# bib

id: cord-336144-e7hvp9wy
author: Friedman, Kevin G.
title: Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children: A Call to Action
date: 2020-10-27
extension: .txt
mime: text/plain
words: 421
sentence: 11
flesch: 22
cache: cache/cord-336144-e7hvp9wy.txt
txt: txt/cord-336144-e7hvp9wy.txt
summary:
  Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-COVID-NET, 14 States Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children Multisystem inflammatory syndrome in children in New York state Multisystem inflammatory syndrome in U.S. children and adolescents COVID-19-associated multisystem inflammatory syndrome in children -United States Acute heart failure in multisystem inflammatory syndrome in children in the context of global SARS-CoV-2 pandemic Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19 Hyperinflammatory shock in children during COVID-19 pandemic Echocardiographic findings in pediatric multisystem inflammatory syndrome associated with COVID-19 in the United States KEY WORDS coronary artery abnormality, COVID-19, deformation, echocardiography, multisystem inflammatory syndrome in children (MIS-C) Cardiac Dysfunction in MIS-C This emerging syndrome has been defined by health organizations worldwide and named multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C) by the US Centers for Disease Control and Prevention (CDC).


id: cord-355636-mq7xb9d4
author: Booth, R.
title: Minimally invasive surgery in the COVID‐19 pandemic: An early single centre experience
date: 2020-08-21
extension: .txt
mime: text/plain
words: 739
sentence: 33
flesch: 48
cache: cache/cord-355636-mq7xb9d4.txt
txt: txt/cord-355636-mq7xb9d4.txt
summary:
  Patients should not be denied the clear advantages of laparoscopic surgery over open surgery during the current COVID-19 pandemic. Emergency surgery patient underwent PCR COVID-19 test prior to their procedure where feasible.


id: cord-313058-nrrl4kjc
author: Rivas, Magali Noval
date: 2020-10-16
extension: .txt
mime: text/plain
words: 1058
sentence: 28
flesch: 29
cache: cache/cord-313058-nrrl4kjc.txt
txt: txt/cord-313058-nrrl4kjc.txt
title:
  COVID-19 Associated Multisystem Inflammatory Syndrome in Children (MIS-C): a novel disease that mimics Toxic Shock Syndrome. The superantigen hypothesis

summary:
  It 99 will be interesting to determine whether these neurotoxin-like sequences in the SARS-100 CoV-2 S protein contribute to the neurological manifestations observed in children with 101 Why only a small fraction of SARS-CoV-2 infected children develop MIS-C 103 remains unclear. Given the structural similarities between SEB and the SARS-114 J o u r n a l P r e -p r o o f CoV-2 S protein SAg motif 5 , it is possible that antibodies within IVIG that neutralize 115 SEB cross-react with SARS-CoV-2 S, which may in part explain the beneficial response 116 of MIS-C cases to IVIG.


id: cord-301868-ehck72z2
author: Jhaveri, Simone
date: 2020-08-05
extension: .txt
mime: text/plain
words: 1209
sentence: 48
flesch: 40
cache: cache/cord-301868-ehck72z2.txt
txt: txt/cord-301868-ehck72z2.txt
title:
  Longitudinal Echocardiographic Assessment of Coronary Arteries and Left Ventricular Function Following Multisystem Inflammatory Syndrome in Children (MIS-C)

summary:
  Corticosteroids administered, % (n) 25% (1) 12.5% (1) 20% (3) Tocilizumab administered, % (n) 100% (4) 62.5% (5) 60% (9) Anakinra administered, % (n) 25% (1) 0% (0) 13.3% (2) Therapeutic anticoagulation % (n) 100 (4)% 100% (8) 100% (15) Remdesivir administered, % (n) 25% (1) 12.5% (1) 20% (3) Plasma therapy administered, % (n) 0% 0% (0) 6.7% (1) ASA during admission, % (n) 50% (2) 0% (0) 13.3% (2) Site of coronary artery involvement (individual patient)1. Eight patients (53%) presented with LV dysfunction (EF <55%) ranging from mild to severe (n=2 with EF 50-54%; n=4 with EF 40-49% and n=2 with EF <35%).


id: cord-271186-82q22u6i
author: Picichè, Marco
title: Cardiac Involvment in SARS-CoV-2-Associated Inflammatory Syndromes
date: 2020-08-05
extension: .txt
mime: text/plain
words: 1219
sentence: 50
flesch: 35
cache: cache/cord-271186-82q22u6i.txt
txt: txt/cord-271186-82q22u6i.txt
summary:
  While Europe carefully reopened its borders to travelers after the incidence of new COVID-19 cases dramatically decreased during a lockdown, the virus continues to run rampant in the United States and Latin America. However, notwithstanding the existence of considerable observational data on the use of ECMO for influenza A (H1N1) and Middle East Respiratory Syndrome (MERS) coronavirus-related ARDS, the real utility of ECMO in adult COVID-19 patients with respiratory failure is uncertain and remains under investigation [15] .


id: cord-035239-5zdjxtm7
author: Makvandi, Shayan
date: 2020-10-10
extension: .txt
mime: text/plain
words: 1450
sentence: 62
flesch: 38
cache: cache/cord-035239-5zdjxtm7.txt
txt: txt/cord-035239-5zdjxtm7.txt
title:
  A Rare Presentation of Multi-System Inflammatory Disease in Children Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

summary:
  Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 Characteristics, cardiac involvement, and outcomes of multisystem inflammatory disease of childhood (MIS-C) associated with SARS-CoV-2 infection Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City Multisystem Inflammatory Syndrome in Children during the COVID-19 pandemic: a case series Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort Hyperinflammatory shock in children during COVID-19 pandemic COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; a Western New York approach Cardiac MRI of children with multisystem inflammatory syndrome (MIS-C) associated with COVID-19: case series Multisystem inflammatory syndrome in children in New York key: cord-035239-5zdjxtm7 authors: Makvandi, Shayan; Alibrahim, Omar; Abdul-Aziz, Rabheh; Abdul-Fattah Sallam, Mohammad; McGreevy, Megan title: A Rare Presentation of Multi-System Inflammatory Disease in Children Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) date: 2020-10-10 journal: nan DOI: 10.7759/cureus.10892 sha: doc_id: 35239 cord_uid: 5zdjxtm7 Management of multi-system inflammatory disease in children (MIS-C) remains a challenge due to the evolving nature of the coronavirus disease 2019 (COVID-19) pandemic.


id: cord-322435-c88tkbnz
author: Rekhtman, Sergey
date: 2020-10-24
extension: .txt
mime: text/plain
words: 1491
sentence: 65
flesch: 45
cache: cache/cord-322435-c88tkbnz.txt
txt: txt/cord-322435-c88tkbnz.txt
title:
  Mucocutaneous Disease and Related Clinical Characteristics in Hospitalized Children and Adolescents with COVID-19 and MIS-C

summary:
  Results In COVID-19 patients, 4/12 (33%) had rash and/or mucositis, including erythema, morbilliform pattern, and lip mucositis. COVID-19 patients with rash had less frequent respiratory symptoms, PICU admission, and invasive ventilation, as well as shorter stay (vs COVID-19 without rash).


id: cord-308046-y9kui730
author: Naka, Fludiona
title: A Dermatologic Perspective on Multisystem Inflammatory Syndrome in Children()()
date: 2020-09-23
extension: .txt
mime: text/plain
words: 1574
sentence: 61
flesch: 39
cache: cache/cord-308046-y9kui730.txt
txt: txt/cord-308046-y9kui730.txt
summary:
  Table 4 summarizes the top mucocutaneous manifestations of children with MIS-C. 10-12, 14-21, 23-24 The skin findings associated with MIS-C tend to be more common in younger children and decrease with age. Case definition for MIS-C Guidance: Pediatric multisystem inflammatory syndrome temporally associated with COVID-19 Hyperinflammatory shock in children during COVID-19 pandemic Childhood Multisystem Inflammatory Syndrome -A New Challenge in the Pandemic Pediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Pediatric Hospital Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Multi-institutional Study from New York City Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic Multisystem Inflammatory Syndrome in Children (MIS-C) Related to COVID-19: A New York City Experience Kawasaki-like multisystem inflammatory syndrome in children during the COVID-19 pandemic in Paris, France: prospective observational study Multisystem inflammatory syndrome in children in New York State Pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicenter cohort Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents Multisystem inflammatory syndrome in U.S. children and adolescents Clinical characteristics of coronavirus disease 2019 in China Classification of the cutaneous manifestations of COVID -19: a rapid prospective nationwide consensus study in Spain with 375 cases Varicella-like exanthem associated with COVID-19 in an 8-year-old girl: A diagnostic clue? Reply to COVID-19 can present with a rash and be mistaken for Dengue:


id: cord-317822-e4uhop4w
author: Bahrami, Ahmad
date: 2020-07-08
extension: .txt
mime: text/plain
words: 1865
sentence: 83
flesch: 46
cache: cache/cord-317822-e4uhop4w.txt
txt: txt/cord-317822-e4uhop4w.txt
title:
  Hyperinflammatory shock related to COVID‐19 in a patient presenting with multisystem inflammatory syndrome in children: First case from Iran

summary:
  Royal College of Paediatrics and Child Health COVID-19 and Kawasaki disease: Novel virus and novel case An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: An observational cohort study Concurrent respiratory viruses and Kawasaki disease Complex immune dysregulation in COVID-19 patients with severe respiratory failure We would like to thank both our patient and her family for letting us share their experience. According to previous studies, the most common viruses detected in KD patients were rhinovirus and enterovirus.


id: cord-354093-zdhfyotl
author: Kohli, Utkarsh
title: Cardiac Involvement in Children With COVID-19
date: 2020-08-07
extension: .txt
mime: text/plain
words: 1887
sentence: 64
flesch: 27
cache: cache/cord-354093-zdhfyotl.txt
txt: txt/cord-354093-zdhfyotl.txt
summary:
  This review focuses on cardiac involvement during COVID-19 infection and the multisystem inflammatory syndrome in children (MIS-C) Cardiac involvement during COVID-19 is not common in children who require pediatric intensive care unit (PICU) admission; use of inotropes was reported in 12 (25%)


id: cord-351126-d6lfktf9
author: Kofman, Aaron D.
date: 2020-09-29
extension: .txt
mime: text/plain
words: 1935
sentence: 82
flesch: 41
cache: cache/cord-351126-d6lfktf9.txt
txt: txt/cord-351126-d6lfktf9.txt
title:
  A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report

summary:
  key: cord-351126-d6lfktf9 authors: Kofman, Aaron D.; Sizemore, Emma K.; Detelich, Joshua F.; Albrecht, Benjamin; Piantadosi, Anne L. title: A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report date: 2020-09-29 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05439-z sha: doc_id: 351126 cord_uid: d6lfktf9 BACKGROUND: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. Authors' contributions AK and AP analyzed and interpreted the patient data regarding clinical infectious diseases presentation.


id: cord-344683-lr1xr2um
author: Cabler, Stephanie
title: A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes
date: 2020-09-30
extension: .txt
mime: text/plain
words: 2086
sentence: 84
flesch: 38
cache: cache/cord-344683-lr1xr2um.txt
txt: txt/cord-344683-lr1xr2um.txt
summary:
  HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis Clinical progression of patients with COVID-19 in Shanghai Clinical and immunological features of severe and moderate coronavirus disease 2019 Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19 Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study Pediatric Critical Care and COVID19 Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors COVID-19-Associated Multisystem Inflammatory Syndrome in Children -United States Pediatric SARS-CoV-2: Large cohorts of pediatric patients with severe COVID-19 and associated laboratory findings are uncommon.


id: cord-294729-c9f0iokr
author: Orr, William B.
date: 2020-10-01
extension: .txt
mime: text/plain
words: 2627
sentence: 84
flesch: 23
cache: cache/cord-294729-c9f0iokr.txt
txt: txt/cord-294729-c9f0iokr.txt
title:
  Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed

summary:
  Our representative case of a patient with coronavirus disease-19-associated multisystem inflammatory syndrome in children without robust hyperinflammation and a delayed finding of coronary artery dilatation compared with reported case series highlights the need for further mechanistic understanding of coronavirus disease-19 disease and subsequent multisystem inflammatory syndrome in children or Kawasaki disease development. Conclusion: Our representative case of a patient with coronavirus disease-19-associated multisystem inflammatory syndrome in children without robust hyperinflammation and a delayed finding of coronary artery dilatation compared with reported case series highlights the need for further mechanistic understanding of coronavirus disease-19 disease and subsequent multisystem inflammatory syndrome in children or Kawasaki disease development.


id: cord-351634-x1aw6gv2
author: Brumfiel, Caitlin M.
title: Dermatologic manifestations of COVID-19-associated multisystem inflammatory syndrome in children
date: 2020-11-01
extension: .txt
mime: text/plain
words: 2550
sentence: 95
flesch: 28
cache: cache/cord-351634-x1aw6gv2.txt
txt: txt/cord-351634-x1aw6gv2.txt
summary:
  A Systematic Review Hospitalization Rates and Characteristics of Children Aged <18 Years Hospitalized with Laboratory-Confirmed COVID-19 -COVID-NET, 14 States Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 Centers for Disease Control and Prevention Health Alert Network (HAN) COVID-19-Associated Multisystem Inflammatory Syndrome in Children -United States Multisystem Inflammatory Syndrome in U.S. Children and Adolescents Multisystem Inflammatory Syndrome in Children in New York State Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study Demographic Trends of COVID-19 cases and deaths in the US reported to CDC Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 Defining Association between COVID-19 and the Multisystem Inflammatory Syndrome in Children through the Pandemic Pediatric Coronavirus Disease-2019-Associated Multisystem Inflammatory Syndrome COVID-19 and Kawasaki disease in children Clinical Characteristics of Coronavirus Disease 2019 in China Cutaneous manifestations in COVID-19: a first perspective Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infection Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: 3 Beginning in late April 2020, multisystem inflammatory syndrome in children (MIS-C) became an increasingly recognized hyperinflammatory phenotype in pediatric patients with evidence of COVID-19 infection.


id: cord-271662-h281jgcb
author: Dove, M.
title: Multisystem Inflammatory Syndrome in Children: Survey of Early Hospital Evaluation and Management
date: 2020-08-01
extension: .txt
mime: text/plain
words: 3239
sentence: 140
flesch: 48
cache: cache/cord-271662-h281jgcb.txt
txt: txt/cord-271662-h281jgcb.txt
summary:
  We summarized key findings and compared results from centers that had treated >5 patients vs. those that had treated <5 patients. About half (21/40) of centers required only 1 day of fever for MIS-C to be considered.


id: cord-293715-lipme817
author: Hutchison, Lisa
date: 2020-06-30
extension: .txt
mime: text/plain
words: 3237
sentence: 129
flesch: 37
cache: cache/cord-293715-lipme817.txt
txt: txt/cord-293715-lipme817.txt
title:
  Neuropsychiatric Symptoms in an Adolescent Boy with Multisystem Inflammatory Syndrome in Children (MIS-C)

summary:
  Across case series, the number of patients with MIS-C who had a positive SARS-CoV-2 PCR ranged from 13-69% while the number of patients with positive serology ranged from 53-97% (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) . First, delirium and other neuropsychiatric symptoms ranging from encephalitis to focal neuropathies, changes in taste and smell, and acute brainstem dysfunction have been described in patients with COVID-19 (20) (21) .


id: cord-350401-suefuurq
author: Lima-Setta, Fernanda
date: 2020-11-09
extension: .txt
mime: text/plain
words: 3946
sentence: 138
flesch: 41
cache: cache/cord-350401-suefuurq.txt
txt: txt/cord-350401-suefuurq.txt
title:
  Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study()()()

summary:
  Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection Pediatric critical care and COVID-19 Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome Multisystem inflammatory syndrome associated with coronavirus disease in children: a multi-centered study in Belém Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development Considering how biological sex impacts immune responses and COVID-19 outcomes COVID-19: consider cytokine storm syndromes and immunosuppression Human leukocyte antigen susceptibility map for severe acute respiratory syndrome coronavirus 2 Genomic diversity of severe acute respiratory syndrome-coronavirus 2 in patients with coronavirus disease 2019 Use of biomarkers in pediatric sepsis: literature review COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome? [23] IL-6 appears to play an important role in severe adult patients with COVID-19, in whom the compassionate use of tocilizumab for pharmacologic inhibition of IL-6 has been described.


id: cord-030192-ebsh62ll
author: Winant, Abbey J.
date: 2020-07-30
extension: .txt
mime: text/plain
words: 4308
sentence: 158
flesch: 28
cache: cache/cord-030192-ebsh62ll.txt
txt: txt/cord-030192-ebsh62ll.txt
title:
  Thoracic Imaging Findings of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19: What Radiologists Need to Know Now

summary:
  4, 5, 13, 16 Given the current lack of available information related to the thoracic imaging findings of pediatric MIS-C associated with COVID-19 infection, the purpose of this article is to provide an up-to-I n p r e s s date review of the clinical and imaging features of pediatric MIS-C associated with COVID-19 infection, compared with acute pediatric COVID-19 infection, with an emphasis on thoracic imaging findings. In addition, while the incidence of Kawasaki disease is highest in Asia, strikingly, there have been no reported cases of MIS-C in Asia, despite being an early hotspot of COVID-19 infection, with some of the earliest published series on acute pediatric COVID-19 infection emerging from China.


id: cord-281948-xv7vuypd
author: Hoang, Ansel
title: COVID-19 in 7780 pediatric patients: A systematic review
date: 2020-06-26
extension: .txt
mime: text/plain
words: 4070
sentence: 191
flesch: 43
cache: cache/cord-281948-xv7vuypd.txt
txt: txt/cord-281948-xv7vuypd.txt
summary:
  Compared to that review and other COVID-19 pediatric systematic reviews, [18À21] this manuscript has several key advantages: (1) we summarize 131 studies that includes 7780 children from 26 different countries, (2) this report synthesizes underlying pediatric medical conditions and delineates bacterial and viral coinfections, (3) we quantitatively describe clinical symptoms and imaging findings, (4) herein, we conglomerate the mean and standard deviation of frequently used laboratory analytes in COVID-19 positive children, (5) our report presents antiviral therapies by specific agents, and (6) our systematic review offers a preliminary comparison of patients with/without MIS-C. Although SARS-CoV-2 infection was first identified in China, the United States has now amassed the highest number of confirmed cases [18] . Statistical analyses between COVID-19 pediatric patients with/ without MIS-C was conducted on STATA v¢13.


id: cord-315508-8bcpxo02
author: Sperotto, Francesca
date: 2020-08-15
extension: .txt
mime: text/plain
words: 4412
sentence: 214
flesch: 40
cache: cache/cord-315508-8bcpxo02.txt
txt: txt/cord-315508-8bcpxo02.txt
title:
  Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach

summary:
  compared patients meeting the MIS-C definition with classical KD or KDSS patients [20] , reporting that patients with MIS-C were generally older, had higher white blood cell count, neutrophil count, CRP, fibrinogen levels and higher troponin, as well as more profound lymphopenia, anemia, and lower platelet counts. Compared with KD patients without any signs of shock, KDSS patients were more frequently female, had a larger proportion of bands, higher CRP, and lower hemoglobin and platelet counts [42] .


id: cord-278672-pxzsntfg
author: Milenkovic, Aleksandar
date: 2020-06-16
extension: .txt
mime: text/plain
words: 4611
sentence: 191
flesch: 41
cache: cache/cord-278672-pxzsntfg.txt
txt: txt/cord-278672-pxzsntfg.txt
title:
  Extensions and Adaptations of Existing Medical Information System in Order to Reduce Social Contacts During COVID-19 Pandemic

summary:
  Before the beginning of COVID-19 pandemic MIS MEDIS.NET did not have specifically developed software functionalities (modules, subsystems) which would help healthcare workers and patients to combat seasonal and exceptional pandemics. The therapy of chronic patients has been prolonged for 6 months via an electronic prescription.


id: cord-339709-49q2xxkw
author: sermet, i.
date: 2020-06-30
extension: .txt
mime: text/plain
words: 4756
sentence: 197
flesch: 49
cache: cache/cord-339709-49q2xxkw.txt
txt: txt/cord-339709-49q2xxkw.txt
title:
  Prior infection by seasonal coronaviruses does not prevent SARS-CoV-2 infection and associated Multisystem Inflammatory Syndrome in children

summary:
  A majority of MIS children (25/36) were SARS-CoV-2 seropositive, of which all tested (n=15) had neutralizing antibodies. Coronavirus Disease 2019 in Children -United States SARS-CoV-2 Infection in Children Epidemiology of COVID-19 Among Children in China Characteristics of and Important Lessons From the Coronavirus Disease 389 2019 (COVID-19) Outbreak in China:


id: cord-314662-nem6dw34
author: Nakra, Natasha A.
date: 2020-07-01
extension: .txt
mime: text/plain
words: 5549
sentence: 219
flesch: 33
cache: cache/cord-314662-nem6dw34.txt
txt: txt/cord-314662-nem6dw34.txt
title:
  Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management

summary:
  The epidemiology and pathogenesis of Kawasaki disease Association between a novel human coronavirus and Kawasaki disease The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease Recognition of a Kawasaki disease shock syndrome Kawasaki disease: An unexpected etiology of shock and multiple organ dysfunction syndrome Kawasaki disease shock syndrome: Unique and severe subtype of Kawasaki disease Structure-based preliminary analysis of immunity and virulence of SARS coronavirus Toxic shock syndrome in children: Epidemiology, pathogenesis, and management Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: A systematic review and meta-analysis Early differentiation of Kawasaki disease shock syndrome and toxic shock syndrome in a pediatric intensive care unit On the alert for cytokine storm: Immunopathology in COVID-19 Macrophage activation syndrome in the era of biologic therapy DNA viremia is associated with hyperferritinemia in pediatric sepsis Hemophagocytic lymphohistiocytosis and infections: An update Macrophage activation syndrome in the acute phase of Kawasaki disease Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis Calm in the midst of cytokine storm: A collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome Marked hyperferritinemia does not predict for HLH in the adult population HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A European league against rheumatism/American college of rheumatology/paediatric rheumatology international trials organisation collaborative initiative Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease-The SHARE initiative Prediction of intravenous immunoglobulin unresponsiveness in patients with Kawasaki disease Intravenous immunoglobulin plus corticosteroid to prevent coronary artery abnormalities in Kawasaki disease: A meta-analysis Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): A randomised, open-label, blinded-endpoints trial Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm Coronary-artery aneurysm in tocilizumab-treated children with Kawasaki's disease Long-term efficacy and safety of tocilizumab in giant cell arteritis and large vessel vasculitis Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: An increased risk for candidemia? As compared to other children with KD, patients with Kawasaki disease shock syndrome (KDSS) have higher band counts, lower platelet counts, lower hemoglobin levels, and higher C-reactive protein levels


id: cord-274834-24v2b509
author: Lima, Rosiane
date: 2020-09-11
extension: .txt
mime: text/plain
words: 5596
sentence: 220
flesch: 36
cache: cache/cord-274834-24v2b509.txt
txt: txt/cord-274834-24v2b509.txt
title:
  Establishment of a pediatric COVID-19 biorepository: unique considerations and opportunities for studying the impact of the COVID-19 pandemic on children

summary:
  The methodology described here, details the importance of establishing collaborations between the clinical and research teams to harmonize protocols for patient recruitment and sample collection, processing and storage. Cornerstones of the biorepository included open dialogue between research and clinical team members, a sensitivity to procedures required for specimen collection in children, and clear documentation of study participation and sample collection.


id: cord-336049-n3swuykg
author: Ahmed, Mubbasheer
title: Multisystem inflammatory syndrome in children: A systematic review
date: 2020-09-04
extension: .txt
mime: text/plain
words: 5689
sentence: 259
flesch: 41
cache: cache/cord-336049-n3swuykg.txt
txt: txt/cord-336049-n3swuykg.txt
summary:
  key: cord-336049-n3swuykg authors: Ahmed, Mubbasheer; Advani, Shailesh; Moreira, Axel; Zoretic, Sarah; Martinez, John; Chorath, Kevin; Acosta, Sebastian; Naqvi, Rija; Burmeister-Morton, Finn; Burmeister, Fiona; Tarriela, Aina; Petershack, Matthew; Evans, Mary; Hoang, Ansel; Rajasekaran, Karthik; Ahuja, Sunil; Moreira, Alvaro title: Multisystem inflammatory syndrome in children: A systematic review date: 2020-09-04 journal: EClinicalMedicine DOI: 10.1016/j.eclinm.2020.100527 sha: doc_id: 336049 cord_uid: n3swuykg BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), also known as pediatric inflammatory multisystem syndrome, is a new dangerous childhood disease that is temporally associated with coronavirus disease 2019 (COVID-19). Circulation A case of pediatric multisystem inflammatory syndrome temporally associated with COVID-19 in South Dakota New onset severe right ventricular failure associated with COVID-19 in a young infant without previous heart disease Septic shock presentation in adolescents with COVID-19 Hyperinflammatory shock related to COVID-19 in a patient presenting with multisystem inflammatory syndrome in children: first case from Iran Pediatric inflammatory multisystem syndrome with central nervous system involvement and hypocomplementemia following SARS-COV-2 infection Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children SARS-CoV-2-induced Kawasaki-like hyperinflammatory syndrome: a novel COVID phenotype in children Case report: systemic inflammatory response and fast recovery in a pediatric patient with COVID-19 Cardiac MRI of Children with Multisystem Inflammatory Syndrome (MIS-C) Associated with COVID-19: case Series [published online ahead of print Immune-inflammatory parameters in COVID-19 cases: a systematic review and meta-analysis Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19 Clinical value of immune-inflammatory parameters to assess the severity of coronavirus disease 2019 Procalcitonin as a marker of the systemic inflammatory response to infection Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis Interleukin-6 as prognosticator in patients with COVID-19 Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19) High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa A nomogram to predict the risk of unfavourable outcome in COVID-19: a retrospective cohort of 279 hospitalized patients in Paris area Changes in clinical and laboratory features of Kawasaki disease noted over time in Daejeon The riddle of Kawasaki disease Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort Descriptive epidemiology of Kawasaki disease in Japan Pediatric crohn disease and multisystem inflammatory syndrome in children (MIS-C) and COVID-19 treated with infliximab Spectrum of imaging findings on chest radiographs, US, CT, and MRI images in multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 Horizontal transmission of severe acute respiratory syndrome coronavirus 2 to a premature infant: multiple organ injury and association with markers of inflammation Paediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2 (PIMS-TS): cardiac features, management and short-term outcomes at a UK tertiary paediatric hospital SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study Cardiac MRI of children with multisystem inflammatory syndrome (MIS-C) associated with COVID-19: case series Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2 infection: a multi-institutional study from New York City


id: cord-354608-1me3nopu
author: Rabinowicz, Shira
title: COVID-19 in the Pediatric Population—Review and Current Evidence
date: 2020-09-19
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words: 5429
sentence: 238
flesch: 38
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summary:
  Epidemiology of COVID-19 among children in China Coronavirus disease 2019 in children -United States Department of Health and Human Services SARS-COV-2 infection in children and newborns : a systematic review Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor SARS-CoV-2 detection, viral load and infectivity over the course of an infection Age-related differences in nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) levels in patients with mild to moderate coronavirus disease American Medical Association The immune system of children: the key to understanding SARS-CoV-2 susceptibility? COVID-19 pathophysiology: a review Pathophysiology of COVID-19: Why children fare better than adults? Daycare attendance and respiratory tract infections: a prospective birth cohort study The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases ( COVID-19 ) -China Coronavirus disease 2019 (COVID-19) in Italy Children with COVID-19 in Pediatric Emergency Departments in Italy SARS-CoV-2 Infection in children Articles COVID-19 in children and adolescents in Europe : a multinational , multicentre cohort study COVID-19 in children and the dynamics of infection in families Coinfection and other clinical characteristics of COVID-19 in children SARS-CoV-2 transmission and infection among attendees of an overnight camp -Georgia A large COVID-19 outbreak in a high school 10 days after schools' reopening, Israel Plan for school reopening | IIEP-UNESCO Asymptomatic transmission and the infection fatality risk for COVID-19: implications for school reopening Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China COVID-19: consider cytokine storm syndromes and immunosuppression Anosmia and ageusia: common findings in COVID-19 patients Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19 -COVID-NET, 14 States Characteristics and outcomes of children with coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian Pediatric Intensive Care Units Clinical characteristics and outcomes of hospitalized and critically ill children and adolescents with coronavirus disease 2019 at a tertiary care medical center Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Care of newborns born to mothers with COVID-19 infection; a review of existing evidence Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan Maternal and perinatal outcomes with COVID-19: a systematic review of 108 pregnancies Neonatal resuscitation and postresuscitation care of infants born to mothers with suspected or confirmed SARS-CoV-2 infection Transplacental transmission of SARS-CoV-2 infection Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 Multisystem inflammatory syndrome with features of atypical Kawasaki disease during COVID-19 pandemic Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic Hyperinflammatory shock in children during COVID-19 pandemic COVID-19-associated multisystem inflammatory syndrome in children -United States Multisystem inflammatory syndrome in U.S. children and adolescents Multi-system inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection: review of clinical presentation, hypothetical pathogenesis, and proposed management COVID-19 and multisystem inflammatory syndrome in children and adolescents Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 and hyperinflammation in COVID-19. Microorganisms Supportive treatment with tocilizumab for COVID-19: a systematic review Managing childhood allergies and immunodeficiencies during respiratory virus epidemics -The 2020 COVID-19 pandemic : a statement from the EAACI-section on pediatrics Considerations on biologicals for patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement Characteristics and outcomes of Coronavirus Infection in Children: The role of viral factors and an immunocompromised state Coronaviruses and immunosuppressed patients: the facts during the third epidemic COVID-19 in immunocompromised hosts: what we know so far Reluctance to seek pediatric care during the COVID-19 pandemic and the risks of delayed diagnosis Delayed emergency surgical presentation: impact of corona virus disease (COVID-19) on non-COVID patients Gathering evidence on the decreased emergency room visits during the coronavirus disease 19 pandemic Routine vaccination during covid-19 pandemic response Masked paediatricians during the COVID -19 pandemic and communication with children Pandemic school closures: risks and opportunities ADHD management during the COVID-19 pandemic: guidance from the European ADHD Guidelines Group Acute stress, behavioural symptoms and mood states among school-age children with attention-deficit/hyperactive disorder during the COVID-19 outbreak Starting ADHD medications during the COVID-19 pandemic: recommendations from the European ADHD Guidelines Group Challenges and burden of the Coronavirus 2019 (COVID-19) pandemic for child and adolescent mental health: a narrative review to highlight clinical and research needs in the acute phase and the long return to normality Impact of COVID-19 and lockdown on mental health of children and adolescents: a narrative review with recommendations An investigation of mental health status of children and adolescents in china during the outbreak of COVID-19 Mental health status among children in home confinement during the coronavirus disease Child protection in the time of <scp>COVID</ scp> -19.


id: cord-293367-0fe62h2f
author: Henderson, Lauren A.
date: 2020-07-23
extension: .txt
mime: text/plain
words: 6235
sentence: 215
flesch: 30
cache: cache/cord-293367-0fe62h2f.txt
txt: txt/cord-293367-0fe62h2f.txt
title:
  American College of Rheumatology Clinical Guidance for Pediatric Patients with Multisystem Inflammatory Syndrome in Children (MIS‐C) Associated with SARS‐CoV‐2 and Hyperinflammation in COVID‐19. Version 1

summary:
  All rights reserved RECOVERY trial) report that low to moderate dose dexamethasone significantly reduced mortality in COVID-19 patients requiring mechanical ventilation; but was reported after voting had occurred.(90, 91) Based on these studies that suggest that patients with severe COVID-19 pneumonia may benefit from immunomodulation with glucocorticoids, the Task Force achieved moderate consensus that glucocorticoid treatment could be considered in pediatric patients with severe COVID-19 and signs of hyperinflammation. The first webinar was used to confirm the target audience for the guidance, which focuses on clinicians in North America managing pediatric patients with inflammatory syndromes related to recent or concurrent infections with SARS-CoV-2.


id: cord-293259-o51fnvuw
author: Sinaei, Reza
title: Why COVID-19 is less frequent and severe in children: a narrative review
date: 2020-09-25
extension: .txt
mime: text/plain
words: 7048
sentence: 303
flesch: 41
cache: cache/cord-293259-o51fnvuw.txt
txt: txt/cord-293259-o51fnvuw.txt
summary:
  Genomic contributions and opportunities Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome Interleukin-1 receptor antagonist is associated with pediatric acute respiratory distress syndrome and worse outcomes in children with acute respiratory failure Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by exome-seq Association of polymorphisms in genes of factors involved in regulation of splicing of cystic fibrosis transmembrane conductance regulator mRNA with acute respiratory distress syndrome in children with pneumonia Genetic gateways to COVID-19 infection: implications for risk, severity, and outcomes Differential expression of COVID-19-related genes in European Americans and African Americans Analysis of genetic host response risk factors in severe COVID-19 patients Down-regulated gene expression spectrum and immune responses changed during the disease progression in COVID-19 patients Genomewide association study of severe Covid-19 with respiratory failure The authors thank the staff and participants of this In a retrospective review of all COVID-19 patients treated at Wuhan union hospital until March 20, 2020, Mi et al. evaluated the correlation between prior exposures to MP and better clinical response in COVID-19 patients.


