item: #1 of 515 id: cord-002070-8y24j34j author: Adney, Danielle R. title: Infection, Replication, and Transmission of Middle East Respiratory Syndrome Coronavirus in Alpacas date: 2016-06-17 words: 3112 flesch: 38 summary: Nasal swab specimens were collected from infected animals immediately before challenge, on days 1-5 postinfection, and on day 10 postinfection. The 3 co-housed animals (A4-A6) were placed in the room with the infected animals 2 days after initial virus infection. keywords: alpacas; animals; camels; cov; infection; mers; virus cache: cord-002070-8y24j34j.txt plain text: cord-002070-8y24j34j.txt item: #2 of 515 id: cord-007828-c7jxj74b author: Memish, Ziad A. title: Middle East respiratory syndrome coronavirus infection control: The missing piece? date: 2014-11-25 words: 1935 flesch: 42 summary: key: cord-007828-c7jxj74b authors: Memish, Ziad A.; Al-Tawfiq, Jaffar A. title: Middle East respiratory syndrome coronavirus infection control: The missing piece? date: 2014-11-25 journal: Am J Infect Control DOI: 10.1016/j.ajic.2014.08.003 sha: doc_id: 7828 cord_uid: c7jxj74b nan Since the initial occurrence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, 1,2 the disease had caused 837 cases, with a case fatality rate of 34.7%. Epidemiological update Middle East respiratory syndrome coronavirus (MERS-CoV) Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature updateeas of 9 Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Assessment of potential risk factors of infection of Middle East respiratory syndrome coronavirus (MERS-CoV) among health care personnel in a health care setting Global alert and response (GAR): infection prevention and control of epidemic-and pandemic-prone acute respiratory infections in health care Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Infection prevention and control measures for acute respiratory infections in healthcare settings: an update Identification of a novel coronavirus in patients with severe acute respiratory syndrome Severe acute respiratory syndrome The severe acute respiratory syndrome World Health Organization. keywords: coronavirus; cov; infection; mers; syndrome cache: cord-007828-c7jxj74b.txt plain text: cord-007828-c7jxj74b.txt item: #3 of 515 id: cord-009476-4emc4o6n author: Madani, Tariq A title: Case definition and management of patients with MERS coronavirus in Saudi Arabia date: 2014-09-22 words: 1014 flesch: 20 summary: More eff ective and wider partnerships based on equity and best ethical practice, across governments, health care, academia, industry, and with the public, are essential to eff ectively galvanise economic, political and scientifi c measures required to develop core capacities, including legislation, national focal points, and pandemic planning to reduce risk of global spread and reduce the burden of respiratory tract infectious diseases. 15 An important priority for control of infectious disease is to ensure that scientifi c and technological advances in molecular diagnostics and bioinformatics are well integrated into public health. keywords: case; cov; health; mers cache: cord-009476-4emc4o6n.txt plain text: cord-009476-4emc4o6n.txt item: #4 of 515 id: cord-009594-0rfbmi0q author: None title: NEWS date: 2014-11-26 words: 10481 flesch: 53 summary: The Canadian Veterinary Medical Association (CVMA) has an Animal Welfare Committee whose purpose is to advocate and promote animal welfare within the animal industry, to government and the public, and to advise the CVMA on animal welfare issues and develop pertinent position statements. Is there a common thread or philosophy on animal welfare across all members? keywords: animal; ava; board; dogs; ebola; health; human; lig; members; mers; resolution; safety; sheep; time; use; veterinary; welfare; work; year cache: cord-009594-0rfbmi0q.txt plain text: cord-009594-0rfbmi0q.txt item: #5 of 515 id: cord-014546-arw4saeh author: Janies, Daniel A. title: Spread of Middle East Respiratory Coronavirus: Genetic versus Epidemiological Data date: 2017-05-01 words: 852 flesch: 57 summary: We conclude that epidemiological data combined with genetic data and metadata have strong potential to understand the geographic progression of an infectious disease. Our goal is to develop methods for understanding syndromic and pathogen genetic data on the spread of diseases. keywords: data; spread; transmission cache: cord-014546-arw4saeh.txt plain text: cord-014546-arw4saeh.txt item: #6 of 515 id: cord-016451-k8m2xz0e author: Chertow, Daniel S. title: Influenza, Measles, SARS, MERS, and Smallpox date: 2020-01-03 words: 6148 flesch: 36 summary: The timeline of influenza virus shedding in children and adults in a household transmission study of influenza in Managua Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature Influenza virus-induced lung injury: pathogenesis and implications for treatment The pathology of influenza virus infections Bacterial coinfection in influenza: a grand rounds review Human infection with highly pathogenic avian influenza A(H7N9) virus, China Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif Immunobiology of influenza vaccines Airborne transmission of measles in a physician's office Measles virus host invasion and pathogenesis Pathological consequences of systemic measles virus infection Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques The clinical significance of measles: a review The basic reproduction number (R0) of measles: a systematic review Early waning of maternal measles antibodies in era of measles elimination: longitudinal study Measles virus-induced suppression of immune responses Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality Evidence of airborne transmission of the severe acute respiratory syndrome virus Model parameters and outbreak control for SARS Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Multiple organ infection and the pathogenesis of SARS Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Seasonal influenza virus infection is largely limited to the respiratory tract; however, H5 and H7 HPAI viruses have a polybasic cleave site within the hemagglutinin allowing for replication outside of the respiratory tract [65, 66] . keywords: acute; coronavirus; cov; days; disease; east; infection; influenza; measles; mers; middle; patients; sars; smallpox; syndrome; transmission cache: cord-016451-k8m2xz0e.txt plain text: cord-016451-k8m2xz0e.txt item: #7 of 515 id: cord-016842-sow7k53m author: An, Jisun title: Multidimensional Analysis of the News Consumption of Different Demographic Groups on a Nationwide Scale date: 2017-08-02 words: 6395 flesch: 59 summary: We characterized the news items at the four levels by using the computational techniques, which are topic modeling and the vector representation of words and news items. Figure 2 shows the proportion of news items for each demographic group for each news section. keywords: consumption; daum; differences; female; groups; items; male; mers; news; topic cache: cord-016842-sow7k53m.txt plain text: cord-016842-sow7k53m.txt item: #8 of 515 id: cord-018016-r7tg0s45 author: John, Maya title: Shiny Framework Based Visualization and Analytics Tool for Middle East Respiratory Syndrome date: 2019-12-04 words: 2525 flesch: 62 summary: By viewing the data visualizations, users can analyze MERS cases better, find trends, monitor the disease and help authorities set detection and prevention guidelines. Figure 7 confirms the earlier findings that Riyadh region and specifically Wadi Aldawasir city has the highest number of MERS cases and death cases. keywords: analysis; cases; data; region cache: cord-018016-r7tg0s45.txt plain text: cord-018016-r7tg0s45.txt item: #9 of 515 id: cord-018239-n7axd9bq author: Rusoke-Dierich, Olaf title: Travel Medicine date: 2018-03-13 words: 8534 flesch: 57 summary: If diarrhoea contains blood or mucus in combination of high fever for more than 2 days, more thorough assessment is required. Severe cases show high fever, neck stiffness, photophobia, headache, disorientation, coma, convulsions, spastic paralysis or death. keywords: blood; countries; days; diagnosis; disease; fever; incubation; infections; malaria; phase; risk; symptoms; treatment; vaccination; weeks; years cache: cord-018239-n7axd9bq.txt plain text: cord-018239-n7axd9bq.txt item: #10 of 515 id: cord-018438-1tkevj8v author: Edholm, Christina J. title: Searching for Superspreaders: Identifying Epidemic Patterns Associated with Superspreading Events in Stochastic Models date: 2018-10-25 words: 6322 flesch: 52 summary: Additional classes for asymptomatic, hospitalized, or isolated individuals were also included in MERS models In particular, as disease outbreaks occur more rapidly and more frequently when initiated by superspreaders, our results emphasize the need for expeditious public health interventions. keywords: disease; ebola; individuals; mers; model; number; outbreak; time cache: cord-018438-1tkevj8v.txt plain text: cord-018438-1tkevj8v.txt item: #11 of 515 id: cord-018504-qqsmn72u author: Caron, Rosemary M. title: Public Health Lessons: Practicing and Teaching Public Health date: 2014-09-23 words: 9044 flesch: 46 summary: CBPR …in public health focuses on social, structural, and physical environmental inequities through active involvement of community members, organizational representatives, and researchers in all aspects of the research process. Some examples of how public health works to prevent additional illness include identifying close contacts to the infected person and recommending prophylaxis medication to prevent them from becoming ill (antibiotics, antivirals, vaccine, etc.), providing disease prevention recommendations (washing hands, covering cough, etc.), recognizing outbreaks, and identifying and controlling their source (healthcare-associated outbreaks, foodborne outbreaks, etc.). keywords: antibiotic; care; cdc; community; cov; cre; drug; health; infection; lead; mers; patients; prevention; public; risk cache: cord-018504-qqsmn72u.txt plain text: cord-018504-qqsmn72u.txt item: #12 of 515 id: cord-022046-q1exf47s author: Toosy, Arshad Haroon title: An Overview of Middle East Respiratory Syndrome in the Middle East date: 2018-09-28 words: 2929 flesch: 43 summary: Available at An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronaviruses in dromedary camels Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Antibodies against MERS coronavirus in dromedaries Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Isolation of MERS Coronavirus from a Dromedary Camel MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia 5, 10 The temporal dynamics of MERS infection in DCs in Al-Ahsa, KSA, was examined by collecting nasal swabs and lung tissue during postmortem examination from two independent groups of animals over the course of a year and testing these for MERS-CoV RNA by real-time reverse-transcriptase polymerase chain reaction (RT-rtPCR). keywords: coronavirus; cov; disease; east; human; infection; mers; middle; syndrome cache: cord-022046-q1exf47s.txt plain text: cord-022046-q1exf47s.txt item: #13 of 515 id: cord-024569-d9opzb6m author: Seo, Mihye title: Amplifying Panic and Facilitating Prevention: Multifaceted Effects of Traditional and Social Media Use During the 2015 MERS Crisis in South Korea date: 2019-07-26 words: 8123 flesch: 39 summary: The null effect of social media use on MERS knowledge might thus result from the conflicting content of social media. Analysis of a two-wave online panel survey found that traditional media use had a positive influence on MERS knowledge while social media use did not. keywords: behaviors; communication; crisis; government; health; information; knowledge; media; media use; mers; public; responses; risk; use cache: cord-024569-d9opzb6m.txt plain text: cord-024569-d9opzb6m.txt item: #14 of 515 id: cord-103046-w8bm4p44 author: Suarez, David L. title: Lack of susceptibility of poultry to SARS-CoV-2 and MERS-CoV date: 2020-06-16 words: 566 flesch: 43 summary: key: cord-103046-w8bm4p44 authors: Suarez, David L.; Pantin-Jackwood, Mary J.; Swayne, David E.; Lee, Scott A.; DeBlois, Suzanne M.; Spackman, Erica title: Lack of susceptibility of poultry to SARS-CoV-2 and MERS-CoV date: 2020-06-16 journal: bioRxiv DOI: 10.1101/2020.06.16.154658 sha: doc_id: 103046 cord_uid: w8bm4p44 Chickens, turkeys, ducks, quail and geese were challenged with SARS-CoV-2 or MERS-CoV. Science MERS-CoV: a global challenge Human Coronavirus Infections-Severe Acute 113 Middle East Respiratory Syndrome (MERS), and SARS-114 Reference Module in Biomedical Sciences Identification of MERS-CoV in dromedary camels Middle East 118 respiratory syndrome coronavirus infection in non-camelid domestic mammals. keywords: cov; mers cache: cord-103046-w8bm4p44.txt plain text: cord-103046-w8bm4p44.txt item: #15 of 515 id: cord-103739-mmkrwj8t author: Snijder, Eric J. title: A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis date: 2020-03-24 words: 3813 flesch: 35 summary: However, it is not clear that DMVs always play the primary role 421 in virus replication that we demonstrate here for CoV. For picornaviruses, for example, virus- were freeze-substituted in a Leica AFS2 system with 0.1% (wt/vol) uranyl acetate as 576 previously described [71] , with the only modification that acetone was replaced by ethanol 577 from the last washing step before Lowycril infiltration onwards. The comprehensive analysis presented here demonstrates that viruses across different CoV 371 genera induce essentially the same type of membrane structures. keywords: autoradiography; coronavirus; cov; dmss; dmvs; membrane; replication; rna; virus cache: cord-103739-mmkrwj8t.txt plain text: cord-103739-mmkrwj8t.txt item: #16 of 515 id: cord-103899-6tqm99g1 author: Mirzaei, Rasoul title: The emerging role of microRNAs in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection date: 2020-11-13 words: 9770 flesch: 42 summary: [121] Global Trends in Epidemiology of Coronavirus Disease 2019 (COVID-19) Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses A realistic two-strain model for MERS-CoV infection uncovers the high risk for epidemic propagation Development of genetic diagnostic methods for novel coronavirus 2019 (nCoV-2019) in Japan How miRNAs can protect humans from coronaviruses COVID-19 Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine Clinical features of patients infected with 2019 novel coronavirus in Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments A novel coronavirus outbreak of global health concern Bacterial co-infections with SARS-CoV-2 COVID-19, SARS and MERS: are they closely related? Coronavirus disease (COVID-19) pandemic Exosome and exosomal microRNA: trafficking, sorting, and function Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism Role of microRNAs in the immune system, inflammation and cancer MicroRNAs and the immune response to respiratory virus infections Host Immune Response and Immunobiology of Human SARS-CoV-2 Infection The human immune system against Staphylococcus epidermidis Prevalence of atlE, ica, mecA, and mupA Genes in Staphylococcus epidermidis Isolates T cell-mediated immune response to respiratory coronaviruses Structural, glycosylation and antigenic variation between 2019 novel coronavirus (2019-nCoV) and SARS coronavirus (SARS-CoV) T cell responses to whole SARS coronavirus in humans Profile of specific antibodies to the SARS-associated coronavirus Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus Vaccine-elicited CD8+ T cells protect against respiratory syncytial virus strain A2-line19F-induced pathogenesis in BALB/c mice Interferon interplay helps tissue cells to cope with SARS-coronavirus infection CD8+ T cells and macrophages regulate pathogenesis in a mouse model of Middle East respiratory syndrome Dysregulation of immune response in patients with COVID-19 in Immunopathology of SARS-CoV-2 infection: immune cells and mediators, prognostic factors, and immune-therapeutic implications A contemporary review on pathogenesis and immunity of COVID-19 infection In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients Pathological findings of COVID-19 associated with acute respiratory distress syndrome Cytokine storm induced by SARS-CoV-2 Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome COVID-19: consider cytokine storm syndromes and immunosuppression Pattern recognition receptors and inflammation Activation of airway epithelial cells by toll-like receptor agonists NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses Advances in microRNAs: implications for immunity and inflammatory diseases Expression and function of micro RNAs in immune cells during normal or disease state Integrating microRNAs into a system biology approach to acute lung injury miR-146a is critical for endotoxin-induced tolerance , regulates murine macrophage inflammatory responses Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium Retinoic acidinducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through downregulation of the very low density lipoprotein receptor MicroRNAs: small RNAs with big effects MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation, Seminars in cancer biology Skare, miR-181a is an intrinsic modulator of T cell sensitivity and selection Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes MicroRNA miR-155 affects antiviral effector and effector Memory CD8 T cell differentiation Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges Rosas-Taraco, microRNAs in viral acute respiratory infections: immune regulation, biomarkers, therapy, and vaccines A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany Structure of a human common cold virus and functional relationship to other picornaviruses Rhinovirus and dsRNA induce RIG-I-like receptors and expression of interferon β keywords: cells; coronavirus; cov-2; covid-19; expression; host; human; infection; mers; micrornas; mirnas; proteins; replication; responses; rsv; sars; study; target; virus cache: cord-103899-6tqm99g1.txt plain text: cord-103899-6tqm99g1.txt item: #17 of 515 id: cord-104500-m0kfom0x author: Kyriakopoulos, Anthony M. title: The Potential Role of Super Spread Events in SARS-COV-2 Pandemic; a Narrative Review date: 2020-09-21 words: 6850 flesch: 31 summary: Lessons from SARS epidemic taught us that the key to control is minimizing the time from the diagnosis of infection to prompt hospital isolation and diminishing the probability Table 3 : Key clinical and laboratory screening functions to appropriately forecast, prevent, and confront SARS! SARS epidemic taught us that control programs were inefficient in controlling the epidemic within a population, and failed to identify and provide a targeted infection diagnosis in groups causing potential SSEs (5, 17) . keywords: articles; coronavirus; cov-2; covid-19; disease; epidemic; hepatitis; human; infection; mers; potential; sars; sses; super; syndrome; transmission cache: cord-104500-m0kfom0x.txt plain text: cord-104500-m0kfom0x.txt item: #18 of 515 id: cord-227268-8k9zaqsy author: Wick, W. David title: Stopping the SuperSpreader Epidemic: the lessons from SARS (with, perhaps, applications to MERS) date: 2013-08-29 words: 6789 flesch: 50 summary: The conclusions may surprise the reader: (a) The SS epidemic must be described by at least two numbers, such as the mean reproductive number (ofsecondarycases caused by aprimary case), R0, and the variance of same, call it V0; (b) Even if R0>1, if V0>>R0 the probability that an infection-chain caused by one primary case goes extinct without intervention may be close to one (e.g., 0.97); (c) The SS epidemic may have a longkindling periodin which sporadic cases appear (transmitted from some unknown host) and generate a cluster of cases, but the chains peter out, perhaps generating a false sense of security that a pandemic will not occur; (d) Interventions such as isolation (or contact-tracing and secondary case isolation) may prove efficacious even without driving R0 below one; (e) The efficacy of such interventions diminishes, but slowly, with increasing V0 at fixed R0. The conclusions may surprise the reader: (a) the SS epidemic must be described by at least two numbers, such as the mean reproductive number (of secondary infections caused by a primary case), R 0 , and the variance of same, call it V 0 ; (b) Even with R 0 > 1, if V 0 R 0 the probability that the infection-chain caused by one primary case goes extinct without intervention may be close to one (e.g., 0.97); (c) The SS epidemic may have a long kindling period in which sporadic cases appear (transmitted from some unknown host) and generate a cluster of cases, but the chains peter out, perhaps generating a false sense of security that a pandemic will not occur; (d) Interventions such as isolating primary cases (or contact-tracing and secondary-case isolation) can be efficacious even without driving R 0 below one; (e) The efficacy of such interventions diminishes, but slowly, with increasing V 0 at fixed R 0 . keywords: case; epidemic; intervention; model; period; time cache: cord-227268-8k9zaqsy.txt plain text: cord-227268-8k9zaqsy.txt item: #19 of 515 id: cord-252049-rgdynmla author: Tomar, Sakshi title: Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS date: 2015-06-08 words: 11873 flesch: 43 summary: On the contrary, noncovalent peptidomimetic compounds (for example, compounds 10 and 11) inhibit the enzymatic activity of MERS-CoV 3CL pro only at high compound concentrations. Moreover, inhibition by compound 10 occurred at lower compound concentrations when higher concentrations of enzyme were used. keywords: 3cl pro; activity; compound; concentrations; coronavirus; cov 3cl; data; dimer; dimerization; enzyme; fig; inhibitor; ligand; mers; monomer; sars; site; substrate cache: cord-252049-rgdynmla.txt plain text: cord-252049-rgdynmla.txt item: #20 of 515 id: cord-252397-qlu7dilh author: Johnson, Reed F. title: Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease date: 2015-11-01 words: 5030 flesch: 42 summary: Day 4 or 5 was chosen based on our data from MERS-JOR inoculated rhesus monkeys which demonstrated a peak in lung disease at day 5 post-inoculation by CT (manuscript in preparation). Media only, and inactivated virus did not develop detectable neutralizing antibody responses to MERS-CoV. Qualitative assessment of the imaging data indicates that MERS-CoV inoculated marmosets developed lung disease that mainly affected the medial and caudal regions of the lung. keywords: cov; data; disease; emc; group; inoculated; inoculation; lung; marmosets; mers; subjects; virus cache: cord-252397-qlu7dilh.txt plain text: cord-252397-qlu7dilh.txt item: #21 of 515 id: cord-252456-971d0sir author: Hemida, Maged Gomaa title: The SARS-CoV-2 outbreak from a one health perspective date: 2020-03-16 words: 4830 flesch: 51 summary: Emerg Infect Dis Avian Influenza Virus Detection Rates in Poultry and Environment at Live Poultry Markets Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by Controversy around airborne versus droplet transmission of respiratory viruses: implication for infection prevention Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination Isolation and identification of human coronavirus 229E from frequently touched environmental surfaces of a university classroom that is cleaned daily Extensive Viable Middle East Respiratory Syndrome (MERS) Meanwhile, the effect of temperature on the virus infectivity/survival has great impact on the control of this class of respiratory viruses. keywords: control; coronavirus; cov; cov-2; health; mers; novel; sars; virus; viruses cache: cord-252456-971d0sir.txt plain text: cord-252456-971d0sir.txt item: #22 of 515 id: cord-252600-bvh1o64r author: Galasiti Kankanamalage, Anushka C. title: Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element date: 2018-04-25 words: 4766 flesch: 44 summary: S n ' correspond to the enzyme subsites on the N-terminus and C-terminus side, respectively, of the scissile bond Structure of main protease from human coronavirus NL63: insights for wide spectrum anti-coronavirus drug design Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Inspection of the structure reveals the presence of prominent electron density consistent with the structure of inhibitor 10c; however, the N-Bocpiperidinyl moiety was disordered. keywords: 3clpro; compounds; coronavirus; cov; inhibitor; mers; mixture; mmol; protease; reaction; solution; structure cache: cord-252600-bvh1o64r.txt plain text: cord-252600-bvh1o64r.txt item: #23 of 515 id: cord-252883-1ub01j2x author: Bleibtreu, A. title: Focus on Middle East respiratory syndrome coronavirus (MERS-CoV) date: 2019-11-11 words: 6235 flesch: 47 summary: WHO Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study New case of MERS-CoV identified in the United Kingdom Middle East respiratory syndrome coronavirus (MERS-CoV): prevention in travelers Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Specific serology for emerging human coronaviruses by protein microarray Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015 Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea MERS-CoV outbreak in Jeddah-a link to health care facilities MERS outbreak in Korea: hospital-to-hospital transmission Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Middle East respiratory syndrome coronavirus infections in health care workers Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Hospital outbreak of middle east respiratory syndrome coronavirus Middle East respiratory syndrome A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes Rapid risk assessment: Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV), 22nd update Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus infection: a short note on cases with renal failure problem State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea IFN-(2a or IFN-(1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Viral RNA in blood as Indicator of Severe Outcome in Middle East Respiratory Syndrome Coronavirus Infection Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Prevention and treatment of respiratory viral infections: presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): a review Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study A review of treatment modalities for Middle East Respiratory Syndrome Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Treatment With Lopinavir/Ritonavir or Interferon-(1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Alisporivir inhibits MERS-and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona-and picornaviruses Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice The chapters on the origin, emergence, structure, transmission mechanisms, prevention and diagnostic methods were mainly written MB, NH, and BV.BV produced the figures. Consensus document on the epidemiology of severe acute respiratory syndrome (SARS) Molecular evolution of human coronavirus genomes Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Severe respiratory illness caused by a novel coronavirus WHO | Background and summary of novel coronavirus infection-as of 21 Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological stud Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia MERS coronavirus neutralizing antibodies in camels Antibodies against MERS coronavirus in dromedary camels Risk factors for MERS coronavirus infection in dromedary camels in Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein A structural analysis of M protein in coronavirus assembly and morphology East respiratory syndrome coronavirus (MERS-CoV)-update. keywords: arabia; cases; coronavirus; cov; east; human; infection; mers; middle; outbreak; patients; saudi; study; syndrome cache: cord-252883-1ub01j2x.txt plain text: cord-252883-1ub01j2x.txt item: #24 of 515 id: cord-253077-61fmul8c author: Vabret, Nicolas title: Immunology of COVID-19: current state of the science date: 2020-05-06 words: 20264 flesch: 30 summary: Tan et al. proposed a prognostic model based on lymphocyte counts at two time points: patients with less than 20% lymphocytes at days 10-12 from the onset of symptoms and less than 5% at days 17-19 had the worst outcomes in this study (Tan et al., 2020a) . Antibodies binding the SARS-CoV-2 internal N protein and the external S glycoprotein are commonly detected (Amanat et al., 2020; Ju et al., 2020; . keywords: 2020b; antibodies; antibody; blood; cd4; cells; coronavirus; cov-2; covid-19; covid-19 patients; cytokine; disease; et al; hcq; human; ifn; immune; infection; inflammatory; levels; lung; mers; patients; potential; protein; respiratory; responses; sars; sars coronavirus; severity; specific; studies; study; syndrome; t cells; treatment; vaccine cache: cord-253077-61fmul8c.txt plain text: cord-253077-61fmul8c.txt item: #25 of 515 id: cord-253238-ptmxkpae author: Kopel, Jonathan title: Clinical Insights into the Gastrointestinal Manifestations of COVID-19 date: 2020-05-23 words: 4158 flesch: 41 summary: Given the high percentage of COVID-19 patients that present with GI symptoms (e.g., nausea and diarrhea), screening patients for GI symptoms remain essential. Given the high percentage of COVID-19 patients that present with GI symptoms (diarrhea, nausea, etc.), screening these patients is essential. keywords: cases; coronavirus; covid-19; disease; human; infection; patients; sars; symptoms; syndrome cache: cord-253238-ptmxkpae.txt plain text: cord-253238-ptmxkpae.txt item: #26 of 515 id: cord-253337-xdexrlq3 author: Park, Jung Wan title: Hospital Outbreaks of Middle East Respiratory Syndrome, Daejeon, South Korea, 2015 date: 2017-06-17 words: 4555 flesch: 51 summary: Subsequently, 2 hospitals in Daejeon experienced MERS cases attributable to this patient. South Korea operates a nationwide medical insurance scheme; all costs incurred by MERS patients were covered. keywords: case; daejeon; hospital; index; korea; mers; patient cache: cord-253337-xdexrlq3.txt plain text: cord-253337-xdexrlq3.txt item: #27 of 515 id: cord-254976-la9g6g5t author: Kim, Ji Soo title: Factors Influencing Emergency Nurses' Burnout During an Outbreak of Middle East Respiratory Syndrome Coronavirus in Korea date: 2016-11-09 words: 4185 flesch: 54 summary: However, not even a basic survey has been conducted on the level of burnout experienced by ED nurses, who are in the front line taking care of MERS-CoV patients, or factors of burnout that consider the specific nature of MERS-CoV. Thus, this study attempted to assess ED nurses' burnout level during an outbreak of MERS-CoV and to identify influencing factors in order to provide basic information for lowering and preventing the level of burnout. This also suggests the necessity for programs designed to help manage and control burnout levels in ED nurses during the outbreak of an infectious disease like MERS-CoV. In the univariate analysis, MERS-CoV-related burnout was significantly higher in nurses working under the three-shift system and in those with experience in caring for MERS-CoVinfected or MERS-CoV-suspected patients. keywords: burnout; cov; mers; nurses; stress cache: cord-254976-la9g6g5t.txt plain text: cord-254976-la9g6g5t.txt item: #28 of 515 id: cord-255339-oudj079q author: Al-Tayib, Omar A. title: An Overview of the Most Significant Zoonotic Viral Pathogens Transmitted from Animal to Human in Saudi Arabia date: 2019-02-22 words: 15858 flesch: 42 summary: Borne Zoonotic Dis Update on the global spread of dengue Virologic and serologic surveillance for dengue fever in Jeddah, Saudi Arabia, 1994-1999 Clinical profile and outcome of hospitalized patients during first outbreak of dengue in Makkah, Saudi Arabia Department of Communicable Diseases, Ministry of Health (MOH) Saudi Arabia Ministry of Health: Riyadh, Saudi Arabia Phylogeny of dengue viruses circulating in Jeddah Reconstructing historical changes in the force of infection of dengue fever in Singapore: Implications for surveillance and control Dengue fever Clinical features of 567 consecutive patients admitted to a tertiary care center in Saudi Arabia Characteristics of dengue fever in a large public hospital Factors associated with the spread of dengue fever in Jeddah Governorate, Saudi Arabia. According to a March 3 statement, another patient, a 74-year-old man from Najran located in southern Saudi Arabia, was reported. keywords: animals; camels; cases; control; countries; cov; data; disease; fever; health; human; infection; influenza; influenza virus; jeddah; mers; pathogens; patients; rabies; saudi arabia; studies; study; virus; viruses; zoonotic cache: cord-255339-oudj079q.txt plain text: cord-255339-oudj079q.txt item: #29 of 515 id: cord-255378-qgklt8wa author: Huang, Yi-Ping title: NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV) date: 2016-03-18 words: 1268 flesch: 43 summary: Finally, macro domain protein (20 kDa, with extra Gly, Ser, His and Met at N-terminus) was purified using size-exclusion Superdex75 XK 16/60 column (GE, Healthcare). In addition, viral macro proteins may act via ADP-ribose binding to influence the cellular macro domains-regulated pathways either to promote virus replication or to inhibit host responses directed against the virus (Neuvonen and Ahola 2009 ). keywords: cov; domain; macro; mers; nmr; protein cache: cord-255378-qgklt8wa.txt plain text: cord-255378-qgklt8wa.txt item: #30 of 515 id: cord-255488-nvgz53su author: Li, Kun title: Development of a Mouse-Adapted MERS Coronavirus date: 2019-09-14 words: 2949 flesch: 58 summary: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Person-toperson spread of the MERS coronavirus-an evolving picture The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Spread of MERS to South Korea and China Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East respiratory syndrome coronavirus (MERS-CoV) Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Pathogenicity and viral shedding of MERS-CoV in immunocompromised rhesus macaques Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Infection with MERS-CoV causes lethal pneumonia in the common marmoset Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East Coronavirus DOI: 10.1007/978-1-0716-0211-9_13 sha: doc_id: 255488 cord_uid: nvgz53su First identified in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that can cause acute respiratory distress syndrome (ARDS), multiorgan failure, and death, with a case fatality rate of ~35%. keywords: coronavirus; cov; infection; mers; mice; middle; mouse; syndrome cache: cord-255488-nvgz53su.txt plain text: cord-255488-nvgz53su.txt item: #31 of 515 id: cord-255628-bm4nogig author: Su, Shuo title: MERS in South Korea and China: a potential outbreak threat? date: 2015-06-11 words: 1180 flesch: 54 summary: These developments are worrisome given Favipiravir-a prophylactic treatment for Ebola contacts? Such a scenario is possible in people who contract Ebola virus before vaccination. keywords: cov; ebola; mers; year cache: cord-255628-bm4nogig.txt plain text: cord-255628-bm4nogig.txt item: #32 of 515 id: cord-255815-5d9bqji0 author: Malik, Ajamaluddin title: MERS‐CoV papain-like protease (PL(pro)): expression, purification, and spectroscopic/thermodynamic characterization date: 2017-05-30 words: 3934 flesch: 50 summary: MERS-CoV main protease (M pro , also called the 3C-like protease, 3CL pro ) cleaves at eleven sites, while MERS-CoV papain-like protease (PL pro ) cuts at three sites on the nonstructural polypeptides and releases mature nonstructural proteins (Hilgenfeld 2014) . MERS-CoV PL pro consists of two domains: N-terminal ubiquitinlike (Ubl) domain and a catalytic core domain. keywords: cov; fluorescence; mers; pro; shift; temperature; thermal cache: cord-255815-5d9bqji0.txt plain text: cord-255815-5d9bqji0.txt item: #33 of 515 id: cord-255871-dau9tz6u author: Lee, Mi-Kyung title: Survey of Clinical Laboratory Practices for 2015 Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea date: 2015-12-18 words: 2612 flesch: 43 summary: Clinical laboratories were able to quickly expand their diagnostic capacity in response to the 2015 MERS-CoV outbreak. Our results show that clinical laboratories play an important role in the maintenance and enhancement of laboratory response in preparation for future emerging infections. keywords: cov; laboratories; laboratory; mers; outbreak; pcr cache: cord-255871-dau9tz6u.txt plain text: cord-255871-dau9tz6u.txt item: #34 of 515 id: cord-256020-wrui3i2l author: Fadaka, Adewale Oluwaseun title: Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2 date: 2020-08-26 words: 7116 flesch: 43 summary: Certain classes of compounds, called surfactants, are contained in soap and have the ability to neutralize microbes such as SARS CoV-2. A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China A novel coronavirus emerging in China-key questions for impact assessment Recent insights into the biology of pancreatic cancer Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis Current and emerging therapies for patients with advanced pancreatic ductal adenocarcinoma: a bright future SARS and other coronaviruses as causes of pneumonia Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient Potential maternal and infant outcomes from coronavirus 2019-nCoV (SARS-CoV-2) infecting pregnant women: Lessons from SARS, MERS, and other human coronavirus infections Subunit vaccines against emerging pathogenic human coronaviruses Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Viral and cellular mRNA translation in coronavirus-infected cells Molecular evolution of human coronavirus genomes From SARS to MERS, thrusting coronaviruses into the spotlight A complete sequence and comparative analysis of a SARS-associated virus (isolate BJ01) Ultrastructural characterization of SARS coronavirus The genome sequence of the SARS-associated coronavirus Asymptomatic cases in a family cluster with SARS-CoV-2 infection Bat origin of human coronaviruses Isolation and growth characterization of novel full length and deletion mutant human MERS-CoV strains from clinical specimens collected during Middle East Respiratory Syndrome: Emergence of a pathogenic human coronavirus Cryo-electron tomography of mouse hepatitis virus: insights into the structure of the coronavirion Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex keywords: cases; cells; coronavirus; cov-2; covid-19; covs; disease; figure; human; infection; mers; novel; patients; protein; receptor; sars; symptoms cache: cord-256020-wrui3i2l.txt plain text: cord-256020-wrui3i2l.txt item: #35 of 515 id: cord-256086-8qfeoayb author: Lin, Leesa title: Tuning in and catching on? Examining the relationship between pandemic communication and awareness and knowledge of MERS in the USA date: 2016-04-15 words: 3653 flesch: 35 summary: Different reasons for getting vaccinated against seasonal or pandemic influenza Early responses to H7N9 in southern Mainland China Awareness, anxiety, compliance: community perceptions and response to the threat and reality of an influenza pandemic Chinese urban-rural disparity in pandemic (H1N1) 2009 vaccination coverage rate and associated determinants: a cross-sectional telephone survey Public health communications and alert fatigue Implications of public understanding of avian influenza for fostering effective risk communication Health Information National Trends Survey (HINTS) 2007: Examining the relationship between pandemic communication and awareness and knowledge of MERS in the USA date: 2016-04-15 journal: J Public Health (Oxf) DOI: 10.1093/pubmed/fdw028 sha: doc_id: 256086 cord_uid: 8qfeoayb BACKGROUND: keywords: awareness; communication; health; knowledge; mers; outbreaks; pandemic; public cache: cord-256086-8qfeoayb.txt plain text: cord-256086-8qfeoayb.txt item: #36 of 515 id: cord-256300-emsvxxs5 author: Tortorici, M. Alejandra title: Structural insights into coronavirus entry date: 2019-08-22 words: 6551 flesch: 22 summary: A common feature observed in the glycosylation patterns of S glycoproteins is the presence of less densely glycosylated regions surrounding the S 1 /S 2 cleavage site and the conserved fusion peptide, near the S 2 ' cleavage site, probably to allow access to activating host proteases and for membrane fusion to take place (Walls et al., 2016b; Walls et al., 2019) (Fig. 5) . Proteolysis at the conserved S 2 ' site is essential for fusion activation of all characterized CoV S proteins, and it can occur at the host membrane or in internal cellular compartments of the target cell (Belouzard et al., 2009; Burkard et al., 2014; Millet and Whittaker, 2015; Park et al., 2016) . keywords: binding; coronavirus; cov; covs; domain; entry; et al; fusion; human; mers; protein; receptor; sars; spike; walls et cache: cord-256300-emsvxxs5.txt plain text: cord-256300-emsvxxs5.txt item: #37 of 515 id: cord-256537-axbyav1m author: Kimball, Ann Marie title: Emergence of Novel Human Infections: New Insights and New Challenges date: 2016-10-24 words: 4980 flesch: 47 summary: New human infections have continued to come forth over the last decade. So what explains the apparent increased pace of emergence of new human infections? keywords: cases; countries; disease; emergence; health; human; infections; influenza; new; pandemic; sars cache: cord-256537-axbyav1m.txt plain text: cord-256537-axbyav1m.txt item: #38 of 515 id: cord-256750-5m7psxri author: Park, Hye Yoon title: Posttraumatic stress disorder and depression of survivors 12 months after the outbreak of Middle East respiratory syndrome in South Korea date: 2020-05-15 words: 4571 flesch: 44 summary: However, no studies have investigated the mental health status of MERS survivors. The present study was part of a prospective nationwide cohort study of MERS survivors conducted at multicenters in the Republic of Korea. keywords: depression; health; mers; months; outbreak; ptsd; study; survivors cache: cord-256750-5m7psxri.txt plain text: cord-256750-5m7psxri.txt item: #39 of 515 id: cord-256784-wfaqim7d author: Modjarrad, Kayvon title: MERS-CoV vaccine candidates in development: The current landscape date: 2016-06-03 words: 3339 flesch: 34 summary: Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Preand postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Family cluster of Middle East respiratory syndrome coronavirus infections Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Hospital outbreak of Middle East respiratory syndrome coronavirus Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health Hendra virus An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Animal models of Middle East respiratory syndrome coronavirus infection Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia epidemiological findings from a retrospective investigation East Respiratory Syndrome Coronavirus (MERS-CoV) Summary and Literature Update-as of 11 Update: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea A decade after SARS: strategies for controlling emerging coronaviruses Detection of coronaviruses in bats of various species in Italy Diversity of coronavirus in bats from Eastern Thailand MERS-related betacoronavirus in Vespertilio superans bats Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai Antibodies against MERS coronavirus in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus MERS: emergence of a novel human coronavirus Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Update: severe respiratory illness associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-worldwide Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Middle East respiratory syndrome novel corona MERS-CoV infection. keywords: coronavirus; cov; east; human; infection; mers; middle; syndrome; vaccine cache: cord-256784-wfaqim7d.txt plain text: cord-256784-wfaqim7d.txt item: #40 of 515 id: cord-256806-g42n51n9 author: Khudhair, Ahmed title: Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014–2017 date: 2019-05-17 words: 4412 flesch: 38 summary: Previous studies of workers with occupational exposure to camels have reported either lower seropositivity rates (e.g., 6.8% of 294 workers with occupational camel contact seropositive in Qatar [21] and 2.3% of 87 camel shepherds seropositive in Saudi Arabia [20] ) or comparable seropositivity (e.g., 53% of camel workers positive in Saudi Arabia [22] ). WHO MERS-CoV global summary and assessment of risk Middle East respiratory syndrome coronavirus (MERS-CoV) origin and animal reservoir Middle East respiratory syndrome coronavirus (MERS-CoV): animal to human interaction Risk factors for MERS coronavirus infection in dromedary camels in MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Antibodies against MERS coronavirus in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Risk factors for primary Middle East Respiratory syndrome coronavirus illness in humans, Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Occupational exposure to dromedaries and risk for MERS-CoV infection High prevalence of MERS-CoV infection in camel workers in Saudi Arabia Inovio Pharmaceuticals I. Inovio's MERS vaccine generates high levels of antibodies and induces broad-based T Cell responses in phase 1 study Man in Germany dies of complications stemming from Mers virus Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Korean Society of Infectious Diseases. keywords: camels; cov; market; mers; risk; seropositivity; slaughterhouse; workers cache: cord-256806-g42n51n9.txt plain text: cord-256806-g42n51n9.txt item: #41 of 515 id: cord-257511-4ftedh1a author: Gunaratne, Gihan S. title: NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system date: 2018-11-30 words: 8014 flesch: 39 summary: Huh7 cells were treated with indicated drugs for 6 h, starting 1 h prior to incubation with MERS pseudovirus (i.e. a 5 h co-incubation). Pharmacological inhibition of NAADP-evoked Ca2+ release using several bisbenzylisoquinoline alkaloids also blocked MERS pseudovirus translocation. keywords: activity; cells; channels; cov; endolysosomal; fangchinoline; fig; furin; infectivity; inhibition; mers; naadp; pseudovirus; tpc; tpc1; trafficking; translocation cache: cord-257511-4ftedh1a.txt plain text: cord-257511-4ftedh1a.txt item: #42 of 515 id: cord-257587-xjoyrdhj author: Gunaratne, Gihan S. title: A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca2+ signaling in human cells date: 2018-11-30 words: 7614 flesch: 43 summary: The top two hits were PF-543 (rank #1, 6.0 ± 5.0% of control NAADP response) and SKF96365 (rank #2, 6.3 ± 4.5% of control NAADP response). For all these reasons, the system has long been regarded as the 'gold-standard' for studying NAADP action [34, 35] , and has been frequently used to assess the action of molecules eliciting Ca 2+ release through each of the discrete, endogenous Ca 2+ mobilization pathways keywords: cells; compounds; evoked; fig; fluorescence; homogenate; inhibition; mers; naadp; rank; release; screening; sea; signaling; urchin cache: cord-257587-xjoyrdhj.txt plain text: cord-257587-xjoyrdhj.txt item: #43 of 515 id: cord-258032-buh1e4tm author: Tang, Siming title: A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4 date: 2017-08-15 words: 2128 flesch: 60 summary: Rapid generation of a mouse model for Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERSCoV) causes transient lower respiratory tract infection in rhesus macaques MERSE Infectious Diseases of Humans: Dynamics and Control Population dynamics of immune responses to persistent viruses Virus Dynamics: Mathematics Principles of Immunology and Virology Mathematical analysis of HIV-1 dynamics in vivo Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furinmediated activation of the spike protein Global properties of basic virus dynamics models Global asymptotic properties of virus dynamics models with dose-dependent parasite reproduction and virulence and non-linear incidence rate Complete global stability for an SIR epidemic model with delay-distributed or discrete Global properties for virus dynamics model with Beddington-DeAngelis functional response Stability and Hopf bifurcation in a delayed HIV infection model with general incidence rate and immune impairment Based on basic dynamic model (1) and Figure 1 , we propose the following novel four-dimensional dynamic model which describes the spread of the MERS-CoV and the expression of DPP4:̇= In model (2), ( ) represents the concentration of DPP4 on the surface of uninfected cells, which can be recognized by surface spike (S) protein of MERS-CoV (see, e.g., [8] ). keywords: model cache: cord-258032-buh1e4tm.txt plain text: cord-258032-buh1e4tm.txt item: #44 of 515 id: cord-258281-gxwk8jq9 author: Wenling, Yao title: Pregnancy and COVID-19: management and challenges date: 2020-08-31 words: 5024 flesch: 39 summary: Considering that SARS-CoV-2, SARS-CoV, and MERS-CoV are all β-coronaviruses, and their genomes, pathogenesis and clinical symptoms have certain similarities, this article draws lessons from previous studies on SARS-CoV and MERS-CoV infecting pregnant women to predict the impact of SARS-CoV-2 on pregnant women and fetuses and make some suggestions. In the same hospital, another newborn had confirmed COVID-19 infection 17 days after birth and a history of close contact with two confirmed cases 55 , the infant's mother and the maternity matron. keywords: coronavirus; cov-2; covid-19; infection; mers; patients; pregnancy; sars; syndrome; women cache: cord-258281-gxwk8jq9.txt plain text: cord-258281-gxwk8jq9.txt item: #45 of 515 id: cord-258323-vdeffy4l author: Jiang, Yuting title: Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV date: 2019-01-09 words: 4790 flesch: 44 summary: Although there was no significant difference between the two groups with respect to pro-IL-1β mRNA expression ( Figure 5B ), serum levels of IL-1β were lower in the anti-C5aR1 Ab-treated group than in the PBS-treated group at Day 1 ( Figure 5C ) and Although there was no significant difference between the two groups with respect to pro-IL-1β mRNA expression ( Figure 5B ), serum levels of IL-1β were lower in the anti-C5aR1 Ab-treated group than in the PBS-treated group at Day 1 ( Figure 5C ) and keywords: c5ar1; caspase-1; cov; cov infection; expression; figure; il-1β; infection; mers; mice cache: cord-258323-vdeffy4l.txt plain text: cord-258323-vdeffy4l.txt item: #46 of 515 id: cord-258611-uzzs8w1j author: Ma, Xuezheng title: No MERS-CoV but positive influenza viruses in returning Hajj pilgrims, China, 2013–2015 date: 2017-11-10 words: 2150 flesch: 48 summary: In this study, we did not detect any cases of MERS-CoV infection but respiratory virus infections including influenza A and B, hMPV, hRSV, and human coronavirus were detected among Hajj pilgrims returning to China. Our sampling design would therefore include some healthy pilgrims, thereby decreasing the rate of detection of respiratory virus infections. keywords: hajj; influenza; mers; pilgrims; virus cache: cord-258611-uzzs8w1j.txt plain text: cord-258611-uzzs8w1j.txt item: #47 of 515 id: cord-258892-1xmoeoyh author: Thomas, Helen Lucy title: Enhanced MERS Coronavirus Surveillance of Travelers from the Middle East to England date: 2014-09-17 words: 1550 flesch: 38 summary: Emerg Infect Dis DOI: 10.3201/eid2009.140817 sha: doc_id: 258892 cord_uid: 1xmoeoyh During the first year of enhanced MERS coronavirus surveillance in England, 77 persons traveling from the Middle East had acute respiratory illness and were tested for the virus. During the first year of enhanced MERS coronavirus surveillance in England, 77 persons traveling from the Middle East had acute respiratory illness and were tested for the virus. keywords: case; cov; mers; patients cache: cord-258892-1xmoeoyh.txt plain text: cord-258892-1xmoeoyh.txt item: #48 of 515 id: cord-259051-6kuh4njb author: Elkholy, Amgad A. title: MERS-CoV infection among healthcare workers and risk factors for death: Retrospective analysis of all laboratory-confirmed cases reported to WHO from 2012 to 2 June 2018 date: 2019-05-02 words: 3283 flesch: 38 summary: Compared with non-healthcare workers cases, healthcare workers cases were younger (P < 0.001), more likely to be female (P < 0.001), non-nationals (P < 0.001) and asymptomatic (P < 0.001), and have fewer comorbidities (P < 0.001) and higher rates of survival (P < 0.001). Specific IPC measures which may have contributed to the decreased case fatality rate include more systematic use of appropriate personal protective equipment and increased testing of asymptomatic personnel which effectively increases the detection of asymptomatic healthcare workers who are less likely to die, therefore increasing the denominator of healthcare worker cases and decreasing the case fatality rate. keywords: cases; cov; healthcare; infection; mers; workers cache: cord-259051-6kuh4njb.txt plain text: cord-259051-6kuh4njb.txt item: #49 of 515 id: cord-259200-65b267ic author: Harypursat, Vijay title: Six weeks into the 2019 coronavirus disease outbreak: it is time to consider strategies to impede the emergence of new zoonotic infections date: 2020-05-05 words: 1724 flesch: 34 summary: The complete ban on market trading and sale of wild game meat in China on January 26th, 2020 will help prevent zoonotic transmission of 2019-nCoV in the current epidemic and, to a certain degree, help prevent emergence of new zoonotic infections. It is, therefore, an urgent priority for local and international health and wildlife regulatory authorities to structure and implement robust control mechanisms that effectively reduce human exposure to wild game meat and their products. keywords: human; ncov; outbreak; sars cache: cord-259200-65b267ic.txt plain text: cord-259200-65b267ic.txt item: #50 of 515 id: cord-259347-3acsko74 author: Cheng, Qi title: Infectivity of human coronavirus in the brain date: 2020-05-28 words: 3996 flesch: 37 summary: We declare no conflicts of interest. Identification of an epitope of SARS-coronavirus nucleocapsid protein Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome Neuroinvasion by human respiratory coronaviruses Vacuolating encephalitis in mice infected by human coronavirus OC43 Human respiratory coronavirus OC43: genetic stability and neuroinvasion Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Neurological manifestations in COVID-19 caused by SARS-CoV-2 Persistent infection of human oligodendrocytic and neuroglial cell lines by human coronavirus 229E Acute and persistent infection of human neural cell lines by human coronavirus OC43 Infection of primary cultures of human neural cells by human coronaviruses 229E and OC43 Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immunemediated Susceptibility of murine CNS to OC43 infection Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43 Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis Human Coronavirus OC43 Associated with Fatal Encephalitis A rare cause of acute flaccid paralysis: human coronaviruses Susceptibility of human and rat neural cell lines to infection by SARS-coronavirus Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2 Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human Dipeptidyl peptidase 4 Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis Multiple organ infection and the pathogenesis of SARS Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Possible central nervous system infection by SARS coronavirus Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV) Neurological Complications of Middle East Respiratory Syndrome Coronavirus: a Report of Two Cases and Review of the Literature Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain Viremic dissemination of mouse hepatitis virus-JHM following intranasal inoculation of mice Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease Immunological and neuropathological significance of the Virchow-Robin space Dilated Virchow-Robin spaces in cryptococcal meningitis associated with AIDS: CT and MR findings The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Persistence of physical symptoms in and abnormal laboratory findings for survivors of severe acute respiratory syndrome Posttraumatic stress, anxiety, and depression in survivors of severe acute respiratory syndrome (SARS) Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice Murine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. keywords: acute; brain; cns; coronavirus; cov; human; infection; sars; syndrome cache: cord-259347-3acsko74.txt plain text: cord-259347-3acsko74.txt item: #51 of 515 id: cord-259374-m7q1roay author: Agostini, Maria L. title: Small-Molecule Antiviral β-d-N(4)-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance date: 2019-11-26 words: 6115 flesch: 40 summary: We observed a modest (approximately 2-fold) increase in EC 90 values for MHV NHC passage viruses (WT MHV, EC 90 ϭ 1.53 M; MHV p30.1, EC 90 ϭ 2.61 M; MHV p30.2, EC 90 ϭ 2.41 M) (Fig. 6B ). These results point to a virus-mutagenic mechanism of NHC inhibition in CoVs and indicate a high genetic barrier to NHC resistance. keywords: cov; covs; fig; inhibition; mers; mhv; mutations; nhc; passage; replication; resistance; rna; virus cache: cord-259374-m7q1roay.txt plain text: cord-259374-m7q1roay.txt item: #52 of 515 id: cord-259443-5sv3dwbs author: Banik, Gouri Rani title: Risk factors for severity and mortality in patients with MERS-CoV: Analysis of publicly available data from Saudi Arabia date: 2016-01-25 words: 1668 flesch: 48 summary: The risk factors might vary geographically; additionally, the relatively small sample sizes in other studies could have missed other significant risk factors. Diabetes, hypertension, renal disease, malignancy, and several other conditions hitherto termed as miscellaneous conditions (e.g., anemia, obesity and congenital abnormalities, diseases of the liver and gall bladder, or steroid use) were significant risk factors for mortality from MERS-CoV (Table 1) . keywords: mers; risk cache: cord-259443-5sv3dwbs.txt plain text: cord-259443-5sv3dwbs.txt item: #53 of 515 id: cord-259658-rgrt6e6r author: Yan, Bingpeng title: Characterization of the Lipidomic Profile of Human Coronavirus-Infected Cells: Implications for Lipid Metabolism Remodeling upon Coronavirus Replication date: 2019-01-16 words: 5312 flesch: 34 summary: To investigate how coronavirus perturbs host lipid metabolism, we performed lipidomics analysis on HCoV-229E-infected Huh7 cells and compared the results with those of the mock-infected cells. Interestingly, exogenous supplement of LA or AA in HCoV-229E-infected cells significantly suppressed HCoV-229E virus replication. keywords: analysis; cells; coronavirus; figure; hcov-229e; human; infection; lipid; metabolism; pathway; replication cache: cord-259658-rgrt6e6r.txt plain text: cord-259658-rgrt6e6r.txt item: #54 of 515 id: cord-259703-9ef3u2mz author: Alsolamy, Sami title: Infection with Middle East respiratory syndrome coronavirus. date: 2015 words: 1275 flesch: 29 summary: Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical management of severe acute respiratory infection when Middle East respiratory syndrome coronavirus (MERS-CoV) infection is suspected -Interim guidance Hypoxaemic rescue therapies in acute respiratory distress syndrome: Why, when, what and which one? Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: For commercial reuse, contact reprints@pulsus.com Middle East respiratory syndrome coronavirus (MERS-CoV) -Saudi Arabia: Disease outbreak news Evidence for camelto-human transmission of MERS coronavirus Family cluster of Middle East respiratory syndrome coronavirus infections Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study MERS-CoV outbreak in Jeddah -a link to health care facilities Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Emerging human Middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: A report of nosocomial transmission Middle East respiratory syndrome: Knowledge to date Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia An appropriate lower respiratory tract specimen is essential for diagnosis of Middle East respiratory syndrome (MERS) keywords: cov; infection; mers; syndrome cache: cord-259703-9ef3u2mz.txt plain text: cord-259703-9ef3u2mz.txt item: #55 of 515 id: cord-260024-yrhlg6wm author: Ha, Kyoo-Man title: A lesson learned from the MERS outbreak in South Korea in 2015 date: 2015-10-24 words: 1419 flesch: 47 summary: What can we learn from MERS outbreak in South Korea? MERS viruses broke out in one hospital in Pyeongtaek, South Korea (hereinafter Korea), on May 2015, 2015. keywords: emergency; korea; mers; outbreak cache: cord-260024-yrhlg6wm.txt plain text: cord-260024-yrhlg6wm.txt item: #56 of 515 id: cord-260334-xo8ruswo author: New, R.R.C. title: Antibody-mediated protection against MERS-CoV in the murine model() date: 2019-07-09 words: 5762 flesch: 43 summary: Hospital outbreak of Middle East respiratory syndrome coronavirus Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans MERS-CoV origin and animal reservoir Novel betacoronavirus in dromedaries of the Middle East Middle East respiratory syndrome coronavirus (MERS-CoV): animal to human interaction Spiking the MERS-coronavirus receptor Crystal structure of the receptor-binding domain from newly emerged middle east respiratory syndrome coronavirus Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transduced mice from MERS-CoV infection Evaluation of candidate vaccine approaches for MERS-CoV Introduction of neutralising immunogenncity index to the rational design of MERS coronavirus sub-unit vaccines Recombinant receptor binding domain protein induces partial protective immunity in rhesus macaques against Middle East respiratory syndrome coronavirus challenge MERS-CoV spike protein: targets for vaccines and therapeutics Toward developing a preventive MERS-CoV vaccine-report from a workshop organized by the Saudi Arabia ministry of health and the international vaccine institute Protein coated microcrystals formulated with model antigens and modified with calcium phosphate exhibit enhanced phagocytosis and immunogenicity A new oil-based antigen delivery formulation for both oral and parenteral vaccination Reverse micelle-encapsulated recombinant baculovirus as an oral vaccine against H5N1 infection in mice Dual route vaccination for plague with emergency use applications Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Severe respiratory illness caused by a novel coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Real-time reverse transcription-PCR assay panel for middle east respiratory syndrome coronavirus Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate Subsequent challenge of the recipient transduced mice by the intra-nasal route with a clinical isolate of the MERS-CoV resulted in a significantly reduced viral load in their lungs, compared with transduced mice receiving a negative control antibody. keywords: cov; human; igg; mers; mice; murine; protein; rbd; route; s.c; specific; vaccine cache: cord-260334-xo8ruswo.txt plain text: cord-260334-xo8ruswo.txt item: #57 of 515 id: cord-260420-4s7akmdp author: Mubareka, Samira title: Bioaerosols and Transmission, a Diverse and Growing Community of Practice date: 2019-02-21 words: 4022 flesch: 17 summary: Ongoing research has also facilitated the development and dissemination of procedures and protocols for experimental work, including artificial aerosols, as well as animal models of transmission including the ferret model for influenza virus transmission and macaque model for Ebola virus transmission (34, 35) . The effect of environmental parameters on the survival of airborne infectious agents Exposure to influenza virus aerosols during routine patient care Influenza aerosols in UK hospitals during the H1N1 (2009) pandemicthe risk of aerosol generation during medical procedures Human viral pathogens are pervasive in wastewater treatment center aerosols Respiratory performance offered by N95 respirators and surgical masks: human subject evaluation with NaCl aerosol representing bacterial and viral particle size range Comparison of aerosol and bioaerosol collection on air filters Water and air ozone treatment as an alternative sanitizing technology Effect of different disinfectants on bacterial aerosol diversity in poultry houses Drivers of airborne human-to-human pathogen transmission Challenge of liquid stressed protective materials and environmental persistence of ebola virus. keywords: air; animal; bioaerosols; health; human; pathogens; potential; research; risk; sampling; transmission; virus cache: cord-260420-4s7akmdp.txt plain text: cord-260420-4s7akmdp.txt item: #58 of 515 id: cord-260518-mswb3q67 author: Zumla, Alimuddin title: Taking forward a ‘One Health’ approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential date: 2016-06-15 words: 4040 flesch: 36 summary: Since the Kingdom of Saudi Arabia is host to millions of pilgrims each year travelling from all continents, 29 tackling the threat of MERS and other infectious diseases with epidemic potential will require enhanced closer cooperation between those who provide human health, animal health, and environmental health services, locally, nationally, regionally, and internationally: the Middle Eastern, European, African, Asian, and American governments, veterinary groups, the WHO, the Food and Agriculture Organization (FAO), the African Union, the United Nations International Children's Emergency Fund (UNICEF), The World Bank, Office International des Epizooties (OIE), CDC, Public Health England, the newly formed Africa CDC, and funding agencies among others. However, MERS-CoV remains a major global public health threat with continuing reports of new human MERS cases in Saudi Arabia, where millions of pilgrims from over 184 countries travel throughout the year. keywords: animal; coronavirus; cov; east; health; human; mers; middle; respiratory; syndrome cache: cord-260518-mswb3q67.txt plain text: cord-260518-mswb3q67.txt item: #59 of 515 id: cord-261041-nrmj1qre author: Algaissi, Abdullah title: Evaluation of MERS-CoV Neutralizing Antibodies in Sera Using Live Virus Microneutralization Assay date: 2019-09-14 words: 2590 flesch: 64 summary: If using positive MERS-CoV sample, filter sterilize samples using Sterile 0.22 μm γ-irradiated syringe filters before inoculation onto Vero E6 cells (see Note 9). Vero E6 cells recover slowly after freezing and may take more than a week before they are ready to be passaged. keywords: cells; cov; culture; mers; virus cache: cord-261041-nrmj1qre.txt plain text: cord-261041-nrmj1qre.txt item: #60 of 515 id: cord-261163-n9tp9nx7 author: Ko, Jae-Hoon title: Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity date: 2017-10-31 words: 3148 flesch: 37 summary: The Cox proportional hazard model and logrank test were used to examine the association of seroconversion status with the 6-week mortality of MERS patients having pneumonia. Suggested new breakpoints of anti-MERS-CoV antibody ELISA titers: performance analysis of serologic tests Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Case definition and management of patients with MERS coronavirus in Saudi Arabia Antibodies against MERS coronavirus in dromedary camels Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity MERS coronavirus neutralizing antibodies in camels, eastern Africa Survival probability according to the seroconversion status was evaluated in MERS-CoV-infected patients having pneumonia, whose seroconversion status during the third week of illness is identifiable. keywords: group; mers; patients; seroconversion; week cache: cord-261163-n9tp9nx7.txt plain text: cord-261163-n9tp9nx7.txt item: #61 of 515 id: cord-261421-k1s5iy3u author: Khalafalla, Abdelmalik I. title: MERS-CoV in Upper Respiratory Tract and Lungs of Dromedary Camels, Saudi Arabia, 2013–2014 date: 2015-07-17 words: 3267 flesch: 42 summary: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Recovery from severe novel coronavirus infection Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia seroprevalence in domestic livestock in Saudi Arabia Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralization assays reveal a high prevalence of antibody in dromedary camels in Egypt Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Antibodies against MERS coronavirus in dromedary camels Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterization of assay specificity Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia MERS coronavirus in dromedary camel herd, Saudi Arabia MERS coronaviruses in dromedary camels A pancoronavirus RT-PCR assay for detection of all known coronaviruses Real-time reverse transcription polymerase chain reaction assay panel for Middle East respiratory syndrome coronavirus Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels MERS-CoV study group. To assess the temporal dynamics of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in dromedary camels, specimens were collected at 1–2 month intervals from 2 independent groups of animals during April 2013–May 2014 in Al-Ahsa Province, Saudi Arabia, and tested for MERS-CoV RNA by reverse transcription PCR. keywords: arabia; camels; coronavirus; cov; east; mers; saudi cache: cord-261421-k1s5iy3u.txt plain text: cord-261421-k1s5iy3u.txt item: #62 of 515 id: cord-261533-73721b24 author: Mok, Chris Ka Pun title: T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study date: 2020-10-06 words: 4834 flesch: 45 summary: Our findings suggest that the incidence of MERS infections taking place in Africa is underestimated. key: cord-261533-73721b24 authors: Mok, Chris Ka Pun; Zhu, Airu; Zhao, Jingxian; Lau, Eric H Y; Wang, Junxiang; Chen, Zhao; Zhuang, Zhen; Wang, Yanqun; Alshukairi, Abeer N; Baharoon, Salim A; Wang, Wenling; Tan, Wenjie; Liang, Weiwen; Oladipo, Jamiu O; Perera, Ranawaka A P M; Kuranga, Sulyman A; Peiris, Malik; Zhao, Jincun title: T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study date: 2020-10-06 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(20)30599-5 sha: doc_id: 261533 cord_uid: 73721b24 BACKGROUND: keywords: abattoir; cell; cov; dromedary; exposure; mers; responses; workers cache: cord-261533-73721b24.txt plain text: cord-261533-73721b24.txt item: #63 of 515 id: cord-261566-fn08b0y2 author: Mudgal, Rajat title: Prospects for mucosal vaccine: shutting the door on SARS-CoV-2 date: 2020-09-15 words: 7065 flesch: 27 summary: The genes encoding structural proteins, including spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins are present at 3ˊ end of genomic RNA. 7, 8 The S protein of coronaviruses is one of the most important targets for the development of SARS vaccines and therapeutics because it is involved in receptor recognition, as well as virus attachment and entry. key: cord-261566-fn08b0y2 authors: Mudgal, Rajat; Nehul, Sanketkumar; Tomar, Shailly title: Prospects for mucosal vaccine: shutting the door on SARS-CoV-2 date: 2020-09-15 journal: Human vaccines & immunotherapeutics DOI: 10.1080/21645515.2020.1805992 sha: doc_id: 261566 cord_uid: fn08b0y2 The sudden emergence of a highly transmissible and pathogenic coronavirus SARS-CoV-2 in December 2019 from China and its rapid global spread has posed an international health emergency. keywords: antigen; cells; coronavirus; cov; cov-2; development; immune; immunity; infection; mers; mucosal; protein; response; sars; syndrome; vaccine cache: cord-261566-fn08b0y2.txt plain text: cord-261566-fn08b0y2.txt item: #64 of 515 id: cord-261876-7rsc803x author: Kaslow, David C. title: Certainty of success: three critical parameters in coronavirus vaccine development date: 2020-05-25 words: 6468 flesch: 17 summary: As noted by Callow et al. 35 the human challenge data are consistent with the notion that adults have human coronavirus infections on a 2-3 year cyclic pattern and that protective amounts of antibody may have disappeared by 2 years, and that if we had been able to reinoculate the volunteers after a further year, the reinfection rate would have been even higher. In considering the “certainty of success” in development of human coronavirus vaccines, particularly SARS-CoV-2, a third, related critical parameter is proposed—infectious inoculum intensity, at an individual-level, and force of infection, at a population-level. keywords: certainty; coronavirus; cov-2; disease; human; incubation; infection; inoculum; period; response; sars; success; vaccine cache: cord-261876-7rsc803x.txt plain text: cord-261876-7rsc803x.txt item: #65 of 515 id: cord-262045-r2iqpmmc author: Smits, Saskia L. title: Reliable typing of MERS-CoV variants with a small genome fragment date: 2014-12-15 words: 2154 flesch: 44 summary: The continued occurrence of transmission between humans in health care and family settings is an ongoing concern as stated by the World Health Organization (http://www.who.int/csr/disease/coronavirus infections/MERS CoV Update 27 March 2014.pdf?ua=1), although the outbreaks appear to be self-limiting or extinguishable with rigorous implementation of appropriate infection control guidelines at present. State of knowledge and data gaps of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in humans Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels Antibodies against MERS coronavirus in dromedary camels Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Isolation of MERS coronavirus from a dromedary camel Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands This work was funded by ZonMW TOP project 91213058Z. keywords: analysis; coronavirus; cov; genome; human; mers cache: cord-262045-r2iqpmmc.txt plain text: cord-262045-r2iqpmmc.txt item: #66 of 515 id: cord-262542-vevsgkp6 author: Alharbi, Naif Khalaf title: ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice date: 2017-06-27 words: 4957 flesch: 45 summary: All vaccines contained the full-length spike gene of MERS-CoV; ChAdOx1 MERS vaccines were produced with or without the leader sequence of the human tissue plasminogen activator gene (tPA) where MVA MERS vaccines were produced with tPA, but either the mH5 or F11 promoter driving expression of the spike gene. For MVA MERS vaccines chicken embryo fibroblast cells (CEFs) were infected with MVA parental virus that encodes dsRed marker instead of the native F11L ORF and transfected with MVA shuttle plasmids containing MERS-CoV spike gene (explained above) to allow recombination with the MVA genome and deletion of dsRed marker whilst keeping the F11 promoter sequence. keywords: candidates; chadox1; coronavirus; cov; f11; mers; mh5; mva; promoter; syndrome; tpa; vaccine cache: cord-262542-vevsgkp6.txt plain text: cord-262542-vevsgkp6.txt item: #67 of 515 id: cord-262673-j2ot35lt author: Ahmed-Hassan, Hanaa title: Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections date: 2020-08-18 words: 8607 flesch: 21 summary: Furthermore, respiratory epithelial cells and lung macrophages are capable of secreting a broad range of chemokines like IL-8, Macrophage inflammatory protein-1 Interestingly, previous studies found rapid and significant restoration of lymphocyte subsets including, NK cells, in peripheral blood in patients recovering from the initial stages of SARS infection (249) . keywords: acute; cells; coronavirus; cov; cov-2; covid-19; disease; human; ifn; infection; influenza; lung; macrophages; mers; patients; response; role; sars; syndrome; type cache: cord-262673-j2ot35lt.txt plain text: cord-262673-j2ot35lt.txt item: #68 of 515 id: cord-263016-28znb322 author: Omrani, A.S. title: Middle East respiratory syndrome coronavirus (MERS-CoV): what lessons can we learn? date: 2015-08-22 words: 4493 flesch: 41 summary: What travel health advice should be given to Hajj pilgrims Preventive measures against MERS-CoV for Hajj pilgrims The Hajj pilgrimage and surveillance for Middle East respiratory syndrome coronavirus in pilgrims from African countries Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj From the Hajj: it's the flu, idiot High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Circulation of respiratory viruses among pilgrims during the 2012 Hajj pilgrimage Saudi Arabia, South Korea Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Lessons to learn from MERS-CoV outbreak in South Korea Spread of MERS to South Korea and China List of hospitals with known MERS exposure Preliminary data from sequencing of viruses in the Republic of Korea and the People's Republic of China. Archive Number Severe respiratory illness caused by a novel coronavirus First cases of Middle East respiratory syndrome coronavirus (MERS-CoV) investigations and implications for the prevention of human-to-human transmission A case of imported Middle East respiratory syndrome coronavirus infection and public health response Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Lack of transmission among close contacts of patient with case of Middle East respiratory syndrome imported into the United States Spread, circulation, and evolution of the Middle East keywords: camels; coronavirus; cov; east; human; infection; mers; middle; saudi; syndrome cache: cord-263016-28znb322.txt plain text: cord-263016-28znb322.txt item: #69 of 515 id: cord-263042-qdmunb9l author: Zhao, Yongkun title: Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model date: 2016-11-24 words: 3379 flesch: 44 summary: Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Transmission of MERS-coronavirus in household contacts Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays Towards improving clinical management of Middle East respiratory syndrome coronavirus infection Identification of a critical neutralization determinant of severe acute respiratory syndrome (SARS)-associated coronavirus: importance for designing SARS vaccines A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Passive immunotherapy for influenza A H5N1 virus infection with equine hyperimmune globulin F(ab')2 in mice Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies Severe acute respiratory syndrome Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaques Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Rapid generation of a mouse model for Middle East respiratory syndrome Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Treatment with hyperimmune equine immunoglobulin or immunoglobulin fragments completely protects rodents from Ebola virus infection Inhibition of infection caused by severe acute respiratory syndrome-associated coronavirus by equine neutralizing antibody in aged mice Middle East respiratory syndrome Ad5-hDPP4 transduced BALB/c mice (6wks, female) were injected intraperitoneally with 200 mL horse serum However, neutralizing antibody titers in MERS patients are generally low and the limited number of MERS survivors makes this approach impractical (Drosten et al., 2013) . keywords: antibodies; cov; igg; mers; mice; rbd cache: cord-263042-qdmunb9l.txt plain text: cord-263042-qdmunb9l.txt item: #70 of 515 id: cord-263391-18x4ann5 author: Harvey, Ruth title: Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus date: 2019-10-17 words: 3043 flesch: 36 summary: In this collaborative study, we evaluated the performance of assays to detect MERS-CoV antibodies using a panel of serologic samples. We describe a collaborative study to investigate the comparability of serologic assays for MERS-CoV and assess any benefit associated with the introduction of a standard reference reagent for MERS-CoV serology. keywords: assays; cov; health; laboratories; laboratory; mers; samples cache: cord-263391-18x4ann5.txt plain text: cord-263391-18x4ann5.txt item: #71 of 515 id: cord-263508-row2mn17 author: Chan, Jasper Fuk-Woo title: The emerging novel Middle East respiratory syndrome coronavirus: The “knowns” and “unknowns” date: 2013-07-21 words: 4349 flesch: 27 summary: Announcement of the Coronavirus Study Group Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Latest outbreak news from ProMED-mail: novel coronavirus e Middle East Recovery from severe novel coronavirus infection Evidence of person-to-person transmission within a family cluster of novel coronavirus infections Contact investigation of a case of human novel coronavirus infection treated in a German hospital World Health Organization. Geneva: WHO Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Crossreactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Laboratory capability for molecular detection and confirmation of novel coronavirus in Europe Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC Global alert and response (GAR): Middle East respiratory syndrome coronavirus (MERS-CoV) e update keywords: cases; coronavirus; cov; east; human; infection; mers; middle; novel; respiratory; sars cache: cord-263508-row2mn17.txt plain text: cord-263508-row2mn17.txt item: #72 of 515 id: cord-264199-8skyagsz author: Fragaszy, Ellen title: Emerging respiratory infections: influenza, MERS-CoV, and extensively drug-resistant tuberculosis date: 2014-12-31 words: 1050 flesch: 39 summary: After adjustment for treatment propensity and potential confounders, the results of their meta-analysis indicate that compared with no treatment, neuraminidase inhibitor treatment at any time during illness was associated with a reduction in mortality risk (adjusted odds ratio CPAP is still a mainstay of OSA treatment, but clinicians clearly now have a wider range of therapeutic options that one day might well be predicted by careful patient phenotyping. keywords: infl; patients; treatment; uenza cache: cord-264199-8skyagsz.txt plain text: cord-264199-8skyagsz.txt item: #73 of 515 id: cord-264267-weat0qs6 author: Kleine-Weber, Hannah title: Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus date: 2020-01-21 words: 7245 flesch: 41 summary: As DPP4 needs to be transported to the plasma membrane to be engaged by MERS-CoV S for host cell entry, we next investigated whether the presence of the polymorphic DPP4 residues has an impact on DPP4 cell surface localization. We identified four mutations that reduced MERS-CoV S binding to DPP4 and MERS-CoV S-driven host cell entry without affecting DPP4 expression at the cell surface. keywords: analysis; binding; cells; cov; cov s; dpp4; entry; expression; human; mers; pbs; polymorphisms; protein; residues cache: cord-264267-weat0qs6.txt plain text: cord-264267-weat0qs6.txt item: #74 of 515 id: cord-264408-vk4lt83x author: Ruiz, Sara I. title: Animal Models of Human Viral Diseases date: 2017-06-23 words: 34509 flesch: 38 summary: The severe acute respiratory syndrome severe acute respiratory syndrome Bacterial sinusitis and otitis media following influenza virus infection in ferrets Neuropathology of H5N1 virus infection in ferrets The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease Immunopathogenesis of coronavirus infections: implications for sArs Hantavirus pulmonary syndrome: the new American hemorrhagic fever rift Valley fever Inbred rat strains mimic the disparate human response to rift Valley fever virus infection experimental studies of arenaviral hemorrhagic fevers experimental rift Valley fever in rhesus macaques Bovine respiratory syncytial virus protects cotton rats against human respiratory syncytial virus infection Human Hendra virus encephalitis associated with equine outbreak Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virus structure as revealed by airway dissection. emerg Generation of a transgenic mouse model of Middle east respiratory syndrome coronavirus infection and disease Pathological changes in brain and other target organs of infant and weanling mice after infection with nonneuroadapted Western equine encephalitis virus Particle-to-PFU ratio of ebola virus influences disease course and survival in cynomolgus macaques Progress toward norovirus vaccines: considerations for further development and implementation in potential target populations Characterization of lethal Zika virus infection in AG129 mice experimental in vitro and in vivo models for the study of human hepatitis B virus infection A model of meningococcal bacteremia after respiratory superinfection in influenza A virus-infected mice Middle east respiratory syndrome coronavirus: current situation and travel-associated concerns Aerosol exposure to the Angola strain of marburg virus causes lethal viral hemorrhagic fever in cynomolgus macaques Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola Virus-Infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death American Academy of Pediatrics subcommittee on Diagnosis and Management of Bronchiolitis Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models The gerbil, Meriones unguiculatus, a model for rift Valley fever viral encephalitis Morbidity and mortality among patients with respiratory syncytial virus infection: a 2-year retrospective review Chikungunya and the nervous system: what we do and do not know The West Nile virus outbreak of 1999 in New York: the Flushing Hospital experience Hospital outbreak of Middle east respiratory syndrome coronavirus Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses Norovirus vaccine against experimental human Norwalk Virus illness Determination of the 50% human infectious dose for Norwalk virus An epizootic attributable to Western equine encephalitis virus infection in emus in Texas evidence for camel-to-human transmission of Mers coronavirus Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted rag2 −/− gamma c keywords: acute; aerosol; animal; animal model; cells; challenge; clinical; coronavirus; cov; cynomolgus; days; dengue; disease; encephalitis; et al; experimental; exposure; ferrets; fever; fever virus; guinea; hepatitis; human; infected; infection; infection model; influenza; influenza virus; inoculation; lethal; liver; macaques; mice; model; monkeys; mouse; mouse model; nhps; pathogenesis; pigs; replication; response; rhesus; route; sars; signs; strain; studies; study; symptoms; syndrome; transmission; vaccine; viral; viremia; virus; virus infection; viruses cache: cord-264408-vk4lt83x.txt plain text: cord-264408-vk4lt83x.txt item: #75 of 515 id: cord-264653-ms6zrrnd author: Bhatnagar, Tarun title: Lopinavir/ritonavir combination therapy amongst symptomatic coronavirus disease 2019 patients in India: Protocol for restricted public health emergency use date: 2020-04-28 words: 2715 flesch: 37 summary: Studies on MERS patients with treatment regimens including lopinavir-ritonavir reported positive disease outcomes including defervescence, viral clearance from serum and sputum and survival Initial virological and clinical findings MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Combination therapy with lopinavir/ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): keywords: combination; coronavirus; cov; covid-19; lopinavir; patients; ritonavir; treatment cache: cord-264653-ms6zrrnd.txt plain text: cord-264653-ms6zrrnd.txt item: #76 of 515 id: cord-264901-w285on4x author: Ahmadzadeh, Jamal title: The risk factors associated with MERS-CoV patient fatality: A global survey date: 2019-07-31 words: 2517 flesch: 49 summary: No molecular evidence of MERS-CoV circulation in Jeddah, Saudi Arabia between 2010-2012: a single-center retrospective study The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health Risk factors for Middle East respiratory syndrome coronavirus infection among healthcare personnel Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus Respiratory tract infection during hajj Hospital outbreak of Middle East respiratory syndrome coronavirus Role of severe acute respiratory syndrome coronavirus Viroporins E, 3a, and 8a in replication and pathogenesis MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Lack of nasal carriage of novel corona virus (HCoV-EMC) in French hajj pilgrims returning from the hajj 2012, despite a high rate of respiratory symptoms Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Hospital-associated Middle East respiratory syndrome coronavirus infections Bat origin of human coronaviruses Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Knowledge and practices regarding Middle East respiratory syndrome coronavirus among camel handlers in a slaughterhouse An update to middle east respiratory syndrome coronavirus and risk of a pandemic in 2019 Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Family cluster of Middle East respiratory syndrome coronavirus infections Etiology of severe community-acquired pneumonia during the 2013 hajj-part of the MERS-CoV surveillance program Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1. 2017 to 17.1. The characteristics and the number of MERS cases per year can be found in . keywords: cov; east; mers; middle; syndrome cache: cord-264901-w285on4x.txt plain text: cord-264901-w285on4x.txt item: #77 of 515 id: cord-264956-wbi0ird5 author: Ahmed, Anwar E. title: Development of a risk‐prediction model for Middle East respiratory syndrome coronavirus infection in dialysis patients date: 2018-04-14 words: 2584 flesch: 42 summary: MERS dialysis patients were more likely to have chest pain (OR 5 24.194; P 5 0.011), leukopenia (OR 5 6.080; P 5 0.049), and elevated AST (OR 5 11.179; P 5 0.013). The Youden index yielded a value of 0.439 or greater as the best cut‐off for high risk of MERS infection. keywords: cov; dialysis; infection; mers; model; patients cache: cord-264956-wbi0ird5.txt plain text: cord-264956-wbi0ird5.txt item: #78 of 515 id: cord-265128-i0d4lxko author: Gurung, Arun Bahadur title: Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 M(pro) enzyme through in silico approach date: 2020-05-22 words: 2236 flesch: 46 summary: The natural products such as traditional medicines and plant-derived compounds (phytochemicals) are the rich sources of promising antiviral drugs [14] . The binding energies and inhibition constants of the phytochemicals with the SARS-CoV-2 M pro enzyme were compared with that of a set of twelve FDA approved antiviral drugs-a) Viral SARS-CoV-2 and Coronavirus Disease 2019: keywords: coronavirus; cov; drug; enzyme; m(pro; mers; phytochemicals; sars cache: cord-265128-i0d4lxko.txt plain text: cord-265128-i0d4lxko.txt item: #79 of 515 id: cord-265279-0zjpqnqp author: Hoteit, Rouba title: Use of the Human Coronavirus 2012 (MERS) GeneSig kit for MERS-CoV detection date: 2016-04-16 words: 1961 flesch: 45 summary: To our knowledge, this is the first report that describes the clinical application of the GeneSig kit in the MERS-CoV epidemic era. Hospital-associated outbreak of Middle East Respiratory Syndrome Coronavirus: a serologic, epidemiologic, and clinical description Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Update: Severe respiratory illness associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-worldwide Transmission of MERS-coronavirus in household contacts Molecular pathology of emerging coronavirus infections Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities Middle East respiratory syndrome coronavirus (MERS-CoV) c WHO Infection control and MERS-CoV in health-care workers key: cord-265279-0zjpqnqp authors: Hoteit, Rouba; Shammaa, Dina; Mahfouz, Rami title: Use of the Human Coronavirus 2012 (MERS) keywords: coronavirus; cov; mers; rna cache: cord-265279-0zjpqnqp.txt plain text: cord-265279-0zjpqnqp.txt item: #80 of 515 id: cord-265282-v3n9ff16 author: Ahn, Inkyung title: Investigation of nonlinear epidemiological models for analyzing and controlling the MERS outbreak in Korea date: 2018-01-21 words: 4884 flesch: 45 summary: The impact of media on the control of infectious diseases When is quarantine a useful control strategy for emerging infectious diseases? Timely identification of optimal control strategies for emerging infectious diseases Deterministic and Stochastic Optimal Control Optimal control of epidemics Effects of quarantine in six endemic models for infectious diseases Optimal control methods applied to disease models Optimal control of treatments in a two-strain tuberculosis model Modeling Infectious Diseases in Humans and Animals Optimal control of the chemotherapy of HIV Amid panic, a chance to learn about MERS Optimal Control Applied to Biological Models Optimal Control Media/psychological impact on multiple outbreaks of emerging infectious diseases Ministry of Health and Welfare (MoH) and Center for Disease Control and Prevention MERS-CoV outbreak in jeddah-a link to health care facilities Chemotherapy for tumors: an analysis of the dynamics and a study of quadratic and linear optimal controls The Mathematical Theory of Optimal Processes Inference for nonlinear epidemiological models using genealogies and time series Effect of media-induced social distancing on disease transmission in a two patch setting Media impact switching surface during an infectious disease outbreak Control of epidemics by quarantine and isolation strategies in highly mobile populations Optimal quarantine and isolation strategies in epidemics control Isolation of a novel coronavirus from a man with pneumonia in saudi arabia Middle east respiratory syndrome This work was supported by a Korea University Grant. For this, the Hamiltonian H of the optimal control problem (8) is defined as and its costate equations can be obtained via 2 0 1 5 -0 5 -2 0 2 0 1 5 -0 5 -2 2 2 0 1 5 -0 5 -2 4 2 0 1 5 -0 5 -2 6 2 0 1 5 -0 5 -2 8 2 0 1 5 -0 5 -3 0 2 0 1 5 -0 6 -0 1 2 0 1 5 -0 6 -0 3 2 0 1 5 -0 6 -0 5 2 0 1 5 -0 6 -0 7 2 0 1 5 -0 6 -0 9 2 0 1 5 -0 6 -1 1 2 0 1 5 -0 6 -1 3 2 0 1 5 -0 6 -1 5 2 0 1 5 -0 6 -1 7 2 0 1 5 -0 6 -1 9 2 0 1 5 -0 6 -2 1 2 0 1 5 -0 6 -2 3 2 0 1 5 -0 6 -2 5 2 0 1 5 -0 6 -2 7 2 0 1 5 -0 6 -2 9 2 0 1 5 -0 7 -0 1 2 0 1 5 -0 7 -0 3 2 0 1 5 -0 7 -0 5 2 0 1 5 -0 7 -0 7 t 0 1000 2000 3000 4000 5000 6000 7000 S q (t) 2 0 1 5 -0 5 -2 0 2 0 1 5 -0 5 -2 2 2 0 1 5 -0 5 -2 4 2 0 1 5 -0 5 -2 6 2 0 1 5 -0 5 -2 8 2 0 1 5 -0 5 -3 0 2 0 1 5 -0 6 -0 1 2 0 1 5 -0 6 -0 3 2 0 1 5 -0 6 -0 5 2 0 1 5 -0 6 -0 7 2 0 1 5 -0 6 -0 9 2 0 1 5 -0 6 -1 1 2 0 1 5 -0 6 -1 3 2 0 1 5 -0 6 -1 5 2 0 1 5 -0 6 -1 7 2 0 1 5 -0 6 -1 9 2 0 1 5 -0 6 -2 1 2 0 1 5 -0 6 -2 3 2 0 1 5 -0 6 -2 5 2 0 1 5 -0 6 -2 7 2 0 1 5 -0 6 -2 9 2 0 1 5 -0 7 -0 1 2 0 1 5 -0 7 -0 3 2 0 1 5 -0 7 -0 5 From the optimality conditions, ∂H ∂ q * = 0 and ∂H ∂ θ * = 0 , we can also obtain the following condition for optimal control: Also, if upper bounds for the nonnegative control inputs are forced, then by confining the control input to be nonnegative and subject to a positive upper bound q max and θ max , the optimal control of (8) can be written in the following form: From the above steps, we can conclude that any solution to the optimal control problem (8) must satisfy the following: S(0) keywords: cases; control; mers; model; outbreak; quarantine; siq cache: cord-265282-v3n9ff16.txt plain text: cord-265282-v3n9ff16.txt item: #81 of 515 id: cord-265380-2gs34xcw author: Leist, Sarah R. title: Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome date: 2019-09-14 words: 6031 flesch: 46 summary: After infection mice are monitored daily for weight loss for the entire duration of the experiment. The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts Comparative analysis of eleven healthcare-associated outbreaks of Middle East respiratory syndrome coronavirus (Mers-Cov) from Economic impact of the 2015 MERS outbreak on the Republic of Korea's tourism-related industries Costly lessons from the 2015 Middle East respiratory syndrome coronavirus outbreak in Korea Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission Middle East respiratory syndrome coronavirus transmission among health care workers: implication for infection control MERS transmission and risk factors: a systematic review High prevalence of MERS-CoV infection in camel workers in Saudi Arabia Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Severe acute respiratory syndrome Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice Origin and evolution of pathogenic coronaviruses Jumping species-a mechanism for coronavirus persistence and survival Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection-clinicopathological and ultrastructural study Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Middle East respiratory syndrome Viral load kinetics of MERS coronavirus infection The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Lack of Middle East respiratory syndrome coronavirus transmission in rabbits Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Pneumonia from human coronavirus in a macaque model Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Infection with MERS-CoV causes lethal pneumonia in the common marmoset A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Middle East Respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with Middle East respiratory syndrome-coronavirus Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to Middle East respiratory syndrome coronavirus infection and disease CD8+ T cells and macrophages regulate pathogenesis in a mouse model of Middle East respiratory syndrome A human DPP4-Knockin Mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with Middle East respiratory syndrome coronavirus Haagmans BL (2013) keywords: coronavirus; cov; disease; east; fig; hdpp4; human; infection; mers; mice; middle; model; mouse; syndrome cache: cord-265380-2gs34xcw.txt plain text: cord-265380-2gs34xcw.txt item: #82 of 515 id: cord-265666-27ckjl7w author: Kang, Hee Sun title: Working experiences of nurses during the Middle East respiratory syndrome outbreak date: 2018-05-30 words: 3134 flesch: 53 summary: We made a package for MERS patients, a package for MERS. The hospitals rewarded working with MERS patients differently. keywords: care; mers; nurses; outbreak; participants; patients; syndrome cache: cord-265666-27ckjl7w.txt plain text: cord-265666-27ckjl7w.txt item: #83 of 515 id: cord-265769-96p07nyz author: Perlman, Stanley title: MERS-CoV in Africa—an enigma with relevance to COVID-19 date: 2020-10-06 words: 1064 flesch: 36 summary: Thus, zoonotic MERS-CoV infections of dromedary-exposed individuals are probably taking place in Nigeria, and, by extrapolation, the incidence of human MERS infections in all regions of Africa with dromedaries has probably been underestimated. World Health Organization From easing lockdowns to scaling-up community-based COVID-19 screening, testing, and contact tracing in Africa-shared approaches, innovations, and challenges to minimize morbidity and mortality Enzootic patterns of Middle East respiratory syndrome coronavirus in imported African and local Arabian dromedary camels: a prospective genomic study MERS-CoV in camels but not camel handlers T-cell responses to MERS coronavirus infection in people with occupational exposure to dromedary camels in Nigeria: an observational cohort study Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals Confronting the persisting threat of the Middle East respiratory syndrome to global health security We have a special interest in coronaviruses and infectious diseases with epidemic potential. keywords: africa; cov; mers cache: cord-265769-96p07nyz.txt plain text: cord-265769-96p07nyz.txt item: #84 of 515 id: cord-266031-tlrsco40 author: Haghani, Milad title: Covid-19 pandemic and the unprecedented mobilisation of scholarly efforts prompted by a health crisis: Scientometric comparisons across SARS, MERS and 2019-nCoV literature date: 2020-09-21 words: 8002 flesch: 43 summary: Covid-19 studies seem to have been disseminated across a broader variety of journals and across a more diverse range of subject areas. Covid-19 studies also display the involvement of authors from a broader variety of countries compared to SARS and MERS. keywords: cluster; coronavirus; covid-19; items; journal; literature; mers; number; publications; research; sars; studies cache: cord-266031-tlrsco40.txt plain text: cord-266031-tlrsco40.txt item: #85 of 515 id: cord-266253-oyid5haj author: Al-Abaidani, I.S. title: Overview of preparedness and response for Middle East respiratory syndrome coronavirus (MERS-CoV) in Oman date: 2014-10-29 words: 1113 flesch: 45 summary: The surveillance system for severe acute respiratory infections (SARI) was implemented in Oman in January 2008 in four regional hospitals as sentinel sites; SARI aims to determine the epidemiology of severe respiratory infections and the contribution of influenza and other etiological agents to severe respiratory infections in the country. Strengthened infection control practices and having a powerful active surveillance program for acute respiratory illnesses is key to the rapid and prompt response for emerging respiratory infections. keywords: cases; cov; mers cache: cord-266253-oyid5haj.txt plain text: cord-266253-oyid5haj.txt item: #86 of 515 id: cord-266260-t02jngq0 author: Ramshaw, Rebecca E. title: A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences date: 2019-12-13 words: 7243 flesch: 30 summary: Vector Borne Zoonotic Dis Arabia: an index case investigation Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Stillbirth During Infection With Middle East Respiratory Syndrome Coronavirus Antibodies against MERS Coronavirus in Dromedary Camels MERS-CoV Antibodies in Humans, Africa No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection Among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update Emergence of MERS-CoV in the Middle East: origins, transmission, treatment, and perspectives Laboratory-confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Malaysia: preparedness and response Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Asymptomatic MERS-CoV Infection in Humans Possibly Linked to Infected Dromedaries Imported from Oman to United Arab Emirates Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels The Middle East Respiratory Syndrome Coronavirus (MERS-COV) Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand Serologic Evidence for MERS-CoV Infection in Dromedary Camels Contact tracing the first Middle East respiratory syndrome case in the Philippines Effectiveness of the Middle East respiratory syndrome-coronavirus protocol in enhancing the function of an Emergency Department in Qatar High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Isolation of MERS coronavirus from a dromedary camel MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study MERS-CoV outbreak in Jeddah-a link to health care facilities A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS Acute Middle East Respiratory Syndrome Coronavirus: Temporal Lung Changes Observed on the Chest Radiographs of 55 Patients Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Antibody Response and Disease Severity in Healthcare Worker MERS Survivors Brief Report: Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a singlecenter experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Evidence for camel-to-human transmission of MERS coronavirus Exposures among MERS Case-Patients First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome Lack of middle East respiratory syndrome coronavirus transmission from infected camels Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East A cluster analysis with implications for global management of suspected cases Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Middle East respiratory syndrome coronavirus in children Middle East Respiratory Syndrome Coronavirus Infection During Pregnancy: A Report of 5 Cases From Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia Outbreak of Middle East Respiratory Syndrome at Tertiary Care Hospital Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Report of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in Four Patients with Hematological Malignancies Treated at King Fahad Medical City Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Healthcare Personnel Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report Surveillance and Testing for Middle East Respiratory Syndrome Coronavirus, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus transmission among health care workers: Implication for infection control Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Conveyance Contact Investigation for Imported Middle East Respiratory Syndrome Cases Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Outbreak of Middle East Respiratory Syndrome-Coronavirus Causes keywords: arabia; camels; case; coronavirus; cov; data; east; infection; mers; middle; middle east; outbreak; saudi; syndrome; syndrome coronavirus; transmission cache: cord-266260-t02jngq0.txt plain text: cord-266260-t02jngq0.txt item: #87 of 515 id: cord-266313-b518n9dx author: Cao, Yu-chen title: Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence date: 2020-04-02 words: 5557 flesch: 45 summary: bioRxiv; 2020 Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Pathological findings of COVID-19 associated with acute respiratory distress syndrome SARS-CoV-2 viral load in upper respiratory specimens of infected patients GS-5734) protects African green monkeys from Nipah virus challenge The antiviral compound remdesivir potently inhibits RNAdependent RNA polymerase from Middle East respiratory syndrome coronavirus Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection Nucleotide prodrug GS-5734 is a broad-spectrum filovirus inhibitor that provides complete therapeutic protection against the development of Ebola virus disease (EVD) in infected non-human primates Summaries of evidence from selected experimental therapeutics A randomized, controlled trial of Ebola virus disease therapeutics The pathogenesis of Ebola virus disease Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Nucleosides for the treatment of respiratory RNA virus infections The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures COVID-19 control in China during mass population movements at New Year Remdesivir as a possible therapeutic option for the COVID-19 Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides Travel Medicine and Infectious Disease xxx The 53% fatality rate was not significantly different from the average 50% fatality rate of Ebola virus infection, and as a result, phase II clinical trials were stopped. keywords: coronavirus; cov-2; covid-19; drug; ebola; infection; patients; remdesivir; sars; treatment; trials; virus cache: cord-266313-b518n9dx.txt plain text: cord-266313-b518n9dx.txt item: #88 of 515 id: cord-266464-wuf3s8m0 author: Kim, So Yeon title: Viral RNA in Blood as Indicator of Severe Outcome in Middle East Respiratory Syndrome Coronavirus Infection date: 2016-10-17 words: 1812 flesch: 42 summary: Blood viral RNA has been detected in a few case reports of MERS-CoV fatalities (8) (9) (10) . Our data of 42 specimens from cross-sectional time points focusing on early viremia showed that blood viral RNA was present in a subpopulation of patients and that these patients had significantly poorer prognoses, as demonstrated by the need for more frequent mechanical ventilation and the increased risk for death. keywords: blood; cov; mers; patients; rna; specimens cache: cord-266464-wuf3s8m0.txt plain text: cord-266464-wuf3s8m0.txt item: #89 of 515 id: cord-266987-ikt8r2o1 author: Loeffelholz, Michael J. title: Laboratory diagnosis of emerging human coronavirus infections – the state of the art date: 2020-03-30 words: 4745 flesch: 40 summary: The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A pneumonia outbreak associated with a new coronavirus of probable bat origin Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method The role of super-spreaders in infectious disease COVID-19: epidemiology, evolution, and cross-disciplinary perspectives Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Characteristics of COVID-19 infection in Beijing First case of 2019 novel coronavirus in the United States Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement Clinical characteristics of coronavirus disease 2019 in China Practical guidance for clinical microbiology laboratories: viruses causing acute respiratory tract infections Simple method for combining sputum and nasal samples for virus detection by reverse transcriptase PCR Detection of SARS-CoV-2 in different types of clinical specimens Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome Middle East respiratory syndrome coronavirus infection dynamics and antibody Responses among clinically Diverse patients, Saudi Arabia Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase Consistent detection of 2019 novel coronavirus in saliva Growth and intracellular development of a new respiratory virus Cultivation of a novel type of common-cold virus in organ cultures A highly specific rapid antigen detection assay for on-site diagnosis of MERS Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in SARS patients by enzymelinked immunosorbent assay Differentiation between human coronaviruses NL63 and 229E using a novel double-antibody sandwich enzyme-linked immunosorbent assay based on specific monoclonal antibodies Immunofluorescence assay for detection of the nucleocapsid antigen of the severe acute respiratory syndrome (SARS)-associated coronavirus in cells derived from throat wash samples of patients with SARS Comparison of immunofluorescence with monoclonal antibodies and RT-PCR for the detection of human coronaviruses 229E and OC43 in cell culture Evaluation of a commercial colloidal gold assay for detection of influenza A and B virus in children's respiratory specimens Rapid detection and monitoring of human coronavirus infections Examination of seroprevalence of coronavirus HKU1 infection with S protein-based ELISA and neutralization assay against viral spike pseudotyped virus Seroepidemiology of group I human coronaviruses in children Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak A new coronavirus associated with human respiratory disease in China Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study Co-infection with SARS-CoV-2 and influenza A virus in patient with pneumonia Laboratory diagnosis of respiratory tract infections in children -the State of the Art Molecular diagnosis of severe acute respiratory syndrome: the state of the art Emerging molecular assays for detection and characterization of respiratory viruses Molecular assays for the detection and characterization of respiratory viruses The dynamics of RNA shedding in MERS and SARS patients may reflect the specimen source, severity of illness, as well as underlying risk factors. keywords: cases; clinical; coronavirus; cov-2; detection; mers; novel; patients; pcr; respiratory; sars; specimens cache: cord-266987-ikt8r2o1.txt plain text: cord-266987-ikt8r2o1.txt item: #90 of 515 id: cord-267001-csgmc155 author: George, Parakkal Jovvian title: The Potency of an Anti-MERS Coronavirus Subunit Vaccine Depends on a Unique Combinatorial Adjuvant Formulation date: 2020-05-27 words: 7747 flesch: 42 summary: Importantly, we found a significant and positive correlation between the neutralizing antibody titers in sera of mice vaccinated with rASP-1 and the alum adjuvanted RBD vaccine separately and the fold increase in the frequency of TfH and GC B cells recruited in the draining LN ( Figures 4C and 5D) . Our findings not only indicate that this unique combinatorial adjuvanted RBD vaccine regimen improved the immunogenicity of RBD, but also point to the importance of utilizing combinatorial adjuvants for the induction of synergistic protective immune responses. keywords: adjuvant; alum; cells; cov; figure; inoculum; mers; mice; rasp-1; rbd; rbd vaccine cache: cord-267001-csgmc155.txt plain text: cord-267001-csgmc155.txt item: #91 of 515 id: cord-267090-jc1k3fki author: Gardner, Emma G. title: A case-crossover analysis of the impact of weather on primary cases of Middle East respiratory syndrome date: 2019-02-04 words: 4365 flesch: 45 summary: A case-crossover design was used to identify associations between primary MERS cases and preceding weather conditions within the 2-week incubation period in Saudi Arabia using univariable conditional logistic regression. A case-crossover design was used to explore the associations between primary MERS cases and preceding meteorological conditions [17, 26] . keywords: cases; cov; days; mers; odds; transmission; visibility; weather; wind cache: cord-267090-jc1k3fki.txt plain text: cord-267090-jc1k3fki.txt item: #92 of 515 id: cord-267333-8b7hvorz author: Watson, John T. title: Unraveling the Mysteries of Middle East Respiratory Syndrome Coronavirus date: 2014-06-17 words: 1355 flesch: 35 summary: respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV) Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus Close relative of human Middle East respiratory syndrome coronavirus in bat Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Antibodies against MERS coronavirus in dromedary camels MERS coronaviruses in dromedary camels, Egypt. Latest outbreak news from ProMED-mail: novel coronavirus-Middle East Middle East respiratory syndrome coronavirus (MERS-CoV)-update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update-as of 20 State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Family cluster of Middle East respiratory syndrome coronavirus infections Hospital outbreak of Middle East keywords: camels; coronavirus; cov; mers cache: cord-267333-8b7hvorz.txt plain text: cord-267333-8b7hvorz.txt item: #93 of 515 id: cord-267540-9p4rky4c author: Joseph, Iype title: Middle east respiratory syndrome corona virus (MERS CoV): The next steps date: 2015-03-26 words: 1708 flesch: 47 summary: Such hospital environments are quite common in developing countries. Health departments of developing countries can step forward to carry out this under international coordination from WHO. keywords: countries; cov; east; mers; middle cache: cord-267540-9p4rky4c.txt plain text: cord-267540-9p4rky4c.txt item: #94 of 515 id: cord-268388-kkhuzf3p author: Sharif-Yakan, Ahmad title: Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives date: 2014-12-04 words: 2508 flesch: 43 summary: A comparative serological study The emergence of the Middle East respiratory syndrome coronavirus (MERS-CoV) Middle east respiratory syndrome coronavirus: Epidemic potential or a storm in a teacup? Global Alert and Response: Middle East respiratory syndrome coronavirus (MERS-CoV) -update Middle east respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, qatar Middle east respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Middle east respiratory syndrome coronavirus in dromedary camels: An outbreak investigation Hospital outbreak of middle east respiratory syndrome coronavirus Interhuman transmissibility of middle east respiratory syndrome coronavirus: Estimation of pandemic risk Middle east respiratory syndrome coronavirus: Quantification of the extent of the epidemic, surveillance biases, and transmissibility Middle east respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Interim infection control and prevention recommendations for hospitalized patients with MERS-CoV MERS Case Definition MERS clinical update from the IDSA Center for Disease Control and Prevention CDC Epidemiological, demographic, and clinical characteristics of 47 cases of middle east respiratory syndrome coronavirus disease from saudi arabia: A descriptive study Clinical features and viral diagnosis of two cases of infection with middle east respiratory syndrome coronavirus: A report of nosocomial transmission Family cluster of middle east respiratory syndrome coronavirus infections A patient with severe respiratory failure caused by novel human coronavirus A family cluster of middle east respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Clinical features and virological analysis of a case of middle east respiratory syndrome coronavirus infection Epidemiological findings from a retrospective investigation WHO concludes MERS-CoV mission in Saudi Arabia MERS-CoV enigma deepens as reported cases surge Geographic distribution of MERS coronavirus among dromedary camels MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update as of 20 Prevalence of MERS-CoV nasal carriage and compliance with the saudi health recommendations among pilgrims attending the 2013 hajj Lack of MERS coronavirus but prevalence of influenza virus in french pilgrims after 2013 hajj The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development Proteolytic processing, deubiquitinase and interferon antagonist activities of middle east respiratory syndrome coronavirus papain-like protease What are our pharmacotherapeutic options for MERS-CoV? International Severe Acute Respiratory & Emerging Infection Consortium (ISARIC)-Clinical Decision Making Tool for Treatment of MERS-CoV v.1.1 An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Ribavirin and interferon therapy in patients infected with the middle east respiratory syndrome coronavirus: An observational study Repurposing of clinically developed drugs for treatment of middle east respiratory coronavirus infection The authors would like to acknowledge Sima L. Sharara for editing the manuscript. Emergence of a novel human coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update as of 26 Identification of a novel coronavirus in patients with severe acute respiratory syndrome Consensus document on the epidemiology of severe acute respiratory syndrome (SARS) Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Antibodies against MERS coronavirus in dromedary camels Replicative capacity of MERS coronavirus in livestock cell lines Middle east respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: keywords: coronavirus; cov; mers; middle; respiratory; syndrome cache: cord-268388-kkhuzf3p.txt plain text: cord-268388-kkhuzf3p.txt item: #95 of 515 id: cord-268483-joiajgs4 author: Shah, Vibhuti Kumar title: Overview of Immune Response During SARS-CoV-2 Infection: Lessons From the Past date: 2020-08-07 words: 10674 flesch: 31 summary: A randomized trial of hydroxychloroquine as postexposure prophylaxis for covid-19 Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Cinanserin is an inhibitor of the 3c-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro Inhibition of SARS-CoV 3CL protease by flavonoids Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Treatment with convalescent plasma for influenza A (H5N1) infection The convalescent sera option for containing COVID-19 Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 Effectiveness of convalescent plasma therapy in severe COVID-19 patients Use of convalescent plasma therapy in SARS patients in Hong Kong Available online at SARS vaccines: where are we? Neutralizing antibody against severe acute respiratory syndrome (SARS)-coronavirus spike is highly effective for the protection of mice in the murine SARS model SARS corona virus peptides recognized by antibodies in the sera of convalescent cases Severe acute respiratory syndrome (SARS) coronavirus: application of monoclonal antibodies and development of an effective vaccine Subunit vaccines against emerging pathogenic human coronaviruses Development of an inactivated vaccine candidate for SARS-CoV-2 ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Effects of toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine Neutralizing antibodies against SARS-CoV-2 and other human coronaviruses Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals A human monoclonal antibody blocking SARS-CoV-2 infection Identification of human single-domain antibodies against SARS-CoV-2 Microneedle array delivered recombinant coronavirus vaccines: immunogenicity and rapid translational development SARS-CoV-2 vaccines: status report Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies Mast cells contribute to coronavirus-induced inflammation: new anti-inflammatory strategy Clinical features of patients infected with 2019 novel coronavirus in Wuhan A phase 3, single-arm, prospective study of remestemcel-l, ex vivo culture-expanded adult human mesenchymal stromal cells for the treatment of pediatric patients who failed to respond to steroid treatment for acute graft-versus-host disease Remestemcel-L: Human mesenchymal stem cells as an emerging therapy for Crohn's disease Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia (2020) Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic People Who Are at Higher Risk for Severe Illness | Coronavirus | COVID-19 Severe acute respiratory syndrome-associated coronavirus in lung tissue Multiple organ infection and the pathogenesis of SARS SARS-CoV-2 Infection in Children Vulnerability of children with COVID-19 infection and ACE2 profiles in lungs Possible causes for decreased susceptibility of children to coronavirus Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and canadian pediatric intensive care units Outbreak of Kawasaki disease in children during COVID-19 pandemic: a prospective observational Features of COVID-19 post-infectious cytokine release syndrome in children presenting to the emergency department Links between innate and adaptive immunity via type I interferon Interferon and cytokine responses to SARScoronavirus infection SARS-CoV regulates immune function-related gene expression in human monocytic cells Profiles of antibody responses against severe acute respiratory syndrome coronavirus recombinant proteins and their potential use as diagnostic markers Early detection of antibodies against various structural proteins of the SARSassociated coronavirus in SARS patients Serological assays for emerging coronaviruses : challenges and pitfalls Profile of specific antibodies to the SARS-associated coronavirus T cell responses to whole SARS coronavirus in humans Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2 : an observational cohort study Profiling early humoral response to diagnose novel coronavirus disease (COVID-19) Viral kinetics and antibody responses in patients with COVID-19 Protective humoral immunity in SARS-CoV-2 infected pediatric patients The potential danger of suboptimal antibody responses in COVID-19 Medical countermeasures analysis of 2019-nCoV and vaccine risks for antibody-dependent enhancement (ADE) Antibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS Molecular mechanism for antibody-dependent enhancement of coronavirus entry Avoiding pitfalls in the pursuit of a COVID-19 vaccine Novel immunodominant peptide presentation strategy: a featured HLA-A * 2402-restricted cytotoxic t-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population Epidemiological and genetic correlates of severe acute respiratory syndrome coronavirus infection in the hospital with the highest nosocomial infection rate in Taiwan in 2003 Humanleukocyte antigen class keywords: acute; antibodies; antibody; cells; coronavirus; cov-2; covid-19; host; human; immune; infection; mers; novel; patients; protein; response; sars; study; syndrome; treatment cache: cord-268483-joiajgs4.txt plain text: cord-268483-joiajgs4.txt item: #96 of 515 id: cord-268943-arjtjy53 author: Reuss, Annicka title: Contact Investigation for Imported Case of Middle East Respiratory Syndrome, Germany date: 2014-04-17 words: 3059 flesch: 41 summary: These findings suggest these animals' possible relevance (e.g., as intermediate hosts) for human acquisition of MERS-CoV. Two complementary monitoring instruments for contact persons were used: active follow-up with daily telephone contact and a self-administered monitoring questionnaire. Such a questionnaire could be expanded to include a section for contact persons to fill in the names of persons with whom they had face-to-face contact during each day. keywords: contacts; coronavirus; cov; infection; mers; patient; person cache: cord-268943-arjtjy53.txt plain text: cord-268943-arjtjy53.txt item: #97 of 515 id: cord-269386-bnh65bqg author: Ko, Jae-Hoon title: Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak date: 2017-12-06 words: 1604 flesch: 36 summary: key: cord-269386-bnh65bqg authors: Ko, Jae-Hoon; Seok, Hyeri; Park, Ga Eun; Lee, Ji Yeon; Lee, Ji Yong; Cho, Sun Young; Ha, Young Eun; Kang, Ji-Man; Kim, Yae-Jean; Kang, Cheol-In; Chung, Doo Ryeon; Song, Jae-Hoon; Peck, Kyong Ran title: Host susceptibility to MERS-CoV infection, a retrospective cohort study of the 2015 Korean MERS outbreak date: 2017-12-06 journal: J Infect Chemother DOI: 10.1016/j.jiac.2017.09.008 sha: doc_id: 269386 cord_uid: bnh65bqg To evaluate host susceptibility factors to Middle East respiratory syndrome coronavirus (MERS-CoV) infection, we conducted a retrospective cohort study from the single largest exposure event of the 2015 Korean MERS outbreak. To identify host susceptibility factors to MERS-CoV infection, we performed a retrospective cohort study from the largest exposure event during the 2015 Korean MERS outbreak [3, 4] . keywords: cov; exposure; mers; patients cache: cord-269386-bnh65bqg.txt plain text: cord-269386-bnh65bqg.txt item: #98 of 515 id: cord-269437-0pvqvhqs author: Gastañaduy, Paul A. title: Update: Severe Respiratory Illness Associated with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) — Worldwide, 2012–2013 date: 2013-06-14 words: 1908 flesch: 40 summary: Severe respiratory illness associated with a novel coronavirus-Saudi Arabia and Qatar Novel coronavirus associated with severe respiratory disease: case definition and public health measures Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East Respiratory Syndrome Coronavirus (MERS-CoV); announcement of the Coronavirus Study Group Global Alert and Response (GAR): novel coronavirus infection -update (Middle East respiratory syndrome coronavirus) Updated rapid risk assessment: severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV) European Centre for Disease Prevention and Control. In addition, CDC recommends that clusters of severe acute respiratory illness be investigated and, if no obvious etiology is identified, local public health officials be notified and testing for MERS-CoV conducted, if indicated. keywords: cases; cov; mers; respiratory cache: cord-269437-0pvqvhqs.txt plain text: cord-269437-0pvqvhqs.txt item: #99 of 515 id: cord-269885-r8molh8c author: Jeong, Soo Young title: MERS-CoV Infection in a Pregnant Woman in Korea date: 2017-08-08 words: 1985 flesch: 46 summary: The effect of Asian influenza on the outcome of pregnancy MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Middle East Respiratory Syndrome Coronavirus (MERS-CoV) nosocomial outbreak in South Korea: insights from modeling Interim infection prevention and control recommendations for hospitalized patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Serologic evaluation of MERS screening strategy for healthcare personnel during a hospital-associated outbreak Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Characteristics and outcomes of Middle East Respiratory Syndrome Coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical presentation and outcomes of Middle East Respiratory Syndrome in the Republic of Korea MERS outbreak in Korea: hospital-to-hospital transmission Better understanding on MERS Corona Virus outbreak in Korea Case definition and management of patients with MERS Coronavirus in Saudi Arabia Impact of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) on pregnancy and perinatal outcome Middle East Respiratory Syndrome Coronavirus infection during pregnancy: a report of 5 cases from Saudi Arabia Middle East Respiratory Syndrome Coronavirus during pregnancy Stillbirth during infection with Middle East Respiratory Syndrome Coronavirus Transmission of MERS-coronavirus in household contacts Persistence of antibodies against Middle East Respiratory Syndrome Coronavirus Middle East Respiratory Syndrome Coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control The emergence of the Middle East Respiratory Syndrome Coronavirus We thank Dr. Christian Drosten and Dr. Marcel A. Muller in Institute of Virology, University of Bonn Medical Center for performing immunoglobulin A (IgA) enzyme-linked immunosorbent assay (ELISA) and plaque reduction neutralization test (PRNT). After a full recovery of MERS, the patient manifested abrupt vaginal bleeding with rupture of membrane. keywords: cov; east; infection; mers; middle; pregnancy cache: cord-269885-r8molh8c.txt plain text: cord-269885-r8molh8c.txt item: #100 of 515 id: cord-270077-mfl0iagr author: Chefer, Svetlana title: Modeling [(18)F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge date: 2015-11-16 words: 4491 flesch: 46 summary: Systemic factors such as viral proteins or cytokines could be engaged in lymphoid tissue response [7, 18] . (18)F-Fluorodeoxyglucose ([(18)F]-FDG)-positron emission tomography/computed tomography (PET/CT) as a longitudinal noninvasive approach can be beneficial in providing biomarkers for host immune response. keywords: cov; exposure; f]-fdg; fig; lns; mers; pet; response; uptake; virus cache: cord-270077-mfl0iagr.txt plain text: cord-270077-mfl0iagr.txt item: #101 of 515 id: cord-270258-9vgpphiu author: Ko, Jae-Hoon title: Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients date: 2016-08-09 words: 3461 flesch: 38 summary: World Health Organization Case definition and management of patients with MERS coronavirus in Saudi Arabia MERS-CoV outbreak in Jeddah e a link to health care facilities On estimating the relation between blood group and disease Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Treatment strategies for Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV), US CDC Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong White cell differential count and influenza A Thrombocytopenia in patients with severe acute respiratory syndrome (review) The clinical course of symptomatic MERS patients progressed serially: patients developed initial symptoms after a median 5-day incubation period (IQR 3.5e7.0), pneumonia after a median of 6 days from symptom onset (IQR 5.0e7.0), and respiratory failure after a median of 12 days from symptom onset (IQR 10.0e13.0). keywords: cov; development; factors; failure; mers; patients; pneumonia cache: cord-270258-9vgpphiu.txt plain text: cord-270258-9vgpphiu.txt item: #102 of 515 id: cord-270534-ebkwv4zo author: Bodmer, Bianca S. title: Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model date: 2018-06-11 words: 6556 flesch: 42 summary: In this study, we aimed to understand the induction of immunity and the functionality of induced T cell responses after vaccination with MV vac2 -MERS-S(H), a vaccine candidate that induces protective immunity against MERS-CoV in an appropriate animal model. In our study, the strong correlation of IFN-γ and TNF-α expression thus indicates a high functionality of induced T cell responses. keywords: antigen; cells; cov; ifn; mers; mice; responses; splenocytes; vac2; vaccine; virus cache: cord-270534-ebkwv4zo.txt plain text: cord-270534-ebkwv4zo.txt item: #103 of 515 id: cord-271004-gtmo5ixs author: Al-Tawfiq, Jaffar A. title: Influenza is more common than Middle East Respiratory Syndrome Coronavirus (MERS-CoV) among hospitalized adult Saudi patients date: 2017-10-12 words: 2645 flesch: 49 summary: 4. Interval plot of age and 95% confidence interval of age among influenza patients Hematologic, hepatic, and renal function changes in hospitalized patients with Middle East respiratory syndrome coronavirus Surveillance and testing for Middle East respiratory syndrome coronavirus Evaluation of patients under investigation for MERS-CoV infection Response to emergence of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Patterns of human respiratory viruses and lack of MERS-coronavirus in patients with acute upper respiratory tract infections in southwestern province of Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region Description of a hospital outbreak of Middle East respiratory syndrome in a large tertiary care hospital in Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study Influenza activity -United States, 2015-16 season and composition of the 2016-17 influenza vaccine Cross-Sectional survey and surveillance for influenza viruses and MERS-CoV among egyptian pilgrims returning from Hajj during 2012-2015 Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travellers and pilgrims from the Middle East: a prospective descriptive study for the period 2013-2015 Influenza not MERS CoV among returning Hajj and Umrah pilgrims with respiratory illness Hajj-associated viral respiratory infections: a systematic review Influenza A and B viruses but not MERS-CoV in Hajj pilgrims Laboratory testing for Middle East respiratory syndrome coronavirus Interim Guidelines for Clinical Specimens from PUI | CDC n The impact of coinfection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus Pandemic influenza A (2009 H1N1) in hospitalized patients in a Saudi Arabian hospital: epidemiology and clinical comparison with H1N1-negative patients Differences in clinical features between influenza A H1N1, A H3N2, and B in adult patients Clinical differences between influenza A (H1N1) pdm09 & influenza B infections identified through active community surveillance in North India Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Infections in symptomatic travelers returning from the Arabian peninsula to France: a retrospective cross-sectional study Enhanced MERS coronavirus surveillance of travelers from the Middle East to England Acute respiratory infections in travelers returning from MERS-CoV-affected areas All authors have no conflict of interest to declare. WHO Family cluster of Middle East respiratory syndrome coronavirus infections Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Recovery from severe novel coronavirus infection Saudi Ministry of Health C and CC. keywords: cov; east; influenza; mers; middle; patients cache: cord-271004-gtmo5ixs.txt plain text: cord-271004-gtmo5ixs.txt item: #104 of 515 id: cord-271211-frkk6w0a author: Han, Yu title: The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID‐19): A Chinese perspective date: 2020-03-12 words: 2116 flesch: 46 summary: The notice of launching guideline on diagnosis and treatment of COVID-19 Return of the coronavirus: 2019-nCoV Clinical and epidemiologic characteristics of spreaders of Middle East respiratory syndrome coronavirus during the 2015 outbreak in Korea A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Scientists are racing to model the next moves of a coronavirus that's still hard to predict Asymptomatic SARS coronavirus infection among healthcare workers MERS-CoV outbreak in Jeddah-a link to health care facilities Transmission of 2019-nCoV Infection from an asymptomatic contact in Germany Infectivity of an asymptomatic patient with Middle East respiratory syndrome coronavirus infection Zhang Wenhong, leader of Shanghai medical treatment expert panel: Studies have shown that SARS-CoV may be detected in the feces of most SARS patients, 15 and the virus within feces could survive at room temperature for at least 1 to 2 days. keywords: asymptomatic; coronavirus; cov-2; patients; sars; transmission cache: cord-271211-frkk6w0a.txt plain text: cord-271211-frkk6w0a.txt item: #105 of 515 id: cord-271244-6m8sbbi1 author: Bonilla-Aldana, D. Katterine title: SARS-CoV, MERS-CoV and now the 2019-novel CoV: Have we investigated enough about coronaviruses? – A bibliometric analysis date: 2020-02-29 words: 852 flesch: 46 summary: In conclusion, it is time to translate research findings into more effective measures, as with other priority diseases [7] , such as a vaccine or effective therapeutic options, aimed at controlling viruses with clear epidemic potential, and to prioritize those interventions, to reduce and control the negative impact of diseases such as those caused by CoV, including the new emerging 2019-nCoV. A systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus Origin and evolution of pathogenic coronaviruses List of Blueprint priority diseases SARS-CoV antibody prevalence in all Hong Kong patient contacts Lessons to learn from MERS-CoV outbreak in South Korea A novel coronavirus from patients with pneumonia in China Severe fever with thrombocytopenia syndrome -a bibliometric analysis of an emerging priority disease Ramírez-Ocampo Public Health and Infection Research and Incubator Group, Faculty of Health Sciences Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia The results of this study show that USA and China have primary roles in CoV research, with USA leading the scientific production with nearly a third of the articles (Fig. 1) . keywords: coronaviruses; cov; research cache: cord-271244-6m8sbbi1.txt plain text: cord-271244-6m8sbbi1.txt item: #106 of 515 id: cord-271504-t3y1w9ef author: Luo, Zichao title: Combating the Coronavirus Pandemic: Early Detection, Medical Treatment, and a Concerted Effort by the Global Community date: 2020-06-16 words: 14501 flesch: 38 summary: Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol New small-molecule drug design strategies for fighting resistant influenza A Characteristics of arbidol-resistant mutants of influenza virus: implications for the mechanism of anti-influenza action of arbidol Mechanism of inhibition of enveloped virus membrane fusion by the antiviral drug arbidol Membranotropic effects of arbidol, a broad antiviral molecule, on phospholipid model membranes Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment Discovering drugs to treat coronavirus disease 2019 (COVID-19) Effects of chloroquine on viral infections: an old drug against today's diseases Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology Chloroquine inhibits autophagic flux by decreasing autophagosomelysosome fusion New insights into the antiviral effects of chloroquine Anti-HIV effects of chloroquine: inhibition of viral particle glycosylation and synergism with protease inhibitors Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro Chloroquine is a potent inhibitor of SARS coronavirus infection and spread In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Effects of chronic exposure to hydroxychloroquine or chloroquine on inner retinal structures Animal toxicity and pharmacokinetics of hydroxychloroquine sulfate Retroviral proteases and their roles in virion maturation Host cell proteases: critical determinants of coronavirus tropism and pathogenesis Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts Research and development on therapeutic agents and vaccines for COVID-19 and related human coronavirus diseases Virusencoded proteinases and proteolytic processing in the Nidovirales The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry Protease inhibitors targeting coronavirus and filovirus entry Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective? Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity Recent research by Hoffmann et al. showed a promising in vitro inhibitory effect of this serine protease inhibitor in SARS-CoV and 2019-nCoV on human lung cells, showing potential as a viable option for COVID-19 treatment [113] . keywords: amplification; antibodies; antiviral; cells; china; chloroquine; coronavirus; covid-19; crispr; detection; disease; dna; drug; genome; host; infection; lamp; mers; ncov; novel; nucleic; patients; pcr; potential; protease; protein; rna; sars; syndrome; therapeutic; treatment cache: cord-271504-t3y1w9ef.txt plain text: cord-271504-t3y1w9ef.txt item: #107 of 515 id: cord-271512-owidim7o author: Thabet, Farah title: Middle East respiratory syndrome coronavirus in children date: 2015 words: 1463 flesch: 48 summary: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) update World Health Organization Middle East respiratory syndrome coronavirus disease in children Middle East respiratory syndrome coronavirus (MERS-CoV) -update World Health Organization Middle East respiratory syndrome coronavirus (MERS-CoV) -update World Health Organization Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study key: cord-271512-owidim7o authors: Thabet, Farah; Chehab, May; Bafaqih, Hind; AlMohaimeed, Sulaiman title: Middle East respiratory syndrome coronavirus in children date: 2015 journal: Saudi Med J DOI: 10.15537/smj.2015.4.10243 sha: doc_id: 271512 cord_uid: owidim7o The Middle East respiratory syndrome (MERS) is a new human disease caused by a novel coronavirus (CoV). keywords: coronavirus; cov; mers; syndrome cache: cord-271512-owidim7o.txt plain text: cord-271512-owidim7o.txt item: #108 of 515 id: cord-271648-m2c5bvuj author: Ashour, Hossam M. title: Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks date: 2020-03-04 words: 7550 flesch: 53 summary: Implications for virus origins and receptor binding Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2 Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) That sort of adaptation required a set of amino acid changes in the RBD of S protein of SARS viruses that were circulating in bats [65] . keywords: china; coronavirus; cov; cov-2; covs; human; mers; outbreak; protein; sars; syndrome; viruses cache: cord-271648-m2c5bvuj.txt plain text: cord-271648-m2c5bvuj.txt item: #109 of 515 id: cord-271681-jmoyy8rb author: Assiri, Abdullah M. title: Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia date: 2016-06-14 words: 4376 flesch: 40 summary: Specimens and Molecular Testing at the MoH Respiratory specimens, including nasopharyngeal and oral pharyngeal swabs, both separate and combined, nasopharyngeal and tracheal aspirates, and sputa collected from suspected MERS cases were tested at MOH laboratories by upE and ORF1a rRT-PCR assays key: cord-271681-jmoyy8rb authors: Assiri, Abdullah M.; Midgley, Claire M.; Abedi, Glen R.; Saeed, Abdulaziz Bin; Almasri, Malak M.; Lu, Xiaoyan; Al-Abdely, Hail M.; Abdalla, Osman; Mohammed, Mutaz; Algarni, Homoud S.; Alhakeem, Raafat F.; Sakthivel, Senthilkumar K.; Nooh, Randa; Alshayab, Zainab; Alessa, Mohammad; Srinivasamoorthy, Ganesh; AlQahtani, Saeed Yahya; Kheyami, Ali; HajOmar, Waleed Husein; Banaser, Talib M.; Esmaeel, Ahmad; Hall, Aron J.; Curns, Aaron T.; Tamin, Azaibi; Alsharef, Ali Abraheem; Erdman, Dean; Watson, John T.; Gerber, Susan I. title: Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia date: 2016-06-14 journal: Journal of Infectious Diseases DOI: 10.1093/infdis/jiw236 sha: doc_id: 271681 cord_uid: jmoyy8rb BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. keywords: arabia; cases; coronavirus; cov; east; mers; middle; nrc-2015; recombination; saudi; syndrome cache: cord-271681-jmoyy8rb.txt plain text: cord-271681-jmoyy8rb.txt item: #110 of 515 id: cord-271723-8qoozmgk author: Gelman, Ram title: Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents date: 2020-06-18 words: 6279 flesch: 30 summary: Like other coronaviruses, SARS-CoV-2 uses the S protein as the main interacting protein with host cell receptors, including the SARS-CoV receptor ACE2 for entry, and the serine protease TMPRSS2 for S protein priming [16] . The process of entry into a host cell is important for the life cycle of most viruses, and broad-spectrum antiviral approaches which target host cell proteins and pathways are being used. keywords: ace2; cells; coronavirus; cov-2; covid-19; disease; dpp4; drug; grp78; immune; protein; receptor; resistance; response; sars cache: cord-271723-8qoozmgk.txt plain text: cord-271723-8qoozmgk.txt item: #111 of 515 id: cord-272306-92rz2byz author: Morra, Mostafa Ebraheem title: Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta‐analysis date: 2018-04-17 words: 2496 flesch: 38 summary: Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Family cluster of Middle East respiratory syndrome coronavirus infections Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Treatment with interferon-[alpha] 2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration Case report guidelines The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses Meta-analysis in clinical trials Measuring inconsistency in meta-analyses Meta-analysis of genetic association studies Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches Post-dengue acute disseminated encephalomyelitis: a case report and meta-analysis MERS CoV infection in two renal transplant recipients: case report Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection A patient with severe respiratory failure caused by novel human coronavirus Ribavirin and interferon-alpha2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Middle East respiratory syndrome coronavirus in children Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Infection prevention/control and management guidelines for patients with Middle East respiratory syndrome coronavirus (MERS CoV) infection Severe acute respiratory syndrome vs. the Middle East respiratory syndrome Clinical outcomes of current medical approaches for Middle East respiratory syndrome: A systematic review and meta-analysis MERS surges again, but pandemic jitters ease Middle East respiratory syndrome coronavirus (MERS-CoV) keywords: coronavirus; east; mers; middle; studies; syndrome; treatment cache: cord-272306-92rz2byz.txt plain text: cord-272306-92rz2byz.txt item: #112 of 515 id: cord-272622-2wceu3o9 author: Park, Mi Hye title: Emergency cesarean section in an epidemic of the middle east respiratory syndrome: a case report date: 2016-06-01 words: 2175 flesch: 49 summary: Diagnosis, management and maternal-fetal prognosis: a retrospective study of 100 cases Mode of anaesthetic for category 1 caesarean sections and neonatal outcomes Anesthetic practice for Caesarean section and factors influencing anesthesiologists' choice of anesthesia: a population-based study Infection control measures for operative procedures in severe acute respiratory syndromerelated patients Lack of Transmission among Close Contacts of Patient with Case of Middle East Respiratory Syndrome Imported into the United States Severe acute respiratory syndrome in pregnancy Infants born to mothers with severe acute respiratory syndrome Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) Conversion of operating theatre from positive to negative pressure environment N95 respirator use during advanced pregnancy Acute and chronic respiratory diseases in pregnancy: associations with placental abruption Park et al. Early and strict infection control strategies and clinical guidelines for infectious patients, such as those with MERS, should be established. keywords: mers; operating; patient; room; sec cache: cord-272622-2wceu3o9.txt plain text: cord-272622-2wceu3o9.txt item: #113 of 515 id: cord-272710-uq2idlca author: Cho, Chao-Cheng title: Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Is an Efficient ADP-ribose Binding Module: CRYSTAL STRUCTURE AND BIOCHEMICAL STUDIES date: 2016-01-05 words: 4150 flesch: 44 summary: Structural studies of macro domains from CoVs such as human CoV 229E (HCoV-229E) and feline CoV (FCoV) also revealed interactions with ADP-ribose (41) (42) (43) and have offered huge advances in our understanding of viral macro domains. We reviewed the results of previously reported binding assays of ADP-ribose binding to CoV macro domains ( Table 2) . keywords: adp; binding; coronavirus; cov; domain; macro; mers; protein; ribose; structure; syndrome cache: cord-272710-uq2idlca.txt plain text: cord-272710-uq2idlca.txt item: #114 of 515 id: cord-272932-devmy5yx author: WANG, Wen Ling title: Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015 date: 2016-03-31 words: 2124 flesch: 50 summary: Many laboratory tests-such as immunofluorescence assays, ELISA, microneutralization assays and real-time RT-PCR assays-have been used to confirm MERS-CoV infection in MERS patients and their close contacts South Korea experienced a MERS outbreak representing the largest cluster of MERS cases outside the Middle East. keywords: contacts; cov; mers; patient; samples; serum cache: cord-272932-devmy5yx.txt plain text: cord-272932-devmy5yx.txt item: #115 of 515 id: cord-273182-djb0ozrt author: Díez, José María title: Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins date: 2020-09-09 words: 4331 flesch: 41 summary: Neutralizing antibodies against SARS-CoV-2 and other human coronaviruses Identification of the receptor-binding domain of the spike glycoprotein of human betacoronavirus HKU1 Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding SARS-CoV-2, SARS-CoV, and MERS-COV: a comparative overview Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop An outbreak of human coronavirus OC43 infection and serological cross-reactivity with SARS coronavirus. A report to understand the key role of antibody cross-reactivity in emerging viral disease Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43 • A report to understand the key role of antibody cross-reactivity in emerging viral disease Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens time report of significant cross-reactivity of currently available IVIG products to components of severe acute respiratory syndrome coronavirus 2 (CoV-2), severe acute respiratory syndrome CoV and Middle East respiratory syndrome-CoV Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis Search for SARS-CoV-2 inhibitors in currently approved drugs to tackle COVID-19 pandemia Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by SARS coronavirus and human coronavirus 229E The life cycle of SARS coronavirus in Vero E6 cells Polyclonal intravenous immunoglobulin for the prophylaxis and treatment of infection in critically ill adults. keywords: antibodies; coronavirus; cov; cov-2; cross; human; ivig; mers; neutralization; reactivity; sars cache: cord-273182-djb0ozrt.txt plain text: cord-273182-djb0ozrt.txt item: #116 of 515 id: cord-273391-vmtfn78x author: Li, Kun title: Single-Dose, Intranasal Immunization with Recombinant Parainfluenza Virus 5 Expressing Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Spike Protein Protects Mice from Fatal MERS-CoV Infection date: 2020-04-07 words: 5351 flesch: 46 summary: The prime-boost regimen of MVA (Modified Vaccinia Ankara) expressing MERS S protein induced neutralizing antibodies and T cell responses in mice and limited viral replication after challenge in mice and camels. The prime-boost regimen of measles virus (MV) expressing MERS S or soluble S induced both humoral and cellular immune responses. keywords: cells; challenge; cov; fig; immunization; mers; mice; pfu; piv5; protein; vaccine; virus cache: cord-273391-vmtfn78x.txt plain text: cord-273391-vmtfn78x.txt item: #117 of 515 id: cord-273626-zy8qjaai author: Gong, Shu‐ran title: The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models date: 2018-07-28 words: 3259 flesch: 45 summary: Regarding priorities for research on vaccines and antivirals for both coronaviruses, suitable MERS-CoV models should be considered first. 12M-006), the Chinese National Major S & T Project Wild animal surveillance for coronavirus HKU1 and potential variants of other coronaviruses Prevalence and genetic diversity of coronaviruses in bats from China Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Discovery of a rich gene pool of bat SARS related coronaviruses provides new insights into the origin of SARS coronavirus Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syn Rooting the phylogenetic tree of middle east respiratory syndrome coronavirus by characterization of a Conspecific virus from an African Bat Re-emerging Middle East respiratory syndrome coronavirus: The hibernating bat hypothesis Possible role of an animal vector in the SARS outbreak at Amoy Gardens Prevalence of IgG antibody to SARS-associated coronavirus in animal traders Civets are equally susceptible to experimental infection by two different severe acute respiratory syndrome Coronavirus isolates Comments to the predecessor of human SARS coronavirus in 2003-2004 epidemic Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Pneumonia from human coronavirus in a macaque model Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS Coronavirus Macaque Model for Severe Acute Respiratory Syndrome An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus Treatment With Lopinavir/Ritonavir or Interferon-b1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset Infection with MERS-CoV Causes Lethal Pneumonia in the Common Marmoset Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Pneumonitis and multiorgan system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirus Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of Mice Aged BALB/c Mice as a model for increased severity of severe acute respiratory syndrome in elderly humans Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian Hamsters Pathology of experimental SARS coronavirus infection in cats and ferrets Animal models for SARS Studies of severe acute respiratory syndrome coronavirus pathology in human cases and animal models Infection, replication, and transmission of middle east respiratory syndrome Coronavirus in Alpacas Replicative Capacity of MERS Coronavirus in Livestock Cell Lines Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting Phylogenetic perspectives on the epidemiology and origins of SARS and SARS-like coronaviruses How to cite this article: Gong SR, Bao LL. key: cord-273626-zy8qjaai authors: Gong, Shu‐ran; Bao, Lin‐lin title: The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models date: 2018-07-28 journal: keywords: animal; coronavirus; cov; infection; mers; models; sars; syndrome cache: cord-273626-zy8qjaai.txt plain text: cord-273626-zy8qjaai.txt item: #118 of 515 id: cord-273893-3nd6ptrg author: Lu, Guangwen title: Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 date: 2013-07-07 words: 4682 flesch: 50 summary: By a pairwise comparison, we unexpectedly found that all those CD26 residues identified in the virus-receptor interface are also involved in ADA binding, indicating a competition between ADA and the virus for CD26 receptor. The complex structure was solved by molecular replacement module of Phaser 33 , with the solved RBD structure and previously reported CD26 structure (PDB code, 2BGR) as the search models. keywords: binding; cd26; complex; coronavirus; cov; cov rbd; fig; mers; protein; rbd; receptor; sars; structure cache: cord-273893-3nd6ptrg.txt plain text: cord-273893-3nd6ptrg.txt item: #119 of 515 id: cord-274007-zndtddty author: Rasmussen, Sonja A. title: Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know date: 2020-02-24 words: 5921 flesch: 46 summary: Available at: https:// Expert Review ajog.org www.who.int/emergencies/diseases/novelcoronavirus-2019 Severe acute respiratory syndrome-related coronavirus: the species and its viruses-a statement of the Coronavirus Study Group Severe acute respiratory syndrome: Historical, epidemiologic, and clinical features the role of superspreaders in infectious disease Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome Infants born to mothers with severe acute respiratory syndrome SARS in newborns and children Emergency cesarean section in an epidemic of the middle east respiratory syndrome: a case report A casecontrolled study comparing clinical course and outcomes of pregnant and non-pregnant women with severe acute respiratory syndrome SARS and pregnancy: a case report SARS during pregnancy, United States Severe acute respiratory syndrome in pregnancy Specific immunoglobulin g antibody detected in umbilical blood and amniotic fluid from a pregnant woman infected by the coronavirus associated with severe acute respiratory syndrome Possible central nervous system infection by SARS coronavirus The effect of Severe Acute Respiratory Syndrome on a hospital obstetrics and gynaecology service Managing obstetrical patients during severe acute respiratory syndrome outbreak First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Middle East respiratory syndrome (MERS) For severe acute respiratory syndrome, the largest series of 12 pregnancies had a case-fatality rate of 25%. keywords: cases; coronavirus; covid-19; infection; mers; patients; pregnancy; sars; syndrome; transmission; women cache: cord-274007-zndtddty.txt plain text: cord-274007-zndtddty.txt item: #120 of 515 id: cord-274122-n9jnu2ah author: Mielech, Anna M. title: MERS-CoV papain-like protease has deISGylating and deubiquitinating activities date: 2014-02-01 words: 4861 flesch: 43 summary: Importantly, we show that coronavirus PLpro activity can modulate the innate immune response. We recently described expression and protease activity of MERS-CoV PLpro in cell culture (Kilianski et al., 2013) . keywords: activity; cells; coronavirus; cov; et al; mers; plpro; protease; sars; syndrome cache: cord-274122-n9jnu2ah.txt plain text: cord-274122-n9jnu2ah.txt item: #121 of 515 id: cord-274480-aywdmj6o author: Song, Wenfei title: Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry date: 2014-10-21 words: 2820 flesch: 49 summary: RBD D539 has salt-bridge interaction with hDPP4 residue K267 (B). However, the surrounding hydrophilic surface consists of RBD residues D510, E513 and Y540, and DPP4 residues H298, R317 and Q344. keywords: binding; cov; entry; hdpp4; mers; patch; rbd; residues cache: cord-274480-aywdmj6o.txt plain text: cord-274480-aywdmj6o.txt item: #122 of 515 id: cord-274506-fzcuu4ma author: Jo, Seri title: Characteristics of flavonoids as potent MERS‐CoV 3C‐like protease inhibitors date: 2019-09-12 words: 4240 flesch: 46 summary: A F I G U R E 4 Comparison of inhibitory activity between homologue flavonoids. Among them, herbacetin (3,4′,5,7,8-Pentahydroxyflavone), isobavachalcone (2′,4,4′-Trihydroxy-3′-(3-methyl-2-butenyl)chalcone), quercetin 3-β-d-glucoside (3,3′,4′,5,7-Pentahydroxyflavone 3-β-d-glucoside) and helichrysetin (4,2′,4′-trihydroxy-6′methoxychalcone) were found to have prominent inhibitory activity (Figure 2 ). keywords: 3clpro; activity; binding; compounds; cov; flavonoids; fluorescence; mers; protease cache: cord-274506-fzcuu4ma.txt plain text: cord-274506-fzcuu4ma.txt item: #123 of 515 id: cord-275138-033r259v author: Hayden, Frederick G title: Towards improving clinical management of Middle East respiratory syndrome coronavirus infection date: 2014-07-31 words: 1624 flesch: 30 summary: ISARIC has collaborated with WHO to develop biological sampling protocols that are applicable for patients with MERS-CoV. Furthermore, working with colleagues in Public Health England, ISARIC experts have examined available data and ranked potential therapeutic options with regard to their priority for clinical study; 10 this information will be updated as new data become available. key: cord-275138-033r259v authors: Hayden, Frederick G; Farrar, Jeremy; Peiris, J S Malik title: Towards improving clinical management of Middle East respiratory syndrome coronavirus infection date: 2014-07-31 journal: The Lancet Infectious Diseases DOI: 10.1016/s1473-3099(14)70793-5 sha: doc_id: 275138 cord_uid: 033r259v nan A decade on from the 2002-03 outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV) infections, the world is again confronted by the possible international spread of a novel coronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV), which apparently originated in the Arabian peninsula. keywords: cov; human; mers; polio; respiratory cache: cord-275138-033r259v.txt plain text: cord-275138-033r259v.txt item: #124 of 515 id: cord-275216-dnt88ycw author: Zhang, Xue-Yan title: Biological, clinical and epidemiological features of COVID-19, SARS and MERS and AutoDock simulation of ACE2 date: 2020-07-20 words: 4910 flesch: 46 summary: The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health -The latest 2019 novel coronavirus outbreak in Wuhan, China SARS and MERS: recent insights into emerging coronaviruses Preliminary prediction of the basic reproduction number of the Wuhan novel coronavirus 2019-nCoV The battle against SARS and MERS coronaviruses: Reservoirs and Animal Models The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts Applications of google search trends for risk communication in infectious disease management: a case study of COVID-19 outbreak in Taiwan Geographical tracking and mapping of coronavirus disease COVID-19/severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic and associated events around the world: how 21st century GIS technologies are supporting the global fight against outbreaks and epidemics Clinical trial analysis of 2019-nCoV therapy registered in China Retracted: clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and gag Broad Spectrum antiviral agent Niclosamide and its therapeutic potential Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Patients of COVID-19 may benefit from sustained lopinavir-combined regimen and the increase of eosinophil may predict the outcome of COVID-19 progression Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2 COVID-19: gastrointestinal manifestations and potential fecal-oral transmission Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes Acknowledgments AJE edited the manuscript for grammar, punctuation and spelling. Transmission route Viruses can directly infect people but can also infect one or more kinds of animals. keywords: coronavirus; cov-2; covid-19; epidemic; mers; novel; outbreak; patients; sars; transmission; treatment cache: cord-275216-dnt88ycw.txt plain text: cord-275216-dnt88ycw.txt item: #125 of 515 id: cord-275313-mfyff9ne author: Modjarrad, Kayvon title: Treatment strategies for Middle East respiratory syndrome coronavirus date: 2016-01-01 words: 3779 flesch: 32 summary: Epidemiological update: Middle East respiratory syndrome coronavirus (MERS-CoV) From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia County Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Human-dromedary camel interactions and the risk of acquiring zoonotic Middle East respiratory syndrome coronavirus infection Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Evidence for camel-to-human transmission of MERS coronavirus Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Transmission among healthcare worker contacts with a Middle East respiratory syndrome patient in a single Korean centre Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Health-care associate transmission of Middle East Respiratory Syndrome Corona virus, MERS-CoV, in the Kingdom of Saudi Arabia Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach Estimation of MERS-coronavirus reproductive number and case fatality rate for the Spring 2014 Saudi Arabia outbreak: insights from publicly available data Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Treatment with interferon-alpha2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Combination therapy with lopinavir/ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report Ribavirin and interferon-alpha2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Oral ribavirin for the treatment of noninfluenza respiratory viral infections: a systematic review Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis The use of convalescent plasma to treat emerging infectious diseases: focus on Ebola virus disease A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Towards the prophylactic and therapeutic use of human neutralizing monoclonal antibodies for Middle East respiratory syndrome coronavirus (MERS-CoV) Evaluation of candidate vaccine approaches for MERS-CoV Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Nucleotide prodrug GS-5734 is a broad-spectrum filovirus inhibitor that providescomplete therapeutic protection against the development of Ebola virus disease (EVD) in infected non-human primates ID Week BioCryst announces Nature publication demonstrating efficacy of BCX4430 in a non-human primate model of filovirus infection Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus Design of potential RNAi (miRNA and siRNA) molecules for Middle East respiratory syndrome coronavirus (MERS-CoV) gene silencing by computational method Antiviral drugs specific for coronaviruses in preclinical development A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs Most recently, Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a novel cause of severe acute respiratory illness after first being identified in a Saudi Arabian patient in 2012 keywords: clinical; coronavirus; cov; disease; east; human; mers; middle; syndrome; treatment cache: cord-275313-mfyff9ne.txt plain text: cord-275313-mfyff9ne.txt item: #126 of 515 id: cord-275404-hv3y4x4g author: Zumla, Alimuddin title: Infection control and MERS-CoV in health-care workers date: 2014-05-20 words: 1528 flesch: 37 summary: World Health Organization Guidelines for environmental infection control in health-care facilities. key: cord-275404-hv3y4x4g authors: Zumla, Alimuddin; Hui, David S title: Infection control and MERS-CoV in health-care workers date: 2014-05-20 journal: Lancet DOI: 10.1016/s0140-6736(14)60852-7 sha: doc_id: 275404 cord_uid: hv3y4x4g nan The recent exponential rise in the number of reported cases of Middle East respiratory syndrome coronavirus (MERS-CoV) is of major global concern. keywords: control; cov; health; infection; mers cache: cord-275404-hv3y4x4g.txt plain text: cord-275404-hv3y4x4g.txt item: #127 of 515 id: cord-276193-cngz535o author: Volz, A. title: Modified Vaccinia Virus Ankara: History, Value in Basic Research, and Current Perspectives for Vaccine Development date: 2016-08-01 words: 17885 flesch: 25 summary: Recombinant MVA viruses are clonally isolated in repetitive cell culture passages screening for specific selection markers. Complementation of a defect in virus production is a faster and more convenient method to obtain recombinant MVA viruses. keywords: ankara; antibodies; candidate; cells; challenge; efficacy; et al; gene; genome; host; human; immune; immunization; immunogenicity; induction; infection; influenza; mers; mice; mva; protection; protein; recombinant; responses; smallpox; vaccination; vaccine; vaccinia; vaccinia virus; vacv; vector; virus; viruses cache: cord-276193-cngz535o.txt plain text: cord-276193-cngz535o.txt item: #128 of 515 id: cord-276769-th7iou21 author: Khan, Suliman title: Coronaviruses disease 2019 (COVID-19): causative agent, mental health concerns, and potential management options date: 2020-07-25 words: 3381 flesch: 40 summary: In this paper, we discuss the transmission, health consequences, and potential management (therapeutic and preventive) options for COVID-19 disease. In this article, we briefly describe the consequences of highly infectous human corona viruses, and elaborate the transmission and health consequences (both physical and mental health) of COVID-19 disease. keywords: coronavirus; cov-2; covid-19; disease; health; sars; transmission cache: cord-276769-th7iou21.txt plain text: cord-276769-th7iou21.txt item: #129 of 515 id: cord-277337-ij0dn77h author: Cho, Hae-Wol title: Outbreak of Middle East Respiratory Syndrome in Korea? date: 2015-08-28 words: 2241 flesch: 53 summary: Also, over 30 triage hospitals for suspected cases with a temporary space for safe triage of respiratory-illness patients and isolation of suspect MERS cases have been designated nationwide. In addition to standard precautions, including hand hygiene, appropriate personal protective equipment, including gloves, gowns, and respiratory and eye protection, is used when seeing confirmed or suspected MERS cases. keywords: cases; contacts; cov; health; june; mers cache: cord-277337-ij0dn77h.txt plain text: cord-277337-ij0dn77h.txt item: #130 of 515 id: cord-277781-v9hw1cdi author: Ejima, Keisuke title: Probabilistic differential diagnosis of Middle East respiratory syndrome (MERS) using the time from immigration to illness onset among imported cases date: 2014-04-07 words: 4428 flesch: 38 summary: This indicates that the high probability of influenza would not be the case even for those developing illness in 2 days if MERS transmission was more widespread than influenza or if the cases were at high risk of MERS (e.g. with suspected exposure to camels or other MERS cases in hospital) (Assiri et al., 2013b; Reusken et al., 2013a It should also be emphasized that the viral etiological study is valuable to directly quantify q i based on empirical data, although such data may be only applicable to general travelers (and not the travelers with close contact with other MERS cases or animals (Nishiura et al., 2014) ). keywords: illness; immigration; influenza; mers; probability; time cache: cord-277781-v9hw1cdi.txt plain text: cord-277781-v9hw1cdi.txt item: #131 of 515 id: cord-277823-vijh6x1l author: TERAMICHI, Takurou title: Evaluation of serological assays available in a biosafety level 2 laboratory and their application for survey of Middle East respiratory syndrome coronavirus among livestock in Ethiopia date: 2019-11-05 words: 2260 flesch: 45 summary: In dromedary camels and cattle, 31 out of 38 and 1 out of 15, respectively, were MERS antibody positive. Goats and sheep were all MERS antibody negative (Table l) . keywords: antibody; cov; gfp; mers; neutralization; vsv cache: cord-277823-vijh6x1l.txt plain text: cord-277823-vijh6x1l.txt item: #132 of 515 id: cord-278182-75u57fw1 author: Goh, Gerard Kian-Meng title: Shell disorder analysis predicts greater resilience of the SARS-CoV-2 (COVID-19) outside the body and in body fluids date: 2020-03-31 words: 4617 flesch: 53 summary: WHO, Novel coronavirus Rigidity of outer shell predicted by protein disorder model sheds light on COVID-19(Wuhan-2019-nCoV) infectivity Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 A pneumonia outbreak associated with a new coronavirus of probable bat origin Understanding viral transmission behavior via protein intrinsic disorder prediction: Coronaviruses Viral Shapeshifters: Strange Behavoirs of Hiv and Other Viruses, Simplicity Research Institute Prediction of intrinsic disorder in MERS-CoV/ HCoV-EMC supports a high oral-fecal transmission WHO, Middle Eastern respiratory syndrome coronavirus (MERS-CoV) Identification of MERS-CoV in dromedary camels Intrinsically unstructured proteins Why are natively unfolded proteins unstructured under the physiological conditions? Intrinsically unstructured proteins: Re-assessing the protein structure-paradigm Predicting protein disorder for N-, C-, and internal regions Predicting binding regions within disordered proteins Sequence complexity of disordered protein Mining alpha-helix-forming molecular recognition features with cross species sequence alignments Coupled folding and binding with alpha-helix-forming molecular recognition elements Viral disorder or disordered viruses: do viral proteins possess unique features? The N protein is also important for our model, as it has been shown that greater disorder in the inner shell is associated with the mode of infection and virulence in other viruses keywords: cov; cov-2; pid; protein; sars; transmission; virus; viruses cache: cord-278182-75u57fw1.txt plain text: cord-278182-75u57fw1.txt item: #133 of 515 id: cord-278238-w1l8h8g8 author: Okba, Nisreen MA title: Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches date: 2017-04-13 words: 5103 flesch: 33 summary: key: cord-278238-w1l8h8g8 authors: Okba, Nisreen MA; Raj, V Stalin; Haagmans, Bart L title: Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches date: 2017-04-13 journal: Curr Opin Virol DOI: 10.1016/j.coviro.2017.03.007 sha: doc_id: 278238 cord_uid: w1l8h8g8 Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. Noteworthy to mention is Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches Okba, Raj and Haagmans 51 Ad/hDPP4-mice, mice transduced with hDPP4 in an adenoviral vector; alum, aluminum hydroxide; E, envelope protein; hDPP4, human dipeptidyl peptidase 4; i.m., intramuscular; i.n., intranasal; M, matrix protein; MERS-CoV, Middle East respiratory syndrome coronavirus; Nab, neutralizing antibodies; ND, not done; NHP, non-human primate; rNTD, recombinant N-terminal domain; RBD, receptor-binding domain; rRBD, recombinant RBD; RBD-Fc, RBD fused to the antibody crystallizable fragment of human IgG; S, spike protein; S1, S1 domain of spike protein; S367-606, amino acid residues 367-606 of the S protein; S736-761-KLH, peptide S736-761 coupled to keyhole limpet haemocyanin; s.c., subcutaneous; VLPs, Virus-like particles; a i.m.;alum/CpG ODN produced higher neutralizing antibody responses than s.c.; IFA/CpG ODN. keywords: cell; coronavirus; cov; east; infection; mers; middle; neutralizing; responses; syndrome; vaccine cache: cord-278238-w1l8h8g8.txt plain text: cord-278238-w1l8h8g8.txt item: #134 of 515 id: cord-278648-hkvurb2k author: Menachery, Vineet D. title: Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis date: 2017-11-15 words: 5209 flesch: 39 summary: A combination of structural and biochemical approaches has established a critical role for CoV NSP16 in 2=O-MTase activity (Fig. 1A) . However, absence of NSP16 activity severely attenuated dNSP16 mutant virus replication at both days 2 and 4 postinfection (Fig. 3C ). keywords: activity; attenuation; cov; dnsp16; ifn; infection; mers; mutant; replication; sars; vaccine; virus cache: cord-278648-hkvurb2k.txt plain text: cord-278648-hkvurb2k.txt item: #135 of 515 id: cord-278839-uu2wlpmp author: Alberca, Ricardo Wesley title: Pregnancy, Viral Infection, and COVID-19 date: 2020-07-07 words: 7256 flesch: 30 summary: retrospective cohort study Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis Antibodies in infants born to mothers with COVID-19 pneumonia Lack of vertical transmission of severe acute respiratory syndrome coronavirus 2, China First case of neonatal infection due to COVID 19 in Spain COVID-19 vaginal delivery-a case report Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province Coronavirus disease 2019 (COVID-19) during pregnancy: a case series COVID-19 in a 26-week preterm neonate COVID-19 Infection in First Trimester of Pregnancy Marked by a Liver Cytolysis: A Case Report Evidence of mother-to-newborn infection with COVID-19 Maternal death due to COVID-19 Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Testicular effects following in utero exposure to the antivirals acyclovir and ganciclovir in rats Pathological findings of COVID-19 associated with acute respiratory distress syndrome Interleukin-2 receptor serum concentrations in normal pregnancy and pre-eclampsia The involvement of inflammatory cytokines in the pathogenesis of recurrent miscarriage Abnormal IL-2 receptor levels in non-pregnant women with a history of recurrent miscarriage IL-7/IL-7R signaling pathway might play a role in recurrent pregnancy losses by increasing inflammatory Th17 cells and decreasing Treg cells Association of tumor necrosis factoralpha 308G/A polymorphism with recurrent miscarriages in women Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium Tumor necrosis factor-α and pregnancy complications: a prospective study Placental TNF-α signaling in illness-induced complications of pregnancy Programming of fetal insulin resistance in pregnancies with maternal obesity by ER stress and inflammation TNF-alpha is a predictor of insulin resistance in human pregnancy Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta-analysis Prenatal immune challenge affects growth, behavior, and brain dopamine in offspring In utero exposure to virus infections and the risk of developing anorexia nervosa Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness Prenatal exposure to maternal infection alters cytokine expression in the placenta, amniotic fluid, fetal brain Prenatal LPS-exposurea neurodevelopmental rat model of schizophrenia-differentially affects cognitive functions, myelination and parvalbumin expression in male and female offspring Prenatal lipopolysaccharide exposure promotes dyslipidemia in the male offspring rats Prenatal viral exposure followed by adult stress produces glucose intolerance in a mouse model Prenatal initiation of endotoxin airway exposure prevents subsequent allergeninduced sensitization and airway inflammation in mice Thrown off balance: the effect of antenatal inflammation on the developing lung and immune system Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids Hertz-Picciotto I. Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Although there is little knowledge about placental findings associated with the common coronaviruses, Ng et al. reported placental pathology in seven women with SARS infection in Hong Kong (43) . keywords: cells; coronavirus; cov-2; covid-19; disease; expression; infection; inflammatory; influenza; maternal; placental; pregnancy; response; sars; syndrome; virus; women cache: cord-278839-uu2wlpmp.txt plain text: cord-278839-uu2wlpmp.txt item: #136 of 515 id: cord-278939-z6kiee09 author: Mani, Janice S. title: Natural product-derived phytochemicals as potential agents against coronaviruses: a review date: 2020-04-30 words: 8177 flesch: 30 summary: The antiviral activity of extracts from plant species against the avian IBV viral strains have been extensively studied (Chen et al., 2014; Jackwood et al., 2010; Lelesius et al., 2019; Li et al., 2011; Nguyen et al., 2015; Yang et al., 2010; Yang et al., 2011; Yin et al., 2011) . Recent reviews have suggested that traditional Chinese medicine could be used for the prevention or treatment (Yang et al., 2020a ) of COVID-19; while still acknowledging that many studies involving clinical trials are poorly designed or controlled, and the choice of treatments is largely empirically based. keywords: activity; antiviral; compounds; coronavirus; cov; cov-2; ec50; et al; extracts; human; inhibition; mers; potential; protein; sars; studies; treatment cache: cord-278939-z6kiee09.txt plain text: cord-278939-z6kiee09.txt item: #137 of 515 id: cord-279255-v861kk0i author: Dhama, Kuldeep title: Coronavirus Disease 2019–COVID-19 date: 2020-06-24 words: 23944 flesch: 36 summary: Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein Animal models for SARS and MERS coronaviruses Recent advances in the vaccine development against Middle East respiratory syndromecoronavirus Virology: SARS virus infection of cats and ferrets A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters Animal models and vaccines for SARS-CoV infection Infection with MERS-CoV causes lethal pneumonia in the common marmoset Vaccines for the prevention against the threat of MERS-CoV Molecular basis of coronavirus virulence and vaccine development Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection Genetically engineering a susceptible mouse model for MERS-CoV-induced acute respiratory distress syndrome Prospects for a MERS-CoV spike vaccine A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Replicative capacity of MERS coronavirus in livestock cell lines Entry of human coronavirus NL63 into the cell China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response Novel coronavirus is putting the whole world on alert Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study Estimation of the transmission risk of the 2019-nCoV and its implication for public health interventions The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus The progress of 2019 novel coronavirus (2019-nCoV) event in China Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study Response to the emerging novel coronavirus outbreak Potential for global spread of a novel coronavirus from China Novel coronavirus, poor quarantine, and the risk of pandemic Novel Coronavirus outbreak in Wuhan, China, 2020: intense surveillance is vital for preventing sustained transmission in new locations Risk for transportation of 2019 novel coronavirus disease from Wuhan to other cities in China Infections without borders: a new coronavirus in Wuhan, China An interactive web-based dashboard to track COVID-19 in real time Limiting spread of COVID-19 from cruise ships-lessons to be learnt from Japan Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records A case of 2019 novel coronavirus in a pregnant woman with preterm delivery Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study A pregnant woman with COVID-19 in Central America Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). CEPI to fund three programmes to develop vaccines against the novel coronavirus, nCoV-2019 Moderna announces funding award from CEPI to accelerate development of messenger RNA (mRNA) vaccine against novel coronavirus Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms Treatment with interferon-␣2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics Potential antiviral therapeutics for 2019 novel coronavirus A novel coronavirus outbreak of global health concern Coronavirusesdrug discovery and therapeutic options Treatment with lopinavir/ritonavir or interferon-␤1b improves outcome of MERS-CoV infection in a nonhuman primate model of common Marmoset Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-␤1b (MIRACLE trial): study protocol for a randomized controlled trial Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein Characterization of novel monoclonal antibodies against MERScoronavirus spike protein Crossneutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses New coronavirus threat galvanizes scientists Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitors Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Potential interventions for novel coronavirus in China: a systemic review Human transbodies that interfere with the functions of Ebola virus VP35 protein in genome replication and transcription and innate immune antagonism Inhibitors of RAS might be a good choice for the therapy of COVID-19 pneumonia Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture keywords: acute; animal; bat; cases; cell; china; control; coronavirus; cov-2; covid-19; covs; disease; drugs; health; host; human; infection; mers; ncov; novel; novel coronavirus; outbreak; patients; pneumonia; potential; protein; respiratory; risk; sars; sars coronavirus; spread; studies; study; syndrome; transmission; treatment; vaccine; viruses; wuhan cache: cord-279255-v861kk0i.txt plain text: cord-279255-v861kk0i.txt item: #138 of 515 id: cord-279503-w4tn03w0 author: Kim, Hanbi title: Development of Label-Free Colorimetric Assay for MERS-CoV Using Gold Nanoparticles date: 2019-05-07 words: 3547 flesch: 42 summary: Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles Gold nanoparticles for naked-eye DNA detection: smart designs for sensitive assays Label-free colorimetric detection of specific sequences in genomic DNA amplified by the polymerase chain reaction Disulfide-induced self-assembled targets: A novel strategy for the label free colorimetric detection of DNAs/RNAs via unmodified gold nanoparticles Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers Laboratory testing for Middle East Respiratory Syndrome Coronavirus Interim guidance Thermal stability of DNA functionalized gold nanoparticles Colorimetric detection originating from gold nanoparticles (AuNPs) have been intensively studied because of their particular optical properties, i.e., localized surface plasmon resonance (LSPR), which represent a color with maximal absorbance wavelength. keywords: aunps; disulfide; dna; figure; gold; mers; self; target cache: cord-279503-w4tn03w0.txt plain text: cord-279503-w4tn03w0.txt item: #139 of 515 id: cord-279557-hk77e3pp author: Drosten, Christian title: Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection date: 2013-06-17 words: 4220 flesch: 51 summary: The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. We report data for a patient who was admitted to the Klinikum Schwabing (Munich, Germany) for severe acute respiratory infection. keywords: coronavirus; cov; data; day; infection; mers; patient; respiratory; samples; virus cache: cord-279557-hk77e3pp.txt plain text: cord-279557-hk77e3pp.txt item: #140 of 515 id: cord-279733-c0w9bw5u author: Lui, Pak-Yin title: Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3 date: 2016-04-20 words: 5260 flesch: 37 summary: IRF3 phosphorylation was also suppressed with the expression of MERS M protein in a similar experimental setup ( Figure 4D ; lane 3 compared with lane 2). M proteins from MERS-CoV and SARS-CoV have three highly similar conserved N-terminal transmembrane domains and a C-terminal region. keywords: activation; coronavirus; cov; cov m; ifn; irf3; m protein; mers; protein; respiratory; traf3 cache: cord-279733-c0w9bw5u.txt plain text: cord-279733-c0w9bw5u.txt item: #141 of 515 id: cord-279976-juz9jnfk author: Xie, Mingxuan title: Insight into 2019 novel coronavirus — an updated intrim review and lessons from SARS-CoV and MERS-CoV date: 2020-04-01 words: 3921 flesch: 42 summary: JAMA 2020a Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2) using whole genomic data Summary of probable SARS cases with onset of illness from 1 WHO . MedRxiv(preprint) 2020 MERS transmission and risk factors: a systematic review Lung pathology and pathogenesis of severe acute respiratory syndrome: a report of six full autopsies A report on the general observation of a 2019 novel coronavirus autopsy Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Evaluation of Convalescent Plasma for Ebola Virus Disease in Guinea Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. keywords: 2019; clinical; coronavirus; covid-19; mers; ncov; novel; patients; sars cache: cord-279976-juz9jnfk.txt plain text: cord-279976-juz9jnfk.txt item: #142 of 515 id: cord-279979-3ecnbqom author: Anthony, S. J. title: Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus date: 2017-04-04 words: 5355 flesch: 39 summary: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Evidence for camel-to-human transmission of MERS coronavirus Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Uganda MERS-Like Virus in Bats ® MERS coronaviruses in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Antibodies against MERS coronavirus in dromedary camels MERS coronavirus neutralizing antibodies in camels, eastern Africa Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study Molecular diversity of coronaviruses in bats Close relative of human Middle East respiratory syndrome coronavirus in bat Rooting the phylogenetic tree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Coronavirus spike proteins in viral entry and pathogenesis Bat-to-human: KEYWORDS bat, MERS coronavirus, spike, Uganda, zoonoses I n 2012, Middle East respiratory syndrome (MERS) emerged in Saudi Arabia. keywords: bat; bats; coronavirus; cov; dpp4; human; mers; pdf-2180; predict; protein; receptor; recombination; sequence; spike; syndrome cache: cord-279979-3ecnbqom.txt plain text: cord-279979-3ecnbqom.txt item: #143 of 515 id: cord-280029-g1k3zlax author: Gabutti, Giovanni title: Coronavirus: Update Related to the Current Outbreak of COVID-19 date: 2020-04-08 words: 5020 flesch: 50 summary: As of March 9, 2020, considering that new cases of COVID-19 registered in Italy had started to increase considerably and national restrictive measures had not yet been put in place, the Council of Ministers issued a decree law with measures to prohibit access to and exit from the country as well as suspension of all the activities that were not strictly necessary [46, 47] . Patients with COVID-19 should receive supportive care to help relieve symptoms, and, for severe cases, treatment should include care to support vital organ functions keywords: cases; china; coronavirus; cov-2; covid-19; health; infection; mers; patients; sars; transmission cache: cord-280029-g1k3zlax.txt plain text: cord-280029-g1k3zlax.txt item: #144 of 515 id: cord-280350-ay4cnzn5 author: Chan, Jasper F.W. title: Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus date: 2013-10-03 words: 5166 flesch: 34 summary: 73 Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic The emerging novel Middle East respiratory syndrome coronavirus: the knowns and unknowns Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV); announcement of the coronavirus study group Global alert and response: Middle East respiratory syndrome coronavirus (MERS-CoV) e update e as of 4 October Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features Genetic relatedness of the novel human lineage C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 Genetic characterization of Betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East Respiratory Syndrome Coronavirus Interspecies transmission and emergence of novel viruses: lessons from bats and birds Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Coronaviruses in bats from Mexico Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications on disease pathogenesis and clinical manifestation Human coronavirus EMC does not require the SARScoronavirus receptor and maintains broad replicative capability in mammalian cell lines Middle East respiratory syndrome coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Update: severe respiratory illness associated with middle East respiratory syndrome coronavirus (MERS-CoV) e Worldwide Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Family cluster of middle East respiratory syndrome coronavirus infections Hospital outbreak of middle East respiratory syndrome coronavirus A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case First cases of middle East respiratory syndrome coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Identification of influenza A nucleoprotein as an antiviral target Two years after pandemic influenza A/2009/H1N1: what have we learned? Avian influenza A H5N1 virus: a continuous threat to humans Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome The emergence of influenza A (H7N9) sixteen years after influenza A(H5N1) in humans: a tale of two cities Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Treatment of SARS with human interferons Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells Characterization of SARS-CoV main protease and identification of biologically active small molecule inhibitors using a continuous fluorescence-based assay Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin Mycophenolate mofetil: an update Identification of active antiviral compounds against a New York isolate of West Nile virus Mycophenolic acid inhibits replication of Japanese encephalitis virus The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells Antiviral or proviral action of mycophenolic acid in hepatitis B infection? keywords: acid; coronavirus; cov; east; human; interferon; mers; middle; ribavirin; sars; syndrome cache: cord-280350-ay4cnzn5.txt plain text: cord-280350-ay4cnzn5.txt item: #145 of 515 id: cord-280624-7v8xuicg author: Ba Abduallah, Mohamed M. title: Comparative analysis of the genome structure and organization of the Middle East respiratory syndrome coronavirus (MERS‐CoV) 2012 to 2019 revealing evidence for virus strain barcoding, zoonotic transmission, and selection pressure date: 2020-08-17 words: 2585 flesch: 57 summary: The phylogenetic tree of the 57 MERS-CoV of S gene sequences is presented in Figure 2C . Comparative genome sequence analysis of the MERS-CoV of both dromedary camels and human origins revealed significant evidence for potential barcoding of the African clades based on the S gene sequences. keywords: cov; gene; genome; mers; sequences; table cache: cord-280624-7v8xuicg.txt plain text: cord-280624-7v8xuicg.txt item: #146 of 515 id: cord-280941-ds6x0yym author: Kim, Young-Seok title: Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles date: 2018-05-17 words: 9430 flesch: 44 summary: Six-week-old female BALB/c mice were immunized with 20 µg/ mouse of the RBD-FR, RBD-[SSG]-FR, or RBD protein generated as described above, or with commercially available MERS-CoV RBD protein (MERS-RBD-005P; eEnzyme) as antigen in BSL-2 facility in YLARC. [RBD-[SSG]-FR, RBD-FR, RBD, and FR (negative control)]-immunized mouse serum inhibited binding of RBD protein to hDPP4 receptor (45, 46) . keywords: antigens; assembly; binding; cov; figure; folding; hrid; mers; nps; protein; rbd; rbd-[ssg]-fr; receptor; rna; solubility cache: cord-280941-ds6x0yym.txt plain text: cord-280941-ds6x0yym.txt item: #147 of 515 id: cord-281364-syg0wo77 author: Caì, Yíngyún title: CD26/DPP4 Cell-Surface Expression in Bat Cells Correlates with Bat Cell Susceptibility to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Evolution of Persistent Infection date: 2014-11-19 words: 3835 flesch: 44 summary: Our study confirms the role of CD26/DPP4 as receptor for two divergent MERS-CoV isolates and correlates its presence or absence on the surface of bat cells directly with bat cell susceptibility or resistance to productive MERS-CoV infection (Figures 2 and 3 ). Bat cells were washed with phosphate-buffered saline (PBS) and then dissociated with cell dissociation buffer (Life Technologies). keywords: bat; cd26; cells; coronavirus; cov; dpp4; human; infection; lines; mers; syndrome cache: cord-281364-syg0wo77.txt plain text: cord-281364-syg0wo77.txt item: #148 of 515 id: cord-281529-2rec51xg author: Haagmans, Bart L title: Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation date: 2013-12-17 words: 4037 flesch: 51 summary: Global Alert and Response (GAR): novel coronavirus infection-update Ecology, evolution and classifi cation of bat coronaviruses in the aftermath of SARS Close relative of human Middle East respiratory syndrome coronavirus in bat Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Genetic characterization of betacoronavirus lineage C viruses in bats revealed marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications on the origin of the novel Middle East Respiratory Syndrome Coronavirus Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Transmission scenarios for Middle East respiratory syndrome coronavirus (MERS-CoV) and how to tell them apart Recovery from severe novel coronavirus infection Family cluster of Middle East respiratory syndrome coronavirus infections Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Alert and Response (GAR): novel coronavirus infection-update Alert and Response (GAR): novel coronavirus infection-update Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confi rmation of novel human coronavirus (hCoV-EMC) infections SeaView version 4: a multiplatform graphical user interface for sequence alignment and phylogenetic tree building Specifi c serology for emerging human coronaviruses by protein microarray Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronavirus: data gaps for laboratory preparedness We thank WHO and the Food and Agriculture Organization of the United Nations for their generous help in organisation of the study, Theo Bestebroer for providing Middle East respiratory syndrome coronavirus specifi c primer sets, Berend Jan Bosch for providing antigens for the microarray, and Jeroen Cremer for technical support. Viral sequences from the two human cases were isolated (with the same techniques as for camel cases) in the Reference Department, Public Health England, London, UK. keywords: camels; cases; coronavirus; cov; data; farm; human; infection; mers; pcr; samples cache: cord-281529-2rec51xg.txt plain text: cord-281529-2rec51xg.txt item: #149 of 515 id: cord-281802-9k6klcno author: German, Matthew title: Acute Respiratory Infections in Travelers Returning from MERS-CoV–Affected Areas date: 2015-09-17 words: 1387 flesch: 37 summary: Although the risk for MERS-CoV importation is low, respiratory virus infections acquired abroad or locally after returning to Canada might be relatively high and consistent, occurring in 87 (49.2%) of 177 PUIs during the study period. Statistical yearbook Tools for preparedness: triage, screening and patient management for Middle East respiratory syndrome coronavirus (MERS-CoV) infections in acute care settings Respiratory viruses and bacteria among pilgrims during the Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Analytical and clinical validation of novel real-time reverse transcriptase-polymerase chain reaction assays for the clinical detection of swine-origin H1N1 influenza viruses Dual detection of Legionella pneumophila and Legionella species by real-time PCR targeting the 23S-5S rRNA gene spacer region Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia Table 427-0006. keywords: cov; influenza; mers; puis; respiratory cache: cord-281802-9k6klcno.txt plain text: cord-281802-9k6klcno.txt item: #150 of 515 id: cord-282279-zmfcfbo8 author: Lee, Sang Min title: Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodialysis patients date: 2018-11-30 words: 3320 flesch: 45 summary: The present study aimed to understand the immediate stress and psychological impact experienced by healthcare workers who treated patients MERS during the outbreak period, and hospital quarantined patients, especially undergoing hemodialysis, who had been exposed to MERS. The proportion of staff involved in caring for MERS patients was 18.89%; 27.1% of them participated in the survey. keywords: hospital; ies; mers; outbreak; patients; survey cache: cord-282279-zmfcfbo8.txt plain text: cord-282279-zmfcfbo8.txt item: #151 of 515 id: cord-282293-pdhjl508 author: Park, Wan Beom title: Isolation of Middle East Respiratory Syndrome Coronavirus from a Patient of the 2015 Korean Outbreak date: 2016-01-14 words: 1579 flesch: 49 summary: key: cord-282293-pdhjl508 authors: Park, Wan Beom; Kwon, Nak-Jung; Choe, Pyoeng Gyun; Choi, Su-Jin; Oh, Hong Sang; Lee, Sang Min; Chong, Hyonyong; Kim, Jong-Il; Song, Kyoung-Ho; Bang, Ji Hwan; Kim, Eu Suk; Kim, Hong-Bin; Park, Sang Won; Kim, Nam Joong; Oh, Myoung-don title: Isolation of Middle East Respiratory Syndrome Coronavirus from a Patient of the 2015 Korean Outbreak date: 2016-01-14 journal: J Korean Med Sci DOI: 10.3346/jkms.2016.31.2.315 sha: doc_id: 282293 cord_uid: pdhjl508 During the 2015 outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Korea, 186 persons were infected, resulting in 38 fatalities. Middle East respiratory syndrome corona Saudi Arabia: disease outbreak news Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study What needs to be done to control the spread of Middle East respiratory syndrome coronavirus? Middle East respiratory syndrome coronavirus superspreading Event Involving 81 Persons, Korea Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus Microevolution of outbreak-associated Middle East respiratory syndrome coronavirus Variations in spike glycoprotein gene of MERS-CoV Origin and possible genetic recombination of the Middle East respiratory syndrome coronavirus from the first imported case in China: phylogenetics and coalescence analysis Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees MEGA6: molecular evolutionary genetics analysis version 6.0 keywords: coronavirus; cov; east; mers; middle; syndrome cache: cord-282293-pdhjl508.txt plain text: cord-282293-pdhjl508.txt item: #152 of 515 id: cord-282554-hlcgutzf author: Yoo, Jin-Hong title: The Fight against the 2019-nCoV Outbreak: an Arduous March Has Just Begun date: 2020-01-30 words: 602 flesch: 59 summary: WHO issues best practices for naming new human infectious diseases Surveillance case definitions for human infection with novel coronavirus (nCoV) A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence Origin and evolution of pathogenic coronaviruses Tracking coronavirus: map, data and timeline Clinical and epidemiologic characteristics of spreaders of middle east respiratory syndrome coronavirus during the 2015 outbreak in Korea Most coronaviruses cause only mild upper respiratory infections, but sometimes they cause fatal respiratory disease and outbreaks, as experienced in cases of SARS-CoV or MERS-CoV. keywords: cov; outbreak cache: cord-282554-hlcgutzf.txt plain text: cord-282554-hlcgutzf.txt item: #153 of 515 id: cord-282560-tofppr3b author: Henderson, Jack A. title: Assessment of proton-coupled conformational dynamics of SARS and MERS coronavirus papain-like proteases: Implication for designing broad-spectrum antiviral inhibitors date: 2020-09-21 words: 6257 flesch: 47 summary: Consistent with our previous work, 36 we found that the protonation states of His residues converge rapidly within 10 ns per replica, and those of Cys converge more slowly due to the formation of hydrogen bonds that are not present in the crystal structure (see later discussion). 4 Crystal structures show that BL2 is open in the unbound SARS-CoV PLpro and it closes by about 1.5 Å-2 Å in the bound form, which allows hydrogen bonds to form between Tyr269/Gln270 and the inhibitor. keywords: bl2; cov; cov plpro; cov-2; fig; hydrogen; mers; pka; plpro; sars; simulations cache: cord-282560-tofppr3b.txt plain text: cord-282560-tofppr3b.txt item: #154 of 515 id: cord-283586-o8m6xdra author: Spanakis, Nikolaos title: Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen date: 2014-12-31 words: 3280 flesch: 37 summary: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Clinical Decision Making Tool for Treatment of MERS-CoV v A case of imported Middle East respiratory syndrome coronavirus infection and public health response Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Ribavirin and interferon (IFN)-␣-2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus (MERS-CoV): a preliminary report of two cases Treatment with interferon-␣2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Schering Corp Product information. Switzerland: WHO Long-term SARS coronavirus excretion from patient cohort Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential Interferon-␤ and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Inhibition of novel ␤ coronavirus replication by a combination of interferon-␣2b and ribavirin In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) coronavirus infection Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Hospital outbreak of Middle East keywords: coronavirus; cov; east; mers; middle; patient; syndrome; testing cache: cord-283586-o8m6xdra.txt plain text: cord-283586-o8m6xdra.txt item: #155 of 515 id: cord-283709-y59h5bw8 author: Chan, Renee W Y title: Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study date: 2014-08-28 words: 4865 flesch: 47 summary: The similarity of virus tropism and replication competence of human and dromedary MERS-CoV from the Arabian peninsula, and genetically diverse dromedary viruses from Egypt, in ex-vivo cultures of the human respiratory tract suggests that dromedary viruses from Saudi Arabia and Egypt are probably infectious to human beings. Full genome sequences of dromedary viruses suggest that these viruses are similar to viruses in humans. keywords: cells; cov; cultures; dromedary; human; infection; mers; virus; viruses cache: cord-283709-y59h5bw8.txt plain text: cord-283709-y59h5bw8.txt item: #156 of 515 id: cord-283966-eln8ljjj author: Meyer, Benjamin title: Antibodies against MERS Coronavirus in Dromedary Camels, United Arab Emirates, 2003 and 2013 date: 2014-04-17 words: 4028 flesch: 42 summary: To characterize reactivity of camel serum samples with MERS-CoV in different assay formats, we chose 11 camel serum samples with weak and strong reactivity predetermined by using a simple IFA. Typical patterns of reactivity observed for camel serum samples are shown in the Figure, panel A. A previously published microarray-based assay that used the receptor-binding S1 spike subunit of MERS-CoV (MERS-S1), human CoV-OC43 (OC43-S1), and SARS-CoV (SARS-S1) was also evaluated. keywords: bats; camels; coronavirus; cov; human; mers; neutralization; samples; serum; titers cache: cord-283966-eln8ljjj.txt plain text: cord-283966-eln8ljjj.txt item: #157 of 515 id: cord-284057-pdjz4z8z author: Choi, Jeong Sil title: Crisis prevention and management by infection control nurses during the Middle East respiratory coronavirus outbreak in Korea date: 2016-04-01 words: 1656 flesch: 44 summary: During these visits, they provided instruction on infection control guidelines, such as PPE use and environment decontamination, and offered advice on the practice of infection control. In another important role, the nursing professors informed the government of difficulties and problems related to MERS infection control in hospitals, so that these problems would be resolved and there would be support for the necessary resources. keywords: control; cov; infection; mers cache: cord-284057-pdjz4z8z.txt plain text: cord-284057-pdjz4z8z.txt item: #158 of 515 id: cord-284234-9cd2v6bt author: Sebastian, S title: Safety of drugs during previous and current coronavirus pandemics: Lessons for IBD date: 2020-06-10 words: 4490 flesch: 29 summary: One of the key challenges needing addressing is the quantification of the risks of immunosuppressive and biologic therapies in IBD patients during the pandemic. Although clinical, immunological and pharmacological data from the experience with the previous coronavirus outbreaks cannot be automatically translated to predict the safety of IBD therapies during COVID-19 pandemic, the signals so far from these outbreaks on IBD patients who are on immunomodulators and biologics are reassuring to patients and clinicians alike. keywords: bowel; coronavirus; covid-19; disease; ibd; infection; mers; patients; risk; sars cache: cord-284234-9cd2v6bt.txt plain text: cord-284234-9cd2v6bt.txt item: #159 of 515 id: cord-284286-qfl6hehj author: Woo, Patrick C. Y. title: Isolation and Characterization of Dromedary Camel Coronavirus UAE-HKU23 from Dromedaries of the Middle East: Minimal Serological Cross-Reactivity between MERS Coronavirus and Dromedary Camel Coronavirus UAE-HKU23 date: 2016-05-07 words: 6120 flesch: 47 summary: The highest dilutions of the serum, obtained from the mouse immunized with the MERS-CoV N protein, which generated immunoreactive bands in the Western blot assay, were 1:512,000 and 1:8000, respectively, when the MERS-CoV N protein and DcCoV UAE-HKU23 N protein were used as the antigens, respectively ( Figure 4 ). The highest dilutions of the serum, obtained from the mouse immunized with the MERS-CoV N protein, which generated immunoreactive bands in the Western blot assay, were 1:512,000 and 1:8000, respectively, when the MERS-CoV N protein and DcCoV UAE-HKU23 N protein were used as the antigens, respectively ( Figure 4 ). keywords: antibody; betacoronavirus; coronavirus; covs; dccov uae; figure; hku23; mers; samples; serum; subgenomic cache: cord-284286-qfl6hehj.txt plain text: cord-284286-qfl6hehj.txt item: #160 of 515 id: cord-284289-8emvca57 author: Schuster, Jennifer E. title: Emerging Respiratory Viruses in Children date: 2018-03-31 words: 3392 flesch: 37 summary: Mandell, Douglas, and Bennett's principles and practice of infectious diseases Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans Sudden increase in human infection with avian influenza A(H7N9) virus in China Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation Differences in the epidemiology of childhood infections with avian influenza A H7N9 and H5N1 viruses A human-infecting H10N8 influenza virus retains a strong preference for avian-type receptors Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia Highly pathogenic asian avian influenza A (H5N1) in people Risk parameters of fulminant acute respiratory distress syndrome and avian influenza (H5N1) infection in Vietnamese children Clinical factors associated with severity in hospitalized children infected with avian influenza (H5N1) Epidemiological, clinical and viral characteristics of fatal cases of human avian influenza A (H7N9) virus in Zhejiang Province Human infection with a novel avian-origin influenza A (H7N9) virus Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study No evidence H10N8 avian influenza virus infections among poultry workers in Guangdong province before 2013 Development and validation of a one-step real-time PCR assay for simultaneous detection of subtype H5, H7, and H9 avian influenza viruses Antiviral dosage. MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during Emerging Respiratory Viruses in Children Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children Patient characteristics and severity of human rhinovirus infections in children Community-wide, contemporaneous circulation of a broad spectrum of human rhinoviruses in healthy Australian preschool-aged children during a 12-month period Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong children Role of rhinovirus C respiratory infections in sick and healthy children in Spain Novel human rhinoviruses and exacerbation of asthma in children Human rhinovirus C associated with wheezing in hospitalised children in the Middle East Human rhinovirus C: age, season, and lower respiratory illness over the past 3 decades Molecular epidemiology of human rhinovirus infections in the pediatric emergency department Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions High detection frequency and viral loads of human rhinovirus species A to C in fecal samples; diagnostic and clinical implications Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C Developing a vaccine for human rhinoviruses guideline for isolation precautions: preventing transmission of infectious agents in health care settings keywords: avian; children; human; influenza; novel; viruses cache: cord-284289-8emvca57.txt plain text: cord-284289-8emvca57.txt item: #161 of 515 id: cord-284374-sqxlnk9e author: Park, Jiyeon title: Infection Prevention Measures for Surgical Procedures during a Middle East Respiratory Syndrome Outbreak in a Tertiary Care Hospital in South Korea date: 2020-01-15 words: 4256 flesch: 39 summary: Moreover, there may be very few hospitals that are prepared to provide perioperative care for MERS patients. Almost all hospitals generally have positive-pressure operating rooms and they may experience an outbreak without facilities that are prepared for perioperative management of MERS patients, as our hospital did in 2015. keywords: hcws; infection; mers; middle; operating; outbreak; patients; ppe; pressure; room cache: cord-284374-sqxlnk9e.txt plain text: cord-284374-sqxlnk9e.txt item: #162 of 515 id: cord-284581-fl2nt4ak author: Kleine-Weber, Hannah title: Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells date: 2019-07-19 words: 3207 flesch: 42 summary: In order to study host cell entry driven by S proteins from the C1 subclade, we employed PCR-based mutagenesis to generate expression constructs for the S proteins of MERS-CoV from Morocco (camel/Morocco/CIRAD-HKU213/2015, MO), Nigeria (camel/Nigeria/NV1657/ 2016, NI) and Burkina Faso (camel/Burkina Faso/CIRAD-HKU785/ 2015, BF), using a published expression construct for MERS-CoV EMC S protein as template (Kleine-Weber et al., 2018 . S proteins of North/West-and West-African MERS-CoV isolates from dromedary camels efficiently bind to DPP4. keywords: cells; coronavirus; cov; dpp4; et al; mers; proteins cache: cord-284581-fl2nt4ak.txt plain text: cord-284581-fl2nt4ak.txt item: #163 of 515 id: cord-284845-on97zu6w author: Falcinelli, Shane D. title: Integration of Global Analyses of Host Molecular Responses with Clinical Data To Evaluate Pathogenesis and Advance Therapies for Emerging and Re-emerging Viral Infections date: 2016-07-29 words: 8479 flesch: 29 summary: The pathway ORA of the kinome data demonstrated that Congo Basin MPXV infection resulted in strong down-regulation of a large proportion of host cell responses, most notably apoptosis, in comparison to West African MPXV. Global suppression of the host antiviral response by Ebolaand Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses Ebola virus modulates transforming growth factor beta signaling and cellular markers of mesenchyme-like transition in hepatocytes Human monkeypox Status of human monkeypox: clinical disease, epidemiology and research A tale of two clades: monkeypox viruses Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates Clinical manifestations of human monkeypox influenced by route of infection Cytokine modulation correlates with severity of monkeypox disease in humans Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox Genomic variability of monkeypox virus among humans Comparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals viral-specific regulation of immune responses Stunned silence: gene expression programs in human cells infected with monkeypox or vaccinia virus Systems kinomics demonstrates Congo Basin monkeypox virus infection selectively modulates host cell signaling responses as compared to West African monkeypox virus Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication Dynamic phosphorylation of VP30 is essential for Ebola virus life cycle Structural phosphoprotein M2-1 of the human respiratory syncytial virus is an RNA binding protein Phosphorylation status of the phosphoprotein P of rinderpest virus modulates transcription and replication of the genome A comparison of the chicken and turkey proteomes and phosphoproteomes in the development of poultry-specific immuno-metabolism kinome peptide arrays Characterization of the host response to pichinde virus infection in the Syrian golden hamster by speciesspecific kinome analysis Computational analysis of the predicted evolutionary conservation of human phosphorylation sites keywords: analysis; cell; cov; disease; ebov; host; human; infected; infection; kinase; kinome; mers; mpxv; patients; responses; signaling; viral; virus cache: cord-284845-on97zu6w.txt plain text: cord-284845-on97zu6w.txt item: #164 of 515 id: cord-285039-9piio754 author: Zhou, Haixia title: Crystallization and Structural Determination of the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein date: 2019-09-14 words: 1941 flesch: 56 summary: The purification method is the same as that of RBD protein. For details on the principles and methodology of protein crystallography, please refer to the range of other excellent textbooks. keywords: cov; mers; protein; rbd cache: cord-285039-9piio754.txt plain text: cord-285039-9piio754.txt item: #165 of 515 id: cord-285900-3rr0j5tk author: Du, Lanying title: Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines date: 2016-11-22 words: 6483 flesch: 41 summary: Whether an outcome of viral evolution or vaccine design, these immunodominant non-neutralizing epitopes on viral RBDs can outcompete other epitopes in triggering host immune responses, so that the resulting immune responses target these non-neutralizing epitopes while neglecting neutralizing epitopes on viral RBDs (refs 7-10) . Thus, masking an epitope on the RBD core structure with a high negative NII refocuses the host immune response on neutralizing epitopes on the RBM, leading to enhanced neutralizing immunogenicity of the RBD vaccine. keywords: binding; cov; design; epitopes; fig; glycan; immunogenicity; mers; nii; rbd; rbds; vaccine cache: cord-285900-3rr0j5tk.txt plain text: cord-285900-3rr0j5tk.txt item: #166 of 515 id: cord-286072-kgpvdb42 author: Sa Ribero, Margarida title: Interplay between SARS-CoV-2 and the type I interferon response date: 2020-07-29 words: 7034 flesch: 36 summary: A virus-cell protein interaction map performed with 26 of the 29 SARS-CoV-2 proteins expressed in human embryonic kidney (HEK)293T identified several innate immune signaling proteins as partners of viral proteins cells (Fig 1) Science. 2020: eabc3545 Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction Epstein-Barr virusencoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement Mozobil(R) (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration TRIM8 is required for virusinduced IFN response in human plasmacytoid dendritic cells Development of Pin1 inhibitors and their potential as therapeutic agents Disease-promoting effects of type I interferons in viral, bacterial, and coinfections A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals We thank Nathalie J. Arhel for helpful discussion. keywords: cells; coronavirus; cov-2; covid-19; human; ifn; infection; interferon; isgs; patients; replication; respiratory; response; sars; type cache: cord-286072-kgpvdb42.txt plain text: cord-286072-kgpvdb42.txt item: #167 of 515 id: cord-286298-pn9nwl64 author: Helmy, Yosra A. title: The COVID-19 Pandemic: A Comprehensive Review of Taxonomy, Genetics, Epidemiology, Diagnosis, Treatment, and Control date: 2020-04-24 words: 9320 flesch: 44 summary: The other third of SARS CoV-2 includes four genes (in green) that encode four structural proteins (S, M, E, N), and six accessory genes (in blue) that encode six accessory proteins (orf3a, orf6, orf7a, orf7b, orf8, and orf10). While the SARS-CoV-2 S2 subunit was conserved, the S1 subunit shares an overall 70% identity with those of bat and human SARS-CoV. keywords: 2019; analysis; bat; cases; china; coronavirus; cov-2; covid-19; disease; genome; human; infection; mers; novel; patients; protein; rna; sars; transmission; viruses cache: cord-286298-pn9nwl64.txt plain text: cord-286298-pn9nwl64.txt item: #168 of 515 id: cord-286472-pqtem19t author: McFee, R.B. title: MIDDLE EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS date: 2020-07-28 words: 5367 flesch: 40 summary: Of note, co-infection with other respiratory viruses and a few cases of co-infection with communityacquired bacteria at admission has been reported in MERS CoV patients. Patients recently returning from the Middle East, presenting with significant respiratory illness, with CT findings of peribronchial region abnormalities, organizing pneumonia, should be considered for MERS CoV infection, and if possible, queried about international travel and occupational exposures. keywords: cases; coronavirus; cov; east; infection; mers; middle; patients; sars; serum; specimen; syndrome; testing; treatment cache: cord-286472-pqtem19t.txt plain text: cord-286472-pqtem19t.txt item: #169 of 515 id: cord-286631-3fmg3scx author: Pormohammad, Ali title: Comparison of confirmed COVID‐19 with SARS and MERS cases ‐ Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta‐analysis date: 2020-06-05 words: 3676 flesch: 28 summary: Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Association between severity of MERS-CoV infection and incubation period Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Identified transmission dynamics of Middle East respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia Preliminary epidemiologic assessment of MERS-CoV outbreak in South Korea Clinical and epidemiologic characteristics of spreaders of Middle East respiratory syndrome coronavirus during the 2015 outbreak in Korea Transmission of MERScoronavirus in household contacts Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Hospital outbreaks of middle east respiratory syndrome Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Outbreaks of Middle East respiratory syndrome in two hospitals initiated by a single patient in Daejeon Covid-19: WHO declares pandemic because of alarming levels of spread, severity, and inaction Comparison of severe and non-severe COVID-19 pneumonia: review and meta-analysis. A novel coronavirus outbreak of global health concern Three Emerging Coronaviruses in Two Decades: the Story of SARS, MERS, and Now COVID-19 Severe acute respiratory syndrome (SARS): epidemiology and clinical features Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission A novel coronavirus from patients with pneumonia in China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-toperson transmission: a study of a family cluster Responding to Covid-19-A once-in-a-century pandemic? Rational use of personal protective equipment for coronavirus disease 2019 (COVID-19) Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement The development of a critical appraisal tool for use in systematic reviews: addressing questions of prevalence Statistical aspects of the analysis of data from retrospective studies Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Early epidemiological analysis of the 2019-nCoV outbreak based on a crowdsourced data Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-Infected pneumonia in Wuhan Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 2019 novel coronavirus infection in China Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia. keywords: acute; clinical; coronavirus; covid-19; east; mers; middle; outbreak; patients; sars; syndrome cache: cord-286631-3fmg3scx.txt plain text: cord-286631-3fmg3scx.txt item: #170 of 515 id: cord-286683-mettlmhz author: Ortiz-Prado, Esteban title: Clinical, molecular and epidemiological characterization of the SARS-CoV2 virus and the Coronavirus disease 2019 (COVID-19), a comprehensive literature review date: 2020-05-30 words: 13331 flesch: 37 summary: medRxiv Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Temporal dynamics in viral shedding and transmissibility of COVID-19 Presumed asymptomatic carrier transmission of COVID-19 Potential presymptomatic transmission of SARS-CoV-2 Interferon-stimulated genes and their antiviral effector functions RIG-I in RNA virus recognition RNA recognition and signal transduction by RIG-I-like receptors Recognition of viral single-stranded RNA by Toll-like receptors Mechanisms of innate immune evasion in re-emerging RNA viruses Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections Immunopathogenesis of coronavirus infections: implications for SARS Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology Middle East respiratory syndrome Interaction of SARS and MERS coronaviruses with the antiviral interferon response SARS and MERS: recent insights into emerging coronaviruses Dysregulation of immune response in patients with COVID-19 in Wuhan Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of the macrophage activation syndrome: Re-analysis of a prior Phase III trial A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19) Effects of chloroquine on viral infections: an old drug against today's diseases Chloroquine is a potent inhibitor of SARS coronavirus infection and spread In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Baricitinib as potential treatment for 2019-nCoV acute respiratory disease COVID-19: consider cytokine storm syndromes and immunosuppression. Three recent examples of these viral jumps include SARS CoV, MERS-CoV and SARS CoV-2 virus. keywords: acute; cases; cells; china; clinical; coronavirus; cov-2; covid-19; disease; health; human; infection; influenza; mers; ncov; novel; novel coronavirus; patients; pneumonia; protein; r n; responses; sars; study; syndrome; treatment; use; vaccine; wuhan cache: cord-286683-mettlmhz.txt plain text: cord-286683-mettlmhz.txt item: #171 of 515 id: cord-286703-ipoj13va author: de Wilde, Adriaan H. title: Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model date: 2017-01-15 words: 3357 flesch: 38 summary: The outcome of the clinical use of interferons was variable, with some reports questioning the long-term survival benefits (Al-Tawfiq et al., 2014; Omrani et al., 2014; Shalhoub et al., 2015) , whereas others suggested that further investigation is warranted (Khalid et al., 2016) , possibly in combination with the use of lopinavir/ritonavir (Kim et al., 2015) . Among these, alisporivir (ALV) showed increased sustained viral response during treatment of chronic hepatitis C virus (HCV) infection in phase III clinical trials, when treatment with ribavirin and pegylated interferon was combined with ALV (Buti et al., 2015; Flisiak et al., 2012; Pawlotsky et al., 2015; Zeuzem et al., 2015) . keywords: alv; cells; coronavirus; cov; et al; mers; replication cache: cord-286703-ipoj13va.txt plain text: cord-286703-ipoj13va.txt item: #172 of 515 id: cord-286741-h3oix9zc author: Park, Mee Sook title: Animal models for the risk assessment of viral pandemic potential date: 2020-04-22 words: 9626 flesch: 42 summary: A viruses Rescue of influenza A virus from recombinant DNA A DNA transfection system for generation of influenza A virus from eight plasmids African green monkey kidney (Vero) cells provide an alternative host cell system for influenza A and B viruses High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state Receptor binding specificity of recent human H3N2 influenza viruses Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses Pathogenesis of influenza virus infections: the good, the bad and the ugly Molecular pathology of emerging coronavirus infections Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses Replication and pathogenic potential of influenza A virus subtypes H3, H7, and H15 from free-range ducks in Bangladesh in mammals Virulence determinants of pandemic A(H1N1)2009 influenza virus in a mouse model Sialic acid recognition is a key determinant of influenza A virus tropism in murine trachea epithelial cell cultures Effective replication of human influenza viruses in mice lacking a major alpha2,6 sialyltransferase The C-type lectin Langerin functions as a receptor for attachment and infectious entry of influenza A virus Nlinked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN Evolving complexities of influenza virus and its receptors Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads to loss of neuraminidase activity Adaptation of pandemic H1N1 influenza viruses in mice Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus Three mutations switch H7N9 influenza to human-type receptor specificity Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission Influenza H1N1 A/Solomon Island/ 3/06 virus receptor binding specificity correlates with virus pathogenicity, antigenicity, and immunogenicity in ferrets Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic Effects of HA and NA glycosylation pattern changes on the transmission of avian influenza A(H7N9) virus in Guinea pigs The contribution of animal models to the understanding of the host range and virulence of influenza A viruses Animal models for influenza virus transmission studies: a historical perspective Animal models for influenza virus pathogenesis and transmission Bronchointerstitial pneumonia in Guinea pigs following inoculation with H5N1 high pathogenicity avian influenza virus Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a Guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding The Guinea pig as a transmission model for human influenza viruses Syrian hamster as an animal model for the study of human influenza virus infection Animal models in influenza vaccine testing A virus obtained from influenza patients Transmission of influenza B viruses in the Guinea pig Transmission in the Guinea pig model The use of nonhuman primates in research on seasonal, pandemic and avian influenza Pathogenesis of influenza A (H5N1) virus infection in a primate model Experimental production of respiratory tract disease in cebus monkeys after intratracheal or intranasal infection with influenza A/Victoria/3/75 or influenza A/New Jersey/76 virus African green monkeys recapitulate the clinical experience with replication of live attenuated pandemic influenza virus vaccine candidates Evaluation of replication, immunogenicity and protective efficacy of a live attenuated cold-adapted pandemic H1N1 influenza virus vaccine in non-human primates Establishment of a cynomolgus macaque model of influenza B virus infection A single amino acid in the polymerase acidic protein determines the pathogenicity of influenza B viruses Adaptive mutations of neuraminidase stalk truncation and deglycosylation confer enhanced pathogenicity of influenza A viruses Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice DBA/2 mouse as an animal model for anti-influenza drug efficacy evaluation The DBA.2 mouse is susceptible to disease following infection with a broad, but limited, range of influenza A and B viruses Comparison of the pharmacokinetics of several polychlorinated biphenyls in mouse, rat, dog, and monkey by means of a physiological pharmacokinetic model Development of animal models against emerging coronaviruses: from SARS to MERS coronavirus The ferret as a model organism to study influenza A virus infection Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Livestock susceptibility to infection with Middle East respiratory syndrome coronavirus Host determinants of MERS-CoV transmission and pathogenesis Pneumonia from human coronavirus in a macaque model An acute immune response to Middle East respiratory syndrome coronavirus replication contributes to viral pathogenicity Permissivity of dipeptidyl peptidase 4 Orthologs to Middle East respiratory syndrome coronavirus is governed by glycosylation and other complex determinants Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Pre-and postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection A mouse model for MERS coronavirus-induced acute respiratory distress syndrome A human DPP4-Knockin Mouse's susceptibility to infection by authentic and Pseudotyped MERS-CoV Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Lack of Middle East respiratory syndrome coronavirus transmission in rabbits Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Pathogenicity and viral shedding of MERS-CoV in immunocompromised rhesus macaques Infection with MERS-CoV causes lethal pneumonia in the common marmoset Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2 Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein Species-specific Colocalization of Middle East keywords: animal; avian; cov; human; iavs; infection; influenza; mers; mice; pandemic; receptor; swine; tract; transmission; virus; viruses cache: cord-286741-h3oix9zc.txt plain text: cord-286741-h3oix9zc.txt item: #173 of 515 id: cord-287156-3plpi6i9 author: Lassandro, Giuseppe title: Children in Coronaviruses’ Wonderland: What Clinicians Need to Know date: 2020-07-01 words: 8034 flesch: 36 summary: Multisystem Inflammatory Syndrome in Children in COVID-19-associated immune thrombocytopenia Immune Thrombocytopenia (ITP) in a SARS-CoV-2 Positive Pediatric Patient Covid-19 and Children with Immune Thrombocytopenia: Emerging Issues Evans syndrome in a patient with COVID-19 COVID-19 infection associated with autoimmune hemolytic anemia Chest computed tomography in children with COVID-19 respiratory infection Clinical and CT imaging features of the COVID-19 pneumonia: Influenza Other Respir Viruses Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou Human Coronavirus Infections in Israel: Epidemiology, Clinical Symptoms and Summer Seasonality of HCoV-HKU1. keywords: acute; cases; children; clinical; coronavirus; covid-19; disease; east; human; infection; mers; middle; novel; patients; sars; symptoms; syndrome cache: cord-287156-3plpi6i9.txt plain text: cord-287156-3plpi6i9.txt item: #174 of 515 id: cord-287159-bjccnp7u author: Yavarian, Jila title: Influenza virus but not MERS coronavirus circulation in Iran, 2013–2016: Comparison between pilgrims and general population date: 2017-10-12 words: 2745 flesch: 46 summary: The second aim was to assess the prevalence of influenza virus infections in these patients and the final aim was to comparison of influenza and MERS-CoV circulation between general population and pilgrims. Rhinoviruses were detected in half of UK pilgrims, followed by influenza virus but in Saudi pilgrims 78.5% had influenza virus infection keywords: hajj; infections; influenza; mers; pilgrims; study cache: cord-287159-bjccnp7u.txt plain text: cord-287159-bjccnp7u.txt item: #175 of 515 id: cord-287222-wojyisu0 author: Zhou, Min title: Coronavirus disease 2019 (COVID-19): a clinical update date: 2020-04-02 words: 5692 flesch: 34 summary: Unlike influenza pneumonia, which usually exhibited unilateral GGO and significant solid nodules, only 6% of COVID-19 patients had solid nodules A majority of COVID-19 patients showed normal leucocyte count, and nearly one third had leucopenia keywords: china; clinical; coronavirus; covid-19; disease; infection; novel; patients; plasma; pneumonia; sars; study; syndrome; treatment; ventilation cache: cord-287222-wojyisu0.txt plain text: cord-287222-wojyisu0.txt item: #176 of 515 id: cord-287527-ep6ug9c3 author: Algaissi, Abdullah title: Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease date: 2018-09-26 words: 4734 flesch: 43 summary: Tg mice, was developed through mating of hDPP4 +/− mice and used as breeders for generating offspring of both genotypes of hDPP4 Tg mice. ELISA-based and Vero E6 cell-based microneutralization assays, previously described [7] , were used to determine the titers of MERS-CoV RBD-specific serum IgG and neutralizing antibodies in hDPP4 Tg mice in response to MERS-CoV infection. keywords: cov; hdpp4; infection; mers; mice; rshdpp4 cache: cord-287527-ep6ug9c3.txt plain text: cord-287527-ep6ug9c3.txt item: #177 of 515 id: cord-287758-da11ypiy author: Mônica Vitalino de Almeida, Sinara title: COVID-19 therapy: what weapons do we bring into battle? date: 2020-09-10 words: 17493 flesch: 35 summary: More preclinical and clinical studies are required to prove whether dasatinib is really promising for COVID-19 patient treatment. SBV is also combined with other antiviral drugs, such as ledipasvir, velpatasvir and voxilaprevir. keywords: action; activity; antiviral; binding; cells; clinical; coronavirus; cov-2; covid-19; disease; drug; entry; fig; host; human; infection; inhibitor; mechanism; new; novel; patients; potential; pro; protein; receptor; replication; results; rna; sars; studies; study; syndrome; synthesis; targets; therapy; treatment cache: cord-287758-da11ypiy.txt plain text: cord-287758-da11ypiy.txt item: #178 of 515 id: cord-287761-73qgx58i author: Aly, Mahmoud title: Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update date: 2017-10-13 words: 3394 flesch: 50 summary: Next, we sought out the detailed demographic distributions of reported cases among 14 governorates in Saudi Arabia. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an invitro and ex-vivo study Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Infection control and MERS-CoV in health-care workers MERS coronovirus has probably been present in bats for many years, research shows Link to MERS virus underscores bats' puzzling threat Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronavirus neutralizing antibodies in camels Animal models of Middle East respiratory syndrome coronavirus infection MERS-CoV keywords: cases; coronavirus; cov; east; infections; mers; middle; region cache: cord-287761-73qgx58i.txt plain text: cord-287761-73qgx58i.txt item: #179 of 515 id: cord-287886-41isp0wj author: Al-Tawfiq, Jaffar A title: Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia date: 2016-11-08 words: 2273 flesch: 52 summary: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Hospital outbreak of Middle East respiratory syndrome coronavirus Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Taking stock of the first 133 MERS coronavirus cases globally--Is the epidemic changing? State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Family cluster of Middle East respiratory syndrome coronavirus infections A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study MERS-CoV outbreak in Jeddah--a link to health care facilities An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia An update on Middle East respiratory syndrome: 2 years later Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution epidemiological findings from a retrospective investigation The Characteristics of Middle Eastern Respiratory Syndrome Coronavirus Transmission Dynamics in South Korea Microevolution of Outbreak-Associated Middle East Respiratory Syndrome Coronavirus Managing MERS-CoV in the healthcare setting Middle East respiratory syndrome coronavirus disease in children MERS-CoV summary and literature Middle East respiratory syndrome coronavirus (MERS-CoV) Case List of MoH/WHO Novel Coronavirus MERS nCoV Announced Cases Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Middle East respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia Al Abdallat MM. Despite the total number of MERS cases increasing, especially in KSA, the number of pediatric cases remained low during the study period. keywords: cases; coronavirus; cov; mers cache: cord-287886-41isp0wj.txt plain text: cord-287886-41isp0wj.txt item: #180 of 515 id: cord-287953-prn8cnvo author: Shin, Nina title: Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea date: 2017-05-21 words: 6255 flesch: 33 summary: Details of patient room design, costs, and estimated number of infected patients are shown in Table 10 under the parametric settings of the number of beds ( BEDS = 40), the occupancy rate ( α = .85), the number of visitors per patient ( β = 3), and the infectivity rate ( λ low = .01, λ base = .05, λ high = .07). The Korean government has been trying to optimize patient room design by increasing numbers of multi-patient rooms rather than single-patient rooms, in order to minimize overall healthcare cost for its citizens, as announced at the 2015 Health Insurance Policy Review Committee Conference in Seoul. keywords: healthcare; hospital; infection; infectivity; korea; mers; model; number; outbreak; patient; rate; room; system cache: cord-287953-prn8cnvo.txt plain text: cord-287953-prn8cnvo.txt item: #181 of 515 id: cord-288167-976qxja2 author: Park, Wan Beom title: Replicative virus shedding in the respiratory tract of patients with Middle East respiratory syndrome coronavirus infection date: 2018-05-09 words: 1373 flesch: 44 summary: In sputum and transtracheal aspirate, sub-genomic mRNA was detected for up to 4 weeks after symptoms developed, which correlated with the detection of genomic RNA. The objectives of this study were to examine the duration for detecting MERS-CoV sub-genomic mRNA vs. genomic RNA in different respiratory specimens. keywords: cov; genomic; mers; mrna cache: cord-288167-976qxja2.txt plain text: cord-288167-976qxja2.txt item: #182 of 515 id: cord-288389-z0sz1msj author: Fanoy, Ewout B title: Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia, May 2014 date: 2014-10-17 words: 2978 flesch: 53 summary: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin Investigation of an imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in A case of imported Middle East respiratory syndrome coronavirus infection and public health response Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Geographic distribution of MERS coronavirus among dromedary camels Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Human infection with MERS coronavirus after exposure to infected camels Antibodies against MERS coronavirus in dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands World Health Organization: Twelve non-cases drank unpasteurized camel milk and had contact with camels. keywords: case; coronavirus; cov; infection; mers; travellers cache: cord-288389-z0sz1msj.txt plain text: cord-288389-z0sz1msj.txt item: #183 of 515 id: cord-288409-idq780jb author: Alsahafi, Abdullah J. title: Knowledge, Attitudes and Behaviours of Healthcare Workers in the Kingdom of Saudi Arabia to MERS Coronavirus and Other Emerging Infectious Diseases date: 2016-12-06 words: 2620 flesch: 44 summary: Objectives: The aim of this survey was to assess the knowledge, attitudes, infection control practices and educational needs of HCWs in the Kingdom of Saudi Arabia to MERS coronavirus and other emerging infectious diseases. The risk of importation of other emerging infectious diseases, particularly with large population movements during the Hajj and Umrah is also significant. keywords: cov; diseases; hcws; infection; mers cache: cord-288409-idq780jb.txt plain text: cord-288409-idq780jb.txt item: #184 of 515 id: cord-288589-bt9429bh author: Habibzadeh, Farrokh title: Hadj ritual and risk of a pandemic date: 2013-12-31 words: 536 flesch: 50 summary: Emergence of medicine for mass gatherings: lessons from the Hajj Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Middle East respiratory syndrome coronavirus (MERS-CoV), update Middle East respiratory syndrome coronavirus: the unseen menace The first known occurrence of MERS-CoV in human was reported in a patient with severe acute respiratory infection in April 2012, in Jordan. keywords: cov; mers cache: cord-288589-bt9429bh.txt plain text: cord-288589-bt9429bh.txt item: #185 of 515 id: cord-288670-1vlowf2n author: Yang, Naidi title: Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19 date: 2020-03-15 words: 4521 flesch: 40 summary: One key element in viral infection is the process of viral entry into the host cells. A first step in understanding SARS pathogenesis Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN Chloroquine is a potent inhibitor of SARS coronavirus infection and spread SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry Role of endocytosis and low pH in murine hepatitis virus strain A59 cell entry Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level Mouse hepatitis virus type 2 enters cells through a clathrin-mediated endocytic pathway independent of Eps15 Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) keywords: autophagy; cells; coronavirus; cov; covs; entry; infection; pathway; replication; sars cache: cord-288670-1vlowf2n.txt plain text: cord-288670-1vlowf2n.txt item: #186 of 515 id: cord-288859-19jwawrm author: Choi, S. title: High reproduction number of Middle East respiratory syndrome coronavirus in nosocomial outbreaks: mathematical modelling in Saudi Arabia and South Korea date: 2017-09-25 words: 3138 flesch: 52 summary: The KSA and Korean outbreaks were compared using a line listing of MERS cases compiled using publicly available sources. The KSA and Korean outbreaks were compared using a line listing of MERS cases compiled using publicly available sources. keywords: days; mers; model; outbreak cache: cord-288859-19jwawrm.txt plain text: cord-288859-19jwawrm.txt item: #187 of 515 id: cord-289003-vov6o1jx author: Burdet, C. title: Need for integrative thinking to fight against emerging infectious diseases. Proceedings of the 5th seminar on emerging infectious diseases, March 22, 2016 – current trends and proposals date: 2018-02-28 words: 8328 flesch: 44 summary: vov6o1jx Abstract We present here the proceedings of the 5th seminar on emerging infectious diseases, held in Paris on March 22nd, 2016, with seven priority proposals that can be outlined as follows: encourage research on the prediction, screening and early detection of new risks of infection; develop research and surveillance concerning transmission of pathogens between animals and humans, with their reinforcement in particular in intertropical areas (“hot-spots”) via public support; pursue aid development and support in these areas of prevention and training for local health personnel, and foster risk awareness in the population; ensure adapted patient care in order to promote adherence to treatment and to epidemic propagation reduction measures; develop greater awareness and better education among politicians and healthcare providers, in order to ensure more adapted response to new types of crises; modify the logic of governance, drawing from all available modes of communication and incorporating new information-sharing tools; develop economic research on the fight against emerging infectious diseases, taking into account specific driving factors in order to create a balance between preventive and curative approaches. Seven priority proposals can be outlined as follows: encourage research on the prediction, screening and early detection of new risks of infection; develop research and surveillance concerning transmission of pathogens between animals and humans, with their reinforcement in particular in intertropical areas ('hot-spots') thanks to public support; pursue aid development and support in these areas of prevention and training for local health personnel, and to foster risk awareness in the population; ensure adapted patient care in order to promote adherence to treatment and to epidemic propagation reduction measures; develop greater sensitization and training among politicians and healthcare providers, in order to better prepare them to respond to new types of crises; modify the logic of governance, drawing from all available modes of communication and incorporating new information-sharing tools; develop economic research on the fight against EIDs, taking into account specific determining factors in order to create a balance between preventive and treatment approaches. keywords: animal; areas; case; cov; emergence; epidemic; health; healthcare; human; management; public; risk; state; transmission; virus cache: cord-289003-vov6o1jx.txt plain text: cord-289003-vov6o1jx.txt item: #188 of 515 id: cord-289096-wuegn0jg author: Wang, Liang title: Bat-Origin Coronaviruses Expand Their Host Range to Pigs date: 2018-04-18 words: 1212 flesch: 53 summary: Instead, two genomes of novel SeACoV were detected in the ill piglets by two independent groups, and preliminary analysis showed that the SeACoVs possibly originated from bat HKU coronaviruses Given that pigs are in frequent contact with human and multiple wildlife species, and that pork is one of the most commonly consumed meats in non-Muslim countries, it is important to assess whether pigs could be mixing vessels for the emergence of novel coronaviruses with high agricultural impact and risks to public health. keywords: bat; coronaviruses; pigs cache: cord-289096-wuegn0jg.txt plain text: cord-289096-wuegn0jg.txt item: #189 of 515 id: cord-289311-0wgafqdz author: Kim, Jee-Eun title: Neurological Complications during Treatment of Middle East Respiratory Syndrome date: 2017-06-30 words: 3560 flesch: 39 summary: Critical-illness polyneuropathy/myopathy appears frequently in ICU patients but was not thought JCN to be present in patient 1 because ophthalmoparesis and ptosis are very rare in critical-illness polyneuropathy/myopathy. However, we considered it unlikely that Wernicke's encephalopathy was present in patient 1 for several reasons: 1) he showed none of the typical changes associated with Wernicke's encephalopathy in brain MRI, which has particularly high sensitivity (97-100%) in patients without alcohol abuse, 17 2) the ptosis and complete ophthalmoplegia that were observed in this patient are rare in Wernicke's encephalopathy, 18 and 3) thiamine deficiency was not confirmed in laboratory tests and the patient did not have dietary deficiencies or alcoholism. keywords: cov; mers; patients; symptoms; syndrome; treatment; weakness cache: cord-289311-0wgafqdz.txt plain text: cord-289311-0wgafqdz.txt item: #190 of 515 id: cord-289520-i6pv90s9 author: Harris, Carlyn title: An evidence-based framework for priority clinical research questions for COVID-19 date: 2020-03-31 words: 4709 flesch: 42 summary: Three bibliographic databases were searched to identify clinical studies published on SARS-CoV and MERS-CoV in the outbreak setting. Overall, clinical characterisation studies commonly found bilateral involvement with ground glass opacity, though a range of presentations were reported [8] [9] [10] 15] . keywords: coronavirus; covid-19; health; mers; novel; outbreak; patients; research; sars; studies cache: cord-289520-i6pv90s9.txt plain text: cord-289520-i6pv90s9.txt item: #191 of 515 id: cord-289535-srrfr1es author: Tregoning, J. S. title: Vaccines for COVID‐19 date: 2020-10-18 words: 14346 flesch: 38 summary: Identity of blood and tissue leukocytes supporting in vitro infection New insights into the immunopathology and control of dengue virus infection Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection Molecular mechanism for antibodydependent enhancement of coronavirus entry A perspective on potential antibody-dependent enhancement of SARS-CoV-2 Is there an ideal animal model for SARS? Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase Caution urged on SARS vaccines Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus Development of animal models against emerging coronaviruses: from SARS to MERS coronavirus Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice SARS-CoV-2 infection in farmed minks, the Netherlands Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 Reinfection could not occur in SARS-CoV-2 infected rhesus macaques Ethical guidelines for deliberately infecting volunteers with COVID-19 Human challenge studies to accelerate coronavirus vaccine licensure SARS-CoV-2 controlled human infection models: ethics, challenge agent production and regulatory issues Effect of dexamethasone in hospitalized patients with COVID-19 Criner GJet al, for the GSUSI. Clinical vaccine trials conventionally undergo four broad Phases, from early safety in small numbers of volunteers (Phase I) to wide-scale post-licensure monitoring (Phase IV). keywords: antibodies; antibody; cell; challenge; coronavirus; cov-2; covid-19; development; disease; dna; human; immune; immunity; infection; mers; mice; phase; protein; responses; rna; sars; spike; studies; syndrome; trials; vaccination; vaccine; virus cache: cord-289535-srrfr1es.txt plain text: cord-289535-srrfr1es.txt item: #192 of 515 id: cord-290319-decr6wrd author: Kayali, Ghazi title: A more detailed picture of the epidemiology of Middle East respiratory syndrome coronavirus date: 2015-05-31 words: 1621 flesch: 42 summary: One concern with school-based programmes is the Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional serological study Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia MERS-CoV): summary of current situation, literature update and risk assessment Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Close relative of human Middle East respiratory syndrome coronavirus in bat MERS-Related Betacoronavirus in Vespertilio Superans bats Middle East respiratory syndrome: An emerging coronavirus infection tracked by the crowd MERS coronaviruses in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Investigation of anti-middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, fall 2012 Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 Lack of Middle East respiratory syndrome coronavirus transmission from infected camels Acute Middle East respiratory syndrome coronavirus infection in livestock dromedaries Evidence is accumulating that dromedary camels are a natural host of MERS-CoV. Serological fi ndings suggest that more than 90% of adult dromedaries in the Middle East and Africa are seropositive for MERS-CoV. 7 The virus isolated from dromedaries has spike proteins with conserved receptor-binding domains for the human dipeptidyl peptidase-4 receptor, 8, 9 and MERS-CoV has been detected in camels that were in close contact with people with Middle East respiratory syndrome. keywords: cov; east; mers; vaccination cache: cord-290319-decr6wrd.txt plain text: cord-290319-decr6wrd.txt item: #193 of 515 id: cord-290744-m0vpizuh author: Kindler, E. title: Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response date: 2016-09-09 words: 7239 flesch: 32 summary: Translation is initiated at the start codon of ORF1a and may continue to ORF1b via a ribosomal frameshift mechanism, ultimately giving rise to two overlapping replicase polyproteins pp1a and pp1ab Perlman and Netland, 2009; Snijder et al., 2003; Thiel et al., 2003) . Moreover, ORF1b harbors several RNA-processing enzymes, including a 3 0 -5 0 exonuclease and a guanosine N7-methyltransferase (associated with the N-and C-terminal domains, respectively, of nsp14), an endoribonuclease (nsp15) and a 2 0 -O-methyltransferase (nsp16) (Chen et al., 2009; Decroly et al., 2008; Ivanov et al., 2004; Kindler and Thiel, 2014; Minskaia et al., 2006; Perlman and Netland, 2009; Snijder et al., 2003; Thiel et al., 2003; Zust et al., 2011) . keywords: antiviral; cells; coronavirus; cov; et al; host; human; ifn; induction; interferon; mers; pkr; protein; respiratory; rna; sars; syndrome; type cache: cord-290744-m0vpizuh.txt plain text: cord-290744-m0vpizuh.txt item: #194 of 515 id: cord-291014-cfnoxhtd author: Zheng, Jian title: Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host date: 2018-02-28 words: 4404 flesch: 21 summary: Nevertheless, the role of epigenetic modification during respiratory virus infection is not well understood; the application of phosphoproteomics to characterization of the human macrophage response to IAV infection [113] serves as a model for future studies. [63] Nuclear import and export machinery IAV IAV have evolved different mechanisms to utilize importin-alpha isoforms, affecting importation on both sides of the nuclear envelope. keywords: cells; cov; host; iav; infection; influenza; memory; mers; protein; responses; role; sars; virus; viruses cache: cord-291014-cfnoxhtd.txt plain text: cord-291014-cfnoxhtd.txt item: #195 of 515 id: cord-291199-nazl2e97 author: Kleine-Weber, Hannah title: Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization date: 2018-11-07 words: 5844 flesch: 38 summary: Whole-cell lysates (WCL) were prepared from transfected cells, and S protein expression was analyzed by SDS-PAGE and immunoblotting using anti-V5 antibody reactive against the V5 epitope at the C terminus of the S proteins. The particles were subsequently pelleted by centrifugation through a sucrose cushion and analyzed for S protein expression by SDS-PAGE and immunoblotting. keywords: cells; coronavirus; cov; d510; dpp4; east; entry; i529; mers; middle; protein cache: cord-291199-nazl2e97.txt plain text: cord-291199-nazl2e97.txt item: #196 of 515 id: cord-291367-rtmsrh16 author: Zumla, Alimuddin title: Middle East Respiratory Syndrome - need for increased vigilance and watchful surveillance for MERS-CoV in sub-Saharan Africa date: 2015-07-02 words: 2263 flesch: 36 summary: -Saudi Arabia The Hajj pilgrimage and surveillance for Middle East Respiratory syndrome coronavirus in pilgrims from African countries High prevalence of common respiratory viruses and no evidence of Middle East Respiratory Syndrome Coronavirus in Hajj pilgrims returning to Ghana Hajj: infectious disease surveillance and control Travel implications of emerging coronaviruses: SARS and MERS-CoV Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program An update on Middle East respiratory syndrome: 2 years later Pilgrims and MERS-CoV: what's the risk? KSA MERS-CoV Investigation Team. Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle East Respiratory Syndromeadvancing the public health and research agenda on MERS-lessons from the South Korea outbreak Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers Infection prevention and control of epidemic-and pandemicprone acute respiratory infections in health care -WHO Guidelines. keywords: cov; east; mers; middle; respiratory; syndrome cache: cord-291367-rtmsrh16.txt plain text: cord-291367-rtmsrh16.txt item: #197 of 515 id: cord-291590-24psoaer author: Ogando, Natacha S. title: The enzymatic activity of the nsp14 exoribonuclease is critical for replication of Middle East respiratory syndrome-coronavirus date: 2020-06-20 words: 4335 flesch: 33 summary: Part A: 882 Emergence of the hypercycle Viral quasispecies evolution Mutational fitness effects in RNA and single-stranded DNA viruses: common 886 patterns revealed by site-directed mutagenesis studies Viral mutation rates Lack of evidence for proofreading mechanisms 891 associated with an RNA virus polymerase Mutation rates among RNA viruses Error catastrophe and antiviral strategy Selforganization of matter and the evolution of biological macromolecules Discovery of the first 899 insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus 900 genomes The 902 footprint of genome architecture in the largest genome expansion in RNA viruses A planarian 905 nidovirus expands the limits of RNA genome size Description and 907 initial characterization of metatranscriptomic nidovirus-like genomes from the proposed new 908 family Abyssoviridae, and from a sister group to the Coronavirinae, the proposed genus 909 Alphaletovirus Unique and conserved features of genome and proteome of SARS-912 coronavirus, an early split-off from the coronavirus group 2 lineage Exoribonuclease superfamilies: structural analysis and 914 phylogenetic distribution Purification and characterization of Escherichia coli RNase 916 T Structural basis for the 3'-5' exonuclease activity of Escherichia coli 918 DNA polymerase I: a two metal ion mechanism A general two-metal-ion mechanism for catalytic RNA 922 Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA 923 synthesis Structural basis 925 and functional analysis of the SARS coronavirus nsp14-nsp10 complex Structural and molecular basis of mismatch correction 929 and ribavirin excision from coronavirus RNA High fidelity of murine hepatitis virus 931 replication is decreased in nsp14 exoribonuclease mutants Infidelity of SARS-CoV Nsp14-exonuclease mutant 934 virus replication is revealed by complete genome sequencing A live, impaired-936 fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal 937 disease keywords: activity; coronavirus; cov; exon; fig; mers; nsp14; replication; rna; sars cache: cord-291590-24psoaer.txt plain text: cord-291590-24psoaer.txt item: #198 of 515 id: cord-291650-1qy6y7f0 author: Butt, Taimur S. title: Infection control and prevention practices implemented to reduce transmission risk of Middle East respiratory syndrome-coronavirus in a tertiary care institution in Saudi Arabia date: 2016-05-01 words: 2879 flesch: 39 summary: We propose advanced infection control measures (A-IC) used in conjunction with basic infection control measures (B-IC) help reduce pathogen transmission. Basic infection control measures (B-IC), defined as standard and transmissionbased precautions, play a major role in preventing and controlling pathogen spread, including adherence to hand hygiene, environment and equipment cleanliness, use of personal protective equipment (PPE) such as high-efficiency particulate respirators (eg, N-95 or R-95), and adhering to respiratory/cough etiquette. keywords: cases; control; cov; hcws; infection; measures; mers cache: cord-291650-1qy6y7f0.txt plain text: cord-291650-1qy6y7f0.txt item: #199 of 515 id: cord-291679-jfxqipt8 author: Yang, Seongwoo title: Middle East respiratory syndrome risk perception among students at a university in South Korea, 2015 date: 2017-06-01 words: 5629 flesch: 43 summary: Older age was negatively associated with risk perception 2 (concern over contracting MERS through indirect contact) (β = −0.07; P = .004) and positively associated with risk perceptions 4 (considering MERS to be more severe than other respiratory diseases) (β = 0.09; P < .001), 6 (concern over damage to the community because of MERS) Women showed higher risk perception than men, and trust in the media was positively associated with risk perception (P < .001). keywords: knowledge; media; mers; perception; public; risk; risk perception; trust cache: cord-291679-jfxqipt8.txt plain text: cord-291679-jfxqipt8.txt item: #200 of 515 id: cord-291694-nokowfdi author: Wickramage, Kolitha title: “Don’t forget the migrants”: exploring preparedness and response strategies to combat the potential spread of MERS-CoV virus through migrant workers in Sri Lanka date: 2013-07-29 words: 3691 flesch: 44 summary: Based on the fact that 71% of the current caseload of Sri Lankan migrant workers depart for the KSA, it is expected that the majority of inbound migrants will be traveling from the same country. The Gulf-Approved Medical Centers Association (GAMCA) has a network of 13 private medical centers in Sri Lanka, which are accredited to conduct health assessments of Sri Lankan migrant workers prior to departure to the GAMCA countries KSA, Kuwait, Bahrain, Qatar, UAE and Oman. keywords: cov; health; labor; lanka; mers; middle; migrant; sri; workers cache: cord-291694-nokowfdi.txt plain text: cord-291694-nokowfdi.txt item: #201 of 515 id: cord-291916-5yqc3zcx author: Hozhabri, Hossein title: The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting date: 2020-08-05 words: 16799 flesch: 39 summary: This form of adaptation required a series of amino acid changes in the RBD within the S protein of SARS viruses that circulated in bats [56, 68] . Strategies for controlling emerging coronaviruses A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice Cross-species transmission of the newly identified coronavirus 2019-nCoV Towards a solution to MERS: keywords: ace2; acute; cases; cell; china; coronavirus; cov-2; covid-19; days; diagnosis; disease; figure; genome; host; human; infection; mers; novel; patients; pneumonia; protein; receptor; rna; sars; study; symptoms; syndrome; transmission; vaccine cache: cord-291916-5yqc3zcx.txt plain text: cord-291916-5yqc3zcx.txt item: #202 of 515 id: cord-292041-a65kfw80 author: Orienti, Isabella title: Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment in COVID-19 date: 2020-05-27 words: 6133 flesch: 29 summary: Pulmonary formulations of anti-inflammatory drugs could represent a good option in combination with systemic antiviral drugs or glucocorticoids. It decreased the infiltration of inflammatory cells and inhibited the production of inflammatory cytokines [84] . keywords: activity; cells; cov; cov-2; covid-19; drugs; fenretinide; infection; lung; pulmonary; response; sars; treatment; virus cache: cord-292041-a65kfw80.txt plain text: cord-292041-a65kfw80.txt item: #203 of 515 id: cord-292092-o6s5nw49 author: Furuse, Yuki title: Conservation of nucleotide sequences for molecular diagnosis of Middle East respiratory syndrome coronavirus, 2015 date: 2015-09-30 words: 1233 flesch: 52 summary: The numbers of viral sequences that matched the primer/ probe sequences perfectly were counted. In addition, viral sequences of the reverse primer region for the NSeq assay were not highly conserved; the sequence matched only 49% of strains. keywords: assay; cov; mers cache: cord-292092-o6s5nw49.txt plain text: cord-292092-o6s5nw49.txt item: #204 of 515 id: cord-292709-4hn55wui author: Nor, Mohd Basri Mat title: Pneumonia in the tropics: Report from the Task Force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine date: 2017-12-31 words: 4561 flesch: 41 summary: Patients who meet clinical and epidemiological criteria should be tested for H5N1 avian influenza infection. Influenza viruses which are classified by their core proteins (i.e. A, B or C) and belong to the family orthomyxoviridae, cause predominantly respiratory disease in humans. keywords: avian; cases; disease; infection; influenza; patients; plague; pneumonia; syndrome; treatment; viruses cache: cord-292709-4hn55wui.txt plain text: cord-292709-4hn55wui.txt item: #205 of 515 id: cord-292836-1o2ynvy3 author: Ogimi, Chikara title: What’s New With the Old Coronaviruses? date: 2020-04-21 words: 5200 flesch: 41 summary: Frequency of and relationship between outbreaks of coronavirus infection Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare Epidemiology of multiple respiratory viruses in childcare attendees Community surveillance of respiratory viruses among families in the Utah Better Identification of Germs-Longitudinal Viral Epidemiology (BIG-LoVE) study Seroepidemiologic survey of coronavirus (strain 229E) infections in a population of children Severity and outcome associated with human coronavirus OC43 infections among children New Vaccine Surveillance Network. Human coronavirus in young children hospitalized for acute respiratory illness and asymptomatic controls Community study of role of viral infections in exacerbations of asthma in 9-11 year old children The pediatric burden of human coronaviruses evaluated for twenty years Coronavirus-associated pneumonia in previously healthy children Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China Epidemiology and clinical features of human coronaviruses in the pediatric population Characteristics and outcomes of coronavirus infection in children: the role of viral factors and an immunocompromised state Genetic variability of human coronavirus OC43-, 229E-, and NL63-like strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction Viral upper respiratory tract infection and otitis media complication in young children Croup is associated with the novel coronavirus NL63 Role of human coronavirus NL63 in hospitalized children with croup Human coronavirus OC43 pneumonia in a pediatric cancer patient with Down syndrome and acute lymphoblastic leukemia Fatal respiratory distress syndrome due to coronavirus infection in a child with severe combined immunodeficiency Coronavirus 229E-related pneumonia in immunocompromised patients Fatal lower respiratory tract disease with human corona virus NL63 in an adult haematopoietic cell transplant recipient A multicenter consortium to define the epidemiology and outcomes of inpatient respiratory viral infections in pediatric hematopoietic stem cell transplant recipients Clinical significance of human coronavirus in bronchoalveolar lavage samples from hematopoietic cell transplant recipients and patients with hematologic malignancies Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients Prolonged shedding of human coronavirus in hematopoietic cell transplant recipients: risk factors and viral genome evolution Parallel evolution of influenza across multiple spatiotemporal scales Detection of human coronaviruses in children with acute gastroenteritis Detection of human coronaviruses in simultaneously collected stool samples and nasopharyngeal swabs from hospitalized children with acute gastroenteritis Human coronavirus OC43 associated with fatal encephalitis Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis The role of human coronaviruses in children hospitalized for acute bronchiolitis, acute gastroenteritis, and febrile seizures: a 2-year prospective study Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Canadian Severe Acute Respiratory Syndrome Study Team. keywords: children; coronavirus; hcov; human; infection; patients; sars; study; syndrome; viruses cache: cord-292836-1o2ynvy3.txt plain text: cord-292836-1o2ynvy3.txt item: #206 of 515 id: cord-293127-c27qh5y7 author: Monteleone, Pedro AA title: A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments date: 2020 words: 4519 flesch: 37 summary: The same day, the American Society for Reproductive Medicine (ASRM) published a bulletin suggesting that patients who are highly likely to suffer from COVID-19 (i.e., patients who were tested SARS-CoV-2 positive or who have been exposed to confirmed COVID-19 cases within 14 days of onset of their symptoms) should consider freezing oocytes or embryos and avoid embryo transfer until they are symptom-free; however, this recommendation was emphasized to not necessarily apply to suspected COVID-19 cases as symptoms of COVID-19 closely resemble those of other more common forms of respiratory disease (ASRM, 2020a). On March 15 2020, COVID-19 cases have been detected in all 30 countries of the European Union/European Economic Area and in the United Kingdom with a total of 39,768 cases and 1,727 deaths, of which 17,775 cases and 1,441 deaths occurred in Italy alone (European Centre for Disease Prevention and Control, 2020) . keywords: cases; coronavirus; cov-2; covid-19; infection; patients; pregnancy; sars; women cache: cord-293127-c27qh5y7.txt plain text: cord-293127-c27qh5y7.txt item: #207 of 515 id: cord-293481-bmfj50fb author: Malin, Jakob J. title: Remdesivir against COVID-19 and Other Viral Diseases date: 2020-10-14 words: 9125 flesch: 37 summary: They found that the activity of remdesivir includes both contemporary human and highly divergent zoonotic CoVs and that natural variations in wild-type RdRp do not confer remdesivir resistance. Recently, the efficacy of remdesivir treatment was finally tested in a rhesus macaque model of SARS-CoV-2 infection (53) . keywords: antiviral; cell; clinical; cov-2; covid-19; data; drug; efficacy; mers; nucleoside; patients; remdesivir; rna; sars; study; treatment; trial; virus cache: cord-293481-bmfj50fb.txt plain text: cord-293481-bmfj50fb.txt item: #208 of 515 id: cord-293505-1t3hg4wi author: Bernard-Stoecklin, Sibylle title: Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017 date: 2019-05-14 words: 4167 flesch: 38 summary: Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. After Cardiac Operations An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Hospital outbreak of Middle East respiratory syndrome coronavirus Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia MERS outbreak in Korea: hospital-to-hospital transmission Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from MERS: keywords: cases; coronavirus; cov; east; mers; middle; outbreaks; syndrome cache: cord-293505-1t3hg4wi.txt plain text: cord-293505-1t3hg4wi.txt item: #209 of 515 id: cord-293525-c7nwygl1 author: Saldanha, I. F. title: Extension of the known distribution of a novel clade C betacoronavirus in a wildlife host date: 2019-04-03 words: 5044 flesch: 44 summary: [30] , thus making any association difficult to detect should it occur with EriCoV infection in the hedgehog. Experimental infection studies and the development of in situ hybridisation to localise EriCoV in tissues would be worthwhile in the future to further elucidate the clinical significance of EriCoV infection. keywords: association; coronavirus; ericov; faeces; hedgehogs; infection; rna; samples; sequence; species; wildlife cache: cord-293525-c7nwygl1.txt plain text: cord-293525-c7nwygl1.txt item: #210 of 515 id: cord-293691-ewerquin author: Sauerhering, Lucie title: Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice date: 2020-07-02 words: 3438 flesch: 38 summary: Moreover, we for the first time provide evidence that CsA triggered the activation of an antiviral defense state in lung epithelial cells. These data indicate that CsA treatment mounts a distinct interferon-driven antiviral response in lung epithelial cells. keywords: cells; coronavirus; cov; csa; figure; human; infection; interferon; irf1; mers; syndrome cache: cord-293691-ewerquin.txt plain text: cord-293691-ewerquin.txt item: #211 of 515 id: cord-293871-hzes7mwt author: McGuinness, Sarah L. title: Pretravel Considerations for Non-vaccine-Preventable Travel Infections date: 2018-11-26 words: 4023 flesch: 38 summary: 41 Long-term sequelae of chikungunya virus disease: a systematic review Zika: the origin and spread of a mosquito-borne virus Zika virus: history of a newly emerging arbovirus Zika virus outbreak on Yap Island, Federated States of Micronesia Zika virus Epidemiology, prevention, and potential future treatments of sexually transmitted Zika virus infection Zika virus classification tables Fatal Zika virus infection with secondary nonsexual transmission Estimated incubation period for Zika virus disease Persistence of Zika virus in body fluids-preliminary report Congenital Zika virus infection beyond neonatal microcephaly Update: interim guidance for health care providers caring for pregnant women with possible Zika virus exposure-United States (including US territories) World Health Organization. 28 Pregnant women possibly exposed to ZIKV due to travel or sexual contact should discuss the potential exposure with their Although no vaccines are available at this time for prevention of MERS and avian influenza (H5N1 and H7N9) in travelers, providers should routinely review the most recent epidemiology of severe respiratory infections reported by authorities such as the WHO and CDC (see Table 7 .1) and promote general hygiene and other preventative measures to travelers to these areas (Box 7.2). keywords: chikungunya; dengue; infections; influenza; mers; transmission; travelers; virus; zika cache: cord-293871-hzes7mwt.txt plain text: cord-293871-hzes7mwt.txt item: #212 of 515 id: cord-293938-40zyv1h8 author: Jonsdottir, Hulda R. title: Coronaviruses and the human airway: a universal system for virus-host interaction studies date: 2016-02-06 words: 5536 flesch: 34 summary: Tracheobronchial HAE cultures recapitulate the primary entry point of human respiratory viruses while the alveolar model allows for elucidation of mechanisms involved in viral infection and pathogenesis in the alveoli. This model is a universal platform to study human respiratory viruses [67] keywords: cells; coronavirus; cov; cultures; disease; hcov; human; mers; respiratory; sars; syndrome; viruses cache: cord-293938-40zyv1h8.txt plain text: cord-293938-40zyv1h8.txt item: #213 of 515 id: cord-293966-5c466xvz author: Fehr, Anthony R. title: Bacterial Artificial Chromosome-Based Lambda Red Recombination with the I-SceI Homing Endonuclease for Genetic Alteration of MERS-CoV date: 2019-09-14 words: 3813 flesch: 58 summary: CoV BAC plasmids contain a CMV promoter 5 0 of the viral genome, allowing for transcription of the viral genome following transfection of BAC DNA into mammalian cells. We have tested the Xtra Midi Kit side by side with a BAC-prep kit and found little to no difference in CoV BAC DNA yield. keywords: bac; cells; cov; dna; mers; pcr; recombination; scei; sequence; virus cache: cord-293966-5c466xvz.txt plain text: cord-293966-5c466xvz.txt item: #214 of 515 id: cord-294349-ps3qlho2 author: Al-Sharif, Eman title: Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye date: 2020-09-03 words: 7059 flesch: 40 summary: In a previous case-control study conducted in China among healthcare providers who were taking care of SARS patients, all the 69 providers adhering to the four infection control measures (gown, gloves, mask and hand hygiene practices) did not contract the infection, while all the 13 infected staff omitted at least one of the four control measures [65] . In terms of ocular manifestations, a study published by Wu and colleagues on ocular findings in COVID-19 patients showed that approximately one-third of patients (12/38, 31.6%) had eye manifestations such as conjunctival redness, chemosis, tearing and increased secretions. keywords: conjunctival; coronavirus; cov-2; covid-19; disease; eye; human; infection; mers; patients; sars; studies; symptoms; transmission cache: cord-294349-ps3qlho2.txt plain text: cord-294349-ps3qlho2.txt item: #215 of 515 id: cord-294656-sx3tpe0y author: Lee, Jonggul title: A dynamic compartmental model for the Middle East respiratory syndrome outbreak in the Republic of Korea: A retrospective analysis on control interventions and superspreading events date: 2016-11-07 words: 5275 flesch: 46 summary: In this work, we develop a mathematical model that is consistent with consolidated retrospective investigations of previous MERS outbreaks. Such interventions could prevent the occurrence of SSEs because the potential superspreaders were immediately isolated after being confirmed with MERS infection. keywords: cases; control; duration; korea; mers; outbreak cache: cord-294656-sx3tpe0y.txt plain text: cord-294656-sx3tpe0y.txt item: #216 of 515 id: cord-294800-akr4f5p8 author: Kabir, Md. Tanvir title: nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics date: 2020-07-10 words: 14110 flesch: 33 summary: Recently, it has been observed that nCOVID-19 might predispose to both arterial and venous thromboembolic disease because of immobilization, hypoxia, inflammation, and diffuse intravascular coagulation Guan et al., 2020; Klok et al., 2020; Wang et al., 2020a; Zhou et al., 2020) . Also, the derivatives of teicoplanin including telavancin, dalbavancin, and oritavancin, were also found to block the entry of SARS, MERS, and Ebola viruses (Zhou et al., 2016) . keywords: acute; antiviral; cells; coronavirus; cov-2; day; disease; drug; et al; host; human; individuals; infection; influenza; mers; ncovid-19; novel; patients; pneumonia; protein; response; sars; studies; study; syndrome; transmission; treatment; use; vitamin cache: cord-294800-akr4f5p8.txt plain text: cord-294800-akr4f5p8.txt item: #217 of 515 id: cord-294831-pem059zk author: Zhang, Ling-Pu title: Focus on a 2019-novel coronavirus (SARS-CoV-2) date: 2020-06-11 words: 6212 flesch: 49 summary: SARS-CoV-2 envelope (E) protein, matrix protein, accessory proteins p6 and p8, nonstructural protein 7 (nsp7), and nsp13 are homologous with those of SARS virus SARS-CoV-2 has 82% nucleotide identity with human SARS-CoV and 96% nucleotide identity with bat SARS coronavirus (SARSr-CoV-RaTG13). keywords: antiviral; china; coronavirus; cov-2; covid-19; infection; mers; ncov; novel; patients; pneumonia; rate; sars; study cache: cord-294831-pem059zk.txt plain text: cord-294831-pem059zk.txt item: #218 of 515 id: cord-294854-rvrgcugn author: Hu, Biying title: The cytokine storm and COVID‐19 date: 2020-06-27 words: 2788 flesch: 33 summary: Potential for global spread of a novel coronavirus from China Clinical features of patients infected with 2019 novel coronavirus in Wuhan An interferon-gamma-related cytokine storm in SARS patients Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis COVID-19: consider cytokine storm syndromes and immunosuppression Chapter Eight -Hosts and Sources of Endemic Human Coronaviruses Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. Pathological alterations in COVID-19 patients include pulmonary edema, diffuse alveolar injury with the formation of hyaline membranes, the presence of reactive type II pneumocyte hyperplasia, proteinaceous aggregates, fibrinous Accepted Article exudates, monocytes and macrophages within alveolar spaces, and inflammatory infiltration of interstitial mononuclear cells [25] [26] keywords: acute; coronavirus; cov-2; covid-19; cytokine; patients; sars; storm; syndrome cache: cord-294854-rvrgcugn.txt plain text: cord-294854-rvrgcugn.txt item: #219 of 515 id: cord-294856-eeh2a0t8 author: Lambert, Paul-Henri title: Consensus Summary Report for CEPI/BC March 12-13, 2020 Meeting: Assessment of Risk of Disease Enhancement with COVID-19 Vaccines date: 2020-05-25 words: 5249 flesch: 32 summary: Virology Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH-and cysteine protease-independent FcgammaR pathway Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets Animal models and antibody assays for evaluating candidate SARS vaccines: summary of a technical meeting 25-26 Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates Correction: Immunodominant SARS Coronavirus Epitopes in Humans Elicited Both Enhancing and Neutralizing Effects on Infection in Non-human Primates Immunogenicity and protective efficacy in monkeys of purified inactivated Verocell SARS vaccine. In murine models, evidence for vaccine related disease enhancement has been demonstrated for inactivated whole vaccine (with and without alum), vectored vaccine expressing N protein (but not seen with vectored vaccine expressing S protein in same report), a replicon particle platform expressing S protein, and a vectored vaccine expressing S proteins. keywords: animal; challenge; coronavirus; cov-2; disease; enhancement; mice; models; response; sars; vaccine; virus cache: cord-294856-eeh2a0t8.txt plain text: cord-294856-eeh2a0t8.txt item: #220 of 515 id: cord-294907-i836d6im author: Alabdali, Abdullah title: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak at King Abdul-Aziz Medical City-Riyadh from Emergency Medical Services Perspective date: 2020-05-20 words: 3297 flesch: 44 summary: The high mortality rate in MERS-CoV and high health-care-associated infections, including health care personnel acquired infections, required local hospitals to ensure that ambulance services personnel understand the risk of transporting such patients. This article reported the overall experience of a Saudi hospitalbased Emergency Medical Services (EMS) system with MERS-CoV: logistics of transfer, transfer policies, methods of monitoring personnel with CoV exposure, and training provided to EMS personnel. keywords: ambulance; cases; cov; ems; medical; mers; outbreak; patients cache: cord-294907-i836d6im.txt plain text: cord-294907-i836d6im.txt item: #221 of 515 id: cord-294918-lm2ixz8n author: Hotez, Peter J. title: Calling for rapid development of a safe and effective MERS vaccine date: 2014-07-31 words: 1096 flesch: 32 summary: To date, however, the level of interest from scientific funding agencies to develop MERS vaccines has been modest. The receptor-binding domain (RBD) in the S protein S1 subunit contains major neutralizing epitopes, serving as an attractive target for MERS vaccine [14] . keywords: cov; mers; protein; vaccine cache: cord-294918-lm2ixz8n.txt plain text: cord-294918-lm2ixz8n.txt item: #222 of 515 id: cord-295375-nakxfhxk author: Yu, Yang title: Assessment of the quality of systematic reviews on COVID‐19: A comparative study of previous coronavirus outbreaks date: 2020-04-28 words: 2459 flesch: 34 summary: Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Clinical outcomes of current medical approaches for Middle East respiratory syndrome: a systematic review and meta-analysis Femoral head necrosis after severe acute respiratory syndrome: etiology and treatment MERS transmission and risk factors: a systematic review Global status of Middle East respiratory syndrome coronavirus in dromedary camels: a systematic review SARS: systematic review of treatment effects A systematic review of assessing the effect of integrated traditional Chinese medicine with western medicine for severe acute respiratory syndrome Effect of integrated traditional Chinese and Western medicine on SARS: a review of clinical evidence Systematic assessment on the effect of integrated Chinese traditional medicine with western medicine in the treatment of severe acute respiratory syndrome (SARS) Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis Transmission of Middle East respiratory syndrome coronavirus infections among healthcare personnel in the Middle East: a systematic review Evidence-based rapid review on possibility of treatment of 2019-nCoV with subcutaneous α-interferon A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 The possibility of using Lopinave/ Litonawe (LPV/r) as treatment for novel coronavirus (2019-nCov) pneumonia: a quick systematic review based on earlier coronavirus clinical studies Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China COVID-19 patients' clinical characteristics, discharge rate and fatality rate of meta-analysis Sanchis-Gomar F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a metaanalysis Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a metaanalysis Potential rapid diagnostics, vaccine and therapeutics for 2019 novel coronavirus (2019-nCoV): a systematic review Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients Clinical characteristics of hospitalized patients with SARS-CoV-2 infection: a single arm metaanalysis Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option Potential interventions for novel coronavirus in China: a systematic review Traditional Chinese medicine syndromes of the novel coronavious pneumonica: a systemic review and meta-analysis The Possibility of Ribavirinas in the Treatment of the Coronavirus Disease 2019: a Systematic Review The influence of the team in conducting a systematic review Analysis of the time and workers needed to conduct systematic reviews of medical interventions using data from the PROSPERO registry European Centre for Disease Prevention and Control. key: cord-295375-nakxfhxk authors: Yu, Yang; Shi, Qianling; Zheng, Peng; Gao, Lei; Li, Haiyuan; Tao, Pengxian; Gu, Baohong; Wang, Dengfeng; Chen, Hao title: Assessment of the quality of systematic reviews on COVID‐19: A comparative study of previous coronavirus outbreaks date: 2020-04-28 journal: J Med Virol DOI: 10.1002/jmv.25901 sha: doc_id: 295375 cord_uid: nakxfhxk Several systematic reviews (SRs) have been conducted on the COVID‐19 outbreak, which together with the SRs on previous coronavirus outbreaks, form important sources of evidence for clinical decision and policy making. keywords: coronavirus; quality; review; sars; srs; syndrome cache: cord-295375-nakxfhxk.txt plain text: cord-295375-nakxfhxk.txt item: #223 of 515 id: cord-295433-olmein3q author: Banerjee, Arinjay title: Bats and Coronaviruses date: 2019-01-09 words: 5661 flesch: 47 summary: Unlike the amount of information available from studies of other bat viruses such as Nipah, Hendra, Ebola, and Marburg viruses, we know very little, if anything about how coronaviruses are transmitted directly to humans or if direct human transmission does not occur and spillover via an intermediate host is required. Bats are known to harbor a wide range of viruses including many that are highly pathogenic in humans. This pulse of virus positive bats correlates with an increased incidence of human spillover events [68] . keywords: bats; cells; coronavirus; cov; human; mers; sars; species; studies; study; syndrome; virus; viruses cache: cord-295433-olmein3q.txt plain text: cord-295433-olmein3q.txt item: #224 of 515 id: cord-295559-yc8q62z8 author: Qian, Zhaohui title: Role of the Spike Glycoprotein of Human Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Virus Entry and Syncytia Formation date: 2013-10-03 words: 7314 flesch: 44 summary: We have used lentivirus pseudotypes with MERS-CoV spike glycoprotein to identify cells susceptible to infection with MERS-CoV and to study the role of MERS S protein in virus entry and syncytia formation. Thus, MERS S protein does not require acidification to mediate virus entry, and the acidification required for endosomal entry keywords: cells; coronavirus; cov; entry; figure; human; membrane; mers; protein; pseudovirions; receptor; spike; vero cache: cord-295559-yc8q62z8.txt plain text: cord-295559-yc8q62z8.txt item: #225 of 515 id: cord-295633-vkjcheaz author: Hao, Xin‐yan title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device date: 2019-10-30 words: 5112 flesch: 41 summary: Vector Borne Zoonotic Dis Intranasal influenza infection of mice and methods to evaluate progression and outcome Comparison of traditional intranasal and aerosol inhalation inoculation of mice with influenza A viruses A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Mouseadapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Distribution of aerosols in mouse lobes by fluorescent imaging Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with middle east respiratory syndrome-coronavirus An acute immune response to Middle East respiratory syndrome coronavirus replication contributes to viral pathogenicity Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis SARS and other coronaviruses as causes of pneumonia Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Association between severity of MERS-CoV infection and incubation period Clinical implication of radiographic scores in acute Middle East respiratory syndrome coronavirus pneumonia: report from a single tertiary-referral center of South Korea Mortality rate of ICU patients with the Middle East respiratory syndrome -coronavirus infection at King Fahad Hospital Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 A human DPP4-Knockin mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV One Health Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC A rapid scoping review of Middle East respiratory syndrome coronavirus in animal hosts Clinical and biological character in mouse models for Middle East respiratory syndrome generated by transduction with different doses of DPP4 molecule Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to Middle East respiratory syndrome coronavirus infection and disease Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with Middle East respiratory syndrome coronavirus Emergencies preparedness, response. keywords: aerosol; coronavirus; cov; days; east; group; instillation; mers; mice; middle; syndrome cache: cord-295633-vkjcheaz.txt plain text: cord-295633-vkjcheaz.txt item: #226 of 515 id: cord-295846-quhnesbr author: Li, Huan title: Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis date: 2020-05-05 words: 2791 flesch: 42 summary: Corticosteroid use was associated with delayed virus clearing with a mean difference (MD) = 3.78 days (95% confidence Interval [CI] = 1.16, 6.41 days; I(2) In conclusion, corticosteroid use in subjects with SARS-CoV-2, SARS-CoV, and MERS-CoV infections delayed virus clearing and did not convincingly improve survival, reduce hospitalization duration or ICU admission rate and/or use of mechanical ventilation. keywords: corticosteroid; cov; mers; sars; studies; use cache: cord-295846-quhnesbr.txt plain text: cord-295846-quhnesbr.txt item: #227 of 515 id: cord-295971-jtv1jj2z author: Cho, Sun Young title: MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study date: 2016-07-09 words: 4639 flesch: 52 summary: The emergency room has its own radiology suite for emergency room patients only. Patients' demographic information, underlying disease, dates of emergency room visit, duration of stay with exact arrival and departure times, and location within the emergency room were collected. keywords: care; cov; emergency; group; infection; mers; patient; room; zone cache: cord-295971-jtv1jj2z.txt plain text: cord-295971-jtv1jj2z.txt item: #228 of 515 id: cord-296026-6qtip2ga author: Cho, Sung-il title: Urgent Call for Research on Middle East Respiratory Syndrome (MERS) in Korea date: 2015-07-31 words: 379 flesch: 48 summary: However, it took several weeks to catch up with the spread, because of the initial delays in identifying infective cases. Overall, 16 693 persons have been cumulatively quarantined because of potential contact with infective cases. keywords: cases cache: cord-296026-6qtip2ga.txt plain text: cord-296026-6qtip2ga.txt item: #229 of 515 id: cord-296237-i9cti2ok author: Díez, José-María title: Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins date: 2020-06-19 words: 3746 flesch: 41 summary: The life cycle of SARS coronavirus in Vero E6 cells Crossneutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals Lack of crossneutralization by SARS patient sera towards SARS-CoV-2 Protective antiviral antibodies that lack neutralizing activity: precedents and evolution of concepts COVID-19: consider cytokine storm syndromes and immunosuppression High-dose intravenous immunoglobulin as a therapeutic option for deteriorating patients with Coronavirus Disease Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19 The Efficacy of Intravenous Immunoglobulin Therapy for Severe 2019-nCoV Infected Pneumonia Jordi Bozzo PhD, CMPP and Michael K. James PhD (Grifols) are acknowledged for medical writing and editorial support in the preparation of this manuscript. An Outbreak of Human Coronavirus OC43 Infection and Serological Cross-reactivity with SARS Coronavirus Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests Antigenic crossreactivity between severe acute respiratory syndromeassociated coronavirus and human coronaviruses 229E and OC43 Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis Search for SARS-CoV-2 inhibitors in currently approved drugs to tackle COVID-19 pandemia Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by SARS coronavirus and human coronavirus 229E keywords: antibodies; coronavirus; cov; cov-2; cross; human; ivig; mers; neutralization; sars cache: cord-296237-i9cti2ok.txt plain text: cord-296237-i9cti2ok.txt item: #230 of 515 id: cord-296517-414grqif author: Wong, Gary title: MERS, SARS, and Ebola: The Role of Super-Spreaders in Infectious Disease date: 2015-10-14 words: 2882 flesch: 44 summary: A number of recent virus outbreaks have resulted in rapid virus spread, placing demands on the affected health infrastructures and sparking global concern. Emergence of Zaire Ebola virus disease in Guinea Progress in global surveillance and response capacity 10 years after severe acute respiratory syndrome Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Infection with MERS-CoV causes lethal pneumonia in the common marmoset Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak Outbreak of tuberculosis among regular patrons of a neighborhood bar Cynomolgus macaque as an animal model for severe acute respiratory syndrome Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Explosive school-based measles outbreak: intense exposure may have resulted in high risk, even among revaccinees MERS-COV (97): South Korea, Saudi Arabia. keywords: cases; cov; ebov; mers; outbreak; super; virus cache: cord-296517-414grqif.txt plain text: cord-296517-414grqif.txt item: #231 of 515 id: cord-297062-dmiplvt2 author: Almekhlafi, Ghaleb A. title: Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients date: 2016-05-07 words: 4410 flesch: 45 summary: Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Acute management and long-term survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS APACHE II: a severity of disease classification system The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Interestingly, Acinetobacter baumannii, which is an emerging fatal infection in ICU patients worldwide, was isolated from deep tracheal aspirates in one in four patients. keywords: admission; coronavirus; cov; east; icu; infection; mers; middle; patients; syndrome cache: cord-297062-dmiplvt2.txt plain text: cord-297062-dmiplvt2.txt item: #232 of 515 id: cord-297418-36j840wm author: Carneiro Leão, Jair title: Coronaviridae ‐ old friends, new enemy! date: 2020-05-31 words: 3983 flesch: 42 summary: There is still no consensus on a taxonomic position for SARS-CoV-2, but it belongs to a species related to acute respiratory viruses, based on genetic characteristics, but it is a virus independent of SARS-CoV (Gorbalenya et al., 2020) All rights reserved Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, selflimiting infection that allows recombination events Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins The Epidemiology of Severe Acute Respiratory Syndrome in the 2003 Hong Kong Epidemic: An Analysis of All 1755 Patients Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Structure, Function, and Evolution of Coronavirus Spike Proteins Infectious Bronchitis Virus Variants: keywords: acute; article; copyright; coronavirus; cov; et al; human; mers; sars; syndrome cache: cord-297418-36j840wm.txt plain text: cord-297418-36j840wm.txt item: #233 of 515 id: cord-297652-ut6e1ysz author: Vanden Eynde, Jean Jacques title: COVID-19: A Brief Overview of the Discovery Clinical Trial date: 2020-04-10 words: 3148 flesch: 53 summary: Available online Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Treatment with Lopinavir/Ritonavir or Interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option Systematic review of treatment effects COVID-19-The search for effective therapy A trial of Lopinavir-Ritonavir in adults hospitalized with severe Covid-19 Why re-purposing HIV drugs Lopinavir/ritonavir to inhibit the SARS-Cov2 protease probably won't work-but re-purposing Ribavirin might since it has a very similar binding site within the RNA-polymerase Pharmacy Checker Helping People Safely Find More Affordable Medicine The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein Interferon-β 1a and SARS coronavirus replication Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Husband and Wife Poison Themselves Trying to Self-medicate with Chloroquine Comparison of hydroxychloroquine and chloroquine use and the development of retinal toxicity Pharmacokinetics of Hydroxychloroquine and its clinical implications in chemoprophylaxis against calaria caused by Plasmodium vivax Chloroquine and beyond: Exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities On March 28, the FDA issued an Emergency Use Authorization for use of hydroxychloroquine and chloroquine for patients who do not have access to the drugs via clinical trials [36] . keywords: chloroquine; cov; covid-19; remdesivir; sars; treatment cache: cord-297652-ut6e1ysz.txt plain text: cord-297652-ut6e1ysz.txt item: #234 of 515 id: cord-297691-w4cdfwv0 author: Nikaeen, Ghazal title: Application of nanomaterials in treatment, anti-infection and detection of coronaviruses date: 2020-05-07 words: 4543 flesch: 33 summary: Recent advances in nanomaterials for gene delivery -a review Nano based drug delivery systems: recent developments and future prospects Gold nanoparticles: emerging paradigm for targeted drug delivery system Quantum dot bioconjugates for ultrasensitive nonisotopic detection Nanosurfaces and nanostructures for artificial orthopedic implants Gold-based hybrid nanomaterials for biosensing and molecular diagnostic applications Nanostructured and nanoscale devices, sensors and detectors Cancer nanotechnology: application of nanotechnology in cancer therapy Nanoscale covalent organic polymers as a biodegradable nanomedicine for chemotherapy-enhanced photodynamic therapy of cancer The laboratory diagnosis of dengue virus infection, a review Fenner's Veterinary Virology Recent discovery and development of inhibitors targeting coronaviruses Summarizes essential information for working on a vaccine for coronaviruses Van Der Hoek L. Identification of new human coronaviruses Coronavirus infections and immune responses Lessons from the past: perspectives on severe acute respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV) World Health Organization. Interestingly, it was shown that this assay did not amplify the DNA or cDNA of the other viruses or even of the classical PEDV strain, leading to the fact that the nano-nest PCR assay can be successfully applied for specific detection of variant PEDV keywords: coronaviruses; cov; detection; infection; mers; nanomaterials; nanoparticles; nps; silver; syndrome; vaccine cache: cord-297691-w4cdfwv0.txt plain text: cord-297691-w4cdfwv0.txt item: #235 of 515 id: cord-297853-peqkcix2 author: Khan, Raymond M. title: Middle East respiratory syndrome coronavirus on inanimate surfaces: A risk for health care transmission date: 2016-11-01 words: 1473 flesch: 43 summary: CDC's early response to a novel viral disease, middle east respiratory syndrome coronavirus (MERS-CoV) Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Comparison of surface sampling methods for virus recovery from fomites Hospital outbreak of Middle East respiratory syndrome coronavirus Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Rapid and effective virucidal activity of povidoneiodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus ankara (MVA) Heat inactivation of the Middle East respiratory syndrome coronavirus 9 Prolonged viral shedding 8, 9 and survival on surfaces for 48 hours 3 make it difficult to ignore contaminated environmental surfaces as a potential etiology of hospital outbreaks. keywords: coronavirus; cov; east; mers; syndrome cache: cord-297853-peqkcix2.txt plain text: cord-297853-peqkcix2.txt item: #236 of 515 id: cord-297954-87w2itin author: Memish, Ziad A. title: Middle East respiratory syndrome coronavirus (MERS-CoV): A cluster analysis with implications for global management of suspected cases date: 2015-07-15 words: 1864 flesch: 57 summary: Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers An update on Middle East respiratory syndrome: 2 years later Middle East respiratory syndrome coronavirus infection control: the missing piece? Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution Travel implications of emerging coronaviruses: SARS and MERS-CoV Middle east respiratory syndrome coronavirus (MERS-CoV) in healthcare setting Family cluster of Middle East respiratory syndrome coronavirus infections epidemiological findings from a retrospective investigation Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Hospital outbreak of Middle East respiratory syndrome coronavirus An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia MERS-CoV outbreak in Jeddahea link to health care facilities Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Middle East respiratory syndrome coronavirus (MERS-CoV)-17th update Middle East respiratory syndrome coronavirus (MERS-CoV): summary and risk assessment of current situation in the Republic of Korea and China Etiology of severe community-acquired pneumonia during Hajjdpart of the MERS-CoV surveillance program Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms The Hajj pilgrimage and surveillance for Middle East respiratory syndrome coronavirus in pilgrims from African countries Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Imported cases of Middle East respiratory syndrome: an update We are grateful to the staff of the Ministry of Health in Al-Madinah area and the staff of the regional laboratory, Kingdom of Saudi Arabia. Travel associated MERS cases were reported from: Turkey, Austria, United Kingdom, Germany, France, Greece, the Netherlands, Tunisia, Algeria, Malaysia, Philippines, China, and the United States of America [17] . keywords: cases; cov; mers; syndrome cache: cord-297954-87w2itin.txt plain text: cord-297954-87w2itin.txt item: #237 of 515 id: cord-298350-pq1dcz3a author: Ryan, Jeffrey R. title: Category C Diseases and Agents date: 2016-03-25 words: 7270 flesch: 55 summary: Specific examples explored in this chapter include Nipah virus, hantavirus, West Nile fever virus, and the coronaviruses that cause severe acute respiratory syndrome and Middle East respiratory syndrome. Blood samples from case patients were sent to the CDC to confirm Nipah virus infection; one was confirmed positive (Luby et al., 2006) . keywords: cases; disease; fever; hantavirus; health; mers; nile; nipah; outbreak; patients; sars; transmission; virus; west; wnv cache: cord-298350-pq1dcz3a.txt plain text: cord-298350-pq1dcz3a.txt item: #238 of 515 id: cord-298535-wmxlu3l1 author: Agnihothram, Sudhakar title: Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses date: 2013-11-18 words: 5046 flesch: 36 summary: We noted similar results in Calu-3 cells ( Figure 1D ), and interestingly, an increased amount of a higher-molecular-weight form of S protein (glycosylated dimer) was noted in MERS Eng 1 in both cell lines. Titers of antibody against S protein were consistent from 3 weeks to 5 weeks after illness onset, after which they remained detectable. keywords: coronavirus; cov; cross; figure; hku; human; mers; proteins; sars cache: cord-298535-wmxlu3l1.txt plain text: cord-298535-wmxlu3l1.txt item: #239 of 515 id: cord-298773-vnmc6nqd author: Pfeiffer, Julie K. title: Is the Debate and “Pause” on Experiments That Alter Pathogens with Pandemic Potential Influencing Future Plans of Graduate Students and Postdoctoral Fellows? date: 2015-01-20 words: 1715 flesch: 46 summary: After learning more about the debate, 5% said that they were more likely to work on influenza, SARS, or MERS virus in the future, 28% said that they were less likely to work on influenza, SARS, or MERS virus in the future, and 51% said that they were equally likely to work on influenza, SARS, or MERS virus in the future. Twenty-eight percent of respondents (33% of virologists [42 trainees]) said that they are less likely to work on influenza, SARS, or MERS virus in the future. keywords: debate; future; pause; research cache: cord-298773-vnmc6nqd.txt plain text: cord-298773-vnmc6nqd.txt item: #240 of 515 id: cord-298941-xf2ukinp author: Al-Abdallat, Mohammad Mousa title: Hospital-Associated Outbreak of Middle East Respiratory Syndrome Coronavirus: A Serologic, Epidemiologic, and Clinical Description date: 2014-05-14 words: 4829 flesch: 38 summary: Sera from the 2 fatal cases (designated outbreak subjects 01 and 12) having positive rRT-PCR tests were also tested by the 3 described serology tests. The recombinant btHKU5.2 nucleocapsid proteinbased ELISA was developed by the CDC to detect the presence of antibodies that cross-react with the HKU5.2 N protein in serum samples from possible MERS cases. keywords: antibodies; cases; coronavirus; cov; mers; outbreak; personnel; respiratory; serum; subjects; syndrome cache: cord-298941-xf2ukinp.txt plain text: cord-298941-xf2ukinp.txt item: #241 of 515 id: cord-298974-69xjc5yq author: Adegboye, Oyelola A. title: Network Analysis of MERS Coronavirus within Households, Communities, and Hospitals to Identify Most Centralized and Super-Spreading in the Arabian Peninsula, 2012 to 2016 date: 2018-05-07 words: 4312 flesch: 45 summary: Reducing contact formation especially within the hospital by restricting hospital visitation for MERS patient families and reducing the number of healthcare workers with access to MERS patients will certainly have significant effect on the spread of MERS disease. There were 1113 isolated cases while the number of recorded contacts per MERS patient is between 1 (n=210) and 17 (n=1), with a mean of 0.27 (SD = 0.76). keywords: cases; centrality; healthcare; hospital; infection; mers; network; nodes; patient cache: cord-298974-69xjc5yq.txt plain text: cord-298974-69xjc5yq.txt item: #242 of 515 id: cord-299519-hfgmmuy6 author: Alenazi, Thamer H. title: Severe Middle East Respiratory Syndrome (MERS) Pneumonia date: 2019-10-26 words: 5553 flesch: 41 summary: Post-mortem autopsies were rarely performed on MERS patients due to cultural reasons in the Arabian Peninsula. A study that compared 330 critically ill MERS-CoV infected patients with 220 critically ill patients with non-MERS severe acute respiratory infection (SARI) found that MERS patients were younger than non-MERS SARI patients (median [Q1, Q3] 58 keywords: cases; coronavirus; cov; east; infection; mers; middle; patients; study; syndrome cache: cord-299519-hfgmmuy6.txt plain text: cord-299519-hfgmmuy6.txt item: #243 of 515 id: cord-299608-wqa98m4v author: Al-Turaiki, Isra title: Building predictive models for MERS-CoV infections using data mining techniques date: 2016-09-15 words: 2380 flesch: 55 summary: Decision tree classification models have many advantages. Tables 1 and 2 summarizes the evaluation measures for the obtained recovery and stability models, respectively. keywords: cov; data; mers; mining; models cache: cord-299608-wqa98m4v.txt plain text: cord-299608-wqa98m4v.txt item: #244 of 515 id: cord-299621-m4kdkmey author: Kumar, A. title: Outbreak of Middle East respiratory syndrome coronavirus, Saudi Arabian experience date: 2017-08-31 words: 1871 flesch: 36 summary: Hospital outbreak of Middle East respiratory syndromecoronavirus Coronavirus: diagnostics epidemiology and transmission None. In addition, portable HEPA filter machines (8) were procured to be used in respiratory illness rooms identified at high risk patient care locations viz: haemodialysis unit, Outpatient services, Special care baby unit, Paediatric services, Obstetric and Internal Medicine wards. keywords: cov; hospital; infection; mers; patients; respiratory cache: cord-299621-m4kdkmey.txt plain text: cord-299621-m4kdkmey.txt item: #245 of 515 id: cord-299720-f0ny4ur5 author: Kim, Seung Woo title: Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea date: 2017-03-01 words: 3916 flesch: 45 summary: Spreaders were defined as confirmed cases of MERS-CoV infection that were epidemiologically suspected of transmitting MERS-CoV to 1 or more persons. [15] , which include persons who stayed in a room or ward with a confirmed case, who directly contacted respiratory secretions from confirmed cases, or who stayed within 2 m from the confirmed cases without wearing appropriate personal protective equipment. keywords: cases; cov; infection; mers; outbreak; spreaders; transmission cache: cord-299720-f0ny4ur5.txt plain text: cord-299720-f0ny4ur5.txt item: #246 of 515 id: cord-299986-wuaxatrb author: Afsar, Nasir Ali title: The looming pandemic of COVID-19: What therapeutic options do we have now? date: 2020-04-21 words: 627 flesch: 29 summary: Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population level observational study Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Case of the index patient who caused tertiary transmission of COVID-19 infection in Korea: the application of lopinavir/ritonavir for the treatment of COVID-19 infected pneumonia monitored by quantitative RT-PCR Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Ribavirin and interferon therapy for critically Ill patients with Middle East respiratory syndrome: a multicenter observational study Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide Corticosteroid therapy for critically Ill patients with Middle East respiratory syndrome Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication This is highly imperative that although new drug and vaccine development is in progress, existing treatment may be applied to save precious lives. keywords: coronavirus; cov; treatment cache: cord-299986-wuaxatrb.txt plain text: cord-299986-wuaxatrb.txt item: #247 of 515 id: cord-300078-svu06v9c author: Haghani, Milad title: Covid-19 pandemic and the unprecedented mobilisation of scholarly efforts prompted by a health crisis: Scientometric comparisons across SARS, MERS and 2019-nCov literature date: 2020-06-01 words: 6373 flesch: 43 summary: Covid-19 studies seem to have been distributed across a broader variety of journals and subject areas. Covid-19 studies also display the involvement of authors from a broader variety of countries compared to SARS and MRS. keywords: cluster; covid-19; items; literature; mers; number; research; sars; studies; terms cache: cord-300078-svu06v9c.txt plain text: cord-300078-svu06v9c.txt item: #248 of 515 id: cord-300950-ag0sql4i author: Lin, John title: Potential therapeutic options for coronavirus disease 2019: using knowledge of past outbreaks to guide future treatment date: 2020-06-05 words: 1916 flesch: 45 summary: Future anti-viral therapies such as remdesivir may provide some much-needed firepower to combat epidemic coronavirus strains like 2019-nCoV. Optimistically, two clinical studies on anti-viral COVID-19 treatment have recently come into fruition: the use of lopinavir/ritonavir in a phase 4, randomized controlled trial (No. NCT04255017); and the use of remdesivir in a phase 3, randomized, double-blind, placebo-controlled study (No. NCT04252664). Initial treatment with lopinavir/ritonavir in SARS patients was associated with lower intubation rate, lower adverse clinical events and mortality compared to ribavirin and corticosteroid. keywords: coronavirus; cov; covid-19; mers; sars cache: cord-300950-ag0sql4i.txt plain text: cord-300950-ag0sql4i.txt item: #249 of 515 id: cord-301016-9t7v7ipt author: Forni, Diego title: The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses date: 2015-09-25 words: 5089 flesch: 40 summary: 1 M1a is a nearly neutral model that assumes one dN/dS (ω ) class between 0 and 1, and one class with ω = 1; M2a (positive selection model) is the same as M1a plus an extra class of ω > 1. ω < 1 is beta distributed among sites; M8 (positive selection model) is the same as M7 but also includes an extra category of sites with ω > 1. 3 2Δ lnL: twice the difference of the natural logs of the maximum likelihood of the models being compared. keywords: coronavirus; cov; fig; fusion; hr1; mers; protein; recombination; selection; site; spike cache: cord-301016-9t7v7ipt.txt plain text: cord-301016-9t7v7ipt.txt item: #250 of 515 id: cord-301103-idu4j78a author: Sohrab, Sayed S. title: Genetic diversity of MERS-CoV spike protein gene in Saudi Arabia date: 2019-12-09 words: 4265 flesch: 48 summary: The phylogenetic analysis with Spike protein gene sequences (Nucleotide and Amino acid) of selected MERS-CoV sequences deposited in GenBank was performed. Although, significant information related to MERS-CoV disease, spread, infection, epidemiology, clinical features have been published, A little information is available on the sequence diversity of Spike protein gene. keywords: camel; cov; gene; human; mers; protein; saudi; sequences; spike cache: cord-301103-idu4j78a.txt plain text: cord-301103-idu4j78a.txt item: #251 of 515 id: cord-301313-9595vm0k author: OKBA, NISREEN M.A. title: SARS-CoV-2 specific antibody responses in COVID-19 patients date: 2020-03-20 words: 4281 flesch: 48 summary: Serum samples from SARS patients (7) were kindly provided by professor Malik Peiris, Hong Kong University. The virus was identified to be a betacoronavirus related to severe acute respiratory syndrome coronavirus (SARS-CoV) and thus, was named SARS-CoV-2 (2) . keywords: antibodies; cov; cov-2; medrxiv; patients; preprint; sars; sera cache: cord-301313-9595vm0k.txt plain text: cord-301313-9595vm0k.txt item: #252 of 515 id: cord-301547-d4wt9dqp author: Seng, J. J. B. title: Pandemic related Health literacy - A Systematic Review of literature in COVID-19, SARS and MERS pandemics date: 2020-05-11 words: 5403 flesch: 40 summary: https://doi.org/10.1101/2020.05.07.20094227 doi: medRxiv preprint For populations at increased risk of poor clinical outcomes of infections such as the elderly, immunocompromised patients, human-immunodeficiency virus or with multiple comorbidities, they form high priority populations where the levels of pandemic health literacy should be assessed. key: cord-301547-d4wt9dqp authors: Seng, J. J. B.; Yeam, C. T.; Huang, W. C.; Tan, N. C.; Low, L. L. title: Pandemic related Health literacy - A Systematic Review of literature in COVID-19, SARS and MERS pandemics date: 2020-05-11 journal: nan DOI: 10.1101/2020.05.07.20094227 sha: doc_id: 301547 cord_uid: d4wt9dqp Background: Health literacy plays an essential role in ones ability to acquire and understand critical medical information in the COVID-19 infodemic and other pandemics. keywords: covid-19; health; health literacy; knowledge; license; literacy; pandemic; preprint; studies; study cache: cord-301547-d4wt9dqp.txt plain text: cord-301547-d4wt9dqp.txt item: #253 of 515 id: cord-301633-t8s4s0wo author: Gralinski, Lisa E. title: Return of the Coronavirus: 2019-nCoV date: 2020-01-24 words: 4001 flesch: 47 summary: Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2 Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV Viruses and Koch's Postulates A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques 15 Medical Staff in Wuhan Confirmed New Coronavirus Pneumonia, and Another Suspected Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review The Role of Super-Spreaders in Infectious Disease Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus No Snakes Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence SARS-like WIV1-CoV poised for human emergence Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria Evidence for camel-to-human transmission of MERS coronavirus Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study Risk Factors for Fatal Middle East Respiratory Syndrome Coronavirus Infections in Saudi Arabia: Analysis of the WHO Line List Severe Acute Respiratory Syndrome Preliminary Phylogenetic Analysis of 11 nCoV2019 Genomes Genomic Epidemiology of Novel Coronavirus (nCoV) Using Data Generated by Fudan University, China CDC, Chinese Academy of Medical Sciences, Chinese Academy of Sciences and the Thai National Institute of Health Shared via GISAID Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin Jumping species-a mechanism for coronavirus persistence and survival keywords: 2019; cases; coronavirus; cov; health; human; mers; ncov; sars cache: cord-301633-t8s4s0wo.txt plain text: cord-301633-t8s4s0wo.txt item: #254 of 515 id: cord-301730-flv5lnv8 author: Pandey, Anamika title: Natural Plant Products: A Less Focused Aspect for the COVID-19 Viral Outbreak date: 2020-10-15 words: 7111 flesch: 35 summary: Afterward, continuous efforts have been made to screen different plant sources via in silico, in vitro, and in vivo assays for anti-viral activity towards several viruses such as parainfluenza virus type 3, respiratory syncytial virus, poliovirus type 1, herpes simplex virus (HSV), enteric coronavirus, and rotavirus (RV). Few compounds such as dihydrotanshinone isolated from the root of Salvia miltiorrhiza showed anti-viral activity against both SARS and MERS CoV by the inhibition of proteases and hindering of the viral entry, respectively (Park et al., 2012; Kim et al., 2018) . keywords: activity; anti; coronavirus; cov; cov-2; covid-19; drugs; et al; inhibitors; mers; plant; potential; protease; sars; trials cache: cord-301730-flv5lnv8.txt plain text: cord-301730-flv5lnv8.txt item: #255 of 515 id: cord-302983-3v5bc80z author: Matterne, Uwe title: Health literacy in the general population in the context of epidemic or pandemic coronavirus outbreak situations: Rapid scoping review date: 2020-10-10 words: 5447 flesch: 40 summary: In other words, what is necessary beyond governmental regulations and policy, is an increase in the levels of COVID-19 related health literacy [12, 13] . There is substantial overlap between socio-cognitive predictors of health behaviour and HL. keywords: coronavirus; health; knowledge; literacy; outbreak; pandemic; sars; studies; study; syndrome cache: cord-302983-3v5bc80z.txt plain text: cord-302983-3v5bc80z.txt item: #256 of 515 id: cord-303272-1w8epdht author: Reusken, Chantal BEM title: Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study date: 2013-08-09 words: 4493 flesch: 49 summary: Cattle (n=80), sheep (n=40), goats (n=40), dromedary camels (n=155), and various other camelid species (n=34) were tested for specific serum IgG by protein microarray using the receptor-binding S1 subunits of spike proteins of MERS-CoV, severe acute respiratory syndrome coronavirus, and human coronavirus OC43. The receptor-binding domains, which contain the S1 subunit of spike proteins of MERS-CoV (residues 1-747), SARS-CoV (residues 1-676), and human coronavirus OC43 (residues 1-760) were expressed, purifi ed, and spotted on glass slides. keywords: antibodies; antigen; bovine; camels; coronavirus; cov; east; human; mers; middle; oc43; sera cache: cord-303272-1w8epdht.txt plain text: cord-303272-1w8epdht.txt item: #257 of 515 id: cord-303289-qoukiqr7 author: Hemida, M. G. title: Coronavirus infections in horses in Saudi Arabia and Oman date: 2017-03-13 words: 2821 flesch: 44 summary: Presence of antibodies but no evidence for circulation of MERS-CoV in dromedaries on the Canary Islands Characterization of a coronavirus isolated from a diarrheic foal Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Development of an equine coronavirus-specific enzyme-linked immunosorbent assay to determine serologic responses in naturally infected horses Human infection with MERS coronavirus after exposure to infected camels Serologic assessment of possibility for MERS-CoV infection in equids Absence of middle east respiratory syndrome coronavirus in camelids First detection of equine coronavirus (ECoV) in Europe Epidemic of equine coronavirus at Obihiro Racecourse, Hokkaido, Japan in 2012 Kinetics of serologic responses to MERS coronavirus infection in humans Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Prevalence of equine coronavirus in nasal secretions from horses with fever and upper respiratory tract infection Geographic distribution of MERS coronavirus among dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) Isolation and characterization of dromedary camel coronavirus UAE-HKU23 from dromedaries of the middle east: Minimal serological cross-reactivity between MERS coronavirus and dromedary camel coronavirus UAE-HKU23 Novel betacoronavirus in dromedaries of the Middle East SUPPORTING INFORMATION There were twenty-four sera with undetectable antibody to BCoV with detectable ECoV antibody titres ranging from 20 to 640. keywords: bcov; coronavirus; ecov; hku23; horses; mers cache: cord-303289-qoukiqr7.txt plain text: cord-303289-qoukiqr7.txt item: #258 of 515 id: cord-303670-fma8wq4z author: LIU, Ren-qiang title: Newcastle disease virus-based MERS-CoV candidate vaccine elicits high-level and lasting neutralizing antibodies in Bactrian camels date: 2017-10-31 words: 4235 flesch: 46 summary: In the present study, we determined that immunization with rLa-MERS-S induced a slightly higher level of IgG1 than IgG2a antibodies against S protein of MERS-CoV. Vaccine Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs Rift Valley fever virus immunity provided by a paramyxovirus vaccine vector The NS1 gene contributes to the virulence of H5N1 avian influenza viruses Absence of Middle East respiratory syndrome coronavirus in Bactrian camels in the West Inner Mongolia Autonomous Region of China: Surveillance study results from Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector Human infection with MERS coronavirus after exposure to infected camels Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furinmediated activation of the spike protein keywords: antibodies; cells; cov; mers; mice; ndv; protein; rla; virus cache: cord-303670-fma8wq4z.txt plain text: cord-303670-fma8wq4z.txt item: #259 of 515 id: cord-303786-snch80z7 author: Kim, Hyun-Chung title: Psychiatric Findings in Suspected and Confirmed Middle East Respiratory Syndrome Patients Quarantined in Hospital: A Retrospective Chart Analysis date: 2018-03-30 words: 2670 flesch: 49 summary: Suspected MERS patients did not exhibit psychiatric symptoms or receive a psychiatric diagnosis. Of the 34 surviving confirmed or suspected MERS patients, 12 (35.3%) were male and 22 (64.7%) were female and had a mean age of 46.15±20.41 (range, 21-86) years. keywords: depression; disorders; health; mers; patients; symptoms cache: cord-303786-snch80z7.txt plain text: cord-303786-snch80z7.txt item: #260 of 515 id: cord-303915-14yfs4pa author: Almazán, Fernando title: Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate date: 2013-09-10 words: 7147 flesch: 42 summary: A live attenuated SARS coronavirus is immunogenic and efficacious in golden Syrian hamsters Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease Coronaviruses maintain viability despite dramatic rearrangements of the strictly conserved genome organization Vaccines to prevent severe acute respiratory syndrome coronavirusinduced disease Complete nucleotide sequence of two generations of a bacterial artificial chromosome cloning vector Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) In contrast, rMERS-CoV-⌬E was rescued in E ϩ cells with titers of around 1 ϫ 10 3 TCID 50 /ml but not in control E Ϫ cells, in which the virus was not detectable from passage 1 (limit of detection, 50 TCID 50 /ml) keywords: cdna; cells; clone; coronavirus; cov; gene; infectious; mers; pbac; protein; respiratory; virus; viruses cache: cord-303915-14yfs4pa.txt plain text: cord-303915-14yfs4pa.txt item: #261 of 515 id: cord-303917-2tu707ng author: Zhang, Lei title: Potential interventions for novel coronavirus in China: A systematic review date: 2020-03-03 words: 5438 flesch: 36 summary: The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus Nutrients and their role in host resistance to infection Vitamin C intake and susceptibility to pneumonia Vitamin D insufficiency among free-living healthy young adults Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves Vitamin E metabolic effects and genetic variants: a challenge for precision nutrition in obesity and associated disturbances Vitamin E deficiency intensifies the myocardial injury of coxsackievirus B3 infection of mice Increased virulence of coxsackievirus B3 in mice due to vitamin E or selenium deficiency Macrophage-derived extracellular vesicles induce long-lasting immunity against hepatitis C virus which is blunted by polyunsaturated fatty acids Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza Anti-HCV activities of selective polyunsaturated fatty acids Selenium and human health Micronutrients and host resistance to viral infection Review: micronutrient selenium deficiency influences evolution of some viral infectious diseases Selenium deficiency increases the pathology of an influenza virus infection Rapid genomic evolution of a non-virulent coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates Combined adjuvant effect of ginseng stem-leaf saponins and selenium on immune responses to a live bivalent vaccine of Newcastle disease virus and infectious bronchitis virus in chickens Zinc and immunity: an essential interrelation Zinc deficiency Zinc supplementation for the treatment of measles in children Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture Crossing the iron gate: why and how transferrin receptors mediate viral entry Childhood iron deficiency anemia leads to recurrent respiratory tract infections and gastroenteritis Chicken interferon type I inhibits infectious bronchitis virus replication and associated respiratory illness Prevention of experimental coronavirus colds with intranasal alpha-2b interferon Ribavirin and interferon-beta synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Proposal for vaccination against SARS coronavirus using avian infectious bronchitis virus strain H from The Netherlands Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): a review Uses of intravenous gammaglobulin in immune hematologic disease Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome Strokes, thromboembolic events, and IVIg: rare incidents blemish an excellent safety record Thymosin alpha 1 and HIV-1: recent advances and future perspectives A reappraisal of thymosin alpha1 in cancer therapy Serum thymosin alpha 1 levels in normal and pathological conditions Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways Clinical investigation of outbreak of nosocomial severe acute respiratory syndrome Anti-SARS coronavirus agents: a patent review (2008-present) Modulation of immune response in aged humans through different administration modes of thymopentin Phase variation in the modulation of the human immune response Thymopentin as adjuvant in non-responders or hyporesponders to hepatitis B vaccination The general immunopharmacology of levamisole Lymphocyte subsets in measles. Depressed helper/inducer subpopulation reversed by in vitro treatment with levamisole and ascorbic acid Systemic cyclosporine and corneal transplantation Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A Factor in virus replication and potential target for anti-viral therapy The SARS-coronavirus-host interactome: identification of cyclophilins as target for pancoronavirus inhibitors Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro Flavonoids: an overview Flavonoids from pterogyne nitens inhibit hepatitis C virus entry Inhibition of SARS-CoV 3CL protease by flavonoids Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition Angiotensin-converting enzyme-2: a molecular and cellular perspective Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus The secret life of ACE2 as a receptor for the SARS virus Characterization of severe acute respiratory syndromeassociated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry Severe acute respiratory syndrome coronavirus entry into host cells: Opportunities for therapeutic intervention Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Effects of chloroquine on viral infections: an old drug against today's diseases? Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction Old drugs as lead compounds for a new disease? keywords: acute; addition; coronavirus; cov; covid-19; human; immune; infection; patients; replication; sars; syndrome; treatment; vitamin cache: cord-303917-2tu707ng.txt plain text: cord-303917-2tu707ng.txt item: #262 of 515 id: cord-303941-3lg1bzsi author: Han, Hui-Ju title: Bats as reservoirs of severe emerging infectious diseases date: 2015-07-02 words: 4680 flesch: 46 summary: Metagenomic analysis of the viromes of three North American bat species: viral diversity among different bat species that share a common habitat Transmission of Ebola hemorrhagic fever: a study of risk factors in family members Bats host major mammalian paramyxoviruses Amplification of emerging viruses in a bat colony Ecology of Bat Migration Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in China Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Host and viral ecology determine bat rabies seasonality and maintenance Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus Virome profiling of bats from Myanmar by metagenomic analysis of tissue samples reveals more novel Mammalian viruses Close relative of human Middle East respiratory syndrome coronavirus in bat Early eocene bat from wyoming Isolation and partial characterisation of a new virus causing acute haemorrhagic fever in Zaire Bats, clocks, and rocks: diversification patterns in Chiroptera Ebola virus disease in health care workers -sierra leone Nipah virus encephalitis outbreak in Malaysia Severe acute respiratory syndrome coronaviruslike virus in Chinese horseshoe bats Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo Fruit bats as reservoirs of Ebola virus Bats are natural reservoirs of SARS-like coronaviruses SARS, wildlife, and human health Recurrent zoonotic transmission of Nipah virus into humans Human infection with MERS coronavirus after exposure to infected camels Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines A morbillivirus that caused fatal disease in horses and humans Outbreak of Nipah-virus infection among abattoir workers in Singapore Rabies in the vampire bat of Trinidad, with special reference to the clinical course and the latency of infection The transmission of paralytic rabies in Trinidad by the vampire bat (Desmodus rotundus murinus Wagner Ecological dynamics of emerging bat virus spillover Bats are a major natural reservoir for hepaciviruses and pegiviruses Characterization of Nipah virus from naturally infected Pteropus vampyrus bats Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin Ebola haemorrhagic fever in Zaire Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Mammal Species of the World: A Taxonomic and Geographic Reference, 3 vols Virus infections in bats Marburg Hemorrhagic Fever-The Netherlands ex Uganda Correlates of viral richness in bats (order Chiroptera) Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Now arriving, the deadly Ebola virus lands in America Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 Negative findings from serological studies of equine morbillivirus in the Queensland horse population Novel Henipa-like virus, Mojiang Paramyxovirus, in rats MERS-related betacoronavirus in Vespertilio superans bats Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia Serologic evidence for the presence in Pteropus bats of a paramyxovirus related to equine morbillivirus Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia The huge diversity of bat species can provide a large breeding ground for viruses. keywords: bats; cov; ebola; et al; humans; mers; sars; transmission; viruses cache: cord-303941-3lg1bzsi.txt plain text: cord-303941-3lg1bzsi.txt item: #263 of 515 id: cord-304030-6ve5plea author: Aboagye, James Odame title: Overexpression of the nucleocapsid protein of Middle East respiratory syndrome coronavirus up-regulates CXCL10 date: 2018-10-17 words: 3727 flesch: 48 summary: In order to determine if the nucleocapsid protein of MERS-CoV (MERS-N) plays a role in viral–host interactions, a murine monoclonal antibody was generated so as to allow detection of the protein in infected cells as well as in overexpression system. With the aim to generate an antibody that can be used to detect the expression of MERS-N protein in infected cells or transfected cells, a fragment corresponding to residues 196-413 in N was successfully expressed and purified from E. coli (data not shown). keywords: cells; coronavirus; cov; cxcl10; figure; mab; mers; protein cache: cord-304030-6ve5plea.txt plain text: cord-304030-6ve5plea.txt item: #264 of 515 id: cord-304054-sn7rswab author: Khan, Gulfaraz title: Chapter 8 The Middle East Respiratory Syndrome Coronavirus: An Emerging Virus of Global Threat date: 2020-12-31 words: 4276 flesch: 40 summary: respiratory syndrome coronavirus Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Middle East respiratory syndrome coronavirus infection during pregnancy: a report of 5 cases from Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Emerging and reemerging diseases in the World Health Organization (WHO) Eastern Mediterranean Region-progress, challenges, and WHO initiatives MERS-CoV: understanding the latest human coronavirus threat Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study SARS and MERS: recent insights into emerging coronaviruses Transmission of MERS-coronavirus in household contacts Vaccines for the prevention against the threat of MERS-CoV Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Molecular evolution of human coronavirus genomes The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Outbreak of Middle East respiratory syndrome at Tertiary Care Hospital Transmission of Middle East Respiratory syndrome coronavirus infections in healthcare settings A novel coronavirus capable of lethal human infections: an emerging picture Middle East respiratory syndrome infection control and prevention guideline for healthcare facilities Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Transmission routes of respiratory viruses among humans Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo MERS coronavirus: diagnostics, epidemiology and transmission Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Jumping species-a mechanism for coronavirus persistence and survival Dipeptidyl peptidase 4 distribution in the human respiratory tract Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015 Asymptomatic MERS-CoV infection in humans possibly linked to infected dromedaries imported from Oman to United Arab Emirates Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia Middle East respiratory syndrome coronavirus disease is rare in children: an update from Saudi Arabia Occurrence of the Middle East respiratory syndrome coronavirus (MERS-CoV) across the gulf corporation council countries: four years update Further evidence for bats as the evolutionary source of Middle East keywords: coronavirus; cov; east; et al; infection; mers; middle; respiratory cache: cord-304054-sn7rswab.txt plain text: cord-304054-sn7rswab.txt item: #265 of 515 id: cord-304057-d2r92nji author: Harrath, Rafik title: Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia date: 2018-04-26 words: 1488 flesch: 43 summary: These results may provide evidence that MERS‐CoV has previously infected dromedary camels in Tabuk and may support the possible role of camels in the human infection. key: cord-304057-d2r92nji authors: Harrath, Rafik; Abu Duhier, Faisel M. title: Sero‐prevalence of Middle East respiratory syndrome coronavirus (MERS‐CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia date: 2018-04-26 journal: J Med Virol DOI: 10.1002/jmv.25186 sha: doc_id: 304057 cord_uid: d2r92nji The Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. keywords: antibodies; camels; cov; mers cache: cord-304057-d2r92nji.txt plain text: cord-304057-d2r92nji.txt item: #266 of 515 id: cord-304227-rbr2un1u author: None title: Updated Information on the Epidemiology of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection and Guidance for the Public, Clinicians, and Public Health Authorities, 2012–2013 date: 2013-09-27 words: 2043 flesch: 41 summary: WHO statement on the second meeting of the IHR Emergency Committee concerning MERS-CoV Close relative of human Middle East respiratory syndrome coronavirus in bat Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Seroepidemiology for MERS coronavirus using micronuetralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Prevalence of diabetes mellitus in a Saudi community First cases of Middle East Respiratory syndrome coronavirus (MERS-CoV) infections in France, investigations and implications for the prevention of human-to-human transmission This guidance might change as CDC learns more about the epidemiology of MERS-CoV. CDC will continue to post the most current information and guidance on its MERS-CoV website. keywords: cov; health; infection; mers cache: cord-304227-rbr2un1u.txt plain text: cord-304227-rbr2un1u.txt item: #267 of 515 id: cord-304271-vyayyk50 author: Qin, Yuan-Yuan title: Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019: protocol of a randomized controlled trial date: 2020-03-05 words: 3999 flesch: 31 summary: [2] However, other coronaviruses, such as those associated with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), may cause severe respiratory disease, and have caused a total of more than 10,000 laboratory-confirmed cases globally in the past two decades, with a 10% and 34.4% case-fatality rate, respectively. Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 6) 2020 The Third International Consensus definitions for sepsis and septic shock (Sepsis-3) Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong Development of a standard treatment protocol for severe acute respiratory syndrome High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome A major outbreak of severe acute respiratory syndrome in Hong Kong A cluster of cases of severe acute respiratory syndrome in Hong Kong keywords: acute; coronavirus; glucocorticoid; patients; sars; study; syndrome; therapy; treatment cache: cord-304271-vyayyk50.txt plain text: cord-304271-vyayyk50.txt item: #268 of 515 id: cord-304943-thg4fqi2 author: Noor, Aziz Ullah title: Epidemiology of CoViD-19 Pandemic: Recovery and mortality ratio around the globe date: 2020-05-17 words: 3251 flesch: 51 summary: In this context, the identification of source animals, responsible for the transmission of CoViD-19 virus is extremely essential in order to control and prevent any future outbreak. Yet another reason of this pandemic was as 80% of CoViD-19 cases are mild or asymptomatic so the symptom base control of this disease is very difficult and less effective. keywords: 2019; cases; coronavirus; covid-19; infection; mers; novel; sars cache: cord-304943-thg4fqi2.txt plain text: cord-304943-thg4fqi2.txt item: #269 of 515 id: cord-305134-s7h6bpof author: Mackman, Nigel title: Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses date: 2020-07-13 words: 6427 flesch: 35 summary: Pulmonary thrombosis and microvascular thrombosis are observed in autopsy studies, and this may contribute to the severe hypoxia observed in COVID-19 patients. It is likely that multiple systems contribute to thrombosis in COVID-19 patients, such as activation of coagulation, platelet activation, hypofibrinolysis, endothelial cell dysfunction, inflammation, neutrophil extracellular traps, and complement. keywords: activation; acute; cells; coagulation; coronavirus; covid-19; infection; lung; patients; sars; study; syndrome; thrombosis cache: cord-305134-s7h6bpof.txt plain text: cord-305134-s7h6bpof.txt item: #270 of 515 id: cord-305175-1wg0wodr author: Dolzhikova, I. V. title: Preclinical Studies of Immunogenity, Protectivity, and Safety of the Combined Vector Vaccine for Prevention of the Middle East Respiratory Syndrome date: 2020 words: 4501 flesch: 42 summary: To date, several candidate vaccine preparations based on a protective antigen, MERS-CoV S glycoprotein and its derivatives (S1 subunit, receptor-binding domain), are known: vector vaccines (based on recombinant adenoviruses and vaccinia virus), a DNA vaccine based on plasmid DNA, as well as vaccines based on recombinant proteins and virus-like particles [8] [9] [10] [11] [12] Since the formation of a humoral and cellular immune response is important to protect against MERS-CoV, the use of recombinant viral vectors for antigen delivery seems promising for the development of anti-MERS vaccines. keywords: animals; cov; glycoprotein; immune; immunization; mers; mice; vaccination; vaccine; virus cache: cord-305175-1wg0wodr.txt plain text: cord-305175-1wg0wodr.txt item: #271 of 515 id: cord-305317-08a1oin2 author: Maltezou, Helena C. title: Middle East respiratory syndrome coronavirus: Implications for health care facilities date: 2014-12-31 words: 3647 flesch: 46 summary: Ninth update Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Middle East respiratory syndrome coronavirus infections in health care workers First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital-associated outbreak of Middle East Respiratory Syndrome coronavirus: a serologic, epidemiologic, and clinical description A case of imported Middle East respiratory syndrome coronavirus infection and public health response Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Prediction of intrinsic disorder in MERS-CoV/ HCoV-EMC supports a high oral-fecal transmission Severe respiratory illness caused by a novel coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Contact investigation of a case of human novel coronavirus infection treated in a German hospital Current advancements and potential strategies in the development of MERS-CoV vaccines Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV) Preventing the spread of influenza A H1N1 2009 to health-care workers Illinois resident who had contact with Indiana MERS patient tests positive for MERS coronavirus Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus (MERS-CoV) e update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature updateeas of 9 Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia European Centre for Disease Prevention and Control. keywords: coronavirus; cov; east; health; infection; mers; syndrome cache: cord-305317-08a1oin2.txt plain text: cord-305317-08a1oin2.txt item: #272 of 515 id: cord-305422-t8azymo7 author: Yi, Ye title: COVID-19: what has been learned and to be learned about the novel coronavirus disease date: 2020-03-15 words: 8317 flesch: 47 summary: In SARS patients, it has been demonstrated that fever (99%-100%), dry cough (29%-75%), dyspnea (40%-42%), diarrhea (20-25%), and sore throat (13-25%) were the major symptoms and ventilation support was required for approximately 14%-20% of the patients [45] . Cardiac events were also the main reason for death in SARS patients [55, 65, 99] . keywords: acute; cases; china; coronavirus; cov-2; covid-19; disease; human; infection; mers; novel; outbreak; patients; sars; study; syndrome; treatment cache: cord-305422-t8azymo7.txt plain text: cord-305422-t8azymo7.txt item: #273 of 515 id: cord-305534-936peb1n author: Johnson, Kemmian D. title: Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19 date: 2020-08-13 words: 6730 flesch: 34 summary: The main reason for the development of these symptoms is the presence of severe pneumonia in COVID-19 patients. However, the pulmonary symptoms can vary in COVID-19 patients, possibly due to variation in severity of disease at the time of presentation. keywords: acute; coronavirus; cov-2; covid-19; disease; injury; manifestations; patients; sars; study; syndrome cache: cord-305534-936peb1n.txt plain text: cord-305534-936peb1n.txt item: #274 of 515 id: cord-305582-3hmsknon author: Li, Lei title: Therapeutic strategies for critically ill patients with COVID-19 date: 2020-04-20 words: 6194 flesch: 35 summary: Available drug options that come from the clinical experience of treating SARS, MERS and other previous influenza virus have been used for the treatment of COVID-19 patients. Considering the high incidence of bacterial infection for critically ill patients with COVID-19, it is essential to test the kinetics of procalcitonin (PCT) and C-reaction protein (CRP) in COVID-19 patients for timely diagnosis and intervention of bacterial infection. keywords: 2019; acute; antiviral; coronavirus; covid-19; infection; influenza; ncov; patients; sars; syndrome; therapy; treatment; ventilation cache: cord-305582-3hmsknon.txt plain text: cord-305582-3hmsknon.txt item: #275 of 515 id: cord-305745-9lngdjow author: Solnier, Julia title: Flavonoids: A complementary approach to conventional therapy of COVID-19? date: 2020-09-18 words: 9550 flesch: 32 summary: In docking studies, Jo et al. showed that the additional 8-hydroxyl group of herbacetin seems to be crucial for its high binding affinity to the polar S1 site and the hydrophobic S2 site of SARS-CoV 3CLpro In a following docking study, Jo et al. showed that a rhamnose substitution instead of glucose (in quercetin 3-b-glucoside), results in a stronger binding with MERS-CoV 3CLpro (Jo et al. 2019) . keywords: activity; antiviral; compounds; coronavirus; cov; cov-2; et al; flavonoids; inhibition; inhibitors; mers; plpro; proteases; quercetin; sars; studies; table cache: cord-305745-9lngdjow.txt plain text: cord-305745-9lngdjow.txt item: #276 of 515 id: cord-305773-ikm1famj author: Lan, Bowen title: Clinical imaging research of the first Middle East respiratory syndrome in China date: 2015-11-23 words: 1633 flesch: 53 summary: Based on the first case of Middle East respiratory syndrome found in China, a clinical research in combination with radiological findings was studied. Middle East respiratory syndrome (MERS), also known as camel flu, is a viral respiratory illness caused by a novel human beta-coronavirus (CoV) keywords: june; mers; middle; syndrome cache: cord-305773-ikm1famj.txt plain text: cord-305773-ikm1famj.txt item: #277 of 515 id: cord-305871-w1quh4fx author: Hindawi, Salwa I. title: Inactivation of Middle East respiratory syndrome‐coronavirus in human plasma using amotosalen and ultraviolet A light date: 2017-12-14 words: 4527 flesch: 41 summary: Although the potential for MERS‐CoV transmission through blood transfusion is not clear, MERS‐CoV was recognized as a pathogen of concern for the safety of the blood supply especially after its detection in whole blood, serum, and plasma of infected individuals. Currently, there are more than 70 known pathogens that have been recognized by the AABB as pathogens of concern for blood transfusion; 25 however, blood donations are only screened for a small number of pathogens on a regular basis. keywords: blood; coronavirus; cov; inactivation; mers; middle; plasma; rna; samples; syndrome; transfusion cache: cord-305871-w1quh4fx.txt plain text: cord-305871-w1quh4fx.txt item: #278 of 515 id: cord-306004-amv0los1 author: Widagdo, W. title: Host Determinants of MERS-CoV Transmission and Pathogenesis date: 2019-03-19 words: 4537 flesch: 42 summary: An epidemiological outbreak study Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: An in-vitro and ex-vivo study Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in United Arab Emirates Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Severe respiratory illness caused by a novel coronavirus Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Human betacoronavirus 2c EMC/2012-related viruses in bats MERS-related betacoronavirus in Vespertilio superans bats Group C betacoronavirus in bat guano fertilizer Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Close relative of human Middle East respiratory syndrome coronavirus in bat Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus Discovery of Novel Bat An outbreak investigation Human infection with MERS coronavirus after exposure to infected camels Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Antibodies against MERS coronavirus in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-alpha treatment TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection An overview of their replication and pathogenesis keywords: coronavirus; cov; dpp4; east; host; infection; mers; middle; syndrome cache: cord-306004-amv0los1.txt plain text: cord-306004-amv0los1.txt item: #279 of 515 id: cord-306923-eujbxdqi author: Ahmed, Anwar E. title: Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study date: 2018-04-25 words: 2710 flesch: 39 summary: The Poisson and negative binomial models were used to model the frequency of recovery delay in days and identify unadjusted and adjusted factors associated with longer recovery delay. key: cord-306923-eujbxdqi authors: Ahmed, Anwar E.; Al‐Jahdali, Hamdan; Alaqeel, Mody; Siddiq, Salma S.; Alsaab, Hanan A.; Sakr, Ezzeldin A.; Alyahya, Hamed A.; Alandonisi, Munzir M.; Subedar, Alaa T.; Ali, Yosra Z.; Al Otaibi, Hazza; Aloudah, Nouf M.; Baharoon, Salim; Al Johani, Sameera; Alghamdi, Mohammed G. title: Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study date: 2018-04-25 journal: keywords: delay; diagnosis; mers; patients; recovery; study cache: cord-306923-eujbxdqi.txt plain text: cord-306923-eujbxdqi.txt item: #280 of 515 id: cord-307067-cpc1yefj author: van Doremalen, Neeltje title: A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques date: 2020-06-10 words: 6256 flesch: 45 summary: To investigate whether vaccination with ChAdOx1 MERS vaccination provides protection against a variety of different MERS-CoV strains, we vaccinated BALB/c mice transgenic for hDPP4 with ChAdOx1 MERS or ChAdOx1 GFP 28 days before challenge with 10 4 TCID 50 of one of six diverse MERS-CoV strains ( fig. In the current manuscript, we show that a single dose of ChAdOx1 MERS vaccine protects rhesus macaque model against a mucosal challenge with HCoV-EMC/2012. keywords: animals; boost; chadox1; cov; dpi; fig; gfp; group; lung; mers; middle; prime; tissue; vaccination; vaccine; virus cache: cord-307067-cpc1yefj.txt plain text: cord-307067-cpc1yefj.txt item: #281 of 515 id: cord-307109-nz8qvuw6 author: Martinez, Miguel Angel title: Compounds with Therapeutic Potential against Novel Respiratory 2019 Coronavirus date: 2020-04-21 words: 3767 flesch: 35 summary: Thus, protection against influenza virus infections was achieved by targeting TLR4 with small-molecule antagonists, like TAK-242, or with anti-TLR4-specific antibodies (39, 40) . To date, no conclusive results have been found for the effects of immunosuppressants in severe influenza virus infections (12) . keywords: coronavirus; cov; cov-2; human; infections; influenza; mers; novel; remdesivir; sars cache: cord-307109-nz8qvuw6.txt plain text: cord-307109-nz8qvuw6.txt item: #282 of 515 id: cord-307405-qk1ruj5q author: Hall, Aron J. title: Health Care Worker Contact with MERS Patient, Saudi Arabia date: 2014-12-17 words: 1753 flesch: 34 summary: Novel coronavirus (MERS-CoV) Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) into the United States First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities We are extremely grateful for the collaboration of the participating HCW in this investigation. key: cord-307405-qk1ruj5q authors: Hall, Aron J.; Tokars, Jerome I.; Badreddine, Samar A.; Saad, Ziad Bin; Furukawa, Elaine; Al Masri, Malak; Haynes, Lia M.; Gerber, Susan I.; Kuhar, David T.; Miao, Congrong; Trivedi, Suvang U.; Pallansch, Mark A.; Hajjeh, Rana; Memish, Ziad A. title: Health Care Worker Contact with MERS Patient, Saudi Arabia date: 2014-12-17 journal: Emerg Infect Dis DOI: 10.3201/eid2012.141211 sha: doc_id: 307405 cord_uid: qk1ruj5q To investigate potential transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) to health care workers in a hospital, we serologically tested hospital contacts of the index case-patient in Saudi Arabia, 4 months after his death. keywords: case; contact; cov; mers; patient cache: cord-307405-qk1ruj5q.txt plain text: cord-307405-qk1ruj5q.txt item: #283 of 515 id: cord-307811-6e3j0pn7 author: Hao, Wei title: Binding of the SARS-CoV-2 Spike Protein to Glycans date: 2020-07-02 words: 5709 flesch: 47 summary: Binding of the subunits and S proteins of SARS-CoV-2, SARS-CoV, and MERS-CoV to a HS microarray. Additionally, we found that the binding preferences of the RBDs, S1 subunits and full-length S proteins of SARS-CoV and MERS-CoV are similar to those of the subunits and S protein of SARS-CoV-2, although small differences are observed (Fig. keywords: acid; binding; cell; cov-2; microarray; protein; sars; sulfate; surface; virus cache: cord-307811-6e3j0pn7.txt plain text: cord-307811-6e3j0pn7.txt item: #284 of 515 id: cord-307853-m1q1sjr4 author: Majumder, Satyabrata title: Exploring the intrinsic dynamics of SARS-CoV-2, SARS-CoV and MERS-CoV spike glycoprotein through normal mode analysis using anisotropic network model date: 2020-10-16 words: 3051 flesch: 48 summary: Detailed domain-wise motion, atomic fluctuation data and quantitative comparison between S protein structures of the mentioned viruses will aid in identifying common potential drug binding hotspots in the receptor binding domain of the protein which will guide in designing common inhibitor or modified version of these molecules through structure-based approach. As a large part of this study is involved in the comparative analysis purposes, we have discarded part of the S2 region of S protein of all viral strains so that each protein model has equal number of Cα atoms (1087 in all three chains). keywords: cov; cov-2; dynamics; protein; receptor; sars; spike; state cache: cord-307853-m1q1sjr4.txt plain text: cord-307853-m1q1sjr4.txt item: #285 of 515 id: cord-307995-8q7efrqk author: Al-Tawfiq, Jaffar A. title: Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns date: 2016-05-04 words: 4444 flesch: 51 summary: Mitigation through Detection, Research, and Response Saudi Arabia and the emergence of a novel coronavirus Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia An update on Middle East respiratory syndrome: 2 years later Health care worker contact with MERS patient, Saudi Arabia Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Middle East respiratory syndrome coronavirus case definition for reporting to WHO: interim case definition 14 Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Family cluster of Middle East respiratory syndrome coronavirus infections A family cluster of Middle East Respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study KSA MERS-CoV Investigation Team. Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia Imported cases of Middle East respiratory syndrome: an update The Hajj pilgrimage and surveillance for Middle East Respiratory syndrome coronavirus in pilgrims from African countries High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia Transmission of MERS-coronavirus in household contacts Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Heat inactivation of the Middle East respiratory syndrome coronavirus Infection prevention and control of epidemic-and pandemic prone acute respiratory infections in health care Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus Treating MERS-CoV during an outbreak Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel coronavirus replication by a combination of interferon-α2b and ribavirin Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Combination therapy with lopinavir/ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report keywords: cases; coronavirus; cov; east; infection; mers; middle; patients; syndrome; transmission cache: cord-307995-8q7efrqk.txt plain text: cord-307995-8q7efrqk.txt item: #286 of 515 id: cord-308061-hz7fsn2g author: Drosten, Christian title: Is MERS another SARS? date: 2013-09-30 words: 1064 flesch: 43 summary: 4 However, in general, the prevalence of ceftriaxone Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Severe respiratory illness caused by a novel coronavirus Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study The severe acute respiratory syndrome Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Prevalence of diabetes mellitus in a Saudi community Hospital outbreak of Middle East respiratory syndrome coronavirus Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confi rmation of novel human coronavirus (hCoV-EMC) infections Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection and the MERS-CoV study group. Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk keywords: coronavirus; mers; patients; sars cache: cord-308061-hz7fsn2g.txt plain text: cord-308061-hz7fsn2g.txt item: #287 of 515 id: cord-308340-p2iqzyv4 author: Devitt, Elizabeth title: Lack of small animal model hinders MERS coronavirus research date: 2013-08-06 words: 926 flesch: 55 summary: Specifically, the researchers are evaluating whether two antiviral compounds-alpha-interferon and ribavirin, both of which are used to treat hepatitis and other infections-can clear MERS coronavirus infections. Fortunately for MERS researchers laboring to develop an animal model before the viral outbreak gets out of hand, time seems to be on their side. keywords: coronavirus; mers; virus cache: cord-308340-p2iqzyv4.txt plain text: cord-308340-p2iqzyv4.txt item: #288 of 515 id: cord-309010-tmfm5u5h author: Dietert, Kristina title: Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia date: 2017-11-20 words: 7851 flesch: 26 summary: https://doi.org/10.1371/journal.pone.0188251.g010 Comparative histopathology of mouse models of acute pneumonia semiquantification of mouse pneumonia is inconceivable. Murine acute lung infection models mirror human pathologies in many aspects and contribute to our understanding of the disease and the development of novel treatment strategies. keywords: + +; acute; alveolar; cov; fig; iav; infection; lesions; lung; mers; mice; model; mouse; pathogen; pneumonia cache: cord-309010-tmfm5u5h.txt plain text: cord-309010-tmfm5u5h.txt item: #289 of 515 id: cord-309081-v098m4dc author: Bin Saeed, Abdulaziz A. title: Surveillance and Testing for Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, April 2015–February 2016 date: 2017-04-17 words: 1519 flesch: 44 summary: To determine the extent of MERS surveillance in Saudi Arabia, we reviewed electronic surveillance data collected during April 1, 2015-February 1, 2016, to describe trends in surveillance for MERS and to compare demographic and clinical features among persons tested. WHO statement on the tenth meeting of the IHR Emergency Committie regarding MERS Case definition and management of patients with MERS coronavirus in Saudi Arabia Ministry of Health Kingdom of Saudi Arabia, Scientific Advisory Board. keywords: case; cov; mers; persons cache: cord-309081-v098m4dc.txt plain text: cord-309081-v098m4dc.txt item: #290 of 515 id: cord-309089-ex9nh1yi author: Coperchini, Francesca title: The Cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system date: 2020-05-11 words: 6141 flesch: 37 summary: An interferon-gamma-related cytokine storm in SARS patients Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells Pathogenesis of severe acute respiratory syndrome Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome Induction of IL-8 release in lung cells via activator protein-1 by recombinant baculovirus displaying severe acute respiratory syndrome-coronavirus spike proteins: identification of two functional regions A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection Age-related increases in PGD(2) -Tumor necrosis factor α (TNFα) is a pyrogen cytokine released from immune cells in the acute phase of inflammation and infection. keywords: acute; cells; chemokines; coronavirus; cov; covid-19; cxcl10; cytokine; immune; infection; patients; sars; syndrome cache: cord-309089-ex9nh1yi.txt plain text: cord-309089-ex9nh1yi.txt item: #291 of 515 id: cord-309239-6lso1w0o author: Adney, Danielle R. title: Inoculation of Goats, Sheep, and Horses with MERS-CoV Does Not Result in Productive Viral Shedding date: 2016-08-19 words: 2991 flesch: 46 summary: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Rooting the phylogenetic tree of Middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) origin and animal reservoir Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Serologic assessment of possibility for MERS-CoV infection in equids Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Replicative capacity of MERS coronavirus in livestock cell lines Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in Alpacas Infection with MERS-CoV causes lethal pneumonia in the common marmoset Experimental infection and response to rechallenge of Alpacas with Middle East respiratory syndrome coronavirus The goat kids were maintained at all times in a room with their mothers, who served as in-contact controls to test for virus transmission. keywords: cov; goats; mers; sheep; virus cache: cord-309239-6lso1w0o.txt plain text: cord-309239-6lso1w0o.txt item: #292 of 515 id: cord-309518-seonrtn3 author: Alraddadi, Basem M. title: Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome date: 2019-03-18 words: 1999 flesch: 36 summary: ICU and hospital length of stay were similar between NIV patients and invasive MV patients. There was no significant difference in the duration of invasive MV and total duration of NIV and invasive MV between the two groups, although invasive MV-free days and total NIV and invasive MV-free days were significantly longer among NIV patients compared to invasive MV patients (Table 2, Figure S2 ). keywords: niv; patients; respiratory; syndrome; ventilation cache: cord-309518-seonrtn3.txt plain text: cord-309518-seonrtn3.txt item: #293 of 515 id: cord-309621-6jj19xpr author: Yu, Pin title: Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus date: 2017-02-24 words: 4647 flesch: 36 summary: Here, we comprehensively describe the histopathological features of the disease and the distribution of the MERS-CoV antigen and DDP4 in rhesus macaque and common marmoset models. key: cord-309621-6jj19xpr authors: Yu, Pin; Xu, Yanfeng; Deng, Wei; Bao, Linlin; Huang, Lan; Xu, Yuhuan; Yao, Yanfeng; Qin, Chuan title: Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus date: 2017-02-24 journal: PLoS One DOI: 10.1371/journal.pone.0172093 sha: doc_id: 309621 cord_uid: 6jj19xpr Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged. keywords: alveolar; cells; cov; infection; lungs; macaques; marmosets; mers; pneumocytes; rhesus cache: cord-309621-6jj19xpr.txt plain text: cord-309621-6jj19xpr.txt item: #294 of 515 id: cord-309734-m8miwtha author: Vergara‐Alert, J. title: Middle East respiratory syndrome coronavirus experimental transmission using a pig model date: 2017-06-26 words: 1793 flesch: 51 summary: Transbound Emerg Dis DOI: 10.1111/tbed.12668 sha: doc_id: 309734 cord_uid: m8miwtha Dromedary camels are the main reservoir of Middle East respiratory syndrome coronavirus (MERS‐CoV), but other livestock species (i.e., alpacas, llamas, and pigs) are also susceptible to infection with MERS‐CoV. Animal‐to‐animal transmission in alpacas was reported, but evidence for transmission in other species has not been proved. Middle East respiratory syndrome coronavirus (MERS-CoV) was first detected in 2012 in Saudi Arabia, and it causes severe acute respiratory illness with fever, cough and shortness of breath (Zaki, van Boheemen, Bestebroer, Osterhaus, & Fouchier, 2012) . keywords: coronavirus; cov; mers; pigs cache: cord-309734-m8miwtha.txt plain text: cord-309734-m8miwtha.txt item: #295 of 515 id: cord-309898-sju15hev author: Hu, Yiwen title: Comparative analysis of nanomechanical features of coronavirus spike proteins and correlation with lethality and infection rate date: 2020-11-02 words: 4297 flesch: 39 summary: key: cord-309898-sju15hev authors: Hu, Yiwen; Buehler, Markus J. title: Comparative analysis of nanomechanical features of coronavirus spike proteins and correlation with lethality and infection rate date: 2020-11-02 journal: Matter DOI: 10.1016/j.matt.2020.10.032 sha: doc_id: 309898 cord_uid: sju15hev The novel coronavirus disease, COVID-19, has spread rapidly around the world. Here, we provide a novel way in understanding coronavirus spike proteins, connecting their nanomechanical features – specifically its vibrational spectrum and quantitative measures of mobility – with virus lethality and infection rate. keywords: coronavirus; cov; cov-2; flexibility; protein; rbd; receptor; sars; spike cache: cord-309898-sju15hev.txt plain text: cord-309898-sju15hev.txt item: #296 of 515 id: cord-310071-d195rumq author: Lee, Jacob title: Collaborative Intervention of Middle East Respiratory Syndrome: Rapid Response Team date: 2016-06-30 words: 2055 flesch: 58 summary: [3] [4] [5] RRT's individualized strategies for hospitals exposed to MERS RRT conducted a consultation directly to hospitals where MERS patients occurred. As considering KCDC's faults, we began to isolate close contacts early about hospitals where there were MERS patients. keywords: hospitals; mers; patients; rrt cache: cord-310071-d195rumq.txt plain text: cord-310071-d195rumq.txt item: #297 of 515 id: cord-310297-sbxlz04w author: Al Awaidy, Salah T. title: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Oman: Current Situation and Going Forward date: 2019-05-17 words: 1317 flesch: 51 summary: 5 As of January 2019, a total of 2298 laboratoryconfirmed human cases of MERS-CoV from 27 countries have been reported, including 811 associated deaths giving a fatality rate of 35.2%. Eighty percent of cases have been reported from countries of the World Health Organization Eastern Mediterranean Region. keywords: camels; cases; cov; mers cache: cord-310297-sbxlz04w.txt plain text: cord-310297-sbxlz04w.txt item: #298 of 515 id: cord-311176-dlwph5za author: Alshahrani, Mohammed S. title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus date: 2018-01-10 words: 3697 flesch: 44 summary: Blood flow (L min −1 ), revolutions per minute, and sweep gas among ECMO patients had a mean (SD) of 3.8 (0.77), 3148.7 ECMO-related mechanical complications occurred in 3 (18%) patients; one patient developed pneumothorax that was treated with chest tube insertion, and two patients had major bleeding immediately after the initiation of ECMO. In regard to infection control issues, caregivers safety of ECMO patients was organized and maintained by aggressive measures which were applied strictly and monitored closely with all admissions were taken to airborne isolated rooms which impacted the containment of the virus plus applying the universal protective personal measures all the time during the patients encounter. keywords: cov; ecmo; group; mers; oxygenation; patients; study; syndrome; use cache: cord-311176-dlwph5za.txt plain text: cord-311176-dlwph5za.txt item: #299 of 515 id: cord-311937-6hadssmh author: Sherbini, Nahid title: Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data date: 2016-06-11 words: 2860 flesch: 49 summary: Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 Family cluster of Middle East respiratory syndrome coronavirus infections Prevalence of diabetes mellitus in a Saudi community Severe acute respiratory syndrome and coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection A major outbreak of severe acute respiratory syndrome in Hong Kong Clinical and laboratory features in the early stage of severe acute respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings This study did not receive funding. This study describes the clinical characteristics and outcome of MERS infected patients. keywords: cases; coronavirus; cov; infection; mers; patients; study cache: cord-311937-6hadssmh.txt plain text: cord-311937-6hadssmh.txt item: #300 of 515 id: cord-312038-g76cpjp7 author: Brunaugh, Ashlee D. title: Broad-Spectrum, Patient-Adaptable Inhaled Niclosamide-Lysozyme Particles are Efficacious Against Coronaviruses in Lethal Murine Infection Models date: 2020-10-07 words: 11069 flesch: 39 summary: Though hLYS is surface active, it appeared to only slightly enhance the dissolution of NIC compared to NIC particles blended with lactose (F). We have previously demonstrated that hen egg white lysozyme is robust to processinduced aggregation using typical particle engineering techniques (51) , which provided part of the rationale for its selection as a therapeutically active carrier for the aerosol delivery of NIC particles. keywords: activity; cells; cov-2; covid-19; delivery; dose; drug; fig; formulation; hlys; infection; lung; mers; mice; nic; niclosamide; particles; powder; sars; spray; study; treatment cache: cord-312038-g76cpjp7.txt plain text: cord-312038-g76cpjp7.txt item: #301 of 515 id: cord-312178-tojgojjf author: Segars, James title: Prior and Novel Coronaviruses, COVID-19, and Human Reproduction: What Is Known? date: 2020-04-16 words: 5366 flesch: 41 summary: An in silico analysis Structure, Function, and Evolution of Coronavirus Spike Proteins Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptorbinding site in spike protein domain A Structural insights into coronavirus entry Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains Ezrin interacts with the SARS coronavirus Spike protein and restrains infection at the entry stage Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways In a 2005 study of eight postmortem SARS-CoV patients, testicular tissue contained focal atrophy despite lacking identifiable SARS viral RNA (24) . keywords: case; coronavirus; cov-2; covid-19; disease; infection; patients; pregnancy; reports; sars; transmission; women cache: cord-312178-tojgojjf.txt plain text: cord-312178-tojgojjf.txt item: #302 of 515 id: cord-312434-yx24golq author: Deng, Ziqin title: Bibliometric and Visualization Analysis of Human Coronaviruses: Prospects and Implications for COVID-19 Research date: 2020-09-23 words: 6227 flesch: 40 summary: Leading researchers from various fields of human coronavirus research are listed to facilitate collaboration and promote effective disease prevention and control. This is partially due to the unclear knowledge map of human coronavirus research and an inadequate understanding of the present research status, hotspots and development trends. keywords: analysis; coronavirus; cov; covid-19; human; mers; outbreak; publications; research; sars cache: cord-312434-yx24golq.txt plain text: cord-312434-yx24golq.txt item: #303 of 515 id: cord-312533-4u3bmb0e author: Shen, Li Wen title: TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections date: 2017-08-01 words: 4788 flesch: 31 summary: influenza A virus hemagglutinin affects host-specific virus infection Composition and functions of the influenza fusion peptide Host cell proteases: critical determinants of coronavirus tropism and pathogenesis Mechanisms of coronavirus cell entry mediated by the viral spike protein A structural view of coronavirusereceptor interactions DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors Proteolytic activation of the 1918 influenza virus hemagglutinin Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity Protease inhibitors targeting coronavirus and filovirus entry Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus Human coronaviruses: a review of virusehost interactions TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice Aprotinin and similar protease inhibitors as drugs against influenza The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells Retinoids in liver fibrosis and cancer Antiproteases in the treatment of chronic pancreatitis Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects Evaluation of anti-influenza effects of camostat in mice infected with non-adapted human influenza viruses Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection Identification of nafamostat as a potent inhibitor of Middle East Respiratory Syndrome Coronavirus S protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition Different host cell proteases activate the SARS-coronavirus spike-protein for cellecell and virusecell fusion Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation A serpin shapes the extracellular environment to prevent influenza A virus maturation Inhibition of influenza virus infection and hemagglutinin cleavage by the protease inhibitor HAI-2 In animal models, infection of wild-type mice with H7N9 influenza virus (A/Anhui/1/13) and H1N1 influenza virus (A/ PR/8/34) led to severe disease with mortality rates of 100% and 20%, respectively; whereas in TMPRSS2-deficient mice, these viruses were a pathogenic [20] . keywords: cells; coronavirus; cov; h1n1; infection; influenza; mers; protease; sars; serine; tmprss2; virus cache: cord-312533-4u3bmb0e.txt plain text: cord-312533-4u3bmb0e.txt item: #304 of 515 id: cord-312670-hi3fjne4 author: Corman, V. M. title: Coronaviren als Ursache respiratorischer Infektionen date: 2019-08-27 words: 2308 flesch: 41 summary: Bei komplizierten Verläufen und schweren Infektionen des Respirationstrakts ist eine Testung auf CoV mittels Echtzeit-Reverse-Transkriptase-Polymerase-Kettenreaktion (RT-PCR) möglich und sinnvoll. Neben dem regelhaften Nachweis von CoV keywords: auch; auf; bei; coronavirus; cov; den; der; die; eine; hcov; infektionen; ist; mers; mit; sars; sind; syndrome; und cache: cord-312670-hi3fjne4.txt plain text: cord-312670-hi3fjne4.txt item: #305 of 515 id: cord-312691-ynh84b98 author: Mohd, Hamzah A. title: Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia date: 2016-09-24 words: 3297 flesch: 47 summary: Kingdom of Saudi Arabia: Ministry of Health (MOH) Evidence for camel-to-human transmission of MERS coronavirus Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Middle East Respiratory Syndrome Coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Antibodies against MERS coronavirus in dromedary camels Middle East Respiratory Syndrome Coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia An observational, laboratory-based study of outbreaks of Middle East Respiratory Syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia Hospital-associated outbreak of Middle East Respiratory Syndrome Coronavirus: a serologic, epidemiologic, and clinical description Hospital outbreak of Middle East Respiratory Syndrome Coronavirus Synthesizing data and models for the spread of MERS-CoV, 2013: key role of index cases and hospital transmission Middle East Respiratory Syndrome Coronavirus: a case-control study of hospitalized patients Clinical aspects and outcomes of 70 patients with Middle East Respiratory Syndrome Coronavirus infection: a singlecenter experience in Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East Respiratory Syndrome Coronavirus disease from Saudi Arabia: a descriptive study Infection prevention and control guidelines for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection Imported cases of Middle East Respiratory Syndrome: an update Travel implications of emerging coronaviruses: SARS and MERS-CoV Middle East Respiratory Syndrome Coronavirus: current situation and travelassociated concerns Presence of Middle East Respiratory Syndrome Coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study An adult returned traveler from Dubai hospitalized with an influenzalike illness (ILI): Middle East Respiratory Syndrome (MERS) or influenza? Infection control implications from a Near MERS case Middle East Respiratory Syndrome (MERS): a zoonotic viral pneumonia Serial intervals of respiratory infectious diseases: a systematic review and analysis Cluster of Middle East Respiratory Syndrome coronavirus infections in Iran None of the authors declared COI. keywords: coronavirus; cov; east; infection; mers; patients; syndrome cache: cord-312691-ynh84b98.txt plain text: cord-312691-ynh84b98.txt item: #306 of 515 id: cord-312692-jv3425w1 author: Iwata-Yoshikawa, Naoko title: Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus date: 2019-01-09 words: 8569 flesch: 50 summary: When we asked why the Tg2 mice showed nonlethal responses to infection, we could not ignore the fact that virus levels in lungs were lower than those reported for other MERS mouse models (5, 12, 13, 38, 39) . (C) Genomic DNA was extracted from Tg2 mice, and human DPP4 exons 1 to 26 were subjected to PCR using specific primers. keywords: cells; cov; days; fig; hdpp4; human; infection; lungs; mers; mice; model; mouse; p.i; syndrome; tg2; week cache: cord-312692-jv3425w1.txt plain text: cord-312692-jv3425w1.txt item: #307 of 515 id: cord-312740-2ro2p77q author: Babadaei, Mohammad Mahdi Nejadi title: Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase date: 2020-05-20 words: 3826 flesch: 36 summary: Also, it was shown that the type of CoV, concentration of antiviral drug, type of anti-viral drug, and incubation time can play an important role on the inhibition of virus infection ( Figure 2B Figure 4) . There is no therapeutic FDA-approved drug against SARS-CoV-2 infection, although a combination of anti-viral drugs is directly being practiced in some countries. keywords: coronavirus; cov; cov-2; covid-19; et al; mers; rdv; sars; virus cache: cord-312740-2ro2p77q.txt plain text: cord-312740-2ro2p77q.txt item: #308 of 515 id: cord-312741-0au4nctt author: Lin, Panpan title: Coronavirus in human diseases: Mechanisms and advances in clinical treatment date: 2020-10-01 words: 14692 flesch: 30 summary: The 9-kDa hydrophobic protein encoded at the 3' end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated Mouse hepatitis virus gene 5b protein is a new virion envelope protein Infectious bronchitis virus E protein is targeted to the Golgi complex and directs release of virus-like particles A comprehensive comparison of transmembrane domains reveals organelle-specific properties Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer Assembly of the coronavirus envelope: homotypic interactions between the M proteins SARS coronavirus E protein forms cation-selective ion channels Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors The transmembrane domain of the infectious bronchitis virus E protein is required for efficient virus release Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells Role of the coronavirus E viroporin protein transmembrane domain in virus assembly Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis Heterologous gene expression from transmissible gastroenteritis virus replicon particles Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome The small envelope protein E is not essential for murine coronavirus replication A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway Characterization of severe acute respiratory syndrome coronavirus membrane protein Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus Genetic evidence for a structural interaction between the carboxy termini of the membrane and nucleocapsid proteins of mouse hepatitis virus The molecular biology of coronaviruses A structural analysis of M protein in coronavirus assembly and morphology Envelope glycoprotein interactions in coronavirus assembly Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system Coronaviruses: an overview of their replication and pathogenesis Nucleocapsidindependent assembly of coronavirus-like particles by co-expression of viral envelope protein genes Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction The missing link in coronavirus assembly. syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization Identification of in vivointeracting domains of the murine coronavirus nucleocapsid protein Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1 Theoretical aspects of virus capsid assembly Analysis of multimerization of the SARS coronavirus nucleocapsid protein Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein Envelope protein palmitoylations are crucial for murine coronavirus assembly The hydrophobic domain of infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus The coronavirus E protein: assembly and beyond Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes The intracellular sites of early replication and budding of SARS-coronavirus Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer Glycan shield and epitope masking of a coronavirus spike protein observed by cryoelectron microscopy Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains A human homolog of angiotensin-converting enzyme. keywords: binding; cells; coronavirus; cov; covid-19; covs; domain; east; entry; fusion; host; human; infection; inhibitors; membrane; mers; middle; novel; patients; protein; receptor; replication; rna; sars; sars coronavirus; spike; syndrome; syndrome coronavirus; treatment cache: cord-312741-0au4nctt.txt plain text: cord-312741-0au4nctt.txt item: #309 of 515 id: cord-313028-0nhgxoim author: Huang, Chaolin title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China date: 2020-01-24 words: 4834 flesch: 46 summary: KDIGO clinical practice guideline for acute kidney injury CDC definitions for nosocomial infections Association between cardiac injury and mortality in hospitalized patients infected with avian influenza A (H7N9) virus Coronaviruses post-SARS: update on replication and pathogenesis A major outbreak of severe acute respiratory syndrome in Hong Kong Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques SARS: systematic review of treatment effects Corticosteroids as adjunctive therapy in the treatment of influenza Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Origin and evolution of pathogenic coronaviruses Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting We acknowledge all health-care workers involved in the diagnosis and treatment of patients in Wuhan; we thank the Chinese National Health Commission for coordinating data collection for patients with 2019-nCoV infection; we thank WHO and the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) for sharing data collection templates publicly on the website; and we thank Prof Chen Wang and Prof George F Gao for guidance in study design and interpretation of results. Plasma levels of IL5, IL12p70, IL15, Eotaxin, and RANTES were similar between healthy adults and patients infected with 2019-nCoV. Further comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNFα were higher in ICU patients than non-ICU patients. keywords: acute; clinical; coronavirus; data; icu; infection; mers; ncov; novel; patients; respiratory; sars cache: cord-313028-0nhgxoim.txt plain text: cord-313028-0nhgxoim.txt item: #310 of 515 id: cord-313054-w90eitw9 author: Mobaraki, Kazhal title: Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1.2017 to 17.1.2018: a cross-sectional study date: 2019-04-27 words: 2190 flesch: 51 summary: The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea Middle East respiratory syndrome coronavirus Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Middle East respiratory syndrome coronavirus: review of the current situation in the world Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Isolation of MERS coronavirus from a dromedary camel Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE World Organization Health Middle East respiratory syndrome Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Hadj ritual and risk of a pandemic Transmission scenarios for Middle East respiratory syndrome coronavirus (MERS-CoV) and how to tell them apart Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Middle East respiratory syndrome novel corona (MERS-CoV) infection. The authors take this opportunity to thank all the WHO personnel as well as reporting countries with confirmed MERS cases for data collection and sending the data to WHO. keywords: cases; coronavirus; cov; mers; syndrome cache: cord-313054-w90eitw9.txt plain text: cord-313054-w90eitw9.txt item: #311 of 515 id: cord-313517-5ipj2z86 author: Fung, Joshua title: Antigen Capture Enzyme-Linked Immunosorbent Assay for Detecting Middle East Respiratory Syndrome Coronavirus in Humans date: 2019-09-14 words: 2711 flesch: 45 summary: World Health Organization, 20 Avenue Appia Laboratory Testing for Middle East Respiratory Syndrome Coronavirus A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Are other fluorescent tags used instead of ethidium bromide safer Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia A highly specific rapid antigen detection assay for on-site diagnosis of MERS Rapid detection of MERS coronavirus-like viruses in bats: pote1n-tial for tracking MERS coronavirus transmission and animal origin Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus Differential diagnosis of pandemic (H1N1) 2009 infection by detection of haemagglutinin with an enzyme-linked immunoassay SARS coronavirus detection methods Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in sars patients by enzyme-linked immunosorbent assay Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests 1. key: cord-313517-5ipj2z86 authors: Fung, Joshua; Lau, Susanna K. P.; Woo, Patrick C. Y. title: Antigen Capture Enzyme-Linked Immunosorbent Assay for Detecting Middle East Respiratory Syndrome Coronavirus in Humans date: 2019-09-14 journal: MERS Coronavirus DOI: 10.1007/978-1-0716-0211-9_7 sha: doc_id: 313517 cord_uid: 5ipj2z86 The Middle East respiratory syndrome (MERS) is the second novel zoonotic disease infecting humans caused by coronavirus (CoV) in this century. keywords: antigen; assay; capture; coronavirus; cov; elisa; mers; plate cache: cord-313517-5ipj2z86.txt plain text: cord-313517-5ipj2z86.txt item: #312 of 515 id: cord-313684-61hkogdh author: Samaddar, Arghadip title: Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena date: 2020-09-17 words: 11716 flesch: 34 summary: There are currently four ongoing clinical trials of umifenovir for COVID-19 treatment: one in comparison with the basic treatment 6 , and the other three comparing the effects in combination with oseltamivir 7 , lopinavir/ ritonavir 8 , and carrimycin. Currently, there are no clinically proven antiviral drugs or biologics for the treatment of COVID-19 patients. keywords: acute; antiviral; cells; combination; coronavirus; cov-2; covid-19; covid-19 patients; disease; et al; host; immune; infection; mers; patients; protein; receptors; response; rna; sars; therapy; treatment; trial; viral; virus cache: cord-313684-61hkogdh.txt plain text: cord-313684-61hkogdh.txt item: #313 of 515 id: cord-313737-cob5hf5q author: Otter, J. A. title: The inaugural Healthcare Infection Society Middle East Summit: ‘No action today. No cure tomorrow.’ date: 2015-11-30 words: 1672 flesch: 48 summary: Valerie Harmon delivered a useful lecture on achieving hand hygiene compliance. The problem with using human beings to monitor hand hygiene compliance is that the moment another person is there, compliance improves! keywords: cov; hand; hygiene; infection; mers; middle cache: cord-313737-cob5hf5q.txt plain text: cord-313737-cob5hf5q.txt item: #314 of 515 id: cord-314357-u1m7yr8f author: Elrggal, Mahmoud E. title: Evaluation of preparedness of healthcare student volunteers against Middle East respiratory syndrome coronavirus (MERS-CoV) in Makkah, Saudi Arabia: a cross-sectional study date: 2018-04-14 words: 2786 flesch: 47 summary: These findings have put Saudi Arabia at the epicenter of deadly outbreaks of MERS-CoV. The transmission of MERS-CoV through person-to-person contact has been confirmed as one of the multiple routes of transmission of MERS outbreaks in Saudi Arabia (Assiri et al. 2013; Memish et al. 2013a, b) . For example, the hospitalbased emergence of MERS during spring 2013 in Al-Ahsa (eastern province of Saudi Arabia) was the result of humanto-human transmission with the spread largely suspected to occur through large droplets and contact (Assiri et al. 2013) . keywords: arabia; mers; saudi; students; study cache: cord-314357-u1m7yr8f.txt plain text: cord-314357-u1m7yr8f.txt item: #315 of 515 id: cord-314651-e4uaw5fy author: Zhao, Guangyu title: Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus date: 2015-12-23 words: 4174 flesch: 38 summary: Systemic inflammation is believed to be a primary reason for the severe outcome in MERS--CoV infections [14, 24] . To evaluate MERS-CoV infection in the hDPP4 transgenic mice, distribution of the viral antigen NP protein was assessed in mouse tissues by immunohistochemical staining. keywords: coronavirus; cov; day; east; fig; hdpp4; infection; mers; mice; syndrome; transgenic cache: cord-314651-e4uaw5fy.txt plain text: cord-314651-e4uaw5fy.txt item: #316 of 515 id: cord-314867-qg3hl5ft author: Yoon, Ji Hye title: Study on the 2‐Phenylchroman‐4‐One Derivatives and their anti‐MERS‐CoV Activities date: 2019-07-28 words: 1218 flesch: 55 summary: We screened a variety of natural products against MERS-CoV as an attempt of developing anti-MERS-CoV drugs, and many flavonoids showed anti-MERS activities. As a conclusion, a series of 2-phenylchroman-4-one derivatives were synthesized for the chemical modifications of bavachin, and they exhibited anti-MERS activities in vero cell. keywords: anti; derivatives; mers cache: cord-314867-qg3hl5ft.txt plain text: cord-314867-qg3hl5ft.txt item: #317 of 515 id: cord-315234-pqn7qhm8 author: None title: An Unexpected Outbreak of Middle East Respiratory Syndrome Coronavirus Infection in the Republic of Korea, 2015 date: 2015-06-30 words: 1035 flesch: 50 summary: He decided to move from hospital A to receive better care, and then visited another clinic and emergency room of hospital B in Seoul on May 17. The outbreak is now the second largest worldwide and the largest reported outside the Middle East region owing to larg-er population density in the Far East region, especially with large hospitals [1, 2] . keywords: hospital; infection; mers cache: cord-315234-pqn7qhm8.txt plain text: cord-315234-pqn7qhm8.txt item: #318 of 515 id: cord-315316-w7cn9iqp author: Earnest, James T. title: The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases date: 2017-07-31 words: 7897 flesch: 44 summary: The observation that a single tetraspanin family member, CD9, promoted cell entry for some, but not all CoVs, suggested that CD9 interacts with one or more MERS-CoV and 229E-CoV entry factors. Here we demonstrated that the virulent MA MERS-CoV S proteins utilized CD9 during cell entry, while avirulent CCA viruses did not. keywords: cd81; cd9; cells; coronavirus; cov; entry; factors; fig; fusion; hdpp4; human; infection; mers; mouse; proteins; receptor; tetraspanin; tmprss2; virus cache: cord-315316-w7cn9iqp.txt plain text: cord-315316-w7cn9iqp.txt item: #319 of 515 id: cord-315437-h6xjudm0 author: Nyon, Mun Peak title: Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen date: 2018-03-27 words: 6656 flesch: 42 summary: While these mAbs bound strongly to the non-denatured (no DTT) S377-588-Fc proteins expressed in both adCHO and HEK293T, they had significantly reduced affinity to RBD proteins treated with DTT, a reducing agent cleaving disulfide bonds of RBDs and thus disrupting a protein's native conformation (Fig. 4e) . Middle East respiratory syndrome coronavirus The middle east respiratory syndrome coronavirus -a continuing risk to global health security Vaccine development against prioritized epidemic infectious diseases Inovio Reports New Positive Clinical Data on Vaccine Advances in the Fight Against Emerging Infectious Diseases Innate immune signaling by, and genetic adjuvants for DNA vaccination The future of human DNA vaccines Receptor recognition mechanisms of coronaviruses: a decade of structural studies Middle East respiratory syndrome: current status and future prospects for vaccine development Vaccines for the prevention against the threat of MERS-CoV Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome Receptor-binding domain-based subunit vaccines against MERS-CoV Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments-the importance of immunofocusing in subunit vaccine design Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus Recombinant receptorbinding domains of multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) induce cross-neutralizing antibodies against divergent human and camel MERS-CoVs and antibody escape mutants Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transgenic mice from MERS-CoV infection A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Characteristics of early-and lateonset rapid eye movement sleep behavior disorder in China: a case-control study Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Characterization and demonstration of the value of a lethal mouse model of Middle East respiratory syndrome coronavirus infection and disease Evaluation of stable and highly productive gene amplified CHO cell line based on the location of amplified genes A recombinant receptorbinding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection Junctional and allelespecific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus Optimized signal peptides for the development of high expressing CHO cell lines MERS-CoV spike protein: a key target for antivirals Evaluation of transfection methods for transient gene expression in Chinese hamster ovary cells Gene expression in Mammalian cells and its applications Designing CD4 immunoadhesins for AIDS therapy Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice A neonatal Fc receptortargeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice Fc-fusion proteins: new developments and future perspectives Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds A plea to reduce or replace fetal bovine serum in cell culture media Advances in Mammalian cell line development technologies for recombinant protein production Identification of a receptorbinding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction This study was supported through the US-Malaysian Vaccine Development Program, funded by the University of Malaya, and grants from the NIH (R01AI098775-03S1 and R21AI128311). keywords: adcho; binding; cells; cov; fig; human; medium; mers; mers s377; mice; protein; rbd; s377; signal; vaccine cache: cord-315437-h6xjudm0.txt plain text: cord-315437-h6xjudm0.txt item: #320 of 515 id: cord-315909-vwugf0wp author: Letko, Michael title: Studying Evolutionary Adaptation of MERS-CoV date: 2019-09-14 words: 1239 flesch: 44 summary: Semi-permissive cells: baby hamster kidney (BHK) cells which have been transduced to stably express Desmodus rotundus DPP4 (drDPP4 At least three replicates (well of semi-permissive cells) for each forced adaptation experiment should be performed in parallel. keywords: cells; culture; mers; mutations; virus cache: cord-315909-vwugf0wp.txt plain text: cord-315909-vwugf0wp.txt item: #321 of 515 id: cord-316013-7dckgg6b author: Wang, Lili title: Engineering a Novel Antibody-Peptide Bispecific Fusion Protein Against MERS-CoV date: 2019-11-04 words: 4817 flesch: 42 summary: To further compare the inhibitory effects of fusion proteins, the cell-cell fusion assay was performed as MERS-CoV S protein, which was expressed on the cell surface, can mediate cell fusion with neighboring cells [43] . As shown in Table 1 , all three m336-based fusion proteins (m336 scFv, m336 scFv-pep, and m336 diabody-pep) exhibited potent binding to S protein with very similar binding pattern. keywords: cells; cov; fusion; m336; m336 diabody; m336 scfv; mers; pep; protein cache: cord-316013-7dckgg6b.txt plain text: cord-316013-7dckgg6b.txt item: #322 of 515 id: cord-317061-0bx704ao author: Wu, Andong title: Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus date: 2015-10-02 words: 6019 flesch: 45 summary: The substrate specificity of coronaviruses 3CLpro is determined by the residues from P4 to P2 positions of cleavage sites, especially depending on the P1, P2 and P1 positions, which would benefit the prediction of cleavage site and design the broadspectrum inhibitors of coronaviruses 3CLpro (Chuck et al., 2011; Hegyi and Ziebuhr, 2002) . Our study points out a new direction regarding the prediction and identification of cleavage sites of proteases and contributes to understanding the mechanism of coronaviral polyprotein processing. keywords: 3clpro; cleavage; cleavage sites; coronavirus; cov; fig; luciferase; mers; sites; substrate cache: cord-317061-0bx704ao.txt plain text: cord-317061-0bx704ao.txt item: #323 of 515 id: cord-317232-qk72i0gv author: Gierer, Stefanie title: Inhibition of Proprotein Convertases Abrogates Processing of the Middle Eastern Respiratory Syndrome Coronavirus Spike Protein in Infected Cells but Does Not Reduce Viral Infectivity date: 2015-03-15 words: 4960 flesch: 43 summary: Of note, no inhibitory effect was detected when 293T cells transfected to express DPP4 were chosen as targets (Figure 4B) , indicating that S protein processing in virus-producing cells might be dispensable for infectivity when target cells express robust amounts of DPP4. The coronavirus spike protein and acquisition of fusion competence Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2 Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160 Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease Furin at the cutting edge: from protein traffic to embryogenesis and disease Viral envelope glycoprotein processing by proprotein convertases DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice Comparative analysis of Ebola virus glycoprotein interactions with human and bat cells Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases Processing of the Ebola virus glycoprotein by the proprotein convertase furin The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P The biology and therapeutic targeting of the proprotein convertases Expression profiling of dipeptidyl peptidase 8 and 9 in breast and ovarian carcinoma cell lines Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry Role of proteases in the release of porcine epidemic diarrhea virus from infected cells Phenotypic analysis of mice lacking the Tmprss2-encoded protease Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines Middle East respiratory syndrome coronavirus infection in dromedary camels in saudi arabia Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion Proteolytic cleavage of the E2 glycoprotein of murine coronavirus: host-dependent differences in proteolytic cleavage and cell fusion Coronavirus IBV: partial amino terminal sequencing of spike polypeptide S2 identifies the sequence Arg-Arg-Phe-Arg-Arg at the cleavage site of the spike precursor propolypeptide of IBV strains Beaudette and M41 Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry Different host cell proteases activate the SARS-coronavirus spike-protein for cell-cell and virus-cell fusion Acknowledgments. keywords: cells; cleavage; convertases; coronavirus; cov; fusion; mers; processing; proprotein; protein; target cache: cord-317232-qk72i0gv.txt plain text: cord-317232-qk72i0gv.txt item: #324 of 515 id: cord-317389-trvleobp author: Hoy, Carlton F.O. title: Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection date: 2019-10-14 words: 4228 flesch: 41 summary: The multiplex ESPS fiber system with a housing suited for POC was introduced as a means for rapid MERS antibody detection. The bulk of this robust antibody immunoassay platform could be installed into a compact syringe-driven cassette device, which could perform multiplex antibody immunoassay for antibodies specifically against Middle East respiratory syndrome coronavirus (MERS-CoV) with rapid preparation amounting to a total of 5 min, as well as high sensitivity and specificity for the MERS-CoV down to 200 μg/mL. For the clinical use of immunoassays, these platforms are expected to be high-throughput, rapid and highly sensitive, as these are basic requirements for the necessary performance. keywords: antibodies; antibody; blocking; esps; fiber; hsa; immunoassay; mers; plasma; surface cache: cord-317389-trvleobp.txt plain text: cord-317389-trvleobp.txt item: #325 of 515 id: cord-317403-1wrsuoy7 author: Yang, Jeong-Sun title: Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015 date: 2015-11-17 words: 1477 flesch: 42 summary: An unexpected outbreak of Middle East respiratory syndrome coronavirus infection in the Republic of Korea Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea South Korea): key: cord-317403-1wrsuoy7 authors: Yang, Jeong-Sun; Park, SungHan; Kim, You-Jin; Kang, Hae Ji; Kim, Hak; Han, Young Woo; Lee, Han Saem; Kim, Dae-Won; Kim, A-Reum; Heo, Deok Rim; Kim, Joo Ae; Kim, Su Jin; Nam, Jeong-Gu; Jung, Hee-Dong; Cheong, Hyang-Min; Kim, Kisoon; Lee, Joo-Shil; Kim, Sung Soon title: Middle East Respiratory Syndrome in 3 Persons, South Korea, 2015 date: 2015-11-17 journal: Emerg Infect Dis DOI: 10.3201/eid2111.151016 sha: doc_id: 317403 cord_uid: 1wrsuoy7 In May 2015, Middle East respiratory syndrome coronavirus infection was laboratory confirmed in South Korea. keywords: cov; index; infection; mers; patient cache: cord-317403-1wrsuoy7.txt plain text: cord-317403-1wrsuoy7.txt item: #326 of 515 id: cord-317435-4yuw7jo3 author: Zhou, Yadi title: Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 date: 2020-03-16 words: 7795 flesch: 30 summary: Mesalamine induced eosinophilic pneumonia Translational high-dimensional drug interaction discovery and validation using health record databases and pharmacokinetics models MEGA X: molecular evolutionary genetics analysis across computing platforms Enrichr: a comprehensive gene set enrichment analysis web server 2016 update DrugBank 4.0: shedding new light on drug metabolism Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information ChEMBL: a large-scale bioactivity database for drug discovery BindingDB: a webaccessible database of experimentally determined protein-ligand binding affinities The IUPHAR/BPS Guide to PHARMACOLOGY: an expertdriven knowledgebase of drug targets and their ligands UniProt: the Universal Protein knowledgebase Database resources of the National Center for Biotechnology Information Conformational dynamics and allosteric regulation landscapes of germline PTEN mutations associated with autism compared to those associated with cancer Expression profile of immune response genes in patients with severe acute respiratory syndrome Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus SREBP-dependent lipidomic reprogramming as a broadspectrum antiviral target Discovery and preclinical validation of drug indications using compendia of public gene expression data This work was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) under Award Number K99 HL138272 and R00 HL138272 to F.C. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network. keywords: combinations; coronavirus; cov-2; drug; fig; gene; hcov; host; human; interactome; ncov; network; potential; proteins; sars; targets; virus cache: cord-317435-4yuw7jo3.txt plain text: cord-317435-4yuw7jo3.txt item: #327 of 515 id: cord-317647-vcktnsv8 author: Wang, Yinhua title: Assessment of the efficacy and safety of Ribavirin in treatment of coronavirus-related pneumonia (SARS, MERS and COVID-19): A protocol for systematic review and meta-analysis date: 2020-09-18 words: 1769 flesch: 46 summary: Accessed Operating characteristics of a rank correlation test for publication bias Bias in meta-analysis detected by a simple, graphical test Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds Interferon-b and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Severe acute respiratory syndrome: Report of treatment and outcome after a major outbreak Temporal patterns of hepatic dysfunction and disease severity in patients with SARS (4) IFN-a2a or IFN-b1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Medicine (2020) 99:38 www.md-journal The in vitro studies showed an antiviral effect on SARS coronavirus (SARS-CoV) and MERS coronavirus (MERS-CoV). keywords: analysis; coronavirus; ribavirin; sars; treatment cache: cord-317647-vcktnsv8.txt plain text: cord-317647-vcktnsv8.txt item: #328 of 515 id: cord-317688-mr851682 author: Oh, Myoung-don title: Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea date: 2018-02-27 words: 5576 flesch: 45 summary: respiratory syndrome coronavirus KOR/KNIH/002_05_2015, isolated in South Korea Complete genome sequence of Middle East Respiratory syndrome coronavirus (MERS-CoV) from the first imported MERS-CoV case in China Isolation of Middle East respiratory syndrome coronavirus from a patient of the 2015 Korean outbreak Microevolution of outbreak-associated Middle East respiratory syndrome coronavirus, South Korea Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombination Variations in spike glycoprotein gene of MERS-CoV Spread of mutant Middle East respiratory syndrome coronavirus with reduced affinity to human CD26 during the South Korean outbreak Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms Viral load kinetics of MERS coronavirus infection Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Kinetics of serologic responses to MERS coronavirus infection in humans Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity MERS-CoV antibody responses 1 year after symptom onset, South Korea Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Clinical implications of 5 cases of Middle East respiratory syndrome coronavirus infection in a South Korean outbreak Clinical progression and cytokine profiles of Middle East respiratory syndrome coronavirus infection Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Renal complications and their prognosis in Korean patients with Middle East respiratory syndrome-coronavirus from the central MERS-CoV designated hospital Neurological complications during treatment of Middle East respiratory syndrome Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Differential cell count and CRP level in blood as predictors for Middle East respiratory syndrome coronavirus infection in acute febrile patients during nosocomial outbreak Guidelines for the laboratory diagnosis of Middle East respiratory syndrome coronavirus in Korea Korean Society for Laboratory Medicine practice guidelines for the molecular diagnosis of Middle East respiratory syndrome during an outbreak in Korea in 2015 Importance of specimen type and quality in diagnosing Middle East respiratory syndrome An appropriate lower respiratory tract specimen is essential for diagnosis of Middle East respiratory syndrome (MERS) Atypical presentations of MERS-CoV infection in immunocompromised hosts Antiviral treatment guidelines for Middle East respiratory syndrome Predictors of mortality in Middle East respiratory syndrome (MERS) Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Real-time characterization of risks of death associated with the Middle East respiratory syndrome (MERS) in the Republic of Korea Viral RNA in blood as indicator of severe outcome in Middle East respiratory syndrome coronavirus infection Association between severity of MERS-CoV infection and incubation period MERS-CoV infection in a pregnant woman in Korea Successful treatment of suspected organizing pneumonia in a patient with Middle East respiratory syndrome coronavirus infection: a case report Mental health status of people isolated due to Middle East respiratory syndrome Possible transfusionrelated acute lung injury following convalescent plasma transfusion in a patient with Middle East respiratory syndrome Middle East respiratory syndrome infection control and prevention guideline for healthcare facilities Middle East respiratory syndrome coronavirus transmission in dialysis unit and infection control interventions in Korea Middle East respiratory syndrome clinical practice guideline for hemodialysis facilities Stability of Middle East respiratory syndrome coronavirus (MERS-246 www CoV) under different environmental conditions Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Environmental contamination and viral shedding in MERS patients Viral shedding and environmental cleaning in Middle East respiratory syndrome coronavirus infection Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS isolation wards Transmissibility of Middle East respiratory syndrome by the airborne route Nosocomial amplification of MERScoronavirus in South Korea Healthcare worker infected with Middle East Respiratory Syndrome during cardiopulmonary resuscitation in Korea Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity Seroprevalence of Middle East respiratory syndrome coronavirus among healthcare personnel caring for patients with middle east respiratory syndrome in South Korea Serologic evaluation of MERS screening strategy for healthcare personnel during a hospital-associated outbreak Middle East respiratory syndrome coronavirus transmission in dialysis unit and infection control interventions in Korea Management of asymptomatic persons who are RT-PCR positive for Middle East respiratory syndrome coronavirus (MERS-CoV): Interim guidance [Internet]. keywords: coronavirus; cov; east; hospital; infection; korea; mers; middle; outbreak; patients; syndrome; transmission cache: cord-317688-mr851682.txt plain text: cord-317688-mr851682.txt item: #329 of 515 id: cord-318181-xxc7vdnt author: Ahmed, Anwar E. title: Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia date: 2018-03-14 words: 4390 flesch: 43 summary: Accuracy and cost comparison in medical testing using sequential testing strategies Reducing cost in sequential testing: a limit of indifference approach Believe the extreme (BE) strategy at the optimal point: what strategy will it become Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study The predictors of 3-and 30-day mortality in 660 MERS-CoV patients MERS-CoV diagnosis: an update The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective study Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Laboratory testing for Middle East respiratory syndrome coronavirus (MERS-CoV) Case definition and surveillance guidance -updated Critically ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Evidence for camel-to-human transmission of MERS coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Clinical presentation and outcomes of Middle East Respiratory Syndrome in the Republic of Korea Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Combining biomarkers to detect disease with application to prostate cancer Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate MERS-CoV outbreak in Jeddah-a link to health care facilities Combining diagnostic test results to increase accuracy MERS-CoV geography and ecology in the Middle East: analyses of reported camel exposures and a preliminary risk map Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia On the principles of believe the positive and believe the negative for diagnosis using two continuous tests Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Emerging molecular markers of cancer Linear combinations of multiple diagnostic markers Comparative evaluation of three homogenization methods for isolating Middle East key: cord-318181-xxc7vdnt authors: Ahmed, Anwar E.; Al-Jahdali, Hamdan; Alshukairi, Abeer N.; Alaqeel, Mody; Siddiq, Salma S.; Alsaab, Hanan; Sakr, Ezzeldin A.; Alyahya, Hamed A.; Alandonisi, Munzir M.; Subedar, Alaa T.; Aloudah, Nouf M.; Baharoon, Salim; Alsalamah, Majid A.; Al Johani, Sameera; Alghamdi, Mohammed G. title: Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia date: 2018-03-14 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2018.03.005 sha: doc_id: 318181 cord_uid: xxc7vdnt BACKGROUND: The rapid and accurate identification of individuals who are at high risk of Middle East respiratory syndrome coronavirus (MERS-CoV) infection remains a major challenge for the medical and scientific communities. keywords: cov; infection; mers; model; patients; risk cache: cord-318181-xxc7vdnt.txt plain text: cord-318181-xxc7vdnt.txt item: #330 of 515 id: cord-318315-r6wqywwe author: Memish, Ziad A. title: Etiology of severe community-acquired pneumonia during the 2013 Hajj—part of the MERS-CoV surveillance program date: 2014-06-23 words: 3093 flesch: 45 summary: The etiology of severe pneumonia is complex and includes the newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV). Since 2012, the Saudi Ministry of Health (MoH) has required screening for MERS-CoV for all cases of severe pneumonia requiring hospitalization. keywords: cov; hajj; mers; pathogens; patients; pneumonia; samples cache: cord-318315-r6wqywwe.txt plain text: cord-318315-r6wqywwe.txt item: #331 of 515 id: cord-318448-3bkp1mtj author: Choi, Jun Yong title: An Outbreak of Middle East Respiratory Syndrome Coronavirus Infection in South Korea, 2015 date: 2015-09-01 words: 613 flesch: 44 summary: Strong infection control measures, including robust contact tracing, active surveillance, quarantine and isolation, have been applied to control the outbreak, since the initial recognition of the outbreak by the Korean government. In addition, the outbreak raised several research questions on the epidemiology, virology, pathogenesis, infection control, and treatment of MERS-CoV infection that await answering. keywords: infection; outbreak cache: cord-318448-3bkp1mtj.txt plain text: cord-318448-3bkp1mtj.txt item: #332 of 515 id: cord-318585-cp76qr9f author: Matsuyama, Ryota title: Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis date: 2016-11-29 words: 4500 flesch: 43 summary: These risks showed a substantial heterogeneity among the identified studies, and appeared to be the highest in case studies focusing on ICU cases. In ICU case studies, the expected odds ratios (OR) of death among patients with underlying heart disease or renal disease to patients without such comorbidities were 0.6 (95% Confidence Interval (CI): 0.1, 4.3) and 0.6 (95% CI: 0.0, 2.1), respectively, while the ORs were 3.8 (95% CI: 3.4, 4.2) and 2.4 (95% CI: 2.0, 2.9), respectively, in studies with other types of designs. keywords: death; east; mers; middle; risk; studies; study; syndrome cache: cord-318585-cp76qr9f.txt plain text: cord-318585-cp76qr9f.txt item: #333 of 515 id: cord-318872-0e5zjaz1 author: Park, Ji-Eun title: MERS transmission and risk factors: a systematic review date: 2018-05-02 words: 4161 flesch: 54 summary: Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Synthesizing data and models for the spread of MERS-CoV, 2013: key role of index cases and hospital transmission Identified transmission dynamics of Middle East respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department A pandemic risk assessment of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach High reproduction number of Middle East respiratory syndrome coronavirus in nosocomial outbreaks: mathematical modelling in Saudi Arabia and South Korea Accessed 10 Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea Middle East respiratory syndrome and medical students: letter from China Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Estimating the risk of Middle East respiratory syndrome (MERS) death during the course of the outbreak in the Republic of Korea Multifacility outbreak of Middle East respiratory syndrome in Taif, Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia MERS-CoV outbreak in Jeddah-a link to health care facilities Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Taking stock of the first 133 MERS coronavirus cases globally-is the epidemic changing? Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Outbreak of Middle East respiratory syndrome at tertiary care hospital Clinical and epidemiologic characteristics of spreaders of Middle East respiratory syndrome coronavirus during the 2015 outbreak in Korea Nosocomial amplification of MERS-coronavirus in South Korea Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Impact of comorbidity on fatality rate of patients with Middle East respiratory syndrome The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Spread of mutant Middle East respiratory syndrome coronavirus with reduced affinity to human CD26 during the South Korean outbreak Variations in spike glycoprotein gene of MERS-CoV Association between Australian Hajj Pilgrims' awareness of MERS-CoV, and their compliance with preventive measures and exposure to camels Factors influencing preventive behavior against Middle East respiratory syndrome-coronavirus among nursing students in South Korea Middle East respiratory syndrome-related knowledge, preventive behaviours and risk perception among nursing students during outbreak Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea the role of super-spreaders in infectious disease Super-spreaders in infectious diseases Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis Authors' contributions JEP (corresponding author) designed the study, and conducted the data search and the analysis with JEP (1st author). keywords: days; east; korea; mers; middle; south; studies; syndrome cache: cord-318872-0e5zjaz1.txt plain text: cord-318872-0e5zjaz1.txt item: #334 of 515 id: cord-318935-xsfolppr author: Yang, Jieun title: Associations Between Hand Hygiene Education and Self-Reported Hand-Washing Behaviors Among Korean Adults During MERS-CoV Outbreak date: 2018-07-16 words: 3444 flesch: 44 summary: Additionally, the effect of hand hygiene education or promotion on self-reported use of soap or hand sanitizer when washing hands was similar in individuals who lived in MERS outbreak regions and those who did not. Fifth, we could not distinguish between individuals who received hand hygiene education and those who saw promotional materials related to hand washing because the CHS questionnaire asked about both items in a single question. keywords: education; hand; self; washing cache: cord-318935-xsfolppr.txt plain text: cord-318935-xsfolppr.txt item: #335 of 515 id: cord-318954-pj5lsvsa author: Arabi, Yaseen title: Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol date: 2015-11-19 words: 3968 flesch: 43 summary: The study also has an independent data safety monitoring board (DSMB) which is responsible for reviewing reports submitted to the regarding safety of study patients, protocol adherence and may making recommendations to continue or terminate the study based on safety analysis results. Clinical and laboratory data will be collected at baseline, 30 min after first dose, 30 min after second dose, study days 1, 3, 5, 7, 14, and 28. keywords: cov; days; infection; mers; patients; plasma; study; therapy cache: cord-318954-pj5lsvsa.txt plain text: cord-318954-pj5lsvsa.txt item: #336 of 515 id: cord-319006-6f2sl0bp author: Plipat, Tanarak title: Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand, June 2015 date: 2017-08-17 words: 3964 flesch: 49 summary: [Guidelines for diagnosing and treating MERS patients, as well as protocols to prevent an outbreak in the hospital Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus: update for clinicians International Health Regulations None declared. Some passengers voluntarily reported to a hospital or health authority in response to the MOPH's announcement of first imported MERS case in Thailand. keywords: case; contacts; cov; day; east; hospital; infection; mers; patient; risk cache: cord-319006-6f2sl0bp.txt plain text: cord-319006-6f2sl0bp.txt item: #337 of 515 id: cord-319447-xanewi59 author: Sun, Jiya title: Comparative transcriptome analysis reveals the intensive early-stage responses of host cells to SARS-CoV-2 infection date: 2020-05-01 words: 3254 flesch: 40 summary: Using time-series profiling of the virus genome and host transcriptome at the same time during SARS-CoV-2 infection coupled with comparative transcriptome analysis, we found that, compared to SARS-CoV and MERS-CoV, SARS-CoV-2 induces strong host cell responses at the very early stage of infection that not only favor its high infectivity to host cells but also restrict its pathogenesis. While recent efforts have been focused on transcriptome analysis of host responses to SARS-CoV-2 infection at a certain time point in certain cell lines [5, 6] , the transcriptional dynamics of host responses to the virus infection has remained largely unexplored. keywords: cells; cov-2; figure; host; infection; mers; sars; virus cache: cord-319447-xanewi59.txt plain text: cord-319447-xanewi59.txt item: #338 of 515 id: cord-319501-a2x1hvkk author: Wong, Lok-Yin Roy title: A molecular arms race between host innate antiviral response and emerging human coronaviruses date: 2016-01-15 words: 7773 flesch: 38 summary: In a previous study, MERS-CoV M is shown to impede IFN production by preventing IRF3 translocation into the nucleus (Yang et al., 2013) . Among the five accessory proteins, ORF4a, ORF4b and ORF5 show the ability to dampen IFN production (Yang et al., 2013) . keywords: activation; coronavirus; cov; covs; et al; host; human; ifn; mers; production; proteins; rig; rna; sars; syndrome; type cache: cord-319501-a2x1hvkk.txt plain text: cord-319501-a2x1hvkk.txt item: #339 of 515 id: cord-319689-33h22ikl author: Srivastava, Sukrit title: Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach date: 2018-11-21 words: 6455 flesch: 45 summary: The conservation analysis of shortlisted 28 CTL, 28 HTL, and 12 B-cell epitopes shows that amino acid sequence conservancy of CTL epitopes varied from 72.7% to 100%, that of HTL epitopes varied from (50% for two epitopes) 68.18% to 100%, and that of B-cell epitopes varied from 85.71% to 99.26% (Tables S3, S5 , and S8). CTL epitopes were also found to have favorable molecular interaction within the cavity of transporter associated with antigen processing. keywords: analysis; cell; cov; ctl; epitopes; figure; hla; htl; mers; mevs; molecular; prediction; protein; structure cache: cord-319689-33h22ikl.txt plain text: cord-319689-33h22ikl.txt item: #340 of 515 id: cord-319707-j8y9gt2o author: Kato, Verstrepen title: Neurological manifestations of COVID-19, SARS and MERS date: 2020-06-19 words: 3562 flesch: 39 summary: The impact of SARS on epilepsy: the experience of drug withdrawal in epileptic patients Neuromuscular disorders in severe acute respiratory syndrome A major outbreak of severe acute respiratory syndrome in Hong Kong Myopathic changes associated with severe acute respiratory syndrome: a postmortem case series The neuronal death induced by endotoxic shock but not that induced by excitatory amino acids requires TNF-alpha Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain Infectious Etiologies of Rhabdomyolysis: three Case Reports and Review Rhabdomyolysis associated with probable SARS Olfactory neuropathy in severe acute respiratory syndrome: report of A case Strokes, thromboembolic events, and IVIg: rare incidents blemish an excellent safety record Large artery ischaemic stroke in severe acute respiratory syndrome (SARS) Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study Autonomic dysfunction in recovered severe acute respiratory syndrome patients Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus Neurological complications of middle east respiratory syndrome coronavirus: a report of two cases and review of the literature Neurologic syndrome due to MERS: is there a possibility that the virus can cross the blood-brain barrier to cause a neurological problem Clinical aspects and outcomes of 70 patients with middle east respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV) Pathology and pathogenesis of severe acute respiratory syndrome Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome Neurological Complications during Treatment of Middle East Respiratory Syndrome Peripheral neurotoxicity of pegylated interferon alpha. Indian journal of pediatrics Multiple organ infection and the pathogenesis of SARS Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome keywords: articles; coronavirus; covid-19; manifestations; mers; patients; sars; syndrome cache: cord-319707-j8y9gt2o.txt plain text: cord-319707-j8y9gt2o.txt item: #341 of 515 id: cord-319780-rfj9t99r author: Alexander, S.P.H. title: A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development. IUPHAR Review 29 date: 2020-05-01 words: 15233 flesch: 30 summary: A truncated version of human recombinant ACE2, lacking the transmembrane domain, mitigated against SARS-CoV infection of cells (Li et al., 2003) and has been used in animal models to reduce symptoms of severe acute lung failure , diabetic nephropathy (Oudit et al., 2010) and cardiac hypertrophy and fibrosis . It has been used to treat influenza A infection through targeting the M2 ion channel (Pinto et al., 1992; Wang et al., 1993; Holsinger et al., 1994) , although it is no longer recommended in the UK or US because of drug resistance (for review, see Li et al., 2015) . keywords: ace2; activity; acute; angiotensin; binding; cells; converting; coronavirus; cov-2; covid-19; domain; drug; entry; enzyme; et al; host; human; infection; inhibitors; interferon; membrane; mers; protease; protein; receptor; replication; review; rna; sars; sars coronavirus; spike; structure; syndrome; target; tmprss2 cache: cord-319780-rfj9t99r.txt plain text: cord-319780-rfj9t99r.txt item: #342 of 515 id: cord-319784-lpmsalux author: Alqahtani, Amani S. title: Pilot use of a novel smartphone application to track traveller health behaviour and collect infectious disease data during a mass gathering: Hajj pilgrimage 2014 date: 2015-08-13 words: 3511 flesch: 48 summary: The case for effective post-Hajj surveillance for infection Evidence for camel-to-human transmission of MERS coronavirus New digital technologies for the surveillance of infectious diseases at mass gathering events Hospital electronic medical recordbased public health surveillance system deployed during the 2002 Winter Olympic Games Illness and injury in athletes during the competition period at the London 2012 Paralympic games: development and implementation of a web-based surveillance system (WEB-IISS) for team medical staff Causes of mortality for Indonesian Hajj Pilgrims: comparison between routine death certificate and verbal autopsy findings Digital Industry Association for Australia. In order to reduce the risk of ARI among Hajj pilgrims, the Saudi Arabian health authority recommends a range of infection control measures [4] , however, compliance to these measures is highly variable keywords: app; data; hajj; health; participants; pilgrims; questionnaire; study cache: cord-319784-lpmsalux.txt plain text: cord-319784-lpmsalux.txt item: #343 of 515 id: cord-319877-izn315hb author: de Wit, Emmie title: SARS and MERS: recent insights into emerging coronaviruses date: 2016-06-27 words: 9406 flesch: 31 summary: Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage A two-pronged strategy to suppress host protein synthesis by SARS coronavirus nsp1 protein Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain Middle East respiratory syndrome coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of cytoplasmic origin Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists MAVS-mediated apoptosis and its inhibition by viral proteins Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses Mechanisms of action of ribavirin against distinct viruses Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical analysis of the first patient with imported Middle East respiratory syndrome in China Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Identification of severe acute respiratory syndrome in Canada Development of a standard treatment protocol for severe acute respiratory syndrome A cluster of cases of severe acute respiratory syndrome in Hong Kong Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques The first application of a potential treatment option for MERS through the repurposing of IFNα2b and ribavirin in a non-human primate model Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Combination therapy with lopinavir/ ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report Clinical implications of five cases of Middle East respiratory syndrome coronavirus infection in South Korea Outbreak From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design Thiopurine analogs and mycophenolic acid synergistically inhibit the papainlike protease of Middle East respiratory syndrome coronavirus Ligand-induced dimerization of Middle East respiratory syndrome (MERS) coronavirus nsp5 protease (3CL pro ): implications for nsp5 regulation and the development of antivirals Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture International Severe Acute Respiratory & Emerging Infection Consortium. WHO Nidovirus transcription: how to make sense…? Coronaviruses post-SARS: update on replication and pathogenesis Coronaviruses: an overview of their replication and pathogenesis SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage Infidelity of SARS-CoV nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS Middle East respiratory syndrome coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Evidence for camel-to-human transmission of MERS coronavirus MERS coronavirus in dromedary camel herd, Saudi Arabia Isolation of MERS coronavirus from a dromedary camel Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study An analysis of the predominant role for nosocomial transmission in the epidemiology of both SARS and MERS Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study A description of the clinical representation of SARS-CoV respiratory disease in patients from Hong Kong Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Evidence that infectious MERS-CoV can be detected on common hospital surfaces during an outbreak, which highlights the potential for nosocomial transmission and stresses the need for infection control The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Middle East respiratory syndrome coronavirus superspreading event involving 81 persons the role of super-spreaders in infectious disease Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Biomarkers in acute respiratory distress syndrome The mercurial nature of neutrophils: still an enigma in ARDS? SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Genome wide identification of SARS-CoV susceptibility loci using the Collaborative Cross Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV Rapid generation of a mouse model for Middle East respiratory syndrome A study in which the DPP4-based host restriction is overcome in mice by expression of the human variant of DPP4, leading to the development of several transgenic mouse models MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex keywords: coronavirus; cov; east; host; human; infection; mers; middle; patients; protein; replication; respiratory; ribavirin; sars; syndrome; syndrome coronavirus; transmission; treatment cache: cord-319877-izn315hb.txt plain text: cord-319877-izn315hb.txt item: #344 of 515 id: cord-320238-qbjrlog1 author: Okba, Nisreen M. A. title: Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV date: 2020-05-29 words: 6205 flesch: 43 summary: Furthermore, using a SypTag/SpyCatcher system and LS particles, we tested whether immune focusing with/ without multivalent presentation of the viral RBD can lead to enhanced protection against a MERS-CoV challenge in rabbits. Using this approach, we found no significant increase in anti-scaffold antibody responses compared to the homologous prime-boost scheme ( Figure 4C ). keywords: antibodies; antibody; cov; expression; figure; immune; mers; protein; rabbits; rbd; responses; vaccine; virus cache: cord-320238-qbjrlog1.txt plain text: cord-320238-qbjrlog1.txt item: #345 of 515 id: cord-320548-oigyut2k author: Zumla, Alimuddin title: Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options date: 2014-09-01 words: 8128 flesch: 22 summary: A antibodies Antiviral combinations for severe infl uenza infections: a review Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant infl uenza virus strains in vitro Effi cacy of oseltamivirzanamivir combination compared to each monotherapy for seasonal infl uenza: a randomized placebo-controlled trial Triple-combination antiviral drug for pandemic H1N1 infl uenza virus infection in critically ill patients on mechanical ventilation Adjuvant treatment with a mammalian target of rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute respiratory failure Anti-malaria drug chloroquine is highly eff ective in treating avian infl uenza A H5N1 virus infection in an animal model Eff ectiveness of chloroquine against infl uenza Chloroquine for infl uenza prevention: a randomised, double-blind, placebo controlled trial International Severe Acute Respiratory and Emerging Infections Consortium Treatment of MERS-CoV: information for clinicians. Romark announces clinical trial results for new infl uenza drug presented at IDSA meeting Eff ect of nitazoxanide in adults and adolescents with acute uncomplicated infl uenza: a double-blind, randomised, placebo-controlled, phase 2b/3 trial Adjunctive therapies and immunomodulatory agents in the management of severe infl uenza The eff ectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral aetiology: a systematic review and exploratory meta-analysis Convalescent plasma treatment reduced mortality in patients with severe pandemic infl uenza A (H1N1) 2009 virus infection Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 infl uenza A(H1N1) infection An in vivo human-plasmablast enrichment technique allows rapid identifi cation of therapeutic infl uenza keywords: antiviral; cells; clinical; drug; eff; infections; infl; infl uenza; oseltamivir; patients; resistance; respiratory; therapy; treatment; trial; tuberculosis; uenza; use; viral; virus cache: cord-320548-oigyut2k.txt plain text: cord-320548-oigyut2k.txt item: #346 of 515 id: cord-320663-xypg6evo author: Market, Marisa title: Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies date: 2020-06-23 words: 14058 flesch: 29 summary: A natural killer cell receptor for HLA-B allotypes Molecular clones of the p58 NK cell receptor reveal immunoglobulinrelated molecules with diversity in both the extra-and intracellular domains HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b) TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection Human NK cells and herpesviruses: mechanisms of recognition, response and adaptation Cytokine regulation of natural killer cell effector functions Coordinated and distinct roles for IFN-αβ, IL-12, and IL-15 regulation of NK cell responses to viral infection Developmental and functional control of natural killer cells by cytokines. Despite their vital role in viral infection, the contribution of NK cells in fighting SARS-CoV-2 has not yet been directly investigated. keywords: acute; cancer; cells; coronavirus; cov-2; covid-19; cytokine; disease; human; ifn; immune; infection; killer; levels; mers; nk cells; patients; respiratory; response; role; sars; studies; syndrome; therapy; type cache: cord-320663-xypg6evo.txt plain text: cord-320663-xypg6evo.txt item: #347 of 515 id: cord-320709-2pnqpljt author: Munster, Vincent J. title: Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) date: 2016-02-22 words: 3954 flesch: 42 summary: In vitro, the MERS-CoV spike glycoprotein interacted with Jamaican fruit bat (Artibeus jamaicensis) dipeptidyl peptidase 4 (DPP4) receptor and MERS-CoV replicated efficiently in Jamaican fruit bat cells, suggesting there is no restriction at the receptor or cellular level for MERS-CoV. MERS-CoV replicated efficiently to high titers in both cell lines (Fig. 1B) , indicating that there is no restriction at the receptor or cellular level for MERS-CoV replication in Jamaican fruit bat cells. keywords: bats; cells; coronavirus; cov; dpi; fruit; mers; middle; respiratory; syndrome cache: cord-320709-2pnqpljt.txt plain text: cord-320709-2pnqpljt.txt item: #348 of 515 id: cord-320746-iuzfexig author: Rasmussen, Sonja A. title: Middle East Respiratory Syndrome Coronavirus: Update for Clinicians date: 2015-02-20 words: 2391 flesch: 37 summary: Coronavirus infections-disease oubreak news Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Middle East respiratory syndrome coronavirus disease in children State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Enhanced MERS coronavirus surveillance of travelers from the Middle East to England Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Middle East respiratory syndrome (MERS): information for health providers Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus An observational, laboratorybased study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus: implications for health care facilities Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus infections in health care workers Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Acknowledgments. keywords: cases; coronavirus; cov; east; mers; syndrome cache: cord-320746-iuzfexig.txt plain text: cord-320746-iuzfexig.txt item: #349 of 515 id: cord-320909-p93gxjm2 author: Natoli, S. title: Does SARS‐Cov‐2 invade the brain? Translational lessons from animal models date: 2020-05-22 words: 4730 flesch: 33 summary: Radiology 2020 Neurological manifestations of hospitalized patients with Coronavirus Disease Labs rush to study coronavirus in transgenic animals -some are in short supply A novel coronavirus associated with severe acute respiratory syndrome Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome Possible central nervous system infection by SARS coronavirus Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: Implications for pathogenesis virus transmission pathways Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. In line with observations in SARS models, non-human primates and wild-type mice infected with SARS-CoV-2 exhibit a relatively mild clinical disease, in spite of the evidence that Quantitative reverse transcription polymerase chain reaction (RT-qPCR) revealed a massive infection of the respiratory tract [44, 45] (Table 2) . keywords: brain; coronavirus; cov; cov-2; human; infection; mers; mice; models; sars; syndrome cache: cord-320909-p93gxjm2.txt plain text: cord-320909-p93gxjm2.txt item: #350 of 515 id: cord-320921-eumuid3r author: Widagdo, W. title: Lack of Middle East Respiratory Syndrome Coronavirus Transmission in Rabbits date: 2019-04-24 words: 4834 flesch: 47 summary: Using immunohistochemistry, we analyzed the DPP4 expression in rabbit respiratory tract tissues. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Geographic distribution of MERS coronavirus among dromedary camels Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation Reported Direct and Indirect Contact with Dromedary Camels among Laboratory-Confirmed MERS-CoV Cases Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus Middle East respiratory syndrome coronavirus specific antibodies in naturally exposed Israeli llamas, alpacas and camels Infection, Replication, and Transmission of Middle East Respiratory Syndrome Coronavirus in Alpacas Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Airborne transmission of influenza A/H5N1 virus between ferrets New case-Qatari Supreme Council of Health Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Deletion Variants of Middle East Respiratory Syndrome Coronavirus from Humans Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: keywords: cov; mers; nasal; rabbits; swabs; transmission; viral; virus cache: cord-320921-eumuid3r.txt plain text: cord-320921-eumuid3r.txt item: #351 of 515 id: cord-320928-flsaa1wx author: Aldohyan, Meshal title: The perceived effectiveness of MERS-CoV educational programs and knowledge transfer among primary healthcare workers: a cross-sectional survey date: 2019-03-21 words: 5010 flesch: 44 summary: Mayo Clinic Implementing knowledge management practices in hospital-in-the-home units The role of advanced practice nurses in knowledge brokering as a means of promoting evidence-based practice among clinical nurses Knowledge, attitude, and practice toward MERS-CoV among primary health-care workers in Makkah Al-Mukarramah: an intervention study Knowledge and perception of health practitioners towards MERS-CoV in hail region, Kingdom of Saudi Arabia Knowledge and attitude towards the Middle East respiratory syndrome coronavirus among healthcare personnel in the southern region of Saudi Arabia Knowledge, attitudes and Behaviours of healthcare Workers in the Kingdom of Saudi Arabia to MERS coronavirus and other emerging infectious diseases Sense making and knowledge transfer: capturing the knowledge and wisdom of nursing leaders Nurses' participation in personal knowledge transfer: the role of leader-member exchange (LMX) and structural empowerment Knowledge communication: a key to successful crisis management L'accréditation, source de connaissance et d'enrichissement Using interactive workshops to prompt knowledge exchange: a realist evaluation of a knowledge to action initiative Culture as an issue in knowledge sharing: a means of competitive advantage academic conferences limited Understanding change and change management processes: a case study An educational programme for nursing college staff and students during a MERS-coronavirus outbreak in Saudi Arabia Questionnaire-based analysis of infection prevention and control in healthcare facilities in Saudi Arabia in regards to Middle East respiratory syndrome Middle East respiratory syndrome-related knowledge, preventive behaviours and risk perception among nursing students during outbreak Intra-firm knowledge transfer-a qualitative case study of knowledge transfer and its implications in a soft service firm Knowledge management practices in healthcare settings: a systematic review The importance of knowledge transfer between specialist and generic services in improving health care: a cross-national study of dementia care in England and the Netherlands Diffusion of Innovations Impaired memory retrieval correlates with individual differences in cortisol response but not autonomic response Expatriate knowledge transfer, subsidiary absorptive capacity, and subsidiary performance key: cord-320928-flsaa1wx authors: Aldohyan, Meshal; Al-Rawashdeh, Nedal; Sakr, Farouk M.; Rahman, Saeed; Alfarhan, Ali I.; Salam, Mahmoud title: The perceived effectiveness of MERS-CoV educational programs and knowledge transfer among primary healthcare workers: a cross-sectional survey date: 2019-03-21 journal: BMC Infect Dis DOI: 10.1186/s12879-019-3898-2 sha: doc_id: 320928 cord_uid: flsaa1wx BACKGROUND: Knowledge transfer of Middle East respiratory syndrome coronavirus (MERS-CoV) involves the dissemination of created/acquired information on MERS-CoV in hospitals, making this information accessible to all healthcare workers (HCWs). keywords: arabia; cov; hcws; knowledge; mers; perception; programs; saudi; study; transfer cache: cord-320928-flsaa1wx.txt plain text: cord-320928-flsaa1wx.txt item: #352 of 515 id: cord-321080-pgxxkfc0 author: Wang, Cong title: Combining a Fusion Inhibitory Peptide Targeting the MERS-CoV S2 Protein HR1 Domain and a Neutralizing Antibody Specific for the S1 Protein Receptor-Binding Domain (RBD) Showed Potent Synergism against Pseudotyped MERS-CoV with or without Mutations in RBD date: 2019-01-06 words: 4578 flesch: 40 summary: However, we herein report that the combination of m336 and HR2P-M2 exhibited potent synergism in inhibiting MERS-CoV S protein-mediated cell–cell fusion and infection by MERS-CoV pseudoviruses with or without mutations in the RBD, resulting in the enhancement of antiviral activity in contrast to either one administered alone. In the present study, the sensitivity of pseudotyped MERS-CoV strains with key mutations in RBD, as identified in some MERS-CoV mutants isolated during the 2012-2015 outbreaks [17] , including D509G, D510G, Q522H, and I529T, along with wild-type MERS-CoV, was compared between the inhibitory activity of HR2P-M2 peptide alone and m336 neutralizing mAb alone. keywords: cell; combination; cov; hr2p; m336; mers; protein cache: cord-321080-pgxxkfc0.txt plain text: cord-321080-pgxxkfc0.txt item: #353 of 515 id: cord-321131-f8qeytxc author: Zhou, Yanchen title: Protease inhibitors targeting coronavirus and filovirus entry date: 2015-04-30 words: 5550 flesch: 38 summary: Experiments were therefore repeated at higher doses of cysteine protease inhibitor (50 mg/kg), either alone or in combination with the serine protease inhibitor, camostat (30 mg/kg) (Fig. 3) . Camostat displayed antiviral activity in a pathogenic animal model for SARS-CoV infection, indicating that serine protease inhibitors are suitable for treatment of SARS and potentially MERS. keywords: camostat; cells; coronavirus; cov; cysteine; entry; inhibitors; k11777; proteases; sars; serine; virus cache: cord-321131-f8qeytxc.txt plain text: cord-321131-f8qeytxc.txt item: #354 of 515 id: cord-321185-kj67rd7g author: Eckerle, Isabella title: Replicative Capacity of MERS Coronavirus in Livestock Cell Lines date: 2014-02-17 words: 1477 flesch: 37 summary: In addition to livestock cell lines, we used rodent, insectivore, bat, and primate cell lines in the experiments (Table) . 321185 cord_uid: kj67rd7g Replicative capacity of Middle East respiratory syndrome coronavirus (MERS-CoV) was assessed in cell lines derived from livestock and peridomestic small mammals on the Arabian Peninsula. keywords: cells; cov; lines; mers; virus cache: cord-321185-kj67rd7g.txt plain text: cord-321185-kj67rd7g.txt item: #355 of 515 id: cord-321259-wio2b49i author: Carmona-Gutierrez, Didac title: Digesting the crisis: autophagy and coronaviruses date: 2020-05-04 words: 4365 flesch: 26 summary: lifespan extension by the natural polyamine spermidine Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes Polyamines and Their Role in Virus Infection Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation Pathogen recognition and innate immunity Autophagy Promotes MHC Class II Presentation of Peptides from Intracellular Source Proteins Autophagy Beyond Intracellular MHC Class II Antigen Presentation Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection The relationship between autophagy and the immune system and its applications for tumor immunotherapy Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance Autophagy is a critical regulator of memory CD8+ T cell formation Polyamines Control eIF5A Autophagy and inflammasomes Secretory autophagy Human placental trophoblasts confer viral resistance to recipient cells Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection A discovery platform for the identification of caloric restriction mimetics with broad health-improving effects Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential Given the devastating consequences of the current COVID-19 pandemic, the question arises whether manipulating autophagy might be an expedient approach to fight the novel coronavirus SARS-CoV-2. keywords: autophagy; cell; chloroquine; coronavirus; covid-19; covs; disease; effects; induction; infection; replication; sars; spermidine cache: cord-321259-wio2b49i.txt plain text: cord-321259-wio2b49i.txt item: #356 of 515 id: cord-321260-oi37dfsp author: Ahmed, Anwar E. title: Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study date: 2017-12-22 words: 3069 flesch: 52 summary: The authors of all previously published studies of MERS-CoV were not able to assess survival rate in MERS cases from various countries that were reported to the World Health Organization (WHO). This study aimed to assess how region, patient and disease characteristics influence 14- and 45-day mortality in MERS patients. keywords: mers; mortality; patients; study; survival cache: cord-321260-oi37dfsp.txt plain text: cord-321260-oi37dfsp.txt item: #357 of 515 id: cord-321651-7e8dwcur author: Jazieh, Abdul-Rahman title: Managing Oncology Services During a Major Coronavirus Outbreak: Lessons From the Saudi Arabia Experience date: 2020-03-27 words: 2728 flesch: 44 summary: Patients were transported via hospital ambulance if their condition was unstable; patients in stable condition were transferred by private car. The main objectives of this committee were to communicate to the oncology department staff the information received from the daily Hospital Command Center meetings, discuss the current status of the outbreak in the whole hospital, and assess the risk for oncology patients. keywords: cancer; care; infection; oncology; patients; plan; staff cache: cord-321651-7e8dwcur.txt plain text: cord-321651-7e8dwcur.txt item: #358 of 515 id: cord-321800-0h28pg3b author: Klingelhöfer, Doris title: Coronavirus: An insight into global research until outbreak of COVID-19 and its implications for the future date: 2020-09-23 words: 6123 flesch: 51 summary: During this period, the affected nations seem to have created an awareness of the importance of SARS research and the international interest in CoV research that responds to it. The financing of CoV research is also picking up speed. keywords: articles; cases; countries; cov; mers; number; publication; research; sars cache: cord-321800-0h28pg3b.txt plain text: cord-321800-0h28pg3b.txt item: #359 of 515 id: cord-321851-ku4z34lu author: Alosaimi, Bandar title: MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract date: 2020-02-29 words: 5630 flesch: 38 summary: CD4 + T-cell immune responses during respiratory viral infections characterized by the production of signature cytokines, IFN-γ, TNF-α, and IL-2 for Th1 cells and IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13 for Th2 cells IL-1β has been associated with tissue damage, neutrophil infiltration, acute inflammatory responses, higher case fatality and severe respiratory viral infection [10, 14, 19, 49, 50] . keywords: chemokines; cov; cytokines; expression; immune; infection; levels; mers; patients; th1; th2; viral cache: cord-321851-ku4z34lu.txt plain text: cord-321851-ku4z34lu.txt item: #360 of 515 id: cord-321918-9jwma2y6 author: Xiu, Siyu title: Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities date: 2020-06-15 words: 10551 flesch: 42 summary: Hypertension A novel angiotensin-converting enzyme−related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1−9 Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Screening and identification of linear B-cell epitopes and entry-blocking peptide of severe acute respiratory syndrome (SARS)-associated coronavirus using synthetic overlapping peptide library A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2 Using peptidomimetics and constrained peptides as valuable tools for inhibiting protein−protein interactions Novel peptide inhibitors of angiotensin-converting enzyme 2 Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in Vitro Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Chronic hydroxychloroquine use associated with qt prolongation and refractory ventricular arrhythmia Conduction disorder and qt prolongation secondary to long-term treatment with chloroquine Chloroquine and hydroxychloroquine retinopathy-related risk factors in a turkish cohort Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2) TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds ACE2 X-ray structures reveal a large hingebending motion important for inhibitor binding and catalysis Szczubialka, K. Novel polymeric inhibitors of HCoV-NL63 HTCC: broad range inhibitor of coronavirus entry Angiotensin-converting enzyme 2 protects from severe acute lung failure The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice Cell-based antiviral screening against coronaviruses: developing virus-specific and broad-spectrum inhibitors Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein Inhibition of human coronavirus NL63 infection at early stages of the replication cycle Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): in search of potent SARS-CoV entry inhibitors Protective effect of intranasal regimens containing peptidic middle east respiratory syndrome coronavirus fusion inhibitor against mers-cov infection A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion Identification of a novel inhibitor against Middle East respiratory syndrome coronavirus Peptide-based membrane fusion inhibitors targeting hcov-229e spike protein HR1 and HR2 domains SARS-CoV-2) based on SARS-CoV immunological studies Fully human monoclonal antibody directed to proteolytic cleavage site in severe acute respiratory syndrome (SARS) Situation Reports; World Health Organization COVID-19) Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted SARS coronavirus entry into host cells through a novel clathrin-and caveolae-independent endocytic pathway Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step Coronavirus cell entry occurs through the endo-/ lysosomal pathway in a proteolysis-dependent manner Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2 SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion Identification and characterization of the putative fusion peptide of the severe acute respiratory syndrome-associated coronavirus spike protein Drug targets for corona virus: a systematic review Mouse hepatitis virus type 2 enters cells through a clathrin-mediated endocytic pathway independent of eps15 A decade after SARS: strategies for controlling emerging coronaviruses Severe Acute Respiratory Syndrome Coronavirus 2 Isolate Wuhan-Hu-1 A new coronavirus associated with human respiratory disease in China Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2 Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV Pathology and pathogenesis of severe acute respiratory syndrome Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: an in silico analysis Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction Identification of critical determinants on ACE2 for SARS-CoV entry and development of a potent entry inhibitor Faccin-Galhardi, L. C. Antibody therapy for the control of viral diseases: an update Monoclonal antibodies for prophylaxis and therapy of infectious diseases. keywords: ace2; cells; coronavirus; cov; cov-2; entry; fusion; human; infection; inhibitors; mers; peptide; protein; receptor; sars; spike; syndrome; value cache: cord-321918-9jwma2y6.txt plain text: cord-321918-9jwma2y6.txt item: #361 of 515 id: cord-322354-x61eqaca author: Young Lee, Jun title: Identification of 4-Anilino-6-aminoquinazoline Derivatives as Potential MERS-CoV Inhibitors date: 2020-08-08 words: 615 flesch: 56 summary: [1] [2] [3] In 2003, one of the novel coronaviruses, severe acute respiratory syndrome CoV (SARS-CoV), caused a total of 8,422 cases of SARS with 916 deaths. The other novel coronavirus, Middle East respiratory syndrome CoV (MERS-CoV), has emerged in April 2012 and posed a serious threat to public health. keywords: cov; infection; mers cache: cord-322354-x61eqaca.txt plain text: cord-322354-x61eqaca.txt item: #362 of 515 id: cord-322760-tsxniu3j author: Sha, Jianping title: Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea date: 2016-09-23 words: 4632 flesch: 53 summary: [17] [18] [19] vs. 9 days [0-24], p = 0.041) and in sporadic MERS cases (12 days vs. 9 days [0-30], p = 0.003). These findings can be attributed to three facts: first, the majority of HCP developed asymptomatic or mild symptoms and moderate symptoms [15] ; second, HCP were confirmed as secondary cases under medical investigation, which led to earlier confirmation and good outcomes [32] ; third, epidemiological analysis showed that HCP were much younger and had fewer co-morbidities compared to total MERS cases [36] . keywords: cases; cov; east; korea; mers; middle; outbreaks; syndrome cache: cord-322760-tsxniu3j.txt plain text: cord-322760-tsxniu3j.txt item: #363 of 515 id: cord-323087-3cxyogor author: Widagdo, W. title: Tissue Distribution of the MERS-Coronavirus Receptor in Bats date: 2017-04-26 words: 3431 flesch: 41 summary: The antibody used in this study recognizes bat DPP4 as was demonstrated in transfection experiments using cloned Pipistrelle bat DPP4 22 . Middle East respiratory syndrome An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Antibodies against MERS coronavirus in dromedary camels Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection Replicative Capacity of MERS Coronavirus in Livestock Cell Lines Circulation of group 2 coronaviruses in a bat species common to urban areas in Western Europe Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Close relative of human Middle East respiratory syndrome coronavirus in bat Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe MERS-related betacoronavirus in Vespertilio superans bats Group C betacoronavirus in bat guano fertilizer Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans keywords: bat; bats; cells; cov; dpp4; fruit; mers; respiratory cache: cord-323087-3cxyogor.txt plain text: cord-323087-3cxyogor.txt item: #364 of 515 id: cord-323093-u3ozc9ry author: Rathnayake, Athri D. title: 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice date: 2020-08-19 words: 7178 flesch: 48 summary: In the presence of compound concentrations that were about two-to threefold higher than the EC 50 values obtained in Vero E6 cells (2 M, 6j or 0.5 M, 6e), viral titers were reduced to 10 6.4 (donor 1), 10 6.1 (donor 2), and 10 6.3 (donor 3) PFU/ml for compound 6j or 10 6.1 (donor 1), 10 6.5 (donor 2), and 10 8.1 (donor 3) PFU/ml for compound 6e (Table 3) . Compounds 6j and 6h share a near-identical structure except for the extra methylene group present in compound 6j. keywords: 3clpro; cells; compound; coronavirus; cov; cov-2; dpi; fig; inhibitors; mers; mice; protease; sars; table cache: cord-323093-u3ozc9ry.txt plain text: cord-323093-u3ozc9ry.txt item: #365 of 515 id: cord-323125-qtlevnbt author: Al Hosani, Farida Ismail title: Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates date: 2019-02-01 words: 3710 flesch: 42 summary: Data collected included demographics; residence/household description; exposure history to other MERS-CoV cases, healthcare settings, and animals; travel history; and medical history, including any long-term effects reported by case patients. Females comprised a higher proportion of case patients compared with household contacts (70.6% vs 53.2%), and case patients were older compared with household contacts (median, 42 years vs 31 years). keywords: case; contacts; coronavirus; cov; household; investigation; mers; patients; respiratory; transmission cache: cord-323125-qtlevnbt.txt plain text: cord-323125-qtlevnbt.txt item: #366 of 515 id: cord-323428-jd91k19z author: Ababneh, Mustafa title: Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice date: 2019-10-11 words: 5739 flesch: 45 summary: Emergence of a novel human coronavirus Middle East respiratory syndrome coronavirus MERS-CoV: Current knowledge gaps Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans MERS-CoV--are we on the verge of a pandemic? Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation Antibodies against MERS coronavirus in dromedary camels Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus Type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant modified vaccinia virus ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th 1 and Th 2 responses against Middle East respiratory syndrome coronavirus Distribution and absence of generalized lesions in mice following single-dose intramuscular inoculation of the vaccine candidate MVA-MERS-S Immunogenicity of different forms of Middle East respiratory syndrome s glycoprotein ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC The receptor-binding domain of MERS-CoV: The dawn of vaccine and treatment development Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats Available at www.veterinaryworld.org Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus The Gene Delivery Company): Recombinant Adenovirus Construction Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Endogenous biotin expression in renal and testicular tumors and literature review Retrieved endogenous biotin: S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime. keywords: coronavirus; cov; group; mers; production; protein; response; specific; vaccinated; vaccine cache: cord-323428-jd91k19z.txt plain text: cord-323428-jd91k19z.txt item: #367 of 515 id: cord-323533-otosnjde author: Ekins, Sean title: Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses date: 2020-04-21 words: 1115 flesch: 43 summary: Virus, normally at 50% cell culture infectious doses (CCID 50 ) in an 0.1-ml volume, was placed in those wells designated for virus infection (CHIK, 10 CCID 50 into 4e 4 cells per well ϭ multiplicity of infection [MOI] of 0.0003, and MERS-CoV, 132 CCID 50 into 2e 4 cells per well ϭ MOI of 0.007). Tilorone was tested (using the NIAID DMID services) against representatives of the Herpesviridae, Bunyaviridae, Togaviridae, Arenaviridae, Flaviviridae, Picornaviridae, and Poxviridae; hepatic viruses; respiratory viruses; and other viruses. keywords: antiviral; tilorone; virus; viruses cache: cord-323533-otosnjde.txt plain text: cord-323533-otosnjde.txt item: #368 of 515 id: cord-324106-unvycvx4 author: Ki, Hyun Kyun title: Risk of transmission via medical employees and importance of routine infection-prevention policy in a nosocomial outbreak of Middle East respiratory syndrome (MERS): a descriptive analysis from a tertiary care hospital in South Korea date: 2019-10-30 words: 6412 flesch: 53 summary: But it should be extended to all people treated by any medical employee who has contact with MERS patients. This patient and caregivers denied any possibility of contact with MERS patients. keywords: contact; hospital; index; index patient; mers; patient; people; risk; transmission cache: cord-324106-unvycvx4.txt plain text: cord-324106-unvycvx4.txt item: #369 of 515 id: cord-324165-afdmsbw2 author: Joo, Heesoo title: The effects of past SARS experience and proximity on declines in numbers of travelers to the Republic of Korea during the 2015 MERS outbreak: A retrospective study date: 2019-08-31 words: 5126 flesch: 51 summary: Press releases: government removes red Outbound travel alert for Korea Hong Kong issues 'red alert' against South Korea travel due to MERS Travel warnings to the Republic of Korea due to the MERS outbreak from all foreign countries are lifted: response activities, achievements, and future plans for the MERS outbreak from Ministry of Foreign Affairs Airlines cut flights to South Korea as China steps up MERS alert In light of current MERS-CoV outbreak in South Korea, Taiwan CDC issues travel notice level for Seoul to Level 2: alert for MERS-CoV and plans five major response strategies Travel notice of Level 2: alert for MERS-CoV to entire South Korea issued in response to growing MERS outbreak in South Korea; Public urged to avoid unnecessary hospital visits in South Korea Taiwan CDC lowers travel notice level for South Korea to Level 1: watch for MERS and advises travelers visiting China to take precautions against tick bites Taiwan CDC removes MERS travel notice for South Korea and Bhrain as outbreak in South Korea brought under control Foreign ministry raises travel advisory for Seoul Test results of Taipei suspected MERS-CoV case came back negative Countries' response to WHO's travel recommendations during the 2013-2016 Ebola outbreak Prevention and control guideline for Middle East respiratory synderome coronavirus Surveillance and public health response for travelers returning from MERS-CoV affected countries to Gyeonggi Province Statutes of the Republic of Korea, quarantine act, chapter I general provisions, article 2 (definition) Coordinated response to SARS Appendix Fig. 3 . Since the 2015 MERS outbreak ended, the ROK government has continuously made efforts to prevent future MERS outbreaks in the ROK. keywords: areas; arrivals; cases; mers; outbreak; rok; sars; travel cache: cord-324165-afdmsbw2.txt plain text: cord-324165-afdmsbw2.txt item: #370 of 515 id: cord-324324-8ybfiz8f author: Decaro, Nicola title: Novel human coronavirus (SARS-CoV-2): A lesson from animal coronaviruses date: 2020-04-14 words: 14950 flesch: 34 summary: After 2002-2003 SARS epidemic, the renovated interest in HCoVs allowed the discovery of two additional viruses, the alphacoronavirus HCoV-NL63 and the betacoronavirus HCoV-HKU1, derived from bats and rodents, respectively (Tao et al., 2017) . NL63 (Tao et al., 2017) . keywords: animals; avian; bats; betacoronavirus; canine; ccov; china; coronavirus; cov; cov-2; covs; disease; enteric; et al; gene; genome; genus; host; human; ibv; infection; mers; novel; origin; protein; recombination; sars; species; strains; subgenus; syndrome; viruses; wild cache: cord-324324-8ybfiz8f.txt plain text: cord-324324-8ybfiz8f.txt item: #371 of 515 id: cord-324671-7xdnmms9 author: Seo, Yae Eun title: Factors Associated with Burnout among Healthcare Workers during an Outbreak of MERS date: 2020-07-08 words: 2923 flesch: 46 summary: Kim and Choi 13 examined burnout after MERS in terms of job stress caused by MERS, fear of MERS infection, hospital resources for the treatment of MERS, and support from family and friends. For example, workers with repeated indirect traumatic experiences are more likely to experience burnout, and thus the identification and treatment of individuals with traumatic work experience may be effective for reducing future burnout in HCWs. keywords: burnout; hcws; job; mers; outbreak; risk cache: cord-324671-7xdnmms9.txt plain text: cord-324671-7xdnmms9.txt item: #372 of 515 id: cord-324926-3c5ab73l author: Xia, Shuai title: A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike date: 2019-04-10 words: 10963 flesch: 48 summary: To investigate the structural basis for the pan-CoV inhibitory effect of EK1 peptide, we crystallized EK1 in complex with HR1 peptides from three representative HCoVs, including the most pathogenic SARS-CoV and MERS-CoV in -HCoVs and 229E in -HCoVs, the HR1 of which is 14 amino acids longer than those of -HCoVs. The coding sequence of EK1 peptide was individually fused to the 3′ end of the HR1 domain from SARS-CoV, MERS-CoV, and HCoV-229E (residues 892 to 970, 984 to 1062, and 785 to 873, respectively) through a six-amino acid linker (L6: SGGRGG). keywords: activity; cell; coronavirus; cov; ek1; fig; fusion; hcovs; hr1; hr2; hr2p; human; infection; inhibitory; mers; mice; oc43; peptide; protein; residues; sars cache: cord-324926-3c5ab73l.txt plain text: cord-324926-3c5ab73l.txt item: #373 of 515 id: cord-324978-9qfhsj3n author: Alagaili, Abdulaziz N. title: Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia date: 2014-02-25 words: 3573 flesch: 46 summary: These limitations notwithstanding, the most urgent public health concern, raised in work we and others have reported that focuses on DC infection, is to determine the role of these animals in sporadic human infection. The only archived DC specimens we have been able to locate are DC sera; our efforts to recover MERS-CoV sequences from camel blood have been unsuccessful. keywords: coronavirus; cov; east; human; mers; nasal; samples; sequences; swabs cache: cord-324978-9qfhsj3n.txt plain text: cord-324978-9qfhsj3n.txt item: #374 of 515 id: cord-325261-bdumhy5b author: Clemente, Valentino title: Deubiquitinating Enzymes in Coronaviruses and Possible Therapeutic Opportunities for COVID-19 date: 2020-05-15 words: 7830 flesch: 38 summary: ROS/p38 MAPK/STAT3 pathway SARS coronavirus papain-like protease up-regulates the collagen expression through non-Samd TGF-β1 signaling Proteasome Inhibition In Vivo Promotes Survival in a Lethal Murine Model of Severe Acute Respiratory Syndrome Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages The SARS-CoV nucleocapsid protein: A protein with multifarious activities Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Novel Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants Animal models for SARS and MERS coronaviruses The SARS-Coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes Inhibitory effects of recombinant human cystatin C on human coronaviruses Effect of Flavonoids on Upper Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis Effective inhibition of MERS-CoV infection by resveratrol Effect of CYSTUS052 and green tea on subjective symptoms in patients with infection of the upper respiratory tract Cistus incanus (CYSTUS052) for treating patients with infection of the upper respiratory tract. Ub [6] and a study showing that inhibition of PLP protease activity results in reduced NF-kB (but not IRF3) antagonism keywords: activity; coronavirus; cov; dub; inhibitors; irf3; mers; papain; plp; plps; protease; response; sars cache: cord-325261-bdumhy5b.txt plain text: cord-325261-bdumhy5b.txt item: #375 of 515 id: cord-325574-4zf9qtlh author: Farag, Elmoubasher title: Drivers of MERS-CoV Emergence in Qatar date: 2018-12-31 words: 4347 flesch: 58 summary: According to experts, although camel racing has traditionally been part of the Bedouin culture, the organized racing business went through major changes over the past decades. The camel farms that are located near the Al-Shehaniya camel racing area are mostly used for racing camels. keywords: animal; camel; changes; cov; figure; human; mers; population; qatar; racing cache: cord-325574-4zf9qtlh.txt plain text: cord-325574-4zf9qtlh.txt item: #376 of 515 id: cord-325902-33pxylb3 author: Hemida, Maged Gomaa title: Middle East Respiratory Syndrome Coronavirus and the One Health concept date: 2019-08-22 words: 6357 flesch: 52 summary: The prevalence rate of MERS-CoV in primary cases among males is relatively higher than that of females (Darling et al., 2017) , which may be because exposure to infected dromedary camels is much higher in males than in females. In this article, I highlight the known information about the MERS-CoV infection and its pathogenesis in humans, the patterns of MERS-CoV in dromedary camels, the potential roles of other animals in the transmission cycle of MERS-CoV, and the interaction of MERS-CoV/humans/animals. keywords: camels; coronavirus; cov; east; et al; human; infection; mers; middle; transmission; virus cache: cord-325902-33pxylb3.txt plain text: cord-325902-33pxylb3.txt item: #377 of 515 id: cord-326133-d46wbfrx author: Nakayasu, Ernesto S. title: MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses date: 2016-05-10 words: 6114 flesch: 31 summary: Although these small differences in protein extraction results seen using MPLEx should be considered in proteomics studies employing absolute quantification, they likely do not introduce artifacts in the results, as these studies typically have very small (up to 15%) errors when stable isotope-labeled peptides are used as internal standards (28) and up to 2-fold to 3-fold variations in label-free analyses (29, 30) . We then calculated the variance of protein measurements by comparing different extraction protocols. keywords: analysis; data; extraction; fig; measurements; metabolites; mplex; protein; proteomics; protocol; results; samples cache: cord-326133-d46wbfrx.txt plain text: cord-326133-d46wbfrx.txt item: #378 of 515 id: cord-326718-jboiufoq author: Deming, Meagan E. title: COVID-19 and Lessons to Be Learned from Prior Coronavirus Outbreaks date: 2020-07-17 words: 2549 flesch: 33 summary: Both strategies result in a lower R 0 and significant decline in COVID-19 cases. 326718 cord_uid: jboiufoq nan A novel coronavirus (CoV) was quickly recognized as the cause of a cluster of severe pneumonia cases in China around December 2019. keywords: angiotensin; coronavirus; cov; cov-2; covid-19; enzyme; sars cache: cord-326718-jboiufoq.txt plain text: cord-326718-jboiufoq.txt item: #379 of 515 id: cord-326768-uo6482ah author: Hashem, Anwar M. title: MERS‐CoV, influenza and other respiratory viruses among symptomatic pilgrims during 2014 Hajj season date: 2019-02-20 words: 1841 flesch: 35 summary: Hajj: infectious disease surveillance and control Hajj-associated viral respiratory infections: a systematic review Health risks at the Hajj Respiratory tract infection during Hajj Causes of hospitalization of pilgrims in the Hajj season of the Islamic year Infections in travellers returning to Turkey from the Arabian peninsula: a retrospective cross-sectional multicenter study Respiratory tract infections during the annual Hajj: potential risks and mitigation strategies The prevalence of acute respiratory symptoms and role of protective measures among Malaysian hajj pilgrims Influenza a common viral infection among Hajj pilgrims: time for routine surveillance and vaccination High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Circulation of respiratory viruses among pilgrims during the 2012 Hajj pilgrimage Respiratory viruses and bacteria among pilgrims during the Influenza and respiratory syncytial virus infections in British Hajj pilgrims 2 Patterns of reported respiratory symptoms and detected respiratory viruses during Hajj days. The remaining nine coinfections were due to the unique combination of respiratory viruses (Table 3) . keywords: hajj; influenza; pilgrims; respiratory; viruses cache: cord-326768-uo6482ah.txt plain text: cord-326768-uo6482ah.txt item: #380 of 515 id: cord-326851-0jxdnm1l author: Lee, Sang M. title: Lessons Learned from Battling COVID-19: The Korean Experience date: 2020-10-16 words: 9670 flesch: 46 summary: This study attempts to present directions for potential changes in the crisis response systems of public healthcare worldwide, by analyzing COVID-19 pandemic response cases, both successes and failures, in Korea. On 10 March 2020, the Korean government established residential treatment centers to treat confirmed COVID-19 patients while maintaining their quarantine. keywords: cases; covid-19; covid-19 pandemic; crisis; daegu; government; healthcare; hospital; infection; korea; pandemic; patients; people; public; response; spread; system; virus cache: cord-326851-0jxdnm1l.txt plain text: cord-326851-0jxdnm1l.txt item: #381 of 515 id: cord-326864-i1r3bv4p author: Hon, Kam Lun title: Coronavirus disease 2019 (COVID-19): latest developments in potential treatments date: 2020-06-29 words: 6276 flesch: 37 summary: A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical features of patients infected with 2019 novel coronavirus in Wuhan Pathological findings of COVID-19 associated with acute respiratory distress syndrome The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of middle east respiratory syndrome coronavirus infection in the United Arab Emirates Severe acute respiratory syndrome vs. The Middle East respiratory syndrome Severe acute respiratory syndrome: SARS or not SARS Typical or atypical pneumonia and severe acute respiratory symptoms in PICU Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission Q&A: similarities and differences -COVID-19 and influenza Report of the WHO-China Joint Mission on Coronavirus Disease Solidarity clinical trial for COVID-19 treatments A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) Intensive care management of coronavirus disease 2019 (COVID-19 ): challenges and recommendations Compassionate use of remdesivir for patients with severe covid-19 COVID-19 treatment: a review of early and emerging options Remdesivir as a possible therapeutic option for the COVID-19 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial NIH clinical trial shows remdesivir accelerates recovery from advanced COVID-19 Gilead announces results from phase 3 trial of investigational antiviral remdesivir in patients with severe COVID-19 Study to evaluate the safety and antiviral activity of remdesivir (GS-5734 TM ) in participants with moderate coronavirus disease (COVID-19) compared to standard of care treatment Study to evaluate the safety and antiviral activity of remdesivir (GS-5734 TM ) in participants with severe coronavirus disease (COVID-19 Adaptive COVID-19 treatment trial Multi-centre, adaptive, randomized trial of the safety and efficacy of treatments of COVID-19 in hospitalized adults A trial of lopinavir-ritonavir in adults hospitalized with severe covid-19 Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro Lopinavir/ritonavir, ribavirin and IFN-beta combination for nCoV treatment Multicenter clinical study on the efficacy and safety of Xiyanping injection in the treatment of new coronavirus infection pneumonia (General and Severe An investigation into beneficial effects of interferon beta 1a, compared to interferon beta 1b and the base therapeutic regiment in moderate to severe COVID-19: a randomized clinical trial (DIC) Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Novel coronavirus treatment with ribavirin: groundwork for an evaluation concerning COVID-19 SARS: systematic review of treatment effects Clinical features and short-term outcomes of 144 patients with SARS in the Greater Toronto area Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin National Health Commission & State Administration of Traditional Chinese Medicine. [34] [35] Therapeutics for COVID-19 The majority of COVID-19 patients, especially children, are either asymptomatic or have mild symptoms, and will likely recover by managing their own symptoms without the need for hospitalisation. keywords: clinical; coronavirus; cov-2; covid-19; disease; lopinavir; mers; patients; ritonavir; sars; syndrome; treatment; trial; use cache: cord-326864-i1r3bv4p.txt plain text: cord-326864-i1r3bv4p.txt item: #382 of 515 id: cord-327063-ea7a1xfl author: Dhama, Kuldeep title: SARS-CoV-2 jumping the species barrier: zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus date: 2020-08-02 words: 11075 flesch: 42 summary: CORONAVIRUS DISEASE 2019 UPDATE (22): COMPANION ANIMAL, DOG SUSPECTED, REQUEST FOR INFORMATION Infection of dogs with SARS-CoV-2 Coronavirus can infect cats -dogs, not so much First detection and genome sequencing of SARS-CoV-2 in an infected cat in France Virology: SARS virus infection of cats and ferrets Belgian cat infected by owner. key: cord-327063-ea7a1xfl authors: Dhama, Kuldeep; Patel, Shailesh Kumar; Sharun, Khan; Pathak, Mamta; Tiwari, Ruchi; Yatoo, Mohd Iqbal; Malik, Yashpal Singh; Sah, Ranjit; Rabaan, Ali A.; Panwar, Parmod Kumar; Singh, Karam Pal; Michalak, Izabela; Chaicumpa, Wanpen; Martinez-Pulgarin, Dayron F.; Bonilla-Aldana, D. Katterine; Rodriguez-Morales, Alfonso J. title: SARS-CoV-2 jumping the species barrier: zoonotic lessons from SARS, MERS and recent advances to combat this pandemic virus date: 2020-08-02 journal: keywords: animal; bats; cases; coronavirus; cov-2; covid-19; covs; disease; health; host; human; infection; mers; novel; pandemic; patients; pneumonia; receptor; sars; species; spillover; transmission cache: cord-327063-ea7a1xfl.txt plain text: cord-327063-ea7a1xfl.txt item: #383 of 515 id: cord-327685-fymfqvp3 author: Channappanavar, Rudragouda title: Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology date: 2017-05-02 words: 5844 flesch: 29 summary: expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection Exacerbated innate host response to SARS-CoV in aged non-human primates Toll-like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Infection with MERS-CoV causes lethal pneumonia in the common marmoset Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/ 2012 isolates does not result in lethal disease Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection Rapid generation of a mouse model for Middle East respiratory syndrome Animal models for SARS and MERS coronaviruses Animal models of Middle East respiratory syndrome coronavirus infection Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection A mouse model for MERS coronavirusinduced acute respiratory distress syndrome Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane Interaction of SARS and MERS coronaviruses with the antiviral interferon response Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling Interferon and cytokine responses to SARS-coronavirus infection SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists SARS-CoV nucleocapsid protein antagonizes IFN-beta response by targeting initial step of IFN-beta induction pathway, and its C-terminal region is critical for the antagonism Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3 The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Initial viral load and the outcomes of SARS Proliferative growth of SARS coronavirus in Vero E6 cells Viral load kinetics of MERS coronavirus infection Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice Adaptive immune cells temper initial innate responses Not so fast: adaptive suppression of innate immunity Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection Genome wide identification of SARS-CoV susceptibility loci using the collaborative cross Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome SARS: systematic review of treatment effects Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Treatment with interferon-alpha2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Coronaviruses-drug discovery and therapeutic options IFNlambda is a potent anti-influenza therapeutic without the inflammatory side effects of IFNalpha treatment IFN-lambda resolves inflammation via suppression of neutrophil infiltration and IL-1beta production Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury The TLR4 antagonist Eritoran protects mice from lethal influenza infection Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus Silencing of CCR2 in myocarditis Therapeutic siRNA silencing in inflammatory monocytes in mice Immunomodulatory therapy for severe influenza The effect of inhibition of PP1 and TNFalpha signaling on pathogenesis of SARS coronavirus Acknowledgements We thank Dr. Anthony Fehr for careful review of this manuscript. key: cord-327685-fymfqvp3 authors: Channappanavar, Rudragouda; Perlman, Stanley title: Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology date: 2017-05-02 journal: keywords: acute; coronavirus; cov; disease; ifn; infection; mers; mice; pathogenic; responses; sars; syndrome cache: cord-327685-fymfqvp3.txt plain text: cord-327685-fymfqvp3.txt item: #384 of 515 id: cord-327863-6cw9f7qu author: Majumder, Maimuna S. title: Mortality Risk Factors for Middle East Respiratory Syndrome Outbreak, South Korea, 2015 date: 2015-11-17 words: 1380 flesch: 47 summary: For 159 case-patients with known outcomes and complete case histories, we found that older age and preexisting concurrent health conditions were risk factors for death. Per WHO definitions, 25 (16%) had concurrent health conditions and 22 (14%) were health care workers. keywords: case; health; mers; patients cache: cord-327863-6cw9f7qu.txt plain text: cord-327863-6cw9f7qu.txt item: #385 of 515 id: cord-327867-1wkbjtji author: Da'ar, Omar B. title: Underlying trend, seasonality, prediction, forecasting and the contribution of risk factors: an analysis of globally reported cases of Middle East Respiratory Syndrome Coronavirus date: 2018-06-11 words: 3188 flesch: 45 summary: MERS situation update Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study Building predictive models for MERS-CoV infections using data mining techniques Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Risk factors for severity and mortality in patients with MERS-CoV: analysis of publicly available data from Saudi Arabia Risks of death and severe disease in patients with Middle East respiratory syndrome coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Hospital outbreak of Middle East respiratory syndrome coronavirus Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Evidence of person-to-person transmission within a family cluster of novel coronavirus infections The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections MERS-CoV outbreak in Jeddah-a link to health care facilities Human-Dromedary camel interactions and the risk of acquiring zoonotic Middle East respiratory syndrome coronavirus infection Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Acknowledgements. The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Development of a risk-prediction model for Middle East respiratory syndrome coronavirus infection in dialysis patients Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Severe acute respiratory syndrome vs. the Middle East respiratory syndrome Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus (MERS-CoV). keywords: cases; cov; mers; middle; series; trend cache: cord-327867-1wkbjtji.txt plain text: cord-327867-1wkbjtji.txt item: #386 of 515 id: cord-328000-i9tzr13z author: Cockrell, Adam S. title: Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice date: 2018-07-24 words: 11029 flesch: 29 summary: In addition to assessing etiologies of known hCoVs, mouse models have clinically predictive value as tools to appraise potential disease phenotypes associated with pre-emergent CoVs. Taking into account a number of practical considerations when comparing models for both SARS-CoV and MERS-CoV, mouse models appear to be the most pragmatic (Table 1) . keywords: clinical; coronavirus; cov; disease; et al; hdpp4; host; human; infection; mers; mice; models; mouse; pathogenesis; receptor; sars; spike; studies; syndrome; therapeutic cache: cord-328000-i9tzr13z.txt plain text: cord-328000-i9tzr13z.txt item: #387 of 515 id: cord-328175-4i3cz20j author: van Doremalen, Neeltje title: Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets date: 2017-07-31 words: 5151 flesch: 44 summary: Convalescent plasma has been identified by the World Health Organization (WHO) and the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) as a potential treatment against MERS-CoV to reduce clinical consequences of MERS-CoV infection (2013 , WHO, 2014 and recently a study protocol was developed to investigate the feasibility of convalescent plasma treatment in MERS patients (Arabi et al., 2015) . Convalescent plasma treatment of patients with severe A(H1N1)pdm09 influenza virus infection resulted in reduced mortality and respiratory tract viral load (Hung et al., 2011) . keywords: animals; control; convalescent; cov; hyperimmune; infection; mers; plasma; respiratory; treatment cache: cord-328175-4i3cz20j.txt plain text: cord-328175-4i3cz20j.txt item: #388 of 515 id: cord-328298-tm7gds8h author: Gardner, Lauren M. title: Risk of global spread of Middle East respiratory syndrome coronavirus (MERS-CoV) via the air transport network date: 2016-09-05 words: 4998 flesch: 48 summary: For both scenarios all countries that have previously reported travel acquired cases were identified in the top 50, with the majority of countries reporting travel imported cases identified in the top 20. It should be noted, however, that several high-risk countries identified by the model have not had an imported case as of yet, whilst lower risk countries have. keywords: cases; countries; cov; east; mers; middle; risk; travel cache: cord-328298-tm7gds8h.txt plain text: cord-328298-tm7gds8h.txt item: #389 of 515 id: cord-328361-hyrke6j2 author: Ithete, Ndapewa Laudika title: Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa date: 2013-10-17 words: 1196 flesch: 41 summary: Significantly more bacteremia E. coli isolates than urine E. coli isolates were resistant to ciprofloxacin (25.7% Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Circulation of group 2 coronaviruses in a bat species common to urban areas in Western Europe Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Coronaviruses in South African bats Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features Detection of alpha and betacoronaviruses in multiple Iberian bat species Group C betacoronavirus in bat guano fertilizer Coronaviruses in bats from Mexico Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry We thank Tobias Bleicker, Sebastian Brünink, and Monika Eschbach-Bludau for technical assistance; Thomas Seifert, Sonja Matthee, and Conrad Mathee for invaluable help; and Anna-Marie Corman for assistance with geographic information processing. The smaller 152to 396-nt RdRp fragments of 2c bat CoVs from a Hypsugo savii bat in Spain (7), bat guano in Thailand (8), and a Nyctinomops bat in Mexico (9) showed no or only partial overlap with the 816-nt fragment generated in this study; thus, a direct comparison could not be done. keywords: bat; bats; cov; mers; sequence cache: cord-328361-hyrke6j2.txt plain text: cord-328361-hyrke6j2.txt item: #390 of 515 id: cord-328366-new4d9jg author: Bleibtreu, A. title: Delayed management of Staphyloccocus aureus infective endocarditis in a Middle East respiratory syndrome coronavirus possible case hospitalized in 2015 in Paris, France date: 2017-06-30 words: 831 flesch: 51 summary: Clinical Microbiology and Infection DOI: 10.1016/j.cmi.2016.11.021 sha: doc_id: 328366 cord_uid: new4d9jg nan The risk of emerging infectious diseases such as Middle East respiratory syndrome coronavirus (MERS-CoV) It is of particular importance given the ratio between the number of cases of emerging infectious diseases and the number of 'classical' infections. keywords: cov; infection; mers cache: cord-328366-new4d9jg.txt plain text: cord-328366-new4d9jg.txt item: #391 of 515 id: cord-328835-r9znjkfo author: Favre, Guillaume title: 2019-nCoV epidemic: what about pregnancies? date: 2020-02-06 words: 339 flesch: 46 summary: Considering that the 2019-nCoV seems to have a similar pathogenic potential as SARS-CoV and MERS-CoV, 4 pregnant women are at increased risk of severe infections, there are no specific clinical signs of coronavirus infections preceding severe complications, 5 coronaviruses have the potential to cause severe maternal or perinatal adverse outcomes, or both, 2,3 and the current lack of data on the consequences of a 2019-nCoV infection during pregnancy, we recommend systematic screening of any suspected 2019-nCoV infection during pregnancy. key: cord-328835-r9znjkfo authors: Favre, Guillaume; Pomar, Léo; Musso, Didier; Baud, David title: 2019-nCoV epidemic: what about pregnancies? date: 2020-02-06 journal: Lancet DOI: 10.1016/s0140-6736(20)30311-1 sha: doc_id: 328835 cord_uid: r9znjkfo nan Members of the coronavirus family responsible for severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV) are known to be responsible for severe complications during pregnancy. keywords: women cache: cord-328835-r9znjkfo.txt plain text: cord-328835-r9znjkfo.txt item: #392 of 515 id: cord-329010-n0mz098o author: McKee, Dwight L. title: Candidate drugs against SARS-CoV-2 and COVID-19 date: 2020-04-29 words: 5211 flesch: 32 summary: V. Effects on the pancreatic enzymes and experimental acute pancreatitis in rats Plasma collection using nafamostat mesilate and dipyridamole as an anticoagulant Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate for predicted severe acute pancreatitis: a multicenter, randomized, open-label, phase 2 trial Identification of nafamostat as a potent inhibitor of middle east respiratory syndrome coronavirus S protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronoavirus Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors, Can Hydroxychloroquine: from malaria to autoimmunity New insights into the antiviral effects of chloroquine Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) At day 21, SARS patients treated with lopinavir/ritonavir had a milder disease course in terms of diarrhea, recurrence of fever, worsening of chest radiographs and reduction of viral load, compared to a historical control group [95] . keywords: ace2; antiviral; cell; chloroquine; coronavirus; cov-2; covid-19; infection; lopinavir; protein; ritonavir; sars; treatment cache: cord-329010-n0mz098o.txt plain text: cord-329010-n0mz098o.txt item: #393 of 515 id: cord-329190-kv9n2qj3 author: Rabaan, Ali A. title: A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective date: 2017-09-01 words: 8912 flesch: 43 summary: www.inovio.com/products/ infectious-disease-vaccines/mers A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates MERS-CoV vaccine candidates in development: the current landscape Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Toll-Like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Bioinformatics analysis on molecular mechanism of Ribavirin and interferon-a in treating MERS-CoV Treatment with lopinavir/ritonavir or interferon-b1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Middle Eastern Respiratory syndrome Corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome coronavirus S protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design Small molecules targeting severe acute respiratory syndrome human coronavirus Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Towards improving clinical management of Middle East respiratory syndrome coronavirus infection Ninth Report of the International Committee on Taxonomy of Viruses Cross host transmission in the emergence of MERS coronavirus Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Close relative of human Middle East respiratory syndrome coronavirus in bat MERS-Coronavirus molecular epidemiology and genetic analysis -Origin and evolution MERS coronavirus: diagnostics, epidemiology and transmission Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics Evolutionary dynamics of MERS-CoV: potential recombination, positive selection and transmission MERS-CoV spike protein: a key target for antivirals Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission Protease inhibitors targeting coronavirus and filovirus entry Critical assessment of the important residues involved in the dimerization and catalysis of MERS Coronavirus Main protease Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways Adjunctive therapies and immunomodulating agents for severe influenza Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis SARS: systematic review of treatment effects Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol Treatment strategies for Middle East respiratory syndrome coronavirus Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Evaluation of candidate vaccine approaches for MERS-CoV A conformationdependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Passive transfer of A Germline-like neutralizing human monoclonal antibody protects transgenic mice against Lethal Middle East respiratory syndrome coronavirus infection Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-Specific human monoclonal antibody protects rabbits from MERS-CoV infection Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeatderived peptides Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection A truncated receptorbinding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: implication for designing novel mucosal MERS vaccines Receptor-binding domain-based subunit vaccines against MERS-CoV Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus Recombinant receptor-binding domains of multiple Middle East respiratory syndrome coronaviruses (MERS-CoVs) induce cross-neutralizing antibodies against divergent human and camel MERS-CoVs and antibody escape mutants Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice Toward developing a preventive MERS-CoV Vaccine-Report from a workshop organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute Protective efficacy of recombinant modified vaccinia virus Ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus A highly immunogenic and protective Middle East respiratory syndrome coronavirus vaccine based on a recombinant measles virus vaccine platform An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels GLS-5300 SynCon® immunotherapy targeting Middle East Respiratory Syndrome. keywords: antibody; coronavirus; cov; east; human; ifn; infection; mers; middle; potential; protein; respiratory; sars; syndrome; therapies; treatment; vitro cache: cord-329190-kv9n2qj3.txt plain text: cord-329190-kv9n2qj3.txt item: #394 of 515 id: cord-329876-4cgrjnjo author: Lei, Jian title: Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin date: 2016-05-30 words: 6867 flesch: 59 summary: The papainlike protease (PL pro ) of MERS-CoV (or SARS-CoV) is involved in both of these tasks (Yang et al., 2013; Barretto et al, 2005) . The structure of PL pro can be divided into two parts: a ubiquitin-like (Ubl) domain and a catalytic domain with thumb, palm, and fingers subdomains. keywords: chain; complex; cov; cov pl; et al; mers; pl pro; pro; sars; ubiquitin cache: cord-329876-4cgrjnjo.txt plain text: cord-329876-4cgrjnjo.txt item: #395 of 515 id: cord-329959-4yecwdlo author: Lin, Min-Han title: Disulfiram can inhibit MERS and SARS coronavirus papain-like proteases via different modes date: 2017-12-28 words: 5597 flesch: 46 summary: Next, we evaluated PL pro inhibition in the presence of disulfiram combined with 6TG and/or MPA by proteolytic assays using a peptidyl substrate. The observed inactivation rate constants (k inact ) from panel B were replotted against disulfiram concentration. keywords: cov; cov pl; disulfiram; et al; inhibition; mers; pl pro; pro; sars cache: cord-329959-4yecwdlo.txt plain text: cord-329959-4yecwdlo.txt item: #396 of 515 id: cord-330315-upcf15q5 author: Oudshoorn, Diede title: Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication date: 2017-11-21 words: 7740 flesch: 41 summary: The angular coverage for each single-axis tilt series was 130°sampled in Identification of a novel coronavirus in patients with severe acute respiratory syndrome A novel coronavirus associated with severe acute respiratory syndrome Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Coronaviruses post-SARS: update on replication and pathogenesis SARS and MERS: recent insights into emerging coronaviruses Nidovirales: evolving the largest RNA virus genome The nonstructural proteins directing coronavirus RNA synthesis and processing Virus-encoded proteinases and proteolytic processing in the Nidovirales The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design Nidovirus papain-like proteases: multifunctional enzymes with protease, deubiquitinating and deISGylating activities Recent advances in targeting viral proteases for the discovery of novel antivirals Modification of intracellular membrane structures for virus replication Cytoplasmic viral replication complexes Endoplasmic reticulum: the favorite intracellular niche for viral replication and assembly Untangling membrane rearrangement in the nidovirales Biogenesis and architecture of arterivirus replication organelles SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum RNA replication of mouse hepatitis virus takes place at double-membrane vesicles MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-alpha treatment Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Ultrastructural characterization of SARS coronavirus Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus Morphogenesis of coronavirus HCoV-NL63 in cell culture: a transmission electron microscopic study Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the Middle East respiratory syndrome virus Ultrastructural characterization of membranous torovirus replication factories Infectious bronchitis virus generates spherules from zippered endoplasmic reticulum membranes Doublestranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses Complex dynamic development of poliovirus membranous replication complexes The transformation of enterovirus replication structures: a three-dimensional study of single-and doublemembrane compartments Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication Bioinformatics and functional analyses of coronavirus nonstructural proteins involved in the formation of replicative organelles Localization and membrane topology of coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication Topology and membrane anchoring of the coronavirus replication complex: not all hydrophobic domains of nsp3 and nsp6 are membrane spanning Detection of nonstructural protein 6 in murine coronavirus-infected cells and analysis of the transmembrane topology by using bioinformatics and molecular approaches Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications Genetic analysis of murine hepatitis virus nsp4 in virus replication Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function Non-structural proteins 2 and 3 interact to modify host cell membranes during the formation of the arterivirus replication complex Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles Expression vector system based on the chicken beta-actin promoter directs efficient production of interleukin-5 Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease Mobility and interactions of coronavirus nonstructural protein 4 Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4 Cubic membranes: a legend beyond the Flatland* of cell membrane organization Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles A positive-strand RNA virus replication complex parallels form and function of retrovirus capsids 2012. When MERS-CoV nsp3 and nsp4 were expressed in the same cell, either by cotransfection or by expression of the self-cleaving nsp3-4 polyprotein, a remarkably different set of membrane structures was observed ( Fig. 2E and F) . keywords: cells; coronavirus; cov; dmv; dmvs; expression; fig; formation; membrane; mers; nsp3; nsp4; polyprotein; sars; structures cache: cord-330315-upcf15q5.txt plain text: cord-330315-upcf15q5.txt item: #397 of 515 id: cord-330343-p7a8chn4 author: Kelly-Cirino, Cassandra title: An updated roadmap for MERS-CoV research and product development: focus on diagnostics date: 2019-02-01 words: 5814 flesch: 26 summary: WHO MERS-COV R&D Blueprint Plan of Action R&D Blueprint for action to prevent epidemics Progress on the global response, remaining challenges and the way forward Evidence for camel-tohuman transmission of MERS coronavirus Human-dromedary camel interactions and the risk of acquiring zoonotic middle east respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt MERS coronaviruses in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Absence of Middle East Respiratory Syndrome Coronavirus in Camelids Antibodies against MERS coronavirus in dromedary camels Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Lack of middle East respiratory syndrome coronavirus transmission from infected camels MERS coronavirus in dromedary camel herd, Saudi Arabia Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Serologic Evidence for MERS-CoV Infection in Dromedary Camels Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation MERS-CoV situation update, Map 1. MERS-CoV livestock field surveys by country Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates MERS CoV: OIE -World organisation for animal health Occupational exposure to dromedaries and risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study Middle East Respiratory Syndrome (MERS) | Symptoms & Complications | CDC Middle East respiratory syndrome coronavirus disease in children Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia Transmission of MERScoronavirus in household contacts Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description The Role of Super-Spreaders in Infectious Disease Super-spreading events of MERS-CoV infection MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus WHO | Infection prevention and control (IPC) guidance summary. WHO MERS-COV Lab Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Performance and clinical validation of the RealStar MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Development of dual taqman based one-step rrt-pcr assay panel for rapid and accurate diagnostic test of MERS-CoV: a novel human coronavirus, ahead of hajj pilgrimage Development and validation of a rapid immunochromatographic assay for detection of Middle East respiratory syndrome coronavirus antigen in dromedary camels An isothermal, label-free, and rapid one-step RNA amplification/detection assay for diagnosis of respiratory viral infections Comparison of ePlex respiratory pathogen panel with laboratory-developed real-time pcr assays for detection of respiratory pathogens Clinical validation of 3 commercial real-time reverse transcriptase polymerase chain reaction assays for the detection of Middle East respiratory syndrome coronavirus from upper respiratory tract specimens A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus A highly specific rapid antigen detection assay for on-site diagnosis of MERS Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Lateral flow assays Development of monoclonal antibody and diagnostic test for middle east respiratory syndrome coronavirus using cell-free synthesized nucleocapsid antigen Middle East respiratory syndrome (MERS) coronavirus and dromedaries Identification of Mycoplasma suis antigens and development of a multiplex microbead immunoassay Serosurveillance of viral pathogens circulating in West Africa Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses A multiplex liquid-chip assay based on Luminex xMAP technology for simultaneous detection of six common respiratory viruses Surveillance and testing for middle east respiratory syndrome coronavirus Using Healthmap to analyse Middle East Respiratory Syndrome (MERS) data Progress in promoting data sharing in public health emergencies WHO | Influenza surveillance outputs Data sharing: make outbreak research open access The weapon potential of a microbe Biological agents: weapons of warfare and bioterrorism Explanation of the Nagoya Protocol on Access and Benefit Sharing and its implication for microbiology Global scientific research commons under the Nagoya Protocol: keywords: camels; coronavirus; cov; detection; development; east; infection; laboratory; mers; middle; middle east; respiratory; syndrome; tests cache: cord-330343-p7a8chn4.txt plain text: cord-330343-p7a8chn4.txt item: #398 of 515 id: cord-330583-ltkpt80u author: Lee, Kyu-Myoung title: Factors Influencing the Response to Infectious Diseases: Focusing on the Case of SARS and MERS in South Korea date: 2019-04-22 words: 9205 flesch: 31 summary: As the results conducted meta-analyses to comprehensively analyze the correlations of factors influencing disaster response from a Korean context, the findings show that the legislative factor had direct and indirect influence on the overall process of infectious disease response and that Leadership of the central government, establishment of an intergovernmental response system, the need for communication, information sharing and disclosure and onsite response were identified as key factors influencing effective infectious disease response. Education and training was analyzed as a factor influencing infectious disease response, while the interview results revealed that education and training not only had a direct influence on response but also had an impact on the relationship between the people in charge of disaster response. keywords: analysis; disaster response; disease; factors; information; korea; management; mers; meta; sars; studies; study; system cache: cord-330583-ltkpt80u.txt plain text: cord-330583-ltkpt80u.txt item: #399 of 515 id: cord-330913-8aezw81h author: Albahri, A. S. title: Role of biological Data Mining and Machine Learning Techniques in Detecting and Diagnosing the Novel Coronavirus (COVID-19): A Systematic Review date: 2020-05-25 words: 4769 flesch: 46 summary: Two attributes, namely, (1) personal patient information attributes and (2) CoV attributes, were recognised in the collected studies to explore the effects of CoV features and classes on case study datasets used with ML algorithms. Despite the increasing rates of death and the number of people affected with CoV, developments based on ML algorithms to improve CoV datasets remain at a redefinition stage, especially for COVID-19. keywords: algorithms; cov; data; mers; mining; studies; study; virus cache: cord-330913-8aezw81h.txt plain text: cord-330913-8aezw81h.txt item: #400 of 515 id: cord-331022-tek4u751 author: Sinderewicz, Emilia title: Immune Response to COVID-19: Can We Benefit from the SARS-CoV and MERS-CoV Pandemic Experience? date: 2020-09-09 words: 8489 flesch: 40 summary: A comparison of the content of proinflammatory Th1 and Th2 cytokines in the serum of SARS patients with healthy controls documented a significantly greater concentration of TNF-α, IL-6, IL-8, IL-10, and IL-12 in the early stage of the SARS-CoV infection [32, 40] . It has been documented that increased IL-6 concentration in plasma of SARS patients was significantly increased in severe cases, but not in convalescent or control subjects, suggesting a positive correlation between serum IL-6 level and disease severity [61] . keywords: cells; coronavirus; cov; cov-2; covid-19; immune; infection; mers; patients; protein; response; sars; syndrome cache: cord-331022-tek4u751.txt plain text: cord-331022-tek4u751.txt item: #401 of 515 id: cord-331228-wbd0s4fo author: Shehata, Mahmoud M. title: Middle East respiratory syndrome coronavirus: a comprehensive review date: 2016-01-20 words: 7527 flesch: 43 summary: respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Cyclophilins as modulators of viral replication Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis Testing of Middle East respiratory syndrome coronavirus replication inhibitors for the ability to block viral entry Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The newly emerged SARS-like coronavirus HCoV-EMC also has an Achilles' heel: current effective inhibitor targeting a 3C-like protease Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Mahmoud M. Shehata, Mokhtar R. Gomaa, Mohamed A. Ali, and Ghazi Kayali declare that they have no conflict of interest. respiratory syndrome coronavirus The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Furin at the cutting edge: from protein traffic to embryogenesis and disease MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells SARS-beginning to understand a new virus Wildtype and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Pneumonia from human coronavirus in a macaque model Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Infection with MERS-CoV causes lethal pneumonia in the common marmoset The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Novel coronavirus-Saudi Arabia: human isolate. keywords: antibodies; arabia; camels; cases; cell; coronavirus; cov; east; human; infection; mers; middle; middle east; protein; saudi; syndrome; syndrome coronavirus cache: cord-331228-wbd0s4fo.txt plain text: cord-331228-wbd0s4fo.txt item: #402 of 515 id: cord-331558-6rqd3fmj author: Sun, Chuan-bin title: Role of the Eye in Transmitting Human Coronavirus: What We Know and What We Do Not Know date: 2020-04-24 words: 5514 flesch: 40 summary: However, the number of 2019-nCoV infected patients in the first two months was nearly 10 times that of SARS patients in total, which indicated that 2019-nCoV is more transmissible than SARS-CoV and MERS-CoV (16) . Patients infected by 2019-nCoV, similar to SARS cases, mostly present with non-specific symptoms such as fever, dry cough, and dyspnoea, or, in some cases, no evident symptoms, at the early phase of the disease (9, 16, (23) (24) (25) (26) (27) 48) . keywords: conjunctival; coronavirus; cov; covid-19; covs; human; infection; mers; ncov; patients; sars cache: cord-331558-6rqd3fmj.txt plain text: cord-331558-6rqd3fmj.txt item: #403 of 515 id: cord-331980-m6dflwmm author: Alqahtani, Amani S. title: Association between Australian Hajj Pilgrims’ awareness of MERS-CoV, and their compliance with preventive measures and exposure to camels date: 2016-07-18 words: 2322 flesch: 50 summary: This may indicate that among Hajj pilgrims, there may be unique factors and barriers that affect their compliance with preventive measures against the infectious diseases which needs further investigation. Only 28% of Australian Hajj pilgrims were aware of MERS-CoV in Saudi Arabia. keywords: camels; cov; hajj; mers; pilgrims cache: cord-331980-m6dflwmm.txt plain text: cord-331980-m6dflwmm.txt item: #404 of 515 id: cord-332237-8oykgp0h author: Omrani, Ali S title: Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study date: 2014-09-29 words: 3323 flesch: 44 summary: Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-11th update Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Hospital outbreak of Middle East respiratory syndrome coronavirus Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical management of severe acute respiratory infections when novel coronavirus is suspected: what to do and what not to do International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) key: cord-332237-8oykgp0h authors: Omrani, Ali S; Saad, Mustafa M; Baig, Kamran; Bahloul, Abdelkarim; Abdul-Matin, Mohammed; Alaidaroos, Amal Y; Almakhlafi, Ghaleb A; Albarrak, Mohammed M; Memish, Ziad A; Albarrak, Ali M title: Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study date: 2014-09-29 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(14)70920-x sha: doc_id: 332237 cord_uid: 8oykgp0h BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) infection is associated with high mortality and has no approved antiviral therapy. keywords: cov; infection; interferon; mers; patients; ribavirin; treatment cache: cord-332237-8oykgp0h.txt plain text: cord-332237-8oykgp0h.txt item: #405 of 515 id: cord-332268-x30svp5y author: Bearden, Donna M. title: COVID-19: a primer for healthcare providers date: 2020-05-20 words: 3706 flesch: 47 summary: In fact, the use of methylprednisolone as an intervention for SARS patients was associated with a higher 30-day mortality rate [1] . A randomized, placebo-controlled study of SARS patients suggested that those given steroids early in the infection developed prolonged viremia. keywords: china; coronavirus; covid-19; disease; mers; novel; patients; sars; spread cache: cord-332268-x30svp5y.txt plain text: cord-332268-x30svp5y.txt item: #406 of 515 id: cord-332952-d5l60cgc author: None title: MERS: Progress on the global response, remaining challenges and the way forward date: 2018-09-17 words: 5562 flesch: 13 summary: The prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) antibodies in dromedary camels in Israel Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia MERS outbreak in Korea: hospital-to-hospital transmission Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS outbreak units Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Influenza not MERS CoV among returning Hajj and Umrah pilgrims with respiratory illness Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus No MERS-CoV but positive influenza viruses in returning Hajj pilgrims, China MERS coronavirus in dromedary camel herd, Saudi Arabia Lack of Middle East respiratory syndrome coronavirus transmission from infected camels Acute respiratory infections in travelers returning from MERS-CoV-affected areas Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program Prevalence of MERS-CoV Nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications Antibodies against MERS coronavirus in dromedary camels Absence of Middle East respiratory syndrome coronavirus in Camelids Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir Infectivity of an asymptomatic patient with Middle East respiratory syndrome coronavirus infection Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study MERS coronavirus neutralizing antibodies in camels Event based surveillance of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Bangladesh among pilgrims and travelers from the Middle East: an update for the period High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels MERS-CoV outbreak in Jeddah -a link to health care facilities Group on MERS-cov Infection in Animals Infection with Coronavirus in Camels Middle East Respiratory Syndrome Coronavirus (MERS-cov) Case Definition for Reporting to OIE Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Isolation of MERS coronavirus from a dromedary camel Cross-sectional survey and surveillance for influenza viruses and MERS-CoV among Egyptian pilgrims returning from Hajj during 2012-2015 Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Specific serology for emerging human coronaviruses by protein microarray Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Serologic evidence for MERS-CoV infection in dromedary camels Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Development and validation of a rapid immunochromatographic assay for detection of Middle East respiratory syndrome coronavirus antigen in dromedary camels State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Influenza Aerosols in UK Hospitals during the H1N1 (2009) Pandemic -the Risk of Aerosol Generation during Medical Procedures Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions High prevalence of Middle East respiratory coronavirus in young dromedary camels in Jordan. Surveillance and testing for Middle East respiratory syndrome coronavirus, Saudi Arabia Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Response to emergence of Middle East respiratory syndrome coronavirus Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Acute respiratory infections among returning Hajj pilgrims-Jordan Infectious MERS-CoV isolated from a mildly Ill patient, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice Cross-sectional surveillance of Middle East R MERS-CoV) in dromedary camels and other mammals in Egypt Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt Association between Australian Hajj Pilgrims' awareness of MERS-CoV, and their compliance with preventive measures and exposure to camels Unusual presentation of Middle East respiratory syndrome coronavirus leading to a large outbreak in Riyadh during 2017 High prevalence of common respiratory viruses and no evidence of Middle East Respiratory Syndrome Coronavirus in Hajj pilgrims returning to Ghana Critically Ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study Middle East respiratory syndrome Corticosteroid therapy for critically Ill patients with Middle East respiratory syndrome Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Middle East respiratory syndrome coronavirus antibodies in dromedary camels Hospital outbreak of Middle East respiratory syndrome coronavirus Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travellers and pilgrims from the Middle East: a prospective descriptive study for the period 2013-2015 Evidence for camel-to-human transmission of MERS coronavirus Description of a hospital outbreak of Middle East respiratory syndrome in a large tertiary care hospital in Saudi Arabia Viral respiratory infections among Hajj pilgrims in 2013 Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Middle East respiratory syndrome coronavirus quasispecies that include homologues of human Isolates revealed through wholegenome analysis and virus cultured from dromedary camels in Saudi Arabia Geographic distribution of MERS coronavirus among dromedary camels MERS-CoV infection of alpaca in a region where MERS-CoV is endemic MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Antibodies against MERS coronavirus in dromedary camels Experimental infection and response to rechallenge of alpacas with Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus specific antibodies in naturally exposed Israeli llamas, alpacas and camels Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Transmission of MERS-coronavirus in household contacts An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia Toward developing a preventive MERS-CoV vaccine-report from a workshop organized by the Saudi Arabia Ministry of health and the international vaccine Institute Dromedary camels in northern Mali have high seropositivity to MERS-CoV FAO, 2014. keywords: camels; coronavirus; cov; east; et al; health; human; mers; middle; middle east; syndrome; transmission cache: cord-332952-d5l60cgc.txt plain text: cord-332952-d5l60cgc.txt item: #407 of 515 id: cord-333144-gyuh2fvl author: Siddiqui, Arif Jamal title: Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2 date: 2020-08-05 words: 7810 flesch: 40 summary: This combination is already in use with phase III clinical trials underway (Andreani et al., 2020b; Gautret et al., 2020b) . Three FDA-approved broad-spectrum inhibitors (chlorpromazine, chloroquine, toremifene) that were shown to be effective against MERS-CoV infection in immortalized cell lines and evaluated their antiviral activities (Cong et al., 2018) . keywords: antiviral; combination; coronavirus; cov-2; covid-19; disease; drug; et al; hcq; infection; mers; patients; sars; treatment; trials; use cache: cord-333144-gyuh2fvl.txt plain text: cord-333144-gyuh2fvl.txt item: #408 of 515 id: cord-333606-5z3kumu9 author: Lee, SangJoon title: Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines date: 2020-10-15 words: 1179 flesch: 33 summary: Among the proinflammatory cytokines, IL-1 Pyroptosis is an inflammasome-mediated form of inflammatory cell death [3] .  Specific CoV infections can activate inflammatory cell death (PANoptosis), thereby inducing cytokine release. keywords: cell; cov; infection; sars cache: cord-333606-5z3kumu9.txt plain text: cord-333606-5z3kumu9.txt item: #409 of 515 id: cord-333738-3xtb8gye author: Rabets, A. title: Development of antibodies to pan-coronavirus spike peptides in convalescent COVID-19 patients date: 2020-08-22 words: 2491 flesch: 42 summary: As can be seed from Figure 2c , the sera samples having shown stronger binding of IgG antibodies with anti-HR2 MERS spike protein also contained higher IgG reactivity towards anti-RBD spike protein of SARS-CoV-19. analysis of used MERS protein is showing similarity towards the sequence in the genome of SARS-CoV-19. keywords: cov-2; hr2; mers; preprint; protein; sars; spike cache: cord-333738-3xtb8gye.txt plain text: cord-333738-3xtb8gye.txt item: #410 of 515 id: cord-333882-zrdsr3nh author: Beigel, John H title: Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study date: 2018-04-30 words: 4895 flesch: 46 summary: After screening, study participants were enrolled sequentially in one of six cohorts. Study participants and study team members remained masked throughout the entire study. keywords: anti; cov; events; human; immunoglobulin; mers; participants; sab-301; study cache: cord-333882-zrdsr3nh.txt plain text: cord-333882-zrdsr3nh.txt item: #411 of 515 id: cord-334530-krclgmc4 author: Abroug, Fekri title: Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections, Tunisia, 2013 date: 2014-09-17 words: 1588 flesch: 50 summary: MERS-CoV summary and literature update-as of 31 Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission MERS coronavirus: data gaps for laboratory preparedness Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Early corticosteroids in severe influenza A/H1N1 pneumonia and acute respiratory distress syndrome Other MERS CoV patients who have died had concurrent conditions (2) , and corticosteroids are thought to worsen the outcomes for patients with influenza A(H1N1) virus infection (10) . keywords: coronavirus; cov; mers; patient; syndrome cache: cord-334530-krclgmc4.txt plain text: cord-334530-krclgmc4.txt item: #412 of 515 id: cord-334628-axon4jdc author: Lee, Saemi title: Genetic Characteristics of Coronaviruses from Korean Bats in 2016 date: 2017-07-19 words: 3233 flesch: 61 summary: In this study, bat samples (332 oral swabs, 245 fecal samples, 38 urine samples, and 57 bat carcasses) were collected at 33 natural bat habitat sites in South Korea. However, little research has been conducted on bat coronaviruses in South Korea. keywords: bat; bats; coronaviruses; cov; covs; samples; sars; sequences; species cache: cord-334628-axon4jdc.txt plain text: cord-334628-axon4jdc.txt item: #413 of 515 id: cord-334667-0cah15lg author: Arabi, Yaseen M. title: Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial date: 2020-01-03 words: 3838 flesch: 45 summary: To overcome these challenges, we designed the MIRACLE trial as a recursive two-stage adaptive trial, which is a relatively new method for group sequential trials The trial is designed as a recursive, two-stage, group sequential randomized trial. keywords: analysis; days; group; patients; stage; study; table; trial cache: cord-334667-0cah15lg.txt plain text: cord-334667-0cah15lg.txt item: #414 of 515 id: cord-334738-k6002qzb author: Shalhoub, S. title: MERS-CoV in a healthcare worker in Jeddah, Saudi Arabia: an index case investigation date: 2016-04-16 words: 2034 flesch: 53 summary: Given the absence of confirmed MERS cases in Jeddah at the time, an epidemiological index case investigation took place. Patient B was transferred to a designated hospital to manage confirmed MERS cases and was then transferred back to the primary hospital after being cleared for MERS-CoV. keywords: cov; mers; negative; patient; samples; september cache: cord-334738-k6002qzb.txt plain text: cord-334738-k6002qzb.txt item: #415 of 515 id: cord-334960-l5q5wc06 author: Park, Su Eun title: Epidemiology, virology, and clinical features of severe acute respiratory syndrome -coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19) date: 2020-04-02 words: 3767 flesch: 52 summary: Summary of probable SARS cases with onset of illness from 1 World Health Organization Severe acute respiratory syndrome (SARS) Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia World Health Organization. It is notable that SARS-CoV infection was not declared a pandemic despite of 8,096 confirmed cases leading to 774 deaths during the 8-month period since the first report of SARS case on November 16, 2002 . keywords: coronavirus; cov; cov-2; covid-19; pneumonia; sars; syndrome; transmission cache: cord-334960-l5q5wc06.txt plain text: cord-334960-l5q5wc06.txt item: #416 of 515 id: cord-335567-ssnvr6nj author: Berry, Michael title: Identification of New Respiratory Viruses in the New Millennium date: 2015-03-06 words: 7487 flesch: 33 summary: Between 7% and 19% of all cases of respiratory infections in children are caused by hMPV, in both hospitalized and outpatients [108, 131, 132] and has been reported to be the second most frequently identified virus in respiratory tract infections [133] . Viral upper respiratory tract infection and otitis media complication in young children The economic burden of non-influenza-related viral respiratory tract infection in the United States The clinical impact of human respiratory virus infections The Global Burden of Disease Center for Population and Development Studies: Massachusetts Serious bacterial infections in febrile infants 1 to 90 days old with and without viral infections Children with multiple viral respiratory infections are older than those with single viruses Systematic review of the treatment of upper respiratory tract infection Viral infections of the lower respiratory tract: Old viruses, new viruses, and the role of diagnosis Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong Human coronavirus and acute respiratory illness in older adults with chronic obstructive pulmonary disease Acute viral infections of upper respiratory tract in elderly people living in the community: Comparative, prospective, population based study of disease burden Respiratory viral infections in immunocompetent and immunocompromised persons Community respiratory virus infections in immunocompromised patients with cancer Epidemiology of respiratory viruses in bronchoalveolar lavage samples in a tertiary hospital Impact of viral infections in children with community-acquired pneumonia: keywords: acute; bocavirus; children; coronavirus; disease; hcov; human; infection; metapneumovirus; patients; sars; syndrome; tract; viruses cache: cord-335567-ssnvr6nj.txt plain text: cord-335567-ssnvr6nj.txt item: #417 of 515 id: cord-336150-l8w7xk0b author: Rathore, Jitendra Singh title: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a newly emerged pathogen: an overview date: 2020-08-25 words: 7378 flesch: 47 summary: Not so fast Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus Nitazoxanide has demonstrated potent in vitro activity against SARS CoV-2, with an EC 50 at 48 h of 2.12 μM in Vero E6 cells . keywords: ace2; bat; coronavirus; cov; cov-2; human; infection; mers; protein; rbd; receptor; sars; vaccine cache: cord-336150-l8w7xk0b.txt plain text: cord-336150-l8w7xk0b.txt item: #418 of 515 id: cord-336775-d4hi9myk author: Kirtipal, Nikhil title: From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses date: 2020-08-13 words: 8621 flesch: 29 summary: bat-SL-CoVZX45 and bat-SL-CoVZX2 from bats Zhou et al., 2020b) . (E), nucleocapsid (N) proteins, and hemagglutinin (HA), where S, M, and E proteins are embedded in viral envelop while N protein protects viral RNA genome located as core of virus ( Fig. 3 ) (Zhou et al., 2020b) . keywords: ace2; bats; cells; coronavirus; cov; cov-2; covs; et al; genome; host; human; immune; infection; mers; patients; protein; receptor; respiratory; responses; rna; sars; syndrome cache: cord-336775-d4hi9myk.txt plain text: cord-336775-d4hi9myk.txt item: #419 of 515 id: cord-337066-pztrwvib author: Choi, Won Suk title: Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea date: 2016-06-30 words: 3445 flesch: 44 summary: Asymptomatic patients were rare in this outbreak, presumably because confirmatory MERS-CoV tests were performed only for symptomatic patients, although active surveillance of asymptomatic HCWs involved in patient care was conducted at one hospital. The case fatality rate observed in this study was lower than that reported in other studies of previous MERS outbreaks (20.4% vs. 36.5-65%) keywords: cases; cov; infection; korea; mers; middle; outbreak; patients cache: cord-337066-pztrwvib.txt plain text: cord-337066-pztrwvib.txt item: #420 of 515 id: cord-337089-ksh62ni0 author: Salajegheh Tazerji, Sina title: Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to animals: an updated review date: 2020-09-21 words: 4909 flesch: 46 summary: 31 Department of Animal Wealth Development, Faculty of Veterinary Medicine Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A novel coronavirus outbreak of global health concern Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges A novel coronavirus emerging in China-key questions for impact assessment Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A The COVID-19 pandemic: a comprehensive review of taxonomy, genetics, epidemiology, diagnosis, treatment, and control Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus Emerging coronaviruses: genome structure, replication, and pathogenesis Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2 Epidemiology, genetic recombination, and pathogenesis of coronaviruses Coronavirus infection in equines: a review Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular immunity in rhesus macaques Emerging novel coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments Evolutionary trajectory for the emergence of novel coronavirus SARS-CoV-2 The Phyre2 web portal for protein modeling, prediction and analysis The proximal origin of SARS-CoV-2 Low-level of infection whit COVID-19 in pet dog Molecular basis of COVID-19 relationships in different species: a one health perspective Novel SARS-CoV-2/COVID-19: origin, pathogenesis, genes and genetic variations, immune responses and phylogenetic analysis World Health Organization WHO: summary table of SARS cases by country Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Bats are natural reservoirs of SARS-like coronaviruses SARS virus infection of cats and ferrets Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Middle East Although possible protection caused by the possession of a pet has not yet been found, the frequent occurrence of coronavirus in canines could help the human immune system develop a better response against SARS-CoV-2 [41] . keywords: animals; cats; coronavirus; cov-2; covid-19; humans; novel; protein; sars; spike; studies; transmission cache: cord-337089-ksh62ni0.txt plain text: cord-337089-ksh62ni0.txt item: #421 of 515 id: cord-337499-jzpgtkai author: Yong Choi, Sung title: Safe surgical tracheostomy during the COVID-19 pandemic: A protocol based on experiences with Middle East Respiratory Syndrome and COVID-19 outbreaks in South Korea date: 2020-06-17 words: 4737 flesch: 43 summary: Several studies related to guidelines or recommendations on surgical tracheostomy for COVID-19 patients have been published. Thus, we did not use a stay suture or Björk flap during surgical tracheostomy in MERS and COVID-19 patients. keywords: covid-19; icu; mers; outbreak; patients; ppe; protocol; tracheostomy; transmission cache: cord-337499-jzpgtkai.txt plain text: cord-337499-jzpgtkai.txt item: #422 of 515 id: cord-337825-ujq9mxk7 author: Chen, Bin title: Overview of lethal human coronaviruses date: 2020-06-10 words: 13457 flesch: 43 summary: lung injury Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14 +CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus Characterization of novel monoclonal antibodies against MERScoronavirus spike protein Discovery of hydrocarbon-stapled short α-helical peptides as promising Middle East respiratory syndrome coronavirus (MERS-CoV) fusion inhibitors A systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus (MERS-CoV) Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay Current treatment options and the role of peptides as potential therapeutic components for Middle East respiratory syndrome (MERS): a review Cell therapy in acute respiratory distress syndrome Challenges and responses in human vaccine development Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine Expression of B subunit of E. coli heat-labile enterotoxin in the progenies of transgenic tobacco bred by crossing nuclear-and chloroplast-transgenic lines Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice One-Health: a safe, efficient, dual-use vaccine for humans and animals against Middle East respiratory syndrome coronavirus and rabies virus Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation DNA vaccine of SARS-Cov S gene induces antibody response in mice ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments-the importance of immunofocusing in subunit vaccine design Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Disulfiram can inhibit MERS and SARS coronaviruspapain-like proteases via different modes De novo design of α-helical lipopeptides targeting viral fusion proteins: a promising strategy for relatively broad-spectrum antiviral drug discovery Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor New vaccine technologies to combat outbreak situations Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial Potent binding of 2019 novelcoronavirus spike protein by a SARS coronavirus-specific human monoclonalantibody Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies Exceptionally potent neutralizationof Middle East respiratory syndrome coronavirus by human monoclonalantibodies Interaction between heptad repeat 1 and 2 regions inspike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Fusion mechanism of 2019-nCoV andfusion inhibitors targeting HR1 domain in spike protein The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 31870836), and the 1.3.5 Project for Disciplines Excellence, West China Hospital, Sichuan University (ZYYC20005 to W.C.). Epidemiology, genetic recombination, and pathogenesis of coronaviruses Origins and evolution of the global RNA virome Classify viruses-the gain is worth the pain Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease Human coronaviruses: what do they cause? Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS A pneumonia outbreak associated with a new coronavirus of probable bat origin Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV On the origin and continuing evolution of SARS-CoV-2 Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Mutations, recombination and insertion in the evolution of 2019-nCoV SARS and MERS: recent insights into emerging coronaviruses Global epidemiology of bat coronaviruses From SARS to MERS, thrusting coronaviruses into the spotlight Challenges presented by MERS corona virus, and SARS corona virus to global health Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease MERS-CoV as an emerging respiratory illness: a review of prevention methods The Middle East respiratory syndrome (MERS) keywords: ace2; acute; antibodies; binding; cells; coronavirus; cov; cov-2; domain; east; gene; host; human; infection; mers; middle; novel; patients; protein; receptor; s protein; sars; spike; syndrome; syndrome coronavirus; type; vaccine; viruses cache: cord-337825-ujq9mxk7.txt plain text: cord-337825-ujq9mxk7.txt item: #423 of 515 id: cord-337835-78i6j11i author: Alfaraj, Sarah H. title: The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus date: 2017-02-09 words: 1534 flesch: 56 summary: 6 Only a small number of MERS cases had co-infection with influenza A, parainfluenza, herpes simplex, and Streptococcus pneumoniae. He denied history of travel or contact with positive case or camels. keywords: case; cov; infection; influenza; mers cache: cord-337835-78i6j11i.txt plain text: cord-337835-78i6j11i.txt item: #424 of 515 id: cord-338057-ycmr9prw author: Lee, Jae Hoon title: An Appropriate Lower Respiratory Tract Specimen Is Essential for Diagnosis of Middle East Respiratory Syndrome (MERS) date: 2015-07-15 words: 1319 flesch: 41 summary: Better understanding on MERS Corona virus outbreak in Korea Middle East respiratory syndome Information Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Pathogenesis of Middle East respiratory syndrome coronavirus An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities All patients in Korea acquired their disease in hospital settings where they came in direct or indirect contact with MERS patients. keywords: cov; mers; patients; respiratory cache: cord-338057-ycmr9prw.txt plain text: cord-338057-ycmr9prw.txt item: #425 of 515 id: cord-338436-0z828org author: Tzou, Philip L. title: Coronavirus Antiviral Research Database (CoV-RDB): An Online Database Designed to Facilitate Comparisons between Candidate Anti-Coronavirus Compounds date: 2020-09-09 words: 8207 flesch: 38 summary: Implications for disease pathogenesis and clinical manifestation Regulation of the Interferon System: Evidence that Vero Cells have a Genetic Defect in Interferon Production Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells: Nafamostat is the most potent antiviral drug candidate Characterization and treatment of SARS-CoV-2 in nasal and bronchial human airway epithelia Replication of SARS-CoV-2 in human respiratory epithelium Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Pneumonitis and Multi-Organ System Disease in Common Marmosets (Callithrix jacchus) Infected with the Severe Acute Respiratory Syndrome-Associated Coronavirus Animal models for SARS Animal models for SARS and MERS coronaviruses Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Cynomolgus macaque as an animal model for severe acute respiratory syndrome Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2 Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets Infection and Rapid Transmission of SARS-CoV-2 in Ferrets Pathogenesis and transmission of SARS-CoV-2 in golden hamsters The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 COVID-19 preclinical models: Human angiotensin-converting enzyme 2 transgenic mice Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset Type I and Type III Interferons-Induction, Signaling, Evasion, and Application to Combat COVID-19 SARS-CoV-2 sensitive to type I interferon pretreatment Coronavirus membrane fusion mechanism offers a potential target for antiviral development Coronaviruses -drug discovery and therapeutic options The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner. β-D-N4hydroxycytidine-5′isopropyl ester (EIDD-2801) EIDD-2801 is a nucleoside analog, which like remdesivir has high nanomolar inhibitory activity in vitro against SARS-CoV-2 [62] . keywords: activity; animal; antibodies; antiviral; cell; compounds; coronavirus; cov-2; covid-19; data; drug; experiments; human; sars; trials; virus cache: cord-338436-0z828org.txt plain text: cord-338436-0z828org.txt item: #426 of 515 id: cord-338538-uea9kwge author: Shehata, Mahmoud M. title: Bacterial Outer Membrane Vesicles (OMVs)-Based Dual Vaccine for Influenza A H1N1 Virus and MERS-CoV date: 2019-05-28 words: 6299 flesch: 41 summary: Therefore, OMVs vaccines may be used without extra adjuvant to increase the immunogenicity and produce antiviral innate immune responses against various influenza virus infections via activation of macrophages [42] [43] Therefore, OMVs vaccines may be used without extra adjuvant to increase the immunogenicity and produce antiviral innate immune responses against various influenza virus infections via activation of macrophages [42] [43] keywords: control; cov; figure; h1n1pdm2009; influenza; membrane; mers; mice; omvs; rbd; vaccine; virus cache: cord-338538-uea9kwge.txt plain text: cord-338538-uea9kwge.txt item: #427 of 515 id: cord-338564-68z2pxfz author: Kang, Min title: Contact Tracing for Imported Case of Middle East Respiratory Syndrome, China, 2015 date: 2016-09-17 words: 1509 flesch: 51 summary: Of the 110 contacts, 27 were air travel contacts (passengers onboard the same flight with the case-patient); 24 were land travel contacts (stewards and passengers taking the same buses with the case-patient); and 59 were community contacts (persons who had face-toface contact with the case-patient or who had direct contact with his belongings in hotels, restaurants, and a meeting room) Reviewing video helped trace 9 (38%) land travel contacts and 25 (42%) community contacts ( Table 2) . keywords: case; contacts; mers; patient cache: cord-338564-68z2pxfz.txt plain text: cord-338564-68z2pxfz.txt item: #428 of 515 id: cord-338776-2wa30218 author: Zhao, Xiaoyu title: Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages date: 2020-02-15 words: 4804 flesch: 34 summary: Taken together, in line with the observations from Mincle siRNA depletion, CLR receptor Mincle contributed to the immune activation in MERS-CoV-infected macrophages. We then performed a series of experiments to characterize the role of RLR and CLR, especially CLR, in MERS-CoV-infected macrophages, with the intention to better understand the pathogenesis of human MERS. keywords: cells; clr; cov; infection; macrophages; mers; mincle; response; rig; rlr; signaling cache: cord-338776-2wa30218.txt plain text: cord-338776-2wa30218.txt item: #429 of 515 id: cord-338973-73a7uvyz author: Xu, Jiabao title: Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV date: 2020-02-22 words: 7127 flesch: 54 summary: Nelfinavir was predicted to be a potential inhibitor of 2019 nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV A randomized, controlled trial of Ebola virus disease therapeutics First Case of 2019 Novel Coronavirus in the United States Research progress on novel coronavirus (2019-nCoV) related drugs in vitro/vivo Friendship Hospital: Clinical Experimental Research Work Is Being Carried Out on Remdesivir Recombination in large RNA viruses Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes Jumping species-A mechanism for coronavirus persistence and survival Serological evidence of bat SARS-related coronavirus infection in humans Clinical virology and pathogenesis Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: Relation to the acute lung injury and pathogenesis of SARS Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Epidemic Update and Risk Assessment of 2019 Novel Coronavirus Return of the Coronavirus: 2019-nCoV. Viruses Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients Middle East respiratory syndrome: Emergence of a pathogenic human coronavirus Diagnosis and Treatment of Pneumonia Caused by 2019-nCoV (Trial Version 4) Pulmonary rehabilitation guidelines in the principle of 4S for patients infected with 2019 novel coronavirus (2019-nCoV) Incubation periods of acute respiratory viral infections: A systematic review Multiple contact dates and SARS incubation periods A novel coronavirus from patients with pneumonia in China A novel coronavirus outbreak of global health concern The severe acute respiratory syndrome The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: An analysis of all 1755 patients Infectious Disease Expert Li Lanjuan Responded to Six Questions of 2019-nCoV Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Clinical features of patients infected with 2019 novel coronavirus in Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Press Conference of the National Health Commission of the People's Republic of China on 3 Intraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans Novel coronavirus: From discovery to clinical diagnostics SARS-CoV infection in a restaurant from palm civet Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human Pangolin May Be a Potential Intermediate Host of New Coronavirus. keywords: cases; china; coronavirus; cov; cov-2; covid-19; disease; human; mers; patients; pneumonia; protein; sars; severe cache: cord-338973-73a7uvyz.txt plain text: cord-338973-73a7uvyz.txt item: #430 of 515 id: cord-338980-pygykil7 author: Rahaman, Jordon title: Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses date: 2016-11-09 words: 5807 flesch: 45 summary: (C) NSP14, based on PDB id 5C8T A computationally optimized broadly reactive antigen (COBRA) based H5N1 VLP vaccine elicits broadly reactive antibodies in mice and ferrets Computationally optimized antigens to overcome influenza viral diversity Rapid evolution of virus sequences in intrinsically disordered protein regions Molecular pathology of emerging coronavirus infections MRBAYES: Bayesian inference of phylogenetic trees ETE 3: Reconstruction, analysis, and visualization of phylogenomic data Virus taxonomy: classification and nomenclature of viruses: Ninth Report of the International Committee on Taxonomy of Viruses The rapid generation of mutation data matrices from protein sequences MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform Minimization of genetic distances by the consensus, ancestral, and center-of-tree (COT) sequences for HIV-1 variants within an infected individual and the design of reagents to test immune reactivity Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses Bayesian model of protein primary sequence for secondary structure prediction Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex Comparison of site-specific rate-inference methods for protein sequences: empirical Bayesian methods are superior An evaluation of phylogenetic methods for reconstructing transmitted HIV variants using longitudinal clonal HIV sequence data The PSIPRED protein structure prediction server Metagenomics and future perspectives in virus discovery Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses Marked variability in the extent of protein disorder within and between viral families Cross host transmission in the emergence of MERS coronavirus MrBayes 3: Bayesian phylogenetic inference under mixed models Exploring the viral world through metagenomics The evolution of protein structures and structural Ensembles under functional constraint The challenge of protein structure determination-lessons from structural genomics Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human Epidemiology, genetic recombination, and pathogenesis of coronaviruses Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans The DISOPRED server for the prediction of protein disorder Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5 World Health Organization. Protein sequences were identified by individual BLAST searches with MERS-CoV (Taxonomy ID: 1335626) proteins ORF1ab (YP_009047202.1; polyprotein), S protein (YP_009047204.1), M protein (YP_009047210.1), E protein (YP_009047209.1), and N protein (YP_009047211.1) against coronaviruses. keywords: coronaviruses; cov; disorder; et al; mers; protein; regions; sequence; sites; structure cache: cord-338980-pygykil7.txt plain text: cord-338980-pygykil7.txt item: #431 of 515 id: cord-339146-ifdgl2bj author: Lu, Xiaoyan title: Spike gene deletion quasispecies in serum of patient with acute MERS‐CoV infection date: 2016-08-22 words: 2206 flesch: 42 summary: [Assiri et al., 2016a] and the paucity of other reports of MERS-CoV spike gene deletions suggest that this event is rare and not of deliberate design. Although most spike gene deletion mutations have been found in the S1 region, some studies have also documented mutations in the S2 region with similar effects. keywords: coronavirus; cov; mers; protein; spike; virus cache: cord-339146-ifdgl2bj.txt plain text: cord-339146-ifdgl2bj.txt item: #432 of 515 id: cord-339152-wfakzb6w author: Trovato, Maria title: Viral Emerging Diseases: Challenges in Developing Vaccination Strategies date: 2020-09-03 words: 12011 flesch: 23 summary: United States patent US 20120141520 Advanced oxidation technology for the development of a next-generation inactivated West Nile virus vaccine Replication-defective West Nile virus with NS1 deletion as a new vaccine platform for flavivirus Zika virus associated with microcephaly A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models A vaccine based on a modified vaccinia virus Ankara vector expressing Zika virus structural proteins controls Zika virus replication in mice Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Preventative vaccines for Zika virus outbreak: preliminary evaluation Recent advances in Zika virus vaccines Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it Live attenuated yellow fever 17D vaccine: a legacy vaccine still controlling outbreaks in modern day Development of Sanofi Pasteur tetravalent dengue vaccine From research to phase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine Pathogenesis of dengue: challenges to molecular biology Antibody-dependent enhancement of severe dengue disease in humans Dengue: status of current and under-development vaccines Immunogenicity, safety, and tolerability of the measles-vectored chikungunya virus vaccine MV-CHIK: a double-blind, randomised, placebo-controlled and active-controlled phase 2 trial Recent progress in vaccine development against Chikungunya virus Effective vaccine for lassa fever Vaccine platforms for the prevention of Lassa fever Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot Isolation of marburg-like virus from a case of haemorrhagic fever in Zaire Vaccines against Ebola virus A review of Phase I trials of Ebola virus vaccines: what can we learn from the race to develop novel vaccines Viruslike particle vaccination protects nonhuman primates from lethal aerosol exposure with marburgvirus (VLP Vaccination Protects Macaques against Aerosol Challenges) Studies for the development of a safer vaccine are still ongoing, and candidate vaccines include a tetravalent Dengue purified inactivated virus vaccine, currently in phase I/II clinical trial (NCT02421367), and two live attenuated tetravalent chimeric TDV (DENVax), and keywords: antibodies; antibody; cell; coronavirus; cov-2; dengue; development; diseases; human; immunity; infection; influenza; mers; new; outbreak; protein; receptor; recombinant; responses; sars; vaccination; vaccine; vector; virus; viruses cache: cord-339152-wfakzb6w.txt plain text: cord-339152-wfakzb6w.txt item: #433 of 515 id: cord-339386-sxyeuiw1 author: McIntosh, Kenneth title: 157 Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) date: 2015-12-31 words: 8508 flesch: 39 summary: Berlin Diarrhea/Wasting Syndrome Study Group Coronaviruslike particles and other agents in the faeces of children in Efate, Vanuatu Coronavirus-like particles in adults in Melbourne, Australia Coronaviruslike particles in human gastrointestinal disease: epidemiologic, clinical, and laboratory observations An eight-year study of the viral agents of acute gastroenteritis in humans: ultrastructural observations and seasonal distribution with a major emphasis on coronavirus-like particles Isolation and characterization of current human coronavirus strains in primary human epithelia cultures reveals differences in target cell tropism Ultrastructure of human nasal epithelium during an episode of coronavirus infection Signs and symptoms in common colds Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis Clinical progression and viral load in a community outbreak of coronavirusassociated SARS pneumonia: a prospective study Detection of SARS-CoV RNA in stool samples of SARS patients by nest RT-PCR and its clinical value A major outbreak of severe acute respiratory syndrome in Hong Kong Lung pathology of fatal severe acute respiratory syndrome The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Multiple organ infection and the pathogenesis of SARS Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS Antigenic relationships amongst coronaviruses A case-control study of acute respiratory tract infection in general practice patients in The Netherlands Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study Coronavirus infection in acute lower respiratory tract disease of infants Genetic variability of human coronavirus OC43-, 229E-, and NL63-like strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children Recurrent wheezy bronchitis and viral respiratory infections Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction Coronavirus infections in military recruits: three-year study with coronavirus strains OC43 and 229E Respiratory viruses and exacerbations of asthma in adults Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity Rhinovirus and coronavirus infection-associated hospitalizations among older adults A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection Coronavirus 229E-related pneumonia in immunocompromised patients Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant Clinical impact of human coronaviruses 229E and OC43 infection in diverse adult populations The United Kingdom public health response to an Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV World Health Organization. Experience in a regional hospital in Hong Kong Severe acute respiratory syndrome among children Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients Imaging of severe acute respiratory syndrome in Hong Kong Severe acute respiratory syndrome: radiographic and CT findings Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Critically ill patients with severe acute respiratory syndrome Clinical presentations and outcome of severe acute respiratory syndrome in children Severe acute respiratory syndrome and pregnancy Viral discovery and sequence recovery using DNA microarrays Corona virus induced subacute demyelinating encephalomyelitis in rats: a morphological analysis Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients Detection of coronavirus RNA and antigen in multiple sclerosis brain Human coronavirus gene expression in the brains of multiple sclerosis patients Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis Diagnosis of human coronavirus infection by immunofluorescence: method and application to respiratory disease in hospitalized children Surveillance of community-acquired viral infections due to respiratory viruses in Rhone-Alpes (France) during winter 1994 to 1995 Clinical disease in children associated with newly described coronavirus subtypes Detection of a novel human coronavirus by real-time reversetranscription polymerase chain reaction Development of a standard treatment protocol for severe acute respiratory syndrome Treatment and vaccines for severe acute respiratory syndrome SARS: systematic review of treatment effects Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential Human cell tropism and innate immune system interactions of human respiratory coronavirus EMC compared to those of severe acute respiratory syndrome coronavirus The spike protein of SARS-CoVa target for vaccine and therapeutic development keywords: children; coronavirus; cov; covs; disease; hcov; human; infection; mers; oc43; patients; respiratory; sars; severe; syndrome; syndrome coronavirus; viruses cache: cord-339386-sxyeuiw1.txt plain text: cord-339386-sxyeuiw1.txt item: #434 of 515 id: cord-339724-roj8ksvc author: Lan, Jiaming title: Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an Antigen date: 2014-11-18 words: 5043 flesch: 45 summary: On the other hand, Th2 antibody responses can be induced by the Alum, as indicated by increased IgG1 relative to IgG2a The induction of a robust humoral, including potent neutralizing antibodies, and cellular immune response is likely essential for immediate and sustained protective immunity in a MERS-CoV vaccine design. keywords: adjuvant; antibody; cov; i+c; mers; mice; protein; rbd; regimes; response; vaccination; vaccine cache: cord-339724-roj8ksvc.txt plain text: cord-339724-roj8ksvc.txt item: #435 of 515 id: cord-339762-lh8czr0a author: Ng, Dianna L. title: Clinicopathologic, Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates, April 2014 date: 2016-03-31 words: 3211 flesch: 31 summary: Lit Update Risk Assess 7 Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Albarrak AM: Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Al Raiy B: Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Evaluation of pigtail macaques as a model for the effects of copper intrauterine devices on HIV infection Pathology and pathogenesis of fatal Bordetella pertussis infection in infants Fullgenome deep sequencing and phylogenetic analysis of novel human betacoronavirus MRBAYES: Bayesian inference of phylogenetic trees Realtime reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Time course and cellular localization of SARS-CoV nucleoprotein and RNA in lungs from fatal cases of SARS Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an invitro and ex-vivo study Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Clinical management of severe acute respiratory infection when Middle East respiratory syndrome coronavirus (MERS-CoV) infection is suspected. keywords: cells; coronavirus; cov; east; infection; mers; middle; pneumocytes; syndrome cache: cord-339762-lh8czr0a.txt plain text: cord-339762-lh8czr0a.txt item: #436 of 515 id: cord-340163-ex03l0pc author: Hu, Tingting title: A comparison of COVID-19, SARS and MERS date: 2020-08-19 words: 7925 flesch: 43 summary: From SARS to MERS: evidence and speculation Rigidity of the outer shell predicted by a protein intrinsic disorder model sheds light on the COVID-19 (Wuhan-2019-nCoV) infectivity Nucleic acid detection with CRISPR-Cas13a/C2c2 Severe acute respiratory syndrome: global initiatives for disease diagnosis Multiple organ infection and the pathogenesis of SARS Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus: a first step in understanding SARS pathogenesis Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection First case of 2019 novel coronavirus in the United States Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus Clinical features of patients infected with 2019 novel coronavirus in Wuhan Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations Neurologic manifestations of hospitalized patients with coronavirus disease Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction Emerging infections-implications for dental care Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome Lung pathology of fatal severe acute respiratory syndrome Viral load kinetics of MERS coronavirus infection Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study SARS: radiological features Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China Emerging respiratory infections threatening public health in the Asia-Pacific region: a position paper of the Asian Pacific society of respirology Radiologic pattern of disease in patients with severe acute respiratory syndrome: the Toronto experience Coronavirus infections-more than just the common cold Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Coronaviruses post-SARS: update on replication and pathogenesis Recent trends in soft-tissue infection imaging Pulmonary embolism in patients with COVID-19: awareness of an increased prevalence Early diagnosis of SARS coronavirus infection by real time RT-PCR Identification of severe acute respiratory syndrome in Canada Cell-based therapy to reduce mortality from COVID-19: systematic review and meta-analysis of human studies on acute respiratory distress syndrome Liver-targeted angiotensin converting enzyme 2 therapy inhibits chronic biliary fibrosis in multiple drug-resistant gene 2-knockout mice Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York city area Characterization of a novel coronavirus associated with severe acute respiratory syndrome The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak Ang II (Angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (Prolyloligopeptidase)-dependent and ACE2 (Angiotensin-converting enzyme 2)-independent Characteristics and diagnosis rate of 5630 subjects receiving SARS-CoV-2 nucleic acid tests from Wuhan SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes Development of fluorescent reverse transcription loop-mediated isothermal amplification (RT-LAMP) using quenching probes for the detection of the Middle East respiratory syndrome coronavirus ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis ACE2 and ACE in acute and chronic rejection after human heart transplantation SARS: systematic review of treatment effects Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Knowledge synthesis of 100 million biomedical documents augments the deep expression profiling of coronavirus receptors Value of autopsy emphasized in the case report of a single patient with Middle East respiratory syndrome Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Rapid and sensitive detection of severe acute respiratory syndrome coronavirus by rolling circle amplification Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 Plain radiograph and CT features of 112 patients with SARS in acute stage World Health Organization (WHO). The fibrosis and consolidation in the lungs of SARS patients are more serious than the lesions caused by COVID-19, which indicates that the chest lesions are not primarily serous inflammation; instead, the exudative reaction of SARS is less than that of COVID-19. keywords: ace2; cells; coronavirus; cov; cov-2; covid-19; cxr; disease; et al; findings; lung; mers; patients; pneumonia; sars; studies; syndrome cache: cord-340163-ex03l0pc.txt plain text: cord-340163-ex03l0pc.txt item: #437 of 515 id: cord-340836-eb5a9ln3 author: Aghazadeh-Attari, Javad title: Epidemiological factors and worldwide pattern of Middle East respiratory syndrome coronavirus from 2013 to 2016 date: 2018-04-06 words: 2695 flesch: 46 summary: In summary, these findings point to interesting and potential dimensions of the dynamic evolution of this disease, and the need for further studies on genetic features of the culprit virus and the epidemiological parameters and risk factors of MERS-CoV mortality is also emphasized. Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Person-to-person spread of the MERS coronavirus-an evolving picture Evidence for camel-to-human transmission of MERS coronavirus Evidence for camel-to-human transmission of MERS coronavirus This work was funded by the Urmia University of Medical Sciences (grant number 2122). keywords: cases; cov; disease; factors; infection; mers cache: cord-340836-eb5a9ln3.txt plain text: cord-340836-eb5a9ln3.txt item: #438 of 515 id: cord-341056-iwu428pk author: Alnaeem, Abdelmohsen title: The dipeptidyl peptidase-4 expression in some MERS-CoV naturally infected dromedary camels in Saudi Arabia 2018–2019 date: 2020-05-06 words: 1774 flesch: 46 summary: Middle East respiratory syndrome coronavirus (MERS-CoV)-The Kingdom of Saudi Arabia Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with middle east respiratory syndrome coronavirus DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection Co-localization of Middle East respiratory syndrome coronavirus (MERS-CoV) and dipeptidyl peptidase-4 in the respiratory tract and lymphoid tissues of pigs and llamas Experimental infection of dromedaries with Middle East respiratory syndrome-Coronavirus is accompanied by massive ciliary loss and depletion of the cell surface receptor dipeptidyl peptidase 4 Species-specific colocalization of middle east respiratory syndrome coronavirus attachment and entry receptors The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models A comparative review of animal models of Middle East respiratory syndrome coronavirus infection Infection with MERS-CoV causes lethal pneumonia in the common marmoset Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection MERS-CoV infection of alpaca in a region where MERS-CoV is endemic Acknowledgements We wish to thank the King Abdul-Aziz City for Science and Technology (KACST) for their generous funding through the MERS-CoV research grant program (Number 20-0004), which is a part of the Targeted Research Program (TRP). key: cord-341056-iwu428pk authors: Alnaeem, Abdelmohsen; Kasem, Samy; Qasim, Ibrahim; Al-Doweriej, Ali; Refaat, Mohamed; Al-Shabebi, Abdulkareem; Hemida, Maged Gomaa title: The dipeptidyl peptidase-4 expression in some MERS-CoV naturally infected dromedary camels in Saudi Arabia 2018–2019 date: 2020-05-06 journal: Virusdisease DOI: 10.1007/s13337-020-00586-y sha: doc_id: 341056 cord_uid: iwu428pk MERS-CoV usually causes respiratory and renal failure in some patients, which may be the underlying cause of death. keywords: camels; cov; dromedary; infection; mers cache: cord-341056-iwu428pk.txt plain text: cord-341056-iwu428pk.txt item: #439 of 515 id: cord-341620-nmrkhx5t author: Chirico, Francesco title: Can Air-Conditioning Systems Contribute to the Spread of SARS/MERS/COVID-19 Infection? Insights from a Rapid Review of the Literature date: 2020-08-20 words: 4579 flesch: 39 summary: Revisiting the largest nosocomial severe acute respiratory syndrome outbreak in Hong Kong Role of air distribution in SARS transmission during the largest nosocomial outbreak in Hong Kong Evidence of airborne transmission of the severe acute respiratory syndrome virus Multi-zone modeling of probable SARS virus transmission by airflow between flats in Block E Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS isolation wards Indoor transmission of SARS-CoV-2. The air exchange owing to temperature difference played a significant role in SARS transmission during the nosocomial outbreak in Ward 8A, and the two-way airflow effect at the openings could have played an important role in bioaerosol transmission keywords: air; conditioning; coronavirus; cov-2; covid-19; hvac; outbreak; sars; studies; systems; transmission cache: cord-341620-nmrkhx5t.txt plain text: cord-341620-nmrkhx5t.txt item: #440 of 515 id: cord-341698-k5leys8j author: Park, Seung Won title: Avoiding student infection during a Middle East respiratory syndrome (MERS) outbreak: a single medical school experience date: 2016-05-27 words: 1269 flesch: 42 summary: In outbreaks of infectious disease, medical students are easily overlooked in the management of healthcare personnel protection although they serve in clinical clerkships in hospitals. Due to their participation in clinical clerkships, medical students should be considered to be at-risk HCP during infectious disease outbreaks. keywords: disease; medical; school; students cache: cord-341698-k5leys8j.txt plain text: cord-341698-k5leys8j.txt item: #441 of 515 id: cord-341795-zbqfs77n author: Sikkema, R. S. title: Global status of Middle East respiratory syndrome coronavirus in dromedary camels: a systematic review date: 2019-02-21 words: 5008 flesch: 51 summary: The publications in this review show that the MERS-CoV mainly circulates in dromedary camel populations in the Middle East and part of Africa, and has been infecting dromedary camels in Africa for more than three decades. In total, 33 papers describe camel studies in the Middle East, 13 studies investigated camels from Africa and the remaining seven surveys were from Spain, Australia, Japan, Bangladesh and Pakistan (Table 1) . keywords: antibodies; camels; coronavirus; cov; east; mers; middle; studies; syndrome cache: cord-341795-zbqfs77n.txt plain text: cord-341795-zbqfs77n.txt item: #442 of 515 id: cord-342052-v4y1xc90 author: Horigan, Verity title: Application of a quantitative entry assessment model to compare the relative risk of incursion of zoonotic bat-borne viruses into European Union Member States date: 2017-10-02 words: 12805 flesch: 43 summary: Temporary loss of rabies free Certificate Experimental inoculation of plants and animals with Ebola virus Studies of reservoir hosts for Marburg virus Ebola virus disease in West Africa-the first 9 months of the epidemic and forward projections West African Ebola epidemic after one year-slowing but not yet under control Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA Response to imported case of Marburg hemorrhagic fever, the Netherlands Marburg virus infection detected in a common African bat Isolation of genetically diverse Marburg viruses from Egyptian fruit bats Trade control and expert system Pathology of experimental aerosol Zaire Ebolavirus infection in Rhesus macaques Highly pathogenic H5N1 influenza virus in smuggled Thai eagles Stability of Middle East Respiratory syndrome coronavirus in milk Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making Ebola Hemorrhagic fever associated with novel virus strain Transmission of Ebola virus from pigs to non-human primates Review of Ebola virus infections in domestic animals Case of Marburg haemorrhagic fever imported into the Netherlands from Uganda WHO. Ninth update ECDC, Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV) 21st update Incubation period of ebola hemorrhagic virus subtype zaire Statistics database Illegal import of bushmeat and other meat products into Switzerland on commercial passenger flights Infection with MERS-CoV causes lethal pneumonia in the common marmoset Trade data Phylogeographical footprint of colonial history in the global dispersal of human immunodeficiency virus type 2 group A Chains of transmission and control of Ebola virus disease in Conakry, Guinea, in 2014: an observational study Hendra virus infection dynamics in Australian fruit bats Lessons from nosocomial viral haemorrhagic fever outbreaks Henipavirus susceptibility to environmental variables European bat lyssaviruses: an emerging zoonosis Ebola hemorrhagic fever transmission and risk factors of contacts Outbreak of Marburg virus disease in Johannesburg Pathogenesis of Ebola hemorrhagic fever in Cynomolgus macaques -evidence that dendritic cells are early and sustained targets of infection Marburg virus Angola infection of rhesus macaques: pathogenesis and treatment with recombinant nematode anticoagulant protein c2 Collection of mammals and arthropods during the epidemic of haemorrhagic fever in Zaire D2R2: an evidencebased decision support tool to aid prioritisation of animal health issues for government funding Natural Hendra virus infection in flying-foxes -tissue tropism and risk factors Person-to-person transmission of Nipah virus in a Bangladeshi community Isolation of Hendra virus from Pteropid bats: a natural reservoir of Hendra virus Pteropid bats are confirmed as the reservoir hosts of Henipaviruses: a comprehensive experimental study of virus transmission Identification of likely natural hosts for equine morbillivirus Hendra virus infection in a veterinarian Long-term survival of an urban fruit bat seropositive for Ebola and Lagos bat viruses Demography of straw-colored fruit bats in Ghana Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Pathogenesis of Marburg hemorrhagic fever in Cynomolgus Macaques On the ecology of the fruit bat, rousettus aegyptiacus leachi (A. Smith, 1829) in the Tsitsikama Coastal National Park Four outbreaks of norovirus gastroenteritis after consuming raspberries The lesions of experimental equine morbillivirus disease in cats and guinea pigs Nipah situation in 2014 Immune and pathophysiological processes in baboons experimentally infected with Ebola virus adapted to guinea pigs Transmission of Ebola virus (Zaire strain) to uninfected control monkeys in a biocontainment laboratory Experimental infection of Cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 US epizootic Lethal experimental infections of Rhesus-monkeys by aerosolized Ebola-virus Characterization of a new Marburg virus isolated from a 1987 fatal case in Kenya A randomized controlled trial of interventions to impede date palm sap contamination by bats to prevent Nipah virus transmission in Bangladesh Marburg virus Replication, pathogenicity, shedding, and transmission of Zaire Ebolavirus in Pigs Real-time monitoring of cardiovascular function in Rhesus macaques infected with Zaire Ebolavirus Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae Hendra virus and horse owners -risk perception and management Marburg virus in fruit bat Hyspignathus monstrosus Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo: reflections on a vertebrate collection Statistical inference in a stochastic epidemic SEIR model with control intervention: Ebola as a case study Fruit bats as reservoirs of Ebola virus Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo Dissemination of Cefotaxime-M-Producing Escherichia coli isolates in poultry farms, but not swine farms, in China Experimental inoculation study indicates swine as a potential host for Hendra virus Foodborne transmission of Nipah virus Proportion of deaths and clinical features in Bundibugyo Ebola virus infection Biosecurity Authority, Ministry of Agriculture and Forestry Is Marburg virus enzootic in Gabon? keywords: bats; bushmeat; cov; data; ebola; ebov; et al; human; infection; introduction; mers; model; number; prevalence; probability; risk; routes; tcid; trade; transmission; virus; viruses cache: cord-342052-v4y1xc90.txt plain text: cord-342052-v4y1xc90.txt item: #443 of 515 id: cord-342144-awtiqxx5 author: Hufert, F. title: Coronaviren: von der banalen Erkältung zum schweren Lungenversagen: Chronologie einer Pandemie date: 2020-04-01 words: 3321 flesch: 40 summary: key: cord-342144-awtiqxx5 authors: Hufert, F.; Spiegel, M. title: Coronaviren: von der banalen Erkältung zum schweren Die Erkrankung, die das Virus auslöst, erhielt von der World Health Organization (WHO) den Namen coronavirus disease 2019 (CO-VID-19). keywords: als; auch; auf; bei; coronavirus; cov; cov-2; covid-19; das; dass; der; des; die; disease; eine; für; ist; mers; mit; novel; sars; sich; sind; und; von; werden cache: cord-342144-awtiqxx5.txt plain text: cord-342144-awtiqxx5.txt item: #444 of 515 id: cord-342691-8jcfzexy author: Ochsner, Scott A. title: Consensus transcriptional regulatory networks of coronavirus-infected human cells date: 2020-09-22 words: 10456 flesch: 32 summary: Per FAIR data best practice, CoV infection datasets -like all SPP datasetsare associated with detailed descriptions, assigned a DOI, and linked to the associated article to place the dataset in its original experimental context (Fig. 9D) . Like all SPP datasets, CoV infection datasets are comprehensively aligned with FAIR data best practice and feature human-readable names and descriptions, a DOI, one-click addition to citation managers, and machine-readable downloadable data files. keywords: cell; consensomes; cov; cov infection; data; fig; genes; hcts; human; iav; infection; intersection; mers; node; pathway; response; sars2; signaling; spp; transcriptional; values cache: cord-342691-8jcfzexy.txt plain text: cord-342691-8jcfzexy.txt item: #445 of 515 id: cord-342739-iy9vjpuh author: Schwartz, David A. title: Potential Maternal and Infant Outcomes from Coronavirus 2019-nCoV (SARS-CoV-2) Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections date: 2020-02-10 words: 8446 flesch: 46 summary: However, even if this is the case, there is no doubt that SARS coronavirus infection was found to be associated with severe maternal illness, maternal death, and spontaneous abortion [19, [28] [29] Renal failure (P = 0.006) and disseminated intravascular coagulopathy (P = 0.006) developed more frequently in pregnant SARS patients when compared with the non-pregnant SARS group. keywords: cases; coronavirus; cov; epidemic; health; infection; mers; patients; pneumonia; pregnancy; respiratory; sars; syndrome; women cache: cord-342739-iy9vjpuh.txt plain text: cord-342739-iy9vjpuh.txt item: #446 of 515 id: cord-342756-rgm9ffpk author: Senger, Mario Roberto title: COVID-19: molecular targets, drug repurposing and new avenues for drug discovery date: 2020-10-02 words: 16157 flesch: 39 summary: Structure-based virtual screening and molecular dynamics simulation of SARS-CoV-2 Guanine-N7 methyltransferase (nsp14) for identifying antiviral inhibitors against COVID-19 Virtual screening, ADME/T, and binding free energy analysis of anti-viral, anti-protease, and anti-infectious compounds against NSP10/ NSP16 methyltransferase and main protease of SARS CoV-2 Targeting SARS-COV-2 non-structural protein 16: a virtual drug repurposing study Ready, set, fuse! (148) Other targets -Apart from SARS-CoVs infection, some relevant molecular targets of other viral diseases and host metabolism have also been investigated in COVID-19 drug discovery, such as viral neuraminidases and the DPP4 cell receptor. keywords: ace2; activity; cells; coronavirus; cov-2; covid-19; disease; drug; fig; host; human; infection; inhibitors; lopinavir; mers; new; patent; patients; potential; protease; protein; remdesivir; replication; repurposing; ritonavir; rna; sars; structure; studies; syndrome; target; treatment; trials cache: cord-342756-rgm9ffpk.txt plain text: cord-342756-rgm9ffpk.txt item: #447 of 515 id: cord-343107-oj1re34k author: Zhou, Haixia title: Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spike glycoprotein date: 2019-07-11 words: 8683 flesch: 45 summary: It indicated that the combination of 7D10 with MERS-27 exhibited neither synergy nor antagonism. Mechanism of 7D10 neutralization. Here, we showed that 7D10 neutralization is not solely dependent on DPP4-binding competition, and its inhibition of the S trimer conformational transition after cell attachment also plays a significant role in the neutralization. keywords: 7d10; antibodies; binding; cov; dpp4; fig; mers; neutralization; neutralizing; ntd; rbd; receptor; residues; scfv; spike; supplementary; trimer cache: cord-343107-oj1re34k.txt plain text: cord-343107-oj1re34k.txt item: #448 of 515 id: cord-343184-kptkmgdm author: Crameri, Gary title: Experimental Infection and Response to Rechallenge of Alpacas with Middle East Respiratory Syndrome Coronavirus date: 2016-06-17 words: 1610 flesch: 40 summary: Experimental Infection of Alpacas with MERS-CoV Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Inactivation and safety testing of Middle East respiratory syndrome coronavirus Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health MERS coronavirus in dromedary camel herd, Saudi Arabia Absence of MERS-CoV antibodies in feral camels in Australia: implications for the pathogen's origin and spread Replicative capacity of MERS coronavirus in livestock cell lines Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas We thank Kaylene Selleck, Leah Frazer, Jean Payne, Rachel Arkinstall, and Mahen Perera for providing technical assistance and support for this study. We found no previous MERS-CoV challenge trial reported in alpacas, so we chose a preliminary dose and rechallenge time on the basis of our experience with other virus infection trials for other emerging infectious diseases (8) . keywords: alpacas; cov; infection; mers; virus cache: cord-343184-kptkmgdm.txt plain text: cord-343184-kptkmgdm.txt item: #449 of 515 id: cord-343196-vlwzzrgc author: Kiambi, Stella title: Detection of distinct MERS-Coronavirus strains in dromedary camels from Kenya, 2017 date: 2018-11-28 words: 1496 flesch: 36 summary: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia MERS and the dromedary camel trade between Africa and the Middle East MERS coronaviruses from camels in Africa exhibit regiondependent genetic diversity Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt Antibodies against MERS coronavirus in dromedary camels MERS-CoV Antibodies in Humans Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Time Course of MERS-CoV Infection and Immunity in Dromedary Camels Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 MERS-CoV 4b protein interferes with the NF-kappaBdependent innate immune response during infection Middle East respiratory syndrome coronavirus accessory protein 4a is a type I interferon antagonist Transgene expression in the genome of Middle East respiratory syndrome coronavirus based on a novel reverse genetics system utilizing Redmediated recombination cloning The limited number of human MERS cases in Africa would certainly favor the idea that MERS-CoV strains differ in virulence and transmissibility. keywords: cov; mers; strains cache: cord-343196-vlwzzrgc.txt plain text: cord-343196-vlwzzrgc.txt item: #450 of 515 id: cord-343302-g9vcchrh author: Agrawal, Anurodh Shankar title: Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection date: 2016-08-19 words: 4820 flesch: 39 summary: The effect of m336 antibody treatment on the pulmonary pathology associated with MERS-CoV infection was evaluated by using formalin-fixed, paraffin embedded, and hematoxylin/eosin (H&E)-stained lung specimens harvested at day 2 p.i. We report in this study for the first time that treatment of Tg mice with a single-dose of m336 antibody prior to or after challenging with 1,000 LD 50 of MERS-CoV protected mice from the lethality in a dose-dependent manner, thereby representing the first antibody tested for its protective efficacy against lethal MERS-CoV infection. keywords: antibody; coronavirus; cov; human; infection; m336; mers; mice; middle; syndrome cache: cord-343302-g9vcchrh.txt plain text: cord-343302-g9vcchrh.txt item: #451 of 515 id: cord-343528-5283jsnu author: Zhang, Zhao title: Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission date: 2016-05-04 words: 4746 flesch: 49 summary: The initial 25% samples were discarded as burn-in, leaving 75% trees per run to produce the consensus tree Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group MERS coronavirus neutralizing antibodies in camels Antibodies against MERS coronavirus in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat MERS-related betacoronavirus in Vespertilio superans bats Characterization of a novel betacoronavirus related to middle East respiratory syndrome coronavirus in European hedgehogs Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Evidence for camel-to-human transmission of MERS coronavirus Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission Two Mutations were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus It is reasonable to speculate that MERS-CoV N protein under intensive selection because its functions were similar to those of SARS-CoV N protein. keywords: camel; coronavirus; cov; covs; human; mers; protein; recombination; sequences cache: cord-343528-5283jsnu.txt plain text: cord-343528-5283jsnu.txt item: #452 of 515 id: cord-343789-6tq0kcfd author: Al-Tawfiq, Jaffar A. title: Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study date: 2014-01-06 words: 2633 flesch: 55 summary: Taking stock of the first 133 MERS coronavirus cases globally-is the epidemic changing? Middle East respiratory syndrome coronavirus (MERS-CoV)-update Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study KSA MERS-CoV Investigation Team. Hospital outbreak of Middle East respiratory syndrome coronavirus Family cluster of Middle East respiratory syndrome coronavirus infections Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak Investigational use of ribavirin in the treatment of severe acute respiratory syndrome Identification of severe acute respiratory syndrome in Canada A cluster of cases of severe acute respiratory syndrome in Hong Kong Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a global patient registry Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Product Information: REBETOL (R) oral capsules solution, ribavirin oral capsules solution The authors (JAT, HM, and JD) wish to acknowledge the use of the Saudi Aramco Medical Services Organization (SAMSO) facilities for the data and study, which resulted in this paper. keywords: days; patients; ribavirin; therapy cache: cord-343789-6tq0kcfd.txt plain text: cord-343789-6tq0kcfd.txt item: #453 of 515 id: cord-344217-kci4uw7u author: Majid, Sabhiya title: Managing the COVID-19 Pandemic: Research Strategies Based on the Evolutionary and Molecular Characteristics of Coronaviruses date: 2020-08-25 words: 5657 flesch: 39 summary: mSphere Multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells Structure of SARS coronavirus spike receptor binding domain complexed with the receptor Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 The bittersweet promise of glycobiology The novel coronavirus2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Human coronavirus NL63employs the severe acute respiratory syndrome coronavirus receptor for cellular entry ACE2 of the heart: from angiotensin I to angiotensin (1-7) Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus COVID-19 infection: origin, transmission, and characteristics of human coronaviruses Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China The Association of Cardiovascular Diseases and Diabetes Mellitus with COVID-19 (SARS-CoV-2) and their possible mechanisms Crystal structure of NL63 respiratory coronavirus receptor-binding complexed with its human receptor Structural basis of receptor recognition by SARS-CoV-2 Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE Clinical management of adult coronavirus infection disease 2019 (COVID-19) positive in the setting of low and medium intensity of care: a short practical review Master regulator analysis of the SARS-CoV-2 /human interactome COVID-19 outbreak: an update on therapeutic options Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations SN Compr Clin Med Cryo-electron tomography of mouse hepatitis virus: insights into the structure of the coronavirion The molecular biology of coronaviruses Coronavirus: organization, replication and expression of genome Mechanisms and enzymes involved in SARS coronavirus genome expression Pre-fusion structure of a human coronavirus spike protein The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles keywords: coronavirus; cov-2; covid-19; covs; disease; health; host; human; infection; novel; patients; protein; receptor; sars; syndrome cache: cord-344217-kci4uw7u.txt plain text: cord-344217-kci4uw7u.txt item: #454 of 515 id: cord-344246-sf9cymhc author: Diriba, Kuma title: The effect of coronavirus infection (SARS-CoV-2, MERS-CoV, and SARS-CoV) during pregnancy and the possibility of vertical maternal–fetal transmission: a systematic review and meta-analysis date: 2020-09-04 words: 5149 flesch: 41 summary: Only published articles with fully accessible data on pregnant women infected with SARS-CoV, MARS-CoV, and SARS-CoV-2 were included. From the total coronavirus infected pregnant women, 56.9% delivered by cesarean, 31.3% admitted to ICU, while 2.7% were died. keywords: coronavirus; cov; covid-19; infection; maternal; pregnancy; sars; studies; transmission; women cache: cord-344246-sf9cymhc.txt plain text: cord-344246-sf9cymhc.txt item: #455 of 515 id: cord-344330-zsx7wfyj author: Su, Shuo title: Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses date: 2016-03-21 words: 4548 flesch: 43 summary: Genetic drift of human coronavirus OC43 spike gene during adaptive evolution Moderate mutation rate in the SARS coronavirus genome and its implications Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus Coronavirus diversity, phylogeny and interspecies jumping Infectious diseases emerging from Chinese wet-markets: zoonotic origins of severe respiratory viral infections Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1 Recombination between nonsegmented RNA genomes of murine coronaviruses Evidence of recombinant strains of porcine epidemic diarrhea virus, United States Emergence of pathogenic coronaviruses in cats by homologous recombination between feline and canine coronaviruses Recombinant canine coronaviruses related to transmissible gastroenteritis virus of Swine are circulating in dogs Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination Genotype shift in human coronavirus OC43 and emergence of a novel genotype by natural recombination Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia Evidence from the evolutionary analysis of nucleotide sequences for a recombinant history of SARS-CoV Testing the hypothesis of a recombinant origin of the SARS-associated coronavirus Origin and possible genetic recombination of the Middle East respiratory syndrome coronavirus from the first imported case in China: phylogenetics and coalescence analysis Coronavirus 229E-related pneumonia in immunocompromised patients Coronaviruses in children Epidemiological and clinical features of human coronavirus infections among different subsets of patients Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism Severe Acute Respiratory Syndrome (SARS) Multiple organ infection and the pathogenesis of SARS A cluster of cases of severe acute respiratory syndrome in Hong Kong Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium Human coronavirus NL63 infection in Canada Croup is associated with the novel coronavirus NL63 Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong Eight-year study with 229 E and OC 43 Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong A new virus isolated from the human respiratory tract Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease Signs and symptoms in common colds Human coronavirus NL63, a new respiratory virus A previously undescribed coronavirus associated with respiratory disease in humans Evidence of a novel human coronavirus that is associated with respiratory tract disease in infants and young children Understanding human coronavirus HCoV-NL63 Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia More and more coronaviruses: human coronavirus HKU1 Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia Coronavirus HKU1 and other coronavirus infections in Hong Kong Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method Coronavirus HKU1 infection in the United States Evidence of human coronavirus HKU1 and human bocavirus in Australian children Detection of the new human coronavirus HKU1: a report of 6 cases Coronavirus HKU1 in children, Brazil Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Middle East respiratory syndrome Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection MERS in South Korea and China: a potential outbreak threat? Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Identification of a novel coronavirus in bats Coronaviruses post-SARS: update on replication and pathogenesis Antibodies to SARS coronavirus in civets Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronaviruslike virus in palm civets at an animal market and on farms Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events Isolation and characterization of a bat SARSlike coronavirus that uses the ACE2 receptor ORF8-related genetic evidence for Chinese horseshoe bats as the source of human severe acute respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease MERS coronavirus in dromedary camel herd, Saudi Arabia Isolation of MERS coronavirus from a dromedary camel MERS coronaviruses in dromedary camels Concerns about misinterpretation of recent scientific data implicating dromedary camels in epidemiology of Middle East respiratory syndrome (MERS) Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Mosaic structure of human coronavirus NL63, one thousand years of evolution Does IBV change slowly despite the capacity of the spike protein to vary greatly? keywords: coronavirus; cov; covs; hku1; human; mers; nl63; recombination; sars; syndrome cache: cord-344330-zsx7wfyj.txt plain text: cord-344330-zsx7wfyj.txt item: #456 of 515 id: cord-344954-gpb25fga author: Hashem, Anwar M title: A Highly Immunogenic, Protective, and Safe Adenovirus-Based Vaccine Expressing Middle East Respiratory Syndrome Coronavirus S1-CD40L Fusion Protein in a Transgenic Human Dipeptidyl Peptidase 4 Mouse Model date: 2019-11-15 words: 5176 flesch: 37 summary: The fusion gene was then used to generate the proposed rAd5 construct (rAd5-S1/F/CD40L) in addition to rAd5 vaccines expressing secreted and consensus S1 protein alone (rAd5-S1) and a vector control expressing Green Fluorescent Protein (rAd5-GFP) as shown in Figure 1 . Vero E6 and Huh7.5 cells were cultured and maintained in complete Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% heat-inactivated fetal bovine serum. Schematic representation of Middle East respiratory syndrome coronavirus vaccine candidates. keywords: cd40l; coronavirus; cov; mers; mice; protein; rad5; syndrome; vaccine; virus cache: cord-344954-gpb25fga.txt plain text: cord-344954-gpb25fga.txt item: #457 of 515 id: cord-345046-str19r9a author: Al Ghamdi, Mohammed title: Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia date: 2016-04-21 words: 3441 flesch: 44 summary: Hospital outbreak of Middle East respiratory syndrome coronavirus State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Jordan MERS-CoV Investigation Team. The severe acute respiratory syndrome Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Patient with new strain of coronavirus is treated in intensive care at London hospital Latest outbreak news from ProMED-mail: novel coronavirus -Middle East Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group WHO summary Family cluster of Middle East respiratory syndrome coronavirus infections KSA MERS-CoV Investigation Team. keywords: coronavirus; cov; east; interferon; mers; middle; patients; syndrome cache: cord-345046-str19r9a.txt plain text: cord-345046-str19r9a.txt item: #458 of 515 id: cord-345081-15s2i6f0 author: Al-Sehaibany, Fares S. title: Middle East respiratory syndrome in children: Dental considerations date: 2017-04-17 words: 2655 flesch: 36 summary: Update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update-as of Middle East respiratory syndrome (MERS): a new zoonotic viral pneumonia State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans MERS-CoV outbreak in Jeddah--a link to health care facilities A scenario-based evaluation of the Middle East respiratory syndrome coronavirus and the Hajj Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus infections in health care workers Middle East respiratory syndrome Middle East respiratory syndrome coronavirus in children Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises Aerosols and splatter in dentistry: a brief review of the literature and infection control implications Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study A family cluster of Middle East respiratory syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Effects of Coronavirus infections in children Cultivation of bacteria and fungi Occupational Health problems in modern dentistry: a review Blood contamination of the aerosols produced by in vivo use of ultrasonic scalers Aerosol and splatter contamination from the operative site during ultrasonic scaling Characteristics of blood-containing aerosols generated by common powered dental instruments Measurement of airborne bacteria and endotoxin generated during dental cleaning Efficacy of three face masks in preventing inhalation of airborne contaminants in dental practice Infected health care workers and patient safety: a double standard Risk assessment of dental unit waterline contamination A survey of methods used to detect nosocomial legionellosis among participants in the National Nosocomial Infections Surveillance System Legionella contamination of dental-unit water Emerging and changing viral diseases in the new millennium Middle East respiratory syndrome coronavirus MERS-CoV: current knowledge gaps In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus (MERS-CoV). keywords: coronavirus; cov; east; infection; mers; middle; syndrome cache: cord-345081-15s2i6f0.txt plain text: cord-345081-15s2i6f0.txt item: #459 of 515 id: cord-345591-zwh1xj5u author: Al-Dorzi, Hasan M. title: The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study date: 2016-10-24 words: 5885 flesch: 46 summary: The hospital mortality of ICU MERS patients was 63.4 % (0 % for the HCWs). According to the IDEP, one unit (Unit A) was designated as the primary receiving unit for MERS patients, because of its geographic location being away from main hospital traffic and because 7 of its 8 rooms were negative-pressure airborne infection isolation rooms (AIIR). keywords: care; cases; cov; hospital; icu; infection; mers; outbreak; patients; staff; syndrome; unit cache: cord-345591-zwh1xj5u.txt plain text: cord-345591-zwh1xj5u.txt item: #460 of 515 id: cord-345827-yo3uq03v author: Antiochia, Riccarda title: Developments in biosensors for CoV detection and future trends date: 2020-10-28 words: 5970 flesch: 39 summary: More importantly, SPR based biosensors show very high sensitivities, comparable to ELISA immunoassay (Gomara et al., 2000) . They do not serve for an early diagnosis and can be used as a complement to the virus detection tests for patients presenting late, after symptoms onset, to healthcare facilities or when virus detection tests are negative despite strong indications of infection. keywords: antibodies; antibody; antigen; biosensors; cov; cov-2; covid-19; detection; et al; protein; sars; surface; virus cache: cord-345827-yo3uq03v.txt plain text: cord-345827-yo3uq03v.txt item: #461 of 515 id: cord-346320-ysgz6adr author: Arabi, Yaseen M. title: Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia date: 2016-09-17 words: 4249 flesch: 42 summary: We screened potential convalescent plasma donors from 3 cohorts: 1) patients with acute respiratory illness who were suspected of having MERS-CoV or who were confirmed MERS-CoV-positive by real-time reverse transcription PCR (rRT-PCR) of upper or lower respiratory secretions; 2) healthcare workers exposed to a laboratoryconfirmed MERS-CoV patient, as identified by ongoing active surveillance of the hospital Infection Prevention and Control Department; and 3) household contacts of patients with laboratory-confirmed MERS-CoV infection. Alternative strategies to identify convalescent plasma donors with adequate antibody titers should be explored, including the sampling of serum from patients with more severe disease and sampling at earlier points during illness. keywords: antibodies; antibody; convalescent; cov; elisa; infection; mers; patients; plasma; respiratory cache: cord-346320-ysgz6adr.txt plain text: cord-346320-ysgz6adr.txt item: #462 of 515 id: cord-346331-d0s028wl author: Lackey, Kimberly A. title: SARS‐CoV‐2 and human milk: What is the evidence? date: 2020-05-30 words: 5642 flesch: 42 summary: Importantly, none of the studies on coronaviruses and human milk report validation of their collection and analytical methods for use in human milk. key: cord-346331-d0s028wl authors: Lackey, Kimberly A.; Pace, Ryan M.; Williams, Janet E.; Bode, Lars; Donovan, Sharon M.; Järvinen, Kirsi M.; Seppo, Antti E.; Raiten, Daniel J.; Meehan, Courtney L.; McGuire, Mark A.; McGuire, Michelle K. title: SARS‐CoV‐2 and human milk: What is the evidence? date: 2020-05-30 journal: keywords: breastfeeding; cov-2; et al; human; infant; infection; milk; sars; transmission; women cache: cord-346331-d0s028wl.txt plain text: cord-346331-d0s028wl.txt item: #463 of 515 id: cord-346389-gbmnoo84 author: Callender, Lauren A. title: The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19 date: 2020-08-11 words: 10050 flesch: 29 summary: Engineering Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Gilead Announces Results From Phase 3 Trial of Remdesivir in Patients With Moderate COVID-19 Available online at Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus Survival after mesenchymal stromal cell therapy in steroidrefractory acute graft-versus-host disease: systematic review and metaanalysis Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia Extraordinary GUrich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Effective treatment of severe COVID-19 patients with tocilizumab Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report Rapid and severe Covid-19 pneumonia with severe acute chest syndrome in a sickle cell patient successfully treated with tocilizumab Dissection of the effects of jak and btk inhibitors on the functionality of healthy and malignant lymphocytes COVID-19: combining antiviral and anti-inflammatory treatments Baricitinib for COVID-19: a suitable treatment? TH17 responses in cytokine storm of COVID-19: an emerging target of JAK2 inhibitor fedratinib Baricitinib restrains the immune dysregulation in COVID-19 patients. Given that comorbidities are associated with high mortality among COVID-19 patients, a better understanding of the biological mechanisms that underpin this risk are needed to enable development of appropriate preventative and therapeutic strategies. keywords: cases; cells; china; comorbidities; coronavirus; cov-2; covid-19; covid-19 patients; disease; immune; individuals; infection; patients; risk; sars; study; treatment; use cache: cord-346389-gbmnoo84.txt plain text: cord-346389-gbmnoo84.txt item: #464 of 515 id: cord-346502-x2b0ao3q author: Arabi, Yaseen M title: Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study date: 2019-06-25 words: 4095 flesch: 41 summary: Crude 90-day mortality was higher in patients who received RBV/rIFN therapy compared to those who did not Analyses of RBV therapy vs no RBV and rIFN vs no rIFN were consistent with results to the primary analysis, with no significant association with 90-day mortality or MERS-CoV RNA clearance using marginal structural modeling (Table 4 ). The objective of this study was to examine the effect of RBV/ rIFN therapy in a large cohort of critically ill patients with MERS on the 90-day mortality and MERS-CoV RNA clearance by accounting for baseline and time-varying confounders. keywords: cov; day; mers; mortality; patients; rbv; rifn; therapy; time cache: cord-346502-x2b0ao3q.txt plain text: cord-346502-x2b0ao3q.txt item: #465 of 515 id: cord-346777-zmmnn9b2 author: Lester, Sandra title: Middle East respiratory coronavirus (MERS-CoV) spike (S) protein vesicular stomatitis virus pseudoparticle neutralization assays offer a reliable alternative to the conventional neutralization assay in human seroepidemiological studies date: 2019-09-11 words: 5378 flesch: 38 summary: The amino acids 736-761 of the MERS-CoV spike protein induce neutralizing antibodies: implications for the development of vaccines and antiviral agents Serological assays for emerging coronaviruses: challenges and pitfalls Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines Retroviral vectors pseudotyped with severe acute respiratory syndrome coronavirus S protein Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses Host cell entry of middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Novel functional hepatitis C virus glycoprotein isolates identified using an optimized viral pseudotype entry assay ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice Multiplex evaluation of influenza neutralizing antibodies with potential applicability to in-field serological studies Pseudotyped lentiviral vectors: one vector, many guises Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Lack of MERS coronavirus neutralizing antibodies in humans, eastern Province, Saudi Arabia Evaluation of candidate vaccine approaches for MERS-CoV Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Receptor variation and susceptibility to middle East respiratory syndrome coronavirus infection Proteolytic processing of middle East respiratory syndrome coronavirus spikes expands virus tropism Adaptive evolution of MERS-CoV to species variation in DPP4 Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein Development of a neutralization assay for Nipah virus using pseudotype particles The production and development of H7 influenza virus pseudotypes for the study of humoral responses against avian viruses Comparative serological assays for the study of H5 and H7 avian influenza viruses Safe pseudovirusbased assay for neutralization antibodies against influenza A(H7N9) virus Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus Evaluation of a novel vesicular stomatitis virus pseudotype-based assay for detection of neutralizing antibody responses to SARS-CoV Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus Reverse genetics with a full-length infectious cDNA of the middle East respiratory syndrome coronavirus Transgene expression in the genome of middle East respiratory syndrome coronavirus based on a novel reverse genetics system utilizing red-mediated recombination cloning Cross-Reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests The authors wish to acknowledge financial support from CDC LASSI 2016. Efficient packaging of MERS-CoV S on the surface of the VSV pseudoparticles and the ability of the pseudoparticles to enter target cells through receptor binding were confirmed by comparing the titrated inoculation of Vero and BHK-21 cells of negative control VSV pseudoparticles containing no viral glycoproteins on their surface (VSV-EV) with that for VSV pseudotyped with MERS-CoV-S proteins, designated VSV-MERS-S (Fig. keywords: antibodies; assay; coronavirus; cov; human; mers; neutralization; protein; pseudoparticles; serum; vsv cache: cord-346777-zmmnn9b2.txt plain text: cord-346777-zmmnn9b2.txt item: #466 of 515 id: cord-346787-uo8k6qic author: Jorgensen, Sarah CJ title: Remdesivir: Review of pharmacology, pre‐clinical data and emerging clinical experience for COVID‐19 date: 2020-05-23 words: 5492 flesch: 46 summary: There are no exclusion criteria related to drug-drug interactions in current remdesivir clinical studies (Table 3) . These reactions tend to be idiosyncratic and uncommon whereas transaminase elevations are consistently observed in a minority of remdesivir treated patients. keywords: clinical; cov-2; covid-19; data; days; disease; drug; patients; remdesivir; sars; studies; study cache: cord-346787-uo8k6qic.txt plain text: cord-346787-uo8k6qic.txt item: #467 of 515 id: cord-347128-6lyoz8nn author: Kim, Cheorl-Ho title: SARS-CoV-2 Evolutionary Adaptation toward Host Entry and Recognition of Receptor O-Acetyl Sialylation in Virus–Host Interaction date: 2020-06-26 words: 15614 flesch: 50 summary: CoV 3CLpro (PDB: 6WX4) and the PLpro cleave the polyproteins to assemble virus proteins. The CTD of S1 recognizes protein receptors via RBDs. keywords: ace2; acetyl; acid; attachment; binding; cells; clq; coronavirus; cov; cov-2; covs; entry; glycoprotein; host; human; infection; influenza; membrane; mers; protein; receptor; sars; sas; tmprss2; viral; virus; viruses cache: cord-347128-6lyoz8nn.txt plain text: cord-347128-6lyoz8nn.txt item: #468 of 515 id: cord-347374-mryazbnq author: Okba, Nisreen M.A. title: Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease Patients date: 2020-07-17 words: 3582 flesch: 42 summary: For each dilution step (in duplicate), we diluted patient serum samples in 200 µL of OptiPro serum-free medium (https://www. thermofisher.com) and mixed 1:1 with 200 µL of virus solution containing 100 PFUs. Using serum samples from patients with PCR-confirmed SARS-CoV-2 infections, other coronaviruses, or other respiratory pathogenic infections, we validated and tested various antigens in different in-house and commercial ELISAs. keywords: antibodies; cov; cov-2; patients; samples; sars; serum cache: cord-347374-mryazbnq.txt plain text: cord-347374-mryazbnq.txt item: #469 of 515 id: cord-347460-9vechh4x author: Chang, Feng-Yee title: Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19) date: 2020-06-04 words: 8058 flesch: 38 summary: Effect of interferon alpha and cyclosporine treatment separately and in combination on Middle East respiratory syndrome coronavirus (MERS-CoV) replication in a human in-vitro and ex-vivo culture model Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Convalescent plasma as a potential therapy for COVID-19 Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling Middle East respiratory syndrome coronavirusencoded ORF8b strongly antagonizes IFN-beta promoter activation: its implication for vaccine design Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies Lianhuaqingwen exerts anti-viral and antiinflammatory activity against novel coronavirus (SARS-CoV-2) It is interesting to note that higher levels of IL-1, IL-12, IFN-gamma, IL-8, and CXCL9, in addition to the cytokines and chemokines mentioned above, were also observed in SARS patients with severe diseases. keywords: antibodies; cells; coronavirus; cov; cov-2; covid-19; cytokine; disease; human; infection; mers; patients; protein; sars; syndrome; treatment; vaccine cache: cord-347460-9vechh4x.txt plain text: cord-347460-9vechh4x.txt item: #470 of 515 id: cord-347587-auook38y author: Zhao, Guangyu title: A Novel Nanobody Targeting Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Receptor-Binding Domain Has Potent Cross-Neutralizing Activity and Protective Efficacy against MERS-CoV date: 2018-08-29 words: 6620 flesch: 49 summary: The binding between Nbs and MERS-CoV S1 or RBD protein was detected using a BiacoreS200 instrument (GE Healthcare) as previously described (29) . MERS-CoV S1 or RBD protein, as well as the RBDs with or without D539A mutation to hDPP4 receptor, a two-tailed Student t test was used. keywords: anti; binding; cov; cov rbd; fig; human; mers; nbms10; nbs; protein; rbd; receptor cache: cord-347587-auook38y.txt plain text: cord-347587-auook38y.txt item: #471 of 515 id: cord-347889-lpd1olqq author: Weston, Stuart title: A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication date: 2019-05-29 words: 8175 flesch: 48 summary: Of most interest were the large colonies, as these were thought to have been formed by yeast cells that contain deletions of genes that confer a suppressor phenotype on ORF4a-mediated slow growth. To further validate identification of YDL042C as a specific suppressor of ORF4a, ΔYDL042C yeast cells were also transformed with an empty vector or a vector expressing SARS-CoV ORF3b with a GFP tag (which does not cause a slow-growth phenotype). keywords: cells; cov; expression; fig; growth; mammalian; mers; orf4a; proteins; replication; sir2; sirt1; suppressor; yeast cache: cord-347889-lpd1olqq.txt plain text: cord-347889-lpd1olqq.txt item: #472 of 515 id: cord-348278-is20odaq author: Al-Tawfiq, Jaffar A. title: Drivers of MERS-CoV transmission: what do we know? date: 2016-02-29 words: 4629 flesch: 44 summary: An interesting study of one of the largest outbreak in Jeddah Middle eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of middle east respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study •• First study describing the clinical features of MERS cases Clinical aspects and outcomes of 70 patients with middle east respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Middle east respiratory syndrome-coronavirus (MERS-CoV): a case-control study of hospitalized patients case control study of hospitalized patients with Severe Acute Respiratory Illness (SARI) Molecular epidemiology of hospital outbreak of middle east respiratory syndrome Characteristics and outcomes of middle east respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical course and outcomes of critically ill patients with middle east respiratory syndrome coronavirus infection Outcome of critical MERS cases admitted to the intensive care unit Hospital outbreak of middle east respiratory syndrome coronavirus • First description of Hospital Outbreak of MERS cases Ribavirin and interferon alfa-2a for severe middle east respiratory syndrome coronavirus infection: a retrospective cohort study IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat middle east respiratory syndrome coronavirus pneumonia: a retrospective study Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Real-time characterization of risks of death associated with the middle east respiratory syndrome (MERS) in the Republic of Korea Middle east respiratory syndrome coronavirus disease in children Middle east respiratory syndrome coronavirus not detected in children hospitalized with acute respiratory illness in Middle east respiratory syndrome coronavirus outbreak in the Republic of Korea Respiratory tract samples, viral load, and genome fraction yield in patients with middle east respiratory syndrome Viral shedding and antibody response in 37 patients with MERS-coronavirus infection Contact investigation of a case of human novel coronavirus infection treated in a German hospital Presence of middle east respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Transmission of MERS-coronavirus in household contacts Occupational exposure to dromedaries and risk for MERS-CoV infection Comparison of serological assays in human middle east respiratory syndrome (MERS)-coronavirus infection Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralization assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology of middle east respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Lack of middle east respiratory syndrome coronavirus transmission from infected camels Managing MERS-CoV in the healthcare setting Middle east respiratory syndrome coronavirus in healthcare settings One of the reasons for the delayed diagnosis of MERS cases is the wide clinical spectrum of MERS, which ranges from asymptomatic to mild upper respiratory tract symptoms to acute fulminant pneumonia associated with multisystem failure and death keywords: care; cases; coronavirus; cov; east; mers; middle; outbreak; syndrome; transmission cache: cord-348278-is20odaq.txt plain text: cord-348278-is20odaq.txt item: #473 of 515 id: cord-348401-x2q9vyf2 author: Millet, Jean K. title: Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin date: 2016-07-15 words: 4592 flesch: 49 summary: Acute myocarditis associated with novel middle east respiratory syndrome coronavirus Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites Mechanisms of coronavirus cell entry mediated by the viral spike protein Crystal structure of the receptor-binding domain from newly emerged middle east respiratory syndrome coronavirus Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Griffithsin has antiviral activity against hepatitis C virus Host cell entry of middle east respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Isolation and characterization of Griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity Growth of human hepatoma cells lines with differentiated functions in chemically defined medium Griffithsin protects mice from genital herpes by preventing cell-to-cell spread Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein Griffithsin against emerging viruses of the family Coronaviridae Characterization of functional hepatitis C virus envelope glycoproteins The carbohydratebinding plant lectins and the non-peptidic antibiotic pradimicin A target the glycans of the coronavirus envelope glycoproteins Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding This work was supported by the French National Agency for Research (ANR, ANR-14-CE15-0008) (KS, JD, and SB). In condition c, griffithsin was added cells (DAPI nuclei stain) and S-positive cells (infected cells). keywords: cells; cov; griffithsin; infection; mers; protein; spike; virus cache: cord-348401-x2q9vyf2.txt plain text: cord-348401-x2q9vyf2.txt item: #474 of 515 id: cord-348467-a2e3f161 author: Alqahtani, Amani Salem title: Camel exposure and knowledge about MERS-CoV among Australian Hajj pilgrims in 2014 date: 2016-01-18 words: 1568 flesch: 51 summary: In conclusion, many Australian Hajj pilgrims are not aware of MERS-CoV in Saudi Arabia, and some of them engage in activities that may put them at risk of MERS-CoV; therefore, there is a need for improved awareness among Hajj pilgrims and other travelers to the Middle East regarding MERS-CoV. Infection Prevention and Control Guidelines for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Vector Borne Zoonotic Dis MERS, influenza and respiratory illness in travellers returning from the Hajj In this study, 62% of departing pilgrims were aware of the risk of contracting the disease from drinking raw camel milk while 21% were willing to drink camel milk if offered at Hajj. keywords: cov; hajj; mers; pilgrims cache: cord-348467-a2e3f161.txt plain text: cord-348467-a2e3f161.txt item: #475 of 515 id: cord-348821-2u6ki9dv author: Xu, Ping title: Clinical Characteristics of Two Human to Human Transmitted Coronaviruses: Corona Virus Disease 2019 versus Middle East Respiratory Syndrome Coronavirus. date: 2020-03-10 words: 3334 flesch: 43 summary: The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health -the latest 2019 novel coronavirus outbreak in Wuhan, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Clinical and Laboratory Findings of Middle East Respiratory Syndrome Coronavirus Infection Characteristics and outcome of viral pneumonia caused by influenza and Middle East respiratory syndrome-coronavirus infections: A 4-year experience from a tertiary care center Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Emerging Coronavirus 2019-nCoV Pneumonia Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: A cohort study Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study Epidemiological status of the Middle East respiratory syndrome coronavirus in 2019: an update from Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study Mortality rate of ICU patients with the Middle East Respiratory Syndrome -Coronavirus infection at King Fahad Hospital, Jeddah, Saudi Arabia Critically ill healthcare workers with the middle east respiratory syndrome (MERS): A multicenter study Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Clinical and Epidemiologic Characteristics of Spreaders of Middle East Respiratory Syndrome Coronavirus during the 2015 Outbreak in Korea Neurological Complications during Treatment of Middle East Respiratory Syndrome A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea MERS-CoV outbreak in Jeddah--a link to health care facilities Renal Complications and Their Prognosis in Korean Patients with Middle East Respiratory Syndrome-Coronavirus from the Central MERS-CoV Designated Hospital Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Estimating the mean and variance from the median, range, and the size of a sample The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. key: cord-348821-2u6ki9dv authors: Xu, Ping; Sun, Guo-Dong; Li, Zhi-Zhong title: Clinical Characteristics of Two Human to Human Transmitted Coronaviruses: Corona Virus Disease 2019 versus Middle East Respiratory Syndrome Coronavirus. keywords: coronavirus; cov; covid-19; license; medrxiv; mers; preprint cache: cord-348821-2u6ki9dv.txt plain text: cord-348821-2u6ki9dv.txt item: #476 of 515 id: cord-349010-n4s8dzgp author: Al-Tawfiq, Jaffar A. title: Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) date: 2016-12-24 words: 4276 flesch: 44 summary: A review of MERS-CoV in healthcare setting Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in healthcare settings Middle East respiratory syndrome coronavirus (MERS-CoV) n d Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Oxford centre for evidence-based medicine -levels of evidence Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays • A study of the inhibitors of MERS-CoV Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection Treatment with lopinavir/ ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset • A primate model of MERS-CoV infection Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Middle East respiratory syndrome coronavirus (MERS-CoV) infection mediated by the transmembrane serine protease TMPRSS2 Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Cyclosporin A inhibits the replication of diverse coronaviruses Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) Mycophenolic acid augments interferon-stimulated gene expression and inhibits hepatitis C virus infection in vitro and in vivo Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Passive transfer of A Germline-like neutralizing human monoclonal antibody protects transgenic mice against lethal Middle East respiratory syndrome coronavirus infection Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection Treatment with interferon-alpha 2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study The first study of interferon and ribavirin in MERS-CoV Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study •• A large cohort study of ribavirin-interferon in MERS-CoV patients Acute management and longterm survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Combination therapy with lopinavir/ ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Middle East respiratory syndrome coronavirus during pregnancy Middle Eastern Respiratory Syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Guidelines for the laboratory diagnosis of Middle East respiratory syndrome coronavirus in Korea Inhibition of Middle East respiratory syndrome coronavirus (MERS-CoV) infection by anti-CD26 monoclonal antibody Pre-and postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV The multifunctional or moonlighting protein CD26/DPPIV Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A Successful treatment of avianorigin influenza A (H7N9) infection using convalescent plasma Successful treatment of avian influenza with convalescent plasma The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) into the United States Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol Antibody response and disease severity in healthcare worker MERS survivors Transmission of MERScoronavirus in household contacts Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection •• A study of viral shedding of MERS-CoV Kinetics of serologic responses to mers coronavirus infection in humans Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Clinical recommendations from an observational study on MERS: keywords: antibodies; coronavirus; cov; east; infection; interferon; mers; middle; patients; syndrome cache: cord-349010-n4s8dzgp.txt plain text: cord-349010-n4s8dzgp.txt item: #477 of 515 id: cord-349262-gnqbyc6t author: Hemida, Maged Gomaa title: The Middle East respiratory syndrome coronavirus in the breath of some infected dromedary camels (Camelus dromedarius) date: 2020-10-14 words: 3174 flesch: 58 summary: Middle East respiratory syndrome coronavirus (MERS-CoV) neutralising antibodies in a high-risk human population Comparative serological study for the prevalence of anti-MERS coronavirus antibodies in high-and low-risk groups in Qatar Middle East respiratory syndrome coronavirus during pregnancy Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Longitudinal study of Middle East respiratory syndrome coronavirus infection in dromedary camel herds in Saudi Arabia MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Africa and Middle East Genetic evidence of Middle East respiratory syndrome coronavirus (MERS-Cov) and widespread seroprevalence among camels in Kenya Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate MERS-CoV at the animal-human interface: inputs on exposure pathways from an expert-opinion elicitation Middle East respiratory syndrome coronavirus and the one health concept Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) The viral RNAs were extracted from paired swabs and breath samples collected from dromedary camels using the Qiagen viral RNA (RNeasy Mini Kit, Qiagen, Hilden, Germany) extraction kit, according to the manufacturer's protocol. keywords: animals; breath; camels; cov; dromedary; mers; nasal; virus cache: cord-349262-gnqbyc6t.txt plain text: cord-349262-gnqbyc6t.txt item: #478 of 515 id: cord-349287-mwj2qby4 author: Mackay, Ian M. title: MERS coronavirus: diagnostics, epidemiology and transmission date: 2015-12-22 words: 14293 flesch: 47 summary: There are human MERS cases that do not fall into either category of source and it is unclear if these acquired infection through some entirely separate route, or from cases that escaped diagnosis. However, on occasion, even LRT specimens from MERS cases may initially be negative, only to later become positive by RT-PCR [95] . keywords: camels; cases; contact; coronavirus; cov; dcs; disease; east; hospital; human; infected; infection; ksa; mers; middle; middle east; outbreak; respiratory; rna; south; syndrome; syndrome coronavirus; transmission cache: cord-349287-mwj2qby4.txt plain text: cord-349287-mwj2qby4.txt item: #479 of 515 id: cord-349300-x50tvq3a author: de Wit, Emmie title: Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection date: 2020-03-24 words: 4540 flesch: 36 summary: Absence of histologic lung lesions, as seen in two out of the six animals with therapeutic remdesivir treatment, has so far rarely been observed in studies testing the efficacy of MERS-CoV antivirals in nonhuman primate models (13) (14) (15) (16) ; it has only been shown once before in one out of three common marmosets treated with hyperimmune plasma at 6 h after inoculation (17) . Therapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit, with a reduction in clinical signs, reduced virus replication in the lungs, and decreased presence and severity of lung lesions. keywords: animals; cov; group; lung; mers; remdesivir; rhesus; treatment; vehicle cache: cord-349300-x50tvq3a.txt plain text: cord-349300-x50tvq3a.txt item: #480 of 515 id: cord-349643-jtx7ni9b author: Uyeki, Timothy M. title: Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus date: 2016-07-17 words: 4808 flesch: 14 summary: Interferon alfa-n3 for the treatment of Middle East respiratory syndrome Systematic review of treatment effects Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 Evaluation of SSYA10-001 as a replication inhibitor of SARS, MHV and MERS coronaviruses Anti-infective immunoadhesins from plants Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Anti-MERS-COV convalescent plasma therapy Cows with human chromosomes enlisted to fight hantavirus Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution A conformationdependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in MERS-CoV spike protein Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Coronaviruses-drug discovery and therapeutic options 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Evaluation of candidate vaccine approaches for MERS-CoV A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates Phase I, open label dose ranging safety study of GLS-5300 in healthy volunteers Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant modified vaccinia virus Ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus Evaluation of serologic and antigenic relationships between Middle Eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Camels emit dangerous MERS virus, CSU confirms MERS surges again, but pandemic jitters ease Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice MERS-CoV in upper respiratory tract and lungs of dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Time course of MERS-CoV infection and immunity in dromedary camels High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in United Arab Emirates Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways International Severe Acute Respiratory and Emerging Infection Consortium. In addition, the risk for antibody-dependent enhancement of disease may interrupt the timeline for conducting human clinical trials of MERS CoV vaccines and immunotherapeutics. keywords: coronavirus; countermeasures; cov; development; east; human; infection; mers; middle; potential; respiratory; syndrome cache: cord-349643-jtx7ni9b.txt plain text: cord-349643-jtx7ni9b.txt item: #481 of 515 id: cord-349661-ppw80s0l author: Al Ghobain, Mohammed title: Perception and Attitude of Emergency Room Resident Physicians toward Middle East Respiratory Syndrome Outbreak date: 2017-04-10 words: 2004 flesch: 49 summary: There were also no significant differences in terms of knowledge of MERS but respondents who had previously provided care for MERS patients were more likely to agree that the job put them at risk and were more afraid of being infected ( = 0.016 and = 0.040, respectively) (data not shown in tables). Our study demonstrated the considerable psychological impact of MERS outbreaks on ERRPs. keywords: errps; impact; mers; outbreak; study cache: cord-349661-ppw80s0l.txt plain text: cord-349661-ppw80s0l.txt item: #482 of 515 id: cord-349680-rz2ep5jf author: Lee, Jacob title: Better Understanding on MERS Corona Virus Outbreak in Korea date: 2015-06-10 words: 854 flesch: 60 summary: By June 9, 2015, 2 medical staffs in the Clinic A and C, one medical staff in the Hospital B, one patient and her wife who was together with the index case in the same room and 35 of admitted patients in the same ward and their family members visiting same ward with the index case in the Hospital B were confirmed to have been infected with MERS-CoV. After then, several tertiary cases were identified in the Hospital B or other hospitals that secondary patients were transferred from the Hospital B. A total of 108 people were infected, and 9 (8.3%) of them died by June 10, 2015. Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation keywords: cov; mers cache: cord-349680-rz2ep5jf.txt plain text: cord-349680-rz2ep5jf.txt item: #483 of 515 id: cord-349781-l93978vq author: Cong, Yu title: MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells date: 2018-03-22 words: 5673 flesch: 47 summary: To address pharmaceutical efficacy against MERS-CoV infection in primary cells critical for blocking infection, we tested several candidate MERS-antivirals in human MDMs and immature dendritic cells. These results demonstrate the value of testing drugs in primary cells, in addition to established cell lines, before initiating preclinical or clinical studies for MERS treatment and the importance of carefully assessing cytotoxicity in drug screen assays. keywords: apcs; cells; cov; cytokines; cytotoxicity; immature; infection; mddcs; mdms; mers; virus cache: cord-349781-l93978vq.txt plain text: cord-349781-l93978vq.txt item: #484 of 515 id: cord-349812-nw1nlc1y author: Jang, Won Mo title: Social Distancing and Transmission-reducing Practices during the 2019 Coronavirus Disease and 2015 Middle East Respiratory Syndrome Coronavirus Outbreaks in Korea date: 2020-06-09 words: 3604 flesch: 36 summary: key: cord-349812-nw1nlc1y authors: Jang, Won Mo; Jang, Deok Hyun; Lee, Jin Yong title: Social Distancing and Transmission-reducing Practices during the 2019 Coronavirus Disease and 2015 Middle East Respiratory Syndrome Coronavirus Outbreaks in Korea date: 2020-06-09 journal: J Korean Med Sci DOI: 10.3346/jkms.2020.35.e220 sha: doc_id: 349812 cord_uid: nw1nlc1y BACKGROUND: The absence of effective antiviral medications and vaccines increased the focus on non-pharmaceutical preventive behaviors for mitigating against the coronavirus disease 2019 (COVID-19) pandemic. To examine the current status of non-pharmaceutical preventive behaviors practiced during the COVID-19 outbreak and factors affecting behavioral activities, we compared to the 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in Korea. keywords: behaviors; covid-19; korea; mers; participants; survey; transmission cache: cord-349812-nw1nlc1y.txt plain text: cord-349812-nw1nlc1y.txt item: #485 of 515 id: cord-349907-dwhyx97y author: Noh, Ji Yeong title: Simultaneous detection of severe acute respiratory syndrome, Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR date: 2017-02-20 words: 3287 flesch: 56 summary: By testing the new method with bat samples as well as human samples, it could be applicable to survey SARS-CoV, MERS-CoV, and potentially their related bat CoVs in bats and human samples. It could successfully detect SARS-like CoV in bat samples but showed limited detection ability for the bat CoV HKU4 strain, which is related to MERS-CoV. However, according to a recent finding of EMC-like MERS-CoV, which was detected in bats of Saudi Arabia [18] , we assume that the new method can be helpful for screening for MERS-CoV in bat samples. keywords: bat; cov; mers; pcr; sars; time cache: cord-349907-dwhyx97y.txt plain text: cord-349907-dwhyx97y.txt item: #486 of 515 id: cord-350733-0zghspb8 author: Aronson, Jeffrey K. title: The use of mechanistic reasoning in assessing coronavirus interventions date: 2020-07-15 words: 4463 flesch: 35 summary: To explore examples of the importance of mechanistic evidence to coronavirus research. RESULTS AND CONCLUSIONS: (a) Assessment of combination therapy for MERS highlights the need for systematic assessment of mechanistic evidence. keywords: coronavirus; covid-19; evidence; interventions; mechanism; mers; sars; studies; treatment cache: cord-350733-0zghspb8.txt plain text: cord-350733-0zghspb8.txt item: #487 of 515 id: cord-350925-1h6pbfwp author: da Silva, Priscilla Gomes title: Airborne spread of infectious SARS-CoV-2: moving forward using lessons from SARS-CoV and MERS-CoV date: 2020-10-08 words: 5222 flesch: 28 summary: Among the reviewed literature, only a few papers explored viral viability in air samples (Agranovski et al., 2004; Binder et al., 2020; Booth et al., 2005; Kim et al., 2016; Lednicky et al., 2020; Lednicky et al., 2020a; Pyankov et al., 2018; Santarpia et al., 2020; van Doremalen et al., 2013 van Doremalen et al., , 2020 Xiao et al., 2004) . Currently, there is still debate about whether or not SARS-CoV-2 is transmitted through aerosols produced by infected people during talking, singing sneezing, coughing and breathing, and further studies regarding this route of transmission are needed in order To explore the feasibility of a new personal bioaerosol sampler for monitoring of viable airborne SARS virus. keywords: air; cov; cov-2; et al; humidity; mers; sars; transmission; viral; virus; viruses cache: cord-350925-1h6pbfwp.txt plain text: cord-350925-1h6pbfwp.txt item: #488 of 515 id: cord-351186-llnlto7p author: Park, Yong-Shik title: The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak date: 2015-11-14 words: 2864 flesch: 40 summary: Through personal and phone interviews we contacted employees at business facility in Saudi Arabia who may have had contact with Patient #1 during the incubation period; we investigated the places he visited, presence or absence of MERS symptoms in the individuals he contacted, history of visiting medical facilities in the Middle East, and history of consuming camel milk or meat, among other things. Thereafter, a MERS crisis transpired for the first time wherein a total of 186 patients were confirmed with MERS infection; 36 deaths occurred among these patients, and 16,693 individuals were quarantined for prevention. keywords: korea; medical; mers; middle; outbreak; patient cache: cord-351186-llnlto7p.txt plain text: cord-351186-llnlto7p.txt item: #489 of 515 id: cord-351413-3nfukrfl author: Al-Ahmadi, Khalid title: Spatiotemporal Clustering of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Incidence in Saudi Arabia, 2012–2019 date: 2019-07-15 words: 4542 flesch: 43 summary: A systematic review Presence of middle east respiratory syndrome Coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study High prevalence of MERS-CoV infection in Camel workers in Saudi Arabia Risk factors for MERS-CoV seropositivity among animal market and slaughterhouse workers A more detailed picture of the epidemiology of middle east respiratory syndrome Coronavirus Camel meat in the world Peri-urban Camel (Camelus dromendarius) Production System in Saudi Arabia: A note Water, and Agriculture in Saudi Arabia Numbering and Tracking Camels Electronically Transmission of MERS-Coronavirus in household contacts Middle east respiratory syndrome Coronavirus: Risk factors and determinants of primary, household, and nosocomial transmission Hospital outbreak of middle east respiratory syndrome Coronavirus Hospital-associated middle east respiratory syndrome Coronavirus infections Identified transmission dynamics of middle east respiratory syndrome Coronavirus infection during an outbreak: Implications of an overcrowded emergency department Outbreak of middle east respiratory syndrome at tertiary care hospital Isolation of a novel Coronavirus from a man with pneumonia in Saudi Arabia Emergencies: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Evidence for camel-to-human transmission of MERS Coronavirus Community case clusters of middle east respiratory syndrome Coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: A descriptive genomic study Global status of middle east respiratory syndrome Coronavirus in dromedary camels: keywords: arabia; cases; clusters; cov; incidence; infection; mers; risk; saudi cache: cord-351413-3nfukrfl.txt plain text: cord-351413-3nfukrfl.txt item: #490 of 515 id: cord-351685-n70tkf38 author: Altamimi, Asmaa title: Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory date: 2020-02-19 words: 3460 flesch: 52 summary: Similarly, two more single-centre case control studies reported that the presenting symptoms of MERS-CoV infection were not specific [18, 19] . Physicians and public health practitioners need to identify suspected cases which have higher chances of diagnosis as confirmed cases prior to laboratory testing (which usually takes between 12 and 24 hours). Therefore, the identification of suspected cases that may have higher chances of being diagnosed as cases of MERS-CoV is essential. keywords: cases; coronavirus; cov; east; mers; middle; study; syndrome cache: cord-351685-n70tkf38.txt plain text: cord-351685-n70tkf38.txt item: #491 of 515 id: cord-351760-698voi9y author: Han, Hui-Ju title: Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus Infection date: 2018-11-30 words: 4167 flesch: 45 summary: Development of therapeutic neutralizing mAbs targeting those critically conserved residues might be important for combating MERS-CoV. Moreover, a study found a mouse-derived neutralizing mAb, 5F9, which bound to a possible linear epitope in the NTD of the MERS-CoV S1 subunit, exhibited efficient neutralizing activity against pseudovirus and live MERS-CoV in cell entry tests. There are no approved vaccines or therapies for MERS until now. keywords: binding; cov; human; infection; mabs; mers; neutralizing; rbd cache: cord-351760-698voi9y.txt plain text: cord-351760-698voi9y.txt item: #492 of 515 id: cord-351852-ilxaurgt author: Jung, Heeja title: Assessing the Presence of Post-Traumatic Stress and Turnover Intention Among Nurses Post–Middle East Respiratory Syndrome Outbreak: The Importance of Supervisor Support date: 2020-03-09 words: 3662 flesch: 49 summary: High PTSD scores were positively associated with high turnover intention, and supervisor support was proven to have a strong buffering effect. The average turnover intention of nurses in this study was 16.29 when the total score range is from 4 to 20, showing high turnover intention. keywords: intention; nurses; outbreak; ptsd; stress; support; turnover cache: cord-351852-ilxaurgt.txt plain text: cord-351852-ilxaurgt.txt item: #493 of 515 id: cord-352256-qxdakdk0 author: Yousefi, Bahman title: A global treatments for coronaviruses including COVID‐19 date: 2020-05-11 words: 4045 flesch: 31 summary: A retrospective cohort study New insights on the antiviral effects of chloroquine against coronavirus: What to expect for COVID-19? Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Effectiveness of favipiravir (T-705) against wildtype and oseltamivir-resistant influenza B virus in mice Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Mechanisms of action of ribavirin against distinct viruses Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Neuraminidase inhibitors such as oseltamivir, peramivir, and zanamivir are invalid for 2019‐nCoV and are not recommended for treatment but protease inhibitors such as lopinavir/ritonavir (LPV/r) inhibit the progression of MERS‐CoV disease and can be useful for patients of COVID‐19 and, in combination with Arbidol, has a direct antiviral effect on early replication of SARS‐CoV. Ribavirin reduces hemoglobin concentrations in respiratory patients, and remdesivir improves respiratory symptoms. keywords: ace2; coronavirus; cov; ncov; patients; receptor; ribavirin; sars; treatment cache: cord-352256-qxdakdk0.txt plain text: cord-352256-qxdakdk0.txt item: #494 of 515 id: cord-352322-tsjwnvkk author: Khamassi Khbou, Médiha title: Coronaviruses in farm animals: Epidemiology and public health implications date: 2020-09-25 words: 8119 flesch: 31 summary: Molecular evolutionary genetics analysis version 7.0 for bigger datasets Coronavirus: How a large RNA viral genome is replicated and transcribed First genome sequences of buffalo coronavirus from water buffaloes in Bangladesh Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits Porcine respiratory coronavirus: Molecular features and virus-host interactions Detection and phylogenetic analysis of porcine deltacoronavirus in Korean swine farms Causative agents and epidemiology of diarrhea in Korean native calves Structure, function, and evolution of coronavirus spike proteins Full-length genome sequence of porcine deltacoronavirus strain USA/IA/2014/8734 Complete genome sequence of a novel swine acute diarrhea syndrome coronavirus Susceptibility of chickens to porcine deltacoronavirus infection Mutation in spike protein cleavage site and pathogenesis of feline coronavirus Infectious bronchitis virus variants: Molecular analysis and pathogenicity investigation Bovine coronavirus in neonatal calf diarrhoea in Iran Role of transportation in spread of porcine epidemic diarrhea virus infection. Vector-Borne and Zoonotic Diseases Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: keywords: animal; bcov; bovine; calves; coronavirus; cov; covs; diarrhea; disease; epidemic; et al; humans; infection; mers; new; pigs; porcine; prevalence; sars; species; swine; syndrome cache: cord-352322-tsjwnvkk.txt plain text: cord-352322-tsjwnvkk.txt item: #495 of 515 id: cord-352492-6ihyiwgb author: Eickmann, Markus title: Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively date: 2018-05-06 words: 3006 flesch: 45 summary: In vivo studies Storage of platelets in additive solutions: effects of phosphate Two pathogen reduction technologies-methylene blue plus light and shortwave ultraviolet light-effectively inactivate hepatitis C virus in blood products The effectiveness of UVC pathogen inactivation system on reducing the Trypansosoma cruzi and Leishmania infantum burden in platelets The efficacy of the ultraviolet C pathogen inactivation system in the reduction of Babesia divergens in pooled buffy coat platelets Challenge study of the pathogen reduction capacity of the THERAFLEX MB-Plasma technology The efficacy of photochemical treatment with methylene blue and light for the reduction of Trypanosoma cruzi in infected plasma Emerging pathogens: the epidemiology and evolution of species jumps Treatment of blood with a pathogen reduction technology using ultraviolet light and riboflavin inactivates Ebola virus in vitro Mannose-binding lectin binds to Ebola and Marburg envelope glycoproteins, resulting in blocking of virus interaction with DC-SIGN and complementmediated virus neutralization Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients Clinical recognition and management of patients exposed to biological warfare agents At 0.15 J/cm 2 (75% of the full UVC dose), EBOV and MERS-CoV infectivity levels were below the detection limit, resulting in virus reduction factors of greater than 4.5 for EBOV and of greater than 3.7 for MERS-CoV. Table 2 , light doses as low as 30 J/cm 2 , or 25% of the standard full light dose of 120 J/cm 2 for LED-based illumination, inactivated EBOV and MERS-CoV in plasma to levels below the detection limit. keywords: blood; cov; ebov; light; mers; plasma; theraflex; virus cache: cord-352492-6ihyiwgb.txt plain text: cord-352492-6ihyiwgb.txt item: #496 of 515 id: cord-352527-eeyqh9nc author: Zhou, Yusen title: Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain date: 2019-01-14 words: 5878 flesch: 37 summary: An epidemiological outbreak study Outbreak of Middle East respiratory syndrome at tertiary care hospital Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections Family cluster of Middle East respiratory syndrome coronavirus infections Healthcare-associated infections: The hallmark of Middle East respiratory syndrome coronavirus with review of the literature Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: A report of nosocomial transmission Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus Persistence of antibodies against Middle East respiratory syndrome coronavirus Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: A study protocol Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: A single centre experience Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: A phase 1 randomised, double-blind, single-dose-escalation study Prospects for a MERS-CoV spike vaccine Current advancements and potential strategies in the development of MERS-CoV vaccines Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? CoV spike protein: A key target for antivirals Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Reverse genetics with a full-length infectious cDNA of the Middle East Report of two cases & review of the literature MERS-CoV infection in a pregnant woman in Korea Middle East respiratory syndrome coronavirus in pediatrics: A report of seven cases from Saudi Arabia Middle East respiratory syndrome coronavirus infection during pregnancy: A Report of 5 cases from Saudi Arabia An outbreak of Middle East respiratory syndrome coronavirus infection in South Korea Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Discovery of novel bat coronaviruses in south China that use the same receptor as Middle East respiratory syndrome coronavirus Rapid detection of MERS coronavirus-like viruses in bats: Pote1ntial for tracking MERS coronavirus transmission and animal origin Receptor usage of a novel bat lineage C Betacoronavirus reveals evolution of Middle East respiratory syndrome-related coronavirus spike proteins for human dipeptidyl peptidase 4 binding MERS-CoV spillover at the camel-human interface Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation High prevalence of MERS-CoV infection in camel workers in Saudi Arabia The prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) antibodies in dromedary camels in Israel Serologic evidence for MERS-CoV infection in dromedary camels Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Dromedary camels in northern Mali have high seropositivity to MERS-CoV Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia county Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Middle East respiratory syndrome coronavirus: Risk factors and determinants of primary, household, and nosocomial transmission Unusual presentation of Middle East respiratory syndrome coronavirus leading to a large outbreak in Riyadh during 2017 Outbreaks of Middle East respiratory syndrome in two hospitals initiated by a single patient in Daejeon MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: keywords: binding; coronavirus; cov; dpp4; east; human; mers; middle; protein; rbd; receptor; respiratory; syndrome cache: cord-352527-eeyqh9nc.txt plain text: cord-352527-eeyqh9nc.txt item: #497 of 515 id: cord-352741-0pdeehai author: Geramizadeh, Bita title: Histopathologic Findings of Coronavirus in Lung: A Mini-Review date: 2020-10-12 words: 2161 flesch: 37 summary: Coronaviruses: an overview of their replication and pathogenesis Emerging coronaviruses: genome structure, replication, and pathogenesis Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients Pulmonary pathology of earlyphase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore. Challenges in determining a SARS diagnosis The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Lung pathology of fatal severe acute respiratory syndrome Multiple organ infection and the pathogenesis of SARS Pulmonary pathology and COVID-19: lessons from autopsy. keywords: alveolar; findings; lung; sars; syndrome cache: cord-352741-0pdeehai.txt plain text: cord-352741-0pdeehai.txt item: #498 of 515 id: cord-352899-bt2xg0ha author: Van Kerkhove, Maria D. title: Interpreting Results From Environmental Contamination Studies of Middle East Respiratory Syndrome Coronavirus date: 2016-10-15 words: 805 flesch: 33 summary: Maria D. Van Kerkhove, 1,2 Malik J. S. Peiris, 3 Mamunur Rahman Malik, 4 and Peter Ben Embarek 2 Middle East respiratory syndrome coronavirus (MERS-CoV): current situation 3 years after the virus was first identified Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Notes from the field: nosocomial outbreak of Middle East respiratory syndrome in a large tertiary care hospital-Riyadh Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS outbreak units Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Environmental contamination and viral shedding in MERS patients Middle East respiratory syndrome coronavirus (MERS-CoV) [3] , but the role of environmental contamination has received relatively little attention. keywords: contamination; cov; mers cache: cord-352899-bt2xg0ha.txt plain text: cord-352899-bt2xg0ha.txt item: #499 of 515 id: cord-353121-ot7jsx20 author: Choi, Jun Yong title: Absence of neutralizing activity in serum 1 year after successful treatment with antivirals and recovery from MERS in South Korea date: 2019-01-31 words: 1400 flesch: 50 summary: So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection. So, significant neutralizing activity was not demonstrated in any sera of three patients with mild pneumonia >1 year after being successfully treated with antiviral agents and recovering from MERS coronavirus infection. keywords: activity; cov; june; mers cache: cord-353121-ot7jsx20.txt plain text: cord-353121-ot7jsx20.txt item: #500 of 515 id: cord-353342-2n6kqyeo author: Corman, Victor M. title: Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection date: 2016-02-15 words: 4051 flesch: 50 summary: WHO/MERS/RA/15 MERS-CoV outbreak in Jeddah-a link to health care facilities An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea The aetiology, origins, and diagnosis of severe acute respiratory syndrome Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Infectious Middle East respiratory syndrome coronavirus excretion and serotype variability based on live virus isolates from patients in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Transmission of MERS-coronavirus in household contacts Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Antibodies against MERS coronavirus in dromedary camels Middle East respiratory syndrome Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Evaluation of advanced reverse transcription-PCR assays and an alternative PCR target region for detection of severe acute respiratory syndrome-associated coronavirus Detection of SARS coronavirus in patients with severe acute respiratory syndrome by conventional and real-time quantitative reverse transcription-PCR assays The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients Detection of SARS coronavirus in patients with suspected SARS Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential Detection of SARS coronavirus in plasma by real-time RT-PCR Quantitative analysis and prognostic implication of SARS coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome Detection of severe acute respiratory syndrome coronavirus RNA in plasma during the course of infection Multiple organ infection and the pathogenesis of SARS Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells SARS-coronavirus replicates in mononuclear cells of peripheral blood (PBMCs) from SARS patients SARS-coronavirus replication in human peripheral monocytes/macrophages Acute renal impairment in coronavirusassociated severe acute respiratory syndrome Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection Contact investigation of a case of human novel coronavirus infection treated in a German hospital Acknowledgments. As in SARS, kidney failure in MERS patients might well be explained by severe inflammatory reaction combined with the administration of potentially nephrotoxic drugs during intensive care keywords: cases; coronavirus; cov; mers; patients; rna; samples; sars; syndrome cache: cord-353342-2n6kqyeo.txt plain text: cord-353342-2n6kqyeo.txt item: #501 of 515 id: cord-353495-c3s5n5vo author: Yao, Yanfeng title: An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus date: 2014-01-15 words: 3434 flesch: 46 summary: Nonhuman primates have been useful for evaluating vaccines and studying disease pathogenesis for several respiratory viruses, including influenza, SARS-CoV, respiratory syncytial virus, and human parainfluenza viruses. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. keywords: coronavirus; cov; human; infection; mers; model; monkeys; virus cache: cord-353495-c3s5n5vo.txt plain text: cord-353495-c3s5n5vo.txt item: #502 of 515 id: cord-353704-lfndq85x author: Ye, Zi-Wei title: Zoonotic origins of human coronaviruses date: 2020-03-15 words: 8121 flesch: 50 summary: Sci China Life Sci Cultivation of the virus of infectious bronchitis of chickens in embryonated chicken eggs A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin Transmissible gastroenteritis in pigs Electron microscopy of coronavirus-like particles characteristic of turkey bluecomb disease Characterization of a feline infectious peritonitis virus isolate Recovery and characterization of a coronavirus from military dogs with diarrhea A new virus isolated from the human respiratory tract Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease Signs and symptoms in common colds Effects of a new human respiratory virus in volunteers From SARS coronavirus to novel animal and human coronaviruses Identification of a new human coronavirus Understanding Human Coronavirus HCoV-NL63 A previously undescribed coronavirus associated with respiratory disease in humans Croup is associated with the novel coronavirus NL63 Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Coronavirus HKU1 and other coronavirus infections in Hong Kong Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China Emergence of the Middle East respiratory syndrome coronavirus Clinical features of patients infected with 2019 novel coronavirus in Wuhan Detection of human coronaviruses in children with acute gastroenteritis Prevalence of IgG antibody to SARS-associated coronavirus in animal traders Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Identification of a novel coronavirus in bats Antibodies to SARS coronavirus in civets Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats Bats are natural reservoirs of SARS-like coronaviruses Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Full-genome deep sequencing and phylogenetic analysis of novel human betacoronavirus Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding Discovery of Novel Bat Coronaviruses in South China Diffuse alveolar damage, epithelial cell proliferation and an increase of macrophages are also observed in SARS patients [31] . keywords: animal; bats; coronavirus; cov; cov-2; covs; hcov; host; human; infection; mers; sars; transmission; viruses cache: cord-353704-lfndq85x.txt plain text: cord-353704-lfndq85x.txt item: #503 of 515 id: cord-353732-7hjsux4m author: Arabi, Yaseen M. title: Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physicians date: 2016-07-12 words: 2416 flesch: 41 summary: First Confirmed Cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in the United States, Updated Information on the Epidemiology of MERS-CoV Infection, and Guidance for the Public, Clinicians, and Public Health Authorities Use of convalescent plasma therapy in SARS patients in Hong Kong Successful treatment of avian influenza with convalescent plasma Convalescent Plasma Study Group Family cluster of Middle East respiratory syndrome coronavirus infections Not applicable. Our survey results indicate that the research infrastructure at many acute care facilities in Saudi Arabia is likely generally sufficient to conduct a RCT to investigate the efficacy of convalescent plasma treatment for severely ill patients with MERS-CoV. Next steps in such a research program will need to include an observational study of actual clinical and diagnostic practice in the care of patients with MERS-CoV in KSA. keywords: cov; infection; mers; patients; respondents; survey cache: cord-353732-7hjsux4m.txt plain text: cord-353732-7hjsux4m.txt item: #504 of 515 id: cord-353965-0bb729sp author: Halim, Ashraf Abdel title: Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients date: 2016-01-31 words: 3655 flesch: 42 summary: Patients and methods This study included 32 laboratory confirmed MERS corona virus infected patients who were admitted into ICU. This study included 32 laboratory confirmed MERS corona virus patients who were admitted into ICU. keywords: mortality; patients; smoking; survivors cache: cord-353965-0bb729sp.txt plain text: cord-353965-0bb729sp.txt item: #505 of 515 id: cord-354272-99vw735a author: DARLING, N. D. title: Retrospective, epidemiological cluster analysis of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic using open source data date: 2017-10-24 words: 3551 flesch: 45 summary: The absence of apparent seasonality in the identified clusters further supports the significant role humanto-human transmission in healthcare settings plays in the propagation of MERS-CoV. Classification of each cluster into one or more of the three disease transmission categories (nosocomial, household, or exported) elucidated common characteristics among the clusters, including the overall concentration of case clusters in cities and healthcare institutions. Of the 51 identified clusters, 41 (80·4%) were classified as nosocomial clusters; 12 (23·5%) were household clusters; and eight (15·7%) were exported (Table 3 ). keywords: cases; clusters; coronavirus; cov; date; mers; transmission cache: cord-354272-99vw735a.txt plain text: cord-354272-99vw735a.txt item: #506 of 515 id: cord-354302-l2kywzro author: Adney, Danielle R. title: Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels date: 2014-12-17 words: 3291 flesch: 43 summary: Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Dynamics of passive immunity to West Nile virus in domestic chickens (Gallus gallus domesticus) Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through wholegenome analysis and virus cultured from dromedary camels in Saudi Arabia Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). keywords: camels; coronavirus; cov; east; mers; middle; virus cache: cord-354302-l2kywzro.txt plain text: cord-354302-l2kywzro.txt item: #507 of 515 id: cord-354474-hbl2ywix author: Temsah, M. H. title: Knowledge, attitudes and practices of healthcare workers during the early COVID-19 pandemic in a main, academic tertiary care centre in Saudi Arabia date: 2020-08-28 words: 4150 flesch: 43 summary: In addition, we assessed [19] the perceived adequacy of COVID-19 information and [15] perceived high fear/stress from the COVID-19 pandemic as compared to the previous MERS-CoV outbreak. A higher perceived adequacy of COVID-19 information (mean: 3.97 ± 1.00 vs. 3.7 ± 0.92, P = 0.001) and better hygienic practices (3.10 ± 0.84 vs. 2.65 ± 0.87, P < 0.001) were observed among HCWs who attended the Educational Day conference (Fig. 2) . keywords: covid-19; hcws; knowledge; mers; pandemic; study cache: cord-354474-hbl2ywix.txt plain text: cord-354474-hbl2ywix.txt item: #508 of 515 id: cord-354536-c9v9kbw8 author: Han, Yan-Jie title: Advances and challenges in the prevention and treatment of COVID-19 date: 2020-07-09 words: 5277 flesch: 41 summary: 61, 62 Chloroquine phosphate can block virus infection by up-regulating the pH of endosomes, required low for virus-cell fusion, and inhibiting glycosylation of cellular receptors. 73 Blood-derived immunotherapy based on recovered patients can be used to treat infections including measles virus, Lhasa virus, SARS coronavirus and influenza A H5N1 virus. keywords: coronavirus; cov; cov-2; human; infection; interferon; mers; protein; replication; sars; treatment; vitro cache: cord-354536-c9v9kbw8.txt plain text: cord-354536-c9v9kbw8.txt item: #509 of 515 id: cord-354582-fniymnmf author: Ma, Zhiqian title: Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae date: 2020-06-30 words: 8398 flesch: 27 summary: In this review, we systematically describe the role of reverse genetics technology in studying the effects of coronavirus proteins on viral virulence and innate immunity, cell and tissue tropism and antiviral drug screening. Reverse genetics systems are highly valuable research tools for RNA virus vaccine development, which may be more efficient than conventional approaches with live attenuation through passing (forward genetics) or inactivation (Stobart and Moore, 2014) . keywords: acute; cdna; cells; coronavirus; cov; et al; genetics; genome; immune; mers; mhv; porcine; protein; replication; rna; sars; syndrome; type; vaccines; virulence cache: cord-354582-fniymnmf.txt plain text: cord-354582-fniymnmf.txt item: #510 of 515 id: cord-354738-4rxradwz author: Kohl, Claudia title: European Bats as Carriers of Viruses with Zoonotic Potential date: 2014-08-13 words: 4799 flesch: 45 summary: Especially the high-risk occupational groups (i.e., bat workers, bat carers in bat bat hospitals) are at increased risk. [9] [10] , while hardly anything is known about human-pathogenicity of European bat viruses apart from lyssaviruses. keywords: bat; bats; cov; european; human; lyssavirus; mers; novel; species; studies; viruses; zoonotic cache: cord-354738-4rxradwz.txt plain text: cord-354738-4rxradwz.txt item: #511 of 515 id: cord-355290-m8875kdy author: Meyer, Benjamin title: Serologic Assessment of Possibility for MERS-CoV Infection in Equids date: 2015-01-17 words: 815 flesch: 39 summary: The lower replication observed in horse cells than in VeroB4 cells may be the result of a difference in the interferon competence of the cells; replication levels in horse cells are comparable to those in bat cells (6) . It has been shown that MERS-CoV can use horse DPP-4 expressed on nonsusceptible cells (9) , but no data are available on susceptibility of primary horse cells. keywords: cells; cov; mers cache: cord-355290-m8875kdy.txt plain text: cord-355290-m8875kdy.txt item: #512 of 515 id: cord-356007-6b0w36l9 author: Alanazi, Khalid H. title: Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017 date: 2018-12-31 words: 4034 flesch: 43 summary: Furthermore, 2 physicians at clinic C tested seropositive after an indeterminate rRT-PCR test, suggesting transmission at clinic C. Thus, increased testing for MERS-CoV in an outpatient setting for individuals with known risk factors and worsening respiratory symptoms might facilitate early recognition of MERS cases. The hospital B cluster appears to have been more Age, y, median (range) 58 ( Among 38 cases linked to hospital A, 17 were patient cases, 17 were HCP cases, and 4 were family members (Table 1) . keywords: cases; cov; hcp; hospital; index; mers; patient; transmission cache: cord-356007-6b0w36l9.txt plain text: cord-356007-6b0w36l9.txt item: #513 of 515 id: cord-356192-8b96rgqa author: Xie, Qian title: Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms date: 2017-04-18 words: 2430 flesch: 48 summary: Protein sequences were aligned using MEGA (version 6.0) Even single point mutations in the transmembrane protein of the infectious bronchitis virus (IBV) E protein [23] , or amino acid changes in the N-terminus of the SARS-CoV E protein can result in attenuation of virulence [24] . keywords: coronavirus; cov; mers; middle; orf5; protein; syndrome cache: cord-356192-8b96rgqa.txt plain text: cord-356192-8b96rgqa.txt item: #514 of 515 id: cord-356219-wl9htpp2 author: Farag, Elmoubasher A. B. A. title: High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014 date: 2015-07-15 words: 1817 flesch: 49 summary: Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV) Á seventeenth update Middle East respiratory syndrome: an emerging coronavirus infection tracked by the crowd Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Isolation of MERS coronavirus from a dromedary camel Reliable typing of MERS-CoV variants with a small genome fragment Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Occupational exposure to dromedaries and risk for MERS-CoV infection MERS coronaviruses in dromedary camels Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Antibodies against MERS coronavirus in dromedary camels Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia MERS Coronavirus in Dromedary Camel Herd, Saudi Arabia Animal coronavirus vaccines: lessons for SARS Overall, a large proportion of MERS cases is suspected to be a result of zoonotic transmission (1) with growing evidence for dromedary camels (Camelus dromedarius) as a reservoir. keywords: animals; camels; coronavirus; cov; mers cache: cord-356219-wl9htpp2.txt plain text: cord-356219-wl9htpp2.txt item: #515 of 515 id: cord-356364-ipi81ce3 author: Ho, Bo-Lin title: Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main Protease date: 2015-12-14 words: 5061 flesch: 56 summary: Calorimetric titrations of the peptide substrate TQ6-pNA (0.5 mM in a 250-μl syringe) and M pro (6 μM in a 4-ml ampoule) were carried out at 25°C in 10 mM phosphate buffer (pH 7.6). However, thrombin digestion leaves two extra residues (Gly-Ser) at the N-terminus of M pro , resulting in protein with no proteolytic activity (data not shown). keywords: coronavirus; cov; cov m; dimerization; enzyme; fig; mers; pro; sars; substrate cache: cord-356364-ipi81ce3.txt plain text: cord-356364-ipi81ce3.txt