item: #1 of 104
id: cord-000249-hkc4vbmj
author: Schughart, Klaus
title: SYSGENET: a meeting report from a new European network for systems genetics
date: 2010-07-11
words: 2531
flesch: 35
summary: A new set of BXD recombinant inbred lines from advanced intercross populations in mice The mouse as a model for human biology: a resource guide for complex trait analysis The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics A role for stroma-derived annexin A1 as mediator in the control of genetic susceptibility to T-cell lymphoblastic malignancies through prostaglandin E2 secretion Allelic skewing of DNA methylation is widespread across the genome Perchance to dream: solving the mystery of sleep through genetic analysis Host genetic background strongly influences the response to influenza a virus infections Beyond standardization: dynamic software infrastructures for systems biology XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice Genetic determinants in hepatic fibrosis: from experimental models to fibrogenic gene signatures in humans Bao L, Wei L, Peirce JL, Homayouni R, Li H et al (2006) About 50 researchers working in the field of systems genetics using mouse genetic reference populations (GRP) participated in the meeting and exchanged their results, phenotyping approaches, and data analysis tools for studying systems genetics.
keywords: analysis; data; gene; humans; mouse; strains; systems
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item: #2 of 104
id: cord-000261-ip32y0j5
author: Becker, Pablo D.
title: Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice
date: 2010-10-04
words: 5828
flesch: 41
summary: Thus, to fully exploit the Ig repertoire of human B cells in an in vivo setting, we explored the possibility to raise mAbs following de novo induction of human B cell responses in mice carrying elements of the human immune system (HIS). Similarly to methods based on the immortalization of human memory B cells from individuals that were either vaccinated or exposed to pathogens, our strategy exploits the antibody repertoire of human B cells which is likely to be different from that of B cells of mice expressing human Ig gene segments.
keywords: antibodies; antigen; cells; clones; human; igg; igm; mabs; mice; mouse; specific; vaccinated
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item: #3 of 104
id: cord-000539-uh3q65we
author: Zhang, Yi
title: Acute Respiratory Distress Syndrome Induced by a Swine 2009 H1N1 Variant in Mice
date: 2012-01-03
words: 4631
flesch: 47
summary: The typical 2009 H1N1 virus, such as A/California/04/2009 (CA/04), can efficiently replicate in mouse lungs without prior host adaptation. Interferon (IFN)-c, monocyte chemotactic protein (MCP)-1, and tumor necrosis factor (TNF) dramatically increased in mouse lungs on days 6-8 p.i.
keywords: ards; day; h1n1; infection; influenza; lung; mice; p.i; sd/09; virus
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item: #4 of 104
id: cord-001569-jd028cyg
author: dos Santos, Gimena
title: Vimentin regulates activation of the NLRP3 inflammasome
date: 2015-03-12
words: 8486
flesch: 42
summary: Our data obtained in vimentin knockout mice and vimentin-null cells suggest that vimentin is required for NLRP3 inflammasome activation. We investigated the role of vimentin, a type III intermediate filament, in this process using three well-characterized murine models of ALI known to require NLRP3 inflammasome activation.
keywords: activation; asbestos; bleomycin; caspase-1; cells; collagen; fibrosis; fig; il-1b; inflammasome; inflammation; lps; lung; mice; nlrp3; protein; vim; vimentin
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item: #5 of 104
id: cord-001675-9717nzr7
author: Sugiyama, Michael G.
title: The Tie2-agonist Vasculotide rescues mice from influenza virus infection
date: 2015-06-05
words: 4835
flesch: 39
summary: Most deaths from influenza virus infection occur due to pulmonary complications, in particular the development of acute respiratory distress syndrome (ARDS) 10, 11 , a potentially fatal syndrome of pulmonary edema that occurs due to increased permeability of the lung microvasculature 12, 13 . Here we report that administration of Vasculotide significantly improves survival from influenza virus infection, even when started several days post-infection.
keywords: endothelial; fig; hours; infection; influenza; lung; mice; survival; tie2; vasculotide; virus
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item: #6 of 104
id: cord-001958-2gt3fwpy
author: Meseda, Clement A.
title: Percutaneous Vaccination as an Effective Method of Delivery of MVA and MVA-Vectored Vaccines
date: 2016-02-19
words: 8186
flesch: 35
summary: In the work described here, we demonstrate in mouse models that percutaneous inoculation of MVA elicited protective immune responses against lethal intranasal challenge with the Western Reserve (WR) strain of vaccinia virus, and at low doses of MVA, lower morbidity was recorded in mice that were vaccinated via the percutaneous route than in those immunized via the intramuscular or subcutaneous routes. Similar to studies investigating MVA as a smallpox vaccine, preclinical and clinical evaluation of MVA-vectored vaccines in development has relied predominantly on the use of intramuscular, intradermal or subcutaneous routes of MVA delivery.
keywords: ankara; groups; influenza; mice; mva; pfu; responses; skin; smallpox; vaccination; vaccine; vaccinia; virus
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item: #7 of 104
id: cord-002341-v4r5d26a
author: Chan, Jasper Fuk-Woo
title: Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons
date: 2016-11-12
words: 7158
flesch: 40
summary: Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys Characterization of lethal Zika virus infection in AG129 mice Fatal sickle cell disease and Zika virus infection in girl from Colombia Zika virus infection of the central nervous system of mice Acute glomerulonephritis in dengue haemorrhagic fever in the absence of shock, sepsis, haemolysis or rhabdomyolysis Isolation of infective Zika virus from urine and saliva of patients in Brazil Comparative analysis between Flaviviruses reveals specific neural stem cell tropism for Zika virus in the mouse developing Neocortex Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study Zika virus associated with Meningoencephalitis Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus Development and evaluation of novel realtime reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses Treatment with Lopinavir/ritonavir or interferon-beta1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset Zika fever and congenital Zika syndrome: an unexpected emerging arboviral disease Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs An observational study of dengue fever in a tertiary care hospital of eastern India The Brazilian Zika virus strain causes birth defects in experimental models Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil Zika virus. In addition to the reported findings of detectable virus particles and/or RNA in the brain, spinal cord, kidney, spleen, liver, testis, ovary, heart, lung, muscle, and blood of types I/II interferon-signaling-/receptor-deficient mice with ZIKV infection, our study identified intestine, pancreas, and salivary gland as other possible tissues and anatomical sites for virus infection (Dick, 1952; Lazear et al., 2016; Dowall et al., 2016; Aliota et al., 2016; Rossi et al., 2016) .
keywords: dexamethasone; dpi; et al; fig; groups; infection; inoculation; interferon; mice; mouse; treatment; virus; weight; zika; zikv
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item: #8 of 104
id: cord-003315-r1wkx0ml
author: Jacobs, Sophie
title: Species Specificity of Type III Interferon Activity and Development of a Sensitive Luciferase-Based Bioassay for Quantitation of Mouse Interferon-λ
date: 2018-11-01
words: 6248
flesch: 52
summary: Species specificity index was calculated as the ratio between the relative antiviral activity on cells of homologous to nonhomologous species (eg, for mouse IFN: relative activity in mouse cells/relative activity in human cells). IFN activity was measured in Fawa-l-luc cells for IFN concentrations that yielded equivalent luciferase activities (20,000 RLU) before UV treatment (250 pg/mL mIFN-l2 and mIFN-l3, 125 pg/mL human IFN-l1, 10 ng/mL huIFN-l2, 500 pg/mL huIFN-l3, and 62.5 pg/mL huIFN-l4).
keywords: activity; assay; cells; detection; human; ifn; ifns; iii; mouse; mouse ifn; samples; species; type
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item: #9 of 104
id: cord-003389-0yh5k6jk
author: Patton, John B.
title: Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum
date: 2018-12-12
words: 8003
flesch: 45
summary: The immunodeficient scid mouse as a model for human lymphatic filariasis Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans The SCID mouse mutant: definition, characterization, and potential uses Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice Methylprednisolone acetate induces, and Delta7-dafachronic acid suppresses, Strongyloides stercoralis hyperinfection in NSG mice Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury Humoral immunity in humanized mice: a work in progress AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3 BLT humanized mice as a small animal model of HIV infection Ivermectin resistance in Onchocerca volvulus: toward a genetic basis Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity Protective immunity to the larval stages of Onchocerca volvulus is dependent on Toll-like receptor 4 Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae Differential cytokine and antibody responses to adult and larval stages of Onchocerca volvulus consistent with the development of concomitant immunity Cryopreservation of infective larvae of Onchocerca volvulus (Filarioidea: Onchocercidae) Infection of tissue culture cells with bloodstream trypomastigotes of Trypanosoma cruzi Detection of Onchocerca volvulus infection by O-150 polymerase chain reaction analysis of skin scratches We hypothesized that highly immunodeficient NSG mice would support the survival and maturation of O. volvulus and alteration of the host microenvironment through the addition of various human cells and tissues would further enhance the level of parasite maturation.
keywords: animal; cells; development; human; infection; larvae; mice; mouse; nsg; nsg mice; onchocerca; parasites; stem; volvulus; weeks; worms
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item: #10 of 104
id: cord-003634-iq0e1qp1
author: Otxoa-de-Amezaga, Amaia
title: Microglial cell loss after ischemic stroke favors brain neutrophil accumulation
date: 2018-12-22
words: 10363
flesch: 46
summary: Several lines of evidence support that after brain ischemia neutrophils release proteolytic enzymes, promote matrix metalloproteinase (MMP) activation, and cause BBB breakdown Based on previous observations of microglia phagocytosing neutrophils recruited to the ischemic brain lesion, we hypothesized that microglial cells might control neutrophil accumulation in the injured brain.
keywords: brain; cells; core; csf1r; days; fig; green; human; infarction; ischemia; lesion; mice; microglia; neutrophils; parenchyma; periphery; stroke; time; tissue
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item: #11 of 104
id: cord-004416-qw6tusd2
author: Krishna, Smriti M.
title: Development of a two-stage limb ischemia model to better simulate human peripheral artery disease
date: 2020-02-26
words: 8274
flesch: 42
summary: Low capillary density has been reported in the gastrocnemius muscle of PAD patients and animal HLI models and associated with functional impairment 38, 39 . Twenty eight days after HLI induction, the concentrations of circulating cytokines were similar in the two models studied.
keywords: angiogenesis; artery; blood; exercise; fig; gastrocnemius; hli model; ischemia; limb; mice; model; muscle; sham; stage; stage hli; test; treadmill; vegf
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item: #12 of 104
id: cord-004663-a47pkh8q
author: Tardieu, M.
title: Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)
date: 1982
words: 3426
flesch: 43
summary: or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level.
keywords: infection; lesions; mice; p.i; virus
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item: #13 of 104
id: cord-004774-fvf671jn
author: Kjeldsberg, Elisabeth
title: Detection of astroviruses in gut contents of nude and normal mice
date: 1985
words: 1609
flesch: 52
summary: In this note we report the detection of astrovirus-like partieles in gut contents from nude mice, with and without clinical signs of illness, and from normal symptomless mice in association with an outbreak of diarrhea. No attempt was made to quantify the amount of virus in the samples, but there appeared to be a higher number of virus particles in the samples from animals with diarrhea than from those without.
keywords: animals; diarrhea; mice; particles; virus
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item: #14 of 104
id: cord-004879-pgyzluwp
author: None
title: Programmed cell death
date: 1994
words: 81833
flesch: 47
summary: 8cl-2(z is a mitochondrial or perinuclear-associated oncoprotein that prolongs the life span of a variety of cell types by interfering with programmed cell death. Single and repetitive uptake and release of CPZ were measured in each cell type after individual exposure or exposure in any combination of cell types: In 2 hour competitive uptake studies fibreblasts reached 1.7 and 2.6 times the concentrations of C6-and ROC-cells, :respectively.
keywords: acid; activation; activity; addition; adult; amino; analysis; animals; antibodies; binding; brain; calcium; cdna; cell lines; cells; changes; cloned; complex; concentrations; conditions; contrast; control; cultures; current; data; days; decrease; development; different; differentiation; dna; domain; early; effects; end; enzyme; epithelial; experiments; expression; extracts; factor; family; fold; form; formation; function; fusion; gene; gene expression; growth; homology; hormone; human; increase; induction; infected; inhibition; institut; interaction; intracellular; kda; kinase; levels; major; mammalian; mechanisms; medium; membrane; mice; molecular; mouse; mrna; muscle; mutant; nerve; neuronal; neurons; new; non; nuclear; nucleus; number; order; pathway; phosphorylation; play; positive; potential; presence; present; process; production; promoter; properties; protein; protein expression; rat; rate; rats; reaction; receptor; recombinant; recombination; region; regulation; release; replication; response; results; rna; role; sequence; signal; sites; species; specific; stage; stimulation; structure; studies; study; subunit; surface; synthesis; system; t cells; target; terminal; time; tissue; tnf; transcription; treatment; tumor; type; university; virus; vitro; vivo; yeast
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item: #15 of 104
id: cord-006229-7yoilsho
author: None
title: Abstracts of the 82(nd) Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 18(th) Annual Meeting of the Network Clinical Pharmacology Germany (VKliPha) in cooperation with the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH)
date: 2016-02-06
words: 134020
flesch: 40
summary: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC) and is characterized by a metabolic shift towards enhanced aerobic glycolysis and hence, increased lactate production. Further studies will be performed to clarify whether silver ions and/or silver nanoparticles could affect the specific N-acetylation of arylamines in human cells.
keywords: acid; activation; activity; addition; agents; agonist; aim; analysis; animal; anti; approach; assay; assessment; background; barrier; binding; blood; body; brain; camp; cancer; cancer cells; cardiac; cell death; cell line; cells; cgmp; changes; channels; chemical; chronic; clinical; complex; compounds; concentrations; conclusion; conditions; contrast; control; culture; current; damage; data; days; death; development; differences; different; differentiation; disease; dna; dose; drug; e.g.; effects; endothelial; enzyme; experiments; exposure; expression; factor; fibroblasts; findings; flow; fold; food; formation; fret; function; g protein; gene; germany; group; growth; health; heart; human; impact; increase; induction; inflammation; influence; inhibition; inhibitors; insulin; interaction; intracellular; kidney; levels; line; liver; loss; low; lung; mcpd; mechanisms; membrane; metabolism; metabolites; methods; mice; migration; model; mouse; mrna; nanoparticles; neurons; new; non; novel; number; oct1; order; p<0.05; parameters; pathways; patients; phosphorylation; plasma; platelet; potential; presence; present; primary; processes; products; proliferation; properties; protein; protein expression; rats; receptor; receptor activation; reduced; reduction; regulation; release; research; resistance; response; results; risk; role; samples; set; signaling; skin; small; specific; stimulation; stress; studies; study; substances; system; target; test; testing; therapy; time; tissue; total; toxicity; transcription; treatment; tumor; type; uptake; vitro; vivo; vs.; weight
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item: #16 of 104
id: cord-006230-xta38e7j
author: None
title: Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V.
date: 2012-02-22
words: 136000
flesch: 40
summary: In in-vitro studies on rat and canine mast cells and human mast cell leukemia cells HMC1.2 BZ at micromolar concentrations inhibited mediator release which appeared to be related to an inhibition of the intracellular cAMP pathway. Previous work showed that mouse cells lacking the immediate-early gene c-fos are hypersensitive to ultraviolet (UVC) light.
keywords: acid; activation; activity; acute; addition; adducts; agonist; aim; analysis; animals; anti; apoptosis; approach; assay; assessment; binding; blood; brain; calcium; camp; cancer; cancer cells; cardiac; cell line; cells; cellular; cgmp; changes; channels; chronic; clinical; complex; compounds; concentration; conclusion; conditions; contrast; control; current; damage; data; days; death; decrease; deficient; development; differences; differentiation; disease; dna; dose; drug; e.g.; effects; endothelial; enzyme; evidence; experiments; exposure; expression; factor; failure; family; fibroblasts; findings; fold; food; formation; function; für; g protein; gene; gene expression; germany; glucose; growth; health; heart; human; hypertrophy; increase; induction; inflammation; inhibition; inhibitors; institut; insulin; interaction; intracellular; kidney; kinase; leads; levels; like; line; liver; loss; low; lung; macrophages; mechanisms; membrane; methods; mice; model; mouse; mrna; muscle cells; mutations; nanoparticles; ndpk; non; novel; number; pain; pathway; patients; pcr; pharmakologie; phosphorylation; plasma; potential; presence; present; pressure; primary; processes; production; products; proliferation; promoter; properties; protein; protein expression; pulmonary; rats; receptor; reduced; regulation; release; response; results; risk; rkip; role; ros; samples; selective; signaling; site; skin; smooth; specific; stimulation; stress; studies; study; substances; subunits; synthesis; system; t cells; target; test; tested; therapy; time; tissue; toxicity; toxikologie; toxin; transcription; transport; treatment; tumor; tumor cells; type; universität; uptake; values; vascular; vitro; vivo; water
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item: #17 of 104
id: cord-006588-aavpj5r3
author: Schwarte, L.A.
title: Mechanical ventilation of mice
date: 2000
words: 5718
flesch: 33
summary: Attempts to monitor mechanical mouse ventilation are complicated by the fact that even standard variables for ventilation are not established yet or show conßicting results (see Table 1 ). Especially the determination of the end-tidal CO 2 (etCO 2 ), as a measure for alveolar CO 2 -concentration, is described as essential to maintain stable physiological parameters during mechanical mouse ventilation (7) .
keywords: airway; blood; endotracheal; gas; lung; mice; mouse; murine; pressure; ventilation; ventilatory
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item: #18 of 104
id: cord-007094-ur9sz21s
author: Mahabir, Esther
title: Rodent and Germplasm Trafficking: Risks of Microbial Contamination in a High-Tech Biomedical World
date: 2008-01-01
words: 6262
flesch: 26
summary: GV-SOLAS Annual Meeting Guidelines for the Humane Transportation of Research Animals Establishing an appropriate period of acclimatization following transportation of laboratory animals Maintenance of pluripotency in mouse embryonic stem cells persistently infected with murine coronavirus Naturally occurring murine norovirus infection in a large research institution Risk assessment of mouse hepatitis virus infection via in vitro fertilization and embryo transfer by the use of zona-intact and laser-microdissected oocytes Rederivation of inbred strains of mice by means of embryo transfer Tissue distribution and duration of mouse hepatitis virus in naturally infected immunocompetent ICR (CD-1) and immunodeficient athymic nude-nu mouse strains used for ovarian transplantation and in vitro fertilization Helicobacter typhlonius was detected in the sex organs of three mouse strains but did not transmit vertically Prevalence of naturally occurring viral infections, Mycoplasma pulmonis and Clostridium piliforme in laboratory rodents in Western Europe screened from Cryopreservation of transgenic mouse lines Manual of the International Embryo Transfer Society Rederivation of mice by means of in vitro fertilization and embryo transfer Guidance on the transport of laboratory animals Rescue of a transgenic mouse line by transplantation of a frozen-thawed ovary obtained postmortem Failure to infect embryos after virus injection in mouse zygotes Sendai (parainfluenza 1) infection of mouse eggs Rederivation of transgenic and genetargeted mice by embryo transfer Constructing the mammalian egg zona pellucida: Some new pieces of an old puzzle Resynchronization of the circadian corticosterone rhythm after a light/dark shift in juvenile and adult mice Production of normal young following transfer of mouse embryos obtained by in vitro fertilization using cryopreserved spermatozoa Transmission of mouse minute virus (MVM) but not mouse hepatitis virus (MHV) following embryo transfer with experimentally exposed in vivo-derived embryos Prevalence of mouse norovirus (MNV) in a large breeding and experimental mouse facility.
keywords: animals; cells; embryos; et al; laboratory; live; mice; mouse; murine; spermatozoa; transfer; virus; viruses
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item: #19 of 104
id: cord-007726-bqlf72fe
author: Rydell-Törmänen, Kristina
title: The Applicability of Mouse Models to the Study of Human Disease
date: 2018-11-09
words: 7993
flesch: 32
summary: In this chapter, an in-depth analysis of these similarities and differences is provided to allow researchers to use mouse models of human disease and primary cells derived from these animal models under the most appropriate and meaningful conditions. Using specific examples of mouse models of human lung disease, i.e., asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis, this chapter explores the most salient features of mouse models of human disease and provides a full assessment of the advantages and limitations of these models, focusing on the relevance of disease induction and their ability to replicate critical features of human disease pathophysiology and response to treatment.
keywords: administration; airway; animals; asthma; cell; differences; disease; fibrosis; human; inflammation; lung; mice; model; mouse; research
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item: #20 of 104
id: cord-009388-k3exf8a4
author: Agarwal, Yash
title: Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies
date: 2020-04-10
words: 5870
flesch: 27
summary: The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs High activation and skewed T cell differentiation are associated with low IL-17A levels in a hu-PBL-NSG-SGM3 mouse model of HIV infection Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation HIV-1 infection and pathogenesis in a novel humanized mouse model Humanized Mice Engrafted With Human HSC Only or HSC and Thymus Support Comparable HIV-1 Replication, Immunopathology, and Responses to ART and Immune Therapy Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and CB-17-scid/bg immunodeficient mice Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells Humanized mice for immune system investigation: progress, promise and challenges Flt3L-mediated expansion of plasmacytoid dendritic cells Suppresses HIV infection in humanized mice RAG2(-/-)gamma(-/-)(c) In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell kick and kill in strategy for virus eradication Immunization of BLT humanized mice redirects T cell responses to Gag and reduces acute HIV-1 viremia In vivo excision of HIV-1 provirus by saCas9 and multiplex single-guide RNAs in animal models A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice Stem-cell based engineered immunity against HIV infection in the humanized mouse model A humanized mouse model generated using surplus neonatal tissue Cryptopatches are essential for the development of human GALT Generation of improved humanized mouse models for human infectious diseases Human immune system mice: current potential and limitations for translational research on human antibody responses Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rγnull mice The analysis of the functions of human B and T cells in humanized NOD/shi-scid/ cnull (NOG) mice (hu-HSC NOG mice)
keywords: blt; cells; development; hiv; human; immunodeficient; infection; lymphoid; mice; model; mouse; system; tissues; transmission
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item: #21 of 104
id: cord-010187-ymhcfyxx
author: Gromeier, Matthias
title: Mouse neuropathogenic poliovirus strains cause damage in the central nervous system distinct from poliomyelitis
date: 2005-03-25
words: 5150
flesch: 37
summary: Mouse neurovirulent strains of poliovirus type 2 differed from mouse neurovirulent poliovirus type 1 derivatives in their ability to induce CNS lesions. The outcome of infection of mice with mouse-adapted poliovirus strains has been described previously mainly in terms of paralysis and death, and it was generally assumed that these strains produce the same disease syndromes in normal mice and in mice transgenic for the human poliovirus receptor (hPVR-tg mice).
keywords: clinical; disease; hpvr; mice; mouse; poliomyelitis; poliovirus; strains; type
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item: #22 of 104
id: cord-010278-loey5xq9
author: Huh, Changgoo
title: Structural organization, expression and chromosomal mapping of the mouse cystatin-C-encoding gene (Cst3)
date: 1995-01-23
words: 2850
flesch: 53
summary: There is evidence that induction of gene expression by TGF-13 is mediated by transcription factor AP-1. In this paper, we report the structural organization and expression of the mouse Cst3 gene, compare its regulatory elements with that of other Cst genes and map the Cst3 gene in the mouse.
keywords: cst3; cystatin; gene; mouse; region; sequence
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item: #23 of 104
id: cord-013023-uanozm00
author: Crouse, Richard B
title: Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency
date: 2020-09-18
words: 13317
flesch: 41
summary: To test this hypothesis, we measured relative levels of BLA ACh (ACh signaling), cholinergic NBM-BLA terminal fiber activity (BLA ACh signal origin), and the activity of BLA principal neurons (BLA output) across all phases of learning in an appetitive operant learning task to evaluate how BLA output and ACh signaling are related to behavioral performance in this paradigm. Traces of signal and reference channels (%DF/F0) during nose pokes are shown in Figure 2 figure supplement 1B-C. Incorrect nose pokes on the last day of PT versus Training Day 1 shown in Figure 2 -figure supplement 2B. (D) Heatmap of BLA ACh signaling in Mouse 1 across all training phases, aligned to tone onset (Tone), correct nose poke (NP), and receptacle entry (Rec).
keywords: ach; activity; bla; cholinergic; cue; et al; fiber; figure; incorrect; learning; mice; nbm; neurons; nose; nose pokes; pokes; pre; reward; signaling; stimulation; task; tone; training
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item: #24 of 104
id: cord-015021-pol2qm74
author: None
title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches
date: 1994
words: 162543
flesch: 45
summary: Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases.
keywords: acid; activation; activity; acute; addition; adhesion; administration; aim; analysis; animals; anti; antibodies; antibody; ards; arterial; bacteria; binding; blood; blood cells; blood levels; blood samples; body; burn; capacity; cardiac; cause; cd14; cells; cellular; challenge; changes; circulating; clinical; clp; complement; complications; concentrations; conclusion; conditions; contrast; control; control group; control patients; correlation; course; csf; cultured; cytokine levels; cytokine production; cytokines; damage; data; days; death; decrease; development; differences; disease; dose; dysfunction; effect; elevated; elisa; endothelial; endotoxin; endotoxin levels; evidence; experimental; expression; factor; failure; flow; following; formation; function; gene; gram; group; growth; gut; hepatic; high; host; hours; hrs; human; il-1; il-6; il-6 levels; il-8; ill; immune; increased; induction; infection; inflammation; inflammatory; infusion; inhibitor; injury; ischemia; leukocytes; levels; lipid; liver; lps; lung; lymphocytes; macrophages; mean; mechanisms; mediators; membrane; methods; mice; model; mof; molecules; monoclonal; monocytes; mortality; multiple; necrosis; negative; neutrophils; new; non; normal; number; operation; organ; organ failure; organ injury; outcome; oxygen; p<0.05; parameters; patients; period; peritoneal; phase; placebo; plasma; plasma levels; plasma tnf; play; pmn; positive; post; postoperative; potential; presence; present; pressure; process; production; protein; pulmonary; rate; rats; receptor; reduced; related; release; reperfusion; response; results; risk; role; saline; samples; score; sepsis; sepsis patients; septic; serum; serum levels; severity; sham; shock; sirs; soluble; specific; state; stimulation; studies; study; surface; surgery; survival; syndrome; synthesis; system; systemic; t cells; test; therapeutic; therapy; time; tissue; tnf; tnf levels; tnf production; tnf release; total; trauma patients; treated; treatment; tumor; type; use; values; vascular; vitro; vivo; wound
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item: #25 of 104
id: cord-015147-h0o0yqv8
author: None
title: Oral Communications and Posters
date: 2014-09-12
words: 73903
flesch: 39
summary: After 3 months of exposures, inflammatory cells in bronchoalveolar lavage fluid were increased in both the HCR-and LCR-smokeexposed(SE) animals compared to air-exposed controls (p<0.001); however there was a 2-3-fold increase in the number of neutrophils and lymphocytes in the LCR-over the HCR-SE group (p<0.001).Histopathology revealed there was greater inflammation and lung damage present in the LCR-versus HCR-SE group (p<0.05). This causes the symptoms of the early phase of AI and the onset of the late phase characterized by the penetration in the inflamed tissue of inflammatory cells, notably the eosinophils.
keywords: activation; activity; acute; addition; adhesion; administration; aim; alpha; analysis; animals; anti; antibodies; antibody; arthritis; associated; beta; binding; blood; bone; cancer; cartilage; cells; chronic; complex; conditions; control; cox-2; cytokines; data; day; days; development; disease; dose; effect; expression; factor; function; gene; group; hours; human; il-1b; il-6; immune; increase; induction; inflammation; inflammatory; inhibited; inhibition; inhibitors; injection; injury; joint; kinase; leukocyte; levels; lps; lung; macrophages; mechanisms; mediators; methods; mice; mif; model; molecular; molecules; monocytes; mouse; mrna; neutrophils; new; novel; number; p38; pathways; patients; pcr; plasma; potential; presence; present; production; protein; rats; receptor; reduced; regulation; release; research; response; results; rheumatoid; role; selective; serum; signaling; skin; specific; stimulation; studies; study; synthesis; system; t cells; therapeutic; time; tissue; tnf; tnfa; treatment; tumor; type; university; vitro; vivo
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item: #26 of 104
id: cord-015569-vy49r1zd
author: None
title: Abstracts from the 45(th) Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7(th), 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University)
date: 2012-05-17
words: 18896
flesch: 49
summary: However, mechanism of recognition of taste receptor cells which express appropriate taste receptor is still unknown. Using calcium imaging and immunocytochemistry, we revealed that ATP activates type II and III taste cells and HCl activates type III taste cells, and also that HCl and ATP activate separate subpopulations of taste cells.
keywords: acid; activity; cells; dashi; flavor; food; intake; mice; nerve; odor; olfactory; patients; preference; rats; receptor; responses; results; saliva; sensory; solution; stimulation; stimuli; study; subjects; sucrose; swallowing; system; taste; taste cells; type; umami; water
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item: #27 of 104
id: cord-017521-z9l9c83i
author: Kubota, Tetsuya
title: Cuff-Induced Neointimal Formation in Mouse Models
date: 2015-11-05
words: 6827
flesch: 36
summary: Mouse arteries, unlike the arteries of larger animals, are too small for transluminal injury to be induced with a balloon. eNOS-KO mice exhibit impaired ACh-induced vascular relaxation [53] .
keywords: artery; atherosclerosis; cells; cuff; endothelial; formation; injury; ko mice; mice; placement; receptor; vascular
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item: #28 of 104
id: cord-021413-1ht1xm88
author: Kraft, Lisbeth M.
title: Viral Diseases of the Digestive System
date: 2013-10-21
words: 14272
flesch: 41
summary: A number of cell systems have been successfully employed for in vitro growth of mouse hepatitis viruses: MHV-C in mouse embryo explants (Mosley, 1961) ; MHVl in newborn mouse kidney explants (Starr and Pollard, 1959) ; MHV-S in mouse embryo explants (Compels, 1953) and in liver (Gallily et aL, 1964) ; MHV-B in liver cell monolayers (Paradisi and Piccinino, 1968) ; MHV3 in liver explants (Vainio, 1961) ; MHV-B in liver cells (Miyazaki et aL, 1957) ; MHV2 and MHV3 in DBT cells (Hirano et aL, 1978; Takayama and Kim, 1978) ; and various strains in NCTC 1469 cells (David-Ferreira and Manaker, 1965; Wilsnack etaL, 1971; Hartley and Rowe, 1963) . I. Isolation and biological prop erties of the virus Serological inter relationships of murine hepatitis viruses Production of high-titer bovine rotavirus with trypsin Murine virus contaminants of leukemia viruses and transplantable tumors Reovirus type 3 infection in laboratory mice Temperature-sensitive mutants of reovirus type 3: Studies on the synthesis of viral RNA Effect of corticosteroids on mouse hepatitis virus infection An electron microscope study of the development of a mouse hepatitis virus in tissue culture cells Importance of a new virus in acute sporadic enteritis in children Comparison of the morphology of three coronaviruses Classification of rotaviruses: Report from the Worid Health Organization/Food and Agriculture Or ganization Comparative Virology Program Serologic study on the prevalence of murine viruses in five Canadian mouse colonies A virus related to that causing hepatitis in mice (MHV) Immunopathology of mouse hepatitis virus type 3. II.
keywords: acute; agent; animals; cells; colony; coronaviruses; diarrhea; disease; edim; electron; et al; hepatitis; hepatitis virus; human; infant; infection; kraft; mhv; mice; mouse; mouse hepatitis; murine; nude; reovirus; rotavirus; strain; studies; type; virus; viruses
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item: #29 of 104
id: cord-021499-up5vftj4
author: Brayton, Cory
title: Viral Infections
date: 2007-09-02
words: 20933
flesch: 41
summary: Murine rotavirus-A/EDIM (commonly referred to as 'mouse rotavirus' or 'epizootic diarrhoea of infant mice virus') is a nonenveloped, segmented double-stranded RNA virus of the family Reoviridae, genus Rotavirus. Mouse thymic virus was detected during studies in which samples from mice were passaged in newborn mice.
keywords: age; animals; antibodies; barthold; cells; colonies; council; disease; et al; immune; infection; inoculation; laboratory; laboratory mice; lesions; materials; mhv; mice; mouse; mpv; murine; national; research; research council; results; strains; virus; viruses; weeks
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item: #30 of 104
id: cord-022082-1dq623oe
author: Greaves, Peter
title: Respiratory Tract
date: 2007-09-28
words: 19712
flesch: 22
summary: ^^^ Plasticembedded sections also show the inclusions in other pulmonary cells including pneumocytes attached to the alveolar walls, from which they can be seen discharging into the alveolar spaces. In contrast to findings in people, squamous cell lung tumours are only occasionally seen arising spontaneously in laboratory animals.
keywords: administration; agents; airways; alveolar; animals; bronchial; cells; changes; drug; effects; epithelium; fibrosis; humans; hyperplasia; inhalation; laboratory; laboratory animals; lesions; lung; macrophages; mice; mucosa; nasal; olfactory; pulmonary; rats; respiratory; species; studies; study; tissue; toxicity; tract; type
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item: #31 of 104
id: cord-022324-tcltmhi7
author: Barthold, Stephen W.
title: MOUSE HEPATITIS VIRUS BIOLOGY AND EPIZOOTIOLOGY
date: 2012-12-02
words: 5623
flesch: 38
summary: This fact is most evident in T cell deficient, athymic nude mice, in which MHV titers initially parallel their heterozygous euthymic counterparts, but continue to rise as hétérozygotes recover (73) Only a single study has demonstrated delayed-type hypersensitivity in MHV immunized mice (62). Nevertheless, recent work is suggesting that selective cell tropism can take place with specific MHV strains and that host cell type can influence the outcome of MHV infection.
keywords: cells; disease; hepatitis; host; infection; jhm; mhv; mice; mouse; strains; virus
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item: #32 of 104
id: cord-022353-q2k2krnm
author: W. Quimby, Fred
title: Clinical Chemistry of the Laboratory Mouse
date: 2007-09-02
words: 30268
flesch: 42
summary: Although we hope all readers of this chapter will benefit from this section on assays and instruments, the primary purpose of this chapter is to briefly introduce the reader to areas where methods in clinical chemistry are changing and provide sources of information for services, reagents (including test kits), and instrumentation, specifically for testing biomarkers (including traditional analytes) in mouse serum, plasma, or urine. Growth in the number of reagents capable of quantitating analytes in mouse serum is illustrated in Table 6 -2.
keywords: acid; activity; addition; age; analytes; assays; atherosclerosis; binding; biomarkers; blood; cells; chemistry; chemokines; cholesterol; complement; corticosterone; development; disease; effects; elisa; enzyme; et al; expression; factor; function; gene; glucose; growth; hdl; hepatic; hormone; human; insulin; kits; ldl; levels; liver; metabolism; mice; mouse; murine; muscle; new; plasma; production; protein; quimby; receptor; response; role; secretion; serum; strains; surface; tissue; total; transgenic; type
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item: #33 of 104
id: cord-022393-s26d54ew
author: E. Newcomer, Christian
title: Zoonoses and Other Human Health Hazards
date: 2007-09-02
words: 17048
flesch: 33
summary: The biomedical literature contains numerous reports of zoonotic diseases and parasitic infestations from laboratory mice and their wild counterparts. Wild caught mice that are maintained in naturalistic housing environments in the laboratory, laboratory mice that have contact with wild or feral mice, and mice kept as pets in the home environment are examples of animal management conditions that would be conducive to the expression and transmission of zoonotic diseases and other mouse-associated hazards.
keywords: allergen; allergy; animal; bite; cases; choriomeningitis; colonies; disease; et al; exposure; fever; health; host; humans; individuals; infection; laboratory; laboratory animal; laboratory mice; lcmv; mice; mite; moniliformis; mouse; patients; personnel; research; risk; rodents; salmonella; species; studies; symptoms; transmission; virus; wild
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item: #34 of 104
id: cord-022505-17khcmta
author: Delaney, Martha A.
title: Rodentia
date: 2018-10-26
words: 10531
flesch: 32
summary: The deliberate poisoning of free-ranging rats and mice results in inadvertent toxicity of nontarget animals including other rodents, such as squirrels or carnivorous predators that consume affected carcasses. Unlike other rodents, naked mole-rats, beavers, and woodchucks do not require dietary vitamin D and toxicity can develop if they are fed rodent chow or diets supplemented with vitamin D. Lesions consistent with calcinosis cutis and circumscripta can develop in naked mole-rats fed such diets.
keywords: cells; chronic; disease; fibrosis; fig; guinea; hamsters; histologic; infection; krinke; lesions; liver; mice; mole; mouse; necrosis; pigs; rats; rattus; rodents; skin; species; squirrels; virus; woodchuck; zoonotic
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item: #35 of 104
id: cord-022888-dnsdg04n
author: None
title: Poster Sessions
date: 2009-08-19
words: 189173
flesch: 41
summary: Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines.
keywords: + cells; ability; absence; activity; addition; analysis; antibodies; antibody; antigen; apoptosis; apoptotic; assay; associated; autoimmune; b cells; b t; binding; blood; bone; c mice; cancer cells; capacity; cd4; cd8 +; cd8 cells; cd8 t; cell activation; cell activity; cell culture; cell cycle; cell death; cell development; cell differentiation; cell epitopes; cell function; cell level; cell lines; cell membrane; cell population; cell proliferation; cell receptor; cell responses; cell subsets; cell surface; cell tolerance; cell types; cells cells; changes; chronic; class; clinical; colitis; complex; conclusion; contrast; control; control cells; cross; ctl; cytokine; cytokine production; cytometry; cytotoxic t; data; day; days; dcs; deficient; delta t; dendritic; disease; dna; early; effector cells; effector t; effects; elisa; expansion; experiments; expression; expression levels; factor; family; findings; flow; following; formation; function; gamma; gd cells; gd t; gene; gene expression; group; high; hiv; hla; host; human; ifn; ifng; igg; il-10; il-2; il-4; il-6; immune; immunity; increase; independent; induction; infected; infection; inflammation; inflammatory; inhibition; inkt; interaction; intracellular; levels; lps; macrophages; major; marrow cells; mast cells; mechanisms; membrane; memory t; methods; mhc; mice; model; molecules; monocytes; mouse; mouse t; mrna; murine; negative; neutrophils; new; nkt cells; non; normal; novel; number; objectives; pathway; patients; pcr; peptide; peripheral; plasma cells; play; positive; potential; presence; presentation; primary; production; promoter; protein; protein expression; receptors; regulation; regulatory; release; results; role; secretion; serum; signaling; skin; sle; specific; spleen; stem cells; stimulation; studies; study; surface expression; system; t cells; t em; t h; t helper; t lymphocytes; target cells; tcr; test; th1 cells; time; tissue; tlr; tnf; tolerance; transcription; treatment; tumor cells; type; university; vaccination; vaccine; vg9vd2 t; virus; vitro; vivo; work
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item: #36 of 104
id: cord-023026-2r84ndzv
author: None
title: Posters
date: 2013-06-14
words: 138804
flesch: 38
summary: Levels of expression of NG2 mRNA and protein in mouse glial cells are regulated by the neurotransmitter glutamate and overexpression of cleaved fragments modulates protein expression in murine glial cells. Interestingly, when we analyzed the in vitro expression pattern of rCD300f in brain cells by Q-PCR and immunohistochemistry, in addition to the expected expression in microglial cells, we detected expression of CD300f in oligodendrocytes and neurons.
keywords: activation; activity; acute; addition; adult; analysis; animals; anti; astrocytes; astroglial; axons; blood; brain; brain cells; brain injury; cells; cerebral; changes; chronic; cns; conditions; contrast; control; cord; cortex; cortical; cultures; cytokines; damage; data; days; death; decrease; derived; development; differentiation; disease; eae; effect; evidence; experiments; expression; expression levels; extracellular; factors; findings; formation; function; gene; gene expression; gfap; glial; glucose; glutamate; hippocampal; human; imaging; immune; increase; inflammation; inflammatory; inhibition; injection; injury; ischemic; ko mice; lactate; lesions; levels; loss; lps; macrophages; markers; mechanisms; membrane; metabolic; methods; mice; microglia; microglia activation; microglia cells; migration; model; molecules; morphology; mouse; mrna; myelin; nerve; neural; neurons; new; ng2 cells; non; number; oligodendrocytes; opcs; order; pathway; patients; pcr; phenotype; play; post; potential; precursor cells; presence; present; primary; processes; production; progenitor cells; progression; proliferation; properties; protein; protein expression; rats; receptors; reduced; regulation; release; remyelination; response; results; role; schwann cells; signaling; slices; spinal; stem cells; stress; studies; study; surface; survival; synaptic; system; test; therapeutic; time; tissue; transgenic; treatment; type; uptake; vitro; vivo; weeks
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item: #37 of 104
id: cord-023055-ntbvmssh
author: None
title: Immunogenicity
date: 2004-02-19
words: 64788
flesch: 56
summary: o present fragments of that antigen very efficiently t o T cells. 10. carrier (KLH) primed T cells were transferred in the presence or absence of antigen into irradiated, K-allotype distinct adoptive host.
keywords: ability; activity; amino; analysis; antibodies; antibody; antigen; b cells; binding; c e; c r; c t; cd3; cd4; cd8; cell activation; cell antigen; cell clones; cell epitopes; cell line; cell proliferation; cell receptor; cell response; cell surface; cells; chain; class; ctl; cytotoxic t; data; e l; e n; e s; epitopes; expression; f e; f t; gene; h e; hla; human; induced; l l; l s; l t; l y; levels; lines; mab; mhc; mice; molecules; monoclonal; mouse; mrna; murine; murine t; n g; n s; n t; non; o l; o n; p e; p l; p t; peptide; presence; present; production; proliferation; protein; r e; r l; recognition; region; residues; response; results; s c; s p; s s; sequence; specific; spleen cells; studies; t antigen; t cell; t e; t h; t helper; t lymphocytes; t o; t r; t s; t t; t u; t y; tcr; u l; w e
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item: #38 of 104
id: cord-023143-fcno330z
author: None
title: Molecular aspects of viral immunity
date: 2004-02-19
words: 43520
flesch: 44
summary: The immunohistological analysis suggests that CD8+ T cell dependent disappearence of marginal zone macrophages of follicular dendritic cells and of virus infected cells in general correlates with immunosuppression. Our studies indicate that MHC class I resmcted CD8+ cytotoxic T lymphocytes (CTLs) are activated in response to viral antigens leading to destruction of virus infected cells and loss of transgene expression.
keywords: activity; amino; analysis; animals; antibodies; antibody; antigen; b cells; binding; cd4; cd8; cell responses; challenge; class; clones; cns; ctl; ctl response; cytokines; cytotoxic t; days; different; disease; dna; epitopes; expression; gene; hiv; hla; host; human; ifn; immune; immunity; infected; infection; influenza; lcmv; levels; lymphocytes; memory; mhc; mice; model; molecules; mouse; murine; peptides; primary; production; protein; recognition; recombinant; replication; response; results; role; sequence; specific; spleen; strains; studies; t cells; type; vaccine; vaccinia; viral; virus; virus infection; viruses; vivo
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item: #39 of 104
id: cord-026009-rdhuc2n2
author: Anderson, Nancy L.
title: Pet Rodents
date: 2009-05-15
words: 14928
flesch: 56
summary: • Diagnosis is based on clinical signs, history, visualization of parasite, skin scrape, and cellophane tape test. • Clinical signs include erythema, pruritus, waxy debris, and excoriations behind the ears.
keywords: animals; cage; cause; chinchillas; common; culture; diagnosis; diarrhea; disease; examination; guinea; hamsters; infection; male; mice; pet; pigs; prognosis; rats; results; rodents; signs; skin; table; treat; treatment; tube; use
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item: #40 of 104
id: cord-031279-8rckjc41
author: Enriquez, Josue
title: Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery
date: 2020-09-02
words: 12349
flesch: 35
summary: The mouse ascending: perspectives for humandisease models Translation of research evidence from animals to humans Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies Can animal models of disease reliably inform human studies Genetic background and the dilemma of translating mouse studies to humans Thinking bedside at the bench: the NOD mouse model of T1DM The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases Using the mouse to model human disease: increasing validity and reproducibility Conservation and divergence in the transcriptional programs of the human and mouse immune systems A prescription for human immunology The habitual, diverse and surmountable obstacles to human immunology research Normalizing the environment recapitulates adult human immune traits in laboratory mice Species differences in the structure and function of the immune system Of mice and not men: differences between mouse and human immunology Wild mouse gut microbiota promotes host fitness and improves disease resistance Making mouse models that reflect human immune responses Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity Genomic responses in mouse models poorly mimic human inflammatory diseases Genomic responses in mouse models greatly mimic human inflammatory diseases Mice are not men An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity Manipulation of ambient housing temperature to study the impact of chronic stress on immunity and cancer in mice Thermoneutrality, mice, and cancer: a heated opinion Unstressing intemperate models: how cold stress undermines mouse modeling Regulatory T cells: mechanisms of differentiation and function Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice Immunologic selftolerance maintained by activated T cells expressing IL-2 receptor alphachains (CD25) Outbred ICR/CD1 mice display more severe neuroinflammation mediated by microglial TLR4/CD14 activation than inbred C57Bl/6 mice Allograft outcomes in outbred mice Extensive homeostatic T cell phenotypic variation within the collaborative Cross Revealing the complexity in CD8 T cell responses to infection in inbred C57B/6 versus outbred Swiss mice A versatile new model of chemically induced chronic colitis using an outbred murine strain Strains, stocks and mutant mice The origins and uses of mouse outbred stocks Development of fatal colitis in FVB mice infected with Citrobacter rodentium Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing Discordant susceptibility of inbred C57BL/6 versus outbred CD1 mice to experimental fungal sepsis Comparison of the susceptibilities of C57BL/6 and a/J mouse strains to Streptococcus suis serotype 2 infection Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection CD8(+) T cells: foot soldiers of the immune system Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts Angiogenesis in the atherosclerotic plaque )(4) isoform specific regulation of T-cell-dependent experimental colitis in mice Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues The pathogenic role of angiogenesis in rheumatoid arthritis Genetic background determines mouse strain differences in inflammatory angiogenesis Genetic strain differences in the development of peritoneal fibroproliferative processes in mice Despite these important advancements, only 10% of promising therapeutic strategies reported in mouse models of disease have gone on to be used as clinically-effective treatments in patients [2] [3] [4] .
keywords: c57bl/6; cells; development; disease; housing; human; infection; inflammation; mice; microbiota; models; mouse; outbred; responses; strains; studies; tnt
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item: #41 of 104
id: cord-032975-7hugs419
author: SUN, J. D.
title: Two-Week, Repeated Inhalation Exposure of F344/N Rats and B6C3F Mice to Ferrocene(1)
date: 1991-07-17
words: 3910
flesch: 42
summary: Male mice had a statistically significant decrease in liver and spleen weights after exposures to the two highest concentrations of ferrocene vapor, and a statistically significant increase in thymus weight after exposure to the highest concentration of ferrocene, when compared to control animals. Therefore, ferrocene vapor, as opposed to droplets or particles, is the most likely chemical form to be inhaled by people.
keywords: concentration; epithelium; exposure; ferrocene; lesions; liver; mice; rats; vapor; weight
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item: #42 of 104
id: cord-032982-xri24v40
author: MEDINSKY, M. A.
title: Effect of Inhaled Azodicarbonamide on F344/N Rats and B6C3F(1) Mice with 2-Week and 13-Week Inhalation Exposures
date: 1990-08-17
words: 6305
flesch: 56
summary: Other organ weights of either mice or rats were not influenced by ADA exposure (data not shown). However, there did appear to be a correlation between ADA exposure and loss of hepatocyte vacuolation.
keywords: ada; animals; biurea; exposure; group; lesions; lung; male; mice; rats; study; week
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item: #43 of 104
id: cord-103703-t03r6ny8
author: Nguyen-Tu, Marie-Sophie
title: Reduced expression of TCF7L2 in adipocyte impairs glucose tolerance associated with decreased insulin secretion, incretins levels and lipid metabolism dysregulation in male mice
date: 2020-05-20
words: 6257
flesch: 43
summary: Thus, our data indicate that loss of Tcf7l2 gene expression in adipocytes leads to impairments on metabolic responses which are dependent on gender, age and nutritional status. In the present study, we used a genetic model of ablation of TCF7L2 gene expression in mature adipocytes to determine whether TCF7L2 plays a role in adipocyte function, independent of its role in adipogenesis.
keywords: adipocytes; atcf7l2ko; beta; cell; expression; fatty; glucose; insulin; levels; mice; secretion; tcf7l2; tolerance
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item: #44 of 104
id: cord-104092-yau3r79c
author: Tamming, Renee J.
title: Atrx deletion in neurons leads to sexually-dimorphic dysregulation of miR-137 and spatial learning and memory deficits
date: 2019-04-13
words: 4073
flesch: 40
summary: Atrx loxP mice were mated with C57BL/6 mice expressing Cre recombinase under the control of the αCaMKII gene promoter 19 . The Shank family of scaffold proteins The glycine receptor Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits Disruption of the direct perforant path input to the CA1 subregion of the dorsal hippocampus interferes with spatial working memory and novelty detection A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre-Expressing Neurons Lipopolysaccharide-induced microglial activation induces learning and memory deficits without neuronal cell death in rats Learning, memory, and glial cell changes following recovery from chronic unpredictable stress Disruption of the perineuronal net in the hippocampus or medial prefrontal cortex impairs fear conditioning Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats Synaptic scaffold evolution generated components of vertebrate cognitive complexity X-linked alphathalassemia/mental retardation (ATR-X) syndrome: localization to Xq12-q21.31 by X inactivation and linkage analysis Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice Mecp2 organizes juvenile social behavior in a sex-specific manner MeCP2 Modulates Sex Differences in the Postsynaptic Development of the Valproate Animal Model of Autism Epidemiology of pervasive developmental disorders A higher mutational burden in females supports a female protective model in neurodevelopmental disorders Transcriptomic analysis of autistic brain reveals convergent molecular pathology Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism SHANK1 Deletions in Males with Investigation of sex differences in the expression of RORA and its transcriptional targets in the brain as a potential contributor to the sex bias in autism Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132 Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory Supplementary Figure 5: Transcriptional profiling reveals dysregulation of presynaptic genes in Atrx-FoxG1 mice.
keywords: atrx; brain; cko; control; expression; figure; gene; learning; male; memory; mice; neurons; synaptic
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item: #45 of 104
id: cord-104251-cq8ojfit
author: None
title: In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
date: 1981-03-01
words: 2140
flesch: 53
summary: Following the above findings, macrophage cultures from HC-treated mice receiving 104 LDs0 of MHV(PRI), and which were destroyed by the virus, were assayed for virus yield on CzH and C3Hss macrophages on days 5 and 7 postinfection. Willenborg (7), using a single dose of 2.5 mg cortisone, had found that the LDs0 of MHV(PRI) virus in macrophage cultures from cortisone-treated Call mice was 103.4 , and in cultures from untreated mice, it was 103.2 .
keywords: cells; macrophages; mice; virus
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item: #46 of 104
id: cord-253459-tcn10pho
author: Moreau, Gregory Brett
title: Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection
date: 2020-07-28
words: 2395
flesch: 50
summary: The major histopathology findings in infected mice were proteinaceous debris in the alveolar space, neutrophils in the interstitial space, and alveolar septal thickening ( Figure 2 ); these observations were consistent with other hACE2 mouse models, which also detected signs of lung injury including interstitial pneumonia, inflammatory cell infiltrates, and alveolar septal thickening. Our findings are consistent with other studies using hACE2 mice, which observed successful infection with SARS-CoV-2 and a milder disease severity compared with SARS-CoV-1.
keywords: cov-2; hace2; infection; mice; mouse; sars
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item: #47 of 104
id: cord-254155-860780z9
author: Wang, Junyi
title: The ACE2‐deficient mouse: A model for a cytokine storm‐driven inflammation
date: 2020-06-17
words: 4795
flesch: 45
summary: Immortalized corneal epithelial cells, hTCEpi, were cultured in keratinocyte serum-free media (Thermo Fisher Scientific, Waltham, MA, USA) as described before. To explore whether such an increase in cytokine expression in corneal epithelial cells enhanced recruitment of immune cells, we conducted trans-well chemotaxis assays using a modified Boyden chamber co-cultured with the RAW-Dual macrophage cell line against hTCEpi cells on the bottom chamber.
keywords: ace2; angii; angiotensin; cells; corneal; cytokine; epithelium; expression; figure; inflammation; inflammatory; mice; −/−
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item: #48 of 104
id: cord-254190-bxfne94u
author: Tu, Wenwei
title: Application of Humanized Mice in Immunological Research
date: 2015-07-07
words: 6266
flesch: 17
summary: Scientists are still improving the humanized mouse model but are optimistic about its future role in evaluating AIDS vaccine candidates Humanized mice as a preclinical tool for infectious disease and biomedical research HLA transgenic mice as humanized mouse models of disease and immunity Prevention of Humanized diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A*0201 Humanized mice for studying human leukocyte integrins in vivo Full reconstitution of human platelets in humanized mice after macrophage depletion Human T cell development in the liver of humanized NOD/SCID/ IL-2Rgamma(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/ liver tissue and hematopoietic stem cells Expression of HLA class II molecules in humanized NOD. Rapid evolution of HIV-1 to functional CD8(+) T cell responses in humanized BLT mice Effi cient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2(-)/(-) gamma C(-)/(-) mice in vivo Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads Engineering HIV-1-resistant T-cells from short-hairpin RNAexpressing hematopoietic stem/progenitor cells in humanized BLT mice An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice Intravital microscopy in BLT-humanized mice to study cellular dynamics in HIV infection Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice Humanized mice for modeling human infectious disease: challenges, progress, and outlook Mosquito bite delivery of dengue virus enhances immunogenicity and pathogenesis in humanized mice Utility of humanized BLT mice for analysis of dengue virus infection and antiviral drug testing Enhanced humoral and HLA-A2-restricted dengue virus-specifi c T-cell responses in humanized BLT NSG mice Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice Dengue virus tropism in humanized mice recapitulates human dengue fever EBNA3B-defi cient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice Epstein-Barr virus induces erosive arthritis in humanized mice T cells modulate Epstein-Barr virus latency phenotypes during infection of humanized mice Reproduction of Epstein-Barr virus infection and pathogenesis in humanized mice Adoptive transfer of EBV Specifi c CD8+ T cell clones can transiently control EBV infection in humanized mice HCMV infection of humanized mice after transplantation of G-CSF-mobilized peripheral blood stem cells from HCMV-seropositive donors Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection Humanized mice for Salmonella typhi infection: new tools for an old problem Modeling of human herpesvirus infections in humanized mice Human herpesvirus 6A infection and immunopathogenesis in humanized Rag2(-)/(-) gammac(-)/(-) mice Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria Humanized mice, a new model to study the infl uence of drug treatment on neonatal sepsis Humanized mice for the study of infectious diseases Development of a transgenic mouse model susceptible to human coronavirus 229E New generation humanized mice for virus research: comparative aspects and future prospects Infectious diseases in humanized mice Use of humanized severe combined immunodeficient mice for human vaccine development Human immune responses and potential for vaccine assessment in humanized mice Broad infl uenza-specifi c CD8+ T-cell responses in humanized mice vaccinated with infl uenza virus vaccines Humanized mice: are we there yet? Humanized mice: current states and perspectives Humanized mice for immune system investigation: progress, promise and challenges This work was supported in part by the Area of Excellence program supported by the University Grants Committee of the Hong Kong SAR, China (AoE/M-12/06 and AoE/M-06/08).
keywords: cells; development; diseases; hla; human; immune; infection; mice; model; mouse; specifi; system; transgenic; virus
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item: #49 of 104
id: cord-254950-y6kayxie
author: Morse, Stephen S.
title: Mouse thymic virus (MTLV; Murid Herpesvirus 3) infection in athymic nude mice: Evidence for a T lymphocyte requirement
date: 1988-03-31
words: 2126
flesch: 48
summary: Nude mice are athymic as a result of a genetic defect which prevents the development of the embryonic thymus (5) . In nude mice (6).
keywords: infection; mice; mouse; mtlv; virus
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item: #50 of 104
id: cord-256903-8lyw27gh
author: Guzman, Efrain
title: Contributions of Farm Animals to Immunology
date: 2018-12-06
words: 6515
flesch: 29
summary: Thymic and extra-thymic development of T cells has been studied mainly in mice and because the expression of CD8 and CD4 in mouse T cells for the most part mutually exclusive, CD4/CD8 DP lymphocytes have generally been ignored. Unlike mice, other species like cattle, pigs and chickens possess a substantial proportion of T cells expressing the γδ TCR cells in the circulation suggesting that circulating γδ TCR T cells have a more important role immunity than previously thought (54) .
keywords: animals; antibody; antigen; bovine; cattle; cells; disease; human; immune; mice; pigs; responses; studies; vaccine; virus
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item: #51 of 104
id: cord-256998-or73in8m
author: Nguyen, Khue G.
title: Localized Interleukin-12 for Cancer Immunotherapy
date: 2020-10-15
words: 27094
flesch: 27
summary: A much larger number of preclinical and clinical studies have used IL-12-transduced tumor cells for s.c. immunization. Tumor IL-12 levels steadily increased, reaching about 80 pg/g tumor on day 16, while serum IL-12 concentration remained on average about 40 pg/ml after day 9 and continued to day 16.
keywords: activity; administration; antitumor; cancer; cells; cytokine; delivery; encoding; expression; gene; growth; human; i.t; il-12; il12; immune; immunity; injection; interleukin-12; intratumoral; levels; melanoma; mice; model; murine; patients; phase; regression; responses; studies; study; systemic; t cells; therapy; treatment; tumor; vector; virus
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item: #52 of 104
id: cord-257167-rz4r5sj7
author: None
title: Abstracts for the 29th Annual Meeting of the Japan Neuroscience Society (Neuroscience2006)
date: 2006-12-31
words: 241480
flesch: 43
summary: Inst., Kyoto Univ., Inuyama, Japan GABAergic cells in the cerebral cortex are divided into subgroups: parvalbumin (PV)-, somatostatin (SOM)-, calretinin (CR)-, and calbindin-containing types. In the present study, we therefore investigated the synthesis of sex steroids and corticosteroids in the hippocampus of adult male rats, by monitoring the metabolism of tritiated steroids with HPLC system. PS2A-G125 GABA depolarizes GnRH neurons isolated from adult GnRH-EGFP transgenic rats Chengzhu Yin, Nobuyuki Tanaka, Masakatsu Kato, Yasuo Sakuma Nippon Medical School, Department of physiology, Tokyo, Japan GnRH neurons are essential in the reproductive neuroendocrine system.
keywords: 1,2; 100; acid; action; activation; activities; activity; addition; administration; adult; age; amplitude; amygdala; analysis; animals; antagonist; application; area; astrocytes; auditory; axons; bdnf; behavioral; binding; biology; body; brain; brain activity; brain development; brain function; brain research; brain science; bsi; ca1; calcium; camkii; cells; cellular; center; central; cerebellar; cerebral; changes; channel; chiba; cns; cognitive; complex; condition; contrast; control; correlation; cortex; cortex neurons; cortical; crest; cultured; current; data; days; death; decrease; dendrites; dendritic; department; dept; development; difference; differentiation; direction; disease; disorders; distribution; div; division; domain; dopamine; dopaminergic; dorsal; dynamics; effect; estrogen; evoked; excitatory; experiments; exposure; expression; eye; factors; family; fibers; field; findings; firing; fmri; following; formation; fos; frequency; function; funds; gaba; gabaergic; gene; gene expression; gfp; glutamate; gnrh neurons; graduate; granule; group; growth; gyrus; hand; health; high; hippocampal neurons; hippocampus; hiroshi; human; imaging; increase; individual; induced; induction; inhibition; inhibitory; injection; injury; inputs; institute; interaction; interneurons; intracellular; involvement; japan; japan brain; japan neural; japan neurons; japan science; jst; kakenhi; kinase; kyoto; kyoto university; lab; laboratory; layer; learning; left; level; life; like; localization; loss; ltd; ltp; male; manner; mechanisms; med; medical; medicine; membrane; memory; method; mice; microglia; migration; model; molecular; molecules; monkeys; motion; motor; motor neurons; mouse; mouse brain; movement; mrna; multiple; muscle; mutant; nagoya; national; nerve; nervous; network; neural; neurite; neuronal; neurons; neuroscience; new; nmda; non; novel; nuclei; nucleus; number; olfactory; onset; order; osaka; osaka university; pain; pathway; patients; pattern; period; phase; phosphorylation; physiology; plasticity; play; postnatal; postsynaptic; potential; prefrontal; presence; present; presynaptic; primary; process; processes; processing; progenitor cells; projection neurons; proliferation; properties; protein; ps2p; ps3a; ps3p; purkinje cells; pyramidal; rat brain; rate; rats; receptor; recorded; recording; reduced; region; regulation; relationship; release; report; required; research; research funds; research institute; response; results; reward; right; riken; role; saitama; school; sciences; second; selective; sensory; signaling; signals; site; size; slices; social; specific; spike; spinal; spines; state; stem cells; stimulation; stimuli; stimulus; stress; structure; studies; study; subjects; surface; synapses; synaptic; system; target; task; technology; temporal; term; terminals; test; time; tohoku; tokyo; tokyo university; transcription; transgenic; transmission; treatment; tsukuba; type; university; university graduate; university school; usa; visual; vitro; vivo; voltage; weeks; wild; zone
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item: #53 of 104
id: cord-258129-c38q6xxs
author: Russell, Clark D
title: The role of pro-resolution lipid mediators in infectious disease
date: 2014-01-09
words: 5146
flesch: 25
summary: In contrast to the control group, mice administered resolvin had lower bronchoalveolar lavage neutrophil counts, higher monocyte/macrophage counts, increased neutrophil apoptosis, reduced bronchoalveolar lavage IL-6 levels and less severe pulmonary inflammation when assessed histologically. Importantly, mice administered resolvin E1 enjoyed increased survival (100% at 3 days, in comparison to 50% when only 0Á9% saline was administered).
keywords: effect; infection; inflammation; lipoxin; mice; model; neutrophil; resolution; resolvin; virus
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item: #54 of 104
id: cord-261036-zdhg4axx
author: Shirato, Kazuya
title: Enhanced cell fusion activity in porcine epidemic diarrhea virus adapted to suckling mice
date: 2010-09-09
words: 3339
flesch: 56
summary: In our study, both mouse-adapted and non-adapted MK strains of PEDV could infect and grow in suckling mouse brains, suggesting that a receptor molecule utilized by both viruses exists in suckling mouse brain. In the present study, we isolated a strain of PEDV that was more virulent than the original tissue-culture-adapted virus after passage through mouse brain cells.
keywords: cells; mice; mouse; p10; pedv; virus
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item: #55 of 104
id: cord-262445-54ng7m92
author: Gabellini, Davide
title: 16th Meeting of the Interuniversity Institute of Myology (IIM) - Assisi (Italy), October 17-20, 2019: Foreword, Program and Abstracts
date: 2020-09-15
words: 19436
flesch: 35
summary: Given the anti-atrophic action of 25-OH-VD, we wondered if also the pro-hormone VD could have a direct activity on skeletal muscle cells. In skeletal muscle cells a specific splice variant of MEF2C, MEF2C α1, activates the increase of skeletal muscle mass by activating the expression of IGF1 and S6K. These activities are repressed by its phosphorylation, that renders it a target for the inhibitory effect of PIN1 on its protein stability and activity.
keywords: activity; atrophy; cachexia; cancer; cells; differentiation; disease; dmd; effects; exercise; expression; function; genes; inflammation; levels; loss; mice; molecular; mouse; muscle; muscle cells; muscle regeneration; muscular; myotubes; patients; process; protein; regeneration; response; results; role; scs; stem; study; tissue; vitro
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item: #56 of 104
id: cord-264408-vk4lt83x
author: Ruiz, Sara I.
title: Animal Models of Human Viral Diseases
date: 2017-06-23
words: 34509
flesch: 38
summary: The severe acute respiratory syndrome severe acute respiratory syndrome Bacterial sinusitis and otitis media following influenza virus infection in ferrets Neuropathology of H5N1 virus infection in ferrets The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease Immunopathogenesis of coronavirus infections: implications for sArs Hantavirus pulmonary syndrome: the new American hemorrhagic fever rift Valley fever Inbred rat strains mimic the disparate human response to rift Valley fever virus infection experimental studies of arenaviral hemorrhagic fevers experimental rift Valley fever in rhesus macaques Bovine respiratory syncytial virus protects cotton rats against human respiratory syncytial virus infection Human Hendra virus encephalitis associated with equine outbreak Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virus structure as revealed by airway dissection. emerg Generation of a transgenic mouse model of Middle east respiratory syndrome coronavirus infection and disease Pathological changes in brain and other target organs of infant and weanling mice after infection with nonneuroadapted Western equine encephalitis virus Particle-to-PFU ratio of ebola virus influences disease course and survival in cynomolgus macaques Progress toward norovirus vaccines: considerations for further development and implementation in potential target populations Characterization of lethal Zika virus infection in AG129 mice experimental in vitro and in vivo models for the study of human hepatitis B virus infection A model of meningococcal bacteremia after respiratory superinfection in influenza A virus-infected mice Middle east respiratory syndrome coronavirus: current situation and travel-associated concerns Aerosol exposure to the Angola strain of marburg virus causes lethal viral hemorrhagic fever in cynomolgus macaques Necrotizing scleritis, conjunctivitis, and other pathologic findings in the left eye and brain of an ebola Virus-Infected rhesus macaque (Macaca mulatta) with apparent recovery and a delayed time of death American Academy of Pediatrics subcommittee on Diagnosis and Management of Bronchiolitis Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models The gerbil, Meriones unguiculatus, a model for rift Valley fever viral encephalitis Morbidity and mortality among patients with respiratory syncytial virus infection: a 2-year retrospective review Chikungunya and the nervous system: what we do and do not know The West Nile virus outbreak of 1999 in New York: the Flushing Hospital experience Hospital outbreak of Middle east respiratory syndrome coronavirus Diagnosis of noncultivatable gastroenteritis viruses, the human caliciviruses Norovirus vaccine against experimental human Norwalk Virus illness Determination of the 50% human infectious dose for Norwalk virus An epizootic attributable to Western equine encephalitis virus infection in emus in Texas evidence for camel-to-human transmission of Mers coronavirus Integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted rag2 −/− gamma c
keywords: acute; aerosol; animal; animal model; cells; challenge; clinical; coronavirus; cov; cynomolgus; days; dengue; disease; encephalitis; et al; experimental; exposure; ferrets; fever; fever virus; guinea; hepatitis; human; infected; infection; infection model; influenza; influenza virus; inoculation; lethal; liver; macaques; mice; model; monkeys; mouse; mouse model; nhps; pathogenesis; pigs; replication; response; rhesus; route; sars; signs; strain; studies; study; symptoms; syndrome; transmission; vaccine; viral; viremia; virus; virus infection; viruses
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item: #57 of 104
id: cord-265299-oovkoiyj
author: Hickman, D.L.
title: Commonly Used Animal Models
date: 2016-11-25
words: 14970
flesch: 49
summary: Throughout history, outbreaks of bubonic plague, typhus, and hantaviruses have had an unwitting accomplice in the rat (Zinsser, 1935; Benedictow, 2004; Firth et al., 2014) . Over the centuries, rats have also been used for food (e.g., in Imperial China), companionship, and sport (Gorn and Goldstein, 2004; Hopkins et al., 2004; Burt, 2006) .
keywords: amphibians; animals; behavior; birds; body; cage; care; couto; development; disease; enrichment; et al; example; female; fig; food; glands; housing; laboratory; male; mice; model; mouse; rabbits; rats; reptiles; research; rodents; sohn; species; studies; system; water; zebrafish
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item: #58 of 104
id: cord-265847-oq34lc26
author: Yagami, K.
title: Pathogenesis of haemagglutinating encephalomyelitis virus (HEV) in mice experimentally infected by different routes
date: 1986-11-30
words: 3350
flesch: 57
summary: We have demonstrated the growth of the 67N strain of HEV in suckling mouse brain following i.c. inoculation. Furthermore, the olfactory nerve may also serve as one of the pathways to the CNS in i.n. inoculated mice.
keywords: i.c; inoculation; mb-67n; mice; strain; suckling; virus
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item: #59 of 104
id: cord-266745-jit1xeqc
author: Liou, Jenn-Fa
title: Passive protection effect of chicken egg yolk immunoglobulins on enterovirus 71 infected mice
date: 2010-11-29
words: 5726
flesch: 49
summary: The mortality among specific IgY treated mice was 24% (10/41), which was significantly lower than that of the control group, at 69% (33/48). In 1998, an outbreak of EV71 infections occurred in Taiwan, in which 405 children were hospitalized and 78 died [15] .
keywords: anti; egg; enterovirus; ev71; igy; infection; mice; neutralization; specific; treatment; yolk
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item: #60 of 104
id: cord-267482-afqfymbq
author: Ryu, Seungjin
title: Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model
date: 2020-09-12
words: 8214
flesch: 40
summary: For example, epithelial cell specific induction of hACE2 (K18-hACE2) as a model of SARS-CoV-2 infection demonstrated that post intranasal inoculation, animals develop lung inflammation and pneumonia driven by infiltration of monocytes, neutrophils and T cells . Interestingly, some of the most striking changes occurred in T cells, where ketogenesis led to a substantial increase in ϒδ but not αβ T cells ( Figure 6C and Figure S6B ).
keywords: a59; aging; cells; cov-2; covid-19; et al; expression; figure; infection; inflammasome; inflammation; mcov; mice; model; mouse; nlrp3; sars; ϒδ t
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item: #61 of 104
id: cord-267671-ys43n672
author: Whary, Mark T.
title: Biology and Diseases of Mice
date: 2015-07-10
words: 63704
flesch: 37
summary: If an endogenous retrovirus is still infectious to other mouse cell targets, it is termed ecotropic, whereas if it is no longer infectious for mouse cells, but can infect cells of other species, it is termed xenotropic. Recombinant viruses have recently been discovered that can infect mouse cells and heterologous cells and are associated with spontaneous leukemia development in high leukemia strains such as AKR mice.
keywords: acute; adult mice; age; animal; bacterial; blood; breeding; c mice; c57bl/6 mice; cause; cells; chronic; clinical; colonies; common; complications; control; days; detection; development; diagnosis; differential; difficile; disease; eggs; epithelium; epizootiology; et al; etiology; feces; female; fig; gene; genome; hair; helicobacter; hepaticus; high; host; humans; hyperplasia; immune; immunity; immunodeficient mice; infant mice; infection; inflammation; inoculation; intestine; laboratory mice; lesions; lines; liver; lymph; male; medicine; mhv; mice; mouse; mouse colonies; mouse strains; murine; necrosis; organisms; pathology; pcr; potential; prevention; primary; rats; research; responses; results; scid; signs; skin; species; specific; spleen; strains; studies; susceptibility; system; tissues; tract; transmission; treatment; tumors; type; virus; virus infection; viruses; weeks
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item: #62 of 104
id: cord-267965-84sotgds
author: Noll, Kelsey E.
title: The Collaborative Cross: A Systems Genetics Resource for Studying Host-Pathogen Interactions
date: 2019-04-10
words: 9374
flesch: 28
summary: Kri sti c et al. studied variation in IgG glycosylation, which is important for antibody structure and function, in 95 CC strains and observed nearly double the variation observed in humans (Kri sti c et al., 2018) . Differential gene expression analysis at days 2 and 4 post SARS-CoV or IAV infection showed significant differences driven by mouse strain, infection status, and time point.
keywords: analysis; disease; et al; gene; host; infection; mapping; mice; mouse; pathogen; phenotypes; population; qtl; response; strains; studies; study; susceptibility; variation
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item: #63 of 104
id: cord-278136-ol2buwld
author: Gonzales, Natalia M.
title: 29th International Mammalian Genome Conference meeting report
date: 2016-05-02
words: 4689
flesch: 31
summary: Alterations to the Seok et al. (2013) analysis included comparing genes that exist in both mouse and human, not just human disease genes that lack rodent homologs. The impact of mouse models on precision oncology was showcased by Carol Bult (O-01; The Jackson Laboratory), who discussed how patient-derived xenograft models can provide a platform for testing therapeutic options to guide treatments for breast and other cancers (Fig. 2) .
keywords: analysis; cell; data; disease; expression; gene; genetics; genome; human; institute; meeting; models; mouse; research; riken; session; university
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item: #64 of 104
id: cord-281161-u896icp9
author: Wang, Jing
title: The Adjuvanticity of an O. volvulus-Derived rOv-ASP-1 Protein in Mice Using Sequential Vaccinations and in Non-Human Primates
date: 2012-05-17
words: 6880
flesch: 41
summary: A number of microbial products, including bacterial LPS, peptidoglycan, dsRNA, muramyl peptides, CpG, flagellin and microbial proteins, were shown to act as vaccine adjuvants [41] [42] Alum's adjuvant action: grease is the word Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity Immunological mechanisms of vaccination Vaccine adjuvants: putting innate immunity to work Adjuvants for the future Recent advances in vaccine adjuvants Rationally-designed vaccine adjuvants: separating efficacy from toxicity Enhancing oral vaccine potency by targeting intestinal M cells Diversity and dialogue in immunity to helminths Immune regulation by helminth parasites: cellular and molecular mechanisms T helper type-2 cytokine responses: potential therapeutic targets Helminth antigens modulate TLR-initiated dendritic cell activation TLR11 activation of dendritic cells by a protozoan profilin-like protein rOv-ASP-1, a recombinant secreted protein of the helminth Onchocerca volvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypeptide and SARS-CoV peptide antigens Immune evasion genes from filarial nematodes Helminth parasites-masters of regulation A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62 ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential Modulation of a heterologous immune response by the products of Ascaris suum Taenia crassiceps carbohydrates stimulate IL-6 expression in naive murine macrophages via Toll-like receptors (TLRs)
keywords: adjuvant; antibodies; antibody; asp-1; cpg; mice; protein; responses; rov; rrbd; sars; th1; th2; vaccine
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item: #65 of 104
id: cord-281410-y558a5jf
author: Akashi, H.
title: Propagation of the Kakegawa strain of bovine coronavirus in suckling mice, rats and hamsters
date: 1981
words: 1124
flesch: 54
summary: (4) reported that they had adapted the American strain of calf diarrhea coronavirus to suckling mouse brain. The Kakegawa strain of BCV used for mouse inoculation was at, the 10th passage level in primary bovine kidney cell cultures.
keywords: coronavirus; hamsters; mice; strain
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item: #66 of 104
id: cord-287527-ep6ug9c3
author: Algaissi, Abdullah
title: Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease
date: 2018-09-26
words: 4734
flesch: 43
summary: Tg mice, was developed through mating of hDPP4 +/− mice and used as breeders for generating offspring of both genotypes of hDPP4 Tg mice. ELISA-based and Vero E6 cell-based microneutralization assays, previously described [7] , were used to determine the titers of MERS-CoV RBD-specific serum IgG and neutralizing antibodies in hDPP4 Tg mice in response to MERS-CoV infection.
keywords: cov; hdpp4; infection; mers; mice; rshdpp4
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item: #67 of 104
id: cord-287670-z6ckhkgg
author: Magrini, Elena
title: The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?
date: 2016-06-30
words: 8288
flesch: 28
summary: Accordingly, in acute and chronic models of P. aeruginosa lung infection in mice PTX3 has exhibited therapeutic outcomes such as reduced bacterial burden and inflammation [47, 48] . Based on the primary structure of the protomer, pentraxins have been divided into short pentraxins, including CRP and SAP, and long pentraxins, such as the prototype long pentraxin PTX3 [4] .
keywords: activation; cancer; cells; complement; damage; expression; human; immunity; infection; inflammation; mice; pentraxin; protein; ptx3; recognition; role; tissue
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item: #68 of 104
id: cord-288133-h3wmo0xj
author: Hickman, Debra L
title: Evaluation of the neutrophil:lymphocyte ratio as an indicator of chronic distress in the laboratory mouse
date: 2017-06-23
words: 3761
flesch: 51
summary: These stress events have consistently been associated with elevations in mouse serum and fecal corticosterone 6, 11, 12 and neuropeptides 13 . key: cord-288133-h3wmo0xj authors: Hickman, Debra L title: Evaluation of the neutrophil:lymphocyte ratio as an indicator of chronic distress in the laboratory mouse date: 2017-06-23 journal: Lab Anim (NY) DOI: 10.1038/laban.1298 sha: doc_id: 288133 cord_uid: h3wmo0xj When evaluating the effect of husbandry and biomethodologies on the well-being of laboratory mice, it is critical to utilize measurements that allow the distinguishing of acute stress from chronic stress.
keywords: animal; chronic; corticosterone; mice; mouse; ratio; serum; stress
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item: #69 of 104
id: cord-288253-wqrhiq08
author: Park, Jung-Eun
title: Development of transgenic mouse model expressing porcine aminopeptidase N and its susceptibility to porcine epidemic diarrhea virus
date: 2015-02-02
words: 5336
flesch: 42
summary: We thus generated porcine APN transgenic mice expressing porcine APN in the brush borders of their small intestines and various tissues (lungs and kidneys). PEDV replication in the small intestines of porcine APN transgenic mice Both wild type and porcine APN transgenic mice were infected with PEDV orally on day 0.
keywords: anti; apn; cells; coronavirus; et al; mice; mouse; pcr; pedv; porcine; porcine apn; transgenic
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item: #70 of 104
id: cord-292157-hrm69640
author: Stull-Lane, Annica R.
title: Vitamin A supplementation boosts control of antibiotic-resistant Salmonella infection in malnourished mice
date: 2020-10-02
words: 5923
flesch: 43
summary: Control mice and one group of VAD mice were mock-treated with PBS. Control mice were mock-treated with PBS, one group of VAD mice was treated with vitamin A as previously described and a second group of VAD mice received mock-treatment.
keywords: antibiotic; control; enrofloxacin; fig; infection; male; mice; treatment; typhimurium; vad; vitamin
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item: #71 of 104
id: cord-292402-u3sfc1yz
author: Watanabe, Rihito
title: Formation of fibroblastic reticular network in the brain after infection with neurovirulent murine coronavirus
date: 2016-04-28
words: 6985
flesch: 45
summary: In spite of these findings, it is not plausible that the ERag produced by brain parenchymal cells was directly employed in the conduit system to guide the invasions of the virus or inflammatory cells, as indicated in the meninges and ventricle, because the viral antigens and inflammatory cell invasions were not observed at 48 hpi in the large area where they were produced by brain parenchymal cells. Therefore, local immune reactions relevant to brain pathology should be further examined, especially on cross-talk between brain parenchymal cells, 63 possibly after receiving information from the conduit around the PaBv.
keywords: area; brain; cells; erag; erfibs; fig; hpi; infected; infection; laminin; mice; ventricle
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item: #72 of 104
id: cord-292596-ulu5y140
author: Lee, Su Hae
title: Characterization of changes in global gene expression in the hearts and kidneys of transgenic mice overexpressing human angiotensin-converting enzyme 2
date: 2020-07-29
words: 5980
flesch: 44
summary: Especially, it has been reported that ACE2 gene expression is upregulated in humans with heart failure [13] . A first step in understanding SARS pathogenesis Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies Age-and gender-related difference of ACE2 expression in rat lung Myocardial infarction increases ACE2 expression in rat and humans ACE2 gene expression is upregulated in the human failing heart Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensinconverting enzyme: implications for albuminuria in diabetes Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II ACE and ACE2: their role to balance the expression of angiotensin II and angiotensin Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats
keywords: angiotensin; dox; dtg; expression; genes; hace2; heart; kidney; mhc; mice; non; protein; rtta
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item: #73 of 104
id: cord-295194-xbla6tu7
author: Stripecke, Renata
title: Innovations, challenges, and minimal information for standardization of humanized mice
date: 2020-06-24
words: 9908
flesch: 28
summary: Humanized mouse models result from the sum of several components: choice and availability of human donors, human cells or tissues, mouse recipient, types of manipulations, human infections, and human tumor types. Suppression of tumor growth with pembrolizumab only occurred in mice co-engrafted with human immune cells and the response was abrogated when mice were pretreated with anti-human CD8 mAb to deplete human CD8 + T cells, demonstrating human CD8 + T cells mediated the effector response following release from checkpoint inhibition.
keywords: cancer; cells; development; engraftment; et al; hiv; human; immune; infection; liver; mice; models; mouse; pdx; responses; specific; stem; studies; tissues; tumor; virus
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item: #74 of 104
id: cord-298117-9ycl7mn6
author: Monk, Caroline
title: Ocular Surface Disease in Rodents (Guinea Pigs, Mice, Rats, Chinchillas)
date: 2018-11-17
words: 3276
flesch: 46
summary: key: cord-298117-9ycl7mn6 authors: Monk, Caroline title: Ocular Surface Disease in Rodents (Guinea Pigs, Mice, Rats, Chinchillas) date: 2018-11-17 journal: Vet Clin North Am Exot Anim Pract DOI: 10.1016/j.cvex.2018.08.001 sha: doc_id: 298117 cord_uid: 9ycl7mn6 This article discusses the clinical appearance, differential diagnoses, and treatment considerations of corneal disease in the most common domesticated species of rodent: mouse, rat, chinchilla, and guinea pig. Many corneal diseases are related to inbred strains of either research or pet rodents.
keywords: chinchillas; disease; guinea; mice; pigs; rats; size; species; treatment
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item: #75 of 104
id: cord-299605-j1ewxk4q
author: Lin, Jing-wen
title: Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria
date: 2017-02-03
words: 6678
flesch: 43
summary: AS and CB infected mice showed comparable iRBC loads (parasitemia multiplied by total RBC numbers), despite the fact that higher peak The total numbers of infected red blood cells (iRBC) per ml of blood (b) and the parasitemia (percentage of infected iRBC) (c) in the mice infected with AS or CB parasites. Moreover, the RBC loss in CB infected mice is longer lasting, even after the peak of infection at 12 dpi (Fig. 1d,e) .
keywords: analysis; blood; chabaudi; dpi; fig; genes; infected; infection; lungs; malaria; mice; naïve; transcripts
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item: #76 of 104
id: cord-300372-h5g4z8ts
author: Kelvin, Alyson A.
title: Lack of Group X Secreted Phospholipase A(2) Increases Survival Following Pandemic H1N1 Influenza Infection
date: 2014-04-01
words: 10499
flesch: 42
summary: In the first series of infections, GX þ / þ (n¼25), GX þ /-(n¼32), and GX À /À (n¼24) mice on a C57BL/6J background were infected intranasally with H1N1pdm influenza A/Mexico/4108/2009 ( Fig. 2A ). The difference in survival between GX À /À and GX þ /mice, and between GX À /À and GX þ / þ mice after H1N1pdm infection was statistically significant, pr0.01.
keywords: cell; day; days; et al; expression; fig; genes; gx þ; h1n1pdm; infection; influenza; lung; spla; time; þ mice
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item: #77 of 104
id: cord-303662-ro9879dl
author: Wang, Fun-In
title: Demyelination induced by murine hepatitis virus JHM strain (MHV-4) is immunologically mediated
date: 1990-11-30
words: 3803
flesch: 41
summary: In each group, 5 x 10 v spleen cells were transferred i.v. into recipient mice on day 6 p.i. b Recipient mice were 6-week-old C57BL/6J male inoculated (Virus) or not (Naive) with 103 PFU of JHMV 2.2-V-1 i.c. on day 0. in Table 1 , mice were infected with a second JHMV strain, JHMV-DS (Stohlman et al., 1982) , and were either irradiated or not irradiated.
keywords: cells; day; demyelination; disease; jhmv; mice; virus
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item: #78 of 104
id: cord-304855-7v0cncid
author: Raaben, Matthijs
title: Non‐invasive imaging of mouse hepatitis coronavirus infection reveals determinants of viral replication and spread in vivo
date: 2009-02-10
words: 8405
flesch: 44
summary: As the inoculation route largely determines the dissemination of virus infection in an animal, we made use of both intranasal and intraperitoneal injection. In mice that received the low dose virus replication was initially restricted to the nasal cavity, while much faster dissemination of virus infection was observed after inoculation with a high dose.
keywords: bli; days; dissemination; dose; et al; infection; inoculation; mhv; mice; mouse; replication; type; virus
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item: #79 of 104
id: cord-306516-5t3ix35e
author: Li, Minghui
title: Dual roles of calpain in facilitating Coxsackievirus B3 replication and prompting inflammation in acute myocarditis
date: 2016-10-15
words: 3766
flesch: 48
summary: Calpain activity is regulated by the endogenous inhibitor, calpastatin. Calpastatin is an intracellular 110-kDa protein that inhibits calpain activity specifically.
keywords: calpain; cells; cvb3; fig; inflammation; inhibition; mouse; myocarditis; replication; transgenic; virus
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item: #80 of 104
id: cord-306535-j26eqmxt
author: Robertson, Matthew J.
title: Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets
date: 2020-08-19
words: 16775
flesch: 43
summary: [28] to create a comprehensive database of mouse gene symbols orthologous to human genes and vice versa. The majority of identified genes were not from a traditional drug target family like kinases or enzymes.
keywords: analysis; candidate genes; cell; ces5a; datasets; epididymis; expression; fig; file; genes; human; male; mice; mouse; mouse genes; number; protein; reproductive; rna; samples; seq; specific; sperm; spint3; studies; table; testis; tissue; tract
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item: #81 of 104
id: cord-308461-4lhh3du0
author: Ueki, Hiroshi
title: Multicolor two-photon imaging of in vivo cellular pathophysiology upon influenza virus infection using the two-photon IMPRESS
date: 2020-01-29
words: 8359
flesch: 35
summary: The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors T cell response in the lung following influenza virus infection Neutrophil trails guide influenza-specific CD8 + T cells in the airways Live imaging of influenza infection of the trachea reveals dynamic regulation of CD8 + T cell motility by antigen Imaging cell interaction in tracheal mucosa during influenza virus infection using two-photon intravital microscopy Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies Molecular determinants of virulence and stability of a reporter-expressing H5N1 influenza A virus Amino acid changes in PB2 and HA affect the growth of a recombinant influenza virus expressing a fluorescent reporter protein Live imaging of the lung A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre ransgene transmission Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes A multifunctional teal-fluorescent Rosa26 reporter mouse line for Cre-and Flp-mediated recombination TrackMate: an open and extensible platform for single-particle tracking The role of neutrophils during mild and severe influenza virus infections of mice Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis The effects of acute neutrophil depletion on resolution of acute influenza infection, establishment of tissue resident memory (TRM), and heterosubtypic immunity Antibodies against neutrophil LY6G do not inhibit leukocyte recruitment in mice in vivo Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanism Spectral imaging: principles and applications Multispectral imaging in biology and medicine: slices of life A robust and high-throughput Cre reporting and characterization system for the whole mouse brain Regulating the adaptive immune response to respiratory virus infection A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection Innate immunity to influenza virus infection Intravascular staining for discrimination of vascular and tissue leukocytes In vivo compartmental analysis of leukocytes in mouse lungs A study of the pulmonary circulation by the transillumination method Pulmonary capillary recruitment during airway hypoxia in the dog The behavior of the arterioles and capillaries of the lung Capillary recruitment during airway hypoxia: role of pulmonary artery pressure Capillaroscopic appearance of the pulmonary alveoli in the living dog Diffusing capacity of the lung during hypoxia: role of capillary recruitment Intrapulmonary blood flow redistribution during hypoxia increases gas exchange surface area The normal behavior of the pulmonary blood vessels with observations on the intermittence of the flow of blood in the arterioles and capillaries An experimental model for simultaneous quantitative analysis of pulmonary micro-and macrocirculation during unilateral hypoxia in vivo A thoracic window for observation of the lung in a living animal Microscopic observation of the lung in vivo Precapillary oxygenation contributes relevantly to gas exchange in the intact lung Pulmonary microcirculatory observations in vivo under physiological conditions Direct measurement of pulmonary capillary transit times Intravital laser confocal microscopy of pulmonary edema resulting from intestinal ischemia-reperfusion injury in the rat Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries Measurement of lung microvascular pressure in the intact anesthetized rabbit by the micropuncture technique Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance Capillary perfusion patterns in single alveolar walls Measurement of microhemodynamics in the ventilated rabbit lung by intravital fluorescence microscopy Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction Leukocyte kinetics in pulmonary microcirculation: intravital fluorescence microscopic study The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis Temporal capillary perfusion patterns in single alveolar walls of intact dogs Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice Sites of leukocyte sequestration in the pulmonary microcirculation CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses Contribution of selectins to leucocyte sequestration in pulmonary microvessels by intravital microscopy in rabbits Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli Leukocyte margination in alveolar capillaries: interrelationship with functional capillary geometry and microhemodynamics Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury
keywords: cells; concentration; excitation; fig; fluorescent; imaging; influenza; laser; lung; mice; mouse; photon; pulmonary; solution; suction; system; virus; vivo; window
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item: #82 of 104
id: cord-312305-ll29frwc
author: Sun, Shihui
title: Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2
date: 2020-11-11
words: 4757
flesch: 44
summary: Additionally, immunostaining of lung sections showed a significant infiltration of CD68 + macrophages and Ly-6G + neutrophils in MASCp36 infected mice ( fig. Aged mice challenged with high dose of MASCp36 developed typical respiratory symptoms and exhibited features like ruffled fur, hunched back, and reduced activity.
keywords: binding; complex; cov-2; covid-19; disease; fig; lung; mace2; mascp36; mice; model; mouse; rbdmascp36; sars
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item: #83 of 104
id: cord-312692-jv3425w1
author: Iwata-Yoshikawa, Naoko
title: Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus
date: 2019-01-09
words: 8569
flesch: 50
summary: When we asked why the Tg2 mice showed nonlethal responses to infection, we could not ignore the fact that virus levels in lungs were lower than those reported for other MERS mouse models (5, 12, 13, 38, 39) . (C) Genomic DNA was extracted from Tg2 mice, and human DPP4 exons 1 to 26 were subjected to PCR using specific primers.
keywords: cells; cov; days; fig; hdpp4; human; infection; lungs; mers; mice; model; mouse; p.i; syndrome; tg2; week
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item: #84 of 104
id: cord-314333-hkyiy1gm
author: Nagata, Noriyo
title: Mouse-Passaged Severe Acute Respiratory Syndrome-Associated Coronavirus Leads to Lethal Pulmonary Edema and Diffuse Alveolar Damage in Adult but Not Young Mice
date: 2008-06-30
words: 6935
flesch: 45
summary: However, intraperitoneal interferon-γ injection protected adult mice from the lethal respiratory illness. These results demonstrated that serial in vivo passage of SARS-CoV in mice increased the virulence of the virus, especially in adult mice.
keywords: adult; adult mice; cov; day; days; infection; inoculation; lung; mice; musx; sars; veroe6; virus
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item: #85 of 104
id: cord-319933-yp9ofhi8
author: Ruiz, Sara I.
title: Chapter 38 Animal Models of Human Viral Diseases
date: 2013-12-31
words: 28862
flesch: 41
summary: Wild-type C57BL/6 adult mice are not permissive to chikungunya virus infection by intradermal inoculation. [Comparative Study Research Support Characterization of clinical and immune response in a rotavirus diarrhea model in suckling Lewis rats Development of a heterologous model in germfree suckling rats for studies of rotavirus diarrhea Studies of oral rehydration solutions in animal models Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model Developmental immunity in the piglet Swine in biomedical research Neonatal calf diarrhea induced by rotavirus Characterisation of the primary local and systemic immune response in gnotobiotic lambs against rotavirus infection Experimental infection of non-human primates with a human rotavirus isolate Development of a rotavirus-shedding model in rhesus macaques, using a homologous wild-type rotavirus of a new P genotype Reflections on 30 years of AIDS HIVs and their replication The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice Hematopoietic stem cell-engrafted NOD/ SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses HIV-1 infection and CD4 T cell depletion in the humanized Rag2�/� gamma c�/� (RAG-hu) mouse model HIV-1 infection and pathogenesis in a novel humanized mouse model Induction of robust cellular and humoral virusspecific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(þ) T cell decline in humanized mice Mucosal immunity and vaccines Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1 Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus Limited dissemination of pathogenic SIV after vaginal challenge of rhesus monkeys immunized with a live Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase SIV-induced impairment of neurovascular repair: a potential role for VEGF Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques A Nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcgammaRIIIamediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys Update on animal models for HIV research Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission Vpx is Critical for SIVmne infection of pigtail macaques Impact of short-term HAART initiated during the chronic stage or shortly post-exposure on SIV infection of male genital organs The rhesus macaque pediatric SIV infection modeld a valuable tool in understanding infant HIV-1 pathogenesis and for designing pediatric HIV-1 prevention strategies Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina Immune and genetic correlates of vaccine protection against mucosal infection by SIV in monkeys Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): a double-blind, randomised, placebo-controlled, test-of-concept trial Human papillomavirus in cervical cancer Human papillomavirus research: do we still need animal models? Animal models of papillomavirus pathogenesis Evidence of human papillomavirus vaccine effectiveness in reducing genital warts: an analysis of California public family planning administrative claims data The rabbit viral skin papillomas and carcinomas: a model for the immunogenetics of HPV-associated carcinogenesis Protection of beagle dogs from mucosal challenge with canine oral papillomavirus by immunization with recombinant adenoviruses expressing codon-optimized early genes Naturally occurring, nonregressing canine oral papillomavirus infection: host immunity, virus characterization, and experimental infection Regression of canine oral papillomas is associated with infiltration of CD4þ and CD8þ lymphocytes Characterization and experimental transmission of an oncogenic papillomavirus in female macaques A multimeric L2 vaccine for prevention of animal papillomavirus infections Preclinical development of highly effective and safe DNA vaccines directed against HPV 16 E6 and E7 US doctors investigate more than 50 possible cases of monkeypox Isolation of monkeypox virus from wild squirrel infected in nature Reemergence of monkeypox: prevalence, diagnostics, and countermeasures Human monkeypox infection: a family cluster in the midwestern United States Human monkeypox and other poxvirus infections of man The confirmation and maintenance of smallpox eradication Human monkeypox Identification of wild-derived inbred mouse strains highly susceptible to monkeypox virus infection for use as small animal models A prairie dog animal model of systemic orthopoxvirus disease using west African and Congo Basin strains of monkeypox virus Comparison of monkeypox viruses pathogenesis in mice by in vivo imaging Comparative pathology of North American and central African strains of monkeypox virus in a ground squirrel model of the disease Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus A mouse model of lethal infection for evaluating prophylactics and therapeutics against monkeypox virus Experimental infection of ground squirrels (Spermophilus tridecemlineatus) with monkeypox virus Experimental infection of prairie dogs with monkeypox virus Experimental infection of cynomolgus macaques (Macaca fascicularis) with aerosolized monkeypox virus The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis) Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus Virulence and pathophysiology of the Congo Basin and west African strains of monkeypox virus in non-human primates
keywords: acute; animal; animal models; challenge; cynomolgus; days; dengue; develop; disease; encephalitis; encephalitis virus; experimental; fever; hepatitis; human; infected; infection; influenza; inoculation; liver; macaques; mice; model; monkeys; mortality; mouse; nhps; pathogenesis; pigs; rhesus; route; sars; signs; strains; studies; study; symptoms; transmission; vaccine; viral; viremia; virus; virus infection; viruses
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item: #86 of 104
id: cord-320172-qw47pf9r
author: Greaves, Peter
title: VII Digestive System 1
date: 2000-12-31
words: 47447
flesch: 33
summary: It has been suggested from studies of the effects of anticancer compounds on neoplastic colonic cells that intestinal cells may possess inherent protective properties in the form of an accelerated efflux pump which can serve to protect them from potentially damaging agents (Klohs and Steinkampf, 1986) . A histochemical study Role of intestinal metaplasia in the histogenesis of gastric carcinoma Colorectal mucin histochemistry in health and disease: A critical review Uptake of particulate and soluble antigens in the small intestines of the rat Chemical colitis due to endoscopic cleaning solutions: A mimic of pseudomembranous colitis Pathology of Domestic Animals Intestinal accumulation of urea in germ-free animals: A factor in caecal enlargement Digestive enzymes in the parotid and submandibular glands of mammals Morphologishe Veränderungen der Magenmukosa von Ratten nach chronischer Antazidagabe Enteric viruses of non human primates Increased accumulation of sulfated glycoaminoglycans in cultures of human fibroblasts from phenytoin-induced gingival overgrowth New insights into the stem cells and the precursors of gastric epithelium Colonic lymphoid-glandular complex (microbursa): Nature and morphology Lymphoid tissue and lymphoid-glandular complexes of the colon: Relation to diverticulosis Histology of salivary gland infarction in the dog Adrenergic factors involved in the control of crypt cell proliferation in jejunum and descending colon of mouse Pill esophagitis Immunogold localization of ingested kidney bean (Phaseolus vugaris) lectins in epithelial cells of the rat small intestine Epithelial dysplasia of the rabbit colon induced by degraded carrageenan Hyperkeratinization and hyperplasia of the forestomach epithelium in vitamin A deficient rats Intrinsic resistance of colon tumors to anthrapyrazoles and antracyclines may be linked with a detoxification mechanism of intestinal cells (Abstract No. 1040)
keywords: acid; activity; administration; agents; animals; cells; changes; chronic; colon; colonic; crypt; damage; differences; disease; dogs; drugs; effects; epithelium; et al; factor; features; forestomach; form; gastric; gastric mucosa; gastrointestinal; glands; glandular; goblet cells; growth; high; human; hyperplasia; increase; inflammation; inflammatory; intestine; laboratory; lesions; lymphocytes; lymphoid; man; metaplasia; mice; mouse; mucins; mucosa; non; number; oral; presence; rats; result; rodents; salivary; secretion; species; stomach; studies; study; surface; tissue; tract; treatment; ulceration; ulcers
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item: #87 of 104
id: cord-324326-q014b5ym
author: MURAKAMI, Makoto
title: Lipoquality control by phospholipase A(2) enzymes
date: 2017-11-10
words: 8284
flesch: 28
summary: -IIA: results from the UDACS study Biallelic mutations in PLA2G5, encoding group V phospholipase A 2 , cause benign fleck retina recapitulate the mitochondriopathy of the homologous null mouse Loss-offunction mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness Impairment of PARK14-dependent Ca 2D signalling is a novel determinant of Parkinson's disease Male mice that do not express group VIA phospholipase A 2 produce spermatozoa with impaired motility and have greatly reduced fertility Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase Adipose triglyceride lipase contributes to cancer-associated cachexia The G 0
keywords: -iia; acid; activity; cpla; enzymes; family; gene; group; human; ipla; lipoquality; mice; phospholipase; phospholipids; role; secretory; spla; type
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item: #88 of 104
id: cord-324617-yok7mh70
author: Andreata-Santos, Robert
title: Transcutaneous Administration of Dengue Vaccines
date: 2020-05-06
words: 6349
flesch: 38
summary: Similar serum antibody responses were also measured in mice immunized virus particles purified from cell culture supernatants by anionic chromatography ( Figure S2 ). Similar serum antibody responses were also measured in mice immunized virus particles purified from cell culture supernatants by anionic chromatography ( Figure S2 ).
keywords: antigen; cells; d route; denv2; figure; mice; responses; route; tc route; vaccine; virus
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item: #89 of 104
id: cord-326223-q6e60nf8
author: Gembardt, Florian
title: Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents
date: 2005-02-16
words: 3961
flesch: 49
summary: It was also shown that ACE2 expression can be upregulated by blockade of AT 1 -receptors [27] . The expression in mouse was most pronounced higher than in rat in kidney (∼31.9-fold), colon (∼18.6-fold), and ileum (∼12.0-fold) (Fig. 3) , whereas in bladder (∼2.5-fold) and ventricle (∼2.1-fold) ACE2 expression in rat exceeded the mouse.
keywords: ace2; activity; ang-(1; angiotensin; expression; germany; gmbh; mouse; mrna; protein; rat; species
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item: #90 of 104
id: cord-327568-5vo4nmei
author: Tosini, Fabio
title: Delivery of SA35 and SA40 peptides in mice enhances humoral and cellular immune responses and confers protection against Cryptosporidium parvum infection
date: 2019-05-15
words: 7412
flesch: 46
summary: Values from control mice are between 33 and 29 cycles, equivalent to DNA amounts from 6 to 100 oocysts, whereas values from immunised mice are between 39 to 35 cycles, equivalent to DNA amounts from 0.1 to 5 oocysts been the first example of effective prevention for neonates [48] and it has been extensively applied as part of the WHO Maternal and Neonatal Tetanus Elimination (MNTE) program. Neonates born from immunised mice and infected with 1 × 10(5) oocysts showed a significant reduction of oocysts and intestinal forms (23 and 42%, respectively).
keywords: cells; control; cryptosporidium; immunisation; mice; mix; oocysts; parvum; pbs; sa35; sa35/40; sa40
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item: #91 of 104
id: cord-329061-1xut73dq
author: Bhatt, Pravin N.
title: Characterization of the Virus of Sialodacryoadenitis of Rats: A Member of the Coronavirus Group
date: 1972-08-17
words: 4297
flesch: 56
summary: (2) A comparative titration was done in mice two days old, 13 days old, and 22 days old that were inoculated ic with viral stock passaged 12 times in mouse brain. (4) The titer of virus between the fifth and 29th passage in mouse brain has remained relatively stable at 10 3 .
keywords: brain; cultures; days; inoculation; mice; mouse; rats; sda; virus
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item: #92 of 104
id: cord-332233-01rdlf8l
author: Tully, Thomas N.
title: CHAPTER 12 MICE AND RATS
date: 2009-12-31
words: 12450
flesch: 54
summary: Inducing and maintaining mouse patients under anesthesia can be very challenging. Therefore, inhalant anesthetic agents (e.g., isofl urane, sevofl urane) are recommended for anesthetizing mouse patients.
keywords: animals; blood; cage; disease; examination; hair; mice; mouse; parasites; patient; rats; rodents; skin; treatment; urine; virus; water
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item: #93 of 104
id: cord-333043-fe24ezt6
author: Traavik, T.
title: “Runde“ virus, a coronavirus-like agent associated with seabirds and ticks
date: 1977
words: 4196
flesch: 57
summary: This corona-like virus has been tentatively termed Runde virus. Circumstances of tickcollection strongly support that Runde virus is an arbovirus in the ecological sense, and not a mechanical pick-up : 1.
keywords: cell; cent; cultures; days; mice; mouse; runde; seabird; ticks; uriae; virus; viruses
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item: #94 of 104
id: cord-335424-h84jtx94
author: Kirkland, J. L.
title: Senolytic drugs: from discovery to translation
date: 2020-08-04
words: 9926
flesch: 34
summary: Senescent cells can develop peri-centromeric distended satellite DNA (senescence-associated distension of satellites [SADS]), which can be detected with antibodies to CENP-B, another marker for detecting senescent cells [56] . If an agent is truly senolytic, then: 1) Senescent cells should be present in association with the phenotype, 2) Individuals without senescent cells should not have the phenotype, 3) Inducing accumulation of senescent cells should cause the phenotype, 4) Clearing these induced senescent cells should alleviate the phenotype, 5)
keywords: adipose; age; aging; bone; cancer; cells; disease; drugs; dysfunction; factors; human; mice; sasp; senescent; senescent cells; senolytic; tissue; trials
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item: #95 of 104
id: cord-337464-otwps68u
author: Parray, Hilal Ahmed
title: Hybridoma technology a versatile method for isolation of monoclonal antibodies, its applicability across species, limitations, advancement and future perspectives
date: 2020-05-27
words: 12214
flesch: 34
summary: The rabbit IgGs are somewhat simpler than the mouse and human antibodies. Human hybridoma technology which allows the direct generation of human antibodies in a native form, is the most direct effective approach for the production of natural therapeutic and diagnostic antibodies with no additional modifications require [54] .
keywords: antibodies; antibody; antigen; applications; cells; chicken; development; fusion; generation; human; hybridoma; hybridoma technology; igg; immune; mabs; method; mice; monoclonal; mouse; myeloma; production; rabbit; technology; therapeutic; transgenic; virus
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item: #96 of 104
id: cord-345359-okmkgsbr
author: Ohno, Marumi
title: Influenza virus infection affects insulin signaling, fatty acid-metabolizing enzyme expressions, and the tricarboxylic acid cycle in mice
date: 2020-07-02
words: 6504
flesch: 40
summary: Samples collected at 6 dpi showed the greatest effect of PR8 virus infection on serum metabolomes, as indicated by principle component analyses with high contribution rates of principle component 1 (PC1; 51.4%; Supplemental Fig. Moreover, PC1 scores for the control and PR8 virus-infected mice were negative and positive, respectively, suggesting that the PC1 score was positively related to the effects of PR8 virus infection.
keywords: acid; cycle; dpi; fatty; glucose; infection; influenza; insulin; levels; mice; pr8; pr8 virus; tca; virus
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item: #97 of 104
id: cord-347039-eap592i7
author: Lee, Seung-Hwan
title: Maneuvering for advantage: the genetics of mouse susceptibility to virus infection
date: 2003-08-31
words: 6191
flesch: 32
summary: To date more than 30 mouse loci (Table 1 ) and many fewer human genes ( Table 2 ) have been associated with the outcome of virus infection [1, 2] . In this review we illustrate the contribution of mouse genetics to our understanding of mechanisms of host resistance to virus infection.
keywords: cells; class; gene; host; human; infection; mhc; mice; mouse; receptor; resistance; strains; susceptibility; virus
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item: #98 of 104
id: cord-348091-pnvn0x4q
author: Nolte, Thomas
title: Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse
date: 2016-02-13
words: 47214
flesch: 36
summary: Metaplasia,hepatocytic at the interface between endocrine and exocrine tissue Apoptosis of mouse pancreatic acinar cells after duct ligation Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma Intermittent oral coadministration of a gamma secretase inhibitor with dexamethasone mitigates intestinal goblet cell hyperplasia in rats Salivary gland structure and function in experimental diabetes mellitus Gastric hamartomatous tumours in a transgenic mouse model expressing an activated dioxin/Ah receptor Age changes in the salivary glands of Wistar Institute rats with particular reference to the submandibular glands Druginduced acute pancreatitis: an evidence-based review In Flynn's Parasites of Laboratory Animals 2nd ed. • Hypertrophic cells with foamy cytoplasm characterized by clear vesicles with eosinophilic fine granules Differential diagnoses • Artifact: Medium-sized clear vesicles within the cytoplasm of acinar cells, especially at the periphery.
keywords: acinar cell; acini; apoptosis; atrophy; basal; cases; cell; cell death; cell hyperplasia; cell infiltrate; cell necrosis; chronic; comment; cytoplasm; diffuse; ducts; edema; eosinophilic; epithelium; erosion; et al; exocrine; features; figure; glands; glandular; growth; hyperplasia; infiltration; inflammation; layers; lesions; loss; membrane; mice; mouse; mucosa; muscularis; necrosis; pancreas; pancreatic; pathogenesis; present; rats; salivary; stomach; submandibular; term; tissue; tumor; type; ulcer
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item: #99 of 104
id: cord-350593-bvmg7f15
author: McDonald, R.S.
title: Proportional mouse model for aerosol infection by influenza
date: 2012-08-21
words: 6567
flesch: 41
summary: A two-year study of contagion in a tuberculosis ward Possible increased pathogenicity of pandemic (H1N1) 2009 influenza virus upon reassortment The use of an animal model to study transmission of influenza virus infection Experimental transmission of influenza virus infection in mice. Their low cost, small size, relative susceptibility to the virus and ease of handling make mice a favourable platform for studying influenza virus infections.
keywords: aerosol; dose; exposure; infection; influenza; mice; min; mouse; pcr; study; tcid; time; virus
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item: #100 of 104
id: cord-351011-v4zmksio
author: Golden, Joseph W.
title: Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease
date: 2020-07-09
words: 4705
flesch: 45
summary: Transcriptomic profiling in mouse lungs indicated that female mice that succumbed to disease had modestly lower levels of IL-6, CXCl-2 and IL-1RA 315 suggesting a less intense inflammatory response. Other recently reported SARS-CoV-2 murine models involved transduction of mouse lungs with 260 a replication-incompetent Adenovirus virus or an adeno associated virus (AAV) encoding the hACE2 gene (35, 36) .
keywords: cells; cov-2; disease; fig; hace2; infection; k18; lung; mice; sars
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item: #101 of 104
id: cord-352480-1ay8y7li
author: Wang, Ting
title: Vaccination with recombinant adenovirus expressing multi-stage antigens of Toxoplasma gondii by the mucosal route induces higher systemic cellular and local mucosal immune responses than with other vaccination routes
date: 2017-04-03
words: 4744
flesch: 38
summary: Current research on T. gondii vaccines only focuses on antigens expressed in the tachyzoite stage, which only induce partial protective immunity [20, 28, 38, 44] . Furthermore, the higher survival rate (50%) and lower cyst numbers observed in the intraoral and intranasal groups all indicate that Ad-UMAS is far more effective in protecting mice against T. gondii infection via the mucosal route.
keywords: gondii; immunization; infection; mice; mucosal; responses; umas; vaccination
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item: #102 of 104
id: cord-353190-7qcoxl81
author: Nicklas, Werner
title: Viral Infections of Laboratory Mice
date: 2012-05-17
words: 27792
flesch: 37
summary: The term murine hepatitis virus (MHV; commonly referred to as 'mouse hepatitis virus') A model for the study of viral infection, pathogenesis, and clearance Histopathological characterization of the naturally occurring hepatotropic virus infections of nude mice Detection methods for the identification of rodent viral and mycoplasmal infections Reverse transcriptionpolymerase chain reaction detection and nucleic acid sequence confirmation of reovirus infection in laboratory mice with discordant serologic indirect immunofluorescence assay and enzyme-linked immunosorbent assay results Diagnosis of murine infections in relation to test methods employed Reovirus 3 not detected by reverse transcriptase-mediated polymerase chain reaction analysis of preserved tissue from infants with cholestatic liver disease Detection of reovirus type 3 by use of fluorogenic nuclease reverse transcriptase polymerase chain reaction Detection of reovirus by reverse transcription-polymerase chain reaction using primers corresponding to conserved regions of the viral L1 genome segment Isolation of a non-pathogenic tumour-destroying virus from mouse ascites An oncolytic virus recovered from Swiss mice during passage of an ascites tumour Mouse hepatitis virus Enterotropic mouse hepatitis virus Effects of air temperature and relative humidity on coronavirus survival on surfaces Asymptomatic infection of mouse hepatitis virus in the rat Effects of experimental infection of the deer mouse (Peromyscus maniculatus) with mouse hepatitis virus Isolation of a latent murine hepatitis virus from cultured mouse liver cells Induction of lytic plaques by murine leukemia virus in murine sarcoma virus-transformed nonproducer mouse cells persistently infected with mouse hepatitis virus MHV-S Mouse hepatitis virus biology and epizootiology The cellular and molecular pathogenesis of coronaviruses Enterotropic coronavirus (mouse hepatitis virus) in mice: influence of host age and strain on infection and disease Response of genetically susceptible and resistant mice to intranasal inoculation with mouse hepatitis virus JHM Duration of mouse hepatitis virus infection: studies in immunocompetent and chemically immunosuppressed mice Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4þ and CD8þ T cells Role of CD4þ and CD8þ T cells in mouse hepatitis virus infection in mice Antibody prevents virus reactivation within the central nervous system Mouse hepatitis virus Enterotropic mouse hepatitis virus infection in nude mice Persistent transmission of mouse hepatitis virus by transgenic mice Duration of challenge immunity to coronavirus JHM in mice Virus strain specificity of challenge immunity to coronavirus Duration and strain-specificity of immunity to enterotropic mouse hepatitis virus Passively acquired challenge immunity to enterotropic coronavirus in mice Epizootic coronaviral typhlocolitis in suckling mice Isolation of mouse hepatitis virus from infant mice with fatal diarrhea Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice Adverse effects of mouse hepatitis virus on ascites myeloma passage in the BALB/eJ mouse Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice Tolllike receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice Granulomatous peritonitis and pleuritis in interferon-gamma gene knockout mice naturally infected with mouse hepatitis virus Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice Vertical transmission of mouse hepatitis virus infection in mice Tissue distribution and duration of mouse hepatitis virus in naturally infected immunocompetent ICR (CD-1) and immunodeficient athymic nudenu mouse strains used for ovarian transplantation and in vitro fertilization Rederivation of inbred strains of mice by means of embryo transfer Risk assessment of mouse hepatitis virus infection via in vitro fertilization and embryo transfer by the use of zona-intact and laser-microdissected oocytes Mouse hepatitis virus immunofluorescence in formalin-or Bouin's-fixed tissues using trypsin digestion Comparison of isolation in cell culture with conventional and modified mouse antibody production tests for detection of murine viruses Monoclonal antibody solution hybridization assay for detection of mouse hepatitis virus infection Detection of rodent coronaviruses in tissues and cell cultures by using polymerase chain reaction Sequence analysis and molecular detection of mouse hepatitis virus using the polymerase chain reaction Detection of mouse hepatitis virus by the polymerase chain reaction and its application to the rapid diagnosis of infection Detection of rodent coronaviruses by use of fluorogenic reverse transcriptase-polymerase chain reaction analysis An immunofluorescence test for detection of serum antibody to rodent coronaviruses Simultaneous detection of antibodies to mouse hepatitis virus recombinant structural proteins by a microsphere-based multiplex fluorescence immunoassay Differences in antibody production against mouse hepatitis virus (MHV) among mouse strains Maternally-derived passive immunity to enterotropic mouse hepatitis virus Mouse hepatitis virus: molecular biology and implications for pathogenesis Maintenance of pluripotency in mouse embryonic stem cells persistently infected with murine coronavirus Replication of murine coronaviruses in mouse embryonic stem cell lines.
keywords: age; animals; antibodies; antibody; cells; choriomeningitis; clinical; colonies; days; detection; disease; experimental; hepatitis; hepatitis virus; host; immune; infection; inoculation; laboratory; laboratory mice; lesions; mhv; mice; mouse; mousepox; murine; parvovirus; pcr; research; results; strains; testing; transmission; virus; virus infection; viruses; weeks
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item: #103 of 104
id: cord-353600-5wo74ms4
author: Tyrrell, Daniel J.
title: Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
date: 2020-09-11
words: 8249
flesch: 22
summary: Vascular cells such as vascular smooth muscle cells (VSMCs) have been shown in animal models to have an elevated IL6 production with ageing before any signs of atherosclerosis development 86, 87 . Finally, we propose that future experimental and clinical investigation will be required to determine the contribution of this inflamma tory pathway in age related atherosclerosis.
keywords: aged; ageing; atherosclerosis; bone; cells; chip; clonal; disease; function; il-6; il6; levels; marrow; mice; myeloid; risk; signalling; vascular
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item: #104 of 104
id: cord-354325-r73datur
author: Berger, Mitchell
title: Therapeutic Applications of Monoclonal Antibodies
date: 2002-07-31
words: 12352
flesch: 35
summary: Prevention of respiratory syncytial virus infections: indications for the use of palivizumab and update on the use of RSV-IGIV Respiratory syncytial virus (RSV) immune globulin and palivizumab for prevention of RSV infection Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display libraries Effective antibody therapy in herpes simplex virus ocular infection: characterization of recipient immune response Use of monoclonal antibody directed against herpes simplex virus glycoproteins to protect mice against acute virus-induced neurological disease Ability of monoclonal antibody to herpes simplex virus glycoprotein gB to promote healing of herpetic skin lesions in nude mice Protection against herpetic ocular disease by immunotherapy with monoclonal antibodies to herpes simplex virus glycoprotein Passive immunization with monoclonal antibodies against herpes simplex virus glycoproteins protects mice against herpetic ocular disease Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential Topically applied human recombinant monoclonal IgG 1 antibody and its Fab and F(ab')2 fragments protect mice from vaginal transmission of HSV-2 Epitopes involved in antibody-mediated protection from Ebola virus Isolation and characterization of human monoclonal antibodies to digoxin Drug-specific antibodies as antidotes for tricyclic antidepressant overdose Automated Immunosensing system for 3,5,6-trichloro-2-pyridinol application to surface water samples Exploiting antibody-based technologies to manage environmental pollution Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat Prevention of paraquat toxicity in suspensions of alveolar type II cells by paraquatspecific antibodies Production and characterization of a monoclonal antibody against domoic acid and its application to enzyme immunoassay Antiphencyclidine monoclonal antibody therapy significantly changes phencyclidine concentrations in brain and other tissues in rats Pharmacodynamics of a monoclonal antiphencyclidine Fab with broad selectivity for phencyclidine-like drugs Antibodies as pharmacokinetic and metabolic modifiers of neurotoxicity Antibodies may treat overdoses, addiction Phencyclidine-specific Fab fragments alter phencyclidine disposition in dogs Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats Drug-fighting drugs Reactive immunization A catalytic antibody against cocaine attenuates cocaine's cardiovascular effects in mice: a dose and time course analysis Natural and artificial enzymes against cocaine. The vectors will replicate in the COS cells and transiently express and secrete reshaped human antibodies.
keywords: antibodies; antibody; antigen; binding; cancer; cells; cmv; fragments; human; immune; mabs; mice; monoclonal; monoclonal antibodies; mouse; murine; patients; regions; specific; therapy; treatment; tumor; use; variable; virus
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