# bib

id: cord-252222-wyamc46k
author: Leung, Chi Hung Czarina
title: Middle East respiratory syndrome
date: 2014-05-13
extension: .txt
mime: text/plain
words: 1180
sentence: 70
flesch: 49
cache: cache/cord-252222-wyamc46k.txt
txt: txt/cord-252222-wyamc46k.txt
summary:
  Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Emerging human Middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Middle East respiratory syndrome: new disease, old lessons Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids Assessing the pandemic potential of MERS-CoV key: cord-252222-wyamc46k authors: Leung, Chi Hung Czarina; Gomersall, Charles David title: Middle East respiratory syndrome date: 2014-05-13 journal: Intensive Care Med DOI: 10.1007/s00134-014-3303-y sha: doc_id: 252222 cord_uid: wyamc46k nan Middle East respiratory syndrome (MERS) is due to RNA betacoronavirus (MERS-CoV) infection.


id: cord-300536-8okuomi6
author: Baloch, Zulqarnain
title: Unique Challenges to Control the Spread of COVID-19 in the Middle East
date: 2020-07-13
extension: .txt
mime: text/plain
words: 1944
sentence: 83
flesch: 41
cache: cache/cord-300536-8okuomi6.txt
txt: txt/cord-300536-8okuomi6.txt
summary:
  This could reflect the levels of preparedness and response plans implemented locally in Middle East countries. Although the case number was low cases in the early days of the outbreak, it has speeded at unprecedented pace later on and affecting all the Middle East countries (Figure 1 ).


id: cord-351186-llnlto7p
author: Park, Yong-Shik
title: The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak
date: 2015-11-14
extension: .txt
mime: text/plain
words: 2864
sentence: 92
flesch: 40
cache: cache/cord-351186-llnlto7p.txt
txt: txt/cord-351186-llnlto7p.txt
summary:
  Through personal and phone interviews we contacted employees at business facility in Saudi Arabia who may have had contact with Patient #1 during the incubation period; we investigated the places he visited, presence or absence of MERS symptoms in the individuals he contacted, history of visiting medical facilities in the Middle East, and history of consuming camel milk or meat, among other things. Thereafter, a MERS crisis transpired for the first time wherein a total of 186 patients were confirmed with MERS infection; 36 deaths occurred among these patients, and 16,693 individuals were quarantined for prevention.


id: cord-265666-27ckjl7w
author: Kang, Hee Sun
title: Working experiences of nurses during the Middle East respiratory syndrome outbreak
date: 2018-05-30
extension: .txt
mime: text/plain
words: 3134
sentence: 154
flesch: 53
cache: cache/cord-265666-27ckjl7w.txt
txt: txt/cord-265666-27ckjl7w.txt
summary:
  We made a package for MERS patients, a package for MERS. The hospitals rewarded working with MERS patients differently.


id: cord-332237-8oykgp0h
author: Omrani, Ali S
date: 2014-09-29
extension: .txt
mime: text/plain
words: 3323
sentence: 130
flesch: 44
cache: cache/cord-332237-8oykgp0h.txt
txt: txt/cord-332237-8oykgp0h.txt
title:
  Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study

summary:
  Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-11th update Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Hospital outbreak of Middle East respiratory syndrome coronavirus Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical management of severe acute respiratory infections when novel coronavirus is suspected: what to do and what not to do International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) key: cord-332237-8oykgp0h authors: Omrani, Ali S; Saad, Mustafa M; Baig, Kamran; Bahloul, Abdelkarim; Abdul-Matin, Mohammed; Alaidaroos, Amal Y; Almakhlafi, Ghaleb A; Albarrak, Mohammed M; Memish, Ziad A; Albarrak, Ali M title: Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study date: 2014-09-29 journal: Lancet Infect Dis DOI: 10.1016/s1473-3099(14)70920-x sha: doc_id: 332237 cord_uid: 8oykgp0h BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) infection is associated with high mortality and has no approved antiviral therapy.


id: cord-354302-l2kywzro
author: Adney, Danielle R.
title: Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
date: 2014-12-17
extension: .txt
mime: text/plain
words: 3291
sentence: 119
flesch: 43
cache: cache/cord-354302-l2kywzro.txt
txt: txt/cord-354302-l2kywzro.txt
summary:
  Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Dynamics of passive immunity to West Nile virus in domestic chickens (Gallus gallus domesticus) Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through wholegenome analysis and virus cultured from dromedary camels in Saudi Arabia Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV).


id: cord-345046-str19r9a
author: Al Ghamdi, Mohammed
date: 2016-04-21
extension: .txt
mime: text/plain
words: 3441
sentence: 181
flesch: 44
cache: cache/cord-345046-str19r9a.txt
txt: txt/cord-345046-str19r9a.txt
title:
  Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia

summary:
  Hospital outbreak of Middle East respiratory syndrome coronavirus State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Jordan MERS-CoV Investigation Team. The severe acute respiratory syndrome Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Patient with new strain of coronavirus is treated in intensive care at London hospital Latest outbreak news from ProMED-mail: novel coronavirus -Middle East Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group WHO summary Family cluster of Middle East respiratory syndrome coronavirus infections KSA MERS-CoV Investigation Team.


id: cord-323133-gdg50omp
author: Buzatto, G. P.
title: The pathogens profile in children with otitis media with effusion and adenoid hypertrophy
date: 2017-02-23
extension: .txt
mime: text/plain
words: 4245
sentence: 149
flesch: 36
cache: cache/cord-323133-gdg50omp.txt
txt: txt/cord-323133-gdg50omp.txt
summary:
  S. pneumoniae and M. catarrhalis were detected more often in middle ear washes from OME patients than controls. Although total virus detection was not statistically different from controls at the middle ear washes (p = 0.065), adenovirus was detected in higher proportions in adenoid samples of OME patients than controls (p = 0.019).


id: cord-293505-1t3hg4wi
author: Bernard-Stoecklin, Sibylle
date: 2019-05-14
extension: .txt
mime: text/plain
words: 4167
sentence: 156
flesch: 38
cache: cache/cord-293505-1t3hg4wi.txt
txt: txt/cord-293505-1t3hg4wi.txt
title:
  Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017

summary:
  Twenty-five percent (n = 105/422) of MERS cases who acquired infection in a hospital setting were healthcare personnel. After Cardiac Operations An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Hospital outbreak of Middle East respiratory syndrome coronavirus Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia MERS outbreak in Korea: hospital-to-hospital transmission Middle East Respiratory Syndrome Coronavirus Outbreak in the Republic of Korea Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from MERS:


id: cord-349010-n4s8dzgp
author: Al-Tawfiq, Jaffar A.
title: Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
date: 2016-12-24
extension: .txt
mime: text/plain
words: 4276
sentence: 204
flesch: 44
cache: cache/cord-349010-n4s8dzgp.txt
txt: txt/cord-349010-n4s8dzgp.txt
summary:
  A review of MERS-CoV in healthcare setting Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in healthcare settings Middle East respiratory syndrome coronavirus (MERS-CoV) n d Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Oxford centre for evidence-based medicine -levels of evidence Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays • A study of the inhibitors of MERS-CoV Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection Treatment with lopinavir/ ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset • A primate model of MERS-CoV infection Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Middle East respiratory syndrome coronavirus (MERS-CoV) infection mediated by the transmembrane serine protease TMPRSS2 Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Cyclosporin A inhibits the replication of diverse coronaviruses Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) Mycophenolic acid augments interferon-stimulated gene expression and inhibits hepatitis C virus infection in vitro and in vivo Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Passive transfer of A Germline-like neutralizing human monoclonal antibody protects transgenic mice against lethal Middle East respiratory syndrome coronavirus infection Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection Treatment with interferon-alpha 2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study The first study of interferon and ribavirin in MERS-CoV Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study •• A large cohort study of ribavirin-interferon in MERS-CoV patients Acute management and longterm survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Treatment outcomes for patients with Middle Eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Combination therapy with lopinavir/ ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Middle East respiratory syndrome coronavirus during pregnancy Middle Eastern Respiratory Syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Guidelines for the laboratory diagnosis of Middle East respiratory syndrome coronavirus in Korea Inhibition of Middle East respiratory syndrome coronavirus (MERS-CoV) infection by anti-CD26 monoclonal antibody Pre-and postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV The multifunctional or moonlighting protein CD26/DPPIV Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A Successful treatment of avianorigin influenza A (H7N9) infection using convalescent plasma Successful treatment of avian influenza with convalescent plasma The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) into the United States Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol Antibody response and disease severity in healthcare worker MERS survivors Transmission of MERScoronavirus in household contacts Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection •• A study of viral shedding of MERS-CoV Kinetics of serologic responses to mers coronavirus infection in humans Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Clinical recommendations from an observational study on MERS:


id: cord-304054-sn7rswab
author: Khan, Gulfaraz
title: Chapter 8 The Middle East Respiratory Syndrome Coronavirus: An Emerging Virus of Global Threat
date: 2020-12-31
extension: .txt
mime: text/plain
words: 4276
sentence: 138
flesch: 40
cache: cache/cord-304054-sn7rswab.txt
txt: txt/cord-304054-sn7rswab.txt
summary:
  respiratory syndrome coronavirus Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Middle East respiratory syndrome coronavirus infection during pregnancy: a report of 5 cases from Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Emerging and reemerging diseases in the World Health Organization (WHO) Eastern Mediterranean Region-progress, challenges, and WHO initiatives MERS-CoV: understanding the latest human coronavirus threat Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study SARS and MERS: recent insights into emerging coronaviruses Transmission of MERS-coronavirus in household contacts Vaccines for the prevention against the threat of MERS-CoV Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Molecular evolution of human coronavirus genomes The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Outbreak of Middle East respiratory syndrome at Tertiary Care Hospital Transmission of Middle East Respiratory syndrome coronavirus infections in healthcare settings A novel coronavirus capable of lethal human infections: an emerging picture Middle East respiratory syndrome infection control and prevention guideline for healthcare facilities Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Transmission routes of respiratory viruses among humans Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo MERS coronavirus: diagnostics, epidemiology and transmission Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Jumping species-a mechanism for coronavirus persistence and survival Dipeptidyl peptidase 4 distribution in the human respiratory tract Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015 Asymptomatic MERS-CoV infection in humans possibly linked to infected dromedaries imported from Oman to United Arab Emirates Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia Middle East respiratory syndrome coronavirus disease is rare in children: an update from Saudi Arabia Occurrence of the Middle East respiratory syndrome coronavirus (MERS-CoV) across the gulf corporation council countries: four years update Further evidence for bats as the evolutionary source of Middle East


id: cord-297062-dmiplvt2
author: Almekhlafi, Ghaleb A.
title: Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients
date: 2016-05-07
extension: .txt
mime: text/plain
words: 4410
sentence: 203
flesch: 45
cache: cache/cord-297062-dmiplvt2.txt
txt: txt/cord-297062-dmiplvt2.txt
summary:
  Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle Eastern respiratory syndrome corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Acute management and long-term survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS APACHE II: a severity of disease classification system The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Interestingly, Acinetobacter baumannii, which is an emerging fatal infection in ICU patients worldwide, was isolated from deep tracheal aspirates in one in four patients.


id: cord-303272-1w8epdht
author: Reusken, Chantal BEM
date: 2013-08-09
extension: .txt
mime: text/plain
words: 4493
sentence: 172
flesch: 49
cache: cache/cord-303272-1w8epdht.txt
txt: txt/cord-303272-1w8epdht.txt
title:
  Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study

summary:
  Cattle (n=80), sheep (n=40), goats (n=40), dromedary camels (n=155), and various other camelid species (n=34) were tested for specific serum IgG by protein microarray using the receptor-binding S1 subunits of spike proteins of MERS-CoV, severe acute respiratory syndrome coronavirus, and human coronavirus OC43. The receptor-binding domains, which contain the S1 subunit of spike proteins of MERS-CoV (residues 1-747), SARS-CoV (residues 1-676), and human coronavirus OC43 (residues 1-760) were expressed, purifi ed, and spotted on glass slides.


id: cord-306004-amv0los1
author: Widagdo, W.
title: Host Determinants of MERS-CoV Transmission and Pathogenesis
date: 2019-03-19
extension: .txt
mime: text/plain
words: 4537
sentence: 198
flesch: 42
cache: cache/cord-306004-amv0los1.txt
txt: txt/cord-306004-amv0los1.txt
summary:
  An epidemiological outbreak study Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: An in-vitro and ex-vivo study Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in United Arab Emirates Emerging human middle East respiratory syndrome coronavirus causes widespread infection and alveolar damage in human lungs Severe respiratory illness caused by a novel coronavirus Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract: Implications for the Middle East Respiratory Syndrome Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Human betacoronavirus 2c EMC/2012-related viruses in bats MERS-related betacoronavirus in Vespertilio superans bats Group C betacoronavirus in bat guano fertilizer Detection of Severe Acute Respiratory Syndrome-Like, Middle East Respiratory Syndrome-Like Bat Coronaviruses and Group H Rotavirus in Faeces of Korean Bats Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Close relative of human Middle East respiratory syndrome coronavirus in bat Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus Discovery of Novel Bat An outbreak investigation Human infection with MERS coronavirus after exposure to infected camels Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels Antibodies against MERS coronavirus in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-alpha treatment TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection An overview of their replication and pathogenesis


id: cord-322760-tsxniu3j
author: Sha, Jianping
date: 2016-09-23
extension: .txt
mime: text/plain
words: 4632
sentence: 183
flesch: 53
cache: cache/cord-322760-tsxniu3j.txt
txt: txt/cord-322760-tsxniu3j.txt
title:
  Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea

summary:
  [17] [18] [19] vs. 9 days [0-24], p = 0.041) and in sporadic MERS cases (12 days vs. 9 days [0-30], p = 0.003). These findings can be attributed to three facts: first, the majority of HCP developed asymptomatic or mild symptoms and moderate symptoms [15] ; second, HCP were confirmed as secondary cases under medical investigation, which led to earlier confirmation and good outcomes [32] ; third, epidemiological analysis showed that HCP were much younger and had fewer co-morbidities compared to total MERS cases [36] .


id: cord-343302-g9vcchrh
author: Agrawal, Anurodh Shankar
date: 2016-08-19
extension: .txt
mime: text/plain
words: 4820
sentence: 148
flesch: 39
cache: cache/cord-343302-g9vcchrh.txt
txt: txt/cord-343302-g9vcchrh.txt
title:
  Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

summary:
  The effect of m336 antibody treatment on the pulmonary pathology associated with MERS-CoV infection was evaluated by using formalin-fixed, paraffin embedded, and hematoxylin/eosin (H&E)-stained lung specimens harvested at day 2 p.i. We report in this study for the first time that treatment of Tg mice with a single-dose of m336 antibody prior to or after challenging with 1,000 LD 50 of MERS-CoV protected mice from the lethality in a dose-dependent manner, thereby representing the first antibody tested for its protective efficacy against lethal MERS-CoV infection.


id: cord-298941-xf2ukinp
author: Al-Abdallat, Mohammad Mousa
date: 2014-05-14
extension: .txt
mime: text/plain
words: 4829
sentence: 198
flesch: 38
cache: cache/cord-298941-xf2ukinp.txt
txt: txt/cord-298941-xf2ukinp.txt
title:
  Hospital-Associated Outbreak of Middle East Respiratory Syndrome Coronavirus: A Serologic, Epidemiologic, and Clinical Description

summary:
  Sera from the 2 fatal cases (designated outbreak subjects 01 and 12) having positive rRT-PCR tests were also tested by the 3 described serology tests. The recombinant btHKU5.2 nucleocapsid proteinbased ELISA was developed by the CDC to detect the presence of antibodies that cross-react with the HKU5.2 N protein in serum samples from possible MERS cases.


id: cord-349643-jtx7ni9b
author: Uyeki, Timothy M.
title: Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus
date: 2016-07-17
extension: .txt
mime: text/plain
words: 4808
sentence: 116
flesch: 14
cache: cache/cord-349643-jtx7ni9b.txt
txt: txt/cord-349643-jtx7ni9b.txt
summary:
  Interferon alfa-n3 for the treatment of Middle East respiratory syndrome Systematic review of treatment effects Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 Evaluation of SSYA10-001 as a replication inhibitor of SARS, MHV and MERS coronaviruses Anti-infective immunoadhesins from plants Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Anti-MERS-COV convalescent plasma therapy Cows with human chromosomes enlisted to fight hantavirus Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution A conformationdependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in MERS-CoV spike protein Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Coronaviruses-drug discovery and therapeutic options 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Evaluation of candidate vaccine approaches for MERS-CoV A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates Phase I, open label dose ranging safety study of GLS-5300 in healthy volunteers Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant modified vaccinia virus Ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus Evaluation of serologic and antigenic relationships between Middle Eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus Camels emit dangerous MERS virus, CSU confirms MERS surges again, but pandemic jitters ease Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice MERS-CoV in upper respiratory tract and lungs of dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Time course of MERS-CoV infection and immunity in dromedary camels High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in United Arab Emirates Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways International Severe Acute Respiratory and Emerging Infection Consortium. In addition, the risk for antibody-dependent enhancement of disease may interrupt the timeline for conducting human clinical trials of MERS CoV vaccines and immunotherapeutics.


id: cord-286472-pqtem19t
author: McFee, R.B.
title: MIDDLE EAST RESPIRATORY SYNDROME (MERS) CORONAVIRUS
date: 2020-07-28
extension: .txt
mime: text/plain
words: 5367
sentence: 207
flesch: 40
cache: cache/cord-286472-pqtem19t.txt
txt: txt/cord-286472-pqtem19t.txt
summary:
  Of note, co-infection with other respiratory viruses and a few cases of co-infection with communityacquired bacteria at admission has been reported in MERS CoV patients. Patients recently returning from the Middle East, presenting with significant respiratory illness, with CT findings of peribronchial region abnormalities, organizing pneumonia, should be considered for MERS CoV infection, and if possible, queried about international travel and occupational exposures.


id: cord-323428-jd91k19z
author: Ababneh, Mustafa
date: 2019-10-11
extension: .txt
mime: text/plain
words: 5739
sentence: 224
flesch: 45
cache: cache/cord-323428-jd91k19z.txt
txt: txt/cord-323428-jd91k19z.txt
title:
  Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice

summary:
  Emergence of a novel human coronavirus Middle East respiratory syndrome coronavirus MERS-CoV: Current knowledge gaps Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans MERS-CoV--are we on the verge of a pandemic? Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation Antibodies against MERS coronavirus in dromedary camels Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Severe acute respiratory syndrome vaccine efficacy in ferrets: whole killed virus and adenovirus-vectored vaccines Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus Type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant modified vaccinia virus ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th 1 and Th 2 responses against Middle East respiratory syndrome coronavirus Distribution and absence of generalized lesions in mice following single-dose intramuscular inoculation of the vaccine candidate MVA-MERS-S Immunogenicity of different forms of Middle East respiratory syndrome s glycoprotein ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection A highly immunogenic, protective and safe adenovirus-based vaccine expressing MERS-CoV S1-CD40L fusion protein in transgenic human DPP4 mouse model Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC The receptor-binding domain of MERS-CoV: The dawn of vaccine and treatment development Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats Available at www.veterinaryworld.org Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus The Gene Delivery Company): Recombinant Adenovirus Construction Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Endogenous biotin expression in renal and testicular tumors and literature review Retrieved endogenous biotin: S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime.


id: cord-332952-d5l60cgc
title: MERS: Progress on the global response, remaining challenges and the way forward
date: 2018-09-17
extension: .txt
mime: text/plain
words: 5562
sentence: 113
flesch: 13
cache: cache/cord-332952-d5l60cgc.txt
txt: txt/cord-332952-d5l60cgc.txt
summary:
  The prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) antibodies in dromedary camels in Israel Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia MERS outbreak in Korea: hospital-to-hospital transmission Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS outbreak units Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Influenza not MERS CoV among returning Hajj and Umrah pilgrims with respiratory illness Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus No MERS-CoV but positive influenza viruses in returning Hajj pilgrims, China MERS coronavirus in dromedary camel herd, Saudi Arabia Lack of Middle East respiratory syndrome coronavirus transmission from infected camels Acute respiratory infections in travelers returning from MERS-CoV-affected areas Etiology of severe community-acquired pneumonia during the 2013 Hajj-part of the MERS-CoV surveillance program Prevalence of MERS-CoV Nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications Antibodies against MERS coronavirus in dromedary camels Absence of Middle East respiratory syndrome coronavirus in Camelids Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir Infectivity of an asymptomatic patient with Middle East respiratory syndrome coronavirus infection Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study MERS coronavirus neutralizing antibodies in camels Event based surveillance of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Bangladesh among pilgrims and travelers from the Middle East: an update for the period High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels MERS-CoV outbreak in Jeddah -a link to health care facilities Group on MERS-cov Infection in Animals Infection with Coronavirus in Camels Middle East Respiratory Syndrome Coronavirus (MERS-cov) Case Definition for Reporting to OIE Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Isolation of MERS coronavirus from a dromedary camel Cross-sectional survey and surveillance for influenza viruses and MERS-CoV among Egyptian pilgrims returning from Hajj during 2012-2015 Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Specific serology for emerging human coronaviruses by protein microarray Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Serologic evidence for MERS-CoV infection in dromedary camels Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Development and validation of a rapid immunochromatographic assay for detection of Middle East respiratory syndrome coronavirus antigen in dromedary camels State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Influenza Aerosols in UK Hospitals during the H1N1 (2009) Pandemic -the Risk of Aerosol Generation during Medical Procedures Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions High prevalence of Middle East respiratory coronavirus in young dromedary camels in Jordan. Surveillance and testing for Middle East respiratory syndrome coronavirus, Saudi Arabia Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Response to emergence of Middle East respiratory syndrome coronavirus Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Acute respiratory infections among returning Hajj pilgrims-Jordan Infectious MERS-CoV isolated from a mildly Ill patient, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice Cross-sectional surveillance of Middle East R MERS-CoV) in dromedary camels and other mammals in Egypt Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt Association between Australian Hajj Pilgrims' awareness of MERS-CoV, and their compliance with preventive measures and exposure to camels Unusual presentation of Middle East respiratory syndrome coronavirus leading to a large outbreak in Riyadh during 2017 High prevalence of common respiratory viruses and no evidence of Middle East Respiratory Syndrome Coronavirus in Hajj pilgrims returning to Ghana Critically Ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study Middle East respiratory syndrome Corticosteroid therapy for critically Ill patients with Middle East respiratory syndrome Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Middle East respiratory syndrome coronavirus antibodies in dromedary camels Hospital outbreak of Middle East respiratory syndrome coronavirus Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travellers and pilgrims from the Middle East: a prospective descriptive study for the period 2013-2015 Evidence for camel-to-human transmission of MERS coronavirus Description of a hospital outbreak of Middle East respiratory syndrome in a large tertiary care hospital in Saudi Arabia Viral respiratory infections among Hajj pilgrims in 2013 Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Middle East respiratory syndrome coronavirus quasispecies that include homologues of human Isolates revealed through wholegenome analysis and virus cultured from dromedary camels in Saudi Arabia Geographic distribution of MERS coronavirus among dromedary camels MERS-CoV infection of alpaca in a region where MERS-CoV is endemic MERS coronaviruses in dromedary camels Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Antibodies against MERS coronavirus in dromedary camels Experimental infection and response to rechallenge of alpacas with Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus specific antibodies in naturally exposed Israeli llamas, alpacas and camels Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Transmission of MERS-coronavirus in household contacts An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia Toward developing a preventive MERS-CoV vaccine-report from a workshop organized by the Saudi Arabia Ministry of health and the international vaccine Institute Dromedary camels in northern Mali have high seropositivity to MERS-CoV FAO, 2014.


id: cord-345591-zwh1xj5u
author: Al-Dorzi, Hasan M.
date: 2016-10-24
extension: .txt
mime: text/plain
words: 5885
sentence: 277
flesch: 46
cache: cache/cord-345591-zwh1xj5u.txt
txt: txt/cord-345591-zwh1xj5u.txt
title:
  The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study

summary:
  The hospital mortality of ICU MERS patients was 63.4 % (0 % for the HCWs). According to the IDEP, one unit (Unit A) was designated as the primary receiving unit for MERS patients, because of its geographic location being away from main hospital traffic and because 7 of its 8 rooms were negative-pressure airborne infection isolation rooms (AIIR).


id: cord-352527-eeyqh9nc
author: Zhou, Yusen
title: Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
date: 2019-01-14
extension: .txt
mime: text/plain
words: 5878
sentence: 206
flesch: 37
cache: cache/cord-352527-eeyqh9nc.txt
txt: txt/cord-352527-eeyqh9nc.txt
summary:
  An epidemiological outbreak study Outbreak of Middle East respiratory syndrome at tertiary care hospital Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections Family cluster of Middle East respiratory syndrome coronavirus infections Healthcare-associated infections: The hallmark of Middle East respiratory syndrome coronavirus with review of the literature Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: A report of nosocomial transmission Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus Persistence of antibodies against Middle East respiratory syndrome coronavirus Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: A study protocol Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: A single centre experience Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: A phase 1 randomised, double-blind, single-dose-escalation study Prospects for a MERS-CoV spike vaccine Current advancements and potential strategies in the development of MERS-CoV vaccines Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? CoV spike protein: A key target for antivirals Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate Reverse genetics with a full-length infectious cDNA of the Middle East Report of two cases & review of the literature MERS-CoV infection in a pregnant woman in Korea Middle East respiratory syndrome coronavirus in pediatrics: A report of seven cases from Saudi Arabia Middle East respiratory syndrome coronavirus infection during pregnancy: A Report of 5 cases from Saudi Arabia An outbreak of Middle East respiratory syndrome coronavirus infection in South Korea Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) Discovery of novel bat coronaviruses in south China that use the same receptor as Middle East respiratory syndrome coronavirus Rapid detection of MERS coronavirus-like viruses in bats: Pote1ntial for tracking MERS coronavirus transmission and animal origin Receptor usage of a novel bat lineage C Betacoronavirus reveals evolution of Middle East respiratory syndrome-related coronavirus spike proteins for human dipeptidyl peptidase 4 binding MERS-CoV spillover at the camel-human interface Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation High prevalence of MERS-CoV infection in camel workers in Saudi Arabia The prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) antibodies in dromedary camels in Israel Serologic evidence for MERS-CoV infection in dromedary camels Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia Dromedary camels in northern Mali have high seropositivity to MERS-CoV Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia county Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Middle East respiratory syndrome coronavirus: Risk factors and determinants of primary, household, and nosocomial transmission Unusual presentation of Middle East respiratory syndrome coronavirus leading to a large outbreak in Riyadh during 2017 Outbreaks of Middle East respiratory syndrome in two hospitals initiated by a single patient in Daejeon MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea:


id: cord-265380-2gs34xcw
author: Leist, Sarah R.
date: 2019-09-14
extension: .txt
mime: text/plain
words: 6031
sentence: 299
flesch: 46
cache: cache/cord-265380-2gs34xcw.txt
txt: txt/cord-265380-2gs34xcw.txt
title:
  Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome

summary:
  After infection mice are monitored daily for weight loss for the entire duration of the experiment. The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts Comparative analysis of eleven healthcare-associated outbreaks of Middle East respiratory syndrome coronavirus (Mers-Cov) from Economic impact of the 2015 MERS outbreak on the Republic of Korea's tourism-related industries Costly lessons from the 2015 Middle East respiratory syndrome coronavirus outbreak in Korea Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission Middle East respiratory syndrome coronavirus transmission among health care workers: implication for infection control MERS transmission and risk factors: a systematic review High prevalence of MERS-CoV infection in camel workers in Saudi Arabia Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Severe acute respiratory syndrome Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice Origin and evolution of pathogenic coronaviruses Jumping species-a mechanism for coronavirus persistence and survival Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection-clinicopathological and ultrastructural study Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Middle East respiratory syndrome Viral load kinetics of MERS coronavirus infection The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-specific human monoclonal antibody protects rabbits from MERS-CoV infection Lack of Middle East respiratory syndrome coronavirus transmission in rabbits Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Pneumonia from human coronavirus in a macaque model Treatment with lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Infection with MERS-CoV causes lethal pneumonia in the common marmoset A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Middle East Respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with Middle East respiratory syndrome-coronavirus Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to Middle East respiratory syndrome coronavirus infection and disease CD8+ T cells and macrophages regulate pathogenesis in a mouse model of Middle East respiratory syndrome A human DPP4-Knockin Mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with Middle East respiratory syndrome coronavirus Haagmans BL (2013)


id: cord-267540-9p4rky4c
author: Joseph, Iype
title: Middle east respiratory syndrome corona virus (MERS CoV): The next steps
date: 2015-03-26
extension: .txt
mime: text/plain
words: 1708
sentence: 86
flesch: 47
cache: cache/cord-267540-9p4rky4c.txt
txt: txt/cord-267540-9p4rky4c.txt
summary:
  Such hospital environments are quite common in developing countries. Health departments of developing countries can step forward to carry out this under international coordination from WHO.


id: cord-266260-t02jngq0
author: Ramshaw, Rebecca E.
title: A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences
date: 2019-12-13
extension: .txt
mime: text/plain
words: 7243
sentence: 243
flesch: 30
cache: cache/cord-266260-t02jngq0.txt
txt: txt/cord-266260-t02jngq0.txt
summary:
  Vector Borne Zoonotic Dis Arabia: an index case investigation Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Stillbirth During Infection With Middle East Respiratory Syndrome Coronavirus Antibodies against MERS Coronavirus in Dromedary Camels MERS-CoV Antibodies in Humans, Africa No Serologic Evidence of Middle East Respiratory Syndrome Coronavirus Infection Among Camel Farmers Exposed to Highly Seropositive Camel Herds: A Household Linked Study Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update Emergence of MERS-CoV in the Middle East: origins, transmission, treatment, and perspectives Laboratory-confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Malaysia: preparedness and response Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria Asymptomatic MERS-CoV Infection in Humans Possibly Linked to Infected Dromedaries Imported from Oman to United Arab Emirates Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels The Middle East Respiratory Syndrome Coronavirus (MERS-COV) Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection from Oman to Thailand Serologic Evidence for MERS-CoV Infection in Dromedary Camels Contact tracing the first Middle East respiratory syndrome case in the Philippines Effectiveness of the Middle East respiratory syndrome-coronavirus protocol in enhancing the function of an Emergency Department in Qatar High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Isolation of MERS coronavirus from a dromedary camel MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study MERS-CoV outbreak in Jeddah-a link to health care facilities A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes A family cluster of Middle East Respiratory Syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS Acute Middle East Respiratory Syndrome Coronavirus: Temporal Lung Changes Observed on the Chest Radiographs of 55 Patients Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus An outbreak of Middle East Respiratory Syndrome (MERS) due to coronavirus in Al-Ahssa Region, Saudi Arabia Antibody Response and Disease Severity in Healthcare Worker MERS Survivors Brief Report: Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections Characteristics and Outcomes of Middle East Respiratory Syndrome Coronavirus Patients Admitted to an Intensive Care Unit in Jeddah, Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a singlecenter experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Description of a Hospital Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital in Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Evidence for camel-to-human transmission of MERS coronavirus Exposures among MERS Case-Patients First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Identified Transmission Dynamics of Middle East Respiratory Syndrome Coronavirus Infection During an Outbreak: Implications of an Overcrowded Emergency Department Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome Lack of middle East respiratory syndrome coronavirus transmission from infected camels Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East A cluster analysis with implications for global management of suspected cases Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Middle East respiratory syndrome coronavirus in children Middle East Respiratory Syndrome Coronavirus Infection During Pregnancy: A Report of 5 Cases From Saudi Arabia Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital-Riyadh, Saudi Arabia Outbreak of Middle East Respiratory Syndrome at Tertiary Care Hospital Patient characteristics infected with Middle East respiratory syndrome coronavirus infection in a tertiary hospital Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, crosssectional, serological study Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Report of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in Four Patients with Hematological Malignancies Treated at King Fahad Medical City Risk Factors for Middle East Respiratory Syndrome Coronavirus Infection among Healthcare Personnel Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome corona virus Successful recovery of MERS CoV pneumonia in a patient with acquired immunodeficiency syndrome: a case report Surveillance and Testing for Middle East Respiratory Syndrome Coronavirus, Saudi Arabia The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study The first case of the 2015 Korean Middle East Respiratory Syndrome outbreak Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Middle East respiratory syndrome coronavirus transmission among health care workers: Implication for infection control Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study The calm before the storm: clinical observations of Middle East respiratory syndrome (MERS) patients The prevalence of Middle East respiratory Syndrome coronavirus (MERS-CoV) infection in livestock and temporal relation to locations and seasons Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia Conveyance Contact Investigation for Imported Middle East Respiratory Syndrome Cases Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Outbreak of Middle East Respiratory Syndrome-Coronavirus Causes


id: cord-331228-wbd0s4fo
author: Shehata, Mahmoud M.
title: Middle East respiratory syndrome coronavirus: a comprehensive review
date: 2016-01-20
extension: .txt
mime: text/plain
words: 7527
sentence: 314
flesch: 43
cache: cache/cord-331228-wbd0s4fo.txt
txt: txt/cord-331228-wbd0s4fo.txt
summary:
  respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies Protective efficacy of recombinant Modified Vaccinia virus Ankara (MVA) delivering Middle East Respiratory Syndrome coronavirus spike glycoprotein Evaluation of candidate vaccine approaches for MERS-CoV Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Cyclophilins as modulators of viral replication Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis Testing of Middle East respiratory syndrome coronavirus replication inhibitors for the ability to block viral entry Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The newly emerged SARS-like coronavirus HCoV-EMC also has an Achilles' heel: current effective inhibitor targeting a 3C-like protease Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Mahmoud M. Shehata, Mokhtar R. Gomaa, Mohamed A. Ali, and Ghazi Kayali declare that they have no conflict of interest. respiratory syndrome coronavirus The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Inhibition of proprotein convertases abrogates processing of the middle eastern respiratory syndrome coronavirus spike protein in infected cells but does not reduce viral infectivity Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein Furin at the cutting edge: from protein traffic to embryogenesis and disease MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells SARS-beginning to understand a new virus Wildtype and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Pneumonia from human coronavirus in a macaque model Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Infection with MERS-CoV causes lethal pneumonia in the common marmoset The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits Novel coronavirus-Saudi Arabia: human isolate.


id: cord-283586-o8m6xdra
author: Spanakis, Nikolaos
date: 2014-12-31
extension: .txt
mime: text/plain
words: 3280
sentence: 129
flesch: 37
cache: cache/cord-283586-o8m6xdra.txt
txt: txt/cord-283586-o8m6xdra.txt
title:
  Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

summary:
  Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Clinical Decision Making Tool for Treatment of MERS-CoV v A case of imported Middle East respiratory syndrome coronavirus infection and public health response Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Ribavirin and interferon (IFN)-␣-2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus (MERS-CoV): a preliminary report of two cases Treatment with interferon-␣2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Schering Corp Product information. Switzerland: WHO Long-term SARS coronavirus excretion from patient cohort Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential Interferon-␤ and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Inhibition of novel ␤ coronavirus replication by a combination of interferon-␣2b and ribavirin In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) coronavirus infection Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Hospital outbreak of Middle East


id: cord-287761-73qgx58i
author: Aly, Mahmoud
date: 2017-10-13
extension: .txt
mime: text/plain
words: 3394
sentence: 133
flesch: 50
cache: cache/cord-287761-73qgx58i.txt
txt: txt/cord-287761-73qgx58i.txt
title:
  Occurrence of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) across the Gulf Corporation Council countries: Four years update

summary:
  Next, we sought out the detailed demographic distributions of reported cases among 14 governorates in Saudi Arabia. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an invitro and ex-vivo study Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Infection control and MERS-CoV in health-care workers MERS coronovirus has probably been present in bats for many years, research shows Link to MERS virus underscores bats' puzzling threat Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronavirus neutralizing antibodies in camels Animal models of Middle East respiratory syndrome coronavirus infection MERS-CoV


id: cord-255488-nvgz53su
author: Li, Kun
title: Development of a Mouse-Adapted MERS Coronavirus
date: 2019-09-14
extension: .txt
mime: text/plain
words: 2949
sentence: 169
flesch: 58
cache: cache/cord-255488-nvgz53su.txt
txt: txt/cord-255488-nvgz53su.txt
summary:
  Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Person-toperson spread of the MERS coronavirus-an evolving picture The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Spread of MERS to South Korea and China Infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the Middle East respiratory syndrome coronavirus (MERS-CoV) Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Pathogenicity and viral shedding of MERS-CoV in immunocompromised rhesus macaques Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease Infection with MERS-CoV causes lethal pneumonia in the common marmoset Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East Coronavirus DOI: 10.1007/978-1-0716-0211-9_13 sha: doc_id: 255488 cord_uid: nvgz53su First identified in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that can cause acute respiratory distress syndrome (ARDS), multiorgan failure, and death, with a case fatality rate of ~35%.


id: cord-316392-bp988sir
author: Kupfer, Bernd
title: Severe Pneumonia and Human Bocavirus in Adult
date: 2006-10-17
extension: .txt
mime: text/plain
words: 1663
sentence: 58
flesch: 38
cache: cache/cord-316392-bp988sir.txt
txt: txt/cord-316392-bp988sir.txt
summary:
  Recently, evidence of human bocavirus infection was reported for 3.1% to 5.7% of children <3 years of age (1) (2) (3) . This finding led to the conclusion that a new virus that induces the identical clinical symptoms, like the human bocavirus, may also contribute to severe respiratory infections.


id: cord-022046-q1exf47s
author: Toosy, Arshad Haroon
title: An Overview of Middle East Respiratory Syndrome in the Middle East
date: 2018-09-28
extension: .txt
mime: text/plain
words: 2929
sentence: 114
flesch: 43
cache: cache/cord-022046-q1exf47s.txt
txt: txt/cord-022046-q1exf47s.txt
summary:
  Available at An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus in bats, Saudi Arabia MERS coronaviruses in dromedary camels Middle East respiratory syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Antibodies against MERS coronavirus in dromedaries Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Isolation of MERS Coronavirus from a Dromedary Camel MERS-CoV in upper respiratory tract and lungs of dromedary camels, Saudi Arabia 5, 10 The temporal dynamics of MERS infection in DCs in Al-Ahsa, KSA, was examined by collecting nasal swabs and lung tissue during postmortem examination from two independent groups of animals over the course of a year and testing these for MERS-CoV RNA by real-time reverse-transcriptase polymerase chain reaction (RT-rtPCR).


id: cord-329190-kv9n2qj3
author: Rabaan, Ali A.
title: A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective
date: 2017-09-01
extension: .txt
mime: text/plain
words: 8912
sentence: 420
flesch: 43
cache: cache/cord-329190-kv9n2qj3.txt
txt: txt/cord-329190-kv9n2qj3.txt
summary:
  www.inovio.com/products/ infectious-disease-vaccines/mers A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates MERS-CoV vaccine candidates in development: the current landscape Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Toll-Like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment Inhibition of novel b coronavirus replication by a combination of interferon-a2b and ribavirin Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques Bioinformatics analysis on molecular mechanism of Ribavirin and interferon-a in treating MERS-CoV Treatment with lopinavir/ritonavir or interferon-b1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Middle Eastern Respiratory syndrome Corona virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome coronavirus S protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design Small molecules targeting severe acute respiratory syndrome human coronavirus Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Towards improving clinical management of Middle East respiratory syndrome coronavirus infection Ninth Report of the International Committee on Taxonomy of Viruses Cross host transmission in the emergence of MERS coronavirus Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat Close relative of human Middle East respiratory syndrome coronavirus in bat MERS-Coronavirus molecular epidemiology and genetic analysis -Origin and evolution MERS coronavirus: diagnostics, epidemiology and transmission Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics Evolutionary dynamics of MERS-CoV: potential recombination, positive selection and transmission MERS-CoV spike protein: a key target for antivirals Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission Protease inhibitors targeting coronavirus and filovirus entry Critical assessment of the important residues involved in the dimerization and catalysis of MERS Coronavirus Main protease Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome Coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways Adjunctive therapies and immunomodulating agents for severe influenza Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis SARS: systematic review of treatment effects Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol Treatment strategies for Middle East respiratory syndrome coronavirus Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Evaluation of candidate vaccine approaches for MERS-CoV A conformationdependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Passive transfer of A Germline-like neutralizing human monoclonal antibody protects transgenic mice against Lethal Middle East respiratory syndrome coronavirus infection Prophylaxis with a Middle East respiratory syndrome coronavirus (MERS-CoV)-Specific human monoclonal antibody protects rabbits from MERS-CoV infection Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012 Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeatderived peptides Protective effect of intranasal regimens containing peptidic Middle East respiratory syndrome coronavirus fusion inhibitor against MERS-CoV infection A truncated receptorbinding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: implication for designing novel mucosal MERS vaccines Receptor-binding domain-based subunit vaccines against MERS-CoV Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus Recombinant receptor-binding domains of multiple Middle East respiratory syndrome coronaviruses (MERS-CoVs) induce cross-neutralizing antibodies against divergent human and camel MERS-CoVs and antibody escape mutants Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice Toward developing a preventive MERS-CoV Vaccine-Report from a workshop organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute Protective efficacy of recombinant modified vaccinia virus Ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus A highly immunogenic and protective Middle East respiratory syndrome coronavirus vaccine based on a recombinant measles virus vaccine platform An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels GLS-5300 SynCon® immunotherapy targeting Middle East Respiratory Syndrome.


id: cord-319877-izn315hb
author: de Wit, Emmie
title: SARS and MERS: recent insights into emerging coronaviruses
date: 2016-06-27
extension: .txt
mime: text/plain
words: 9406
sentence: 277
flesch: 31
cache: cache/cord-319877-izn315hb.txt
txt: txt/cord-319877-izn315hb.txt
summary:
  Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-κB signaling Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage A two-pronged strategy to suppress host protein synthesis by SARS coronavirus nsp1 protein Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain Middle East respiratory syndrome coronavirus nsp1 inhibits host gene expression by selectively targeting mRNAs transcribed in the nucleus while sparing mRNAs of cytoplasmic origin Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists MAVS-mediated apoptosis and its inhibition by viral proteins Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses Mechanisms of action of ribavirin against distinct viruses Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Clinical analysis of the first patient with imported Middle East respiratory syndrome in China Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Identification of severe acute respiratory syndrome in Canada Development of a standard treatment protocol for severe acute respiratory syndrome A cluster of cases of severe acute respiratory syndrome in Hong Kong Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR Severe acute respiratory syndrome (SARS) in Singapore: clinical features of index patient and initial contacts Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques The first application of a potential treatment option for MERS through the repurposing of IFNα2b and ribavirin in a non-human primate model Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a non-human primate model of common marmoset Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Combination therapy with lopinavir/ ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report Clinical implications of five cases of Middle East respiratory syndrome coronavirus infection in South Korea Outbreak From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug design Thiopurine analogs and mycophenolic acid synergistically inhibit the papainlike protease of Middle East respiratory syndrome coronavirus Ligand-induced dimerization of Middle East respiratory syndrome (MERS) coronavirus nsp5 protease (3CL pro ): implications for nsp5 regulation and the development of antivirals Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture International Severe Acute Respiratory & Emerging Infection Consortium. WHO Nidovirus transcription: how to make sense…? Coronaviruses post-SARS: update on replication and pathogenesis Coronaviruses: an overview of their replication and pathogenesis SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage Infidelity of SARS-CoV nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS Middle East respiratory syndrome coronavirus neutralizing serum antibodies in dromedary camels: a comparative serological study Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Evidence for camel-to-human transmission of MERS coronavirus MERS coronavirus in dromedary camel herd, Saudi Arabia Isolation of MERS coronavirus from a dromedary camel Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study An analysis of the predominant role for nosocomial transmission in the epidemiology of both SARS and MERS Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study A description of the clinical representation of SARS-CoV respiratory disease in patients from Hong Kong Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Evidence that infectious MERS-CoV can be detected on common hospital surfaces during an outbreak, which highlights the potential for nosocomial transmission and stresses the need for infection control The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Middle East respiratory syndrome coronavirus superspreading event involving 81 persons the role of super-spreaders in infectious disease Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases Biomarkers in acute respiratory distress syndrome The mercurial nature of neutrophils: still an enigma in ARDS? SARS-CoV virus-host interactions and comparative etiologies of acute respiratory distress syndrome as determined by transcriptional and cytokine profiling of formalin-fixed paraffin-embedded tissues Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Genome wide identification of SARS-CoV susceptibility loci using the Collaborative Cross Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV Rapid generation of a mouse model for Middle East respiratory syndrome A study in which the DPP4-based host restriction is overcome in mice by expression of the human variant of DPP4, leading to the development of several transgenic mouse models MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex


id: cord-272513-umuiovrd
author: Bindayna, Khalid Mubarak
title: Variant analysis of SARS-CoV-2 genomes in the Middle East
date: 2020-10-09
extension: .txt
mime: text/plain
words: 3034
sentence: 159
flesch: 54
cache: cache/cord-272513-umuiovrd.txt
txt: txt/cord-272513-umuiovrd.txt
summary:
  key: cord-272513-umuiovrd authors: Bindayna, Khalid Mubarak; Crinion, Shane title: Variant analysis of SARS-CoV-2 genomes in the Middle East date: 2020-10-09 journal: bioRxiv DOI: 10.1101/2020.10.09.332692 sha: doc_id: 272513 cord_uid: umuiovrd Background Coronavirus (COVID-19) was introduced into society in late 2019 and has now reached over 26 million cases and 850,000 deaths. If we explore the structure and common variants of SARS-CoV-2 strains in these populations, we expect to learn more about how the virus spread.


id: cord-269232-rhhmvnlp
author: Joseph, Sunitha
title: First isolation of West Nile virus from a dromedary camel
date: 2016-06-08
extension: .txt
mime: text/plain
words: 3167
sentence: 121
flesch: 50
cache: cache/cord-269232-rhhmvnlp.txt
txt: txt/cord-269232-rhhmvnlp.txt
summary:
  15 Tissue culture cell extracts infected with dromedary WNV were centrifuged at 19 000g at 4°C. West Nile virus in a dromedary S Joseph et al Viral diseases of new world camelids A transversal study on antibodies against selected pathogens in dromedary camels in the Canary Islands Rift Valley and West Nile virus antibodies in camels Emerging viral diseases in dromedary camels in the Southern Morocco Seroepidemiological studies for the detection of antibodies against nine infectious diseases in dairy dromedaries (Part-1) Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia A phylogenetically distinct Middle East respiratory syndrome coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence with age A sensitive and specific antigen detection assay for Middle East


id: cord-305317-08a1oin2
author: Maltezou, Helena C.
title: Middle East respiratory syndrome coronavirus: Implications for health care facilities
date: 2014-12-31
extension: .txt
mime: text/plain
words: 3647
sentence: 163
flesch: 46
cache: cache/cord-305317-08a1oin2.txt
txt: txt/cord-305317-08a1oin2.txt
summary:
  Ninth update Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Middle East respiratory syndrome coronavirus infections in health care workers First confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the United States, updated information on the epidemiology of MERS-CoV infection, and guidance for the public, clinicians, and public health authorities Hospital-associated outbreak of Middle East Respiratory Syndrome coronavirus: a serologic, epidemiologic, and clinical description A case of imported Middle East respiratory syndrome coronavirus infection and public health response Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Prediction of intrinsic disorder in MERS-CoV/ HCoV-EMC supports a high oral-fecal transmission Severe respiratory illness caused by a novel coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Contact investigation of a case of human novel coronavirus infection treated in a German hospital Current advancements and potential strategies in the development of MERS-CoV vaccines Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus (MERS-CoV) Preventing the spread of influenza A H1N1 2009 to health-care workers Illinois resident who had contact with Indiana MERS patient tests positive for MERS coronavirus Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Hospital outbreak of Middle East respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus (MERS-CoV) e update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature updateeas of 9 Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia European Centre for Disease Prevention and Control.


id: cord-318585-cp76qr9f
author: Matsuyama, Ryota
date: 2016-11-29
extension: .txt
mime: text/plain
words: 4500
sentence: 180
flesch: 43
cache: cache/cord-318585-cp76qr9f.txt
txt: txt/cord-318585-cp76qr9f.txt
title:
  Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis

summary:
  These risks showed a substantial heterogeneity among the identified studies, and appeared to be the highest in case studies focusing on ICU cases. In ICU case studies, the expected odds ratios (OR) of death among patients with underlying heart disease or renal disease to patients without such comorbidities were 0.6 (95% Confidence Interval (CI): 0.1, 4.3) and 0.6 (95% CI: 0.0, 2.1), respectively, while the ORs were 3.8 (95% CI: 3.4, 4.2) and 2.4 (95% CI: 2.0, 2.9), respectively, in studies with other types of designs.


id: cord-307995-8q7efrqk
author: Al-Tawfiq, Jaffar A.
title: Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
date: 2016-05-04
extension: .txt
mime: text/plain
words: 4444
sentence: 225
flesch: 51
cache: cache/cord-307995-8q7efrqk.txt
txt: txt/cord-307995-8q7efrqk.txt
summary:
  Mitigation through Detection, Research, and Response Saudi Arabia and the emergence of a novel coronavirus Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia An update on Middle East respiratory syndrome: 2 years later Health care worker contact with MERS patient, Saudi Arabia Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Middle East respiratory syndrome coronavirus case definition for reporting to WHO: interim case definition 14 Middle East respiratory syndrome coronavirus: epidemiology and disease control measures Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Family cluster of Middle East respiratory syndrome coronavirus infections A family cluster of Middle East Respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case Community case clusters of Middle East respiratory syndrome coronavirus in Hafr Al-Batin, Kingdom of Saudi Arabia: a descriptive genomic study Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study KSA MERS-CoV Investigation Team. Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia Imported cases of Middle East respiratory syndrome: an update The Hajj pilgrimage and surveillance for Middle East Respiratory syndrome coronavirus in pilgrims from African countries High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia Transmission of MERS-coronavirus in household contacts Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Heat inactivation of the Middle East respiratory syndrome coronavirus Infection prevention and control of epidemic-and pandemic prone acute respiratory infections in health care Interim infection prevention and control recommendations for hospitalized patients with Middle East respiratory syndrome coronavirus Treating MERS-CoV during an outbreak Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)-possible lessons from a systematic review of SARS-CoV therapy Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Inhibition of novel coronavirus replication by a combination of interferon-α2b and ribavirin Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Combination therapy with lopinavir/ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome: a case report


id: cord-295633-vkjcheaz
author: Hao, Xin‐yan
date: 2019-10-30
extension: .txt
mime: text/plain
words: 5112
sentence: 177
flesch: 41
cache: cache/cord-295633-vkjcheaz.txt
txt: txt/cord-295633-vkjcheaz.txt
title:
  The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose‐only exposure device

summary:
  Vector Borne Zoonotic Dis Intranasal influenza infection of mice and methods to evaluate progression and outcome Comparison of traditional intranasal and aerosol inhalation inoculation of mice with influenza A viruses A mouse model for MERS coronavirus-induced acute respiratory distress syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Mouseadapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice Distribution of aerosols in mouse lobes by fluorescent imaging Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with middle east respiratory syndrome-coronavirus An acute immune response to Middle East respiratory syndrome coronavirus replication contributes to viral pathogenicity Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis SARS and other coronaviruses as causes of pneumonia Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Association between severity of MERS-CoV infection and incubation period Clinical implication of radiographic scores in acute Middle East respiratory syndrome coronavirus pneumonia: report from a single tertiary-referral center of South Korea Mortality rate of ICU patients with the Middle East respiratory syndrome -coronavirus infection at King Fahad Hospital Middle East respiratory syndrome Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 A human DPP4-Knockin mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV One Health Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC A rapid scoping review of Middle East respiratory syndrome coronavirus in animal hosts Clinical and biological character in mouse models for Middle East respiratory syndrome generated by transduction with different doses of DPP4 molecule Elevated human dipeptidyl peptidase 4 expression reduces the susceptibility of hDPP4 transgenic mice to Middle East respiratory syndrome coronavirus infection and disease Acute respiratory infection in human dipeptidyl peptidase 4-transgenic mice infected with Middle East respiratory syndrome coronavirus Emergencies preparedness, response.


id: cord-256806-g42n51n9
author: Khudhair, Ahmed
date: 2019-05-17
extension: .txt
mime: text/plain
words: 4412
sentence: 154
flesch: 38
cache: cache/cord-256806-g42n51n9.txt
txt: txt/cord-256806-g42n51n9.txt
title:
  Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014–2017

summary:
  Previous studies of workers with occupational exposure to camels have reported either lower seropositivity rates (e.g., 6.8% of 294 workers with occupational camel contact seropositive in Qatar [21] and 2.3% of 87 camel shepherds seropositive in Saudi Arabia [20] ) or comparable seropositivity (e.g., 53% of camel workers positive in Saudi Arabia [22] ). WHO MERS-CoV global summary and assessment of risk Middle East respiratory syndrome coronavirus (MERS-CoV) origin and animal reservoir Middle East respiratory syndrome coronavirus (MERS-CoV): animal to human interaction Risk factors for MERS coronavirus infection in dromedary camels in MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Antibodies against MERS coronavirus in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE Risk factors for primary Middle East Respiratory syndrome coronavirus illness in humans, Saudi Arabia Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Occupational exposure to dromedaries and risk for MERS-CoV infection High prevalence of MERS-CoV infection in camel workers in Saudi Arabia Inovio Pharmaceuticals I. Inovio's MERS vaccine generates high levels of antibodies and induces broad-based T Cell responses in phase 1 study Man in Germany dies of complications stemming from Mers virus Diversity of Middle East respiratory syndrome coronaviruses in 109 dromedary camels based on full-genome sequencing Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Korean Society of Infectious Diseases.


id: cord-263016-28znb322
author: Omrani, A.S.
title: Middle East respiratory syndrome coronavirus (MERS-CoV): what lessons can we learn?
date: 2015-08-22
extension: .txt
mime: text/plain
words: 4493
sentence: 193
flesch: 41
cache: cache/cord-263016-28znb322.txt
txt: txt/cord-263016-28znb322.txt
summary:
  What travel health advice should be given to Hajj pilgrims Preventive measures against MERS-CoV for Hajj pilgrims The Hajj pilgrimage and surveillance for Middle East respiratory syndrome coronavirus in pilgrims from African countries Potential for the international spread of Middle East respiratory syndrome in association with mass gatherings in Saudi Arabia Lack of nasal carriage of novel corona virus (HCoV-EMC) in French Hajj pilgrims returning from the Hajj 2012, despite a high rate of respiratory symptoms Lack of MERS coronavirus but prevalence of influenza virus in French pilgrims after Prevalence of MERS-CoV nasal carriage and compliance with the Saudi health recommendations among pilgrims attending the 2013 Hajj From the Hajj: it's the flu, idiot High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana Circulation of respiratory viruses among pilgrims during the 2012 Hajj pilgrimage Saudi Arabia, South Korea Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea Lessons to learn from MERS-CoV outbreak in South Korea Spread of MERS to South Korea and China List of hospitals with known MERS exposure Preliminary data from sequencing of viruses in the Republic of Korea and the People's Republic of China. Archive Number Severe respiratory illness caused by a novel coronavirus First cases of Middle East respiratory syndrome coronavirus (MERS-CoV) investigations and implications for the prevention of human-to-human transmission A case of imported Middle East respiratory syndrome coronavirus infection and public health response Middle East respiratory syndrome coronavirus (MERS-CoV) infections in two returning travellers in the Netherlands Lack of transmission among close contacts of patient with case of Middle East respiratory syndrome imported into the United States Spread, circulation, and evolution of the Middle East


id: cord-260518-mswb3q67
author: Zumla, Alimuddin
date: 2016-06-15
extension: .txt
mime: text/plain
words: 4040
sentence: 143
flesch: 36
cache: cache/cord-260518-mswb3q67.txt
txt: txt/cord-260518-mswb3q67.txt
title:
  Taking forward a ‘One Health’ approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential

summary:
  Since the Kingdom of Saudi Arabia is host to millions of pilgrims each year travelling from all continents, 29 tackling the threat of MERS and other infectious diseases with epidemic potential will require enhanced closer cooperation between those who provide human health, animal health, and environmental health services, locally, nationally, regionally, and internationally: the Middle Eastern, European, African, Asian, and American governments, veterinary groups, the WHO, the Food and Agriculture Organization (FAO), the African Union, the United Nations International Children's Emergency Fund (UNICEF), The World Bank, Office International des Epizooties (OIE), CDC, Public Health England, the newly formed Africa CDC, and funding agencies among others. However, MERS-CoV remains a major global public health threat with continuing reports of new human MERS cases in Saudi Arabia, where millions of pilgrims from over 184 countries travel throughout the year.


id: cord-329514-dnh3rx0q
author: Kurono, Yuichi
title: Middle Ear and Eustachian Tube
date: 2007-05-09
extension: .txt
mime: text/plain
words: 5340
sentence: 188
flesch: 31
cache: cache/cord-329514-dnh3rx0q.txt
txt: txt/cord-329514-dnh3rx0q.txt
summary:
  Although the involvement of these defensins in the defense of the eustachian tube and middle ear is yet to be proven, the potent microbicidal properties of defensins induced in the human middle ear epithelial cell line suggests that they may play a role in the pathogenesis of OM. Mucins are high-molecular-weight glycoproteins that constitute the major component of mucus secretions in all mucosal surfaces including the eustachian tube and middle ear.


id: cord-275602-cog4nma0
author: Watkins, Kevin
title: Emerging Infectious Diseases: a Review
date: 2018-06-22
extension: .txt
mime: text/plain
words: 4676
sentence: 255
flesch: 47
cache: cache/cord-275602-cog4nma0.txt
txt: txt/cord-275602-cog4nma0.txt
summary:
  Emerging infectious diseases: a CDC perspective Emerging infectious diseases in 2012: 20 years after the Institute of Medicine Report Emerging infectious disease: a proactive approach A novel coronavirus associated with severe acute respiratory syndrome Severe acute respiratory syndrome (SARS): a review of the history, epidemiology, prevention, and concerns for the future Severe acute respiratory syndrome and coronavirus Severe acute respiratory syndrome (SARS) Severe acute respiratory syndrome and influenza: virus incursions from southern China WHO guidelines for the global surveillance of severe acute respiratory syndrome (SARS) Anti-SARS coronavirus agents: a patent review (2008-present) Middle East respiratory syndrome coronavirus: a comprehensive review Middle East respiratory syndrome: what clinicians need to know Middle East respiratory syndrome coronavirus: update for clinicians This article gives the majority of a summary of perhaps most significant recent emerging infectious disease in terms of both mortality and number of cases Middle East respiratory syndrome coronavirus disease is rare in children: an update from Saudi Arabia Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Infection Prevention and Control Guidelines for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus A review of treatment modalities for Middle East respiratory syndrome Treatment outcomes for patients with middle eastern respiratory syndrome coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia A new Phlebovirus associated with severe febrile illness in Missouri Notes from the field: heartland virus disease-United States Heartland virus associated death in Tennessee Update and commentary on four emerging tick-borne infections Novel Thogotovirus associated with febrile illness and death Bourbon virus in field-collected ticks Nipah encephalitis-an update The pandemic potential of Nipah virus Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody Emergomyces canadensis, a dimorphic fungus causing fatal systemic human disease in North America Emergomyces: a new genus of dimorphic fungal pathogens causing disseminated disease among immunocompromised persons globally Global spread of antibiotic resistance: the example of New Delhi metallo-ß-lactamase (NDM)-mediated carbapenem resistance The new medical challenge: why NDM-1? The Centers for Disease Control and Prevention (CDC) recommends evaluation for patients with respiratory symptoms and travel to an affected country within 14 days or for those who are in a cluster of patients with severe acute respiratory disease in which MERS-CoV is being evaluated [14] .


id: cord-314651-e4uaw5fy
author: Zhao, Guangyu
date: 2015-12-23
extension: .txt
mime: text/plain
words: 4174
sentence: 144
flesch: 38
cache: cache/cord-314651-e4uaw5fy.txt
txt: txt/cord-314651-e4uaw5fy.txt
title:
  Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

summary:
  Systemic inflammation is believed to be a primary reason for the severe outcome in MERS--CoV infections [14, 24] . To evaluate MERS-CoV infection in the hDPP4 transgenic mice, distribution of the viral antigen NP protein was assessed in mouse tissues by immunohistochemical staining.


id: cord-016451-k8m2xz0e
author: Chertow, Daniel S.
title: Influenza, Measles, SARS, MERS, and Smallpox
date: 2020-01-03
extension: .txt
mime: text/plain
words: 6148
sentence: 284
flesch: 36
cache: cache/cord-016451-k8m2xz0e.txt
txt: txt/cord-016451-k8m2xz0e.txt
summary:
  The timeline of influenza virus shedding in children and adults in a household transmission study of influenza in Managua Long-term shedding of influenza virus, parainfluenza virus, respiratory syncytial virus and nosocomial epidemiology in patients with hematological disorders Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature Influenza virus-induced lung injury: pathogenesis and implications for treatment The pathology of influenza virus infections Bacterial coinfection in influenza: a grand rounds review Human infection with highly pathogenic avian influenza A(H7N9) virus, China Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif Immunobiology of influenza vaccines Airborne transmission of measles in a physician's office Measles virus host invasion and pathogenesis Pathological consequences of systemic measles virus infection Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques The clinical significance of measles: a review The basic reproduction number (R0) of measles: a systematic review Early waning of maternal measles antibodies in era of measles elimination: longitudinal study Measles virus-induced suppression of immune responses Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality Evidence of airborne transmission of the severe acute respiratory syndrome virus Model parameters and outbreak control for SARS Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Multiple organ infection and the pathogenesis of SARS Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Seasonal influenza virus infection is largely limited to the respiratory tract; however, H5 and H7 HPAI viruses have a polybasic cleave site within the hemagglutinin allowing for replication outside of the respiratory tract [65, 66] .


id: cord-278238-w1l8h8g8
author: Okba, Nisreen MA
title: Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches
date: 2017-04-13
extension: .txt
mime: text/plain
words: 5103
sentence: 178
flesch: 33
cache: cache/cord-278238-w1l8h8g8.txt
txt: txt/cord-278238-w1l8h8g8.txt
summary:
  key: cord-278238-w1l8h8g8 authors: Okba, Nisreen MA; Raj, V Stalin; Haagmans, Bart L title: Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches date: 2017-04-13 journal: Curr Opin Virol DOI: 10.1016/j.coviro.2017.03.007 sha: doc_id: 278238 cord_uid: w1l8h8g8 Middle East respiratory syndrome coronavirus (MERS-CoV) is a cause of severe respiratory infection in humans, specifically the elderly and people with comorbidities. Noteworthy to mention is Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches Okba, Raj and Haagmans 51 Ad/hDPP4-mice, mice transduced with hDPP4 in an adenoviral vector; alum, aluminum hydroxide; E, envelope protein; hDPP4, human dipeptidyl peptidase 4; i.m., intramuscular; i.n., intranasal; M, matrix protein; MERS-CoV, Middle East respiratory syndrome coronavirus; Nab, neutralizing antibodies; ND, not done; NHP, non-human primate; rNTD, recombinant N-terminal domain; RBD, receptor-binding domain; rRBD, recombinant RBD; RBD-Fc, RBD fused to the antibody crystallizable fragment of human IgG; S, spike protein; S1, S1 domain of spike protein; S367-606, amino acid residues 367-606 of the S protein; S736-761-KLH, peptide S736-761 coupled to keyhole limpet haemocyanin; s.c., subcutaneous; VLPs, Virus-like particles; a i.m.;alum/CpG ODN produced higher neutralizing antibody responses than s.c.; IFA/CpG ODN.


id: cord-337825-ujq9mxk7
author: Chen, Bin
title: Overview of lethal human coronaviruses
date: 2020-06-10
extension: .txt
mime: text/plain
words: 13457
sentence: 535
flesch: 43
cache: cache/cord-337825-ujq9mxk7.txt
txt: txt/cord-337825-ujq9mxk7.txt
summary:
  lung injury Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14 +CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus Characterization of novel monoclonal antibodies against MERScoronavirus spike protein Discovery of hydrocarbon-stapled short α-helical peptides as promising Middle East respiratory syndrome coronavirus (MERS-CoV) fusion inhibitors A systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus (MERS-CoV) Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay Current treatment options and the role of peptides as potential therapeutic components for Middle East respiratory syndrome (MERS): a review Cell therapy in acute respiratory distress syndrome Challenges and responses in human vaccine development Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine Expression of B subunit of E. coli heat-labile enterotoxin in the progenies of transgenic tobacco bred by crossing nuclear-and chloroplast-transgenic lines Immunogenicity of an adenoviral-based Middle East respiratory syndrome coronavirus vaccine in BALB/c mice One-Health: a safe, efficient, dual-use vaccine for humans and animals against Middle East respiratory syndrome coronavirus and rabies virus Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation DNA vaccine of SARS-Cov S gene induces antibody response in mice ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments-the importance of immunofocusing in subunit vaccine design Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease Structural modeling of 2019-novel coronavirus (nCoV) spike protein reveals a proteolytically-sensitive activation loop as a distinguishing feature compared to SARS-CoV and related SARS-like coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Disulfiram can inhibit MERS and SARS coronaviruspapain-like proteases via different modes De novo design of α-helical lipopeptides targeting viral fusion proteins: a promising strategy for relatively broad-spectrum antiviral drug discovery Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor New vaccine technologies to combat outbreak situations Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial Potent binding of 2019 novelcoronavirus spike protein by a SARS coronavirus-specific human monoclonalantibody Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies Exceptionally potent neutralizationof Middle East respiratory syndrome coronavirus by human monoclonalantibodies Interaction between heptad repeat 1 and 2 regions inspike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors Fusion mechanism of 2019-nCoV andfusion inhibitors targeting HR1 domain in spike protein The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant No. 31870836), and the 1.3.5 Project for Disciplines Excellence, West China Hospital, Sichuan University (ZYYC20005 to W.C.). Epidemiology, genetic recombination, and pathogenesis of coronaviruses Origins and evolution of the global RNA virome Classify viruses-the gain is worth the pain Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease Human coronaviruses: what do they cause? Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS A pneumonia outbreak associated with a new coronavirus of probable bat origin Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV On the origin and continuing evolution of SARS-CoV-2 Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Mutations, recombination and insertion in the evolution of 2019-nCoV SARS and MERS: recent insights into emerging coronaviruses Global epidemiology of bat coronaviruses From SARS to MERS, thrusting coronaviruses into the spotlight Challenges presented by MERS corona virus, and SARS corona virus to global health Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease MERS-CoV as an emerging respiratory illness: a review of prevention methods The Middle East respiratory syndrome (MERS)


id: cord-299519-hfgmmuy6
author: Alenazi, Thamer H.
title: Severe Middle East Respiratory Syndrome (MERS) Pneumonia
date: 2019-10-26
extension: .txt
mime: text/plain
words: 5553
sentence: 208
flesch: 41
cache: cache/cord-299519-hfgmmuy6.txt
txt: txt/cord-299519-hfgmmuy6.txt
summary:
  Post-mortem autopsies were rarely performed on MERS patients due to cultural reasons in the Arabian Peninsula. A study that compared 330 critically ill MERS-CoV infected patients with 220 critically ill patients with non-MERS severe acute respiratory infection (SARI) found that MERS patients were younger than non-MERS SARI patients (median [Q1, Q3] 58


id: cord-349287-mwj2qby4
author: Mackay, Ian M.
title: MERS coronavirus: diagnostics, epidemiology and transmission
date: 2015-12-22
extension: .txt
mime: text/plain
words: 14293
sentence: 570
flesch: 47
cache: cache/cord-349287-mwj2qby4.txt
txt: txt/cord-349287-mwj2qby4.txt
summary:
  There are human MERS cases that do not fall into either category of source and it is unclear if these acquired infection through some entirely separate route, or from cases that escaped diagnosis. However, on occasion, even LRT specimens from MERS cases may initially be negative, only to later become positive by RT-PCR [95] .


id: cord-256784-wfaqim7d
author: Modjarrad, Kayvon
title: MERS-CoV vaccine candidates in development: The current landscape
date: 2016-06-03
extension: .txt
mime: text/plain
words: 3339
sentence: 122
flesch: 34
cache: cache/cord-256784-wfaqim7d.txt
txt: txt/cord-256784-wfaqim7d.txt
summary:
  Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Preand postexposure efficacy of fully human antibodies against spike protein in a novel humanized mouse model of MERS-CoV infection Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Family cluster of Middle East respiratory syndrome coronavirus infections Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Hospital outbreak of Middle East respiratory syndrome coronavirus Hospital-associated Middle East respiratory syndrome coronavirus infections Hospital-associated Middle East respiratory syndrome coronavirus infections Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health Hendra virus An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels Rapid generation of a mouse model for Middle East respiratory syndrome Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease Animal models of Middle East respiratory syndrome coronavirus infection Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia epidemiological findings from a retrospective investigation East Respiratory Syndrome Coronavirus (MERS-CoV) Summary and Literature Update-as of 11 Update: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea A decade after SARS: strategies for controlling emerging coronaviruses Detection of coronaviruses in bats of various species in Italy Diversity of coronavirus in bats from Eastern Thailand MERS-related betacoronavirus in Vespertilio superans bats Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai Antibodies against MERS coronavirus in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Evidence for camel-to-human transmission of MERS coronavirus MERS: emergence of a novel human coronavirus Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody Update: severe respiratory illness associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-worldwide Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques Middle East respiratory syndrome novel corona MERS-CoV infection.


id: cord-330343-p7a8chn4
author: Kelly-Cirino, Cassandra
title: An updated roadmap for MERS-CoV research and product development: focus on diagnostics
date: 2019-02-01
extension: .txt
mime: text/plain
words: 5814
sentence: 170
flesch: 26
cache: cache/cord-330343-p7a8chn4.txt
txt: txt/cord-330343-p7a8chn4.txt
summary:
  WHO MERS-COV R&D Blueprint Plan of Action R&D Blueprint for action to prevent epidemics Progress on the global response, remaining challenges and the way forward Evidence for camel-tohuman transmission of MERS coronavirus Human-dromedary camel interactions and the risk of acquiring zoonotic middle east respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt MERS coronaviruses in dromedary camels Geographic distribution of MERS coronavirus among dromedary camels Middle East Respiratory Syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan Absence of Middle East Respiratory Syndrome Coronavirus in Camelids Antibodies against MERS coronavirus in dromedary camels Serological Evidence of MERS-CoV Antibodies in Dromedary Camels (Camelus dromedaries) in Laikipia County Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia Longitudinal study of Middle East Respiratory Syndrome coronavirus infection in dromedary camel herds in Saudi Arabia Middle East Respiratory Syndrome (MERS) coronavirus seroprevalence in domestic livestock in Saudi Arabia Lack of middle East respiratory syndrome coronavirus transmission from infected camels MERS coronavirus in dromedary camel herd, Saudi Arabia Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Dromedary camels in northern Mali have high seropositivity to MERS-CoV Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels Serologic Evidence for MERS-CoV Infection in Dromedary Camels Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation MERS-CoV situation update, Map 1. MERS-CoV livestock field surveys by country Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate Middle East respiratory syndrome coronavirus antibody reactors among camels in Dubai Identification of diverse viruses in upper respiratory samples in dromedary camels from United Arab Emirates MERS CoV: OIE -World organisation for animal health Occupational exposure to dromedaries and risk for MERS-CoV Infection Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Infection in Camel Workers in Qatar During 2013-2014: A Case-Control Study Middle East Respiratory Syndrome (MERS) | Symptoms & Complications | CDC Middle East respiratory syndrome coronavirus disease in children Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi Arabia Transmission of MERScoronavirus in household contacts Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description The Role of Super-Spreaders in Infectious Disease Super-spreading events of MERS-CoV infection MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Development of Medical Countermeasures to Middle East Respiratory Syndrome Coronavirus WHO | Infection prevention and control (IPC) guidance summary. WHO MERS-COV Lab Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Performance and clinical validation of the RealStar MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA Real-time reverse transcription-PCR assay panel for Middle East respiratory syndrome coronavirus Development of dual taqman based one-step rrt-pcr assay panel for rapid and accurate diagnostic test of MERS-CoV: a novel human coronavirus, ahead of hajj pilgrimage Development and validation of a rapid immunochromatographic assay for detection of Middle East respiratory syndrome coronavirus antigen in dromedary camels An isothermal, label-free, and rapid one-step RNA amplification/detection assay for diagnosis of respiratory viral infections Comparison of ePlex respiratory pathogen panel with laboratory-developed real-time pcr assays for detection of respiratory pathogens Clinical validation of 3 commercial real-time reverse transcriptase polymerase chain reaction assays for the detection of Middle East respiratory syndrome coronavirus from upper respiratory tract specimens A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus A highly specific rapid antigen detection assay for on-site diagnosis of MERS Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity Lateral flow assays Development of monoclonal antibody and diagnostic test for middle east respiratory syndrome coronavirus using cell-free synthesized nucleocapsid antigen Middle East respiratory syndrome (MERS) coronavirus and dromedaries Identification of Mycoplasma suis antigens and development of a multiplex microbead immunoassay Serosurveillance of viral pathogens circulating in West Africa Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses A multiplex liquid-chip assay based on Luminex xMAP technology for simultaneous detection of six common respiratory viruses Surveillance and testing for middle east respiratory syndrome coronavirus Using Healthmap to analyse Middle East Respiratory Syndrome (MERS) data Progress in promoting data sharing in public health emergencies WHO | Influenza surveillance outputs Data sharing: make outbreak research open access The weapon potential of a microbe Biological agents: weapons of warfare and bioterrorism Explanation of the Nagoya Protocol on Access and Benefit Sharing and its implication for microbiology Global scientific research commons under the Nagoya Protocol:


id: cord-017615-zjr6csla
author: Hillman, John R.
title: Food Security in an Insecure Future
date: 2016-11-25
extension: .txt
mime: text/plain
words: 9985
sentence: 354
flesch: 32
cache: cache/cord-017615-zjr6csla.txt
txt: txt/cord-017615-zjr6csla.txt
summary:
  Poor countries are usually unable to defend themselves from terrorists, and groups of terrorists may receive covert support from other countries and agencies. Poor countries may form the battlefield for fighting between different groups of terrorists.


id: cord-312741-0au4nctt
author: Lin, Panpan
title: Coronavirus in human diseases: Mechanisms and advances in clinical treatment
date: 2020-10-01
extension: .txt
mime: text/plain
words: 14692
sentence: 507
flesch: 30
cache: cache/cord-312741-0au4nctt.txt
txt: txt/cord-312741-0au4nctt.txt
summary:
  The 9-kDa hydrophobic protein encoded at the 3' end of the porcine transmissible gastroenteritis coronavirus genome is membrane-associated Mouse hepatitis virus gene 5b protein is a new virion envelope protein Infectious bronchitis virus E protein is targeted to the Golgi complex and directs release of virus-like particles A comprehensive comparison of transmembrane domains reveals organelle-specific properties Subcellular location and topology of severe acute respiratory syndrome coronavirus envelope protein Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer Assembly of the coronavirus envelope: homotypic interactions between the M proteins SARS coronavirus E protein forms cation-selective ion channels Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors The transmembrane domain of the infectious bronchitis virus E protein is required for efficient virus release Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells Role of the coronavirus E viroporin protein transmembrane domain in virus assembly Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis Heterologous gene expression from transmissible gastroenteritis virus replicon particles Generation of a replication-competent, propagation-deficient virus vector based on the transmissible gastroenteritis coronavirus genome The small envelope protein E is not essential for murine coronavirus replication A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo Absence of E protein arrests transmissible gastroenteritis coronavirus maturation in the secretory pathway Characterization of severe acute respiratory syndrome coronavirus membrane protein Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus Genetic evidence for a structural interaction between the carboxy termini of the membrane and nucleocapsid proteins of mouse hepatitis virus The molecular biology of coronaviruses A structural analysis of M protein in coronavirus assembly and morphology Envelope glycoprotein interactions in coronavirus assembly Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system Coronaviruses: an overview of their replication and pathogenesis Nucleocapsidindependent assembly of coronavirus-like particles by co-expression of viral envelope protein genes Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction The missing link in coronavirus assembly. syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization Identification of in vivointeracting domains of the murine coronavirus nucleocapsid protein Glycogen synthase kinase-3 regulates the phosphorylation of severe acute respiratory syndrome coronavirus nucleocapsid protein and viral replication Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1 Theoretical aspects of virus capsid assembly Analysis of multimerization of the SARS coronavirus nucleocapsid protein Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein Envelope protein palmitoylations are crucial for murine coronavirus assembly The hydrophobic domain of infectious bronchitis virus E protein alters the host secretory pathway and is important for release of infectious virus The coronavirus E protein: assembly and beyond Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes The intracellular sites of early replication and budding of SARS-coronavirus Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer Glycan shield and epitope masking of a coronavirus spike protein observed by cryoelectron microscopy Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains A human homolog of angiotensin-converting enzyme.


id: cord-252883-1ub01j2x
author: Bleibtreu, A.
title: Focus on Middle East respiratory syndrome coronavirus (MERS-CoV)
date: 2019-11-11
extension: .txt
mime: text/plain
words: 6235
sentence: 274
flesch: 47
cache: cache/cord-252883-1ub01j2x.txt
txt: txt/cord-252883-1ub01j2x.txt
summary:
  WHO Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study New case of MERS-CoV identified in the United Kingdom Middle East respiratory syndrome coronavirus (MERS-CoV): prevention in travelers Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome Association of Higher MERS-CoV Virus Load with Severe Disease and Death, Saudi Arabia A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study Specific serology for emerging human coronaviruses by protein microarray Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Case characteristics among Middle East respiratory syndrome coronavirus outbreak and non-outbreak cases in Saudi Arabia from 2012 to 2015 Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea MERS-CoV outbreak in Jeddah-a link to health care facilities MERS outbreak in Korea: hospital-to-hospital transmission Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Middle East respiratory syndrome coronavirus infections in health care workers Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Hospital outbreak of middle east respiratory syndrome coronavirus Middle East respiratory syndrome A Comparative Study of Clinical Presentation and Risk Factors for Adverse Outcome in Patients Hospitalised with Acute Respiratory Disease Due to MERS Coronavirus or Other Causes Rapid risk assessment: Severe respiratory disease associated with Middle East respiratory syndrome coronavirus (MERS-CoV), 22nd update Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective study Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus infection: a short note on cases with renal failure problem State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity The impact of co-infection of influenza A virus on the severity of Middle East Respiratory Syndrome Coronavirus Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea IFN-(2a or IFN-(1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Viral RNA in blood as Indicator of Severe Outcome in Middle East Respiratory Syndrome Coronavirus Infection Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Prevention and treatment of respiratory viral infections: presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): a review Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind, single-dose-escalation study A review of treatment modalities for Middle East Respiratory Syndrome Corticosteroid Therapy for Critically Ill Patients with the Middle East Respiratory Syndrome Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Treatment With Lopinavir/Ritonavir or Interferon-(1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Alisporivir inhibits MERS-and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona-and picornaviruses Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice The chapters on the origin, emergence, structure, transmission mechanisms, prevention and diagnostic methods were mainly written MB, NH, and BV.BV produced the figures. Consensus document on the epidemiology of severe acute respiratory syndrome (SARS) Molecular evolution of human coronavirus genomes Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Severe respiratory illness caused by a novel coronavirus WHO | Background and summary of novel coronavirus infection-as of 21 Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological stud Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia MERS coronavirus neutralizing antibodies in camels Antibodies against MERS coronavirus in dromedary camels Risk factors for MERS coronavirus infection in dromedary camels in Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein A structural analysis of M protein in coronavirus assembly and morphology East respiratory syndrome coronavirus (MERS-CoV)-update.


id: cord-318181-xxc7vdnt
author: Ahmed, Anwar E.
date: 2018-03-14
extension: .txt
mime: text/plain
words: 4390
sentence: 150
flesch: 43
cache: cache/cord-318181-xxc7vdnt.txt
txt: txt/cord-318181-xxc7vdnt.txt
title:
  Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia

summary:
  Accuracy and cost comparison in medical testing using sequential testing strategies Reducing cost in sequential testing: a limit of indifference approach Believe the extreme (BE) strategy at the optimal point: what strategy will it become Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: a worldwide study The predictors of 3-and 30-day mortality in 660 MERS-CoV patients MERS-CoV diagnosis: an update The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: a retrospective study Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Laboratory testing for Middle East respiratory syndrome coronavirus (MERS-CoV) Case definition and surveillance guidance -updated Critically ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Evidence for camel-to-human transmission of MERS coronavirus Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis Clinical presentation and outcomes of Middle East Respiratory Syndrome in the Republic of Korea Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction Combining biomarkers to detect disease with application to prostate cancer Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate MERS-CoV outbreak in Jeddah-a link to health care facilities Combining diagnostic test results to increase accuracy MERS-CoV geography and ecology in the Middle East: analyses of reported camel exposures and a preliminary risk map Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia On the principles of believe the positive and believe the negative for diagnosis using two continuous tests Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data Emerging molecular markers of cancer Linear combinations of multiple diagnostic markers Comparative evaluation of three homogenization methods for isolating Middle East key: cord-318181-xxc7vdnt authors: Ahmed, Anwar E.; Al-Jahdali, Hamdan; Alshukairi, Abeer N.; Alaqeel, Mody; Siddiq, Salma S.; Alsaab, Hanan; Sakr, Ezzeldin A.; Alyahya, Hamed A.; Alandonisi, Munzir M.; Subedar, Alaa T.; Aloudah, Nouf M.; Baharoon, Salim; Alsalamah, Majid A.; Al Johani, Sameera; Alghamdi, Mohammed G. title: Early identification of pneumonia patients at increased risk of Middle East respiratory syndrome coronavirus infection in Saudi Arabia date: 2018-03-14 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2018.03.005 sha: doc_id: 318181 cord_uid: xxc7vdnt BACKGROUND: The rapid and accurate identification of individuals who are at high risk of Middle East respiratory syndrome coronavirus (MERS-CoV) infection remains a major challenge for the medical and scientific communities.


id: cord-323125-qtlevnbt
author: Al Hosani, Farida Ismail
date: 2019-02-01
extension: .txt
mime: text/plain
words: 3710
sentence: 153
flesch: 42
cache: cache/cord-323125-qtlevnbt.txt
txt: txt/cord-323125-qtlevnbt.txt
title:
  Serologic Follow-up of Middle East Respiratory Syndrome Coronavirus Cases and Contacts—Abu Dhabi, United Arab Emirates

summary:
  Data collected included demographics; residence/household description; exposure history to other MERS-CoV cases, healthcare settings, and animals; travel history; and medical history, including any long-term effects reported by case patients. Females comprised a higher proportion of case patients compared with household contacts (70.6% vs 53.2%), and case patients were older compared with household contacts (median, 42 years vs 31 years).


id: cord-311937-6hadssmh
author: Sherbini, Nahid
date: 2016-06-11
extension: .txt
mime: text/plain
words: 2860
sentence: 141
flesch: 49
cache: cache/cord-311937-6hadssmh.txt
txt: txt/cord-311937-6hadssmh.txt
title:
  Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: Demographic, clinical and survival data

summary:
  Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study Hospital outbreak of Middle East respiratory syndrome coronavirus Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 Family cluster of Middle East respiratory syndrome coronavirus infections Prevalence of diabetes mellitus in a Saudi community Severe acute respiratory syndrome and coronavirus Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection A major outbreak of severe acute respiratory syndrome in Hong Kong Clinical and laboratory features in the early stage of severe acute respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings This study did not receive funding. This study describes the clinical characteristics and outcome of MERS infected patients.


id: cord-275313-mfyff9ne
author: Modjarrad, Kayvon
title: Treatment strategies for Middle East respiratory syndrome coronavirus
date: 2016-01-01
extension: .txt
mime: text/plain
words: 3779
sentence: 128
flesch: 32
cache: cache/cord-275313-mfyff9ne.txt
txt: txt/cord-275313-mfyff9ne.txt
summary:
  Epidemiological update: Middle East respiratory syndrome coronavirus (MERS-CoV) From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia Dromedary camels and the transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) Serological evidence of MERS-CoV antibodies in dromedary camels (Camelus dromedaries) in Laikipia County Isolation of MERS coronavirus from a dromedary camel Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels MERS coronavirus in dromedary camel herd, Saudi Arabia Human-dromedary camel interactions and the risk of acquiring zoonotic Middle East respiratory syndrome coronavirus infection Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient Evidence for camel-to-human transmission of MERS coronavirus Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea Transmission among healthcare worker contacts with a Middle East respiratory syndrome patient in a single Korean centre Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Health-care associate transmission of Middle East Respiratory Syndrome Corona virus, MERS-CoV, in the Kingdom of Saudi Arabia Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach Estimation of MERS-coronavirus reproductive number and case fatality rate for the Spring 2014 Saudi Arabia outbreak: insights from publicly available data Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC Treatment with interferon-alpha2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques IFN-alpha2a or IFN-beta1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study Combination therapy with lopinavir/ritonavir, ribavirin and interferon-alpha for Middle East respiratory syndrome: a case report Ribavirin and interferon-alpha2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia Oral ribavirin for the treatment of noninfluenza respiratory viral infections: a systematic review Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis The use of convalescent plasma to treat emerging infectious diseases: focus on Ebola virus disease A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection Towards the prophylactic and therapeutic use of human neutralizing monoclonal antibodies for Middle East respiratory syndrome coronavirus (MERS-CoV) Evaluation of candidate vaccine approaches for MERS-CoV Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus Nucleotide prodrug GS-5734 is a broad-spectrum filovirus inhibitor that providescomplete therapeutic protection against the development of Ebola virus disease (EVD) in infected non-human primates ID Week BioCryst announces Nature publication demonstrating efficacy of BCX4430 in a non-human primate model of filovirus infection Structure of the fusion core and inhibition of fusion by a heptad repeat peptide derived from the S protein of Middle East respiratory syndrome coronavirus Design of potential RNAi (miRNA and siRNA) molecules for Middle East respiratory syndrome coronavirus (MERS-CoV) gene silencing by computational method Antiviral drugs specific for coronaviruses in preclinical development A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs Most recently, Middle East respiratory syndrome coronavirus (MERS-CoV) has emerged as a novel cause of severe acute respiratory illness after first being identified in a Saudi Arabian patient in 2012


id: cord-286631-3fmg3scx
author: Pormohammad, Ali
date: 2020-06-05
extension: .txt
mime: text/plain
words: 3676
sentence: 102
flesch: 28
cache: cache/cord-286631-3fmg3scx.txt
txt: txt/cord-286631-3fmg3scx.txt
title:
  Comparison of confirmed COVID‐19 with SARS and MERS cases ‐ Clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta‐analysis

summary:
  Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Association between severity of MERS-CoV infection and incubation period Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients Identified transmission dynamics of Middle East respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia Preliminary epidemiologic assessment of MERS-CoV outbreak in South Korea Clinical and epidemiologic characteristics of spreaders of Middle East respiratory syndrome coronavirus during the 2015 outbreak in Korea Transmission of MERScoronavirus in household contacts Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Hospital outbreaks of middle east respiratory syndrome Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Outbreaks of Middle East respiratory syndrome in two hospitals initiated by a single patient in Daejeon Covid-19: WHO declares pandemic because of alarming levels of spread, severity, and inaction Comparison of severe and non-severe COVID-19 pneumonia: review and meta-analysis. A novel coronavirus outbreak of global health concern Three Emerging Coronaviruses in Two Decades: the Story of SARS, MERS, and Now COVID-19 Severe acute respiratory syndrome (SARS): epidemiology and clinical features Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission A novel coronavirus from patients with pneumonia in China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-toperson transmission: a study of a family cluster Responding to Covid-19-A once-in-a-century pandemic? Rational use of personal protective equipment for coronavirus disease 2019 (COVID-19) Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins Potential COVID-2019 3C-like Protease Inhibitors Designed Using Generative Deep Learning Approaches Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement The development of a critical appraisal tool for use in systematic reviews: addressing questions of prevalence Statistical aspects of the analysis of data from retrospective studies Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Early epidemiological analysis of the 2019-nCoV outbreak based on a crowdsourced data Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-Infected pneumonia in Wuhan Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 2019 novel coronavirus infection in China Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia.


id: cord-317688-mr851682
author: Oh, Myoung-don
title: Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea
date: 2018-02-27
extension: .txt
mime: text/plain
words: 5576
sentence: 230
flesch: 45
cache: cache/cord-317688-mr851682.txt
txt: txt/cord-317688-mr851682.txt
summary:
  respiratory syndrome coronavirus KOR/KNIH/002_05_2015, isolated in South Korea Complete genome sequence of Middle East Respiratory syndrome coronavirus (MERS-CoV) from the first imported MERS-CoV case in China Isolation of Middle East respiratory syndrome coronavirus from a patient of the 2015 Korean outbreak Microevolution of outbreak-associated Middle East respiratory syndrome coronavirus, South Korea Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia The recent ancestry of Middle East respiratory syndrome coronavirus in Korea has been shaped by recombination Variations in spike glycoprotein gene of MERS-CoV Spread of mutant Middle East respiratory syndrome coronavirus with reduced affinity to human CD26 during the South Korean outbreak Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms Viral load kinetics of MERS coronavirus infection Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity Kinetics of serologic responses to MERS coronavirus infection in humans Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity MERS-CoV antibody responses 1 year after symptom onset, South Korea Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea Clinical implications of 5 cases of Middle East respiratory syndrome coronavirus infection in a South Korean outbreak Clinical progression and cytokine profiles of Middle East respiratory syndrome coronavirus infection Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Renal complications and their prognosis in Korean patients with Middle East respiratory syndrome-coronavirus from the central MERS-CoV designated hospital Neurological complications during treatment of Middle East respiratory syndrome Middle East respiratory syndrome-coronavirus infection: a case report of serial computed tomographic findings in a young male patient Differential cell count and CRP level in blood as predictors for Middle East respiratory syndrome coronavirus infection in acute febrile patients during nosocomial outbreak Guidelines for the laboratory diagnosis of Middle East respiratory syndrome coronavirus in Korea Korean Society for Laboratory Medicine practice guidelines for the molecular diagnosis of Middle East respiratory syndrome during an outbreak in Korea in 2015 Importance of specimen type and quality in diagnosing Middle East respiratory syndrome An appropriate lower respiratory tract specimen is essential for diagnosis of Middle East respiratory syndrome (MERS) Atypical presentations of MERS-CoV infection in immunocompromised hosts Antiviral treatment guidelines for Middle East respiratory syndrome Predictors of mortality in Middle East respiratory syndrome (MERS) Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Real-time characterization of risks of death associated with the Middle East respiratory syndrome (MERS) in the Republic of Korea Viral RNA in blood as indicator of severe outcome in Middle East respiratory syndrome coronavirus infection Association between severity of MERS-CoV infection and incubation period MERS-CoV infection in a pregnant woman in Korea Successful treatment of suspected organizing pneumonia in a patient with Middle East respiratory syndrome coronavirus infection: a case report Mental health status of people isolated due to Middle East respiratory syndrome Possible transfusionrelated acute lung injury following convalescent plasma transfusion in a patient with Middle East respiratory syndrome Middle East respiratory syndrome infection control and prevention guideline for healthcare facilities Middle East respiratory syndrome coronavirus transmission in dialysis unit and infection control interventions in Korea Middle East respiratory syndrome clinical practice guideline for hemodialysis facilities Stability of Middle East respiratory syndrome coronavirus (MERS-246 www CoV) under different environmental conditions Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea Environmental contamination and viral shedding in MERS patients Viral shedding and environmental cleaning in Middle East respiratory syndrome coronavirus infection Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS isolation wards Transmissibility of Middle East respiratory syndrome by the airborne route Nosocomial amplification of MERScoronavirus in South Korea Healthcare worker infected with Middle East Respiratory Syndrome during cardiopulmonary resuscitation in Korea Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity Seroprevalence of Middle East respiratory syndrome coronavirus among healthcare personnel caring for patients with middle east respiratory syndrome in South Korea Serologic evaluation of MERS screening strategy for healthcare personnel during a hospital-associated outbreak Middle East respiratory syndrome coronavirus transmission in dialysis unit and infection control interventions in Korea Management of asymptomatic persons who are RT-PCR positive for Middle East respiratory syndrome coronavirus (MERS-CoV): Interim guidance [Internet].


id: cord-284374-sqxlnk9e
author: Park, Jiyeon
date: 2020-01-15
extension: .txt
mime: text/plain
words: 4256
sentence: 169
flesch: 39
cache: cache/cord-284374-sqxlnk9e.txt
txt: txt/cord-284374-sqxlnk9e.txt
title:
  Infection Prevention Measures for Surgical Procedures during a Middle East Respiratory Syndrome Outbreak in a Tertiary Care Hospital in South Korea

summary:
  Moreover, there may be very few hospitals that are prepared to provide perioperative care for MERS patients. Almost all hospitals generally have positive-pressure operating rooms and they may experience an outbreak without facilities that are prepared for perioperative management of MERS patients, as our hospital did in 2015.


id: cord-318872-0e5zjaz1
author: Park, Ji-Eun
title: MERS transmission and risk factors: a systematic review
date: 2018-05-02
extension: .txt
mime: text/plain
words: 4161
sentence: 229
flesch: 54
cache: cache/cord-318872-0e5zjaz1.txt
txt: txt/cord-318872-0e5zjaz1.txt
summary:
  Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission Synthesizing data and models for the spread of MERS-CoV, 2013: key role of index cases and hospital transmission Identified transmission dynamics of Middle East respiratory syndrome coronavirus infection during an outbreak: implications of an overcrowded emergency department A pandemic risk assessment of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach High reproduction number of Middle East respiratory syndrome coronavirus in nosocomial outbreaks: mathematical modelling in Saudi Arabia and South Korea Accessed 10 Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea Fatality risks for nosocomial outbreaks of Middle East respiratory syndrome coronavirus in the Middle East and South Korea Middle East respiratory syndrome and medical students: letter from China Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data Clinical characteristics and outcome of ICU admitted MERS corona virus infected patients Risk factors for transmission of Middle East respiratory syndrome coronavirus infection during the 2015 outbreak in South Korea Estimating the risk of Middle East respiratory syndrome (MERS) death during the course of the outbreak in the Republic of Korea Multifacility outbreak of Middle East respiratory syndrome in Taif, Saudi Arabia Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia MERS-CoV outbreak in Jeddah-a link to health care facilities Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia Predictors of MERS-CoV infection: a large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia Taking stock of the first 133 MERS coronavirus cases globally-is the epidemic changing? Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans Outbreak of Middle East respiratory syndrome at tertiary care hospital Clinical and epidemiologic characteristics of spreaders of Middle East respiratory syndrome coronavirus during the 2015 outbreak in Korea Nosocomial amplification of MERS-coronavirus in South Korea Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses Association of higher MERS-CoV virus load with severe disease and death, Saudi Arabia Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia Spatial modelling of contribution of individual level risk factors for mortality from Middle East respiratory syndrome coronavirus in the Arabian Peninsula The predictors of 3-and 30-day mortality in 660 MERS-CoV patients Impact of comorbidity on fatality rate of patients with Middle East respiratory syndrome The epidemiology of Middle East respiratory syndrome coronavirus in the Kingdom of Saudi Arabia Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea Clinical presentation and outcomes of Middle East respiratory syndrome in the Republic of Korea High fatality rates and associated factors in two hospital outbreaks of MERS in Daejeon, the Republic of Korea Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia Spread of mutant Middle East respiratory syndrome coronavirus with reduced affinity to human CD26 during the South Korean outbreak Variations in spike glycoprotein gene of MERS-CoV Association between Australian Hajj Pilgrims' awareness of MERS-CoV, and their compliance with preventive measures and exposure to camels Factors influencing preventive behavior against Middle East respiratory syndrome-coronavirus among nursing students in South Korea Middle East respiratory syndrome-related knowledge, preventive behaviours and risk perception among nursing students during outbreak Probable transmission chains of Middle East respiratory syndrome coronavirus and the multiple generations of secondary infection in South Korea the role of super-spreaders in infectious disease Super-spreaders in infectious diseases Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis Authors' contributions JEP (corresponding author) designed the study, and conducted the data search and the analysis with JEP (1st author).


id: cord-345081-15s2i6f0
author: Al-Sehaibany, Fares S.
title: Middle East respiratory syndrome in children: Dental considerations
date: 2017-04-17
extension: .txt
mime: text/plain
words: 2655
sentence: 115
flesch: 36
cache: cache/cord-345081-15s2i6f0.txt
txt: txt/cord-345081-15s2i6f0.txt
summary:
  Update Middle East respiratory syndrome coronavirus (MERS-CoV) summary and literature update-as of Middle East respiratory syndrome (MERS): a new zoonotic viral pneumonia State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans MERS-CoV outbreak in Jeddah--a link to health care facilities A scenario-based evaluation of the Middle East respiratory syndrome coronavirus and the Hajj Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 Detection of the Middle East respiratory syndrome coronavirus genome in an air sample originating from a camel barn owned by an infected patient epidemiological findings from a retrospective investigation Middle East respiratory syndrome coronavirus infections in health care workers Middle East respiratory syndrome Middle East respiratory syndrome coronavirus in children Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises Aerosols and splatter in dentistry: a brief review of the literature and infection control implications Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study A family cluster of Middle East respiratory syndrome Coronavirus infections related to a likely unrecognized asymptomatic or mild case Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions Effects of Coronavirus infections in children Cultivation of bacteria and fungi Occupational Health problems in modern dentistry: a review Blood contamination of the aerosols produced by in vivo use of ultrasonic scalers Aerosol and splatter contamination from the operative site during ultrasonic scaling Characteristics of blood-containing aerosols generated by common powered dental instruments Measurement of airborne bacteria and endotoxin generated during dental cleaning Efficacy of three face masks in preventing inhalation of airborne contaminants in dental practice Infected health care workers and patient safety: a double standard Risk assessment of dental unit waterline contamination A survey of methods used to detect nosocomial legionellosis among participants in the National Nosocomial Infections Surveillance System Legionella contamination of dental-unit water Emerging and changing viral diseases in the new millennium Middle East respiratory syndrome coronavirus MERS-CoV: current knowledge gaps In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) respiratory syndrome coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection Middle East respiratory syndrome coronavirus (MERS-CoV).


id: cord-341795-zbqfs77n
author: Sikkema, R. S.
date: 2019-02-21
extension: .txt
mime: text/plain
words: 5008
sentence: 202
flesch: 51
cache: cache/cord-341795-zbqfs77n.txt
txt: txt/cord-341795-zbqfs77n.txt
title:
  Global status of Middle East respiratory syndrome coronavirus in dromedary camels: a systematic review

summary:
  The publications in this review show that the MERS-CoV mainly circulates in dromedary camel populations in the Middle East and part of Africa, and has been infecting dromedary camels in Africa for more than three decades. In total, 33 papers describe camel studies in the Middle East, 13 studies investigated camels from Africa and the remaining seven surveys were from Spain, Australia, Japan, Bangladesh and Pakistan (Table 1) .


id: cord-309621-6jj19xpr
author: Yu, Pin
date: 2017-02-24
extension: .txt
mime: text/plain
words: 4647
sentence: 174
flesch: 36
cache: cache/cord-309621-6jj19xpr.txt
txt: txt/cord-309621-6jj19xpr.txt
title:
  Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus

summary:
  Here, we comprehensively describe the histopathological features of the disease and the distribution of the MERS-CoV antigen and DDP4 in rhesus macaque and common marmoset models. key: cord-309621-6jj19xpr authors: Yu, Pin; Xu, Yanfeng; Deng, Wei; Bao, Linlin; Huang, Lan; Xu, Yuhuan; Yao, Yanfeng; Qin, Chuan title: Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus date: 2017-02-24 journal: PLoS One DOI: 10.1371/journal.pone.0172093 sha: doc_id: 309621 cord_uid: 6jj19xpr Middle East respiratory syndrome (MERS), which is caused by a newly discovered coronavirus (CoV), has recently emerged.


id: cord-287156-3plpi6i9
author: Lassandro, Giuseppe
title: Children in Coronaviruses’ Wonderland: What Clinicians Need to Know
date: 2020-07-01
extension: .txt
mime: text/plain
words: 8034
sentence: 366
flesch: 36
cache: cache/cord-287156-3plpi6i9.txt
txt: txt/cord-287156-3plpi6i9.txt
summary:
  Multisystem Inflammatory Syndrome in Children in COVID-19-associated immune thrombocytopenia Immune Thrombocytopenia (ITP) in a SARS-CoV-2 Positive Pediatric Patient Covid-19 and Children with Immune Thrombocytopenia: Emerging Issues Evans syndrome in a patient with COVID-19 COVID-19 infection associated with autoimmune hemolytic anemia Chest computed tomography in children with COVID-19 respiratory infection Clinical and CT imaging features of the COVID-19 pneumonia: Influenza Other Respir Viruses Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou Human Coronavirus Infections in Israel: Epidemiology, Clinical Symptoms and Summer Seasonality of HCoV-HKU1.


id: cord-316194-jnw8gr7e
author: Sifuentes, Monica
title: Chapter 61 Disorders of the Ear
date: 2005-12-31
extension: .txt
mime: text/plain
words: 7078
sentence: 359
flesch: 43
cache: cache/cord-316194-jnw8gr7e.txt
txt: txt/cord-316194-jnw8gr7e.txt
summary:
  Fever is not a sign of cholesteatoma and if present requires search for another intratemporal or intracranial suppurative complication of middle ear disease, especially when accompanied by otalgia. Congenital cholesteatoma is an asymptomatic keratotic white mass located behind an intact membrane in a patient with no significant history of recurrent middle ear disease or previous ear surgery.


id: cord-017731-xzfo5jjq
author: Todd, Ewen C. D.
title: Foodborne Disease in the Middle East
date: 2016-11-25
extension: .txt
mime: text/plain
words: 25397
sentence: 908
flesch: 48
cache: cache/cord-017731-xzfo5jjq.txt
txt: txt/cord-017731-xzfo5jjq.txt
summary:
  key: cord-017731-xzfo5jjq authors: Todd, Ewen C. D. title: Foodborne Disease in the Middle East date: 2016-11-25 journal: Water, Energy & Food Sustainability in the Middle East DOI: 10.1007/978-3-319-48920-9_17 sha: doc_id: 17731 cord_uid: xzfo5jjq Food safety is a concern worldwide and according to the World Health Organization, developing countries are probably more at risk of foodborne illness because many of these, including those in the Middle East, have limited disease surveillance and prevention and control strategies. Research has been focused on microbial contamination of locally-sold foodstuffs and manager and employee knowledge of food safety and hygienic conditions in food preparation establishments.


id: cord-022582-2e9i3m4b
author: Potsic, William P.
title: Otolaryngologic Disorders
date: 2012-03-21
extension: .txt
mime: text/plain
words: 16061
sentence: 895
flesch: 47
cache: cache/cord-022582-2e9i3m4b.txt
txt: txt/cord-022582-2e9i3m4b.txt
summary:
  Children who are born deaf and are younger than the age of 3 years, as well as children who have already developed communication skills, language, and speech before losing their hearing, derive the greatest benefit from cochlear implants. The sound has to traverse the ear canal, tympanic membrane, and middle ear.


