Bibliography

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1. cord-000254-bufbjdmw
   • author: Clement, Annick
   • title: Interstitial lung diseases in children
   • date: 2010-08-20
   • words: 15055
   • flesch: 31
   • summary: The diagnostic value of bronchoalveolar lavage in immunocompetent children with chronic diffuse pulmonary infiltrates The safety and efficacy of thoracoscopic lung biopsy for diagnosis and treatment in infants and children Diagnosis of interstitial lung disease by a percutaneous lung biopsy sample Combined percutaneous lung biopsy and high-resolution computed tomography in the diagnosis and management of lung disease in children key: cord-000254-bufbjdmw authors: Clement, Annick; Nathan, Nadia; Epaud, Ralph; Fauroux, Brigitte; Corvol, Harriet title: Interstitial lung diseases in children date: 2010-08-20 journal:
   • keywords: abca3; abnormalities; accumulation; activity; addition; adult; aec; age; aged; agents; alveolar; anti; antibodies; antigens; apoptosis; associated; association; bal; basement; biopsy; blood; bronchoalveolar; capacity; capillary; cases; cause; cells; cellular; changes; chest; childhood; children; chronic; classification; clinical; collagen; common; components; conditions; congenital; connective; csf; ctd; damage; deficiency; development; diagnosis; diffuse; disease; disorders; drugs; dysfunction; dysplasia; environmental; eosinophilic; epithelial; evaluation; evidence; exchange; exercise; exposure; expression; factors; failure; familial; fatal; features; fibrosis; fibrotic; findings; formation; forms; function; gas; gene; genetic; granulomatous; growth; high; histiocytosis; history; hrct; human; hyperplasia; idiopathic; ild; imaging; immune; impaired; important; incidence; individuals; infancy; infants; infection; infiltrates; inflammation; inflammatory; injury; interstitial; interstitial lung; investigations; involvement; langerhans; large; lavage; levels; limited; lipid; literature; long; lung; lung biopsy; lung disease; lymphatic; macrophages; manifestations; mechanisms; membrane; mesenchymal; mice; molecules; months; multiple; mutations; neonatal; neuroendocrine; new; non; number; older; outcome; oxygen; parenchymal; pathogenesis; pathological; pathways; patients; patterns; pediatric; pediatric ild; pneumonia; pneumonitis; potential; presence; presentation; primary; process; production; progression; protein; proteinosis; pulmonary; pulmonary alveolar; pulmonary disease; pulmonary fibrosis; rare; recent; receptor; repair; reported; reports; respiratory; response; result; review; role; rsv; sarcoidosis; serum; severe; situations; skin; small; specific; spectrum; stress; structure; studies; study; suggestive; surfactant; symptoms; syndrome; systemic; telomerase; term; tests; tgf; therapeutic; therapy; thyroid; tissue; treatment; type; underlying; variety; vasculitis; virus; years; young
   • versions: original; plain text
2. cord-000295-ft5wl70x
   • author: Tomankova, Tereza
   • title: Involvement of microRNAs in physiological and pathological processes in the lung
   • date: 2010-11-23
   • words: 4783
   • flesch: 39
   • summary: [102] miR-34 regulation of apoptosis in lung cancer cells (H) [66] , [67] function as tumor suppressors in lung cells.
   • keywords: ago; airway; allergic; analysis; apoptosis; asthma; bronchial; cancer; cells; cluster; coding; copd; degradation; development; dicer; diseases; downregulation; epithelial; evidence; experimental; expression; family; fibroblasts; fibrosis; function; genes; homeostasis; human; immune; induced; inflammation; inflammatory; inhibition; involvement; knowledge; let-7; long; lung; mechanism; microrna; mir-126; mir-133a; mir-146a; mir-155; mir-17; mir-21; mir-223; mirnas; mrna; murine; non; normal; nucleotides; pathological; physiological; prediction; processes; profiles; protein; pulmonary; reduced; regulation; role; short; small; specific; strand; studies; study; suppressor; table; target; timing; tumor
   • versions: original; plain text
3. cord-000307-iv18eiap
   • author: Capelozzi, Vera Luiza
   • title: Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine‐origin influenza type A/H1N1 and acute respiratory failure
   • date: 2010-12-17
   • words: 3987
   • flesch: 35
   • summary: According to the World Health Organization (WHO), between 25 April and 11 October 2009, 399,232 confirmed cases of H1N1 influenza virus and 4,735 deaths occurred throughout the world. Secretaria de Vigilâ ncia em Saú de Pneumonia and respiratory failure from swine-origin influenza a (H1N1) in Mexico Severe respiratory disease concurrent with the circulation of H1N1 influenza Impact of open lung biopsy on refractory acute respiratory failure Open lung biopsy in patients on mechanical ventilation with suspected diffuse lung disease A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients Usefulness of open lung biopsy in mechanically ventilated patients with undiagnosed diffuse pulmonary infiltrates: influence of comorbidities and organ dysfunction Host defense function of the airway epithelium in health and disease: clinical background Defense mechanisms against influenza virus infection in the respiratory tract mucosa An expanded definition of the adult respiratory distress syndrome Recruitment maneuver in pulmonary and extrapulmonary experimental acute lung injury Pulmonary lesion induced by low and high positive end-expiratory pressure levels during protective ventilation in experimental acute lung injury COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung.
   • keywords: acute; aecs; alveolar; analysis; antibodies; arf; bronchiolar; cases; ccc; cells; changes; clone; dad; days; dilution; disease; epithelial; expression; failure; fatal; features; figure; findings; h1n1; immune; infection; influenza; injury; like; lung; lymphocytes; macrophages; membrane; multinucleated; necrosis; novel; oiv; olb; origin; particles; pathological; pathology; patients; presence; primary; pulmonary; respiratory; response; semiquantitative; series; severe; study; swine; syndrome; target; tissue; treatment; trs; ultrastructural; viral; virus
   • versions: original; plain text
4. cord-000492-ec5qzurk
   • author: Devaney, James
   • title: Clinical Review: Gene-based therapies for ALI/ARDS: where are we now?
   • date: 2011-06-20
   • words: 6021
   • flesch: 34
   • summary: Antibodies that bind antigens selectively expressed on the pulmonary endothelial surface can be complexed to gene vectors to facilitate selective targeting following intravenous administration + ,K + -ATPase rescues endotoxin-induced lung injury Interleukin-10 gene transfer: prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis Nonviral gene delivery with indoleamine 2,3-dioxygenase targeting pulmonary endothelium protects against ischemia-reperfusion injury Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, infl ammation, and neutrophil infl ux after hemorrhagic shock and sepsis Caveolin-1 siRNA increases the pulmonary microvascular and alveolar epithelial permeability in rats Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fi brosis Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension Microvascular regeneration in established pulmonary hypertension by angiogenic gene transfer Tetracycline-inducible transgene expression mediated by a single AAV vector Effi cient transfection of non-proliferating human airway epithelial cells with a synthetic vector system Tailoring the AAV vector capsid for gene therapy Artifi cial evolution with adeno-associated viral libraries Analysis and optimization of the cationic lipid component of a lipid/ peptide vector formulation for enhanced transfection in vitro and in vivo Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell CpG-free plasmids confer reduced infl ammation and sustained pulmonary gene expression Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12 Targeting type II and Clara cells for adenovirus-mediated gene transfer using the surfactant protein B promoter Development of lentiviral vectors with regulated respiratory epithelial expression in vivo Expression of CFTR from a ciliated cell-specifi c promoter is ineff ective at correcting nasal potential diff erence in CF mice A human epithelium-specifi c vector optimized in rat pneumocytes for lung gene therapy Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Use of a new generation reverse tetracycline transactivator system for quantitative control of conditional gene expression in the murine lung Construction of an rtTA2(s)-m2/ tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates Adenoviral vector transfection into the pulmonary epithelium after cecal ligation and puncture in rats Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins aff ects the transduction effi ciency of recombinant vectors GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense Clinical Review: Gene-based therapies for ALI/ARDS: where are we now?
   • keywords: -atpase; aav; acute; adenoviral; administration; airway; ali; ammation; animal; approaches; ards; barriers; brosis; cacy; capsid; cationic; cell; ciency; cient; clinical; cystic; defense; defi; delivery; development; distress; dna; ective; effi; endothelial; endotoxin; epithelial; expression; factor; function; gene; genome; high; human; infection; infl; injury; ischemia; lipid; lung; mechanisms; models; modifi; multiple; nonviral; oligonucleotides; overexpression; patients; plasmid; potential; preclinical; process; promise; promoters; protein; pulmonary; repair; reperfusion; respiratory; risk; rna; sirna; specifi; stem; strategies; studies; syndrome; table; targeting; targets; therapeutic; therapies; therapy; tissue; transfection; transfer; transgene; use; vectors; viral; virus
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5. cord-001117-llb4f74a
   • author: Ji, Wen-Jie
   • title: Spironolactone Attenuates Bleomycin-Induced Pulmonary Injury Partially via Modulating Mononuclear Phagocyte Phenotype Switching in Circulating and Alveolar Compartments
   • date: 2013-11-19
   • words: 4983
   • flesch: 28
   • summary: In addition, recent studies demonstrated that lung alveolar macrophages are established prior to birth and maintains themselves subsequently during adulthood independent of replenishment from circulating monocyte input in steady state Second, we did not observed significant changes in lung interstitial macrophages by spironolactone.
   • keywords: activation; acute; aldosterone; alternative; alveolar; alveolar macrophages; analysis; angiotensin; antagonism; anti; antibody; balf; bleomycin; blood; cells; circulating; clone; collagen; cytometry; day; disease; drug; effect; evidence; expansion; experimental; expression; f4/80; fibrosis; figure; flow; groups; hypertension; inflammation; inflammatory; inhibition; injury; interstitial; levels; like; lung; lung injury; ly6c; macrophages; mice; mineralocorticoid; monocytes; mononuclear; mouse; mrna; myeloid; neutrophil; pathogenesis; pcr; phagocyte; phenotype; polarization; potential; protein; pulmonary; recent; receptor; resident; response; role; saline; samples; spironolactone; studies; study; switching; therapeutic; time; tissue; total; treatment; usa; work
   • versions: original; plain text
6. cord-001473-aki28lhp
   • author: Chen, Qi Xing
   • title: Silencing airway epithelial cell-derived hepcidin exacerbates sepsis-induced acute lung injury
   • date: 2014-08-06
   • words: 4521
   • flesch: 40
   • summary: These results demonstrated that in the current study the intratracheal administration of Ad-shHepc1 only silenced the hepcidin gene transcription in AECs, which was in accordance with previous studies that adenovirus-mediated intratracheal gene delivery specifically inhibited targeted gene expression in lung epithelial cells but not in alveolar macrophages and other organs [29, 30] . A systematic review Mortality rates for patients with acute lung injury/ARDS have decreased over time Human defensins and LL-37 in mucosal immunity Hiemstra PS: Defensins and cathelicidins in inflammatory lung disease: beyond antimicrobial activity Expression and activity of beta-defensins and LL-37 in the developing human lung Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection High concentrations of alpha-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome Protection against Pseudomonas aeruginosa pneumonia and sepsis-induced lung injury by overexpression of beta-defensin-2 in rats Hepcidin and iron regulation, 10 years later Fine tuning of hepcidin expression by positive and negative regulators Hepcidin in human iron disorders: therapeutic implications Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice Hepcidin and the iron-infection axis Iron in innate immunity: starve the invaders Two to tango: regulation of mammalian iron metabolism Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice Hepcidin expression in human airway epithelial cells is regulated by interferon-γ Functional differences between hepcidin 1 and 2 in transgenic mice Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia Triggering receptor expressed on myeloid cells-2 protects against polymicrobial sepsis by enhancing bacterial clearance Hussell T: A critical function for CD200 in lung immune homeostasis and the severity of influenza infection Hepatic iron concentration does not predict response to standard and pegylated-IFN/ribavirin therapy in patients with chronic hepatitis C Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination
   • keywords: acute; adenovirus; aecs; airway; airway epithelial; ali; alveolar; alveolar macrophages; analysis; antibody; antimicrobial; ards; bacterial; balf; cells; clp; content; control; current; epithelial; epithelial cells; expression; ferroportin; figure; function; gene; hepcidin; hepcidin knockdown; hours; human; immune; important; infection; inflammation; inflammatory; injury; intracellular; iron; kit; knockdown; knockdown mice; lavage; level; liver; lung; lung injury; macrophages; manuscript; metabolism; mice; minutes; model; mortality; mouse; polymicrobial; protein; pulmonary; response; rna; role; saline; sepsis; severe; shhepc1; shneg; studies; study; system; total; usa
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7. cord-001945-ueccexxc
   • author: Yang, Ce
   • title: Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury
   • date: 2016-02-11
   • words: 6710
   • flesch: 30
   • summary: Recently, the discovery of human lung stem cells and their relevant studies has opened the door of hope again, which might put us on the path to repair our injured body parts, lungs on demand. Presently, as compared with the boosting of murine lung stem cells, the investigation of human lung stem cells (HLSCs) remains superficial since their presentation by Kajstura et al in 2011 [81] .
   • keywords: acute; acute lung; adipose; adscs; adult; airway; ali; alveolar; anti; at2; bascs; blood; bone; bone marrow; bronchioalveolar; capacity; cells; clara; clinical; cord; courses; development; differentiation; distress; effects; efficacy; endogenous; endothelial; epcs; epithelial; evidence; factor; fetal; fluid; functional; growth; human; immune; increase; induced; inflammation; inflammatory; injured; injury; ipscs; lps; lung; lung cells; lung injury; lung stem; marrow; mesenchymal; mesenchymal stem; mice; mobilization; mscs; murine; new; number; paracrine; pathway; peripheral; placenta; pluripotent; potential; progenitor; progenitor cells; protective; pulmonary; rats; regeneration; remodeling; repair; repairing; respiratory; responses; role; specific; stem; stem cells; stromal; studies; syndrome; therapeutic; therapy; tissues; transplantation; treatment; type; umbilical; vivo
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8. cord-002627-3jwu4pf2
   • author: Wu, Nan-Chun
   • title: Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation
   • date: 2017-07-26
   • words: 8515
   • flesch: 34
   • summary: Five hours of LTV ventilation did not induce a major change in lung function, whereas 5 h of HTV ventilation induced apparent combined restrictive and obstructive lung disorder, together with increased pulmonary oxidative stress, decreased anti-oxidative activity and increased lung inflammation (P < 0.05). Results: Five hours of LTV ventilation did not induce a major change in lung function, whereas 5 h of HTV ventilation induced apparent combined restrictive and obstructive lung disorder, together with increased pulmonary oxidative stress, decreased anti-oxidative activity and increased lung inflammation (P < 0.05).
   • keywords: activation; acute; addition; adhesion; administration; airway; alveolar; antioxidant; associated; authors; balf; baseline; bioavailability; blood; cell; combined; count; course; data; defense; differential; dismutase; dysfunction; endothelial; expression; extracellular; factor; formation; function; group; high; htv; htv ventilation; human; hydroxyl; immune; impairment; increased; induced; inflammation; inflammatory; injury; inos; intravenous; lavage; level; lipid; lobe; low; ltv; lung; lung function; lung inflammation; lung injury; matrix; mda; mechanical; mechanical ventilation; membrane; mice; mmp-9; molecular; mrna; necrosis; neutrophil; nitric; obstructive; oxidative; oxidative stress; patients; peroxidation; pressure; protective; protein; pulmonary; pulmonary oxidative; radical; rats; reported; resistance; respiratory; response; restrictive; right; role; serum; sod; stress; study; superoxide; surfactant; system; tidal; tissue; tnf; treatment; usa; vascular; vcam-1; ventilation; volume; water; white; zn sod
   • versions: original; plain text
9. cord-003558-7lvqpz21
   • author: Davies, Patrick
   • title: Clinical Scenarios of the Application of Electrical Impedance Tomography in Paediatric Intensive Care
   • date: 2019-03-29
   • words: 4016
   • flesch: 41
   • summary: Absolute electrical impedance tomography (aEIT) guided ventilation therapy in critical care patients: Simulations and future trends Effect of closed endotracheal suction in high-frequency ventilated premature infants measured with electrical impedance tomography Assessment of lung ventilation in infants with respiratory distress syndrome using electrical impedance tomography Electrical impedance tomography monitoring in acute respiratory distress syndrome patients with mechanical ventilation during prolonged positive end-expiratory pressure adjustments Lung recruitment and endotracheal suction in ventilated preterm infants measured with electrical impedance tomography Identification of regional overdistension, recruitment and cyclic alveolar collapse with electrical impedance tomography in an experimental ARDS model Assessment of Lung Recruitment by Electrical Impedance Tomography and Oxygenation in ARDS Patients Positive end expiratory pressure titration after alveolar recruitment directed by electrical impedance tomography Assessment of regional lung recruitment and derecruitment during a PEEP trial based on electrical impedance tomography Bedside measurement of changes in lung impedance to monitor alveolar ventilation in dependent and nondependent parts by electrical impedance tomography during a positive end-expiratory pressure trial in mechanically ventilated intensive care unit patient Assessment of respiratory system compliance with electrical impedance tomography using a positive endexpiratory pressure wave maneuver during pressure support ventilation: a pilot clinical study Protective ventilation using electrical impedance tomography Monitoring of recruitment and derecruitment by electrical impedance tomography in a model of acute lung injury End-expiratory lung impedance change enables bedside monitoring of end-expiratory lung volume change Regional respiratory time constants during lung recruitment in high-frequency oscillatory ventilated preterm infants Slow moderate pressure recruitment maneuver minimizes negative circulatory and lung mechanic side effects: Evaluation of recruitment maneuvers using electric impedance tomography Bedside selection of positive end-expiratory pressure by electrical impedance tomography in hypoxemic patients: a feasibility study Oxygen delivery through high-flow nasal cannulae increase end-expiratory lung volume and reduce respiratory rate in post-cardiac surgical patients Effect of High Flow Nasal Cannula and Body Position on End-Expiratory Lung Volume. A Cohort Study Using Electrical Impedance Tomography Electrical impedance tomography (EIT) for quantification of pulmonary edema in acute lung injury Electrical Impedance Tomography: The Realization of Regional Ventilation Monitoring Chest electrical impedance tomography examination, data analysis, terminology, clinical use and recommendations: consensus statement of the TRanslational EIT developmeNt stuDy group Positive end-expiratory pressure optimization using electric impedance tomography in morbidly obese patients during laparoscopic gastric bypass surgery Bedside estimation of recruitable alveolar collapse and hyperdistension by electrical impedance tomography Non-invasive radiation-free monitoring of regional lung ventilation in critically ill infants Computed tomography-an increasing source of radiation exposure Regional ventilation distribution in the first 6 months of life P.D. conceived the paper and coordinated contributions from the clinical team.
   • keywords: acute; assessment; bedside; benefits; care; change; chest; children; clinical; collapse; data; distribution; effects; eit; electrical; electrical impedance; electrodes; end; expansion; global; high; images; impedance; impedance tomography; information; intensive; knowledge; lobar; loss; lung; monitoring; non; paediatric; patient; peep; physiotherapy; positive; pressure; radiation; real; recruitment; regional; relative; respiratory; right; settings; significant; team; technology; time; tomography; treatment; understanding; use; ventilation; ventilatory; volume; weaning
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10. cord-003655-uo0hdrgc
    • author: de Vries, Rory D.
    • title: Paramyxovirus Infections in Ex Vivo Lung Slice Cultures of Different Host Species
    • date: 2018-03-27
    • words: 3073
    • flesch: 51
    • summary: Here, we describe a protocol for the preparation and ex vivo infection of lung slices from different mammalian host species with various respiratory paramyxoviruses expressing fluorescent reporter proteins, and suggest follow-up experiments including immunohistochemistry, flow cytometry and confocal microscopy. Lung slices are also suitable for analysis by immunohistochemistry, thereby visualizing virus cell tropism and spatial localization of infected cells within the tissue.
    • keywords: agarose; animal; bronchus; cells; cilia; confocal; critical; culture; cytometry; dependent; end; experiments; flow; fluorescent; infected; infection; inflated; inflation; lung; measles; medium; microscopy; point; primary; proteins; reporter; respiratory; single; size; slices; species; step; syringe; time; trachea; tropism; viable; video; virus; viruses; vivo
    • versions: original; plain text
11. cord-004092-wb150n8w
    • author: Nieman, Gary F.
    • title: Prevention and treatment of acute lung injury with time-controlled adaptive ventilation: physiologically informed modification of airway pressure release ventilation
    • date: 2020-01-06
    • words: 8073
    • flesch: 43
    • summary: Summary of the experimental evidence for the clinical practice guideline Looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury Airway pressure release ventilation reduces conducting airway micro-strain in lung injury Visualizing the propagation of acute lung injury Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation? An experimental porcine study Stress distribution in lungs: a model of pulmonary elasticity Alterations of mechanical properties and morphology in excised rabbit lungs rinsed with a detergent Physiology in Medicine: understanding dynamic alveolar physiology to minimize ventilator-induced lung injury Alveolar derecruitment and collapse induration as crucial mechanisms in lung injury and fibrosis Alveolitis and collapse in the pathogenesis of pulmonary fibrosis Mechanical ventilation-associated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome Opening pressures and atelectrauma in acute respiratory distress syndrome Does high PEEP prevent alveolar cycling? Effect of lung recruitment and titrated positive endexpiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial Alveolar instability (atelectrauma) is not identified by arterial oxygenation predisposing the development of an occult ventilatorinduced lung injury Effects of respiratory rate, plateau pressure, and positive end-expiratory pressure on PaO2 oscillations after saline lavage A fibre optic oxygen sensor that detects rapid PO2 changes under simulated conditions of cyclical atelectasis in vitro Unstable inflation causing injury: insight from prone position and paired CT scans Deterioration of regional lung strain and inflammation during early lung injury Tidal changes on CT and progression of ARDS Lung inhomogeneities and time course of ventilator-induced mechanical injuries Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury Effect of airway pressure release ventilation on dynamic alveolar heterogeneity Mechanisms of surface-tensioninduced epithelial cell damage in a model of pulmonary airway reopening The influence of non-equilibrium surfactant dynamics on the flow of a semi-infinite bubble in a rigid cylindrical capillary tube Biomechanics of liquid-epithelium interactions in pulmonary airways Tidal ventilation at low airway pressures can augment lung injury Airway closure in acute respiratory distress syndrome: an underestimated and misinterpreted phenomenon Alveolar volume-surface area relation in air-and saline-filled lungs fixed by vascular perfusion Influence of forced inflations on the creep of lungs and thorax in the dog Alveolar micromechanics in bleomycin-induced lung injury Lung inhomogeneity in patients with acute respiratory distress syndrome Micromechanics of alveolar edema Local strain distribution in real three-dimensional alveolar geometries Stress concentration around an atelectatic region: a finite element model Acute respiratory distress syndrome Never give the lung the opportunity to collapse Preemptive mechanical ventilation based on dynamic physiology in the alveolar microenvironment: novel considerations of time-dependent properties of the respiratory system Last Word on Viewpoint: looking beyond macroventilatory parameters and rethinking ventilator-induced lung injury Regional behavior of airspaces during positive pressure reduction assessed by synchrotron radiation computed tomography The effect of positive end-expiratory pressure on lung micromechanics assessed by synchrotron radiation computed tomography in an animal model of ARDS Dynamic mechanical interactions between neighboring airspaces determine cyclic opening and closure in injured lung Individual airway closure characterized in vivo by phase-contrast ct imaging in injured rabbit lung Ventilator-induced lung injury and lung mechanics Limiting ventilator-associated lung injury in a preterm porcine neonatal model Early application of airway pressure release ventilation may reduce mortality in high-risk trauma patients: a systematic review of observational trauma ARDS literature Alveolar leak develops by a rich-get-richer process in ventilatorinduced lung injury Lung tissue viscoelasticity: a mathematical framework and its molecular basis Lung parenchymal mechanics Lung parenchymal mechanics in health and disease Modeling the complex dynamics of derecruitment in the lung Respiratory mechanics in anesthetized paralyzed humans: effects of flow, volume, and time Differential susceptibility of diaphragm muscle fibers to neuromuscular transmission failure Lung mechanics.
    • keywords: acute; acute respiratory; adaptive; airway; airway pressure; alveolar; alveoli; applied; approach; aprv; ards; ardsnet; behavior; brain; breath; brief; changes; cmh; collapse; compliance; cpap; critical; current; curve; dead; dependent; distress; donor; duration; dynamic; expiration; expiratory; extended; fig; flow; gas; high; increase; initial; injury; inspiration; inspiratory; lung; lung injury; mechanical; method; microenvironment; min; model; mortality; normal; open; opening; parenchymal; patients; peep; phase; positive; pressure; protective; pulmonary; recruitment; regional; release; release phase; review; right; settings; short; slope; spring; strain; study; syndrome; system; tcav; tidal; time; tissue; ventilation; vili; viscoelastic; volume
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12. cord-004405-l5rif2lu
    • author: Bleyer, Martina
    • title: Spontaneous lung pathology in a captive common marmoset colony (Callithrix jacchus)
    • date: 2017-03-01
    • words: 3881
    • flesch: 27
    • summary: However, aspiration of larger or sharp-edged foreign bodies may result in substantial tissue reaction and An outbreak of Bordetella bronchiseptica pneumonia in a colony of common marmosets (Callithrix jacchus) Nonhuman primate model for the study of respiratory Klebsiella pneumoniae infection Tumors of the respiratory tract observed at the German Primate Center A survey of the pathology of marmosets (Callithrix jacchus) derived from a marmoset breeding unit Airway hyper-responsiveness in lipopolysaccharid-challenged common marmosets (Callithrix jacchus) Respiratory animal models in the common marmoset (Callithrix jacchus) Spontaneous pathology of the common marmoset (Callithrix jacchus) and tamarins (Saguinus oedipus, Saguinus mystax) Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus Hypervitaminosis D in New World monkeys Background pathology of the common marmoset (Callithrix jacchus) in toxicological studies Experimental respiratory anthrax infection in the common marmoset (Callithrix jacchus) Respiratory system Non-human primates in biomedical research: diseases Background lesions in laboratory animals, a color atlas Hepatic hemosiderosis in common marmosets, Callithrix jacchus: effect of diet on incidence and severity Husbandry and management of New World species: marmosets and tamarins, diseases, in: The laboratory primate Non-human primate diseases of relevance in drug development and their impact on the interpretation of study findings, in: The non-human primate in nonclinical drug development and safety assessment Histopathology of incidental findings in cynomolgus monkeys (Macaca fascicularis) used in toxicity studies S: LPS-induced lung inflammation in marmoset monkeys for testing of anti-inflammatory drugs Bacterial and mycotic disease of non-human primates, in: Non-human primates in biomedical research: diseases The common marmoset (Callithrix jacchus) as a model in toxicology Acknowledgements. Primate Biol DOI: 10.5194/pb-4-17-2017 sha: doc_id: 4405 cord_uid: l5rif2lu Data on spontaneous pathology are substantially scarce for common marmosets, compared to other laboratory animals, but is essential for the interpretation of histological findings in the context of toxicological and experimental studies.
    • keywords: acute; adult; affected; air; alveolar; animals; atelectasis; background; bacterial; callithrix; cases; cell; center; changes; colony; common; common marmosets; death; disease; et al; evidence; experimental; fig; findings; german; hemosiderosis; histological; human; immaturity; incidence; inflammatory; interstitial; jacchus; juvenile; klebsiella; laboratory; lesions; lobar; lung; lópez; majority; marmosets; mineralization; multifocal; newborn; non; pathology; pneumonia; present; primate; pulmonary; respiratory; species; spontaneous; stain; studies; study; tissue; toxicological; tumors
    • versions: original; plain text
13. cord-005228-187d3pxz
    • author: Wang, Jian
    • title: Role of microbiota on lung homeostasis and diseases
    • date: 2017-10-09
    • words: 5007
    • flesch: 26
    • summary: The function of intestinal microbiota in modulating mucosal homeostasis and defense has been widely studied; however, the potential function of lung microbiota in regulating immunity and homeostasis has just begun. In this review, we describe the distribution and composition of microbiota in the respiratory system and discuss the potential function of lung microbiota in both health and acute/chronic lung disease.
    • keywords: airway; allergic; alveolar; asthma; axis; bacterial; bacteroidetes; bowel; cells; change; chronic; common; communities; composition; copd; culture; development; different; disease; environmental; et al; factors; fibrosis; free; function; gut; health; homeostasis; host; human; idiopathic; immune; immunity; independent; infection; inflammation; inflammatory; influence; influenza; intestinal; intestinal microbiota; ipf; lower; lung; lung disease; lung microbiota; mice; microbial; microbiota; mucosal; obstructive; pathogenesis; patients; potential; progression; pulmonary; respiratory; respiratory tract; response; risk; role; similar; specific; staphylococcus; studies; system; th2; tissues; tract; upper; wang
    • versions: original; plain text
14. cord-005476-q6o5239w
    • author: Griesenbach, U
    • title: Gene therapy for cystic fibrosis: an example for lung gene therapy
    • date: 2004-09-29
    • words: 5913
    • flesch: 36
    • summary: The cells of the pulmonary airways The Molecular and Metabolic Basis of Inherited Disease Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer Expression of the cystic fibrosis gene in adult human lung Immunological hurdles to lung gene therapy Delivery of gene transfer vectors to lung: obstacles and the role of adjunct techniques for airway administration Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis Retargeting the coxsackievirus and adenovirus receptor to the apical surface of polarized epithelial cells reveals the glycocalyx as a barrier to adenovirus-mediated gene transfer Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract Aerosol delivery of a beta-galactosidase adenoviral vector to the lungs of rodents Adenovirus-mediated persistent cystic fibrosis transmembrane conductance regulator expression in mouse airway epithelium Safety of local delivery of low-and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. Initial results for lung gene transfer are encouraging and demonstrate that the transfection efficiency of naked DNA can be enhanced in the presence of electrical fields 49 (and Ian Pringle, personal communication).
    • keywords: aav2; able; addition; adenovirus; administration; aecs; airway; animal; apical; cdna; cells; cf gene; cftr; chloride; chronic; clinical; complex; complexes; cystic; cystic fibrosis; days; defect; delivery; disease; dna; efficiency; end; endogenous; epithelial; expression; fibrosis; gene; gene expression; gene therapy; gene transfer; good; gta; gtas; human; immune; important; likely; liposome; low; lung; membrane; mice; models; mouse; mrna; nasal; nonviral; patients; phase; plasmid; points; promoter; proteins; pulmonary; receptor; repair; repeat; results; safety; sev; single; small; specific; strategies; surface; systemic; targeting; therapy; transfection; transfer; transport; trials; type; uptake; vectors; virus; viruses; vivo; wild
    • versions: original; plain text
15. cord-005573-mryrl1s1
    • author: Raimondi, Francesco
    • title: Point-of-care lung ultrasound in neonatology: classification into descriptive and functional applications
    • date: 2018-07-20
    • words: 5979
    • flesch: 34
    • summary: Authors' reply Lung ultrasound findings in meconium aspiration syndrome Lung ultrasonography to diagnose meconium aspiration syndrome of the newborn Bedside ultrasonography for diagnosis of pneumothorax Pleural ultrasonography versus chest radiography for the diagnosis of pneumothorax: review of the literature and meta-analysis Lung ultrasound-guided emergency pneumothorax needle aspiration in a very preterm infant Lung ultrasound diagnostic accuracy in neonatal pneumothorax Lung ultrasonography to diagnose pneumothorax of the newborn Lung ultrasound for diagnosing pneumothorax in the critically ill neonate Lung ultrasound: an useful tool for the follow-up of neonatal localized interstitial emphysema Pneumomediastinum as a sonographic mimic of pneumothorax The still lung point: new sonographic evidence for pneumomediastinum Lung ultrasonography for the diagnosis of severe neonatal pneumonia Routine application of lung ultrasonography in the neonatal intensive care unit Lung ultrasound for the diagnosis of pneumonia in children: a meta-analysis Systematic review and meta-analysis for the use of ultrasound versus radiology in diagnosing of pneumonia Lung ultrasound for the diagnosis of pneumonia in adults: a metaanalysis Accuracy and applications of lung ultrasound to diagnose ventilator-associated pneumonia: a systematic review Lung ultrasound in bronchiolitis: comparison with chest X-ray Can a simple lung ultrasound score predict length of ventilation for infants with severe acute viral bronchiolitis? Acute respiratory distress syndrome caused by respiratory syncytial virus Point-of-care lung ultrasound in young children with respiratory tract infections and wheeze Lung ultrasound: a useful tool in diagnosis and management of bronchiolitis The role of lung ultrasound in viral lower respiratory tract infections Prospective application of clinicianperformed lung ultrasonography during the 2009 H1N1 influenza A pandemic: distinguishing viral from bacterial pneumonia Dynamic assessment of lung injury by ultrasound in a case with H7N9 influenza Early recognition of the 2009 pandemic influenza A (H1N1) pneumonia by chest ultrasound Sonographic detection of radio-occult interstitial lung involvement in measles pneumonitis Variables associated with the early failure of nasal CPAP in very low birth weight infants Reliability of CXR for the diagnosis of bronchopulmonary dysplasia Sonographic prediction of chronic lung disease in the premature undergoing mechanical ventilation The value of ultrasound examination of the lungs in predicting bronchopulmonary dysplasia Chronic pulmonary insufficiency of prematurity: developing optimal endpoints for drug development Prenatal and postnatal management of congenital pulmonary airway malformation Lung ultrasound findings in congenital pulmonary airway malformations BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill Chest ultrasound in acute respiratory distress syndrome Can neonatal lung ultrasound monitor fluid clearance and predict the need of respiratory support? Use of neonatal chest ultrasound to predict noninvasive ventilation failure Lung ultrasound as a predictor of mechanical ventilation in neonates older than 32 weeks Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment Lung ultrasound in the ICU: from diagnostic instrument to respiratory monitoring tool Lung ultrasonography score to evaluate oxygenation and surfactant need in neonates treated with continuous positive airway pressure Point-of-care lung ultrasound in neonatology: classification into Lung ultrasound score predicts surfactant need in extremely preterm neonates Detection of abnormalities in ultrasound lung image using multi-level RVM classification Fetal Lung Texture Team. A prospective international study Clinical data are essential to validate lung ultrasound Diagnosis of neonatal transient tachypnea and its differentiation from respiratory distress syndrome using lung ultrasound Lung ultrasound in respiratory distress syndrome: a useful tool for early diagnosis Diagnostic performance of point of care ultrasonography in identifying the etiology of respiratory distress in neonates Neonatal lung sonography: interobserver agreement between physician interpreters with varying levels of experience Use of lung ultrasound in detection of complications of respiratory distress syndrome Lung ultrasonography of pulmonary complications in preterm infants with respiratory distress syndrome.
    • keywords: absence; accuracy; acute; adult; aeration; air; airway; algorithm; alveolar; analysis; appearance; applications; ards; areas; associated; authors; available; bedside; bpd; bronchiolitis; care; chest; clinical; complications; congenital; consolidations; critical; data; diagnosis; different; diffuse; disease; distress; easy; failure; findings; fluid; functional; high; infants; international; interstitial; life; lines; lung; lung ultrasound; lus; meconium; need; neonatal; neonates; neonatology; newborn; normal; patients; pattern; pleural; pneumonia; pneumothorax; pnx; point; preterm; protocol; pulmonary; quantitative; radiology; research; respiratory; review; safe; score; semiology; severe; signs; specific; studies; study; support; surfactant; syndrome; techniques; tool; transient; ttn; ultrasonography; ultrasound; use; useful
    • versions: original; plain text
16. cord-005774-7z6uyn6p
    • author: Hammer, J.
    • title: Infant lung function testing in the intensive care unit
    • date: 1995
    • words: 5009
    • flesch: 42
    • summary: Although the most fundamental interest in lung volume measurements in infancy and childhood relates to the assessment of normal and abnormal lung growth [47, 48], the determination of lung volumes is an important part of the respiratory management of infants and children [49] . Lung volume measurements can help in diagnosing respiratory disorders, in evaluating responses to therapy, and in finding suitable ventilator settings with respect to rate and ventilating pressures [50-52].
    • keywords: abd; airway; angle; ards; arterial; assessment; bag; bpd; breathing; capacity; care; changes; children; circuit; compliance; concentration; constant; crs; dilution; disease; end; ett; exhalation; flow; frc; function; gas; icu; infants; information; intensive; intubated; loop; lung; management; measurements; mechanical; method; monitoring; new; non; normal; oxygen; passive; patient; phase; physiological; pressure; pulmonary; range; residual; respiratory; response; rrs; single; system; taa; technique; testing; therapy; tidal; time; use; ventilated; ventilation; volume; washout
    • versions: original; plain text
17. cord-005941-e4fvj54l
    • author: Hamm, H.
    • title: The surfactant system of the adult lung: physiology and clinical perspectives
    • date: 1992
    • words: 12905
    • flesch: 35
    • summary: Clq receptor binds other soluble proteins with collagen domains Specific interaction of lung surfactant protein A (SP-A) with rat alveolar macrophages Limitations of using urea to quantify epithelial lining fluid recovered by bronchalveolar lavage Surfactant in adult respiratory distress syndrome Surfactant apoprotein.-A concentration in sputum for diagnosis of pulmonary alveolar proteinosis Sublethal hyperoxic injury to the alveolar epithelium and the pulmonary surfactant system Characterization of antioxidant activities of pulmonary surfactant mixtures Idiopathic pulmonary fibrosis. The role of lung surfactant Role of pulmonary surfactant in the development and treatment of adult respiratory distress syndrome Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity Surface property changes from interactions of albumin with natural surfactant and extracted lung lipids Type II pneumocyte changes during hyperoxic lung injury and recovery Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages Changes in phospholipids in bronchoalveolar lavage fluid of patients with interstitial lung diseases Alterations of acidic phospholipids in bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis Dissolution and reassembly of tubular myelin-like multilamellated structures from the lungs of patients with pulmonary alveolar proteinosis A multicenter, randomized, placebo-controlled trial of surfactant therapy for respiratory distress syndrome Surface and tissue forces, surfactant protein A, and the phospholipid components of pulmonary surfactant in bleomycin-induced pulmonary fibrosis in the rat Changes in phosphatidylglycerol in bronchoalveolar lavage fluids from patients with cryptogenic fibrosing alveolitis Changes of alveolar stability and phospholipids in pulmonary surfactant in acute pancreatitis Surfactant for the treatment of respiratory distress syndrome Surfactant protein B : disulfide bridges, structural properties, and kringle similarities Human alveolar lining material and antibacterial defenses Types of interaction of amphiphilic drugs with phospholipid vesicles Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material Analysis of bronchoalveolar lavage and pulmonary alveolar surfactant for diagnosis of rejection and infection in heart-lung transplantation Alveolar type II cells, surfactant protein A (SP-A), and the phospholipid components of surfactant in acute silicosis in the rat Structure of alveolar epithelial cells in patients with fibrotic lung disorders Fluid dynamics during bronchoalveolar lavage Secretions from primary hamster tracheal surface epithelial cells in culture: mucin-like glycoproteins, proteoglycans, and lipids Isolation of apoproteins from canine surface active material -and pneumonia-induced lung injury.
    • keywords: abnormalities; acid; active; activity; acute; adult; air; alterations; alveolar; alveolar surfactant; alveolar type; analysis; animal; ards; bal; bleomycin; bodies; bronchoalveolar; cells; changes; clinical; complex; components; composition; content; controls; data; days; decrease; defense; different; disease; disorders; distress; dose; dppc; effects; epithelial; evidence; exposure; failure; fatty; fibrosis; findings; fluid; formation; function; future; high; human; ii cells; immune; important; increase; injury; irds; kda; knowledge; known; lamellar; lavage; levels; like; lining; low; lung; lung surfactant; macrophages; major; material; mechanisms; membrane; metabolism; myelin; natural; necessary; nitrogen; number; oxygen; ozone; patients; phosphatidylcholine; phosphatidylglycerol; phospholipids; pneumonia; possible; potential; present; production; properties; protein; pulmonary; pulmonary surfactant; rats; recent; regulation; related; replacement; respiratory; results; review; role; secretion; short; significance; similar; smoke; specific; structural; studies; study; suggest; surface; surfactant; surfactant material; surfactant phospholipids; surfactant protein; surfactant studies; surfactant synthesis; surfactant system; syndrome; synthesis; system; tension; term; therapy; total; toxicity; treatment; trial; tubular; type; type ii; values; ventilation; vitro; vivo; weight; years
    • versions: original; plain text
18. cord-006289-2k8c22u8
    • author: Chu, Shi-Jye
    • title: Systemic Administration of FC-77 Dampens Ischemia–Reperfusion-Induced Acute Lung Injury in Rats
    • date: 2013-06-27
    • words: 4301
    • flesch: 43
    • summary: Role of neutrophil activation Dose-dependent reduction of myocardial infarct size with the perfluorochemical Fluosol-DA Evaluation of lung injury in rats and mice Fructose-1,6-diphosphate attenuates acute lung injury induced by ischemia-reperfusion in rats Baicalin attenuates air embolism-induced acute lung injury in rat isolated lungs Hypercapnic acidosis attenuates reperfusion injury in isolated and perfused rat lungs Neutrophils and acute lung injury Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro Liquid ventilation attenuates pulmonary oxidative damage Neutrophil activation and chemotaxis after in vitro treatment with perfluorocarbon Exposure to perflubron is associated with decreased Syk phosphorylation in human neutrophils Cytokine-mediated inflammation in acute lung injury Tumor necrosis factor-alpha in ischemia and reperfusion injury in rat lungs Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8 Aerosolized perfluorocarbon suppresses early pulmonary inflammatory response in a surfactant-depleted piglet model Intratracheal perfluorocarbons diminish LPS-induced increase in systemic TNF-alpha Perflubron decreases inflammatory cytokine production by human alveolar macrophages Perfluorocarbons decrease Chlamydophila pneumoniaemediated inflammatory responses of rat type II pneumocytes in vitro NF-kappa B activation as a pathological mechanism of septic shock and inflammation Pyrrolidine dithiocarbamate reduces lung reperfusion injury Attenuation of lung reperfusion injury after transplantation using an inhibitor of nuclear factor-kappaB Perflubron reduces lung inflammation in respiratory syncytial virus infection by inhibiting chemokine expression and nuclear factor-kappa B activation Leukocyte antibacterial functions are not impaired by perfluorocarbon exposure in vitro Perfluorocarbon attenuates response of concanavalin A-stimulated mononuclear blood cells without altering ligand-receptor interaction Perfluorohexane attenuates proinflammatory and procoagulatory response of activated monocytes and alveolar macrophages In vitro cellular effects of perfluorochemicals correlate with their lipid solubility Effects of fluosol-DA on brain edema, energy metabolites, and tissue oxygen content in acute cerebral ischemia Perfluorocarbon supplementation and postischemic cardiac function This study was supported, in part, by NSC 98-2314-B-016-034-MY2 from the National Science Council of Taiwan; MAB101-63 from the Ministry of National Defense; grants 10132, 1032, and 10137 from Taoyuan Armed Forces General Hospital; and TSGH-102-066 from Tri-Service General Hospital, Taiwan. Subsequently, bronchoalveolar lavage fluid (BALF), perfusate, and lung tissues were collected to evaluate the degree of lung injury.
    • keywords: acid; activation; activity; acute; administration; alveolar; attenuates; attenuation; blood; cells; concentration; control; control group; decrease; different; effects; fc-77; fig; group; increase; induced; infiltration; inflammation; inflammatory; injury; ir group; ischemia; isolated; liquid; lung; lung injury; min; neutrophil; oxygen; p<0.05; pap; perfluorocarbon; perfusate; permeability; pfcs; pretreatment; production; pulmonary; rat; rats; reperfusion; respiratory; response; results; significant; studies; study; systemic; tissues; tnf; ventilation; weight
    • versions: original; plain text
19. cord-006452-mmdk2xom
    • author: Chen, Jing
    • title: Nucleic Acid-Based Therapeutics for Pulmonary Diseases
    • date: 2018-10-18
    • words: 6615
    • flesch: 28
    • summary: One of the most challenging intracellular barriers for nucleic acids delivery is their tendency to remain entrapped in endosomes. The susceptibility of nucleic acids to degradation and the complex structure of lungs retard the effective pulmonary delivery of nucleic acid drug.
    • keywords: acids; action; activity; acute; administration; aerosol; agents; airway; ali; antisense; aptamers; ards; asos; asthma; barriers; binding; cancer; cells; cellular; cftr; chemical; chronic; clinical; common; complex; copd; current; cystic; degradation; delivery; development; different; diseases; drug; dry; effects; efficiency; enac; expression; family; fda; fibrosis; formulation; function; gene; high; immune; inflammation; inflammatory; inhalation; inhaled; inhibitor; injection; injury; levels; like; lipid; local; lung; lung cancer; micrornas; mirnas; models; modification; molecules; mrna; multiple; murine; muscle; nanoparticles; new; non; novel; nucleic; nucleic acids; obstructive; oligonucleotides; patients; phase; potential; powder; protein; pulmonary; pulmonary diseases; respiratory; responses; route; silencing; sirna; site; small; specific; strand; strategies; study; suppressor; surface; systemic; systems; target; targeted; targeting; therapeutic; therapies; therapy; treatment; trials; tumor; types; vectors; viral
    • versions: original; plain text
20. cord-006541-ror7z8h7
    • author: Liu, Xiaoli
    • title: Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in lung cancer and significant correlations with brain metastasis and natural killer cells
    • date: 2015-07-07
    • words: 4671
    • flesch: 47
    • summary: Global cancer statistics Surfactant protein a suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages Lung cancer: epidemiology, etiology, and prevention Tobacco control policy in developed countries: yesterday, today, and tomorrow Mortality in relation to smoking: 50 years' observations on male British doctors Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 The molecular epidemiology of lung cancer The role of human papilloma virus in lung cancer: a review of the evidence Relationship between Epstein-Barr virus and lymphoepithelioma-like carcinoma of the lung: a clinicopathologic study of 6 cases and review of the literature HIV infection is associated with an increased risk for lung cancer, independent of smoking Soluble selectin levels in patients with lung cancer Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer Cancer of the Lung Selectins as mediators of lung metastasis Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene Mannose-binding lectin-2 genetic variation and stomach cancer risk Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in vivo metastasis to the liver Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in non-Hodgkin lymphoma and significant correlations with lactic acid dehydrogenase and b2-microglobulin Low expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in non-Hodgkin lymphoma and a significant correlation with b2-microglobulin The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR: subunit organization and binding to multivalent ligands DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection Homozygous L-SIGN (CLEC4 M) plays a protective role in SARS coronavirus infection DC-SIGN and L-SIGN: the SIGNs for infection Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor The new World Health Organization classification of lung tumours The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours The elderly with synchronous non-small cell lung cancer and solitary brain metastasis: does palliative thoracic radiotherapy have a useful role A cancer stem cell model for studying brain metastases from primary lung cancer The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives Trial design on prophylaxis and treatment of brain metastases: lessons learned from the EORTC Brain Metastases Strategic Meeting S100B protein as a possible participant in the brain metastasis of NSCLC S100B promotes the proliferation, migration and invasion of specific brain metastatic lung adenocarcinoma cell line ProApolipoprotein A1: a serum marker of brain metastases in lung cancer patients Serum S100b as a possible marker of blood-brain barrier disruption Functions of natural killer cells Natural killer cells in human cancer: from biological functions to clinical applications Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population Prognostic value of intratumoral natural killer cells in gastric carcinoma The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer The prognostic value of natural killer cell infiltration in resected pulmonary adenocarcinoma Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1 DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis Acknowledgments This study was supported by grants from the Chinese National Natural Science Foundation Projects (81372669,31270867, 31470800) and Science and Technology Planning Project of Liaoning province, China (2012225020). Results showed that serum DC-SIGNR levels in lung cancer patients were lower than that in healthy controls (P = 0.0003).
    • keywords: anti; brain; cancer; cancer patients; carcinoma; cells; clinical; coefficient; concentrations; controls; correlation; density; difference; endothelial; expression; fig; groups; healthy; higher; human; infection; killer; levels; lower; lung; lung cancer; lung tissues; lymph; mean; metastasis; molecular; natural; negative; non; normal; p =; patients; plates; present; protein; results; risk; role; s100b; serum; serum dc; serum levels; significant; signr; signr expression; signr levels; spearman; stage; study; supplementary; tissues; tuberculosis; tumor; virus; years
    • versions: original; plain text
21. cord-006605-tsk3pakb
    • author: Jesmin, Subrina
    • title: Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury
    • date: 2006-11-30
    • words: 4514
    • flesch: 40
    • summary: key: cord-006605-tsk3pakb authors: Jesmin, Subrina; Gando, Satoshi; Zaedi, Sohel; Sakuraya, Fumika title: Differential Expression, Time Course and Distribution of Four PARs in Rats with Endotoxin-induced Acute Lung Injury date: 2006-11-30 journal: Inflammation DOI: 10.1007/s10753-006-9017-8 sha: doc_id: 6605 cord_uid: tsk3pakb The hypothesis that the expression of protease-activated receptors (PARs) protein is regulated at the level of transcription and that PAR isoforms, PAR-1, PAR-2, PAR-3, and PAR-4, in lung tissue show different patterns of expression in lipopolysaccharide (LPS)-induced acute lung injury (ALI) was tested. We examined the expression of protein and mRNA and the immunohistochemical localization of PAR isoforms in lung tissues 1, 3, 6, and 10 h after LPS administration.
    • keywords: activation; acute; addition; administration; ali; alveolar; anti; antibodies; antibody; blood; cells; coagulation; control; deposition; distinct; distribution; endothelium; epithelium; expression; factor; fibrin; fig; human; immunoreactivity; increase; induced; inflammation; injury; isoforms; levels; lps; lps administration; lung; macrophages; mouse; muscle; par; par-2; pars; pathogenesis; present; protease; protein; pulmonary; rats; receptors; role; sections; similar; sized; smooth; staining; strong; study; thrombin; time; tissue; tnf; transcription; vascular; vessels
    • versions: original; plain text
22. cord-006624-or0cpc6j
    • author: Kamler, M.
    • title: Aktueller Stand der Lungentransplantation: Pulmonale und nichtpulmonale Komplikationen
    • date: 2013-05-31
    • words: 3270
    • flesch: 33
    • summary: Das primäre Organversagen ( primary graft dysfunction, PGD) ist mit einer Inzidenz zwischen 14 und 23% weiterhin eine bedeutsame Komplikation in der perioperativen Phase der Lungentransplantation [7] . Da bei der Lungentransplantation mit der Durchführung der bronchialen Anastomosen formal in einem unsterilen Bereich gearbeitet wird, kommt es häufiger zu Infektionen als bei Transplantationen anderer Organe.
    • keywords: aber; abstoßung; acute; adult; advanced; airway; akuten; allograft; als; analyse; andere; antikörper; applikation; aspiration; auch; auf; aus; azithromycin; bal; bei; besteht; bis; bos; bronchiolitis; cmv; complications; dabei; das; dass; dem; der; des; diagnose; die; diese; disease; durch; dysfunction; early; einer; end; entwicklung; faktoren; fokus; führen; für; gastroesophageal; geht; gerd; gibt; glycation; graft; hat; heart; histologisch; hla; human; häufigsten; immunsuppressiva; impact; infektionen; insbesondere; international; ist; jahr; kann; kommt; komplikationen; konnte; können; lars; letalität; leukocyte; lung; lungenfunktion; lungenschädigung; lungentransplantation; lungentransplantierten; missmatch; mit; mithilfe; nach; neben; nicht; nichtpulmonale; noch; non; nur; obliterans; oder; organversagen; patienten; patients; pepsin; perioperativen; pgd; postoperativen; primary; products; prophylaxe; pulmonary; rahmen; receptor; reflux; rejection; respiratory; retrospektiven; risiko; sich; sie; significant; sind; society; sowie; studie; survival; therapie; transplantation; treatment; und; vergesellschaftet; von; weitere; werden; wie; wird; zahl; zeigen; zum; zur; zwischen; über
    • versions: original; plain text
23. cord-006653-fy0yg0xh
    • author: Popper, Helmut H.
    • title: Interstitial lung diseases—can pathologists arrive at an etiology-based diagnosis? A critical update
    • date: 2012-12-07
    • words: 13645
    • flesch: 36
    • summary: key: cord-006653-fy0yg0xh authors: Popper, Helmut H. title: Interstitial lung diseases—can pathologists arrive at an etiology-based diagnosis? Interstitial lung diseases (ILD) are characterized by a diffuse infiltration of both lungs, usually evaluated by highresolution computed tomography (HRCT) scan.
    • keywords: accumulation; acute; addition; affected; allergic; alveolar; alveoli; amyloid; areas; arthritis; autoantibodies; autoimmune; balt; blood; bodies; body; bronchioles; bronchiolitis; cases; cause; cells; changes; children; chronic; classification; clinical; collagen; common; complexes; contrast; cvd; cystic; dad; damage; death; deposition; diagnosis; different; diffuse; disease; drug; early; endothelial; eosinophilic; epithelial; etiology; expression; features; fibroblastic; fibrosing; fibrosis; fibrotic; fig; findings; foci; focus; form; formation; function; gene; genetic; giant; granulation; granulomas; hard; hemorrhage; high; histiocytosis; hrct; hyaline; hyperplasia; idiopathic; idiopathic pulmonary; induced; infection; infiltrates; infiltration; inflammatory; inhalation; interstitial; interstitial fibrosis; interstitial lung; interstitial pneumonia; involvement; ipf; langerhans; large; later; lesions; lhch; like; lip; lobules; lung; lung disease; lupus; lymphangioleiomyomatosis; lymphocytic; macrophages; major; material; membranes; metabolic; metal; microlithiasis; morphologic; mutations; new; nonspecific; nsip; organizing; pathogenesis; pathologic; pathologists; patients; pattern; peripheral; phase; picture; pneumocytes; pneumonia; pneumonitis; positive; present; proliferation; proteinosis; proteins; pulmonary; pulmonary fibrosis; rare; reactions; resolution; respiratory; results; review; rheumatoid; sclerosis; septa; severe; single; sjs; sjøgren; sle; small; smokers; smoking; specific; ssc; stages; study; suppl; surfactant; symptoms; syndrome; systemic; therapy; tissue; toxic; treatment; tumor; type; uip; underlying; usual; variety; viral; virus; walls
    • versions: original; plain text
24. cord-006676-a21tdgns
    • author: Abul, H.
    • title: Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients
    • date: 2001
    • words: 3628
    • flesch: 44
    • summary: Since alveolar macrophages are the major source of IL-8 in the lung, the local production of IL-8 by these cells may be responsible for the recruitment of PMNs into the pulmonary interstitial or air space in a variety of lung diseases. Recent reports have considered IL-8 as the most potent and major PMN chemoattractant factor in lung diseases [13]
    • keywords: accumulation; activity; asthma; bacterial; bal; bals; cells; chemoattractant; chemotactic; concentrations; control; diseases; enzyme; eosinophils; factors; fluid; granules; group; human; il-8; increase; infected; infected lung; inflammation; inflammatory; interleukin-8; involvement; lavage; level; lung; major; min; mpo; mrna; myeloperoxidase; neutrophils; non; patients; pcr; pmns; pneumonia; potent; present; production; protein; release; respiratory; results; role; specific; studies; study; syndrome; total; type; vivo
    • versions: original; plain text
25. cord-006700-df8ard9o
    • author: Müller-Redetzky, Holger C.
    • title: Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives
    • date: 2014-03-06
    • words: 10653
    • flesch: 18
    • summary: For example, cell wall peptidoglycan of Streptococcus pneumoniae activates TLR-2 (Schroder et al. 2003) , while the pneumococcal exotoxin pneumolysin is recognized by TLR-4 and NLRP-3 (Malley et al. 2003; Witzenrath et al. 2011) . Pneumolysin, for example, may rapidly induce (1) Ca 2+ influx and (2) liberation of platelet activating factor (PAF) followed by thromboxane release (Lucas et al. 2012; Witzenrath et al. 2007 ).
    • keywords: actin; activation; activity; acute; acute lung; addition; adhesion; adrenomedullin; alpha; alveolar; ards; bacterial; barrier; blocking; blood; c3a; c5a; cadherin; cascades; cells; cellular; central; ceramide; clinical; coagulation; complement; complex; concentrations; contraction; dependent; development; different; disease; disruption; distress; dysfunction; ecs; effects; endothelial; endothelial barrier; endothelial cells; endothelial permeability; endotoxin; epithelial; et al; experimental; expression; extracellular; factor; failure; formation; fty720; function; generation; high; human; hyperpermeability; imatinib; immune; important; increase; infection; inflammation; inflammatory; inhaled; inhibition; injury; innate; integrity; ischemia; junctions; kinase; leading; leads; leakage; leukocyte; levels; like; lps; lung; lung injury; mechanical; mechanisms; mediates; mediators; mice; microvascular; mlck; models; molecules; monocytes; mortality; murine; myosin; neutrophils; nitric; oedema; oxide; oxygen; paf; paracellular; pathway; patients; permeability; phosphate; phosphorylation; plasma; platelets; pneumolysin; pneumonia; potential; production; protein; pulmonary; reactive; receptor; recruitment; reduced; regulation; related; release; reperfusion; respiratory; response; rhoa; rns; role; ros; s1p; s1p1; sepsis; severe; signaling; soluble; species; specific; sphingosine; staphylococcus; stimulation; stress; studies; suttorp; syndrome; systemic; therapeutic; thrombin; thromboxane; tie2; tlr4; tnf; toll; treatment; vascular; vascular permeability; ventilator; vitro; vivo
    • versions: original; plain text
26. cord-006760-mgrxo21j
    • author: Lee, James C.
    • title: Critical care management of the lung transplant recipient
    • date: 2012-06-22
    • words: 5046
    • flesch: 29
    • summary: Given the severity of illness of such patients at the time of surgery, lung transplant recipients require particular attention in the immediate post-operative period to ensure optimal short-term and long-term outcomes. Causes and treatment of conditions affecting early morbidity and mortality in lung transplant recipients will be detailed, including primary graft dysfunction, cardiovascular and surgical complications, and immunologic and infectious issues.
    • keywords: active; aggressive; allograft; arterial; atrial; bleeding; blood; bridge; bronchial; care; case; centers; chest; complications; critical; cultures; cystic; diseases; donor; dysfunction; early; ecmo; experience; extended; extracorporeal; factors; failure; fibrosis; graft; group; heart; high; hyperacute; icu; ill; immediate; infectious; intra; issues; long; lung; lung transplantation; management; mechanical; membrane; morbidity; mortality; operative; organ; outcomes; oxygenation; patients; period; pgd; post; potential; pre; primary; procedure; pulmonary; rates; recipient; rejection; renal; respiratory; right; risk; severe; significant; single; state; support; surgical; survival; term; therapy; time; transplant; transplant recipient; transplantation; treatment; use; ventilation; ventilatory; year
    • versions: original; plain text
27. cord-006862-5va1yyit
    • author: None
    • title: ITS ASM 2012
    • date: 2012-11-04
    • words: 26008
    • flesch: 50
    • summary: A questionnaire was sent to relevant members of the Exercise has been shown to improve quality of life in respiratory patients. Conclusion: A significant percentage of respiratory patients lack adequate knowledge of their respiratory medication; this is despite a majority having previously been educated on this medication.
    • keywords: aat; aatd; access; activity; acute; adherence; admission; age; ahi; aim; airway; alcohol; alpha-1; analysis; antibiotics; antitrypsin; apnoea; appropriate; arterial; assessment; associated; asthma; audit; background; bal; baseline; bilateral; biopsy; blood; bmi; breath; bronchial; bronchiectasis; bronchoscopy; cancer; capacity; care; cases; cause; cells; cessation; change; chest; children; chronic; clinical; cohort; common; complete; complications; conclusion; conditions; consistent; consolidation; control; copd; copd patients; cork; correlation; cough; ctpa; culture; curb-65; current; cxcr3; cxr; cystic; data; date; days; deficiency; department; development; diagnosis; difference; disease; disease patients; dose; dyspnoea; early; ebus; education; effusions; elevated; evidence; exacerbations; examination; exercise; experience; expression; factors; failure; female; fev1; fibrosis; findings; fluid; follow; free; function; general; gentleman; group; guidelines; haemoptysis; healthy; high; higher; history; hold; hospital; idiopathic; ild; imaging; important; improved; increase; individuals; infection; inflammation; inflammatory; inhaler; inhibitors; initial; international; interstitial; invasive; ipf; ipf patients; ireland; irish; key; knowledge; large; lavage; left; length; lesion; levels; life; liver; lobe; long; lower; lung; lung cancer; lung disease; lymphoma; male; management; mass; mean; mean age; medical; methods; mif; min; months; mortality; mtb; multiple; muscle; mutation; mycobacterium; n =; need; negative; neutrophil; new; non; normal; novel; number; observed; obstruction; old; onset; oral; osas; outcomes; oxygen; p =; parents; patients; pcd; period; persistent; physical; pirfenidone; pizz; plasma; pleural; pneumonia; poor; population; positive; post; predictive; prescribed; prescription; presence; present; presentation; prevalence; primary; prior; procedure; program; programme; progressive; protein; pulmonary; pulmonary disease; quality; questionnaire; radiological; range; rare; rate; recurrent; reduction; reported; research; resection; resolution; respiratory; respiratory disease; response; results; retrospective; review; right; risk; role; samples; sarcoidosis; score; secondary; sensitivity; serum; service; severe; severity; significant; sleep; small; smokers; smoking; spirometry; sputum; stable; stage; standard; steroids; studies; study; subjects; subsequent; survival; swa; symptomatic; symptoms; syndrome; tbna; technique; term; testing; tests; therapeutic; therapy; thorax; time; tissue; tnf; total; treatment; trial; tst; tuberculosis; tumour; type; ultrasound; underwent; university; upper; use; value; vats; ventilation; wall; weaning; weeks; western; wheeze; year old; years
    • versions: original; plain text
28. cord-006888-qfnukav4
    • author: None
    • title: Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008
    • date: 2008-10-21
    • words: 30386
    • flesch: 51
    • summary: We determined the frequency of HSV-1 in COPD patients (stable and exacerbated) and if it was associated with disease severity and mortality. Methods: Stable and exacerbated COPD patients were recruited.
    • keywords: a1at; aat; aatd; ability; abnormal; access; active; activities; activity; acute; adenosine; admissions; aecopd; aeruginosa; age; ahi; aim; airway; alpha-1; analysis; antibiotic; antibody; anxiety; appropriate; assessment; associated; asthma; asthmatic; audit; available; average; bacterial; ban; baseline; belfast; beta; biopsy; blood; bmi; body; bronchial; bronchiectasis; bronchoscopy; bts; cancer; capacity; cardiac; care; cases; cause; cells; cf patients; changes; chest; children; chronic; clinical; cohort; combination; common; community; compliance; conclusion; conditions; confirmed; control; copd; copd patients; correlation; cough; cpap; cpet; criteria; crp; cse; culture; current; cystic; data; days; death; decrease; deficiency; dependent; development; diabetic; diagnosis; differences; disease; dose; drains; drug; duration; early; education; effect; effective; elevated; endurance; eosinophil; epithelial; eus; evidence; exacerbations; exercise; experience; exposure; expression; factors; failure; female; fev1; fibrosis; findings; fna; following; free; function; general; group; guidelines; health; high; higher; highlights; history; home; hospital; hypertonic; igg; il-8; impact; important; improved; incidence; increased; index; individuals; induced; infection; inflammation; inflammatory; information; inhaled; initial; injury; international; intervention; interviews; invasive; involvement; ipf; ireland; irish; isolates; issues; knowledge; known; large; levels; life; limited; liver; living; ll-37; long; lower; lpa; lps; lung; lung cancer; macrophages; major; male; management; mass; mds; mean; measure; median; medical; membrane; methods; months; morbidity; mortality; muscle; n =; national; need; negative; neutrophil; niv; non; normal; number; nurse; obstructive; old; omalizumab; osa; osas; outcome; outpatient; overall; oxygen; p =; pack; palliative; pathway; patients; pcr; period; players; pleural; pneumonia; poor; population; positive; post; potential; practice; prescribed; presence; present; pressure; prevalence; primary; prior; procedure; programme; prophylaxis; protein; pulmonary; quality; questionnaire; radiation; range; rate; receptor; recurrent; reduction; referrals; regulation; rehabilitation; related; release; report; research; resistant; respiratory; response; results; retrospective; review; risk; role; s1p; saline; samples; sarcoidosis; score; screening; second; serum; service; severe; severity; shr; shuttle; significant; similar; sleep; slpi; small; smokers; smoking; society; specialist; spirometry; sputum; stable; staging; standard; status; stay; strategy; studies; study; subjects; support; surgical; survey; symptoms; syndrome; system; tbna; term; test; testing; therapy; thoracic; time; tlc; total; treatment; tuberculosis; type; ultrasound; underwent; unit; use; vitamin; ward; weeks; western; years
    • versions: original; plain text
29. cord-006924-1i3kf01j
    • author: None
    • title: Abstracts from USCAP 2020: Pulmonary, Mediastinum, Pleura, and Peritoneum Pathology (1869-1980)
    • date: 2020-03-05
    • words: 25402
    • flesch: 47
    • summary: We reviewed lung cases with eosinophilic deposits and immune infiltrates with negative Congo Red stain. Background: Molecular targeted therapies against EGFR and ALK have improved the quality of life of lung adenocarcinoma patients.
    • keywords: absence; accuracy; additional; adenocarcinoma; alk; alterations; alveolar; analysis; assay; assessment; associated; association; available; average; background; bal; bap1; benign; biomarker; biopsies; biopsy; blocks; cancer; carcinoid; carcinomas; cases; cdx2; cell; cell lung; cellular; characteristics; characterized; ck7; classic; classification; clinical; clinicopathological; clone; cohort; combined; common; component; conclusions; confirmed; correlation; crcs; criteria; ctnnb1; cytology; data; days; death; deposits; design; diagnosis; differences; different; diffuse; disease; egfr; epithelioid; epithelium; exon; expression; factors; features; ffpe; figure; findings; fish; focal; foci; following; free; frequent; gdtl; gene; generation; genetic; genomic; germline; gnas; grade; group; growth; heterogeneity; high; high expression; high pd; higher; histologic; history; hospital; ihc; ild; images; imas; immune; immunohistochemistry; immunotherapy; important; independent; inflammation; insertion; insm1; interstitial; invasive; italy; ki67; kras; l1 expression; lam; large; lcdd; lcnec; lesions; levels; light; like; likely; loss; low; lower; lung; lung adenocarcinoma; lung cancer; lymph; malignant; markers; mean; median; medical; melanomas; mesothelioma; metastases; metastatic; method; micro; mitotic; mms; model; molecular; morphology; msla; mtap; mucinous; multiple; mutant; mutations; myxoid; necrosis; negative; neuroendocrine; ngs; nodular; non; normal; novel; nsclc; nuclear; number; overall; p16; p<0.001; p<0.05; pairs; panel; pathologists; patients; pattern; pcr; pd-1; pd1; pea; percentage; pkm2; platform; pmas; positive; potential; predictive; predominant; presence; present; primary; primary lung; prognosis; progression; proliferation; pulmonary; radiological; range; rapid; rare; rate; report; resection; resistance; response; results; review; role; ros1; samples; sarcomatoid; satb2; score; sections; sensitivity; sequencing; short; shorter; significant; similar; single; site; size; slides; small; smarca4; smoking; solid; specific; specificity; specimens; sputum; squamous; stage; staining; stas; status; studies; study; subset; subtype; surgical; survival; table; targeted; telomeres; testing; tests; therapy; thymic; time; tissue; total; transformation; treatment; ttf-1; tumor; type; uip; value; variants; vegf; villin; wild; worse; years
    • versions: original; plain text
30. cord-008510-mnpu27kl
    • author: Lipscomb, Mary F.
    • title: The Regulation of Pulmonary Immunity
    • date: 2008-04-10
    • words: 30224
    • flesch: 29
    • summary: Demonstration that lung cells regulate both nonspecific inflammation and immunity through the expression of adhesion molecules and the secretion of cytokines offers hope for ways to design more effective vaccines, enhance microbial clearance in immune-suppressed hosts, and to suppress manifestations of immunologically mediated lung disease. Lung macrophages are the most difficult cells to separate from DCs in single cell suspensions of lung cells.
    • keywords: ability; accessory; accumulation; activation; activity; acute; acute lung; addition; adhesion; administration; adoptive; aerosol; afcs; airway; allergic; allograft; alveolar; alveolar macrophages; alveoli; ams; animals; antibodies; antibody; antigen; apc; apcs; appropriate; areas; associated; asthma; b cells; bal; balt; bice et; binding; bleomycin; blood; bone; bronchial; bronchioles; bronchoalveolar; capable; capacity; cd4; cd4 cells; cd4 t; cd8; cells; central; challenge; changes; characterization; chronic; class; clearance; cmi; cne; common; complement; complex; concept; contrast; control; cryptococcus; cyclosporin; cytokines; data; days; dcs; defense; dendritic; dendritic cells; dependent; depletion; development; differences; different; direct; disease; dogs; dth; early; effective; effector; effects; enhanced; epithelium; et al; evidence; example; experimental; exposure; expression; factor; fcr; fibrosis; fluid; free; function; growth; guinea; gvhd; hapten; high; holt; host; huffnagle et; human; human lung; humoral; hypersensitivity; ifny; iga; igg; il-2; il-4; immune; immune cells; immune response; immune t; immunity; immunization; immunized; immunoglobulin; immunologic; important; increase; induced; induction; infected; infection; infiltration; inflammation; inflammatory; influenza; inhibition; initial; injury; inoculation; instillation; interaction; interstitial; intracellular; intraepithelial; intranasal; intratracheal; isolated; kaltreider; lalns; large; lavage; lead; lesions; levels; likely; lipscomb; lipscomb et; live; lobes; local; long; lower; lung; lung allograft; lung cells; lung dcs; lung disease; lung immunity; lung immunization; lung infections; lung injury; lung lobes; lung lymphocytes; lung macrophages; lung t; lung transplantation; lymphocytes; lymphoid; macrophages; major; marrow; mechanisms; memory; memory t; mhc; mice; migration; model; molecules; monocytes; mononuclear; mouse; mrna; mtb; mucosal; mulligan et; murine; mycobacterium; naive; natural; necrosis; neoformans; neutrophils; nodes; nonspecific; normal; numbers; organisms; ova; parenchyma; particles; particulate; pathogenesis; pathology; peripheral; perivascular; phase; phenotype; pigs; piguet et; pneumococcal; pneumoniae; pneumonitis; populations; possible; presence; present; primary; process; production; prop et; protective; protein; pulmonary; pulmonary immune; pulmonary infection; rabbits; rat lung; rats; recent; receptors; recipient; recruitment; regulation; rejection; relationship; relative; release; relevant; resident; resistance; respiratory; response; responsible; results; role; schuyler; secretion; sensitization; sensitized; serum; similar; sites; skin; soluble; spaces; species; specific; spleen; stein; stimulation; strain; streilein et; streptococcus; structures; studies; study; subsets; surface; systemic; t cells; t h; term; th2; tissue; tnfa; tract; transfer; transplantation; tuberculosis; tumor; type; upper; vaccination; vaccine; van; viral; virulent; virus; viruses; wilkes; y6 t; yousem; yousem et
    • versions: original; plain text
31. cord-009764-m9flptcv
    • author: Bossé, Ynuk
    • title: The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity
    • date: 2019-01-18
    • words: 15772
    • flesch: 52
    • summary: They are also unable to distinguish between radial versus longitudinal airway strain. Since ASM is embedded within the airway wall in an orientation that is nearly orthogonal to the long axis of the airways [97, 98] , an increase in airway caliber necessarily implies that ASM is transiently elongated.
    • keywords: acoustic; airflow; airway; airway caliber; airway distensibility; airway resistance; airway smooth; airway strain; airway tree; airway wall; area; asm; asm strain; asthma; asthmatic; axis; biological; body; breathing; bronchi; bronchial; bronchodilator; capacity; case; change; compliance; confounders; contractile; contractility; copd; cross; curve; deep; deflation; different; different lung; dynamic; effect; example; excursion; extent; fact; flow; forced; fot; frc; frequencies; geometry; greater; healthy; high; hrct; human; hysteresis; important; increase; induced; inflation; inspiration; isolated; large; length; level; likely; limitations; long; lumen; luminal; lung; lung volume; maneuvers; measurements; mechanics; methacholine; methods; mouth; muscle; oscillation; p l; parenchyma; patients; perimeter; pitot; pleth; pressure; probe; radius; range; raw; reflection; relationship; relative; reported; resistance; resolution; respiratory; response; review; rrs; sectional; single; size; small; smooth muscle; static; strains; stretch; studies; study; subjects; table; technique; tidal; time; tlc; tomography; total; tracheal; transmural; undergoes; vitro; vivo; volume; wall strain
    • versions: original; plain text
32. cord-009766-mdmqcvww
    • author: Comerford, Andrew
    • title: Structured Tree Impedance Outflow Boundary Conditions for 3D Lung Simulations
    • date: 2010-08-01
    • words: 6335
    • flesch: 42
    • summary: ͓17,21͔ included for the first time the effects of fluid-structure interaction ͑FSI͒. There has been considerable work in the area of lung impedance, specifically related to 1D transmission line models ͓22-25͔. Impedance of the lung is an extremely important phenomenon as it plays a central role in the development and distribution of lung disease. The simulations are performed under a variety of conditions such as light breathing and constant flow ventilation (which is characterized by very rapid acceleration and deceleration).
    • keywords: 3d domain; acceleration; acute; addition; airways; alveolar; approach; area; boundary; boundary conditions; breathing; bronchial; change; conditions; constant; coupling; different; diseased; distress; distribution; domain; downstream; drop; dynamics; effects; fig; flow; flowrate; fluid; free; generations; geometry; higher; human; impedance; impedance conditions; important; left; level; lobe; lower; lung; lung tree; mean; mechanical; mechanical ventilation; method; model; modeling; normal; number; observed; order; outflow; outlet; particular; peripheral; phase; pressure; pressure distribution; profile; region; relationship; respiratory; results; right; similar; simulations; small; structured; superior; syndrome; time; tracheobronchial; traction; tree; upper; ventilation; vessels; wall
    • versions: original; plain text
33. cord-009774-tqhexzdp
    • author: Neyman, Greg
    • title: A Single Ventilator for Multiple Simulated Patients to Meet Disaster Surge
    • date: 2008-06-28
    • words: 1834
    • flesch: 43
    • summary: Although larger urban hospitals may be able to justify the resources to stockpile disposable ventilators, smaller hospitals may not. In the event of a need for more ventilators than are currently available in a hospital, it may be valuable to explore methods to maximally utilize the ventilators that are already available.
    • keywords: available; capacity; circuit; configuration; control; disaster; hospitals; hours; individual; lung; min; number; operation; oxygen; patients; potential; pressure; respiratory; simulators; single; study; support; surge; system; test; tidal; total; tubing; ventilator; volume
    • versions: original; plain text
34. cord-009983-naht0ik6
    • author: Kim, Yoon Hee
    • title: Transforming growth factor‐beta 1 in humidifier disinfectant‐associated children's interstitial lung disease
    • date: 2015-06-25
    • words: 4457
    • flesch: 39
    • summary: Epidemic acute interstitial pneumonia in children occurred during the early Nationwide surveillance of acute interstitial pneumonia in Korea Toxic inhalational injury-associated interstitial lung disease in children Two series of familial cases with unclassified interstitial pneumonia with fibrosis Interim report of epidemiological investigation on lung injury with unknown cause in Korea Fatal misuse of humidifier disinfectants in Korea: importance of screening risk assessment and implications for management of chemicals in consumer products Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice Humidifier lung: possible contribution of endotoxin-induced lung injury Altered pulmonary defense system in lung injury induced by didecyldimethylammonium chloride in mice Inhalation toxicity of humidifier disinfectants as a risk factor of children's interstitial lung disease in Korea: a case-control study Humidifier disinfectantassociated children's interstitial lung disease Paediatric interstitial lung disease: classification and definitions An official American thoracic society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy An official American thoracic society/European respiratory society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias Year in review 2012: acute lung injury, interstitial lung diseases, sleep and physiology Interstitial lung disease IPF: new insight on pathogenesis and treatment Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis Significance of serum vascular endothelial growth factor level in patients with idiopathic pulmonary fibrosis Circulating KL-6 predicts the outcome of rapidly progressive idiopathic pulmonary fibrosis Re-evaluation of fibrogenic cytokines in lung fibrosis A role for MCP-1/CCR2 in interstitial lung disease in children Modern concepts on the role of inflammation in pulmonary fibrosis Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data TGF-beta signaling promotes survival and repair in rat alveolar epithelial type 2 cells during recovery after hyperoxic injury Developmental responses to lung injury: repair or fibrosis It has been identified as a reliable index in IPF, reflecting the degree of lung fibrosis on radiologic imaging and the severity of the disease.
    • keywords: abrupt; acute; adjusted; admission; alveolar; beta; changes; children; clinical; control; course; cytokines; data; decrease; disease; disinfectants; endothelial; excessive; factor; fibrosis; findings; growth; humidifier; idiopathic; inflammation; injury; interstitial; kim; korea; laboratory; lung; model; non; pao; pathologic; patients; prognostic; pulmonary; related; repair; respiratory; results; role; serial; serum; slope; study; survival; survivors; table; tgf; time; treatment; trends; values; vascular; vegf
    • versions: original; plain text
35. cord-010078-8lkkez3n
    • author: None
    • title: Invited Speakers
    • date: 2010-11-24
    • words: 21364
    • flesch: 41
    • summary: The SIRT1 is decreased in alveolar macrophages of smokers and COPD patients, and associated with pro-infl ammatory response through the activation of NF-κB. Understanding the complexity of infl ammatory and epigenetic regulations in chronic lung diseases may potentiate the development of novel therapies. In China, non-smokers accounted for 38.6% of COPD patients compared with 24.9% in USA and 22.9% in the UK.
    • keywords: abnormalities; activity; acute; addition; adults; advances; airway; altitude; alveolar; ammation; ammatory; ams; analysis; antibiotics; antibody; approaches; ards; asbestos; asian; assessment; asthma; available; benefi; benign; better; biomarkers; biopsy; blood; bmi; body; bronchitis; bronchoscopy; brosis; burden; cacy; cancer; capacity; care; cases; cation; cause; cells; cellular; certain; cessation; chemotherapy; chest; children; chronic; chronic obstructive; classifi; clinical; clinicians; combination; common; compartment; confi; control; copd; copd patients; corticosteroids; cough; countries; cpap; crd; current; cvd; data; days; decline; decrease; defi; development; diagnosis; differences; different; diffi; disease; disorders; drug; early; edema; effective; effects; effi; effusions; egfr; emphysema; environmental; epithelial; evidence; exacerbations; exercise; exible; exposure; factors; failure; feno; fev1; frequent; function; future; gefi; gene; genetic; gina; gold; greater; group; growth; guidelines; hape; health; heart; high; history; hospital; hrct; hypertension; identifi; idiopathic; iips; ild; image; imaging; implementation; important; increased; individuals; induced; infection; infl; inhaled; initial; international; interstitial; interventions; journal; large; leptin; lesions; levels; life; light; likely; limited; long; low; lower; lung; lung cancer; lung disease; lung function; major; malignant; management; mechanisms; medical; medications; mesothelioma; methods; middle; mild; modifi; mortality; multiple; muscle; mutations; national; ndings; ned; need; new; non; normal; novel; number; obstructive; obstructive pulmonary; outcomes; oxygen; pacifi; pah; pathogenesis; patients; people; phenotypes; physicians; pleural; pneumonia; poor; population; potential; practice; presence; present; pressure; prevalence; prevention; previous; process; production; program; public; pulmonary; pulmonary disease; rate; recent; receptor; recognition; reduced; rehabilitation; remodeling; respiratory; respirology; responses; results; rigid; risk; role; rst; screening; sdb; second; severe; severity; signifi; similar; sleep; small; smoke; smokers; smoking; society; specifi; spirometry; sputum; stage; standard; strategies; studies; study; subjects; support; survival; susceptibility; symptoms; syndrome; system; systemic; techniques; term; test; therapeutic; therapies; therapy; thoracic; time; tinib; tiotropium; tissue; titration; tobacco; travel; treatment; trials; tumors; underlying; understanding; use; useful; vascular; vivo; vte; wall; weight; world; years
    • versions: original; plain text
36. cord-010994-1ynel55w
    • author: Abe, Kyoko
    • title: Nicorandil, a K(ATP) Channel Opener, Attenuates Ischemia–Reperfusion Injury in Isolated Rat Lungs
    • date: 2020-02-21
    • words: 3611
    • flesch: 53
    • summary: However, the underlying mechanisms, especially how and where endothelial cells are impaired during and after IR lung injury, remain unclear. Although the protective effects of nicorandil on IR injury may be because of its K ATP channel opener properties [5] , its effects on microvascular permeability both during and after IR lung injury have yet to be evaluated.
    • keywords: activation; administration; atp; baseline; cgmp; channel; effects; endothelial; glibenclamide; group; increase; injury; ir group; ischemia; isolated; kfc; lung; microvascular; min; mmhg; nicorandil; odq; opener; perfusate; perfused; permeability; present; pressure; protective; pulmonary; rat; reperfusion; sgc; sham; significant; study; venous; weight
    • versions: original; plain text
37. cord-011337-cyku17s8
    • author: Hsu, Fushun
    • title: Locating stridor caused by tumor compression by using a multichannel electronic stethoscope: a case report
    • date: 2020-05-09
    • words: 3519
    • flesch: 47
    • summary: Fundamentals of lung auscultation Auscultation of the respiratory system Automatic adventitious respiratory sound analysis: a systematic review Real-world evaluation of the Eko electronic teleauscultation system Inter-rater agreement of auscultation, palpable fremitus, and ventilator waveform sawtooth patterns between clinicians Wheeze detection in the pediatric intensive care unit: comparison among physician, nurses, respiratory therapists, and a computerized respiratory sound monitor Computerized lung sound analysis as diagnostic aid for the detection of abnormal lung sounds: a systematic review and meta-analysis A survey of sound source localization methods in wireless acoustic sensor networks Energy-based acoustic source localization methods: a survey Acoustic imaging of the human chest Localizing lung sounds: Eigen basis decomposition for localizing sources within a circular array of sensors Sound localization in the human thorax Boundary element model for simulating sound propagation and source localization within the lungs Localization of adventitious respiratory sounds Acoustic mapping of the lung based on source localization of adventitious respiratory sound components Adventitious lung sounds imaging by ICA-TVAR scheme Energy-based collaborative source localization using acoustic microsensor array Medical image segmentation using 3D seeded region growing Understanding the meaning of accuracy, trueness and precision Computed tomography: principles, design, artifacts, and Adventitious lung sound localization is potentially beneficial in diagnosing pulmonary diseases because the location of the sound source can indicate the anatomical region that is most likely affected.
    • keywords: acoustic; admission; adventitious; airway; analysis; area; auscultation; bronchial; bronchoscopy; bronchus; case; center; chest; compression; deviation; electronic; energy; fig; frequency; ith; left; lingular; localization; location; lung; mean; medical; method; model; multichannel; orifice; patient; pulmonary; radial; radius; red; region; report; respiratory; rois; second; sensor; signals; sound; sound source; source; source localization; standard; stethoscope; stridor; study; system; time; tumor; upper; value; visual
    • versions: original; plain text
38. cord-011345-w0ke1tqz
    • author: Howe, Sarah L.
    • title: Measuring lung mechanics of expiratory tidal breathing with non-invasive breath occlusion
    • date: 2020-05-14
    • words: 3895
    • flesch: 51
    • summary: key: cord-011345-w0ke1tqz authors: Howe, Sarah L.; März, Melanie; Krüger-Ziolek, Sabine; Laufer, Bernhard; Pretty, Chris; Shaw, Geoffery M.; Desaive, Thomas; Möller, Knut; Chase, J. Geoffrey title: Measuring lung mechanics of expiratory tidal breathing with non-invasive breath occlusion date: 2020-05-14 journal: Biomed Eng Online DOI: 10.1186/s12938-020-00777-0 sha: doc_id: 11345 cord_uid: w0ke1tqz BACKGROUND AND OBJECTIVE: As a result, monitoring decay rate of flow in response to shuttering or other pressure impulses only gives information on lung elastance.
    • keywords: airflow; average; breathing; cmh; compartment; decay; decaying; driving; dynamic; effort; elastance; expected; expiration; fig; flow; function; healthy; lung; measured; measurements; mechanics; model; muscular; pressure; range; rate; resistance; respiratory; response; rocc; shutter; shuttering; single; spirometry; study; subjects; test; tidal; time
    • versions: original; plain text
39. cord-011408-z8lw8nc6
    • author: Peters, Matthew J.
    • title: Electronic cigarettes: Tumultuous times
    • date: 2019-11-06
    • words: 1498
    • flesch: 48
    • summary: Less than 3 years later, it appears that Donald Trump's developing emergency is not an infectious disease but two phenomena related to electronic cigarettes (EC)-an extraordinary rise of EC use in youth 2 and a multistate outbreak of lung injury associated with EC product use. Tougher controls urged for electronic cigarettes Trends in adolescent vaping Characteristics of a multistate outbreak of lung injury associated with e-cigarette use or vaping-United States An unexpected consequence of electronic cigarette use Outbreak of lung injury associated with e-cigarette use, or vaping Bronx teenager's death is the youngest vaping fatality in U.S Imaging of vaping-associated lung disease Outbreak of lung injury associated with e-cigarette use, or vaping Effects of e-cigarette e-liquid components on bronchial epithelial cells: demonstration of dysfunctional efferocytosis Pathology of vaping-associated lung injury Pulmonary toxicity of e-cigarettes Chronic ecigarette exposure alters the human bronchial epithelial proteome FDA takes new steps to address epidemic of youth e-cigarette use, including a historic action against more than 1,300 retailers and 5 major manufacturers for their roles perpetuating youth access Prevalence of vaping and smoking among adolescents in Canada, England, and the United States: repeat national cross sectional surveys Potential deaths averted in USA by replacing cigarettes with e-cigarettes US Food & Drug Administration.
    • keywords: bronchial; case; cigarettes; disease; epidemic; exposure; findings; human; injury; juul; labs; lung; national; outbreak; people; products; range; related; smoking; states; time; tobacco; united; use; vaping; young; youth
    • versions: original; plain text
40. cord-011781-0yswqubf
    • author: Svanberg, Emilie Krite
    • title: Changes in pulmonary oxygen content are detectable with laser absorption spectroscopy: proof of concept in newborn piglets
    • date: 2020-06-13
    • words: 4609
    • flesch: 46
    • summary: If the light source is placed internally, e.g. through a nasogastric feeding tube or an endotracheal tube, the light travels through the air-filled lung with a shorter path through solid tissue before reaching the skin surface, thereby theoretically leading to higher light intensity at the detector with a larger portion of photons subjected to gas absorption. Compared to electric impedance and ultrasound, GASMAS has the advantage to detect oxygen content and lung volume changes of each breath.
    • keywords: absorption; absorption signal; air; arterial; atelectasis; changes; complications; concentration; content; continuous; dermal; detectable; detector; diode; esophagus; fig; fio; gas; gas absorption; gasmas; induced; infants; information; internal; internal light; laser; light; light source; lung; measured; method; monitoring; neonatal; newborn; optical; oxygen; path; piglets; pleural; pneumothorax; preterm; probe; pulmonary; ray; signal; skin; source; spectroscopy; studies; study; technique; temperature; time; tissue; transmission; tube; vapor; ventilated; volume; water
    • versions: original; plain text
41. cord-012884-56z95uca
    • author: Bargagli, Elena
    • title: Metabolic Dysregulation in Idiopathic Pulmonary Fibrosis
    • date: 2020-08-07
    • words: 6494
    • flesch: 24
    • summary: These dysregulations, observed in metabolic disorders, also characterize aging, leading to pro-inflammatory and pro-fibrotic effects in different organs and inducing lung fibrosis, vascular dysfunction, myocardial fibrosis, nephropathy and insulin secretory defects with increased insulin resistance [53] . Leptin levels are reported to be elevated in serum and correlated with the severity of lung fibrosis, since leptin significantly promotes the epithelial-mesenchymal transition in A549 cells, decreases autophagosome formation, inhibits the lipidation of LC3I to LC3II, and up-regulates the expression of p62 by activating the PI3K/Akt/mTOR pathway
    • keywords: accumulation; activation; adiponectin; adipose; aldosterone; alterations; alveolar; analysis; angiotensin; angt; bal; bronchoalveolar; cell; chronic; controls; damage; development; differentiation; disease; disorders; dysregulated; dysregulation; effects; epithelial; expression; extracellular; factor; fibroblasts; fibrosis; fibrotic; figure; findings; glucose; high; hypoxia; idiopathic; idiopathic pulmonary; inflammation; inflammatory; injury; insulin; interstitial; ipf; iron; lavage; lipid; liver; lung; macrophages; mesenchymal; metabolic; mitochondrial; molecular; network; nintedanib; number; onset; oxidative; oxygen; pathogenesis; pathways; patients; potential; ppar; production; proliferation; proteins; proteomic; pulmonary; pulmonary fibrosis; raas; reactive; recent; receptor; red; regulation; renin; resistance; response; role; sclerosis; serum; signalling; species; stress; studies; study; surfactant; systemic; table; tgf; tissue; transcription; treatment
    • versions: original; plain text
42. cord-016009-qa7bcsbu
    • author: Starkel, Julie L.
    • title: Respiratory
    • date: 2019-10-07
    • words: 22281
    • flesch: 42
    • summary: In Europe, lung disease represents 15% of all deaths -the fourth leading cause. Added together, lung disease rivals the position for the top cause of death.
    • keywords: a1at; absorption; acetylcysteine; acid; activation; activity; acute; addition; adults; affected; air; airway; allergic; allergy; alpha-1; alveolar; alveoli; analysis; antioxidant; antitrypsin; anxiety; arsenic; assess; associated; association; asthma; asthmatic; available; bacterial; balance; benefits; blood; body; breathing; bronchitis; cadmium; cancer; capacity; carbon; cause; cells; cellular; certain; children; chronic; chronic lung; cigarette; cofactors; collagen; common; concentrations; conditions; connective; contrast; control; copd; curcumin; cysteine; cystic; cytokines; dairy; damage; data; day; death; decreased; deficiency; depression; development; diagnosis; diet; dietary; different; dioxide; disease; disorders; doses; effective; effects; emphysema; enzymes; epithelial; essential; evidence; example; excessive; exercise; exposure; factor; fatty; fibroblasts; fibrosing; fibrosis; fibrotic; fig; fish; folate; foods; form; free; fruits; function; genes; genetic; glutathione; good; greater; growth; gsh; gut; health; heavy; help; helpful; high; higher; history; homeostasis; human; idiopathic; ige; immune; impact; impaired; important; improved; increase; individual; induced; infections; inflammation; inflammatory; inhaled; injury; intake; integrative; interstitial; ipf; iron; issues; key; lead; leading; length; levels; life; lifestyle; like; lining; lipid; lipoic; liver; long; low; lower; lung; lung cancer; lung disease; lung function; lung health; lung tissue; magnesium; mechanisms; mice; microbiome; minerals; mucus; muscle; mutations; new; nutrients; nutrition; obstructive; oral; oxidative; oxygen; particles; particular; pathway; patients; people; phytonutrients; play; pneumonia; pneumonitis; pollutants; pollution; potential; powerful; present; prevention; production; products; progression; protective; protein; pulmonary; pulmonary disease; pulmonary fibrosis; quality; quercetin; rate; recent; receptor; reduced; research; respiratory; respiratory disease; respiratory health; response; responsible; results; review; risk; role; selenium; serum; severe; significant; sleep; smoke; smokers; smoking; soluble; status; stress; studies; study; supplementation; support; surfactant; susceptibility; symptoms; syndrome; synthesis; system; systematic; target; telomere; testing; tgf; therapeutic; therapy; time; tissue; toxic; tract; treatment; trigger; type; united; upper; vegetables; vitamin; vitamin d; weight; year; zinc
    • versions: original; plain text
43. cord-016211-8j8n9enn
    • author: Lu, Puxuan
    • title: Highly Pathogenic Avian Influenza
    • date: 2015-04-30
    • words: 9574
    • flesch: 48
    • summary: Isolation of avian infl uenza virus from respiratory specimens such as nasopharyngeal secretion and tracheal aspiration is the classical way to defi ne the diagnosis of human infection by avian infl uenza. H7N9 is a subtype of avian infl uenza virus that is categorized into the family of Orthomyxoviridae .
    • keywords: acute; akes; alveolar; alveolus; ammatory; antibody; ards; avian infl; blood; body; breathing; brosis; cases; cause; cells; changes; chest; china; clinical; conditions; consolidation; contact; cough; days; death; defi; density; diagnosis; diffuse; direct; disease; distress; early; edema; erythrocytes; experience; failure; fever; gas; general; h5n1; h7n9; headache; heart; high; history; human; human infection; human infl; hyperplasia; hypoxemia; increase; infected; infection; infi; infl ammatory; infl uenza; injury; interstitial; large; lesions; like; lung; mild; mmol; multiple; muscle; normal; obvious; onset; organ; pathogenic; pathogenic avian; patients; period; person; pneumonia; positive; poultry; progress; progressive; pulmonary; quantity; rapid; rare; rate; ray; respiratory; severe; shadow; shock; small; soreness; sputum; stage; subject; symptoms; syndrome; temperature; test; time; transmission; type; uenza virus; ventilation; viral; virus; viruses
    • versions: original; plain text
44. cord-016235-2lhrkmrv
    • author: Roden, Anja C.
    • title: Lung
    • date: 2010-05-17
    • words: 12880
    • flesch: 33
    • summary: The effect of recipient's age on lung transplant outcome Pretransplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study Gastroesophageal reflux disease in lung transplant recipients Lung homotransplantation in man Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis Prospective analysis of 1, 235 transbronchial lung biopsies in lung transplant recipients Rejection is reduced in thoracic organ recipients when transplanted in the first year of life C4d deposition in lung allografts is associated with circulating anti-HLA alloantibody Acute and chronic onset of bronchiolitis obliterans syndrome (BOS): are they different entities? Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome Pleural effusion from acute lung rejection Refining the identification of discriminatory genes for rejection in lung transplantation: the largo study Significance of a solitary perivascular mononuclear infiltrate in lung allograft recipients with mild acute cellular rejection Native lung complications in single-lung transplant recipients and the role of pneumonectomy Immunodeficiency-associated lymphoproliferative disorders Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders The US experience with lung transplantation for pulmonary lymphangioleiomyomatosis The diagnosis of obliterative bronchiolitis after heart-lung and lung transplantation: low yield of transbronchial lung biopsy Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant Lung transplantation at Duke University Medical Center Pulmonary inflammation after lung transplantation The incidence of cancer in patients with idiopathic pulmonary fibrosis and sarcoidosis in the UK Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity? Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants GI complications after orthotopic lung transplantation B-cell posttransplant lymphoproliferative disorders in heart and/or lungs recipients: clinical and molecular-histogenetic study of 17 cases from a single institution C3d and the septal microvasculature as a predictor of chronic lung allograft dysfunction Selection and evaluation of recipients for heart-lung and lung transplantation Outcomes of lung transplantation in patients with scleroderma Complications (excluding hyperinflation) involving the native lung after single-lung transplantation: incidence, radiologic features, and clinical importance Evolving strategies in lung transplantation for emphysema Surveillance bronchoscopy in lung transplant recipients: risk versus benefit Clinical implications and longitudinal alteration of peripheral blood transcriptional signals indicative of future cardiac allograft rejection Lung transplantation: a decade of experience Acute humoral rejection of human lung allografts and elevation of C4d in bronchoalveolar lavage fluid Lung transplantation for end-stage pulmonary sarcoidosis: outcome in a series of seven consecutive patients Pulmonary hypertension in patients with bronchiolitis obliterans syndrome listed for retransplantation Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity? Lymphomas after solid organ transplantation: a collaborative transplant study report General overview of lung transplantation and review of organ allocation Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation Bronchoalveolar lavage cell gene expression in acute lung rejection: development of a diagnostic classifier Lung transplantation for lymphangioleiomyomatosis The changing pattern of posttransplant malignancies Does human leukocyte antigen matching influence the outcome of lung transplantation? Several host genetic characteristics have been suggested to modulate acute lung rejection.
    • keywords: activation; acute; acute lung; acute rejection; age; airways; allograft; allograft rejection; alveolar; amr; analysis; antibodies; antibody; antigens; aspiration; association; bal; biopsies; biopsy; blood; bos; bronchioles; bronchiolitis; bronchoalveolar; bronchoscopy; c4d; cases; cause; cell; changes; chest; children; chronic; classification; clinical; cmv; common; complement; complications; consensus; days; death; development; diagnosis; diffuse; disease; disorders; donor; dysfunction; early; ebv; eosinophils; epithelial; evidence; expression; factors; failure; features; fibrosis; fig; findings; fluid; following; function; gene; grade; grading; group; gvhd; heart; high; higher; histologic; hla; human; hyperacute; hypertension; idiopathic; immune; immunosuppression; impact; incidence; increased; infection; infiltrates; inflammation; injury; international; ipah; ipf; ishlt; later; lavage; long; lung; lung allograft; lung injury; lung rejection; lung transplantation; lymphocytic; lymphoproliferative; malignancy; mononuclear; months; mortality; multiple; native; native lung; negative; obliterans; obliterative; organ; outcome; patients; pediatric; perivascular; pneumonia; posttransplantation; presence; present; procedure; process; ptld; pulmonary; recent; recipients; rejection; reperfusion; report; respiratory; revised; risk; severe; significant; similar; single; slt; small; society; solid; specific; stage; studies; study; successful; surveillance; survival; syndrome; table; term; time; tissue; transbronchial; transplant recipients; transplantation; transplanted; treatment; viral; virus; working; years
    • versions: original; plain text
45. cord-016280-d47e3art
    • author: Friedberg, Joseph S.
    • title: Pleura: Anatomy, Physiology, and Disorders
    • date: 2008
    • words: 14507
    • flesch: 42
    • summary: Baltimore: Lippincott Williams and Wilkins Solitary fibrous tumor of the pleura The role of Alimta in the treatment of malignant pleural mesothelioma: an overview of preclinical and clinical trials Malignant mesothelioma-the UK experience Malignant pleural mesothelioma New developments about the association of SV40 with human mesothelioma Multimodality management of malignant pleural mesothelioma Gene expression profiles predict survival and progression of pleural mesothelioma Chemotherapy for malignant pleural mesothelioma: past results and recent developments Chemotherapy for malignant pleural mesothelioma: past results and recent developments Phase IT trial of pleural photodynamic therapy and surgery for patients with non-smallcell lung cancer with pleural spread Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): identification of five groups with different survival Prognostic value of pleural effusion in patients with non-small cell lung cancer Revisions in the International System for Staging Lung Cancer Indications for pleurectomy in malignant effusion Neoadjuvant chemotherapy and operations in the treatment of lung cancer with pleural effusion Malignant pleural effusion in non-small cell lung cancer-time for a stage revision Multimodality treatment programs for malignant pleural mesothelioma using highdose hemithorax irradiation Extrapleural pneumonectomy for lung cancer with carcinomatous pleuritis Prognosis of resected non-small cell lung cancer patients with carcinomatous pleuritis of minimal disease Implications of staging in lung cancer Intraoperative intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis Pleuropneumonectomy and postoperative adjuvant chemotherapy for carcinomatous pleuritis in primary lung cancer: a case report of long-term survival Comparison of pleuropneumonectomy and limited surgery for lung cancer with pleural dissemination Phase IT trial of pleural photodynamic therapy and surgery for patients with non-smallcell lung cancer with pleural spread Gray's Anatomy Minimal Access Surgery in Oncology Chemical pleurodesis for malignant pleural effusion Comparison of thoracic drainage vs. immediate or delayed needle aspiration Treatment of pneumothoraces utilizing small caliber chest tubes The performance of four pleural drainage systems in an animal model of bronchopleural fistula Focal reexpansion pulmonary edema after drainage of large pleural effusions: clinical evidence suggesting hypoxic injury to the lung as the cause of edema Reexpansion pulmonary edema Complications in Cardiothoracic Surgery Smoking and the increased risk of contracting spontaneous pneumothorax Treatment of spontaneous pneumothorax: a more aggressive approach? Management of spontaneous pneumothorax Secondary spontaneous pneumothorax Significance of iatrogenic pneumothoraces Pulmonary Diseases and Disorders Pleural effusions: the diagnostic separation of transudates and exudates Focal reexpansion pulmonary edema after drainage of large pleural effusions: clinical evidence suggesting hypoxic injury to the lung as the cause of edema Transudative effusions Hepatic hydrothorax Outcome analysis of cirrhotic patients undergoing chest tube placement Recurrent pleural effusion complication liver cirrhosis Cytologically proved malignant pleural effusions: distribution of transudates and exudates Management of malignancyassociated pleural effusion: current and future treatment strategies Efficacy of short term versus long term tube thoracostomy drainage before tetracycline pleurodesis in the treatment of malignant pleural effusions Distribution of talc suspension during treatment of malignant pleural effusion with talc pleurodesis Pleurodesis for malignant pleural effusions (Cochrane Review) Outpatient management of malignant pleural effusion by a chronic indwelling catheter Survival and talc pleurodesis in metastatic pleural carcinoma, revisited.
    • keywords: air; approach; appropriate; aspiration; associated; available; benign; bilateral; blebs; blood; cancer; cases; catheter; cause; cavity; cell; chemotherapy; chest; chest cavity; chest tube; choice; chylothorax; clinical; clinician; common; conditions; day; diagnosis; diaphragm; disease; disorders; disruption; drainage; duct; early; edema; effusion; empyema; etiology; exudative; failure; fibrous; fig; fluid; function; gas; glucose; greater; hemithorax; high; iatrogenic; incision; increase; indications; infection; initial; intervention; intraoperative; large; layer; leak; left; level; likely; limited; line; local; lung; lung cancer; lymphatic; malignant; malignant effusion; malignant pleural; management; mediastinal; mesothelioma; metastatic; negative; normal; number; observation; open; option; pain; parapneumonic; parietal; parietal pleura; patient; physiology; placement; plaques; pleural; pleural cavity; pleural drainage; pleural effusion; pleural fluid; pleural mesothelioma; pleural space; pleurodesis; pneumothoraces; pneumothorax; positive; potential; presence; present; presentation; pressure; primary; procedure; pulmonary; radiation; rate; recurrence; resection; result; rib; right; risk; role; secondary; significant; simple; size; small; spontaneous; spontaneous pneumothorax; stage; staging; standard; sterile; surface; surgery; surgical; survival; symptomatic; symptoms; system; talc; technique; tension; tension pneumothorax; therapy; thoracentesis; thoracic; thoracotomy; time; tissue; transudative; trauma; treatment; tube; tumors; underlying; vats; ventilation; visceral; visceral pleura
    • versions: original; plain text
46. cord-016300-vw11c2wt
    • author: Jain, Kewal K.
    • title: Biomarkers of Pulmonary Diseases
    • date: 2017-09-18
    • words: 5584
    • flesch: 38
    • summary: Lung ECM remodeling in healthy controls and COPD patients was investigated in the COPDGene study. One study was done to quantify bronchial lavage (BAL) fluid and serum levels of IL-8, secretory leukocyte protease inhibitor (SLPI), soluble intracellular adhesion molecules-1 (sICAM-1) and sCD14, as surrogate markers of inflammatory and immune response in asthma and COPD patients with similar disease duration time (Hollander et al. 2007 ).
    • keywords: activity; acute; airway; arginase; association; asthma; biomarkers; blood; breath; bronchial; cap; cells; children; chronic; clinical; collagen; control; copd; corticosteroids; cough; crp; cytokine; development; disease; early; ebc; elevated; et al; expression; failure; fev1; findings; function; gene; high; higher; ige; il-8; ild; important; infection; inflammation; inflammatory; information; injury; ip-10; levels; lung; measured; measurements; mortality; nitric; non; obstructive; oxidative; oxide; patients; periostin; plasma; pneumonia; prognostic; protein; pulmonary; respiratory; response; risk; role; sars; serum; severe; severity; significant; sputum; stress; study; tissue; tool; treatment; turnover; type; useful
    • versions: original; plain text
47. cord-016369-tnvlafa2
    • author: Lu, Puxuan
    • title: Human Infected H5N1 Avian Influenza
    • date: 2016-06-23
    • words: 3928
    • flesch: 49
    • summary: After her discharge, her serum collected at the convalescent stage was collaboratively administered to cure a patient with human infected H5N1 avian infl uenza in Shenzhen, Guangdong, China, which is known as the patient with the most serious condition among patients with H5N1 avian infl uenza. Transmission via direct or indirect contact refers to human infection of H5N1 avian infl uenza after close contact to feces of poultry/animal infected by AIV H5N1.
    • keywords: akes; avian; avian infl; blood; body; cases; changes; chest; condition; consolidation; diagnosis; early; examination; glass; ground; h5n1; h5n1 avian; human; infected; infection; infl; infl uenza; large; left; lesions; lower; lung; normal; onset; opacity; patient; pleural; pneumonia; progression; pulmonary; radiological; rapid; rate; ray; scan; stage; temperature; uenza; upper; virus
    • versions: original; plain text
48. cord-016374-38fk66zb
    • author: Shi, Yuxin
    • title: Human Infected H7N9 Avian Influenza
    • date: 2016-06-23
    • words: 8000
    • flesch: 51
    • summary: The left lingual lung lobe was revealed with GGO like opacity and interstitial fi brous cords like opacity ( Swine-origin infl uenza A(H1N1)viral infection: radiographic and CT fi ndings Radiological demonstrations of lung lesions and their dynamic changes in human infected H7N9 avian infl uenza Human infections with the emerging avian infl uenza Clinically, human infected H7N9 avian infl uenza can be categorized into 3 types, namely asymptomatic (latent infection), slight and severe.
    • keywords: absorption; air; avian; avian infl; blood; body; bronchogram; case; chest; clinical; condition; consolidation; contact; cough; count; days; defi; density; diagnosis; early; examination; expectoration; fever; fig; ggo; glass; ground; h7n9; h7n9 avian; high; history; human; infected; infection; infl; infl uenza; laboratory; large; left; lesions; lobe; lower; lower lung; lung; middle; multiple; ned; onset; opacity; patches; patient; pneumonia; positive; poultry; radiological; ray; respiratory; right; scan; severe; signs; small; symptoms; temperature; treatment; uenza; uenza virus; upper; virus
    • versions: original; plain text
49. cord-016617-qadf0xut
    • author: Lagstein, Amir
    • title: Airway Pathology in Lung Transplants
    • date: 2013-06-14
    • words: 7578
    • flesch: 29
    • summary: A case report with autopsy fi ndings Long-term course of bronchiectasis and bronchiolitis obliterans as late complication of smoke inhalation A review of the respiratory effects of smoking cocaine Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant Diacetyl-induced lung disease The histological spectrum of pulmonary graft-versus-host disease in bonemarrow transplant recipients Interstitial pneumonitis and lymphocytic bronchiolitis/bronchitis as a direct result of acute lethal graft-versus-host disease duplicate the histopathology of lung allograft rejection Lymphocytic airway infi ltration as a precursor to fi brous obliteration in a rat model of bronchiolitis obliterans Risk factors for bronchiolitis obliterans: a systematic review of recent publications Obliterative bronchiolitis or chronic lung allograft rejection: a basic science review Bronchiolitis obliterans syndrome-risk factors and therapeutic strategies The registry of the International Society for Heart and Lung Transplantation: twenty-eighth adult lung and heart-lung transplant report-2011 Early detection of chronic pulmonary allograft dysfunction by exhaled biomarkers A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection-Lung Rejection Study-Group Revision of the 1990 working formulation for the classifi cation of pulmonary allograft rejection: Lung Rejection Study Group Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection Allograft vascular disease: comparison of heart and other grafted organs Pulmonary arteriosclerosis in long-term human heart-lung transplant recipients Bronchoscopic monitoring after lung transplantation The controversial role of surveillance bronchoscopy after lung transplantation Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis The sensitivity of transbronchial biopsy for the diagnosis of acute lung rejection Prospective study of transbronchial biopsies in the management of heart-lung and single lung-transplant patients The diagnosis of obliterative bronchiolitis after heart-lung and lung transplantation: low yield of transbronchial lung biopsy Diagnosis of chronic lung transplant rejection by transbronchial biopsy The utility of open lung biopsy following lung transplantation Antibody-mediated rejection in lung transplantation: myth or reality? While OB is perhaps best known as the central feature of chronic lung rejection, it may also occur in a number of non-transplant settings.
    • keywords: acr; acute; acute rejection; addition; airways; allograft; alveolar; ammation; appearance; aspiration; assessment; associated; biopsies; biopsy; boop; bos; bronchiolar; bronchiolitis; bronchitis; cance; cases; cation; cause; cell; changes; chronic; clinical; cmv; common; defi; dense; development; diagnosis; diffi; disease; dysfunction; eosin; epithelial; evidence; factors; features; formulation; grade; heart; high; histologic; inclusions; infection; infi; infl; infl ammation; injury; interstitial; large; low; ltrates; lung; lung rejection; lymphocytic; lymphoid; magnifi; mononuclear; ndings; ned; nonspecifi; obliterans; obliterative; organizing; original; pathologist; patients; perivascular; pieces; pneumocystis; pneumonia; potential; presence; present; pulmonary; recipients; refl; rejection; risk; sensitivity; signifi; small; stains; study; submucosa; syndrome; tbbx; term; tissue; transbronchial; transplant; transplantation; viral; working; yield
    • versions: original; plain text
50. cord-016659-26zz8kaw
    • author: Chen, Feng
    • title: Influenza
    • date: 2016-06-23
    • words: 4131
    • flesch: 40
    • summary: In this case, influenza virus pneumonia manifested as interstitial pneumonia should be differentiated from other viral pneumonia, such as hand-foot-mouth virus pneumonia and measles virus pneumonia. The radiological demonstrations of influenza virus pneumonia resemble to those of other viral pneumonia, and the radiological diagnosis of the primary disease is, therefore, challenging.
    • keywords: acute; air; alveolar; bronchial; chest; consolidation; density; diagnosis; different; disease; distribution; edema; fields; high; influenza; influenza virus; interstitial; lesions; lobar; lobe; lobular; lower; lung; lung fields; lung markings; markings; nodular; nodules; opacities; opacity; patches; pneumonia; pulmonary; radiological; ray; respiratory; scan; small; stage; symptoms; temperature; thickened; thickening; type; virus; virus pneumonia
    • versions: original; plain text
51. cord-016690-3gsq724l
    • author: Li, Hongjun
    • title: HIV/AIDS Related Respiratory Diseases
    • date: 2013-09-30
    • words: 26773
    • flesch: 44
    • summary: Pathogens of HIV related pulmonary infections include parasites, fungi, mycobacteria, viruses, bacteria and toxoplasma gondii. In this section, the clinical manifestations and imaging findings of HIV related pulmonary infections are analyzed and discussed, which provide effective diagnosis basis, so as to reduce the incidence of HIV-related pulmonary infections.
    • keywords: abscess; abscesses; accompanying; acute; addition; advanced; aged; aids; aids patients; aids related; aky; allergic; alveolar; ammation; ammatory; analysis; antibody; aspergillosis; aspergillus; aureus; bacilli; bacteria; biopsy; blood; blurry; body; boundaries; breath; breathing; bronchial; bronchiectasis; brosis; cancer; candida; carinii; caseous; cases; cation; cause; cavities; cavity; cd4; cdc; cell; cell count; central; changes; characteristic; chest; chest pain; chest x; chronic; ciency; classifi; clinical; cmv; common; complicated; confi; cough; count; culture; culty; cysts; cytomegalovirus; days; defi; demonstrations; density; diagnosis; different; diffi; diffuse; direct; disease; distress; distribution; dry; dyspnea; early; edema; effusion; elds; emphysema; equi; examinations; expectoration; exudation; exudative; female; fever; fi ndings; foci; form; fungal; glass; ground; growth; hemoptysis; herpes; high; hilar; hilum; history; hiv; hiv infection; human; hyphae; imaging; immunity; immunocompromised; immunodefi; incidence; increasing; infected; infection; infi; infl; interstitial; interstitial pneumonia; intrapulmonary; invasion; involvement; kaposi; large; lesions; lobes; lower; ltration; ltrative; lung; lung cancer; lung fi; lymphadenectasis; lymphocytes; lymphoma; macrophages; main; male; manifestations; markings; marneffei; mass; masses; mediastinal; middle; miliary; moist; mononuclear; months; multiple; mycobacterium; ndings; necrosis; necrotic; negative; nodes; nodular; nodules; non; ntm; obstructive; occurrence; onset; opportunistic; pain; parenchymal; parenchymal changes; patchy; pathogen; pathological; patients; pcp; penicillium; period; phase; phlegm; pleural; pleuritis; pneumocystis; pneumonia; poor; positive; primary; progression; proliferation; pulmonary; pulmonary infection; pulmonary tuberculosis; quantity; rales; rare; rate; ray; red; related; related pulmonary; reported; respiratory; rhodococcus; sarcoma; scanning; secondary; serum; shadows; shaped; shortness; sign; similar; simplex; skin; small; specifi; spreading; sputum; stage; staining; staphylococcus; surrounding; symptoms; syndrome; systemic; t cell; temperature; test; thickened; tissues; toxoplasma; toxoplasmosis; tract; treatment; tubercle; tuberculosis; tumor; type; typical; uid; unilateral; upper; vascular; vessels; viral; virus; wall; years
    • versions: original; plain text
52. cord-016790-by7cxz1g
    • author: Ahuja, Jitesh
    • title: Imaging of Lung Transplantation
    • date: 2018-04-24
    • words: 3299
    • flesch: 29
    • summary: Mechanisms, diagnosis, and management The Registry of the International Society for Heart and Lung Transplantation: twentysixth official adult lung and heart-lung transplantation report-2009 Acute and chronic rejection after lung transplantation Airway complications after lung transplantation: a review of 151 anastomoses Imaging of lung transplantation: review Vascular complications of lung transplantation Postoperative complications of lung transplantation: radiologic findings along a time continuum Infections after lung transplantation CT findings of pneumonia after lung transplantation Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome Imaging of the chest after lung transplantation Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria A new classification system for chronic lung allograft dysfunction Early bronchiolitis obliterans following lung transplantation: accuracy of expiratory thin-section CT for diagnosis Bronchiolitis obliterans organizing pneumonia (BOOP) in lung transplant recipients Bronchiolitis obliterans with organizing pneumonia versus chronic eosinophilic pneumonia: high-resolution CT findings in 81 patients Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients Lymphoproliferative disease after lung transplantation: comparison of presentation and outcome of early and late cases Intrathoracic lymphoproliferative disorders in the immunocompromised patient: CT findings Post-transplant lymphoproliferative disorder:
    • keywords: acute; airway; allograft; bilateral; biopsy; bronchial; bronchiolitis; cause; chronic; common; complications; consolidation; days; diagnosis; disease; donor; dysfunction; early; effusion; fibrosis; fig; glass; ground; heart; imaging; infection; late; lung; lymphoproliferative; manifestations; months; mortality; nodules; opacity; patients; pleural; pneumonia; pneumothorax; postoperative; primary; pulmonary; radiologic; recipients; rejection; shows; single; stenosis; survival; thickening; time; transplantation; years
    • versions: original; plain text
53. cord-016814-tf17dpo5
    • author: Enes, Sara Rolandsson
    • title: Clinical Application of Stem/Stromal Cells in COPD
    • date: 2019-08-07
    • words: 10760
    • flesch: 35
    • summary: Effects of freeze-thawing and intravenous infusion on mesenchymal stromal cell gene expression Freshly thawed and continuously cultured human bone marrow-derived mesenchymal stromal cells comparably ameliorate allergic airways inflammation in immunocompetent mice Attachment, growth, and detachment of human mesenchymal stem cells in a chemically defined medium Collagen promotes higher adhesion, survival and proliferation of mesenchymal stem cells The extracellular matrixthe under-recognized element in lung disease? Comprehensive review of the recent literature 2010-2012 Mitochondrial transfer between cells can rescue aerobic respiration Cell-tocell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture Mechanisms of mesenchymal stem/stromal cell function Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in vivo models of ARDS Mitochondria in mesenchymal stem cell biology and cell therapy: from cellular differentiation to mitochondrial transfer Mitochondrial dysfunction increases allergic airway inflammation Association between mitochondrial dysfunction and severity and outcome of septic shock Mitochondria in lung diseases Intra-and intercellular quality control mechanisms of mitochondria Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs Monocyte/macrophage-derived microparticles up-regulate inflammatory mediator synthesis by human airway epithelial cells CD18-mediated adhesion is required for the induction of a proinflammatory phenotype in lung epithelial cells by mononuclear cell-derived extracellular vesicles Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation Extracellular vesicle-shuttled mRNA in mesenchymal stem cell communication Biological properties of extracellular vesicles and their physiological functions Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1beta-primed mesenchymal stem cells against sepsis Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis A phase 1b study of placentaderived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smokeinduced damage Bone marrow mesenchymal stem cell transplantation for treatment of emphysemic rats Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors Therapeutic effects of amniotic fluid-derived mesenchymal stromal cells on lung injury in rats with emphysema IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype Impaired function of bone marrow mesenchymal stem cells from immune thrombocytopenia patients in inducing regulatory dendritic cell differentiation through the Notch-1/Jagged-1 signaling pathway Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)-10 and IL-1RN levels Serum from asthmatic mice potentiates the therapeutic effects of mesenchymal stromal cells in experimental allergic asthma The toll-like receptor 3 ligand, poly(I:C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting MiR-143 Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts Hepatocyte growth factor-modified mesenchymal stem cells improve ischemia/reperfusioninduced acute lung injury in rats Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1 Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression Promotion of survival and engraftment of transplanted adipose tissue-derived stromal and vascular cells by overexpression of manganese superoxide dismutase Mesenchymal stem cells overexpressing angiotensin-converting enzyme
    • keywords: acute; addition; adipose; administration; airway; alveolar; approach; authors; biological; body; bone; bone marrow; capacity; cells; challenges; chronic; cigarette; clinical; copd; copd patients; culture; current; cytokines; damage; date; development; differences; different; differentiation; disease; early; ebv; ecm; effects; efficacy; emphysema; enhanced; environment; et al; evs; expansion; experimental; expression; extracellular; factor; fev1; field; following; function; gamma; gene; group; growth; human; human mesenchymal; hypoxia; immune; immunomodulatory; immunosuppressive; impaired; important; improved; induced; induction; inflammation; inflammatory; infusion; injury; insertion; international; intravenous; levels; likely; lung; macrophages; marrow; matrix; mechanisms; medium; mesenchymal; mesenchymal stem; mesenchymal stromal; mice; mitochondria; model; mouse; msc administration; mscs; need; new; number; obstructive; order; oxygen; paracrine; patients; phase; phenotype; placebo; plastic; potency; potential; preclinical; progression; proliferation; properties; pulmonary; quality; rate; reduction; regulatory; respiratory; response; results; role; safety; serum; severe; shock; significant; smoking; society; stage; stem; stem cells; stromal; stromal cells; studies; study; survival; systemic; therapeutic; therapies; therapy; time; tissue; transfer; transplantation; treatment; trials; use; vivo; volume; way
    • versions: original; plain text
54. cord-016869-pzwlxtd6
    • author: Pal, Subrata
    • title: The Lung and Its Transplantation and Artificial Replacement
    • date: 2013-01-08
    • words: 1884
    • flesch: 64
    • summary: Potkey of VAMC Cleveland, Ohio (2009), recently developed one model of artificial lungs. To help combat these problems, artificial lungs have been developed with the goal of replacing or supplementing the respiratory function of the lung.
    • keywords: air; alveolar; alveoli; artificial; blood; bronchioles; carbon; cavity; cells; dioxide; disease; donor; fig; heart; human; larynx; lung; membrane; nasal; open; organs; oxygen; patients; pulmonary; recipient; respiratory; trachea; transplantation
    • versions: original; plain text
55. cord-016947-8f22ukjc
    • author: Mueller-Mang, Christina
    • title: Interstitial Lung Diseases
    • date: 2017-08-24
    • words: 11276
    • flesch: 35
    • summary: The spectrum of morphologic characteristics that are indicative of interstitial lung disease is relatively limited and includes the linear and reticular pattern, the nodular pattern, the increased attenuation pattern (such as ground-glass opacities and consolidation), and the low attenuation pattern (such as emphysema and cystic lung diseases). The spectrum of morphologic characteristics that are indicative of interstitial lung disease is relatively limited and includes the linear and reticular pattern, the nodular pattern, the increased attenuation pattern (such as ground-glass opacities and consolidation), and the low attenuation pattern (such as emphysema and cystic lung diseases).
    • keywords: abnormalities; acute; addition; aep; air; alveolar; alveoli; areas; arrowheads; associated; attenuation; axial; bilateral; bronchiectasis; cases; cause; centrilobular; cep; changes; chest; chronic; clinical; collagen; common; comparison; consolidation; course; cystic; cysts; diagnosis; diffuse; disease; disorders; distribution; dose; drug; dyspnea; edema; emphysema; eosinophilic; et al; features; fibrosis; fibrotic; fig; findings; follow; glass; glass opacities; ground; group; hemorrhage; high; histiocytosis; honeycombing; hrct; hypersensitivity; idiopathic; iips; ild; image; imaging; interlobular; interstitial; interstitial lung; interstitial pneumonia; involvement; ipf; irregular; lam; linear; lobe; lobule; lower; lung; lung disease; mosaic; nodular; nodules; nonspecific; nsip; old; opacities; opacity; organizing; parenchymal; patchy; patients; pattern; peripheral; phase; pneumonia; pneumonitis; predominance; presence; present; pulmonary; quality; radiation; rare; reconstruction; resolution; respiratory; reticular; sarcoidosis; scans; secondary; septa; shows; size; small; spatial; stage; subpleural; symptoms; syndrome; systemic; term; therapy; thickening; thin; tissue; traction; tube; typical; uip; unknown; upper; vascular; volumetric; wall; year
    • versions: original; plain text
56. cord-017016-twwa9djm
    • author: Tomashefski, Joseph F.
    • title: Aspiration, Bronchial Obstruction, Bronchiectasis, and Related Disorders
    • date: 2008
    • words: 20063
    • flesch: 32
    • summary: A study of 36 cases with special reference to the pulmonary lesions The bronchial mucous glands-their hypertrophy and change in intracellular mucus Similarity of the tracheobronchial mucous glands and epithelium in infants with and without cystic fibrosis The innate immune system in cystic fibrosis lung disease The genesis of cystic fibrosis lung disease Pathogenesis of bacterial bronchitis in cystic fibrosis Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology How mutant CFTR may contribute to Pseudomonas aeruginosa infection in cystic fibrosis Lung infections associated with cystic fibrosis Bacterial infections and inflammation in the lungs of cystic fibrosis patients Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation Cystic fibrosis lung inflammation: early, sustained and severe Inflammatory cytokines in cystic fibrosis lungs Normal bronchial epithelial cells constitutively produce the antiinflammatory cytokine interleukin-lO, which is downregulated in cystic fibrosis Early pulmonary inflammation in infants with cystic fibrosis Cytokine secretion by cystic fibrosis airway epithelial cells Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. 279,28o It has long been recognized that patients with CF are predisposed to lung infection.
    • keywords: abnormal; abscess; abscesses; absence; acid; acid aspiration; acute; adjacent; adults; affected; airway; allergic; alveolar; anaerobic; anesthesia; antitrypsin; appearance; areas; arteries; artery; arthritis; aspirate; aspiration; aspiration pneumonia; associated; asthma; atelectasis; atresia; authors; autopsy; bacteria; barium; blood; bodies; body; bronchial; bronchial obstruction; bronchiectasis; bronchiectasis bronchiectasis; bronchioles; bronchiolitis; bronchitis; bronchocentric; bronchogenic; bronchopulmonary; bronchus; campbell; cartilage; cases; cause; cavities; cavity; cells; cellulose; central; cftr; changes; chapter; chest; children; chloride; cholesterol; chronic; ciliary; clinical; collapse; colleagues; common; complication; components; conditions; congenital; contrast; correlation; cough; course; cylindrical; cystic; cystic fibrosis; cysts; damage; death; defects; deficiency; degree; diagnosis; difficult; diffuse; dilatation; direct; disease; disorders; droplets; dyskinesia; early; effects; emphysema; endobronchial; endogenous; epithelial; etiology; experimental; factors; fat; features; fibrosis; fibrosis lung; fibrotic; fig; findings; fistulas; fluid; follow; food; foreign; formation; fragments; frequency; frequent; function; fungal; gangrene; gastric; general; giant; glands; granulomas; greater; group; hemoptysis; hemorrhage; histologic; human; hypertension; idiopathic; immunodeficiency; impaired; important; incidence; infection; inflammation; inflammatory; inhalation; injury; interstitial; involved; involvement; kartagener; kayexalate; large; left; lesions; like; lipid; lipid pneumonia; lobe; lobe syndrome; localized; loss; lower; lumen; lung; lung abscess; lung disease; lung parenchyma; lymph; macrophages; manifestations; material; middle; mineral; mucoid; mucus; mutations; nasal; necrosis; necrotic; necrotizing; neutrophils; new; nodes; nonobstructive; normal; obliterans; obstruction; oil; oils; oily; oral; organisms; organizing; parenchyma; particles; pathogenesis; pathologic; patients; pcd; pneumonia; pneumonitis; polystyrene; position; positive; postoperative; present; primary; products; pulmonale; pulmonary; pulmonary disease; pulmonary fibrosis; radiographic; radiologic; reaction; recurrent; reduced; reflux; related; report; respiratory; response; result; review; rheumatoid; right; role; saccular; scan; secondary; secretions; segments; series; severe; significant; similar; sinusitis; small; sodium; specific; spectrum; sputum; squamous; stain; starch; stomach; studies; study; surface; surgery; symptoms; syndrome; systemic; tablet; thin; tissue; torsion; toxicity; tracheal; tract; traction; treatment; tumor; type; ultrastructural; upper; variable; vegetable; wall; williams; years; yellow; young; zones
    • versions: original; plain text
57. cord-017021-n6rpuvwd
    • author: Marriott, Deborah J.
    • title: Common Infections Following Lung Transplantation
    • date: 2018-08-31
    • words: 11700
    • flesch: 34
    • summary: In lung transplant recipients PIV infection can lead to loss of lung function and bronchiolitis obliterans syndrome. A prospective study compared 50 lung transplant recipients with respiratory virus infection with 50 uninfected recipients and demonstrated that those with a respiratory virus infection had a greater risk of acute rejection, bronchiolitis obliterans syndrome and death
    • keywords: abscessus; active; agents; amphotericin; anti; antifungal; antimicrobial; aspergillus; associated; aureus; available; bacteria; bcc; biopsy; blood; bronchiolitis; burkholderia; candida; cases; cause; cell; centres; chest; clinical; cmv; cns; common; community; complex; contact; control; culture; cystic; data; detection; diagnosis; disease; donor; drug; e.g.; endemic; environmental; epidemiology; factors; fibrosis; fig; fluconazole; fungal; fungi; general; gram; guidelines; high; hmpv; hospital; human; immune; immunocompromised; immunosuppression; important; incidence; infection; infection control; influenza; invasive; isolates; isolation; laboratory; latent; lesions; long; lung; lung transplant; lung transplantation; measures; months; mortality; mycobacterium; negative; nocardia; non; ntm; oral; organ; organ transplant; organisms; outcomes; patients; pcr; period; person; pneumocystis; pneumonia; population; positive; post; practice; precautions; prior; prophylaxis; pseudomonas; pulmonary; reactivation; recipients; regimen; rejection; resistant; respiratory; results; ribavirin; risk; scedosporium; setting; severe; significant; single; site; skin; society; solid; species; specific; sputum; stain; standard; study; susceptibility; symptoms; syndrome; testing; therapy; time; tissue; transmission; transplant; transplant recipients; transplantation; treatment; tuberculosis; variety; viral; viruses; voriconazole; year
    • versions: original; plain text
58. cord-017030-tzuyo6tx
    • author: Henao-Martínez, Andrés F.
    • title: Infections in Heart, Lung, and Heart-Lung Transplantation
    • date: 2018-12-08
    • words: 11550
    • flesch: 29
    • summary: Although relatively rare in heart transplant recipients (frequency <1%), Nocardia is only second in frequency in heart transplant after lung transplant recipients Trypanosoma cruzi infection reactivation manifested by encephalitis in a Chagas heart transplant recipient Central nervous system infections in heart transplant recipients Listeria meningitis in transplant recipients Progressive multifocal leukoencephalopathy in transplant recipients Progressive multifocal leukoencephalopathy in a heart transplant recipient following rituximab therapy for antibody-mediated rejection Clinical spectrum of gram-positive infections in lung transplantation Frequency of Pseudomonas aeruginosa colonizations/infections in lung transplant recipients Non-tuberculous mycobacterial infection among lung transplant recipients: a 15-year cohort study Nocardia infection in lung transplant recipients Challenges in the diagnosis and management of Nocardia infections in lung transplant recipients Fungal infections after lung transplantation Significance of blood stream infection after lung transplantation: analysis in 176 consecutive patients Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management The incidence of invasive aspergillosis among solid organ transplant recipients and implications for prophylaxis in lung transplants Risk factors and outcomes in lung transplant recipients with nodular invasive pulmonary aspergillosis Immune reconstitution syndrome-like entity in lung transplant recipients with invasive aspergillosis Anastomotic infections in lung transplant recipients Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America Cellulitis caused by Cryptococcus neoformans in a lung transplant recipient An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients Cytomegalovirus in transplantation -challenging the status quo Cytomegalovirus and lung transplantation A polymorphism linked to elevated levels of interferon-gamma is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome Ganciclovir-resistant cytomegalovirus (CMV) infections among lung transplant recipients are associated with poor outcomes despite treatment with foscarnet-containing regimens Community-acquired respiratory viral infections in lung transplant recipients Incidence and outcomes of respiratory viral infections in lung transplant recipients: a prospective study Viral infections in lung transplant recipients Antiviral agents for the treatment and chemoprophylaxis of influenza -recommendations of the Advisory Committee on Immunization Practices (ACIP)
    • keywords: abdominal; aeruginosa; allograft; antifungal; antimicrobial; aspergillosis; aspergillus; associated; aureus; bacteremia; bacterial; blood; bloodstream; candida; cardiac; cases; cause; cell; centers; chagas; chronic; clinical; cmv; cns; colonization; common; community; complications; cruzi; cryptococcus; cystic; cytomegalovirus; d+/r−; days; death; development; diagnosis; disease; donor; early; ebv; encephalitis; endemic; epidemiology; factors; failure; fibrosis; frequent; fungal; fungi; graft; gram; heart; heart transplant; heart transplantation; hepatitis; herpes; high; higher; history; hsv; immunosuppression; important; incidence; increase; infections; influenza; invasive; involvement; late; listeria; lung; lung recipients; lung transplant; lung transplantation; management; manifestations; median; mediastinitis; meningitis; months; morbidity; mortality; mycobacterium; negative; nocardia; nodules; non; nosocomial; ntm; organ; organ transplant; organisms; osteomyelitis; outcomes; patients; period; pneumonia; population; posttransplant; potential; presence; present; previous; primary; prophylaxis; pseudomonas; pulmonary; rare; rate; reactivation; recipients; rejection; reported; respiratory; review; risk; scedosporium; setting; significant; single; skin; solid; sot; species; spp; staphylococcus; surgery; surgical; survival; symptoms; syndrome; therapy; time; toxoplasma; toxoplasmosis; tract; transplant; transplant patients; transplant recipients; transplantation; treatment; trypanosoma; tuberculosis; type; viral; virus; viruses; vzv; year; zoster
    • versions: original; plain text
59. cord-017248-a37t31u1
    • author: None
    • title: Alphabetic Listing of Diseases and Conditions
    • date: 2010-05-17
    • words: 48773
    • flesch: 37
    • summary: Peptic ulcers may be associated with emphysema,* tuberculosis,* and other chronic pulmonary diseases. Procedures See under Alcoholism and alcohol intoxication.
    • keywords: abdomen; abdominal; abnormalities; abscess; abscesses; absence; absent; abuse; accident; acid; acute; adjacent; adrenal; adult; affected; aids; air; airway; alcohol; alcoholic; alpha; alveolar; amounts; amyloidosis; analysis; anemia; anesthesia; aneurysm; angiopathy; anomalies; anomaly; anterior; anthrax; antitrypsin; aorta; aortic; aortitis; appearance; appropriate; arch; areas; arsenic; arterial; arteries; arteriography; artery; arthritis; aspiration; associated; associated conditions; association; asthma; atherosclerosis; atresia; atrial; atrioventricular; atrium; atrophy; autoimmune; autopsy; autopsy procedures; available; bacterial; base; basic; basilar; bilateral; bile; biliary; biochemical; bladder; blood; blood alcohol; blue; bodies; body; bone; bowel; bowel disease; brain; breast; bronchitis; bubbles; bullet; bums; cachexia; calcification; calcium; cancer; carbon; carboxyhemoglobin; carcinoma; cardiac; cardiomyopathy; cases; cause; cava; cavities; cavity; cell; cerebral; cervical; chain; chambers; changes; chapter; characteristic; chemical; chest; childhood; children; chloride; chronic; circumstances; cirrhosis; clinical; clothing; coarctation; colitis; colon; column; common; comparison; complete; complications; concentrations; conditions; congenital; contents; coronary; cranial; crash; crohn; culture; cutaneous; cyanide; cystic; cysts; death; decedent; decompression; defect; deficiency; degeneration; demyelination; deposits; dermatomyositis; determination; diabetes; diagnosis; difficult; diffuse; dilatation; discoloration; disease; disorders; dissection; distal; diving; double; drowning; drug; dry; ductal; ducts; dust; dystrophy; edema; electron; embolism; emphysema; encephalitis; encephalopathy; endocarditis; endocrine; enterocolitis; entry; eosinophilic; epstein; erythematosus; esophagus; ethanol; ethylene; evaluation; evidence; examination; examiner; example; expected; expected findings; exposure; extent; external; external examination; extremities; eyes; face; factor; failure; familial; fatal; fatty; features; feet; femoral; fetalis; fever; fibers; fibrosis; fig; findings; fire; fistula; fixation; fluid; foam; follow; food; foramen; foreign; formalin; fractures; free; fresh; frozen; fungal; ganglia; gas; gastric; gastrointestinal; general; giant; gieson; glands; glass; glomerulonephritis; glycogenosis; glycol; graft; granulomas; granulomatosis; great; grocott; growth; hair; half; hand; head; heading; heart; heart disease; heavy; helpful; hemolytic; hemorrhages; hepatic; hepatitis; hereditary; high; histologic; histologic sections; histologic study; history; hiv; hodgkin; homicide; hospital; host; human; hydrops; hypercalcemia; hypertension; hypertrophy; hypoplasia; hypoxia; identification; idiopathic; immunodeficiency; impact; infantile; infants; infarctions; infected; infection; infective; inferior; infiltrates; inflammatory; information; injuries; injury; instances; insufficiency; intact; internal; interpretation; interstitial; interventions; intestinal; intoxication; investigation; involved; involvement; ischemic; joints; kidney; laboratories; laboratory; lacerations; large; larynx; lateral; lead; left; length; lesions; leukemia; level; like; list; literature; liver; liver disease; location; long; loss; lower; lung; lupus; lymphocytic; lymphoma; main; major; malformation; malignant; manifestations; marrow; material; matter; measure; mechanism; meconium; medical; mellitus; meningitis; mercury; metabolic; metastases; methenamine; methods; microbiologic; microbiologic study; microscopy; midline; mitral; monoxide; motor; mouth; mucosa; multiple; muscles; muscular; myocarditis; myocardium; neck; necrosis; necrotizing; needle; negative; nerves; nitrogen; nodes; nodosa; note; nucleus; number; objects; obstruction; ofthe; old; optic; oral; organs; origin; osteomalacia; osteonecrosis; osteoporosis; pancreas; pancreatitis; panniculitis; paper; paraffin; parathyroid; pas; patent; pathologist; pathology; patients; perforation; perfuse; pericardial; pericarditis; peripheral; persistent; persons; photograph; place; placenta; plasma; pleural; pneumoconiosis; pneumonia; pneumonitis; pneumothorax; poisoning; police; polyarteritis; polycystic; polymyositis; polyposis; porphyria; position; positive; possible; possible associated; posterior; postmortem; potassium; precautions; premature; preparation; prepare; presence; present; presenting; previous; primary; procedures; procedures possible; progressive; prosthetic; protein; proximal; pulmonary; pulmonary disease; purpura; pyelonephritis; radiation; rare; reaction; recent; record; recurrent; red; references; rejection; related; related terms; removal; renal; renal disease; repair; report; reportable; request; respiratory; resuscitation; retinal; review; rheumatoid; rickets; right; risk; roentgenograms; room; routine; rupture; sac; samples; sampling; sarcoidosis; scalp; scene; sclerosis; scuba; search; secondary; sections; septal; septicemia; septum; serologic; serum; severe; short; sickness; signs; silver; similar; single; sinus; sites; situ; size; sjogren; skeletal; skin; skull; small; smears; snap; sodium; soft; solution; special; specific; specimen; specimen preparation; spinal; spine; spleen; stain; states; stenosis; stomach; storage; studies; study; subacute; subcutaneous; sudan; sudden; suffocation; superior; surfaces; surgery; surgical; survival; swelling; syndrome; synonyms; syphilis; syphilitic; syringe; systemic; techniques; terms; tests; thalassemia; therapy; thickness; thoracic; thrombocytopenic; thrombosis; thyroiditis; time; tissue; tongue; total; toxicity; toxicologic; toxicologic study; trachea; tract; transplantation; transposition; trauma; treatment; tricuspid; truncal; tuberculosis; tubular; tumor; type; ulcers; underlying; unknown; unspecified; upper; uremic; urinary; urine; useful; values; valve; valvular; van; varicella; vascular; vasculitis; vehicle; veins; vena; venous; ventricle; ventricular; verhoeff; vessels; victim; viral; virus; vitamin; vitreous; volume; wall; water; weight; white; wounds; year
    • versions: original; plain text
60. cord-017412-1avevzya
    • author: Losada, Liliana
    • title: The Human Lung Microbiome
    • date: 2010-10-11
    • words: 10016
    • flesch: 28
    • summary: Lastly, Wu et al. have provided evidence to suggest that viral infections have a causal role in asthma initiation and development where they show that viral infection during the first 4 months of age is strongly correlated with the development of asthma by age 5 (Wu et al., 2008) . To test this hypothesis, 16S rRNA sequence analysis was performed on BAL samples from 42 subjects, 28 CF patients, and 14 other disease controls (Harris et al., 2007) .
    • keywords: 16s; addition; aeruginosa; age; airway; allergens; allergic; alveolar; analysis; antibiotic; aspergillus; associated; association; asthma; atopy; bacterial; bal; biopsy; body; bronchial; bronchiectasis; bronchopulmonary; causes; cells; characterization; childhood; children; chronic; clinical; colonization; colonized; common; communities; components; copd; culture; cystic; data; detection; development; different; disease; diversity; dna; early; emphysema; environmental; epithelium; et al; evidence; exacerbations; exposure; factors; fibrosis; flora; fumigatus; function; fungal; fungi; fungus; gas; genetic; health; hiv; human; identification; idiopathic; immune; immunodeficiency; independent; individuals; infections; inflammation; inflammatory; levels; likely; lower; lung; methods; microbes; microbial; microbiome; microorganisms; molecular; mucociliary; mucus; multiple; normal; ntm; numbers; obstructive; organisms; pathogenesis; pathogens; patients; physical; pneumocystis; pneumonia; population; possible; present; prevalence; procedure; pulmonary; recent; regions; relationship; respiratory; response; rhinovirus; risk; role; rrna; samples; sampling; sensitization; sequence; sequencing; severe; severity; single; skin; small; smokers; smoking; species; specific; sputum; sterility; studies; study; subjects; symptoms; system; techniques; therapy; tissue; tract; treatment; viral; viruses; wheezing; years
    • versions: original; plain text
61. cord-017856-4fccnygg
    • author: Roden, Anja C.
    • title: Pathology of Lung Rejection: Cellular and Humoral Mediated
    • date: 2018-04-24
    • words: 7788
    • flesch: 31
    • summary: For instance, the recipient alloimmune response is thought to be related to the recognition of differences to donor antigens leading to acute lung allograft rejection. Several host genetic characteristics have been studied that may modulate acute lung rejection.
    • keywords: acute; acute rejection; addition; adult; agreement; airway; allograft; alveolar; amr; antibodies; antibody; antigens; biopsies; biopsy; bos; bronchiolitis; c4d; capillary; cells; cellular; chronic; clinical; complement; cryobiopsies; damage; days; deposition; diagnosis; diffuse; donor; dsa; dysfunction; endotheliitis; epithelial; evidence; factors; features; fig; findings; following; grade; heart; higher; histologic; histopathologic; hla; human; humoral; hyperacute; incidence; increased; infection; infiltrates; inflammation; injury; international; ishlt; kappa; low; lung; lung allograft; lung transplantation; lymphocytic; mononuclear; morphologic; neutrophils; obliterans; obliterative; organ; pathology; patients; perivascular; presence; pulmonary; recent; recipients; rejection; report; risk; sensitivity; single; small; society; specific; specimens; staining; studies; study; surveillance; syndrome; tissue; transbronchial; transplantation; treatment; vitamin
    • versions: original; plain text
62. cord-018001-ris02bff
    • author: Garrido, Guillermo
    • title: Medical Course and Complications After Lung Transplantation
    • date: 2018-06-23
    • words: 5548
    • flesch: 28
    • summary: Lung transplants have the highest incidence of invasive aspergillosis among solid organ transplant recipients, and it is the most common invasive fungal infection in lung transplant. However, survival of lung transplant recipients is shorter compared to patients with other solid organ transplants, due to many unique features of the lung allograft.
    • keywords: acr; acute; airway; allograft; anastomotic; antibodies; antibody; associated; bacterial; bleeding; blood; bos; bronchial; cancer; cases; cause; chronic; clad; clinical; cmv; common; complications; development; diagnosis; disease; donor; dysfunction; early; effusions; empyema; end; factors; fibrosis; fungal; group; heart; high; hla; immunosuppressive; impact; incidence; infections; injury; international; kidney; life; long; lung; lung allograft; lung transplantation; major; management; medical; mortality; organ; outcomes; patients; period; pgd; pleural; population; post; postoperative; present; primary; pulmonary; quality; recipients; rejection; related; reported; resistant; respiratory; risk; severe; significant; single; society; solid; stenosis; study; surgery; surgical; survival; syndrome; term; time; transbronchial; transplant; transplant recipients; transplantation; treatment; use; viral; virus; years
    • versions: original; plain text
63. cord-018086-klels5e3
    • author: Van der Kaaij, N.P.
    • title: Ischemia-reperfusion Injury of the Lung: Role of Surfactant
    • date: 2005
    • words: 4318
    • flesch: 34
    • summary: Structural and functional changes of surfactant protein a induced by ozone Bronchoscopic surfactant administration preserves gas exchange and pulmonary compliance after single lung transplantation in dogs Combined exogenous surfactant and inhaled nitric oxide therapy for lung ischemia-reperfusion injury in minipigs Effect of hypothermic pulmonary artery flushing on capillary filtration coefficient Effect of flush-perfusion with eurocollins solution on pulmonary arterial function Effects of lung preservation with euro-collins and university of wisconsin solutions on endotheliumdependent relaxations Low-potassium dextran solution ameliorates reperfusion injury of the lung and protects surfactant function Pulmonary surfactant-associated protein a enhances the surface activity of lipid extract surfactant and reverses inhibition by blood proteins in vitro Ultrastructural studies of acute rejection following single lung transplantation in the rat±histological and immunohistological findings Exogenous surfactant improves survival and surfactant function in ischaemia-reperfusion injury in minipigs Flush perfusion with low potassium dextran solution improves early graft function in clinical lung transplantation Evaluation of surfactant treatment strategies after prolonged graft storage in lung transplantation Exogenous surfactant treatment before and after sixteen hours of ischemia in experimental lung transplantation Increase of c-reactive protein and decrease of surfactant protein a in surfactant after lung transplantation Lung preservation: The importance of endothelial and alveolar type ii cell integrity Synthetic surfactant (exosurf) inhibits endotoxin-stimulated cytokine secretion by human alveolar macrophages Phagocytic functions and tumor necrosis factor secretion of human monocytes exposed to natural porcine surfactant (curosurf). Pathophysiology of lung ischemia reperfusion injury.
    • keywords: aggregate; alveolar; alveolus; atp; capillary; cell; compliance; damage; data; decrease; der; edema; effects; endothelial; exogenous; formation; function; high; hours; human; important; increase; injury; intracellular; ischemia; kaaij; lung; lung ischemia; lung transplantation; membrane; model; normal; phospholipid; pool; preservation; production; proteins; pulmonary; recycling; reperfusion; reperfusion injury; results; role; ros; secretion; serum; small; studies; surface; surfactant; system; tension; therapy; transplantation; treatment; use; warm
    • versions: original; plain text
64. cord-018134-k4vdqlgs
    • author: Eisenberg, Ronald L.
    • title: Pneumonia
    • date: 2019-11-01
    • words: 2013
    • flesch: 30
    • summary: Aspergilloma -solid homogeneous, rounded, mobile mycetoma that develops in a pre-existing cyst or cavity (primarily upper lobe) in a patient with underlying lung disease and is separated from its wall by a crescentic air space (air crescent sign) (see Fig. • Although traditionally considered a disease of children and young adults, with the dramatic decrease in the prevalence of tuberculosis (especially in children and young adults), primary pulmonary disease can develop at any age • Primary tuberculosis may affect any lobe, so that the diagnosis cannot be excluded because the infection is not in the upper lobe Fig.
    • keywords: air; aspergillosis; associated; bud; cavitation; characteristic; chest; chronic; clinical; common; consolidation; debilitated; diagnosis; diffuse; disease; empyema; fig; figs; fluid; homogeneous; imaging; individuals; infection; lobar; lobe; lung; nodules; opacities; patients; pattern; pleural; pneumonia; primary; pulmonary; radiographs; right; sign; space; tree; tuberculosis; upper; wall
    • versions: original; plain text
65. cord-018243-hyvu9nuq
    • author: Salman, Huda
    • title: Fibrosing Alveolitis in Hematologic Malignancy Patients Undergoing Hematopoietic Cell Transplantation
    • date: 2010-08-19
    • words: 6992
    • flesch: 27
    • summary: Hence, while opportunistic infections still contribute to chronic lung disease, late sequelae resulting from antineoplastic therapy have been identified and reported. Chronic pulmonary disease following allogeneic HSCT likely involves an initial insult to lung parenchyma followed by an ongoing inflammatory process involving the interplay between recruited donor-derived immune cells and the resident cells of the pulmonary vascular endothelium and interstitium.
    • keywords: acute; afo; agents; airway; allogeneic; alveolar; alveolitis; aspergillosis; associated; association; bal; biopsy; bleomycin; bone; brob; bronchiolitis; cancer; cases; cell; changes; chemotherapy; chest; chronic; clinical; complications; condition; cop; corticosteroids; course; cyclophosphamide; dad; development; diagnosis; diffuse; disease; dlco; dose; drug; dysfunction; early; evidence; factor; failure; fibrosis; findings; function; fvc; gemcitabine; graft; gvhd; hematologic; hematopoietic; high; histopathologic; hodgkin; host; hsct; idiopathic; incidence; increased; infection; inflammation; injury; interstitial; invasive; late; lung; malignancies; marrow; methotrexate; models; months; mortality; nodules; noninfectious; normal; obliterans; obstructive; old; onset; organizing; patients; pneumonia; pneumonitis; progressive; pulmonary; radiation; radiographic; recipients; related; resolution; respiratory; risk; rld; role; severe; significant; spectrum; stem; study; syndrome; therapy; toxicity; transplantation; treatment; use
    • versions: original; plain text
66. cord-018452-qyf2vymf
    • author: Sica, Valentina
    • title: Pathophysiologic Role of Autophagy in Human Airways
    • date: 2016-03-07
    • words: 7010
    • flesch: 25
    • summary: In summary, although autophagy generally (but not always) promote the progression of pulmonary malignancies and increases the resistance of lung cancer cells to chemo-and radiotherapeutic regimens, additional experiments are required to understand whether combinatorial treatments involving autophagy inhibitors constitute a clinically viable approach against pulmonary neoplasms. Furthermore, the higher expression of autophagy proteins has been linked to lung epithelial cell death, airway dysfunction and emphysema in response to CS.
    • keywords: aat; able; accumulation; activation; activity; acute; airway; ammation; ammatory; anti; antitrypsin; apoptosis; asthma; asthmatic; atg5; autophagy; beclin; broblasts; brosis; cancer; cells; cellular; cftr; chronic; cient; clearance; common; complex; conditions; copd; cystic; death; defi; degradation; dependent; depletion; development; disease; ecm; emphysema; epithelial; essential; evidences; exposure; expression; fact; fi brosis; functions; genetic; heme; ho-1; homeostasis; human; hyperoxia; hypertension; idiopathic; immune; increase; infection; infl; inhibition; inhibitors; injury; intracellular; ipf; lc3; level; like; liver; lung; machinery; macrophages; malignant; mechanisms; mice; mitophagy; molecular; mtor; mucus; mutant; mutation; non; obstructive; oxygen; p62; pathogenesis; pathway; patients; pharmacological; pink1; production; profi; progression; protein; pulmonary; rapamycin; reduced; response; role; senescence; smoke; specifi; stress; tgf; th2; therapeutic; tissue; transformation; treatment; tumor; type; vivo
    • versions: original; plain text
67. cord-018659-rxzy6k3b
    • author: Danziger-Isakov, Lara
    • title: Posttransplant Complications and Comorbidities
    • date: 2018-01-08
    • words: 6906
    • flesch: 27
    • summary: Respiratory virus Bacteria account for about 50% of infections post lung transplant with pneumonia being most frequent. Obtaining cultures of respiratory, blood, urine, and wound samples with accurate identification and determination of drug sensitivity is critical in the treatment of bacterial infection post lung transplant.
    • keywords: adenovirus; adult; aeruginosa; allograft; antiviral; aspergillus; associated; bacterial; cases; cause; children; chronic; clinical; cmv; colonization; common; complications; consistent; cystic; cytomegalovirus; danziger; detection; diagnosis; disease; epidemiology; et al; factors; fibrosis; fungal; ganciclovir; human; identification; incidence; infection; influenza; international; intravenous; invasive; isakov; kotton; liu; lower; lung; lung transplant; lung transplantation; months; mortality; mrsa; multidrug; oral; organ; patients; pcr; pediatric; pediatric lung; pneumonia; population; positive; posttransplant; pretransplant; prevention; prophylaxis; pulmonary; recipients; resistant; respiratory; risk; rsv; severe; shoham; significant; solid; species; specific; studies; study; survival; symptoms; therapy; time; tract; transplant; transplant recipients; transplantation; treatment; valganciclovir; viral; viruses; years; young
    • versions: original; plain text
68. cord-019063-mcxbl8mv
    • author: Vijayan, Vannan K.
    • title: Diagnosis of Pulmonary Parasitic Diseases
    • date: 2013-06-05
    • words: 6672
    • flesch: 35
    • summary: World Health Organization Laboratory diagnosis of malaria infection-a short review of methods Malaria diagnosis: a brief review Rapid diagnostic tests for malaria parasites Rapid diagnostic testing for malaria A review of malaria diagnostic tools: microscopy and rapid diagnostic test (RDT) Co-infections acquired from Ixode ticks Acute respiratory failure in patients treated for babesiosis Diagnosis of pulmonary infection with Toxoplasma gondii in immunocompromised HIV-positive patients by real time PCR Clinical and diagnostic management of toxoplasmosis in the immunocompromised patient Eosinophilic lung disease in the tropics Parasitic diseases of the respiratory tract Spontaneous rupture of lung echinococcal cyst causing anaphylactic shock and respiratory distress syndrome Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD Pulmonary cystic echinococcosis Echinococcus multilocularis Disseminated alveolar echinococcosis mimicking a metastatic malignancy The immunodiagnosis of Echinococcus multilocularis infection Pulmonary schistosomiasis Pulmonary manifestations of early Schistosoma infection in nonimmune travelers Katayama fever; an acute manifestation of schistosomiasis Schistosomiasis associated pulmonary hypertension A diagnostic dilemma of right lower lobe collapse caused by pulmonary bilharsiasis Acute schistosomiasis in nonimmune travelers: chest CT fi ndings in 10 patients Pathophysiology, diagnosis, and treatment Detection of circulating antigens in patients with active Schistosoma haematobium infection Studies on clinical manifestations, diagnosis and control of paragonimiasis in China Pulmonary paragonimiasis: an evaluation of roentgen fi ndings in 38 positive sputum patients in an endemic area in Thailand Clinicoradiologic features of pleuropulmonary Paragonimus westermani on Kyushu Island Evaluation of human IgG subclass antibodies in the serodiagnosis of Paragonimus heterotremus Tropical parasitic lung diseases Strongyloidiasis and other intestinal nematode infections Eosinophilic lung disease (or how to slice PIE) Ascariasis and hookworm Possible approach for serodiagnosis of ascariasis by evaluation of immunoglobulin G4 response using Ascaris lumbricoides somatic antigen Nature and causes of hookworm anemia Differentiation between the human hookworm Ancylostoma duodenale and Necator americanus using PCR-RFLP Biology and immunology of human strongyloidiasis Disseminated Strongyloides stercoralis in human immunodefi ciency virus-infected patients: treatment failure and review of literature Pulmonary manifestations of strongyloidiasis Strongyloides stercoralis infestation associated with septicemia due to intestinal transmural migration of bacteria Corticosteroidinduced asthma: a manifestation of limited hyperinfection syndrome due to Strongyloides stercoralis Diagnosis of Strongyloides stercoralis infection A simple modification of the Baermann method for diagnosis of strongyloidiasis Evaluation of three methods for laboratory diagnosis of Strongyloides stercoralis infection Diagnosis of pulmonary strongyloidiasis by bronchoalveolar lavage Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area Tropical pulmonary eosinophilia Acute tropical pulmonary eosinophilia: characterization of the lower respiratory tract infl ammation and its response to therapy Tropical pulmonary eosinophilia: analysis of antifi larial antibody localized to the lung Pulmonary eosinophilia: progress in respiration research Tropical pulmonary eosinophilia Re-examination of the diagnostic criteria of tropical pulmonary eosinophilia In certain situations, invasive investigations such as fiberoptic bronchoscopic evaluation (transbronchial lung biopsies and bronchoalveolar lavage studies) and thoracic surgical procedures (thoracoscopy and open lung biopsy) may be required for a diagnosis and also to exclude other lung diseases.
    • keywords: abscess; active; acute; amebiasis; amebic; anemia; antibodies; antibody; antigen; associated; asthma; asymptomatic; biopsy; blood; cases; cells; chest; chronic; clinical; common; cough; cyst; cystic; defi; detection; diagnosis; direct; dirofi; diseases; dispar; distress; dyspnea; echinococcus; effusion; eggs; elevated; endemic; entamoeba; eosinophilia; examination; falciparum; features; fever; helminthic; hemoptysis; histolytica; history; hookworm; human; hydatid; hypertension; important; infected; infection; infi; intestinal; lariasis; larvae; leishmaniasis; leukocytosis; life; liver; loss; ltrates; lung; lung diseases; malaria; manifestations; method; molecular; ndings; pain; paragonimiasis; parasites; parasitic; patients; pcr; peripheral; plasmodium; pleural; present; pulmonary; respiratory; result; rupture; samples; schistosoma; schistosomiasis; severe; sign; smears; species; specifi; specimens; sputum; stercoralis; stool; strongyloides; strongyloidiasis; studies; symptoms; syndrome; test; toxocara; toxoplasmosis; tpe; treatment; tropical; uid; useful; visceral; wheezing
    • versions: original; plain text
69. cord-020764-5tq9cr7o
    • author: Vertrees, Roger A.
    • title: Tissue Culture Models
    • date: 2010-05-21
    • words: 11305
    • flesch: 33
    • summary: Currently, many terms are used that can be encompassed by the term: organ culture, cell culture, primary explants, and ex vivo propagation all deal with the in vitro cultivation of cells or tissues. Cell culture in general can be applied either to primary cells (e.g., those with a fi nite life span) or to cell lines (e.g., HeLa cells).
    • keywords: ability; acute; adult; agents; agitation; airway; alveolar; ammatory; animal; architecture; ards; asthma; biology; bioreactors; bone; briefl; bronchial; cancer; carcinoma; cell; cell culture; cell lines; cellular; changes; characteristics; characterization; clinical; collagen; colon; component; conditions; confi; culture; culture models; damage; development; differentiation; diffi; dimensional; disease; drug; effects; endothelial; engineering; environment; epithelial; epithelial cells; experimental; explants; exposure; expression; extracellular; factors; fetal; free; function; growth; high; human; immortal; important; individual; infection; infl; injury; interactions; interest; interface; investigators; isolation; large; leighton; like; lines; liquid; lung; lung tissue; mammary; marrow; matrices; matrix; media; medium; membrane; mesenchymal; methods; microcarrier; microgravity; models; monolayer; muscle; need; neoplastic; new; normal; nutrient; organ; particular; pathologic; patients; phenotype; physiology; present; primary; production; prostate; proteins; pulmonary; questions; research; resistance; respiratory; responses; results; role; rotating; rst; salmonella; samples; scale; sclc; serum; signifi; similar; single; small; smooth; specifi; sponge; structures; studies; study; surface; syndrome; systems; techniques; term; threedimensional; tissue; tissue culture; tlas; treatment; tumor; type; unique; use; variables; vessel; virus; vitro; vivo; wall
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70. cord-021744-x320625f
    • author: Thompson, Mark S.
    • title: Systemic Approach to Differential Diagnosis
    • date: 2017-11-17
    • words: 4067
    • flesch: 41
    • summary: Cd (caudodorsal lung region)-same as TFAST CTS view, upper third of the thorax at the level of the eighth to ninth intercostal spaces directly above the xiphoid near the highest point where lung may be visualized on the dorsolateral thoracic wall Ph (perihilar lung region)-sixth to seventh intercostal space, middle third of the thorax Md (middle lung region)-fourth to fifth intercostal space, lower third of the thorax Cr (cranial lung region)-second to third intercostal space GFAST Triad for volume status and patient monitoring GFAST, the name for the use of AFAST and its fluid scoring system, TFAST and Vet BLUE combined, may be used for rapid patient volume status assessment during, before, and after fluid resuscitation • Characterization of CVC and hepatic veins for estimation of CVP (see earlier); forms of shock (e.g., hypovolemic/distributive shock/cardiogenic/obstructive shock) • TFAST-assessment of cardiac views for volume and contractility, right-and left-sided conditions (see TFAST) • Vet BLUE-presence of wet lung screens for left-sided cardiac overload, and the pattern-based approach and Vet BLUE lung ultrasound signs help determine CHF, pneumonia, neoplasia, granulomatous conditions, PTE (pulmonary thromboembolism), and others FAST Ultrasound edited by Gregory R. Lisciandro, DVM, Dipl. Less air interference than TFAST transthoracic PCS views, liver and gallbladder provide acoustic window into thorax • Allows for assessment of volume status by observing dynamics of the caudal vena cava (see DH view in AFAST as an extension of exam).
    • keywords: abdominal; abnormal; acute; afast; afs; air; appearance; aptt; assessment; bleeding; blood; blue; bmbt; cats; caudal; cause; chronic; common; conditions; cts; diagnosis; differential; disease; dogs; effusion; exam; failure; fdp; fluid; gallbladder; heart; hepatic; increase; infection; intercostal; kidney; left; level; line; liver; loss; low; lower; lung; masses; normal; pain; patient; pcv; pericardial; pleural; plt; pneumothorax; point; probe; prostate; proteinuria; pulmonary; renal; retroperitoneal; right; scoring; secondary; severe; sided; sign; site; small; space; surgical; thoracic; trauma; tumors; ultrasound; urine; uroliths; useful; vet; view; volume; wall
    • versions: original; plain text
71. cord-022082-1dq623oe
    • author: Greaves, Peter
    • title: Respiratory Tract
    • date: 2007-09-28
    • words: 19712
    • flesch: 22
    • summary: ^^^ Plasticembedded sections also show the inclusions in other pulmonary cells including pneumocytes attached to the alveolar walls, from which they can be seen discharging into the alveolar spaces. In contrast to findings in people, squamous cell lung tumours are only occasionally seen arising spontaneously in laboratory animals.
    • keywords: accumulation; activity; acute; adenomas; administration; adverse; agents; airborne; airways; alterations; alveolar; alveoli; amiodarone; amphiphilic; analysis; animals; antigen; assessment; associated; balt; basal cells; bleomycin; blood; bodies; body; bronchial; bronchiolar; bronchiolitis; bronchus; cancer; carcinogenicity; carcinoma; cases; cause; cavity; cell hyperplasia; cells; cellular; changes; characterization; chemicals; chronic; ciliated; ciliated cells; clara; clara cells; clearance; clinical; common; complex; conditions; conventional; cuboidal; cytoplasm; damage; degenerative; degree; dense; dependent; development; differences; different; differentiation; diffuse; disease; distribution; dogs; doses; drug; effects; electron; emphysema; enzyme; eosinophilic; epithelial cells; epithelium; evaluation; evidence; examination; example; experimental; exposure; expression; exudate; features; fibrosis; figure; findings; fischer; focal; form; formation; function; glands; goblet; goblet cells; granules; granulomas; granulomatous; growth; hamsters; high; histological; humans; hyperplasia; ii cells; immune; immunocytochemical; important; incidence; inclusions; increase; induced; infections; infiltration; inflammation; inflammatory; inhalation; inhaled; injury; interstitial; intravenous; irritants; laboratory; laboratory animals; large; larynx; layer; lesions; levels; light; like; lining; liver; long; loss; lower; lung; lung tissue; lymphocytes; lymphoid; lysosomal; macrophages; mechanisms; metabolism; metaplasia; mice; microscopic; model; morphological; mouse; mucociliary; mucosa; mucus; nasal; nasal cavity; nasal mucosa; necrosis; neoplasms; neuroendocrine; non; normal; nose; number; oedema; olfactory; olfactory epithelium; olfactory mucosa; oral; organs; p450; parenchyma; particles; particular; pathogens; pathological; pathology; patients; patterns; phospholipidosis; pleural; pneumocystis; pneumonia; pneumonitis; positive; potential; presence; primates; process; proliferative; protein; pulmonary; pulmonary alveolar; pulmonary fibrosis; pulmonary oedema; pulmonary toxicity; range; rats; reactive; receptor; related; respiratory; respiratory epithelium; respiratory tract; response; result; rise; risk; rodents; route; secondary; sections; sendai; sensory; severe; similar; single; size; small; smoke; species; specific; spontaneous; squamous; squamous cell; strain; structures; studies; study; substances; surface; surfactant; sustentacular; sustentacular cells; syndrome; system; term; therapeutic; therapy; tissue; toxicity; toxicology; tracheal; tract; treatment; tumours; type; typical; ultrastructural; upper; useful; variable; variety; vascular; virus; walls; weight; xenobiotics
    • versions: original; plain text
72. cord-022136-3q24qxsr
    • author: Maru, Yoshiro
    • title: Explanation of Metastasis by Homeostatic Inflammation
    • date: 2016-02-02
    • words: 12156
    • flesch: 41
    • summary: key: cord-022136-3q24qxsr authors: Maru, Yoshiro title: Explanation of Metastasis by Homeostatic Inflammation date: 2016-02-02 journal: Inflammation and Metastasis DOI: 10.1007/978-4-431-56024-1_15 sha: doc_id: 22136 cord_uid: 3q24qxsr If inflammation caused by either non-self or self molecules can disseminate throughout the body and inflammatory sites actively allow entry of circulating tumor cells and assist regrowth, then circulating tumor cells metastasize to the sites of inflammation. If inflammation caused by either non-self or self molecules can disseminate throughout the body and inflammatory sites actively allow entry of circulating tumor cells and assist their regrowth, then circulating tumor cells metastasize to the sites of inflammation.
    • keywords: acids; activation; activity; adipose; administration; ahr; amino; analysis; angiogenesis; angiotensin; anti; antibody; arthritis; atf3; atii; b16f10; background; bacteria; bearing; binding; binds; bone; breast; calcineurin; cancer; case; ccl2; ccr2; cd11b; cells; chap; circulation; club; conditions; critical; danger; days; defensive; dependent; development; dscr-1; eet; endogenous; endothelial; endothelial cells; enhanced; ephrin; epithelial; example; experiments; expression; factor; family; fig; form; gene; group; growth; high; homeostatic; human; huvec; il-6; important; increased; induced; inflammation; inflammatory; inhibited; injection; knockout; ko mice; leukocytes; levels; ligands; like; likely; liver; lps; lung metastasis; lungs; macrophages; mammary; manner; marrow; md-2; mdsc; mechanism; melanoma; metastasis; mice; migration; mmtv; model; molecules; monocytes; mouse; myd88; myeloid; negative; neutrophil; nfκb; non; organs; paracrine; patients; peptide; permeability; place; premetastatic; primary; production; proteins; pulmonary; pymt; rage; rankl; receptor; recruitment; regulation; response; results; role; s100a8; saa3; serum; signaling; sites; skin; space; specific; stimulated; stimulation; system; systemic; tail; tissue; tlr4; tnfα; toll; tone; transgenic; tumor; tumor cells; type; vascular; vegf; vein; weeks; wild
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73. cord-023211-kt5gt26t
    • author: None
    • title: Poster Session Abstracts
    • date: 2007-08-29
    • words: 221712
    • flesch: 48
    • summary: Understanding how its modulation modifies transepithelial transport and inflammation in CF versus non CF cells should give new therapeutic clues to reduce exaggerated inflammation and improve fluid secretion in CF patients. This finding indicates that CFTR potentiators have a wide efficacy on many class III mutants and therefore may represent a promising therapeutic strategy for a significant number of CF patients.
    • keywords: 1,2; 16hbe; 2004; a2b; a549; aat; abc; ability; abnormal; abnormalities; abpa; absence; absorption; access; account; accumulation; accurate; acid; acidification; acinar; acinar cells; acquisition; acting; activators; active; activities; acts; acute; addition; address; adenosine; adequate; adherence; adherent; adjusted; administration; admission; ado; adolescents; adult cf; adult cystic; adult patients; adults; advance; adverse; aerosol; aeruginosa; aeruginosa lung; affected; affinity; agar; age; aged; agents; aggressive; agonists; agreement; aim; aims; airflow; airway cells; airway disease; airway epithelial; airway infection; airway inflammation; airway surface; airways; algorithm; allele; alpha; alterations; altered; alternative; alveolar; amikacin; amiloride; amino; aminoglycoside; amounts; anaerobes; anaerobic; analysis; anemia; anemic patients; anion; annual; antibiotic; antibiotic treatment; antibodies; antibody; antimicrobial; antisense; anxiety; apical; application; appointments; approach; appropriate; areas; arikace; array; asl; aspects; aspergillus; assay; assessment; associated; association; asthma; atp; atpase; attention; aureus; australia; available; average; azithromycin; azm; background; bacterial; bal; balance; balf; band; barriers; baseline; basis; basolateral; bath; bcc; beginning; behavior; beneficial; benefit; best; beta; better; bhk cells; bile; binding; biochemical; biofilm; biological; biomarkers; birth; bles; block; blood; blot; bmi; body; bone; breathing; bronchial epithelial; bronchiectasis patients; bronchoalveolar; burden; burkholderia; ca2; cacc; calcium; calls; calu-3; camp; canada; canadian cf; cancer; capable; capacity; carbachol; caregivers; carolina; cascade; cases; categories; caucasian cf; cause; cbavd; cbf; cell lines; cell surface; centers; central; centres; cepacia; cepacia cf; cepacia patients; ceramide; certain; cf ages; cf airway; cf animals; cf association; cf balf; cf boys; cf bronchial; cf bronchiectasis; cf care; cf carrier; cf cases; cf cells; cf center; cf centre; cf children; cf clinic; cf cultures; cf data; cf database; cf diagnosis; cf disease; cf ebv; cf epithelial; cf families; cf family; cf females; cf foundation; cf gene; cf group; cf hbe; cf infants; cf isolates; cf liver; cf lung; cf macrophages; cf mice; cf model; cf mouse; cf mutation; cf nasal; cf nbs; cf neutrophils; cf offspring; cf outcomes; cf pathophysiology; cf patients; cf phenotype; cf phone; cf physician; cf population; cf practitioners; cf program; cf pulmonary; cf quality; cf registry; cf research; cf respiratory; cf samples; cf secretion; cf sputum; cf subjects; cf survival; cf team; cf therapeutics; cf therapies; cf therapy; cf transmembrane; cf treatment; cf trust; cf unit; cf vitamins; cfbe41o; cff; cfft; cfld; cfq; cfrd; cftr; cftr activation; cftr activity; cftr biogenesis; cftr cdna; cftr cell; cftr channel; cftr chloride; cftr correctors; cftr deficient; cftr degradation; cftr dependent; cftr endocytosis; cftr expression; cftr folding; cftr function; cftr gene; cftr genotype; cftr inhibitor; cftr interaction; cftr intracellular; cftr knockout; cftr levels; cftr locus; cftr maturation; cftr mice; cftr mrna; cftr mutations; cftr null; cftr orthologue; cftr potentiators; cftr processing; cftr promoter; cftr protein; cftr regulation; cftr results; cftr sequence; cftr surface; cftr tm1unc; cftr trafficking; cftrinh-172; cfu; challenge; chamber; changes; channel; channel activity; channel function; chapel; chaperones; characteristics; characterized; chart; chemical; chest; chicago; chip; chloramphenicol; cholesterol; chromatography; chronic; chronic lung; chs cf; ciliated; ciliated cells; ciprofloxacin; circuit; classes; classic cf; classified; clchannel; clearance; clinical; clinical data; clinics; clonal; clones; cm2; coated; code; coding; codon; cohort; collagen; collection; colonic; colonization; colonized; combination; combined; commd1; common; common cf; communication; community; comparable; comparison; complete; completion; complex; compliance; complications; component; composition; compounds; concentrations; conclusion; conditions; conductance; configuration; confocal; conformational; consecutive; consecutive patients; consensus; consequences; consistent; constructs; containing; content; continued; contraction; contrast; contribution; control; control cells; control patients; conventional; correctors; correlated; correlation; corresponding; cost; cough; counseling; counts; course; cpg; creatinine; criteria; critical; cross; crp; crucial; csf; csp; cst; cultures; current; cycle; cystic fibrosis; cytochalasin; cytokine; cytoplasmic; cytosolic; daily; damage; data; date; day; days; death; decision; decline; decreased; defect; defective cftr; defense; deferens; deficient; deficient patients; degradation; degree; deletion; delf508 cftr; delivery; delta; deltaf508; density; denufosol; department; dependent; deposition; depression; desensitization; design; detectable; detection; determination; determined; developed; development; deviation; device; df508; dha; diabetes; diabetic; diagnosis; diet; dietary; differences; different; different cf; differential; differentiated; difficult; diminished; direct; discharge; discussion; disease; disruption; distinct; distribution; diverse; dna; dnase; dogs; domain; dominant; dose; dosing; double; downstream; drug; dry; duox; duration; dx-890; dxa; dysfunction; e.g.; earlier; early; ebc; ednra; effect; effective; effectiveness; efficacy; efficiency; efflux; effort; egfr; elastase; electronic; electrophoresis; elements; elevated; elevation; elisa; enac; encoding; endocytic; endogenous; endogenous cftr; endoplasmic; energy; enhanced; entire; entry; environment; enzyme; epidemiology; episodes; epithelial cells; epithelium; eps; equivalent; equol; essential; established; estimate; estrogen; eur-1008; evaluation; events; evidence; exacerbation; example; excessive; exchange; exercise; exhibit; exon; expansion; expected; experienced; experiments; expiratory; export; exposure; expressing; expression levels; extent; extracts; f508del; f508del cftr; factors; failure; families; family; fasting; fat; fatty; features; fed; fev1; fewer; ffm; fibrosis airway; fibrosis center; fibrosis foundation; fibrosis lung; fibrosis patients; fibrosis transmembrane; final; findings; flagellin; flow; fluid; fluorescence; focus; fold; folding; following; food; forms; forskolin; fractions; france; free; french cf; frequency; frequent; frt; frt cells; fumigatus; functional; functioning; fungal; future; fvc; fxyd5; g551d; gain; gamma; gastrointestinal; gastrostomy; gating; gel; gels; gender; gene expression; gene therapy; general; generation; genes; genetic; genistein; genome; genomic; genotype; genotyping; germany; gfp; girls; glands; global; glucose; glutathione; goal; good; gradient; grant; greater; green; groups; growth; gs-9310/11; gsh; guidelines; h2o; half; halide; hand; hbac cftr; hbe; hbe cells; hbecs; hdj-2; health; healthcare; hearing; hela; hela cells; help; heterozygous; high; higher; highest; hill; hispanic cf; hispanic patients; history; hits; hmgb1; home; homeostasis; homozygous; homozygous cf; hospital; hospitalization; host; hours; hrct; hrqol; hrs; hsp70; human airway; human cells; human cf; human lung; human patients; humans; hyperabsorption; hypertonic; hypoglycaemia; hypothesis; hypothesized; hypoxia; i.v; ib3; ib3 cells; ibuprofen; identical; identification; identifying; ige; igg; iii; il-10; il-17a; il-23; il-6; il-8; illness; images; imaging; immature cftr; immune; immunofluorescence; immunoprecipitation; impact; impaired; impairment; important; important cf; improved; improvement; incidence; income; increase; incubated; incubation; index; individuals; induced; induction; infected; infection; inflammation; inflammatory; inflammatory cells; influence; influx; information; inhalation; inhaled; inhibited; inhibition; inhibitors; initial; initiation; injury; innate; inserm; insights; institute; instrument; insufficiency; insulin; insurance; intact; intake; intensity; interaction; interest; interface; interim; intermediate; internal; internalized cftr; intervention; interviews; intestinal; intracellular; intravenous; introduction; investigation; involvement; iodide; irt; isc; isolates; isolation; issues; italian cf; italy; items; jet; junctions; kda; key; killing; kinase; kingdom; knockdown; knowledge; known; laboratories; laboratory; lack; lactate; large; lavage; layer; leading; leads; left; legal; length; lentiviral; levels; levofloxacin; library; life; likely; limited; linear; lines; lipid; liposomal; liposomes; liquid; list; literature; littermates; little; local; localization; localized; london; long; longer; longitudinal; loss; lower; lps; luciferase; lumen; luminal; lung cells; lung disease; lung epithelial; lung function; lung infection; lung inflammation; lung transplant; lungs; lymphoma; magnitude; maintenance; major; major cf; majority; making; malabsorption; male cf; malh; management; mannitol; marked; markers; mass; material; matrix; mature; maximal; maximum; mcc; mdck; mean; mean age; mean fev1; measure; measurements; mechanism; median; mediators; medical; medication; medicine; medium; members; membrane; membrane cftr; membrane expression; metabolism; methods; microbiology; micrornas; microscopy; migration; mild; mild cf; min.gland; mineral; minimal; minutes; missed; missense; mixed; mmol; mmp-8; model; moderate; modest; modifier; molecular; molecule; monitoring; monolayers; months; morbidity; mortality; motif; motility; motor; mouse lung; mp-376; mrna; mrsa; muc4; muc5ac; mucin; mucociliary; mucoid; mucosal; mucous cells; mucus; multicenter; multiple; murine; mutant cftr; mutants; n=10; n=3; n=4; n=5; n=6; n=7; n=9; na+; nacl; nanoparticles; nasal; national; nbd1; nbd2; nbds; nebulization; nebulizer; necessary; need; negative; neonatal; neutrophil; new; new cf; newborn; nherf1; nih; non; non cf; normal; normal cftr; north; novel; npt2a; nthi; nuclear; nucleolin; nucleotide; number; numerous; nutritional; objective; observation; observed; obstruction; ogtt; oil; ongoing; onset; oocytes; open; optimal; oral; order; organisms; outcomes; outpatient; output; overall; overexpression; overnight; oxalate; oxidative; oxygen; p2y; p<0.001; p<0.05; padi; pain; pairs; pancreatic; panel; pao1; parallel; parameters; parental; parents; participants; participation; particular; past; patch; pathogenesis; pathogens; pathology; pathway; patients age; pattern; pbs; pcd; pcn; pcr; pdz; peak; pediatric cf; pediatric patients; pediatrics; peg; people; peptide; percent; percentile; performance; perfusion; period; peritoneal cf; permeability; persistent; pex; pfge; pfts; pge2; pgp; pharmacokinetic; pharmacological; phase; phenotypes; phenylalanine; phosphorylation; physical; physicians; physiological; physiotherapy; picc; pigs; pilot; pka; pkc; placebo; placement; planktonic; plasma; plasmid; play; pmns; point; polarized; polymorphisms; poor; populations; porcine; porcine cftr; positive; positive cells; positive cf; possible; post; potency; potential; pparγ; practice; predominant; pregnancy; pregnant; preliminary; preliminary results; prescribed; presence; present; present study; pretreatment; prevalence; previous; primary; primary cf; prior; probability; probe; problem; procedures; process; processes; processing; production; products; profile; program; progression; project; proliferation; prolonged; prominent; promising; properties; proportion; prospective; prostasin; protease; protein expression; protein levels; proteins; proteolytic; protocol; providers; ps patients; psa; pseudomonas; pseudomonas aeruginosa; pulmonary disease; pulmonary exacerbation; pulmonary function; pulse; pups; purified; purpose; putative; pyocyanin; qds; quality; quantitative; quarterly; questionnaire; questions; raav; rab4; radiation; randomized; range; rapid; rare; rate; ratios; rats; ray; reactions; reactive; reasons; recent; receptor; recipients; recombinant; recommendations; recorded; records; recovery; recruitment; recurrent; recycling; redox; reduced; redundancy; reference; regimens; region; regular; regulated; regulation; regulatory; related; relationship; relative; relaxation; release; relevance; relevant; renal; repeat; reported; reporting; reports; reproductive; rescue; residue; resistance; respect; respondents; response; responsible; results; retention; reticulum; retrospective; review; risk; role; routine; royal; rsv; safety; saline; salt; samples; satisfaction; saturation; scale; scanning; scans; school; sciences; scores; screened; screening; sds; second; secondary; secrete; secretion; secretory; sectional; selective; self; sensitive; sensitivity; separate; sequence; sequencing; serca; series; serosal; serous; serous cells; serum; set; setting; severe; severe cf; severe lung; severity; sex; sft; short; shrinkage; signaling; significant; significant increase; signs; similar; single; sinus; sirna; site; size; skin; slc26a9; sleep; slope; slow; small; smm; snps; social; sodium; software; solids; soluble; solution; source; species; specific; specific cftr; specificity; specimens; spectrometry; spirometry; splicing; spp; stability; stable cf; stable patients; staff; staining; standard; standard cf; standardized; start; state; statistical; status; steady; stem cells; step; stimulated; stimulation; stip-1; stone; strains; strategies; strategy; stress; strong; structure; studies; study; study group; study patients; study period; stx6; submucosal; subsequent; substantial; substrate; subunit; successful; sufficient; suitable; sult1e1; summary; supernatant; supplementation; support; surface; surface expression; surfactant; surgery; survey; survival; susceptibility; sustained; sweat; symptoms; synagis; synergy; synthesis; system; systemic; t84; target; targeted; targeting; techniques; technology; temperature; terminal; terminus; test; tested; testing; tgf; tgfβ; therapeutic; therapies; therapy; thought; throughput; tidal; tight; time; tissue; tlr2; tnfα; tobramycin; tolerance; tolerated; tool; total; total cells; total cftr; toxicity; tracheas; tract; training; transcription; transduced; transduction; transepithelial; transfected; transfer; transgene; transient; transition; transplant; transplant patients; transplantation; transport; transporters; treatment; trend; trials; tube; type cftr; types; ubiquitin; udca; uk cf; unable; unchanged; unclear; underlying; understanding; underwent; unique; united; university; unknown; untreated; upr; uptake; urea; usa; useful; ussing; values; variability; variable; variants; variation; variety; vas; vcp; vector; vehicle; ventilation; vestibular; vip; viral; virulence; virus; viscosity; visits; vitamin; vitro; vivo; voltage; volume; volunteers; voriconazole; waiting; wall; water; weeks; weight; western; wide; wild; wildtype; women; work; worse; wt cells; wt cftr; wt mice; xbp-1s; years; young; young cf; young patients; younger; yrs; zone; ∆264; ∆f508 cftr; ∆f508cftr
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74. cord-023216-avn8f2w3
    • author: None
    • title: Symposium summaries
    • date: 2004-10-18
    • words: 55740
    • flesch: 41
    • summary: The existence of an underlying defect in the airway immune response of CF patients remains controversial; however, increasing evidence suggests that the CF lung exhibits an exaggerated immune response even in the absence of bacterial infection (1;2). In CF patients with mild disease, compared with age-matched normal subjects, a reduced mucociliary clearance has been reported (4).
    • keywords: abdominal; ability; abnormal; abnormalities; absence; absorption; acid; acquisition; acting; activation; active; activities; activity; acute; addition; adenylate; adherence; admissions; adolescents; adp; adults; aeruginosa; affected; age; agents; aggressive; airway; alterations; altered; amino; amp; analysis; anti; antibiotics; anxiety; apical; apoptotic; application; approach; appropriate; areas; asl; assessment; associated; association; atp; atpase; atypical; available; bacterial; basis; bcc; bearing; benefit; best; better; bile; biliary; binding; biochemical; blood; bone; breathing; camp; capacity; carbohydrate; care; cases; cause; cells; cellular; center; cepacia; cf airway; cf care; cf cells; cf center; cf diagnosis; cf disease; cf foundation; cf gene; cf hae; cf infants; cf lung; cf mice; cf mutation; cf newborn; cf patients; cf phenotype; cf respiratory; cf study; cfld; cfrd; cftr; cftr chloride; cftr expression; cftr function; cftr gene; cftr mutations; cftr protein; changes; channel; chest; children; chloride; chronic; chronic pain; ciliated; cirrhosis; clearance; clinical; combination; common; compared; complete; complex; complications; components; concentrations; concerns; conditions; conductance; consensus; consequences; consistent; content; contrast; control; core; correctors; correlation; cough; course; criteria; critical; culture; current; cystic fibrosis; cytokines; data; day; death; decision; decline; decreased; defect; defective; defense; deficiency; degree; delayed; delivery; density; dependent; development; diabetes; diabetic; diagnosis; diet; differences; different; difficult; discovery; disease; dna; domain; dose; drug; dysfunction; early; effective; effects; efficacy; efforts; elevated; end; energy; environment; epithelial; epithelial cells; essential; established; evidence; example; exercise; experience; exposure; expression; factors; failure; families; family; fat; features; fev; fibrosis patients; findings; fluid; focused; folding; follow; foundation; frequency; frequent; function; gain; gating; gene; general; genetic; genome; genotype; gentamicin; gland; glandular; glucose; goal; good; greater; groups; growth; guidelines; health; healthcare; help; hepatic; high; higher; hospital; host; hpiv; hrqol; human; human cftr; hyperglycemia; hypertension; hypnosis; hypothesis; identification; ikk; il-8; illness; imaging; immune; impact; impaired; important; improved; improvement; incidence; increase; increasing; individual; induced; infants; infection; inflammation; inflammatory; influence; information; inhibition; inhibitors; initial; injury; innate; insulin; intake; intensity; interactions; interventions; intestinal; invasive; involved; key; kinase; knowledge; known; lack; large; lead; levels; life; likely; limited; liquid; list; little; liver; liver disease; living; long; loss; lower; lung disease; lung function; lungs; major; majority; management; mass; matrix; measurements; measures; mechanisms; median; medical; members; membrane; metabolism; method; mice; mild; model; modifier; molecular; molecules; morbidity; mortality; mouse; mucociliary; mucus; multiple; muscle; mutant; mutant cftr; mutations; nasal; nature; nbd1; nbd2; necessary; need; negative; neonatal; neutrophil; newborn; non; nonsense; normal; normal cftr; novel; nucleotide; number; nutritional; observations; observed; obstruction; occur; open; opening; opportunity; optimal; oral; order; organ; outcomes; overall; pain; pancreatic; parents; particular; past; pathogenesis; pathogens; pathology; pathway; patterns; pediatric; people; performance; person; phenotype; phosphorylation; physical; physiotherapy; pip; pkc; poor; population; portal; positive; possible; post; potential; practice; presence; present; prevalence; previous; primary; prior; problems; process; processes; processing; production; program; progression; properties; protein; providers; pseudomonas; psychological; pulmonary; pump; quality; range; rapid; rate; recent; receptor; recognition; reduced; registry; regulation; related; relationship; reported; reports; rescue; research; residual; resistance; respiratory; response; results; review; risk; role; screening; second; secretion; secretory; self; sensitive; sensitivity; serous; serum; severe; severity; short; siblings; signaling; significant; similar; single; site; small; sodium; species; specific; specificity; spectrum; sputum; stable; state; status; stellate; stimulation; story; strains; strategies; strategy; stress; structure; studies; study; subjects; sufficient; summary; support; surface; survival; sweat; symptoms; system; team; term; test; testing; therapeutic; therapies; therapy; time; tissue; tnf; tolerance; tract; transcript; transfer; transmembrane; transplant; transplantation; transport; treatment; trial; twins; type; understanding; unique; use; useful; values; variability; variation; variety; vectors; ventilation; viral; vitro; vivo; volume; waiting; water; weight; wide; wild; women; work; years; young; ∆508; ∆f508; ∆f508 cftr
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75. cord-023239-06a03o14
    • author: None
    • title: II. Topic Sessions
    • date: 2016-06-10
    • words: 33484
    • flesch: 34
    • summary: Several studies reported an association of preterm birth (30-36 weeks' GA) without clinical lung disease with altered lung development and function [2] . The Size and Lung function In Children (SLIC) study was designed to improve normative reference ranges for lung function by taking differences in body physique into account to facilitate early diagnosis and treatment of lung disease in all children, irrespective of ethnic background 7 .
    • keywords: abnormal; acetylcholine; activation; activity; acute; addition; adenotonsillectomy; administration; adolescents; adults; age; aged; agents; airway; allergic; allergy; altered; alternative; analysis; antibiotic; anticholinergic; apnea; approach; appropriate; assessment; association; asthma; asthma control; available; bacterial; better; birth; body; bpd; breathing; bromide; bronchial; bronchiectasis; bronchopulmonary; care; case; cdhr3; cells; center; central; cf patients; cftr; changes; chest; childhood; childhood asthma; children; chronic; ciliary; class; clearance; clinical; cohort; collapse; combination; common; conditions; consensus; control; copd; countries; criteria; critical; cystic; cystic fibrosis; data; decrease; delivery; detection; development; diagnosis; differences; different; difficult; disease; disorders; dose; dynamic; dysfunction; dyskinesia; dysplasia; early; effect; effective; efficacy; endotracheal; environmental; epithelial; equations; ethnic; ethnicity; etiology; european; evidence; evolution; exacerbations; example; exposure; expression; factors; features; fev; fibrosis; findings; flow; follow; following; function; future; fvc; gas; gene; general; genetic; genome; gli; global; group; growth; guidelines; gwas; health; height; heterogeneous; high; higher; host; human; ics; imaging; immune; impaired; important; improved; improvement; incidence; increase; index; individual; induced; infants; infection; inflammation; inflammatory; influence; information; inhaled; initial; intermittent; interpretation; intubation; ipratropium; lack; large; later; levels; life; likely; limited; loci; locus; long; longer; longitudinal; low; lower; lung; lung disease; lung function; maintenance; major; majority; management; maternal; measures; mechanical; mechanisms; medication; medicine; meta; methods; mice; microbes; microbiome; mild; models; moderate; months; morbidity; mortality; mri; mucus; multiple; muscarinic; muscle; mutations; nasal; ncpap; need; neonatal; nerve; new; newborn; nippv; non; normal; novel; number; obesity; observed; obstructive; odds; onset; organisms; osas; osdb; outcomes; overall; overlap; pancreatic; pathogenesis; pathogens; patients; pcd; pediatric; performance; period; persistent; phenotype; pneumonia; poor; population; positive; possible; post; potential; practice; premature; prematurity; preschool; preschool children; present; pressure; preterm; prevalence; prevention; primary; problems; production; proportion; prospective; protein; pulmonary; pulmonary function; quality; radiation; randomized; range; rapid; rate; rds; recent; receptors; recurrent; reference; related; relationship; release; remodeling; report; research; resistance; respiratory; response; results; review; rhinovirus; risk; role; routine; rsv; screening; severe; severe asthma; severity; short; significant; similar; single; size; sleep; small; smooth; snoring; society; specific; specificity; spirometry; sputum; standard; statistical; steroids; strategies; strategy; strong; structural; studies; study; subjects; support; surfactant; susceptibility; symptoms; syndrome; systematic; technique; term; testing; therapeutic; therapies; therapy; tidal; time; tiotropium; tracheobronchomalacia; treatment; trial; tuberculosis; underlying; understanding; upper; use; utility; values; vascular; ventilation; viral; virus; viruses; volume; weeks; wheeze; wheezing; wide; years; young; young children
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76. cord-023288-sqr33y72
    • author: None
    • title: Paediatric SIG: Poster Session
    • date: 2008-03-12
    • words: 30188
    • flesch: 50
    • summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients.
    • keywords: 6mwd; ability; action; activity; acute; additional; adults; aeruginosa; age; aged; ahr; aim; airway; alexithymia; allergic; alternative; analysis; anti; apoptosis; area; artpah; asm; asm cells; assay; assessment; associated; association; asthma; asthma control; asthma patients; asthmatics; australia; azithromycin; background; bal; balb; baseline; best; biopsy; birth; blood; breathing; bronchial; bronchiectasis; cancer; capacity; care; cases; cat; cause; cells; challenge; changes; characteristics; chest; childhood; children; chronic; clearance; clinical; cohort; collagen; combination; combined; common; complete; conclusions; control; copd; copd patients; correlation; corticosteroids; cough; cpap; current; current asthma; cytokines; data; days; dcs; department; development; diagnosis; diaries; difference; disease; donors; dose; early; ebc; effect; elisa; emphysema; epithelial; events; evidence; exacerbations; exercise; exposure; expression; factors; family; fat; features; female; fev1; fibronectin; fibrosis; findings; flow; fold; follow; fot; frequency; function; gene; general; gord; gp130; gps; granzyme; group; growth; health; hfd; high; higher; history; hospital; hrct; human; hypertension; ige; il-6; il-8; immune; impact; important; improved; improvement; incidence; increased; independent; index; individuals; induced; infection; inflammation; inflammatory; influence; inhaled; initial; interstitial; intervention; introduction; isolated; large; length; levels; life; likely; long; lower; lung; lung cancer; lung disease; lung function; major; male; management; mannitol; markers; mean; measured; mechanism; median; medical; medication; mesothelin; methods; mice; model; monocyte; months; morbidity; morning; mrna; muscle; n =; nhmrc; nod; non; normal; nsw; number; obstructive; osa; outcomes; p =; parameters; participants; pathway; patients; pcr; peak; people; period; persistent; phagocytic; pleural; pm10; poor; population; positive; post; potential; practice; predictors; pregnancy; presence; presentation; prevalence; previous; primary; prior; problems; process; production; program; protein; pulmonary; quality; questionnaire; randomized; range; rate; recent; receptor; recruitment; recurrent; reduced; relationship; release; remodelling; research; resistance; respiratory; response; results; reversibility; review; right; risk; role; samples; scid; score; screening; second; secondary; sem; sensitivity; sensitization; serum; severe; severity; significant; similar; single; sleep; smokers; smoking; smooth; specific; spirometry; sputum; stage; standard; stimulated; studies; study; subjects; support; surgery; symptoms; system; technique; test; testing; th1; therapy; tidal; time; tissue; total; training; treatment; trend; trials; tuberculosis; tumour; tumstatin; underwent; unknown; use; ventilation; viral; vitro; volume; weeks; wheeze; wks; women; years; yrs
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77. cord-023303-fxus38mp
    • author: None
    • title: Lung Cancer/Bronchology SIGs: Combined Poster Session
    • date: 2008-03-12
    • words: 30191
    • flesch: 50
    • summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients.
    • keywords: 6mwd; ability; action; activity; acute; additional; adults; aeruginosa; age; aged; ahr; aim; airway; alexithymia; allergic; alternative; analysis; anti; apoptosis; area; artpah; asm; asm cells; assay; assessment; associated; association; asthma; asthma control; asthma patients; asthmatics; australia; azithromycin; background; bal; balb; baseline; best; biopsy; birth; blood; breathing; bronchial; bronchiectasis; cancer; capacity; care; cases; cat; cause; cells; challenge; changes; characteristics; chest; childhood; children; chronic; clearance; clinical; cohort; collagen; combination; combined; common; complete; conclusions; control; copd; copd patients; correlation; corticosteroids; cough; cpap; current; current asthma; cytokines; data; days; dcs; department; development; diagnosis; diaries; difference; disease; donors; dose; early; ebc; effect; elisa; emphysema; epithelial; events; evidence; exacerbations; exercise; exposure; expression; factors; family; fat; features; female; fev1; fibronectin; fibrosis; findings; flow; fold; follow; fot; frequency; function; gene; general; gord; gp130; gps; granzyme; group; growth; health; hfd; high; higher; history; hospital; hrct; human; hypertension; ige; il-6; il-8; immune; impact; important; improved; improvement; incidence; increased; independent; index; individuals; induced; infection; inflammation; inflammatory; influence; inhaled; initial; interstitial; intervention; introduction; isolated; large; length; levels; life; likely; long; lower; lung; lung cancer; lung disease; lung function; major; male; management; mannitol; markers; mean; measured; mechanism; median; medical; medication; mesothelin; methods; mice; model; monocyte; months; morbidity; morning; mrna; muscle; n =; nhmrc; nod; non; normal; nsw; number; obstructive; osa; outcomes; p =; parameters; participants; pathway; patients; pcr; peak; people; period; persistent; phagocytic; pleural; pm10; poor; population; positive; post; potential; practice; predictors; pregnancy; presence; presentation; prevalence; previous; primary; prior; problems; process; production; program; protein; pulmonary; quality; questionnaire; randomized; range; rate; recent; receptor; recruitment; recurrent; reduced; relationship; release; remodelling; research; resistance; respiratory; response; results; reversibility; review; right; risk; role; samples; scid; score; screening; second; secondary; sem; sensitivity; sensitization; serum; severe; severity; significant; similar; single; sleep; smokers; smoking; smooth; specific; spirometry; sputum; stage; standard; stimulated; studies; study; subjects; support; surgery; symptoms; system; technique; test; testing; th1; therapy; tidal; time; tissue; total; training; treatment; trend; trials; tuberculosis; tumour; tumstatin; underwent; unknown; use; ventilation; viral; vitro; volume; weeks; wheeze; wks; women; years; yrs
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78. cord-023306-3gdfo6vd
    • author: None
    • title: TSANZ Oral Abstracts
    • date: 2010-03-01
    • words: 23408
    • flesch: 50
    • summary: This prospective study confirms the risk status assigned by the LCSS with 41 (6%) vs. 11 (2%) lung cancers over the 5 year follow up (OR = 2.6 (%% CI 1.3-5.4, p = 0.005).The performance characteristics of the LCSS reported here, confirm its utility, in correctly identifying smokers at greatest lung cancer risk. In the Indigenous Australian setting the SGRQ total score was independently associated with exacerbation frequency and lung function (% predicted FEV1) whilst the symptom score was associated more strongly with AE frequency and activity score with lung function.
    • keywords: 6mwd; activity; adherence; adult; age; aged; ahr; aim; aims; airway; alri; analysis; anti; aoct; asbestos; assessment; associated; asthma; asthmatics; atopic; australia; background; bal; baseline; benefit; birth; blood; bos; bronchiectasis; cancer; capacity; care; cases; cdad; cells; centres; cf patients; challenge; changes; chest; childhood; children; chronic; clinical; clonal; cohort; collagen; common; community; conclusion; conflict; control; copd; cough; cse; ctpa; culture; current; cystic; cytokine; daily; data; days; decreased; deficiency; department; determined; development; diagnosis; difference; disease; distensibility; dose; dyspnea; early; effect; electronic; emphysema; epithelial; eradication; evidence; exercise; exposure; expression; factor; family; feno; fev; fev1; fibrosis; findings; following; frequency; function; fvc; gag; gene; gp130; gps; group; growth; gsh; healthy; high; higher; history; hmc-1a; hospital; hours; human; ifn; iga; ige; igg; il-17a; il-6; immune; impaired; important; improved; improvement; incidence; increase; infection; inflammation; inflammatory; influenza; inhaled; interest; intervention; introduction; levels; life; local; low; lower; lung; lung function; macrophage; major; management; markers; massive; maternal; mbl; mean; measures; median; medical; medication; mesothelioma; methods; mice; minute; model; monitoring; months; mortality; mrna; n =; new; nhmrc; nil; nomination; non; normal; nox2; number; obstructive; outcomes; oxygen; pal; paracetamol; parameters; participants; pathway; patients; peak; people; period; plasma; poor; positive; post; potential; predictors; pregnancy; pregnant; preterm; prevalence; primary; prior; production; program; proliferation; prospective; protein; pulmonary; quality; questionnaire; ra+; randomised; range; reduced; reflex; regulation; rehabilitation; release; repair; respiratory; response; results; review; risk; role; samples; scans; score; screening; sec; severe; significant; similar; small; smokers; smoking; smr; spacer; specific; spirometry; sputum; stage; status; strains; studies; study; subjects; support; swallow; symptoms; technique; term; test; tgfb; time; tissue; total; transplant; transplantation; trapping; treatment; type; use; useful; ventilation; viruses; volume; walk; weight; women; years; young
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79. cord-023308-af5nihyi
    • author: None
    • title: COPD SIG: Poster Session 2
    • date: 2008-03-12
    • words: 30189
    • flesch: 50
    • summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients.
    • keywords: 6mwd; ability; action; activity; acute; additional; adults; aeruginosa; age; aged; ahr; aim; airway; alexithymia; allergic; alternative; analysis; anti; apoptosis; area; artpah; asm; asm cells; assay; assessment; associated; association; asthma; asthma control; asthma patients; asthmatics; australia; azithromycin; background; bal; balb; baseline; best; biopsy; birth; blood; breathing; bronchial; bronchiectasis; cancer; capacity; care; cases; cat; cause; cells; challenge; changes; characteristics; chest; childhood; children; chronic; clearance; clinical; cohort; collagen; combination; combined; common; complete; conclusions; control; copd; copd patients; correlation; corticosteroids; cough; cpap; current; current asthma; cytokines; data; days; dcs; department; development; diagnosis; diaries; difference; disease; donors; dose; early; ebc; effect; elisa; emphysema; epithelial; events; evidence; exacerbations; exercise; exposure; expression; factors; family; fat; features; female; fev1; fibronectin; fibrosis; findings; flow; fold; follow; fot; frequency; function; gene; general; gord; gp130; gps; granzyme; group; growth; health; hfd; high; higher; history; hospital; hrct; human; hypertension; ige; il-6; il-8; immune; impact; important; improved; improvement; incidence; increased; independent; index; individuals; induced; infection; inflammation; inflammatory; influence; inhaled; initial; interstitial; intervention; introduction; isolated; large; length; levels; life; likely; long; lower; lung; lung cancer; lung disease; lung function; major; male; management; mannitol; markers; mean; measured; mechanism; median; medical; medication; mesothelin; methods; mice; model; monocyte; months; morbidity; morning; mrna; muscle; n =; nhmrc; nod; non; normal; nsw; number; obstructive; osa; outcomes; p =; parameters; participants; pathway; patients; pcr; peak; people; period; persistent; phagocytic; pleural; pm10; poor; population; positive; post; potential; practice; predictors; pregnancy; presence; presentation; prevalence; previous; primary; prior; problems; process; production; program; protein; pulmonary; quality; questionnaire; randomized; range; rate; recent; receptor; recruitment; recurrent; reduced; relationship; release; remodelling; research; resistance; respiratory; response; results; reversibility; review; right; risk; role; samples; scid; score; screening; second; secondary; sem; sensitivity; sensitization; serum; severe; severity; significant; similar; single; sleep; smokers; smoking; smooth; specific; spirometry; sputum; stage; standard; stimulated; studies; study; subjects; support; surgery; symptoms; system; technique; test; testing; th1; therapy; tidal; time; tissue; total; training; treatment; trend; trials; tuberculosis; tumour; tumstatin; underwent; unknown; use; ventilation; viral; vitro; volume; weeks; wheeze; wks; women; years; yrs
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80. cord-023311-7wqdlha4
    • author: None
    • title: Oral Session
    • date: 2010-11-24
    • words: 17283
    • flesch: 47
    • summary: Conclusion Depression and anxiety were also found in lung cancer patients and need further evaluation and attention from clinician. Methods Patients with medically inoperable or unresectable single nodule NSCLC underwent treatments, in 3 different centers of Bangladesh.
    • keywords: 0.001; active; acute; administration; adult; age; aged; airway; allergic; ammation; analysis; arsenic; asmc; association; asthma; asthmatics; average; bacterial; bangladesh; beroptic; blood; breathing; bronchial; bronchiectasis; bronchoscopy; brosis; bubbles; cancer; cap; care; cases; cell; chest; children; chronic; ciclesonide; city; classifi; clinical; common; community; complications; conclusion; confi; congenital; contacts; control; copd; copd patients; correlation; cpfe; cpg; criteria; culture; cvb; data; day; days; death; defi; development; diagnosis; difference; disease; disorder; drug; duration; effective; emphysema; emt; epithelial; evaluation; exacerbation; exercise; expression; factors; female; frequency; function; gauge; greater; group; gvpla2; hap; heart; high; higher; hospital; human; icu; identifi; important; index; induction; infection; infl; inhalation; initial; insomnia; introduction; january; left; lesions; levels; local; lower; lung; major; male; malignancy; management; mass; mean; median; medical; methods; mice; model; mometasone; months; mortality; muscle; myostatin; ndings; ned; needle; negative; non; normal; number; obstructive; odds; open; outcome; overall; p =; patients; people; perception; pleurodesis; pneumonia; positive; post; present; prevalence; primary; protocol; pulmonary; questionnaire; range; rate; ratio; refl; regression; resistance; respiratory; results; rfa; rhinitis; risk; role; sample; score; sensitivity; serum; severe; severity; signifi; similar; size; skin; sleep; small; smear; snoring; sod; specifi; specimens; sputum; status; stay; studies; study; subjects; surgery; survival; symptoms; systemic; test; therapy; tissue; total; treatment; tuberculosis; tumor; underwent; use; value; virtual; years
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81. cord-023331-jrvmgnu3
    • author: None
    • title: Asthma & Allergy SIG: Poster Session 3. Physiology, Environment, Investigation and Management
    • date: 2008-03-12
    • words: 30195
    • flesch: 50
    • summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients.
    • keywords: 6mwd; ability; action; activity; acute; additional; adults; aeruginosa; age; aged; ahr; aim; airway; alexithymia; allergic; alternative; analysis; anti; apoptosis; area; artpah; asm; asm cells; assay; assessment; associated; association; asthma; asthma control; asthma patients; asthmatics; australia; azithromycin; background; bal; balb; baseline; best; biopsy; birth; blood; breathing; bronchial; bronchiectasis; cancer; capacity; care; cases; cat; cause; cells; challenge; changes; characteristics; chest; childhood; children; chronic; clearance; clinical; cohort; collagen; combination; combined; common; complete; conclusions; control; copd; copd patients; correlation; corticosteroids; cough; cpap; current; current asthma; cytokines; data; days; dcs; department; development; diagnosis; diaries; difference; disease; donors; dose; early; ebc; effect; elisa; emphysema; epithelial; events; evidence; exacerbations; exercise; exposure; expression; factors; family; fat; features; female; fev1; fibronectin; fibrosis; findings; flow; fold; follow; fot; frequency; function; gene; general; gord; gp130; gps; granzyme; group; growth; health; hfd; high; higher; history; hospital; hrct; human; hypertension; ige; il-6; il-8; immune; impact; important; improved; improvement; incidence; increased; independent; index; individuals; induced; infection; inflammation; inflammatory; influence; inhaled; initial; interstitial; intervention; introduction; isolated; large; length; levels; life; likely; long; lower; lung; lung cancer; lung disease; lung function; major; male; management; mannitol; markers; mean; measured; mechanism; median; medical; medication; mesothelin; methods; mice; model; monocyte; months; morbidity; morning; mrna; muscle; n =; nhmrc; nod; non; normal; nsw; number; obstructive; osa; outcomes; p =; parameters; participants; pathway; patients; pcr; peak; people; period; persistent; phagocytic; pleural; pm10; poor; population; positive; post; potential; practice; predictors; pregnancy; presence; presentation; prevalence; previous; primary; prior; problems; process; production; program; protein; pulmonary; quality; questionnaire; randomized; range; rate; recent; receptor; recruitment; recurrent; reduced; relationship; release; remodelling; research; resistance; respiratory; response; results; reversibility; review; right; risk; role; samples; scid; score; screening; second; secondary; sem; sensitivity; sensitization; serum; severe; severity; significant; similar; single; sleep; smokers; smoking; smooth; specific; spirometry; sputum; stage; standard; stimulated; studies; study; subjects; support; surgery; symptoms; system; technique; test; testing; th1; therapy; tidal; time; tissue; total; training; treatment; trend; trials; tuberculosis; tumour; tumstatin; underwent; unknown; use; ventilation; viral; vitro; volume; weeks; wheeze; wks; women; years; yrs
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82. cord-023509-tvqpv6fp
    • author: Corrin, Bryan
    • title: Occupational, environmental and iatrogenic lung disease
    • date: 2011-03-02
    • words: 42595
    • flesch: 39
    • summary: Aluminium powder holds a paradoxical position in regard to lung disease. 366 More directly, welders may be exposed to asbestos insulation that they themselves use, while welders of special steel alloys run the risk of metal-induced asthma, metal fume fever, polymer fume fever and the consequences of toxic metal fume inhalation, 367 all of which are described separately in this chapter, as is lung disease in aluminium welders.
    • keywords: accidental; acid; active; activity; acute; acute lung; acute pulmonary; adjacent; adverse; affected; agents; air; airways; allergic; altitude; altitude pulmonary; aluminium; alveolar; alveolar damage; alveolar epithelial; alveolar fibrosis; alveolar macrophages; alveoli; alveolitis; amiodarone; amosite; amounts; amphibole; amphibole asbestos; analysis; analytical; animal; antibodies; appearances; areas; arteries; artery; asbestos; asbestos asbestos; asbestos bodies; asbestos dust; asbestos exposure; asbestos fibres; asbestos workers; asphyxia; aspiration; associated; association; asthma; atomic; attributable; autopsy; barium; basis; berylliosis; beryllium; beryllium disease; biopsy; birefringent; black; blast; bleomycin; blood; bodies; body; box; bronchial; bronchioles; bronchiolitis; bronchitis; bronchoalveolar; burden; byssinosis; carbon; carcinoma; cardiac; cases; cause; cells; central; centriacinar; certain; changes; characteristic; chemical; chest; chloride; chronic; chrysotile; cigarette; clearance; clinical; coal; coal pneumoconiosis; coal workers; coalminers; coated; cobalt; cocaine; collagen; collapse; combined; common; complicated; complications; compounds; concentrations; condition; consist; content; contrast; correlation; cotton; cough; countries; counts; course; criteria; crystalline; crystals; cytotoxic; damage; dangerous; days; death; degree; dependent; deposition; described; desquamative; development; diagnosis; diameter; different; diffuse; diffuse alveolar; diffuse interstitial; dioxide; diseases; distress; distribution; dose; drowning; drug; dry; dust; dust exposure; dust particles; dust pneumoconiosis; e.g.; early; earth; effects; electron; embolism; emphysema; eosinophilia; epithelial; evidence; evident; example; exogenous; experimental; exposure; extrinsic; factor; failure; fatal; features; fever; fibres; fibrogenic; fibrotic; fibrous; fig; filler; findings; fine; fluid; focal; follow; foreign; form; free; fume; function; gas; general; granulomas; granulomatous; greater; growth; haemorrhage; hard; health; heart; heavy; high; hilar; histological; human; human lung; humidifier; hyaline; hypersensitivity; hypoxia; idiopathic pulmonary; illness; immune; immunological; important; incidence; increase; individual; industrial; industry; inert; infection; inflammation; inflammatory; ingested; ingestion; inhalation; inhaled; injuries; interstitial; interstitial fibrosis; interstitial lung; interstitial pneumonia; interstitial pulmonary; intravenous; iron; irritant; known; laboratory; large; lavage; lead; left; length; lesions; levels; liable; light; likely; lipid; liquid; literature; little; liver; lobes; long; longer; loss; lower; lung; lung asbestos; lung cancer; lung damage; lung disease; lung dust; lung fibrosis; lung function; lung injury; lung pulmonary; lung tissue; lymph; macrophages; major; manufacture; marijuana; marked; marrow; massive; massive fibrosis; material; mechanisms; medical; membranes; mesothelioma; metal; microprobe; microscopy; mineral; mineral dust; miners; mining; mixed; molecular; months; mortality; mountain; myalgia; natural; near; necessary; necrosis; new; nitrogen; nodes; nodules; non; normal; number; obliterans; obliterative; observations; obstructive; occupational; oedema; oil; onset; opacities; organic; organising; oxygen; ozone; page; pain; paraffin; paraquat; particles; particular; parts; pathogenesis; pathological; pathology; patients; pattern; people; period; pleural; pneumoconiosis; pneumonia; pneumonitis; pneumothorax; poisoning; pollution; population; positive; postpneumonectomy; powder; presence; present; pressure; principal; process; production; progressive; prolonged; protein; pulmonary; pulmonary alveolar; pulmonary arteries; pulmonary changes; pulmonary damage; pulmonary disease; pulmonary fibrosis; pulmonary function; pulmonary hypertension; pulmonary oedema; pulmonary toxicity; pure; radiation; radicals; radiological; range; rank; rapid; rare; rat lung; rats; ray; reaction; related; relation; relationship; release; report; respiratory; respiratory disease; response; responsible; result; review; rheumatoid; rich; risk; rock; role; sarcoidosis; sections; severe; short; sickness; silica; silica particles; silicates; siliceous; silicosis; silicotic; similar; simple; size; skin; small; smokers; smoking; space; specific; stenosis; structure; studies; study; substances; surface; symptoms; syndrome; syndrome pulmonary; systemic; table; talc; technique; term; test; therapy; time; tissue; tobacco; total; toxicity; tracheal; tract; trade; transplantation; treatment; tryptophan; tuberculosis; tumour; type; uncoated; unusual; upper; variety; ventilation; vessels; vitro; walls; water; welders; widespread; workers; world; years
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83. cord-024141-9sdbhw2g
    • author: Liu, Haiyan
    • title: Lung and Mediastinum
    • date: 2017-09-02
    • words: 7367
    • flesch: 38
    • summary: histologic subtype other than a lepidic pattern; tumor cells infiltrating myofibroblastic stroma. • Speckled nuclear positivity in more than 50% of tumor cells with NUT antibody is a constant finding and is diagnostic.
    • keywords: abundant; adc; adcs; atypical; background; basaloid; biopsies; cancer; carcinomas; cases; cell; cell carcinomas; cell tumors; cellular; chest; chromatin; chromogranin; classification; clinical; common; cytological; cytology; cytoplasm; diagnosis; differential; differentiation; diffuse; epithelial; expression; features; fig; findings; fine; fna; focal; gata3; gene; giant; grade; granular; growth; high; hyperchromatic; images; immature; immunohistochemical; index; large; lesion; like; lung; lymphocytes; macrophages; malignant; markers; mass; mediastinum; melanoma; membrane; metastatic; mimic; mitoses; mucinous; multiple; necessary; necrosis; negative; neural; neuroendocrine; nonkeratinizing; nuclear; nuclei; nucleoli; p40; p63; patients; pattern; pleura; pneumocytes; positive; positivity; primary; prominent; pulmonary; rare; reactive; representative; representative images; respiratory; s100; sars; single; small; small cell; smears; sox10; specific; specimens; spindle; squamous; squamous cell; synaptophysin; syndrome; table; thymic; thymoma; tissue; transcription; ttf1; tumors; type; urothelial; viral
    • versions: original; plain text
84. cord-024183-1mrdjc39
    • author: Hutchison, Alastair A.
    • title: The Respiratory System
    • date: 2013-10-08
    • words: 28100
    • flesch: 39
    • summary: and Flow/Volume Control In adult humans the glottis opens maximally during inspiration, closes gradually to a minimum about three quarters through expiration, and then opens again in late expiration (England et al. 1982a ). (From O'Connor, D. Reproduced with permission from Myer et al.
    • keywords: abnormalities; absence; active; activities; activity; acute; adolescents; adulthood; adults; age; airflow; airway; airway function; airway obstruction; airway resistance; airway volume; alveolar; analysis; antenatal; apnea; applied; ards; assessment; asthma; asthmatic; atrophy; baraldi; birth; body; bpd; breathing; bronchial; bronchiolitis; bronchopulmonary; cage; capacity; central; changes; chest; chest wall; childhood; children; chronic; chronic lung; clinical; closure; compliance; constant; contribution; control; cough; course; curve; cystic; data; decline; decrease; defect; degree; dependence; development; diaphragmatic; differences; different; disease; disorders; distress; dmd; drive; duchenne; dynamic; dysplasia; dystrophy; early; ecmo; editorial; effect; elastance; elevated; end; et al; evidence; evident; exchange; expiration; expiratory flow; factors; failure; fef; fetal; fev; fibrosis; fig; flow; following; frc; frequency; function; fvc; gas; glottic; group; growth; healthy; hfov; high; higher; humans; hutchison; hypercapnia; hyperinflation; hypoxemia; hypoxia; idiopathic; impact; impaired; impairment; impedance; important; improvement; increase; infancy; infants; influence; initial; injury; inputs; inspiration; interstitial; lambs; laryngeal; later; life; likely; limitation; long; longitudinal; loss; lower; lung; lung compliance; lung disease; lung function; lung mechanics; lung volume; major; mas; maximal; maximum; mean; measurements; measures; mechanics; meconium; mild; months; motor; muscle; muscular; nasal; neonatal; neonates; neuromuscular; newborn; normal; nose; obesity; obstruction; occlusion; onset; opening; oral; osa; outcome; oxygenation; passive; patency; patients; pattern; peak; pediatric; period; peripheral; persistent; phase; physiology; pillow; pimax; positive; postnatal; predicted; premature; preschool; pressure; preterm; preterm infants; progression; properties; protection; pulmonary; pulmonary function; pump; range; rapid; rate; ratio; recoil; recruitment; reduced; reduction; reflex; relationship; relative; reported; residual; resistance; respiratory; respiratory distress; respiratory function; respiratory mechanics; respiratory muscle; respiratory system; response; restrictive; results; risk; scoliosis; secondary; sect; severe; severity; similar; size; sleep; small; society; specific; spinal; spirometry; spoel; state; strength; studies; study; subglottic; subjects; support; surfactant; survivors; swallowing; symptoms; syndrome; system; technique; testing; tests; thach; therapy; thoracic; tidal; time; tissue; tlc; total; transplantation; treatment; type; upper; upper airway; values; ventilation; ventilatory; vital; volume; wall; weakness; weeks; weight; wheezing; years; young
    • versions: original; plain text
85. cord-026005-f2khcjdy
    • author: López, Alfonso
    • title: Respiratory System, Mediastinum, and Pleurae
    • date: 2017-02-17
    • words: 57351
    • flesch: 32
    • summary: Lung disease can have profound systemic effects when cytokines, produced locally during necrosis or inflammation, are released into circulation. Alveolar filling disorders are a heterogeneous group of lung diseases characterized by accumulation of various chemical compounds in the alveolar lumens.
    • keywords: abnormal; abortion; abscesses; abundant; accumulation; acute; addition; adenovirus; adhesions; adult; aerogenous; affected; agents; air; airway; allergic; alveolar; alveolar capillaries; alveolar edema; alveolar injury; alveolar macrophages; alveolar walls; alveoli; alveolitis; amounts; animals; anomalies; antigen; appearance; ards; areas; aspiration; aspiration pneumonia; associated; atelectasis; atrophic; atrophy; bacterial; bacterial pneumonia; barrier; basement; beings; blood; bodies; body; bone; bordetella; bovine; bovis; brain; bronchi; bronchial; bronchiectasis; bronchiolar; bronchiolitis; bronchiseptica; bronchitis; bronchointerstitial; bronchopneumonia; calcification; calves; canine; capillaries; capillary; carcinoma; cases; catarrhal; cats; cattle; caudal; cause; cavity; cells; cellular; changes; chapter; characterized; chronic; ciliated; clearance; clinical; club; coli; collapse; color; common; complex; complicated; conchae; condition; conducting; congenital; congestion; conjunctivitis; connective; consist; consolidation; contact; contagious; contrast; cough; coughing; countries; cranial; cranioventral; cysts; cytokines; damage; days; death; debris; deep; defense; deposition; diagnosis; diameter; dictyocaulus; different; difficult; diffuse; discharge; disease; disorders; distemper; distention; distress; distribution; dogs; domestic; dorsal; dyspnea; early; edema; edematous; effect; efig; emboli; emphysema; endothelial; entire; entry; environmental; enzootic; enzootic pneumonia; eosinophilic; epithelial cells; epithelium; equine; europe; examination; example; excessive; exchange; exercise; experimental; exposure; extensive; extent; exudate; exudation; factors; failure; fatal; features; feline; fever; fibrinous; fibrosis; fig; figs; firm; flora; fluid; foals; focal; foci; foreign; form; formation; free; function; fungal; fungi; general; giant; glands; goats; goblet; granulomas; granulomatous; granulomatous pneumonia; gray; gross; guttural; haemolytica; haemophilus; heart; hematogenous; hemorrhage; hepatic; herpesvirus; high; horses; host; hours; human; human beings; hyaline; hyperemia; hyperplasia; hypersensitivity; idiopathic; immune; important; inclusion; increase; induced; infected; infection; infiltration; inflammation; inflammatory; influenza; inhalation; inhaled; injury; interlobular; interstitial; interstitial pneumonia; intravascular; isolated; large; larvae; laryngeal; larynx; later; leakage; lesions; lesser; leukocytes; life; like; lipid; little; liver; lobes; lobules; long; loss; low; lumen; lungs; lymph; lymphatic; lymphocytes; lymphoid; macrophages; maedi; main; major; malignant; mannheimia; mannheimiosis; masses; material; mechanisms; meconium; mediastinum; membranes; metaplasia; microscopic; mild; milk; mixed; mononuclear; mortality; movement; mucociliary; mucopurulent; mucosa; mucus; multifocal; multocida; muscle; mycobacterium; mycoplasma; mycotic; names; nasal; nasal cavity; nasal mucosa; natural; necropsy; necrosis; necrotic; necrotizing; neoplasms; neutrophils; new; nodes; nodules; normal; notable; numbers; numerous; obstruction; organisms; organs; pale; paranasal; paraquat; parasites; parasitic; parenchyma; particles; passages; pasteurella; pasteurellosis; pathogenesis; pathogens; pattern; pcv2; permeability; persistent; phagocytic; pharynx; pigs; pink; pleural; pleuritis; pleuropneumonia; pneumonia; pneumonitis; pneumonocytes; poor; porcine; portions; possible; postmortem; pouch; pouches; presence; present; pressure; primary; process; production; progress; progressive; proliferation; proteins; pulmonary; pulmonary alveolar; pulmonary cells; pulmonary disease; pulmonary edema; pulmonary fibrosis; pulmonary infection; pulmonary injury; pulmonary lesions; radicals; rare; reaction; recurrent; red; reduced; region; release; repair; respiratory; respiratory disease; respiratory infections; respiratory system; respiratory tract; response; responsible; result; retropharyngeal; rhinitis; rhinotracheitis; rhodococcus; right; role; route; ruminants; secondary; secretions; section; sepsis; septa; septic; septicemia; sequelae; serous; severe; severe cases; severity; sheep; signs; similar; sinuses; sinusitis; size; small; smooth; source; spaces; species; specific; spp; squamous; ssp; stages; stain; streptococcus; studies; suppurative; surface; surfactant; susceptible; swine; syndrome; system; systemic; techniques; term; texture; thick; thoracic; thorax; thrombosis; time; tissue; toxic; toxins; tracheal; tracheobronchial; tract; transient; transmission; trauma; tuberculosis; tumor; type; typical; underlying; upper; vascular; vasculitis; ventilation; vessels; veterinary; viral; virus; viruses; visceral; visible; walls; weight; white; worldwide; years; young
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86. cord-027684-5tpgyjzt
    • author: Protić, Alen
    • title: A 23-year-old man with left lung atelectasis treated with a targeted segmental recruitment maneuver: a case report
    • date: 2020-06-24
    • words: 2498
    • flesch: 44
    • summary: key: cord-027684-5tpgyjzt authors: Protić, Alen; Bura, Matej; Juričić, Kazimir title: A 23-year-old man with left lung atelectasis treated with a targeted segmental recruitment maneuver: a case report date: 2020-06-24 journal: J Med Case Rep DOI: 10.1186/s13256-020-02409-6 sha: doc_id: 27684 cord_uid: 5tpgyjzt BACKGROUND: Lung atelectasis are nonventilated parts of lung tissue and occur as a result of the collapse of the pulmonary parenchyma (alveoli). His procalcitonin level on the day before segmental recruitment maneuver was 0.171 μg/L.
    • keywords: acute; alveoli; artery; atelectasis; bronchus; case; catheter; cmh; day; hemodynamic; hours; icu; left; left lung; lobe; lower; lung; major; maneuver; method; minutes; neck; oxygen; parenchyma; patient; pressure; procedure; protective; pulmonary; recruitment; report; respiratory; segmental; surgery; thorax; upper; ventilation
    • versions: original; plain text
87. cord-030130-n1x6gcn2
    • author: Hurtado, Daniel E.
    • title: Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation
    • date: 2020-08-06
    • words: 5388
    • flesch: 41
    • summary: key: cord-030130-n1x6gcn2 authors: Hurtado, Daniel E.; Erranz, Benjamín; Lillo, Felipe; Sarabia-Vallejos, Mauricio; Iturrieta, Pablo; Morales, Felipe; Blaha, Katherine; Medina, Tania; Diaz, Franco; Cruces, Pablo title: Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation date: 2020-08-06 journal: Changes in lung regional strain during spontaneous breathing were concurrent with the tomographic progression of the nonaerated-tissue compartment of the lung and a reduction of the normal-tissue compartment, in accordance with de-recruitment phenomenon, with collapse progression being higher in ventral regions of the lung.
    • keywords: acute; aerated; aeration; alveolar; analysis; areas; biomechanical; breathing; changes; clinical; compartment; damage; deformation; differences; distribution; dorsal; edema; eelv; end; experimental; failure; fig; figure; file; global; group; heterogeneity; high; images; increase; inflammation; injured; injury; low; lung; lung injury; maps; mask; mean; mechanical; micro; min; non; pressure; progression; regional; regional strain; regions; respiratory; roi; rois; shi; significant; spontaneous; strain; stress; study; subjects; support; time; tissue; ventilation; ventral; volumetric
    • versions: original; plain text
88. cord-031033-v4yetn4f
    • author: Martin-Loeches, Ignacio
    • title: The importance of airway and lung microbiome in the critically ill
    • date: 2020-08-31
    • words: 5112
    • flesch: 20
    • summary: This link needs to be further explored before we can conclude that lung microbiome dysbiosis is a potential target for treatment (Fig. 1) . To date, more than 30 studies have used sensitive, culture-independent techniques to study lung bacteria in healthy volunteers, and none has failed to detect a distinct bacterial signal [21] .
    • keywords: 16s; acute; administration; airways; alveolar; analysis; antibiotic; ards; area; bacteria; care; changes; clinical; communities; composition; critical; critical illness; different; digestive; disease; diversity; dna; dysbiosis; effects; enrichment; environment; evidence; factors; gut; healthy; host; human; icu; illness; impact; important; individual; infection; inflammatory; influence; injury; intensive; interventions; lavage; lower; lung; lung microbiome; mechanical; microbial; microbiome; molecular; normal; nosocomial; nutrient; outcomes; pathogens; patients; pneumonia; probiotics; pulmonary; randomized; respiratory; respiratory tract; response; review; risk; role; sdd; selective; sepsis; sequencing; species; specific; studies; study; system; target; tract; understanding; ventilator; years
    • versions: original; plain text
89. cord-034406-i1hbx3pz
    • author: Matthews, Abigail A.
    • title: Developing inhaled protein therapeutics for lung diseases
    • date: 2020-10-30
    • words: 8744
    • flesch: 37
    • summary: As only one medicine Respimat uses SMI, its suitability for protein drug delivery is not clear. It is probable that HYDRA nebulisers may be developed for pulmonary protein drug delivery.
    • keywords: absorption; acids; activity; addition; administration; aerosol; aggregates; aggregation; airway; alveolar; amino; anti; antibodies; antibody; approach; aqueous; asthma; bioavailability; biological; carrier; challenges; changes; chemical; clearance; concentrations; copd; cystic; deamidation; degradation; delivery; denaturation; deposition; development; device; different; diseases; dose; drug; drug delivery; dry; drying; effective; effects; efficacy; example; excipients; fibrosis; formulation; fragments; high; higher; important; inhalation; inhaled; instance; insulin; issues; jet; kda; large; layer; liquid; local; lower; lung; macrophages; mechanisms; mesh; molecules; mucus; nanoparticles; nebulisation; nebulisers; need; non; novel; order; oxidation; particles; patients; pattern; peg; pegs; pegylated; pegylation; peptide; physical; powder; protein; protein therapeutics; pulmonary; raffinose; respiratory; retention; review; size; small; specific; stability; studies; study; surface; surfactant; systemic; target; therapeutics; therapy; time; toxicity; treatment; trehalose; ultrasonic; uptake; use; zone
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90. cord-034469-ew90eef4
    • author: Dos Santos Rocha, Andre
    • title: Physiologically variable ventilation reduces regional lung inflammation in a pediatric model of acute respiratory distress syndrome
    • date: 2020-10-31
    • words: 4858
    • flesch: 35
    • summary: Subsequently, animals were randomized for the absence (CTRL) or presence (ARDS) of lung injury. Changes in respiratory mechanical parameters relative to those obtained immediately after the induction of lung injury are displayed in Fig. 2 .
    • keywords: activity; acute; additional; aerated; aeration; analyses; animals; ards; blood; breathing; changes; control; conventional; ctrl; data; differences; distress; distribution; effect; elastance; experimental; fdg; file; fio; fraction; functional; gas; groups; healthy; higher; imaging; inflammation; injury; lower; lung; mechanical; model; non; observed; parameters; pcv; pediatric; perfusion; pet; physiological; positive; presence; pressure; pulmonary; pvv; rabbits; regional; respiratory; results; spect; study; syndrome; tidal; tissue; uptake; variable; ventilation; volume; zones
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91. cord-102958-q8jamg07
    • author: Hahka, Taija M.
    • title: Resiniferatoxin (RTX) ameliorates acute respiratory distress syndrome (ARDS) in a rodent model of lung injury
    • date: 2020-09-14
    • words: 3752
    • flesch: 38
    • summary: Combined with the results shown in the current model of ALI, the potential of RTX to rescue lung function and protect multiple organs from collateral damage due to lung injury triggered inflammation is very encouraging and warrants additional studies as a rescue therapy for patients with lung injuries or infections resulting in inflammatory -mediated pneumonia. Therefore, in the current study we hypothesized that ablation of lung afferent innervation (thoracic spinal) by application of an ultrapotent, selective afferent neurotoxin, resiniferatoxin (RTX) will modify the course of the pathology including lung edema and local pulmonary inflammation associated with progressive ALI. Committee of the University of Nebraska Medical Center and performed in accordance with the National Institutes of Health's Guide for Use and Care of Laboratory Animals and with ARRIVE guidelines.
    • keywords: activation; acute; administration; afferent; ali; ards; bleomycin; blood; blue; cardiac; cardiopulmonary; cytokine; data; day; delivery; distress; edema; epidural; evans; extravasation; failure; fibers; fibrosis; figure; function; ganglia; gas; heart; inflammation; inflammatory; injection; injury; intra; lung; model; nerve; neurons; pain; pathology; plasma; post; potential; pulmonary; rats; receptor; reduced; reflex; resiniferatoxin; respiratory; role; rtx; saline; sensory; small; spinal; stellate; study; substance; sympathetic; thoracic; transient; trpv1; weight
    • versions: original; plain text
92. cord-252810-rko3e5va
    • author: Basil, Maria C.
    • title: The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future
    • date: 2020-04-02
    • words: 14844
    • flesch: 26
    • summary: An alternate approach to lung bioengineering has been developed that is based on removing damaged epithelial cells from distal lungs while maintaining the integrity of the basement membrane, surrounding lung cells and matrix, and the functionality of lung vasculature. The key signaling factors and the main stages of the in vitro derivation of lung epithelial cells are provided.
    • keywords: activation; acute; additional; adult; airway; airway cells; alveolar; alveolar cells; alveolar epithelial; alveoli; alveolus; analysis; area; associated; at1; at2; at2 cells; atlas; barkauskas et; basal; basal cells; bascs; bioengineering; bmp; capacity; capillary; cell types; cells; cellular; cftr; chronic; ciliated; circulation; clinical; club; complex; copd; critical; cross; culture; cystic; data; development; differentiation; direct; disease; distal; distal airway; distal lung; distinct; diversity; donor; early; embryonic; endoderm; endothelial; epithelial; epithelial cells; et al; evidence; evlp; example; exchange; expansion; expression; extracorporeal; fate; fibroblasts; fibrosis; fibrotic; figure; function; future; gas; genetic; green et; growth; guo; heterogeneity; high; homeostasis; huang et; human; human lung; immune; induced; inference; influenza; injured; injury; ipscs; krt5; like; lineage; lung; lung cells; lung development; lung epithelial; lung injury; lung regeneration; macrophages; maintenance; major; markers; matrix; mature; mccauley et; mesenchymal; methods; mice; miller et; model; modeling; morrisey; mouse; multiple; murine; need; neuroendocrine; new; niche; normal; notch; number; organoids; pathways; patients; pdgfra; perfusion; petersen et; pluripotent; pluripotent stem; pneumonectomy; points; population; potential; presence; primary; production; progenitor cells; progenitors; proliferation; promote; protein; proximal; pulmonary; rare; recent; recovery; regeneration; regions; renewal; repair; resident; respiratory; response; rise; role; scgb1a1; scrna; secretory; self; seq; sftpc; signaling; significant; single; small; source; specific; specification; states; stem; stem cells; studies; study; support; surface; system; targeted; techniques; term; therapeutic; time; tissue; trachea; trajectories; trajectory; transcriptomic; transplantation; types; vascular; vivo; wnt; zepp et
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93. cord-253891-d1ei287l
    • author: Geddes, Duncan
    • title: The history of respiratory disease management
    • date: 2016-04-23
    • words: 2192
    • flesch: 59
    • summary: Management of lung disease has vastly improved but the impact of disease remains. Lung diseases surge and sometimes seem to go.
    • keywords: 1970s; advances; agonists; air; antibiotics; asthma; better; cancer; care; century; chest; chronic; death; delivery; devices; diagnosis; disease; doctor; drugs; imaging; important; infections; key; london; lung; major; management; medicine; new; obstructive; patients; pneumonia; positive; pulmonary; respiratory; rich; scientific; support; surgery; today; treatment; use; years
    • versions: original; plain text
94. cord-257114-pxmflm2c
    • author: BURGUETE, SERGIO R.
    • title: Lung transplant infection
    • date: 2012-12-26
    • words: 11402
    • flesch: 31
    • summary: Invasive lung infection with Candida is very infrequent even in the LT recipient colonized with Candida. The incidence of CMV infection has been reported to range from 30% to 86% in post-LTR, with a mortality of 2-12%.
    • keywords: activation; acute; agents; airway; allograft; amphotericin; antifungal; aspergillosis; aspergillus; associated; bacterial; basiliximab; bos; bronchial; bronchiolitis; burkholderia; candida; care; cases; cause; cell; centres; chronic; clinical; cmv; colonization; colonized; combination; common; community; complications; culture; cystic; cytomegalovirus; data; days; development; diagnosis; disease; donor; early; effects; factors; fibrosis; fungal; general; gram; group; guidelines; heart; high; human; immunosuppression; impact; important; incidence; increase; induction; infection; influenza; inhaled; international; invasive; late; life; lower; ltr; lung; lung transplantation; lymphocytes; majority; management; months; morbidity; mortality; mycophenolate; negative; obliterans; organ; organ transplant; organisms; outcomes; pathogens; patients; period; pneumonia; positive; post; present; pretransplant; prevention; prophylaxis; pulmonary; recent; recipients; reduction; regimen; rejection; resistance; respiratory; results; review; ribavirin; risk; role; rsv; screening; severe; significant; society; solid; solid organ; species; studies; study; survival; syndrome; therapy; transplant; transplant patients; transplant recipients; transplantation; treatment; use; valganciclovir; viral; virus; voriconazole; year
    • versions: original; plain text
95. cord-258362-6qk2brax
    • author: Chang, A.B.
    • title: Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis()
    • date: 2010-12-04
    • words: 5464
    • flesch: 36
    • summary: Non-CF bronchiectasisclinical and HRCT evaluation Bronchiectasis in childhood: I. Clinical Survey of 160 Cases Mortality in bronchiectasis: a longterm study assessing the factors influencing survival Exacerbations in non cystic fibrosis bronchiectasis: Clinical features and investigations Early life origins of chronic obstructive pulmonary disease Cough in the pediatric population COPD: a pediatric disease Bronchiectasis secondary to primary immunodeficiency in children: longitudinal changes in structure and function State of the Art -Chronic wet cough: protracted bronchitis, chronic suppurative lung disease and bronchiectasis Outcomes in Children Treated for Persistent Bacterial Bronchitis Qualitative Analysis of High Resolution Computed Tomography Scans in Severe Asthma Evaluation and outcome of young children with chronic cough Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood An Investigation into Causative Factors in Patients with Bronchiectasis Prevalence and economic burden of bronchiectasis Trends and Burden of Bronchiectasis-Associated Hospitalizations: USA New Zealand national incidence of bronchiectasis 'too high' for a developed country The biology of bacterial colonization and invasion of the respiratory mucosa Criteria for development of animal models of diseases of the respiratory system: the comparative approach in respiratory disease model development Studies of pneumonia in childhood: IV. key: cord-258362-6qk2brax authors: Chang, A.B.; Byrnes, C.A.; Everard, M.L. title: Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis() date: 2010-12-04 journal: Paediatr Respir Rev DOI: 10.1016/j.prrv.2010.10.008 sha: doc_id: 258362 cord_uid: 6qk2brax Current diagnostic labelling of childhood bronchiectasis by radiology has substantial limitations.
    • keywords: adults; airways; appropriate; associated; asthma; australian; bacterial; bronchial; bronchiectasis; bronchitis; chest; childhood; children; chronic; clinical; common; copd; cough; criteria; csld; current; cystic; damage; data; decline; development; diagnosis; dilatation; disease; early; evidence; exacerbations; factors; fev; fibrosis; following; function; growth; high; hrct; infections; inflammation; intensive; life; likely; longitudinal; lower; lung; management; non; patients; persistent; productive; progression; pulmonary; radiological; ratio; resolution; respiratory; risk; scans; severe; significant; signs; spectrum; studies; study; suppurative; symptoms; treatment; wet; years; yrs
    • versions: original; plain text
96. cord-260132-lqpk3ig7
    • author: Quartuccio, Luca
    • title: Urgent avenues in the treatment of COVID-19: Targeting downstream inflammation to prevent catastrophic syndrome
    • date: 2020-04-19
    • words: 2468
    • flesch: 33
    • summary: In general, the cytokine profile of SARS patients showed a marked elevation of the Th1 cytokine interferon (IFN)-gamma, of inflammatory cytokines interleukin (IL)-1, IL-6 and IL-12 for at least 2 weeks after disease onset. Importantly, they proved effective in autoinflammatory diseases, and also in macrophage activation syndrome, which rarely complicates the course of autoinflammatory diseases; there is then a strong rationale for their use in SARS patients.
    • keywords: activation; acute; antibody; baricitinib; cell; clinical; complement; coronavirus; cov; covid-19; cytokine; damage; disease; downstream; early; fibrosis; higher; il-1; il-6; immune; immunological; infection; inflammation; inflammatory; injury; interferon; kinase; late; levels; lung; outbreak; patients; receptor; release; respiratory; response; sars; severe; signalling; syndrome; systemic; targeting; time; tocilizumab; treatment; useful; viral; virus
    • versions: original; plain text
97. cord-260729-b12v3c8c
    • author: de Lang, Anna
    • title: Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques
    • date: 2007-08-10
    • words: 6813
    • flesch: 46
    • summary: A prospective study The severe acute respiratory syndrome Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome An interferongamma-related cytokine storm in SARS patients Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome Analysis of serum cytokines in patients with severe acute respiratory syndrome Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome A probable role for IFN-gamma in the development of a lung immunopathology in SARS Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: Possible relevance to pathogenesis Chemokine upregulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection Inhibition of cytokine gene expression and induction of chemokine genes in non-lymphatic cells infected with SARS coronavirus Modeling the early events of severe acute respiratory syndrome coronavirus infection in vitro Severe acute respiratory syndrome coronavirus fails to activate cytokinemediated innate immune responses in cultured human monocyte-derived dendritic cells Inhibition of beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3 Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists Treatment of SARS with human interferons Potent inhibition of SARS-associated coronavirus (SCOV) infection and replication by type I interferons (IFN-alpha/beta) but not by type II interferon (IFN-gamma) Ribavirin and interferon-beta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Integrated molecular signature of disease: Analysis of influenza virus-infected macaques through functional genomics and proteomics Hybrid hierarchical clustering with applications to microarray data Analyzing microarray data using cluster analysis Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry The acute respiratory distress syndrome Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclincyclin-dependent kinase complex and blocks S phase progression in mammalian cells Lung pathology of severe acute respiratory syndrome (SARS): Approximately 20%-30% of SARS patients require management in intensive care units, and the overall fatality rate has approached 10%.
    • keywords: able; activation; acute; acute respiratory; analysis; animals; antiviral; cells; change; chemokines; clinical; coronavirus; cov; cov infection; cxcl10; cynomolgus; cytokines; data; day; dendritic; early; experiments; expression; figure; fold; functional; genes; host; human; ifn; ifns; il-8; immune; immunohistochemistry; induced; induction; infected; infection; inhibition; innate; interferon; levels; low; lung; macaques; microarray; mock; mouse; mrna; order; pathways; patients; pcr; pdcs; phase; phosphorylated; pieces; presence; production; protein; regulated; replication; respiratory; response; samples; sars; severe; signaling; stat1; strong; studies; study; syndrome; transcription; translocation; treatment; type; viral; virus; vitro
    • versions: original; plain text
98. cord-261640-ehc123p7
    • author: Smith, Maxwell L.
    • title: Vaping-related lung injury
    • date: 2020-10-27
    • words: 3701
    • flesch: 36
    • summary: Electronic cigarettes: the new face of nicotine delivery and addiction The evolving landscape of electronic cigarettes: a systematic review of recent evidence Vaping versus JUULing: how the extraordinary growth and marketing of JUUL transformed the US retail ecigarette market Tobacco use among middle and high school students -United States Flavored E-cigarette use and progression of vaping in adolescents Electronic cigarette use and progression from experimentation to established smoking Characteristics of hospitalized and nonhospitalized patients in a nationwide outbreak of E-cigarette, or vaping, product use-associated lung injury -United States Vitamin E acetate in bronchoalveolar-lavage fluid associated with EVALI Vape cart additive makers pull products as others go dark Potential for release of pulmonary toxic ketene from vaping pyrolysis of vitamin E acetate An animal model of inhaled vitamin E acetate and EVALI-like lung injury What are the mechanisms underlying vaping-induced lung injury? NIH workshop report: Ecigarette or vaping product use associated lung injury (EVALI): developing a research agenda Radiologic, pathologic, clinical, and physiologic findings of electronic cigarette or vaping product useassociated lung injury (EVALI): evolving knowledge and remaining questions Imaging of vapingassociated lung disease Imaging findings of vaping-associated lung injury Pulmonary illness related to E-cigarette use in Illinois and Wisconsin -final report Respiratory failure caused by lipoid pneumonia from vaping e-cigarettes 2020) Rare descriptions of additional patterns of lung injury have been described, including giant cell interstitial pneumonia that is a form of pneumoconiosis related to hard metal exposure In one case report, the presence of giant cell interstitial pneumonia on lung biopsy was hypothesized to be from the combustion and aerosolization of metal elements of the vaping apparatus, which was supported by investigation with inductively coupled plasma mass spectrometry [29] .
    • keywords: abnormalities; acute; alveolar; associated; biopsy; cases; cigarette; clinical; devices; diffuse; disease; electronic; evali; exogenous; exposure; features; fig; findings; giant; histologic; hypersensitivity; illness; imaging; injury; interstitial; laden; likely; lipoid; long; lung; lung injury; macrophages; new; nicotine; oil; organizing; pathologic; patients; patterns; pneumonia; present; product; pulmonary; red; report; respiratory; similar; smoking; specimens; studies; subacute; term; tobacco; use; vacuoles; vaping; vea
    • versions: original; plain text
99. cord-264308-y6xuxj16
    • author: Liu, Rui
    • title: Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses
    • date: 2015-05-26
    • words: 7696
    • flesch: 50
    • summary: The evaluation of a panel of antiviral and anti-inflammatory agents in mouse lung slice model. To validate this precision cut mouse lung slice model in screening and evaluation of both antiviral and anti-inflammatory drugs against influenza virus infection in one assay using NA and IP-10 as readouts, four categories of known antiviral and anti-inflammatory drugs were tested for their antiviral and anti-inflammatory activities.
    • keywords: activities; activity; agents; animal; anti; antiviral; assay; cell; chemokines; correlation; cost; culture; cytokines; data; days; dead; drugs; effects; efficacy; et al; evaluation; ex vivo; expression; factor; fig; h1n1; human; ifn; il-1b; immune; infected; infection; inflammation; inflammatory; influenza; influenza infection; influenza virus; ip-10; lethal; levels; live; lung; lung slices; medium; mice; mip-3a; model; mouse; mouse lung; pbs; post; pr8; preparation; protein; rantes; receptor; replication; response; results; ribavirin; screening; similar; slice model; slices; studies; study; thick; time; treatment; virus; virus infection; viruses; vivo
    • versions: original; plain text
100. cord-265606-c1zo47sw
     • author: Feng, Zhe-Min
     • title: Lung Cancer with Diffuse Ground-glass Shadow in Two Lungs and Respiratory Failure
     • date: 2016-08-05
     • words: 2310
     • flesch: 43
     • summary: The bronchioloalveolar carcinoma and peripheral adenocarcinoma spectrum of diseases Bronchioloalveolar carcinoma: An exceptional cause of diffuse lung disease in a patient with acute myeloid leukemia Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma Aspects of bronchioloalveolar carcinoma and of adenocarcinoma with a bronchioloalveolar component: CT findings A case of diffuse pneumonic type of mucinous adenocarcinoma treated with reduction surgery Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung [5] The pathological diagnosis of diffuse lung adenocarcinoma patients was more advanced, no surgical opportunity.
     • keywords: acute; adenocarcinoma; admission; antibody; blood; cancer; cells; chest; clinical; diabetes; diagnosis; diffuse; diseases; examination; exudation; failure; fever; fungal; glass; ground; heart; imaging; infection; interstitial; like; lung; negative; nodules; oxygen; patient; pneumonia; pulmonary; range; ray; respiratory; scan; shadow; sputum; tblb; test; treatment; tuberculosis; type; uniform; viral; virus
     • versions: original; plain text
101. cord-265658-wjqezs0v
     • author: Carranza-Rosales, Pilar
     • title: Modeling tuberculosis pathogenesis through ex vivo lung tissue infection
     • date: 2017-09-12
     • words: 3244
     • flesch: 39
     • summary: Also, infected lung slice cells expressed markers of type II pneumocytes and phosphorylated Akt and ERK1/2, resembling the phenotype of natural and experimentally-derived OPA in sheep [7] . Precision cut lung tissue slices (PCLTS) is an experimental model, in which all the usual cell types of the organ are found, the tissue architecture and the interactions amongst the different cells are maintained.
     • keywords: alveolar; analysis; assay; bacilli; bacterial; bcg; bovis; cells; cfu; conditions; cut; different; disease; epithelial; experimental; expression; fig; h37rv; human; immune; induction; infected; infection; influenza; interactions; lung; macrophages; model; murine; mycobacterium; pclts; pcr; pneumocytes; precision; respiratory; response; slices; strains; studies; study; system; time; tissue; tnf; tuberculosis; types; usa; virus; viruses; vivo
     • versions: original; plain text
102. cord-266067-wrouqdcj
     • author: Haywood, Nathan
     • title: Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome
     • date: 2020-09-17
     • words: 6944
     • flesch: 42
     • summary: This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS. Here, early animal studies have demonstrated the ability of in vivo lung perfusion (IVLP) to rehabilitate sepsis-induced ARDS
     • keywords: acute; agonist; ards; artery; assessment; associated; circuit; clinical; colleagues; compliance; control; current; delivery; distress; donor; early; ecmo; edema; evidence; evlp; ex vivo; expression; extracorporeal; figure; function; gas; group; high; human; impact; improved; inflammation; inflammatory; injury; investigations; isolated; ivlp; large; left; lps; lung; lung injury; lung perfusion; management; membrane; model; mortality; optimal; outcomes; oxygenation; patients; perfusate; perfusion; period; phase; physiologic; platform; porcine; prolonged; pulmonary; recent; receptor; rehabilitation; respiratory; results; sepsis; severe; significant; similar; solution; steen; studies; study; swine; syndrome; systemic; time; transplantation; treatment; trial; use; vivo; vivo lung
     • versions: original; plain text
103. cord-267979-k70gnrdw
     • author: Yıldız-Peköz, Ayca
     • title: Advances in Pulmonary Drug Delivery
     • date: 2020-09-23
     • words: 3263
     • flesch: 34
     • summary: The development of modern-day inhalers, e.g., pressurised metered-dose inhalers (pMDIs) and more recently, dry powder inhalers (DPIs), jet and vibrating mesh nebulisers (VMNs), and soft mist inhalers (SMIs), has given pulmonary drug delivery a momentum boost that transformed a therapeutic niche into a market predicted to hit US$41.5 billion by 2026 In this Special Issue, a cross-section of current research in the field of pulmonary drug delivery is published.
     • keywords: administration; aerosol; amps; anti; antibiotics; approach; areas; bedaquiline; cannula; carrier; colleagues; delivery; deposition; development; disease; dose; drug; dry; effects; flow; fluticasone; formulation; hfnc; high; higher; infections; inhalable; inhalation; inhaled; inhalers; isoniazid; issue; leucine; liposomes; lung; model; mycobacterial; nasal; non; particle; patient; powder; pulmonary; rate; research; respiratory; silico; special; spray; stability; studies; study; suitable; therapy; treatment; use; vitro
     • versions: original; plain text
104. cord-268729-n7slf5tx
     • author: Wissinger, E L
     • title: Manipulation of acute inflammatory lung disease
     • date: 2008-05-07
     • words: 10114
     • flesch: 26
     • summary: A critical pathway for clearance of pathogens and infected lung epithelial cells is via NO and reactive oxygen and nitrogen species. A virus-induced infl ammatory cytokine production in airway epithelial cells IkappaB kinase is a critical regulator of chemokine expression and lung infl ammation in respiratory syncytial virus infection Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa Airway epithelium controls lung infl ammation and injury through the NF-kappa B pathway Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury Peroxisome proliferator-activated receptor-gamma is a new therapeutic target in sepsis and infl ammation Involvement of PPAR nuclear receptors in tissue injury and wound repair Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced REVIEW expression of intercellular adhesion molecule-1 in human lung epithelial cells The many paths to p38 mitogen-activated protein kinase activation in the immune system MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption Critical involvement of p38 MAP kinase in pertussis toxin-induced cytoskeletal reorganization and lung permeability Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice Chemoattractant receptor signaling and the control of lymphocyte migration Airway infl ammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases Tissue-and stimulus-dependent role of phosphatidylinositol 3-kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury Blockade of infl ammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Rhinovirus regulation of IL-1 receptor antagonist in vivo and in vitro : a potential mechanism of symptom resolution Interleukin-1 receptor antagonist transiently impairs antibacterial defense but not survival in murine pneumococcal pneumonia Interleukin 12 administration enhances Th1 activity but delays recovery from infl uenza
     • keywords: 1bb; absence; activation; activity; acute; administration; aeruginosa; airway; alveolar; antigen; apoptosis; associated; bacterial; beneficial; blockade; cd4; cd8; cells; chemokine; clearance; critical; cytokine; damage; defense; dendritic; dependent; disease; effector; effects; endothelial; epithelial; example; expression; factor; function; gamma; homeostasis; host; human; ibalt; ifn; il-10; immune; immunity; immunopathology; induced; induction; infected; infection; infl; inflammation; inflammatory; influenza; inhaled; inhibition; innate; integrin; interferon; kinase; late; ligand; like; likely; local; lung; lung infection; lymphocyte; lymphoid; macrophages; manipulation; memory; mice; migration; model; modulation; molecules; mouse; murine; nalt; nasal; neoformans; neutralization; neutrophil; nitric; nodes; non; organized; ox40; oxide; oxygen; parenchyma; pathogens; pathology; pathway; pneumoniae; production; protein; pulmonary; rantes; reactive; receptor; recruitment; reduced; regulation; replication; resolution; respiratory; responses; review; role; rsv; signaling; sites; species; specific; stimulatory; strategies; strategy; survival; syncytial; t cells; targeted; therapeutic; tissue; tnf; toll; tract; treatment; type; uenza; viral; virus; virus infection; vivo
     • versions: original; plain text
105. cord-274474-u2fdicgz
     • author: Majumder, Joydeb
     • title: Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus
     • date: 2020-10-13
     • words: 10114
     • flesch: 42
     • summary: [89] Here, we have summarized recent reports of several lipid-based nanosystems including liposome, nanostructured lipid carriers (NLCs), and micelles and their application as targeted drug delivery systems. [1, 2] Therefore, methods of developing new therapeutic solutions as well as improving the current therapies for the common lung diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease, lung cancer, and coronavirus infections remain the main focus in the fields of targeted drug delivery.
     • keywords: a549; accumulation; acids; active; activity; anticancer; antisense; antiviral; applications; aso; aunps; authors; bind-014; cancer; cancer cells; carbon; carriers; cells; cellular; chitosan; clinical; cnts; combination; complex; contrast; conventional; core; coronavirus; cov-2; covid-19; cystic; decades; delivery; detection; development; different; diseases; dna; doxorubicin; drug; drug delivery; effective; effects; efficacy; egfr; et al; etc; fibrosis; figure; formulation; free; gene; gold; growth; higher; human; hydrophobic; imaging; infection; inhalation; janus; lipid; liposomal; liposomes; loaded; lung; lung cancer; mers; mesoporous; methods; mice; micelles; model; nanocarrier; nanomaterials; nanoparticles; nanoscale; nanosized; nanotherapeutics; new; nlc; nlcs; non; nsclc; nucleic; oligonucleotides; order; paclitaxel; passive; patient; peg; plga; polymeric; prepared; promising; proteins; recent; receptor; reduced; release; researchers; resistance; respiratory; results; review; sars; severe; significant; silica; sirna; site; small; specific; study; surface; syndrome; system; targeted; targeting; therapeutics; therapy; treatment; tumor; types; uptake; vaccine; viral; vivo; years
     • versions: original; plain text
106. cord-276732-u2d1z4ip
     • author: Mauri, Tommaso
     • title: Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice
     • date: 2017-03-06
     • words: 4450
     • flesch: 42
     • summary: The acute respiratory distress syndrome Soluble receptor for advanced glycation end-products predicts impaired alveolar fluid clearance in acute respiratory distress syndrome Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials Treating ARDS: new hope for a tough problem Angiotensin-(1-7) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental acute respiratory distress syndrome Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice Stem cell therapy for acute respiratory distress syndrome: a promising future Allogenic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebocontrolled pilot study Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization Mechanical ventilationassociated lung fibrosis in acute respiratory distress syndrome: a significant contributor to poor outcome Alveolar pentraxin 3 as an early marker of microbiologically confirmed pneumonia: a threshold-finding prospective observational study The yin-yang of long pentraxin PTX3 in inflammation and immunity Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation Proteomic analysis of tumor necrosis factor-alphainduced secretome of human adipose tissue-derived mesenchymal stem cells Mesenchymal stromal cell-derived PTX3 promotes wound healing via fibrin remodeling Mesenchymal stem cells: mechanisms of potential therapeutic benefit in ARDS and sepsis An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice Inhibition of pulmonary fibrosis by the chemokine IP-10/CXCL10 Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs Aspiration-induced lung injury Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice Unilateral acid aspiration augments the effects of ventilator lung injury in the contralateral lung Spontaneous effort during mechanical ventilation: maximal injury with less positive endexpiratory pressure Elevated plasma and alveolar levels of soluble receptor for advanced glycation endproducts are associated with severity of lung dysfunction in ARDS patients Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice Long pentraxin PTX3 deficiency worsens LPS-induced acute lung injury Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6 Regulation of leukocyte recruitment by the long pentraxin PTX3 Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation Implementation of a pan-genomic approach to investigate holobiont-infecting microbe interaction: a case report of a leukemic patient with invasive mucormycosis We are thankful to all the personnel working in the University of Milan-Bicocca, San Gerardo Hospital and Humanitas Institute for the continuous support and collaboration. Histology found reduction of lung injury, albeit non-significant (Table 1 ).
     • keywords: acid; acute; acute lung; additional; administration; alveolar; analysis; ards; aspiration; cells; collapse; comparison; data; distress; dry; early; edema; effects; evolution; experimental; fibrosis; fibrotic; fig; figure; file; human; i.p; improved; inflammation; inflammatory; injury; lack; levels; long; lung; lung injury; mesenchymal; mice; model; mscs; non; oxygenation; pbs; previous; ptx3; recovery; reduced; reduction; respiratory; short; significant; stem; studies; study; syndrome; table; term; tissue; treatment; weeks; wet; −/−
     • versions: original; plain text
107. cord-276927-rxudwp2v
     • author: Barbas, Carmen Sílvia Valente
     • title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome
     • date: 2012-08-23
     • words: 8003
     • flesch: 26
     • summary: Revaluation of ARDS patients on the third day of evolution (Sequential Organ Failure Assessment (SOFA), biomarkers and response to infection therapy) allows changes in the initial treatment plans and can help decrease ARDS mortality. Fibrosis can be evident histologically as early as one week after the onset of ARDS and procollagen III peptide, a precursor of collagen synthesis, can be elevated in bronchoalveolar lavage fluid of ARDS patients at the time of tracheal intubation, its increment being associated with a poor ARDS prognosis.
     • keywords: acute; acute lung; acute respiratory; airway; alveolar; analysis; ards; ards patients; arterial; artery; assessment; assist; authors; better; blood; body; care; clinical; cmh; collapse; colleagues; control; day; days; decrease; definition; diagnosis; disease; distress; distress syndrome; early; ecmo; edema; effects; elevated; extracorporeal; factors; failure; fluid; group; high; higher; hospital; iii; improvement; increase; infection; injury; intubation; levels; lower; lung; lung injury; management; maneuvers; mechanical; membrane; mmhg; mortality; mrs; new; noninvasive; order; organ; outcome; oxygenation; pao; patients; peep; phase; pneumonia; positive; practice; pressure; prone; protective; pulmonary; randomized; recent; recruitment; respiratory; respiratory distress; review; right; risk; score; sepsis; septic; severe; shock; significant; sofa; strategy; study; support; syndrome; therapy; tidal; titration; tomography; tpg; treatment; trial; use; vascular; ventilation; ventilatory; volume; weight
     • versions: original; plain text
108. cord-277455-r69j2tnw
     • author: Lim, Jun Hyeok
     • title: Small-cell Lung Cancer Presenting as Fatal Pulmonary Hemorrhage
     • date: 2018-03-21
     • words: 1366
     • flesch: 42
     • summary: NCCN Clinical Practice Guidelines in Oncology Small Cell Lung Cancer-Version 2 Small-cell lung cancer Thrombocytopenia in solid tumors Bone marrow involvement in small cell lung cancer: prognostic significance and correlation with hematological and biochemical parameters Delays in the diagnosis and treatment of lung cancer Lactic acidosis with small cell carcinoma. Bone marrow examination is a diagnostic process for evaluating hematological abnormality or staging the disease.
     • keywords: anti; antibody; blood; bone; cancer; case; cell; chemotherapy; clinical; count; day; diagnosis; examination; fatal; hemorrhage; lung; marrow; negative; normal; patient; platelet; presentation; range; rapid; respiratory; sclc; severe; small; thrombocytopenia; treatment
     • versions: original; plain text
109. cord-278846-nqj7ctk3
     • author: Ogger, Patricia P.
     • title: Macrophage metabolic reprogramming during chronic lung disease
     • date: 2020-11-12
     • words: 10150
     • flesch: 16
     • summary: The iron-y of iron overload and iron deficiency in chronic obstructive pulmonary disease Increased iron sequestration in alveolar macrophages in chronic obtructive pulmonary disease Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages Mitochondrial dysfunction in macrophages: A key to defective bacterial phagocytosis in COPD Alveolar macrophage immunometabolism and lung function impairment in smoking and chronic obstructive pulmonary disease Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model Mitochondrial iron chelation ameliorates cigarette smokeinduced bronchitis and emphysema in mice Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine Progress in understanding mucus abnormalities in cystic fibrosis airways Lung inflammation in cystic fibrosis: pathogenesis and novel therapies Inflammation in cystic fibrosis: an update Inflammation and its genesis in cystic fibrosis Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis Inflammation, infection, and pulmonary function in infants and young children with cystic fibrosis Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/-mice CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis Characterization of macrophage activation states in patients with cystic fibrosis Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors Tgf-β1 inhibits Cftr biogenesis and prevents functional rescue of ΔF508-Cftr in primary differentiated human bronchial epithelial cells Series 'matrix metalloproteinases in lung health and disease': the role of matrix metalloproteinases in cystic fibrosis lung disease Glutathione and infection Systemic deficiency of glutathione in cystic fibrosis Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients Transforming growth factorβ activation in the lung: Focus on fibrosis and reactive oxygen species Impaired defenses of neonatal mouse alveolar macrophage with cftr deletion are modulated by glutathione and TGFβ1 Human cystic fibrosis macrophages have defective calciumdependent protein kinase C activation of the NADPH oxidase, an effect augmented by burkholderia cenocepacia Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection Pseudomonas aeruginosa utilizes host-derived itaconate to redirect its metabolism to promote biofilm formation Pulmonary pathogens adapt to immune signaling metabolites in the airway Lipid metabolism in cystic fibrosis Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis Metabolic reprograming of cystic fibrosis macrophages via the IRE1α arm of the unfolded protein response results in exacerbated inflammation Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis Oral DHA supplementation in ΔF508 homozygous cystic fibrosis patients Bioavailability and safety of a high dose of docosahexaenoic acid triacylglycerol of algal origin in cystic fibrosis patients: a randomized, controlled study Effect of an 8-month treatment with ω-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis Idiopathic pulmonary fibrosis: Guidelines for diagnosis and clinical management have advanced from consensus-based in 2000 to evidence-based in 2011 Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis: An integral model Macrophages: Friend or foe in idiopathic pulmonary fibrosis? Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis Metalloproteinases in idiopathic pulmonary fibrosis Accumulation of damaged mitochondria in alveolar macrophages with reduced OXPHOS related gene expression in IPF Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis Glucose transporter-1 distribution in fibrotic lung disease: Association with [18F]-2-fluoro-2-deoxyglucose-PET scan uptake, inflammation, and neovascularization Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells Succinate: a metabolic signal in inflammation Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation Itaconate controls the severity of pulmonary fibrosis Reactive oxygen species as signaling molecules in the development of lung fibrosis Macrophages and iron metabolism The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size Delta-like 4 induces Notch signaling in macrophages: implications for inflammation Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis Iron laden macrophages in idiopathic pulmonary fibrosis: the telltale of occult alveolar hemorrhage? Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation The transferrin receptor CD71 delineates functionally distinct airway macrophage subsets during idiopathic pulmonary fibrosis TOLLIP, MUC5B, and the response to N-acetylcysteine among individuals with idiopathic pulmonary fibrosis Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial Metformin: an old dog with a new trick? Metformin attenuates lung fibrosis development via NOX4 suppression Metformin reverses established lung fibrosis in a bleomycin model Metformin does not affect clinically relevant outcomes in patients with idiopathic pulmonary fibrosis Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages SARS-CoV-2 and viral sepsis: observations and hypotheses Complex immune dysregulation in COVID-19 patients with severe respiratory failure COVID-19: consider cytokine storm syndromes and immunosuppression The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of monocyte-derived macrophages and dendritic cells The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice Interaction of influenza virus with mouse macrophages Host defense mechanisms against influenza virus: interaction of influenza virus with murine macrophages in vitro Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages Pro-and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis Mycobacterial survival strategies in the phagosome: defence against host stresses Intracellular trafficking in mycobacterium tuberculosis and mycobacterium avium-infected macrophages HIF-1α Is an essential mediator of IFN-γ-dependent immunity to mycobacterium tuberculosis Infection with mycobacterium tuberculosis induces the Warburg effect in mouse lungs Cutting edge: mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis Mycobacterium tuberculosis limits host glycolysis and IL-1β by restriction of PFK-M via MicroRNA-21 Fumarase deficiency causes protein and metabolite succination and intoxicates mycobacterium tuberculosis An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism The effect of the host's iron status on tuberculosis Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages A major role for ferroptosis in mycobacterium tuberculosis-induced cell death and tissue necrosis Small RNA profiling in mycobacterium tuberculosis identifies mrsi as necessary for an anticipatory iron sparing response PPAR-α activation mediates innate host defense through induction of TFEB and lipid catabolism Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny Mycobacterium tuberculosis induces the MIR-33 locus to reprogram autophagy and host lipid metabolism In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor γ expression and activation: functions in inflammation, lipid metabolism, and pathogenesis Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor γ linking mannose receptor recognition to regulation of immune responses Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation Furthermore, post birth and during maturation, circulating monocytes do not significantly contribute to lung macrophage populations at homoeostasis 18 .
     • keywords: accumulation; acetylcysteine; acid; activation; activity; airway; alterations; alveolar; alveolar macrophages; ams; anti; associated; asthma; asthmatic; bacterial; bal; bleomycin; burden; cd206; cells; cellular; cftr; changes; chronic; clds; clearance; collagen; controls; copd; cycle; cystic; cystic fibrosis; cytokines; defence; delivery; development; disease; distinct; drug; effect; eicosanoid; energy; environment; epithelial; expression; fao; fatty; fibrosis; fig; function; glucose; glycolysis; healthy; high; homoeostasis; host; human; idiopathic; immune; impaired; induced; infected; infection; inflammation; inflammatory; inhibition; innate; intracellular; ipf; iron; itaconate; key; kinase; leading; levels; like; lipid; local; lung; lung disease; macrophages; major; matrix; metabolic; metabolites; metformin; mice; mitochondrial; model; monocytes; mouse; mtb; muc5b; mucus; murine; mycobacterium; nadph; new; nox; obstructive; oxidative; oxphos; oxygen; pathogenesis; pathogens; pathology; pathways; patients; phagocytosis; phenotype; potential; processes; production; protein; pulmonary; pulmonary disease; pulmonary fibrosis; reactive; recent; receptor; regulator; remodelling; reprogramming; resident; respiratory; responses; results; role; severe; species; specific; stress; studies; study; succinate; superoxide; surface; surfactant; synthesis; target; tca; tgf; therapeutic; therapies; therapy; tissue; treatment; tuberculosis; understanding; unique; vivo; wound
     • versions: original; plain text
110. cord-280374-yj0r4rwt
     • author: Jain, Richa
     • title: Hepatic sinusoidal-obstruction syndrome and busulfan-induced lung injury in a post-autologous stem cell transplant recipient
     • date: 2018-01-04
     • words: 2848
     • flesch: 38
     • summary: Marked atypia of the type II pneumocytes is a morphological clue in favour of busulfan induced lung injury in contrast to organizing bacterial pneumonia. The second pathology in this child which significantly contributed to his downhill course was busulfan induced lung injury.
     • keywords: absence; acute; bone; busulfan; candida; case; cell; child; clinical; cmv; common; day; diagnosis; disease; drug; early; features; fig; findings; fungal; hepatic; incidence; index; infections; infective; injury; ips; levels; liver; lung; marrow; neuroblastoma; normal; obstruction; occlusive; patients; pcj; pediatric; phase; pneumonia; post; presence; present; progressive; pulmonary; respiratory; right; sct; setting; sinusoidal; sos; stem; syndrome; transplantation; veno
     • versions: original; plain text
111. cord-280857-0o1ikwks
     • author: Goligher, Ewan C.
     • title: Clinical strategies for implementing lung and diaphragm-protective ventilation: avoiding insufficient and excessive effort
     • date: 2020-11-02
     • words: 6146
     • flesch: 20
     • summary: pathophysiology and clinical implications The injurious effects of elevated or nonelevated respiratory rate during mechanical ventilation Effects of short-term oxygenation changes on acute lung injury patients undergoing pressure support ventilation Effects of pressure ramp slope values on the work of breathing during pressure support ventilation in restrictive patients Volume-controlled ventilation does not prevent injurious inflation during spontaneous effort Neural control of mechanical ventilation in respiratory failure Comparison between neurally adjusted ventilatory assist and pressure support ventilation levels in terms of respiratory effort Neurally adjusted ventilatory assist versus pressure support ventilation in difficult weaning: a randomized trial Neurally adjusted ventilatory assist in acute respiratory failure: a randomized controlled trial Fifty years of research in ARDS. Monitoring and controlling respiratory muscle effort are major challenges in implementing lung and diaphragm-protective mechanical ventilation.
     • keywords: activity; acute; airway; approach; ards; assist; assisted; atrophy; benefit; blockade; breathing; changes; clinical; control; dependent; diaphragm; diaphragmatic; distress; drive; driving; dynamic; dyssynchrony; ecco; effects; effort; electrical; end; esophageal; excessive; extracorporeal; failure; flow; high; ill; ineffective; injury; inspiration; low; lung; mechanical; mechanical ventilation; monitoring; muscle; neuromuscular; oxygenation; pacing; partial; patients; peep; physiological; positioning; pressure; prone; protective; regional; respiratory; respiratory drive; reverse; risk; sedation; settings; severe; spontaneous; stimulation; strain; strategies; stress; studies; study; support; syndrome; system; tidal; time; transpulmonary; trial; triggering; ventilation; ventilatory; volume; wall; weakness
     • versions: original; plain text
112. cord-283078-vz98pp4h
     • author: Zakaria, Dina Mohamed
     • title: Histological and Physiological Studies of the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Bleomycin Induced Lung Fibrosis in Adult Albino Rats
     • date: 2020-10-22
     • words: 6561
     • flesch: 42
     • summary: METHODS: 30 adult female albino rats were distributed randomly into 4 groups; negative control group, Bleomycin induced lung fibrosis group, lung fibrosis treated with bone marrow-MSCs (BM-MSCs) and lung fibrosis treated with cell free media. Tissue Eng Regen Med DOI: 10.1007/s13770-020-00294-0 sha: doc_id: 283078 cord_uid: vz98pp4h BACKGROUND: Lung fibrosis is considered as an end stage for many lung diseases including lung inflammatory disease, autoimmune diseases and malignancy.
     • keywords: addition; albino; alveolar; alveoli; anti; architecture; area; assessment; bleomycin; blm; blood; bodies; bone; capillaries; cells; cellular; cfg; changes; collagen; colonies; comparison; complete; control; culture; current; cytokines; data; days; degenerative; deposition; diseases; dna; effect; electron; eng; epithelial; evident; examination; excessive; fev1; fibrosis; fibrotic; fig; free; function; fvc; group; histological; idiopathic; induced; infiltration; inflammatory; injection; injury; inter; limited; lumen; lung; lung fibrosis; marked; marrow; media; medicine; medium; mesenchymal; microscope; model; mrv; mscs; normal; number; pneumocytes; potential; pulmonary; rats; regen; results; sections; septa; septum; significant; stem; study; supplementary; surface; therapeutic; therapy; tissue; treated; treatment; trichrome; type; ultra
     • versions: original; plain text
113. cord-284332-p4c1fneh
     • author: Bosma, Karen J.
     • title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches
     • date: 2012-09-19
     • words: 14538
     • flesch: 29
     • summary: The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a metaanalysis of outcome data Efficacy of an expanded ventilator bundle for the reduction of ventilatorassociated pneumonia in the medical intensive care unit Continuous aspiration of subglottic secretions in the prevention of ventilatorassociated pneumonia in the postoperative period of major heart surgery Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial Thromboprophylaxis in medicalsurgical critically ill patients Stress ulcer prophylaxis in critically ill patients: resolving discordant meta-analyses Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effects of physical training on functional status in patients with prolonged mechanical ventilation Recent trends in acute lung injury mortality: 1996-2005 Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Effect of prone positioning in patients with acute respiratory distress syndrome: a metaanalysis Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis1 Hemodynamic and gas exchange response to inhaled nitric oxide and prone positioning in acute respiratory distress syndrome patients High-frequency oscillatory ventilation in adults: the Toronto experience High-frequency oscillatory ventilation for adult patients with ARDS Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome Ketoconazole prevents acute respiratory failure in critically ill surgical patients A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: phase IIb, multicenter, randomized, placebo-controlled, clinical trial Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial The Beta-Agonist Lung Injury Trial (BALTI): a randomized placebo-controlled clinical trial Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (albuterol) for the treatment of acute lung injury Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome: Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group Bovine surfactant therapy for patients with acute respiratory distress syndrome Venticute in patients with pneumonia or aspiration of gastric contents and intubation/ventilation/oxygenation impairment (BY2001/M1-007) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Arachidonic acid remodeling in human inflammatory cells migrating to the lung in vivo Recent advances in genetic predisposition to clinical acute lung injury Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients?
     • keywords: acid; activation; activity; acute; acute lung; acute respiratory; administration; adult; ali; alveolar; analysis; angiotensin; animal; antioxidant; apoptosis; ards; ards patients; ardsnet; associated; barrier; benefit; calfactant; capillary; care; causes; cells; circulation; clearance; clinical; control; corticosteroids; csf; damage; date; day; days; development; diagnosis; difference; direct; disease; distress; distress syndrome; dose; drug; dysfunction; early; effect; effective; efficacy; endothelial; epithelial; established; evidence; exogenous; expression; exudative; factor; failure; fatty; fibroproliferative; fluid; free; function; group; high; hours; human; icu; iii; ill; important; improved; indirect; inflammation; inflammatory; inhibitors; injury; insult; ketoconazole; large; late; likely; low; lower; lung; lung injury; macrophage; mechanical; mechanisms; mediators; meta; model; mortality; multiple; need; neutrophil; number; oedema; ongoing; organ; outcome; oxygenation; patients; pharmacotherapy; phase; placebo; pneumonia; population; potential; ppar; prevention; prior; prophylactic; proteins; pulmonary; randomized; ratio; rct; recent; receptor; recombinant; release; research; resolution; respiratory; respiratory distress; response; results; review; risk; role; rosiglitazone; safety; sepsis; septic; severe; shock; significant; single; specific; strategies; studies; study; surfactant; syndrome; system; systemic; therapies; therapy; tidal; tissue; treatment; trial; use; ventilation
     • versions: original; plain text
114. cord-284974-e7vl774c
     • author: Filipovic, N.
     • title: Abrupt Deterioration of COVID-19 Patients and Spreading of SARS COV-2 Virions in the Lungs
     • date: 2020-11-02
     • words: 796
     • flesch: 53
     • summary: (a) Suppose some part of the lung is initially infected by inhaled SARS COV-2 virus (in this example, we assume that the left upper lobe is initially infected). Clinically, severe SARS COV-2 infections exhibit multi-region patchy patterns of ground-glass opacity (GGO) throughout the lungs detected by computed tomography (CT).
     • keywords: abrupt; airflow; airways; bioaerosols; covid-19; deterioration; figure; infected; infection; initial; laden; lungs; particles; virus
     • versions: original; plain text
115. cord-285270-amh99u0j
     • author: Husain, Shahid
     • title: A 2010 working formulation for the standardization of definitions of infections in cardiothoracic transplant recipients
     • date: 2011-03-17
     • words: 4681
     • flesch: 21
     • summary: A randomized trial Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation An official ATS/ IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases Tuberculosis after solid-organ transplant: incidence, risk factors, and clinical characteristics in the RESITRA (Spanish Network of Infection in Transplantation) cohort Tuberculosis in solidorgan transplant recipients: consensus statement of the group for the study of infection in transplant recipients (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology Human metapneumovirus in lung transplant recipients and comparison to respiratory syncytial virus Impact after isolated lung transplantation International consensus guidelines on the management of cytomegalovirus in solid organ transplantation Cytomegalovirus viremia in lung transplant recipients receiving ganciclovir and immune globulin Bronchioloalveolar lavage in the diagnosis of CMV pneumonitis in lung transplant recipients: an immunocytochemical study Quantification of cytomegalovirus DNA in BAL fluid: a longitudinal study in lung transplant recipients Predictive value of cytomegalovirus DNA detection by polymerase chain reaction in blood and bronchoalveolar lavage in lung transplant patients Clinical utility of cytomegalovirus viral load in bronchoalveolar lavage in lung transplant recipients Correlation between viral loads of cytomegalovirus in blood and bronchoalveolar lavage specimens from lung transplant recipients determined by histology and immunohistochemistry Evaluation of interleukin-6 and interleukin-10 in lung transplant patients with human cytomegalovirus infection Human cytomegalovirus load in plasma and bronchoalveolar lavage fluid: a longitudinal study of lung transplant recipients Detection of CMV pneumonitis after lung transplantation using PCR of DNA from bronchoalveolar lavage cells Fungal infection in lung transplantation Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET) Epidemiology and outcome of invasive fungal infections in solid organ transplant recipients Anastomotic infections in lung transplant recipients Unique characteristics of fungal infections in lung transplant recipients Prospective assessment of Platelia Aspergillus galactomannan antigen for the diagnosis of invasive aspergillosis in lung transplant recipients Diagnosis of invasive aspergillosis using a galactomannan assay: a meta-analysis Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen Histoplasmosis in solid organ transplant recipients Histoplasmosis in solid organ transplant recipients: 10 years of experience at a large transplant center in an endemic area Disseminated coccidioidomycosis in a liver transplant recipient with negative serology: use of polymerase chain reaction Performance characteristics of the platelia Aspergillus enzyme immunoassay for detection of Aspergillus galactomannan antigen in bronchoalveolar lavage fluid Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients Diagnosis of invasive aspergillosis in lung transplant recipients by detection of galactomannan in the bronchoalveolar lavage fluid Evaluation of a (1¡3)-beta-D-glucan assay for diagnosis of invasive fungal infections The (1,3)␤-D-glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation Pulmonary aspergillosis in cystic fibrosis lung transplant recipients Saprophytic fungal infections and complications involving the bronchial anastomosis following human lung transplantation Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients Prospective assessment of Platelia Aspergillus galactomannan antigen for the diagnosis of invasive aspergillosis in lung transplant recipients Voriconazole prophylaxis in lung transplant recipients Aspergillus colonization of the lung allograft is a risk factor for bronchiolitis obliterans syndrome Antifungal prophylaxis with voriconazole or itraconazole in lung transplant recipients: hepatotoxicity and effectiveness Aspergillus infections in lung transplant recipients: risk factors and outcome Fungal infections after lung transplantation
     • keywords: acute; antigen; aspergillosis; aspergillus; bacterial; bal; bronchiolitis; bronchoalveolar; category; centers; clinical; cmv; colonization; community; criteria; cttx; culture; cytomegalovirus; data; definitions; detection; diagnosis; disease; early; fluid; fungal; fungal infections; galactomannan; group; guidelines; heart; histologic; immunocompromised; impact; infections; invasive; lavage; lung; lung transplant; lung transplantation; management; non; obliterans; organ; pathogenic; patients; pneumonia; presence; prior; probable; recipients; recovery; rejection; research; respiratory; risk; single; society; solid; specific; spp; studies; study; syndromes; tracheobronchitis; transplant; transplant recipients; transplantation; unique; use; viral
     • versions: original; plain text
116. cord-286771-77hs34jm
     • author: Cruces, Pablo
     • title: A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
     • date: 2020-08-10
     • words: 5936
     • flesch: 35
     • summary: We showed preliminary experimental data that regional lung strain and heterogeneity can be identified in acutely injured lungs under unassisted spontaneous breathing. The role of three-dimensionality and alveolar pressure in the distribution and amplification of alveolar stresses Does regional lung strain correlate with regional inflammation in acute respiratory distress syndrome during nonprotective ventilation?
     • keywords: acute; acute respiratory; alveolar; analysis; applied; approach; ards; arf; authors; biomechanical; breathing; cannula; care; clinical; cov2; covid-19; damage; deformation; disease; distress; early; effort; end; experimental; expression; failure; fig; flow; function; global; group; healthy; heterogeneity; hfnc; high; hypoxemic; increase; induced; inflammation; injury; intubation; invasive; like; low; lung; lung injury; mechanical; mechanisms; model; mortality; nasal; niv; non; noninvasive; oxygen; patients; position; pressure; progression; prone; pulmonary; regional; regions; respiratory; respiratory failure; review; role; sars; severe; sili; spontaneous; strain; stress; study; subjects; support; syndrome; therapy; tidal; tissue; type; use; ventilation; vili; volume; volumetric
     • versions: original; plain text
117. cord-287622-xnksvy21
     • author: Carpagnano, Giovanna E
     • title: Aspergillus spp. colonization in exhaled breath condensate of lung cancer patients from Puglia Region of Italy
     • date: 2014-02-18
     • words: 2991
     • flesch: 41
     • summary: Given the recent interest in the infective origin of lung cancer, with this preliminary study we aim to give our small contribution to this field of research by analysing the fungal microbiome of the exhaled breath condensate of lung cancer patients from Puglia, a region of Italy. The results confirmed the high percentage of fungal colonization of the airways of lung cancer patients from Puglia, suggesting the need to conduct further analyses in this field in order to evaluate the exact pathogenetic role of these fungi in lung cancer as well as to propose efficient, empirical therapy.
     • keywords: agar; airways; analysis; aspergillus; breath; bronchial; brushing; cancer; cancer patients; clinical; colonization; condensate; data; diagnosis; ebc; field; fungal; fungi; habit; healthy; human; infections; italy; lung; lung cancer; microbiome; niger; non; ochraceus; paired; patients; penicillium; positivity; potential; preliminary; puglia; pulmonary; region; results; role; sample; smoking; species; stage; studies; study; subjects; time
     • versions: original; plain text
118. cord-288371-uyj4iske
     • author: Arrieta, Oscar
     • title: Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: The THOCOoP cooperative group
     • date: 2020-06-20
     • words: 6676
     • flesch: 36
     • summary: patients with advanced non-small-cell lung cancer and poor performance status Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial) Telemedicine for cancer patients during COVID-19 pandemic: between threats and opportunities Hyperprogressive Disease in Patients With Advanced Non-Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy Immune-related adverse events with immune checkpoint inhibitors in thoracic malignancies: focusing on non-small cell lung cancer patients Characteristics and outcomes of small cell lung cancer patients diagnosed during two lung cancer computed tomographic screening programs in heavy smokers American College of Chest Physicians evidence-based clinical practice guidelines A Meta-Analysis of Thoracic Radiotherapy for Small-Cell Lung Cancer Systematic review evaluating the timing of thoracic radiation therapy in combined modality therapy for limited-stage small-cell lung cancer Time between the first day of chemotherapy and the last day of chest radiation is the most important predictor of survival in limited-disease small-cell lung cancer Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission Carboplatin-or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer Role of thoracic consolidation radiation in extensive stage small cell lung cancer: Relevant information has emerged regarding the higher risk of poor outcomes in lung cancer patients.
     • keywords: adjuvant; advanced; analysis; available; benefit; cancer; carboplatin; care; cases; cell; cell lung; chemoradiation; chemotherapy; china; cisplatin; clinical; consensus; coronavirus; covid-19; current; disease; early; evidence; experts; extensive; fees; group; guidelines; health; high; higher; immunotherapy; impact; inhibitors; limited; line; luis; lung; lung cancer; malignant; mesothelioma; meta; months; mortality; nivolumab; non; oncology; outcomes; pandemic; patients; pemetrexed; personal; phase; pleural; pneumonitis; questions; r n; radiation; radiotherapy; randomised; rate; recommendation; regimens; results; review; risk; scenario; sequential; setting; small; small cell; stage; standard; status; study; surgery; survival; symptoms; systematic; thoracic; time; total; toxicity; treatment; trial; use; voting; weekly
     • versions: original; plain text
119. cord-289103-6i7wf41w
     • author: McElyea, Christine
     • title: Lung ultrasound artifacts in COVID-19 patients
     • date: 2020-08-25
     • words: 1761
     • flesch: 44
     • summary: Reply Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol Covid-19 does not lead to a Typical acute respiratory distress syndrome Usefulness of ultrasound lung comets as a nonradiologic sign of extravascular lung water The role of ultrasound lung artifacts in the diagnosis of respiratory diseases Effectiveness of rapid lung ultrasound training program for gynecologists and obstetricians managing pregnant women with suspected COVID-19 Social consequences of COVID-19 in a low resource setting in Sierra Leone, West Africa Lung ultrasound is an essential tool in identifying lung disease and most practitioners will be able to identify pathology not visible on chest X-Ray
     • keywords: admission; anterior; areas; artifacts; bedside; care; chest; coronavirus; covid-19; day; disease; early; exposure; failure; findings; flow; interstitial; lung; pandemic; patients; pebbles; pneumonia; precautions; ray; respiratory; shred; signs; status; ultrasound; zones
     • versions: original; plain text
120. cord-290226-rtoasm2l
     • author: Scassellati, Catia
     • title: Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders
     • date: 2020-08-15
     • words: 15592
     • flesch: 33
     • summary: This network regulates endogenous cellular defense mechanisms, and involves redox sensitive genes such as members of the Heat Shock Proteins (HSP) family (heme-oxigenase HO-1, Hsp70), but also sirtuins and the thioredoxin (Trx)/thioredoxin reductase (TrxR1) system (Calabrese, V. et al., 2010) . When O3 is administrated, it dissolves immediately in the plasma/serum and it reacts with PUFA (polyunsaturated fatty acids), leading to the formation of the two fundamental messengers: hydrogen peroxide (H2O2) as a ROS and 4-hydroxynonenal (4HNE) as a lipid oxidation product J o u r n a l P r e -p r o o f (LOP) (Bocci, V. et al., 1998) (Figure 1 ).
     • keywords: 2012; acid; activation; activities; activity; adenosine; administration; advanced; aging; alanine; alpha; alterations; alzheimer; aminotransferase; antioxidant; apoptosis; apoptotic; applications; aspartate; associated; ast; atpase; bax; biological; biomarkers; blood; brain; bun; calabrese; cat; catalase; cell; cellular; central; changes; chen; clinical; cognitive; control; creatinine; daily; damage; days; decrease; dehydrogenase; dependent; different; disease; dismutase; disorders; dna; dose; effect; enzymes; et al; evidence; expression; factor; figure; free; function; genes; glutathione; group; growth; gsh; gssg; heart; heme; hepatic; histological; histopathological; ho-1; human; hypoxia; increase; index; induced; inducible; inflammation; inflammatory; injury; inos; insufflations; intensity; intraperitoneal; ischemia; kidney; lactate; ldh; levels; like; lipid; liu; liver; loss; low; lungs; major; malondialdehyde; manner; mda; mechanisms; medicine; mild; mitochondrial; model; molecular; molecule; morphology; mpo; myeloperoxidase; nds; necrosis; network; neurodegenerative; neuronal; neurons; new; nitric; nitrogen; nrf2; nuclear; oxidation; oxidative; oxidative stress; oxygen; oxygen.reduction; ozone; ozone oxidative; pathway; patients; peroxidase; peroxidation; phosphatase; plasma; polyphenols; potential; preconditioning; principal; processes; products; pronounced; protein; r n; rat; rats; reaction; reactive; rectal; redox; reduced; reduction; regulation; related; renal; reperfusion; response; results; review; role; sdh; serum; shock; signalling; significant; single; sod; status; stimulation; stress; studies; study; substances; succinate; superoxide; synthase; systems; table; tbars; therapeutic; therapy; thiobarbituric; time; tissue; tnf; total; treatment; triphosphatase; tubular; tumor; urea; vitagene; vitro; wang
     • versions: original; plain text
121. cord-290233-5skk3nj4
     • author: Wang, K.
     • title: Imaging manifestations and diagnostic value of chest CT of coronavirus disease 2019 (COVID-19) in the Xiaogan area
     • date: 2020-03-23
     • words: 3204
     • flesch: 45
     • summary: According to the latest version of the COVID-19 diagnosis and treatment plan issued by the Ministry of Health, lung CT is the main diagnostic method for COVID-19 suspected cases and one of the leading observation indicators for judging whether a patient can be discharged. Therefore, lung CT has an irreplaceable role in the screening and diagnosis of COVID-19, monitoring disease progression, and assessing whether the patient can be discharged.
     • keywords: acid; admission; cases; characteristics; chest; clinical; consolidation; coronavirus; correlation; covid-19; data; density; diagnosis; disease; distribution; epidemiological; examination; ggo; history; imaging; lesions; lung; lymphocyte; manifestations; negative; nucleic; patients; pneumonia; positive; present; results; sign; spo; stage; study; test; time; viral; wuhan; zone
     • versions: original; plain text
122. cord-290677-3gdcyrrz
     • author: De Virgiliis, Francesco
     • title: Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19
     • date: 2020-08-25
     • words: 6117
     • flesch: 22
     • summary: These cells show distinct transcriptional signatures, including CD169 + CD11c − and MHCII hi , as well as high expression of genes involved in communication with nerve cells, such as C1q and CX3CR1. This, in turns, disrupts mitochondrial metabolism and results in permanent neurolysis, making this drug potentially toxic for nerve cells and pulmonary neuroimmune homeostasis.
     • keywords: ace2; acetylcholine; activity; acute; addition; afferent; ageing; airway; angiotensin; antagonists; anti; ards; bronchoconstriction; cd8; cells; cgrp; cholinergic; clinical; control; coronavirus; cov-2; covid-19; cytokines; dependent; disease; distress; effector; expression; failure; fibres; fig; function; ganglia; gene; heart; high; human; il-6; immune; individuals; infected; infection; inflammation; inflammatory; influenza; innervation; levels; lung; macrophages; modulation; mucus; muscarinic; nams; nerve; nervous; neuroimmune; neuronal; neurons; older; outcomes; parasympathetic; pathway; patients; people; potential; pro; pulmonary; receptor; related; release; respiratory; response; role; sars; sensory; severe; severity; specific; stimulation; storm; substance; symptoms; syndrome; system; tissue; tnf; trachea; tract; vagal; vagus; vagus nerve; vasodilation; viral; virus; vns
     • versions: original; plain text
123. cord-291145-rdg31p17
     • author: Rice, Shawn J.
     • title: Guidance on the clinical management of E-cigarette or Vaping Associated Lung Injury (EVALI)?
     • date: 2020-08-29
     • words: 2899
     • flesch: 38
     • summary: Using bronchoalveolar-lavage (BAL) fluid from EVALI patients and healthy donors who have not used THC-containing products, researchers used isotope dilution mass spectrometry and identified vitamin E acetate in over 90% of EVALI cases versus none in the healthy controls. In this report, we present a comprehensive review of the clinical characteristics and features of EVALI patients and present guidelines for patient care and management to inform and navigate clinicians who may encounter these patients in their clinical practice.
     • keywords: acetate; agents; bronchoalveolar; cases; cause; cdc; characteristics; cigarette; clinical; clusters; covid-19; disease; electronic; evali; features; findings; fluid; health; important; injury; laden; lavage; liquids; lung; macrophages; management; nicotine; outbreak; patients; potential; products; pulmonary; report; respiratory; rise; severe; states; studies; symptoms; table; thc; use; vaping; vitamin
     • versions: original; plain text
124. cord-292862-ezrkg0dc
     • author: Myerson, Jacob W.
     • title: Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation Diagnosis and Treatment
     • date: 2020-04-18
     • words: 14319
     • flesch: 42
     • summary: Our data thus indicate that NAP tropism for neutrophils in inflamed mouse lungs may be recapitulated in human lungs. 6, 10, 14, 18 Single cell suspensions prepared from mouse lungs were probed by flow cytometry to further characterize pulmonary neutrophils in naïve mice and in mice following LPS-induced inflammation.
     • keywords: 400xg; accumulation; acute; administration; albumin; analysis; anesthetized; ansa; anti; antibody; ards; associated; azide; bacteria; bal; bare; bars; biodistributions; blood; buffer; catheter; cd45; cells; coli; composition; concentration; conjugation; contrast; control; cutoff; cytometry; data; dbco; dbco(20x)-igg; delivery; dextran; diameter; different; dose; drug; edema; effects; excess; exposure; facs; ferritin; figure; flow; fluid; fluorescent; fold; free; gfp; green; high; hours; human; human lungs; hydrophobic; igg; igg liposomes; images; imaging; induced; inflamed; inflamed lungs; inflammation; inflammatory; initial; injection; injured; injured lungs; injury; interactions; intravascular; kda; ketamine; ldng; leukocytes; levels; lipid; liposomes; lps; lps injury; lungs; ly6; lysozyme; marginated; marginated neutrophils; mice; minutes; model; mouse; nanogels; nanoparticles; nanostructures; naps; naïve; naïve lungs; naïve mice; nebulized; neutrophils; nhs; nps; organization; pbs; perfused; polystyrene; poni; positive; protein; pulmonary; reaction; regions; results; room; samples; sata; serum; signal; significant; single; size; solutions; specificity; spect; staining; structure; studies; study; supplementary; supplementary figure; supramolecular; surface; suspensions; table; targeting; temperature; tissue; treatment; tropism; types; uptake; vascular; vivo; xylazine
     • versions: original; plain text
125. cord-295156-trzkb9ne
     • author: Cheong, Dorothy H.J.
     • title: Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases
     • date: 2020-05-13
     • words: 6287
     • flesch: 39
     • summary: The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation Human embryonic lung fibroblasts treated with artesunate exhibit reduced rates of proliferation and human cytomegalovirus infection in vitro Inhibition of autophagy by chloroquine potentiates synergistically anti-cancer property of artemisinin by promoting ROS dependent apoptosis Dried leaf Artemisia annua efficacy against nonsmall cell lung cancer Synthesis and in vitro antitumor evaluation of dihydroartemisinincinnamic acid ester derivatives Dihydroartemisinin sensitizes Lewis lung carcinoma cells to carboplatin therapy via p38 mitogen-activated protein kinase activation Dihydroartemisinin and gefitinib synergistically inhibit NSCLC cell growth and promote apoptosis via the Akt/mTOR/STAT3 pathway Ionizing radiation potentiates dihydroartemisinininduced apoptosis of A549 cells via a caspase-8-dependent pathway Artesunate enhances radiosensitivity of human non-small cell lung cancer A549 cells via increasing NO production to induce cell cycle arrest at G2/M phase Artemisinin-Daumone Hybrid Inhibits Cancer Cell-Mediated Osteolysis by Targeting Cancer Cells and Osteoclasts In vitro and in vivo inhibition of tumor cell viability by combined dihydroartemisinin and doxorubicin treatment, and the underlying mechanism The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells Dihydroartemisinin Sensitizes Human Lung Adenocarcinoma A549 Cells to Arsenic Trioxide via Apoptosis Synergistic induction of apoptosis in A549 cells by dihydroartemisinin and gemcitabine Transferrin overcomes drug resistance to artemisinin in human small-cell lung carcinoma cells Dihydroartemisinin alleviates oxidative stress in bleomycininduced pulmonary fibrosis Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma Effects of artesunate on cigarette smoke-induced lung oxidative damage in mice and the expression of Nrf2 and the possible mechanism Artesunate Attenuates Lung Injury in Paraquat-Intoxicated Rats via Downregulation of Inflammatory Cytokines Artesunate Inhibits Renal Ischemia Reperfusion-Stimulated Lung Inflammation in Rats by Activating HO-1 Pathway. Artemisinin, Dihydroartemisinin, Artemether and Artesunate, in Milestones in Drug Therapy Molecular modes of action of artesunate in tumor cell lines The anti-malarial artesunate is also active against cancer Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes The antiviral activities of artemisinin and artesunate The selectivity of artemisinin-based drugs on human lung normal and cancer cells Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/beta-catenin signaling Dihydroartemisinin inhibits cell proliferation via AKT/GSK3beta/cyclinD1 pathway and induces apoptosis in A549 lung cancer cells
     • keywords: a-1; a549; able; activation; activity; acute; addition; adenocarcinoma; aif; airway; akt; allergic; anti; apoptosis; apoptotic; arrest; artemisinins; artesunate; astc; asthma; bak; bax; bleomycin; cancer; caspases; cells; chloroquine; colleagues; combination; covid-19; cycle; dependent; derivatives; dha; different; dihydroartemisinin; diseases; drug; effects; epithelial; expression; factor; fibrosis; growth; human; induced; infections; inflammation; inflammatory; inhibited; inhibition; injury; invasion; kinase; levels; like; lines; lung; malarial; metastasis; mice; model; mouse; muscle; non; oxidative; pathway; patients; people; potential; profile; proliferation; properties; protein; pulmonary; rats; reduction; release; respiratory; respiratory diseases; small; studies; study; therapeutic; toxicity; treatment; tumour; viral; xenograft
     • versions: original; plain text
126. cord-300124-voyjcjzw
     • author: Soldati, Gino
     • title: Reply to colorimetric triage for patients with COVID‐19
     • date: 2020-08-27
     • words: 703
     • flesch: 32
     • summary: Proposal for international standardization of the use of lung ultrasound for patients with COVID-19: a simple, quantitative, reproducible method Artifactual lung ultrasonography: it is a matter of traps, order, and disorder Physical mechanisms providing clinical information from ultrasound lung images: hypotheses and early confirmations The role of ultrasound lung artifacts in the diagnosis of respiratory diseases Lung ultrasonography may provide an indirect estimation of lung porosity and airspace geometry Contrast-enhanced ultrasound in patients with COVID-19: pneumonia, acute respiratory distress syndrome, or something else Lung ultrasonography for early management of patients with respiratory symptoms during COVID-19 pandemic Routine use of point-of-care lung ultrasound during the COVID-19 pandemic Ultrasonography in lung pathologies: new perspectives Time for new international evidence-based recommendations for point-of-care lung ultrasound Determination of a potential quantitative measure of the state of the lung using lung ultrasound spectroscopy Although LUS has low specificity, by detecting and assessing lung involvement in suspected or confirmed cases, it can support clinical suspicions and potentially play a role in managing decisions.
     • keywords: alterations; artifacts; clinical; colorimetric; covid-19; line; lung; lus; patients; pleural; score; scoring; system; triage; ultrasound; vertical
     • versions: original; plain text
127. cord-301935-0qjo94ty
     • author: Varma, Ratna
     • title: Current strategies and opportunities to manufacture cells for modeling human lungs
     • date: 2020-08-22
     • words: 10328
     • flesch: 27
     • summary: Studies exploiting PSC-derived lung culture models to explore the effect of drugs in human lung cells are therefore beginning to emerge. Directed differentiation of pluripotent stem cells is an important strategy to generate lung cells to create such models.
     • keywords: ability; aec; airway; alveolar; animal; approach; basal; bifurcation; biophysical; bmp4; branching; bud; buds; cancer; cell differentiation; cells; cellular; changes; chemical; ciliated; club; colony; complex; context; control; critical; cues; culture; current; cystic; days; dependent; development; differentiation; differentiation protocols; disease; distal; drug; dynamics; early; ecm; embryonic; embryonic stem; endoderm; engineering; epithelial; epithelial cells; example; expression; factor; fate; fetal; fgf10; fibroblast; fibrosis; filopodia; focal; foregut; formation; functional; future; generation; geometry; goblet; grooved; growth; high; human; human lung; human pluripotent; importance; induced; induction; key; like; limited; lineage; lung; lung development; markers; maturation; mature; mechanical; mechanism; mesenchymal; modeling; models; morphogenesis; morphology; mouse; multi; number; organization; organoids; pathway; patient; patterning; phenotypes; platform; pluripotent; pluripotent stem; populations; present; primary; primitive; progenitors; proliferation; protein; protocols; proximal; psc; pulmonary; r n; repair; respiratory; role; screening; self; shape; signaling; signals; single; size; sox2; sox9; spc; specific; stem; stem cells; structure; studies; study; substrate; surface; table; tension; tip; tips; tissue; topographical; topographies; topography; tube; types; u r; virus; vivo; weeks; wnt
     • versions: original; plain text
128. cord-306076-ygfnkgqp
     • author: Fujita, Yu
     • title: RNAi Therapeutic Platforms for Lung Diseases
     • date: 2013-02-06
     • words: 8427
     • flesch: 36
     • summary: Strategies for silencing human disease using RNA interference RNAi therapeutics: A potential new class of pharmaceutical drugs Small interfering RNA inhibits hepatitis B virus replication in mice RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice Chemical modification of siRNA siRNA and isRNA: Two edges of one sword Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells Inhibition of non-small cell lung cancer cell proliferation and tumor growth by vector-based small interfering RNAs targeting HER2/neu Rodriguez-Padilla, C. WT1 gene silencing by aerosol delivery of PEI-RNAi complexes inhibits B16-F10 lung metastases growth Inhibition of influenza virus production in virus-infected mice by RNA interference Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis Effective treatment of respiratory alphaherpesvirus infection using RNA interference A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus RNA interference: new therapeutics in allergic diseases Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease Suppression of plasminogen activator inhibitor-1 In general, both viral and non-viral vectors are being assessed for siRNA delivery to lung cells.
     • keywords: addition; airway; aln; alveolar; anti; applications; approaches; associated; asthma; barriers; cancer; cause; cells; cellular; chemical; chronic; cigarette; clinical; complex; conditions; copd; corticosteroids; degradation; delivery; development; diseases; drug; effective; effects; efficient; epithelial; evidence; expression; factor; fibrosis; function; future; gene; growth; human; important; induced; infection; inflammation; inflammatory; inhalation; inhaled; inhibition; inhibits; interference; intranasal; kinase; lipid; lung; lung cancer; lung diseases; major; mice; microrna; mimics; mirnas; molecular; molecules; mrna; mucus; multiple; naked; new; non; obstructive; oligonucleotides; particles; pathogenesis; patients; phase; potential; progression; promising; pulmonary; recent; receptor; regulation; respiratory; response; rnai; role; rsv; rsv01; significant; silencing; sirna; sirna delivery; size; small; smoke; smoking; specific; studies; syk; systemic; target; targeted; targeting; therapeutic; therapies; therapy; toxicity; tract; transfection; treatment; trial; tumor; use; vectors; viral; virus; vivo
     • versions: original; plain text
129. cord-306266-8qdrshz3
     • author: Scully, Crispian
     • title: Respiratory medicine
     • date: 2014-06-25
     • words: 13246
     • flesch: 40
     • summary: Respiratory infections must also be eradicated; sputum should first be sent for culture and sensitivity, but antimicrobials such as amoxicillin should be started without await ing results. Immunocompromised persons (e.g. those with human immunode ficiency virus/acquired immune deficiency syndrome [HIV/AIDS] and transplant recipients) and people with bronchiectasis or cystic fibrosis are also susceptible to respiratory infections by a range of opportun istic microbes.
     • keywords: -there; abscess; abscessus; active; acute; adequate; africa; aids; air; airflow; airways; alveolar; antibiotic; arterial; asia; aspiration; assessment; association; asthma; asthmatic; attacks; bacterial; benefit; best; biopsy; blood; breathing; breathlessness; bronchiectasis; bronchitis; bronchodilators; cancer; carbon; care; cases; cause; cells; cervical; chest; children; chronic; clinical; combination; common; complications; contact; contagious; control; copd; corticosteroids; cough; countries; culture; cystic; days; defects; dental; dental treatment; development; diagnosis; disease; disorders; drugs; dyspnoea; early; emphysema; evidence; exacerbations; example; exchange; exercise; exposure; failure; fatal; features; fever; fibrosis; fig; flow; following; frequent; function; gas; gastric; glands; healthcare; help; high; highincome; history; hiv; hospital; human; ige; igra; illness; immune; impaired; impairment; important; individuals; infected; infection; influenza; inhalation; inhaled; isoniazid; legionella; lesions; lower; ltot; lung; lymphadenopathy; main; maintenance; management; material; mdrtb; medical; milk; months; mortality; mott; mouth; mucus; muscle; mycobacteria; necessary; need; new; nodes; normal; obstruction; oedema; older; oral; oxygen; pain; patients; people; persons; pneumonia; poor; positive; possible; present; prevention; primary; production; pulmonary; radiography; rare; rate; recent; recurrent; release; respiratory; respiratory infections; response; result; rifampicin; risk; salivary; sarcoidosis; sars; secretions; september; severe; shortacting; significant; similar; skin; smoking; spirometry; spread; sputum; surgery; symptoms; syndrome; systemic; systems; table; test; testing; theophylline; therapy; tract; transmission; transplantation; treatment; tuberculin; tuberculosis; type; upper; vaccines; vap; ventilation; ventilatorassociated; viruses; water; weeks; wheeze; world; years; young
     • versions: original; plain text
130. cord-308071-1bk3xuwf
     • author: Lang, Christian
     • title: Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient
     • date: 2020-08-25
     • words: 2438
     • flesch: 38
     • summary: 11, 12 The case we present here extends the reports from China by showing that lung transplantation can be done in patients with positive RT-PCR results, provided that Vero cell cultures confirm non-infectivity. 15 As donor organs are a scarce resource, it is important to consider lung transplantation only for patients with irreversibly damaged lungs.
     • keywords: acute; antibodies; appendix; ards; blood; bronchoalveolar; case; cell; china; condition; covid-19; day; distress; donor; ecmo; extracorporeal; high; icu; infectivity; large; lavage; lobes; lung; lung transplantation; min; negative; option; patient; pcr; positive; postoperative; real; recovery; respiratory; samples; sars; severe; syndrome; test; therapy; time; transplantation; treatment; venovenous
     • versions: original; plain text
131. cord-308461-4lhh3du0
     • author: Ueki, Hiroshi
     • title: Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS
     • date: 2020-01-29
     • words: 8359
     • flesch: 35
     • summary: The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors T cell response in the lung following influenza virus infection Neutrophil trails guide influenza-specific CD8 + T cells in the airways Live imaging of influenza infection of the trachea reveals dynamic regulation of CD8 + T cell motility by antigen Imaging cell interaction in tracheal mucosa during influenza virus infection using two-photon intravital microscopy Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies Molecular determinants of virulence and stability of a reporter-expressing H5N1 influenza A virus Amino acid changes in PB2 and HA affect the growth of a recombinant influenza virus expressing a fluorescent reporter protein Live imaging of the lung A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre ransgene transmission Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre-and Flp-mediated recombination TrackMate: an open and extensible platform for single-particle tracking The role of neutrophils during mild and severe influenza virus infections of mice Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis The effects of acute neutrophil depletion on resolution of acute influenza infection, establishment of tissue resident memory (TRM), and heterosubtypic immunity Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanism Spectral imaging: principles and applications Multispectral imaging in biology and medicine: slices of life A robust and high-throughput Cre reporting and characterization system for the whole mouse brain Regulating the adaptive immune response to respiratory virus infection A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection Innate immunity to influenza virus infection Intravascular staining for discrimination of vascular and tissue leukocytes In vivo compartmental analysis of leukocytes in mouse lungs A study of the pulmonary circulation by the transillumination method Pulmonary capillary recruitment during airway hypoxia in the dog The behavior of the arterioles and capillaries of the lung Capillary recruitment during airway hypoxia: role of pulmonary artery pressure Capillaroscopic appearance of the pulmonary alveoli in the living dog Diffusing capacity of the lung during hypoxia: role of capillary recruitment Intrapulmonary blood flow redistribution during hypoxia increases gas exchange surface area The normal behavior of the pulmonary blood vessels with observations on the intermittence of the flow of blood in the arterioles and capillaries An experimental model for simultaneous quantitative analysis of pulmonary micro-and macrocirculation during unilateral hypoxia in vivo A thoracic window for observation of the lung in a living animal Microscopic observation of the lung in vivo Precapillary oxygenation contributes relevantly to gas exchange in the intact lung Pulmonary microcirculatory observations in vivo under physiological conditions Direct measurement of pulmonary capillary transit times Intravital laser confocal microscopy of pulmonary edema resulting from intestinal ischemia-reperfusion injury in the rat Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries Measurement of lung microvascular pressure in the intact anesthetized rabbit by the micropuncture technique Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance Capillary perfusion patterns in single alveolar walls Measurement of microhemodynamics in the ventilated rabbit lung by intravital fluorescence microscopy Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction Leukocyte kinetics in pulmonary microcirculation: intravital fluorescence microscopic study The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis Temporal capillary perfusion patterns in single alveolar walls of intact dogs Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice Sites of leukocyte sequestration in the pulmonary microcirculation CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses Contribution of selectins to leucocyte sequestration in pulmonary microvessels by intravital microscopy in rabbits Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli Leukocyte margination in alveolar capillaries: interrelationship with functional capillary geometry and microhemodynamics Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury
     • keywords: acute; aligna; aliquots; alveolar; analysis; anesthesia; animal; antibodies; antibody; approach; appropriate; available; behavior; blood; brightness; bsl3; capillary; cat; caution; cells; cellular; concentration; conditions; cover; cre; critical; dark; data; dendritic; different; disease; dyes; dynamics; e.g.; excitation; experimental; facility; fig; fluorescent; glass; green; high; i.v; image; imaging; imaging system; immune; infected; infection; inflammation; influenza; influenza virus; information; injury; intravital; laser; level; live; long; lung; methods; mice; microcirculation; microscopy; microtubes; min; model; mouse; multiple; neutrophil; observation; pbs; photon; photon excitation; photon imaging; place; pressure; protein; protocol; pulmonary; recruitment; red; refrigerator; reporter; research; respiratory; response; room; saline; sepsis; single; software; solution; spectra; spectrum; stacks; sterile; store; studies; study; suction; supplementary; surgical; system; table; thoracic; time; tissue; tokyo; turn; unit; vessels; virus; viruses; vivo; vivo imaging; wavelength; window; μl i.v
     • versions: original; plain text
132. cord-309722-04pp3lv0
     • author: Qiu, Yingshan
     • title: Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside
     • date: 2016-09-20
     • words: 13217
     • flesch: 36
     • summary: tablets Nanomedicine as an emerging platform for metastatic lung cancer therapy Aerosol gene delivery using viral vectors and cationic carriers for in vivo lung cancer therapy Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Dual expression of shAkt1 and Pdcd4 suppresses lung tumorigenesis in K-ras LA1 mice Suppression of lung cancer progression by biocompatible glycerol triacrylate-spermine-mediated delivery of shAkt1 Lentivirus-AIMP2-DX2 shRNA suppresses cell proliferation by regulating Akt1 signaling pathway in the lungs of AIMP2+/-Mice Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises Pulmonary codelivery of doxorubicin and siRNA by pH-sensitive nanoparticles for therapy of metastatic lung cancer A novel platform to enable inhaled naked RNAi medicine for lung cancer In vivo tumor targeting via nanoparticle-mediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA Modelling Myc inhibition as a cancer therapy Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells RPN2 gene confers docetaxel resistance in breast cancer Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer Co-delivery of chemosensitizing siRNA and an anticancer agent via multiple monocomplexation-induced hydrophobic association Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles Bcl-2 inhibitors: Targeting mitochondrial apoptotic pathways in cancer therapy Akt1 is an important mediator of cell growth, proliferation and survival of non-small cell lung cancer (NSCLC).
     • keywords: acid; activation; activity; acute; administration; aerosol; airway; akt1; allergic; aln; alveolar; antisense; antiviral; approach; asthma; autophagy; barriers; cancer; cells; cellular; challenge; chronic; clearance; clinical; complex; copd; ctgf; cytokines; death; delivery; deposition; development; different; disease; disorders; dna; drug; effect; effective; efficacy; escape; essential; expression; factor; fibrosis; following; functions; gene; growth; high; host; immune; infection; inflammation; inflammatory; influenza; inhalation; inhaled; inhibition; inhibitors; injury; interference; intracellular; intranasal; intratracheal; key; kinase; leading; lipid; long; lung; lung cancer; macrophages; major; management; mechanisms; metastatic; mice; model; molecules; mouse; mrna; mucus; multiple; naked; nanoparticles; need; new; non; novel; nucleic; pathogenesis; pathway; patients; pei; peptide; phase; potential; primary; production; promising; protein; pulmonary; pulmonary delivery; receptor; reduced; region; regulation; replication; resistance; respiratory; response; review; rnai; rnai molecules; rnai therapeutics; role; route; rsv; rsv01; serum; severe; short; signaling; significantly; silencing; sirna; sirna delivery; small; specific; structure; studies; study; suppression; surfactant; syk; syncytial; system; systemic; targeting; targets; term; tgf; therapeutic; therapy; tnf; transcription; transfection; treatment; tuberculosis; tumor; types; tyrosine; vectors; viral; virus; viruses; vitro; vivo
     • versions: original; plain text
133. cord-310840-h49dx92d
     • author: Eslamy, Hedieh K.
     • title: Pneumonia in Normal and Immunocompromised Children: An Overview and Update
     • date: 2011-09-30
     • words: 8285
     • flesch: 29
     • summary: CT is often used to further evaluate: (1) suppurative lung complications and to differentiate these from parapneumonic effusion/empyema; (2) patients with recurrent or chronic pneumonia and concern for an underlying lesion; and (3) immunocompromised children with noncontributory or confusing chest radiographs and clinical findings that could be secondary to lung infection. 12 Peltola and colleagues 13 recently published their experience with MR imaging of lung infections in children using free-breathing T2-weighted, short tau inversion recovery, and T1-weighted with fat saturation precontrast and postcontrast sequences.
     • keywords: abscess; acute; age; air; airspace; airway; appearance; aspiration; associated; atelectasis; atypical; bacterial; bilateral; body; box; bronchiectasis; bronchiolitis; cases; cause; cavitary; cavity; changes; chest; chest radiographs; children; chronic; clinical; common; complications; congenital; consolidation; constrictive; contrast; cystic; dense; diagnosis; diffuse; disease; effusion; empyema; evaluation; extent; failure; features; fibrosis; fig; findings; fistula; fluid; focal; foreign; fungal; gangrene; group; halo; hiv; host; hydrocarbon; imaging; immunocompromised; immunodeficiency; infants; infection; interstitial; large; lipoid; lower; lung; mimics; necrosis; neonatal; nodular; normal; oil; older; opacities; opacity; organism; parapneumonic; parenchyma; patients; pattern; pediatric; peripheral; pertussis; pie; pleural; pneumonia; presence; present; process; pulmonary; radiographs; rare; recurrent; respiratory; result; role; secondary; severe; sign; small; space; spectrum; subacute; suppurative; symptoms; syndromes; techniques; thoracic; tissue; tract; transplantation; trapping; treatment; tuberculosis; underlying; useful; viral; years
     • versions: original; plain text
134. cord-313431-swkcdvx8
     • author: Becerra-Diaz, Mireya
     • title: Androgen and Androgen Receptors as Regulators of Monocyte and Macrophage Biology in the Healthy and Diseased Lung
     • date: 2020-08-07
     • words: 14998
     • flesch: 29
     • summary: We have highlighted here how sex hormones contribute to changes in lung macrophage function that contribute to lung disease. Thus, testosterone appears to play a key immunoregulatory role in lung macrophages.
     • keywords: action; activation; activity; adaptive; adult; airway; allergic; alveolar; alveolar macrophages; analysis; androgen; androgen receptor; antigen; apoptosis; ars; asthma; asthmatic; atherosclerosis; binding; biological; biology; blood; bone; cancer; cd14; cells; cellular; changes; chemokine; chronic; cigarette; circulation; classical; concentrations; control; copd; critical; cytokine; dcs; decrease; deficiency; dehydroepiandrosterone; dendritic; dependent; development; dhea; dht; differences; different; differentiation; disease; donors; effects; epithelial; estradiol; estrogen; exposure; expression; factor; female; fibrosis; foam; function; gender; greater; healthy; high; higher; homeostasis; hormones; human; human monocytes; il-6; immune; immune cells; immune response; immunity; important; ims; incidence; increase; infection; inflammation; inflammatory; influenza; inhibits; innate; interstitial; key; klinefelter; levels; like; lipid; low; lower; lps; lung; lung cancer; lung disease; lung function; lung macrophages; ly6c; macrophages; male; mdms; mechanisms; men; metabolism; mice; models; modulate; modulation; molecular; monocytes; monocytic; mononuclear; mortality; mouse; murine; myeloid; non; number; observed; obstructive; pathogenesis; patients; pcos; peripheral; phenotype; polarization; populations; primary; production; prostate; protective; protein; pulmonary; rates; receptor; reduced; regulation; replacement; respiratory; responses; results; review; risk; role; serum; severe; sex; sex differences; sex hormones; signaling; similar; small; smoke; smoking; specific; states; steroids; studies; study; subpopulations; survival; susceptibility; syndrome; system; systemic; target; testosterone; therapy; tissue; tnf; treatment; tuberculosis; tumor; types; virus; women
     • versions: original; plain text
135. cord-313785-8tipkksu
     • author: d'Ettorre, Gabriella
     • title: Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19
     • date: 2020-07-07
     • words: 3790
     • flesch: 35
     • summary: The WHO, CDC, and FDA have not taken a position on the use of Tocilizumab in COVID-19, even though China's National Health Commission recommends it for use in COVID-19 patients but only if elevated IL-6 levels are present (15) . The collection of clinical data, examination, and nursing of COVID-19 patients is challenging for the risk of virus transmission.
     • keywords: 4th; 9th; alt; april; asthenia; axis; bacterial; bacteriotherapy; care; cells; clinical; continuous; coronavirus; covid-19; data; days; diarrhea; disease; dsm; failure; fever; formulation; group; gut; heme; ho-1; human; hydroxychloroquine; icu; infection; intensive; intestinal; invasive; involvement; lung; management; march; microbiota; ob+; oral; oral bacteriotherapy; oxygen; oxygenase-1; patients; positive; potential; pressure; proportion; report; respect; respiratory; results; risk; sars; severe; significant; study; subjects; supplemented; symptoms; time; tocilizumab; treatment; use; ventilation; virus
     • versions: original; plain text
136. cord-315085-rucfowvv
     • author: Sekulic, Miroslav
     • title: Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases
     • date: 2020-05-26
     • words: 5033
     • flesch: 40
     • summary: Sequencing of viral RNA from FFPE lung tissue from the case 1 autopsy showed mutations most consistent with a subset of the Western European Clade A2a (C3037T, C14408T, A23403G), 16 with mutations enriched in New York State A2a cases (C1059T and G25563T). Lung tissue samples from 2 non-SARS-CoV-2 patients with DAD were run as controls and were negative.
     • keywords: ace2; acute; admission; airways; alveolar; artery; associated; autopsies; autopsy; background; bilateral; blood; bronchi; case; cells; changes; chest; chronic; consistent; coronary; coronavirus; cov-2; covid-19; dad; day; days; death; detection; diffuse; disease; evidence; examination; failure; features; ffpe; findings; formalin; g11083; heart; image; infection; injury; kidneys; left; liver; lobe; lower; lung; lymph; mass; membrane; molecular; mutations; node; notable; novel; opacities; organs; oxygen; parenchyma; patchy; patient; pcr; positive; postmortem; pulmonary; renal; reported; respiratory; right; rna; roentgenogram; samples; sampling; sars; sections; sequencing; significant; spleen; study; testing; time; tissue; viral; virus; ×100
     • versions: original; plain text
137. cord-315948-o4uj3l8r
     • author: Kim, Se Yong
     • title: A Case of Statin-Induced Interstitial Pneumonitis due to Rosuvastatin
     • date: 2015-06-30
     • words: 1735
     • flesch: 37
     • summary: A computed tomography scan of the chest showed diffuse ill-defined ground glass opacity with septal line thickening in bilateral lung fields combined with several subpleural ground glass opacity nodules on admission. www.e-trd.org of statins: implications for cardiovascular event reduction Safety of statins: focus on clinical pharmacokinetics and drug interactions The safety of rosuvastatin as used in common clinical practice: a postmarketing analysis Dermatomyositis with lung involvement in a patient treated with simvastatin Polymyalgia, hypersensitivity pneumonitis and other reactions in patients receiving HMG-CoA reductase inhibitors: a report of ten cases A case of interstitial lung disease with atorvastatin (Tahor) and a review of the literature about these effects observed under statins Statins and interstitial lung disease: a systematic review of the literature and of food and drug administration adverse event reports Statin-induced lung injury: diagnostic clue and outcome Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches No potential conflict of interest relevant to this article was reported.
     • keywords: alveolar; appearance; bal; blood; case; chest; clinical; cytology; diagnosis; diffuse; disease; drug; findings; foamy; following; glass; ground; interstitial; lower; lung; macrophages; negative; normal; opacity; patient; radiologic; results; rosuvastatin; statins; steroid; symptoms; therapy
     • versions: original; plain text
138. cord-317993-012hx4kc
     • author: Movia, Dania
     • title: Preclinical Development of Orally Inhaled Drugs (OIDs)—Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?
     • date: 2020-07-24
     • words: 6888
     • flesch: 35
     • summary: The so-called lung-on-chip is a microfluidic-based in vitro system in which lung epithelial cells are grown on one side of a membrane, and stromal cells on the other surface. Semin Heuze-Vourc'h, N. Innovative preclinical models for pulmonary drug delivery research Options for modeling the respiratory system: Inserts, scaffolds and microfluidic chips A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall Use of porous membranes in tissue barrier and co-culture models A novel electrospun biphasic scaffold provides optimal three-dimensional topography for in vitro co-culture of airway epithelial and fibroblast cells Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke Altered generation of ciliated cells in chronic obstructive pulmonary disease Primary epithelial cell models for cystic fibrosis research Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus Regeneration of the lung: Lung stem cells and the development of lung mimicking devices In vitro generation of human pluripotent stem cell derived lung organoids A three-dimensional model of human lung development and disease from pluripotent stem cells Modelling Cryptosporidium infection in human small intestinal and lung organoids Use of three-dimensional organoids and lung-on-a-chip methods to study lung development, regeneration and disease Organoids as a Powerful Model for Respiratory Diseases Lung-On-A-Chip Technologies for Disease Modeling and Drug Development Reconstituting organ-level lung functions on a chip A human breathing lung-on-a-chip A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice A lung/liver-on-a-chip platform for acute and chronic toxicity studies A 3D human lung-on-a-chip model for nanotoxicity testing Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: A biopharmaceutical perspective Impaired Wound Healing of Alveolar Lung Epithelial Cells in a Breathing Lung-On-A-Chip Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics Biomimetic human lung-on-a-chip for modeling disease investigation Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung Modeling the lung:
     • keywords: absorption; account; action; administration; aerosol; air; airway; ali; alveolar; animal; animal models; asthma; authors; cancer; cell; chip; chronic; clearance; complex; conditions; copd; cultures; current; cystic; delivery; deposition; development; devices; dimensional; disease; dose; droplets; drug; effective; effects; efficacy; epithelial; example; fact; feature; fibrosis; human; human lung; impact; inflammation; inhalation; inhaled; inhalers; level; limitations; liquid; lung; mechanisms; metabolism; methods; modeling; models; mucociliary; mucus; nams; new; non; obstructive; oid; oids; organoids; particles; patients; pharmaceutical; preclinical; predictive; products; pulmonary; recent; regulatory; research; respiratory; responses; role; screening; small; specific; studies; study; systemic; systems; testing; therapeutic; therapy; tissue; toxicity; tract; treatment; type; use; value; velocity; vitro; vivo
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139. cord-322756-ouvn71r9
     • author: Chow, Michael Y.T.
     • title: Inhaled RNA Therapy: From Promise to Reality
     • date: 2020-09-04
     • words: 7289
     • flesch: 36
     • summary: In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors.
     • keywords: acids; activity; administration; aerodynamic; aerosol; aln; animal; approach; associated; asthma; cancer; cationic; cell; cellular; chitosan; clinical; cystic; degradation; delivery; delivery vectors; development; different; diseases; dose; drug; dry; effective; efficiency; epithelial; expression; fibrosis; figure; formulation; function; gene; healthy; high; hybrid; infection; inhalation; inhaled; injury; intratracheal; lipid; liquid; low; lung; macrophages; major; mice; model; mrna; naked; naked rna; nanoparticles; natural; nebulization; non; patients; pei; peptides; phase; polymer; potential; powder; protein; pulmonary; pulmonary delivery; recent; respiratory; rna; rna delivery; rsv; rsv01; safe; silencing; single; sirna; small; specific; stability; studies; successful; surfactant; synthetic; system; table; targeting; therapeutic; therapy; toxicity; transfection; translation; treatment; trial; types; uptake; use; vectors; virus; vivo
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140. cord-323566-jck799zq
     • author: Cheung, Oi-Yee
     • title: Acute Lung Injury
     • date: 2017-11-05
     • words: 8319
     • flesch: 34
     • summary: Other histologic features of acute lung injury include intraalveolar fibrin, organization, interstitial edema, and reactive pneumocytes. Diffuse alveolar damage and other histologic features of acute lung injury are nonspecific as to etiology, and once identified require the pathologist to search the biopsy for further features that may help identify a specific etiology.
     • keywords: acute; acute lung; acute respiratory; adenovirus; afop; airspace; alveolar; amiodarone; answer; ards; arthritis; associated; atypical; biopsy; bleomycin; bronchiolitis; cases; cause; cells; changes; characteristic; children; chronic; clinical; common; connective; dad; damage; diagnosis; differential; diffuse; disease; distress; drug; edema; eosinophilic; epithelial; eslide; etiology; examination; fatal; features; fibrin; fibroblastic; fibrosis; fig; findings; following; hemorrhage; high; histologic; histopathologic; history; hyaline; idiopathic; immunocompromised; inclusions; infection; infiltrates; inflammatory; injury; interstitial; interstitial pneumonia; intraalveolar; intranuclear; lung; lung disease; lung injury; lupus; macrophages; manifestations; membranes; methotrexate; necrosis; numerous; onset; organisms; organization; organizing; oxygen; pathology; patients; pattern; phase; pneumocytes; pneumonia; pneumonitis; presence; present; proliferation; pulmonary; radiation; reactive; related; respiratory; rheumatoid; severe; shock; shows; significant; specific; stains; studies; study; surgical; syndrome; systemic; therapy; time; tissue; toxicity; type; viral; virus
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141. cord-328266-bjs6ywlf
     • author: Gunasekaran, Muthukumar
     • title: Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection
     • date: 2020-04-30
     • words: 4911
     • flesch: 41
     • summary: The Ab levels for lung SAgs, optical density of exosomes containing lung SAgs, and viral antigens between RVI LTxRs and controls were compared using Mann−Whitney or two-tailed Student's t-test, as indicated. Mice injected with exosomes isolated from stable LTxRs showed increased frequency of IL-10−producing T cells compared with mice immunized with RVI exosomes.
     • keywords: 20s; abs; allograft; analysis; antibodies; antigens; cells; cellular; chronic; clad; col; controls; coronavirus; density; dysfunction; exosomes; fibrosis; figure; human; immune; immunized; immunoblot; increased; infection; ka1; ltxrs; lung; lung sags; mean; mice; optical; patients; presence; proteasome; rejection; respiratory; responses; results; rhinovirus; risk; rsv; rvi; sags; samples; self; serum; significant; specific; stable; stable ltxrs; study; symptomatic; transplant; transplantation; viral; viral antigens
     • versions: original; plain text
142. cord-329066-9xo5zztv
     • author: Yuan, Kai
     • title: FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma
     • date: 2020-03-13
     • words: 5146
     • flesch: 44
     • summary: Lung cancer is generally classified into two kinds of histopathology groups: non-small cell lung cancer and small cell lung cancer (Latimer, 2018) . Lung adenocarcinoma is the most common type of pulmonary cancer.
     • keywords: activities; adenocarcinoma; adjacent; antigen; antitumor; cancer; cd4; cd8; cells; correlation; ctls; cytotoxic; database; dcs; dendritic; effects; egfr; expression; factor; fgl2; fgl2 expression; fig; functions; gbm; gene; gsea; high; immune; immunity; important; infiltration; keap1; kras; level; lung; lung adenocarcinoma; lung cancer; macrophages; microenvironment; mrna; mutations; normal; pathway; patients; potential; progression; related; response; results; signaling; status; survival; t cells; timer; tissue; tumor; type
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143. cord-332650-05oz5zwz
     • author: Fiorelli, Silvia
     • title: Perspectives in surgical and anaesthetic management of lung cancer in the era of coronavirus disease 2019 (COVID-19)
     • date: 2020-08-26
     • words: 3277
     • flesch: 33
     • summary: Alternatively, some hospitals should be committed to treating COVID-19 patients exclusively (hub hospitals), whereas other medical centres can continue to treat ordinary non-infected cases (COVID-19-free spoke hospitals) Particulate respirators, designed to block 95-99% of aerosol particles and recommended during management of COVID-19 patients, should be routinely used during thoracic anaesthesia.
     • keywords: aerosol; airway; bronchoscopy; cancer; care; centre; clinical; component; coronavirus; covid-19; diagnostic; disease; early; elective; fig; follow; ggo; ggos; glass; health; high; hospital; infected; infection; life; lung; lung cancer; malignant; management; medical; need; non; order; outcomes; pandemic; patients; pet; precautions; probability; procedures; resection; respiratory; risk; solid; spread; staff; stage; surgery; surgical; therapeutic; thoracic; treatment; tube; use; volume
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144. cord-334528-xenq90xj
     • author: Chen, Hsing I
     • title: Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations
     • date: 2011-03-17
     • words: 5315
     • flesch: 29
     • summary: I. Light microscopy Ventilator-induced lung injury Cellular stress failure in ventilator-injured lungs Acute respiratory distress syndrome: a historical perspective The acute respiratory distress syndrome Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management Leukocyte elastase: physiological functions and role in acute lung injury Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit Chemokines in acute respiratory distress syndrome Transcriptional mechanisms of acute lung injury Alveolar epithelial fluid transport in acute lung injury: new insights Mechanisms of pulmonary edema clearance Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story Critical care in AJRCCM Alveolar recruitment in acute lung injury Prone position augments recruitment and prevents alveolar overinflation in acute lung injury Hypercapnic acidosis attenuates endotoxin-induced acute lung injury Protective effects of hypercapnic acidosis on ventilator-induced lung injury Permissive hypercapnia: role in protective lung ventilatory strategies Hypercapnia via reduced rate and tidal volume contributes to lipopolysaccharide-induced lung injury Permissive hypercapnia impairs pulmonary gas exchange in the acute respiratory distress syndrome Nonventilatory treatments for acute lung injury and ARDS Ventilatory management of acute lung injury and acute respiratory distress syndrome Acute respiratory distress syndrome: pharmacological treatment options in development Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome Inhaled nitric oxide therapy in adults Exercise training attenuates septic responses in conscious rats Vascular endothelial growth factor and related molecules in acute lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Insulin attenuates endotoxin-induced acute lung injury in conscious rats Comparison of propofol and midazolam for sedation in critically ill patients An update of its use in anaesthesia and conscious sedation The reduction of tumor necrosis factor-alpha release and tissue damage by pentobarbital in the experimental endotoxemia model N-acetylcysteine ameliorates lipopolysaccharide-induced organ damage in conscious rats Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study Antioxidant supplementation in sepsis and systemic inflammatory response syndrome N-acetylcysteine as the magic bullet: too good to be true Experimental studies and clinical investigations were supported in part by grants from the National Science Council. [77, 78] Intratracheal instillation of hydrochloric acid (HCI) or gastric particles has been employed as experimental model of acute lung injury (ALI).
     • keywords: acetate; acetylcysteine; acid; acute; acute lung; addition; air; ali; alveolar; ards; aspiration; associated; attenuates; causes; changes; clinical; conscious; cytokines; damage; disorders; distress; edema; effects; elastase; embolism; endotoxin; experimental; expression; factors; fat; fluid; heart; hemodynamic; hemorrhage; hypercalcemia; hypertension; inducible; inflammatory; injury; inos; intracranial; investigations; isolated; laboratory; lps; lung; lung injury; mechanisms; myristate; neurogenic; neutrophil; nitrate; nitric; oleic; organ; oxide; pathogenesis; patients; pentobarbital; phorbol; plasma; pressure; propofol; pulmonary; rats; release; reperfusion; respiratory; responses; results; risk; role; sepsis; severe; studies; study; surfactant; sympathetic; syndrome; synthase; systemic; weight
     • versions: original; plain text
145. cord-335382-fk4um9nw
     • author: Farver, Carol F.
     • title: Molecular Basis of Pulmonary Disease
     • date: 2012-08-10
     • words: 32359
     • flesch: 38
     • summary: In hyperoxia-induced cell death, hyperoxia may induce the expression of angiopoietin 2 (Ang2) in lung epithelial cells. Annual report to the nation on the status of cancer Pathology and Genetics of Tumours of the Lung, Pleura AJCC Cancer Staging Manual varying), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released Diagnosis and management of lung cancer executive summary: ACCP evidence-based clinical practice guidelines Genetics of preneoplasia: Lessons from lung cancer Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH Lung cancer preneoplasia Characterizing the cancer genome in lung adenocarcinoma Focus on lung cancer New molecularly targeted therapies for lung cancer High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints Genetic and molecular alterations Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma Hereditary cancers disclose a class of cancer genes Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers Molecular oncogenesis of lung cancer Molecular genetics of lung cancer The P16/cyclin D1/
     • keywords: aberrant; abnormal; abnormalities; abundant; acs; activation; activity; acute; addition; adjacent; advanced; agents; airways; allelic; alterations; alveolar; alveoli; amplification; analysis; antibodies; antigen; apoptosis; appearance; areas; asbestos; asthma; atypical; bacteria; basis; bilateral; blood; body; breath; bronchial; bronchiectasis; bronchitis; cancers; carcinoids; carcinoma; cases; categories; category; cause; cavitation; cavities; cell lung; cells; cellular; central; cftr; changes; characteristic; characterized; chest; chester; chromosome; chronic; chronic lung; cigarette; classification; clinical; clinical disease; combination; common; complex; component; congenital; consists; copd; cough; course; csf; css; current; cycle; cyclin; cystic; cysts; cytokines; dad; damage; death; defects; deficiency; deletions; dendritic; destruction; development; diagnosis; differences; differentiation; diffuse; disease; distal; dna; domain; dysplasia; dyspnea; early; effects; egfr; emphysema; endothelial; environmental; eosinophils; epigenetic; epithelial; epithelial cells; epithelioid; erdheim; events; evidence; examination; exposure; expression; factor; familial; family; features; fever; fibers; fibroblasts; fibrosis; figure; findings; form; formation; frequent; function; fungi; gene; genetic; grade; granulomas; gross; group; growth; high; higher; hilar; histiocytes; histiocytosis; histologic; history; hla; hosts; human; human disease; hyperplasia; hypertension; idiopathic; ifn; iii; imaging; immune; immunity; immunocompromised; important; incidence; increased; infections; infiltrates; inflammation; inflammatory; inflammatory cells; influenza; inhibitors; initial; injury; innate; interstitial; invasion; invasive; involved; involvement; kinase; known; langerhans; large; large cell; lcnecs; lead; lesions; like; likely; long; loss; lower; lung; lung cancer; lung disease; lung pathology; lung tumors; lymph; lymphocytes; macrophages; main; major; majority; malignant; material; matrix; mechanisms; mediators; membrane; mesenchymal; mesothelioma; metastasis; methylation; microscopic; mms; molecular; molecules; mucin; multiple; muscle; mutations; necrosis; necrotizing; neoplasms; neoplastic; neuroendocrine; neutrophils; new; nodules; non; normal; nsclc; number; obstructive; oncogenes; onset; organisms; organs; p16; p53; pah; pap; pathogenesis; pathogens; pathology; pathway; patients; pattern; peripheral; phase; phenotype; picture; plasma; plch; pleural; pneumocystis; pneumonia; population; positive; precursor; presence; present; presentation; primary; production; progression; proliferation; prominent; promoter; proteases; protein; proteinosis; pulmonary; pulmonary alveolar; pulmonary disease; pulmonary fibrosis; pulmonary pathology; rare; ras; recent; receptor; recurrent; regions; regulation; related; release; remodeling; represent; respiratory; response; responsible; result; review; role; sarcoidosis; sclcs; second; secondary; setting; severe; signaling; similar; situ; size; small; small cell; smokers; smoking; smooth; spaces; specific; spectrum; spp; sputum; sqcc; squamous; stage; states; structures; studies; study; suppressor; surface; surfactant; survival; symptoms; syndrome; systemic; telomerase; therapy; tissue; tnfa; tp53; transcription; treatment; tsgs; tuberculosis; tumor; tumours; type; tyrosine; underlying; united; upper; variable; variety; vascular; vessels; viral; viruses; wall; women; years
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146. cord-335597-anrzcsrt
     • author: None
     • title: 44. Jahrestagung der Österreichischen Gesellschaft für Pneumologie
     • date: 2020-10-26
     • words: 14654
     • flesch: 44
     • summary: Methods: We performed single cell RNA sequencing on pulmonary arteries isolated from donors and pulmonary hypertension patients. Arteries in pulmonary hypertension patients displayed altered composition of EC population characterized by the diminished presence of one cell cluster.
     • keywords: 2020; abstracts; activity; acute; age; ahi; airway; analysis; apnea; approach; arterial; arteries; artery; associated; association; asthma; background; bal; biomarkers; blood; bmi; bpa; cancer; cases; cell; centers; central; changes; children; chronic; cht; clinical; cohort; colonisation; complications; conclusions; control; copd; copd patients; coronavirus; cov-2; covid-19; criteria; crp; csa; cteph; current; data; days; der; development; die; difference; disease; dysfunction; dyspnea; early; effects; eine; elevated; endothelial; exacerbations; exercise; expression; face; factors; female; fev1; fibrinogen; fibrosis; fig; findings; follow; free; function; future; fvc; general; gold; groups; health; hemodynamics; high; higher; highest; hsp90; human; hypertension; icc; ici; ilc; immune; important; independent; index; infection; inflammation; inflammatory; inhalation; insulin; interventions; ipah; life; local; lower; lung; lymphocyte; male; malignant; management; mean; median; medication; methods; mice; mindfulness; mit; model; months; mortality; mpap; multivariate; n =; nach; need; neutrophil; nlr; non; normal; nsclc; number; obese; obesity; observed; obstructive; outcome; overall; p =; paecs; pain; pandemic; parameters; parsimonious; patients; pfs; physical; pirfenidone; pneumonectomy; population; positive; postoperative; potential; predictors; present; pressure; pretreatment; prevalence; prevention; primary; prognostic; pulmonary; quality; rate; regression; rehabilitation; resection; respiratory; response; results; retrospective; right; risk; role; sars; score; sdb; serum; severe; sex; significant; single; sleep; slope; specific; spt; ssc; status; strategies; studies; study; subjects; survival; symptoms; syndrome; systemic; term; testing; tests; therapy; time; tissue; tmem16a; total; transplantation; treatment; tumor; type; use; vascular; vats; ventricular; vmis; weeks; world; worse; wurde; years
     • versions: original; plain text
147. cord-336560-m5u6ryy9
     • author: Boudewijns, Robbert
     • title: STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters
     • date: 2020-07-02
     • words: 5039
     • flesch: 37
     • summary: Of note, these receptor knockouts did not affect ACE2 expression in hamster lungs (Fig. S9A ), while interferon-stimulated genes (ISG) 27 such as MX-2 (strongly induced by IFNα/STAT2 signaling) and IP-10 (induced by both type I and type II IFNs) showed a differential expression pattern when comparing the different genotypes, triggered by SARS-CoV-2 infection (Fig. S9B) . The lack of readily accessible serum markers or the absence of overt disease symptoms in hamsters prompted us to establish a non-invasive means to score for lung infection and SARS-CoV-2 induced lung disease by computed tomography (CT) as used in standard patient care to aid COVID-19 diagnosis with high sensitivity and monitor progression/recovery 7, 33, 35, 36 .
     • keywords: acute; airway; animals; antibody; blood; c57bl/6; cells; clinical; control; convalescent; coronavirus; cov-2; covid-19; culture; cytokine; damage; data; day; different; disease; expression; fig; fold; hamsters; high; human; ifnar1; il-6; il28r; immune; immunity; induced; infected; infection; inflammation; inflammatory; interferon; key; knockout; levels; line; loads; lung; means; medium; method; mice; micro; model; mouse; non; organs; p.i; passage; pathogenesis; pathology; patients; plasma; pneumonia; qpcr; quantification; replication; respiratory; response; rna; role; sars; score; serum; severe; signaling; stat2; statistical; strains; study; syndrome; syrian; tcid50; tissue; treatment; type; van; vero; vhh-72; viral; virus; volume
     • versions: original; plain text
148. cord-336782-0zkb39v1
     • author: Fraile Gutiérrez, V.
     • title: Narrative review of ultrasound in the management of the critically ill patient with SARS-CoV-2 infection (COVID-19): clinical applications in intensive care medicine
     • date: 2020-11-02
     • words: 6663
     • flesch: 39
     • summary: Recomendations of the Cardiological Intensive Care and CPR Working Group of the Spanish Society of Intensive Care and Coronary Units Point-of-care lung ultrasound in patients with COVID-19 -a narrative review Chinese Critical Care Ultrasound Study G. Findings of lung ultrasonography of novel corona virus pneumonia during the 2019-2020 epidemic COVID-19 outbreak: less stethoscope, more ultrasound Lung ultrasound and B-lines quantification inaccuracy: B sure to have the right solution Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents COVID-19 Lo que el técnico tiene que saber Products with emerging viral pathogens and human coronavirus claims for use against SARS-CoV-2 Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) Verification of Endotracheal Tube Placement The assessment of four different methods to verify tracheal tube placement in the critical care setting Comparison of three different methods to confirm tracheal tube placement in emergency intubation ) for confirming endotracheal tube placement during emergency intubation Confirmation of endotracheal tube placement after intubation using the ultrasound sliding lung sign BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill A bedside ultrasound sign ruling out pneumothorax in the critically ill. Lung sliding Thoracic ultrasonography: a narrative review Chest ultrasound in acute respiratory distress syndrome Global and regional diagnostic accuracy of lung ultrasound compared to CT in patients with acute respiratory distress syndrome Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol Six versus eight and twenty-eight scan sites for B-line assessment: differences in examination time and findings Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress* Diagnosis of pneumothorax by radiography and ultrasonography: a meta-analysis Pleural ultrasonography versus chest radiography for the diagnosis of pneumothorax: review of the literature and meta-analysis Thelung point: an ultrasound sign specific to pneumothorax Sonographic diagnosis of pneumothorax Focused abdominal sonogram for trauma: the learning curve of nonradiologist clinicians in detecting hemoperitoneum Pleural ultrasonography Whole Body Ultrasonography in the Critically Ill Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Tissue Plasminogen Activator (tPA) treatment for COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): a case series Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Real-time ultrasound-guided catheterisation of the internal jugular vein: a prospective comparison with the landmark technique in critical care patients Guidelines for performing ultrasound guided vascular cannulation: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists Guidelines on the use of ultrasound guidance for vascular access Anatomical variations in the internal jugular veins of cancer patients affecting central venous access.
     • keywords: acp; acute; air; airing; alterations; anatomical; appendix; applications; ards; areas; assessment; bedside; blood; blue; cardiac; cardiovascular; care; chest; clinical; coronavirus; cov-2; covid-19; damage; diagnosis; different; disease; distress; dsd; echocardiography; examination; failure; fig; findings; function; guidelines; heart; high; higher; ill; imaging; indicative; infection; information; intensive; international; intubation; left; level; lines; lung; lung ultrasound; main; management; modality; mortality; myocardial; myocarditis; ott; pandemic; patients; pattern; pleural; pneumonia; pneumothorax; point; position; presence; probe; progression; protocol; pulmonary; rate; regions; respiratory; right; risk; sars; score; severe; sign; size; sliding; society; specific; study; syndrome; systolic; thoracic; time; transducer; tube; ultrasonography; ultrasound; use; vascular; venous; ventilation; ventricular; vessel
     • versions: original; plain text
149. cord-337789-pabaoiqs
     • author: Oprinca, George-Călin
     • title: Postmortem examination of three SARS-CoV-2-positive autopsies including histopathologic and immunohistochemical analysis
     • date: 2020-08-27
     • words: 5012
     • flesch: 43
     • summary: The sectioned surface had small areas of a more intense reddish color between stretched areas of dark purple color. The gastric mucosa was hyperemic with small areas of diffuse hemorrhage.
     • keywords: acute; alveolar; architecture; areas; aspect; autopsy; blood; case; cells; changes; congestion; consistent; cov-2; covid-19; cytopathic; dark; death; diffuse; disease; effect; examination; fig; findings; focal; formation; giant; history; hospital; hyaline; hyperplasia; immunohistochemical; important; inclusions; infection; inflammatory; injury; intra; like; lung; lymphocytes; marked; membranes; microscopic; microthrombi; mild; moderate; necrosis; nucleus; parenchyma; pathological; patient; perivascular; pneumocytes; positive; presence; present; prominent; pulmonary; red; renal; response; right; sars; signs; small; specific; studies; table; tissue; type; vascular; vessels; viral; wall
     • versions: original; plain text
150. cord-338070-y8zi8iz9
     • author: Liu, Wei
     • title: Pharmacological inhibition of poly (ADP-ribose) polymerase by olaparib ameliorates influenza-virus-induced pneumonia in mice
     • date: 2020-08-31
     • words: 4129
     • flesch: 43
     • summary: Olaparib remarkably reduced IAV mRNA expression, myeloperoxidase (MPO) level, and inflammatory cell infiltration in IAV lungs. Moreover, olaparib significantly reduced the level of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-6, and IL-4 and increased IL-10 in IAV lungs.
     • keywords: abcam; abnormal; activation; acute; adp; analysis; animal; anti; antiviral; balf; cell; challenge; chemokine; content; control; cytokines; day; days; different; drug; effects; experimental; expression; fig; group; h1n1; human; iav; induced; infected; infection; inflammation; inflammatory; influenza; inhibition; injury; iκbα; levels; lps; lung; mechanisms; mice; model; mpo; murine; normal; olaparib; p65; parp-1; pneumonia; poly; polymerase; post; protein; ribose; role; samples; study; target; tissues; tnf; treatment; usa; virus; weight
     • versions: original; plain text
151. cord-341472-29opvzrj
     • author: Curley, Gerard F.
     • title: Future therapies for ARDS
     • date: 2014-12-04
     • words: 1550
     • flesch: 31
     • summary: Results from pre-clinical studies suggest that intra-tracheal KGF reduces lung injury induced by hyperoxia, ventilator-induced lung injury, and bacterial pneumonia. In pre-clinical studies, heparin has been found to reduce alveolar fibrin deposition and exert anti-inflammatory effects.
     • keywords: ace; acute; angiotensin; anti; ards; aspirin; cells; clinical; distress; effects; endothelial; enzyme; factor; inflammatory; injury; lung; mesenchymal; mortality; patients; phase; randomized; respiratory; risk; role; studies; study; syndrome; table; therapy; tnfr1; trial; ventilator
     • versions: original; plain text
152. cord-342150-dadc8whz
     • author: Lindahl, Sten G. E.
     • title: Using the prone position could help to combat the development of fast hypoxia in some patients with COVID‐19
     • date: 2020-06-17
     • words: 2002
     • flesch: 35
     • summary: An investigation was designed to challenge the hypothesis that NO plays an important role in the regulation of regional lung perfusion. In addition, the study also assessed regional lung perfusion in volunteers by single photon emission computed tomography before and after NOS inhibition.
     • keywords: acute; blood; development; distribution; dorsal; flow; fractal; function; gas; geometry; gravity; important; investigations; lung; matching; nos; oxygenation; patients; perfusion; position; prone; pulmonary; regional; regions; regulation; respiratory; responsible; structure; supine; vascular; ventilation; ventral; vessels
     • versions: original; plain text
153. cord-343842-2klytw6c
     • author: Takamura, Shiki
     • title: Persistence in Temporary Lung Niches: A Survival Strategy of Lung-Resident Memory CD8(+) T Cells
     • date: 2017-07-01
     • words: 10356
     • flesch: 31
     • summary: Crosspresenting CD103 + dendritic cells are protected from influenza virus infection T-cell memory and recall responses to respiratory virus infections Activation phenotype, rather than central-or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells Lung CD103 + dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells Long-term maintenance of virus-specific effector memory CD8 + T cells in the lung airways depends on proliferation Activated antigen-specific CD8 + T cells persist in the lungs following recovery from respiratory virus infections Programs for the persistence, vigilance and control of human CD8 + lungresident memory T cells Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells Optimal generation of tissue-resident but not circulating memory T cells during viral infection requires crosspriming by DNGR-1+ dendritic cells Tissue instruction for migration and retention of TRM cells Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1 Local antigen in nonlymphoid tissue promotes resident memory CD8 + T cell formation during viral infection Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8 + T cell responses Distinct dendritic cell subsets dictate the fate decision between effector and memory CD8(+) T cell differentiation by a CD24-dependent mechanism Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection Dynamics of blood-borne CD8 memory T cell migration in vivo The chemokine receptor CCR5 plays a key role in the early memory CD8 + T cell response to respiratory virus infections Cutting edge: antigen is not required for the activation and maintenance of virus-specific memory CD8 + T cells in the lung airways Inflammatory chemokine receptors regulate CD8(+) T cell contraction and memory generation following infection Immunity to respiratory viruses Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration CD4 + T cell help guides formation of CD103+ lung-resident memory CD8 + T cells during influenza viral infection The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics Chemokine gene expression in lung CD8 T cells correlates with protective immunity in mice immunized intra-nasally with Adenovirus-85A CXCR6 is a marker for protective antigen-specific cells in the lungs after intranasal immunization against Mycobacterium tuberculosis Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes Prolonged antigen presentation by immune complexbinding dendritic cells programs the proliferative capacity of memory CD8 T cells Neutrophil trails guide influenza-specific CD8(+) T cells in the airways CXCL10/ CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T cell retention Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation T-box transcription factors combine with the cytokines TGF-beta and IL-15 to control tissue-resident memory T cell fate Hidden memories: frontline memory T cells and early pathogen interception Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1 Cutting edge: contribution of lung-resident T cell proliferation to the overall magnitude of the antigen-specific CD8 T cell response in the lungs following murine influenza virus infection Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs IL-15 transpresentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2 Airway-resident memory CD8 T cells provide antigenspecific protection against respiratory virus challenge through rapid IFN-gamma production Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4 Unique type It has long been believed that lung CD8 + T RM cells are maintained in the ectopic lymphoid tissues developed in response to respiratory virus infections, such as inducible bronchus-associated lymphoid tissues (iBALT)
     • keywords: activation; active; acute; airways; alpha; antigen; basal; beta; blood; case; ccr5; cd103; cd4; cd69; cd8; cd8 t; cells; chemokine; cognate; collagen; cxcr3; dcs; dendritic; differentiation; distinct; effector; effector cd8; effector cells; epithelial; establishment; expression; fact; factors; formation; generation; il-15; immunity; independent; infected; infection; inflammation; inflammatory; influenza; integrin; interstitium; levels; local; long; lung; lung airways; lung cd8; maintenance; memory; memory cd8; memory t; migration; mln; niches; nonlymphoid; numbers; parenchyma; peripheral; population; presentation; protection; ramds; recent; receptor; recruitment; resident; residual; respiratory; response; retention; rm cells; role; s1p; signaling; signals; site; skin; specific; specific cd8; subsets; t cells; t em; t rm; terminal; tgf; tissue; type; viral; virus; virus infection; vla-1
     • versions: original; plain text
154. cord-344206-53g7yjf9
     • author: Ray, Archita
     • title: A looming role of mitochondrial calcium in dictating the lung epithelial integrity and pathophysiology of lung diseases
     • date: 2020-09-21
     • words: 2176
     • flesch: 10
     • summary: key: cord-344206-53g7yjf9 authors: Ray, Archita; Jaiswal, Ashish; Dutta, Joytri; Singh, Sabita; Mabalirajan, Ulaganathan title: A looming role of mitochondrial calcium in dictating the lung epithelial integrity and pathophysiology of lung diseases date: 2020-09-21 journal: Mitochondrion DOI: 10.1016/j.mito.2020.09.004 sha: doc_id: 344206 cord_uid: 53g7yjf9 With the increasing appreciation of mitochondria in modulating cellular homeostasis, various disease biology researchers have started exploring the detailed role of mitochondria in multiple diseases beyond neuronal and muscular diseases. Thus, the regulation of mitochondrial calcium in lung epithelia seems to be critical in lung homeostasis and could be decisive in the pathogenesis of various lung diseases.
     • keywords: acute; aging; airway; alveolar; apoptosis; asthma; beating; biology; calcium; cancer; cells; channel; chronic; ciliary; copd; cystic; disease; dysfunction; epithelial; fibrosis; functions; health; homeostasis; human; inflammation; injury; intracellular; lung; mcu; metabolic; mitochondrial; muscle; obstructive; pathogenesis; pulmonary; regulation; related; remodeling; role; severe; smoke; smooth; uniporter; uptake
     • versions: original; plain text
155. cord-348672-e34103b1
     • author: Zhang, Jiaqi
     • title: Postoperative Short-term Outcomes Between Sublobar Resection and Lobectomy in Patients with Lung Adenocarcinoma
     • date: 2020-10-01
     • words: 3251
     • flesch: 37
     • summary: Considering that adenocarcinoma dominated a great part in lung cancer, the purpose of this study was to retrospectively analyze the short-term outcomes of lung adenocarcinoma patients who underwent different lung resections. Early diagnosis and early treatment significantly benefit the overall survival of lung cancer patients.
     • keywords: adenocarcinoma; adl; albumin; analysis; cancer; chest; clinical; coefficient; complications; correlation; data; differences; different; dimer; drainage; duration; early; function; hospital; length; level; lobectomy; lung; lymph; margin; nlr; number; outcomes; p=0.000; patients; perioperative; postoperative; psm; resection; results; scale; segmentectomy; significant; similar; stage; staging; study; sublobar; sublobar resection; surgery; surgical; survival; term; test; total
     • versions: original; plain text
156. cord-349226-xzlc1pni
     • author: Khatiwada, Saroj
     • title: Lung microbiome and coronavirus disease 2019 (COVID-19): possible link and implications
     • date: 2020-08-05
     • words: 4317
     • flesch: 31
     • summary: The COVID-19 disease begins with the invasion of lungs by SARS-CoV-2 virus, and the major complications that develop subsequently are related to lung infection and immune response generation, therefore, lung microbiome might play an important role from initiation to the progression of this disease [16] . In lung diseases, these factors can change, and therefore overgrowth of one species with reduction of microbial diversity occurs (shown in figure 1 )
     • keywords: abundance; acute; ards; asthma; bacterial; cells; clinical; common; complications; composition; coronavirus; cov-2; covid-19; covid-19 disease; current; date; death; development; disease; diverse; diversity; environment; evidence; exposure; factor; future; growth; gut; healthy; host; human; immune; immunity; increase; infection; inflammation; influenza; injury; innate; interferon; lower; lung; lung microbiome; microbes; microbial; microbiome; microorganisms; pathogens; patients; pneumonia; potential; protein; pulmonary; relationship; respiratory; response; review; rhinovirus; role; sars; severe; severity; specific; streptococcus; studies; study; surface; syndrome; tract; viral
     • versions: original; plain text
157. cord-352532-xqphom6x
     • author: Papanikolaou, Ilias C
     • title: 1 Tropical Lung Diseases
     • date: 2013-12-31
     • words: 3342
     • flesch: 38
     • summary: In a typical tropical clinic, 20-40% of outpatients have respiratory complaints, and 20-30% of inpatients have lung disease (Table 1-1) Many tropical patients suffer from lung diseases that are found worldwide, e.g. asthma, bronchiectasis, chronic obstructive lung disease, HIV infection-related lung disease, and lung cancer.
     • keywords: acute; asthma; available; bacterial; blood; cases; cause; chest; children; chronic; clinical; common; community; copd; cough; countries; days; diagnosis; disease; dyspnea; e.g.; effusion; elderly; eosinophilia; examination; fever; fig; fluid; health; hemoptysis; important; individuals; infection; inhalation; leptospirosis; low; lung; lung disease; malaise; melioidosis; obstructive; oral; pain; parasitic; patients; pleural; pneumococcal; pneumonia; pulmonary; ray; respiratory; severe; skin; sputum; symptoms; syndrome; table; treatment; tropical; tropics; tuberculosis; typical; upper; weeks; wheezing; worldwide
     • versions: original; plain text
158. cord-353013-7cx0gnum
     • author: DENG, Pengbo
     • title: Bronchial Fistula: Rare Complication of Treatment with Anlotinib
     • date: 2020-10-20
     • words: 4364
     • flesch: 51
     • summary: We aim to report 3 cases of rare complication of anlotinib-bronchial fistula (BF) during the treatment of lung cancer patients and summarize the possible causes. BPF is more common in lung cancer patients after surgery, directly caused by lung cancer invasion is rarely reported which usually combined with infection [15] .
     • keywords: advanced; angiogenesis; anlotinib; anti; attention; bevacizumab; bpcf; bpf; bronchial; bronchus; cancer; case; causes; cavitation; cavity; cell; cell lung; characteristics; chemotherapy; clinical; common; drainage; etbf; factor; fig; fistula; following; formation; growth; incidence; infection; invasion; left; line; lung; lung cancer; months; non; nsclc; patients; phase; rare; right; risk; search; small; sputum; squamous; survival; symptoms; treatment; trial; trt; tumor; upper; use; wall
     • versions: original; plain text
159. cord-355122-x3v80bdp
     • author: Desterke, Christophe
     • title: PPARγ cistrome repression during activation of lung monocyte-macrophages in severe COVID-19
     • date: 2020-09-25
     • words: 7901
     • flesch: 31
     • summary: Overall, these results demonstrate for the first time, the involvement of the PPARγ complex in severe COVID-19 lung disease and suggest strongly its role in the major monocyte / macrophage-mediated inflammatory storm. We identified a correlation with the disease severity and the reduced expression of several members of the PPARγ complex such as EP300, RXRA, RARA, SUMO1, NR3C1, CCDC88A. CHIP-seq analyses confirmed repression of the PPARγ-RXRA-NR3C1 cistrome in COVID-19 lung samples.
     • keywords: activation; adaptive; alpha; analysis; associated; binding; biopsies; bronchoalveolar; cases; cd14; cd16; cell; checkpoints; chip; cistrome; complex; coronavirus; covid-19; covid-19 lung; covid-19 patients; covid-19 samples; covid19; cytokine; data; database; dependent; diabetes; different; disease; donors; enrichment; et al; evidence; expression; factors; figure; fluid; gamma; gene; healthy; hla; host; human; il-6; immune; immune response; increase; induction; infection; infiltration; inflammation; inflammatory; innate; interferon; lavage; level; like; lung; lung samples; macrophages; major; metabolism; molecules; monocytes; myeloid; nes; network; nr3c1; pathway; patients; peroxisome; population; pparγ; program; proliferator; promoter; protein; receptor; respiratory; response; results; rna; role; rxra; samples; sars; seq; set; severe; severe covid-19; severity; signaling; signature; single; storm; study; sumo1; supplemental; supplemental figure; syndrome; table; thp-1; tissue; transcription; transcriptome; type; upregulated; value<0.001; virus
     • versions: original; plain text
160. cord-356174-40k6m7l0
     • author: Ducloyer, Mathilde
     • title: Complete post-mortem data in a fatal case of COVID-19: clinical, radiological and pathological correlations
     • date: 2020-08-06
     • words: 2880
     • flesch: 42
     • summary: Only viral cultures from post-mortem samples would reliably demonstrate viral survival in the deceased. Post-mortem virology studies detected the presence of SARS-CoV-2 (B.1 lineage) in the nasopharynx, plasma, lung biopsies, pleural effusion and faeces confirming the persistence of viral ribonucleic acid 48 h after death.
     • keywords: acute; alveolar; areas; autopsy; bilateral; blood; body; cases; cells; changes; china; clinical; complete; coronavirus; covid-19; damage; data; death; deceased; diffuse; disease; effusion; examination; findings; fluid; forensic; heart; imaging; immune; infection; lungs; microscopic; moderate; mortem; nasopharyngeal; normal; novel; pathogenesis; pathological; pathology; patients; plasma; pleural; pmct; pneumonia; post; postmortem; present; pulmonary; respiratory; response; room; samples; sars; severe; study; swab; syndrome; viral; virology
     • versions: original; plain text