item: #1 of 68
          id: cord-000884-zq8kqf6h
      author: Shen, Hsin-Hui
       title: Reconstitution of Membrane Proteins into Model Membranes: Seeking Better Ways to Retain Protein Activities
        date: 2013-01-14
       words: 6869
      flesch: 36
     summary: This review will discuss the reconstitution of membrane protein activities in four different types of model membrane—monolayers, supported lipid bilayers, liposomes and nanodiscs, comparing their advantages in membrane protein reconstitution. It is essential to find better solutions for retaining membrane protein activities for measurement and characterization in vitro.
    keywords: activities; activity; adsorption; air; approach; assembly; atpase; atpase activity; bilayer; binding; cell; channel; cholera; complex; conditions; curvature; cushions; cyp3a4; cytochrome; detailed; detergent; different; effect; environment; enzyme; example; figure; formation; functional; fusion; ganglioside; glycoprotein; high; human; hydrolysis; hydrophilic; incorporated; integral; interactions; interface; ionic; kinase; langmuir; lipid; lipid bilayer; low; male; maltose; membrane; membrane proteins; method; model; model membrane; molecules; monolayers; nanodiscs; native; nuclear; p450; patch; peripheral; phospholipid; planar; polymer; possible; presence; properties; proteins; proteoliposomes; receptors; reconstituted; reconstitution; rhodopsin; seca; secyeg; self; single; structure; studies; study; substrate; supported; surface; system; technology; toxin; transporter; types; vesicles; water; water interface
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        item: #2 of 68
          id: cord-001835-0s7ok4uw
      author: None
       title: Abstracts of the 29th Annual Symposium of The Protein Society
        date: 2015-10-01
       words: 138771
      flesch: 38
     summary: In conclusion, the analysis of hydropathic environments strongly suggests that the orientation of a residue in a three-dimensional structure is a direct consequence of its hydropathic environment, which leads us to propose a new paradigm, interaction homology, as a key factor in protein structure. In computer simulation modeling of protein structure in a solvent medium, explicit, implicit, effectivemedium, approaches are often adopted to incorporate the effects of solvation.
    keywords: 1,2; aat; absence; abstract; abundant; accelerated; access; accessible; account; accumulation; accuracy; accurate; acid; acid sequence; acidic; activation; active; active site; activities; activity; acts; adaptation; adaptor protein; addition; adhesion; adjacent; advanced; advantages; affimers; affinities; affinity; afps; agents; aggregates; agreement; aid; aif; aim; aims; aldehyde; algorithm; alignments; allosteric; alpha; altered; alternative; alzheimer; amide; amino; amino acid; amounts; amyloid; amyloidogenic; amyloidosis; analysis; analytical; ancestral; ancestral protein; angle; annotation; antibiotics; antibodies; antibody; antigen; antimicrobial; apoptosis; apparent; applications; applied; approach; aqueous; architecture; area; aromatic; arrangement; artificial; artificial protein; asn; aspects; assay; assembly; associated; atomic; atoms; atp; attempts; attractive; available; b domain; b2gpi; bacillus; backbone; background; bacterial; barrel; barrel proteins; barrier; basis; behavior; best; beta; better; biased; bilayer; binders; binding; biochemical; biochemistry; bioinformatics; biological; biology; biomedical; biomolecular; biopanning; biophysical; biosynthesis; biotechnology; bis; blocks; blood; bonds; bovine; box; bp1; bphp1; bpti; brain; breast; bret; bridges; broad; brucei; bsfnr; buffer; building; bundle; ca21; cabs; calcium; calculated; calculations; california; calorimetry; cancer; candidate; canonical; capable; capacity; capture; carbohydrate; carbon; cases; caspase; catalysis; catalytic; catalytic activity; catalytic domain; catalyze; cationic protein; cause; cavity; cbs; cdc42; cdna; cell; cell membrane; cellular; cellular proteins; center; central; centre; cerevisiae; certain; chain; challenges; challenging; changes; channel; chaperones; characteristics; characterization; characterized; charged; chemical; chemistry; chilensis; chimeric; chip; chitinase; cholesterol; choline; chromatin; chromatography; chromophore; circular; cis; class; classical; cleavage; clinical; clock; close; clustering; clusters; cml14; coarse; cofactor; coil; cold; coli; collagen; column; combination; combined; common; communication; comparable; comparison; complementary; complete; complex formation; complex structure; complexes; components; composition; compounds; comprehensive; computational; computational protein; computer; concentrated; concentration; concept; conclusion; conditions; conformational; conformational changes; conjugates; consensus; consequence; conservation; conserved; considerable; consistent; constants; construct; contacts; context; continuous; contrast; contribution; control; conventional; conversion; cooperative; cooperativity; coordination; copper; core; correct; correlated; correlation; corresponding; cortisol; cost; coupling; covalent; critical; cross; crowding; crucial; crystal; crystal structure; crystallization; crystallography; csic; culture; current; cw_7; cycle; cys; cysteine; cytochrome; cytoplasmic; cytosol; cytotoxicity; d2r; damage; dark; data; database; dataset; david; death; decrease; degree; degrons; dehydrogenase; deletion; delivery; denaturation; density; department; dependent; dept; description; designing; designs; detailed; details; detection; detergent; determinants; determination; determined; developed; development; dhrs7; diabetes; diagnosis; diameter; dichroism; diego; differences; different; different protein; differential; difficult; diffusion; dimensional; dimensional structure; dimer; dimeric; dimerization; direct; discovery; disease; disordered; disordered proteins; display; dissociation; distance; distant; distinct; distribution; disulfide; diverse; dj-1; dna; docking; domain; domain interactions; domain structure; dominant; double; downstream; drug; dxt; dye; dynamical; e.coli; e.g.; early; effect; effective; efficacy; efficiency; efforts; egfr; eif4e; electron; electrophoresis; electrostatic; elements; elisa; emission; enable; encoding; endogenous; energy; enhanced; ensemble; enthalpy; entire; entropy; entry; envelope protein; environment; enzymatic; enzyme; enzyme activity; epitope; equilibrium; erf1; erk; escherichia; essential; essential protein; etc; eukaryotic; events; evidence; evolutionary; evolved; example; excellent; exchange; exclusion; exhibit; experiments; explicit; expressed; expression; extant; extended; extensive; extraction; factors; fad; family; far; fast; fatty; fbp17; features; fermentation; fibers; fibrillar; fibrillation; fibrils; fibrin; fibrinogen; fiia; final; findings; fish; fitness; fkbp12; flexibility; flexible; flow; fluctuations; fluorescence; fluorescent protein; focus; following; food; for20; force; formation; forms; foundation; foxp1; fraction; fragments; free; fret; ftir; functional; fundamental; fungal; fungi; fusion; fusion proteins; future; fxiiia; g protein; g6pd; gag; gain; gel; gene; general; generated; generation; genetic; genome; genomic; geometries; geometry; gfp; global; globular; globular protein; glucose; glycoprotein; goal; golgi; good; gp120; gp74; gpcr; gracilaria; graduate; grant; grd; great; greater; green; groel; group; growth; gtp; hairpin; half; hand; hcv; health; heat; helical; helices; helix; help; heme; hfen1; hiapp; hiat; high; high affinity; higher; highest; highly; hinge; histidine; histone; hits; hiv; hnh; hnp; homeostasis; homologous; homologous proteins; homology; hormone; host; hplc; hsp70; htra3; human; human protein; huntingtin; hydrogen; hydrolase; hydrolysis; hydropathic; hydrophobic; hydrophobicity; hydroxylation; hypothesis; hypoxia; identical; identification; igg; iii; imaging; immobilized; immune; impact; important; improved; inactive; incorporation; increase; incubation; individual; induced; industrial; infection; inflammatory; influence; influenza; inhibited; inhibition; inhibitors; initial; initiation; initio; insertion; inside; insights; institute; integral; intensity; interacting; interactome; interest; interfaces; intermediates; intermolecular; internal; intracellular; intrinsic; introduction; investigation; involved; isobutene; isoforms; isolated; isolation; isothermal; itc; iterative; kcat; kcne3; kcnq1; kda; key; kinetic; knowledge; known; kunitz; kurozu; laboratory; laccases; lack; lacking; larfh; large; leading; leads; ledgf; length; length protein; leukocyte; level; libraries; library; life; ligand; ligand binding; light; like; like protein; likely; limitations; limited; linear; lines; linker; linking; lipase; lipid; liposomes; lippi12; literature; little; liver proteins; living; local; localization; long; longer; loop; loss; low; lower; lupin; lysine; lysozyme; machinery; macromolecular; magnetic; major; majority; mammalian; manner; mapping; mass; materials; matrix; means; measurements; mechanism; mechanistic; medicine; medium; members; membrane protein; membranes; metabolism; metal; method; methodology; methyl; mice; micelles; microorganisms; microscopy; microtubule; migration; milk; minimal; minor; misfolding; mitochondrial; mixing; mobile; mobility; model; model protein; modeling; modern; modification; modified; modular; modulate; modulation; modulators; modules; moiety; molecular; molecular dynamics; molecular function; molecular interactions; molecular mechanism; molecules; molten; monitoring; monoclonal; monomer; monomeric; moonlighting proteins; motif; motions; mouse; mrna; multiple; muscle; mutagenesis; mutant; mutated; mutations; myoglobin; nad1; nadph; nano; nanodiscs; nanoparticles; nascent; national; native; native protein; native structure; natural; natural protein; nature; near; necessary; need; negative; network; neurodegenerative; neuronal; neurons; neutral; new; new protein; nmr; nmr structure; non; novel; novo; npc; ns5a; nsh2; nth1; nuclear; nucleotide; nucleus; number; numerous; observations; observed; occurring; odc; oligomerization; oligomers; oligonucleotide; ongoing; open; optimization; order; organic; organisms; organization; orientation; origin; ornithine; outer; overall; overexpression; oxidation; oxidative; oxidized; oxygen; p10; p110a; p2x7r; p75; p85; page; pain; parallel; parameters; parasite; parkinson; partial; particles; particular; partitioning; partners; past; pathogenesis; pathogenic; pathological; pathways; patients; patterns; pbs; pcr; pdb; pdc; people; peptide; peptidoglycan; performance; permeability; pfxiii; pgds; pharmaceutical; phase; phenotype; phenylalanine; phosphate; phosphorylation; physicochemical; physics; physiological; place; plants; plasma; plasmid; plasmon; platform; platinum; pocket; point; polar; polii; polymerase; polymerization; polypeptide; polyq; polyubiquitin; pool; poorly; pore; porphyrin; position; positive; possibility; possible; possible protein; post; potency; potential; powerful; ppis; precise; prediction; preliminary; prepared; presence; present; pressure; previous; primary; prior; prmt1; probe; problem; procedure; process; processes; processing; products; profile; program; progress; project; proline; promising; promoter; propensity; properties; proposed; protease; protective; protein; protein activation; protein activity; protein aggregation; protein arginine; protein assembly; protein association; protein backbone; protein capsules; protein chain; protein chemistry; protein coatings; protein complex; protein concentration; protein conformation; protein core; protein crystallization; protein crystallography; protein data; protein degradation; protein design; protein domain; protein dynamics; protein engineering; protein environment; protein evolution; protein expression; protein families; protein folding; protein fragments; protein function; protein helices; protein inhibitor; protein interactions; protein interface; protein kinases; protein ligation; protein mass; protein modification; protein molecules; protein network; protein pairs; protein partners; protein phosphatase; protein plasticity; protein production; protein quality; protein recognition; protein responsible; protein scaffolds; protein science; protein sequences; protein specific; protein stability; protein structure; protein substrates; protein surface; protein switches; protein synthesis; protein systems; protein turnover; protein tyrosine; protein variants; proteins protein; proteolysis; proteome; proteomic; protocol; proton; provide; proximal; proximity; psgk; psm; ptks; ptth; pure; purification; purified; purpose; putative; quantitative; quantum; quaternary; quercetin; rad18; random; range; rapid; ray; rdrp; reaction; reactive; recent; receptor; receptor protein; recognition; recombinant protein; recruitment; redox; reduced; reducing; reductase; refolding; region; regulated; regulation; regulatory; related; relationship; relative; relaxation; release; relevance; relevant; remarkable; repair; repeat proteins; repeats; replacement; replication; reported; reporter protein; research; residues; resistance; resonance; respect; respiratory; response; responsible; restricted; results; retention; retinal; reverse; reversible; rha; rhodopsin; ribosome; rich; rigid; rna; rnase; robust; role; rosetta; rounds; rpfnr; salt; samples; san; sardine; saxs; scaffold; scale; scanning; scattering; scfv; school; science; scoring; screening; sds; searches; secondary; secondary structure; sedimentation; seeds; selected; selection; selective; selectivity; self; sensitive; sensitivity; sensor; sensor proteins; sequence; sequencing; sequential; series; serine; serpin; server; set; sets; severe; sg proteins; sh2; sh3; shape; sheet; shift; shock protein; short; shows; sigma; signal; signaling; significant; silico; silkworm; similar; similarities; similarity; simple; simulations; single; single protein; site; size; slc; slow; small; small protein; smash; sn-38; snare; snare proteins; sod1; sodium; software; solid; solubility; soluble; solution; solution structure; solvation; solvent; sortase; source; sp1; space; spatial; species; specific; specificity; spectra; spectrometry; spectroscopy; spectrum; spr; src; ssdna; stabilities; stability; stabilized; stable; stable protein; starch; starting; state; statistical; step; stm; strains; strand; strategies; strategy; strength; stress; strong; structural; structural analysis; structural biology; structural changes; structural characterization; structural information; structural studies; structure prediction; studies; study; subdomain; subsequent; subset; substrate; subunit; successful; sufficient; suitable; superfamily; support; surface; survival; swapping; symmetric; synthase; synthesis; synthetic; synuclein; system; tags; tandem; target; target protein; targeted; targeting; tau protein; techniques; technology; temperature; template; tendency; terminal; terminal domain; termini; terminus; terms; tertiary; tertiary structure; tested; theoretical; theory; therapeutic; thermal; thermodynamic; thrombin; throughput; tif2; time; tims; tissues; titration; tof; tool; topology; torso; total; toxic; toxicity; toxins; traditional; trafficking; transcription; transduction; transfer; transformation; transient; transition; translational; translocation; transmembrane; transmembrane protein; transport; treatment; triggers; trimer; triple; trp; trypsin; tryptophan; ttr; tubulin; tumor; turn; type protein; types; typical; ubiquitin; ubiquitous; uch; ultracentrifugation; umpase; unbound; unclear; underlying; understanding; understood; unfolded; unfolding; unique; universidad; university; unknown; unstructured; uptake; urea; use; useful; uses; vaccine; valuable; values; variability; variable; variants; variation; variety; vector; venom; view; viral; virus; vitro; vivo; voltage; volume; vpg; wall; water; weak; weight; western; wh1; wide; wild; work; world; years; yeast; yield; zearalenone; zinc; zn21; ımica
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        item: #3 of 68
          id: cord-004534-jqm1hxps
      author: None
       title: Abstract
        date: 2009-06-09
       words: 139178
      flesch: 39
     summary: This simple model illustrates how differential detergent selectivity for faces and strong constraints coming from purely environmental features could influence transmembrane helix packing, membrane protein structure and assembly. Imaging of mobile stable lipid rafts in the live cell plasma membrane M. Brameshuber 1 , J. Weghuber 1 , V. Ruprecht 1 , H. Stockinger 2 , G. J. Schuetz 1 1 Johannes Kepler University Linz, Austria, 2 Medical University of Vienna, Austria The organization of the cellular plasma membrane at a nanoscopic length scale is believed to affect the association of distinct sets of membrane proteins for the regulation of multiple signaling pathways.
    keywords: a. m.; a30p; aba; able; absence; absorption; academy; acceleration; acceptor; accessible; account; accumulation; accuracy; acid; acidic; acquisition; actin; activation; active; activities; activity; acyl; addition; address; adhesion; adp; adult; advanced; advantage; affected; affinity; afm; agents; aggregates; aggregation; agreement; aim; albumin; algorithm; alp14; alpha; altered; alternative; alzheimer; amb; amino; amounts; amplitude; amyloid; amyloidogenic; analogues; analysis; analytical; angle; animals; anionic; anisotropy; antenna; antibiotics; antibody; anticancer; antigen; antimicrobial; apoptosis; apoptotic; apparent; applications; applied; approach; appropriate; aqueous; architecture; area; aromatic; arrays; artificial; aspects; assay; assemblies; assembly; associated; atomic; atomic force; atomistic; atoms; atp; atpase; attached; attachment; attention; attractive; austria; available; average; axis; azurin; backbone; background; bacterial; balance; bands; barcelona; barrier; base; basis; bax; beads; beam; behavior; belgium; berlin; best; beta; better; bianchini; bilayer; binary; binding; biochemical; biochemistry; biofisica; biological; biological membranes; biology; biomedical; biomembrane; biomolecular; biophysics; biosensors; biotechnology; biotin; blood; bodipy; body; bologna; bond; bovine; brain; breast; bridge; brightness; broad; brownian; bsa; budding; buffer; build; caf1; cagliari; calcium; calculated; calculations; calorimetry; cancer; cancer cells; candidate; capable; capsid; carbohydrate; carbon; cardiac; cardiomyocytes; carlo; carriers; case; catalysis; catalytic; cationic; causes; cavities; cea; cell; cell biology; cell cycle; cell imaging; cell membrane; cell surface; cellular; center; central; centre; certain; chain; changes; changing; channel; chaperone; characteristic; characterization; characterized; charge; chemical; chemistry; chip; chitosan; chloride; chlorophyll; chloroplast; cholesterol; chromatin; chromophore; circular; cis; clamp; class; classical; clavulanic; clc; cleavage; clinical; close; clustering; clusters; cnr; cnrs; coarse; coated; coefficient; coil; cold; coli; collagen; collagenase; collective; college; colloids; color; combination; combined; common; compact; comparable; comparison; complementary; complete; complex; complexes; components; composition; compounds; computational; computer; concentration; concept; conclusion; condensation; conditions; conductance; configuration; confined; confinement; confocal; confocal microscopy; conformational; conformational changes; consequence; conserved; considerable; consistent; constant; constructs; contact; content; continuous; contraction; contrast; contribute; contribution; control; controlling; conventional; conversion; coordination; core; correlation; corresponding; counterions; counting; coupling; covalent; cp29; cpt; critical; cross; crucial; crystal; crystalline; crystallography; culture; current; curvature; curves; cycle; cyclic; cysteine; cytochrome; cytometry; cytoplasm; cytoskeleton; cytosolic; damage; dark; data; day; days; death; decay; decrease; decreasing; deeper; defensins; degradation; degree; delivery; demonstrated; denaturation; denmark; densities; density; department; dependent; depletion; deposition; dept; derivatives; description; design; destabilization; detailed; details; detection; detergent; determination; determined; developed; development; device; diabetes; diameter; diaspro; dichroism; differences; different; different lipid; different membrane; different molecular; different proteins; differential; differentiation; diffraction; diffusion; dimensional; dimer; dimerization; dipartimento; dipole; direct; direction; discovery; disease; disordered; displacement; display; dissociation; distance; distinct; distribution; diverse; division; dmpc; dna; dna complexes; dna molecule; docking; domain; donor; dopc; double; dppc; drug; dsc; duplex; duration; dyes; dynamical; dynamics; dynamics simulations; e.g.; early; ecs; effect; effective; efficacy; efficiency; ejection; elastic; elc; electric; electrochemical; electrode; electron; electron microscopy; electrophoresis; electrophysiological; electrostatic; elements; elongation; emission; emodin; endogenous; energies; energy; energy transfer; engineered; engineering; enhancement; enriched; ensemble; enthalpy; entropy; entry; environment; enzymatic; enzyme; epr; equilibrium; erythrocytes; esr; essential; estimate; estimation; etbr; ethanol; eukaryotic; evanescent; events; evidence; example; excess; exchange; excitation; excited; exhibits; existence; expansion; experimental data; experimental results; experiments; explanation; exponential; exposure; expression; extended; extension; extensive; extent; external; extracts; extrusion; factors; faculty; failure; family; far; fast; faster; fatty; fccs; fcs; features; fibers; fibres; fibrillar; fibrils; field; filaments; film; filter; findings; fisica; fit; flexibility; flim; flow; fluctuations; fluid; fluidity; fluorescence; fluorescence correlation; fluorescence emission; fluorescence experiments; fluorescence intensity; fluorescence lifetime; fluorescence microscopy; fluorescence properties; fluorescence techniques; fluorescent protein; fluorophores; flux; fluxes; focus; focused; following; force; force microscopy; force spectroscopy; formation; forms; forward; fourier; fps; fragments; frame; france; frap; free; free energy; frequencies; frequency; fret; ftir; function; functionalized; functioning; fundamental; fungal; future; g protein; gag; gain; gap; gating; gel; gels; gene; general; generation; genetic; genome; genomic; genova; georgia; germany; gfp; giant; glucose; glutamate; glycation; goal; gold; good; gram; great; greater; green; grenoble; group; growth; guvs; göttingen; hairpin; half; hand; harmonic; head; heat; heating; heavy; heidelberg; helical; helices; helix; help; heme; hemoglobin; heparin; hepatitis; heterogeneity; high; higher; histone; hiv-1; hmga2; hmgb1; homologous; hormone; host; hours; hp1; hsa; hsp22; human; hungary; hybrid; hydrated; hydration; hydrodynamic; hydrogels; hydrogen; hydrolysis; hydrophobic; hyp; hypothesis; iapp; ideal; identical; identification; iii; iit; illumination; image; imaging; imaging microscopy; immobilization; immobilized; immune; impact; important; important role; inclusions; incorporated; incorporation; increase; incubation; individual; induced; induction; infection; influence; infrared; inhibition; inhibitors; initial; initiation; inner; inorganic; insertion; inside; insight; institute; instrument; insulin; intact; integral; integrin; integrity; intensity; interaction; interest; interesting; interface; interference; interior; intermediate; intermolecular; internal; interplay; intracellular; intrinsic; investigation; involved; ionic; irradiation; islet; isoforms; isolated; isothermal; isotropic; istituto; italian; italy; itc; japan; johannes; jump; kcl; kcsa; kda; key; kinase; kind; kinetics; knowledge; known; ktp; label; labeling; laboratory; lack; lambs; lapse; large; laser; lateral; law; ldl; leading; leaflet; length; level; lfa-1; lifetime; ligand; ligand binding; light; light scattering; like; like protein; likely; limited; limiting; linear; linked; linking; linz; lipid; lipid bilayer; lipid membranes; lipid vesicles; liposomes; liquid; literature; little; live cells; living; living cells; load; local; localization; lodz; london; long; longer; loop; loss; low; lower; lps; luciferase; lung; luv; lysine; lysozyme; macromolecules; macroscopic; magnetic; magnitude; major; mammalian; manner; marker; mass; material; mathematical; matrix; matter; maturation; maximum; means; measured; measurements; mechanical; mechanism; medical; medicine; medium; melting; membrane; membrane fluorescence; membrane fusion; membrane interaction; membrane microdomains; membrane potential; membrane properties; membrane protein; membrane structure; membrane surface; membrane system; membrane tension; metabolic; metal; method; methodology; mice; micelles; microdomains; microscopy; microtubules; migration; milan; millisecond; mimic; minimum; minor; mitochondria; mixed; mixing; mixtures; mobile; mobility; model; model membrane; model protein; model system; modeling; modifications; modified; modulates; modulation; moiety; molecular; molecular biology; molecular biophysics; molecular dynamics; molecular interactions; molecular level; molecular mechanism; molecule fluorescence; molecule force; molecules; monitoring; monolayers; monomeric; monomers; morphological; morphology; motif; motion; motor; movement; mrna; multiple; muscle; mutagenesis; mutant; mutated; mutations; myosin; nadh; nanoclusters; nanoparticles; nanoscale; national; native; natural; nature; ncp7; necessary; need; negative; nerve; nervous; netherlands; network; neurodegenerative; neuronal; neurons; neuroscience; neurotransmitter; neutral; neutron; new; nmr; noise; non; normal; nottingham; novel; nps; nuclear; nucleation; nucleic; nucleotide; nucleus; number; numerical; numerous; objective; observation; observed; occurrence; oligomerization; oligomers; oligonucleotide; ompf; ones; oocytes; open; opening; opposite; optical; optical microscopy; optical properties; orai1; order; organelles; organic; organisms; organization; organized; organs; orientation; original; osmotic; outer; outer membrane; overall; oxford; oxidation; oxidative; oxidized; oxygen; p2x; p53; packing; padova; pairs; palermo; parallel; parameters; parkinson; partial; particles; particular; partition; partitioning; partners; patch; pathological; pathway; patients; patterns; pcer; pdz; peak; peculiar; peg; peptide; permeability; permeation; peroxidation; peroxide; perpendicular; perturbation; pes; petersburg; pgk; phagocytosis; pharmaceutical; pharmacological; phase; phenomenon; phosphate; phosphatidylcholine; phosphatidylglycerol; phospholipid; photobleaching; photodynamic; photolysis; photon; photosynthetic; physical; physical properties; physics; physiological; physiology; picture; pigment; pisa; place; planar; planck; plant; plaques; plasma membrane; platelet; platforms; play; point; poland; polar; polarization; polarized; polymer; polymeric; polymerization; polypeptide; popc; populations; pore; porins; porous; portugal; positions; positive; possibility; possible; post; potassium; potential; powerful; ppme; precision; predictions; preliminary; prepared; presence; present; present study; presentation; pressure; presynaptic; previous; primary; prion; probability; probe; problem; process; processes; produce; production; products; profile; program; proiapp; project; proliferation; proline; promising; propagation; propensity; properties; property; protein; protein aggregation; protein binding; protein complexes; protein conformational; protein dynamics; protein function; protein interactions; protein molecules; protein stability; protein structure; protein surface; protocol; protonation; prp; psii; psm; pulse; pump; pure; purification; purified; purpose; putative; quantification; quantitative; quantum; quasi; quenching; questions; radical; raman; random; range; rapid; rate; ratios; rats; ray; rbc; reaction; reactive; real; rearrangements; recent; receptor; recognition; recombinant; reconstituted; reconstitution; recordings; recovery; redox; reduced; reflection; refolding; regime; region; regulate; regulation; regulatory; related; relationship; relative; relaxation; release; relevance; relevant; remarkable; removal; repair; replication; report; representative; repressor; republic; research; residues; resistance; resolution; resonance; respect; respiratory; response; responsible; results; reverse; reversible; review; rhodopsin; ribozymes; rich; rigid; rise; rna; role; rotational; russia; saint; salt; sample; sampling; sarcomere; saxs; scale; scanning; scattering; scheme; school; sciences; scientific; sclerosis; screening; second; secondary; section; segment; selective; selectivity; self; sense; sensing; sensitive; sensitivity; sensor; separation; sequence; series; serotonin; sers; serum; set; setup; severe; shape; shear; sheet; shg; shift; short; shorter; shows; shr; signal; signaling; significant; silicon; similar; simulations; simultaneous; single; single cell; single channel; single dna; single molecule; single protein; sirna; site; situ; size; skeletal; slices; sln; slovakia; slow; small; smaller; soce; sodium; soft; solid; soluble; solutions; solvent; source; space; spain; spatial; spatio; species; specific; specific dna; specific protein; specificity; spectra; spectroscopy; spectrum; speed; spherical; sphingomyelin; spindle; spontaneous; spr; square; stability; stabilized; stable; stages; standard; starting; state; state university; statistical; steady; stem cells; step; stimulated; stoichiometry; strain; strand; strategies; strategy; strength; stress; stretching; strong; structural changes; structural properties; structure; studied; study; subject; subsequent; substrate; subunit; sugar; suitable; superfamily; support; supramolecular; surface; surfactant; survival; sweden; switching; switzerland; syn; synapses; synaptic; synchrotron; syndrome; synko; synthesis; synthetic; synuclein; system; target; targeted; targeting; tau; tbilisi; techniques; technologies; technology; temperature; temporal; tension; terminal; terminus; terms; test; tethered; theoretical; theory; therapeutic; therapy; thermal; thermodynamic; thickness; thin; threshold; tht; time; tirf; tissue; titin; titration; tocopherol; tool; topology; total; toxic; toxicity; tracking; trafficking; trajectories; transcription; transduction; transfer; transient; transition; translational; translocation; transmembrane; transmission; transport; treatment; trieste; triplet; trp; tryptophan; tumor; turnover; tweezers; type; typical; tyrosine; u.k; u.s.a; ucp4; ukraine; ultrasound; umr; unclear; underlying; understanding; understood; unfolded; unfolding; unilamellar; unique; university; unknown; unusual; unwinding; uptake; usa; use; useful; uses; values; variable; variants; variation; variety; vectors; velocity; venom; versus; vesicles; vgsc; viability; vibrational; view; viral; virus; viruses; viscosity; visible; vitro; vivo; voltage; volume; walls; warwick; water; wavelength; waves; ways; weak; wide; wild; work; working; years; yeast; yidc; zwitterionic; zürich
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        item: #4 of 68
          id: cord-004584-bcw90f5b
      author: None
       title: Abstracts: 8th EBSA European Biophysics Congress, August 23rd–27th 2011, Budapest, Hungary
        date: 2011-08-06
       words: 106959
      flesch: 38
     summary: to that of cell proteins (amide II band at *1550 cm -1 ) Membrane proteins and peptides are acting in an environment rich in other proteins or peptides.
    keywords: 1,2; able; absence; absorption; acceptor; account; accumulation; accuracy; accurate; acetylation; acid; acidic; actin; activation; active; activities; activity; acyl; adaptation; addition; address; adhesion; adp; advanced; advantages; affinity; afm; agent; aggregates; aggregation; agreement; aim; albumin; allosteric; alpha; altered; alternative; alzheimer; amb; amino; amounts; amplitude; amyloid; analogues; analysis; angle; animal; anionic; anisotropy; antenna; anti; antibiotics; antibodies; anticancer; antimicrobial; apoptosis; applications; applied; approach; appropriate; aqueous; architecture; area; arginine; array; artificial; aspects; assay; assemblies; assembly; assignment; associated; association; atomic; atomistic; atoms; atp; atpase; attention; august; available; axis; backbone; background; bacterial; bacteriorhodopsin; band; bar; base; basis; bcd; behavior; best; beta; better; bilayer; binding; biochemical; biological; biological membrane; biology; biomembranes; biomimetic; biomolecular; biophysical; blockers; blood; body; bond; bpl; brain; breaks; breast; bsa; budapest; buffer; bulk; bundling; ca2; calcium; calculated; calculations; calorimetry; cancer; cancer cells; capable; capacity; capsid; cardiac; carotenoid; carrier; case; catalytic; cationic; causes; cavity; cell; cell adhesion; cell biology; cell division; cell imaging; cell level; cell lines; cell membrane; cell migration; cell proliferation; cell protein; cell shape; cell surface; cell types; cellular; center; central; ceramide; chain; challenge; changes; channel; chaperonin; characteristics; characterization; characterized; charge; chemical; chemistry; chemotherapy; chitosan; chlorophyll; cholesterol; chr2; chromatin; chromophore; cin8; circular; clamp; class; classical; cleavage; clinical; close; clusters; coated; coefficients; coil; coli; collagen; collective; combination; combined; common; comparison; compartments; complete; complex; complexation; complexes; complexity; components; composition; compounds; computational; computer; concentration; concept; conclusion; conditions; conductance; conductivity; configuration; confirmed; confocal; conformational; conformational changes; conjugate; connected; consequences; conserved; consistent; consists; constant; contact; content; continuous; contraction; contrast; contribute; contribution; control; conventional; conversion; core; correlated; correlation; corresponding; cortex; coupling; crac; critical; cross; crowding; crucial; cryo; crystal; crystallography; ctd; cultures; current; curvature; cycle; cyclic; cytochrome; cytokine; cytoplasmic; cytoskeleton; cytosolic; daam; damage; data; days; death; decrease; decreasing; degradation; degree; delivery; denaturation; density; department; dependent; depletion; depolarization; deposition; description; design; detailed; details; detection; determination; determined; development; devices; diagrams; diameter; dichroism; differences; different; different cell; different lipid; different membrane; different protein; differential; differentiation; difficult; diffraction; diffusion; dimensional; dimer; dimeric; dimerization; direct; direction; diseases; disordered; displacement; displays; disruption; distance; distinct; distribution; diverse; division; dna; docking; domain; donor; dose; double; dox; doxorubicin; dppc; drms; drug; dsc; dyes; dynamical; dynamics; dynamics simulations; early; effect; effective; efficiency; elastic; electric; electrochemical; electron; electrophysiological; electrostatic; elements; embryo; emission; endocytosis; endothelial; energetic; energy; engineering; enhanced; ensemble; entire; entry; environment; enzymatic; enzyme; epithelial; epr; equilibrium; erythrocyte membrane; erythrocytes; essential; etc; eukaryotic; events; evidence; example; exchange; excitation; exhibit; existence; experimental results; experimentally; experiments; exposure; expression; extended; external; extracts; ezrin; factor; family; far; fast; faster; fatty; fcs; features; fiber; fibres; fibrillar; fibrils; fibrinogen; field; filaments; film; final; findings; flexibility; flow; fluctuations; fluid; fluorescence; fluorescence correlation; fluorescence microscopy; fluorescent protein; focus; folding; following; food; force; forespore; formation; forms; fourier; fraction; fragments; france; free; frequencies; frequency; fret; ftir; function; functionalized; functioning; fundamental; fusion; future; gap; gating; gel; gene; general; generation; genetic; genome; genomic; geometry; germany; gfp; globular; gm1; goal; gold; good; gradient; gram; grant; great; green; group; growth; gtp; hand; harvesting; hcv; head; heart; heavy; helical; helices; helix; help; heme; hemoglobin; herg1; heterogeneous; high; high membrane; high protein; higher; histone; homology; host; hours; hsa; human; hungarian; hungary; hyaluronic; hydration; hydrogen; hydrophobic; hydrophobicity; hyp; hypothesis; identification; iii; illumination; image; imaging; immune; impact; important; important role; improved; inactive; increase; incubation; individual; induced; induction; influence; infrared; inherent; inhibition; inhibitors; initial; inner; insertion; inside; insights; institute; insulin; intact; integrated; integrity; intensity; interaction; interest; interesting; interface; interfacial; intermediate; intermolecular; internal; intracellular; intracellular protein; intrinsic; invasion; invasive; investigated; investigation; ionic; isoforms; isolated; isothermal; itc; kda; key; kinase; kinetics; kit; known; labeling; laboratory; lack; large; laser; lateral; laurdan; ldl; leading; leads; leakage; leiomodin2; length; level; lifetime; ligand; light; like; likely; limitations; limited; linear; lipid; lipid bilayer; lipid composition; lipid interactions; lipid membrane; lipid molecules; lipid rafts; lipid structure; liposomes; liquid; little; live cells; living; living cells; local; localization; long; loop; loss; low; lower; lymphocytes; lysozyme; machinery; macromolecular; magnetic; magnitude; mail; major; malignant; mammalian; manipulation; manner; map; marker; mass; materials; matrix; max; means; measured; measurements; measuring; mechanical; mechanism; medical; medicine; medium; melting; members; membrane; membrane binding; membrane curvature; membrane domains; membrane dynamics; membrane fusion; membrane interaction; membrane organization; membrane potential; membrane properties; membrane protein; membrane structure; membrane surface; membrane systems; membrane vesicles; metal; metastatic; method; mhc; micelles; microenvironment; microscopy; microtubule; migration; mimic; minimal; mitochondrial; mixed; mixing; mixtures; model; model lipid; model membrane; model system; modeling; modifications; modified; modulation; molecular; molecular dynamics; molecular interactions; molecular level; molecular mechanism; molecule fluorescence; molecules; monitored; monitoring; monolayers; monomeric; monomers; morphological; morphology; mother cell; motif; motility; motion; motor; movement; mrna; multiple; muscle; mutagenesis; mutants; mutations; myosin; nanoparticles; nanoscale; narrow; national; native; natural; nature; needle; negative; nerve; netherlands; network; neural; neurodegenerative; neuronal; neurons; neutron; new; nmr; non; normal; novel; nps; nrf; ns4b; nuclear; nucleation; nucleic; nucleotide; nucleus; number; numerical; numerous; observations; observed; occurring; oligomerization; oligomers; ones; open; opening; opp; opposite; opsins; optical; optimization; order; ordered; organic; organisms; organization; orientation; oriented; osmotic; outer; overall; oxidation; oxide; oxygen; packing; pairs; parallel; paramagnetic; parameters; parkinson; partial; particular; partition; patch; pathological; pathway; patients; patterns; pca; peg; pegylated; peptide; performance; peridinin; pgk; pharmaceutical; phase; phenomena; phosphate; phosphatidylcholine; phospholipids; phosphorylation; photobleaching; photochemical; photodynamic; photosensitizer; photosynthetic; photosystem; physics; physiological; picture; planck; plane; plants; plasma membrane; platelet; plus; pocket; point; poland; polar; polarity; polymerization; polymers; polypeptide; poor; popc; populations; pore; porphyrin; positive; possibility; possible; potential; powerful; precise; prepared; presence; present; present study; presentation; pressure; previous; primary; prior; probe; problems; processes; products; profile; program; progress; progression; project; proliferation; promising; properties; property; protease; protein; protein aggregation; protein binding; protein complex; protein dynamics; protein environment; protein function; protein interactions; protein stability; protein structure; protein surface; protein translocation; proton; proximal; proximity; prp; pulse; pump; pure; purification; purified; purple; purpose; putative; quality; quantitative; quantum; quenching; question; quinone; radiation; rafts; raman; random; range; rapid; rate; ray; reaction; reactive; real; recent; receptor; recognition; recombinant; recorded; recruitment; redox; reduced; reduction; reference; reflection; region; regulated; regulation; related; relationship; relative; relaxation; release; relevant; reliable; repair; replication; report; research; residues; resistance; resolution; resonance; respect; respiratory; response; responsible; resulted; results; reversible; rich; rise; rna; role; rutin; salt; samples; saxs; scale; scanning; scattering; science; screening; seca; second; secondary; secondary structure; secretion; segments; selected; selective; selectivity; self; sensing; sensitive; sensitivity; sensor; separated; separation; sequence; series; sers; serum; set; shape; sheet; shift; short; shows; signal; signaling; significant; similar; simple; simulations; simultaneous; single; single cell; single molecule; single protein; sites; situ; size; skeletal; slbs; slow; small; smaller; sodium; solid; soluble; solutions; solvent; source; space; spatial; species; specific; specific membrane; specific protein; specificity; specimens; spectra; spectrometry; spectroscopy; spectrum; speed; sphingomyelin; spin; ssbauer; stability; stabilized; stable; standard; state; steady; step; stiffness; stimuli; stoichiometry; strand; strategies; strength; stress; stretch; strong; stronger; structure; studies; study; subcellular; subsequent; substrate; subunits; sugar; suitable; super; supported; supramolecular; surface; surfactants; survival; switching; symmetry; synaptic; synthesis; synuclein; system; systematic; t cells; talk; target; targeted; targeting; tau; techniques; technology; temperature; temporal; tension; terminal; terms; test; theoretical; theory; therapeutic; therapy; thermal; thermodynamic; thickness; threshold; time; tirf; tissue; titration; tool; torque; total; toxic; toxicity; tracking; trafficking; transcription; transduction; transfer; transform; transient; transition; translocation; transmembrane; transport; treatment; trehalose; tryptophan; ttc; ttingen; ttr; ttss; tumor; tumor cells; turn; tweezers; type; typical; tyrosine; udu; unclear; understanding; unfolded; unfolding; unilamellar; unique; university; unknown; uptake; usa; use; values; variable; variations; variety; velocity; vesicles; vibrational; view; viral; virus; viruses; viscosity; vitro; vivo; voltage; volume; water; wavelength; way; weak; wide; wild; work; working; years; yeast; znpc; zwitterionic
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        item: #5 of 68
          id: cord-006556-hmzoxqu3
      author: Alibrahim, Omar S.
       title: Extracorporeal Life Support: Four Decades and Counting
        date: 2017-04-12
       words: 10160
      flesch: 41
     summary: ELSO maintains the world's largest registry of data on ECLS patients, with voluntary submission of this data. It is not uncommon for ECLS patients to be heavily sedated during the first few days.
    keywords: acceptable; acute; adult; anticoagulation; approach; ards; arterial; artery; bleeding; blood; cannulae; cannulation; cardiac; cardiopulmonary; care; cases; cdh; centers; children; circuit; common; complications; congenital; continuous; conventional; critical; data; days; decades; devices; diaphragmatic; disease; distress; early; ecls; ecls support; ecmo; ecpr; effects; elso; exchange; experience; extracorporeal; extracorporeal life; extracorporeal membrane; failure; femoral; flow; fluid; gas; group; h1n1; heart; heparin; hernia; high; improved; increase; indications; influenza; initiation; injury; lead; life; life support; lumen; lung; management; mechanical; medicine; membrane; membrane oxygenation; mode; mortality; need; neonatal; neonates; new; organization; outcomes; overall; oxygenation; pandemic; patients; pediatric; period; population; pressure; pumps; rate; recovery; registry; renal; repair; reports; respiratory; respiratory ecls; respiratory failure; results; resuscitation; review; right; risk; sedation; sepsis; severe; shock; site; study; support; surgery; surgical; survival; syndrome; therapy; time; total; unresponsive; use; vein; venovenous; ventilation; volume; vv ecls; years
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        item: #6 of 68
          id: cord-006947-nrzjedhi
      author: Dasgupta, S
       title: Nano- and microparticles at fluid and biological interfaces
        date: 2017-09-20
       words: 18461
      flesch: 45
     summary: The temporary nature of contact-line pinning can be observed for instance for metastable orientations of dumbbell-shaped particles at interfaces; the distribution of particle orientations relaxes towards the globally stable particle orientation when the system ages particle orientations For non-spherical particles, the orientation of the particles at interfaces, as well as particle shape, size, and surface properties have to be taken into account to determine adsorption energies and interface deformations.
    keywords: adhesion; aggregates; american; angle; anisotropic; applications; area; aspect; assembly; attachment; attraction; axis; bending; bilayer; biological; biological interfaces; blood; bond; calculations; capillary; capillary interactions; cells; cellular; changes; characterized; chemical; colloidal; colloidal particles; colloids; complete; contact; contact angle; contact line; copyright; corresponding; cube; curvature; curved; cylinders; cylindrical; cylindrical particles; deep; deformations; delivery; density; diagram; different; dimensional; distance; drug; dumbbell; dynamics; effect; elastic; ellipsoidal particles; elongated; emulsions; endocytosis; energies; energy; equation; example; experimental; external; field; figure; film; floatation; fluid; fluid interfaces; forces; free; froth; general; gravity; half; height; high; higher; hydrophobic; inclusions; induced; interactions; interface; interface curvature; interface deformations; interface tension; janus; janus particles; large; lead; length; like; like particles; line; linear; lipid; liquid; local; long; lowest; magnetic; mechanism; membrane; membrane curvature; membrane tension; micrometer; microscopy; model; nanoparticles; nematic; non; numerical; oil; order; orientation; parasite; partial; particle interactions; particle orientation; particle shape; particle surface; particles; permission; perpendicular; phase; planar; pressure; proc; properties; proteins; quadrupolar; radius; range; ratio; receptor; red; regime; rigidity; rocket; section; self; shape; simulations; single; size; sized particles; small; society; solid; spherical particles; spontaneous; stability; stable; states; strength; studies; submarine; surface; systems; tension; thickness; thin; tilted; tip; transition; typical; uptake; values; vesicles; viruses; water; wrapping
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        item: #7 of 68
          id: cord-008480-p41oae8e
      author: O'Callaghan, Barbara
       title: Characterization of aminopeptidase N from Torpedo marmorata kidney
        date: 2004-11-12
       words: 4418
      flesch: 47
     summary: Each of these 42 culture supernatants was used to immunoprecipitate kidney membrane proteins that had been In some experiments, when kidney membranes were pre-pared in the absence of the protease inhibitor PMSF, an additional 150 kDa band was immunoprecipitated by each of the 17 anti-180 kDa antibodies (not shown). BALB/c mice were immunized by three intraperitoneal injections (at 15-day intervals) of kidney membrane proteins (about 50/.tg emulsified proteins in Freund's adjuvant).
    keywords: acid; activity; aminopeptidase; antibodies; antibody; antigen; apical; band; basolateral; border; brush; buffer; cells; chaps; culture; domain; edta; electrophoresis; endoglycosidase; enzyme; epithelial; fig; fractions; gel; gold; gradients; human; intestinal; kda; kidney; lower; mammalian; membrane; molecular; monoclonal; naci; particles; peak; phosphate; proteins; proximal; rabbit; sds; sections; sedimentation; sequence; similar; single; sucrose; terminal; torpedo; tris; tubule
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        item: #8 of 68
          id: cord-009371-ub4p4ngr
      author: Mollenhauer, Hilton H.
       title: Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity
        date: 1990-05-07
       words: 12405
      flesch: 45
     summary: [46] reported a shift to higher density of Golgi apparatus membranes from monensin-treated barley cells, a response no obvious from work with mammalian cells. These data imply that the monensin-induced swelling of Golgi apparatus cisternae involves a proton gradmnt at or near the mature poles of the Golgi apparatus Because monensin induces a 1 1 Na+/H + exchange, and since the Van't Hoft factors for H + and Na + are practically the same [159] , the osmolanty of the cell content should not increase to cause swelhng without a net proton influx One explanation would be that the pH of Golgi apparatus vesicles is highly regulated Proton translocatlng ATP hydrolyzing enzymes (H +-ATPases) are associated with several components of cells that develop acidic intermrs such as endosomes, coated vesicles, lysosomes, and trans Golgl apparatus Clsternae
    keywords: accumulation; acidic; action; activity; affected; altered; animal; apparatus; apparatus clsternae; associated; atp; binding; biological; block; body; calcium; cardiac; cation; cattle; cause; cells; cellular; chains; changes; clsternae; coated; compartments; complexes; components; concentrations; consistent; content; cultured; cytoplasm; damage; data; degradation; dependent; differences; different; direct; disruption; effects; electron; endo; endocytic; endocytosls; endosomes; evidence; example; exchange; exit; exposure; expression; feed; fiber; fibroblasts; fig; findings; fixation; forest; formation; function; golgi; golgi apparatus; gradients; granules; greater; heart; high; human; hver; increase; inhibition; intracellular; ionophores; isolated; kidney; levels; little; liver; low; lysosomes; maturation; mechanism; membrane; mitochondria; molecules; monensin; monensin effects; monensm; monovalent; mouse; movement; muscle; myocardial; net; nonpolar; normal; observed; outer; pathways; plant; plasma; poisoning; potential; poultry; presence; present; processing; product; protein; proteoglycans; proton; range; rate; receptor; release; response; result; reticulum; reversible; rumen; secondary; secretion; secretory; sensitive; similar; sodium; species; stack; striated; studies; subcellular; surface; swelhng; swelling; swollen; synthesis; systems; times; tissues; tool; toxin; trans; transfer; transport; treatment; type; uptake; vacuoles; vesicles; vesicular; viral; virus; wide; workers; x-537a
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        item: #9 of 68
          id: cord-011888-3mvzkff6
      author: Moore, John P.
       title: Oxone(®)-Mediated TEMPO-Oxidized Cellulose Nanomaterial Ultrafiltration and Dialysis Mixed-Matrix Hollow Fiber Membranes
        date: 2020-06-15
       words: 5946
      flesch: 54
     summary: Further analysis of dialysis membranes like these will/could show the possibility of the use of less membrane area and shorter treatment times, leading to better patient health. This study is the first to focus on the implementation of OTO-CNMs into hollow fiber membranes and a comparison of these membranes for ultrafiltration and dialysis.
    keywords: area; bath; blood; bsa; calculated; casting; cellulose; clearance; coefficient; concentration; control; cta; data; dialysate; dialysis; disease; equation; feed; fiber; figure; flow; flux; form; hemodialysis; high; hollow; lysozyme; membranes; min; module; nanomaterials; nmp; oto; performance; pore; pressure; psi; pure; radius; range; rate; run; samples; sem; sieving; significant; size; solute; solution; table; testing; theoretical; time; treatment; ultrafiltration; urea; values; water
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        item: #10 of 68
          id: cord-013223-f43hks44
      author: Chronopoulos, Antonios
       title: Emerging role of bacterial extracellular vesicles in cancer
        date: 2020-10-15
       words: 5802
      flesch: 20
     summary: Tissue Barriers The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy Microbial translocation is a cause of systemic immune activation in chronic HIV infection The microbiome in cancer immunotherapy: diagnostic tools and therapeutic strategies Inter-kingdom signalling: communication between bacteria and their hosts Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli Environmentally controlled bacterial vesicle-mediated export Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi Bacterial membrane vesicles transport their DNA cargo into host cells Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function Helicobacter pylori and gastrointestinal tract adenocarcinomas Circulating bacterial membrane vesicles cause sepsis in rats Outer membrane vesicles of a human commensal mediate immune regulation and disease protection Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Toll-like receptor 4 signaling licenses the cytosolic transport of lipopolysaccharide from bacterial outer membrane vesicles Pseudomonas aeruginosa outer membrane vesicles modulate host immune responses by targeting the Toll-like receptor 4 signaling pathway Differential responses of pattern recognition receptors to outer membrane vesicles of three periodontal pathogens Mycobacteria release active A. Chronopoulos, R. Kalluri membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice Bacterial membrane vesicles mediate the release of mycobacterium tuberculosis lipoglycans and lipoproteins from infected macrophages Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes Outer membrane vesicles from probiotic and commensal Escherichia coli activate NOD1-mediated immune responses in intestinal epithelial cells Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells Aggregatibacter actinomycetemcomitans outer membrane vesicles are internalized in human host cells and trigger NOD1-and NOD2-dependent NF-kappaB activation Outer membrane vesicles prime and activate macrophage inflammasomes and cytokine secretion in vitro and in vivo Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease DNA sensing by the cGAS-STING pathway in health and disease B cell activation by outer membrane vesicles-a novel virulence mechanism Toll-like receptor signalling Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction The uptake, trafficking, and biodistribution of bacteroides thetaiotaomicron generated outer membrane vesicles Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body Metagenome analysis of bodily microbiota in a mouse model of alzheimer disease using bacteria-derived membrane vesicles in blood The healthy human blood microbiome: fact or fiction? Integration of bacterial DNA sequences has been in fact detected more frequently in human cancer cells versus normal cells, especially in gastrointestinal (GI)-related tumors with close proximity to the gut microbiome, suggesting a potential role of bacterial DNA in carcinogenesis [31] .
    keywords: access; acids; activation; antigens; bacteria; bacterium; barrier; bevs; biogenesis; blood; body; brain; cancer; cargo; cells; circulation; commensal; communication; components; composition; controls; cross; cytoplasmic; dendritic; dependent; different; direct; disease; distant; dna; endocytosis; envelope; epithelial; evidence; exosomes; extracellular; factors; formation; function; genetic; genome; gram; group; gut; healthy; host; human; immune; immunity; immunotherapy; inflammatory; inter; intestinal; kingdom; like; likely; lps; luminal; mechanism; membrane; membrane vesicles; microbial; microbiome; negative; nucleic; number; omvs; organs; outer; outer membrane; pancreatic; pathogenic; patients; peptidoglycan; plasma; positive; possibility; potential; presence; proteins; receptors; responses; rna; role; route; sensing; sequencing; species; specific; study; surface; systemic; tissue; toll; tract; tumor; underlying; universal; vesicles; virulence; wall
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        item: #11 of 68
          id: cord-014685-ihh30q6f
      author: None
       title: Posters P788 - P999
        date: 2005-09-21
       words: 38408
      flesch: 42
     summary: 12 physical property parameters of protein structure were chosen to construct a 12-dimension physical property space. These systems have proven to be also valuable as membrane mimetic structures, as promising matrices for controlled-release and delivery of proteins, vitamins and small drugs in pharmacological applications, and they offer a 3D lipid matrix for successful crystallization of membrane proteins which do not easily crystallize in bulk solution.
    keywords: -atpase; -crystallins; absence; absorption; accumulation; acid; acidic; activation; active; activity; addition; afm; agents; aggregates; aggregation; aim; alpha; amino; amphiphilic; amyloid; analogues; analysis; anionic; annealing; antibiotics; apparatus; applications; approach; aqueous; assembly; associated; association; atp; backbone; bacterial; band; base; beta; better; bilayer; binding; biochemistry; biological; biology; biophysics; blood; bovine; brils; buffer; calcium; cancer; capacity; cars; case; catalytic; cation; cells; cellular; certain; chain; changes; channels; characteristics; characterization; characterized; charge; chemical; chemistry; chemotherapy; chitosan; chlorophyll; cholesterol; ciency; cient; circular; cnrs; coil; coli; collagen; combined; common; complete; complex; complexes; components; composition; compounds; concentration; conditions; confocal; conformational; conserved; consistent; consists; content; contrast; control; conventional; conversion; copolymers; copper; correlated; correlation; cort; cross; crucial; crystal; crystal structure; ctac; cycle; damage; data; decrease; degree; delivery; denaturation; density; department; dependent; derivatives; design; details; development; dichroism; different; diffusion; dimensional; dimeric; dimerization; direct; diseases; distinct; distribution; dna; docking; domain; drug; duplex; dynamics; effect; eld; electric; electron; electrostatic; emission; encapsulation; energy; ensemble; enzyme; equilibrium; essential; evolution; exchange; excited; exhibit; exibility; exible; existence; experiments; exposure; expression; extended; external; factor; faculty; family; far; fast; faster; fhua; folding; force; forms; fragments; france; free; function; genes; germany; global; gradient; group; growth; hairpin; half; hand; heat; helical; helices; helix; high; higher; human; hydration; hydrogen; hydrophobic; hyp; identi; imaging; important; increase; individual; induced; information; inhibited; inhibition; inhibitors; insights; institute; intensity; interaction; interface; intermediate; investigation; involved; italy; japan; key; kinesin; kinetics; kissing; known; laboratory; lah4; landscape; large; laser; lead; leak; level; lhcii; life; ligand; light; like; linear; lipid; liposomes; lms; local; long; loop; loss; low; lower; luciferase; magnetic; major; maturation; mct1; mdr; means; measurements; mechanism; medical; membrane; membrane protein; metal; method; microscopy; model; modeling; modi; molecular; molecules; monomeric; motif; motor; movement; mpg; mrna; multidrug; muscle; mutant; mutation; nano; national; native; natural; nbce1; near; network; new; nity; nmr; non; nonionic; novel; nuclear; nucleic; nucleotide; number; observed; oligomerization; optical; optimization; order; organization; outer; overall; oxford; oxygen; parameters; particles; particular; pathway; peptide; permeation; phase; photosynthetic; photosystem; physical; physiological; pigment; plasma; plasmid; polymerized; polypeptide; pore; possible; post; potential; prediction; presence; present; pressure; primary; process; processes; promoter; properties; property; protease; protein; protein folding; protein structure; proteoliposomes; proton; prp; psii; pumps; puri; radiation; random; range; rapid; rate; ray; reaction; receptor; recombinant; refolding; region; related; release; remains; replication; research; residues; resistance; response; responsible; results; retinal; rna; rnas; role; rrf; rst; samples; saxs; scattering; school; sciences; screening; secondary; secondary structure; selection; self; sensitive; sequence; series; set; sheet; shift; short; signals; signi; silk; similar; simulations; single; site; size; small; sodium; solid; solution; solvation; solvent; space; speci; speci c; species; spectra; spectroscopy; stability; stabilization; stable; stacking; state; step; stochastic; strain; stress; strong; structure; studies; study; substrates; subunits; suitable; support; supramolecular; surface; synchrotron; system; target; techniques; technology; temperature; terminal; tertiary; tested; theoretical; theory; therapeutic; therapy; thermal; thermodynamic; thylakoid; time; tissue; tnt; tokyo; toxin; transfer; transition; translocation; transmembrane; transport; transporters; treatment; trna; trp; trpase; trpzipalpha; tryptophan; tumor; type; understanding; unfolded; unfolding; university; uorescence; uptake; use; values; variants; variations; vesicles; viral; virus; vitro; vivo; voltage; volume; water; wide; wild; work; yeast; yefm
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        item: #12 of 68
          id: cord-015866-65zrbo1w
      author: Wardhan, Rashmi
       title: Membrane Transport
        date: 2018-01-12
       words: 18010
      flesch: 49
     summary: ATP-binding cassette (ABC) transporters, importers, and exporters, the newly identified integral proteins, comprise a large superfamily of integral membrane proteins with diverse functions. The peripheral proteins V 1 are designated in bold alphabet like V 1 A, B, C, D, E, F, G, and H, and integral membrane proteins are known as a, b, c, c, d, and V 0 e.
    keywords: abc; acids; active; activity; affinity; alanine; alpha; amino; amino acids; animal; anion; apoptosis; aquaporins; arginine; aromatic; aspartic; atpases; bacteria; barrel; base; bicarbonate; binding; blood; bond; calcium; carboxyl; carrier; catalytic; cations; cavity; cell; central; change; channel; chloride; cholesterol; cis; class; close; coefficient; coli; complex; concentration; conformation; conserved; cycle; cysteine; cytolysin; cytoplasmic; cytosolic; dependent; different; diffusion; domain; drug; electrical; electrochemical; energy; enzyme; erythrocytes; eukaryotic; extracellular; facilitated; family; fig; flippases; form; function; gaba; gate; glucose; glutamate; glycine; gradient; gram; gramicidin; group; helices; helix; high; higher; histidine; host; human; hydrogen; hydrolysis; hydrophobic; important; inactivation; inner; integral; interaction; intestine; ion; ionophore; ions; isoforms; k2p; kidney; lacy; large; ligand; light; like; lipid; loop; lower; major; mechanism; membrane; microbial; molecules; motif; movement; muscle; nbd; negative; nmda; nonpolar; npa; nucleotide; oligomerization; open; opening; organisms; outer; passive; peripheral; permeability; pfts; phenylalanine; phosphate; phosphorylation; physiological; plasma; polar; pore; porins; positive; potassium; potential; present; process; property; proteins; proton; pump; receptor; region; regulated; regulation; release; residues; retinal; reversible; rhodopsin; role; secondary; segments; selectivity; sequence; sglt1; short; single; site; size; small; sodium; specific; specificity; state; strands; structure; subclasses; substrate; subunit; sugar; surface; terminal; tmd; toxins; translocation; transmembrane; transport; transporters; type; type atpases; valinomycin; voltage; walker; water
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        item: #13 of 68
          id: cord-016938-pk76snuy
      author: Suh, Hwal (Matthew)
       title: Collagen Fabrication for the Cell-based Implants in Regenerative Medicine
        date: 2008
       words: 6427
      flesch: 32
     summary: Outcome of the regenerative medical treatment completely depends on the viability of delivered cells. 16938 cord_uid: pk76snuy Though transplantation of cells, tissue or organ has been regarded as an ideal approach, scarcity of donor is a practical barrier in clinics.
    keywords: acid; adhesion; adhesive; agents; apatite; applicable; appropriate; artificial; atelocollagen; biodegradable; biological; biomaterials; body; bonds; bone; cells; chain; characteristics; collagen; components; composite; concentration; consists; control; cultured; days; dense; dermal; diameter; disease; donor; edc; extracellular; fibroblasts; film; forms; gel; gene; group; growth; hours; human; hyaluronic; immune; implantation; implants; intermolecular; laminin; layer; layered; matrix; mechanical; membrane; method; molecules; mpeg; natural; non; organ; oval; ozone; patient; pla; plga; polyurethane; pores; porous; procedure; process; proliferation; property; recipient; skin; soluble; solution; strength; structural; substances; surface; synthetic; therapeutic; therapy; tissue; transplantation; treatment; tube; type; use; vacuum; wound; xenogeneic
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        item: #14 of 68
          id: cord-017566-dvxrwzqw
      author: González, María Eugenia
       title: Viral Proteins that Enhance Membrane Permeability
        date: 2005
       words: 4494
      flesch: 37
     summary: This occurs with a number of virus glycoproteins (GP) that are known to increase cell membrane permeability, such as the human immunodeficiency virus gp41 (Chernomordik et al., 1994; Arroyo et al., 1995) , the Ebola virus GP (Yang et al., 2000) , the cytomegalovirus US9 protein (Maidji et al., 1996) , the Vaccinia virus A38L protein (Sanderson et al., 1996) , rotavirus VP7 and NS4 proteins (Charpilienne et al., 1997; Newton et al., 1997) , the hepatitis C virus E1 protein (Ciccaglione et al., 1998) , and the alphavirus E1 protein (Nyfeler et al., 2001; Wengler et al., 2003) . It should be noted that the entry of these compounds, in fact, determines a modification in cell membranes, which in some cases does not directly correlate with cell death.
    keywords: acids; activity; addition; agents; alpha; alterations; amino; animal; antiviral; calcium; carrasco; case; cells; cellular; channel; compounds; different; domain; early; entry; et al; expression; figure; formation; function; fusion; glycoprotein; gonzalez; gp41; hepatitis; hiv; human; hydrophobic; hygromycin; immunodeficiency; infection; inhibitors; late; mammalian; membrane; modification; molecular; molecules; number; particles; peptide; permeability; permeabilization; plasma; pore; protein; release; rotavirus; sarcin; small; terminus; translation; type; viral; viroporins; virus; viruses; vpu
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        item: #15 of 68
          id: cord-020712-l9cn0n99
      author: Ohnishi, Shun-Ichi
       title: Chapter 9 Fusion of Viral Envelopes with Cellular Membranes
        date: 2008-05-30
       words: 11713
      flesch: 50
     summary: Several review articles have been published on virus membrane fusion activity (White r t a / . The pH characteristics of virus membrane fusion activity will be determined by the pH dependencies of the conformational change of the fusion protein and the neutralization of the fusogenic segment.
    keywords: acidic; acidic ph; activity; amino; asano; bha; bilayer; binding; carboxyl; cause; cell; cell fusion; cell membranes; change; cholesterol; close; clustering; conformational; dependence; different; early; efficient; electron; endosomes; energy; entrance; entry; envelope; envelope fusion; erythrocyte; et al; example; fatty; fig; fluorescence; forest; free; fusion; fusion activity; fusogenic; genome; ghosts; glu; glycoprotein; groups; ha2; hemagglutinin; hemolysis; hemolytic; higher; hvj; hydrophobic; hydrophobic segment; incubation; induced; infection; influenza; influenza virus; inhibition; interaction; isolated; large; lipid; liposomes; low; low ph; lower; membrane; membrane fusion; mobilization; neutral; neutral ph; nucleotide; ohnishi; parent; peptide; ph dependence; phospholipids; presence; proteins; proteolytic; protonation; range; rapid; reaction; receptor; replication; residues; section; segment; semliki; sendai; sendai virus; sequence; sfv; similar; site; specific; spin; stomatitis; structure; studies; surface; table; target; terminal; terminus; transfer; value; vesicles; vesicular; viral; virus; viruses; vsv; white; yoshimura
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        item: #16 of 68
          id: cord-020714-h1fevqcw
      author: Compans, Richard W.
       title: Membrane Glycoproteins of Enveloped Viruses
        date: 2008-05-30
       words: 14170
      flesch: 35
     summary: The carbohydrate content and glycoproteins of the virion An electron microscope study of the presence or absence of neuraminic acid in enveloped viruses On the structure of the influenza virus envelope Inhibition of glycoprotein biosynthesis of influenza virus by D-glucosamine and 2-deoxy-~-glucose Association of influenza virus proteins with cytoplasmic fractions Activation of influenza A viruses by trypsin treatment A sedimentable component of allantoic fluid and.its relationship to influenza viruses Separate pathways of maturation ofthe major structural proteins of vesicular stomatitis virus Subsequent biochemical studies revealed that high concentrations of 2-dG or Dglucosamine prevented the synthesis of influenza virus glycoproteins (Klenk et al., 1972b Nakamura and Compans, 1978a) .
    keywords: acid; activity; amino; analysis; antibody; antigenic; assembly; available; avian; bilayer; carbohydrate; case; cell; cell membrane; cell surface; cellular; chains; choppin; cleavage; compans; complex; components; composition; cross; cytoplasmic; daltons; data; different; distinct; distribution; effects; electron; envelope; enveloped viruses; et al; evidence; external; fig; fusion; glucosamine; glycopeptides; glycoproteins; glycosylation; groups; hemagglutinin; herpes; high; host; host cell; hydrophobic; incorporation; infected; infectivity; influenza; influenza virus; information; interactions; internal; isolated; klenk; lack; landsberger; laver; leukemia; likely; lipid; lipid bilayer; major; mannose; maturation; membrane; membrane proteins; model; molecular; molecule; nakamura; neuraminidase; oligosaccharide; paramyxoviruses; particles; plasma; plasma membrane; polypeptides; portion; possess; precursor; presence; present; process; protease; proteolytic; recent; receptors; replication; residues; results; role; sarcoma; sendai; sfv; shape; sialic; similar; sindbis; sindbis virus; size; specific; spike; stomatitis; stomatitis virus; strains; structure; studies; surface; sv5; synthesis; treatment; type; vesicular; viral; viral envelope; viral glycoproteins; viral membrane; viral proteins; virions; virus; virus groups; virus particles; viruses; vsv; wagner
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        item: #17 of 68
          id: cord-020788-a33vcapl
      author: Gottardi, Cara J.
       title: Signals and Mechanisms of Sorting in Epithelial Polarity
        date: 2008-05-22
       words: 13913
      flesch: 29
     summary: Yeast syntaxins Ssolp and Sso2p belong to a family of related membrane proteins that function in vesicular transport Role ofmicrotubules in polarized delivery of apical membrane proteins to the brush border ofthe intestinal epithelium Distribution of transport proteins over animal cell membranes Podocytosis of small molecules and ions by caveolae The calmodulin antagonist, W-13, alters transcytosis, recyclingand morphology ofthe endocyticpathway in Madine-Darby canine kidney cells Mutational and secondary structural analysis of the basolateral sorting signal of the polymeric immunoglobulin receptor Vesicular stomatitis virus glycoprotein is sorted and concentrated during export from the endoplasmic reticulum Cloning of a rab3 isotype predominately expressed in adipocytes The NPXY internalization signal of the LDL receptor adopts a reverse turn conformation Biogenesis of the rat hepatocyte plasma membrane in vivo: Comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation. The differential distribution of membrane proteins between the plasmalemmal surfaces of polarized epithelial cells enables these cells to both respond to and effect changes upon their environment in a directed fashion.
    keywords: acid; analysis; apical; apical membrane; apical proteins; apical sorting; approaches; arf; atpase; basolateral; basolateral membrane; basolateral sorting; basolateral surface; bfa; binding; budding; caplan; cell surface; cells; certain; chimeric; class; clathrin; clear; coated; compartment; complex; components; context; control; cytoplasmic; default; delivery; dependent; determinant; differences; different; distinct; distribution; domain; ectodomain; endocytosis; epithelial; epithelial cells; et al; events; evidence; example; fact; family; field; functional; fusion; general; glycoprotein; golgi; gpi; gsls; gtp; heterotrimeric; human; hypothesis; immunoglobulin; important; information; internalization; intestinal; intracellular; key; kidney; ldlr; level; like; line; llc; localization; low; machinery; matter; matter et; mdck; mdck cells; mechanisms; membrane; membrane proteins; molecular; molecules; multiple; mutagenesis; necessary; neurons; number; particular; pathway; phenotype; pigr; pits; plap; plasma; plasma membrane; polarity; polarized; polarized cells; polarized epithelial; possible; present; process; proteins; proximal; rab; rab8; rabs; recent; receptor; recognition; regulated; related; residues; responsible; results; review; role; roth; rothman; second; secretion; secretory; sequence; share; signal; similar; small; sodium; sorted; sorting; specific; structural; studies; study; subunit; surface; system; tail; targeting; terminal; tgn; tight; traffic; transcytosis; transmembrane; transport; type; tyrosine; vesicle; vesicular; virus; vsvg; yeast
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        item: #18 of 68
          id: cord-022354-aqtceqqo
      author: HUNTER, ERIC
       title: Membrane Insertion and Transport of Viral Glycoproteins: A Mutational Analysis
        date: 2012-12-02
       words: 17775
      flesch: 32
     summary: Perlman and Halvorson (1983) and von Heijne (1983) have examined sequences of a number of membrane proteins and have described amino acid sequence patterns that allow prediction of signal peptidase cleavage sites with greater than 90% accuracy. Many cell surface and membrane proteins of animal viruses are bound to the lipid bilayer by a membrane-spanning hydrophobic peptide close to the carboxy terminus of the polypeptide (reviewed by Warren, 1981; Armstrong et aL, 1981) .
    keywords: acid; addition; amino; amino acid; analysis; anchor; anchor domain; apical; apparatus; arginine; assembly; basolateral; bilayer; biosynthesis; bitopic; budding; carbohydrate; carboxy; cell; cell surface; chain; cleavage; cloned; coli; complex; components; cytoplasmic; cytoplasmic domain; deletion; different; dna; domain; endoplasmic; env; env gene; envelope; epithelial; et al; eukaryotic; experiments; expression; external; fig; forest; forest virus; form; functional; fusion; g protein; gene; gene product; genetic; glycoproteins; glycosylated; glycosylation; golgi; golgi complex; gp37; gp85; hemagglutinin; hydrophobic; hydrophobic amino; hydrophobic domain; infected; influenza; influenza virus; insertion; interaction; intracellular; intracellular transport; length; leu; leu leu; long; maturation; mature; mechanisms; membrane; membrane glycoproteins; membrane proteins; molecular; molecule; mutant; mutant protein; mutations; nonpermissive; normal; nuclear; nucleotide; observed; pathway; peptidase; peptide; plasma; plasma membrane; point; polarized; polypeptide; possibility; possible; potential; pr95; precursor; presence; process; processing; product; prokaryotic; protein; protein translocation; protein transport; recognition; recombinant; reduced; region; rer; residues; results; reticulum; role; rose; roth et; rous; rsv; sarcoma; secretion; secretory; semliki; sensitive; sequence; ser; signal; signal peptide; signal sequence; similar; single; site; sorting; specific; stomatitis; stomatitis virus; stop; structure; studies; subcellular; substitution; surface; surface transport; sv40; systems; targeting; temperature; terminal; terminus; translocation; transmembrane; transport; type; val; vesicular; viral; virus; virus glycoprotein; virus hemagglutinin; virus membrane; viruses; vsv; wild; wills; zilberstein et
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        item: #19 of 68
          id: cord-022504-tk7v4hoj
      author: None
       title: Environmental and safety issues with nanoparticles
        date: 2012-03-16
       words: 14098
      flesch: 50
     summary: Where f is the characteristic function that expresses particle size, particle concentration, particle composition, and so on [2, 3] . Influence of particle diameter on lower limit of particle concentration for explosion.
    keywords: acid; aerosol; air; airborne; amounts; applied; area; asbestos; assessment; attention; biological; boron; bsa; cake; carbon; case; cells; chemical; cleanroom; cmp; coal; colloid; combustion; composition; compounds; concentration; control; corona; cyto; deposition; devices; diameter; diesel; different; diffusion; dioxide; discharge; distribution; dna; dots; droplets; dust; effective; effects; electrostatic; elements; emission; emitted; environment; example; exhaust; explosion; exposure; fibers; field; fig; figure; filter; filtration; fine; fine particles; flow; flux; force; form; formation; fraction; fullerenes; gas; general; glass; group; hand; health; high; human; humic; important; increase; indoor; industrial; industry; influence; isoelectric; kinds; large; laser; liquid; lower; lung; mass; materials; membrane; metal; method; mobility; model; molecular; molecules; nanomaterials; nanoparticles; nanosized; nanotubes; number; nvr; oil; order; organic; particle concentration; particle diameter; particle size; particles; particulate; peak; permeate; point; potential; pressure; primary; processes; processing; production; products; protein; pulmonary; quantum; range; rate; reaction; recent; removal; resistance; respiratory; results; safety; sedimentation; separation; size; smaller; solution; sources; studies; substances; surface; technologies; technology; thousands; time; total; toxicity; trace; treatment; type; typical; use; value; wastewater; water; weight; working
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        item: #20 of 68
          id: cord-022538-1g9kmpdi
      author: Makino, Hisao
       title: ENVIRONMENTAL AND SAFETY ISSUES WITH NANOPARTICLES
        date: 2008-05-20
       words: 14290
      flesch: 50
     summary: Where f is the characteristic function that expresses particle size, particle concentration, particle composition, and so on [2, 3] . Influence of particle diameter on lower limit of particle concentration for explosion.
    keywords: acid; aerosol; air; airborne; amounts; applied; area; asbestos; assessment; attention; biological; boron; bsa; cake; carbon; case; cells; chemical; cleanroom; cmp; coal; colloid; combustion; composition; compounds; concentration; control; corona; cyto; deposition; devices; diameter; different; diffusion; dioxide; discharge; distribution; dna; dots; droplets; dust; effective; effects; electrostatic; elements; emission; emitted; environment; example; exhaled; exhaust; explosion; exposure; fibers; field; fig; figure; filter; filtration; fine; fine particles; flow; flux; force; form; fraction; fullerenes; gas; general; glass; group; hand; health; high; human; humic; important; increase; indoor; industrial; industry; influence; isoelectric; issues; kinds; large; laser; liquid; lower; lung; mass; materials; membrane; metal; method; mobility; model; molecular; molecules; nanomaterials; nanoparticles; nanosized; nanotubes; number; nvr; oil; order; organic; particle concentration; particle diameter; particle size; particles; particulate; peak; permeate; point; possibility; potential; pressure; printers; processes; processing; production; products; protein; pulmonary; quantum; range; rate; reaction; recent; relationship; removal; resistance; results; safety; sedimentation; separation; size; smaller; solid; solution; sources; studies; substances; surface; technologies; technology; thousands; time; total; toxicity; trace; treatment; type; use; value; wastewater; water; weight; working
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        item: #21 of 68
          id: cord-023200-3caevjvh
      author: Falanga, Annarita
       title: Membranotropic peptides mediating viral entry
        date: 2018-02-13
       words: 6066
      flesch: 36
     summary: [70, 71] As for enveloped virus fusion peptides, the amphipathic a-helix seems to be a key structural motif also for non-enveloped viruses. [3] On the other hand, the entry of non-enveloped viruses, which lacking the outer viral membrane are unable to take advantage of the cellular mechanism of membrane fusion, involves the activation of viral lytic factors that induce cell membrane rupture.
    keywords: ability; able; activity; amino; amphipathic; applications; bilayer; binding; capsid; cell; cellular; cholesterol; class; cleavage; common; conformation; different; disruption; domain; entry; enveloped; enveloped viruses; exposure; fact; factors; fhv; formation; fusion; fusion peptides; fusion proteins; g peptide; helical; helices; helix; host; hydrophobic; influenza; insertion; interaction; key; l1n; leaflet; lipid; lytic; mechanism; membrane; membrane fusion; membranotropic; membranotropic peptides; non; penetration; peptides; pore; presence; present; process; proteins; receptor; region; release; residues; role; similar; structure; surface; target; terminal; terminus; university; viral; viral fusion; viruses
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        item: #22 of 68
          id: cord-028738-ing07qma
      author: Roy, Nimisha
       title: Prototype of a Smart Microfluidic Platform for the Evaluation of SARS-Cov-2 Pathogenesis, Along with Estimation of the Effectiveness of Potential Drug Candidates and Antigen–Antibody Interactions in Convalescent Plasma Therapy
        date: 2020-07-08
       words: 5661
      flesch: 49
     summary: Cells from petri dish is seeded inside the device channels (both upper and lower) at specified cell density (cells/ml). Organ-on-chip (OOC), particularly lung-on-chip, is one such approach which combines the potential of microfluidics, cell culture and molecular biology into a single miniaturised platform.
    keywords: addition; adhesion; alveolar; antibody; available; blood; candidates; capillary; cell; cell culture; channels; chip; contamination; convalescent; cost; covid-19; culture; current; dead; device; discovery; disease; drug; effective; fabrication; fig; hoechst; human; inside; interface; layer; life; like; live; lower; lung; major; market; master; media; membrane; microfluidic; microscope; min; model; nitrocellulose; ooc; organ; oxygen; pandemic; pathogenesis; patients; pbs; pdms; plasma; platform; polyester; polymer; porous; potential; process; protocol; rapid; results; sars; single; staining; study; su-8; technology; testing; therapy; time; toxicity; upper; viability; virus
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        item: #23 of 68
          id: cord-030961-5gzc7193
      author: Wang, Jiajun
       title: Adhesive contact between cylindrical (Ebola) and spherical (SARS-CoV-2) viral particles and a cell membrane
        date: 2020-08-28
       words: 4335
      flesch: 50
     summary: It is therefore important to develop an understanding of how virus particles infect our body's cells. understand the mechanics of initial virus adhesion to the cell.
    keywords: adhesion; adhesive; applied; attachment; axisymmetric; bending; case; cell; cell membrane; conditions; contact; continuum; cov-2; cylindrical; deflection; dimensionless; displacement; ebola; energy; external; fig; force; free; host; limit; mechanics; membrane; model; normalized; parameters; particle; radius; region; results; sars; small; spherical; stiffness; surface; tension; viral; virus; width; work
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        item: #24 of 68
          id: cord-034898-zjfhpum2
      author: Patangi, Sanjay Orathi
       title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective
        date: 2020-11-07
       words: 7533
      flesch: 37
     summary: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition A comparison of pumpcontrolled retrograde trial off to arterio-venous bridging for weaning from venoarterial extracorporeal membrane oxygenation Extracorporeal membrane oxygenation for infant postcardiotomy support: significance of shunt management Fontan physiology revisited Clinical outcomes in patients after extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock: a single-centre experience of 92 cases Outcomes of venoarterial extracorporeal membrane oxygenation patients requiring multiple episodes of support Longterm survival in adults treated with extracorporeal membrane oxygenation for respiratory failure and sepsis Long-term prognosis after extracorporeal life support in refractory cardiogenic shock -results from a real-world cohort Patients' self-assessed functional status in heart failure by New York Heart Association class: a prognostic predictor of hospitalizations, quality of life and death Long-term outcomes of extracorporeal membrane oxygenation support for postcardiotomy shock Financial and clinical outcomes of extracorporeal mechanical support The comparative use of ventricular assist devices: differences between Europe and the United States Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Acknowledgements Weaning of extracorporeal membrane oxygenation using continuous hemodynamic transesophageal echocardiography Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock Venoarterial extracorporeal membrane oxygenation in cardiogenic shock Pump controlled retrograde trial off from VA-ECMO Levosimendan may improve weaning outcomes in venoarterial ECMO patients Pharmacologic approaches to weaning from cardiopulmonary bypass and extracorporeal membrane oxygenation Functional evaluation of sublingual microcirculation indicates successful weaning from VA-ECMO in cardiogenic shock Clinical pearls of venoarterial extracorporeal membrane oxygenation for cardiogenic shock Extracorporeal membrane oxygenation, an anesthesiologist's perspective: physiology and principles.
    keywords: acute; adult; analysis; anticoagulation; aortic; aptt; arterial; artery; associated; bleeding; blood; bridge; cannulae; cannulation; cardiac; cardiogenic; cardiotomy; care; central; children; circuit; circulation; clinical; common; complications; congestion; cost; damage; data; days; decision; disease; duration; dysfunction; ecmo; elso; end; exchange; extracorporeal; extracorporeal membrane; factors; failure; fig; flow; function; gas; guidelines; heart; heparin; higher; important; incidence; infection; injury; intra; lactate; levels; life; liver; lower; lung; management; map; mechanical; membrane; membrane oxygenation; metabolic; min; monitoring; mortality; myocardial; need; non; organ; outcomes; oxygenation; patients; pccs; pediatric; perfusion; period; peripheral; physiology; platelet; positive; post; postcardiotomy; pressure; pulmonary; pulsatile; pump; rate; recovery; renal; respiratory; review; right; risk; rrt; runs; shock; studies; successful; support; surgery; survival; system; systemic; therapy; thrombocytopenia; thrombosis; time; transfusion; trial; use; vascular; veno; venoarterial; venous; ventilation; ventricular; volume; weaning
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        item: #25 of 68
          id: cord-035248-m5517zgn
      author: Stokes, John W.
       title: Bleeding, Thromboembolism, and Clinical Outcomes in Venovenous Extracorporeal Membrane Oxygenation
        date: 2020-11-09
       words: 2387
      flesch: 25
     summary: Key Words: adult; critical care; extracorporeal membrane oxygenation; hemorrhage; respiratory distress syndrome; thromboembolism B leeding and thromboembolism are common during venovenous extracorporeal membrane oxygenation (ECMO) (1). Dr. Casey was supported Predictive factors of bleeding events in adults undergoing extracorporeal membrane oxygenation Severe respiratory failure, extracorporeal membrane oxygenation, and intracranial hemorrhage Anticoagulation practices during venovenous extracorporeal membrane oxygenation for respiratory failure.
    keywords: analysis; anticoagulation; bleeding; clinical; cohort; continuous; data; duration; ecmo; events; extracorporeal; extracorporeal membrane; hospital; initiation; membrane; membrane oxygenation; outcomes; oxygenation; patients; prior; randomized; strategies; study; support; survival; thromboembolism; trial; venovenous; worse
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        item: #26 of 68
          id: cord-103739-mmkrwj8t
      author: Snijder, Eric J.
       title: A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis
        date: 2020-03-24
       words: 3813
      flesch: 35
     summary: However, it is not clear that DMVs always play the primary role 421 in virus replication that we demonstrate here for CoV. For picornaviruses, for example, virus- were freeze-substituted in a Leica AFS2 system with 0.1% (wt/vol) uranyl acetate as 576 previously described [71] , with the only modification that acetone was replaced by ethanol 577 from the last washing step before Lowycril infiltration onwards. The comprehensive analysis presented here demonstrates that viruses across different CoV 371 genera induce essentially the same type of membrane structures.
    keywords: analysis; assembly; autoradiography; beta; cells; characterization; complex; coronavirus; cov; different; distance; dmss; dmvs; double; electron; emulsion; endoplasmic; fig; hepatitis; ibv; infected; infection; labelling; large; membrane; mers; microscopy; mouse; organelles; particles; present; proteins; radioactive; random; regions; replication; respiratory; reticulum; rna; samples; sars; sections; signal; sites; spherules; structures; subcellular; syndrome; synthesis; uridine; vesicles; viral; virus; viruses; vrna; zippered
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        item: #27 of 68
          id: cord-103812-ls6zgipi
      author: Norris, Rachael P.
       title: Gap junction internalization and processing in vivo: a 3D immuno-electron microscopy study
        date: 2020-06-30
       words: 4810
      flesch: 50
     summary: A review Differential modulation of rat follicle cell gap junction populations at ovulation Degradation of annular gap junctions of the equine hoof wall Endosome-tocytosol transport of viral nucleocapsids Endocytic processing of connexin43 gap junctions: a morphological study Autophagy: a pathway that contributes to connexin degradation Oral tolerance can be established via gap junction transfer of fed antigens from CXCR1+ macrophages to CD103+ dendritic cells The fine structure of granulosa cell nexuses in rat ovarian follicles Influence of aldehyde fixation on the morphology of endosomes and lysosomes: quantitative analysis and electron tomography Endosomal compartmentalization in three dimensions: implications for membrane fusion Gap junctions Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption Localization of phosphorylated Connexin 43 using serial section immunogold electron microscopy Colocalization of connexin 43 and connexin 45 but absence of connexin 40 in granulosa cell gap junctions of rat ovary This tissue was used because it has large numbers of Cx43 gap junctions (Okuma et al, 1996 ; Norris et al., 2008 Norris et al., , 2017 Baena et al., 2020) , which are caused to internalize in response to hormone (Larsen et al., 1987) .
    keywords: annular; antibody; area; average; budding; cell; connexin; connexons; connexosomes; cx43; cytoplasm; degradation; double; electron; endosomes; et al; evidence; falk; fig; figure; fission; follicles; formation; frozen; fusion; gap; gap junctions; granulosa; high; inner; internalization; internalized; invaginated; junctions; membrane; modifications; modified; mouse; multivesicular; norris; outer; outward; ovarian; plasma; pressure; processing; sections; serial; small; structures; surface; tape; tissue; transfer; vesicles; video; volume
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        item: #28 of 68
          id: cord-104279-choywmwd
      author: None
       title: Membrane protein sorting in the yeast secretory pathway: evidence that the vacuole may be the default compartment
        date: 1992-10-01
       words: 9975
      flesch: 41
     summary: According to the vacuolar default model for yeast membrane protein sorting, not only must ER and Golgi membrane proteins have sorting signals specifying their retention in the appropriate compartment, but plasma membrane proteins are predicted to have sorting information that prevents their localization to the vacuole. Mutations in clathrin may affect both the retention of Golgi membrane proteins and the functional integrity of the sorting pathway (Seeger and Payne, 1992b) .
    keywords: a20; a22; a27; acid; alp; amino; analysis; antibody; apparatus; bamhi; blunt; cells; cerevisiae; compartment; cytoplasmic; cytoplasmic domain; dap2; data; default; delivery; domain; dpap; dpap b; emr; encoding; et al; fig; fluorography; fragment; fusion; fusl; gene; golgi; golgi membrane; high; hindlii; immunofluorescence; indirect; intracellular; inv; invertase; kbp; kex2p; laczp; localization; lumenal; lumenal domain; manuscript; membrane; membrane proteins; mlui; model; mutagenesis; mutant; mutations; nh2; non; page; pathway; plasma; plasma membrane; plasmid; processing; promoter; proteins; publication; receptor; region; residues; resulted; results; retention; roberts; role; sds; secretory; sequence; signal; sites; sorting; staining; ste/3; strain; surface; table; targeting; terminal; thorner; transmembrane; transport; type; vacuolar; vacuolar membrane; vacuole; vat2p; wild; yeast
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        item: #29 of 68
          id: cord-253366-03cg831z
      author: Chakraborty, Hirak
       title: Mechanistic insights of host cell fusion of SARS-CoV-1 and SARS-CoV-2 from atomic resolution structure and membrane dynamics
        date: 2020-07-22
       words: 5043
      flesch: 39
     summary: A quantitative model for membrane fusion based on low-energy intermediates Energetics of intermediates in membrane fusion: comparison of stalk and inverted micellar intermediate mechanisms The many mechanisms of viral membrane fusion proteins Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin Epidemiology, genetic recombination, and pathogenesis of coronaviruses Role of lipids in virus replication Mechanisms of coronavirus cell entry mediated by the viral spike protein Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission Atomic structure of the ectodomain from HIV-1 gp41 Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion The sweet spot: defining virus-sialic acid interactions Cellular entry of the SARS coronavirus Receptor-induced conformational changes in the SU subunit of the avian sarcoma/leukosis virus A envelope protein: implications for fusion activation Studies on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus Wild-type and mutant hemagglutinin fusion peptides alter bilayer structure as well as kinetics and activation thermodynamics of stalk and pore formation differently: mechanistic implications A specific point mutant at position 1 of the influenza hemagglutinin fusion peptide displays a hemifusion phenotype HIV-1 fusion peptide decreases bending energy and promotes curved fusion intermediates Fusion peptide from influenza hemagglutinin increases membrane surface order: an electron-spin resonance study The Gaussian curvature elastic energy of intermediates in membrane fusion Energetics of vesicle fusion intermediates: comparison of calculations with observed effects of osmotic and curvature stresses Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions gp41 transmembrane domain interacts with the fusion peptide: implication in lipid mixing and inhibition of virus-cell fusion Fusion peptides and the mechanism of viral fusion Viral fusion proteins: multiple regions contribute to membrane fusion Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells Hypothesis: spring-loaded boomerang mechanism of influenza hemagglutinin-mediated membrane fusion The three lives of viral fusion peptides HIV entry and envelope glycoprotein-mediated fusion The polar region consecutive to the HIV fusion peptide participates in membrane fusion A host-guest system to study structure-function relationships of membrane fusion peptides Early and late HIV-1 membrane fusion events are impaired by sphinganinelipidated peptides that target the fusion site Sendai virus internal fusion peptide: structural and functional characterization and a plausible mode of viral entry inhibition Are fusion pepties good model to study viral cell fusion Lipids in biological membrane fusion Relationship between the infectivity of influenza virus and the ability of its fusion peptide to perturb bilayers Membrane structure and fusiontriggering conformational change of the fusion domain from influenza hemagglutinin The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface Structure and function of the complete internal fusion loop from Ebolavirus glycoprotein 2 The amino-terminal region of the fusion peptide of influenza virus hemagglutinin HA2 inserts into sodium dodecyl sulfate micelle with residues 16-18 at the aqueous boundary at acidic pH. Oligomerization and the conformational flexibility NMR structure, localization, and vesicle fusion of Chikungunya virus fusion peptide Interaction of the Dengue virus fusion peptide with membranes assessed by NMR: The essential role of the envelope protein Trp101 for membrane fusion Solid-state NMR spectroscopy of the HIV gp41 membrane fusion protein supports intermolecular antiparallel beta sheet fusion peptide structure in the final six-helix bundle state Fully hydrophobic HIV gp41 adopts a hemifusion-like conformation in phospholipid bilayers Structurerelated roles for the conservation of the HIV-1 fusion peptide sequence revealed by Nuclear Magnetic Resonance Conformation and lipid interaction of the fusion peptide of the paramyxovirus PIV5 in anionic and negative-curvature membranes from solid-state NMR A strong correlation between fusogenicity and membrane insertion depth of the HIV fusion peptide Structure and dynamics of micelle-associated human immunodeficiency virus Membrane fusion, one of the most fundamental processes for the survival of eukaryotes, occurs when two closely apposed lipid bilayers merge into a continuous single bilayer and the inner contents are mixed with each other.
    keywords: acid; acute; atomic; bilayers; binding; cell; cell fusion; characterization; conformational; coronavirus; cov-2; covs; cryo; domain; entry; envelope; figure; formation; fps; fusion; fusion peptide; fusion protein; glycoprotein; gp41; helical; helix; hemagglutinin; hemifusion; high; hiv; host; host cell; hr1; human; infection; infectivity; influenza; interaction; lfp; like; lipid; long; mechanism; membrane; membrane fusion; mers; micelle; model; nmr; peptide; pore; process; protein; rbd; receptor; region; residues; resolution; respiratory; sars; sequence; severe; spike; stalk; state; structure; surface; syndrome; transmembrane; trimeric; viral; virus; viruses
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        item: #30 of 68
          id: cord-257754-pqxkyg8z
      author: Reggiori, Fulvio
       title: Membrane Origin for Autophagy
        date: 2006-07-21
       words: 9237
      flesch: 32
     summary: This notion is corroborated by the fact that the totality of Atg9 is associated with membranes Reggiori et al., 2005b) . Nice et al., 2002; Reggiori et al., 2003 Reggiori et al., , 2004a .
    keywords: addition; apparatus; association; atg8; atg9; autophagosomes; autophagy; avd; bacteria; bilayers; biogenesis; cargo; cargoes; cells; cellular; cerevisiae; characterization; class; compartments; completion; complex; components; conjugation; contrast; cvt; cytoplasm; cytosolic; degradation; diverent; double; early; endoplasmic; endosomal; endosome; essential; et al; event; example; expansion; factors; fengsrud; fig; formation; functions; fusion; gabarap; gate-16; golgi; hepatocytes; homologs; host; human; hydrolases; identification; important; induced; intracellular; involved; isolation; kim; kim et; kirisako; kirisako et; klionsky; large; late; lc3; legionella; like; lipid; lysosome; machinery; mammalian; markers; maturation; mechanism; membrane; mitochondria; mouse; organelles; origin; pas; pastoris; pathogens; pathway; peroxisomes; pexophagy; pneumophila; polymorpha; possibility; possible; process; protein; reggiori; replication; resident; reticulum; retrieval; reunanen; rna; role; route; saccharomyces; secretory; section; selective; shintani; small; specific; starvation; structures; studies; study; surface; system; table; targeting; transport; trayc; ubiquitin; unclear; unknown; vacuole; vesicles; viruses; yeast
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        item: #31 of 68
          id: cord-264996-og3sg0qw
      author: Howell, Gareth J.
       title: Cell Biology of Membrane Trafficking in Human Disease
        date: 2006-09-17
       words: 20376
      flesch: 29
     summary: Sorting of proteins from donor to target membranes involves the recognition of cytoplasmic sequences in membrane proteins by clathrin-associated AP complexes. However, their exact role in the internalization of membrane proteins and soluble protein ligands is controversial.
    keywords: aberrant; acceptor; accessory; accumulation; acid; actin; activation; activity; adaptor; addition; akt; albinism; aldrich; alpha; alzheimer; anterograde; antigen; ap3; apoptosis; apparatus; assembly; associated; atp7a; autosomal; basolateral; binding; biogenesis; biology; blood; brain; breast; budding; cancer; cargo; cause; caveolae; caveolin-1; cdc42; cell; cellular; cftr; channel; chaperones; chediak; cholesterol; cis; class; clathrin; clinical; coated; compartment; complex; complexes; components; compromised; condition; conformation; congenital; conserved; constitutive; contrast; control; copii; copper; correct; ctls; cytoplasmic; cytoskeleton; cytosolic; defective; defects; deficiency; degradation; delivery; density; dependent; diabetes; disease; disorders; display; diverent; docking; domain; dominant; donor; dynamics; dynamin; dysfunction; dystrophy; early; eea1; endocytic; endocytosis; endoplasmic; endosomal; endosome; endothelial; enzymes; epithelial; ergic; ergic-53; essential; et al; evector; events; evidence; example; exit; expression; factor; familial; family; fission; formation; forms; function; fusion; gene; genetic; golgi; golgi apparatus; golgi transport; golgins; griscelli; growth; gtpase; hermansky; higashi; hiv; host; hsp90; human; human disease; hypercholesterolemia; identification; immunodeficiency; immunological; implications; infection; inhibition; inhibitors; insulin; interactions; intermediates; internalization; internalized; intracellular; kda; key; kidney; kinase; large; leukemia; levels; like; lipid; lipoprotein; localization; long; loss; low; lung; lymphocytes; lysosomal; lysosomes; macrophages; major; mammalian; manner; maturation; mechanisms; membrane; membrane protein; menkes; mice; microtubule; model; molecular; molecule; motif; motor; mouse; movement; munc13; muscle; mutant; mutations; myosin; negative; network; neurological; neuronal; new; novel; number; ocrl1; organelles; p115; particles; pathway; patients; peptide; phagosome; phosphate; plasma; plasma membrane; platelet; potential; present; primary; processing; product; progression; proliferation; proteasome; protein; protein transport; pudlak; rab27a; rab5a; rafts; range; receptor; recruitment; recycling; reduced; regulated; regulation; related; release; renal; resident; response; results; retention; reticulum; retrograde; review; role; secretion; secretory; sequence; signaling; single; small; snare; soluble; sorting; specific; step; storage; structure; subsequent; subunit; surface; sv40; synapse; synaptic; syndrome; system; target; targeting; tau; tethering; tgn; therapy; tissues; trafficking; transfer; translocation; transmembrane; transport; traycking; treatment; tumor; type; understanding; uptake; vesicles; vesicular; viral; virus; viruses; wasp; wiskott; yeast
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        item: #32 of 68
          id: cord-265887-g5zhoyo9
      author: Mukherjee, Shruti
       title: Host-membrane interacting interface of the SARS coronavirus envelope protein: Immense functional potential of C-terminal domain
        date: 2020-08-11
       words: 9093
      flesch: 30
     summary: Analysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in coronavirus assembly Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues Protein aggregation in a membrane environment Protein aggregation and membrane lipid modifications under lactic acid stress in wild type and OPI1 deleted Saccharomyces cerevisiae strains Biological phase separation: cell biology meets biophysics Membrane lipids: where they are and how they behave SARS coronavirus E protein in phospholipid bilayers: an x-ray study Membrane topology and insertion of membrane proteins: search for topogenic signals Another triple-spanning envelope protein among intracellularly budding RNA viruses: the torovirus E protein Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Identifying SARS-CoV-2 Coevolution in defining the functional specificity Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes Improving the accuracy of transmembrane protein topology prediction using evolutionary information Advantages of combined transmembrane topology and signal peptide prediction--the Phobius web server Analysis of membrane and surface protein sequences with the hydrophobic moment plot Trends in substitution models of molecular evolution The rapid generation of mutation data matrices from protein sequences MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms Membrane topology of coronavirus E protein Characterization of the coronavirus mouse hepatitis virus strain A59 small membrane protein E Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus Coronavirus virulence genes with main focus on SARS-CoV envelope gene Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication 2020. (44) The absence of a canonical cleaved signal sequence suggests equal likelihood for the protein to be a type II (with its C-terminal targeted to the ER lumen) or type III (with its N-terminal targeted to the ER lumen) membrane protein.
    keywords: acid; activity; acute; aggregates; aggregation; amino; amyloid; amyloidogenic; analysis; assembly; associated; association; bilayer; binding; budding; cell; cellular; changes; channel; compartments; complex; composition; conformation; conformers; conserved; coronavirus; coronavirus envelope; cov; cov e; crucial; curvature; designing; different; disulfide; domain; drug; dynamic; e protein; envelope protein; environment; ergic; essential; events; evidence; experimental; fact; figure; formation; functional; fusion; golgi; high; host; host cell; host membrane; hydrophobic; infection; insight; interactions; interface; intervention; intracellular; like; lipid; localization; machinery; mechanism; membrane; membrane protein; membranous; model; molecular; motif; oligomerization; packaging; particle; particular; pathogenesis; pathway; peptide; phase; potential; prediction; primary; propagation; protein ion; protein sequence; proteins; receptor; region; release; replication; residues; respiratory; role; sars; sars coronavirus; sars cov; secretory; segment; sequence; severe; signal; site; specific; structural; studies; study; syndrome; system; targeted; targets; terminal; therapeutic; tk9; tmd; topology; trafficking; transmembrane; understanding; useful; viral; viroporin; virus e; viruses
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        item: #33 of 68
          id: cord-269756-tid8a464
      author: Basso, Luis G. M.
       title: SARS-CoV fusion peptides induce membrane surface ordering and curvature
        date: 2016-11-28
       words: 12265
      flesch: 41
     summary: I viral membrane fusion Mechanisms of Virus Membrane Fusion Proteins Virus membrane-fusion proteins: more than one way to make a hairpin Structure and function of membrane fusion peptides Are fusion peptides a good model to study viral cell fusion? Structural and dynamic characterization of the interaction of the putative fusion peptide of the S2 SARS-CoV virus protein with lipid membranes A second SARS-CoV S2 glycoprotein internal membrane-active peptide. Calorimetric and Monolayer Studies Interaction of the C2 domain from protein kinase C epsilon with model membranes Network formation of lipid membranes: Triggering structural transitions by chain melting Some aspects of the phase behavior of charged lipids Lipid bilayer pre-transition as the beginning of the melting process Membrane fusion between liposomes composed of acidic phospholipids and neutral phospholipids induced by melittin: A differential scanning calorimetric study Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes Interaction of a peptide model of a hydrophobic transmembrane alpha-helical segment of a membrane protein with phosphatidylethanolamine bilayers: differential scanning calorimetric and Fourier transform infrared spectroscopic studies Nature of the thermal pretransition of synthetic phospholipids: dimyristolyl-and dipalmitoyllecithin Thermal analysis of lipids, proteins and biological membranes.
    keywords: acyl; anionic; bilayer; binding; cell; chain; changes; concentration; core; coronavirus; cov; cov fusion; curvature; data; dehydration; density; different; dipope; domain; dph; dppg; dpps; dpptc; dsc; dynamics; effect; electron; eseem; esr; experiments; fig; fluid; formation; free; fusion; fusion peptides; gel; glycero-3; glycoprotein; group; head; head group; high; higher; hydrophobic; ifp; important; increase; interactions; label; leaflet; like; lipid; lipid bilayers; lipid head; local; mechanism; membrane; membrane curvature; membrane dehydration; membrane fusion; model; model membranes; mol%; molecular; molecules; negative; nitroxide; opposing; ordering; outer; packing; parameters; pcsl; peak; peptides; phase; phospholipids; popa; pore; positive; probe; process; properties; protein; putative; region; resonance; result; role; rotational; samples; sars; sars fp; sars fusion; spectra; spike; spin; state; strength; structural; studies; study; supplementary; surface; table; temperature; time; transition; vesicles; viral; viral fusion; viral membrane; water; zwitterionic
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        item: #34 of 68
          id: cord-272666-3uidpr79
      author: Doyle, Nicole
       title: Infectious Bronchitis Virus Nonstructural Protein 4 Alone Induces Membrane Pairing
        date: 2018-09-06
       words: 7506
      flesch: 48
     summary: As the role in membrane rearrangements for nsp3 and 4 is well-established for several nidoviruses and considering that nsp6 may also play some role, here we investigated the role that these three nsps play in the formation of IBV membrane rearrangements. A Key Role for Nonstructural Protein 3 in the Remodeling of Intracellular Membranes Open Reading Frame 1a-Encoded Subunits of the Arterivirus Replicase Induce Endoplasmic Reticulum-Derived Double-Membrane Vesicles Which Carry the Viral Replication Complex Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex Evolving the largest RNA virus genome Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4.
    keywords: 3xflag; able; addition; anti; areas; associated; beaur; bronchitis; cells; cellular; complex; coronavirus; cov; cytoplasmic; df1; df1 cells; different; disordered; dmvs; double; electron; endoplasmic; expression; figure; fisher; formation; gfp; hepatitis; host; ibv; induced; infected; infectious; interaction; large; length; like; localization; m41; mcherry; membrane; membrane rearrangements; mers; mhv; nonstructural; nsp3; nsp4; nsp6; nsps; pairing; pbs; plasmids; presence; proteins; puncta; rearrangements; replication; result; reticulum; rna; role; sars; scientific; sections; small; spherules; strains; structures; study; vesicles; viral; virus; viruses; zer
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        item: #35 of 68
          id: cord-274101-vm9nh8lc
      author: Perez Espitia, Paula Judith
       title: Bioactive Peptides: Synthesis, Properties, and Applications in the Packaging and Preservation of Food
        date: 2012-02-29
       words: 12728
      flesch: 31
     summary: Current EU approved additives and their E numbers Defensins: antimicrobial peptides of innate immunity Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins Principles of mass transfer Development of cellulose acetate-based antimicrobial food packaging materials for controlled release of lysozyme Polymer surface modification for the attachment of bioactive compounds Development and characterization of an antimicrobial packaging film coating containing nisin for inhibition of Listeria monocytogenes Antimicrobial plastic film: physico-chemical characterization and nisin desorption modeling Innovative multilayer antimicrobial films made with Nisaplin ® or nisin and cellulosic ethers: physico-chemical characterization, bioactivity and nisin desorption kinetics Simulating diffusion model and determining diffusivity of potassium sorbate through plastics to develop antimicrobial packaging films The role of cationic antimicrobial peptides in innate host defences Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Antimicrobial activities of amphiphilic peptides covalently bonded to a water-insoluble resin A coating for use as an antimicrobial and antioxidative packaging material incorporating nisin and [alpha]-tocopherol Studies on anticancer activities of antimicrobial peptides The antibacterial activity of magainin I immobilized onto mixed thiols self-assembled monolayers Proteomics for studying cancer cells and the development of chemoresistance Antifungal properties and mode of action of psacotheasin, a novel knottin-type peptide derived from Psacothea hilaris Antifungal activity of synthetic peptide derived from halocidin, antimicrobial peptide from the tunicate, Halocynthia aurantium Peptide antimicrobial agents Chemical synthesis of peptides and proteins Properties of nisin-incorporated polymer coatings as antimicrobial packaging materials Bioactive peptides: production and functionality Thermal, mechanical and water vapor barrier properties of sodium caseinate films containing antimicrobials and their inhibitory action on Listeria monocytogenes Antifungal mechanism of SMAP-29 (1-18) isolated from sheep myeloid mRNA against Trichosporon beigelii Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses Recombinant production of antimicrobial peptides in Escherichia coli: a review Peptide-derivatized dendrimers inhibit human cytomegalovirus infection by blocking virus binding to cell surface heparan sulfate Sínteses química e enzimática de peptídeos: princípios básicos e aplicações High-pressure processing and antimicrobial biodegradable packaging to control Listeria monocytogenes during storage of cooked ham Development and characterization of an active polyethylene film containing Lactobacillus curvatus CRL705 In animals, antimicrobial peptides are produced mainly in those tissues exposed to adverse conditions such as skin, eyes, and lungs, which are more likely to be in contact with microorganisms (Zasloff 2002; Papo and Shai 2003) .
    keywords: ability; acid; active; active packaging; activities; activity; addition; agents; amino; antibacterial; antifungal; antimicrobial; antimicrobial activity; antimicrobial packaging; antimicrobial peptides; antitumor; antiviral; appendini; applications; astm; attached; bacteria; bacteriocins; barrel; barrier; binding; bioactive; bioactive peptides; biological; bond; cancer; carcinogenic; carcinogenic cells; cationic; cell membrane; cells; cellular; cellulose; chains; changes; characterization; chemical; chromatography; coating; coli; components; compounds; concentration; conditions; contact; control; covalent; cytoplasmic; development; different; diffusion; direct; effects; electrostatic; entry; figure; film; food; food packaging; formation; functionalization; groups; hand; heparan; high; host; hotchkiss; hpmc; hydrolysis; hydrophobic; important; incorporated; incorporation; increase; interaction; jenssen; large; layer; low; main; mass; materials; matrix; mechanical; mechanism; membrane; methods; microorganisms; migration; model; molecules; natural; new; nisin; normal; number; packaging; pediocin; peg; peptide; peptide bond; peptide synthesis; polymeric; polymers; pores; presence; present; preservation; process; products; properties; protection; proteins; purification; reaction; related; release; researchers; residues; resistance; result; selective; separation; sequence; significant; solid; solubility; solution; specific; stave; structure; studies; study; sulfate; surface; synthesis; synthetic; table; target; techniques; temperature; test; time; type; use; value; vapor; virus; water
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        item: #36 of 68
          id: cord-276456-oa6hh7ky
      author: Collins, R.N.
       title: 5.14 The Biophysics of Membrane Fusion
        date: 2012-05-03
       words: 9190
      flesch: 36
     summary: hemagglutinin impair or abolish membrane fusion activity New insight into the spring-loaded conformational change of influenza virus hemagglutinin Leash in the groove mechanism of membrane fusion A host-guest system to study structure-function relationships of membrane fusion peptides Structural intermediates in influenza haemagglutinin-mediated fusion Composition and functions of the influenza fusion peptide Membrane fusion by influenza hemagglutinin Studies on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus Hypothesis: spring-loaded boomerang mechanism of influenza hemagglutinin-mediated membrane fusion Early endosomal SNAREs form a structurally conserved SNARE complex and fuse liposomes with multiple topologies The cytoplasmic tail slows the folding of human immunodeficiency virus type 1 Env from a late prebundle configuration into the six-helix bundle Fusion peptide of influenza hemagglutinin requires a fixed angle boomerang structure for activity Locking the kink in the influenza hemagglutinin fusion domain structure Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers Multiple local contact sites are induced by GPI-linked influenza hemagglutinin during hemifusion and flickering pore formation Secondary structure, orientation, oligomerization, and lipid interactions of the transmembrane domain of influenza hemagglutinin Endosome-to-cytosol transport of viral nucleocapsids Conformational changes and fusion activity of influenza virus hemagglutinin of the H2 and H3 subtypes: effects of acid pretreatment Reversible pH-dependent conformational change of reconstituted influenza hemagglutinin Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion SNAREs-energies for membrane fusion Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution Energetics and dynamics of SNAREpin folding across lipid bilayers Single molecule probing of SNARE proteins by atomic force microscopy Is assembly of the SNARE complex enough to fuel membrane fusion Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs Structure and function of SNARE and SNARE-interacting proteins Structure of proteins involved in synaptic vesicle fusion in neurons Exocytosis requires asymmetry in the central layer of the SNARE complex SNARE complex zero layer residues are not critical for N-ethylmaleimide-sensitive factor-mediated disassembly Testing the 3Q:1R 'rule': mutational analysis of the ionic 'zero' layer in the yeast exocytic SNARE complex reveals no requirement for arginine Exocytotic mechanism studied by truncated and zero layer mutants of the C-terminus of SNAP-25 Dynamic structure of lipid-bound synaptobrevin suggests a nucleationpropagation mechanism for trans-SNARE complex formation The SNARE complex from yeast is partially unstructured on the membrane Structural basis for the inhibitory role of tomosyn in exocytosis Transmembrane segments of syntaxin line the fusion pore of Ca 2 þ -triggered exocytosis Single vesicle millisecond fusion kinetics reveals number of SNARE complexes optimal for fast SNARE-mediated membrane fusion Docking and fast fusion of synaptobrevin vesicles depends on the lipid compositions of the vesicle and the acceptor SNARE complex-containing target membrane Reconstitution of Rab-and SNARE-dependent membrane fusion by synthetic endosomes Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurations Structural transitions in the synaptic SNARE complex during Ca 2 þ -triggered exocytosis Novel targets and catalytic activities of bacterial protein toxins Receptor and substrate interactions of clostridial neurotoxins X-ray structure of a neuronal complexin-SNARE complex from squid Three-dimensional structure of the complexin/SNARE complex The synaptic vesicle protein CSP alpha prevents presynaptic degeneration Ddi1, a eukaryotic protein with the retroviral protease fold Different domains of the UBL-UBA ubiquitin receptor, Ddi1/Vsm1, are involved in its multiple cellular roles A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1 A crucial interplay between protein conformations and lipid membrane energetics emerges as the guiding principle for the regulation and mechanism of membrane fusion in biological systems.
    keywords: -terminal; activity; amino; approach; assembly; bilayers; binding; biological; biological fusion; biological membrane; bundle; cell; changes; clear; coil; complex; complexes; composition; conformational; curvature; cytoplasmic; diaphragm; different; disassembly; domain; dynamin; energetics; energy; evidence; example; exocytosis; extended; figure; fission; force; formation; function; fusion; fusion peptide; fusion pore; fusion proteins; ha2; helix; hemagglutinin; hemifusion; high; hydrophobic; important; influence; influenza; influenza hemagglutinin; initial; interaction; interior; intermediates; intracellular; ionic; key; kinetics; lead; length; lipid; lipid membrane; low; mechanism; membrane; membrane fusion; mixing; model; molecular; molecules; multiple; neck; open; packing; parallel; pathway; peptides; plasma; plasma membrane; pore; pore formation; post; protein; ptdins-4,5; rearrangements; region; regulation; release; residues; role; single; snare; snare complex; snare proteins; specific; spontaneous; structure; studies; sufficient; synaptic; synaptobrevin; synaptotagmin; syntaxin; target; target membrane; tmds; topological; transmembrane; vesicle; viral; viral fusion; virus; water
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        item: #37 of 68
          id: cord-279463-bli8hwda
      author: Lipp, Joachim
       title: The membrane-spanning segment of invariant chain (Iγ) contains a potentially cleavable signal sequence
        date: 1986-09-26
       words: 6280
      flesch: 59
     summary: Membrane insertion might occur in a loop-like fashion as this scheme can most easily explain how the different membrane topologies of membrane proteins are achieved (Engelman and Steitz, 1981) . Membrane proteins are also inserted into the ER membrane by an SRP-mediated mechanism (Anderson et al., 1983; Rottier et al., 1985; Spiess and Lodish, 1986; Lipp and Dobberstein, 1986) .
    keywords: acid; addition; amino; amino acid; cell; chain; claesson; cleavable; cleavage; cleaved; coding; cytoplasmic; deletion; dobberstein; domain; end; et al; exoplasmic; figure; free; fusion; glycosylated; hydrophobic; insertion; iycat; lanes; lipp; membrane; membrane insertion; membrane proteins; microsomal; molecular; peptidase; position; presence; protein; proteinase; region; residues; secretory; segment; sequence; signal; signal peptidase; signal sequence; site; system; terminal; terminus; translation; type
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        item: #38 of 68
          id: cord-284690-ogu1gmcb
      author: da Cunha, Nicolau B.
       title: The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts
        date: 2016-11-23
       words: 9495
      flesch: 29
     summary: Overview: global and local impact of antibiotic resistance The emergence of peptides in the pharmaceutical business: from exploration to exploitation Mechanisms and consequences of bacterial resistance to antimicrobial peptides Antibiotic strategies in the era of multidrug resistance The expanding scope of antimicrobial peptide structures and their modes of action The antifungal plant defensin AhPDF1.1b is a beneficial factor involved in adaptive response to zinc overload when it is expressed in yeast cells Engineered cationic antimicrobial peptides to overcome multidrug resistance by ESKAPE pathogens Magnifection: a new platform for expressing recombinant vaccines in plants CRISPR/Cas9 for genome editing: progress, implications and challenges Antimicrobial peptides targeting Grampositive bacteria Gram-positive bacterial cell envelopes: the impact on the activity of antimicrobial peptides Antimicrobial peptides and their pore/ion channel properties in neutralization of pathogenic microbes Understanding bacterial resistance to antimicrobial peptides: from the surface to deep inside Induced bacterial cross-resistance toward host antimicrobial peptides: a worrying phenomenon New edge of antibiotic development: antimicrobial peptides and corresponding resistance Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant Staphylococcus aureus Cardiolipin prevents membrane translocation and permeabilization by daptomycin Heterogeneity of mprF sequences in methicillin-resistant Staphylococcus aureus clinical isolates: role in cross-resistance between daptomycin and host defense antimicrobial peptides Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content D-Alanylation of teichoic acids promotes group A Streptococcus antimicrobial peptide resistance, neutrophil survival, and epithelial cell invasion Lipopolysaccharide endotoxins Antimicrobial peptide resistance of Vibrio cholerae results from an LPS modification pathway related to nonribosomal peptide synthetases A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system A group B streptococcal pilus protein promotes phagocyte resistance and systemic virulence Protein GRAB of Streptococcus pyogenes regulates proteolysis at the bacterial surface by binding a2-macroglobulin Bacterial biofilm: structure, function, and antimicrobial resistance Peptide therapeutics: current status and future directions Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Antimicrobial peptides (AMPs) as drug candidates: a patent review Quality specifications for peptide drugs: a regulatorypharmaceutical approach Antimicrobial peptides stage a comeback Future directions for peptide therapeutics development Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug-resistant pathogens Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Antimicrobial peptides in toroidal and cylindrical pores Novel engineered peptides of a phage lysin as effective antimicrobials against multidrug resistant, Acinetobacter baumannii Antimicrobial peptides: versatile biological properties Interaction-site prediction for protein complexes: a critical assessment Biopharmaceutical production in plants: problems, solutions and opportunities N-glycosylation of plant recombinant pharmaceuticals Production and glycosylation of plant-made pharmaceuticals: the antibodies as a challenge Expression of rat b(1,4)-N-acetylglucosaminyltransferase III in Nicotiana tabacum remodels the plant-specific N-glycosylation End-tagging of ultra-short antimicrobial peptides by W/ F stretches to facilitate bacterial killing Engineered chimeric peptides as antimicrobial surface coating agents toward infection-free implants D-Enantiomeric peptides that eradicate wildtype and multi-drug resistant biofilms and protect against lethal Pseudomonas aeruginosa infections Membrane insertion and orientation of polyalanine peptides: a (15)N solid-state NMR spectroscopy investigation Structural and functional characterization of a multifunctional alanine-rich peptide analogue from Pleuronectes americanus Chemistry for peptide and protein PEGylation PEG-peptide conjugates Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase Global analysis of peptide cyclization efficiency The effects of the C-terminal amidation of mastoparans on their biological actions and interactions with membrane-mimetic systems Characterization of antimicrobial peptides toward the development of novel antibiotics Antifungal plant defensins: mechanisms of action and production Lanthipeptides: chemical synthesis versus in vivo biosynthesis as tools for pharmaceutical production Chemical synthesis of proteins Synthetic therapeutic peptides: science and market Dengue fever virus and Japanese encephalitis virus synthetic peptides, with motifs to fit HLA class I haplotypes prevalent in human populations in endemic regions, can be used for application to skin Langerhans cells to prime antiviral CD8+ cytotoxic T cells (CTLs): a novel approach to the protection of humans Expression systems for heterologous production of antimicrobial peptides Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs Plant antimicrobial peptides Engineering viral expression vectors for plants: the 'full virus' and the 'deconstructed virus' strategies Plant viral vectors for delivery by Agrobacterium Viral vectors for the expression of proteins in plants Expanding the genetic editing tool kit: ZFNs, TALENs, and CRISPR-Cas9 The CRISPR-Cas system for plant genome editing: advances and opportunities The CRISPR/Cas9 system for plant genome editing and beyond Development and applications of CRISPR-Cas9 for genome engineering Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. key: cord-284690-ogu1gmcb authors: da Cunha, Nicolau B.; Cobacho, Nicole B.; Viana, Juliane F.C.; Lima, Loiane A.; Sampaio, Kamila B.O.; Dohms, Stephan S.M.; Ferreira, Arthur C.R.; de la Fuente-Núñez, César; Costa, Fabrício F.; Franco, Octávio L.; Dias, Simoni C. title: The next generation of antimicrobial peptides (AMPs) as molecular therapeutic tools for the treatment of diseases with social and economic impacts date: 2016-11-23 journal: Drug Discov Today DOI: 10.1016/j.drudis.2016.10.017 sha: doc_id: 284690 cord_uid: ogu1gmcb Anti-infective drugs have had a key role in the contemporary world, contributing to dramatically decrease mortality rates caused by infectious diseases worldwide.
    keywords: acid; active; activities; activity; addition; advances; aeruginosa; agents; amino; amps; antibacterial; antibiotic; antimicrobial; antimicrobial activity; antimicrobial peptides; approach; associated; aureus; bacteria; bilayer; biofilm; biological; biosynthesis; candidates; cas9; case; cationic; cell; chemical; cleavage; clinical; coding; common; composition; crispr; cytoplasmic; defense; design; development; different; discovery; dna; double; drug; dsbs; ecaps; editing; effects; efficient; engineering; expression; formation; gene; generation; genetic; genome; glycans; glycosylation; gram; high; higher; host; human; hydrophobic; iii; immune; important; improved; increase; infective; innate; interactions; interesting; levels; lipid; low; magnifection; main; major; mdr; mechanisms; membrane; microorganisms; model; modifications; molecular; molecules; multiple; natural; negative; new; non; novel; occurring; pathogens; pathways; peptides; phase; phop; plant; platform; pore; positive; post; potential; presence; present; production; promising; properties; protein; quality; rational; recombinant; residues; resistance; response; screening; sequence; short; single; sites; size; specific; specificity; stability; strains; strategy; structure; surface; synthetic; system; target; technology; therapeutic; tobacco; toroidal; transcription; translational; translocation; trials; use; vaccine; variety; vectors; viral; virus; vitro; wall
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        item: #39 of 68
          id: cord-285620-oawrnmhy
      author: Fahimirad, Shohreh
       title: Efficient removal of water bacteria and viruses using electrospun nanofibers
        date: 2020-08-16
       words: 6770
      flesch: 29
     summary: Liquidity Nanotech Corporation has created electrospun nanofiber membrane made water purification cartridge with superior flow rate, about a cup per minute, good microbiological retention, 6-log bacteria reduction, 4-log virus reduction and 6-log cyst reduction and simple usage process (https://product.statnano.com/product/1981/liquidity-water-purification-cartridge). The present work reviews previous studies on the production and application of electrospun nanofibers as antimicrobial water filtration membranes.
    keywords: ability; activity; agents; ammonium; antibacterial; antimicrobial; antiviral; application; applied; area; bactericidal; bioactive; biocides; biofouling; carbon; cell; chemical; composite; contact; control; diameter; different; disinfection; drinking; effective; effects; efficiency; electrochemical; electrospinning; electrospun; electrospun nanofibers; electrostatic; environmental; et al; fabricated; fabrication; fahimirad; filter; filtration; flux; function; growth; high; incorporation; inhibition; ions; lanthanum; layer; leaching; log; low; materials; mean; mechanical; membrane; method; microfiltration; modification; mukherjee; nanofiber; nanofibrous; nanomaterials; nanoparticles; nanotubes; non; novel; number; pan; parameters; performance; permeability; point; polymer; pore; porosity; potential; pressure; process; promising; properties; purification; quaternary; r n; range; rate; recent; reduction; rejection; release; removal; research; retention; review; silver; size; solution; structure; studies; surface; synthesis; techniques; time; treatment; viruses; wang; water; zno
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        item: #40 of 68
          id: cord-287093-9mertwj7
      author: Netherton, Christopher L
       title: Virus factories, double membrane vesicles and viroplasm generated in animal cells
        date: 2011-10-12
       words: 4333
      flesch: 34
     summary: This suggests that virus replication occurs in the CM rather than DMVs. The hepatitis NS5A protein also binds PI4KIIIa and stimulates enzyme activity and knockdown of PI4KIIIa prevents formation of the membranous web associated with virus replication [30 ,31 ] .
    keywords: arf1; assembly; autophagosomes; autophagy; cells; cellular; complex; coronavirus; cytoplasmic; cytosol; dmvs; double; endoplasmic; face; factories; formation; gbf1; golgi; hepatitis; host; house; infection; inhibition; invaginations; kinase; large; lc3; membrane; membrane vesicles; microtubule; mtoc; organelles; phosphate; phosphatidylinositol-4; pi4kiiib; picornaviruses; plant; pore; proteins; rdrp; recruitment; replicase; replication; reticulum; rna; role; sites; spherule; strand; synthesis; vesicles; viral; viroplasm; virus; viruses
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        item: #41 of 68
          id: cord-289541-y7lewk1t
      author: Zhang, Li-Zhi
       title: Fabrication of a lithium chloride solution based composite supported liquid membrane and its moisture permeation analysis
        date: 2006-05-01
       words: 4043
      flesch: 55
     summary: Consequently, Water transfer in liquid membrane [22] : where D wl is water diffusivity in liquid membrane (m 2 s −1 ) and C w is the difference of water concentration in liquid membrane solution (kg m −3 ) between the two sides of liquid membrane. In contrast to solid membranes, moisture diffusion in liquid membranes (∼10 −9 m 2 s −1 [19, 20] , diffusion coefficients) is several orders higher than that in solid membranes.
    keywords: air; cap; cell; chamber; composite; concentration; constant; dehumidification; difference; diffusion; diffusivity; equation; fig; flow; gap; heat; humidity; hydrophilic; kg m; knudsen; layer; licl; liquid; liquid membrane; lower; mass; mean; membrane; moisture; mol; mthr; number; outlet; performance; permeation; pressure; protective; pvdf; radius; rate; recovery; resistance; solution; stream; supported; surface; temperature; test; thickness; total; transfer; transport; vapor; ventilation; water
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        item: #42 of 68
          id: cord-294842-aesiff1f
      author: Romero-Brey, Inés
       title: Membranous Replication Factories Induced by Plus-Strand RNA Viruses
        date: 2014-07-22
       words: 11053
      flesch: 35
     summary: In addition, after multiple rounds of virus replication, tubular structures were also observed in the vicinity of VPs. As discussed earlier [119] , amongst these viruses two main architectures of remodeled membranes (morphotypes) can be found that may reflect two alternative strategies to induce the membranous microenvironments required to allow virus replication (summarized in Table 1 ).
    keywords: active; addition; alterations; analysis; architecture; assembly; association; autophagy; average; biogenesis; bovine; case; cells; characterization; clusters; cms; compartments; complex; complexes; connected; coronavirus; cov; cpvs; cvs; cycle; cytoplasm; dengue; denv; diameter; different; dimensional; distinct; dmvs; double; dsrna; electron; encephalitis; endoplasmic; expression; factories; family; fhv; figure; flavivirus; forest; formation; genus; golgi; hcv; hepatitis; host; induction; infected; infection; insect; inside; intracellular; invaginations; involved; kun; large; like; localization; lumen; lysosomes; machinery; members; membrane; membrane structures; membrane vesicles; membranous; morphology; mosaic; network; nonstructural; ns4a; ns4b; nsp1; outer; particles; pathway; plant; plasma; poliovirus; polymerase; pore; production; protein; rearrangements; recent; replicase; replication; rer; results; reticulum; rna; rna replication; rna synthesis; role; sars; semliki; similar; single; sites; size; small; spherules; strain; strand; structures; studies; study; surface; synthesis; tbev; tick; tubules; ultrastructural; vacuoles; vesicles; viral; viral rna; virions; virus; virus replication; viruses; vps; wnv
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        item: #43 of 68
          id: cord-298019-gf2asni1
      author: Galdiero, Stefania
       title: gH625: A milestone in understanding the many roles of membranotropic peptides
        date: 2014-10-12
       words: 8593
      flesch: 31
     summary: Selfoligomerization of membrane embedded fusion peptides has been proposed to be responsible of inhibition [52, 53] . The preference of tryptophan for membrane interfaces Use of hydrophobic moment plot methodology to aid the identification of oblique orientated α-helices Antimicrobial peptides and viral fusion peptides: how different they are? Antimicrobial peptides: promising compounds against pathogenic microorganisms Membrane fusion and fission: enveloped viruses Recent progress of cellpenetrating peptides as new carriers for intracellular cargo delivery Mechanism of membrane fusion by viral envelope proteins Viral membrane fusion Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution Retrovirus envelope domain at 1.7 angstrom resolution Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation Structural basis for coronavirus-mediated membrane fusion.
    keywords: ability; able; acid; active; activity; amino; amphipathic; applications; aromatic; barrier; bbb; bilayer; binding; blood; brain; cell; cell membrane; class; concentration; conformational; crystal; data; delivery; dendrimer; design; different; direct; domain; drug; drug delivery; entry; envelope; fact; feature; function; functionalization; functionalized; fusion; fusion peptide; fusion proteins; fusogenic; gh625; glycoprotein; helical; helix; herpes; herpes simplex; histidine; hiv; hiv-1; hydrophobic; hydrophobic peptides; hydrophobicity; identification; important; influenza; inhibition; inhibitors; insertion; interaction; interface; intracellular; large; lipid; liposomes; mechanism; membrane; membrane bilayer; membrane fusion; membranotropic; membranotropic peptides; molecules; nature; novel; particular; penetrating; peptides; physical; potential; presence; present; process; properties; proteins; regions; residues; role; sequences; simplex; simplex virus; structure; studies; surface; synthetic; system; target; tat; terminal; therapeutic; translocation; type; uptake; viral; viral fusion; virus; virus type; viruses; vivo
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        item: #44 of 68
          id: cord-299270-fwbz3t25
      author: Lemieux, M. Joanne
       title: Structure and function of proteins in membranes and nanodiscs
        date: 2020-08-22
       words: 3037
      flesch: 33
     summary: In order to address this, Muench and colleagues have developed a method to transfer membrane proteins from SMALPs into amphipols or detergents for downstream analysis [3] . Isolation of intramembrane proteases in membrane-like environments Factors influencing the solubilization of membrane proteins from Escherichia coli membranes by styrene-maleic acid copolymers Styrene maleic-acid lipid particles (SMALPs) into detergent or amphipols: An exchange protocol for membrane protein characterisation Microfluidic diffusional sizing probes lipid nanodiscs formation Detergent-free isolation of native red blood cell membrane complexes Dynamics and structural communication in the ternary complex of fully phosphorylated V2 vasopressin receptor, vasopressin, and beta-arrestin 1 Ligand-induced conformational changes in a SMALP-encapsulated GPCR Detergent-free extraction of a functional low-expressing GPCR from a human cell line Intrinsically disordered regions regulate the activities of ATP binding cassette transporters Application of fluorescence correlation spectroscopy to study substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2 Expression and detergent free purification and reconstitution of the plant plasma membrane Na(+)/H(+) antiporter SOS1 Solution structure of the cytoplasmic domain of NhaP2 a K(+)/H(+) antiporter from Vibrio cholera Characterization of multimeric daptomycin bound to lipid nanodiscs formed by calcium-tolerant styrene-maleic acid co-polymer Solution structure and oligomeric state of the E. coliglycerol facilitator Lipid dynamics in nanoparticles formed by maleic acid-containing copolymers: EPR spectroscopy and molecular dynamics simulations The effect of hydrophobic alkyl sidechains on size and solution behaviors of nanodiscs formed by alternating styrene maleamic copolymer SLC26A7 protein is a chloride/bicarbonate exchanger and its abundance is osmolarity-and pH-dependent in renal epithelial cells HPLC reveals novel features of nucleoside and nucleobase homeostasis, nucleoside metabolism and nucleoside transport Diversity and sequence motifs of the bacterial SecA protein motor Solution NMR spectroscopy of membrane proteins Expression, purification, and functional reconstitution of (19)F-labeled cytochrome b5 in peptide nanodiscs for NMR studies where he serves as Director of NANUC, Canada's national NMR centre.
    keywords: acid; analysis; antibodies; binding; biological; biology; cells; challenges; complexes; copolymer; coworkers; dependent; detergent; domain; drug; dynamics; expression; field; free; function; gpcr; group; interactions; journal; key; lipid; maleic; membrane; memteins; methods; microfluidic; nanodiscs; native; new; nmr; nucleoside; peptide; pre; proof; protein; purification; receptor; recognition; residues; resolution; seca; sequence; signals; sma; sma(3:1; smalps; solubilization; specific; spectroscopy; states; structural; studies; styrene; targets; transporters
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        item: #45 of 68
          id: cord-300429-b0zev8zb
      author: Sobocińska, Justyna
       title: Protein Palmitoylation and Its Role in Bacterial and Viral Infections
        date: 2018-01-19
       words: 13448
      flesch: 31
     summary: + channels Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine Lysine fatty acylation promotes lysosomal targeting of TNF-α A Salmonella typhimurium effector protein SifA is modified by host cell prenylation and S-acylation machinery Geranylgeranylation but not GTP-loading of Rho GTPases determines T cell function Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity Local palmitoylation cycles define activity-regulated postsynaptic subdomains Analysis of S-acylation of proteins Chemical probes for the rapid detection of fatty-acylated proteins in mammalian cells Robust fluorescent detection of protein fatty-acylation with chemical reporters Large-scale profiling of protein palmitoylation in mammalian cells Assays of protein palmitoylation Visualization and identification of fatty acylated proteins using chemical reporters Nonradioactive analysis of dynamic protein palmitoylation Palmitoylome profiling reveals S-palmitoylation-dependent antiviral activity of IFITM3 Global profiling of dynamic protein palmitoylation Proteomic analysis of fatty-acylated proteins in mammalian cells with chemical reporters reveals S-acylation of histone H3 variants Global analysis of palmitoylated proteins in Toxoplasma gondii A single protein S-acyl transferase acts through diverse substrates to determine cryptococcal morphology, stress tolerance, and pathogenic outcome Purification of biotinylated proteins on streptavidin resin: a protocol for quantitative elution Comparative analysis of cleavable azobenzene-based affinity tags for bioorthogonal chemical proteomics Systems analysis of protein fatty acylation in herpes simplex virus-infected cells using chemical proteomics Single-cell in situ imaging of palmitoylation in fattyacylated proteins Method for cellular imaging of palmitoylated proteins with clickable probes and proximity ligation applied to Hedgehog, tubulin, and Ras Analysis of protein palmitoylation reveals a pervasive role in Plasmodium development and pathogenesis Global profiling of co-and post-translationally N-myristoylated proteomes in human cells Proteomic identification of palmitoylated proteins Palmitoylated proteins: purification and identification Site-specific analysis of protein S-acylation by resin-assisted capture Proteomic analysis of fatty-acylated proteins Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation Proteomic analysis of palmitoylated platelet proteins Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23 Quantitative analysis of the human T cell palmitome Global analysis of protein palmitoylation in African trypanosomes Identification of new palmitoylated proteins in Toxoplasma gondii Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation Role of S-palmitoylation by ZDHHC13 in mitochondrial function and metabolism in liver Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's Disease protein palmitoylation database. Recently, substantial progress in the understanding of protein palmitoylation was made possible by the development of methods allowing high-throughput analysis of cellular/tissue palmitoyl proteomes.
    keywords: acid; activation; activity; acylation; acyltransferases; addition; amino; analog; analysis; anthrax; antiviral; apparatus; approach; assembly; association; attachment; bacteria; binding; biotin; bond; budding; cells; cellular; chain; changes; chemical; chemistry; cholesterol; click; click chemistry; coa; complex; crucial; cysteine; cytoplasmic; data; dependent; detection; disease; domain; dynamic; effector; endoplasmic; envelope; enzymes; eukaryotic; evf; factor; family; fatty; fatty acids; fatty acylation; figure; functioning; fusion; global; glycine; glycoproteins; golgi; gram; group; high; hiv-1; host; host cells; host proteins; human; identification; ifitm3; immune; induced; infected; infection; inflammatory; influenza; innate; interactions; interest; intracellular; kinase; labeling; like; likely; linkage; lipid; lipoproteins; localization; long; lps; mammals; mass; mechanisms; membrane; membrane proteins; metabolic; method; modification; molecular; myristoylation; negative; new; non; palmitate; palmitic; palmitic acid; palmitoylation; pathogen; peripheral; plasma; plasma membrane; posttranslational; profiling; protein palmitoylation; proteins; proteomic; rafts; ras; raw264; reaction; receptor; replication; residues; responses; reticulum; role; salmonella; secretion; signaling; sites; specific; spectrometry; src; stability; stnfα; streptavidin; studies; study; subsequent; table; targeting; terminal; tetraspanin; thioester; thiol; tlr2; tlr4; tmtnfα; toll; toxin; transmembrane; type; viral; viral proteins; virulence; virus; viruses; zdhhc
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        item: #46 of 68
          id: cord-303238-us3dybue
      author: Kanjanahaluethai, Amornrat
       title: Membrane Topology of Murine Coronavirus Replicase Nonstructural Protein 3
        date: 2007-05-01
       words: 4847
      flesch: 41
     summary: The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity Phase separation of integral membrane proteins in Triton X-114 solution An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A Coronavirus genome structure and replication An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV Eukaryotic transientexpression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase Murine coronavirus membrane fusion is blocked by modification of thiols buried within the spike protein RNA replication of mouse hepatitis virus takes place at double-membrane vesicles Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity Intracellular functions of N-linked glycans The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein Identification of mouse hepatitis virus papain-like proteinase 2 activity Identification of the murine coronavirus MP1 cleavage site recognized by papain-like proteinase 2 The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B Open reading frame 1a-encoded subunits of the arterivirus replicase induce endoplasmic reticulum-derived double-membrane vesicles which carry the viral replication complex Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1ʺ-phosphate dephosphorylation by a conserved domain of nsP3 Coronavirus transcription: a perspective Processing of the coronavirus MHV-JHM polymerase polyprotein: identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Viral replicase gene products suffice for coronavirus discontinuous transcription Identification of a new human coronavirus Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Treatments with urea, NaCl or sodium carbonate, pH 11.5 have been shown to disrupt the association between peripheral, membrane-associated proteins, but such treatments do not disrupt integral membrane proteins (Bordier, 1981) .
    keywords: acid; activity; analysis; association; baker; buffer; cells; cen; cleavage; constructs; coronavirus; digestion; domain; egfp; endo; et al; expression; fig; glycosylation; helices; integral; kanjanahaluethai; kda; like; membrane; mhv; min; nsp3; nsp3tm; papain; plp2; polyprotein; processing; products; proteases; protein; proteinase; putative; region; replicase; replication; rna; sds; sequences; sites; studies; sufficient; topology; translation; transmembrane; viral
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        item: #47 of 68
          id: cord-309384-vlk8cebh
      author: Kolter, Thomas
       title: Ganglioside Biochemistry
        date: 2012-12-19
       words: 16942
      flesch: 31
     summary: I integral membrane protein of the endoplasmic reticulum Zebrafish and mouse α2,3-sialyltransferases responsible for synthesizing GM4 ganglioside Prevention of experimental allergic encephalomyelitis by ganglioside G(M4) Purification and characterization of UDP-glucose:ceramide glucosyltransferase from rat liver Golgi membranes Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis Oligomerization and topology of the Golgi 28 ISRN Biochemistry membrane protein glucosylceramide synthase Identification of active site residues in glucosylceramide synthase: a nucleotide-binding/catalytic motif conserved with processive β-glycosyltransferases Topology of glucosylceramide synthesis in Golgi membranes from porcine submaxillary glands Lactosylceramide is synthesized in the lumen of the Golgi apparatus MDR1 Pglycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine ABC lipid transporters: extruders, flippases, or flopless activators? Pre-and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis Reconstitution of glucosylceramide flip-flop across endoplasmic reticulum: implications for mechanism of glycosphingolipid biosynthesis Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide Mutation of βglucosidase 2 causes glycolipid storage disease and impaired male fertility Biosynthesis of glycolipids cDNA cloning and expression of human lactosylceramide synthase Isolation and characterization of extremely minor gangliosides, G(M1b) and G(D1α), in adult bovine brains as developmentally regulated antigens Enhanced insulin sensitivity in mice lacking ganglioside GM3 Tissue-specific expression of cseries gangliosides in the extraneural system Structural characterization of a novel cholinergic neuron-specific ganglioside in bovine brain Biosynthetic pathway for a new series of gangliosides, GT1aα and GQ1bα Biosynthesis of the major brain gangliosides GD1a and GT1b Glycosphingolipid functions: insights from engineered mouse models A mouse B16 melanoma mutant deficient in glycolipids Complex gangliosides are essential in spermatogenesis of mice: possible roles in the transport of testosterone Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice Attenuation of interleukin 2 signal in the spleen cells of complex gangliosidelacking mice CD4 and CD8 T cells require different membrane gangliosides for activation Mice lacking major brain gangliosides develop parkinsonism G(M1) ganglioside rescues substantia nigra pars compacta neurons and increases dopamine synthesis in residual nigrostriatal dopaminergic neurons in MPTP-treated mice GM1 specifically interacts with α-synuclein and inhibits fibrillation Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions Sphingolipid synthetic pathways are major regulators of lipid homeostasis Membranes in balance: mechanisms of sphingolipid homeostasis Regulation of ganglioside biosynthesis in the nervous system The cytoplasmic tail of GM3 synthase defines its subcellular localization, stability, and in vivo activity Multi-enzyme kinetic analysis of glycolipid biosynthesis Golgi localization of glycosyltransferases involved in ganglioside biosynthesis Regulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases The synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion Glycosyltransferase complexes improve glycolipid synthesis Physical and functional association of glycolipid N-acetylgalactosaminyl and galactosyl transferases in the Golgi apparatus Ganglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a Degradation of glycolipids Lysosomal degradation of membrane lipids Activator proteins and topology of lysosomal sphingolipid catabolism Regulation of apoptosis-associated lysosomal membrane permeabilization Recycling compartments and the internal vesicles of multivesicular bodies harbor most of the cholesterol found in the endocytic pathway Biological function of the cellular lipid BMP-BMP as a key activator for cholesterol sorting and membrane digestion Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin Separation and characterization of late endosomal membrane domains Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function Lysosomal membrane proteins: life between acid and neutral conditions Hoppe-Seyler's Zeitschrift für Physiologische Chemie The human G(M2) activator protein. Secondary storage of gangliosides GM2 and GM3 occurs also in Hurler disease [290] (mucopolysaccharidosis type I; α-Liduronidase deficiency).
    keywords: able; abundant; accumulation; acetyl; acid; activator; activator protein; active; activity; addition; adult; altered; amounts; analysis; animals; antibodies; antigen; apoptosis; apparatus; aspects; available; axon; bases; binding; biology; biosynthesis; blood; bmp; bovine; brain; brain gangliosides; cancer; carbohydrate; catalyzed; cell; cellular; ceramide; chain; changes; characterization; chemical; cholesterol; chromatography; clinical; complex; complexes; composition; content; core; crystal; cultured; defects; deficient; degradation; dependent; detergent; determination; development; different; differentiation; disease; disorders; domains; embryonic; enzyme; erythrocytes; essential; example; experiments; expression; extraction; factor; fatty; figure; form; formation; fraction; function; ga2; galactose; galactosidase; galcer; galnac; ganglioside biosynthesis; ganglioside gm1; gangliosides; gangliosidosis; gd1a; gd3; gene; general; glccer; glucose; glucosylceramide; glycan; glycoconjugates; glycolipids; glycosidases; glycosphingolipid; glycosylation; glycosyltransferases; gm1; gm2; gm2 activator; gm3; gm4; golgi; groups; growth; gsls; gt1b; head; hexosaminidase; higher; host; human; human brain; impaired; increase; infantile; inner; insulin; interaction; isolated; isolation; key; kidney; laccer; levels; life; like; linkage; lipid; liver; living; localization; luminal; lysosomal; lysosomes; major; mass; melanoma; membrane; metabolism; mice; model; modified; moiety; molecular; morquio; motor; mouse; murine; mutant; myelin; native; nervous; neu5gc; neuronal; neurons; neutral; new; niemann; nomenclature; normal; novel; number; oligosaccharides; organisms; pathway; patients; pattern; phase; phosphatidylcholine; plasma; presence; present; properties; protein; rafts; receptor; recognition; regulation; related; residues; role; sachs; sandhoff; saposin; secondary; separation; series; series gangliosides; serine; serum; short; sialic; sialic acid; sialidase; soluble; species; specific; specificity; spectrometry; sphingoid; sphingolipids; sphingosine; st3gal; starfish; step; storage; structure; studies; substrates; suitable; sulfate; sulfatide; surface; syndrome; synthase; system; tay; therapeutic; therapy; tissues; topology; total; transport; treatment; tumor; type; udp; variant; vesicles; vitro; vivo; water
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        item: #48 of 68
          id: cord-313599-5j19stye
      author: Wang, Xianfeng
       title: Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets
        date: 2013-05-26
       words: 25086
      flesch: 42
     summary: NFN membranes possess almost all the applications that traditional electrospun fibrous membranes have, and due to its much smaller fiber diameter and unique net-like structure, which bring ESN NFN membranes highly attractive to some special area, such as ultra-fine filters to intercept viruses, ultrasensitive sensors, as well as biomedicine. According to recent progress in controllable fabrication of polymer based NFN membranes, one can find that the RH plays an important role in formation of nano-nets.
    keywords: acid; addition; air; aligned; ambient; applications; applied; aqueous; area; attention; attractive; average; behavior; biomedical; carbon; cell; challenges; changes; characterization; charged; chemical; chemistry; chitosan; clothing; cnc; coated; collector; colorimetric; composite; composite membranes; composite nfn; concentration; conductivity; cone; content; controllable; conventional; core; coverage; crystal; current; decreased; density; detection; development; diameter; different; dimensional; ding; distance; distribution; droplets; effect; electric; electrode; electrospinning; electrospun; electrospun nanofibers; electrostatic; engineering; environmental; esn; esn nfn; esn process; example; fabrication; fascinating; fiber diameter; fibrous; fibrous membranes; field; fig; films; filters; filtration; force; formaldehyde; formation; formic; functional; fundamental; future; gas; gelatin; geometric; geometry; good; great; group; high; higher; humidity; hydrogen; images; important; improved; increase; influence; inorganic; instability; interest; interesting; investigation; ionic; jet; jets; kim; large; layer; lecithin; like; like nano; liquid; low; lower; main; major; mass; materials; mats; mechanical; mechanism; method; microbalance; minimal; molecules; morphology; mpeg; nacl; nano; nanocomposite; nanofibers; nanofibrous; nanofibrous membranes; nanomaterials; nanoparticles; nanostructures; nanowebs; nanowires; natural; nets; netting; network; new; nfn materials; nfn membranes; nfn morphology; nfn nanomaterials; nfn structure; novel; number; observed; organic; pa-6; pa-6 nfn; paa; pani; parameters; past; pei; peo; performance; permission; phase; physical; polyaniline; polymer; polymer solution; polymeric; polyurethane; pore; porosity; porous; possible; potential; prepared; problem; process; processing; properties; protective; pva; qcm; quartz; range; rapid; rate; recent; research; response; resultant; results; review; role; salt; scaffolds; scale; section; self; sem; sensing; sensitive; sensitivity; sensors; separation; significant; silk; single; size; small; smaller; soap; solution; solvent; specific; spider; steiner; strength; strong; structure; studies; study; surface; synthesis; system; table; technique; temperature; tensile; tension; time; tip; tissue; tma; tree; typical; ultrafine; ultrasensitive; ultrathin; uniform; unique; use; voltage; wang; water; web; wide; width; wt%; years; zno
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        item: #49 of 68
          id: cord-314402-kjzkk51t
      author: Zou, Guijin
       title: EML webinar overview: Simulation-assisted discovery of membrane targeting nanomedicine
        date: 2020-06-08
       words: 3203
      flesch: 31
     summary: In collaboration with a number of experimental groups, we show examples of simulation-assisted discovery of molecular agents capable of selectively penetrating and aggregating in bacterial lipid membranes, causing membrane permeability/rupture. Further study on different cell membranes demonstrates that the selectivity results from the presence of cholesterol in mammalian but not in bacterial membranes, as the cholesterol can condense the hydrophobic region of membrane, preventing the penetration of the molecular agents.
    keywords: active; adarotene; agents; aggregation; antibiotics; antiviral; aureus; bacterial; barrier; bilayers; bithionol; cd1530; cd437; cell; cholesterol; curvature; discovery; diseases; domain; dynamics; energy; fig; formation; free; growth; guvs; inclusion; infections; interface; intrinsic; lipid; mammalian; membrane; modelling; molecular; nanomedicine; new; penetration; pore; pore formation; potential; resistant; rupture; selectivity; simulation; size; webinar
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        item: #50 of 68
          id: cord-314604-w61sqy17
      author: Crone, Niek S. A.
       title: Modulation of Coiled-Coil Binding Strength and Fusogenicity through Peptide Stapling
        date: 2020-02-14
       words: 6645
      flesch: 43
     summary: In this study, a library of nine stapled peptides was prepared by modifying peptide K via cysteine alkylation. The effectiveness of E/ K-based membrane fusion is partially attributed to the membrane interactions of peptide K, which are theorized to induce membrane curvature and therefore accelerate the transition from membrane docking to hemifusion.
    keywords: acid; alpha; amino; binding; changes; coil; comparable; component; concentration; content; cross; cysteine; dependent; design; different; dissociation; dmf; effect; entropic; entropy; equiv; experiments; figure; fluorescence; formation; fusion; fusogenicity; gw-3; helical; helicity; heterodimeric; hydrocarbon; increase; interactions; interface; itc; largest; linker; linking; lipid; liposomes; membrane; membrane fusion; meta; mixing; observed; ortho; peptide; peptide k; peptide variants; protein; reduced; resin; single; size; snare; stability; stapled; stapled peptide; stapling; strategies; strength; structure; system; technique; temperature; terminal; titration; variants; water; xylene
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        item: #51 of 68
          id: cord-317430-uvx8si42
      author: Chen, Yaping
       title: Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions
        date: 2020-08-26
       words: 11493
      flesch: 33
     summary: Here, tuneable cell–VNS interfacial interactions are probed and assessed, highlighting the use of 1D‐VNS in immunomodulation, and intracellular delivery into immune cells—both crucial in fundamental and translational biomedical research. Significant work has recently been done on immune cells-the central players in disease fighting that hold great clinical potential.
    keywords: acad; access; acs; actin; activation; adaptive; adherent; adhesion; antibodies; antigen; applied; arrays; authors; b cells; bar; biochemical; biomedical; biophysical; cancer; cargoes; cd4; cell membrane; cells; cellular; clathrin; clinical; cll; complex; control; conventional; copyright; ctl; cues; curvature; cytoskeleton; dcs; deformation; delivery; diameter; different; differentiation; direct; domain; dynamic; effective; effects; efficiency; electroporation; endocytic; endocytosis; engineering; enhanced; example; expression; figure; flat; forces; functions; genes; genetic; geometry; gfp; green; high; higher; images; imaging; immune; immune cells; immune responses; immunity; immunotherapy; important; induced; inflammatory; innate; interactions; interface; intracellular; key; likely; local; lymphocytes; materials; mechanical; mechanisms; membrane; methods; modulation; molecular; multiple; nanocones; nanopillars; nanoscale; natl; nature; nes; nuclear; particles; particular; pathways; pdms; penetration; permission; physical; pillars; plasma; plasmids; platforms; potential; primary; processes; progress; proteins; protrusions; range; rapid; recent; receptor; red; regulatory; release; research; responses; results; role; scale; schematic; sem; sharp; signaling; significant; sinws; sirnas; specific; spiky; studies; study; substrates; surface; suspension; system; t cells; target; therapeutic; time; transfection; tumor; types; use; viability; viral; vivo; vns; wnt; www.advancedsciencenews.com; www.advmat.de
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        item: #52 of 68
          id: cord-319754-5isw53wl
      author: Balgoma, David
       title: Lipidomics Issues on Human Positive ssRNA Virus Infection: An Update
        date: 2020-08-31
       words: 12122
      flesch: 37
     summary: This energetic burden has been demonstrated to be afforded by the cooperation of three fusion peptides in influenza virus membrane fusion [23] , whereas two adjacent trimers of the fusion protein are required in West Nile virus [24] . This process implies viral envelope and host cell membrane fusion, for which an energetically cost-effective barrier must be overcome.
    keywords: acid; actin; activation; activity; antiviral; attachment; aup1; authors; autophagy; bilayer; binding; c virus; caveolae; cell; cell lipid; cell membrane; ceramide; changes; cholesterol; clathrin; composition; content; coronavirus; cov; covid-19; curvature; cycle; dehydration; denv; dependent; different; direct; diverse; dmvs; double; early; effect; efficient; endocytic; endocytosis; endosomes; entry; enveloped; essential; evidence; factor; family; fatty; figure; formation; function; fusion peptide; hcv; hemifusion; hepatitis; high; host; host cell; host membrane; induced; infected; infection; influenza; influenza virus; inhibition; inner; interaction; interferon; internalization; known; leaflet; likely; lipid; lipid composition; lipid metabolism; lipid rafts; liposomes; loop; mechanisms; membrane; membrane fusion; membrane lipid; metabolism; necessary; negative; non; outer; particular; pathway; peptide; phase; phospholipid; pip2; place; plasma; pore; positive; process; protein; rafts; recent; receptor; regulation; related; relevant; replication; research; response; results; rna; role; sars; signaling; specific; spike; stage; stalk; step; studies; study; synthesis; target; type; vesicles; viral; viral fusion; viral membrane; virus; virus entry; virus infection; virus proteins; virus replication; viruses
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        item: #53 of 68
          id: cord-323319-u5hfkjv8
      author: Xu, Mengchang
       title: Analysis of the biodegradation performance and biofouling in a halophilic MBBR-MBR to improve the treatment of disinfected saline wastewater
        date: 2020-10-22
       words: 1238
      flesch: 15
     summary: Safety And Hygienic Standard For Disinfection By Sodium 345 Hypochlorite Generator Water and Wastewater Monitoring Methods 349 Membrane fouling reduction and improvement of sludge characteristics by bioflocculant addition in 350 submerged membrane bioreactor Water Sprinkler Transforms into Disinfection Vehicle Long-term operation of 354 submerged membrane bioreactor (MBR) for the treatment of synthetic wastewater containing styrene 355 as volatile organic compound (VOC): Effect of hydraulic retention time (HRT) Role and levels of real-time monitoring for successful anti-fouling strategies -an 358 overview Influence of elevated pH shocks on the performance 360 of a submerged anaerobic membrane bioreactor Effects Of High Sodium-Chloride Concentrations on Activated-362 Sludge Treatment Can 364 membrane bioreactor be a smart option for water treatment Simultaneous removal of organic matter and salt ions from saline wastewater 366 in bioelectrochemical systems Response Of Biological Waste Treatment Systems To Changes In Salt 368 Concentrations The effect of salt on the performance and 370 characteristics of a combined anaerobic-aerobic biological process for the treatment of synthetic 371 wastewaters containing Reactive Black 5 Analytical methods for soluble microbial products (SMP) and 373 extracellular polymers (ECP) in wastewater treatment systems: A review Biofouling behavior and performance of forward 375 osmosis membranes with bioinspired surface modification in osmotic membrane bioreactor Soluble microbial products in membrane bioreactor operation: 378 Behaviors, characteristics, and fouling potential A critical 380 review of extracellular polymeric substances (EPSs) in membrane bioreactors: Characteristics, roles in 381 membrane fouling and control strategies Observations Of Fouling Biofilm Formation Applicability of an integrated moving sponge biocarrier-osmotic membrane bioreactor MD system 386 for saline wastewater treatment using highly salt-tolerant microorganisms Effect of high salinity on activated sludge characteristics and 389 membrane permeability in an immersed membrane bioreactor Effect of high salinity on activated sludge characteristics and 392 membrane permeability in an immersed membrane bioreactor Novel external extractive membrane 395 bioreactor (EMBR) using electrospun polydimethylsiloxane/polymethyl methacrylate membrane for 396 phenol-laden saline wastewater Desalination and reuse of high-salinity shale gas produced water: drivers, technologies, and future 399 directions Protein, cell and bacterial fouling resistance of 401 polypeptoid-modified surfaces: effect of side-chain chemistry Cultivation of activated sludge using sea 403 mud as seed to treat industrial phenolic wastewater with high salinity Real-time monitoring of biofoulants in a membrane 406 bioreactor during saline wastewater treatment for anti-fouling strategies Behaviour of fouling-related components in an enhanced membrane bioreactor 409 using marine activated sludge A critical review on saline wastewater treatment by 411 membrane bioreactor (MBR) from a microbial perspective Membrane fouling from 413 ammonia recovery analyzed by ATR-FTIR imaging Review on the state of 415 science on membrane bioreactors for municipal wastewater treatment Concentration 417 and detection of SARS coronavirus in sewage from Xiao Tang Shan hospital and the 309th Hospital of the 418 Chinese People's Liberation Army Impact of Temperature Seasonal Change on Sludge Characteristics Understanding ultrafiltration 423 membrane fouling by soluble microbial product and effluent organic matter using fluorescence 424 excitation-emission matrix coupled with parallel factor analysis Removal and degradation 426 mechanisms of sulfonamide antibiotics in a new integrated aerobic submerged membrane bioreactor 427 system Probing the radical chemistry in UV/persulfate-based 429 saline wastewater treatment: Kinetics modeling and byproducts identification The synthetic NaClO-containing wastewaters have been effectively treated in a saline MBBR-MBR (moving bed biofilm reactor & membrane bioreactor) system containing marine microorganisms.
    keywords: antifouling; biofoulants; biofouling; bioreactor; characteristics; concentration; day; effect; fouling; high; membrane; microbial; monitoring; naclo; novel; performance; real; saline; salinity; sludge; strategy; system; tmp; treatment; wastewater
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        item: #54 of 68
          id: cord-325712-9kbnyqt3
      author: Nathan, Lakshmi
       title: Single Virion Tracking Microscopy for the Study of Virus Entry Processes in Live Cells and Biomimetic Platforms
        date: 2019-07-18
       words: 10241
      flesch: 37
     summary: In combination with a high throughput approach, these conditions (left) can be evaluated to provide new insight into virus fusion. elife 4:e11009 Stochastic fusion simulations and experiments suggest passive and active roles of hemagglutinin during membrane fusion Viral fusion efficacy of specific H3N2 influenza virus reassortant combinations at single-particle level Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level Cell fusion by Semliki forest, influenza, and vesicular stomatitis viruses
    keywords: ability; able; actin; adenovirus; analysis; approach; assays; behavior; bilayers; binding; biomimetic; bulk; capsid; cargo; caveolin; cell; cellular; clathrin; common; components; composition; conditions; configuration; control; cytoskeletal; cytosol; data; dependent; different; diffusion; dimensional; dyes; early; endocytosis; endosomal; endosomes; ensemble; entry; enveloped; environment; events; example; experiments; exposure; fluorescence; fusion; fusion proteins; genome; glass; hemifusion; high; hiv; hiv-1; host; image; imaging; individual; infection; influenza; influenza virus; information; interactions; intracellular; kinetics; labeling; lag; like; lipid; liposomes; live; live cell; measurements; mechanisms; membrane; membrane fusion; methods; microscopy; mobility; motion; movement; non; nuclear; particle; pathway; planar; plasma; platforms; pore; processes; proteins; rate; receptor; release; resolution; single; single virion; specific; spread; steps; studies; study; supported; surface; target; techniques; time; tirf; tracking; transport; trigger; type; uptake; vesicular; viral; viral fusion; virion; virion tracking; virus; virus entry; viruses; vitro
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        item: #55 of 68
          id: cord-325915-dw989txm
      author: Wolf, Michael W
       title: Downstream processing of cell culture-derived virus particles
        date: 2014-01-09
       words: 11875
      flesch: 28
     summary: The emerging generation of chromatography tools for virus purification Outlines the advantages of monoliths as chromatography tools for virus purification Purification of cell culturederived modified vaccinia ankara virus by pseudo-affinity membrane adsorbers and hydrophobic interaction chromatography Monoliths emerge as key purification methodology Direct capture of influenza A virus from cell culture supernatant with Sartobind anion-exchange membrane adsorbers Engineering adeno-associated virus for one-step purification via immobilized metal affinity chromatography Purification of cell culture-derived influenza virus A/Puerto Rico/8/34 by membrane-based immobilized metal affinity chromatography Sulfated membrane adsorbers for economic pseudo-affinity capture of influenza virus particles Exploiting heparin-binding properties of MoMLV-based retroviral vectors for affinity chromatography Purification of porcine reproductive and respiratory syndrome virus from cell culture using ultrafiltration and heparin affinity chromatography Removal of poliovirus type 1 from a protein mixture using an immunoaffinity chromatography column Affinity capture of a biotinylated retrovirus on macroporous monolithic adsorbents: towards a rapid single-step purification process Concanavalin A affinity chromatography for efficient baculovirus purification Lectin-affinity chromatography for downstream processing of MDCK cell culture derived human influenza A viruses One-step selection of Vaccinia virusbinding DNA aptamers by MonoLEX Chromatographic purification of virus particles Tagging retrovirus vectors with a metal binding peptide and one-step purification by immobilized metal affinity chromatography Protein adsorption dissociation constants in various types of biochromatography Large-scale processing of recombinant retroviruses for gene therapy Capture of cell culture-derived influenza virus by lectins: strain independent, but host cell dependent Development and scale up of preparative HIC for the purification of a recombinant therapeutic protein High-throughput screening of chromatographic separations: II. However, as discussed by the authors, the acidic isoelectric point of influenza virus particles (Table 2 ) may have resulted in co-precipitation of virus particles with cationic polymers [28] , and therefore product losses.
    keywords: aav; acids; active; addition; adenovirus; adsorbers; adsorption; aec; affinity; anion; application; applied; available; beads; biological; buffer; capacities; capture; cell; cellulose; centrifugation; characterization; chromatography; clinical; column; combination; concentration; concepts; conditions; contaminants; continuous; cultivation; culture; current; density; design; development; different; dna; downstream; dsp; dynamic; efficient; elution; encephalitis; examples; exchange; exclusion; fiber; filtration; final; flat; flow; flux; free; gene; gene therapy; gradient; heparin; hepatitis; hic; high; hollow; host; human; hydrophobic; iec; immobilized; immunogenicity; important; improved; individual; infectious; influenza; influenza virus; interactions; ionic; isoelectric; kda; large; leukemia; levels; ligands; losses; majority; manufacturing; material; matrices; matrix; media; medium; membrane; membrane adsorbers; methods; mode; molecular; monoliths; murine; new; nucleic; number; operations; optimization; overall; overview; particles; particular; performance; permeate; phase; pore; potential; precipitation; process; processes; processing; production; products; properties; proteins; purification; purification process; purity; range; rates; recombinant; recoveries; removal; resins; results; retroviral; retroviridae; review; scale; screening; sec; separation; sheet; size; small; specific; stationary; step; strength; structure; successful; sucrose; surface; systems; table; tangential; target; techniques; technology; therapy; therapy vectors; throughput; trains; type; ultrafiltration; unit; usa; vaccines; vaccinia; vectors; viral; viral vectors; virus; virus particles; virus purification; viruses; volume; yields
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        item: #56 of 68
          id: cord-327765-qdbgkm53
      author: Kinnun, Jacob J.
       title: Lateral Heterogeneity and Domain Formation in Cellular Membranes
        date: 2020-09-15
       words: 5433
      flesch: 36
     summary: Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes Partitioning of lipidmodified monomeric GFPs into membrane microdomains of live cells Jessup, W. Visualizing lipid structure and raft domains in living cells with two-photon microscopy Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles Elucidating membrane structure and protein behavior using giant plasma membrane vesicles Helicobacter pylori lipids can form ordered membrane domains (rafts) Direct observation of the nanoscale dynamics of membrane lipids in a living cell Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts Dynamic reorganization and correlation among lipid raft components Lipid rafts: contentious only from simplistic standpoints If we consider two domains with thickness difference, δ, and an average thickness, h 0 , the line tension at the domain boundary can be written as: A feature of increasing importance is the packing defects between membrane lipids.
    keywords: acids; acyl; bilayer; biological; cells; chains; cholesterol; composition; coupling; critical; curvature; density; different; disordered; domain; domain formation; dynamics; energy; fatty; field; fig; fluctuations; fluid; formation; free; heterogeneity; high; interaction; lateral; leaflets; length; line; lipid; liquid; living; mechanism; membrane; microemulsion; mixtures; model; modulated; molecular; nanoscopic; neutron; nmr; non; note; order; organization; parameter; phase; phosphatidylcholine; plasma; polyunsaturated; potential; properties; proteins; raft; range; registration; research; result; rigid; rigidity; scattering; separation; size; specific; sphere; spherical; sphingomyelin; structure; study; surface; temperatures; tension; term; thickness; transition; vesicles
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        item: #57 of 68
          id: cord-329448-kxxy60x9
      author: Kumari, Sudha
       title: Endocytosis unplugged: multiple ways to enter the cell
        date: 2010-02-02
       words: 11551
      flesch: 27
     summary: It is likely that there are many different biochemical and physical principles behind the formation of vesicles in cell membrane. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe Molecular mechanisms of clathrinindependent endocytosis Evolutionary analysis and molecular dissection of caveola biogenesis CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts Cholesterol depletion activates rapid internalization of submicron-sized acetylcholine receptor domains at the cell membrane Pathways of clathrin-independent endocytosis Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity Magnetosomes are cell membrane invaginations organized by the actin-like protein MamK Reconstructing the evolution of the endocytic system: insights from genomics and molecular cell biology Protein and lipid requirements for endocytosis A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15 Regulators of yeast endocytosis identified by systematic quantitative analysis Endocytosis in the plant-pathogenic fungus Ustilago maydis Kinesin from the plant pathogenic fungus Ustilago maydis is involved in vacuole formation and cytoplasmic migration Aspergillus nidulans ArfB plays a role in endocytosis and polarized growth Role for Arf3p in development of polarity, but not endocytosis, in Saccharomyces cerevisiae Endocytosis, endosome trafficking, and the regulation of Drosophila development Macromolecular uptake in Drosophila pericardial cells requires rudhira function Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic Receptor-mediated endocytosis in plants is energetically possible Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin Molecular dissection of endosomal compartments in plants Actin-dependent fluid-phase endocytosis in inner cortex cells of maize root apices Sucrose-inducible endocytosis as a mechanism for nutrient uptake in heterotrophic plant cells Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold Clathrin-mediated constitutive endocytosis of PIN auxin efflux carriers in Arabidopsis Phylogeny of endocytic components yields insight into the process of nonendosymbiotic organelle evolution
    keywords: actin; activation; activity; adaptor; addition; analysis; aps; arf6; assembly; associated; binding; budding; cargo; cargoes; caveolae; caveolin; cdc42; cell; cellular; cholesterol; clathrin; clear; coat; coated; complex; conserved; cup; curvature; dependent; different; direct; distinct; diversity; domain; drosophila; dynamics; dynamin; early; endocytic; endocytic pathway; endocytosis; endosomal; endosomes; entry; epithelial; evidence; example; factor; family; fcr; figure; fission; flotillin-1; flotillins; fluid; formation; function; geec; genes; genetic; gpi; graf1; growth; gtpases; human; independent endocytosis; induced; inhibition; internalization; internalized; invaginations; isoforms; kinase; large; like; lines; lipid; live; loss; machinery; macropinocytosis; macropinosomes; mammalian; means; mechanism; membrane; modes; molecular; molecules; multiple; mutants; necessary; non; novel; number; operation; overexpression; particles; pathogens; pathway; phagocytic; phagocytosis; phagosome; phase; pinching; pit; plant; polymerization; possible; primary; process; processes; proteins; rac1; recent; receptor; recruitment; recycling; regulated; regulation; regulators; remodeling; rho; role; route; scission; screen; sensitive; shibire; signaling; site; size; small; sorting; specific; structures; studies; study; surface; system; time; toxin; trafficking; type; understanding; uptake; variety; vesicle; virus; wide; yeast
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        item: #58 of 68
          id: cord-330110-pamxy4av
      author: Teissier, Elodie
       title: Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol
        date: 2011-01-25
       words: 9290
      flesch: 43
     summary: This could result in conformational rearrangements and, in the context of Arb fusion inhibition, aromatic residues might consequently become more or less accessible to Arb molecules present in their vicinity. Arb concentration in solution was measured at 280 nm in the supernatant (Arb extinction coefficient = 9510 M 21 .cm 21 ).
    keywords: absence; acidic; activity; addition; affinity; analyte; antiviral; apparent; arb; arbidol; aromatic; association; bilayer; binding; broad; c virus; cell; chip; chol; concentrations; conformational; data; dependent; depth; derivatives; dmpc; effect; entry; envelope; environment; equilibrium; experiments; figure; final; flow; fluorescence; function; fusion; genotypes; glycoprotein; group; hcv; hcvpp; hepatitis; ic50; immersion; indole; infection; infectivity; influenza; inhibition; inhibitory; inhibits; interaction; interface; key; lipid; liposomes; low; mechanism; membrane; membrane fusion; micelles; micromolar; min; mixing; model; molar; molecules; nmr; ns4a; observed; order; paramagnetic; peptides; phospholipid; presence; present; properties; protein; protons; pseudoparticles; range; region; relaxation; residues; resonance; section; sensor; signal; solution; spectra; spectroscopy; spectrum; structure; studies; surface; table; target; time; toe; trp; tryptophan; values; viral; virus; viruses; water
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        item: #59 of 68
          id: cord-333757-h12aozg2
      author: Modis, Yorgo
       title: Class II Fusion Proteins
        date: 2013-07-10
       words: 6796
      flesch: 44
     summary: The structures show that, despite the absence of similarities in the protein folds of the two classes, fusion proteins from both classes use the same physical principles and general topology to drive membrane fusion. Although class II fusion proteins are genetically and structurally unrelated to class I fusion proteins, they use the same physical principles and topology as other fusion proteins to drive membrane fusion.
    keywords: alphaviruses; anchor; bilayer; binding; cell; cell membrane; cellular; cholesterol; class; class ii; conformation; contacts; core; crystal; dengue; dengue virus; domain; domain ii; drive; encephalitis; energy; entry; envelope; envelope protein; fig; flaviviruses; forest; fusion; fusion anchor; fusion loop; fusion proteins; glycoprotein; gp41; hemagglutinin; hemifusion; hinge; hiv; host; hydrophobic; ii fusion; iii; influenza; insertion; loop; mature; mechanism; membrane; membrane fusion; mutations; peptide; pocket; postfusion; prefusion; protein; rearrangement; receptor; region; residues; semliki; stem; structure; surface; terminal; transition; transmembrane; trimer; viral; viral membrane; virus; virus fusion; viruses
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        item: #60 of 68
          id: cord-336929-2rnkotqy
      author: Vieira, Flávia Sarmento
       title: Host‐cell lipid rafts: a safe door for micro‐organisms?
        date: 2012-01-03
       words: 9931
      flesch: 29
     summary: However, in vivo, TCR does not constitutively reside in membrane lipid rafts. C1845 promotes cytoskeletal F-actin rearrangements in cultured human intestinal INT407 cells Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae ATP acts as an agonist to promote stimulus-induced secretion of IL-1b and IL-18 in human blood Hide, shield and strike back: how HIV-infected cells avoid immune eradication Lipid rafts and pseudotyping Membrane lipid organization is critical for human neutrophil polarization Lipid rafts: bringing order to chaos The challenge of lipid rafts H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton Association of MHC class II-peptide complexes with plasma membrane lipid microdomains The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4 + T cells Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes Cholesterol is required for Leishmania donovani infection: implications in leishmaniasis Use of Forster's resonance energy transfer microscopy to study lipid rafts Human immunodeficiency virus and host cell lipids.
    keywords: actin; activation; activity; acts; addition; adhesion; anderson; antigen; assembly; associated; association; atp; bacteria; binding; blood; brucella; budding; caveolae; caveolin; cell; cell membrane; cellular; ceramide; chazal; cholesterol; class; components; dependent; depletion; different; disruption; donovani; dynamic; efficient; endocytosis; entry; enveloped; epithelial; erythrocyte; et al; evidence; example; family; formation; function; fusion; gerlier; glycoproteins; gondii; hiv; host; host cell; human; immune; important; infected; infection; influenza; interaction; internalization; intracellular; invasion; involvement; kinases; leishmania; leishmaniasis; like; lipid; lipid rafts; lps; luo; machinery; macrophages; mañes; mañes et; mechanisms; members; membrane; membrane rafts; method; mhc; microdomains; microscopy; model; modulation; molecular; molecules; new; non; p2x; parasites; parasitophorous; particles; pathogens; pathway; plasma; plasma membrane; platforms; presentation; process; proteins; rafts; receptor; regions; regulation; related; response; rich; role; secretion; sensitive; signalling; small; specific; sphingolipid; stimulation; structures; studies; study; surface; survival; sv40; system; target; time; tlrs; toxin; toxoplasma; transduction; transport; triantafilou; types; tyrosine; vacuole; van; viral; virus; viruses
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        item: #61 of 68
          id: cord-338827-1moy43hr
      author: Stillwell, William
       title: Membrane Transport
        date: 2016-07-15
       words: 8279
      flesch: 56
     summary: Cell membrane Cell membrane FIGURE 19.11 Aquaporin. The basic types of membrane transport, simple passive diffusion, facilitated diffusion (by channels and carriers) and active transport are summarized in Fig.
    keywords: -atpase; acid; action; active; active transport; adjacent; atp; basic; bilayer; biological; carriers; cell; channel; chapter; concentration; cross; crown; diffusion; dnp; electrical; electrochemical; endocytosis; energy; enzyme; ethers; example; facilitated; fig; figure; form; free; gap; glucose; gradient; high; hydrophobic; important; inside; intracellular; ionophore; junctions; k þ; known; lactose; large; left; like; lipid; mechanism; membrane; membrane transport; molecular; molecules; movement; na þ; nobel; number; nystatin; osmotic; ouabain; outside; passive; passive diffusion; permeability; phagocytosis; pinocytosis; plasma; plasma membrane; potassium; potential; primary; prize; process; proteins; proton; results; right; semipermeable; simple; single; size; small; soluble; solute; specific; state; structure; surface; system; transmembrane; transport; types; uptake; use; valinomycin; vesicles; water; work
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        item: #62 of 68
          id: cord-339172-210dwhgj
      author: Knoops, Kèvin
       title: SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum
        date: 2008-09-16
       words: 9958
      flesch: 39
     summary: For MHV, based on IF microscopy studies using the nsp13 helicase and viral membrane (M) protein as markers for RTCs and virus assembly sites [21] , respectively, such a connection was previously proposed [54] , but could not be corroborated in our studies using the same protein markers in SARS-CoV-infected cells [28] . Alternatively, the conspicuous absence of ribosomes from DMV inner membranes lends some credibility to a scenario involving a preformed inner vesicle derived from another membrane source.
    keywords: acute; alterations; analysis; antibodies; antisera; axis; budding; cells; cellular; compartments; complex; complexes; connected; connections; continuous; coronavirus; cov; cytoplasm; cytosol; data; diameter; different; dmv inner; dmvs; double; dsrna; early; electron; fact; figure; formation; genome; hepatitis; host; iem; images; immunolabeling; induced; infected; infection; inner; interior; intracellular; labeling; large; like; likely; membrane; mhv; microscopy; modified; mouse; multiple; negative; network; nonstructural; nsp3; nsp5; nsp8; nsps; outer; outer membrane; p.i; particular; positive; present; processing; protein; recent; replicase; replication; respiratory; reticulovesicular; rna; rna synthesis; rtc; samples; sars; sections; severe; similar; single; site; small; specific; stages; strand; structures; studies; subunits; syndrome; synthesis; tilt; tomograms; tomography; transcription; type; ultrastructural; vero; vesicles; video; viral; viral rna; virus; viruses; vps; þrna
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        item: #63 of 68
          id: cord-341129-eo0vjcmk
      author: Kielian, Margaret
       title: Virus membrane-fusion proteins: more than one way to make a hairpin
        date: 2006
       words: 6993
      flesch: 35
     summary: Membrane fusion Intracellular and viral membrane fusion: a uniting mechanism The many mechanisms of viral membrane fusion proteins How viruses enter animal cells Viral entry On the entry of Semliki Forest virus into BHK-21 cells SFV infection in CHO cells: cell-type specific restrictions to productive virus entry at the cell surface Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion Structures and mechanisms in flavivirus fusion HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor Mechanisms of viral membrane fusion and its inhibition Paramyxovirus fusion: a hypothesis for changes Retroviral entry mediated by receptor priming and low pH triggering of an envelope glycoprotein Sequential roles of receptor binding and low pH in forming prehairpin and hairpin conformations of a retroviral envelope glycoprotein Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection A spring-loaded mechanism for the conformational change of influenza hemagglutinin Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin Mechanism of membrane fusion by viral envelope proteins Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes Influenza hemagglutinin is spring-loaded by a metastable native conformation Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution First structure of a viral membrane-fusion protein First structure of the 'post-fusion' conformation of a viral membrane-fusion protein Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion First demonstration that class I fusion is driven by hairpin formation Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers Synchronized activation and refolding of influenza hemagglutinin in multimeric fusion machines Influenza hemagglutinins outside of the contact zone are necessary for fusion pore expansion The entry of entry inhibitors: a fusion of science and medicine A synthetic peptide from HIV-1 gp41 is a potent inhibitor of virus-mediated cell-cell fusion Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusion Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus Structurebased identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity The fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH Prefusion structure of alphavirus E1 protein, showing unexpected similarity to flavivirus E protein, leading to concept of 'class II' membrane-fusion proteins Membrane fusion process of Semliki Forest virus II: cleavage-dependent reorganization of the spike protein complex controls virus entry Furin processing and proteolytic activation of Semliki Forest virus Proteolytic activation of tick-borne encephalitis virus by furin Cell-associated West Nile flavivirus is covered with E+pre-M protein heterodimers which are destroyed and reorganized by proteolytic cleavage during virus release Budding of alphaviruses A structural perspective of the flavivirus life cycle Cryo-electron microscopy reveals the functional organization of an enveloped virus, Semliki forest virus Placement of the structural proteins in sindbis virus Structures of immature flavivirus particles First description of mature flavivirus surface organization, showing the striking herringbone arrangement of fusion protein homodimers Visualization of membrane protein domains by cryo-electron microscopy of dengue virus Structure of West Nile virus Crystal structure of the Semliki Forest virus envelope protein E1 in its monomeric conformation: identification of determinants for icosahedral particle formation The envelope glycoprotein from tickborne encephalitis virus at 2 Å resolution A ligand-binding pocket in the dengue virus envelope glycoprotein Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein Conformational changes of the flavivirus E glycoprotein Membrane fusion process of Semliki Forest virus I: low pH-induced rearrangement in spike protein quaternary structure precedes virus penetration into cells Membrane fusion of Semliki Forest virus involves homotrimers of the fusion protein References 56 and 57 comprise the first reports of homotrimer formation for a class II fusion protein Oligomeric rearrangement of tickborne encephatitis virus envelope proteins induced by an acidic pH Formation and characterization of the trimeric form of the fusion protein of Semliki Forest virus Role of metastability and acidic pH in membrane fusion by tick-borne encephalitis virus Mechanisms of mutations inhibiting fusion and infection by Semliki Forest virus Mutational evidence for an internal fusion peptide in flavivirus envelope protein E The heterodimeric association between the membrane proteins of Semliki Forest virus changes its sensitivity to low pH during virus maturation Membrane and protein interactions of a soluble form of the Semliki Forest virus fusion protein First demonstration that class II ectodomain can form homotrimer when treated at low pH in presence of target membrane Membrane interactions of the tick-borne encephalitis virus fusion protein E at low pH Purification and crystallization reveal two types of interactions of the fusion protein homotrimer of Semliki Forest virus Characterization of a membraneassociated trimeric low-pH-induced form of the class II viral fusion protein E from tick-borne encephalitis virus and its crystallization Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus Structure of the dengue virus envelope protein after membrane fusion References 68, 69 and 70 are the first reports of low-pH-induced homotrimer structure of class II fusion proteins Multistep regulation of membrane insertion of the fusion peptide of Semliki Forest virus T20 blocks the interaction of the C-terminal segment of the fusion protein with the groove of the central coiled coil (FIG. 4) , and blocks virus fusion and infection.
    keywords: alphavirus; amino; binding; cell; cell fusion; changes; cholesterol; class; class ii; conformational; dependent; different; domain; ectodomain; electron; encephalitis; entry; envelope; example; fig; flavivirus; fold; forest; forest virus; fusion; fusion loop; fusion peptide; fusion proteins; glycoprotein; ha2; hairpin; helix; hemagglutinin; homotrimer; ii fusion; important; induced; infection; influenza; insertion; interactions; lipid; loop; low; mechanism; membrane; membrane fusion; membrane insertion; microscopy; non; overall; peptide; proteins; reaction; receptor; region; role; semliki; sfv; single; site; small; specific; structure; studies; surface; target; target membrane; terminal; terminus; trimer; trimeric; type; viral; virus; virus fusion; virus membrane; viruses
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        item: #64 of 68
          id: cord-341378-pw60qx7c
      author: Armstrong, John
       title: Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus
        date: 1984
       words: 1583
      flesch: 47
     summary: First, in contrast to the majority of membrane proteins, El is known to lack a cleaved 'signal peptide' 9 : the N-terminal region of the sequence contains no good candidate for a cleava3e site 34 • Second, the N-terminal region bears 0-linked sugars 5 ' 36 , which, uniquely among viral proteins so far studied, are the only known post-translational modification to El. Each of the compartments of this transport pathway carries out particular metabolic functions(5–8), and therefore presumably contains a distinct complement of membrane proteins.
    keywords: a59; analysis; cell; endoplasmic; features; gene; glycoprotein; mechanisms; membrane; membrane proteins; mhv; model; mrna; particular; protein; region; residues; reticulum; rna; sequence; study; surface; transport; viral
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        item: #65 of 68
          id: cord-346446-i7gpxcyo
      author: Zhang, Jianguo
       title: Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine
        date: 2020-10-22
       words: 6099
      flesch: 27
     summary: [30, 39] . addition of TCA cycle metabolites into the cell culture might not promote PMLA production [11] . By depleting the nitrogen supply or augmenting the carbon/nitrogen ratio in the cell medium, PMLA bioproduction is significantly enhanced per unit of cell mass because nitrogen starvation upregulates the expression of key enzymes in PMLA biosynthetic pathways, uncoupling cell growth from PMLA production
    keywords: 100−x; acid; acidic; activity; addition; amp; aureobasidium; backbone; beta; binding; bioproduction; biosynthesis; blood; brain; cancer; carbon; carboxylic; carrier; cas9; cell; cellular; chain; charge; complexes; crispr; culture; cycle; cytoplasm; degradation; delivery; dna; drug; efficient; enhanced; enzyme; ester; exogenous; figure; form; formation; gene; glioblastoma; glyoxylate; groups; high; hydrolases; hydrophobic; injection; interactions; ionic; key; life; like; lipid; low; malate; malic; malic acid; malyl; mass; membrane; microorganisms; mitochondrial; model; mol; molar; molecular; nitrogen; novel; nuclear; oxaloacetate; oxidative; pathway; peptide; physarum; pmla; poly(beta; poly(l; polycephalum; polymalic; polymalic acid; polymer; potential; production; proteins; pullulans; pyruvate; scale; specific; surface; synthetase; synthetic; tca; treatment; tumor; unit; vivo; water; yeast
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        item: #66 of 68
          id: cord-349341-ap5n6ijl
      author: Kopek, Benjamin G
       title: Three-Dimensional Analysis of a Viral RNA Replication Complex Reveals a Virus-Induced Mini-Organelle
        date: 2007-08-14
       words: 8597
      flesch: 38
     summary: BMV and FHV differ in many important respects including that BMV encodes a much larger complement of RNA replication proteins [15, 19] . A revealed by fluorescence resonance energy transfer Colloidal gold: Principles, methods and applications From proteomic inventory to architecture Double-tilt electron tomography Molecular requirements for actin-based lamella formation in Drosophila S2 cells Nodaviruses of insects Areas, volumes, packing and protein structure Structure of the reovirus core at 3.6 Å resolution Retroviridae: The retroviruses and their replication Orthomyxoviridae: The viruses and their replication Symmetry, flexibility and permeability in the structure of yeast retrotransposon virus-like particles Implications of lipid microdomains for membrane curvature, budding and fission Vesicle formation at the plasma membrane and trans-Golgi network: The same but different Interferons and other cytokines Double-stranded RNA as a template for gene silencing Ultrastructure and origin of cytplasmic multivesicular bodies induced by carnation Italian ringspot virus Packaging and release of the viral genome Particle polymorphism caused by deletion of a peptide molecular switch in a quasiequivalent icosahedral virus Flock House virus subgenomic RNA3 is replicated and its replication correlates with transactivation of RNA2 Identification of sequences in brome mosaic virus replicase protein 1a that mediate association with endoplasmic reticulum membranes Interactions between the structural domains of the RNA replication proteins of plant-infecting RNA viruses Analysis of the interaction of viral RNA replication proteins by using the yeast two-hybrid assay Quantitative analysis of the hepatitis C virus replication complex Formation of the poliovirus replication complex requires coupled viral translation, vesicle production, and viral RNA synthesis Reversible dissociation of the poliovirus replication complex: functions and interactions of its components in viral RNA synthesis Drosophila cells in culture Electron microscopy methods and protocols Synaptic vesicle populations in saccular hair cells reconstructed by electron tomography Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications Dual-axis tomography: An approach with alignment methods that preserve resolution Transform-based backprojection for volume reconstruction of large format electron microscope tilt series Electron tomography of large, multicomponent biological structures Electron tomography of mitochondria after the arrest of protein import associated with Tom19 depletion We thank Randall Massey and Benjamin August of the University of Wisconsin Medical School Electron Microscopy Facility for assistance with electron microscopy; Priscilla Van Wynsberghe and Billy Dye for helpful discussions; Dan Lautenschlager, Steve Lamont, and Jean Yves-Sgro for computer assistance; and Johan den Boon for critical reading of the manuscript.
    keywords: accumulation; analysis; antibody; area; average; axis; bmv; brutp; cells; complex; complexes; connected; copies; cytoplasm; data; density; diameter; dimensions; distinct; double; drosophila; electron; emt; endoplasmic; features; fhv; fhv rna; figure; flock; free; function; house; hpi; images; immunogold; important; incubation; independent; infected; infection; inner; interior; intermediates; labeling; like; localization; membrane; microscopy; min; mitochondrial; mitochondrial membrane; molecules; mosaic; neck; necked; number; organization; outer; outer mitochondrial; particles; perpendicular; positive; protein; range; rearrangements; reconstruction; replication; replication complex; resolution; results; reticulum; rna; rna replication; rna1; rna2; rnas; section; self; series; shell; similar; single; sites; space; specific; spherules; strand; structure; surface; synthesis; table; templates; thickness; tilt; tomography; transmembrane; understanding; vesicles; viral; viral rna; virus; viruses; volume; þ)rna
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        item: #67 of 68
          id: cord-353815-w35spqqt
      author: Huan, Yuchen
       title: Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields
        date: 2020-10-16
       words: 12289
      flesch: 27
     summary: Archiv Activity and characterization of a pH-sensitive antimicrobial peptide Influence of pH on the activity of thrombin-derived antimicrobial peptides Effects of antimicrobial peptides on growth performance and small intestinal function in broilers under chronic heat stress Grouper (Epinephelus coioides) antimicrobial peptide epinecidin-1 exhibits antiviral activity against foot-andmouth disease virus in vitro A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors Acquired resistance to the rice blast in transgenic rice accumulating the antimicrobial peptide thanatin Characterization and antimicrobial evaluation of SpPR-AMP1, a proline-rich antimicrobial peptide from the mud crab The vast structural diversity of antimicrobial peptides Predicting the minimal inhibitory concentration for antimicrobial peptides with rana-box domain The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding Conformational fine-tuning of pore-forming peptide potency and selectivity Gain-of-function analogues of the pore-forming peptide melittin selected by orthogonal high-throughput screening Comparative analysis of two attacin genes from Hyphantria cunea The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in Staphylococci Antimicrobial peptides: possible anti-infective agents Dalbavancin and telavancin in the treatment of infective endocarditis: a literature review Antimicrobial peptides: application informed by evolution Transcriptome analysis of Streptococcus pneumoniae treated with the designed antimicrobial peptides Intracellular targeting mechanisms by antimicrobial peptides Diptericinlike protein: an immune response gene regulated by the anti-bacterial gene induction pathway in drosophila De novo generation of short antimicrobial peptides with simple amino acid composition The antimicrobial peptides and their potential clinical applications Exploring small cationic peptides of different origin as potential antimicrobial agents in aquaculture Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus Membrane active antimicrobial peptides: translating mechanistic insights to design Mechanism of antifungal activity of antimicrobial peptide APP, a cell-penetrating peptide derivative, against Candida albicans: intracellular DNA binding and cell cycle arrest Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers Effects of the peptide H-OOWW-NH2 and its derived lipopeptide C12-OOWW-NH2 on controlling of citrus postharvest green mold Implicit membrane investigation of the stability of antimicrobial peptide β-barrels and arcs Control of sour rot in citrus fruit by three insect antimicrobial peptides Effects of rabbit sacculus rotundus antimicrobial peptides on the intestinal mucosal immunity in chickens Effect of an antifungal peptide from oyster enzymatic hydrolysates for control of gray mold (Botrytis cinerea) on harvested strawberries Biological activity and structural aspects of PGLa interaction with membrane mimetic systems Membrane pore-formation correlates with the hydrophilic angle of histidine-rich amphipathic peptides with multiple biological activities The first antimicrobial peptide from sea amphibian Regulation of cell division in E. coli Antimicrobial packaging based on ε-polylysine bioactive film for the control of mycotoxigenic fungi in vitro and in bread Nucleation and growth of pores in 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) / cholesterol bilayer by antimicrobial peptides melittin, its mutants and cecropin P1 In vitro and MD simulation study to explore physicochemical parameters for antibacterial peptide to become potent anticancer peptide Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases The value of antimicrobial peptides in the age of resistance Influence of self-assembly on the performance of antimicrobial peptides Kappacin, a novel antibacterial peptide from bovine milk Temporins, small antimicrobial peptides with leishmanicidal activity The host antimicrobial peptide Bac71-35 binds to bacterial ribosomal proteins and inhibits protein synthesis
    keywords: abz; acid; action; active; activities; activity; addition; aeruginosa; afps; agents; agriculture; albicans; amino; amino acid; amphibian; amphipathic; amps; animal; anionic; antibacterial; antibacterial activity; antibiotics; anticancer; antifungal; antimicrobial; antimicrobial activity; antimicrobial peptides; antiviral; application; aspergillus; assembly; aureus; bilayer; binding; biofilm; body; box; cathelicidin; cationic; cell; cell membrane; chain; characterization; charge; chemical; clinical; coli; common; complex; components; composition; concentration; control; coronavirus; cov; covid-19; cyclic; cytoplasm; cytotoxicity; defensins; design; development; differences; different; disease; dna; drug; effect; effective; et al; example; family; figure; flavus; following; food; formation; function; fungi; fusion; glycine; good; gram; growth; hairpin; halogenation; hdps; healing; helical; high; higher; histidine; host; human; husbandry; hybrid; hydrophobic; immune; immunity; important; increase; increasing; infection; inflammatory; inhibit; inhibitory; insect; instance; interactions; intestinal; large; lfcinb; life; like; lipid; ll-37; low; lps; magainin; main; marine; mechanism; medicine; membrane; metal; method; milk; model; modifications; mold; molecular; motif; mrsa; natural; negative; new; nisin; non; novel; peptides; phase; phenylalanine; pore; positive; potential; pramps; presence; problems; production; proline; promising; properties; protease; protein; rana; recent; related; research; residues; resistant; respiratory; review; rich; role; sars; selectivity; self; sequence; short; skin; specific; spike; stability; strong; structure; study; synthesis; synthetic; targeting; targets; temporin; terminal; terminus; thanatin; therapeutic; trp; tryptophan; tumor; use; virus; viruses; wall; wound; yeast
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        item: #68 of 68
          id: cord-356090-oj3d9ail
      author: Gorgun, D.
       title: Binding Mode of SARS-CoV2 Fusion Peptide to Human Cellular Membrane
        date: 2020-10-27
       words: 6071
      flesch: 42
     summary: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster A review of coronavirus disease-2019 (COVID-19) Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus Coronavirus membrane fusion mechanism offers a potential target for antiviral development Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin Mechanisms of viral membrane fusion and its inhibition Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme Virus membrane-fusion proteins: more than one way to make a hairpin Coronavirus binding and entry. To analyze the ensemble of FP membrane binding configurations captured in the 18 HMMM simulations where stable membrane binding was observed, clustering was performed using the z-distances between the the side chain COM and the membrane lipid phosphate plane.
    keywords: atoms; bilayer; binding; cell; cellular; cleavage; clustering; configurations; conformational; core; coronavirus; cov2; cov2 fp; different; domain; dynamics; f823; fig; fp membrane; fppr; fps; fusion; helical; helix; hmmm; host; human; important; independent; infection; initial; insertion; interaction; key; leaflet; lipid; loop; major; membrane; membrane binding; membrane fusion; mode; molecular; multiple; novel; orientation; peptide; process; protein; receptor; replicas; residues; respiratory; results; sars; segment; sequence; severe; simulations; spike; stable; step; structure; study; terminal; terminus; viral
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