item: #1 of 29
id: cord-011333-yyhwtnza
author: Faienza, Maria Felicia
title: Childhood obesity, cardiovascular and liver health: a growing epidemic with age
date: 2020-02-04
words: 4298
flesch: 39
summary: Interplay and common pathways from a toxic and obesogenic environment Diet and contaminants: driving the rise to obesity epidemics Chinese famine exposure in infancy and metabolic syndrome in adulthood: results from the China health and retirement longitudinal study Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age IGF2 gene variants and risk of hypertension in obese children and adolescents Risk factors for subclinical atherosclerosis in diabetic and obese children Elevated endothelin-1 (ET-1) levels may contribute to hypoadiponectinemia in childhood obesity Endothelial and metabolic function interactions in overweight/obese children Metabolic, inflammatory, endothelial and haemostatic markers in a group of Italian obese children and adolescents Oxidative stress in obesity and metabolic syndrome in children and adolescents Overweight in children and adolescents: Appropriate metabolic screenings and associated comorbidities should start as early as possible in obese children and adolescents.
keywords: adolescents; bmi; childhood; children; disease; fatty; liver; metabolic; obesity; risk
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item: #2 of 29
id: cord-012493-pwbzffo9
author: Alligier, Maud
title: OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions
date: 2020-01-16
words: 11981
flesch: 36
summary: A critical part of addressing this global epidemic is to improve the evidence base for more effective treatments for obesity; however, a challenge revealed in the randomized, controlled trials (RCTs) of obesity interventions is the remarkable heterogeneity of interindividual and intraindividual responses among adult patients -whether the intervention pertains to lifestyle (dietary, physical activity [PA]), or is a pharmacological or surgical intervention aiming at weight loss. Funded by a European grant, a group of European obesity researchers convened in 2018 to create a plan for helping shape future RCTs in the field of obesity by identifying the minimal set of variables that should be included in trials of different kinds of obesity interventions, whatever the type and the endpoints of the intervention.
keywords: assessment; body; clinical; core; core set; data; disease; fat; group; health; interventions; loss; mass; measures; obedis; obesity; risk; set; sleep; studies; trials; variables; weight
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item: #3 of 29
id: cord-034066-fsp7e5x5
author: Di Figlia-Peck, Stephanie
title: Treatment of children and adolescents who are overweight or obese
date: 2020-10-21
words: 10692
flesch: 39
summary: The researchers concluded that CAAT holds promise as a treatment modality since overweight and obese children are often less effective in regulating food intake compared to normal weight children. Several studies of weight management interventions have shown that children can successfully increase their step count from baseline as part of an intervention.
keywords: activity; adolescents; bmi; change; children; eating; food; group; health; interventions; loss; management; obesity; overweight; program; school; surgery; time; treatment; weight
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item: #4 of 29
id: cord-261891-yiiz9s53
author: Czernichow, Sébastien
title: Obesity doubles mortality in patients hospitalized for SARS‐CoV‐2 in Paris hospitals, France: a cohort study on 5795 patients
date: 2020-08-20
words: 2717
flesch: 49
summary: 5 About ten years ago, against the backdrop of the H1N1 influenza epidemic, it was clearly pointed out in a meta-analysis on more than 3000 individuals, that people with severe obesity had a two-fold increased risk for intensive care unit (ICU) admission and mortality, compared to counterparts without obesity. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Joint international consensus statement for ending stigma of obesity Obesity and emergency care in the French CONSTANCES cohort Body-mass index and mortality among adults with incident type 2 diabetes Obesity and site-specific nosocomial infection risk in the intensive care unit Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: a systematic review and metaanalysis Obesity is associated with severe forms of COVID-19 High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation Covid-19 in Critically Ill Patients in the Seattle Region -Case Series Initializing a hospital-wide data quality program.
keywords: bmi; copyright; covid-19; data; mortality; obesity; patients; people
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item: #5 of 29
id: cord-265139-x7g3jcjm
author: Zaiou, Mohamed
title: The Emerging Role and Promise of Circular RNAs in Obesity and Related Metabolic Disorders
date: 2020-06-16
words: 8185
flesch: 34
summary: This assumption was based on the observation that treatment of differentiated primary mouse subcutaneous adipocytes with soluble tumor necrosis factor (TNF)-α led to significant reduction in circRNAs expression [80] . In this study, thousands of adipose circRNAs were identified to be regulated during adipogenesis.
keywords: adipogenesis; adipose; circrnas; diseases; expression; function; human; inflammation; insulin; metabolic; obesity; potential; protein; role; studies; tissue
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item: #6 of 29
id: cord-266380-lu6hj3a2
author: Alfaris, Nasreen
title: Management of obesity in Saudi Arabia during the era of COVID‐19: A clash of two pandemics
date: 2020-10-01
words: 631
flesch: 52
summary: key: cord-266380-lu6hj3a2 authors: Alfaris, Nasreen title: Management of obesity in Saudi Arabia during the era of COVID‐19: A clash of two pandemics date: 2020-10-01 journal: Obesity (Silver Spring) DOI: 10.1002/oby.23055 sha: doc_id: 266380 cord_uid: Despite these measures, the pandemic resulted in the magnification of obesity stigma.
keywords: obesity; saudi
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item: #7 of 29
id: cord-267505-4tw7kfek
author: Frühbeck, Gema
title: European Association for the Study of Obesity Position Statement on the Global COVID-19 Pandemic
date: 2020-04-27
words: 1956
flesch: 33
summary: In the absence of physical consultations with healthcare professionals, obesity care may be delivered using telemedicine. A retrospective cohort study conducted in France found that patients with severe obesity (body mass index [BMI] > 40 kg/m 2 ) who contracted COVID-19 were more likely to need invasive mechanical ventilation, independent of age, hypertension, and diabetes [11] .
keywords: covid-19; easo; health; obesity; pandemic; people
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item: #8 of 29
id: cord-277074-1emlkii0
author: Ekiz, Timur
title: Relationship between COVID-19 and obesity
date: 2020-06-02
words: 771
flesch: 47
summary: On the other hand, sarcopenia, the age-related loss of muscle mass and function, with obesity (sarcopenic obesity) is seen in approximately one-fifth of older populations. Interestingly, The United States of America ranked first in terms of obesity prevalence (36.2%), overweight prevalence (31.7%), and also the number of total deaths.
keywords: covid-19; obesity; prevalence
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item: #9 of 29
id: cord-277803-7p1qu2rf
author: Rubino, Francesco
title: Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery
date: 2020-05-07
words: 6092
flesch: 25
summary: National diabetes statistics report 2020: estimates of diabetes and its burden in the United States Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study Predictors of mortality over 8 years in type 2 diabetic patients: Translating Research Into Action for Diabetes (TRIAD) Risk factors for mortality among patients with diabetes: the Translating Research Into Action for Diabetes (TRIAD) Study Years of life lost due to obesity Morbidity and mortality associated with obesity Prevalence and ethnicity of sleep-disordered breathing and obesity in children Adiposity in relation to age as predictor of severity of sleep apnea in children with snoring Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome Combining risk estimates from observational studies with different exposure cutpoints: a meta-analysis on body mass index and diabetes type 2 Body mass index, abdominal fatness, and heart failure incidence and mortality: a systematic review and dose-response meta-analysos of prospective studies Emerging concepts in the medical and surgical treatment of obesity Using the Edmonton Obesity Staging System to predict mortality in a population-representative cohort of people with overweight and obesity Edmonton Obesity Staging System: association with weight history and mortality risk Non-alcoholic fatty liver disease Practical approach to non-alcoholic fatty liver disease in patients with diabetes Nonalcoholic fatty liver disease and risk of incident type 2 diabetes: a meta-analysis Nonalcoholic fatty liver disease increases risk of incident chronic kidney disease: a systematic review and meta-analysis NAFLD and diabetes mellitus Nonalcoholic fatty liver disease: a systematic review The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe Bariatric surgery versus intensive medical therapy for diabetes-5-year outcomes Microvascular outcomes in patients with diabetes after bariatric surgery versus usual care: a matched cohort study Bariatric surgery for non-alcoholic steatohepatitis in obese patients Bariatric surgery reduces features of nonalcoholic steatohepatitis in morbidly obese patients Lifestyle intervention and medical management with vs without Roux-en-Y gastric bypass and control of hemoglobin A1c, LDL cholesterol, and systolic blood pressure at 5 years in the Diabetes Surgery Study Bariatric-metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial Clinical and patient-centered outcomes in obese patients with type 2 diabetes 3 years after randomization to Rouxen-Y gastric bypass surgery versus intensive lifestyle management: the SLIMM-T2D study Survival among high-risk patients after bariatric surgery A simple prediction rule for all-cause mortality in a cohort eligible for bariatric surgery Long-term mortality after gastric bypass surgery Long-term mortality rates (>8-year) improve as compared to the general and obese population following bariatric surgery Survival and changes in comorbidities after bariatric surgery Predictors of long-term mortality after bariatric surgery performed in Veterans Affairs medical centers Cancer risk following bariatric surgery-systematic review and meta-analysis of national population-based cohort studies Bariatric surgery and the risk of cancer in a large multisite cohort Bariatric surgery is associated with reduced risk of breast cancer in both premenopausal and postmenopausal women Bariatric surgery is associated with a lower rate of death after myocardial infarction and stroke: a nationwide study Success (but unfinished) story of metabolic surgery Metabolic surgery for the treatment of type 2 diabetes in obese individuals Clinical outcomes of metabolic surgery: efficacy of glycemic control, weight loss, and remission of diabetes Cost-effectiveness of bariatric surgery for severely obese adults with diabetes Preoperative Prediction of type 2 diabetes remission after gastric bypass surgery: a comparison of DiaRem scores and ABCD scores Type 2 diabetes remission 2 years post Roux-en-Y gastric bypass and sleeve gastrectomy: the role of the weight loss and comparison of DiaRem and DiaBetter scores The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass Preoperative prediction of type 2 diabetes remission after Roux-en-Y gastric bypass surgery: a retrospective cohort study Validating risk prediction models of diabetes remission after sleeve gastrectomy Incidence and remission of type 2 diabetes in relation to degree of obesity at baseline and 2 year weight change: the Swedish Obese Subjects (SOS) study Health care use during 20 years following bariatric surgery Impact of bariatric surgery on health care costs of obese persons: a 6-year follow-up of surgical and comparison cohorts using health plan data The business case for bariatric surgery revisited: a non-randomized case-control study Long-term expenditures associated with bariatric surgery in VA Association between bariatric surgery and long-term health care expenditures among veterans with severe obesity Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2020 Efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes: a systematic review and network meta-analysis study protocol Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials Consensus recommendations for the management of diabetes in patients with COVID-19 Diets with high or low protein content and glycemic index for weight-loss maintenance Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/ topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial Joint international consensus statement for ending stigma of obesity Bariatric, metabolic, and diabetes surgery: what's in a name? Related factors of quality of life of type 2 diabetes patients: a systematic review and meta-analysis Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus Bariatric surgery has been used for decades to treat patients with severe obesity.
keywords: candidates; complications; covid-19; diabetes; disease; metabolic; mortality; obesity; patients; risk; surgery; type; weight
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item: #10 of 29
id: cord-288255-p8uzrsbd
author: Goossens, Gijs H.
title: Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity
date: 2020-08-13
words: 7056
flesch: 32
summary: COVID-19: consider cytokine storm syndromes and immunosuppression Validation of predictors of disease severity and outcomes in COVID-19 patients: a descriptive and retrospective study APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort Apolipoprotein E -a multifunctional protein with implications in various pathologies as a result of its structural features Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders Angiotensin II receptors and angiotensin II receptor antagonists Physiology and pathophysiology of the adipose tissue renin-angiotensin system The renin-angiotensin system in the pathophysiology of type 2 diabetes Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2 Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor A pneumonia outbreak associated with a new coronavirus of probable bat origin Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. In COVID-19 patients, elevated plasma concentrations of both proinflammatory Th1 and anti-inflammatory Th2 cytokines were found [3] .
keywords: adipose; angiotensin; coronavirus; cov-2; covid-19; disease; immune; infection; obesity; patients; people; risk; sars; tissue; treatment
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item: #11 of 29
id: cord-290551-a02tueuu
author: Singh, Shailendra
title: Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study.
date: 2020-08-21
words: 2720
flesch: 49
summary: Our study using a large nationally representative database showed that COVID-19 patients with any degree of obesity had a significantly higher risk of hospitalization and intubation or death compared to patients without obesity. Advanced age and male gender are major risk factors for worse prognosis and higher mortality in COVID-19 patients 6 .
keywords: covid-19; data; diagnosis; group; obesity; patients; risk
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item: #12 of 29
id: cord-291627-5dqwyd9r
author: Yadav, Rakhee
title: SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity
date: 2020-07-21
words: 4367
flesch: 40
summary: However, whether obesity, over and above its cardio-metabolic co-morbidities might independently contribute to COVID-19 risk; needs more robust and detailed prospective survey. 25 Several reports from around the world identified obesity and severe obesity as risk factors for hospitalization and mechanical ventilation.
keywords: adipose; coronavirus; covid-19; disease; infection; influenza; obesity; patients; risk; sars; tissue
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item: #13 of 29
id: cord-300991-ipy24zxp
author: Khan, Amira Sayed
title: Obesity and COVID-19: Oro-Naso-Sensory Perception
date: 2020-07-08
words: 5986
flesch: 41
summary: There is no direct report available on the loss of these chemical senses in obese COVID-19 patients. Epidemiological data confirm that there is an increased rate of pneumonia and RTI in COVID-19 obese patients [12] .
keywords: cells; cov-2; covid-19; infection; inflammation; loss; obese; obesity; olfactory; patients; sars; taste; tnf
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item: #14 of 29
id: cord-301423-stod75j2
author: Parekh, Niyati
title: Health behaviours during the coronavirus disease 2019 pandemic: implications for obesity
date: 2020-08-04
words: 2766
flesch: 34
summary: Television watching is an environmental stimulus that increases food intakes, independent of hunger-satiety signals or food palatability; therefore, consumption of meals and energy-dense snack foods in front of the television may result in excess energy, fat and sugar intakes (11) . Modern society has resulted in an increased prevalence of deficient sleep health, which encompasses inadequate sleep duration, poor sleep quality and sleep disorders.
keywords: activity; behaviours; covid-19; foods; health; individuals; obesity; pandemic; sleep
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item: #15 of 29
id: cord-301833-q8jiep32
author: Peres, Karina Colombera
title: Body Mass Index and Prognosis of COVID-19 Infection. A Systematic Review
date: 2020-08-14
words: 3697
flesch: 41
summary: (23) described that the distribution of BMI categories in COVID-19 patients admitted to ICU care in France differed from the control patients with non-SARS-Cov-2 respiratory disease. medRxiv Targeting the adipose tissue in COVID-19 Is adipose tissue a reservoir for viral spread, immune activation, and cytokine amplification in coronavirus disease Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-Covid-net, 14 states Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality Complex immune dysregulation in COVID-19 patients with severe respiratory failure Role of innate and adaptive immunity in obesity-associated metabolic disease Obesity cardiomyopathy: pathogenesis and pathophysiology Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid? Mechanisms of thrombosis in obesity
keywords: bmi; covid-19; disease; obesity; patients; review; risk; studies
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item: #16 of 29
id: cord-311535-ppkwd1kp
author: Korakas, Emmanouil
title: Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes
date: 2020-07-01
words: 2781
flesch: 18
summary: Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome Cellular mechanisms underlying obesityinduced arterial stiffness Oxidative stress and vascular disease in diabetes: is the dichotomization of insulin signaling still valid? Prolonged treatment with angiotensin 1-7 improves endothelial function in diet-induced obesity Mechanisms of thrombosis in obesity Takotsubo Cardiomyopathy Triggered by Influenza A Virus Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome Obesity and type 2 diabetes mellitus drive immune dysfunction, infection development, and sepsis mortality Complex immune dysregulation in COVID-19 patients with severe respiratory failure Critical role for the NLRP3 inflammasome during acute lung injury Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes Clinical features of patients infected with 2019 novel coronavirus in Wuhan Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function Complement receptor C5aR1 inhibition reduces pyroptosis in hDPP4-transgenic mice Infected with MERS-CoV Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission Obesity induces a phenotypic switch in adipose tissue macrophage polarization Adipocytes properties and crosstalk with immune system in obesity-related inflammation Role of innate and adaptive immunity in obesity-associated metabolic disease HLH Across Speciality Collaboration, UK. key: cord-311535-ppkwd1kp authors: Korakas, Emmanouil; Ikonomidis, Ignatios; Kousathana, Foteini; Balampanis, Konstantinos; Kountouri, Aikaterini; Raptis, Athanasios; Palaiodimou, Lina; Kokkinos, Alexander; Lambadiari, Vaia title: Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes date: 2020-07-01 journal: Am J Physiol Endocrinol Metab DOI: 10.1152/ajpendo.00198.2020 sha: doc_id: 311535 cord_uid: ppkwd1kp Recent reports have shown a strong association between obesity and the severity of COVID-19 infection, even in the absence of other comorbidities.
keywords: activation; acute; cells; covid-19; infection; obesity; patients; risk
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item: #17 of 29
id: cord-316260-1t3ifsfi
author: Nogueira-de-Almeida, Carlos Alberto
title: COVID-19 and obesity in childhood and adolescence: A clinical review()()
date: 2020-08-04
words: 7977
flesch: 33
summary: key: cord-316260-1t3ifsfi authors: Nogueira-de-Almeida, Carlos Alberto; Ciampo, Luiz A. Del; Ferraz, Ivan S.; Ciampo, Ieda R.L. Del; Contini, Andrea A.; Ued, Fábio da V. title: COVID-19 and obesity in childhood and adolescence: A clinical review()() date: 2020-08-04 journal: J Pediatr (Rio J) DOI: 10.1016/j.jped.2020.07.001 sha: doc_id: 316260 cord_uid: 1t3ifsfi OBJECTIVE: To identify factors that contribute to the increased susceptibility and severity of COVID-19 in obese children and adolescents, and its health consequences. Facing children with suspected or confirmed COVID-19, health professionals should 1) diagnose excess weight; 2) advise on health care in times of isolation; 3) screen for comorbidities, ensuring that treatment is not interrupted; 4) measure levels of immunonutrients; 5) guide the family in understanding the specifics of the situation; and 6) refer to units qualified to care for obese children and adolescents when necessary.
keywords: adolescents; age; care; cells; childhood; children; coronavirus; cov-2; covid-19; disease; infection; inflammatory; obese; obesity; patients; response; review; risk; sars
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item: #18 of 29
id: cord-318391-2s0rjfn8
author: Akirov, Amit
title: Tackling Obesity During the COVID‐19 Pandemic
date: 2020-08-14
words: 2531
flesch: 44
summary: Their study demonstrated a shift in the age threshold of developing severe COVID-19 disease in obese patients, such that severe obesity places young patients in their 30s at a similar risk category as elderly normal weight patients [18] . Obesity has been observed to be associated with severe COVID-19 disease, independent of diabetes, hypertension and cardiovascular disease -concomitant disorders also known to contribute to severe disease [18] .Several potential underlying mechanisms have been proposed.
keywords: covid-19; diabetes; obese; obesity; patients; risk
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item: #19 of 29
id: cord-319580-awtp0mpg
author: McCartney, Stephen A.
title: Obesity as a contributor to immunopathology in pregnant and non‐pregnant adults with COVID‐19
date: 2020-08-11
words: 3710
flesch: 36
summary: Annals of internal medicine The role of adipose tissue immune cells in obesity and low-grade inflammation Adipocytes properties and crosstalk with immune system in obesity-related inflammation Inflamed fat: what starts the fire? medRxiv Facing the noncommunicable disease (NCD) global epidemic--the battle of prevention starts in utero--the FIGO challenge Prevalence of Obesity and Severe Obesity Among Adults: United States Obesity is associated with worse outcomes in COVID-19: Analysis of Early Data From Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality Obesity and COVID-19: an Italian snapshot Cytokine release syndrome in severe COVID-19 Clinical characteristics of 113 deceased patients with coronavirus disease 2019:
keywords: cells; covid-19; disease; immune; obesity; patients; response; tissue; women
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item: #20 of 29
id: cord-321997-3dkl6iha
author: Hussain, Abdulzahra
title: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease
date: 2020-04-29
words: 403
flesch: 31
summary: In addition to the known defective immune system in the obesity, the virulence of Covid-19 and the differences in the incidence of obesity across the world, it is not clear what is the magnitude /severity of liver disease could add to production of critical illness like severe pneumonia. Several other studies have reported obesity as a significant factor for mortality in Covid-19 patients [8-10].This subject is more important in the current Covid-19 crisis knowing the pandemic of obesity.
keywords: covid-19; obesity
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item: #21 of 29
id: cord-325055-todb1d4x
author: Rychter, Anna Maria
title: Should patients with obesity be more afraid of COVID‐19?
date: 2020-06-24
words: 3273
flesch: 39
summary: Clin Obes Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice Risk of COVID-19 for patients with obesity COVID 19 and the patient with obesity-the editors speak out Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-COVID-NET, 14 States High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation ICNARC report on COVID-19 in critical care Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. The Lancet Body weight and mortality in COPD: focus on the obesity paradox Pathophysiology and management of acute respiratory distress syndrome in obese patients The effects of obesity on lung volumes and oxygenation The effects of body mass index on lung volumes Obesity and acute lung injury Effect of body mass index in acute respiratory distress syndrome High positive end-expiratory pressure is associated with improved survival in obese patients with acute respiratory distress syndrome Tracheal trauma after difficult airway management in morbidly obese patients with COVID-19 Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury Obesity and susceptibility to severe outcomes following respiratory viral infection Obesity and respiratory infections: does excess adiposity weigh down host defense? Association of body mass index with mortality in cardiovascular disease: new insights into the obesity paradox from multiple perspectives Obesity paradox in patients with hypertension and coronary artery disease Obesity phenotypes and their paradoxical association with cardiovascular diseases Are metabolically healthy obese patients also hemorheologically healthy? Metabolically healthy obesity and risk of allcause and cardiovascular disease mortality Does COVID-19 disprove the obesity paradox in ARDS?
keywords: cov-2; covid-19; disease; lung; obesity; patients; risk; sars; weight
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item: #22 of 29
id: cord-325138-riu4jdc2
author: Hassink, Sandra G.
title: Obesity and Hunger Threaten the Foundations of Child Health
date: 2020-08-13
words: 3254
flesch: 42
summary: 33 SNAP is even more crucial in the economic downturn because increased access to and participation in SNAP reduces the rise in food insecurity for children 34 and risk of obesity in children under 3. 35 Households that experience reduction of SNAP benefits have increased household food insecurity, child food insecurity, housing instability and energy insecurity. Childhood obesity and food insecurity can co-occur, and in some children food insecurity is associated with an increased risk of obesity.
keywords: children; food; health; insecurity; nutrition; obesity; program; snap
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item: #23 of 29
id: cord-329308-ipui7lo6
author: Lim, Soo
title: Proper Management of People with Obesity during the COVID-19 Pandemic
date: 2020-06-30
words: 4617
flesch: 32
summary: Obesity (Silver Spring) Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center study Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality Association of higher body mass index (BMI) with severe coronavirus disease 2019 (COVID-19) in younger patients Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV Covid-19 in critically ill patients in the Seattle region: case series Surgical tracheostomies in COVID-19 patients: a multidisciplinary approach and lessons learned Body mass index, weight discrimination, and psychological, behavioral, and interpersonal responses to the coronavirus pandemic MYC-induced reprogramming of glutamine catabolism supports optimal virus replication COVID-19: consider cytokine storm syndromes and immunosuppression Coagulopathy and antiphospholipid antibodies in patients with Covid-19 Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis Regular exercise enhances the immune response against microbial antigens through up-regulation of toll-like receptor signaling pathways Participation profile of adults with class III obesity Immunologic profile of excessive body weight Impact of obesity on influenza a virus pathogenesis, immune response, and evolution Obesity and COVID-19: A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction Korean Society for the Study of Obesity Guideline for the Management of Obesity in Korea Angiotensin-converting enzyme 2 is an essential regulator of heart function SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2 Renin-angiotensin-aldosterone system inhibitors and risk of Covid-19 Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2 Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension Clinical consequences of angiotensin-converting enzyme inhibitor withdrawal in chronic heart failure: a double-blind, placebo-controlled study of quinapril: the Quinapril Heart Failure Trial Investigators Indications for ACE inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials Renin-angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia Pleiotropic effects of statins on the cardiovascular system Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins Collateral damage of the COV-ID-19 pandemic on nutritional quality and physical activity: perspective from South Korea
keywords: ace2; angiotensin; coronavirus; cov-2; covid-19; disease; obesity; pandemic; patients; people; risk; sars; system
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item: #24 of 29
id: cord-333368-kjrk8nn9
author: Huizinga, Gabrielle P
title: The Collision of Meta-Inflammation and SARS-CoV-2 Pandemic Infection
date: 2020-09-03
words: 5494
flesch: 33
summary: Obesity has been shown to be a risk factor for human papilloma virus incident infection, however obesity was not associated with how long the infection persisted 79 . A meta-analysis The role of increased body mass index in outcomes of sepsis: a systematic review and meta-analysis Body Habitus and Risk of Mortality in Pediatric Sepsis and Septic Shock: A Retrospective Cohort Study Outcomes and Resource Use Among Overweight and Obese Children With Sepsis in the Pediatric Intensive Care Unit Influence of Obesity Diagnosis With Organ Dysfunction, Mortality, and Resource Use Among Children Hospitalized With Infection in the United States The Role of Obesity in Sepsis Outcome among Critically Ill Patients: A Retrospective Cohort Analysis Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses Increased risk of influenza among vaccinated adults who are obese Impact of obesity on sepsis mortality:
keywords: covid-19; disease; infection; inflammation; macrophages; obesity; patients; risk; sars
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item: #25 of 29
id: cord-338317-ro041w5l
author: Lockhart, Sam M.
title: When two pandemics meet: Why is obesity associated with increased COVID-19 mortality?
date: 2020-06-29
words: 4667
flesch: 35
summary: In a rodent model 214 of obesity pulmonary resistance vessels were resistant to agonist and hypoxia induced 215 vasoconstriction ex vivo compared to lean controls 50 . 109 The majority of COVID-19 patients die having required artificial ventilation for hypoxemic respiratory 110 failure due to COVID-19 pneumonia 59 .
keywords: adipose; covid-19; insulin; lung; obesity; patients; pulmonary; resistance; risk; tissue
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item: #26 of 29
id: cord-344614-5zcylf6k
author: Moriconi, Diego
title: Obesity prolongs the hospital stay in patients affected by COVID-19, and may impact on SARS-COV-2 shedding
date: 2020-06-04
words: 3227
flesch: 40
summary: In our cohort of patients, the prevalence of obesity (28%) in COVID-19 patients is higher compared to that (11%) reported by Italian Health Institute (Epicentro) [18] . Patients were grouped by BMI ( ≥30 kg/m^2 or < 30 Kg/m2) as patients with obesity (OB, 29) and patients without obesity (N-OB, 71).
keywords: admission; covid-19; disease; hospital; obesity; patients; risk
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item: #27 of 29
id: cord-351223-nnuoadh6
author: Pettit, Natasha N.
title: Obesity is Associated with Increased Risk for Mortality Among Hospitalized Patients with COVID‐19
date: 2020-06-26
words: 1892
flesch: 46
summary: As we did not evaluate cause of death, we were unable to assess whether there is a common pathway to mortality in COVID-19 patients with obesity. [6] [7] Early reports from Chinese series identified hypertension, diabetes, chronic pulmonary disease, and cardiovascular disease as the comorbidities most consistently associated with hospitalization, respiratory support, intensive care unit (ICU) admission, and death in COVID-19 patients.
keywords: admission; covid-19; mortality; obesity; patients
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item: #28 of 29
id: cord-354805-5wnp02wd
author: Concepción‐Zavaleta, Marcio José
title: COVID‐19 and obesity: The intersection between a pandemic and an epidemic in a developing country
date: 2020-09-21
words: 795
flesch: 35
summary: key: cord-354805-5wnp02wd authors: Concepción‐Zavaleta, Marcio José; Gutiérrez‐Ortiz, Claudia; Coronado‐Arroyo, Julia Cristina; Zavaleta‐Gutiérrez, Francisca Elena; Concepción‐Urteaga, Luis Alberto title: COVID‐19 and obesity: The intersection between a pandemic and an epidemic in a developing country date: 2020-09-21 journal: Obesity (Silver Spring) DOI: 10.1002/oby.23027 sha: doc_id: 354805 cord_uid: 5wnp02wd We have read with great interest the prospective cohort study published by Czernichow et al (1), wherein they found that obesity doubles mortality in patients hospitalized with coronavirus disease (COVID‐19), using as an indicator anthropometric, the body mass index (BMI). Obesity doubles mortality in patients hospitalized for SARS-CoV-2 in Paris hospitals, France: a cohort study on 5795 patients Association between anthropometric indicators of obesity and cardiovascular risk factors among adults in Prediabetes in Peru: Consensus of experts Prevalence of diabetes and impaired fasting glucose in Peru: report from PERUDIAB, a national urban population-based longitudinal study The impact of obesity on severe disease and mortality in people with SARS-CoV-2: A systematic review and meta-analysis Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide Overweight and Obesity in Peru: Urgent need to have a public health policy for their control This article is protected by copyright.
keywords: covid-19; mortality; obesity
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item: #29 of 29
id: cord-354928-brliql4d
author: Wang, Jian
title: Overweight and obesity are risks factors of severe illness in patients with COVID‐19
date: 2020-07-31
words: 2410
flesch: 50
summary: This study aimed to investigate the clinical features of COVID-19 patients with overweight and obesity in a multi-center cohort of COVID-19 in Jiangsu province, China. All rights reserved The associated factors of respiratory failure in COVID-19 patients were analyzed by cox regression analysis ( Overweight and obesity are serious global health problems (19, 20) .
keywords: article; covid-19; obesity; overweight; patients; risk
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