; congenital; congestive; connected; consecutive patients; consequence; considerable; constant; consumption; contamination; content; continued; continuous; contrary; contrast; control group; control patients; controls; contusion; conventional; copd patients; coronary; correct; correlate; correlation; corresponding; cortisol; cost; count; course; cpap; cpb; cpk; cpl; cpr; creatinine; criteria; criterion; critical care; critical patients; cross; csf; cultures; current; curve; cvp; cvvh; cxr; cyanide; cytokines; daily; damage; data; data analysis; date; days; dcm; dead; death; death patients; deceased patients; december; decision; decrease; decreasing; deep; defect; degradation; degree; delay; delayed; delivery; demand; demographic; department; dependent; dependent patients; dept; design; detection; deterioration; determination; determined; development; deviation; device; diabetes; diagnosis; dialysis; diameter; diastolic; diet; differences; different; differential; difficult; dioxide; diphtheria; direct; discharge; discontinuation; discrepancies; discrimination; discussion; disease; disorders; distress; distribution; disturbances; diuresis; do2; do2crit; dobutamine; doctors; dogs; donation; donor; dopexamine; doppler; dosage; dose; double; drainage; drop; drugs; dry; dudng; duodenal; duration; dynamics; dysfunction; dyspnea; earlier; early; easy; ecg; echocardiography; ecmo; edema; eeg; effect; effective; effectiveness; efficacy; efficiency; efforts; effusion; ejection; elderly patients; electrical; electrolyte; elevated; elevation; elisa; embolism; emergency; emergency patients; enalaprilat; end; endocarditis; endoscopy; endothelial; endotoxin; endotracheal; energy; enoxaparin; enteral; entire; entry; environment; enzyme; epidural; epinephrine; episodes; equal; equation; equipment; erythropoietin; esophageal; essential; established; estimate; estimation; etc; etco2; ethical; ethics; etiology; evaluation; events; evidence; evlw; examination; excellent; excessive; exchange; exclusion; excretion; existing; exogenous; experience; experimental; expired; exposure; expression; extensive; extent; external; extracorporeal; extraction; extreme; facilities; factors; failure; failure patients; fall; fast; fatal; fatigue; favourable; february; feedback; feeding; female; femoral; fentanyl; fever; fiberoptic; fibrillation; fibrin; fibrinogen; fick; figure; filling; filter; filtration; final; findings; fio2; fire; flail; flow; fluconazole; fluid; flux; focus; fold; following; foreign; forms; formula; foy; fraction; france; free; frequency; frequent; frg; function; future; ganz; gas; gastric; gastrointestinal; gcs; general; generation; germany; gestational; glasgow; global; glucagon; glucose; glycogen; goal; good; grade; gradient; graft; grafting; gram; granulocytopenic patients; greater; greece; group; group b; group blood; group ii; group l; group patients; guidelines; h20; half; hand; hbr; head; headtrauma patients; healthy; heart; heart failure; heart rate; heart surgery; help; hemodialysis; hemodynamic; hemoglobin; hemorrhage; heparin; hepatic; hepatocytes; heroin; high; high levels; high mortality; high risk; higher; highest; history; hiv; hme; hmef; home; hormonal; hormone; hospital; hospital mortality; hospitalisation; hourly; hours; hrs; hrv; human; humoral; hydrochloride; hypertension; hyperventilation; hypothesis; hypovolemic; hypoxemia; hypoxemic patients; hypoxia; i.c.u; i.v; icg; ich; icp; icpe; icu admission; icu day; icu mortality; icu patients; icu pts; icu stay; icu treatment; icus; identical; iger; ii score; iii; il-6; il-8; ill; illness; ilv; immediate; immune; immunity; impact; impaired; impairment; impedance; important; improved; improvement; incidence; inclusion; increased; index; indications; indicator; indices; indirect; individual patients; indomethacine; induced; induction; infants; infection; inferior; inflammation; inflammatory; inflated; influence; information; informed; infusion; inhalation; inhaled; inhibitor; initial; injured; injuries; injury; inos; inotropes; inotropic; insertion; inspiratory pressure; inspired; institute; institutional; insufficiency; insulin; insult; intensity; intensive; intensive care; interaction; interest; intermittent; internal; interstitial; intervals; interventions; intoxication; intracerebral; intracranial; intramucosal; intraoperative; intrapulmonary; intravascular; intravenous; intrinsic; introduction; intubated patients; intubation; invasive; investigate; investigation; involved; involvement; ippv; ips; ischemia; isoflurane; isolated; isolation; italy; itbv; items; ivh; ivig; january; jejunal; jet; jugular; july; june; kidney; kind; known; kpa; laboratory; lack; lactate; lactate levels; lactatemia; large; later; lavage; lead; left; length; lesions; lethality; leukocyte; levels; life; like; likely; limb; limited; limits; linear; lipid; liquor; literature; little; liver; loading; local; logistic; long; longer; loss; losses; lower; lowering; lowest; lps; lung; lung injury; lung volume; lvad; main; main results; maintain; maintenance; major; majority; making; male; malignant; management; mandatory; manner; mannitol; map; march; marked; markers; mask; massive; material; maximal; maximum; mbar; mean; mean age; mean apache; mean arterial; mean blood; mean duration; mean icu; mean pulmonary; mean time; mean values; measured; measurements; measuring; mechanical; mechanical ventilation; mechanism; median; medical; medication; medicine; membrane; mentioned; mesenteric; metabolic; methods; microbiological; micu; midazolam; middle; mild; min; minor; minutes; mixed; mixture; mmhg; mmol; model; moderate; modified; mof; moisture; molecules; monitoring; months; morbidity; morphine; mortality; mortality rate; mosf; mpap; mpm; mri; mrsa; msec; mucosal; multidisciplinary; multiple; multivariate; murray; muscle; myocardial; n =; n=10; n=5; n=6; n=7; n=9; nasogastric; national; natural; necessary; necrosis; need; negative; negative pressure; neonatal; neonates; neopterin; nerve; nervous; network; neurological; neurological patients; neuromuscular; neutropenic patients; new; newborns; nitric; nitrogen; nmol; no2; no3; non; noninvasive; nonsurvivors; noradrenaline; normal; nosocomial; nox; npe; number; nurses; nursing; nutrition; o.05; obese patients; objectives; observation; observed; observed patients; obstetric patients; obstruction; occlusion; occurrence; old; ones; onset; operating; operation; optimal; order; organ; organ failure; organism; origin; outcome; output; overall; overdose; overload; oxidase; oxidation; oxide; oxygen; oxygenation; oxygenators; p =; p0.1; p<0.001; p<0.05; pace2; paco; paediatric patients; paf; pain; pancreatic; pancreatitis; pao2; paper; parallel; paralysed patients; paralyzed; parameters; parenteral; partial; particular; past; pathogenesis; pathogens; pathological; pathology; patient days; patients; patients ability; patients characteristics; patients conventional; patients hemodynamic; patients methods; patients non; patients outcome; patients peep; patients therapy; patients treatment; pattern; pav; paw; pci; pco; pco2; pcwp; pdr; peak; pediatric; pediatric patients; peep; pel; people; percentage; performance; perfusion; pericardial; period; period patients; peripheral; peritoneal; peritonitis; permeability; peroxidation; persistent; personal; pgi2; phase; phd; phi; physician; physiological; physiology; piece; pigs; pip; placebo; plasma; plasma levels; plasmapheresis; plateau; platelet; play; pleural; pmn; pnct; pneumonia; pneumothorax; po group; po2; points; poisoning; poor; population; porcine; portal; position; positioning; positive; positive blood; positive patients; possibility; possible; postoperative; postoperative patients; postoperative period; potassium; potential; ppa; pph; ppm; practice; precise; predictive; pregnancy; pregnant; preliminary; preload; premature; preoperative; preparation; prescribed; presence; present; present study; presentation; pressure; pressure score; pressure support; pressure time; pressure ventilation; prevalence; prevention; prevents; previous; prevotella; primary; prior; prism; probability; problem; procedure; process; processing; proct; products; professional; profiles; prognosis; program; programme; progressive; prolongation; prolonged; promising; prone; pronounced; properties; prophylaxis; propofol; proportional; prospective; prospective study; prostacyclin; protection; protein; protocol; providing; psb; pseudomonas; psv; ptca; ptr; pts; pulmonary; pulmonary artery; pulmonary blood; pulmonary embolism; pulmonary function; pulmonary gas; pulmonary hypertension; pulmonary pressure; pulmonary vascular; pulse; pump; puritan; purpose; purulent; pvr; pvs patients; pwp; pwt; qrs; qtc; quality; quantitative; question; quick; quinine; r =; radicals; rain; randomized; range; rank; rapid; rare; rate; rats; ray; reach; reaction; ready; reason; recent; recipients; recombinant; records; recovery; recruitment; rectal; reduced; reducing; reduction; reference; reflex; refractory; regard; regimen; regional; registered; regression; regular; regulated; rehabilitation; related; relationship; relative; release; relevant; reliable; removal; renal; renal failure; renin; replacement; reported; requirements; research; residual; resistance; respect; respiratory; respiratory failure; respiratory system; responders; response; responsible; resulted; results; resuscitation; retrospective; return; reversible; review; revision; right; rise; risk; risk patients; role; room; route; routine; rtotlsf; rvef; safe; safety; saline; samples; sao2; saps; saturation; saving; scale; scan; score; scoring; sdd; second; second group; secondary; secretions; sedation; segment; selam-1; selectin; selective; self; sem; sensitive; sensitivity; sepsis; septic patients; septic shock; sequelae; serial; series; serum; service; servo; setting; severe; severe acute; severe ards; severe patients; severe sepsis; severity; sex; shock; shock group; shock patients; short; shorter; shows; shunt; shvo; sicam-1; siemens; significant; significant changes; significant correlation; significant differences; significant increase; signs; similar; simple; simplified; simultaneous; single; sinus; sirs; site; situations; size; sjo; skin; sleep; slight; slope; small; smaller; smokers; sodium; software; soluble; solution; sores; source; space; special; species; specific; specificity; specimens; spectrum; splanchnic; spontaneous; spp; square; stability; stabilization; stable; stable patients; staff; stages; standard; standardized; staphylococcus; start; starting; state; static; statistical; status; stay; stenosis; step; sterile; steroid; stimulation; stimulus; strains; strategies; strategy; stress; stroke; structure; student; studies; study; study group; study period; study results; subarachnoid; subgroups; subjects; subsequent; substances; substantial; successful; sufentanil; suffering; sufficient; supine; supply; support; support ventilation; surface; surfactant; surgery patients; surgical icu; surgical patients; survey; survival; survived; survived patients; surviving; survivors; susceptible; sustained; svo2; svr; swan; symptoms; syndrome; syndrome patients; synthase; system; systemic; systolic; systolic blood; t =; tachycardia; task; tbars; tcd; team; technique; temperature; tendency; terms; tertiary; test; tested; tga; therapeutic; therapy; thermal; thermodilution; thoracic; threatening; thrombolytic; thrombosis; tidal; tidal volume; tile; time; tissue; tnf; tnt; tone; tonometer; tool; total; total respiratory; toxic; toxicity; tpn; tracheal; tracheal pressure; tracheostomy; training; tranmatised patients; transducer; transfer; transfusion; transient; transit; transplantation; transplanted; transport; trauma patients; traumatic; treated; treatment; treatment group; trend; trial; triggering; true; tube; tubing; tumor; type; typical; ulcer; ultrasound; unable; unchanged; underlying; underwent; unit; unit patients; university; unknown; untreated; upper; uptake; urea; urgent; urinary; urine; usa; use; useful; usefulness; usual; values; valve; valvular; vap; variability; variables; variance; variation; varied; vascular; vasoactive; vasoconstriction; vasodilator; vasoreactivity; vco2; vein; velocity; venous; venous blood; venous pressure; ventilated; ventilation; ventilation patients; ventilatory; ventricle; ventricular; verapamil; vessels; victims; vital; vo2; volume; volunteers; vsmc; wall; ward; warm; wave; wbc; wean patients; weaning; wedge; wedge pressure; weeks; weight; white; wide; wilcoxon; withdrawn; wobadd; women; work; worse; wound; xanthine; years; years patients; younger patients; yrs; zeep cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #23 of 105 id: cord-005832-p1joajvn author: Liu, Zhicheng title: Protective effect of gossypol on lipopolysaccharide-induced acute lung injury in mice date: 2013-02-23 words: 3098 flesch: 47 summary: Blank control and LPS group mice were given an equal volume of distilled water by i.p. 1 h later, mice were slightly anesthetized with an inhalation of diethyl ether, 10 lg of LPS in 50 ll PBS was instilled intranasal (i.n.) to induce lung injury. The purpose of this study was to evaluate the effect of gossypol on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice. keywords: activation; activity; acute; ali; anti; balf; blood; cells; control; dex; effect; fig; gossypol; group; ijb; il-1b; il-6; induced; infiltration; inflammatory; injury; lps; lung; mapks; mice; mouse; mpo; neutrophils; p38; p65; phosphorylation; production; protein; pulmonary; ratio; results; specific; study; tnf; treatment cache: cord-005832-p1joajvn.txt plain text: cord-005832-p1joajvn.txt item: #24 of 105 id: cord-005872-w1x1i0im author: Volk, T. title: Endothelium function in sepsis date: 2000 words: 8880 flesch: 21 summary: Endothelial cells lack CD14 receptors and LPS effects on endothelial cells generally require the presence of CD14 in the serum. Molecular analysis of a novel bidirectional pathway Two distinct phospholipases C of Listeria monocytogenes induce ceramide generation, nuclear factor-kappa acivation, and E-selectin expression in human endothelial cells Internalin B is essential for adhesion and mediates the invasion of Listeria monocytogenes into human endothelial cells Activation of human endothelial cells by viable or heat-killed gram-negative bacteria requires soluble CD14 Interaction of Neisseria maningitidis with the components of the blood-brain barrier correlates with an increased expression of PilC The Ndomain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae Human microvascular endothelial tissue culture cell model for studying pathogenesis of Brazilian purpuric fever Pseudomonas aeruginosa selective adherence to and entry into human endothelial cells Endothelial function in sepsis 193 Cincomitant endosome-phagosome fusion and lysis of endosomal membranes account for Pseudomonas aeruginosa survival in human endothelial cells Endothelial cell GlcNAc beta 1-4GlcNAc epitopes for outer membrane protein A enhance traversal of Escherichia coli across the blood-brain barrier Escherichia coli invasion of brain microvascular endothelial cells in vitro and in vivo: molecular cloning and characterization of invasion gene ibe10 Characterization of a strain of Chlamydia pneumoniae isolated from a coronary atheroma by analysis of the omp1 gene and biological activity in human endothelial cells Chlamydia species infect human vascular endothelial cells and induce procoagulant activity Signal Transduction Pathways Activated in Endothelial Cells Following Infection with Chlamydia pneumoniae Bartonella (Rochalimaea) quintana endocarditis in three homeless men Bartonella quintana invades and multiplies within endothelial cells in vitro and in vivo and forms intracellular blebs Interaction of Bartonella henselae with endothelial cells results in bacterial aggregation on the cell surface and the subsequent engulfment and internalisation of the bacterial aggregate by a unique structure, the invasome NF-kappa B-dependent inhibition of apoptosis is essential for host cellsurvival during Rickettsia rickettsii infection Rickettsia conorii infection enhances vascular cell adhesion molecule-1-and intercellular adhesion molecule-1-dependent mononuclear cell adherence to endothelial cells IL-6 and IL-8 production from cultured human endothelial cells stimulated by infect on with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi Integrins alpha(v)beta3 and alpha5beta1 mediate attachment of lyme disease spirochetes to human cells Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells Borrelia burgdorferi upregulates the adhesion molecules E-selectin, P-selectin, ICAM-1 and VCAM-1 on mouse endothelioma cells in vitro Characterization of Plasmodium falciparum-infected erythrocyte and P-selectin interaction under flow conditions Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells Secreted aspartyl proteinases and interactions of Candida albicans with human endothelial cells Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis Adhesion molecule expression and lymphocyte adhesion to cerebral endothelium: effects of measles virus and herpes simplex 1 virus Measles virus induction of human endothelial cell tissue factor procoagulant activity in vitro Effects of viral activation of the vessel wall on inflammation and thrombosis Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells Human endothelial cell activation and mediator release in response to the bacterial exotoxins Escherichia coli hemolysin and staphylococcal alpha-toxin Infection by verocytotoxin-producing Escherichia coli Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors Phospholipase C and perfringolysin O from Clostridium perfringens upregulate endothelial cellleukocyte adherence molecule 1 and intercellular leukocyte adherence molecule 1 expression and induce interleukin-8 synthesis in cultured human umbilical vein endothelial cells Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function Pasteurella multocida toxin increases endothelial permeability via Rho kinase and myosin light chain phosphatase Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome The listerial exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C synergize to elicit endothelial cell phosphoinositide metabolism Lipoteichoic acid-induced neutrophil adhesion via E-selectin to human umbilical vein endothelial cells (HUVECs) Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14 but are activated indirectly by peptidoglycan-induced tumor necrosis factor-alpha and interleukin-1 from monocytes Cytokines and endothelial cell biology Cytokine regulation of endothelial cell function: from molecular level to he bedside Pseudomonas siderophore pyochelin enhances neutrophil-mediated endothelial cell injury Superoxide dismutase-dependent, catalase-sensitive peroxides in human endothelial cells infected by Rickettsia rickettsii Superoxide release from interleukin-1B-stimulated human vascular cells: in situ electrochemical measuremeut Lipopolysaccharide enhances oxidative modification of low density lipoprotein by copper ions, endothelial and smooth muscle cells E-selectin expression in human endothelial cells by TNF-alpha-induced oxidant generation and NF-kappaB activation Superoxide responses of endothelial cells to C5a and TNF-alpha: divergent signal transduction pathways Lactosylceramide mediates tumor necrosis factor-alpha induced intercellular adhesion molecule-1 (ICAM-1) expression and the adhesion of neutrophil in human umbilical vein endothelial cells Effect of antioxidants on lipopolysaccharide-stimulated induction of mangano superoxide dismutase mRNA in bovine pulmonary artery endothelial cells Ambient but not incremental oxidant generation effects intercellular adhesion molecule 1 induction by tumour necrosis factor alpha in endothelium ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic Glutathione peroxidase mimics prevent TNFalpha-and neutrophilinduced endothelial alterations Pore-forming bacterial toxins potently induce release of nitric oxide in porcine endothelial cells Cytokine-induced, nitric oxide-dependent, intracellular antirickettsial activity of mouse endothelial cells Endothelial cells are activated by cytokine treatment to kill an intravascular parasite, Schistosoma mansoni, through the production of nitric oxide Escherichia coli endotoxin inhibits agonistmediated cytosolic Ca2 + mobilization and nitric oxide biosynthesis in cultured endothelial cells Expressional control of the constitutive isoforms of nitric oxide synthase (NOS I and NOS III) Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide Nitric oxide donor prevents hydrogen peroxide-mediated endothelial cell injury Nitric oxide attenuates hydrogen peroxide-mediated injury to porcine pulmonary artery endothelial cells Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death Endothelial damage induced by nitric oxide: synergism with reactive oxygen species Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide Halliwell B van d V. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation Lipopolysaccharide induces the antiapoptotic molecules, A1 and A20, in microvascular endothelial cells Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases Oxidant-sensitive and phosphorylation-dependent activation of NF-kappa B and AP-1 in endothelial cells Endothelial activation by hydrogen peroxide. keywords: ach; activation; activity; adherence; adhesion; adp; aeruginosa; alpha; animal; aortic; apoptosis; arteries; aureus; bacterial; barrier; blood; brain; camp; cause; cd14; cells; cellular; coagulation; coli; complex; concentrations; conditions; coronary; cultured; cytokines; damage; dependent; different; dysfunction; edrf; effects; endothelial; endothelial cells; endotoxemia; endotoxin; escherichia; exotoxins; expression; factor; fever; formation; function; gram; group; human; huvec; hydrogen; il-1; increases; induced; infected; infection; inflammatory; inhibition; injury; interaction; intracellular; invasion; isolated; known; leading; leukocyte; levels; lps; lung; microvascular; models; molecule-1; molecules; monocytes; negative; neutrophil; nitrate; nitric; nos; organ; oxide; oxygen; pathways; patients; permeability; plasma; platelet; pneumoniae; porcine; presence; present; process; production; protein; pulmonary; rat; reactive; receptor; regulation; related; relaxation; release; response; results; rickettsia; role; secretion; selectin; sensitive; sepsis; septic; shock; soluble; species; stimulated; stimulation; streptococci; studies; subsequent; superoxide; surface; syndrome; systemic; thrombomodulin; tissue; tnf; toxicity; toxin; transcription; type; vascular; virus; vitro; vivo cache: cord-005872-w1x1i0im.txt plain text: cord-005872-w1x1i0im.txt item: #25 of 105 id: cord-005875-yp1ehpeg author: Zhang, Dong title: Crocin alleviates lipopolysaccharide-induced acute respiratory distress syndrome by protecting against glycocalyx damage and suppressing inflammatory signaling pathways date: 2020-01-10 words: 5144 flesch: 42 summary: In pretreatment with crocin groups, SDC-4 and HS abscission were significantly decreased (Fig. 3a-d) . In the MMP-9 inhib + LPS group, HUVECs were pretreated with 5 µM concentration of MMP-9 inhibitor for 1 h before the LPS (1 µg/mL) stimulation for 6 h. In the CTL inhib + LPS group, HUVECs were pretreated with 10 µM concentration of CTL inhibitor for 1 h before the LPS (1 µg/mL) stimulation for 6 h. In the crocin + LPS group, HUVECs were pretreated with 20 µM concentration of crocin for 1 h before the LPS (1 µg/mL) stimulation for 6 h. Male mice (C57BL/6, 8-9 weeks old, weighing 18-20 g) were purchased from Jinan Animal Feed Center (Shandong, China). keywords: acute; albumin; analysis; anti; ards; assay; cells; complete; concentration; control; crocin; ctl; cultured; damage; degradation; effect; endothelial; erk; experiments; expression; fig; fitc; glycocalyx; group; hmgb1; hpa; huvecs; important; induced; inflammatory; inhibited; inhibitor; injury; iκbα; jnk; lps; lps group; lung; mapk; mice; mmp-9; neutrophil; oxidative; p38; pathway; permeability; phosphorylation; present; pretreatment; protein; pulmonary; results; sections; shedding; stimulated; stimulation; study; transfer; vascular cache: cord-005875-yp1ehpeg.txt plain text: cord-005875-yp1ehpeg.txt item: #26 of 105 id: cord-005980-e2s0racp author: Wu, Xiaojing title: TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury date: 2019-09-05 words: 5217 flesch: 44 summary: 0.05 versus LPS group lung inflammation and apoptosis, which may be associated with decreased NF-κB and JNK activity. We investigated the effects of TIPE2 overexpression on lung cell apoptosis in LPS-challenged mice by TUNEL staining. keywords: aav; activation; activity; acute; administration; ali; alveolar; analysis; anti; antibody; apoptosis; apoptotic; arterial; balf; bax; blood; cells; challenge; changes; collected; control; cytokines; death; effect; expression; factor; fig; group; il-6; inc; induced; inflammation; inflammatory; injury; jnk; levels; lipopolysaccharide; lps; lps group; lung; lung injury; mice; model; mpo; necrosis; nuclear; overexpression; p65; pao; pbs; protein; pulmonary; ratio; serum; staining; study; tipe2; tissues; tnf; treatment; tunel; usa; virus; weight; western cache: cord-005980-e2s0racp.txt plain text: cord-005980-e2s0racp.txt item: #27 of 105 id: cord-006229-7yoilsho author: None title: Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) date: 2016-02-06 words: 134020 flesch: 40 summary: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by a metabolic shift towards enhanced aerobic glycolysis and hence, increased lactate production. Further studies will be performed to clarify whether silver ions and/or silver nanoparticles could affect the specific N-acetylation of arylamines in human cells. keywords: a549; abcb1; absence; absorption; accordance; account; accumulation; acetate; acetylation; acetylcholine; acid; acinar; acinar cells; actin; actions; activation; active; activities; activity; acts; acute; addition; adducts; adenosine; adequate; adhesion; adipocytes; adipose; administration; adp; adrb1; adrenergic; adult; adverse; adverse effects; affected; affinity; agents; aggregation; agonist; ahr; aim; airway; allergic; allosteric; alpha; alterations; altered; alternative; alveolar; amcm; amino; amodiaquine; amounts; analysed; analysis; anesthesia; ang-(1; angiogenesis; angiotensin; animal; antagonist; anti; antibiotics; antibodies; antibody; anticholinergic; antiplatelet; aorta; aortic; apelin; apical; apj; apoptosis; apoptotic; applicability; application; applied; approach; aqueous; area; arginine; arglabin; arrestin; asic3; aspects; assay; assessment; associated; association; at1r; atherosclerosis; atp; atrial; autophagy; available; b2r; b[a]p; background; bacterial; balb; barrier; basal; baseline; basis; baso; battery; bbb; behavior; beneficial; benefit; berlin; best; beta; better; bgn; bid; bile; binding; biochemical; biological; biomarkers; bisphenol; bispyridinium; block; blood; blood cells; blot; blue; bmp2k; body; bone; bpa; bradykinin; brain; breaks; breast; broad; burden; bzw2; c57bl/6; c81; calcium; camp; cancer; cancer cells; candidates; capacity; carcinogenesis; carcinogenic; carcinoma; cardiac; cardiac cells; cardiac function; cardiomyocytes; cardiovascular; care; cascade; cases; cause; cb1; ccmp; ccrcc; cd86; cdt; cell activation; cell culture; cell cycle; cell death; cell line; cell membrane; cell migration; cell model; cell proliferation; cell signaling; cell stress; cell surface; cell transformation; cell type; cell viability; cells; cellular; central; ceo; certain; cgi500; cgmp; chain; challenge; changes; channels; characteristics; characterization; characterized; chemerin; chemical; chemokine; children; chip; choice; cholesterol; chromatography; chronic; chronotropic; cisplatin; cispt; citrate; class; classes; classical; classification; clearance; cleaved; clinical; clom; coa; coated; coculture; cognitive; cohort; collagen; colon; combination; combined; combustion; comet; common; communication; comparable; comparison; compartments; complete; complex; complexes; components; compounds; comprehensive; concentrations; concept; conclusion; conditions; consequences; conserved; consistent; constant; constriction; constructs; consumer; consumption; contact; contaminants; content; contractility; contrast; contribute; contribution; control; conventional; cooh; correlation; corresponding; coupling; course; crem; criteria; critical; cross; crucial; cscc; ctrl; cultivation; culture; cump; current; curves; cxcl12; cxcr4; cycle; cyclic; cyp; cysteine; cytochrome; cytokines; cytometry; cytoskeleton; cytosolic; cytotoxic effects; cytotoxicity; dabigatran; daf-16; daily; damage; data; database; days; ddr; death; decrease; deficient; deficient cells; deficient mice; deficits; degradation; degree; deletion; delivery; dementia; dendritic cells; density; dependent; derivatives; dermal; desvenlafaxine; detail; detailed; detectable; detection; determination; determined; development; dexamethasone; dfg; diabetes; diabetic; diameter; diastolic; diet; dietary; differences; different; different cell; differential; differentiation; difficile; difficult; diffusion; direct; discovery; discussion; disease; disorders; distinct; distribution; dmt; dna; dna damage; dnmt1; domain; dopaminergic; dorsal; dosage; dose; dosing; double; downregulation; downstream; dox; dpat; dpp10; dpra; drg; drug; drug development; duration; dynamic; dysfunction; dyt1; e.g.; early; ecm; effective; effects; efficacy; efficiency; efflux; egf; egfp; ehm; elderly; electrical; electron; electrophysiological; elegans; element; elevated; elisa; embryonic; embryos; endocrine; endogenous; endothelial cells; endothelium; endpoints; energy; engineered; enhanced; enos; entry; environment; enzyme; epac1; epidermal; epidermis; epithelial; epithelial cell; erk1/2; essential; established; esters; estimated; estrogen; eucp; european; evaluated; evaluation; events; evidence; evoked; examination; example; exchange; exhibit; exist; expected; experiments; export; exposure; expression; expression levels; extent; extract; extravasation; eye; faah; factor; failure; family; fatty; fcs; female; ferroptosis; fibroblasts; fibrosis; field; final; findings; fish; flow; fluid; fluorescence; foci; focus; focused; fold; following; food; force; formation; formulations; fraction; frataxin; free; frequency; frequent; fret; function; future; für; g protein; gabaergic; gain; gastric; gastrointestinal; gene; gene expression; general; generation; genetic; genome; genomic; genotoxic; genotoxicity; genotypes; germany; gland; glucose; glutamate; glycidol; goal; good; gpcrs; gradient; great; grk2; group; growth; gtpases; guidelines; gβγ; hacat; hacat cells; hair; half; hand; hazard; hca; hcat-1; health; heart; hek293; hek293 cells; hela; hemin; hepatic; hepatocytes; hepg2; herbal; heterotrimeric; heterozygous; hfd; high; higher; highest; histamine; histological; histone; homeostasis; homoarginine; homozygous; hormone; host; host cells; hours; hplc; hsa; human; human cell; human lung; human skin; huvecs; hypericin; hypertension; hypertrophy; hypochlorite; hypothesis; i.p; ib∆c; icer; idd+ird; identification; igfbp5; il-1β; il-6; il-8; imaging; immature; immune; immunofluorescence; immunohistochemistry; impact; impaired; important; improved; increased; incubation; index; individual; induced; inducible; induction; inflammation; inflammatory; influence; infusion; ingredients; inhalation; inhibited; inhibition; inhibitors; initial; injection; injury; inorganic; inos; insights; institut; insulin; intake; integrity; interaction; interest; interesting; interference; internalization; international; intervention; intestinal; intracellular; intrinsic; introduction; invasive; investigated; investigations; involved; involvement; ird; irritation; isoforms; isolated; isolation; isoproterenol; items; j-82; jaw1; keratinocytes; key; kidney; kinase; kinetics; knockdown; knockout; knowledge; known; laboratory; lack; large; larixyl; laser; lcs; lead; learning; left; leishmania; length; levels; ligand; light; like; likely; limitations; limited; line; linear; link; lipid; liquid; literature; little; liver; living; localization; long; longer; loss; lovastatin; low; lower; lps; luciferase; lung; lung cells; macrophages; major; majority; male; mammalian; manner; mapk; marker; mass; matrix; maturation; max; maximal; maximum; mcpd; mean; measured; measurement; mechanisms; mechanistic; median; mediate; medical; medication; medicine; medium; members; membrane; mesh; messenger; metabolism; metabolites; metabolomics; metformin; methods; methylation; mgmt; mice; microbiome; microrna; microscopy; migration; minor; mir-21; mirnas; mitochondrial; mixture; mmhg; model; moderate; modification; modified; molecular; molecules; monitoring; monocytes; monolayer; months; morphological; morphology; mortality; motor; mouse; mpp22; mrna; mtt; mtx; multiple; muscarinic; muscle; muscle cells; mustard; mutagenic; mutant; mutations; mwcnt; myocardial; n=5; naadp; nacl; nact; nanomaterials; nanoparticles; nat1; natural; nav1.5; necessary; necrosis; need; negative; neonatal; nerve; network; neurodegenerative; neuronal; neurons; new; nmol; non; normal; note; novel; nox; nrf2; nuclear; nuclei; nucleotide; nucleus; number; obesity; objective; observed; occurring; oct1; oecd; offspring; ongoing; onset; open; opioid; option; oral; order; organ; organelles; organic; organisms; outcome; overall; overexpression; overload; oxidation; oxidative; oxide; oxygen; p110γ; p450; p63rhogef; p<0.001; p<0.05; pahs; pain; pancreas; pancreatic; par2; parallel; parameters; parp1; partial; particular; past; patch; pathogenesis; pathological; pathophysiological; pathways; patients; patox; pattern; pde; pdes; pentamers; peptide; performance; period; peripheral; permeability; permeation; pesticides; pharmacokinetic; pharmacological; pharmacology; pharmakologie; phase; phenotype; phosphorylation; physiological; pi16; pie; pigments; pilot; piperacillin; pka; placebo; plant; plasma; platelet; platform; play; pln; pmt; pol; population; position; positive; positive cells; possible; post; postsynaptic; potency; potential; preadipocytes; preclinical; pregnancy; preliminary; preparations; presence; present; present study; pressure; previous; primary; primary cells; primary human; prior; problem; processes; products; profile; profiling; program; progression; project; proliferation; prolonged; promising; promoter; promotion; pronounced; proof; properties; protective; protein; protein expression; protein levels; protocol; pulmonary; purified; purpose; putative; pvat; qpcr; quality; quantification; quantitative; questions; rac1; radiation; range; ranitidine; rapamycin; rapid; rats; reach; reaction; reactive; reason; recent; receptor; receptor activation; receptor potential; receptor protein; recovery; recruitment; reduced; reduction; reference; refinement; regard; regions; regulated; regulation; regulatory; related; relationships; relative; release; relevance; relevant; reliable; remodeling; removal; renal; renin; repair; reported; requirements; research; residues; resistance; resonance; respective; respiratory; response; responsible; results; reticulated; rhoa; rich; rip1; rise; risk; rkip; robust; rock2; rodent; role; root; route; rt-112; s1p; safety; salt; samples; scale; scientific; score; scoring; screening; second; secretion; selected; selection; selective; selectivity; senescence; sensitive; sensitivity; sensitization; sensitizers; sensor; septins; sequence; series; serine; serotonin; serum; set; sets; setup; severe; sham; shift; short; shows; signaling; signals; significance; significantly; silencing; silico; silver; similar; single; single cell; sirna; site; situation; size; skin; skin cells; sleep; slices; slow; sly1; small; smooth; sodium; sources; species; specific; specific expression; specificity; spectrometry; spontaneous; stably; stages; staining; standard; state; statin; statistical; status; stem cells; step; stimulation; strain; strand; strategies; strategy; stress; striatal; strong; stronger; structure; students; studies; study; stw; subsequent; substances; substantial; substrate; subtype; subunit; successful; sufficient; suitable; summary; superoxide; support; surface; survival; symptoms; synaptic; syndrome; synthase; synthesis; synthetic; synuclein; system; systemic; taking; talk; tamoxifen; target; target cells; targeted; targeting; tbhq; tcdb; tcpobop; technique; technology; temperature; terminal; terminus; terms; test; tested; testing; tg mice; therapeutic; therapy; thickness; thp-1; threonine; threshold; thrombin; throughput; time; tissue; tlr2; tmem2; tnf; tnfα; tolerance; tool; total; toxicity; toxicological; toxicology; toxikologie; toxin; tpcs; tps; training; transcription; transduction; transfected; transfer; transformation; transgenic; transgenic mice; transient; translocation; transmission; transport; transporters; transverse; treatment; trials; trpa1; trpc5; trpm3; true; tsh; tumor; tumor cells; turnover; type; type mice; typical; unchanged; underlying; understanding; unique; universität; unknown; untreated; uptake; urinary; urine; useful; validation; values; variants; variety; vascular; veh; vehicle; vein; ventricular; vessels; viability; vimentin; vitro; vivo; voltage; volume; vpa; vs.; water; weeks; weight; welfare; western; wide; wild; wildtype; wnt; women; wood; work; world; wrn; wt mice; wt1; xan; xenobiotic; years; yfp; zebrafish; zolpidem; µor; γh2ax cache: cord-006229-7yoilsho.txt plain text: cord-006229-7yoilsho.txt item: #28 of 105 id: cord-006230-xta38e7j author: None title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. date: 2012-02-22 words: 136000 flesch: 40 summary: In in-vitro studies on rat and canine mast cells and human mast cell leukemia cells HMC1.2 BZ at micromolar concentrations inhibited mediator release which appeared to be related to an inhibition of the intracellular cAMP pathway. Previous work showed that mouse cells lacking the immediate-early gene c-fos are hypersensitive to ultraviolet (UVC) light. keywords: 2007; 24h; 5,6; 72h; a549; abcc2; able; absence; absorption; abundant; ac5; accelerated; accompanied; account; accumulation; acetate; acetyl; acetylcholine; acid; acs; actin; actions; activated; activation; active; activities; activity; acute; addition; adducts; adenosine; adenylyl; adhesion; adipocytes; adipose; administration; adrenergic; adrenergic receptor; adrenoceptor; adult; adverse; adverse effects; affected; affinity; agent; aggregation; agonist; ahr; aif; aim; airway; akt; alanine; alcohol; aldosterone; allergic; alpha; alterations; altered; alternative; alveolar; amino; amounts; ampk; amplitude; analogues; analysis; anandamide; angii; angiogenesis; angiotensin; animals; annexin; antagonists; anti; antibodies; antibody; anticancer; antioxidant; aoh; aortic; apomorphine; apoptosis; apoptotic; application; applied; approach; appropriate; area; arfrp1; arnt; array; arterial; artery; asbestos; asd; assay; assessment; associated; association; assumed; assumption; asthma; atherosclerosis; atp; atrial; attenuated; autophagy; available; average; b cells; background; balb; ballast; barrier; basal; base; basis; bcrp; behavior; best; beta; better; binding; biochemical; biological; biomarkers; biotinylated; bladder; block; blocker; blocking; blood; blood cells; blot; blotting; body; bpde; brain; breaks; breast; brown; c101a; c3bot; c57bl/6; caco-2; cadmium; caf; calcium; calculated; calpain; camp; cancer; cancer cells; candesartan; candidate; capable; capacity; carbon; carcinogenesis; carcinogenic; carcinoma; carcinoma cells; cardiac; cardiomyocytes; cardiovascular; cascade; cases; caspase; catalytic; catalyzed; catechol; cause; cav2.1; cavβ3; ccmp; cd86; cdk5; cdk6; cdna; cdt; celecoxib; cell activation; cell culture; cell cycle; cell death; cell growth; cell line; cell membrane; cell migration; cell proliferation; cell type; cell viability; cells; cellular; central; certain; cfp; cga; cgki; cgmp; chain; challenge; changes; channels; characteristics; characterization; characterized; chemical; chemokine; children; cholesterol; cholinergic; chromatography; chronic; classical; clinical; clopidogrel; cnp; coated; coculture; collagen; colon; column; combination; combined; comet; common; comparable; comparison; compartment; complete; complex; complexes; components; composition; compounds; concentration; concept; concern; conclusion; concomitant; conditions; consequence; conserved; consistent; constitutive; constructs; consumers; consumption; contact; content; contractility; contraction; contrast; contribution; control; control cells; cord; correlation; corresponding; cortex; corticosterone; cosmetic; coupling; course; cox-2; cpg; creb; crem; critical; crucial; cse; ctgf; ctl; culture; cump; current; cx40; cxcr4; cyanamide; cyclase; cycle; cyclic; cyp; cyp1a1; cypa; cytochrome; cytokine; cytometry; cytoskeleton; cytosolic; cytotoxicity; d541a; daily; damage; darc; data; database; days; dcs; death; decreased; deficient; deficient mice; degradation; dehp; deletion; delivery; dendritic cells; density; dental; dependent; dependent cell; dependent protein; derivatives; dermal; detailed; detectable; detection; determination; determined; development; dfg; diabetes; diet; dietary; differences; different; different cell; differential; differentiation; dimerization; diminished; dioxin; direct; discussion; disease; disorder; display; distinct; distribution; diverse; dma; dna; dna damage; domain; dominant; dorsal; dose; double; downregulation; downstream; doxorubicin; drg; drinking; drug; drz; dsbs; dynamics; dyrk1a; dysfunction; dyt1; düsseldorf; e.g.; early; ec50; effective; effects; efficacy; efficient; electrical; electrophilic; elegans; element; elevated; elimination; elisa; embryonic; encoding; endocrine; endocytosis; endogenous; endothelial cells; endpoints; energy; enhanced; enos; environmental; enzymatic; enzyme; eosinophils; ep3; epidemiological; epigenetic; epilepsy; epithelial; er81; erk; erk1/2; erk2; essential; established; estradiol; estrogen; ethanol; evaluation; events; evidence; example; exchange; excretion; exhibit; exon; experimentelle; experiments; exposure; expressed; expression; expression levels; extent; extraction; extracts; extrapolation; factor; failing; failure; family; fast; fat; fatty; features; feeding; female; fibers; fibroblasts; fibrosis; fibrotic; field; findings; flavonoids; flow; fluid; fluorescence; foci; fold; following; food; force; formation; forskolin; fos; foxo4; fraction; free; frequency; fret; function; furthermore; fusion; future; fxa; für; g protein; gain; gel; gene; gene expression; general; generated; generation; genetic; genome; genomic; genotoxic; genotoxicity; genotypes; germany; git1; gland; glioblastoma cells; glioma cells; gls; glucose; glutamate; glutathione; good; gpcrs; gq/11; gradient; grant; grb; great; grk2; grk5; group; growth; gsh; gtpases; guanine; guanylyl; guidance; guinea; gαi2; gαq; gβγ; h2o2; h2r; h4r; h9c2 cells; half; hand; has3; has3v2; hazard; hcc; hcn2; hcn3; hdac; healing; health; heart; heart failure; hek293 cells; hela cells; helenalin; hema; hepatic; hepatoma cells; hepg2; hepg2 cells; herbal; heterologous; heterotrimeric; high; higher; histamine; hivep1; homeostasis; homologous; hormone; hours; hplc; hprt; ht1a; ht2a; human; human cells; human exposure; human heart; human liver; human lung; hur; hyaluronan; hydralazine; hydrogen; hyo; hypertension; hypertrophy; hypothesis; ic50; icer; identification; iii; il-1β; il-4; il-6; il-8; imaging; immune; immune cells; immunoprecipitation; impact; impaired; impairment; important; important role; improved; inactive; increased; incubated; incubation; individual; induced; inducible; induction; infants; inflammation; inflammatory; inflammatory cells; influence; influx; inhalation; inhibited; inhibition; inhibitors; initial; injection; injury; inos; insights; insp3r; institut; insulin; intact; intact cells; intake; integrity; interaction; interest; interesting; internalization; intervention; intestinal; intracellular; intrinsic; introduction; investigation; involved; involvement; irag; ischemic; isoforms; isolated; isolation; isoprenaline; jnk; keratinocytes; key; kibra; kidney; kinase; kinetics; klinische; knockdown; knockout; knowledge; known; ksrp; lack; large; laser; lat1; leads; learning; left; leipzig; length; lesions; leukemia; levels; library; ligand; like; likely; limited; line; linear; link; lipid; liquid; literature; littermates; little; liver; living; living cells; localization; long; loop; loss; lov; low; lower; lps; luciferase; lung; lymph; lysates; macrophages; mainz; major; male; mammalian; mammalian cells; mammary; manner; mapk; marker; mass; mast; mast cells; matrix; maturation; maximal; maximum; mda; means; measurements; mechanical; mechanisms; mecp2; mediate; mediators; medical; medicinal; medium; melanoma cells; members; membrane; membrane potential; memory; mesangial cells; messenger; met-5a cells; metabolism; metabolites; methods; methylation; mice; microarray; microglial; micrornas; microscopy; migration; milk; minipigs; minor; minutes; mirnas; mitochondrial; mixtures; model; modifications; modified; modulate; modulation; molecular; molecules; monitoring; monomers; months; morphology; mortality; motility; mouse; mrna; mtt; mtx; multiple; murine; muscarinic; muscle cells; mutagenic; mutant; mutated; mutations; mycotoxin; myeloid; myocardial; myosmine; myricetin; münchen; münster; n=3; n=4; nadph; nanomaterials; nanoparticles; nat1; natural; ndpk; necessary; need; negative; neonatal; nerve; nervous; network; neuroblastoma; neuronal; neuronal cells; neurons; neuropathic; neutrophils; new; nfat; nitric; noaels; nociceptive; non; noradrenaline; normal; novel; nox4; nrf2; nuclear; nucleotide; nucleus; number; numerous; oat2; observed; oecd; oil; olesoxime; ongoing; onset; open; opioids; oral; order; organic; organism; organs; origin; overall; overexpression; overload; oxidase; oxidation; oxidative; oxide; oxygen; p110γ; p2x7; p38; p450; p53; p63rhogef; p<0.05; pacing; pain; par-2; parallel; parameters; parp; particular; pasireotide; patch; pathogenesis; pathological; pathophysiology; pathway; patients; pattern; pcb; pcls; pcr; pde10; pde2a; pde4; pdgf; peak; peptide; period; peripheral; permeability; pfoa; pharmacokinetics; pharmacological; pharmacology; pharmakologie; phase; phenotype; phosphatase; phosphodiesterases; phospholamban; phospholipase; phosphorylation; physiological; pi16; pi3k; pimecrolimus; pka; pkc; pkgi; placebo; placenta; plant; plasma; plasmin; platelet; plcγ2; pln; plus; pma; pmt; point; polarized; poly(adp; polymerase; polyphenols; poorly; pore; positive; possible; post; postsynaptic; potassium; potency; potential; pparγ; ppd; preparations; presence; present; present study; pressure; previous; primary; primary cells; prior; procedure; processes; processing; production; products; profile; progression; project; proliferation; prominent; promising; promoter; pronounced; properties; protease; protective; protein; protein activation; protein expression; protein kinase; protein levels; protocol; proximal; pulmonary; purified; putative; pxr; qpcr; qrt; quality; quantification; quantitative; question; rabbit; rac1; radiation; range; rapid; rats; reach; reaction; reactive; recent; receptor; receptor activation; receptor potential; receptor protein; recombinant; redox; reduced; reference; regard; region; regulated; regulation; regulatory; related; relative; relaxation; release; relevance; relevant; remodeling; renal; repair; replacement; reported; research; residues; resistance; respect; respective; respiratory; response; responsible; results; resveratrol; reticulum; retigabine; rhoa; rhob; rhogef17; rhoh; right; risk; rkip; robust; rodents; role; root; ros; s. 1; s1p; s49; sac; safety; samples; sclc cells; screening; second; secondary; secretion; selected; selective; sensitive; sensitivity; sensitization; sensor; separated; separation; sept4; sequence; series; serine; serum; set; severe; sex; shock; short; shortening; signaling; signals; significant; silencing; silver; similar; single; sirna; sirt1; site; situation; size; skeletal; skin; slc2a9; slices; small; smc; smf; smooth; soat; soce; sodium; soluble; solution; somatostatin; sources; special; species; specific; specific expression; specificity; spectrometry; spectrum; sperm; sphk-1; spinal; spontaneous; src; sst2; sst5; stability; stable; stages; staining; standard; state; status; stem cells; step; steroid; stimulated; stimulation; stimulatory; stimuli; strand; strategies; strategy; straße; streptavidin; stress; strex; strong; structural; students; studies; study; stw; subcellular; subject; subsequent; substances; substrate; subtypes; subunits; suitable; sulfate; summary; superoxide; support; suppression; surface; survival; syndrome; synthesis; synthetic; system; systemic; t cells; tak1; tandem; target; target cells; targeting; tcdd; techniques; telmisartan; tempol; terminal; terminus; test; tested; testing; testis; tgf; therapeutic; therapy; thr188; threonine; threshold; thrombin; throughput; time; tissue; tmc8; tmem2; tmz; tnf; tnfα; tone; tool; top2b; total; toxic effects; toxicity; toxicological; toxicology; toxikologie; toxin; tpc1; transcription; transcripts; transduction; transfer; transformation; transgenic; transgenic mice; transient; translocation; transmembrane; transplantation; transport; transporters; treatment; trials; triple; trpa1; trpc6; trpm3; trpv5; ttc; tumor; tumor cells; turn; type; type mice; typical; tyrosine; unchanged; unclear; underlying; understanding; understood; universität; unknown; untreated; untreated cells; uptake; useful; utp; uvb; v79 cells; values; variants; variety; vascular; vasoconstriction; vasodilator; vector; ventilation; ventricular; vessel; viability; vitamin; vitro; vivo; voltage; volume; volunteers; vsmc; water; weekly; weeks; weight; western; white; wide; wild; wildtype; women; work; wound; würzburg; years; zebrafish; zen; zno; µmol; α2a; βar; γh2ax cache: cord-006230-xta38e7j.txt plain text: cord-006230-xta38e7j.txt item: #29 of 105 id: cord-006279-ib5z3elq author: Ryter, Stefan W. title: Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance date: 2002 words: 8196 flesch: 38 summary: The role of inorganic metals and metalloporphyrins in the induction of haem oxygenase and heat-shock protein 70 in human hepatoma cells Cadmium-induced mRNA expression of Hsp32 is augmented in metallothionein-I and -II knock-out mice Co-regulation of heme oxygenase and erythropoietin genes Regulation of heme oxygenase gene expression by cobalt in rat liver and kidney Dual control mechanism for heme oxygenase: Tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver Regulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tin-protoporphyrin Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38 Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors Nitric oxide-inducible expression of heme oxygenase-1 in human cells. In isolated perfused rat liver, ZnPPIX diminished CO levels detectable in the effluent, and increased the perfusion pressure under the constant flow conditions. keywords: accumulation; activation; activity; anti; biliverdin; binding; brain; carbon; cdcl; cells; cellular; cgmp; chronic; conditions; cultured; cyclase; cytochrome; cytokines; degradation; dependent; effects; elevation; endogenous; endothelial; enzymes; erk; evidence; exposure; expression; factor; fibroblasts; form; gas; gene; gsh; guanylate; heat; heme; heme oxygenase-1; hepatic; high; ho-1; ho-2; human; hyperoxia; hypoxia; increased; induced; inducible; induction; inflammatory; inhibited; inhibitor; injury; intracellular; iron; ixα; kinase; levels; liver; lps; lung; mapk; mechanism; metals; mice; mitogen; mkk3; model; modulation; monoxide; mrna; muscle; nitric; nos; overexpression; oxidative; oxygenase-1; p-450; p38; pathways; possible; ppm; presence; production; proliferation; properties; protein; pulmonary; rat; raw; recent; regulation; regulatory; relative; response; role; sgc; shock; signaling; significance; smooth; stress; studies; system; tnfα; transcription; transduction; treatment; type; vascular; vivo; vsmc; wild cache: cord-006279-ib5z3elq.txt plain text: cord-006279-ib5z3elq.txt item: #30 of 105 id: cord-006285-kkxdmzk9 author: Smirnova, S. S. title: Long-Term Maintenance of the Functional Changes Induced by Influenza A Virus and/or LPS in Human Endothelial ECV-304 Cell Sublines date: 2019-08-26 words: 4695 flesch: 33 summary: An increase in endothelial cell migration in the presence of bacterial lipopolysaccharide (LPS) is used as an indicator of the conversion of endothelial cells into activated fibroblasts via the endothelial to mesenchymal transition (Sarmiento et al., 2014) . It has been demonstrated that, in the course of long-term culturing (six passages) after exposure to pathogenic agents (influenza virus and/or LPS), endothelial cells maintain changes in their migratory activity, permeability, and expression of mRNA for cytokines TNFα and TGFβ (along with the changes in their proliferation activity, which has been demonstrated earlier). keywords: activity; alpisarin; analyzed; angiogenesis; antiviral; apoptosis; barrier; case; cell sublines; cells; changes; control; cytokines; development; doses; ecv-1000id; ecv-1id; ecv-304; endothelial; endothelial cells; et al; exposure; expression; functional; high; human; increase; infection; influenza; influenza virus; level; low; lps; migration; migratory; mrna; nox4; passage; permeability; preparations; proliferation; result; rimantadine; sixth; smirnova; sublines; surface; tgfβ; time; tnfα; vascular; virus; work; wound cache: cord-006285-kkxdmzk9.txt plain text: cord-006285-kkxdmzk9.txt item: #31 of 105 id: cord-006318-9r51n241 author: Sideras, Paschalis title: Activin, neutrophils, and inflammation: just coincidence? date: 2013-02-06 words: 12977 flesch: 25 summary: Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis Elevated levels of activin A in heart failure: potential role in myocardial remodeling Activin and related proteins in inflammation: not just interested bystanders Activin A/ erythroid differentiation factor is induced during human monocyte activation Regulation of production of activin A in human marrow stromal cells and monocytes Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide Microglial cells and peritoneal macrophages release activin A upon stimulation with Toll-like receptor agonists Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production Production and function of activin A in human dendritic cells Induced expression of the new cytokine, activin A, in human monocytes: inhibition by glucocorticoids and retinoic acid Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages A dual role of activin A in regulating immunoglobulin production of B cells Tumour necrosis factor-alpha stimulates human neutrophils to release preformed activin A Regulation of activin A release from murine bone marrowderived neutrophil precursors by tumour necrosis factor-alpha and insulin Acute regulation of activin A and its binding protein, follistatin, in serum and tissues following lipopolysaccharide treatment of adult male mice Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14 The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells Induction of prostanoid, nitric oxide, and cytokine formation in rat bone marrow derived macrophages by activin A Activin A and retinoic acid synergize in cyclooxygenase-1 and thromboxane synthase induction during differentiation of J774.1 macrophages A critical role of activin A in maturation of mouse peritoneal macrophages in vitro and in vivo Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells Activin A induces Langerhans cell differentiation in vitro and in human skin explants Activin A down-regulates the phagocytosis of lipopolysaccharideactivated mouse peritoneal macrophages in vitro and in vivo Inhibitory effect of activin A on activation of lipopolysaccharidestimulated mouse macrophage RAW264.7 cells Activin A regulates the production of mature interleukin-1beta and interleukin-1 receptor antagonist in human monocytic cells Activin as an anti-inflammatory cytokine produced by microglia Regulation of activin A synthesis in microglial cells: pathophysiological implications for bacterial meningitis Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers Activin a promotes the TGF-beta-induced conversion of CD4+ CD25− T cells into Foxp3+ induced regulatory T cells Activin-A attenuates several human natural killer cell functions Further characterization of activin Ainduced IgA response in murine B lymphocytes Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF Stimulatory effects of lipopolysaccharide on endothelial cell activin and follistatin Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells Serum growth factors and proinflammatory cytokines are potent inducers of activin expression in cultured fibroblasts and keratinocytes The role of the host defence response in the progression and outcome of ARDS: pathophysiological correlations and response to glucocorticoid treatment ARDS and the multiple organ dysfunction syndrome. Given their direct involvement in safeguarding and remediating homeostasis, such a relationship is most likely anything but coincidental. Mechanisms of TGF-beta signaling from cell membrane to the nucleus Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid Insertion of Inhbb into the Inhba locus rescues the Inhbanull phenotype and reveals new activin functions Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm Regulation of prostate branching morphogenesis by activin A and follistatin Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice Inhibins, activins and follistatin: actions on the testis Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival The transforming growth factor-beta family Regulation of activin's access to the cell: why is mother nature such a control freak Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice Molecular cloning of the mouse activin beta E subunit gene Cloning of a new member of the TGF-beta family: a putative new activin beta C chain Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins Functional analysis of activins during mammalian development Beta A versus beta B: is it merely a matter of expression? Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly Smad regulation in TGF-beta signal transduction Non-Smad TGF-beta signals Both SMAD2 and SMAD3 mediate activinstimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells Activin B can signal through both ALK4 and ALK7 in gonadotrope cells Smad3 mediates activin-induced transcription of follicle-stimulating hormone beta-subunit gene The biology of activin: recent advances in structure, regulation and function Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A Requirement for activin A and transforming growth factor-beta 1 pro-regions in homodimer assembly Monomeric activin A retains high receptor binding affinity but exhibits low biological activity A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands Activin A binds to perlecan through its proregion that has heparin/heparan sulfate binding activity Growth factor binding to the pericellular matrix and its importance in tissue engineering New insights into the mechanisms of activin action and inhibition The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice Expression cloning of an activin receptor, a predicted transmembrane serine kinase FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family Follistatin-related protein (FSRP): a new member of the follistatin gene family Antagonists of activin signaling: mechanisms and potential biological applications Activin-binding protein from rat ovary is follistatin Structural basis for the inhibition of activin signalling by follistatin Primary structure of the human follistatin precursor and its genomic organization A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. keywords: action; activated; activation; activin; activities; activity; acute; adaptive; adenovirus; administration; affinity; airway; allergen; allergic; alveolar; animals; anti; ards; asthma; balance; beta; binding; biological; bone; capacity; cause; cells; cells activin; coagulation; collateral; complex; context; control; cytokine; damage; days; dcs; death; development; different; differentiation; disease; earlier; early; effect; epithelial; expression; extracellular; factor; family; fibroblasts; fibrosis; fig; follistatin; forms; function; gene; growth; high; hmgb1; homeostasis; human; ifn; il-1β; il-6; immune; immunity; important; increase; induced; induction; inflammation; inflammatory; inhibin; injury; innate; involvement; levels; ligands; like; lps; lung; macrophages; marrow; mechanisms; mice; molecules; mouse; mrna; murine; muscle; negative; nets; neutralization; neutrophils; new; numerous; observations; ova; overexpression; pathology; pathophysiology; patients; peritoneal; phenotype; production; proliferation; protein; rat; receptors; regulatory; related; relationship; release; remodeling; repair; respiratory; response; role; secretion; sepsis; serum; severe; signaling; skin; specific; stimulation; studies; study; subunits; super; syndrome; system; systemic; tgf; therapeutic; tissue; tnf; transgenic; transient; treatment; type; upregulation; vivo cache: cord-006318-9r51n241.txt plain text: cord-006318-9r51n241.txt item: #32 of 105 id: cord-006570-v4as5gde author: Sukhotnik, Igor title: Oral Insulin Up-regulates Toll-like Receptor 4 Expression and Enhances Intestinal Recovery Following Lipopolysaccharide-induced Gut Injury in a Rat date: 2007-10-13 words: 4079 flesch: 39 summary: Following pretreatment with oral insulin (group C), LPS rats showed a significant decrease in apoptotic index in ileum (1.4 ± 0.2 vs. 2.3 ± 0.3 apoptotic cells per 10 villi, P \ 0.05) compared to LPS-animals (group B), and tendency toward decrease in cell apoptosis in jejunum; however, this trend did not achieve statistical significance. LPS rats demonstrated 50% increase in TLR4 expression in jejunum compared to sham animals. keywords: administration; animals; apoptosis; apoptotic; bacterial; bowel; cell; changes; crypt; damage; data; decrease; depth; dna; effect; endotoxemia; enterocyte; experimental; expression; failure; gene; group; growth; gut; ileal; ileum; immune; increase; index; injection; injury; insulin; intestinal; jejunum; like; lipopolysaccharide; lps; mucosal; multiple; oral; organ; present; proliferation; protein; proximal; rats; receptor; recovery; response; sham; significant; small; studies; study; tissue; tlr4; toll; villus; weight cache: cord-006570-v4as5gde.txt plain text: cord-006570-v4as5gde.txt item: #33 of 105 id: cord-006605-tsk3pakb author: Jesmin, Subrina title: Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury date: 2006-11-30 words: 4514 flesch: 40 summary: key: cord-006605-tsk3pakb authors: Jesmin, Subrina; Gando, Satoshi; Zaedi, Sohel; Sakuraya, Fumika title: Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury date: 2006-11-30 journal: Inflammation DOI: 10.1007/s10753-006-9017-8 sha: doc_id: 6605 cord_uid: tsk3pakb The hypothesis that the expression of protease-activated receptors (PARs) protein is regulated at the level of transcription and that PAR isoforms, PAR-1, PAR-2, PAR-3, and PAR-4, in lung tissue show different patterns of expression in lipopolysaccharide (LPS)-induced acute lung injury (ALI) was tested. We examined the expression of protein and mRNA and the immunohistochemical localization of PAR isoforms in lung tissues 1, 3, 6, and 10 h after LPS administration. keywords: activation; acute; addition; administration; ali; alveolar; anti; antibodies; antibody; blood; cells; coagulation; control; deposition; distinct; distribution; endothelium; epithelium; expression; factor; fibrin; fig; human; immunoreactivity; increase; induced; inflammation; injury; isoforms; levels; lps; lps administration; lung; macrophages; mouse; muscle; par; par-2; pars; pathogenesis; present; protease; protein; pulmonary; rats; receptors; role; sections; similar; sized; smooth; staining; strong; study; thrombin; time; tissue; tnf; transcription; vascular; vessels cache: cord-006605-tsk3pakb.txt plain text: cord-006605-tsk3pakb.txt item: #34 of 105 id: cord-006700-df8ard9o author: Müller-Redetzky, Holger C. title: Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives date: 2014-03-06 words: 10653 flesch: 18 summary: For example, cell wall peptidoglycan of Streptococcus pneumoniae activates TLR-2 (Schroder et al. 2003) , while the pneumococcal exotoxin pneumolysin is recognized by TLR-4 and NLRP-3 (Malley et al. 2003; Witzenrath et al. 2011) . Pneumolysin, for example, may rapidly induce (1) Ca 2+ influx and (2) liberation of platelet activating factor (PAF) followed by thromboxane release (Lucas et al. 2012; Witzenrath et al. 2007 ). keywords: actin; activation; activity; acute; acute lung; addition; adhesion; adrenomedullin; alpha; alveolar; ards; bacterial; barrier; blocking; blood; c3a; c5a; cadherin; cascades; cells; cellular; central; ceramide; clinical; coagulation; complement; complex; concentrations; contraction; dependent; development; different; disease; disruption; distress; dysfunction; ecs; effects; endothelial; endothelial barrier; endothelial cells; endothelial permeability; endotoxin; epithelial; et al; experimental; expression; extracellular; factor; failure; formation; fty720; function; generation; high; human; hyperpermeability; imatinib; immune; important; increase; infection; inflammation; inflammatory; inhaled; inhibition; injury; innate; integrity; ischemia; junctions; kinase; leading; leads; leakage; leukocyte; levels; like; lps; lung; lung injury; mechanical; mechanisms; mediates; mediators; mice; microvascular; mlck; models; molecules; monocytes; mortality; murine; myosin; neutrophils; nitric; oedema; oxide; oxygen; paf; paracellular; pathway; patients; permeability; phosphate; phosphorylation; plasma; platelets; pneumolysin; pneumonia; potential; production; protein; pulmonary; reactive; receptor; recruitment; reduced; regulation; related; release; reperfusion; respiratory; response; rhoa; rns; role; ros; s1p; s1p1; sepsis; severe; signaling; soluble; species; specific; sphingosine; staphylococcus; stimulation; stress; studies; suttorp; syndrome; systemic; therapeutic; thrombin; thromboxane; tie2; tlr4; tnf; toll; treatment; vascular; vascular permeability; ventilator; vitro; vivo cache: cord-006700-df8ard9o.txt plain text: cord-006700-df8ard9o.txt item: #35 of 105 id: cord-006778-qnxyhmw5 author: Chen, Xuxin title: Downregulation of Paralemmin-3 Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Rats by Regulating Inflammatory Response and Inhibiting Formation of TLR4/MyD88 and TLR4/TRIF Complexes date: 2017-08-12 words: 8546 flesch: 50 summary: However, the downregulation of PALM3 did impact the upregulation of TLR4, MyD88, and TRIF protein expression induced by LPS in rat lung tissues. In the present study, we found that the downregulation of PALM3 suppressed NF-κB-DNA-binding activity and decreased NF-κB phospho-p65 and phospho-IRF3 protein levels in the nucleus of ALI rat lung tissues. keywords: actin; activation; activity; acute; ad.palm3; ad.v; ad.v group; adaptors; ali; analysis; anti; antibody; ards; balf; beyotime; cat; cells; china; co.; control; cytokine; dependent; downregulation; dry; edema; effect; expression; factor; fig; formation; gene; group; ifn; important; induced; infiltration; inflammation; inflammatory; inhibition; injury; irf3; levels; like; lipopolysaccharide; lps; lung; lung injury; mechanisms; membrane; mice; model; mpo; myd88; negative; neutrophil; normal; nuclear; p65; palm3; palm3 expression; pathway; phospho; point; present; previous; protein; pulmonary; rate; rats; receptor; regulatory; research; response; results; serum; shrna; sigirr; signaling; socs3; stimulation; studies; study; survival; tbst; time; tissues; tlr4; toll; total; transcription; transduction; treatment; trif; western; wet cache: cord-006778-qnxyhmw5.txt plain text: cord-006778-qnxyhmw5.txt item: #36 of 105 id: cord-006888-qfnukav4 author: None title: Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008 date: 2008-10-21 words: 30386 flesch: 51 summary: We determined the frequency of HSV-1 in COPD patients (stable and exacerbated) and if it was associated with disease severity and mortality. Methods: Stable and exacerbated COPD patients were recruited. keywords: a1at; aat; aatd; ability; abnormal; access; active; activities; activity; acute; adenosine; admissions; aecopd; aeruginosa; age; ahi; aim; airway; alpha-1; analysis; antibiotic; antibody; anxiety; appropriate; assessment; associated; asthma; asthmatic; audit; available; average; bacterial; ban; baseline; belfast; beta; biopsy; blood; bmi; body; bronchial; bronchiectasis; bronchoscopy; bts; cancer; capacity; cardiac; care; cases; cause; cells; cf patients; changes; chest; children; chronic; clinical; cohort; combination; common; community; compliance; conclusion; conditions; confirmed; control; copd; copd patients; correlation; cough; cpap; cpet; criteria; crp; cse; culture; current; cystic; data; days; death; decrease; deficiency; dependent; development; diabetic; diagnosis; differences; disease; dose; drains; drug; duration; early; education; effect; effective; elevated; endurance; eosinophil; epithelial; eus; evidence; exacerbations; exercise; experience; exposure; expression; factors; failure; female; fev1; fibrosis; findings; fna; following; free; function; general; group; guidelines; health; high; higher; highlights; history; home; hospital; hypertonic; igg; il-8; impact; important; improved; incidence; increased; index; individuals; induced; infection; inflammation; inflammatory; information; inhaled; initial; injury; international; intervention; interviews; invasive; involvement; ipf; ireland; irish; isolates; issues; knowledge; known; large; levels; life; limited; liver; living; ll-37; long; lower; lpa; lps; lung; lung cancer; macrophages; major; male; management; mass; mds; mean; measure; median; medical; membrane; methods; months; morbidity; mortality; muscle; n =; national; need; negative; neutrophil; niv; non; normal; number; nurse; obstructive; old; omalizumab; osa; osas; outcome; outpatient; overall; oxygen; p =; pack; palliative; pathway; patients; pcr; period; players; pleural; pneumonia; poor; population; positive; post; potential; practice; prescribed; presence; present; pressure; prevalence; primary; prior; procedure; programme; prophylaxis; protein; pulmonary; quality; questionnaire; radiation; range; rate; receptor; recurrent; reduction; referrals; regulation; rehabilitation; related; release; report; research; resistant; respiratory; response; results; retrospective; review; risk; role; s1p; saline; samples; sarcoidosis; score; screening; second; serum; service; severe; severity; shr; shuttle; significant; similar; sleep; slpi; small; smokers; smoking; society; specialist; spirometry; sputum; stable; staging; standard; status; stay; strategy; studies; study; subjects; support; surgical; survey; symptoms; syndrome; system; tbna; term; test; testing; therapy; thoracic; time; tlc; total; treatment; tuberculosis; type; ultrasound; underwent; unit; use; vitamin; ward; weeks; western; years cache: cord-006888-qfnukav4.txt plain text: cord-006888-qfnukav4.txt item: #37 of 105 id: cord-007178-h0ordzm9 author: Felts, Paul A. title: Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide date: 2005-05-04 words: 9522 flesch: 41 summary: LPS injection markedly increased such labelling, and by 4 h after LPS injection labelling had increased in both the number of labelled vessels and the apparent intensity of labelling (Fig. 6C) . At 14 days after LPS injection, the axons in lesions from dexamethasonetreated animals tended to be surrounded by whorls of myelin debris, whereas naked demyelinated axons, or demyelinated axons associated with cell processes, were particularly common in LPS lesions from saline-treated animals. keywords: activation; acute; adjacent; animals; antibody; appearance; area; arrows; astrocytes; axons; blood; brain; cells; cns; column; cord; damage; days; debris; deep; demyelinated; demyelination; dexamethasone; dilution; dorsal; dorsal funiculus; early; ed1; electron; endotoxin; et al; examined; expression; extracellular; factor; fig; funiculus; gfap; grey; icam-1; il-1b; induced; inflammation; inflammatory; injection; inos; labelling; large; left; lesion; light; like; lipopolysaccharide; loss; lps; lps injection; lymphocytes; macrophages; matter; microglia; microscopy; multiple; n =; normal; number; observed; oligodendrocytes; parenchyma; pmns; positive; positive cells; present; primary; processes; prominent; rat; receptor; region; response; result; saline; schwann; sclerosis; sections; sigma; similar; site; small; spinal; studies; substantial; time; tissue; tlr4; treatment; vessels; virus; white cache: cord-007178-h0ordzm9.txt plain text: cord-007178-h0ordzm9.txt item: #38 of 105 id: cord-009753-6rg47f0i author: Legband, Nathan title: The Treatment of Acute Respiratory Distress Syndrome in Rats With a Peritoneal Dosing System date: 2015-06-01 words: 1278 flesch: 47 summary: Chest radiographs taken of LPS rats show clear indications of bilateral infiltrates and interstitial edema in the lungs (Fig. 1) . Once the prototype of the PDS has been constructed, tests will be completed with healthy rats to validate the system and provide the rat with full mobility. keywords: acute; animal; ards; blood; cavity; current; design; distress; injury; lps; lung; models; ombs; oxygen; oxygenation; pds; peritoneal; phase; pmo; rats; respiratory; system; treatment; trials cache: cord-009753-6rg47f0i.txt plain text: cord-009753-6rg47f0i.txt item: #39 of 105 id: cord-011286-8wxih7v6 author: You, Qinghai title: MiR-802 alleviates lipopolysaccharide-induced acute lung injury by targeting Peli2 date: 2019-11-06 words: 4631 flesch: 47 summary: Therefore, we concluded miR-802 expression may antagonize proinflammatory cytokine production during LPSmediated lung inflammatory response and tissue damage. However, miR-802 expression did not change the LPS effect on cell apoptosis. keywords: activation; activity; acute; alveolar; analysis; animal; ards; assay; cancer; cells; challenge; control; cytokine; damage; distress; downstream; effect; epithelial; expression; factor; fig; group; human; inflammation; inflammatory; injury; kit; level; lps; luciferase; lung; lung injury; macrophages; mice; mir-802; mir802; mirna; model; mouse; nlrp3; novel; pathogenesis; pathway; patients; peli2; primary; production; protein; respiratory; response; role; scramble; sepsis; study; suppression; syndrome; target; therapeutic; tissue; tlr4; tnfα; treatment; vivo cache: cord-011286-8wxih7v6.txt plain text: cord-011286-8wxih7v6.txt item: #40 of 105 id: cord-012487-s920s5wb author: Noga, Marek J. title: Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli date: 2020-08-18 words: 7489 flesch: 39 summary: Trends in PL abundance, PL flux, ACP species, PL intermediates, and PL synthesis enzyme concentrations in ppGpp-limited cultures closely followed the trends observed when was adjusted by carbon source (Fig. 1B , C, and E to G) (see also Fig. As PL synthesis flux has been observed to oscillate with the cell division cycle in E. coli and other bacteria (46) , PlsB may also be regulated by the divisome or by septum formation. keywords: acc; acetyl; acid; acp; activity; acyl; addition; analysis; biosynthesis; buffer; c14:0; carbon; cell; changes; coa; coli; concentrations; conditions; consistent; control; culture; data; decrease; effects; enzyme; escherichia; fatty; fatty acid; fig; flux; fold; g3p; growth; high; increase; incubation; inhibition; intermediates; levels; long; lps; lpxc; malonyl; max; medium; membrane; min; model; mupirocin; observed; pathway; phosphate; phospholipid; pl flux; pl synthesis; plsb; posttranslational; ppgpp; protein; rate; regulated; regulation; rela; response; samples; size; species; state; steady; strain; substrate; synthesis; table; transcriptional; trends; type; vol; volume; wild cache: cord-012487-s920s5wb.txt plain text: cord-012487-s920s5wb.txt item: #41 of 105 id: cord-012791-dyk5mr1q author: Zheng, Yong title: Icariside II inhibits lipopolysaccharide-induced inflammation and amyloid production in rat astrocytes by regulating IKK/IκB/NF-κB/BACE1 signaling pathway date: 2019-09-25 words: 4165 flesch: 39 summary: However, ICS II abolished these changes, suggesting that ICS II exerts potent antiinflammatory effects, at least partly through modulating the IKK/IκB/NF-κB pathway. Primary rat astrocytes were pretreated with ICS II (5, 10, and 20 μM) or dexamethasone (DXMS, 1 μM) for 1 h, thereafter, treated with LPS for another 24 h. We found that ICS II pretreatment dose dependently mitigated the levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) in the astrocytes. keywords: activation; alzheimer; amyloid; anti; antiinflammatory; app; astrocytes; bace1; beta; brain; cells; cognitive; concentration; cultured; disease; dxms; effect; elisa; expression; factors; fig; icariside; ics; ics ii; ikk; il-1β; induced; inflammatory; inos; iκb; levels; lipopolysaccharide; lps; microglia; neuroinflammation; neuronal; nitric; oxide; p65; pathway; previous; primary; production; protein; rats; results; role; secretase; signaling; studies; study; tnf cache: cord-012791-dyk5mr1q.txt plain text: cord-012791-dyk5mr1q.txt item: #42 of 105 id: cord-012828-wsjob1p8 author: Wang, Yan-hang title: Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway date: 2019-09-10 words: 4234 flesch: 36 summary: Recently, dopamine receptors have been found to be involved in multiple immunopathological processes and considered as valuable therapeutic targets for inflammation-associated neurologic diseases. By using transcriptomics coupled with bioinformatics analysis, we revealed that isosibiricin treatment mainly affect dopamine receptor signalling pathway. keywords: activation; addition; analysis; anti; balb; beijing; bv-2; caspase-1; cells; china; control; dependent; disease; dopamine; drd1; drd2; effect; experiments; expression; fig; genes; group; il-1β; il-6; inflammasome; inflammasome pathway; inflammatory; inhibited; inhibition; inhibits; isosibiricin; kit; lipopolysaccharide; lps; mechanism; mice; multiple; neuroinflammation; neurological; nigericin; nlrp3; pathway; potential; pro; production; protein; receptor; relative; response; reverse; sch; specific; study; sultopride; targets; therapeutic; tnf; treatment; upregulated cache: cord-012828-wsjob1p8.txt plain text: cord-012828-wsjob1p8.txt item: #43 of 105 id: cord-013067-sic08gsg author: Turzo, Maurizio title: Inhibition of overexpressed Kv3.4 augments HPV in endotoxemic mice date: 2020-10-08 words: 4410 flesch: 45 summary: Since LPS induced PKC in vitro within 6 h in mouse microglia [31] and after 12 h in mouse lungs [32] , it is possible that not only the number of Kv3.4 channels is increased by LPS, but also the amount of open channels. In summary, endotoxemia induces in mouse lungs expression of Kv3.4. keywords: acute; aldrich; animals; anti; arteries; artery; bds; cells; channels; control; data; endotoxemic; expression; fig; flow; gene; germany; group; heidelberg; hpv; human; hypoxic; i.p; increase; induced; inhibition; isolated; kv2.1; kv3.4; kv6.3; lps; lungs; mice; min; mmhg; mouse; muscle; nacl; nitric; oxide; pap; patients; perfusate; perfusion; pkc; potassium; pressure; protein; pulmonary; rabbit; results; role; selective; sem; sensitive; sigma; smooth; solution; specific; study; tissue; usa; vascular; vasoconstriction; voltage; weight; δpap cache: cord-013067-sic08gsg.txt plain text: cord-013067-sic08gsg.txt item: #44 of 105 id: cord-013366-sbdtpsz6 author: Ramírez-Pérez, Sergio title: Downregulation of Inflammatory Cytokine Release from IL-1β and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor date: 2020-09-21 words: 5782 flesch: 37 summary: The interleukin (IL)-1 cytokine family-Balance between agonists and antagonists in inflammatory diseases Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway Peptide-mediated interference of TIR domain dimerisation in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation Disrupting myddosome assembly in diffuse large B-cell lymphoma cells using the MYD88 dimerisation inhibitor ST2825 Neuron-specific effects of interleukin-1β are mediated by a novel isoform of the IL-1 receptor accessory protein A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1 The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade Interleukin-1 family cytokines and mast cells: Activation and inhibition CAR-T cell therapy causes inflammation by IL-1 which activates inflammatory cytokine mast cells: Anti-inflammatory role of IL-37 Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-inflammatory strategies This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution The authors declare no conflict of interest. The IL-1β activity implicates binding between this cytokine and the IL-1R type I (IL-1RI), this binding triggers the interaction of Toll-IL-1-receptor (TIR) domains followed by MyD88 recruitment and downstream signalling cascades, which converge in the activation of several transcription factors and pro-inflammatory cytokine production [2, 6] . keywords: activation; anti; blood; cells; concentration; csf; cytokines; dependent; differentiation; dimerisation; diseases; effect; expression; factor; high; human; ifn; il-1ra; il-1β; il-6; inflammatory; inflammatory cytokines; inhibition; interleukin-1; levels; like; lps; mediators; molecule; myd88; pathway; pbmc; production; protein; receptor; recruitment; regulation; response; results; rhil-1β; role; secretion; signalling; significant; specific; st2825; stimulation; studies; study; table; tlr4; tnf; toll; transcription; vegf cache: cord-013366-sbdtpsz6.txt plain text: cord-013366-sbdtpsz6.txt item: #45 of 105 id: cord-013840-mi3uf4vk author: Zhang, Wei title: The metabolic regulator Lamtor5 suppresses inflammatory signaling via regulating mTOR-mediated TLR4 degradation date: 2019-08-29 words: 8578 flesch: 38 summary: A similar increase in Lamtor5 levels was observed in human monocytic THP-1 cells and peripheral blood mononuclear cells ( Fig. Strikingly, Lamtor5 expression was induced by LPS, Pam3CSK4, poly I:C, CpG (Supplementary Fig. keywords: acid; activation; activity; addition; amino; anti; antibodies; antibody; assay; association; autolysosomal; autophagosome; autophagy; balf; binding; bsa; cells; cellular; colocalization; complex; control; cytokine; data; degradation; deletion; dependent; deprivation; diet; dimer; domain; effect; endotoxic; engagement; essential; experiments; expression; factor; fig; fragments; function; gtpase; homeostasis; il-1β; il-6; immune; immunoblotting; induced; inflammation; inflammatory; inhibitor; innate; interaction; intracellular; key; kinase; knockdown; lamp1; lamtor5; lc3; leucine; levels; like; lps; lung; lysosomal; lysosome; macrophages; mechanism; metabolic; mice; model; molecular; molecules; mpo; mtorc1; nutrient; overexpression; p65; pathway; periods; phosphorylated; plasmids; process; processes; production; protein; raw264.7; reagent; receptor; regulator; response; role; sds; signaling; stimulation; structure; student; study; supplementary; test; tfeb; time; tir; tlr4; tnf; toll; total; zhang cache: cord-013840-mi3uf4vk.txt plain text: cord-013840-mi3uf4vk.txt item: #46 of 105 id: cord-014996-p6q0f37c author: None title: Posters_Monday_12 October 2009 date: 2009-08-06 words: 85276 flesch: 51 summary: ICU patients with acute respiratory failure requiring NIV were studied during three randomized consecutive 20 min-periods of NIV: ICU ventilator with and without NIV mode and NIV ventilator. EFL was recorded in 65% of ICU patients with pulmonary diseases: 65 % of ARDS patients, 75% of patients with respiratory infection, 75% of asthmatics and 85% of patients with COPD. keywords: abdominal; accuracy; accurate; activated; activation; activity; acute; addition; adequate; adherence; adjusted; administration; admission; admission patients; adult patients; adverse; age; agents; agreement; aim; aims; airway; aki; albumin; alveolar; analysis; anesthesia; animals; anova; antibiotic; anticoagulation; aortic; apache; apache ii; application; approach; appropriate; aptt; ards; ards patients; area; arf; arrest; arterial; artery; assay; assessment; associated; association; asynchrony; aud; available; average; background; bacteria; balance; baseline; basis; bed; best; better; bleeding; blood; blood pressure; bmi; body; brain; breathing; btt; bundles; bypass; calcium; calculated; cap; capillary; cardiac; cardiovascular; care; care patients; care unit; cases; catheter; cause; cells; center; central; centre; cerebral; challenge; changes; channel; characteristics; chest; chi; chronic; circuit; circulating; clinical; clotting; clp; cognitive; cohort; coma; combination; committee; common; community; comparison; complex; compliance; complications; concentration; conclusion; conditions; consciousness; consecutive patients; constant; continuous; contrast; control; control group; conventional; coronary; correlation; course; cpa patients; cpap; cpb; creatinine; criteria; critical; critical care; crp; crrt; cultures; current; curve; cvvh; cytokine; daily; data; database; day mortality; days; death; december; decision; decreased; degree; delirium; delivery; demographic; density; department; described; deterioration; developed; development; device; diagnosis; dialysis; differences; different; difficult; discharge; discrimination; discussion; disease; dose; drug; duration; dysfunction; dyspnea; eaa; early; ecmo; education; effects; effusion; efl; egdt; elderly patients; elevated; emergency; end; endothelial; endotoxin; episodes; epithelial; estimate; ethical; etp; evaluation; events; evidence; evlw; excess; experienced; experimental; expression; extubation; f4h5; factors; failure; female; ffp; fig; findings; fio; flow; fluid; following; fraction; france; free; frequency; frequent; functional; gas; gcs; gender; general; global; glucose; goal; good; graft; gram; greater; group; guidelines; half; hcap; head; healthy; heart; hemodynamic; heparin; hepatic; higher; higher mortality; hospital; hospital mortality; hospital stay; human; hypertension; iah; icp; icu; icu admission; icu length; icu mortality; icu patients; icu stay; icus; identification; ii score; iii; il-6; ill; illness; impact; implementation; important; improved; improvement; incidence; increase; independent; index; indications; induction; infection; inflammation; inflammatory; influence; information; infusion; inhalation; initial; injured; injury; injury patients; intensive; intensive care; interval; interventions; intracranial; introduction; intubated; invasive; iqr; isolated; itbv; itu; january; july; june; kidney; knowledge; known; laboratory; lack; lactate; large; lavage; lead; leading; left; length; levels; life; likely; limited; literature; liver; local; logistic; longer; los; lower; lps; lung; magnesium; main; major; majority; male; malignancy; management; mann; map; march; markers; material; mdcs; mean; mean age; measured; measurements; mechanical; mechanical ventilation; median; medical; medical icu; medical patients; membrane; metabolic; methods; mice; microbiological; microcirculation; mild; min; mitochondrial; mixed; mmhg; mmol; model; modified; monitoring; months; morbidity; morphine; mortality; mortality rate; mrsa; multiple; multivariate; muscle; myocardial; n =; national; nava; necessary; need; negative; neurological; new; nirs; non; norepinephrine; normal; nosocomial; number; nurses; nursing; obese patients; objectives; observational; observational study; occurrence; old; old patients; onset; operation; optimal; order; organ; origin; outcome; output; overall; oxygen; oxygenation; p =; pain; pancreatitis; pao; parameters; patients; pct; pdt; peak; peep; percentage; percutaneous; performance; perfusion; period; peripheral; permeability; phase; phosphate; physician; physiological; physiology; plasma; play; pleural; pmv; pneumonia; point; poor; population; position; positive; possible; post; postoperative; potential; ppv; practice; prbc; predictive; predictor; presence; present; pressure; prevalence; previous; primary; prior; probnp; procalcitonin; procedure; process; prognosis; prolonged; propofol; proportion; prospective; protein; protocol; psv; pts; pulmonary; pulse; quality; quantitative; randomized; randomly; range; rapid; rate; rats; ray; reason; recent; records; recovery; reduction; reference; referral; regression; related; relationship; relevant; reliable; removed; renal; replacement; report; research; respect; respiratory; respondents; response; results; resuscitation; retrospective; review; rhabdomyolysis; rifle; risk; role; rosc; routine; safe; saline; samples; saps; saturation; scale; score; scoring; scto; scvo; secondary; sedation; semi; sensitive; sensitivity; sepsis; sepsis group; septic patients; septic shock; serum; setting; severe; severe sepsis; severity; sex; sham; shock; shock patients; short; significant; significant differences; signs; similar; single; site; small; smartcare; sofa; software; sop; specific; specificity; spontaneous; spss; square; staff; standard; state; statistical; status; stay; step; strategies; students; studied; study; study period; subsequent; support; surgery; surgery patients; surgical; surgical icu; surgical patients; survey; survival; survivors; svv; syndrome; system; systemic; table; target; tbi; teaching; team; technique; term; tertiary; test; therapeutic; therapy; thoracic; tidal; time; tissue; tool; total; tracheostomy; transfusion; transplantation; trauma patients; traumatic; treatment; trial; triggering; type; understanding; underwent; unit; university; urban; urinary; urine; use; useful; utility; value; vap; variables; variation; vascular; vasopressors; venous; ventilation; ventilatory; ventricular; versus; vessels; volume; ward; weaning; week; weight; whitney; work; workshop; years cache: cord-014996-p6q0f37c.txt plain text: cord-014996-p6q0f37c.txt item: #47 of 105 id: cord-015021-pol2qm74 author: None title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162543 flesch: 45 summary: Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases. keywords: + +; 24h; 48h; abdominal; abdominal sepsis; ability; able; abnormalities; abscess; absence; absolute; account; accumulation; acid; acinar; activation; activities; activity; acts; acute; acute phase; addition; adequate; adherence; adherent; adhesion; administration; admission; adult; aeruginosa; affected; affinity; agents; aggressive; aim; albumin; alcohol; allogeneic; allograft; alpha; alterations; altered; alternative; alveolar; amino; amounts; analysis; anastomotic; anesthesia; anesthetized; animals; anova; antagonist; anti; antibiotics; antibodies; antibody; antigen; antiinflammatory; antimicrobial; antioxidants; antisense; antithrombin; aorta; aortic; apache; apoptosis; apparent; appearance; application; approach; appropriate; ards; ards patients; area; arf; arginine; arterial; arterial blood; artery; assay; assayed; assessment; associated; association; atp; attempt; attention; augmented; autologous; available; b cells; baboons; bacteremia; bacterial; bacterial sepsis; bactericidal; balance; balb; barrier; basal; baseline; basis; beginning; beneficial; benefit; best; beta; better; bfgf; bgc; binding; bioassay; biochemical; biological; bleeding; blind; blockade; blocking; blood; blood cells; blood flow; blood levels; blood loss; blood mononuclear; blood pressure; blood samples; blood transfusion; bmmc; body; bolus; bone; boston; bowel; bpi; bradykinin; bronchoalveolar; bum; burn; burn injury; burn patients; burned; burst; c mice; c3a; c3h; ca2; calcium; calculated; camp; cancer; cancer patients; candida; capable; capacity; capillary; cardiac; cardiovascular; care; cascade; cases; cathepsin; catheter; cause; cavity; cd14; cd16; cd18; cd3; cd4; cd8; cdlla; cea; cecal; ceil; cell activation; cell adhesion; cell death; cell injury; cell surface; cell types; cells; cellular; center; central; certain; cfu; chain; challenge; changes; characteristics; characterization; characterized; chemiluminescence; chemotactic; children; choice; cholesterol; chow; chronic; circulating; circulatory; cirrhosis; cirrhotic; class; classes; classification; clearance; clinical; clinical study; close; clotting; clp; cmi; cmv; cns; cntf; coagulation; coil; cold; coli; collagen; collected; colony; combination; combined; committee; common; communication; comparable; compare; comparison; complement; complete; complex; complexes; complicated; complications; components; composition; compounds; concentrations; concept; conclusion; concomitant; conditions; consecutive; consequence; considerable; constant; constitutively; consumption; contact; content; continuous; contraction; contrast; contributes; contribution; control; control animals; control cells; control group; control patients; conventional; coronary; correlate; correlation; corresponding; cortisol; count; course; coverage; cp-0127; criteria; critical; cross; crp; crp levels; crucial; csf; cultured; current; cutaneous; cvvh; cytokine levels; cytokine production; cytokine release; cytokine response; cytokines; cytokines tnf; cytometry; cytoplasmic; cytosolic; cytotoxic; cytotoxicity; daily; damage; data; dawley; days; days post; death; decreased; defect; defense; deficient; degradation; degranulation; degree; dehydrogenase; delayed; deleterious; delivery; density; department; dependent; deposition; depressed; dept; design; detectable; detection; determination; determined; development; dfo; diagnosis; diet; differences; different; differential; differentiation; difficult; diffuse; diminished; direct; discussion; disease; disorders; disruption; distal; distinct; distress; distribution; disturbances; dna; domain; donors; dose; double; drainage; drug; dth; duration; dxs; dysfunction; e-75; e.coli; e.g.; earlier; early; early sepsis; edema; effect; effective; effectiveness; efficacy; efforts; ehec; elastase; elderly; elderly patients; elective; elements; elevated; elevated levels; elevation; elimination; elisa; endocrine; endogenous; endothelial; endothelial cells; endotoxemia; endotoxin; endotoxin levels; endotoxin release; endotoxin shock; energy; enhanced; enhancement; enteral; entry; enzymes; epithelial; equivalent; erythrocytes; escherichia; essential; ester; et levels; etc; ethanol; evaluated; evaluation; events; evidence; evident; evoked; exact; example; excessive; exchange; excretion; exhibit; experimental; exposure; expression; extensive; extent; extraction; facs; factor; failure; fall; family; fashion; fast; fatal; fatty; features; fed; feeding; female; femoral; fever; fiber; fibrinogen; fibroblasts; field; filgrastim; final; findings; flora; flow; fluid; fluorescence; fmlp; focus; fold; following; follows; food; formation; forms; formula; fraction; fragments; free; frozen; function; future; gain; gamma; gap; gapdh; gastric; gastrointestinal; gel; gene; general; generalized; generation; genomic; germany; glucose; glutamine; glutathione; gms; good; graft; gram; gramnegative; granulocyte; greater; group; group b; group ii; group patients; growth; gsh; gtn; gut; gwt; h202; ha-1a; haemorrhage; half; hand; healing; healthy; heart; hej; help; helper; hemodynamic; hemoglobin; hemorrhagic; hemorrhagic shock; heparin; hepatectomy; hepatic; hepatitis; hepatocellular; hepatocytes; high; high dose; high levels; higher; highest; hind; hirudin; histamine; histological; hla; homeostasis; hormone; hospital; host; host response; hours; hrs; human; human blood; human sepsis; humoral; hydrogen; hypersensitivity; hypotension; hypothesis; hypoxia; i.e.; i.p; i.v; ibuprofen; icam-1; icu; identical; ifn; igg; igm; iii; il-1; il-1ra; il-2; il-3; il-4; il-6; il-6 levels; il-6 production; il-8; il6; ill patients; illness; imipenem; immediate; immune; immune cells; immune function; immune response; immune system; immunity; immunization; immunoglobulin; immunological; immunology; immunosuppression; impact; impaired; impairment; important; important role; improved; improvement; incidence; incision; increased; incubation; index; indicator; indirect; individuals; induced; inducible; induction; infected; infection; infiltration; inflammation; inflammatory; inflammatory cells; inflammatory cytokines; inflammatory mediators; inflammatory response; influence; influx; infusion; inhalation; inhibited; inhibitor; inhibits; initial; initiation; injured; injuries; injury; injury severity; inos; institute; insufficiency; intact; integrins; integrity; intensive; interactions; interferon; interleukin; interstitial; intervals; intervention; intestinal; intraabdominal; intracellular; intraperitoneal; intravascular; intravenous; introduction; invading; invasion; investigations; involved; involvement; ionomycin; ip3; irf; iron; irradiation; irreversible; ischemia; isolated; ivig; kallikrein; keto; key; kidney; killing; kinase; kinetics; kit; knee; knowledge; known; kupffer; l ~; laboratory; lack; lactate; lal; laparotomy; large; late sepsis; later; lavage; lbp; lead; leading; leakage; left; leh; length; lesser; lethal; lethality; leukocytes; levels; lewis; ligand; ligation; light; like; likely; limb; limited; limulus; lipid; lipopolysaccharide; liposomes; little; liver; liver blood; liver cell; liver failure; liver injury; local; localized; long; longer; loss; lower; lps; lps activation; lps administration; lps challenge; lps immune; lps injection; lps lethality; lps release; lps stimulation; lps treatment; lra; ltb4; lung; lung injury; lymphocytes; lymphoid; lymphokine; lysate; lysosomal; m.d; mab; macrophages; mad; magnitude; mainly; major; major surgery; malaria; male; malignant; management; manner; map; marked; markers; marrow; mass; massive; mast; mast cells; materials; matrix; maximal; maximum; mda; mean; measurements; mechanical; mechanisms; median; mediators; medical; medicine; medium; membrane; mesenteric; metabolic; metabolites; methods; mhc; mice; microcirculatory; microorganisms; microscopy; microvascular; mid; mif; migration; mild; minutes; mip; mitochondrial; mitogen; mixed; ml blood; ml lps; mln; mmhg; moab; mobilization; model; modified; mods; modulate; mof; molecular; molecules; monitoring; monoclonal; monocytes; monocytic; mononuclear; mononuclear cells; morbidity; mortality; mouse; mps; mrna; mucosal; multiple; multiple organ; multiple trauma; munich; murine; muscle; muscle cells; myeloid; myeloperoxidase; myocardial; n =; n t; n=10; n=12; n=5; n=6; n=7; n=8; nac; natural; nature; near; necessary; necrosis; necrosis factor; need; negative; negative sepsis; neopterin; nervous; network; neutralizing; neutropenia; neutrophils; new; ngf; nitric; nitrogen; nma; nmma; nmol; no2; nodes; non; normal; northern; nosocomial; novel; number; numerous; nutrition; oatmeal; objectives; observation; observed; occurrence; occurring; odn; oil; onset; open; operation; order; organ; organ dysfunction; organ failure; organ injury; organisms; origin; osf; outcome; output; overall; oxidase; oxidative; oxide; oxygen; oxygenation; p.g; p2 cells; p75; p<0.001; p<0.05; paf; pancreatic; pancreatitis; pap; parallel; parameters; parenteral; partial; particular; pathogenesis; pathogenic; pathological; pathophysiological; pathophysiology; pathways; patients; patients blood; patients levels; pattern; pbmc; pcr; peak; peptide; percentage; period; peripheral; peripheral blood; peritoneal; peritonitis; permeability; peroxidation; persistent; pge; pge2; phagocytic; phagocytic cells; phagocytosis; phase; phase response; phenomenon; phenotype; phosphate; phx; physiologic; pigs; pituitary; pivotal; pkc; pla2; placebo; placebo group; placebo patients; plasma; plasma concentrations; plasma endotoxin; plasma levels; plasma samples; plasma tnf; platelet; play; plf; pma; pmn; pmnl; pmns; pmol; pneumonia; po2; pof; points; polymorphonuclear; polypeptide; polytrauma; pool; poor; population; portal; positive; possibility; possible; post; post lps; postischemic; postoperative; posttraumatic; potential; powerful; ppm; precise; preclinical; precursor; preliminary; preoperative; preparation; presence; present; present study; presentation; pressure; pretreated; pretreatment; prevention; previous; primary; priming; prior; probes; problems; procedure; process; processes; produced; production; products; profound; progenitor; prognosis; proliferate; proliferation; prolonged; promising; promoter; pronounced; properties; prophylactic; prophylaxis; proportion; prospectively; prostacyclin; prostaglandin; protease; protective; protein; proteinases; proteolytic; protocol; pseudomonas; pts; ptx; pulmonary; puncture; purified; purpose; quantitative; question; rabbits; radicals; rain; randomized; range; ranitidine; rapid; rate; rats; rbpi23; reaction; reactive; recent; receptor; recipients; recombinant; recovery; recruitment; reduced; regard; region; regional; regression; regulation; regulatory; related; relationship; relative; relaxation; release; releasing; relevance; relevant; remote; renal; repair; reperfused; reperfusion; reperfusion injury; replacement; reported; reports; research; resection; resistance; respect; respiratory; response; response results; response syndrome; responsible; responsiveness; results; resuscitation; review; rhg; ringer; rings; rise; risk; role; routine; s.c; safety; saline; salmonella; samples; sampling; sbi; scald; school; score; scoring; second; secondary; secrete; secretion; sections; selected; selectin; sem; sensitive; sensitivity; separate; sepsis; sepsis induction; sepsis model; sepsis score; sepsis study; sepsis syndrome; septic animals; septic complications; septic group; septic organ; septic patients; septic response; septic shock; septicemia; sequelae; sequences; sequential; sequestration; sera; serial; series; serine; serum; serum il-6; serum levels; serum tnf; setting; severe; severe sepsis; severe trauma; severity; sex; sham; shed; shed blood; shedding; shock; shock group; short; shunt; sicu; signal; significant; significant increase; signs; similar; simple; simultaneous; single; sirs; site; situ; situation; size; skeletal; skin; slices; sll-6r; small; smooth; sod; sodium; soluble; soluble tnf; solution; source; space; special; species; specific; specificity; spleen; spleen cells; splenic; sprague; stable; stages; staining; standard; start; state; statistical; status; stay; step; stimulated; stimulation; stimuli; stimulus; stnfr; strains; strategies; strategy; stress; strong; structure; studies; study; study period; study results; subjects; subsequent; subsets; substances; substantial; substrates; successful; suffering; sufficient; summary; superior; supernatants; superoxide; supplemented; supply; support; suppression; surface; surgery; surgical; surgical patients; surgical trauma; survival; surviving; survivors; susceptibility; symptoms; syndrome; synergistic; synthase; synthesis; synthetic; system; systemic; systemic inflammatory; t cells; target; taurine; tbsa; techniques; temperature; temporary; tendency; terminal; terms; test; tested; testing; tgf; tgf-131; therapeutic; therapies; therapy; thermal; thermal injury; thickness; thl; thoracic; thrombin; thromboxane; thymic; thymus; time; tissue; tissue injury; tn3; tnf; tnf activity; tnf levels; tnf mab; tnf mrna; tnf production; tnf receptors; tnf release; tnf treatment; tnfa; tnfc~; tool; total; toxic; toxicity; toxins; tpn; tract; transcription; transduction; transferrin; transfusion; transient; transit; translocation; transmembrane; transplantation; transplanted; transport; trauma patients; trauma sepsis; traumatic; treated; treatment; treatment group; trials; trigger; tumor; type; ulcers; unchanged; unclear; underlying; understanding; underwent; units; university; unknown; untreated; uptake; urinary; usa; use; useful; valuable; values; variables; variety; vascular; vasoconstriction; vehicle; vein; venous; venous blood; ventilated; ventilation; venules; verapamil; versus; vessels; viable; viral; vitro; vivo; volume; volunteers; wall; wbc; weeks; weight; white; white blood; wide; wilcoxon; wistar; work; wound; xanthine; years; zymosan cache: cord-015021-pol2qm74.txt plain text: cord-015021-pol2qm74.txt item: #48 of 105 id: cord-015082-l629n8is author: None title: Poster Sessions 323-461 date: 2002-08-29 words: 26609 flesch: 50 summary: Isoflurane sedation of ICU patients has previously been shown to be useful but has not come into wide clinical use for a number of reasons. Isoflurane administered via the ACD for sedation of ICU patients is environmentally safe, requires small volumes of isoflurane and may provide better quality of sedation than midazolam. keywords: 123i; abdominal; abnormalities; acr; activation; activity; acute; administration; admission; age; aim; albicans; albumin; analysis; animals; antithrombin; apache; arf; arterial; artery; asp; associated; association; average; bacteremia; bacterial; baseline; better; blood; brain; bypass; candida; cardiac; care; cases; catheter; cause; cell; central; cerebral; changes; children; clinical; common; complications; concentrations; conclusion; consecutive; continuous; control; control group; coronary; correlation; course; cpb; criteria; crp; csa; culture; cytokines; damage; data; days; death; decrease; development; diagnosis; differences; different; disease; dose; duration; dysfunction; early; ecg; effect; elevated; emergency; endothelial; endotoxemia; endotoxin; enos; epcr; evaluation; exact; factor; failure; female; fisher; flagellin; flow; fluid; fold; following; frequencies; frequency; function; general; gly; gram; group; head; health; heart; higher; hospital; hours; hypothermia; icu; icu patients; il-1ra; il-6; il-8; illness; important; improvement; incidence; increase; independent; index; infection; inflammatory; influence; infusion; inhibitor; injury; inos; intensive; introduction; intubation; ischemia; isoflurane; isolated; january; left; length; leukocyte; levels; local; loss; lower; lps; lung; lymph; major; male; map; mca; mean; measurement; mechanical; median; medical; mesenteric; methods; mif; min; minocycline; model; moderate; mods; months; morbidity; mortality; mosf; myocardial; necrosis; need; negative; new; non; norepinephrine; normal; nppv; number; observational; oesophagus; onset; organ; outcome; output; oxygen; oxygenation; p<0.05; pain; patients; pediatric; perfusion; period; permeability; phase; plasma; points; polymorphisms; population; positive; postoperative; preoperative; presence; present; pressure; procedures; prognostic; prospective; protein; protein c; pto2; pts; pulmonary; range; rate; rats; receptor; reduction; related; release; renal; respiratory; response; results; rifampin; right; risk; role; s-100; sah; saline; samples; score; sedation; sepsis; septic; serum; severe; severity; shock; significant; signs; similar; sofa; spp; statistical; stay; stress; stroke; studies; study; substitution; support; surgery; surgical; survival; survivors; syndrome; systemic; table; test; therapeutic; therapy; time; tissue; tnf; tni; total; tpa; tract; transfusion; trauma; traumatic; treatment; troponin; tumor; type; unit; values; variables; vascular; ventilation; ventricular; vitro; volume; water; wave; women; years cache: cord-015082-l629n8is.txt plain text: cord-015082-l629n8is.txt item: #49 of 105 id: cord-015147-h0o0yqv8 author: None title: Oral Communications and Posters date: 2014-09-12 words: 73903 flesch: 39 summary: After 3 months of exposures, inflammatory cells in bronchoalveolar lavage fluid were increased in both the HCR-and LCR-smokeexposed(SE) animals compared to air-exposed controls (p<0.001); however there was a 2-3-fold increase in the number of neutrophils and lymphocytes in the LCR-over the HCR-SE group (p<0.001).Histopathology revealed there was greater inflammation and lung damage present in the LCR-versus HCR-SE group (p<0.05). This causes the symptoms of the early phase of AI and the onset of the late phase characterized by the penetration in the inflamed tissue of inflammatory cells, notably the eosinophils. keywords: a2ar; ability; able; absence; accumulation; achr; acid; action; activated; activation; active; activities; activity; acute; adaptive; addition; adherence; adhesion; administration; adult; adv; aeruginosa; affected; affinity; agents; aggregation; aia; aim; airway; allele; allergic; allodynia; alpha; alterations; altered; amounts; analysis; angiogenesis; animals; antagonist; anti; antibodies; antibody; antigen; antiinflammatory; ap-1; apc; apoptosis; apoptotic; approach; arachidonic; arry-162; arterial; arthritis; assay; associated; association; asthma; astrocytes; atherosclerosis; atopic; atp; australia; autoimmune; b cells; background; bacterial; bal; balb; barrier; basal; basophils; beneficial; beta; better; binding; bioactivity; biological; biology; biopsies; biotin; blister; blockade; blocking; blood; blot; bone; bovine; bowel; bpw; brain; brazil; c mice; c57bl/6; c5ar; ca2; cadpr; calcitriol; calcium; canada; cancer; capable; capacity; carrageenan; cartilage; cascade; cases; caspase-1; cause; cbp; ccp; cd4; cell activation; cells; cellular; center; central; centre; cerebral; certain; chain; challenge; changes; characterized; chemokine; chemotaxis; chromosome; chronic; chronic inflammatory; cii; circulation; class; clinical; clp; cns; coagulation; colitis; collagen; colon; combination; common; complement; complete; complex; components; compounds; concentration; conclusions; conditions; considered; constitutively; contact; contrast; control; cord; correlated; correlation; corresponding; course; cox-2; cpla2; critical; crohns; crp; csf; cultured; current; cutaneous; cx5; cyclin; cyclooxygenase; cytokines; cytoskeleton; daily; damage; data; day; days; dcs; decrease; defense; deficient; deficient mice; degradation; delayed; demonstrate; dendritic; dendritic cells; denmark; density; department; dependent; depletion; dermatitis; destruction; detrusor; development; dexamethasone; diabetes; diabetic; diagnostic; diet; differences; different; differential; differentiation; discovery; disease; disorders; distinct; dna; dogs; domain; dose; dpt; drug; dss; dynamic; dysfunction; e.g.; eae; early; ebi3; effect; effective; effector; efficacy; egfr; elevated; elisa; endogenous; endothelial; endothelial cells; enhanced; enzymatic; enzyme; eosinophils; epcr; epidermal; epidermis; epithelial; erk; erk1/2; essential; established; events; evidence; examination; example; experimental; exposure; expression; expression levels; extracellular; extracts; factor; family; fat; fcs; female; fibroblasts; fibrosis; findings; flavonoids; flow; fluid; fluorescence; focus; fold; formation; fprl1; free; function; gamma; gata-3; gene; generation; genetic; genome; germany; gimap5; glucocorticoids; glycine; group; growth; h2s; h4r; hand; hdsmc; healthy; heme; high; higher; highest; hind; histamine; histological; hit; hla; hospital; host; hours; human; hydrogen; hyperalgesia; hyperplasia; hypothesis; i.p; ibd; ic50; icam-1; ifn; ifna; ifnbeta; ikba; ikka; il-1b; il-1beta; il-23; il-4; il-6; il-8; immune; immune response; immunity; immunization; immunohistochemistry; immunomodulatory; impaired; important; important role; incidence; increased; incubation; individual; induced; inducible; induction; infected; infiltration; inflamed; inflammation; inflammatory; inflammatory activity; inflammatory arthritis; inflammatory bowel; inflammatory cells; inflammatory conditions; inflammatory cytokines; inflammatory diseases; inflammatory effects; inflammatory mediators; inflammatory response; inflammatory skin; influence; inhibited; inhibition; inhibitors; initial; injection; injury; innate; inos; institute; insulin; integrin; interaction; intestinal; intravital; introduction; investigated; involvement; ischemic; isolated; italy; japan; jnk; joint; joint inflammation; keratinocytes; key; kidney; kinase; knee; knockout; known; large; lavage; ldl; leading; leo; lesions; leukocyte; levels; ligand; like; likely; lilra2; limited; line; lipid; lipopolysaccharide; little; liver; local; loss; low; lower; lps; ltb4; lung; lung inflammation; lymphocytes; mab; macrophages; major; male; manner; mapk; marked; markers; marrow; mast; mast cells; matrix; mbp; mean; measured; measurement; mechanical; mechanisms; mediate; mediators; medical; medicine; medium; members; membrane; memory; mesenteric; metabolism; methods; mice; microscopy; mif; migration; mitogen; mmp-9; model; molecular; molecules; monoclonal; monocytes; mononuclear; mouse; mrna; mrna expression; mrna levels; multiple; murine; muscle; mutation; myeloperoxidase; nabs; nad+; natural; ncf1; necrosis; negative; netherlands; neurons; neutralizing; neutrophils; new; nfkb; ngf; nitric; nkg2d; nod1; non; normal; novel; nuclear; nucleus; number; objectives; observed; oedema; onset; oral; order; organ; osteoarthritis; outcome; ova; overexpression; oxidative; oxide; oxygen; p.o; p13; p38; p65; p<0.05; paf; pain; pancreatic; pancreatitis; par-2; par1; par2; par4; parameters; pars; particular; pathogenesis; pathogenic; pathological; pathways; patients; pattern; paulo; paw; pbmc; pcr; peptide; percentage; period; peripheral; peritoneal; permeability; pge2; phagocytosis; pharmacological; phase; phenotype; phosphorylation; physiological; pi3k; pivotal; pkc; plasma; plasma cells; platelet; pma; pmn; pollutants; population; positive; possibility; possible; posters; potential; pouch; prepared; presence; present; present study; presentation; pretreatment; prevention; primary; process; processes; production; products; profile; progression; proliferation; promoter; properties; prostaglandin; proteases; protective; protein; protein expression; psoriasis; psoriatic; pulmonary; purpose; range; rapid; rats; reaction; reactive; recent; receptor; recombinant; recovery; recruitment; reduced; region; regulated; regulation; regulatory; related; relationship; relative; release; relevant; remodeling; renal; reperfusion; research; resistance; response; responsible; results; reversed; rheumatoid; rheumatoid arthritis; risk; rock-2; role; route; s100a12; saa; safety; saline; samples; school; score; secondary; secretion; selectin; selective; sensory; sepsis; sequence; sera; serine; serum; severe; severity; shock; shows; signaling; significant; signs; similar; single; sirna; site; skin; sle; slx-2119; small; snp; socs1; soluble; species; specific; specificity; specimens; spla; spleen; staining; starting; stat1; step; stimulated; stimulation; strains; stress; stroke; strong; structural; studies; study; subsequent; superoxide; supplement; support; suppression; surface; survival; susceptibility; swelling; symptoms; syndrome; synovial; synthase; synthesis; synthetic; system; systemic; sâ¼o; t cells; target; targeting; tdzd-8; technique; tested; th1; th17; th2; therapeutic; therapy; thickness; thp-1; thrombin; time; tissue; tlr2; tnbs; tnf; tnfa; tnfalpha; tolerance; topical; total; tpa; tpko; trafficking; transcription; transduction; transgenic; transient; treated; treatment; trpv1; trypsin; ttp; tumor; tumor cells; type; type mice; underlying; understanding; unique; university; unknown; untreated; uptake; usa; useful; variety; vascular; vegf; vehicle; vein; vitro; vivo; volunteers; wall; water; weeks; weight; western; wide; wild; wistar; work; years; zymosan cache: cord-015147-h0o0yqv8.txt plain text: cord-015147-h0o0yqv8.txt item: #50 of 105 id: cord-015394-uj7fe5y6 author: None title: Scientific Abstracts date: 2008-12-23 words: 242809 flesch: 48 summary: The highest level of -tubulin acetylation (2.5-fold) was observed with Vinblastine at 10-fold IC 50 after 48 h. Exposure to Microtubule interacting agents and TSA resulted in increased cell surface expression of Ep-CAM in a time and dose dependent manner. Finally, we elucidated a link between the RA and TGF-pathways by assessing the impact of RA treatment of TGF-3 expression, demonstrating that TGF-3 template decreased to levels comparable to myometrial cell expression (0.84±0.12 fold). keywords: -tubulin; 1,2; 11b; 12h; 18s; 24h; 48h; abc; abdominal; aberrant; ability; abnormal; abnormalities; abortion; abruption; absence; absent; abundance; abundant; account; accumulation; accuracy; acetate; acetylation; acid; acidemia; acidosis; acth; actin; activation; active; activin; activities; activity; acts; acute; adaptive; addition; adenomyosis; adenosine; adequate; adhesion; adiponectin; adjacent; adjusted; adjustment; adma; administration; admission; adrenal; adult; adulthood; advanced; adverse; aea; aea levels; afc; affected; affects; affymetrix; age; aged; agents; aim; aims; akt; alcohol; alk1; allele; alpha; alterations; altered; alternative; amh; amino; amniocentesis; amnion; amniotic; amounts; amplification; analysis; anandamide; androgen; androstenedione; anesthesia; aneuploidy; angeles; angii; angiogenesis; angiogenic; angiotensin; animals; anomalies; anova; antagonist; antenatal; anti; antibiotics; antibodies; antibody; antigen; antihypertensive; antioxidant; aorta; apgar; apoptosis; apoptotic; apparent; application; applied; approach; appropriate; approval; aqp1; arbitrary; areas; arginine; aromatase; aromatase expression; array; arrest; arterial; arteries; artery; assay; assayed; assess; assessment; assisted; associated; association; atgl; atp; attached; attenuated; australia; available; average; avp; axis; b cells; b levels; babies; background; bacterial; balance; balloon; band; basal; baseline; bax; benign; best; beta; betamethasone; better; bewo; bewo cells; big; bilateral; bile; binding; biochemical; biological; biology; biomarkers; biopsies; biopsy; biosynthesis; birth; birthweight; blastocysts; bleeding; blinded; block; blocking; blood; blood cells; blood flow; blood pressure; blood samples; blot; blot analysis; blotting; bmi; bnp; body; bouin; bpa; brain; branch; breast; breastfeeding; buffer; bypass; c fetal; cadherin; calcium; calculated; california; camp; cancer; cancer cells; candidate; capacity; carboplatin; carcinoma; cardiac; cardiovascular; care; carriers; cascade; cases; caspase; caspase-3; catheters; caucasian; cause; caveolae; cb1; cbf; cd25; cd3; cd4; cd44; cd45; cd55; cd8; cdb; cdna; cell culture; cell cycle; cell death; cell function; cell growth; cell line; cell proliferation; cell protein; cell types; cells; cellular; center; centile; central; centre; cerebral; cervical; cervical cells; cervix; cesarean; cfos; cgrp; chain; changes; channels; characteristics; characterized; chd; chemokine; chemotherapy; chi; chicago; child; cholesterol; chorioamnionitis; choriocarcinoma; chorion; chorionic; chromatin; chromosome; chronic; chymotrypsin; cigarette; cincinnati; circulating; circumference; cisplatin; class; cleavage; clinical; clip-170; clomiphene; clp; coagulation; cohort; cohort study; collagen; collection; college; colon; colonic; combination; combined; common; communication; comparable; comparison; complete; complex; compliance; complicated; complications; components; composition; comt; concentrations; conception; conclusions; conditions; confidence; confluent; confocal; congenital; conjugated; consecutive; consistent; constant; content; continued; continuous; contractile; contractility; contractions; contrast; contribute; control; control cells; control group; control pregnant; control study; control women; cord; corin; correlated; correlation; corresponding; cortex; cortical; cortisol; counseling; couples; course; cox-2; cpb; cpeb; cranberry; crf; crf expression; crh; criteria; critical; cross; crp; crucial; csf; ctr; culture; cultured human; cumulative; cumulus cells; current; curve; cvs; cycle; cyclin; cyp17; cytokine expression; cytokines; cytometry; cytoplasmic; cytotrophoblast; daily; dallas; damage; dams; data; database; date; david; dawley; day; days; dcs; death; decidual cells; decidualization; decline; decrease; defects; deficiency; degradation; degree; dehydrogenase; delay; deletion; deliveries; delivery; demise; demographic; demonstrated; density; department; dependent; dept; design; detectable; detection; determination; detroit; development; device; dga; dha; diabetes; diabetic; diagnosis; diameter; diastolic; diet; dietary; differences; different; differential expression; differentiation; dilatation; diminished; direct; discussion; disease; disorders; distal; distention; distinct; distress; distribution; division; dna; domain; donor; doppler; dose; double; downregulation; downstream; drug; dscs; duration; dysfunction; dysregulation; earlier; early; early pregnancy; ebp; ecm; ecog; ecs; ectopic; education; effect; effective; efficacy; egfr; eif2; elastin; elective; elements; elevated; elevation; elisa; embryo; embryonic; emg; endocannabinoid; endocrine; endocrinology; endogenous; endometrial; endometrial cells; endometrial expression; endometriosis; endothelial cells; endothelium; enhanced; enos; environment; enzyme; eoc cells; epab; epcs; epigenetic; epithelial; erk; erk1/2; erk2/1; essential; established; estradiol; estrogen; estrus; et-1; etb; ethnicity; etiology; evaluation; events; evidence; evident; evt; ewes; exact; exam; examination; excess; excretion; exerts; exhibit; exon; experience; experiments; explants; exponent; exposed; exposure; expression; expression analysis; expression changes; expression data; expression levels; extent; extracellular; extraction; extracts; extravillous; ezh2; f4/80; faah; factor; failed; failure; fak; fallopian; false; family; fashion; fasting; fat; fatty; fbs; features; fed; feeding; female; femoral; fertilization; fertilized; fetal; fetal arterial; fetal blood; fetal body; fetal brain; fetal cells; fetal circulation; fetal death; fetal development; fetal dna; fetal effects; fetal growth; fetal heart; fetal inflammatory; fetal levels; fetal liver; fetal lung; fetal membranes; fetal placental; fetal plasma; fetal sheep; fetal weight; feto; fetuses; fgr; fhr; fibers; fibroblasts; fibroids; figure; findings; fixed; flow; fluid; fluorescence; folate; fold; fold increase; folic; follicles; follicular; following; food; force; formation; forskolin; foxp3; fraction; fragments; free; frequencies; frequency; frozen; fsh; fshr; function; future; gaba; gain; galveston; gapdh; gbs; gcm1; gdm; gdm women; gel; gender; gene; general; generated; generation; genetic; genome; genomic; genotype; genotyping; gestation; gestational age; gfr; ghrelin; glandular; global; glomerular; glucocorticoids; glucose; gnrh; goal; gonadotropin; good; gradient; grams; grant; granulosa cells; greater; groningen; group; group c; growth; growth factor; guinea; gynecology; half; hand; harbor; has2; haven; hbegf; hcg; hcg levels; hcy; hdl; health; heart; hela cells; help; hemorrhage; heparanase; hepatic; hfix; hgf; higher; higher expression; higher levels; highest; hispanic; histologic; histone; history; hla; homeostasis; homocysteine; hormonal; hormone; horn; hospital; hours; hoxa10; hoxa10 expression; hpa; hplc; hpx; hrs; hscrp; hsd1; hsd1 expression; hsd2; htert; hud; human; human cells; human endometrial; human fetal; human labor; human myometrium; human ovarian; human placental; human pregnancy; human trophoblast; human uterine; hur; huvec; hypertension; hypothalamic; hypothesis; hypothesized; hypoxia; hysterectomy; iai; icsi; identification; ifn; igf; igf-1; ihc; iii; ikk; ikk expression; il-1; il-6; il-6 levels; il-8; il-8 expression; il1; image; imaging; imd; immature; immediate; immortalized; immune; immune cells; immunity; immunoblotting; immunohistochemistry; immunoreactivity; immunostained; immunostaining; impact; impaired; imperial; implantation; important; improved; improvement; incidence; incontinence; increased; incubation; index; indices; individual; induced; induction; infants; infection; infertility; inflammation; inflammatory; inflammatory cells; inflammatory response; influence; informed; infusion; inhibin; inhibited; inhibitor; inhibits; initial; initiation; injury; innate; inos; institute; insufficiency; insulin; insulin levels; intact; integrin; intensities; intensity; interactions; intercourse; interest; interface; internal; intervals; intervention; intrauterine; intravenous; introduction; invading cells; invasion; invasive; investigation; involved; involvement; iqr; ishikawa; ishikawa cells; isoforms; isolated; isometric; israel; italy; iufd; iugr; ivf; japan; jar; jnk; john; jun; kda; key; kidney; kinase; kingdom; kit; knock; known; labeling; labor; laboratory; labouring; labyrinth cells; lack; lactate; lactation; laparoscopic; large; late pregnancy; latency; later; layers; leading; left; leiden; leiomyoma; length; leptin; lesions; leukocytes; levels; levosimendan; lgr7; libitum; ligand; likelihood; likely; limited; linear; lines; lipid; lipopolysaccharide; liquid; litter; little; lmp; load; local; localization; logistic; london; long; loss; louisville; low levels; lower; lowest; lox; lpa; lps; luciferase; lung; luteal; luteal cells; lyapunov; lymphocytes; macrophages; macrosomia; main; maintenance; major; majority; maldi; male; malignant; management; manner; mapk; marked; markers; mass; mast cells; materials; maternal; maternal age; maternal blood; maternal fetal; maternal growth; maternal plasma; maternal serum; maternal weight; matrigel; matrix; matter; maturation; maximal; maximum; mbs; mca; mcp; mean; mean±sem; measure; measurements; mechanical; mechanisms; meconium; media; mediate; mediators; medical; medicine; medium; medroxyprogesterone; members; membranes; menopause; menses; menstrual; menstruation; mesenchymal cells; mesenteric; metabolic; metabolites; metalloproteinases; methods; methylation; mfr; mg protein; mice; michael; microarray; microscopy; microvascular; mid; migraine; migration; mii; mild; milieu; min; minimal; minutes; mis levels; miscarriage; mitf; mitochondrial; miu; mmhg; mmp-9; mmp2; mmr; mnr; model; moderate; modification; modified; molecular; molecules; monitoring; monoclonal; monocyte; mononuclear cells; months; morbidity; morphology; mortality; mothers; motility; mouse; mrna expression; mrna levels; mrnas; mtor; mtt; multiple; murine; muscle cells; mutation; myd88; myocytes; myoferlin; myogenic; myometrial; myostatin; n=10; n=11; n=12; n=15; n=20; n=3; n=5; n=6; n=7; n=8; n=9; national; natural; near; necessary; necrosis; need; negative; neonatal; neonates; nephron; nerve; netherlands; neural; neuronal; neurons; neutrophils; new; newborn; newcastle; nfkappab; nicu; nih; nitric; nk cells; nkg2d; nmol; non; nonpregnant; normal; normal fetal; normal human; normal placental; normal pregnancy; normal term; normalized; normotensive; normoxic; novel; nrbcs; nuclear; nuclei; nucleotide; nulliparous; number; nutrient; nutrition; obese; obese women; obesity; objective; observations; observed; obstetrics; occlusion; odds; offspring; ohpc; ohss; ongoing; onset; oocytes; operative; optimal; oral; order; organ; origin; otr; outcome; output; ovarian; ovarian cells; ovariectomized; ovaries; ovary; overall; overexpression; overweight; ovine; ovine fetal; ovulatory; oxidase; oxidative; oxide; oxygen; oxytocin; p =; p levels; p38; p53; p65; p70; p<.001; p<0.001; p<0.05; paclitaxel; pain; palsy; paraffin; parallel; parameters; parity; partal; particular; parturition; passage; passive; pathogenesis; pathological; pathology; pathophysiology; pathway; patients; pattern; pbef; pcao; pcn; pcos; pcos women; pcr; peak; pelvic; peptide; percentage; perfusion; periconceptional; perinatal; period; peripheral; peritoneal; permeability; peroxide; peroxide levels; persistent; pet; pgdh; pge; pgf; pgf2; pghs-2; pgrmc-1; phase; phenotype; phosphorylation; physiological; pi3k; pituitary; pkc; placebo; placement; placental; placental cells; placental expression; placental growth; placental protein; placental samples; placental tissue; placentation; plasma; plasma levels; plasmid; platelet; plates; play; plgf; pof; point; poly(i; polyclonal; polycystic; polymorphisms; poor; population; positive; positive cells; possibility; possible; post; postmenopausal; postmenopausal women; postnatal; postpartum; potassium; potential; ppar; pprom; practice; precursor; predictive; predictors; predominant; preeclampsia; preeclamptic women; pregnancies; pregnancy; pregnancy outcome; pregnancy rate; pregnancy results; pregnancy study; pregnant levels; pregnant mice; pregnant rats; pregnant women; preliminary; preliminary results; premature; premenopausal; prenatal; prepared; presence; present; present study; pressure; preterm; preterm birth; preterm delivery; preterm labor; pretreated; pretreatment; prevalence; prevention; previous; primary; primary human; primers; prior; probes; procedure; process; processes; processing; production; products; profile; progenitor cells; progesterone; progestins; programmed; programming; prolapse; proliferation; prolonged; promoter; properties; proportion; prorenin; prospective; prostaglandin; protease; protein expression; protein levels; proteins; protocol; providers; psychological; ptb; ptgfr; pthrp; ptl; pulmonary; pups; purified; purpose; putative; qpcr; qrt; quality; quantification; quantitative; quiescence; r5020; rabbit; racial; randomized; range; rank; rapid; rare; ratios; rats; reaction; reactive; real; recent; receptivity; receptor; receptor expression; receptor mrna; recombinant; records; recruitment; recurrent; reduced; reference; region; regression; regular; regulated; regulation; regulatory; related; relationship; relative; relative expression; relaxation; relaxin; release; releasing; relevant; remodeling; removal; renin; repair; repeated; reported; reports; reproductive; research; reserve; resistance; resistin; respect; responders; response; responsible; responsiveness; restricted; restriction; results; retinol; retrieval; retrieved; retrospective; retroviral; reverse; review; rhoa; rhrlx; right; ringo; ripening; rise; risk; robust; role; rotterdam; routine; ru486; rupture; s1p; saa; saline; samples; sampling; san; scale; school; sciences; score; screening; second; secondary; secretion; secretory; sections; segment; selectin; sem; semi; seng; sensitive; sensitivity; separate; separation; sequence; serial; series; serum; serum levels; setting; severe; severity; sex; sflt-1; sflt1; sga; shear; sheep; short; shorter; shows; shreveport; sicam-1; signaling; signals; significant; significant differences; significant increase; similar; single; singleton; sirna; site; sk3; skin; slpi; small; smaller; smoke; smokers; smoking; smooth; smurf2; snap; sno; snp; snps; sodium; software; soluble; solution; somatic; sonographic; source; species; specific; specificity; specimens; spindle; spleen; splicing; spontaneous; sprague; sptb; spy; square; stage; staining; standard; standardized; star; stat3; statistical; statistical analysis; status; stem cells; step; stephen; steroid; stimulation; stimuli; stra6; strategy; stress; stretch; strips; stromal cells; strong; structure; student; studies; study; study design; study group; subjects; subsequent; substantial; substrate; subunit; successful; sum; supernatants; supplementation; supplemented; support; suppressed; suppression; surface; surgery; surgical; survival; sympathetic; symptoms; syncytial; syncytiotrophoblast; syndrome; synergistic; synthase; synthesis; synthetic; system; systemic; systolic; t cells; table; target; taylor; technique; technology; teenagers; temperature; temporal; term; term fetal; term placental; term pregnant; terminal; test; tested; testing; testosterone; texas; tgf; therapeutic; therapies; therapy; thickness; thrombin; thy-1; time; time pcr; timing; tissue; tlr-3; tlr2; tlr4; tnf; tnfa; tnl; toco; tocolytic; tof; tolerance; toll; torrance; total; total protein; traditional; trail; transcribed; transcription; transcripts; transfection; transfer; transient; translation; transport; treatment; treg cells; trend; trials; trimester; trophoblast cells; trophoblasts; true; tsa; tubal; tube; tumor; tunel; turn; twin; type; tyrosine; ucla; ucn2; udp; ultr cells; ultrasound; umbilical; unchanged; unclear; underlying; understanding; understood; underwent; unique; united; units; university; university medical; unknown; untreated; upa; upbf; upper; upstream; uptake; uric; urinary; urocortin; usa; useful; uterine; uterine blood; utero; uteroplacental; uterus; vaginal; values; variables; variance; variant; variation; variety; vascular; vasculature; vasodilation; vasodilatory; vector; vegf; vegf expression; vegfr-2; vehicle; vein; velocity; venous; vesicles; vessels; viability; viable; villi; villous; viral; virgin; vitamin; vitro; vivo; volume; vwf; wall; wang; weeks; weeks gestation; weight; western; white; whitney; wide; wild; withdrawal; wks; women; work; yale; years; york; young; younger cache: cord-015394-uj7fe5y6.txt plain text: cord-015394-uj7fe5y6.txt item: #51 of 105 id: cord-018969-0zrnfaad author: Giese, Matthias title: Types of Recombinant Vaccines date: 2015-09-24 words: 14241 flesch: 44 summary: Vaccine proteins made by the host are natural proteins and contain important posttranslational modifi cations such as the correct glycosylation. By covalent linkage of PRP with T cell dependent protein antigens, a conjugated vaccine was created to overcome the T cell independent characteristics of PRP. keywords: ability; able; acaricide; acid; activation; adjuvant; administration; adult; amino; animal; antibodies; antibody; antigen; antigenic; apis; associated; attenuated; available; bacteria; bees; binding; blood; bm86; cacy; candidate; capsid; carrier; cation; cattle; ccd; cells; cellular; challenge; chemical; class; clinical; coli; colony; common; complete; complex; conserved; contact; control; core; cross; days; dcs; delivery; destructor; development; different; disease; dna; dna vaccine; dogs; effective; effects; effi; egfp; epitopes; essential; exneri; expression; feeding; fi sh; fig; food; gas; gas vaccine; gene; genome; group; gut; heart; heterologous; high; honey; horses; host; human; humoral; identifi; iga; igg; immune; immune response; immunity; immunization; immunogenicity; impact; important; induced; induction; infected; infection; infl; insect; intranasal; invaplex; ipab; kda; lab; lack; lactobacillus; levels; like; likely; lipid; m protein; main; major; meal; melanoma; mellifera; membrane; mice; microplus; mites; model; molecules; mortality; mucosal; multiple; natural; need; new; non; norovirus; norwalk; nov; novs; number; nvcp; opsonic; oral; outer; particles; pathogen; peptide; period; pestis; plague; plasmid; plasmid dna; populations; positive; present; process; production; protective; protein; prp; purifi; reactive; recombinant; region; resistance; response; results; rhipicephalus; rna; role; rst; safety; salmon; secretion; sequence; serum; shigella; shigella fl; signal; single; site; sonnei; species; specifi; spread; strains; streptococcal; studies; subunit; surface; symptoms; system; systemic; target; tick; tick vaccine; tissue; toxin; transmission; type; united; vaccination; vaccine; varroa; vectors; viral; virus; viruses; vlps; vp1; wild; wnv cache: cord-018969-0zrnfaad.txt plain text: cord-018969-0zrnfaad.txt item: #52 of 105 id: cord-022136-3q24qxsr author: Maru, Yoshiro title: Explanation of Metastasis by Homeostatic Inflammation date: 2016-02-02 words: 12156 flesch: 41 summary: key: cord-022136-3q24qxsr authors: Maru, Yoshiro title: Explanation of Metastasis by Homeostatic Inflammation date: 2016-02-02 journal: Inflammation and Metastasis DOI: 10.1007/978-4-431-56024-1_15 sha: doc_id: 22136 cord_uid: 3q24qxsr If inflammation caused by either non-self or self molecules can disseminate throughout the body and inflammatory sites actively allow entry of circulating tumor cells and assist regrowth, then circulating tumor cells metastasize to the sites of inflammation. If inflammation caused by either non-self or self molecules can disseminate throughout the body and inflammatory sites actively allow entry of circulating tumor cells and assist their regrowth, then circulating tumor cells metastasize to the sites of inflammation. keywords: acids; activation; activity; adipose; administration; ahr; amino; analysis; angiogenesis; angiotensin; anti; antibody; arthritis; atf3; atii; b16f10; background; bacteria; bearing; binding; binds; bone; breast; calcineurin; cancer; case; ccl2; ccr2; cd11b; cells; chap; circulation; club; conditions; critical; danger; days; defensive; dependent; development; dscr-1; eet; endogenous; endothelial; endothelial cells; enhanced; ephrin; epithelial; example; experiments; expression; factor; family; fig; form; gene; group; growth; high; homeostatic; human; huvec; il-6; important; increased; induced; inflammation; inflammatory; inhibited; injection; knockout; ko mice; leukocytes; levels; ligands; like; likely; liver; lps; lung metastasis; lungs; macrophages; mammary; manner; marrow; md-2; mdsc; mechanism; melanoma; metastasis; mice; migration; mmtv; model; molecules; monocytes; mouse; myd88; myeloid; negative; neutrophil; nfκb; non; organs; paracrine; patients; peptide; permeability; place; premetastatic; primary; production; proteins; pulmonary; pymt; rage; rankl; receptor; recruitment; regulation; response; results; role; s100a8; saa3; serum; signaling; sites; skin; space; specific; stimulated; stimulation; system; systemic; tail; tissue; tlr4; tnfα; toll; tone; transgenic; tumor; tumor cells; type; vascular; vegf; vein; weeks; wild cache: cord-022136-3q24qxsr.txt plain text: cord-022136-3q24qxsr.txt item: #53 of 105 id: cord-022252-9yiuuye3 author: Mims, Cedric A. title: Mechanisms of Cell and Tissue Damage date: 2013-11-17 words: 28876 flesch: 45 summary: Mycoplasma (see Table A .2) can grow in special cell-free media, but in the infected individual they generally multiply while attached to the surface of host cells. to host cells and tissues, but α-toxin is easily the most important one. keywords: ability; absorption; acid; action; activation; active; activity; acute; addition; adenylate; adp; affected; agent; amounts; animals; anthrax; antibodies; antibody; antigen; associated; bacteria; basis; binding; biological; black; blood; blood cells; botulinum; brain; camp; cases; cattle; cause; cells; central; certain; chains; changes; characterised; characteristic; children; cholera; cholera toxin; chronic; classical; clear; clinical; clostridium; cmi; coagulation; coli; common; complement; complexes; components; conditions; contaminated; crypt; cyclase; damage; days; death; deposition; destruction; determinants; development; diarrhoea; different; difficult; diphtheria; direct; disease; disease virus; effects; endogenous; endotoxin; enterocytes; enzymes; epithelial; evidence; example; experimental; exposure; expression; extent; factor; faeces; fatal; features; fever; fig; fluid; following; follows; food; form; formation; fragment; function; gangrene; gastroenteritis; genes; genetic; glomeruli; glomerulonephritis; gram; greater; group; growth; guinea; gut; haemolytic; haemorrhagic; healthy; heat; hepatitis; high; host; host cells; human; illness; immune; immune complexes; immunological; immunopathological; important; increase; incubation; individuals; infected; infection; inflammation; inflammatory; influenza; ingestion; inhibits; instance; intestine; intracellular; kidney; kill; large; lesions; lethal; levels; life; like; likely; lipid; little; liver; local; long; longer; loss; low; lps; lung; lysis; macrophages; major; man; massive; materials; means; measles; mechanism; membrane; mice; microbial; microorganism; mode; molecular; monkeys; mouse; mucosa; muscle; nature; necessary; necrosis; negative; nervous; new; normal; number; oedema; organism; origin; outer; particular; pathogenesis; pathogenicity; pathological; patients; perfringens; period; persistent; pertussis; phagocytes; physiological; pigs; place; plague; pneumonia; possible; potent; present; primary; produce; production; properties; protein; proteolytic; rashes; rate; reactions; receptor; red; release; respiratory; response; responsible; result; rise; role; salmonella; second; secondary; secretion; sequence; severe; sheep; shiga; shock; signs; similar; site; situation; skin; slow; small; space; species; specific; spores; staphylococcal; strains; streptococcal; stress; structure; studies; substances; subunit; surface; susceptible; swelling; symptoms; syndrome; synthesis; system; t cells; table; target; terminal; tetanus; throat; time; tip; tissue; toxicity; toxin; tract; treatment; tumour; type; typhoid; understood; variety; vascular; vessels; villi; villus; viral; virulence; virus; virus infections; viruses; vitro; vivo; water; way; weight; years cache: cord-022252-9yiuuye3.txt plain text: cord-022252-9yiuuye3.txt item: #54 of 105 id: cord-022888-dnsdg04n author: None title: Poster Sessions date: 2009-08-19 words: 189173 flesch: 41 summary: Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines. keywords: + +; + /+; + cells; 1,2; a*0201; a549 cells; ab t; ability; able; absence; absent; accessibility; accumulation; acid; actin; activated; active; activities; activity; acute; ad5; adaptive; adaptive immune; adaptor; addition; adenoviral; adhesion; adipocytes; adjuvant; administration; adp; adult; affect; affected; affinity; afp; agents; aggrecan; agonist; aim; aims; airway; akt; allele; allergens; allergic; alpha; alterations; altered; alternative; amino; amounts; analyse; analysis; anergy; animals; antagonist; antibodies; antibody; antibody response; antigen; antigen expression; antigen presentation; antigen receptor; antigen specific; antigenic; antiviral; apc; apcs; apoptosis; apoptotic cells; approach; appropriate; area; arthritis; asc; aspects; assay; associated; association; asthma; atherosclerosis; atp; attenuated; aureus; autoantibodies; autoantibody; autoimmune; autoimmunity; autologous; autophagy; autoreactive; available; avidity; b cells; b lymphocytes; b t; b-1 cells; b27; background; bacterial; baff; balb; basal; baseline; basis; basophils; bcg; bcl-2; bcr; berlin; beta; better; binding; biochemical; biological; biology; biopsies; blocking; blood; blood cells; blot; blotting; bone; boost; bowel; brain; breast; broad; burst; c mice; c57bl/6; caga; calcineurin; calcium; cancer cells; candidate; capable; capacity; carabin; carkl; cascade; cases; caspase; caspase-1; catalytic; cause; cbl; cd11b; cd14; cd152; cd16; cd19; cd1a; cd1d; cd25; cd28; cd3; cd36; cd4; cd40; cd45; cd5; cd56; cd69; cd8 +; cd8 cells; cd8 t; cd80; cd86; cd8a; cell activation; cell activity; cell antigen; cell biology; cell compartment; cell contact; cell culture; cell cycle; cell cytokine; cell cytotoxicity; cell death; cell degranulation; cell depletion; cell development; cell differentiation; cell epitopes; cell expansion; cell function; cell growth; cell help; cell homeostasis; cell hybridomas; cell immunity; cell influx; cell interaction; cell level; cell lines; cell lymphoma; cell lysates; cell maturation; cell membrane; cell number; cell phenotype; cell population; cell priming; cell production; cell proliferation; cell receptor; cell recognition; cell recruitment; cell repertoire; cell responses; cell signaling; cell sorting; cell stimulation; cell subsets; cell supernatant; cell surface; cell survival; cell tolerance; cell transfer; cell transplantation; cell types; cells cells; cells co; cells incubation; cells present; cells specific; cellular immune; center; central; certain; cfse; cgd; chain; challenge; changes; channels; characteristics; characterization; characterized; chemokines; chemotaxis; children; chimeric; chip; chitosan; cholesterol; chop10; chromatin; chromosome; chronic; cht; class; classical; clearance; cleavage; clinical; clones; close; cmv; cns; coated; cohort; colitis; collagen; colon; combination; combined; common; comparable; comparison; complement; complete; complex; complexes; components; composition; compounds; concentrations; conclusion; conditions; confocal; conjugate; consequences; conserved; consistent; constitutively; contact; context; contrary; contrast; contribute; contribution; control; control cells; control mice; controlling; conventional t; cord; coro1a; coronin-1; correlated; correlation; corresponding; course; cpg; criteria; critical; crohn; cross; crosstalk; crp; crt; crtam; crucial; csf; csk; ct26; ctl; ctla-4; ctls; cultured; current; cutaneous; cytokine; cytokine expression; cytokine levels; cytokine production; cytokine response; cytometry; cytoplasmic; cytoskeleton; cytosolic; cytotoxic t; damage; dasatinib; data; day; days; dcs; decreased; defective; defects; defense; deficiency; deficient cells; deficient mice; degradation; degree; delivery; delta t; dendritic cells; density; department; dependent; dependent cell; depleted; depletion; design; detail; detailed; detectable; detection; determination; determined; developmental; diabetes; diagnosis; differences; different; different cell; differential; differentiated; diminished; direct; disease; disorders; display; distinct; distribution; diverse; division; dna; domain; dominant; donors; dose; double; downregulation; downstream; draining; drb1; drugs; dsrna; dss; dynamics; early; early t; ebpb; ebv; effective; effector cells; effector t; effects; efficacy; efficient; efhd2; elements; elevated; elimination; elisa; elispot; embryonic; encoding; endosomal; endothelial; engagement; enhanced; enhancement; enhancing; enrichment; enzyme; eosinophils; epidermal; epidermis; epithelial cells; epithelium; eraap; erap1; erk1/2; erp57; erythematosus; escape; essential; ev71; evaluated; evaluation; events; evidence; example; exhibit; exogenous; exon; exosomes; expansion; experiments; exposed; exposure; expressed; expression; expression levels; expression system; extended; extent; extract; facs; factor; factor t; failure; family; far; fasl; fcgriib; features; feeding; female; ferritin; fetal; fibroblasts; fibrosis; findings; flow; fluorescence; foam cells; fold; following; formation; foxp3; fraction; fragment; free; frequencies; frequency; frequent; function; fusion; future; fviii; g t; galcer; gamma; gammadelta t; gastrointestinal; gcs; gd cells; gd t; gdcd8; gel; gene; gene expression; general; generation; genetic; genome; genomic; genotype; germany; gfp; glioma cells; glycoprotein; glycosylation; goal; good; gp120; grade; gram; grant; granules; granulocytes; granzyme; grb; greater; group; growth; gut; h5n1; ha-1; haart; hadv; half; hand; hcv; hdl; hdm; healing; healthy; heat; heavy; hek cells; helper cells; hematopoietic cells; heme; hepatitis; hi cells; high; high expression; high levels; high t; higher; highest; histamine; histological; history; hiv; hiv-1; hla; hla class; hmb; hmgb1; hospital; host; host immune; hours; hrs cells; hscs; hsp70; human b; human cd4; human cells; human peripheral; human t; humans; humoral; hybridomas; hypothesis; ibd; icam-1; icos; identification; iel; ifn; ifnar; ifnb; ifng; igg; igg1; igm; igsf4; ii t; il-10; il-12p40; il-1b expression; il-1ra; il-2; il-33; il-4; il-5; il-6; il-7; il-8; imaging; immature; immune activation; immune cells; immune regulation; immune response; immune system; immunity; immunization; immunized; immunocompetent cells; immunodeficiency; immunodominant; immunofluorescence; immunogenicity; immunoglobulin; immunological; immunology; immunomodulatory; immunoprecipitation; immunoproteasomes; immunosuppression; immunotherapy; impact; impaired; implications; important; important role; improved; inactivation; inactive; incidence; incorporation; increased; increasing; incubation; individuals; induced; induced cell; inducible; induction; infants; infected cells; infected mice; infection; infiltrates; infiltration; inflamed; inflammation; inflammatory; inflammatory cells; inflammatory cytokines; inflammatory immune; inflammatory response; influence; influenza; influx; inhibited; inhibition; inhibitory; inhibits; initial; initiation; injury; inkt; inkt cell; inkt17 cells; innate; innate immune; innate t; insights; institute; intact; intensity; interaction; interest; interesting; interference; interferon; interleukin; intermediate; internalization; intestinal; intracellular; intraepithelial; intranasal; introduction; invariant; investigation; involved; involvement; isoforms; isolated; isolation; isotype; italy; jab1; jam; jnk; jurkat cells; jurkat t; kda; keratinocytes; key; killer cells; killer t; killing; kinase; kinetics; kit; knock; knockdown; knockout; knowledge; ko mice; kupffer cells; laboratory; lack; lamina; langerhans cells; large; latent; later; lck; lcmv; leishmania; length; leprae; lesions; lethal; leukemia; leukemic cells; leukemic t; leukocytes; levels; ligand; ligation; light; like; likely; limited; lineage cells; lineages; link; lipid; listeria; little; liver; lmp2; lmp7; lnk; loaded; loading; local; localization; locus; long; loss; low cells; lower; lp(a; lpr; lps; lsec; lung; lupus; lymphoid cells; lymphoma; mab; mabs; macrophage cell; macrophages; mainly; maintenance; major; majority; malaria; male; malignant cells; manipulation; manner; mapk; marked; markers; marrow cells; mass; mast cells; matrix; maturation; mature; mature b; mature cells; mcl-1; mcmv; mcs; mdp; mdsc; mean; measles; measure; measurement; mechanisms; mediated; mediators; medical; medicine; medium; medullary; melanoma cells; members; membrane; memory b; memory cells; memory t; methods; mhc; mhc class; mhcii; mice; microarray; microbial; microcapsules; microenvironment; microglia; microscopy; migration; milk; minimal; minor; minutes; mirnas; mitochondrial; mixed; model; moderate; modified; modulation; molecular; molecules; monoclonal; monocytes; monocytic cells; monocytogenes; mononuclear cells; months; mortality; mothers; mouse; mouse t; mrna; mucosal; multiple; murine; murine t; mutant; mutations; mva; mycn; mycobacteria; myd88; myeloid cells; naive; naive t; nanoparticles; national; natural; naï; nck; ncs; necessary; necrosis; necrotic cells; need; nef; nef138; negative; neonatal; neopterin; nets; network; neuroblastoma cells; neuronal cells; neutralization; neutralizing; neutrophils; new; newborn; nfat; nfatc1; nfkb; nfxb; nitric; nk cell; nk t; nkg2d; nkt cells; nod mice; node t; nodes; normal; normal t; novel; ns3; nucleotide; null t; number; numerous; objectives; observation; observed; onset; opn; optimal; optimal t; order; organ; organization; origin; outcome; ova; ovalbumin; overall; overexpression; oxidative; oxide; p110; p14 t; p1c; p24; p38; p53; panel; parameters; parasite; parasitic; partial; participate; particles; particular; pathogenesis; pathogens; pathological; pathology; pathway; patients; pattern; pbmc; pcr; pd-1; pdc; peak; peptide; percentage; period; peripheral; peripheral blood; peritoneal; peritoneal cells; persistent; pge; pgp; phagocytes; phagocytosis; phase; phenomenon; phenotype; phosphatase; phosphorylation; physiological; pi3k; pivotal; pkc; place; placebo; plasma cells; play; plc; plus; pma; pneumoniae; point; polarization; polarized; pollen; poly(i; polyclonal; polymorphisms; pool; populations; position; positive cells; positive t; possibility; possible; post; potential; pparg; precursor; preliminary; prepared; presence; present study; presentation; presenting; pretreatment; prevents; previous; primary; primary cells; primary t; primed; priming; prior; process; processes; processing; producers; producing; production; products; profile; profound; progenitor cells; progenitors; program; progression; project; proliferative; prominent; promising; promoter; prone; properties; proportion; proteasome; protective; protein; protein expression; protein levels; protein production; proteolytic; protocol; provide; psoriasis; pta; ptx3; pulmonary; pulsed; purified; purpose; putative; pylori; quality; quantitative; quantity; question; rac1; range; rapid; rats; rbl-2h3 cells; reaction; reactive; real; rearrangements; recent; receptor expression; receptors; recipients; recognition; recombinant; recruitment; reduced; reg cells; region; regulated; regulation; regulators; regulatory cells; regulatory role; regulatory t; related; relationship; relative; release; relevance; relevant; remains; remission; repertoire; replication; reported; required; research; resident; resident cells; residues; resistance; respect; respiratory; responder; responsible; responsiveness; resting; restricted; results; reticulum; reverse; rhdv; rich; rise; risk; rma cells; rnai; robust; role; roquin; route; rsv; s1p; salivary; samples; samsn1; sarcoidosis; scanning; school; sciences; sclerosis; seasonal; second; secondary; secrete; secretion; secretory; selected; selection; selective; self; sensitive; sensitivity; separated; sepsis; sequence; sera; serum; severe; severity; sh3; shock; short; shrna; signaling; signals; significantly; similar; simultaneous; single cell; site; size; skin; slc; sle; sle patients; sly2; small; smurf2; snps; socs1; soluble; sortilin; sorting; source; spain; species; specific activation; specific antibodies; specific b; specific cd8; specific expression; specific immune; specific responses; specific role; specific t; spectrometry; spleen cells; splenic; splenocytes; splicing; spontaneous; src; ssc; stability; stable; stages; staining; standard; stat6; statistical; status; steady; stem cells; step; stimulated; stimulated cells; stimulation; stimulatory; stimuli; stimulus; strain; strategies; strategy; strength; stress; stromal cells; strong; structural; student t; studies; study; studying; subcellular; subcutaneous; subjects; subpopulations; subsequent; substantial; substrate; subtypes; subunit; successful; suffering; summary; supernatants; support; suppression; surface expression; surgery; surveillance; survival; survivin; susceptibility; susceptible; sustained; swap-70; swiprosin-1; switch; syk; symptoms; synapse; syndrome; synthesis; synthetic; system; systemic; t activation; t cells; t em; t h; t helper; t lineage; t lines; t lymphocytes; t reg; t test; tap1; tap2; tapasin; target cells; targeted; targeting; targets; tcr; tcrab; tcrgd; technique; technology; tecs; teff cells; terminal; terminus; terms; tested; tests; tgf; tgfb1; th1 cells; th17; th2; th2 cell; therapeutic; therapies; therapy; thymic; thymic cells; thymocytes; thymus; time; tissue; titers; tlr; tlr2; tlr3; tlr4; tlr7; tlr9; tlrs; tnc.1 cells; tnf; tnfa; tolerance; tolerogenic; toll; tool; total; trail; transcription; transcripts; transduction; transfer; transgenic; transgenic mice; transient; translocation; transmembrane; transport; treatment; tregs; trials; triggering; triggers; tuberculosis; tumor cells; tumors; tumour; turnover; type; type b; type mice; typical; tyrosine; u937 cells; ubiquitin; ulcerative; unclear; unconventional t; underlying; understanding; understood; uninfected; unique; united; university; unknown; untreated; upa; uptake; us3; useful; uty; vaccinated; vaccination; vaccine; vaccinia; vacv; values; variable; variants; variety; vascular; vector; vegf; venous cells; versus; vesicles; vg9vd2 t; vgamma9vdelta2 t; viral; virulent; virus; viruses; vitro; vivo; vivo t; vlps; volunteers; weeks; wehi231 cells; weight; western; whitney; wide; wild; wildtype; wnt; work; years; zfp36l1 cache: cord-022888-dnsdg04n.txt plain text: cord-022888-dnsdg04n.txt item: #55 of 105 id: cord-023026-2r84ndzv author: None title: Posters date: 2013-06-14 words: 138804 flesch: 38 summary: Levels of expression of NG2 mRNA and protein in mouse glial cells are regulated by the neurotransmitter glutamate and overexpression of cleaved fragments modulates protein expression in murine glial cells. Interestingly, when we analyzed the in vitro expression pattern of rCD300f in brain cells by Q-PCR and immunohistochemistry, in addition to the expected expression in microglial cells, we detected expression of CD300f in oligodendrocytes and neurons. keywords: -atpase; 24h; 3xtg; abcd1; ability; ablation; able; absence; abundant; accelerated; accumulation; acid; acidic; action; activated; activation; activators; activities; activity; acts; acute; acute brain; ad mice; addition; address; adenosine; adhesion; adjacent; administration; adult; adult brain; adult mice; adulthood; affected; affinity; aged; aged mice; ageing; agent; aggregates; aggregation; agonists; aim; akt; ald; alpha; alterations; altered; alternative; alzheimer; amounts; amplitude; amyloid; analysis; animals; antagonist; anti; antibodies; antibody; antigen; ao cells; apelin; apod; apoptosis; apoptotic; apparent; application; approach; aqp4; areas; artery; aspartate; aspects; assay; associated; association; astrocyte activation; astrocytes; astroglial; astroglial cells; astrogliosis; atp; attenuated; autoimmune; axonal; axons; background; barrier; basal; baseline; basis; bbb; bdnf; behavior; beneficial; bergmann; beta; better; bicarbonate; binding; biological; biology; blocking; blood; blot; body; bone; brain; brain barrier; brain cells; brain development; brain expression; brain function; brain injury; brain microglia; brain regions; brain slices; brain tissue; brainstem; c57bl/6; ca1; ca21; calcium; callosum; candidate; capable; capacity; cascade; cases; catenin; cause; cci; ccl2; cd11b; cd14; cd200r1; cd300f; cd45; cd68; cdk2; cell activation; cell adhesion; cell cultures; cell cycle; cell death; cell differentiation; cell lines; cell population; cell proliferation; cell surface; cell survival; cell types; cells; central; central nervous; cerebellar; cerebral; challenge; changes; channels; characteristics; characterization; characterized; chemokines; cholinergic; chronic; cis; clamp; classical; clearance; clinical; cns; cns cells; cns injury; cognitive; collagen; combination; common; communication; comparison; complex; complexes; components; concentration; conclusions; conditions; confocal; connexin; consequences; consistent; contact; context; contralateral; contrary; contrast; contribution; control; control cells; control mice; controlling; cord; cord cells; core; corpus; correlates; correlation; corresponding; cortex; cortical; cortical astrocytes; coupling; course; coverage; cpz; creb; creert2; critical; cross; crucial; cryab; csf; cultured astrocytes; cultured microglia; cultures; cuprizone; curcumin; current; cx30; cx32; cx3cr1; cx43; cx47; cxcl12; cycle; cytokines; cytometry; cytoplasmic; cytoskeleton; d2r; daily; damage; data; days; death; debris; decline; decreased; defects; deficient; deficient mice; deficits; degeneration; degradation; deletion; delivery; demyelinated; demyelinating; dendritic cells; densities; density; dentate; dependent; deposits; deprivation; derived; detailed; detectable; detrimental; development; diet; differences; different; different brain; different cell; differential; differentiation; diffusion; diminished; direct; disease; disorders; display; disruption; distal; distinct; distribution; diverse; dna; domain; dopa; dorsal; dose; double; dpakkr; dpi; drg; drosophila; drug; dsred; dye; dynamics; dysfunction; e.g.; eae; early; ebpb; ebpd; ecm; effect; effective; efficacy; efficient; egfp; electrical; electron; electrophysiological; elevated; embryonic; embryos; encephalomyelitis; encoding; endogenous; endothelial cells; energy; enhanced; environment; enzyme; ependymal cells; epilepsy; epileptic; erk; erk1/2; essential; events; evidence; evoked; examined; excitatory; excitotoxicity; exhibit; exosomes; expected; experiments; explants; exposed; exposure; expressed; expression; expression analysis; expression levels; extensive; extent; extracellular; eyes; facs; factors; failure; family; fast; fate; fatty; features; fibers; fibronectin; field; findings; flow; fluorescent; focus; fold; forebrain; formation; fraction; free; frequency; function; functional role; future; g93a; gaba; gabaergic; gain; ganglia; ganglion; gap; gbm; gdnf; gene; gene expression; general; generate; genetic; germany; gfap; gfap mice; gfp; glast; glaz; glial activation; glial cells; glial cultures; glioblastoma; glioma cells; global; glt-1; glucose; glutamate; glutamatergic; glutamine; glycogen; graft; group; growth; gsc; gscs; gyrus; hand; healthy; help; hemichannel; heterogeneity; high; higher; hippocampal; histological; homeostasis; hormone; host; hours; hrs; hspb5; hsvtk; human; human astrocytes; human brain; human microglia; hypertension; hypertrophy; hypothalamus; hypothesis; hypoxia; i.p; iba-1; iba1; identification; ifn; igg; iii; il-1b; il-1ra; il-33; il-6; il6; images; imaging; immature; immune cells; immunofluorescence; immunohistochemistry; immunological; immunoreactivity; immunostaining; impact; impaired; impairment; important; important role; improve; increase; incubated; incubation; individual; induced; inducible; induction; infiltration; inflammasome; inflammation; inflammatory; inflammatory activation; inflammatory cells; inflammatory response; influence; influx; inhibited; inhibition; inhibitory; inhibits; initial; initiation; injection; injured; injuries; injury; innate; inner; insight; intact; integrity; intensity; interaction; interest; interferon; interneurons; intrinsic; invasion; investigation; involved; involvement; ips cells; ischemic; isoforms; isolated; jun; key; kinase; kir4.1; knock; knockdown; knockout; knockout mice; knowledge; known; ko mice; labeling; lacking; lactate; large; lateral; layer; leads; learning; length; lentiviral; lesions; leukocytes; levels; ligand; light; like; like cells; likely; limited; line; lineage; lineage cells; lipid; lipopolysaccharide; lithium; littermates; little; live; local; localization; long; loss; lower; lpc; lps; ltp; lymphocytes; lysm; macrophages; main; maintenance; major; majority; male; mammalian; manner; mapk; marked; markers; marrow; mass; material; matrix; matter; maturation; mature; mbp; mcao; mcs; mct4; mean; measurements; mechanical; mechanisms; media; mediators; medium; member; membrane; memory; metabolic; metabolites; methods; mhc; mice; microarray; microenvironment; microglia; microglia activation; microglial cells; microglial processes; microglial response; microscopy; middle; migration; minocycline; mir-219; mir-302; mitochondrial; mixed; model; modifications; molecular; molecules; monocytes; months; morphological; morphology; motility; motor; mouse; mouse brain; mouse microglia; mouse model; mrna; ms patients; msc; msh; multiple; multipotent; murine; mutant; mutations; myelin; myeloid cells; naa; naag; na€; nbce1; necessary; nefiracetam; negative; neonatal; nerve; nervous; nervous system; nestin; networks; neural; neurite; neurodegenerative; neurogenesis; neurogenic; neuroinflammation; neurological; neuronal; neuronal activity; neuronal cells; neurons; neuropathic; neuropathological; neuroprotective; neurospheres; neurotransmitter; neurotrophic; new; nfjb; ng2 cells; niche; nitric; nmda; nodes; non; normal; normal brain; notch; novel; npcs; nrg; nscs; nuclear; nuclei; nucleus; number; objective; observations; observed; obtain; occlusion; occurring; oecs; ogd; oht; old; olfactory; oligodendrocytes; oligodendroglial; oligodendroglial cells; ols; ongoing; onset; opcs; open; optic; order; organotypic; osm; outcome; outer; outgrowth; overall; overexpression; oxidative; oxide; oxygen; p10; p2x; p2x4; p2y1; p75; pain; panx1; pap; parallel; parameters; parenchyma; particular; patch; pathogenesis; pathological; pathology; pathway; patients; pattern; pcr; peak; peptide; percentage; performance; perinatal; period; peripheral; perivascular; permanent; permeability; phagocytic; phagocytosis; pharmacological; phase; phenomenon; phenotype; phosphorylation; photon; physiological; physiology; plaques; plasma; plasmin; plasminogen; plasticity; play; plp; pluripotent; pns; pnv; point; population; positive astrocytes; positive cells; possibility; possible; post; postnatal; potassium; potential; precursor cells; precursors; preliminary; presence; present; present study; previous; primary; primary astrocytes; primary microglia; priming; prior; processes; processing; production; profile; profound; progenitor cells; progenitors; program; progression; proliferate; proliferation; prominent; promising; promoter; properties; proportion; protein; protein expression; protein levels; proteomic; protocol; pups; pure; purified; purinergic; purpose; putative; qpcr; quantification; quantitative; question; radial; range; rapid; rat astrocytes; rat brain; rate; rats; reaction; reactive; reactive astrocytes; reactive microglia; real; recent; receptor activation; receptor expression; receptors; recombined cells; recordings; recovery; recruitment; reduced; regenerative; regions; regulated; regulation; regulatory; related; relative; release; relevance; relevant; removal; remyelination; repair; reperfusion; reported; research; resident; resolution; respiratory; response; responsible; restricted; results; retinal; rise; robust; rodent; role; root; s100b; saline; samples; scar; schwann cells; sci; sciatic; sclerosis; second; secondary; secretion; sections; sedentary; selective; self; sensitive; sensitivity; sensory; serine; severe; sgcs; sham; sheath; short; shows; siglec; signaling; signals; significant; similar; single; single cell; sirt1; site; situ; size; sleep; slices; small; sod1; sodium; soluble; somatosensory; sorted; sorting; source; sox10; space; spatial; species; specific; specific cell; spinal; spinal cord; spinal microglia; spontaneous; sr101; sra; stable; stages; staining; state; status; stem cells; step; stimulated; stimulation; stimuli; strategies; strategy; stress; striatal; striatum; stroke; strong; structure; studies; study; subjects; subpopulation; subsequent; substances; substrate; subtypes; subunit; suitable; summary; support; suppression; surface; survival; sustained; svz; svz cells; symptomatic; symptoms; synapses; synaptic; synthase; synthesis; system; systemic; t cells; tace; tamoxifen; target; targeting; tau; technique; terc; term; terminal; test; tg mice; tg2; tgf; therapeutic; therapies; therapy; thickness; time; timp-1; tims; tissue; tlr2; tlr3; tlr4; tnf; tnfa; toll; tool; total; toxic; trafficking; transcription; transcripts; transfection; transgenic mice; transient; transmission; transplantation; transplanted; transporter; trauma; traumatic; treatment; trem2; trif; trkb; tumor; tumor cells; turn; type; type mice; typical; uller; unclear; undergo; underlying; understanding; understood; unique; united; university; unknown; untreated; uptake; values; variety; vascular; vector; vegf; vessels; viability; vitro; vivo; vlcfa; voltage; volume; vwm; water; weeks; weight; western; white; wild; wistar; wnt; work; wound; wt mice; yfp; young; zebrafish; zone; ıve cache: cord-023026-2r84ndzv.txt plain text: cord-023026-2r84ndzv.txt item: #56 of 105 id: cord-023935-o2ffxgnn author: Lorts, Angela title: Sepsis date: 2011-12-16 words: 11116 flesch: 34 summary: More recently, a polymorphism within the CD14 promoter gene (C to T transition at base pair -159) was identifi ed with a particular genotype over-represented among septic shock patients compared to healthy controls. It is believed that genetic differences among hosts are at least in part responsible for this variability in sepsis responses. keywords: absence; activation; addition; adhesion; administration; adults; agents; ammation; ammatory; ammatory response; anti; arterial; associated; bacteria; blood; capillary; cardiac; care; cascade; cation; cava; cell; cellular; children; circulating; clinical; coagulation; complex; consensus; criteria; critical; cytokines; defi; delivery; development; dysfunction; e.g.; early; effects; endotoxin; evidence; expression; factor; fl uid; following; function; gene; goal; gram; hemodynamic; host; identifi; iii; il-1; il-1ra; immune; important; infection; infl; infl ammatory; initial; innate; intravascular; key; kinase; levels; lps; molecular; molecules; mortality; multiple; negative; normal; number; numerous; organ; outcome; output; oxygen; pathogen; pathways; patients; pediatric; population; positive; presence; present; pressure; production; proinfl; protein; pulmonary; rate; receptor; recognition; refi; related; resistance; respiratory; response; resuscitation; risk; role; saturation; sepsis; septic; septic response; septic shock; severe; severe sepsis; shock; signifi; sirs; specifi; state; stimulation; studies; study; support; surface; systemic; therapeutic; therapy; time; tissue; tnf; toll; trials; uid; use; variation; vascular; vena; venous; volume cache: cord-023935-o2ffxgnn.txt plain text: cord-023935-o2ffxgnn.txt item: #57 of 105 id: cord-029488-l11ufs6k author: Tomita, Kengo title: Vascular endothelial growth factor contributes to lung vascular hyperpermeability in sepsis-associated acute lung injury date: 2020-07-21 words: 5101 flesch: 35 summary: Taken together, our results indicate that VEGF can contribute to the development of non-cardiogenic lung edema in sepsis-associated ALI due to increased VEGF secretion from pulmonary vascular endothelial cells through multiple MAPK-dependent pathways. 5 Schematic diagram of the participation of VEGF released from pulmonary vascular endothelial cells in noncardiogenic high vascular permeability pulmonary edema associated with LPS-induced ALI. keywords: activation; acute; ali; animals; anti; antibody; ards; bal; bevacizumab; cardiogenic; cells; challenge; clp; control; development; edema; elisa; endothelial; epithelial; et al; expression; factor; fig; fluid; gapdh; growth; high; hpmec; human; hyperpermeability; ifn; igm; increase; induced; inhibitor; injury; jnk; kinase; levels; lps; lung; mapk; mice; microvascular; model; monoclonal; mouse; mrna; non; organ; p38; pcr; permeability; plasma; protein; pulmonary; receptors; respiratory; role; sepsis; septic; sham; signaling; significant; st1.6r; study; surgery; time; tissues; treatment; usa; vascular; vascular endothelial; vascular permeability; vegf; vegfr1 cache: cord-029488-l11ufs6k.txt plain text: cord-029488-l11ufs6k.txt item: #58 of 105 id: cord-029969-1fa8hk2n author: Ge, Xin title: Lycorine attenuates lipopolysaccharide-induced acute lung injury through the HMGB1/TLRs/NF-κB pathway date: 2020-08-01 words: 4673 flesch: 46 summary: However, compared with LPS group, the severity of alveolar congestion, alveolar wall thickening, and edema in LPS + lycorine groups was decreased (Fig. 1a) . The lung injury score in LPS + lycorine groups was lower than that in LPS group (Fig. 1a , P < 0.05). keywords: acid; acute; ali; alveolar; anti; cells; china; control; effect; expression; factors; fig; glycyrrhizic; group; hmgb1; il-1β; il-6; induced; inflammation; inflammatory; injury; iκbα; levels; lipopolysaccharide; lps; lps group; lung; lung injury; lycorine; mda; mice; min; oxidative; p65; pathway; protein; response; results; sections; significant; stress; studies; superscript; tissues; tlr4; tlr5; tlrs; tnf; treatment cache: cord-029969-1fa8hk2n.txt plain text: cord-029969-1fa8hk2n.txt item: #59 of 105 id: cord-030385-btf502ju author: Sun, Zhiheng title: 17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB date: 2020-07-22 words: 5878 flesch: 52 summary: Shock Effects of gender on the severity of sepsis Sexual dimorphism in bacterial infections Gender differences in trauma, shock and sepsis Sex and severe sepsis NFkappaB is a key player in the crosstalk between inflammation and cardiovascular diseases Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines NFkappaB affects estrogen receptor expression and activity in breast cancer through multiple mechanisms An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells Despite inhibition of nuclear localization of NF-kappa B p65, c-Rel, and RelB, 17-beta estradiol up-regulates NF-kappa B signaling in mouse splenocytes: the potential role of Bcl-3 BCG-induced trained immunity in NK cells: role for non-specific protection to infection Trained immunity: a new avenue for tuberculosis vaccine development Targeting SHIP-1 in myeloid cells enhances trained immunity and boosts response to infection The impact of sex hormones on BCG-induced trained immunity mTOR-and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells-novel qualification markers for chronic disease risk factors and conditional DAMPs Severe sepsis and septic shock Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Trained immunity: a smart way to enhance innate immune defence Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes RelB regulation of chemokine expression modulates local inflammation RelB cellular regulation and transcriptional activity are regulated by p100 Year in review in Intensive Care Medicine, 2008. In order to examine the effect of estradiol on trained immunity, we decided to pre-treat the macrophage cell lines with estradiol before trained immunity model. keywords: bcg; bmdms; body; cell; china; coli; concentration; cytokines; data; differences; different; early; effect; ers; estradiol; estrogen; experiments; expression; f4/80; female; female mice; figure; gender; glucan; group; immune; immunity; infection; inflammatory; innate; j774; kidney; level; lines; lps; lung; macrophage; males; mice; min; model; nfκb; non; nuclear; nucleus; ovx; p65; paired; pathway; pbs; phenotype; plates; polarization; protein; raw264.7; relb; response; results; role; samples; sepsis; serum; severe; signaling; significant; student; studies; study; test; tnfα; translocation; usa cache: cord-030385-btf502ju.txt plain text: cord-030385-btf502ju.txt item: #60 of 105 id: cord-032181-gmcugd8h author: Song, Jian-Xin title: Main Complications of AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 words: 51195 flesch: 34 summary: If liver disease patients have other lung diseases (such as chronic bronchitis, emphysema and pneumonia, and pleural effusion, etc.), then significant respiratory symptoms may occur. in liver cirrhosis patients with ascites that paracentesis should be performed after admission to determine whether SBP exist. keywords: aaa; abdominal; ability; abnormal; abnormalities; absorption; acid; acidosis; activated; activation; active; activity; acute; acute liver; addition; administration; aechb; agents; albicans; albumin; aldosterone; alkalosis; alveolar; amino; ammonia; analysis; angiography; anti; antibiotics; antibody; anticoagulation; antimicrobial; arterial; arterial blood; ascites; aspergillosis; aspergillus; associated; bacterial; bacterium; barrier; base; basic; bcaa; bile; biliary; binding; bleeding; blood; blood ammonia; blood cells; blood coagulation; blood flow; body; brain; broad; candida; capillaries; cardiac; cases; cause; cavity; cd14; cells; central; cerebral; chain; changes; characteristics; chest; chronic hepatitis; chronic liver; circulation; cirrhosis; cirrhotic patients; clear; clearance; clinical; clinical manifestations; clotting; coagulation; coagulation factors; coagulopathy; coli; coma; combination; common; compensatory; complement; complex; complicated; complications; concentration; conditions; control; correlation; count; creatinine; criteria; critical; culture; current; cytokines; damage; data; days; death; decline; decreased; deep; defense; deficiency; degree; dependent; detoxification; development; diagnosis; diarrhea; dic; different; difficult; diffuse; diffusion; dilatation; direct; diseases; disorder; disturbance; diuretics; dose; drugs; dysfunction; early; edema; effect; effective; efficacy; electrolyte; elevated; encephalopathy; endogenous; endothelial; endotoxemia; endotoxin; energy; epithelial; esophageal; etc; evidence; examination; excretion; expression; extracellular; factors; fdps; features; fever; fibrin; fibrinogen; fibrinolysis; filtration; flora; flow; fluid; following; formation; frequency; function; fungal; fungal infection; gaba; gastrointestinal; generation; glutamate; glutamine; gram; growth; gut; hco; heart; help; hemorrhage; hemostasis; heparin; hepatic; hepatic encephalopathy; hepatitis b; hepatitis patients; hepatocytes; hepatopulmonary; hepatorenal; herpes; high; higher; history; hospital; host; hps; hps patients; hrs; human; hyperfibrinolysis; hypertension; hypokalemia; hyponatremia; hypoxemia; hypoxia; ietm; iii; imbalance; immune; immunity; impaired; important; improved; improvement; incidence; increase; indicators; induced; infection; inflammation; inflammatory; inhalation; inhibit; inhibition; initial; injury; innate; insufficient; internal; international; intestinal; intrahepatic; intrapulmonary; intravascular; intravenous; invasive; involved; ischemia; jaundice; key; kidney; known; kupffer; laboratory; lack; lactulose; large; lead; lesions; levels; life; like; limited; lipid; lipopolysaccharide; liver; liver cells; liver cirrhosis; liver damage; liver disease; liver failure; liver function; liver injury; liver transplantation; local; long; loss; low; lower; lps; lungs; macrophages; mainly; major; management; manganese; manifestations; massive; means; mechanisms; medical; membrane; mental; metabolic; methods; mild; minimal; mmhg; mmol; mods; molecular; molecules; mortality; mucosal; multiple; muscle; natural; nausea; necessary; necrosis; need; negative; nerve; nervous; neutrophil; nevus; new; nitric; non; normal; nosocomial; number; obvious; occurrence; onset; oral; organ; osmotic; output; overt; oxide; oxygen; oxygenation; paco; pain; pao; partial; pathogenesis; pathogens; pathological; pathway; patients; people; performance; period; peripheral; peritonitis; permeability; phagocytosis; physiological; plasma; plasminogen; platelet; pleural; pneumonia; poor; portal; portosystemic; position; positive; possible; potassium; potential; practice; present; pressure; prevention; primary; primary liver; process; production; products; prognosis; progressive; prospective; protein; prothrombin; pss; pulmonary; pulmonary vascular; randomized; rate; reaction; recent; receptor; recognition; reduced; refractory; related; release; removal; renal; renal blood; renal failure; renal function; reports; research; resistance; respiratory; response; results; rifaximin; risk; role; sbp; secondary; secretion; sensitivity; sepsis; septic; serum; severe hepatitis; severe liver; severity; shock; short; shunt; significant; signs; sirs; sites; skin; small; sodium; soluble; specific; spectrum; spider; splanchnic; spontaneous; sputum; stage; stage liver; stool; stress; structure; studies; study; substances; surface; survival; symptoms; syndrome; synthesis; system; systemic; tendency; tenderness; terlipressin; term; tests; therapeutic; therapy; thrombosis; time; tips; tissue; tnf; total; toxic; toxins; tract; tract infection; transjugular; translocation; treatment; trial; tuberculosis; type; type-1; upper; uptake; urea; urinary; urine; value; variety; vascular; vasodilation; vein; venous; ventilation; vessels; viral; virus; vitamin; volume; vomiting; water; weight; xiii; years cache: cord-032181-gmcugd8h.txt plain text: cord-032181-gmcugd8h.txt item: #61 of 105 id: cord-032564-0t5lr4z9 author: Moin, Abu Saleh Md title: Pro-fibrotic M2 macrophage markers may increase the risk for COVID19 in type 2 diabetes with obesity()() date: 2020-09-16 words: 1054 flesch: 32 summary: Moreover, it is also possible that, apart from alveolar macrophages, other cellular sources, for example lung epithelial cells [16] , arterial smooth muscle cells Commentary: COVID-19 and obesity: exploring biologic vulnerabilities, structural disparities, and weight stigma Pulmonary postmortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages The chemokine system in diverse forms of macrophage activation and polarization A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18 Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese Determinants of serum concentrations of lipopolysaccharide-binding protein (LBP) in the adult population: the role of obesity Lipopolysaccharide-binding protein and CD14 are increased in the bronchoalveolar lavage fluid of smokers Concentrations of lipopolysaccharide-binding protein, bactericidal/permeability-increasing protein, soluble CD14 and plasma lipids in relation to endotoxaemia in patients with alcoholic liver disease Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm: implications for a role of LBP in intracellular LPS-signaling MMP9 modulates tight junction integrity and cell viability in human airway epithelia Regulation of matrilysin expression in airway epithelial cells by keywords: activation; alveolar; binding; cells; elevated; epithelial; fibrosis; lbp; levels; lipopolysaccharide; lps; macrophages; mmp9; obesity; ot2d; patients; plasma; protein; role; study; subjects; tgf cache: cord-032564-0t5lr4z9.txt plain text: cord-032564-0t5lr4z9.txt item: #62 of 105 id: cord-103496-8tq78p2z author: Wang, Ting title: RAC1 nitration at Y32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury date: 2020-11-13 words: 5865 flesch: 40 summary: Using a murine model of ALI induced by intratracheal installation of LPS we found that NipR2 successfully prevented Rac1 nitration and Rac1 inhibition, and more importantly attenuated pulmonary inflammation, reduced lung injury and prevented the loss of lung function. As NipR2 also reduces sepsis induced ALI in the mouse lung, we conclude that Rac1 nitration is a therapeutic target in ALI. keywords: activation; activity; acute; ali; alveolar; analysis; antibody; ards; barrier; blot; buffer; cell; data; disease; disruption; endothelial; endotoxin; figure; flap; function; generation; group; gtpases; hlmvec; human; inflammation; inhibition; injury; integrity; lipopolysaccharide; lps; lung; maldi; mass; mice; microvascular; min; model; nipr2; nitrated; nitration; nitric; oxidative; oxide; oxygen; paec; patients; peptide; permeability; peroxynitrite; phosphorylation; post; protein; pulmonary; purified; r n; rac1; reactive; recombinant; region; regulation; respiratory; rhoa; role; sepsis; sigma; signaling; similar; site; species; stress; structure; study; target; therapeutic; therapy; tissue; translational; tyrosine; u r; volume; western cache: cord-103496-8tq78p2z.txt plain text: cord-103496-8tq78p2z.txt item: #63 of 105 id: cord-103592-lkngp2u6 author: Bachmaier, Kurt title: Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury date: 2020-07-02 words: 6330 flesch: 36 summary: We consistently found that CD11b expression levels on PMN in peripheral blood, lung, and liver, were greater on ANP high PMN than on ANP low PMN ( Figure 1E ), and lung ANP high PMN showed the highest CD11b expression ( Figure 1E) , indicating a higher level of inflammatory activation of the ANP high PMN subset. Importantly, we found that CCR1 receptor cell surface expression, consistent with the mRNA data, was significantly greater on lung ANP high PMN than in ANP low PMN before and 3h, 6h, and 12h after LPS stimulation ( Figure 3B ). keywords: activation; ali; alpha; anp; anp high; anp low; at2(nfatc1; bacterial; beta; ccl3; cd11b; cd40(tnfrsf5; cells; chain; challenge; chemokine; class; clp; controls; cxcl2; cxcr4; damage; data; defense; disease; distinct; endotoxin; expression; figure; function; gamma; greater; heterogeneity; high; high pmn; host; i.v; ifn; il-1; il-2r; immune; infection; inflammation; inflammatory; injury; integrin; liver; low; low pmn; lps; lung; ly6; mapk; mediators; mhc; mice; mortality; mrna; neutrophils; p38; panp; patients; piceatannol; pmn; polymicrobial; production; pulmonary; receptors; recipient; reduced; response; ros; saline; sepsis; severe; specific; subset; supplemental; syk; targeting; tgf; tissue; treatment; uptake cache: cord-103592-lkngp2u6.txt plain text: cord-103592-lkngp2u6.txt item: #64 of 105 id: cord-252855-xtsnlu1f author: Drago-Serrano, Maria Elisa title: Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections date: 2017-03-01 words: 12051 flesch: 25 summary: Therefore, all findings on Lf activities suggest that Lf and Lfcins can be of potential use as antimicrobial and anti-inflammatory compounds, either alone or as adjuncts to conventional antibiotics and drugs. The reason for the lack of bLf protecting effect in these viral infection mice models is unknown, but possible explanations could be related to timing, dosing, and route of bLf administration. keywords: ability; action; activation; activities; activity; addition; administration; antibacterial; antibiotics; antimicrobial; antiviral; apo; assays; associated; bacterial; bcg; binding; blf; bovine; bovine lactoferrin; c3h; cells; challenge; clinical; coli; combination; control; crohn; cultures; cytokines; damage; decrease; development; different; disease; effects; elicitation; endotoxemia; epithelial; escherichia; evidence; experimental; expression; findings; function; gland; glycoprotein; growth; gut; hepatitis; histolytica; hlf; holo; homeostasis; human; human lactoferrin; ifnγ; il-6; il-8; immune; immunity; immunomodulatory; impact; induced; infected; infection; inflammation; inflammatory; inflammatory response; innate; intestinal; intraperitoneal; invasive; iron; lactoferrin; levels; lfchimera; lipopolysaccharide; liver; load; low; lps; lung; macrophages; mammary; mastitis; mechanisms; mice; milk; model; modulation; modulatory; mucosal; murine; neutrophils; oral; pathogens; pathways; patients; peptide; post; potential; pro; production; properties; protective; protein; pulmonary; pylori; receptors; recombinant; regulation; resolution; respiratory; response; results; role; route; secretions; sepsis; serum; sites; small; spleen; staphylococcal; strain; studies; study; systemic; th1; therapeutic; tissue; tlr4; tnfα; tract; transferrin; transgenic; treatment; tuberculosis; use; vaccine; viral; virus; vivo cache: cord-252855-xtsnlu1f.txt plain text: cord-252855-xtsnlu1f.txt item: #65 of 105 id: cord-252859-zir02q69 author: Chung, T. Philip title: Molecular Diagnostics in Sepsis: From Bedside to Bench date: 2006-09-11 words: 5746 flesch: 41 summary: Using mouse spleen samples for gene expression analysis, we were able to classify the samples as CLP or Sham with 96.0% accuracy, estimated using cross-validation. Because the clinical use of gene expression analysis using splenic tissue is severely limited, we explored next the use of circulating blood for class prediction in our mouse models. keywords: accuracy; analysis; animals; anova; antibiotics; batch; blood; cell; changes; classification; classifier; clinical; clp; common; contrast; control; counts; cross; data; diagnosis; differences; differential; dysfunction; effects; experimental; expression; fig; gene; gene expression; genechip; group; human; infection; inflammation; inflammatory; injury; leave; lipocalin; lps; mice; microarray; model; molecular; mortality; mouse; non; normal; number; organ; pathway; patients; pca; phenotype; prediction; probe; profiles; profiling; protein; reports; response; rna; samples; sepsis; septic; set; sets; sham; small; specific; spleen; sterile; studies; study; systemic; test; time; tissue; training; treatment; validation cache: cord-252859-zir02q69.txt plain text: cord-252859-zir02q69.txt item: #66 of 105 id: cord-255578-0ltb9dpa author: Li, Xiangru title: Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway date: 2020-06-19 words: 6409 flesch: 50 summary: The quantity of red blood cells in Cfhr1 −/− mice at 12 h after LPS challenge was dramatically lower than the wild-type mice, which indicates that much more congestion could happen in Cfhr1 deletion mice (Figure 6G) . As expected, Cfhr1 −/− mice showed more deposited C3b on LPS ( Figure 4C) . keywords: activation; activity; ahus; alternative; analysis; animal; anti; antibody; atypical; beijing; blood; blotting; buffer; c3a; c3b; c5a; cells; cfhr1; challenge; china; complement; control; convertase; data; deficiency; deletion; different; diluted; edta; effect; equal; factor; fhr; fhr-1; fhrs; figures; function; gene; genotypes; group; higher; homolog; human; il-1β; induced; infection; inflammation; injury; kidney; knockout; level; lps; mechanism; mice; model; mouse; murine; pathway; pbs; plasma; protein; rabbit; rat; regulation; related; results; role; sepsis; sequence; serum; severe; significant; specific; study; syndrome; system; time; tnf; type; usa; vivo; western; wild; −/− cache: cord-255578-0ltb9dpa.txt plain text: cord-255578-0ltb9dpa.txt item: #67 of 105 id: cord-257092-r11cgpvs author: Wu, Fengjiao title: CXCR2 is essential for cerebral endothelial activation and leukocyte recruitment during neuroinflammation date: 2015-05-21 words: 6739 flesch: 44 summary: Reduced expression of these molecules was observed in CXCR2 −/− endothelial cells (Fig. 7F) . CXCR2 −/− mice (on the C57BL/6J background) were purchased from the Jackson Laboratory (Bar Harbor, ME, USA). keywords: activation; adhesion; analysis; astrocytes; barrier; bbb; blood; blotting; bone; brain; cells; cerebral; chemokine; chimeric; cns; culture; cxcl1; cxcr2; data; deficiency; endothelial; endothelial cells; essential; expression; fig; following; i.c.v; infiltration; inflammation; inflammatory; injection; interactions; intravital; leukocyte; leukocyte recruitment; levels; lps; lps injection; marrow; mice; microglia; microscopy; microvessels; min; molecules; mouse; mrna; neutrophil; pbs; pcr; primary; protein; receptor; recruitment; response; results; role; saline; sb225002; selectin; sem; significant; study; system; talen; time; tnf; type; usa; vcam-1; vessels; western; wild; −/− cache: cord-257092-r11cgpvs.txt plain text: cord-257092-r11cgpvs.txt item: #68 of 105 id: cord-261367-i1n8x0uc author: Hwang, Ji Young title: Inducible Bronchus–Associated Lymphoid Tissue (iBALT) Attenuates Pulmonary Pathology in a Mouse Model of Allergic Airway Disease date: 2020-09-25 words: 7628 flesch: 40 summary: To isolate lung epithelial cells, we perfused the lungs with PBS containing 0.05 mM EDTA (Lonza), instilled with 1 ml Dispase (160 µg/ml; Corning), and incubated them in a shaker at 37 • C for 15 min. Using forceps, lungs were torn into small pieces, and put back in the shaker at 37 • C for an additional 30 min in Dispase (160 µg/ml; Corning) and DNaseI (250 µg/ml; Worthington Biochemical). Lung epithelial cells were sorted with FACSAria II (BD Biosciences) located at University of Alabama at Birmingham Flow Cytometry Core Facility. keywords: accumulation; airway; allergen; allergic; altered; anti; antigen; areas; asthma; biosciences; bronchus; cd4; cells; challenge; chronic; context; control; control mice; cytokines; data; days; development; difference; disease; donor; effector; eosinophils; epithelial; exposure; expression; figure; formation; frequency; groups; ibalt; ibalt mice; il-4; immune; immunity; inducible; inflammation; inflammatory; invitrogen; lps; lungs; lymphoid; lymphoid tissue; mice; mouse; mrna; naïve; neonatal; neonates; number; organs; ova; pathology; pbs; possibility; presence; priming; production; pulmonary; recruitment; reduced; regulatory; relative; responses; rheumatoid; sections; sensitization; sensitized; sigma; similar; specific; t cells; test; th2; th2 cells; tissue; total; tregs; virus cache: cord-261367-i1n8x0uc.txt plain text: cord-261367-i1n8x0uc.txt item: #69 of 105 id: cord-264145-73e61rlq author: Belančić, Andrej title: Gut microbiome dysbiosis and endotoxemia - Additional pathophysiological explanation for increased COVID-19 severity in obesity date: 2020-09-18 words: 1329 flesch: 12 summary: Taking everything into consideration, it is very likely that gut microbiome dysbiosis and endotoxemia represent the additional pathophysiological explanation for increased COVID-19 severity in obesity. Taking everything into consideration, it is very likely that gut microbiome dysbiosis and endotoxemia represent the additional pathophysiological explanation for increased COVID-19 severity in obesity. keywords: additional; bacteroidetes; covid-19; diet; dysbiosis; endotoxemia; explanation; fat; gut; human; immunoinhibitory; immunosilent; individuals; intestinal; lipid; lps; mechanisms; microbiome; obesity; pathophysiological; permeability; proinflammatory; severity; stress; subtypes cache: cord-264145-73e61rlq.txt plain text: cord-264145-73e61rlq.txt item: #70 of 105 id: cord-270213-ygb64yxc author: Williams, Alexander T. title: Control of systemic inflammation throughearly nitric oxide supplementation with nitric oxide releasing nanoparticles date: 2020-10-02 words: 2309 flesch: 23 summary: 477 478 Conclusion 479 Pathogenetic Mechanisms of Septic Shock 506 Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and 507 associated costs of care Epidemiology of severe sepsis Severe Sepsis and Septic Shock Sepsis and endothelial permeability Novel therapies for microvascular permeability in 515 sepsis The microcirculation is the motor of sepsis Severe abnormalities in microvascular perfused vessel density are associated 520 to organ dysfunctions and mortality and can be predicted by hyperlactatemia and 521 norepinephrine requirements in septic shock patients Microvascular resuscitation as a therapeutic goal in 523 severe sepsis 525 Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock 526 resuscitation using polyethylene glycol-albumin-and hydroxyethyl starch-based plasma 527 expanders B. & Intaglietta, M. Microcirculation: Its Significance in Clinical and Molecular Microcirculation: Physiology, Pathophysiology, and 532 Clinical Application Clinical review: Clinical imaging of the 534 sublingual microcirculation in the critically ill -where do we stand? LPS/TLR4 signal transduction pathway Animal Models of sepsis: setting the stage Sustained release nitric oxide releasing nanoparticles: characterization of a novel 542 delivery platform based on nitrite containing hydrogel/glass composites A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: 546 Sustained vascular response 548 Sustained release nitric oxide from long-lived circulating nanoparticles. Medical care costs related to sepsis treatment add up to 68 approximately $20 billion in the United States. keywords: animals; blood; cell; changes; clinical; control; cytokine; delivery; disruption; dysfunction; endothelial; endotoxemia; flow; glycocalyx; induced; inflammatory; lps; macrophage; microcirculation; microvascular; nanoparticles; nitric; nps; organ; oxide; permeability; response; role; sepsis; septic; severe; shock; study; survival; sustained; syndrome; systemic; target; tissue; treatment cache: cord-270213-ygb64yxc.txt plain text: cord-270213-ygb64yxc.txt item: #71 of 105 id: cord-273594-vmbhok1u author: Sichelstiel, Anke title: Targeting IL-1β and IL-17A Driven Inflammation during Influenza-Induced Exacerbations of Chronic Lung Inflammation date: 2014-06-11 words: 5628 flesch: 36 summary: Overall, blockade of IL-17A and IL-1b could be valuable therapeutic options for future treatment of viral induced exacerbations of chronic lung inflammation. In order to investigate the role of IL-1b during COPD exacerbations we utilized a model of LPS and elastase induced chronic lung inflammation, followed by infection with influenza in wild type or IL-1b deficient mice. keywords: absence; acute; airways; anakinra; anti; balb; c57bl/6; cells; chronic; cigarette; control; copd; cytokines; data; day; deficient; development; disease; early; elastase; emphysema; exacerbations; exposure; expression; factor; figure; il-17a; il-1b; il-6; induced; induction; infection; inflammation; inflammatory; influenza; key; levels; line; lps; lung; mechanisms; mice; model; mouse; neutrophil; observed; obstructive; patients; peak; phase; post; production; pulmonary; receptor; recruitment; reduced; replication; resistance; respiratory; response; role; signaling; smoke; study; therapeutic; tnfa; treatment; viral; virus cache: cord-273594-vmbhok1u.txt plain text: cord-273594-vmbhok1u.txt item: #72 of 105 id: cord-280482-o887a7q9 author: Xu, Suming title: Transgenic Mice Expressing MCP-1 by the Urothelium Demonstrate Bladder Hypersensitivity, Pelvic Pain and Voiding Dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study date: 2016-09-29 words: 4141 flesch: 38 summary: Supporting Information S1 Monocyte chemoattractant protein-1 (MCP-1): an overview Mycobacterium bovis bacillus Calmette-Gué rin (BCG) induces human CC-and CXC-chemokines in vitro and in vivo Wound healing in MIP-1alpha (-/-) and MCP-1(-/-) mice Mice lacking MCP-1 have enhanced susceptibility to an interstitial polymicrobial infection due to impaired monocyte recruitment Impaired monocyte migration and reduced type 1 (TH1) C-C chemokine receptor 2 knockout mice Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study Differential profile analysis of urinary cytokines in patients with overactive bladder Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α as possible biomarkers for the chronic pelvic pain syndrome Recruitment of bone marrow derived cells to the bladder after bladder outlet obstruction Urinary concentration and tissue messenger RNA expression of monocyte chemoattractant protein-1 as an indicator of the degree of hydronephrotic atrophy in partial ureteral obstruction Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation MCP-1-induced histamine release from mast cells is associated with development of interstitial cystitis/bladder pain syndrome in rat models Chronic pelvic allodynia is mediated by CCL2 through mast cells in an experimental autoimmune cystitis model Diagnosis and treatment of interstitial cystitis/bladder pain syndrome: AUA guideline amendment A tissue-specific promoter that can drive a foreign gene to express in the suprabasal urothelial cells of transgenic mice Vectors for high-level expression of cDNAs controlled by tissuespecific promoters in transgenic mice Urinary bladder epithelium antigen induces CD8+ T cell tolerance, activation, and autoimmune response Animal models of urologic chronic pelvic pain syndromes: Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation Modulating bladder neuro-inflammation: RDP58, a novel anti-inflammatory peptide, decreases inflammation and nerve growth factor production in experimental cystitis Role of inflammation in bladder function and interstitial cystitis Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Although our data indicate the presence of increased pelvic pain sensitivity, we will continue demonstrating bladder pain by using more specific methods such as the bladder distention-evoked visceromotor response (VMR) method [22] . keywords: animal; baseline; bladder; bps; c57bl/6; cages; cells; changes; chemoattractant; chronic; control; cystitis; days; dna; dose; dysfunction; elevated; epithelium; expression; fig; frequency; gene; habits; induction; infiltration; inflammation; inflammatory; interstitial; intravesical; lps; mcp-1; mice; micturition; model; monocyte; mouse; mrna; novel; noxious; pain; pbs; pcr; pelvic; promoter; protein-1; reduced; research; response; sequence; significant; single; study; sub; syndrome; table; transgenic; treatment; type; upii; urinary; urine; uro; voiding; volume; wild cache: cord-280482-o887a7q9.txt plain text: cord-280482-o887a7q9.txt item: #73 of 105 id: cord-280850-lku2g69k author: Zhang, Shidong title: Aqueous extract of Bai-Hu-Tang, a classical Chinese herb formula, prevents excessive immune response and liver injury induced by LPS in rabbits date: 2013-08-26 words: 3851 flesch: 41 summary: It showed centrilobular necrosis, infiltration of immunity cells (such as macrophages and lymphocytes) into portal tract and sinusoid, hepatocytes ballooning, necrosis, and disintegration. In this study, the results of immunoglobulins and T cell subpopulations showed that humoral immunity mediated by B cells was activated by LPS without CD 4+ cell (Th cells) increase, but cell immunity carried out by CD 8+ cells (Tc cells) was inhibited by LPS. keywords: adaptive; animals; anti; bht; blood; body; cells; china; chinese; co.; control; cytokines; damage; data; disease; dysfunction; excessive; experimental; expression; febrile; fever; fig; formula; gene; il-10; il-6; immune; immunity; important; inflammatory; injection; innate; lbp; like; lipopolysaccharide; liver; lps; manufacturer; medicine; model; pattern; pcr; rabbits; receptors; research; response; results; rna; role; serum; study; syndrome; system; tang; tcm; time; tlr4; tnf; toll; traditional; treatment cache: cord-280850-lku2g69k.txt plain text: cord-280850-lku2g69k.txt item: #74 of 105 id: cord-282336-zvc04s39 author: Choudhary, Ishita title: Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice date: 2020-09-02 words: 7920 flesch: 40 summary: These phenotypes were shown to be essentially completely prevented in TTP KO mice with either TNF receptor deficiency, or when TTP KO mice were treated with anti-TNF antibodies (5) . These increases were associated with an increased injury to the pulmonary vascular barrier, as depicted by the presence of red blood cells in the cytospins prepared from the BALF fluid of TTP KO mice ( Figure 1E ; right panel, black arrow) versus control LPS-challenged WT mice ( Figure 1E ; left panel). keywords: acute; airspace; ali; alveolar; analysis; ards; arrow; balf; bar; bone; cells; cellular; challenge; characterized; chemoattractants; chimeras; consolidation; control; counts; cre; csf; data; distress; edema; endotoxin; epithelial; exaggerated; expression; factor; figure; flox; green; groups; higher; hpcs; immune; induced; infiltration; inflammation; inflammatory; injury; irradiated; ko mice; left; levels; lps; lung; macrophages; mice; mouse; mrna; myeko; myeloid; necrosis; neutrophils; non; overexpression; patients; perivascular; points; post; protection; protein; pulmonary; recipient; recruitment; right; role; saline; severe; significant; solid; specific; states; syndrome; systemic; time; tnf; total; tristetraprolin; ttp; ttp ko; ttp myeko; united; wt mice cache: cord-282336-zvc04s39.txt plain text: cord-282336-zvc04s39.txt item: #75 of 105 id: cord-283427-fef9qsik author: Kim, Gwang-Ho title: Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines date: 2019-11-29 words: 3719 flesch: 50 summary: On the other hand, the permeability of EB dye in the C1 group was similar or higher than that in the LPS/EB group, meaning that BBB was damaged at vaccine concentration of C1 group. Consistent with results of previous studies, ZO-1 levels, but not occludin levels, were increased rapidly after 4 h of vaccine injection. keywords: assay; available; barrier; bbb; blood; brain; canine; concentration; control; diluted; diseases; dye; established; expression; fig; fold; group; higher; infectious; injection; junction; levels; live; lps; mice; module; mouse; mrna; occludin; pbs; permeability; porcine; positive; previous; rapid; reference; results; safety; solution; stock; study; tight; time; urgent; vaccine; zo-1 cache: cord-283427-fef9qsik.txt plain text: cord-283427-fef9qsik.txt item: #76 of 105 id: cord-285684-iiqyzqsb author: Li, Jin-ze title: Mechanically Stretched Mesenchymal Stem Cells Can Reduce the Effects of LPS-Induced Injury on the Pulmonary Microvascular Endothelium Barrier date: 2020-10-30 words: 4629 flesch: 43 summary: Biology and potential therapeutic value The hepatocyte growth factorexpressing character is required for mesenchymal stem cells to protect the lung injured by lipopolysaccharide in vivo MTOR/STAT-3 pathway mediates mesenchymal stem cell-secreted hepatocyte growth factor protective effects against lipopolysaccharideinduced vascular endothelial barrier dysfunction and apoptosis Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a 10 Stem Cells International randomised phase 2a safety trial Mesenchymal stem cells migration homing and tracking Characterization of key mechanisms in transmigration and invasion of mesenchymal stem cells Alveolar dynamics during mechanical ventilation in the healthy and injured lung The micromechanics of lung alveoli: structure and function of surfactant and tissue components Why the impact of mechanical stimuli on stem cells remains a challenge Ventilator Management Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Respiratory drive in the acute respiratory distress syndrome: pathophysiology, monitoring, and therapeutic interventions Surviving sepsis campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) Mechanical stimuli differentially control stem cell behavior: morphology, proliferation, and differentiation Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells Response of mesenchymal stem cells to the biomechanical environment of the endothelium on a flexible tubular silicone substrate Mechanical stimulation induces morphological and phenotypic changes in bone marrow-derived progenitor cells within a three-dimensional fibrin matrix Mechanical stress and the induction of lung fibrosis via the midkine signaling pathway Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac FIP200 is required for the cellautonomous maintenance of fetal hematopoietic stem cells Minimal criteria for defining multipotent mesenchymal stromal cells. Treatment with LPS can also alter the apoptotic status of endothelial barrier cells and badly damage the paracellular architecture of causing the endothelial barrier to function abnormally and producing pulmonary edema [43] . keywords: acute; apoptosis; ards; barrier; cadherin; cells; china; clinical; connexin-43; cultured; days; diego; distress; ecs; effects; endothelial; expression; figure; function; group; injured; injury; integrity; international; lps; lung; markers; mechanical; medium; mesenchymal; microvascular; minutes; morphology; mscs; paracellular; patients; permeability; pulmonary; research; respiratory; results; san; stem; stimulation; stretch; stretched; studies; study; surface; syndrome; system; therapeutic; therapy; tissue; treatment; untreated; upper; usa cache: cord-285684-iiqyzqsb.txt plain text: cord-285684-iiqyzqsb.txt item: #77 of 105 id: cord-292862-ezrkg0dc author: Myerson, Jacob W. title: Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment date: 2020-04-18 words: 14319 flesch: 42 summary: Our data thus indicate that NAP tropism for neutrophils in inflamed mouse lungs may be recapitulated in human lungs. 6, 10, 14, 18 Single cell suspensions prepared from mouse lungs were probed by flow cytometry to further characterize pulmonary neutrophils in naïve mice and in mice following LPS-induced inflammation. keywords: 400xg; accumulation; acute; administration; albumin; analysis; anesthetized; ansa; anti; antibody; ards; associated; azide; bacteria; bal; bare; bars; biodistributions; blood; buffer; catheter; cd45; cells; coli; composition; concentration; conjugation; contrast; control; cutoff; cytometry; data; dbco; dbco(20x)-igg; delivery; dextran; diameter; different; dose; drug; edema; effects; excess; exposure; facs; ferritin; figure; flow; fluid; fluorescent; fold; free; gfp; green; high; hours; human; human lungs; hydrophobic; igg; igg liposomes; images; imaging; induced; inflamed; inflamed lungs; inflammation; inflammatory; initial; injection; injured; injured lungs; injury; interactions; intravascular; kda; ketamine; ldng; leukocytes; levels; lipid; liposomes; lps; lps injury; lungs; ly6; lysozyme; marginated; marginated neutrophils; mice; minutes; model; mouse; nanogels; nanoparticles; nanostructures; naps; naïve; naïve lungs; naïve mice; nebulized; neutrophils; nhs; nps; organization; pbs; perfused; polystyrene; poni; positive; protein; pulmonary; reaction; regions; results; room; samples; sata; serum; signal; significant; single; size; solutions; specificity; spect; staining; structure; studies; study; supplementary; supplementary figure; supramolecular; surface; suspensions; table; targeting; temperature; tissue; treatment; tropism; types; uptake; vascular; vivo; xylazine cache: cord-292862-ezrkg0dc.txt plain text: cord-292862-ezrkg0dc.txt item: #78 of 105 id: cord-294193-xjq9j2gv author: Gamazo, Carlos title: Mimicking microbial strategies for the design of mucus-permeating nanoparticles for oral immunization date: 2015-01-20 words: 7501 flesch: 29 summary: Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins The hydrophobic barrier properties of gastrointestinal mucus The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system Membrane-bound mucin modular domains: from structure to function Composition and functional role of the mucus layers in the intestine Structural insights into bacterial recognition of intestinal mucins Barrier properties of mucus Mucins in the mucosal barrier to infection Mathematical modeling of molecular diffusion through mucus Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting Intestinal mucosal barrier function in health and disease Drug delivery: stealth particles give mucus the slip Characterization of particle translocation through mucin hydrogels Glycobiome: bacteria and mucus at the epithelial interface Glycosulfatase activity of Helicobacter pylori toward gastric mucin Helicobacter pylori moves through mucus by reducing mucin viscoelasticity Mucin biopolymers as broad-spectrum antiviral agents Evolutionary considerations in relating oligosaccharide diversity to biological function Chemotactic behavior of Campylobacter jejuni MUC1 cell surface mucin is a critical element of the mucosal barrier to infection Campylobacter jejuni motility and invasion of Caco-2 cells Mediation of Cryptosporidium parvum infection in vitro by mucin-like glycoproteins defined by a neutralizing monoclonal antibody Identification of a 148-kDa surface lectin from Giardia lamblia with specificity for alphamethyl-D-mannoside Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation Characterization of binding of Candida albicans to small intestinal mucin and its role in adherence to mucosal epithelial cells Intestinal mucins: the binding sites for Salmonella typhimurium Cloning, sequencing and distribution of the Salmonella typhimurium Lt2 sialidase gene, Nanh, provides evidence for interspecies gene transfer pylori decreases gastric mucin synthesis via inhibition of galactosyltransferase Cytosolic phospholipase A(2) activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis Early functional effects of Clostridium difficile toxin A on human colonocytes Interaction of cholera-toxin with cloned human goblet cells in monolayer culture Activation of mucin exocytosis and upregulation of MUC genes in polarized human intestinal mucin-secreting cells by the thiol-activated exotoxin listeriolysin O Role of intestinal mucins in innate host defense mechanisms against pathogens Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? Glycosidases in mucin-dwelling protozoans Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease Entamoeba histallytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel Inhibition of gastric mucin synthesis by Helicobacter pylori TagA is a secreted protease of Vibrio cholerae that specifically cleaves mucin glycoproteins Mucin degradation mechanisms by distinct Pseudomonas aeruginosa isolates in vitro EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin A glycosyl hydrolase activity of mammalian reovirus sigma 1 protein can contribute to viral infection through a mucus layer Mucin-related epitopes distinguish M cells and enterocytes in rabbit appendix and Peyer's patches Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function The control of adaptive immune responses by the innate immune system Effector triggered immunity: activation of innate immunity in metazoans by bacterial effectors The membranous epithelial (M) cell and the mucosal immune system Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response M cells expressing the complement C5a receptor are efficient targets for mucosal vaccine delivery Cutting edge: Brucella abortus exploits a cellular prion protein on intestinal M cells as an invasive receptor Biocontainment laboratory risk assessment: perspectives and considerations Liposomes and ISCOMs Nanotechnology in vaccine delivery Oral delivery of nanoparticle-based vaccines Synthetic particulate antigen delivery systems for vaccination Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination Poly(anhydride) nanoparticles act as active Th1 adjuvants through Toll-like receptor exploitation Immunity in response to particulate antigen-delivery systems Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers The role of flagella, but not fimbriae, in the adherence of Salmonella enterica serotype Enteritidis to chick gut explant Identification of Salmonella Enteritidis outer membrane proteins expressed during attachment to human intestinal epithelial cells Gantrez Ò AN nanoparticles as an adjuvant for oral immunotherapy with allergens Innate immune recognition Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants Adjuvants modulating mucosal immune responses or directing systemic responses towards the mucosa Different responses of macrophages to smooth and rough Brucella spp.: In immune cells (i.e. DCs and macrophages), the MR mediate endocytosis, function as antigen capture receptors and are involved in antigen capture and presentation keywords: acid; addition; adequate; adjuvant; agglutinin; allergens; antigen; approach; bacteria; barrier; binding; biological; capability; capable; cells; cellular; chemical; coated; compounds; consequence; delivery; different; domains; enteric; enzymes; epithelium; examples; fact; fig; flagellin; gastrointestinal; glycocalyx; glycoconjugates; glycoproteins; gut; high; host; human; hydrophobic; immune; immune response; immunity; immunization; immunotherapy; important; infection; innate; interactions; intestinal; layer; lectin; levels; ligands; like; lipid; liposomes; lps; mannose; mechanisms; membrane; mice; microbial; microorganisms; model; molecules; mucin; mucosal; mucus; mucus layer; nanocarriers; nanoparticles; oral; order; outer; particulates; pathogens; physical; presence; production; products; properties; protective; purpose; pylori; receptors; related; response; salmonella; secretion; similar; small; specific; strategies; structure; surface; synthesis; system; systemic; target; targeting; tlr; tract; use; vaccination; vaccine; view; virus; vivo cache: cord-294193-xjq9j2gv.txt plain text: cord-294193-xjq9j2gv.txt item: #79 of 105 id: cord-296258-8pc2p3az author: Hwang, Eun-Ha title: Toll/IL-1 domain-containing adaptor inducing IFN-β (TRIF) mediates innate immune responses in murine peritoneal mesothelial cells through TLR3 and TLR4 stimulation date: 2016-01-31 words: 5605 flesch: 46 summary: Mesothelial cells are a sentinel for inflammatory response of the mesothelium caused by bacterial products or infection, however, the precise mechanism by which mesothelial cells trigger innate immune responses against microbial infection still remains to be elucidated. Although mesothelial cells are known to express multiple Toll-like receptors (TLRs) which contribute to trigger innate immune responses against infections, the precise molecular mechanism remains still unclear. keywords: activation; adaptor; aeruginosa; bacterial; ccl2; cells; chemokines; coli; concentration; cxcl1; cytokines; deficient; deficient pmcs; dependent; expression; fig; forward; gene; human; ifn; il-1; il-6; immune; impaired; infection; inflammatory; innate; inos; like; lps; macrophages; manner; mapks; mesothelial; mice; min; mouse; murine; myd88; nitric; nitrite; oxide; pathway; peritoneal; peritonitis; pmcs; poly; production; receptor; response; reverse; role; signaling; stimulation; study; synthesis; time; tlr3; tlr4; toll; trif; type cache: cord-296258-8pc2p3az.txt plain text: cord-296258-8pc2p3az.txt item: #80 of 105 id: cord-297128-s5c9h4lm author: Hong, Joung-Woo title: Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models date: 2012-11-28 words: 3863 flesch: 47 summary: In vivo LPS injection CWE (20, 100 or 500 mg/kg of body weight) was given to mice via oral gavage for 6 days. Twenty microliters of each fraction or total CWE in 1.58 ml of water was incubated with 100 μl of FC reagent (Sigma) for 5 min at room temperature. keywords: activation; activities; activity; anti; bark; cells; cinnamon; compounds; control; cwe; degradation; dose; effect; erk1/2; expression; extract; figure; fraction; high; hour; il-6; induced; inflammatory; inhibitory; insulin; iκbα; jnk; kda; kinase; levels; lps; macrophages; map; mice; min; molecular; oral; p38; pathways; peritoneal; phospho; phosphorylation; polyphenols; response; results; rich; serum; sigma; signaling; stimulated; stimulation; study; tnf; total; tumor; usa; vivo; water cache: cord-297128-s5c9h4lm.txt plain text: cord-297128-s5c9h4lm.txt item: #81 of 105 id: cord-298224-flyx85lr author: Hibbitts, Alan J. title: In Vitro and In Vivo Assessment of PEGylated PEI for Anti-IL-8/CxCL-1 siRNA Delivery to the Lungs date: 2020-06-27 words: 11359 flesch: 48 summary: Furthermore, PEI anti-CXCL-1 siRNA nanoparticles were also found to demonstrate reduced gene expression compared to their non-targeting controls although this was not found to be significant due to the variability in the NT-siRNA-treated animals. Twin-stage impinger cell studies highlighted the significantly enhanced ability of PEI-PEG siRNA nanoparticles to be nebulised, traverse the mucus lining of airway epithelial cells and reduce gene and protein expression compared to PEI siRNA nanoparticles. keywords: acute; addition; administration; aerogen; air; airway; analysis; animals; anti; apical; bal; basal; calu-3; case; cells; changes; clinical; collected; controls; cxcl-1; cxcl-1 sirna; cytokine; data; decrease; delivery; development; device; differences; doses; droplets; drug; effect; efficiency; epithelial; experiments; expression; figure; fluid; fpf; fraction; gapdh; gapdh sirna; gene; genetic; groups; higher; il-8; il-8 sirna; il8 sirna; immune; inflammation; inflammatory; inhibition; insert; ireland; kda; knockdown; levels; liquid; lower; lpeg anti; lpeg sirna; lps; lung; macrophages; mesh; min; model; monolayers; mucus; nebulisation; nebulised; nebulised sirna; non; output; overall; pbs; pegylated; pei; pei anti; performance; polymer; post; previous; prior; protein; pulmonary; rats; respiratory; samples; secretion; sections; sequence; significant; significant changes; sirna; sirna delivery; sirna nanoparticles; size; solution; stage; studies; study; successful; surface; system; targeting; teer; tension; time; transfection; transwell; treatment; tsi; vivo; work cache: cord-298224-flyx85lr.txt plain text: cord-298224-flyx85lr.txt item: #82 of 105 id: cord-298646-wurzy88k author: van der Merwe, René title: Challenge models to assess new therapies in chronic obstructive pulmonary disease date: 2012-09-13 words: 4781 flesch: 34 summary: No effect of inhaled budesonide on the response to inhaled ozone in normal subjects Effects of cyclo-oxygenase inhibition on ozone-induced respiratory inflammation and lung function changes SCH527123, a novel treatment option for severe neutrophilic asthma SB-656933, a novel CXCR2 selective antagonist, inhibits ex-vivo neutrophil activation and ozone-induced airway inflammation in humans Short-term respiratory effects of 0.12 ppm ozone exposure in volunteers with chronic obstructive pulmonary disease The acute effects of 0.2 ppm ozone in patients with chronic obstructive pulmonary disease Response to ozone in volunteers with chronic obstructive pulmonary disease Responses of older men with and without chronic obstructive pulmonary disease to prolonged ozone exposure Detection of rhinovirus RNA in lower airway cells during experimentally induced infection The major human rhinovirus receptor is ICAM-1 Members of the low density lipoprotein receptor family mediate cell entry of a minor-group common cold virus Role of p38 mitogen-activated protein kinase in rhinovirus-induced cytokine production by bronchial epithelial cells Rhinovirus induction of the CXC chemokine epithelial-neutrophil activating peptide-78 in bronchial epithelium Low grade rhinovirus infection induces a prolonged release of IL-8 in pulmonary epithelium Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues Rhinoviruses infect the lower airways Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations A 1-year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of COPD Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease A one-year prospective study of infectious etiology in patients hospitalized with acute exacerbations of COPD and concomitant pneumonia Rhinovirus infections in chronic bronchitis: isolation of eight possibly new rhinovirus serotypes Role of infection in chronic bronchitis Infectious agents associated with exacerbations of chronic obstructive bronchopneumopathies and asthma attacks Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Respiratory viral infections in adults with and without chronic obstructive pulmonary disease An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study An experimental model of virus induced chronic obstructive pulmonary disease exacerbation Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation Comparative antirhinoviral activities of soluble intercellular adhesion molecule-1 (sICAM-1) and chimeric ICAM-1/immunoglobulin A molecule Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trial Genetic clustering of all 102 human rhinovirus prototype strains: serotype 87 is close to human enterovirus 70 Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 for Pleconaril Respiratory Infection Study Group. The Global Initiative for Chronic Obstructive Lung Disease defines chronic obstructive pulmonary disease (COPD) as a … common preventable and treatable disease characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. keywords: activation; acute; agents; airway; asthma; cells; challenge; chronic; clinical; copd; corticosteroids; data; development; disease; dose; drug; early; effects; efficacy; endotoxin; exacerbations; experimental; exposure; fev; fluticasone; function; healthy; hours; hrv; human; il-6; il-8; increase; induced; infection; inflammation; inflammatory; inhaled; levels; lower; lps; lung; making; model; monocytes; neutrophils; new; novel; obstructive; oral; ozone; patients; placebo; potential; pulmonary; receptor; reduction; respiratory; response; rhinovirus; role; significant; sputum; studies; study; subjects; symptoms; systemic; therapeutic; therapies; treatment; viral; volunteers cache: cord-298646-wurzy88k.txt plain text: cord-298646-wurzy88k.txt item: #83 of 105 id: cord-300912-w85t4zz6 author: Wu, Beibei title: n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils date: 2017-10-25 words: 3705 flesch: 41 summary: Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2 Sepsis biomarkers Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome Evaluation of Toll-like, chemokine, and integrin receptors on monocytes and neutrophils from peripheral blood of septic patients and their correlation with clinical outcomes Inflection points in sepsis biology: From local defense to systemic organ injury Blockade of CXCR2 signalling: A potential therapeutic target for preventing neutrophil-mediated inflammatory diseases Neutrophils in innate and adaptive immunity Activation of AMPK enhances neutrophil chemotaxis and bacterial killing -hydroxy-3-metho xyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis Prospective study of neutrophil chemokine responses in trauma patients at risk for pneumonia Down-regulation of CXCR1 and CXCR2 expression on human neutrophils upon activation of whole blood by S. aureus is mediated by TNF-alpha Toll-like receptor 4 signaling on dendritic cells suppresses polymorphonuclear leukocyte CXCR2 expression and trafficking via interleukin 10 during intra-abdominal sepsis Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2 IL-8 in septic shock, endotoxemia, and after IL-1 administration Antiviral activity of Folium isatidis derived extracts in vitro and in vivo Antiviral activity of the effective monomers from Folium Isatidis against influenza virus in vivo Antiviral effect of Folium Isatidis on herpes simplex virus type I Using herbal medi-WM: Using herbal medi-: Using herbal medicine as a means of prevention experience during the SARS crisis Antibacterial properties of Chinese herbal medicines against nosocomial antibiotic resistant strains of Pseudomonas aeruginosa in Taiwan LC-APCI-MS method for detection and analysis of tryptanthrin, indigo and indirubin in daqingye and banlangen n-Butanol extract from Folium isatidis inhibits lipopolysaccharide-induced inflammatory cytokine production in macrophages and protects mice against lipopolysaccharide-induced endotoxic shock CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism Cecal ligation and puncture-induced murine sepsis does not cause lung injury International study of the prevalence and outcomes of infection in intensive care units Neutrophils in sepsis: Battle of the bands Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice Targeting neutrophils in sepsis Early Goal-Directed Therapy Collaborative Group: The extract increased the gene expression levels of CXCR1, CXCR2 and CD62L in a dose-dependent manner. IL-8, as the ligand of CXCR1 and CXCR2, is important in the regulation of neutrophil migration. keywords: activity; addition; analysis; anti; blood; butanol; butanol extract; cat; cd62l; cells; chemokine; chemotaxis; cxcr2; dependent; dose; downregulation; effect; expression; extract; fig; fisher; folium; following; human; il-8; inc; inflammatory; isatidis; isolated; levels; lps; manner; migration; mortality; neutrophils; patients; pmns; present; previous; receptors; scientific; sepsis; septic; stimulation; study; thermo; tlr4; treatment cache: cord-300912-w85t4zz6.txt plain text: cord-300912-w85t4zz6.txt item: #84 of 105 id: cord-302295-nblmshni author: Savva, Athina title: Targeting Toll-Like Receptors: Promising Therapeutic Strategies for the Management of Sepsis-Associated Pathology and Infectious Diseases date: 2013-11-18 words: 10341 flesch: 30 summary: Prophylactic administration of anti-TLR4 antibodies blunted TNF production and strikingly increased survival in E. coli sepsis, from 0% in the control antibody group to 80% in the anti-TLR4 group. Our studies demonstrate that anti-TLR4 antibodies are efficient as adjunctive therapy for E. coli sepsis, with a window of clinical application comprising prophylactic and therapeutic intervention opportunities. keywords: activation; activity; acute; adaptive; administration; adverse; agonist; antagonist; anti; antibodies; antibody; bacterial; binding; cells; challenge; chloroquine; chronic; clinical; coli; complex; cpg; cpg10101; cytokine; data; dendritic; dependent; development; diseases; dna; domain; dose; double; drug; effect; efficacy; endotoxin; eritoran; events; experimental; expression; failure; flagellin; gene; gram; group; hcv; healthy; hepatitis; high; hiv; host; human; ifn; ifnα; immune; immunity; immunology; induction; infected; infection; inflammatory; influenza; inhibited; inhibition; injury; innate; intracellular; lethal; levels; ligands; like; like receptor; lps; md-2; mice; microbial; model; molecule; monoclonal; mortality; mouse; myd88; negative; new; non; opn-305; oral; pathways; patients; pharmacokinetics; phase; placebo; plasmacytoid; poly(i; production; promising; protein; prrs; randomized; receptor; recognition; respiratory; response; results; rna; role; safety; sensing; sepsis; septic; severe; shock; signaling; single; strategies; studies; study; surface; survival; tak-242; therapeutic; therapy; tlr1; tlr2; tlr3; tlr4; tlr5; tlr7; tlr7/8; tlr8; tlr9; tlrs; toll; treatment; trial; trif; type; usa; viral; virus; viruses; volunteers cache: cord-302295-nblmshni.txt plain text: cord-302295-nblmshni.txt item: #85 of 105 id: cord-302490-em1tiz7s author: Cañadas, Olga title: Lipid–Protein and Protein–Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis date: 2020-05-25 words: 16704 flesch: 27 summary: Front Surfactant protein A binds Mycoplasma pneumoniae with high affinity and attenuates its growth by recognition of disaturated phosphatidylglycerols Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria respiratory fungal infections: Their role in the inflammatory response Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins Collectins and fungal pathogens: Roles of surfactant proteins and mannose binding lectin in host resistance Surfactant protein D binding to terminal alpha1-3-linked fucose residues and to Schistosoma mansoni Opsonic activities of surfactant proteins A and D in phagocytosis of gram-negative bacteria by alveolar macrophages Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A Purification of a cell-surface receptor for surfactant protein A Lung surfactant proteins (SP-A and SP-D) in non-adaptive host responses to infection Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner Collectin surfactant protein D binds antibodies and interlinks innate and adaptive immune systems By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation Natural Anti-Infective Pulmonary Proteins: In Vivo Cooperative Action of Surfactant Protein SP-A and the Lung Antimicrobial Peptide SP-BN Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages Pulmonary collectins enhance phagocytosis of Mycobacterium avium through increased activity of mannose receptor Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A Ten Haken, B.; et al. A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity Interactions of surfactant protein A with influenza A viruses: Binding and neutralization Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses Mechanisms of anti-influenza activity of surfactant proteins A and D: Comparison with serum collectins Collectin-mediated antiviral host defense of the lung: keywords: abca3; absence; accumulation; acid; activation; activity; acute; acyl; adsorption; ae2c; aggregates; air; alteration; alveolar; anionic; antimicrobial; apoptosis; apoptotic; associated; bacterial; binding; binds; bodies; calcium; cd14; cells; cholesterol; chronic; clearance; collectins; complex; components; core; defense; deficiency; dependent; different; direct; disease; distress; domain; dppc; dynamics; effect; endoplasmic; epithelial; essential; expression; extracellular; factor; fibrosis; figure; film; fluid; formation; forms; function; gene; genetic; gpr116; gram; growth; hand; homeostasis; host; human; hydrophobic; immune; immunity; important; increase; induced; infection; inflammation; inflammatory; influenza; inhibition; inhibits; injury; innate; interaction; interface; interfacial; key; lamellar; lbp; lbs; levels; like; lipid; lipopolysaccharide; liquid; lps; lung; lung surfactant; macrophages; material; md2; mechanical; mechanism; membrane; metabolism; mice; microorganisms; model; moiety; molecular; molecules; mutations; myelin; negative; nets; non; pathogens; pathway; permeability; phagocytosis; phosphate; phospholipids; plasma; pneumoniae; pool; potential; presence; process; proper; properties; protein; protein d; protein sp; pulmonary; pulmonary surfactant; receptor; recognition; reduced; regard; region; regulates; regulation; remodeling; repair; residues; respiratory; response; reticulum; role; rough; secretion; signaling; size; small; smooth; spaces; specific; stability; structure; subsequent; surface; surfactant; surfactant homeostasis; surfactant lipids; surfactant protein; susceptibility; syncytial; syndrome; synthesis; system; terminal; tissue; tlr4; transfer; tubular; type; uptake; vesicles; viral; virus; vivo cache: cord-302490-em1tiz7s.txt plain text: cord-302490-em1tiz7s.txt item: #86 of 105 id: cord-306577-gq6fss5l author: Hsueh, Wei title: Neonatal Necrotizing Enterocolitis: Clinical Considerations and Pathogenetic Concepts date: 2002-11-11 words: 8425 flesch: 37 summary: Intestinal PAF concentrations were elevated (270 Ϯ 80 pg/g) in animals stressed with asphyxia, formula feeding, and bacterial inoculation compared with age-matched, healthy, maternally fed controls (70 Ϯ 50 pg/g, P Ͻ 0.05). Injection of PAF induces intestinal necrosis, and PAF antagonists prevent the bowel injury induced by bacterial endotoxin, hypoxia, or challenge with tumor necrosis factor-a (TNF) plus endotoxin in adult rats. keywords: acetylhydrolase; action; activation; activity; adhesion; animals; antagonists; asphyxia; bacterial; birth; blood; bowel; bowel injury; bowel necrosis; cases; cause; cells; challenge; circulation; clinical; complement; controls; development; disease; doses; effect; endogenous; endothelial; endotoxin; enterocolitis; enzyme; epithelial; experimental; expression; factor; feeding; fig; formula; group; higher; human; hypoxia; ileum; incidence; increase; induced; infants; inflammation; inflammatory; injection; injury; intestinal; intestinal injury; ischemic; leukocyte; levels; life; low; lps; mechanisms; mesenteric; mice; milk; min; model; mrna; mucosal; nec; necrosis; necrosis factor; necrotizing; neonatal; newborn; nitric; normal; oxide; oxygen; paf; pathogenesis; patients; permeability; plasma; platelet; pmn; production; protective; rat; rats; receptor; regulation; role; severe; shock; small; study; table; tissue; tnf; tumor; vascular; vasoconstriction; vivo; web; weight; xanthine cache: cord-306577-gq6fss5l.txt plain text: cord-306577-gq6fss5l.txt item: #87 of 105 id: cord-310535-ay2cdf2w author: Cho, Chang-Won title: Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages date: 2017-06-20 words: 4643 flesch: 38 summary: The effects of HMFO on the expression of inflammatory proteins such as COX-2 and iNOS in cytosolic extracts from the colon of colitis mice were detected by Western blot analysis. It has many potentially beneficial effects such as antitumor, antioxidant, and anti-inflammatory effects; guards against diabetes mellitus, gastric disorders, neuronal damage, and hypercholesterolemia; and causes vascular relaxation effects keywords: activation; activity; acute; analysis; anti; bowel; cells; chronic; colitis; colon; colonic; control; cox-2; crypts; cynanchum; cytokines; dai; damage; dextran; disease; dss; effects; experimental; expression; factor; figure; group; high; histological; hmfo; ibd; il-6; immune; induced; inducible; infiltration; inflammation; inflammatory; inos; levels; loss; lps; macrophages; medicine; mice; molecular; mpo; mucosal; nitric; normal; nuclear; oxide; patients; pge; polysaccharides; production; protein; raw; results; score; serum; sodium; stool; study; system; tissue; tnf; treatment; ulcerative; weight; wilfordii cache: cord-310535-ay2cdf2w.txt plain text: cord-310535-ay2cdf2w.txt item: #88 of 105 id: cord-311481-2awvmpyh author: Kosukegawa, Ima title: The proton pump inhibitor, lansoprazole, prevents the development of non-traumatic osteonecrosis of the femoral head: an experimental and prospective clinical trial date: 2020-01-14 words: 4748 flesch: 49 summary: The present study could not determine whether the disappearance of ONFH was due to its natural course or the effects of LPZ, and ONFH patients need to be observed in a future clinical study. LPZ treatment significantly suppressed the activity of NF-κB in the LPS + LPZ + MPSL group compared to that in the LPS + MPSL group at 1 day after the last injection ( Fig. 1 : LPS + MPSL vs. LPS + LPZ + MPSL, 100 ± 3.6 vs. 80.5 ± 5.6; p = 0.03). keywords: activity; clinical; control; corticosteroid; corticosteroid treatment; day; days; development; disease; dosage; effective; experimental; factor; femoral; fig; groups; head; images; imiquimod; immune; inhibitor; injection; irf7; japan; lansoprazole; lesion; lps; lpz; mean; months; mpsl; mpsl group; mpsl rats; n =; onfh; osteonecrosis; patients; prednisolone; present; prevention; rats; results; sapporo; study; suppression; test; treatment; trial; type; underlying; weeks cache: cord-311481-2awvmpyh.txt plain text: cord-311481-2awvmpyh.txt item: #89 of 105 id: cord-322729-47c9z2gk author: Wu, Chieh-Shan title: Antihelminthic niclosamide modulates dendritic cells activation and function date: 2014-04-30 words: 6110 flesch: 42 summary: Dendritic cells and the maintenance of self-tolerance Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis Impact of valproic acid on dendritic cells function Impact of HDAC inhibitors on dendritic cell functions The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function Gold sodium thiomalate suppresses the differentiation and function of human dendritic cells from peripheral blood monocytes Corticosterone impairs dendritic cell maturation and function Innovating by developing new uses of already-approved drugs: trends in the marketing approval of supplemental indications Evaluation of oncology drugs at the European Medicines Agency and US Food and Drug Administration: when differences have an impact on clinical practice Worm cure without tears. World Health Organisation Pharmacokinetics of anti-SARS-CoV agent niclosamide and its analogs in rats Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation Niclosamide therapy for tapeworm infections Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects Dendritic cells-at the front-line of pathogen attack Type I interferon is selectively required by dendritic cells for immune rejection of tumors This study was supported by grants from the VGHKS -101-061, 102-053 and Ministry of Education, Taiwan under the ATU plan Chieh-Shan Wu, Yi-Rong Li and Jeremy J. W. Chen contributed equally to this work. keywords: ability; activation; activity; addition; administration; alpha; anti; antigen; assay; bmdcs; bone; c57bl/6; cd4; cd8; cells; control; costimulatory; cytokines; data; dcs; dendritic; dextran; different; diseases; dmso; dnfb; drug; ear; effect; erk; experiments; expression; fig; fitc; flow; function; gamma; ifn; immature; immune; induced; inflammatory; inhibits; jnk; lps; mapk; marrow; maturation; mhc; mice; molecules; mouse; niclosamide; ova; ovap; p38; pathway; presence; production; proliferation; receptor; responses; results; role; signaling; significant; specific; stimulated; stimulation; study; target; tlr; tnf; treatment; usa cache: cord-322729-47c9z2gk.txt plain text: cord-322729-47c9z2gk.txt item: #90 of 105 id: cord-329274-ncvvmkca author: Labarque, G title: Porcine reproductive–respiratory syndrome virus infection predisposes pigs for respiratory signs upon exposure to bacterial lipopolysaccharide date: 2002-08-02 words: 3329 flesch: 46 summary: Two out of the 15 pigs did not show respiratory signs after LPS administration. After LPS administration, pigs were intensively monitored for clinical signs. keywords: administration; alveolar; bacterial; bal; broncho; cell; clinical; days; disease; experiment; exposure; fever; fluids; general; infected; infection; inoculated; lps; lungs; mean; negative; non; pigs; porcine; prrsv; reeth; reproductive; respiratory; scores; second; signs; similar; study; syndrome; table; van; virological; virus cache: cord-329274-ncvvmkca.txt plain text: cord-329274-ncvvmkca.txt item: #91 of 105 id: cord-331887-kagggou1 author: liu, Chang title: An integrated network pharmacology and RNA-Seq approach for exploring the preventive effect of Lonicerae japonicae flos on LPS-induced acute lung injury date: 2020-09-09 words: 3202 flesch: 46 summary: AIM OF THE STUDY: In this study, we examined the main active ingredients in LJF and the protective effects of LJF on LPS-induced ALI in rats. First, the main active ingredients of LJF were screened in the TCMSP database, and the ALI-associated targets were collected from the GeneCards database. keywords: acid; active; acute; ali; analysis; compound; ctrl; cxcl1; degree; degs; dxsm; expression; genes; groups; ifng; il-17; il17a; il6; induced; inflammatory; ingredients; injury; involved; levels; ljf; lps; lung; main; mmp9; network; nfkbia; p<0.05; pathway; pcr; pharmacology; potential; qrt; related; results; rna; seq; study; table; targets; tissue; tnfaip3; treatment cache: cord-331887-kagggou1.txt plain text: cord-331887-kagggou1.txt item: #92 of 105 id: cord-335107-ew9uid2e author: He, Xinran title: Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice date: 2020-09-23 words: 4510 flesch: 48 summary: The results showed that DPP-4 inhibition has no effect on incident rate of diabetes and metabolic parameters in NOD mice. Long-term inhibition of DPP-4 reduced CD4+T cells to infiltrate into islets and ameliorated insulitis in NOD mice. keywords: administration; blood; cd4+t; cells; control; control group; coronavirus; covid-19; cytokines; diabetes; diabetic; dipeptidyl; disease; effect; expression; fig; glucose; group; ifn; il-12; il-6; immune; immunity; infection; infiltration; inflammatory; inhibition; inhibitors; innate; insulitis; intake; islets; levels; long; lps; lps group; mice; mononuclear; nod; nod mice; patients; present; serum; sitagliptin; sitagliptin group; study; term; tnf; treatment; type; wuhan cache: cord-335107-ew9uid2e.txt plain text: cord-335107-ew9uid2e.txt item: #93 of 105 id: cord-336432-tu00gffr author: Wang, Zhiyu title: Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide date: 2020-07-07 words: 6618 flesch: 40 summary: We investigated if furosemide inhibits the production of pro-inflammatory cytokines (M1) or promotes the secretion of anti-inflammatory cytokines (M2) using various macrophage cell lines including RAW264.7, THP-1 and SIM-A9. In this study, a library of small molecules endogenous to the human body was assembled, subjected to in silico molecular docking simulations and a focused in vitro screen to identify anti-pro-inflammatory activity via interleukin inhibition. keywords: acid; activation; active; activity; amino; analysis; anti; assay; binding; broad; bumetanide; candidate; cells; clinical; concentration; conformer; covid-19; crystallized; cytokines; data; disease; docking; drug; endogenous; energy; et al; expression; fig; furosemide; haa; hospital; human; ifnγ; il-1β; il-6; il-8; induced; infection; inflammation; inflammatory; inflammatory cytokines; inhaled; innate; ligand; lps; macrophage; markers; mechanism; medium; minimum; molecular; molecule; multiple; pathway; patients; pdb; polarization; pose; pro; production; properties; protein; raw264.7; release; residues; response; results; sars; score; screen; silico; simulations; site; small; step; structure; study; therapeutic; thp-1; tlr4; tnf; tocilizumab; treatment; viral; vitro cache: cord-336432-tu00gffr.txt plain text: cord-336432-tu00gffr.txt item: #94 of 105 id: cord-337923-1vbkttzx author: Li, Xiao-Jun title: Chemical Constituents and an Antineuroinflammatory Lignan, Savinin from the Roots of Acanthopanax henryi date: 2019-02-21 words: 4003 flesch: 46 summary: BV2 cells were pretreated with the compounds for 3 h and stimulated with LPS (1 g/mL) for 24 h. The concentration required to inhibit the production of NO by 50% (IC 50 value) was calculated based on the concentrations of NO and PGE 2 released into the culture Figure 2 : The effect of compound on LPS-induced iNOS and COX-2 protein expression in BV2 microglial cells. BV2 cells were pretreated with compound for 3 h and stimulated with LPS (1 g/mL) for 24 h. As a result, LPS augmented the expression of iNOS and COX-2 proteins; however, pretreatment with compound reversed these responses (Figure 2 ). keywords: acanthopanax; acid; activities; activity; analysis; anti; antineuroinflammatory; bv2; bv2 cells; caffeoyl; cells; chemical; compound; constituents; cox-2; data; diseases; effects; erk; etoac; expression; gel; henryi; il-1; il-6; inhibition; inhibitory; inos; isolated; jnk; korea; leaves; lps; mapk; microglial; neuroinflammation; nmr; p38; pge; phosphorylation; previous; production; proinflammatory; protein; quinic; responses; roots; savinin; silica; spectral; tnf-; usa cache: cord-337923-1vbkttzx.txt plain text: cord-337923-1vbkttzx.txt item: #95 of 105 id: cord-339272-trd6rkxw author: Chen, Na title: Prime-O-glucosylcimifugin attenuates lipopolysaccharide-induced acute lung injury in mice date: 2013-04-24 words: 4323 flesch: 40 summary: Seven hours after LPS administration, the BALF was collected to evaluate the total cell counts and the number of inflammatory cells in BALF, such as macrophages and neutrophils. In the LPS group, the lungs were significantly damaged with inflammatory cell infiltration, alveolar wall thickening and interstitial edema. keywords: activation; activity; acute; administration; ali; alveolar; anti; balf; cells; changes; china; concentrations; control; cytokines; effect; elisa; expression; factor; fig; glucosylcimifugin; group; il-1β; il-6; induced; inflammation; inflammatory; injury; jnk; levels; lipopolysaccharide; lps; lung; lung injury; macrophages; mapk; mice; mouse; mpo; neutrophils; p38; phosphorylation; prime; pro; production; protein; pulmonary; raw; release; respiratory; responses; results; severe; stimulation; study; syndrome; tnf; usa; weight cache: cord-339272-trd6rkxw.txt plain text: cord-339272-trd6rkxw.txt item: #96 of 105 id: cord-341458-hkopopa6 author: Dormont, Flavio title: Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents date: 2020-06-05 words: 7113 flesch: 40 summary: The real-time in vivo imaging showed that, in comparison with the control healthy left paw, a strong increase in the radiant efficiency of the inflamed right paw could be detected after intravenous injection of fluorescent SQAd/ VitE NPs (Fig. 2 , A to E). Accordingly, our results showed that VitE was efficiently encapsulated in SQAd NPs to form stable multidrug NPs. keywords: accumulation; activation; acute; adenosine; aldrich; animals; anova; antioxidant; blood; cells; challenge; comparison; concentration; control; cytokines; data; detection; dose; drugs; effects; efficacy; endotoxemia; experiments; fig; fluorescent; free; hours; imaging; increase; inflamed; inflammation; inflammatory; injection; injury; intracellular; intravenous; lethal; levels; lipid; lps; lungs; macrophages; manner; mda; mean; measurements; medium; mice; min; model; multidrug; multiple; nanoparticles; nitric; nps; observed; organ; oxidative; oxide; paw; phase; plasma; potential; pressure; pro; production; raw; receptors; response; results; ros; sepsis; sigma; signaling; significant; sites; solution; sqad; squalene; stimulation; stress; studies; systemic; targeted; test; therapeutic; time; tissue; tnf-; treatment; uncontrolled; vite; vite nps; vivo; waters; way cache: cord-341458-hkopopa6.txt plain text: cord-341458-hkopopa6.txt item: #97 of 105 id: cord-342001-41vjh3mq author: Selwyn, David title: A prospective multicentre external validation study of the Liverpool Peritonsillar abscess Score (LPS) with a no‐examination COVID‐19 modification date: 2020-10-20 words: 2191 flesch: 46 summary: key: cord-342001-41vjh3mq authors: Selwyn, David; Yang, Ding; Heward, Elliot; Kerai, Ashwin; Thompson, Elinor; Shommakhi, Abulgasem; Faulkner, Scott; Siau, Richard; Walijee, Hussein; Hampton, Tom; Chudek, Dorota; Singhera, Supriya; Din, Waqas; Lau, Andrew S. title: A prospective multicentre external validation study of the Liverpool Peritonsillar abscess Score (LPS) with a no‐examination COVID‐19 modification date: 2020-10-20 journal: Clin Otolaryngol DOI: 10.1111/coa.13652 sha: doc_id: 342001 cord_uid: 41vjh3mq OBJECTIVES: Our primary aim was to validate the Liverpool Peritonsillar abscess Score (LPS) externally in a new patient cohort. keywords: abscess; aim; covid-19; data; diagnosis; examination; external; high; liverpool; lps; model; negative; non; npv; observational; oral; pandemic; patients; peritonsillar; predictive; prospective; pta; sample; score; secondary; sensitivity; size; study; throat; tonsillitis; use; validation; value cache: cord-342001-41vjh3mq.txt plain text: cord-342001-41vjh3mq.txt item: #98 of 105 id: cord-346488-y7r7el4e author: Prantner, Daniel title: The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection date: 2017-07-20 words: 6760 flesch: 44 summary: Mouse mAb were used to visualize TLR4 proteins with the tags FLAG (M2 clone) (Sigma-Aldrich) and eCFP (clone OTI8A6) (OriGene Technologies, Rockville, MD, USA) by Western blot analysis. In addition to the mortality and morbidity associated with the viral infection, coinfections can exacerbate the outcome of influenza infection, as exemplified by the 1918 pandemic, in which most deaths were due to secondary bacterial pneumonia keywords: absence; activation; activity; antagonist; assay; bacterial; beads; binding; biotinylated; cells; clinical; cytokine; damps; data; defensins; dependent; dose; effect; eritoran; expression; fig; flag; gene; glycosylation; hmgb1; human; ifn; il-1b; immune; induction; infection; inflammation; influenza; inhibition; innate; interaction; irak4; lal; like; lps; lung; membrane; mfs; mice; min; model; mouse; mrna; myd88; novel; pathways; peptide; pr8; presence; proinflammatory; protein; rc-101; rcs; receptor; recognition; response; rig; rna; role; seasonal; secretion; sequestration; signaling; similar; specific; strains; study; synthesis; system; time; tlr2; tlr4; tnf; toll; transduction; treatment; trif; usa; viral; virus; vitro; vivo cache: cord-346488-y7r7el4e.txt plain text: cord-346488-y7r7el4e.txt item: #99 of 105 id: cord-348391-xytmq2f2 author: Wyganowska-Swiatkowska, Marzena title: Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review date: 2020-06-30 words: 8109 flesch: 34 summary: All of the identified herbal extracts and flavonoids exert suppression of HMGB1 activity. All of the identified herbal extracts and flavonoids exert suppression of HMGB1 activity. keywords: ability; ace2; acid; activation; active; activities; activity; acute; adhesion; angiotensin; anti; antiviral; attachment; baicalein; binding; box; cell; cellular; chemical; clinical; compounds; converting; coronavirus; cov-2; covid-19; cytokines; data; decreases; direct; effect; effective; egcg; entry; enzyme; experimental; expression; extracellular; extract; flavonoids; function; ginsenoside; green; group; hepatitis; herbal; high; hmgb1; host; human; ifn; il-1β; il-6; immune; induced; infection; inflammation; inflammatory; influenza; inhibited; inhibition; inhibits; injury; late; lethal; levels; like; lipid; lps; lung; macrophages; main; mediator; mice; migration; mobility; model; molecules; monocytes; mortality; multiple; murine; novel; nuclear; nucleus; phenolic; polysaccharide; production; protease; protein; quercetin; receptor; reduced; release; respiratory; responses; resveratrol; ring; role; salidroside; sars; sepsis; septic; serum; sinensis; structure; studies; surface; tea; tnf; treatment; viral; virus; viruses; vivo cache: cord-348391-xytmq2f2.txt plain text: cord-348391-xytmq2f2.txt item: #100 of 105 id: cord-349201-d88g5toc author: Yu, Feng title: Exploring the biomarkers associated with different host inflammation of acute respiratory distress syndrome (ARDS) from lung metabolomics in mice date: 2020-10-13 words: 6163 flesch: 44 summary: The severity of lung injury was evaluated. The four following indicators of lung injury were used to arrive at this score: alveolar congestion; bleeding; gap or vascular wall neutrophil infiltration or aggregation; and alveolar septal thickening or transparent membrane formation. keywords: acid; acute; ali; alveolar; amino; analysis; ards; article; balf; biomarkers; blood; cells; clinical; clp; clp group; clp‐splen; compounds; conditions; copyright; corresponding; damage; data; differential; distress; effect; experimental; expression; figure; group; higher; host; hyper; hypo; important; induced; inflammation; inflammatory; injury; levels; lps; lps groups; lung; lung injury; marks; mass; metabolic; metabolites; metabolomics; method; mice; model; mortality; n=12; neutrophil; organic; pathways; patients; pbs; phenotypes; plasma; post; potential; production; rate; related; respiratory; response; rights; risk; role; samples; score; sepsis; serum; severe; severity; significant; splen; splen group; splenectomy; studies; study; subgroup; syndrome; system; temperature; tissue; tnf; total cache: cord-349201-d88g5toc.txt plain text: cord-349201-d88g5toc.txt item: #101 of 105 id: cord-351310-6p42b144 author: Bohr, Adam title: Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-α siRNA with PAMAM dendrimers in a murine model date: 2020-08-13 words: 4349 flesch: 45 summary: Mechanistic profiling of the release kinetics of siRNA from lipidoidpolymer hybrid nanoparticles in vitro and in vivo after pulmonary administration Overcoming the challenges of siRNA delivery: nanoparticle strategies Nanoscale particles for lung delivery of siRNA Knocking down barriers: advances in siRNA delivery Rational design of cationic lipids for siRNA delivery Current progress in gene delivery technology based on chemical methods and nano-carriers Non-viral methods for siRNA delivery Dendrimers and hyperbranched polymers Nanomaterials based on phosphorus dendrimers Anti-Inflammatory Effect of Anti-TNF-α SiRNA Cationic Phosphorus Dendrimer Nanocomplexes Administered Intranasally in a Murine Acute Lung Injury Model Dendrimers for siRNA delivery Delivering siRNA with Dendrimers: In Vivo Applications Poly (amidoamine)(PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy Chitosan/siRNA Nanoparticle-mediated TNF-α Knockdown in Peritoneal Macrophages for Antiinflammatory Treatment in a Murine Arthritis Model Comparison of Polymeric siRNA Nanocarriers in a Murine LPS-Activated Macrophage Cell Line: Gene Silencing, Toxicity and Off-Target Gene Expression IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger Local stimulation of alpha7 cholinergic receptors inhibits LPS-induced TNF-alpha release in the mouse lung Van Der Poll, the LPS-Induced Lung Inflammation In Vivo 1 Elucidating the molecular mechanism of PAMAM-siRNA dendriplex self-assembly: Effect of dendrimer charge density Polyamidoamine dendrimers with a modified pentaerythritol core having high efficiency and low cytotoxicity as gene carriers Overcoming the innate immune response to small interfering RNA, Hum Chemical modification of siRNAs to improve serum stability without loss of efficacy Effect of the Route of Administration and PEGylation of Poly(amidoamine) Dendrimers on Their Systemic and Lung Cellular Biodistribution Polyamidoamine dendrimers can improve the pulmonary absorption of insulin and calcitonin in rats PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats Nasal lipopolysaccharide challenge and cytokine measurement reflects innate mucosal immune responsiveness A prominent role for airway epithelial NF-κB activation in lipopolysaccharide-induced airway inflammation Acute Lung Injury: Prevention May Be the Best Medicine Living with chronic obstructive pulmonary disease: a survey of patients' knowledge and attitudes In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery to the pulmonary endothelium Anti-TNFα therapy in inflammatory lung diseases Elucidating the role of surface chemistry on cationic phosphorus dendrimer-siRNA complexation The authors would like to thank the Danish Council for Independent Research The PAMAM dendrimer-siRNA complexes (dendriplexes) displayed strong siRNA condensation and high cellular uptake in macrophages compared with non-complexed siRNA. keywords: acute; administration; agents; anti; bal; cationic; cells; cellular; challenge; chronic; complexed; concentration; control; culture; delivery; dendrimers; dendriplexes; density; effect; efficacy; efficient; figure; flow; france; gene; high; inflammation; inflammatory; inhibition; levels; local; low; lps; lung; macrophages; mice; model; murine; negative; non; pamam; pbs; positive; potential; prepared; pulmonary; ratio; raw264.7; response; samples; silencing; sirna; stability; studies; study; therapeutic; time; tnf; transfection; treatment; uptake; vivo cache: cord-351310-6p42b144.txt plain text: cord-351310-6p42b144.txt item: #102 of 105 id: cord-351730-qmbo1dmo author: Kesherwani, Rashmi title: Euglena tuba extract provides protection against lipopolysaccharide-induced inflammatory response and oxidative stress in mice date: 2020-10-21 words: 3290 flesch: 42 summary: Oxidative stress and inflammatory markers were significantly increased in the LPS treated group, whereas ETME treated group at different concentrations protected mice from pro inflammatory cytokines and oxidative stress. A significant reduction is seen in both ETME groups of mice when compared with LPS group. keywords: acid; activity; animals; antioxidant; body; catalase; compounds; control; cytokines; different; effect; endotoxin; enzyme; et al; etme; euglena; extract; fig; flavonoids; free; group; inflammation; inflammatory; level; lipid; lps; lps group; mda; mice; nitric; oxidative; oxidative stress; oxide; peroxidation; protein; radical; respect; response; results; samples; sepsis; serum; sgpt; significant; sod; stress; superoxide; tuba; water; weight cache: cord-351730-qmbo1dmo.txt plain text: cord-351730-qmbo1dmo.txt item: #103 of 105 id: cord-352219-z245sb3s author: Tallam, Aravind title: Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages date: 2016-02-12 words: 9137 flesch: 37 summary: Gene expression analysis of infected mice resulted in the grouping of differentially expressed genes into different clusters based on the dependence of gene expression on IFNγ or IRF1. Irg1 was classified to the cluster of genes whose expression is mostly dependent on Irf1, but less on IFNγ However, taking the side of the discussion that human macrophages do not express iNOS, IRF1 plays a crucial role in mediating antimicrobial responses through IRG1 gene regulation in human immune cells. keywords: acid; activation; algorithm; analysis; antibody; approaches; binding; biological; blood; cad; catalogue; cebpb; cells; cellular; cis; conditions; cycle; data; dependent; different; dna; enzyme; essentiality; experiments; expression; factor; fig; filter; following; gene; gene expression; genome; grn; high; hours; human; human macrophages; ifn; ifnγ; images; immune; inducible; induction; infections; inference; inflammatory; information; inos; interactions; interferon; invitrogen; irf1; irg1; irg1 expression; itaconic; levels; life; line; lipopolysaccharide; literature; lps; macrophages; manufacturer; match; medium; merged; methods; metric; mitochondria; monocytes; mouse; murine; myd88; network; nitric; nodes; non; number; oxide; pass; paths; pathway; pbmcs; pbs; pixels; plates; potential; primary; production; protein; raw264.7; regulated; regulation; regulatory; response; results; role; samples; sequences; sigma; silencing; sirna; sites; size; species; specific; stimulation; stimuli; studio; synthase; systems; targeting; temperature; time; total; transcriptional; transfac; type; wide cache: cord-352219-z245sb3s.txt plain text: cord-352219-z245sb3s.txt item: #104 of 105 id: cord-354765-abayh871 author: Graham, R. S. title: Calming the Cytokine Storm - Splenic Ultrasound for Treating Inflammatory Disorders and Potentially COVID-19 date: 2020-07-17 words: 8854 flesch: 35 summary: In healthy individuals, a single three-minute administration of splenic ultrasound stimulation significantly inhibits whole blood TNF production upon ex vivo exposure to endotoxin compared to sham controls. Further supporting the human results, we also demonstrated that splenic ultrasound stimulation in a rodent model achieves a reduction across a number of proinflammatory cytokines beyond TNF, including IL-6, IFNγ, IL-1β, IL-1α, and IL-12 in splenic lysates (Fig. S1 ), which is consistent with previous reports using implanted vagus nerve stimulators (18, 44) . keywords: abcam; activation; acute; adaptive; analysis; animal; antibody; arthritis; blood; cd14; cell; cellular; cholinergic; chronic; clinical; components; consistent; control; covid-19; cytokine; daily; data; day; days; disease; effects; exposure; expression; fig; following; genes; group; healthy; human; ifnγ; il-1β; il-6; il-8; immune; infection; inflammation; inflammatory; injury; innate; invasive; key; levels; lps; migration; minutes; model; monocytes; multiple; nerve; neuroimmune; nfκb; non; number; paper; participants; pathway; patients; post; potential; previous; probe; production; regulation; release; research; response; results; rheumatoid; samples; sequencing; severe; sham; signaling; significant; single; spleen; splenic; splenic ultrasound; stimulated; stimulation; storm; studies; study; subjects; suppression; system; table; terms; test; tissue; tnf; transcripts; treatment; type; ultrasonographer; ultrasound; ultrasound stimulation; ultrasound treatment; vagus; viral cache: cord-354765-abayh871.txt plain text: cord-354765-abayh871.txt item: #105 of 105 id: cord-354829-god79qzw author: Mao, Kaimin title: Identification of robust genetic signatures associated with lipopolysaccharide-induced acute lung injury onset and astaxanthin therapeutic effects by integrative analysis of RNA sequencing data and GEO datasets date: 2020-09-23 words: 6341 flesch: 39 summary: Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission Astaxanthin alleviated acute lung injury by inhibiting oxidative/nitrative stress and the inflammatory response in mice Astaxanthin prevents against lipopolysaccharideinduced acute lung injury and sepsis via inhibiting activation of MAPK/NF-κB NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and metaanalysis clusterProfiler: an R package for comparing biological themes among gene clusters Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential Evidence for chemokine synergy during neutrophil migration in ARDS Fernández-Botrán R. Modulation of acute inflammation by targeting glycosaminoglycan-cytokine interactions Contribution of neutrophils to acute lung injury Antiinflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model C-X-C motif chemokine 13 (CXCL13) is a prognostic biomarker of idiopathic pulmonary fibrosis ZBP1: innate sensor regulating cell death and inflammation Dynamic gene expression analysis in a H1N1 influenza virus mouse pneumonia model The CC chemokine ligand 2 (CCL2) mediates fibroblast survival through IL-6 Complement inhibition decreases early fibrogenic events in the lung of septic baboons The cytokine-serum amyloid achemokine network Serum amyloid A is a biomarker of severe coronavirus disease and poor prognosis Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3 Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells IL-6 induced lncRNA MALAT1 enhances TNF-α expression in LPS-induced septic cardiomyocytes via activation of SAA3 Emerging functions of serum amyloid a in inflammation Suppression of lipopolysaccharide-induced inflammatory response by fragments from serum amyloid a Serum amyloid a promotes LPS clearance and suppresses LPS-induced inflammation and tissue injury Knockdown of miR-660 protects nucleus pulposus cells from TNF-a-induced apoptosis by targeting serum amyloid A1 IRF7: activation, regulation, modification and function Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza a virus Mir-302c mediates influenza a virus-induced IFNβ expression by targeting NF-κB inducing kinase Then, we performed a meta-analysis using NetworkAnalyst (http://www.networkanalyst.ca), which is a comprehensive web-based tool designed to perform meta-analyses of gene expression data [20] . keywords: activation; activity; acute; acute lung; administration; ali; amyloid; analysis; ards; ast; astaxanthin; biological; ccl7; cells; common; control; core; cxcl13; cxcl5; data; datasets; degs; disease; distress; effect; expression; factor; fibrosis; figure; function; genes; genetic; group; ihc; increased; induced; inflammation; inflammatory; influenza; injury; irf7; isg15; levels; lipopolysaccharide; lps; lps group; lung; lung injury; ly6i; meta; method; mice; microarray; models; molecular; mouse; networkanalyst; pathogenesis; patients; pbs; pcr; protein; pulmonary; qrt; related; research; respiratory; response; results; rna; robust; role; saa1; saa3; samples; seq; sequencing; serum; signatures; studies; study; supplementary; syndrome; table; therapeutic; timp1; tissue; total; treatment; upregulated; usa cache: cord-354829-god79qzw.txt plain text: cord-354829-god79qzw.txt