item: #1 of 2876 id: cord-000001-ug7v899j author: Madani, Tariq A title: Clinical features of culture-proven Mycoplasma pneumoniae infections at King Abdulaziz University Hospital, Jeddah, Saudi Arabia date: 2001-07-04 words: 2459 flesch: 35 summary: It is hoped this information will assist clinicians in their approach and management of respiratory tract infections. A review of 101 hospitalized adult patients Respiration Atypical bacteria are a common cause of community-acquired pneumonia in hospitalized adults S Mycoplasma pneumoniae pneumonia requiring hospitalization, with emphasis on infection in the elderly Arch Intern Med Foy HM: Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients Role of Mycoplasma pneumoniae in acute respiratory-tract infections in Saudi paediatric patients The spectrum of pneumonia in 1983 at the Riyadh Armed Forces Community acquired acute bacterial and atypical pneumonia in Saudi Arabia Thorax Long-term epidemiology of infections with Mycoplasma pneumoniae Mycoplasma pneumoniae and adenovirus respiratory illness in military and university personnel Pneumonia caused by Mycoplasma pneumoniae infection The clinical spectrum and diagnosis of Mycoplasma pneumoniae infection Anemia and Mucocutaneous lesions due to Mycoplasma pneumoniae infections Clin Infect Dis Pericarditis and perimyocarditis associated with active Mycoplasma pneumoniae infection Mycoplasma pericarditis: evidence of invasive disease Clin Infect Dis CNS manifestations associated with Mycoplasma pneumoniae infections. keywords: comorbidities; infections; mycoplasma; patients; pneumoniae cache: cord-000001-ug7v899j.txt plain text: cord-000001-ug7v899j.txt item: #2 of 2876 id: cord-000083-3p81yr4n author: None title: Poster Exhibition date: 2009-01-31 words: 113010 flesch: 51 summary: From this group of HBV patients 35 (98%) have had elevated urinal Dol excreation (45,8±5,2 g/ml vs . 3% and 47.4 respectively in HCC patients, 60.3% and 39.7 in LC patients, 55% and 40 in CHB patients, 55% and 40 in ACLF patients. keywords: activity; acute; adefovir; adv; afp; age; aim; aims; alt; alt levels; analysis; anti; assay; associated; b virus; background; baseline; blood; cancer; carcinoma; cases; cells; chb patients; china; chronic hcv; chronic hepatitis; clinical; combination; conclusion; control; control group; copies; correlation; data; days; development; diagnosis; difference; dna levels; dose; drug; effect; efficacy; end; etv; expression; factors; fibrosis; follow; gene; genotype; group; group b; hbeag; hbv dna; hbv genotype; hbv infection; hcc cell; hcc patients; hcv; hepatic; hepatitis b; hepatitis patients; hepatocellular; hospital; ifn; increase; infected; lamivudine; levels; liver; liver biopsy; liver cirrhosis; liver disease; load; low; male; markers; mean; median; medical; methods; model; months; mrna; mutation; nafld; negative; non; p<0.05; patients; patients chronic; pcr; positive; prevalence; protein; rate; ratio; rats; recurrence; related; resistance; respectively; response; results; rfa; risk; rna; role; samples; score; seroconversion; serum alt; serum hbv; significant; specific; study; study group; subjects; survival; svr; therapy; time; total; treatment; treatment group; tumor; university; virus; weeks; years cache: cord-000083-3p81yr4n.txt plain text: cord-000083-3p81yr4n.txt item: #3 of 2876 id: cord-000161-hxjxczyr author: Rello, Jordi title: Clinical review: Primary influenza viral pneumonia date: 2009-12-21 words: 3655 flesch: 29 summary: The real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) Swine Flu Panel for detection of pandemic H1N1 influenza, developed by the Centers for Disease Control and Prevention (Atlanta, GA, USA) and distributed to many laboratories in US and worldwide, is a reliable and timely method of diagnosing the pandemic strain [32, 33] . [35] and unacceptably insensitive for the detection of pandemic H1N1 influenza keywords: acute; h1n1; infection; influenza; pandemic; patients; pneumonia; strain; virus cache: cord-000161-hxjxczyr.txt plain text: cord-000161-hxjxczyr.txt item: #4 of 2876 id: cord-000229-9fr0m92p author: Yun, Tae Jin title: Radiological and Clinical Characteristics of a Military Outbreak of Pandemic H1N1 2009 Influenza Virus Infection date: 2010-06-21 words: 3216 flesch: 39 summary: We considered the possibility that co-infection of the pandemic H1N1 2009 influenza virus with other unknown respiratory pathogens under the leukocytopenia status could have attributed to this symptom aggravation (9, 10), particularly as he was a soldier serving in a different unit from the majority of other patients. In this article, we aim to describe detailed clinical characteristics and radiologic features of chest radiographs and thin-section CT findings of patients confirmed with the pandemic H1N1 2009 influenza virus infection occurring in a semi-closed setting. keywords: h1n1; infection; influenza; patients; section; study; virus cache: cord-000229-9fr0m92p.txt plain text: cord-000229-9fr0m92p.txt item: #5 of 2876 id: cord-000268-480d3yfv author: Porfyridis, Ilias title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 words: 4277 flesch: 39 summary: Imaging of pneumonia: trends and algorithms Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia TREM-1(triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses TREM-1 amplifies inflammation and is a crucial mediator of septic shock Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes Clinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsis Triggering receptor expressed on myeloid cells-1 (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients Soluble triggering receptor expressed on myeloid cells-1: a biomarker for bacterial meningitis Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis Soluble triggering receptor expressed on myeloid cells-1(sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease Role of soluble triggering receptor expressed on myeloid cells-1 in inflammatory bowel disease TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by Marburg and ebola viruses Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection The increased expression of TREM-1 on monocytes is associated with infectious and non-infectious inflammatory processes Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and nonsurvivors in the early stage of acute inflammation Prognosis of community acquired pneumonia(CAP): value of triggering receptor expressed on myeloid cells-1 (TREM-1) and other mediators of the inflammatory response Timecourse of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis Diagnosing pneumonia during mechanical ventilation: the clinical pulmonary infection score revisited Infectious Diseases Society of America Guidelines for the management of adult lower respiratory track infections Acute pulmonary embolism focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of chronic heart failure in adults: A Report of the American College of Cardiology Foundation European Respiratory Society international multidisciplinary consensus classification of idiopathic interstitial pneumonias Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome TREM and TREM-like receptors in inflammation and disease The TREM receptor family and signal integration Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells -1(sTREM-1) in the septic host Soluble triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis Soluble triggering receptor expressed on myeloid cells-1 as an antiinflammatory mediator in sepsis Soluble triggering receptor expressed on myeloid cells -1 key: cord-000268-480d3yfv authors: Porfyridis, Ilias; Plachouras, Diamantis; Karagianni, Vasiliki; Kotanidou, Anastasia; Papiris, Spyridon A; Giamarellou, Helen; Giamarellos-Bourboulis, Evangelos J title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 journal: BMC Infect Dis DOI: 10.1186/1471-2334-10-286 sha: doc_id: 268 cord_uid: 480d3yfv BACKGROUND: Differential diagnosis of patients with lung infiltrates remains a challenge. keywords: group; infiltrate; lung; myeloid; patients; pulmonary; receptor; strem-1; study cache: cord-000268-480d3yfv.txt plain text: cord-000268-480d3yfv.txt item: #6 of 2876 id: cord-000284-00rk8fb5 author: Hajjar, L. A. title: Severe novel influenza A (H1N1) infection in cancer patients date: 2010-05-28 words: 3714 flesch: 40 summary: Diagnosis and management of infectious complications in critically ill patients with cancer The epidemiology of sepsis in patients with malignancy Update: novel influenza A (H1N1) virus infection-Mexico Update: swine influenza A (H1N1) infections-California and Texas Emergence of a novel swine-origin influenza A (H1N1) virus in humans Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients Seasonal and pandemic human influenza viruses attach better to human upper respiratory tract epithelium than avian influenza viruses Evaluation of rapid influenza diagnostic tests for detection of novel influenza A (H1N1) Virus -United States Lung pathology in fatal novel human influenza A (H1N1) infection Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer center A/H1N1 flu pandemic. Ann Oncol DOI: 10.1093/annonc/mdq254 sha: doc_id: 284 cord_uid: 00rk8fb5 Background: The natural history and consequences of severe H1N1 influenza infection among cancer patients are not yet fully characterized. keywords: cancer; cases; disease; failure; h1n1; infection; influenza; lung; patients cache: cord-000284-00rk8fb5.txt plain text: cord-000284-00rk8fb5.txt item: #7 of 2876 id: cord-000308-cxr1ul7q author: Cianchi, Giovanni title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date: 2011-01-11 words: 4332 flesch: 38 summary: In our population bleeding also occurred more frequently in ECMO patients, and they required more transfusions compared to non ECMO patients. In case of renal replacement therapy requirement in ECMO patients, a continuous veno-venous hemodiafiltration circuit was assembled on the ECMO circuit (aspiration on pre-pump line, restitution on preoxygenation line). keywords: acute; ecmo; extracorporeal; failure; h1n1; infection; influenza; lung; lus; patients; ventilation cache: cord-000308-cxr1ul7q.txt plain text: cord-000308-cxr1ul7q.txt item: #8 of 2876 id: cord-000457-e50a0suk author: Rhim, Jung-Woo title: Epidemiological and clinical characteristics of childhood pandemic 2009 H1N1 virus infection: an observational cohort study date: 2011-08-24 words: 3749 flesch: 43 summary: Because this pandemic occurred over 40 years after last pandemic (Hong Kong flu), there have been no controlled-clinical trials for the efficacy of corticosteroids on influenza virus infections, although yearly seasonal influenza and small cases of sporadic H5N1 avian influenza virus infection have occurred during inter-pandemic period. Although influenza virus infection has been a major global concern since the pandemic 1918 'Spanish flu', there have been no pandemic influenzas for near four decades after the 1968 'Hong Kong flu'. keywords: h1n1; infection; influenza; pandemic; patients; pneumonia; virus cache: cord-000457-e50a0suk.txt plain text: cord-000457-e50a0suk.txt item: #9 of 2876 id: cord-000522-d498qj2b author: Vincent, Jean-Louis title: Reducing mortality in sepsis: new directions date: 2002-12-05 words: 8718 flesch: 43 summary: Interestingly, this decrease was apparent even before the five interventions discussed in the present article were published, reflecting improvements in the general supportive care of sepsis patients. Generalists have been taught to recognize the signs Sepsis patients often come 'second hand' from a and symptoms of AMI; initial treatment is usually specialist who may not be appropriately trained to provided by emergency physicians, who are trained diagnose, manage, and refer patients with sepsis to treat these patients Mortality prior to hospital discharge in patients receiving a tidal volume of 6 and 12 ml/kg ideal body weight. keywords: alfa; care; drotrecogin; group; icu; interventions; mortality; patients; protein; sepsis; shock; study; therapy; treatment; trial cache: cord-000522-d498qj2b.txt plain text: cord-000522-d498qj2b.txt item: #10 of 2876 id: cord-000716-fhm8abxp author: Wang, Hao title: Analysis on the Pathogenesis of Symptomatic Pulmonary Embolism with Human Genomics date: 2012-07-11 words: 2774 flesch: 38 summary: In addition, we also found that the number of CD3+T cells and CD8+T cells was dramatically reduced in a series of acute PE patients and cytological findings also supported the results from genomics studies on PE patients (27) . Genomic data showed no damage to vascular endothelial cells in PE patients. keywords: analysis; cells; expression; gene; patients; pulmonary; vte cache: cord-000716-fhm8abxp.txt plain text: cord-000716-fhm8abxp.txt item: #11 of 2876 id: cord-000718-7whai7nr author: None title: ESP Abstracts 2012 date: 2012-08-22 words: 166798 flesch: 44 summary: Of those, 11 were also positive for tumor cells on cytological smears. At the papillary thyroid cancer progression matrix metalloprotease and specific tissue inhibitors of metalloprotease (TIMP-2) increased in the cytoplasm of tumor cells, but the concentration of TIMP-1 decreased. keywords: activity; acute; adenocarcinoma; age; aim; alk; amplification; analysis; antibodies; antibody; areas; associated; association; benign; biopsies; biopsy; bladder; blood; bone; braf; breast; breast cancer; breast carcinoma; cadherin; cancer; cancer cases; cancer cell; cancer patients; carcinoma; carcinoma cases; cases; cell carcinoma; cell lung; cell lymphoma; changes; chemotherapy; chronic; clinical; colon; colorectal; conclusion; control; correlation; cystic; cytoplasmic; data; dept; detection; development; diagnosis; diameter; differentiation; diffuse; disease; dna; egfr; epithelial; evaluation; examination; expression; expression levels; factor; features; female; fibrosis; findings; fish; follow; gastric; gene; gene expression; grade; group; growth; her2; high; histological; history; hospital; human; ihc; immunohistochemistry; index; infiltration; inflammation; inflammatory; invasion; invasive; involvement; ki67; kidney; left; lesions; levels; like; literature; liver; loss; lung; lung cancer; lymph; lymphoma; male; malignant; markers; mass; material; mean; median; medical; melanoma; metastases; metastatic; method; molecular; months; morphology; mutation; necrosis; negative; neoplasm; neoplastic; new; node; non; normal; nuclear; nuclei; number; objective; outcome; overexpression; p53; paraffin; parameters; pathology; patients; pattern; pcr; positive; positivity; potential; presence; present; primary; prognostic; progression; proliferation; prostate; protein expression; pulmonary; range; receptor; recurrence; renal; report; resection; respectively; response; results; right; risk; role; samples; sarcoma; score; sections; series; serum; significance; situ; size; skin; specific; specimens; spindle; stage; staining; status; stromal; studies; study; surgery; survival; system; therapy; thyroid; time; tissue; total; treatment; tumor cells; tumor grade; tumor size; tumor tissue; tumors; tumour; turkey objective; type; university; value; vascular; vimentin; women; years cache: cord-000718-7whai7nr.txt plain text: cord-000718-7whai7nr.txt item: #12 of 2876 id: cord-000831-zwfxnd7r author: Bakhshayeshkaram, Mehrdad title: Imaging Findings in Patients With H1N1 Influenza A Infection date: 2011-12-25 words: 2286 flesch: 49 summary: Pandemic (H1N1) Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus (S-OIV) infection H1N1 influenza Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China H1N1 influenza: initial chest radiographic findings in helping predict patient outcome High-resolution computed tomography findings from adult patients with Influenza A (H1N1) virus-associated pneumonia Do pulmonary radiographic findings at presentation predict mortality in patients with community-acquired pneumonia? key: cord-000831-zwfxnd7r authors: Bakhshayeshkaram, Mehrdad; Saidi, Bahareh; Tabarsi, Payam; Zahirifard, Soheila; Ghofrani, Mishka title: Imaging Findings in Patients With H1N1 Influenza A Infection date: 2011-12-25 journal: Iran J Radiol DOI: 10.5812/iranjradiol.4554 sha: doc_id: 831 cord_uid: zwfxnd7r BACKGROUND: keywords: h1n1; infection; influenza; lung; patients cache: cord-000831-zwfxnd7r.txt plain text: cord-000831-zwfxnd7r.txt item: #13 of 2876 id: cord-000843-e1bn79ui author: None title: ECR 2011 Book of Abstracts - A - Postgraduate Educational Programme date: 2011-03-01 words: 91300 flesch: 40 summary: Both conditions are easily discernible with CT imaging. CT perfusion imaging is a quantitative technique that employs rapid sequences of CT images after bolus administration of intravenous contrast material to measure a range of physiological processes related to the microvasculature of tissues. keywords: acute; approach; assessment; benign; bone; brain; breast imaging; cancer; cardiac; cases; cause; changes; chest; children; complications; conditions; contrast; ct imaging; data; detection; development; diagnosis; differential; diffusion; disease; dose; evaluation; examination; field; findings; follow; functional; images; imaging; imaging features; imaging findings; imaging methods; imaging modality; imaging protocols; imaging techniques; information; knowledge; learning; lecture; lesions; liver; lung; management; mass; medical; modalities; mr imaging; mri; need; new; non; objectives; patients; pelvic; perfusion; perfusion imaging; pet; post; potential; practice; presentation; primary; procedures; pulmonary; quality; radiation; radiological; radiologist; radiology; resolution; resonance imaging; response; results; review; risk; role; screening; sensitivity; sequences; signal; staging; studies; surgery; system; therapy; time; tissue; treatment; tumour; ultrasound; use; vascular; years cache: cord-000843-e1bn79ui.txt plain text: cord-000843-e1bn79ui.txt item: #14 of 2876 id: cord-000891-5r2in1gw author: Giannella, Maddalena title: Should lower respiratory tract secretions from intensive care patients be systematically screened for influenza virus during the influenza season? date: 2012-06-14 words: 4120 flesch: 39 summary: Multivariate analysis showed admission to the surgical ICU (odds ratio (OR), 37.1; 95% confidence interval (CI), 2.1 to 666.6; P = 0.01) and localized infiltrate on chest radiograph (OR, 27.8; 95% CI, 1.3 to 584.1; P = 0.03) to be independent risk factors for unsuspected influenza. A logistic binary model was used to analyze the independent risk factors for unsuspected influenza and 30-day mortality. keywords: admission; cases; diagnosis; hospital; icu; influenza; pandemic; patients; samples cache: cord-000891-5r2in1gw.txt plain text: cord-000891-5r2in1gw.txt item: #15 of 2876 id: cord-000904-g6ffaer1 author: Ni, Hong title: Sorafenib Combined with Cryoablation to Treat Unresectable Hepatocellular Carcinoma date: 2011-09-17 words: 3455 flesch: 42 summary: Cryoablation combined with sorafenib demonstrates good efficacy and acceptable tolerability in treating unresectable advanced HCC patients. Cryoablation in combination with percutaneous ethanol ablation has been shown by Xu, et al. to be a viable alternative treatment method for HCC patients with large, and unresectable tumors. keywords: cryoablation; hcc; months; patients; sorafenib; study; treatment; tumor cache: cord-000904-g6ffaer1.txt plain text: cord-000904-g6ffaer1.txt item: #16 of 2876 id: cord-000977-ka4261wc author: None title: ECR 2013 Book of Abstracts - B - Scientific Sessions date: 2013-03-07 words: 133260 flesch: 46 summary: Attenuation of anode heel effect with an aluminum filter and their influence on patient dose in lumbar spine radiography J. Soares, R. Dores, P. Sousa, S.I. Rodrigues, L.P.V. Ribeiro, A.F.C.L. Abrantes, R.P.P. Almeida; The aim of this study is to functionally map VWFA at the individual subject level using frequent words of the Portuguese lexicon, to develop a paradigm potentially useful for clinical patients. keywords: accuracy; acquisition; adc; agreement; aim; algorithm; analysis; angiography; arterial; arteries; artery; assessment; associated; attenuation; average; baseline; benign; blood; body; bone; brain; breast; cad; cancer; cancer patients; cardiac; cases; changes; comparison; conclusion; contrast; control; coronary; correlation; ct images; data; density; detection; diagnostic; diameter; differences; diffusion; digital; disease; dose; dose ct; dwi; enhancement; evaluation; examinations; exposure; fat; fbp; fdg; findings; flow; follow; function; good; group; high; image; image quality; imaging; increase; injection; length; lesions; levels; linear; liver; low; lung; mammography; materials; mdct; mean; measurements; methods; model; months; mri; negative; nodules; noise; non; normal; number; parameters; patients; performance; perfusion; pet; phantom; phase; point; post; potential; pre; procedure; protocol; pulmonary; purpose; quality; radiation; radiographers; radiologists; range; rate; ratio; ray; readers; reconstruction; reduction; reference; renal; resolution; response; results; risk; scale; scans; score; screening; sensitivity; sequences; signal; size; slice; snr; software; specificity; standard; studies; study; subjects; surgery; system; t mri; technique; test; therapy; time; tissue; total; treatment; tumour; ultrasound; underwent; use; values; vessel; volume; weighted; women; years cache: cord-000977-ka4261wc.txt plain text: cord-000977-ka4261wc.txt item: #17 of 2876 id: cord-001078-5m29nugu author: Chen, Xiaorong title: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study date: 2013-09-17 words: 3948 flesch: 43 summary: C-reactive protein level might be used as an early marker for clinical prognosis in H7N9 patients based on results from our logistic regression analyses, which was in agreement with previous studies showing that C-reactive protein level might serve as a marker for severity of illness in influenza infections [18, 19] . Elderly people may have increased risk for H7N9 virus infection. keywords: avian; group; h7n9; infection; influenza; patients; therapy; treatment; virus cache: cord-001078-5m29nugu.txt plain text: cord-001078-5m29nugu.txt item: #18 of 2876 id: cord-001154-7k59ogn0 author: Memoli, Matthew J. title: The Natural History of Influenza Infection in the Severely Immunocompromised vs Nonimmunocompromised Hosts date: 2013-11-01 words: 3914 flesch: 26 summary: Immunocompromised patients with influenza had more severe disease/complications, longer viral shedding, and more antiviral resistance while demonstrating less clinical symptoms and signs on clinical assessment. Immunocompromised patients are at risk for more severe or complicated influenza induced disease, which may be difficult to prevent with existing vaccines and antiviral treatments. keywords: group; individuals; infection; influenza; patients; resistance; study; symptoms; virus cache: cord-001154-7k59ogn0.txt plain text: cord-001154-7k59ogn0.txt item: #19 of 2876 id: cord-001221-due9tloa author: None title: ECR 2014, Part A date: 2014-02-27 words: 107894 flesch: 38 summary: On CT imaging, thermal ablation areas are well circumscribed and oval shaped. MR imaging allows earlier detection of residual liver tumour than CT imaging. keywords: ablation; acute; analysis; approach; assessment; benign; biopsy; body; bone; brain; brain imaging; breast imaging; cancer; cardiac; care; cases; changes; children; complex; complications; conditions; contrast; coronary; criteria; ct imaging; current; data; detection; development; diagnosis; differential; diffusion; disease; dose; e.g.; enhancement; evaluation; evidence; examination; fat; features; follow; functional; help; high; image; imaging; imaging biomarkers; imaging criteria; imaging features; imaging findings; imaging methods; imaging modalities; imaging techniques; importance; inflammatory; information; interventional; key; knowledge; learning; lecture; lesions; liver; lung; malignant; management; modality; mr imaging; mri; need; new; non; number; objectives; patients; perfusion imaging; pet; pitfalls; post; potential; practice; presentation; procedures; protocols; pulmonary; quality; radiation; radiologists; radiology; research; resonance imaging; response; results; risk; role; session; size; specific; staging; standard; stroke; studies; study; surgery; systems; therapy; time; tissue; treatment; tumour; tumour imaging; ultrasound; use; value; vascular; years cache: cord-001221-due9tloa.txt plain text: cord-001221-due9tloa.txt item: #20 of 2876 id: cord-001293-dfaxj3bv author: Cavaillon, Jean-Marc title: Is boosting the immune system in sepsis appropriate? date: 2014-03-24 words: 6247 flesch: 27 summary: The clinical observations used to argue that immunosuppression occurs in sepsis patients surviving the initial inflammatory cascade These are all organisms of normal virulence that cause nosocomial infections in sepsis patients because of the selection pressure of potent antibiotics and the presence of biofilm affected/colonized intravascular and urinary catheters. keywords: apoptosis; cells; cytokine; expression; immune; infection; mice; model; murine; patients; production; response; sepsis; tnf cache: cord-001293-dfaxj3bv.txt plain text: cord-001293-dfaxj3bv.txt item: #21 of 2876 id: cord-001313-f72hl6du author: Toncheva, D. title: NGS Nominated CELA1, HSPG2, and KCNK5 as Candidate Genes for Predisposition to Balkan Endemic Nephropathy date: 2014-05-15 words: 3657 flesch: 35 summary: There is no statistically significant difference between annotated variants in BEN patients and European populations. Mutant genes (CELA1, HSPG2, and KCNK5) in BEN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis. keywords: balkan; ben; cela1; cells; disease; endemic; genes; nephropathy; patients; variants; vascular cache: cord-001313-f72hl6du.txt plain text: cord-001313-f72hl6du.txt item: #22 of 2876 id: cord-001322-7xmxcm35 author: Walden, Andrew P title: Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort date: 2014-04-01 words: 4294 flesch: 41 summary: In one study, the death rate of ICU patients between 28 days and 6 months was 9% in patients with sepsis, similar to the 8% seen in ICU patients without sepsis [36] and the 10% found in the present study. This compares to an increase in mortality from 18.2% at 30 days to 24.8% at 90 days in the subgroup of ICU patients in the PORT study [24] and an increase from 17.3% to 34.8% at 12 months in the GenIMS cohort of ICU patients [3] . keywords: cap; community; icu; mortality; outcome; patients; pneumonia; severe; study cache: cord-001322-7xmxcm35.txt plain text: cord-001322-7xmxcm35.txt item: #23 of 2876 id: cord-001421-6t5puo6p author: Marfà, Santiago title: Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease date: 2014-10-02 words: 5059 flesch: 42 summary: Fibrosis scores and liver function tests of the two groups of fibrotic patients were similar to those obtained in HCV LT patients. The methods currently available to assess liver fibrosis include the serological determination of several parameters related to liver function and hepatic remodeling, imaging techniques, such as Fibroscan or ARFI and the use of invasive procedures such as HVPG measurement or liver biopsy, the latter still being the most widely accepted gold standard method for assessing liver fibrosis [9] . keywords: fibrinogen; fibrosis; hcv; kda; liver; non; patients; peak; protein; recurrent; samples; serum cache: cord-001421-6t5puo6p.txt plain text: cord-001421-6t5puo6p.txt item: #24 of 2876 id: cord-001493-3yu2di1g author: Fujishima, Seitaro title: Pathophysiology and biomarkers of acute respiratory distress syndrome date: 2014-05-07 words: 3099 flesch: 31 summary: In the revised Berlin definition, the term ARDS was redefined as a broader concept including a milder condition of lung injury; therefore, it became equivalent to acute lung injury (ALI), which was the previous AECC definition. Persistent elevation over time predicts poor outcome Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials National Heart Blood, and Lung Institute Acute Respiratory Distress Syndrome Network: Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome Keratinocyte growth factor and hepatocyte growth factor in bronchoalveolar lavage fluid in acute respiratory distress syndrome patients Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients Neutrophil elastase and systemic inflammatory response syndrome in the initiation and development of acute lung injury among critically ill patients Role of diabetes in the development of acute respiratory distress syndrome* Diabetes, insulin, and development of acute lung injury Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferatoractivated receptor-{gamma} Hartl D: CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation DNA and inflammatory mediators in bronchoalveolar lavage fluid from children with acute inhalational injuries Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury Soluble form of P-selectin in plasma is elevated in acute lung injury Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure Acute Respiratory Distress Syndrome Network: keywords: acute; ards; biomarkers; injury; levels; lung; patients; respiratory cache: cord-001493-3yu2di1g.txt plain text: cord-001493-3yu2di1g.txt item: #25 of 2876 id: cord-001536-ta1i0ata author: Nair, Girish B title: Year in review 2013: critical care - respiratory infections date: 2014-10-29 words: 8910 flesch: 34 summary: In another study, including 350 patients, investigators using data from electronic medical records compared the incidence and outcomes in VAP patients using various definitions, including the new CDC ventilator-associated event algorithm, before and after a VAP bundle was introduced in their institution (pre-bundle period January 2003 to December 2006 (n = 213); post-bundle period January 2007 to December 2009 (n = 137)) As with the previous study, VAP patients with susceptible PA received adequate empiric antibiotic coverage more often, both empiric and definitive, than patients with MDR pathogens (68% versus 30%, P <0.001). keywords: antibiotic; icu; infection; mortality; pathogens; patients; pneumonia; risk; sepsis; study; therapy; vap; ventilator cache: cord-001536-ta1i0ata.txt plain text: cord-001536-ta1i0ata.txt item: #26 of 2876 id: cord-001617-ff3j7i7i author: Siqueira, André M title: Characterization of Plasmodium vivax-associated admissions to reference hospitals in Brazil and India date: 2015-03-20 words: 7195 flesch: 32 summary: We have used a common protocol in order to prospectively follow vivax malaria patients admitted to two distinct reference centers located in Brazil and India, aiming to comprehensively characterize and compare the clinical complications of P. vivax infection. Admission is free of charge, and admission criteria for malaria patients are any clinical complications suggestive of severe malaria, or complications impacting proper antimalarial treatment, such as severe vomiting. keywords: clinical; complications; criteria; health; infection; malaria; manaus; p. vivax; patients; plasmodium; study; vivax cache: cord-001617-ff3j7i7i.txt plain text: cord-001617-ff3j7i7i.txt item: #27 of 2876 id: cord-001661-dj9bxhwb author: Kao, Kuo-Chin title: Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy date: 2015-05-15 words: 4386 flesch: 42 summary: Pathological findings of DAD patients had a higher hospital mortality rate than non-DAD patients (71.9 % vs 45.5 %, p = 0.007). A pathological finding of DAD in ARDS patients is associated with hospital mortality and there are no clinical characteristics that could identify DAD patients before open lung biopsy. keywords: acute; ards; biopsy; dad; distress; lung; patients; study; syndrome cache: cord-001661-dj9bxhwb.txt plain text: cord-001661-dj9bxhwb.txt item: #28 of 2876 id: cord-001879-bn7h0kcw author: Papiris, Spyros A title: Survival in Idiopathic pulmonary fibrosis acute exacerbations: the non-steroid approach date: 2015-12-14 words: 4864 flesch: 37 summary: Avoiding steroids in IPF patients may favor the natural history of the disease even at the moment of its most devastating event. In 2012 a randomized, double-blind, placebo-controlled trial based on an independent protocol reviewed by a committee appointed by the National Heart, Lung, and Blood Institute, and conducted in 25 clinical centers under the auspices of the Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet) was terminated prematurely when the interim analysis demonstrated that IPF patients treated with combination therapy with prednisone, azathioprine and N-acetylcysteine not only had no evidence of physiological or clinical benefit but presented significantly increased rate of hospitalizations, exacerbations and deaths compared to the placebo arm [5] . keywords: acute; exacerbation; fibrosis; ipf; patients; steroids; survival cache: cord-001879-bn7h0kcw.txt plain text: cord-001879-bn7h0kcw.txt item: #29 of 2876 id: cord-002145-yq7iwp42 author: Ibrahim, Ahmed title: Clinical profile and outcome of patients with acute kidney injury requiring dialysis—an experience from a haemodialysis unit in a developing country date: 2016-07-22 words: 2713 flesch: 48 summary: The relatively young age of patients is consistent with results from other parts of Africa and can be explained by the predominantly young overall population demographics of most Sum is more than 100 % as most patients had more than one indication for dialysis sub-Saharan countries from which similar researches were done [3, 4] . This study is the first of its kind to describe the etiology and clinical profile of AKI patients requiring dialysis in Ethiopia. keywords: acute; aki; causes; dialysis; patients; study cache: cord-002145-yq7iwp42.txt plain text: cord-002145-yq7iwp42.txt item: #30 of 2876 id: cord-002240-38aabxh1 author: Prina, Elena title: New aspects in the management of pneumonia date: 2016-10-01 words: 4835 flesch: 30 summary: Immunomodulatory effects of macrolides during community-acquired pneumonia: a literature review Antibiotic treatment strategies for community-acquired pneumonia in adults beta-Lactam monotherapy vs beta-lactam-macrolide combination treatment in moderately severe community-acquired pneumonia: a randomized noninferiority trial Efficacy of increasing dosages of clarithromycin for treatment of experimental Mycoplasma pneumoniae pneumonia Lung inflammatory pattern and antibiotic treatment in pneumonia Systemic corticosteroids for community-acquired pneumonia: reasons for use and lack of benefit on outcome Systemic inflammatory pattern of community-acquired pneumonia (CAP) patients with and without chronic obstructive pulmonary disease (COPD) Inhaled corticosteroids and systemic inflammatory response in community-acquired pneumonia: a prospective clinical study Pneumonic and non-pneumonic exacerbations of COPD: systemic inflammatory response and clinical characteristics Immunomodulatory effects of quinolones Assessment of plasmatic immunoglobulin G, A and M levels in septic shock patients Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia Pooled human immunoglobulin therapy in critically Ill patients with pandemic 2009 influenza A(H1N1) pneumonitis and immunoglobulin G2 subclass (IgG2) deficiency Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock Intravenous immunoglobulin and mortality in pneumonia patients with septic shock: an observational nationwide study Concept for a study design in patients with severe community-acquired pneumonia: a randomised controlled trial with a novel IGM-enriched immunoglobulin preparation-The CIGMA study Not applicable. In particular, high levels of interleukin (IL)-6, IL-8, and IL-10 have been detected in patients with severe pneumonia and excess IL-6 and IL-10 was associated with increased mortality (from 4.8 to 11.4 %) keywords: cap; community; corticosteroids; effects; mortality; patients; pneumonia; treatment; use cache: cord-002240-38aabxh1.txt plain text: cord-002240-38aabxh1.txt item: #31 of 2876 id: cord-002294-qa8e90qv author: Hayakawa, Sho title: Efficacy of recombinant human soluble thrombomodulin for the treatment of acute exacerbation of idiopathic pulmonary fibrosis: a single arm, non-randomized prospective clinical trial date: 2016-11-07 words: 4530 flesch: 45 summary: The administration of recombinant human soluble thrombomodulin (rhTM), which has both anti-inflammatory and anticoagulant activities, improves outcomes and respiratory function in patients with acute respiratory distress syndrome. Therefore, we conducted a prospective clinical study to examine the effects of rhTM on respiratory function, coagulation markers, and outcomes for patients with AE-IPF. keywords: day; group; ipf; patients; rhtm; study; thrombomodulin; treatment cache: cord-002294-qa8e90qv.txt plain text: cord-002294-qa8e90qv.txt item: #32 of 2876 id: cord-002514-pp06m5xk author: Venkatesan, Sudhir title: Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza A(H1N1)pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis date: 2017-05-15 words: 4020 flesch: 36 summary: This was confirmed in recent IPD analysis of seasonal influenza patients that reported a risk reduction of 63% in treated patients (intention-to-treat infected population) These data suggest that community patients with severe influenza should receive NAI treatment. to 2009 also suggests that NAIs given to high-risk community patients with influenza may reduce subsequent hospitalization keywords: community; data; hospitalization; influenza; nai; patients; study; treatment cache: cord-002514-pp06m5xk.txt plain text: cord-002514-pp06m5xk.txt item: #33 of 2876 id: cord-002626-jzwwses4 author: Kaul, Karen L. title: The Case for Laboratory Developed Procedures: Quality and Positive Impact on Patient Care date: 2017-07-16 words: 14833 flesch: 34 summary: [79] [80] [81] Instrumentation from Thermo Fisher (Thermo Fisher Life-Technologies, Carlsbad, CA, USA) and Illumina (Illumina, San Diego, CA, USA), the Personal Genome Machine (PGM), and MiSeq, have made NGS suitable for routine clinical laboratory testing. Laboratory testing for FX includes sizing the number of repeats as well as methylation analysis and has been available for clinical diagnostic and carrier status testing for over 20 years. keywords: assays; braf; cancer; care; clinical; data; diagnosis; disease; fda; gene; guidelines; laboratories; laboratory; ldps; methods; mutations; new; patients; performance; quality; results; risk; sequencing; testing; tests; therapy; treatment; use; virus cache: cord-002626-jzwwses4.txt plain text: cord-002626-jzwwses4.txt item: #34 of 2876 id: cord-002724-gtv9syzi author: Pfortmueller, Carmen Andrea title: Assessment of immune organ dysfunction in critical illness: utility of innate immune response markers date: 2017-10-23 words: 6203 flesch: 29 summary: Diagnostic and predictive value of circulating activated T cells Reduced monocyte HLA-DR expression: a novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure Predictive value of interleukins 6, 8 and 10, and low HLA-DR expression in acute renal failure Predicting post-stroke infections and outcome with blood-based immune and stress markers Decreased monocyte HLA-DR expression in patients after non-shockable out-of-hospital cardiac arrest Immune responses after acute ischemic stroke or myocardial infarction Heart failure and kidney dysfunction: epidemiology, mechanisms and management Leukocyte redistribution: effects of beta blockers in patients with chronic heart failure The ins and outs of MHC class II-mediated antigen processing and presentation Monocyte human leukocyte antigen-DR transcriptional downregulation by cortisol during septic shock Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysis Monocyte deactivation in septic patients: restoration by IFN-gamma treatment Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients A high frequency of MDSCs in sepsis patients, with the granulocytic subtype dominating in gram-positive cases Early expansion of circulating granulocytic myeloid-derived suppressor cells predicts development of nosocomial infections in patients with sepsis Human myeloid-derived suppressor cells are associated with chronic immune suppression after severe sepsis/septic shock Apoptosis-induced lymphopenia in sepsis and other severe injuries Interleukin-6: an overview Point-of-care testing for interleukin-6 in cerebro spinal fluid (CSF) after subarachnoid haemorrhage Interleukin-6 serum level assessment using a new qualitative point-of-care test in sepsis: a comparison with ELISA measurements However, it should be noted that they do not reflect immune cell functionality as cytokines are mostly pleiotropic, derived from different cells including non-immune cells, may be counteracted by natural inhibitors (e.g., gp130 for IL-6), and have variable clearance rates [4, 6, 11, 12] . keywords: antigen; cells; dr expression; expression; immune; immunosuppression; injury; mhla; mortality; patients; sepsis cache: cord-002724-gtv9syzi.txt plain text: cord-002724-gtv9syzi.txt item: #35 of 2876 id: cord-002757-upwe0cpj author: Sullivan, Kathleen E. title: Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies date: 2017-08-07 words: 24227 flesch: 37 summary: Importantly, after a novel PIDD has been described, subsequent reports often reveal a wider variation in associated infections and cellular findings, often without clear genotype-phenotype correlations [320] [321] Human infection, called Cat Scratch Disease, is assumed to involve inoculation of Bartonella-infected flea feces into the skin during a cat scratch. keywords: associated; azole; bartonella; cases; cause; cell; children; chronic; clinical; cns; countries; days; deficiency; dengue; diagnosis; disease; epidemiology; fever; hiv; human; immune; immunodeficiency; immunoglobulin; individuals; infection; influenza; mandrillaris; patients; pcr; pidd; primary; resistance; review; risk; skin; species; susceptibility; symptoms; syndrome; therapy; tick; transmission; treatment; vaccination; vaccine; virus cache: cord-002757-upwe0cpj.txt plain text: cord-002757-upwe0cpj.txt item: #36 of 2876 id: cord-002774-tpqsjjet author: None title: Section II: Poster Sessions date: 2017-12-01 words: 83566 flesch: 48 summary: The CHIP framework drives the complex inter-relationships between community-hospital engagement, reciprocal capacity-building, integration initiatives, and community-based research and evaluation, to create an interconnected network of health care services. Those living in urban centers should have the best ava1l~b1hty, chmce, and access to a variety of health care services because of the distribution of health care services, fac1lmes, and health professionals in concentrated in urban centers. keywords: access; address; age; aids; analysis; approach; areas; barriers; canada; cancer; care services; care system; case; child health; children; cities; city; clients; clinic; communities; community health; community services; conclusion; conditions; current; data; demographic; depression; development; disease; drug; education; effects; environmental; ethnic; experience; factors; family; findings; focus; food; government; group; health care; health centre; health education; health information; health insurance; health issues; health needs; health outcomes; health policy; health problems; health promotion; health research; health services; health status; health survey; health system; healthcare; help; hiv; homeless; hospital; housing; immigrants; impact; income; individuals; information; interventions; interviews; introduction; issues; key; knowledge; lack; level; life; living; low; medical; methods; model; mortality; national; neighborhood; new; non; number; paper; participants; patients; people; physical; poor; population; population health; poster; poverty; prevalence; prevention; primary; process; program; project; provide; providers; public; quality; rates; relationship; research; residents; resources; results; risk; role; sample; self; sessions; sexual; social; strategies; street; street health; studies; study; substance; support; survey; system; time; toronto; treatment; urban; use; users; women; work; workers; years; youth cache: cord-002774-tpqsjjet.txt plain text: cord-002774-tpqsjjet.txt item: #37 of 2876 id: cord-002782-mena480g author: Chen, Jiajia title: Long term outcomes in survivors of epidemic Influenza A (H7N9) virus infection date: 2017-12-08 words: 3055 flesch: 51 summary: However, there are no previous reports on the quality of life of H7N9 patients after hospital discharge. ARDS patients tended to stay longer in the hospital than non-ARDS patients. keywords: ards; follow; lung; patients; study; survivors cache: cord-002782-mena480g.txt plain text: cord-002782-mena480g.txt item: #38 of 2876 id: cord-002853-vj8t28hn author: Joffe, Michael title: Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient date: 2018-01-27 words: 2131 flesch: 37 summary: There are several well-known risk factors for severe adenovirus infections, including: allogeneic stem cell (or solid-organ) transplantation, particularly with T-cell depletion; treatment with anti-CD52 monoclonal antibody (alemtuzumab or Campath) or anti-thymocyte globulin (ATG); severe immunosuppression used to treat graft-versus-host disease; and any other cause of severe lymphopaenia that reduces the ability of the host's cell-mediated immunity to defend against adenovirus infection [1] . key: cord-002853-vj8t28hn authors: Joffe, Michael; Wagner, Simon D.; Tang, Julian W. title: Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient date: 2018-01-27 journal: BMC Infect Dis DOI: 10.1186/s12879-018-2962-7 sha: doc_id: 2853 cord_uid: vj8t28hn BACKGROUND: keywords: adenovirus; blood; infection; patient; treatment cache: cord-002853-vj8t28hn.txt plain text: cord-002853-vj8t28hn.txt item: #39 of 2876 id: cord-002956-e5ihpe4i author: Chang, Ya-Chun title: Ventilator Dependence Risk Score for the Prediction of Prolonged Mechanical Ventilation in Patients Who Survive Sepsis/Septic Shock with Respiratory Failure date: 2018-04-04 words: 4670 flesch: 41 summary: Ondine's curse: a clinical case and review Respiratory dysfunction in stroke Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression Beyond thrombosis: the versatile platelet in critical illness The role of platelets in sepsis Understanding platelet dysfunction in sepsis Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study Breathing pattern in weaning patients: comparison of two inspired oxygen fractions Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients Immune profiles and clinical outcomes between sepsis patients with or without active cancer requiring admission to intensive care units Impact of clinical severity index, infective pathogens, and initial empiric antibiotic use on hospital mortality in patients with ventilator-associated pneumonia Predictors of prolonged weaning and survival during ventilator weaning in a respiratory ICU A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: We also found the AUC of ventilator dependence risk score was 0.745 in the cancer group and p-value was 0.009. keywords: day; dependence; patients; risk; score; sepsis; study; ventilator; ventilator dependence cache: cord-002956-e5ihpe4i.txt plain text: cord-002956-e5ihpe4i.txt item: #40 of 2876 id: cord-002977-o0dvwzxk author: Gosangi, Babina title: Review of targeted therapy in chronic lymphocytic leukemia: what a radiologist needs to know about CT interpretation date: 2018-04-18 words: 5473 flesch: 32 summary: Cancer stat factschronic lymphocytic leukemia NCCN guidelines insights: chronic lymphocytic leukemia/small lymphocytic leukemia, version 1 Chronic lymphocytic leukemia (CLL)-then and now Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for chronic lymphocytic leukemia Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions Economic burden of chronic lymphocytic leukemia in the era of oral targeted therapies in the United States Genomic aberrations and survival in chronic lymphocytic leukemia Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia Clinical staging of chronic lymphocytic leukemia A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis Abdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia Five years of experience with rituximab plus high-dose dexamethasone for relapsed/refractory chronic lymphocytic leukemia 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis Bilateral occipital lobe invasion in chronic lymphocytic leukemia Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemia Richter transformation of chronic lymphocytic leukemia: a review of fluorodeoxyglucose positron emission tomography-computed tomography and molecular diagnostics Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia Minimal residual disease assessment improves prediction of outcome in patients with Chronic Lymphocytic CLL) who achieve partial response: comprehensive analysis of two phase III studies of the German CLL study group Entering the era of targeted therapy for chronic lymphocytic leukemia: impact on the practicing clinician Rituximab: mechanism of action Rituximab: a new therapeutic monoclonal antibody for non-Hodgkin's lymphoma Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial Rituximab-induced lung disease: a systematic literature review Rituximab-induced interstitial lung disease Interstitial pneumonitis related to rituximab therapy Fulminant B hepatitis in a surface antigen-negative patient with B-cell chronic lymphocytic leukaemia after rituximab therapy Long-term survival in a patient with progressive multifocal leukoencephalopathy after therapy with rituximab, fludarabine and cyclophosphamide for chronic lymphocytic leukemia Alemtuzumab in chronic lymphocytic leukemia First-line treatment of chronic lymphocytic leukemia: role of alemtuzumab FDA drug approval summary: alemtuzumab as single-agent treatment for B-cell chronic lymphocytic leukemia Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia Infectious toxicity using alemtuzumab Cytomegalovirus pneumonia: high-resolution CT findings in ten non-AIDS immunocompromised patients Intestinal disease in acquired immunodeficiency: evaluation by CT Ofatumumab: a novel, fully human anti-CD20 monoclonal antibody for the treatment of chronic lymphocytic leukemia Ofatumumab maintenance versus observation in relapsed chronic lymphocytic leukaemia (PROLONG): an open-label, multicentre, randomised phase 3 study Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, openlabel phase 3 trial Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study Pulmonary toxicities from targeted therapies: a review Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma Detection of cases of progressive multifocal leukoencephalopathy associated with new biologicals and targeted cancer therapies from the FDA's adverse event reporting system Targeting B-cell receptor signaling for anticancer therapy: the Bruton's tyrosine kinase inhibitor ibrutinib induces impressive responses in B-cell malignancies Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia Atrial fibrillation in CLL patients treated with ibrutinib. An international retrospective study How I treat CLL patients with ibrutinib Successful treatment of ibrutinibassociated central nervous system hemorrhage with platelet transfusion support Ibrutinib-induced pneumonitis in patients with chronic lymphocytic leukemia Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib Clinical picture of pneumocystis jiroveci pneumonia in cancer patients Invasive aspergillosis with pulmonary and central nervous system involvement during ibrutinib therapy for relapsed chronic lymphocytic leukaemia: case report PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma Idelalisib-related pneumonitis Idelalisib-associated colitis: histologic findings in 14 patients Management of adverse events associated with idelalisib treatment: expert panel opinion ESCMID Study group for infections in Compromised Hosts (ESGICH) consensus document on the safety of targeted and biological therapies: an infectious diseases perspective (Intracellular signaling pathways: tyrosine kinase and mTOR inhibitors) Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study keywords: chronic; cll; ibrutinib; leukemia; patients; phase; rituximab; therapy; treatment cache: cord-002977-o0dvwzxk.txt plain text: cord-002977-o0dvwzxk.txt item: #41 of 2876 id: cord-003011-vclnb0eh author: de Almeida, Carlos Podalirio Borges title: Predictors of In-Hospital Mortality among Patients with Pulmonary Tuberculosis: A Systematic Review and Meta-analysis date: 2018-05-08 words: 2834 flesch: 39 summary: Available at: www.who Tuberculosis in hospitalized patients: clinical characteristics of patients receiving treatment within the first 24 h after admission Time delays in diagnosis of pulmonary tuberculosis: a systematic review of literature Hospitalizations for tuberculosis in the United States in 2000: predictors of in-hospital mortality Quality of life in tuberculosis: patient and provider perspectives The impact of comorbidity on mortality following in-hospital diagnosis of tuberculosis Experience with a medical-psychosocial inpatient unit Delay in diagnosis among hospitalized patients with active tuberculosis-predictors and outcomes The impact of nutritional deficit on mortality of in-patients with pulmonary tuberculosis Diabetes is a strong predictor of mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients from Mwanza, Tanzania Impact of diabetes and smoking on mortality in tuberculosis Diabetes mellitus is associated with increased mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients in South-Eastern Amahra Region A review of sex differences in the epidemiology of tuberculosis Social and cultural dimensions of gender and tuberculosis Mortality among MDR-TB cases: comparison with drug-susceptible tuberculosis and associated factors Differences between Risk Factors Associated with Tuberculosis Treatment Abandonment and Mortality Independent predictors of tuberculosis mortality in a high HIV prevalence setting: a retrospective cohort study Initial presentations predict mortality in pulmonary tuberculosis patients-a prospective observational study Tuberculosis mortality: patient characteristics and causes Excess mortality due to tuberculosis and factors associated to death in and annual cohort of patients diagnosed of tuberculosis Predictors of in-hospital mortality among patients with pulmonary tuberculosis: a protocol of systematic review and meta-analysis of observational studies The measurement of observer agreement for categorical data The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analyses. Conclusion: Co-morbid malignancy was associated with increased risk of in-hospital death among pulmonary TB patients. keywords: hospital; mortality; patients; quality; study; tuberculosis cache: cord-003011-vclnb0eh.txt plain text: cord-003011-vclnb0eh.txt item: #42 of 2876 id: cord-003198-1kw5v6rm author: Vuillard, Constance title: Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study date: 2018-09-11 words: 4860 flesch: 36 summary: 22 Service de Réanimation médicale Unité de Réanimation et de Surveillance continue, Service de Pneumologie et Réanimation médicale, Groupe hospitalier Pitié-Salpêtrière, 47-83 bd de l'hôpital A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients Do we need ARDS? Acute respiratory distress syndrome mimickers lacking common risk factors of the Berlin definition Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study Acute respiratory distress syndrome: the Berlin definition Diagnostic workup for ARDS patients Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset Dermato-pulmonary syndrome associated with MDA-5 antibodies A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature. Antisynthetase syndrome Clinical and serological aspects of patients with anti-Jo-1 antibodies-an evolving spectrum of disease manifestations Myositis specific autoantibodies: changing insights in pathophysiology and clinical associations Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes Clinical manifestations and outcome of anti-PL7 positive patients with antisynthetase syndrome Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis Comparison of long-term outcome between anti-Jo1-and anti-PL7/PL12 positive patients with antisynthetase syndrome The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study Clinical features and outcomes of interstitial lung disease in anti-Jo-1 positive antisynthetase syndrome Acute respiratory failure in critically ill patients with interstitial lung disease Idiopathic pulmonary fibrosis: predicting response to therapy and survival Idiopathic pulmonary fibrosis: a composite physiologic index derived from disease extent observed by computed tomography Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy The role of open-lung biopsy in ARDS keywords: acute; amda-5; anti; dermato; icu; lung; patients; pulmonary; syndrome cache: cord-003198-1kw5v6rm.txt plain text: cord-003198-1kw5v6rm.txt item: #43 of 2876 id: cord-003219-iryb3v0z author: Kao, Kuo-Chin title: Predictors of survival in patients with influenza pneumonia-related severe acute respiratory distress syndrome treated with prone positioning date: 2018-09-24 words: 4380 flesch: 41 summary: [16] studied H7N9 influenza patients with prone positioning, and decrease in carbon dioxide retention was noted, but no clinical outcome was mentioned. Our previous study for severe ARDS patients with ECMO revealed that higher dynamic driving pressure [hazard ratio 1.070 (1.026-1.116), p = 0.002] during the first 3 days of ECMO was one of the factors independently associated with ICU mortality keywords: acute; ards; driving; influenza; patients; pneumonia; positioning; pressure; study cache: cord-003219-iryb3v0z.txt plain text: cord-003219-iryb3v0z.txt item: #44 of 2876 id: cord-003291-zuqx6ksy author: Tang, Pingping title: Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review date: 2018-11-03 words: 3055 flesch: 47 summary: Thus, we summarized the characteristics and pregnancy outcomes of these patients and explored the probable risk factors and predictive factors for pneumonia during pregnancy and the appropriate timing of delivery in severe pneumonia patients. key: cord-003291-zuqx6ksy authors: Tang, Pingping; Wang, Jiangshan; Song, Yingna title: Characteristics and pregnancy outcomes of patients with severe pneumonia complicating pregnancy: a retrospective study of 12 cases and a literature review date: 2018-11-03 journal: BMC Pregnancy Childbirth DOI: 10.1186/s12884-018-2070-0 sha: doc_id: 3291 cord_uid: zuqx6ksy BACKGROUND: Pneumonia during pregnancy has been proven to be associated with increased maternal and fetal morbidity and mortality. keywords: medical; outcomes; patients; pneumonia; preeclampsia; pregnancy; trimester cache: cord-003291-zuqx6ksy.txt plain text: cord-003291-zuqx6ksy.txt item: #45 of 2876 id: cord-003376-2qi4aibx author: van de Groep, Kirsten title: Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study date: 2018-12-18 words: 3893 flesch: 38 summary: Patients with CMV reactivation had a more pronounced increase of IP-10 (median percentage difference of 44% versus −15%) and decrease of IL-1RA (median percentage difference of −41% versus 0%) on day 7 after viremia onset compared with CMV seropositive patients without reactivation. Based on previous studies in ICU patients, there is a clear pathophysiological link between inflammation and immune suppression on the one hand and the subsequent risk of CMV reactivation on the other keywords: biomarkers; cmv; comparison; cytomegalovirus; icu; patients; reactivation; study; time cache: cord-003376-2qi4aibx.txt plain text: cord-003376-2qi4aibx.txt item: #46 of 2876 id: cord-003404-eqgc8v7y author: May, Win Lai title: Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children date: 2019-01-02 words: 4952 flesch: 52 summary: The clinical parameters of warning signs were more frequent in severe dengue patients, which was in agreement with previous studies; hepatomegaly was a risk factor of DSS or severe dengue infection In cases of severe G6PD deficiency, the lack of oxidative metabolism can cause a reduction in oxygen-dependent phagocytosis as observed in chronic granulomatous disease [4] and allows for viral replication keywords: activity; children; deficiency; dehydrogenase; dengue; g6pd; infection; myanmar; patients; phosphate; study cache: cord-003404-eqgc8v7y.txt plain text: cord-003404-eqgc8v7y.txt item: #47 of 2876 id: cord-003446-yp5d29fk author: Edwards, Michael title: An Uncommon Cause of Spontaneous Pneumomediastinum and Subcutaneous Emphysema date: 2017-02-03 words: 1291 flesch: 39 summary: Computerised tomography is a valuable diagnostic tool for identifying pneumomediastinum in patients with subcutaneous emphysema. A repeat chest x-ray showed extensive subcutaneous emphysema and led to a diagnosis of suspected pneumomediastinum. keywords: emphysema; patient; pneumomediastinum cache: cord-003446-yp5d29fk.txt plain text: cord-003446-yp5d29fk.txt item: #48 of 2876 id: cord-003520-f3jz59pt author: Arabi, Yaseen M. title: Free Fatty Acids’ Level and Nutrition in Critically Ill Patients and Association with Outcomes: A Prospective Sub-Study of PermiT Trial date: 2019-02-13 words: 4292 flesch: 46 summary: The aims of this study were (1) to evaluate the clinical and nutritional correlates of high FFAs level in critically ill patients and the association with outcomes, and (2) study the effect of short-term caloric restriction (permissive underfeeding) on FFAs level during critical illness. Of 70 enrolled patients, 23 (32.8%) patients had high FFAs level (baseline FFAs level >0.45 mmol/L in females and >0.6 mmol/L in males). keywords: baseline; cholesterol; fatty; ffas; free; insulin; level; patients; study cache: cord-003520-f3jz59pt.txt plain text: cord-003520-f3jz59pt.txt item: #49 of 2876 id: cord-003532-lcgeingz author: None title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: 80115 flesch: 48 summary: Blood cultures were sent as per clinical & laboratory diagnosis of sepsis in ICU patients. Conclusions: HR, lactate levels and age before AVP initiation can predict the response to AVP in ICU patients with NE-resistant hypotension. keywords: acute; admission; age; aim; aki; analysis; arrest; arterial; assessment; baseline; blood; cardiac; care; care unit; cases; clinical; complications; conclusions; correlation; critical; data; days; diagnosis; difference; discharge; ecmo; effect; emergency; factors; failure; fig; figure; fluid; group; high; hospital; hospital mortality; hours; icu; icu admission; icu patients; ill; incidence; increase; injury; intensive; intervention; introduction; lactate; length; levels; low; lung; management; map; mean; median; medical; methods; months; mortality; non; organ; outcome; patients; patients introduction; period; post; pressure; rate; ratio; response; results; resuscitation; risk; score; sepsis; sepsis patients; septic; serum; severity; shock patients; sofa; stay; studies; study; surgery; survival; system; table; test; therapy; time; total; trauma; treatment; ultrasound; unit; use; ventilation; years cache: cord-003532-lcgeingz.txt plain text: cord-003532-lcgeingz.txt item: #50 of 2876 id: cord-003533-8m0vyxq8 author: Jayathilaka, P. G. N. S. title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 words: 4150 flesch: 47 summary: key: cord-003533-8m0vyxq8 authors: Jayathilaka, P. G. N. S.; Mendis, A. S. V.; Perera, M. H. M. T. S.; Damsiri, H. M. T.; Gunaratne, A. V. C.; Agampodi, Suneth Buddhika title: An outbreak of leptospirosis with predominant cardiac involvement: a case series date: 2019-03-18 journal: BMC Infect Dis DOI: 10.1186/s12879-019-3905-7 sha: doc_id: 3533 cord_uid: 8m0vyxq8 BACKGROUND: Severe leptospirosis is known to cause multi organ dysfunction including cardiac involvement. We present a case series of severe leptospirosis with cardiac involvement observed during a period of one month at Colombo-North Teaching Hospital, Sri Lanka. keywords: cardiac; case; day; illness; involvement; leptospirosis; myocarditis; patients cache: cord-003533-8m0vyxq8.txt plain text: cord-003533-8m0vyxq8.txt item: #51 of 2876 id: cord-003615-vpzzsdld author: Thompson, Kelly B. title: Late immune consequences of combat trauma: a review of trauma-related immune dysfunction and potential therapies date: 2019-04-24 words: 8892 flesch: 30 summary: Incidence and epidemiology of combat injuries sustained during the surge portion of operation Iraqi freedom by a U.S. Army brigade combat team Combat musculoskeletal wounds in a US Army brigade combat team during operation Iraqi freedom Pelvic, spinal and extremity wounds among combat-specific personnel serving in Iraq and Afghanistan (2003-2011): a new paradigm in military musculoskeletal medicine An analysis of inhospital deaths at a modern combat support hospital Early prevention of trauma-related infection/ sepsis Inflammatory response is associated with critical colonization in combat wounds Blast injuries: mechanics and wounding patterns Negative pressure wound therapy in the management of combat wounds: a critical review Challenges of treating modern military trauma wounds Optimal use of blood in trauma patients The evolution of pain management in the critically ill trauma patient: emerging concepts from the global war on terrorism This tolerant phenotype was first described in trauma patients in the mid-1990s, where monocytes isolated from injured patients had a reduced cytokine response to ex vivo stimulation of endotoxins [27] . keywords: cells; combat; development; dysfunction; immune; infection; inflammatory; injuries; injury; mortality; patients; response; sepsis; syndrome; trauma; wound cache: cord-003615-vpzzsdld.txt plain text: cord-003615-vpzzsdld.txt item: #52 of 2876 id: cord-003686-1pfk4qve author: Kaneko, Naoe title: The role of interleukin-1 in general pathology date: 2019-06-06 words: 9513 flesch: 32 summary: Activated IL-1 is incapable of functioning until recognized by cell surface receptors. Gevokizumab is an anti-IL-1β monoclonal antibody, IgG2, which improved glucose control and β-cell function in a diet-induced-obesity mouse model [163] and in the presence of IL-1β-driven inflammatory diseases [164] . keywords: activation; anakinra; anti; canakinumab; cancer; cells; disease; human; il-1; inflammasome; inflammation; interleukin-1; nlrp3; patients; protein; receptor; response; study; syndrome; treatment; tumor cache: cord-003686-1pfk4qve.txt plain text: cord-003686-1pfk4qve.txt item: #53 of 2876 id: cord-003701-i70ztypg author: Chow, Eric J. title: Influenza virus-related critical illness: prevention, diagnosis, treatment date: 2019-06-12 words: 6873 flesch: 16 summary: • Enterically administered oseltamivir is recommended for influenza patients except for those with contraindications (e.g., gastric stasis, ileus, malabsorption). In particular, a large pooled individual patient-level meta-analysis of observational studies from 38 countries identified a 38% reduction in risk of mortality in critically ill adults and those aged ≥ 16 years old when comparing early NAI treatment (< 48 h) with later treatment (> 48 h), and a 69% reduction in mortality risk between influenza patients receiving early NAI treatment and those who did not receive NAIs [72] . keywords: adults; infection; influenza; mortality; oseltamivir; patients; risk; studies; study; treatment; virus cache: cord-003701-i70ztypg.txt plain text: cord-003701-i70ztypg.txt item: #54 of 2876 id: cord-003798-nki2sasr author: Vidaur, Loreto title: Human metapneumovirus as cause of severe community-acquired pneumonia in adults: insights from a ten-year molecular and epidemiological analysis date: 2019-07-24 words: 3506 flesch: 37 summary: In a large prospective study of ICU patients requiring invasive mechanical ventilation, hMPV was more frequently detected in patients admitted by severe respiratory infection than in patients with other causes, suggesting a causal role of HMPV in the development of severe respiratory infection [24] . Bacterial pneumonia Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: a CHAID decision-tree analysis Effect of procalcitonin guided guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the Pro-HOSP randomized controlled trial Procalcitonin guidance of antibiotic therapy in community acquired pneumonia: a randomized trial Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases The role of human Metapneumovirus genetic diversity and nasopharyngeal load on symptom severity in adults LV made substantial contribution to the conception and design of the work, the acquisition, analysis and interpretation of the data and has drafted the work. keywords: hmpv; human; icu; infection; metapneumovirus; patients; pneumonia; study cache: cord-003798-nki2sasr.txt plain text: cord-003798-nki2sasr.txt item: #55 of 2876 id: cord-003828-bhfghcby author: Zrzavy, Tobias title: Vaccination in Multiple Sclerosis: Friend or Foe? date: 2019-08-07 words: 5607 flesch: 29 summary: Plotkin's Vaccines Vaccine adjuvants: putting innate immunity to work In vivo activation of antigen-specific CD4 T cells Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release Immunological mechanisms of vaccination Vaccine adjuvants: from 1920 to 2015 and beyond Comparative safety of vaccine adjuvants: a summary of current evidence and future needs Adjuvants Safety Project C. Safety of vaccine adjuvants: focus on autoimmunity Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity Cell recruitment and cytokines in skin mice sensitized with the vaccine adjuvants: saponin, incomplete Freund's adjuvant, and monophosphoryl lipid A Human T H 17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation Cellular mechanisms of IL-17-induced blood-brain barrier disruption Induction of lupus autoantibodies by adjuvants Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland Carbohydrate-based immune adjuvants Extrafollicular antibody responses Control systems and decision making for antibody production Rabies vaccine prepared in human cell cultures: progress and perspectives Therefore, vaccination of MS patients is of major interest. keywords: adjuvants; cells; hepatitis; immune; influenza; patients; risk; sclerosis; vaccination; vaccines cache: cord-003828-bhfghcby.txt plain text: cord-003828-bhfghcby.txt item: #56 of 2876 id: cord-003832-q1422ydi author: Koyama, Kansuke title: Biomarker profiles of coagulopathy and alveolar epithelial injury in acute respiratory distress syndrome with idiopathic/immune-related disease or common direct risk factors date: 2019-08-19 words: 4663 flesch: 34 summary: A secondary analysis of the LUNG SAFE study confirmed that 8.3% of ARDS patients had no common risk factors that were identified when ARDS was recognized [6] . Thrombin-antithrombin complex (TAT) levels are increased in ARDS patients, reflecting tissue factor-and contact phase-mediated activation of coagulation cascade and excessive thrombin generation. keywords: acute; ards; biomarkers; factors; injury; lung; patients; pneumonia; respiratory; risk; study cache: cord-003832-q1422ydi.txt plain text: cord-003832-q1422ydi.txt item: #57 of 2876 id: cord-004096-obrq7q57 author: Benghanem, Sarah title: Brainstem dysfunction in critically ill patients date: 2020-01-06 words: 5812 flesch: 31 summary: Opioids might also contribute to brainstem dysfunction, as they depress the ARAS, respiratory centers, and brainstem reflexes (notably pupillary light and cough reflexes). key: cord-004096-obrq7q57 authors: Benghanem, Sarah; Mazeraud, Aurélien; Azabou, Eric; Chhor, Vibol; Shinotsuka, Cassia Righy; Claassen, Jan; Rohaut, Benjamin; Sharshar, Tarek title: Brainstem dysfunction in critically ill patients date: 2020-01-06 journal: Crit Care DOI: 10.1186/s13054-019-2718-9 sha: doc_id: 4096 cord_uid: obrq7q57 The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. keywords: brainstem; consciousness; dysfunction; illness; impairment; inflammatory; lesions; mortality; motor; nerve; nuclei; patients; reflexes; table cache: cord-004096-obrq7q57.txt plain text: cord-004096-obrq7q57.txt item: #58 of 2876 id: cord-004147-9bcq3jnm author: Fernando, Shannon M. title: New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study date: 2020-01-13 words: 4163 flesch: 41 summary: We determined patient costs using the case-costing system of the Ottawa Hospital Data Warehouse, as done previously [17, 23, 27] . Finally, comparisons of patient costs between patients with and without NOAF are shown in Table 5 Table S6 ). keywords: costs; data; hospital; icu; mortality; noaf; patients; sepsis cache: cord-004147-9bcq3jnm.txt plain text: cord-004147-9bcq3jnm.txt item: #59 of 2876 id: cord-004186-m817oudw author: Iwata, Shihoko title: Anesthetic management of a patient with a continuous-flow left ventricular assist device for video-assisted thoracoscopic surgery: a case report date: 2020-01-20 words: 3771 flesch: 41 summary: Management of LVAD patients for noncardiac surgery: a single-institution study Complications, risk factors, and staffing patterns for noncardiac surgery in patients with left ventricular assist devices Noncardiac surgery in long-term implantable left ventricular assistdevice recipients The anesthetic considerations in patients with ventricular assist devices presenting for noncardiac surgery: a review of eight cases Perioperative management of a patient with a nonpulsatile left ventricular-assist device presenting for noncardiac surgery Case 6-2010: noncardiac surgery in patients with a left ventricular assist device Laparoscopic cholecystectomy in a patient with an implantable left ventricular assist device Perioperative management of two patients with left ventricular assist devices presenting for noncardiac surgery in the prone position. Left ventricular assist devices (LVADs) are gaining popularity as a viable treatment, and patients with LVADs survive for many years; consequently, such patients who require noncardiac surgery are becoming increasingly common [1, 2] . keywords: function; heart; lvad; management; mmhg; olv; patient; surgery cache: cord-004186-m817oudw.txt plain text: cord-004186-m817oudw.txt item: #60 of 2876 id: cord-004263-m1ujhhsc author: Koekkoek, W. A. C. title: The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study date: 2020-02-03 words: 3157 flesch: 40 summary: A reliable estimation of the energy expenditure (EE) of ICU patients may help to avoid these phenomena. However, this hypothesis has not been studied in ICU patients with the previously described indications for the use of continuous NMBA infusion. keywords: cisatracurium; infusion; kcal; patients; study cache: cord-004263-m1ujhhsc.txt plain text: cord-004263-m1ujhhsc.txt item: #61 of 2876 id: cord-004310-hl7fa4af author: Matsuishi, Yujiro title: Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients date: 2020-02-10 words: 3490 flesch: 38 summary: Average age of the total population was 26 (± 40) weeks and DS patients had a high probability to be younger than normal patients (12 ± 22 weeks vs. 28 ± 42 weeks, respectively; probability of the DS group mean was greater than normal = 0.93) while muscle relaxant days had a high probability to be longer for DS patients (3 days in DS vs 0 days in controls; probability of the DS group's days were greater than normal = 0.97). RACHS-1 scores were almost identical in the DS patients compared with normal patients (2 in DS vs 2 in controls; probability of the DS group's severity was greater than normal = 0.13) and PELOD-2 found that DS patients had a higher probability to be younger than normal patients (5.6 ± 1.9 in DS vs. 4.1 ± 1.8 in controls; probability of DS group severity was greater than www.nature.com/scientificreports www.nature.com/scientificreports/ normal = 0.99). keywords: patients; probability; sedation; study; surgery; syndrome cache: cord-004310-hl7fa4af.txt plain text: cord-004310-hl7fa4af.txt item: #62 of 2876 id: cord-004314-gtwtakpr author: Holmen, Heidi title: Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies date: 2020-02-10 words: 8171 flesch: 43 summary: Together, these themes describe how clinical encounters with patients depend, to a large degree, on the personal interaction between patient and professional, real clinical practice situations and professional ideals, and contextual support and managing one's own emotions. key: cord-004314-gtwtakpr authors: Holmen, Heidi; Larsen, Marie Hamilton; Sallinen, Merja Helena; Thoresen, Lisbeth; Ahlsen, Birgitte; Andersen, Marit Helen; Borge, Christine Råheim; Eik, Hedda; Wahl, Astrid Klopstad; Mengshoel, Anne Marit title: Working with patients suffering from chronic diseases can be a balancing act for health care professionals - a meta-synthesis of qualitative studies date: 2020-02-10 journal: BMC Health Serv Res DOI: 10.1186/s12913-019-4826-2 sha: doc_id: 4314 cord_uid: gtwtakpr BACKGROUND: keywords: care; diabetes; disease; experiences; hcps; health; nurses; papers; patients; research; studies; study; working cache: cord-004314-gtwtakpr.txt plain text: cord-004314-gtwtakpr.txt item: #63 of 2876 id: cord-004339-7nwpic3d author: Rennie, Katherine J. title: Nasal Airway Obstruction Study (NAIROS): a phase III, open-label, mixed-methods, multicentre randomised controlled trial of septoplasty versus medical management of a septal deviation with nasal obstruction date: 2020-02-13 words: 8417 flesch: 39 summary: Keywords: Nasal septum, Nasal obstruction, Septoplasty, Turbinates, Mometasone furoate, Clinical trial, Cost-effectiveness, Process evaluation Background Septoplasty is surgery to straighten the nasal partition between the two nostrils (the septum). The estimation of a preference-based measure of health from the SF-36 The use of nasal spirometry as an objective measure of nasal septal deviation and the effectiveness of septal surgery Use of peak nasal inspiratory flowmetry and nasal decongestant to evaluate outcome of septoplasty with radiofrequency coblation of the inferior turbinate The accuracy and reproducibility of rhinospirometry in detecting flow asymmetry in a nasal cavity model The value of bilateral simultaneous nasal spirometry in the assessment of patients undergoing septoplasty SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials Nasal septal surgery: evaluation of symptomatic and general health outcomes Patterns of treatment effects in subsets of patients in clinical trials Reporting attrition in randomised controlled trials Practice based, longitudinal, qualitative interview study of computerised evidence based guidelines in primary care The NAtional randomised controlled Trial of Tonsillectomy IN Adults (NATTINA): a clinical and cost-effectiveness study: study protocol for a randomised control trial Distributed decision making: the anatomy of decisions-in-action Clear obstacles and hidden challenges: understanding recruiter perspectives in six pragmatic randomised controlled trials Capturing users' experiences of participating in cancer trials Evaluating complex interventions and health technologies using normalization process theory: development of a simplified approach and web-enabled toolkit A feasibility study incorporating a pilot randomised controlled trial of oral feeding plus pre-treatment gastrostomy tube versus oral feeding plus as-needed nasogastric tube feeding in patients undergoing chemoradiation for head and neck cancer (TUBE trial): study protocol The constant comparative method of qualitative analysis The quality of qualitative research. keywords: analysis; data; health; management; medical; months; nairos; nasal; nose; outcome; participants; patients; recruitment; septoplasty; study; surgery; treatment; trial cache: cord-004339-7nwpic3d.txt plain text: cord-004339-7nwpic3d.txt item: #64 of 2876 id: cord-004342-9uok77wb author: Lin, Chun-Yu title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date: 2020-02-14 words: 3008 flesch: 31 summary: Eur Infective endocarditis: an analysis based on strict case definitions Current features of infective endocarditis in elderly patients: results of the International Collaboration on Endocarditis Prospective Cohort Study Age-dependent profile of left-sided infective endocarditis: a 3-center experience Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young, and the councils on clinical cardiology, stroke, and cardiovascular surgery and anesthesia AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association task force on practice guidelines Valve surgery in active endocarditis patients complicated by intracranial haemorrhage: the influence of the timing of surgery on neurological outcomes Native valve infective endocarditis in elderly and younger patients: comparison of clinical features and outcomes with use of Duke criteria and the Duke endocarditis database Carpentier's Reonstructive Valve Surgery Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury A simulation study of the number of events per variable in logistic regression analysis Sparse data bias: A problem hiding in plain sight A goodness-of-fit test for the multiple logistic regression model The evolution of cardiovascular surgery in elderly patient: a review of current options and outcomes Early and late predictors of mortality following on-pump coronary artery bypass graft surgery in the elderly as compared to a younger population Outcomes in nonagenarians after heart valve replacement operation Infective endocarditis in elderly patients: clinical characteristics and outcome Physiology of cardiovascular aging The changing clinical aspects of infective endocarditis: descriptive review of 90 episodes in a French teaching hospital and risk factors for death Risk of embolism and death in infective endocarditis: prognostic value of echocardiography, a prospective multicenter study Optimal timing of surgery for active infective endocarditis with cerebral complications: a Japanese multicentre study Chronic kidney disease in the elderly: evaluation and management Outcomes of cardiac surgery in chronic kidney disease We thank Tao-Hsin Tung, Department of Medical Research and Education, Cheng-Hsin General Hospital, for statistical assistance. key: cord-004342-9uok77wb authors: Lin, Chun-Yu; Lu, Cheng-Hui; Lee, Hsiu-An; See, Lai-Chu; Wu, Meng-Yu; Han, Yi; Tseng, Chi-Nan; Su, I-Li; Li, Han-Yan; Tsai, Feng-Chun title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: keywords: complications; endocarditis; group; infective; patients; study; surgery cache: cord-004342-9uok77wb.txt plain text: cord-004342-9uok77wb.txt item: #65 of 2876 id: cord-004379-91a7sgir author: Han, Nayoung title: Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews date: 2020-02-20 words: 3261 flesch: 39 summary: Scand Emergency use authorization for intravenous peramivir: evaluation of safety in the treatment of hospitalized patients infected with 2009 H1N1 influenza A virus Can Disproportionality Analysis of Post-marketing Case Reports be Used for Comparison of Drug Safety Profiles? Outpatient influenza antivirals in a distributed data network for influenza surveillance Data Mining Techniques in Pharmacovigilance: Analysis of the Publicly Accessible FDA Adverse Event Reporting System (AERS) Advantages and Limitations of the Federal Adverse Events Reporting System in Assessing Adverse Event Reporting for Eluxadoline Benefits and strengths of the disproportionality analysis for identification of adverse drug reactions in a pharmacovigilance database The medical dictionary for regulatory activities (MedDRA) WebMD Drugs & Medications -Medical information on prescription drugs, vitamins and over-the-counter medicines Beautiful Soup 4 Beautiful Soup Documentation -Beautiful Use of proportional reporting ratios (PRRs) for signal generation from spontaneous adverse drug reaction reports A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions A Bayesian neural network method for adverse drug reaction signal generation Reported AE cases related to NAIs from the FAERS database were used in this study. keywords: aes; analysis; data; disorders; influenza; nais; oseltamivir; patients cache: cord-004379-91a7sgir.txt plain text: cord-004379-91a7sgir.txt item: #66 of 2876 id: cord-004404-s6udpwxq author: Seifi, Najmeh title: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date: 2020-02-24 words: 4643 flesch: 37 summary: key: cord-004404-s6udpwxq authors: Seifi, Najmeh; Safarian, Mohammad; Nematy, Mohsen; Rezvani, Reza; Khadem-Rezaian, Majid; Sedaghat, Alireza title: Effects of synbiotic supplementation on energy and macronutrients homeostasis and muscle wasting of critical care patients: study protocol and a review of previous studies date: 2020-02-24 journal: Trials DOI: 10.1186/s13063-020-4136-3 sha: doc_id: 4404 cord_uid: s6udpwxq BACKGROUND: An extreme and persistent dysbiosis occurs among critically ill patients, regardless of the heterogeneity of disease. Gut microbiota in health and disease Current understanding of the human microbiome The role of the microbiome in human health and disease: an introduction for clinicians The impact of probiotics' administration on glycemic control, body composition, gut microbiome, mitochondria, and other hormonal signals in adolescents with prediabetesa randomized, controlled trial study protocol Gut microbiota: an integral moderator in health and disease Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away Muscle wasting: the gut microbiota as a new therapeutic target? Gut barrier dysfunction and microbial translocation in cancer cachexia: a new therapeutic target Malnutrition in critically ill patients in intensive care units Association between malnutrition and clinical outcomes in the intensive care unit: a systematic review Association between malnutrition and 28-day mortality and intensive care length-ofstay in the critically ill: a prospective cohort study Diagnostic criteria for malnutrition-an ESPEN consensus statement Gut microbiota, nutrient sensing and energy balance Gut microbiota and energy balance: role in obesity Use of standard enteral formula versus enteric formula with prebiotic content in nutrition therapy: a randomized controlled study among neuro-critical care patients Microbial cell preparation in enteral feeding in critically ill patients: a randomized, doubleblind, placebo-controlled clinical trial Effect of a multispecies probiotic on inflammatory markers in critically ill patients: a randomized, double-blind, placebocontrolled trial Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis The immune system bridges the gut microbiota with systemic energy homeostasis: focus on TLRs, mucosal barrier, and SCFAs Muscle loss: the new malnutrition challenge in clinical practice Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model Non digestible oligosaccharides modulate the gut microbiota to control the development of leukemia and associated cachexia in mice Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia Beneficial bacteria inhibit cachexia ESPEN guideline on clinical nutrition in the intensive care unit Effectiveness of continuous enteral nutrition versus intermittent enteral nutrition in intensive care patients: a systematic review Intermittent versus continuous feeding in critically ill adults Treatment of opioid-induced gut dysfunction Bacterial translocation: overview of mechanisms and clinical impact Gastric acid reduction leads to an alteration in lower intestinal microflora Probiotics in the critical care unit: fad, fact, or fiction? keywords: care; critical; energy; gut; homeostasis; icu; microbiota; muscle; nutrition; patients; protein; study; wasting cache: cord-004404-s6udpwxq.txt plain text: cord-004404-s6udpwxq.txt item: #67 of 2876 id: cord-004450-daxz9yhp author: Haeberle, Helene title: Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study date: 2020-03-04 words: 5858 flesch: 36 summary: X a X a X a X a X a X a X a Fluid balance X a X a X a X a X a X a X a Transfusion of red blood cells X X X X X X X b X X X Transfusion of thrombocytes X X X X X X X b X X X Anticoagulation Infection X X X X X X X b X X X Anti-infective therapy X X X X X X X b X X X When possible, however, the patient or his legal representative is to be informed both in writing and verbally by the investigator before any study-specific procedure is Iloprost or NaCl 0.9% (control) X X X X X Clinical assessment including outcome X X X X X X X X X Laboratory testing X X X X X X X X Adverse/serious adverse event monitoring X X X X X X X Plasma biomarkers X X X X X X Barthel Index X X X X SOFA score keywords: acute; ards; day; effect; iloprost; injury; lung; patients; pulmonary; study; treatment; trial; ventilation cache: cord-004450-daxz9yhp.txt plain text: cord-004450-daxz9yhp.txt item: #68 of 2876 id: cord-004464-nml9kqiu author: Lhommet, Claire title: Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? date: 2020-03-06 words: 4451 flesch: 40 summary: key: cord-004464-nml9kqiu authors: Lhommet, Claire; Garot, Denis; Grammatico-Guillon, Leslie; Jourdannaud, Cassandra; Asfar, Pierre; Faisy, Christophe; Muller, Grégoire; Barker, Kimberly A.; Mercier, Emmanuelle; Robert, Sylvie; Lanotte, Philippe; Goudeau, Alain; Blasco, Helene; Guillon, Antoine title: Predicting the microbial cause of community-acquired pneumonia: can physicians or a data-driven method differentiate viral from bacterial pneumonia at patient presentation? date: 2020-03-06 journal: BMC Pulm Med DOI: 10.1186/s12890-020-1089-y sha: doc_id: 4464 cord_uid: nml9kqiu BACKGROUND: Community-acquired pneumonia (CAP) requires urgent and specific antimicrobial therapy. We included 153 patients with CAP (70.6% men; 62 [51–73] years old; mean SAPSII, 37 [27–47]), 37% had viral pneumonia, 24% had bacterial pneumonia, 20% had a co-infection and 19% had no identified respiratory pathogen. keywords: bacterial; data; dataset; information; patient; pneumonia; respiratory; viral cache: cord-004464-nml9kqiu.txt plain text: cord-004464-nml9kqiu.txt item: #69 of 2876 id: cord-004515-x22q1f21 author: Pottecher, Julien title: Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients date: 2020-03-18 words: 6820 flesch: 38 summary: The primary trial objective is to demonstrate a reduction in the incidence of moderate-to-severe hypoxaemia in severe trauma patients during the first 7 days from 45% to 30% by providing aerosolized dornase alfa as compared to placebo. This treatment may facilitate ventilator weaning, reduce the burden of trauma-induced lung inflammation and facilitate recovery and rehabilitation in severe trauma patients. keywords: alfa; analysis; blood; data; day; days; dna; dornase; hypoxaemia; incidence; injury; lung; patients; study; trauma; trial; variables cache: cord-004515-x22q1f21.txt plain text: cord-004515-x22q1f21.txt item: #70 of 2876 id: cord-004532-flo9139j author: Andrews, Peter title: Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis date: 2004-12-18 words: 9265 flesch: 40 summary: Last, intrahospital transport poses an important risk to ICU patients. Periextubation pain has received little attention in ICU patients. keywords: acute; authors; care; colonization; failure; icu; infection; intensive; lung; mortality; patients; study; vap; weaning cache: cord-004532-flo9139j.txt plain text: cord-004532-flo9139j.txt item: #71 of 2876 id: cord-004636-t6qldq3s author: Saugel, Bernd title: Journal of Clinical Monitoring and Computing end of year summary 2019: hemodynamic monitoring and management date: 2020-03-14 words: 10310 flesch: 38 summary: An observational cohort study in cardiac surgery patients was performed by Henriques et al. The authors obtained arterial blood pressure measurements from aortic, femoral, and radial artery catheters. keywords: analysis; arterial; authors; blood; cardiac; data; et al; fluid; group; learning; monitoring; patients; pressure; pulse; study; surgery; time cache: cord-004636-t6qldq3s.txt plain text: cord-004636-t6qldq3s.txt item: #72 of 2876 id: cord-004643-uu4uipfy author: Hasan, Mohammad Rubayet title: Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report date: 2020-03-20 words: 3022 flesch: 32 summary: The case highlights both the risk of acquiring MDR superbugs and the severity of these infections in HLH patients. While these factors likely put HLH patients at high risk of infection with MDROs, no such reports has been published to date and the clinical course of such infections in these patients remains unknown. keywords: blood; cmv; hlh; infection; mdros; patient; resistance; treatment; wgs cache: cord-004643-uu4uipfy.txt plain text: cord-004643-uu4uipfy.txt item: #73 of 2876 id: cord-004646-zhessjqh author: Bawazeer, Mohammed title: Adjunct low-dose ketamine infusion vs standard of care in mechanically ventilated critically ill patients at a Tertiary Saudi Hospital (ATTAINMENT Trial): study protocol for a randomized, prospective, pilot, feasibility trial date: 2020-03-20 words: 7844 flesch: 38 summary: A concern was raised about the under-dosing of ketamine compared to ICU ketamine studies. This trial is a prospective, randomized, active controlled, open-label, pilot, feasibility study of adult ICU patients (> 14 years old) on MV. keywords: analysis; care; data; delirium; dose; icu; infusion; ketamine; patients; protocol; randomization; sedation; study; trial cache: cord-004646-zhessjqh.txt plain text: cord-004646-zhessjqh.txt item: #74 of 2876 id: cord-004675-n8mlxe7p author: None title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2019-02-26 words: 86609 flesch: 43 summary: Background: Patients with primary immune deficiencies characterized by severe T lymphopenia and/or poor T cell function and patients posthematopoietic cell transplantation are at high risk of severe viral infections. In this study, we investigated effect of IL12R1 mutation in IL-12/IFNaxis by evaluation of patients whole blood cell response to IL-12 and IFN-, IL-12R1 expression in PBMCs and T cell blasts. keywords: age; age patients; analysis; anti; antibody; assay; autoimmune; autoimmunity; b cells; background; biopsy; blood; bone; case; cd3; cd4; cgd; chronic; cohort; conclusions; cvid patients; data; defects; development; diagnosis; disease; disorders; dose; ebv; elevated; evaluation; expression; failure; family; female; fever; flow; function; gene; group; heterozygous; history; hsct; human; hypogammaglobulinemia; iga; igg; igm; immune; immunodeficiency; immunoglobulin; infants; infections; inflammatory; introduction; laboratory; levels; life; liver; loss; low; lung; lymphocyte; lymphopenia; male; marrow; medical; methods; months; mutations; negative; nk cells; non; normal; novel; number; patients; phenotype; pid; post; presentation; proliferation; protein; range; recurrent; report; respiratory; response; results; risk; scid; sequencing; severe; specific; stem; studies; study; symptoms; syndrome; t cells; testing; therapy; time; transplant; transplantation; treatment; variant; weeks; years cache: cord-004675-n8mlxe7p.txt plain text: cord-004675-n8mlxe7p.txt item: #75 of 2876 id: cord-004894-75w35fkd author: None title: Abstract date: 2006-06-14 words: 92227 flesch: 48 summary: A marked interindividual variability in high risk patients is seen, but at present the basis for this variability is unclear and can not be explained solely by environmental factors. Conclusion and discussion: This study provides evidence for a role for genetic variation of MCP-1 gene in the occurrence of coronary collaterals in high risk patients. keywords: abstract; age; analysis; association; background; baseline; birth; blood; bmi; breast; breast cancer; cancer patients; cancer risk; cardiovascular; care; cases; characteristics; chd; children; clinical; cohort; cohort study; conclusion; control; coronary; countries; data; death; design; diabetes; differences; discussion; disease; dutch; effect; epidemiological; european; evidence; exposure; follow; general; group; health; incidence; increase; index; information; intake; levels; life; mean; methods; model; months; mortality; netherlands; non; number; objectives; outcome; participants; patients; period; population; practice; pressure; prevalence; primary; public; quality; questionnaire; rates; ratio; regression; research; results; risk; risk factors; risk patients; screening; self; smoking; specific; status; studies; study; subjects; survival; time; total; treatment; use; weight; women; years cache: cord-004894-75w35fkd.txt plain text: cord-004894-75w35fkd.txt item: #76 of 2876 id: cord-004949-icsey27p author: Fernandez-Botran, Rafael title: Contrasting Inflammatory Responses in Severe and Non-severe Community-acquired Pneumonia date: 2014-02-21 words: 4052 flesch: 39 summary: Compared to non-severe CAP patients, the severe CAP group showed higher plasma levels of pro- and anti-inflammatory cytokines but in contrast, lower sputum concentrations of pro-inflammatory cytokines. However, neutrophils from severe CAP patients showed reduced respiratory burst activity compared to the non-severe group. keywords: cap; cytokines; group; neutrophil; patients; pneumonia; response; samples; sputum; study cache: cord-004949-icsey27p.txt plain text: cord-004949-icsey27p.txt item: #77 of 2876 id: cord-004986-en7taikk author: Nagy, Nathalie title: Infections gastro-intestinales chez le patient immunocompromis date: 2002 words: 6150 flesch: 50 summary: Certaines 6tudes rapportent des strongyloidoses diss6min6es chez des patients immunocompromis. Bien avant les 6pid6mies de sida, le toxoplasme 6tait reconnu comme protozoaire responsable d'infections opportunistes chez les patients immunocompromis. keywords: aids; aux; cd4; chez; cmv; dans; des; est; hiv; immunocompromis; infections; les; niveau; par; patients; que; sida; sont; tract; une cache: cord-004986-en7taikk.txt plain text: cord-004986-en7taikk.txt item: #78 of 2876 id: cord-005105-twsy61oq author: None title: SIU 2015 Abstracts date: 2015-09-21 words: 124278 flesch: 51 summary: Th e patients were discharged from hospital aft er a median of 4.5 days (range 3 to 7). Th e patients were classifi ed into Group 1 (n=67, 60.3%) and into Group 2 (n=44, 39.7%) based on the presence of BPH. keywords: aft; age; analysis; approach; average; biopsy; bladder; bladder cancer; blood; cancer; cancer patients; carcinoma; cases; catheter; cells; clinical; complications; conclusion; control; data; day; days; defi; diagnosis; diff; disease; dysfunction; e aim; e bladder; e diff; e fi; e incidence; e mean; e median; e patient; e results; e study; e use; ects; eff; effi; ere; erectile; erence; experience; expression; factors; female; follow; function; grade; group; group patients; hospital; identifi; improvement; index; initial; injury; introduction; kidney; laparoscopic; left; level; male; management; medical; months; nephrectomy; non; number; objective; operative; outcomes; overall; pain; patients; pca; pelvic; period; positive; post; postoperative; preoperative; primary; procedure; prostate; prostate cancer; prostatectomy; prostatic; psa; radical; range; rate; recurrence; renal; results; risk; rst; score; signifi; single; size; specifi; stage; standard; stent; stone; stricture; studies; study; surgery; surgical; survival; symptoms; technique; term; th e; therapy; time; total; tract; treated; treatment; tumor; urethral; urinary; urine; voiding; volume; weeks; years cache: cord-005105-twsy61oq.txt plain text: cord-005105-twsy61oq.txt item: #79 of 2876 id: cord-005147-mvoq9vln author: None title: Autorenregister date: 2017-02-23 words: 86765 flesch: 41 summary: While a long list of gene mutations have so far been described to be responsible for the disease phenotype, little is known about the underlying neuronal mechanisms. WD pathogenesis, however, can not only be explained by gene coding mutations since phenotypes exhibit strong variations despite the same exonic DNA makeup in the gene. keywords: activity; addition; age; allele; analysis; approach; array; association; autosomal; blood; brain; breast; cancer; candidate; carriers; cases; cause; cell; children; chromosome; clones; coding; cohort; complex; conclusion; controls; data; delay; deletion; development; diagnosis; different; disability; disease; disease genes; disorders; dna; dominant; effect; exome; exome sequencing; exon; expression; factors; families; family; features; female; findings; function; gene; gene expression; generation; genetic; genome; genomic; germany; germline; growth; heterozygous; homozygous; human; identification; individuals; institute; levels; loci; loss; low; methods; methylation; mice; missense; model; molecular; mouse; mrna; mutations; negative; new; ngs; non; normal; novel; novo; number; onset; p =; panel; parents; pathways; patients; pcr; phenotype; potential; present; protein; receptor; recessive; regions; report; results; risk; rna; role; samples; sequence; sequencing; sites; skin; specific; spectrum; splice; splicing; studies; study; syndrome; system; target; testing; time; tissue; transcription; treatment; tumor; variants; wes; years cache: cord-005147-mvoq9vln.txt plain text: cord-005147-mvoq9vln.txt item: #80 of 2876 id: cord-005420-60ie0pfd author: Sparrelid, E title: Bacteraemia during the aplastic phase after allogeneic bone marrow transplantation is associated with early death from invasive fungal infection date: 1998-10-09 words: 3836 flesch: 40 summary: However, in patients with bacteraemia, 21 of 44 deaths were attributable to invasive fungal infections (18 candida, three aspergillus; autopsy findings). Among patients with negative blood cultures during the aplastic phase, 6/25 died of invasive fungal infection (three candida, one saccaromyces and two aspergillus). keywords: bacteraemia; bmt; bone; death; fungal; infections; marrow; patients cache: cord-005420-60ie0pfd.txt plain text: cord-005420-60ie0pfd.txt item: #81 of 2876 id: cord-005425-0hxow3sj author: Lekakis, L title: Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies date: 2006-08-07 words: 2769 flesch: 51 summary: The current status of hematopoietic cell transplantation Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors Transplants of umbilical cord blood or bone marrow from unrelated donors in adults with Acute Leukemia Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia Induction of a transient graft vs leukemia effect following unrelated cord blood transplantation Differential cytotoxicity of cord blood and bone marrowderived natural killer cells consensus conference on acute GVHD grading Bayesian sequential monitoring designs for single-arm clinical trials with multiple outcomes Hematopoietic engraftment and survival in adults recipients of umbilical-cord blood from unrelated donors Outcomes among 562 recipients of placental-blood transplants from unrelated donors Umbilical cord blood transplantation in adults: results of the prospective Cord Blood Transplantation (COBLT) Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies Tacrolimus for prevention of graftversus-host disease after mismatched unrelated donor cord blood transplantation Successful engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with advanced hematological diseases Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced intensity conditioning Effect of antithymocyte globulin on quantitative immune recovery and graft-versus-host disease after partially T-cell-depleted bone marrow transplantation: a comparison between recipients of matched related and matched unrelated donor grafts Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells Transplantation of ex key: cord-005425-0hxow3sj authors: Lekakis, L; Giralt, S; Couriel, D; Shpall, E J; Hosing, C; Khouri, I F; Anderlini, P; Korbling, M; Martin, T; Champlin, R E; de Lima, M title: Phase II study of unrelated cord blood transplantation for adults with high-risk hematologic malignancies date: 2006-08-07 journal: keywords: blood; cord; days; engraftment; gvhd; patients; transplantation cache: cord-005425-0hxow3sj.txt plain text: cord-005425-0hxow3sj.txt item: #82 of 2876 id: cord-005452-ouookpd8 author: Ghosh, K title: Successful non-invasive ventilatory support in a patient with regimen-related toxicity during allogeneic bone marrow transplantation date: 1999-04-19 words: 1158 flesch: 45 summary: It has also been suggested that this modality of management should be severely restricted 3 in allogeneic BMT patients, particularly during their first +100 days. Although a randomised trial 4 has shown no difference in outcome between invasive and non-invasive ventilation, it would be premature to conclude the same for allogeneic BMT patients, particularly when patients are transferred to an ICU in an anatomically different location of the hospital, thereby breaking isolation. keywords: min; patients; support cache: cord-005452-ouookpd8.txt plain text: cord-005452-ouookpd8.txt item: #83 of 2876 id: cord-005453-4057qib7 author: None title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 words: 276280 flesch: 51 summary: Goals: In the present study, we describe the frequencies of CRE colonization and analyzed its relationship with development of CRE bacteremia and mortality in two different scenarios: stem cell transplant patients (HSCT) and Leukemia patients. The aim of this study was to analyse a single centre experience with HSCT patients requiring ICU admission and the factors affecting outcome. keywords: /kg; acute gvhd; administration; adult patients; age; agvhd; aim; allogeneic hsct; allosct; aml; analysis; anti; asct; associated; atg; autologous; b cells; based; blood; blood cells; blood stem; bone; busulfan; car; cases; cause; cd19; cd34; cd4; cell count; cell depletion; cell disease; cell dose; cell graft; cell lymphoma; cell source; cell therapy; cell transplantation; cells; center; chemotherapy; children; chimerism; chronic gvhd; clinical; cmv; cmv disease; cohort; combination; common; complications; conclusions; conditioning; conditioning regimen; control; count; criteria; csa; csf; cyclophosphamide; data; days; days post; death; declare; development; diagnosis; difference; disclosure; disease; disease patients; disease relapse; dli; donor; donor age; donor chimerism; donor t; donor transplant; dose; early; ebv; ecp; effect; efficacy; engraftment; experience; expression; factors; failure; female; figure; flow; fludarabine; follow; following; free; function; grade; graft; group; group patients; gvhd grade; gvhd patients; gvhd prophylaxis; haploidentical; haploidentical hsct; hct; hematopoietic; high; hla; hospital; host disease; hsct group; hsct patients; hsct recipients; iii; immune; impact; incidence; increase; induction; infection; infusion; intensity; leukemia patients; levels; lymphocyte; lymphoma patients; major; male; marrow; marrow transplantation; matched; mds; mean; median; median os; medical; methods; mm patients; mobilization; months; mortality; mrd; msd; mud; multiple; myeloid; myeloma patients; n=1; negative; neutrophil; nhl patients; nk cells; non; nrm; number; option; outcome; overall; patients; patients age; patients background; patients characteristics; pbsc; pcr; pediatric; period; pfs; pgf patients; phase; platelet; population; positive; post; post transplant; potential; pre; present; previous; primary; prior; procedure; progression; protocol; ptcy; pts; range; rate; ratio; reactivation; received; reconstitution; recovery; reduced; refractory; regimen; relapse; remission; response; results; retrospectively; risk patients; safety; samples; sc patients; second; secondary; serum; severe; sibling; specific; standard; status; stem cell; steroid; studies; study; study patients; survival; syndrome; system; t cells; table; term; test; therapy; time; total; toxicity; transplant patients; transplantation background; transplanted; treatment; tumor; type; underwent; unrelated; use; versus; vod; years cache: cord-005453-4057qib7.txt plain text: cord-005453-4057qib7.txt item: #84 of 2876 id: cord-005460-ezrn8cva author: None title: Physicians – Poster Session date: 2017-07-28 words: 287532 flesch: 53 summary: After three months of treatment patient showed an increase in T cells count (CD3, 411/mmc), and a decrease of toxic metabolites: AXP, 1.652 micromol/ml RBC; dAXP, 0.011 micromol/ml RBC; %dAXP, 0.7 maternal T-cell engraftment persists, despite a good response to the PEG-ADA therapy. Moreover, caspases pathway was significantly activated in thawing CD3+, CD56+ and CD14 + cells: FLICA+ cells % in thawing cells were, respectively, 16.8%, 31.1% and 6.2% vs 3%, 9.7% and o1% in fresh cells. keywords: acute gvhd; adult patients; age; aim; allogeneic; allogeneic hsct; aml patients; analysis; anti; asct; associated; atg; autologous; based; beam; blood; blood cell; blood stem; bone; busulfan; cases; cause; cd34; cell count; cell disease; cell dose; cell lymphoma; cell source; cell therapy; cell transplantation; cells; center; chemotherapy; children; chimerism; chronic gvhd; clinical; cmv; cohort; collection; complete; complications; conditioning; conditioning regimen; conflict; consecutive; control; cord; count; cr patients; criteria; csf; cyclophosphamide; data; days; death; development; diagnosis; difference; disclosure; disease; disease relapse; disease risk; dli; donor; donor cell; donor hsct; dose; early; ebv; ecp; effect; efficacy; engraftment; experience; factors; failure; female; figure; fludarabine; follow; following; free; function; grade; graft; group; group patients; gvhd; gvhd grade; gvhd patients; gvhd prophylaxis; haploidentical; hct; hematology; hematopoietic; high; hla; hospital; host disease; hr =; hsct patients; hsct recipients; iii; immune; impact; incidence; increase; induction; infection; infusion; intensity; interest; leukemia patients; levels; line; lymphoma patients; major; male; malignancies; marrow; marrow transplantation; matched; mds patients; mean; median; median follow; median os; melphalan; mobilization; months; mortality; mrd; mud; myeloablative; myeloid; myeloma patients; n =; negative; neutrophil; nk cell; non; nrm; number; outcome; overall; p =; patients; patients characteristics; patients relapse; pbsc; pediatric; period; pfs; platelet; population; positive; post; post hsct; post transplant; potential; pre; primary; prior; procedure; progression; pts; range; rate; reactivation; receiving; recipients; recovery; refractory; regimen; relapse; related; remission; report; respectively; response; results; ric; risk group; risk patients; score; second; secondary; setting; severe; sibling; significant; specific; standard; status; stem cell; steroid; studies; study; survival; syndrome; t cell; table; tbi; term; therapy; time; tma patients; total; toxicity; transplant patients; transplanted; treatment; trm; type; underwent; university; unrelated; use; versus; vod; years cache: cord-005460-ezrn8cva.txt plain text: cord-005460-ezrn8cva.txt item: #85 of 2876 id: cord-005478-5iu38pr6 author: None title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Oral Session date: 2019-07-03 words: 63536 flesch: 53 summary: Commonly reported AEs (≥20% patients) were URTI, AST/ALT elevations, fatigue, nausea and diarrhea. %]) attributed to injection site-related TEAEs. keywords: acute; age; allogeneic; aml; analysis; atg; background; blood; car; cases; cell; cell transplantation; chronic; cmv; cohort; conclusions; conditioning; data; days; disclosure; disease; donor; dose; figure; follow; free; grade; graft; group; gvhd; haplo; hct; hla; hsct; immune; incidence; leukemia; median; methods; months; mortality; mrd; non; nrm; outcome; patients; post; primary; pts; range; rate; regimen; relapse; response; results; ric; risk; score; severe; stem; stem cell; study; survival; t cell; therapy; time; transplant; transplantation; treatment; trial; years cache: cord-005478-5iu38pr6.txt plain text: cord-005478-5iu38pr6.txt item: #86 of 2876 id: cord-005480-yg7salqt author: None title: Oral Sessions and Working Party date: 2008-03-26 words: 72763 flesch: 51 summary: Therefore, we compared BM versus PB in patients patients transplanted after 1994: 1226 patients received BM and 4605 PB. Since transplantation patients were treated only with symptomatic therapy. keywords: acute; age; allogeneic; aml; aml patients; analysis; asct; associated; autologous; blood; bone; cases; cell; cell transplantation; chemotherapy; children; chronic; cmv; conclusion; conditioning; cord; data; days; diagnosis; disease; donor; dose; ebmt; effect; engraftment; factors; failure; follow; grade; graft; group; gvhd; hct; high; hla; host; hsct; iii; impact; incidence; intensity; leukemia; marrow; median; months; mortality; msc; non; number; outcome; patients; phase; positive; post; pre; pts; range; recipients; regimen; relapse; remission; response; results; ric; risk; risk patients; source; stem cell; studies; study; survival; t cells; tbi; term; therapy; time; total; transplantation; transplanted; treatment; trm; unrelated; use; versus; vs.; years cache: cord-005480-yg7salqt.txt plain text: cord-005480-yg7salqt.txt item: #87 of 2876 id: cord-005481-00rezmqj author: Reid, T title: Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial date: 2001-11-22 words: 6685 flesch: 40 summary: However, most cancers that fail surgery and/or radiation are multifocal; clinically beneficial intralesional therapy is therefore not feasible in the majority of cancer patients. EORTC-NCI-AACR Meeting on Molecular Therapeutics of Cancer Intravenous administration of ONYX-015, a selectively-replicating adenovirus, induces antitumoral efficacy Hepatic arterial infusion of chemotherapy following resection of hepatic metastases from colorectal cancer Cancer: Principles and Practice of Oncology Urea cycle disorders: diagnosis, pathophysiology and therapy Identification of a conserved reseptor-binding site on the fiber proteins of CAR-recognizing adenoviridae Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung (see comments) Sero-switch adenovirus-mediated in vivo gene transfer: circumvention of anti-adenovirus humoral immune defenses against repeat adenovirus vector administration by changing the adenovirus serotype An adenovirus E1A mutant that demonstrates potent and selective antitumoral efficacy Replication-selective adenovirus plus cisplatin chemotherapy efficacy is dependent on sequencing but independent of p53 status Intravenous infusion of a replication-selective adenovirus (Onyx-015) in cancer patients: safety feasibility and biological activity Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection We would like to thank the following individuals for their assistance: Margaret Uprichard, Sherry Toney, Amy Waterhouse, Patrick Trown, Deborah Hahn, Ellen Morgan, Phil Custodio. keywords: adenovirus; combination; dose; hepatic; onyx-015; patients; replication; therapy; treatment; tumor cache: cord-005481-00rezmqj.txt plain text: cord-005481-00rezmqj.txt item: #88 of 2876 id: cord-005482-v5iayczy author: None title: Publication Only date: 2016-03-21 words: 27422 flesch: 50 summary: Material (or patients) and methods: Patients with haematological malignancies underwent transplantation in remission of the malignancy. Patients with aGVHD received 2-3 consecutive days of ECP at weekly intervals until response and then tapered to every 2 to 4 weeks, patients with cGVHD received 2 consecutive sessions at 2 week intervals. keywords: acute; allogeneic; asct; autologous; blood; cell; cell transplantation; chemotherapy; conclusion; conditioning; days; disclosure; disease; donor; grade; graft; group; gvhd; hsct; interest; introduction; material; median; methods; months; mortality; myeloma; patients; pts; range; regimen; relapse; results; stem; stem cell; study; survival; therapy; time; transplantation; treatment; years cache: cord-005482-v5iayczy.txt plain text: cord-005482-v5iayczy.txt item: #89 of 2876 id: cord-005487-vac061r8 author: None title: Physicians Abstracts: EBMT 2010 date: 2010-04-07 words: 59087 flesch: 53 summary: Introduction: Development of leukemia or myelodysplasia derived from donor cells termed donor cell leukemia (DCL) is a rare but severe complication following allogeneic hematopoietic transplantation. Conclusion: The answers to these questions will help to further characterize donor cell derived leukemia and provide new insights into leukemogenesis in general. keywords: acute; age; allogeneic; aml; analysis; asct; autologous; blood; cases; cell transplantation; cells; children; chronic; cmv; conclusion; conditioning; data; days; disease; donor; donor t; dose; ebmt; factors; follow; grade; graft; group; gvhd; hct; high; hla; hsct; incidence; infl; leukemia; median; methods; months; mortality; n =; non; number; outcome; p =; patients; pts; range; regimen; relapse; response; results; ric; risk; rst; severe; signifi; specifi; stem; stem cell; study; survival; t cells; therapy; time; transplantation; treatment; unrelated; vs.; years cache: cord-005487-vac061r8.txt plain text: cord-005487-vac061r8.txt item: #90 of 2876 id: cord-005496-cnwg4dnn author: Gutierrez, Guillermo title: Artificial Intelligence in the Intensive Care Unit date: 2020-03-24 words: 5014 flesch: 38 summary: For those wishing to delve deeper into the development of machine learning models, a good source of information is the book by Müller and Guido Machine learning models have also been proposed to predict mortality in trauma [25] and pediatric ICU patients keywords: algorithm; care; data; icu; information; learning; machine; model; patients; variables cache: cord-005496-cnwg4dnn.txt plain text: cord-005496-cnwg4dnn.txt item: #91 of 2876 id: cord-005497-w81ysjf9 author: None title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103795 flesch: 50 summary: Conclusions: This is one of the first studies to demonstrate that abnormal RV function is associated with an increased mortality in ICU patients with pneumonia. The fast efficacy of targeted therapies led some intensivists to use them as rescue therapy for ICU patients. keywords: acute; administration; admission; adult patients; age; aim; aki; aki patients; analysis; approach; arrest; arterial; associated; association; average; baseline; blood; cardiac; care; care patients; care unit; cases; clinical; cohort; cohort study; complications; control; critical; critical care; data; day mortality; days; death; delirium; difference; discharge; disease; early; ecmo; effect; emergency; factors; failure; figure; fluid; function; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; ill; incidence; increase; index; infection; injury; intensive; introduction; length; levels; low; lps; lung; management; mean; median; medical; methods; min; model; months; mortality; non; number; observational; organ; outcome; pain; parameters; patients; period; plasma; population; positive; post; pressure; rate; renal; results; risk; score; sepsis; sepsis patients; septic; serum; shock; shock patients; sofa; stay; studies; study; support; surgery; survival; table; test; therapy; time; total; treatment; unit; university; use; value; ventilation; volume; years cache: cord-005497-w81ysjf9.txt plain text: cord-005497-w81ysjf9.txt item: #92 of 2876 id: cord-005503-hm8tvkt3 author: Rasulo, Frank A. title: Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient date: 2020-03-24 words: 5991 flesch: 31 summary: Pupil examination: validity and clinical utility of an automated pupillometer Reliability of standard pupillometry practice in neurocritical care: An observational, double-blinded study Pupillometric analysis of the 'absent light reflex Neurological prognostication of outcome in patients in coma after cardiac arrest Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: a case series Quantitative pupillometry and neuronspecific enolase independently predict return of spontaneous circulation following cardiogenic out-of-hospital cardiac arrest: a prospective pilot study Quantitative versus standard pupillary light reflex for early prognostication in comatose cardiac arrest patients: an international prospective multicentre double-blinded study Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study Infrared pupillometry during uncal herniation Prognosis and clinical relevance of anisocoria-craniotomy latency for epidural hematoma in comatose patients Use of admission Glasgow Coma Score, pupil size, and pupil reactivity to determine outcome for trauma patients Effects of osmotic therapy on pupil reactivity: quantification using pupillometry in critically ill neurologic patients Optical pupillometry in traumatic brain injury: neurological pupil index and its relationship with intracranial pressure through significant event analysis Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury Automated pupillometry to detect command following in neurological patients: a proof-of-concept study Pupillary reflex measurement predicts insufficient analgesia before endotracheal suctioning in critically ill patients Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables Pupillary dilation reflex and pupillary pain index evaluation during general anaesthesia: a pilot study Pupillometry-guided intraoperative remifentanil administration versus standard practice influences opioid use: a randomized study Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries Transcranial color-coded duplex sonography fir bedside monitoring of central nervous system infection as a consequence of decompressive craniectomy after traumatic brain injury Non-invasive intracranial pressure assessment in brain injured patients using ultrasound-based methods Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study Transcranial Doppler Pulsatility in vasodilation and stenosis Consensus summary statement of the international multidisciplinary consensus conference on multimodality monitoring in neurocritical care Cerebral vasospasm after subarachnoid hemorrhage investigated by means of transcranial Doppler ultrasound Basilar vasospasm diagnosis: investigation of a modified Lindegaard Index based on imaging studies and blood velocity measurements of the basilar artery Transcranial color-coded duplex sonography for evaluation of midline-shift after chronic-subdural hematoma evacuation (TEMASE): A prospective study Accuracy of Power mode transcranial Doppler in the diagnosis of brain death Standardized care versus precision medicine in the perioperative setting: Can point-of-care testing help bridge the gap? A primer for EEG signal processing in anesthesia Electroencephalography and brain oxygenation monitoring in the perioperative period Beyond its use for sedative titration purposes, processed EEG may have some additional applications in ICU patients, including identification of subclinical/ unrecognized seizures or seizures occurring when neuromuscular blocking agents are administered. keywords: brain; eeg; fig; flow; icp; icu; light; monitoring; patients; pupillary; pupillometry; reflex; sedation; transcranial cache: cord-005503-hm8tvkt3.txt plain text: cord-005503-hm8tvkt3.txt item: #93 of 2876 id: cord-005569-9d51l6bn author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: I. Brain injury and neurology, renal failure and endocrinology, metabolism and nutrition, sepsis, infections and pneumonia date: 2008-12-09 words: 10277 flesch: 36 summary: Entropy of the frontal EEG does not discriminate sedation state adequately for clinical use in ICU patients. The cumulated energy deficit in ICU patients primarily on enteral nutrition, which has been reported in several studies, is mainly related to underfeeding during the initial week of ICU stay. keywords: acute; authors; care; control; delirium; glucose; icp; icu; infection; intensive; levels; monitoring; mortality; non; outcome; patients; sepsis; shock; study; therapy cache: cord-005569-9d51l6bn.txt plain text: cord-005569-9d51l6bn.txt item: #94 of 2876 id: cord-005587-8iwsvku9 author: Lindén, Viveka title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date: 2000-10-14 words: 4998 flesch: 48 summary: Indications for ECMO Patients were accepted for ECMO if there was an acute, reversible, life-threatening form of respiratory failure unresponsive to conventional therapy key: cord-005587-8iwsvku9 authors: Lindén, Viveka; Palmér, Kenneth; Reinhard, Jarl; Westman, Reino; Ehrén, Henrik; Granholm, Tina; Frenckner, Björn title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date: 2000-10-14 journal: Intensive Care Med DOI: 10.1007/s001340000697 sha: doc_id: 5587 cord_uid: 8iwsvku9 Objectives: To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO), minimal sedation, and pressure supported ventilation. keywords: bypass; ecmo; extracorporeal; patients; pressure; treatment; ventilation cache: cord-005587-8iwsvku9.txt plain text: cord-005587-8iwsvku9.txt item: #95 of 2876 id: cord-005606-c8c2rfzi author: Gordon, Sharon M. title: Clinical identification of cognitive impairment in ICU survivors: insights for intensivists date: 2004-10-02 words: 4675 flesch: 27 summary: Cognitive impairment is generally associated with inability to return to work, decreased quality of life and independence, and generalized functional decline; an important caveat to this observation, however, is that many investigations on the consequences of cognitive impairment have been carried out in populations with Alzheimer's disease, and may not be directly applicable to ICU survivors [20, 21, 22, 23] . The relationship between cognitive performance and employment and health status in long-term survivors of the acute respiratory distress syndrome: results of an exploratory study The epidemiology of dementia: Alzheimer's disease and vascular dementia Behavioral neurology Neuropsychological sequelae following acute respiratory distress syndrome: two year outcome Predictors of cognitive decline following coronary artery bypass graft surgery Postoperative hypoxia is a contributory factor to cognitive impairment after cardiac surgery The association between delirium and cognitive decline: a review of the empirical literature Cognitive impairment, dementia and quality of life in patients and caregivers A follow-up study of change in quality of life among persons with dementia residing in a long-term care facility The influence of cognitive impairment and psychiatric symptom on daily functioning in nursing facilities: a longitudinal study Quality of life in patients with traumatic brain injury-basic issues, assessment and recommendations Neurocognitive impairment influences quality of life in HIV-infected patients receiving HAART Cognitive impairment in adults with good recovery after bacterial meningitis Factors associated with perceived quality of life many years after traumatic brain injury Instrumental activities of daily living: a stepping stone towards Alzheimer's disease diagnosis in subjects with mild cognitive impairment? keywords: care; dementia; depression; following; icu; impairment; patients; screening; survivors cache: cord-005606-c8c2rfzi.txt plain text: cord-005606-c8c2rfzi.txt item: #96 of 2876 id: cord-005646-xhx9pzhj author: None title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72090 flesch: 51 summary: Objective: To assess the normal ,gastric intramucosal pH ~Hi) by tonometry in healthy children Patients and methods: Twelve healthy children (6 males and 6 females) with age rmaged from 6 months to 12 years scheduled for minor plastic or urologic surgery. Pain relief was good (VRS less 2) in 53 children -94.6 % of study patients. keywords: acute; administration; admission; age; airway; analysis; ards; arterial; average; babies; blood; brain; cardiac; care; cases; changes; chest; children; complications; conclusion; cpb; criteria; data; days; death; diagnosis; difference; disease; dose; drug; duration; ecmo; effects; failure; flow; gas; group; heart; high; hospital; hours; hypertension; icu; ill; incidence; increase; infants; infusion; initial; injury; intensive; levels; life; lung; management; mean; measurements; mechanical; median; medical; methods; minutes; months; mortality; neonatal; neonates; newborns; nitric; non; nurses; outcome; oxide; oxygenation; parameters; patients; peak; pediatric; period; phi; picu; plasma; post; present; pressure; prism; pulmonary; range; rate; response; results; risk; score; sepsis; severe; severity; study; support; surgery; survivors; syndrome; system; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; weeks; weight; years cache: cord-005646-xhx9pzhj.txt plain text: cord-005646-xhx9pzhj.txt item: #97 of 2876 id: cord-005692-n4vxazst author: Papazian, Laurent title: Ventilator-associated pneumonia in adults: a narrative review date: 2020-03-10 words: 10366 flesch: 22 summary: The 2017 IDSA/ATS guidelines recommend empiric coverage of methicillin-resistant Staphylococcus aureus (MRSA) in patients who received antibiotics in the preceding 90 days or those hospitalized in units with high (> 20%) or unknown MRSA prevalence among VAP patients Although all-cause mortality associated with VAP has been reported to be as high as 50%, there is still considerable controversy regarding the extent to which VAP contributes to death in ICU patients. keywords: analysis; antibiotics; care; icu; mortality; pathogens; patients; pneumonia; prevention; rates; risk; study; treatment; trial; use; vap; ventilator cache: cord-005692-n4vxazst.txt plain text: cord-005692-n4vxazst.txt item: #98 of 2876 id: cord-005697-l1zmrq4p author: Pène, Frédéric title: Is this critically ill patient immunocompromised? date: 2015-12-02 words: 1346 flesch: 21 summary: Timing and causes of death in septic shock Genetic influences on incidence and case-fatality of infectious disease Epigenetic programming of monocyteto-macrophage differentiation and trained innate immunity The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy Reactivation of multiple viruses in patients with sepsis Innate immune dysfunction in trauma patients: from pathophysiology to treatment Temporary withdrawal of immunosuppression for life-threatening infections after liver transplantation Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebocontrolled multicenter trial Elevated plasmatic level of soluble IL-7 receptor is associated with increased mortality in septic shock patients Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock IL-7 restores lymphocyte functions in septic patients Case series and small trials indicate that immunostimulating compounds are able to restore immune function and may exert beneficial clinical effects in sepsis patients, while no overt safety issues have been reported [12, 13] . keywords: infections; patients; response; sepsis cache: cord-005697-l1zmrq4p.txt plain text: cord-005697-l1zmrq4p.txt item: #99 of 2876 id: cord-005705-j765ruj1 author: Dreyfuss, Didier title: Is it better to consent to an RCT or to care?: Μηδεν αγαν (“nothing in excess”) date: 2004-12-17 words: 7512 flesch: 42 summary: United States Government Printing Office Unraveling the Tuskegee study of untreated syphilis The therapeutic orientation to clinical trials The integral role of clinical research in clinical care Is informed consent always necessary for randomized, controlled trials? Resolving discordant meta-analyses Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis Clinicians' approaches to mechanical ventilation in acute lung injury and ARDS The price of autonomy Principles of medical ethics Why immunomodulatory therapies have not worked in sepsis Safeguarding patients in clinical trials with high mortality rates Is the concept of informed consent applicable to clinical research involving critically ill patients? Ethical considerations for research in critically ill patients Do surrogate decision makers provide accurate consent for intensive care research? keywords: ards; care; consent; evidence; investigators; patients; rcts; research; studies; study; trials; validity cache: cord-005705-j765ruj1.txt plain text: cord-005705-j765ruj1.txt item: #100 of 2876 id: cord-005717-x7gsqlwp author: Hauser, Gabriel J. title: Pediatric intestinal and multivisceral transplantation: a new challenge for the pediatric intensivist date: 2008-05-24 words: 5193 flesch: 26 summary: We reviewed the literature on intensive care of pediatric intestinal transplantation as well as our own experience. Methods: We reviewed the literature on intensive care of pediatric intestinal transplantation as well as our own experience. keywords: care; disease; failure; function; graft; itx; liver; patients; pediatric; post; rejection; transplantation cache: cord-005717-x7gsqlwp.txt plain text: cord-005717-x7gsqlwp.txt item: #101 of 2876 id: cord-005727-li8pwigg author: None title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 words: 102900 flesch: 50 summary: Postoperative sedation with both midazolam and dexmedetomidine were effective in suppressing oxidative stress in ICU patients. Poorly controlled pain in the postoperative period can lead to slow recovery and life threatening complications, especially in elderly patients. The use of a tidal volume of 6 ml/kg of predicted body weight is part of the management of patients presenting with ARDS (1) and prevents ventilator induced lung injury in ICU patients undergoing mechanical ventilation (2) . keywords: acute; admission; adult patients; age; aim; analysis; apache; arrest; arterial; assessment; blood; brain; cardiac; care; care patients; care unit; changes; complications; conclusions; control; critical; daily; data; days; diagnosis; differences; discharge; disease; early; effects; factors; failure; family; flow; fluid; following; glucose; group; hospital; hospital mortality; hypothermia; icu admission; icu mortality; icu patients; incidence; increased; infection; injury; intensive; introduction; invasive; length; levels; lung; management; mean; measurement; median; medical; methods; min; mmol; model; monitoring; mortality; n =; niv; non; number; nurses; objectives; organ; outcome; oxygen; p =; parameters; patients; pct; period; post; pressure; prospective; range; rate; results; risk; score; sedation; sepsis; septic; shock; staff; stay; studies; study; support; surgery; survival; system; temperature; test; therapy; time; total; treatment; unit; use; value; vap; variables; ventilation; volume; years cache: cord-005727-li8pwigg.txt plain text: cord-005727-li8pwigg.txt item: #102 of 2876 id: cord-005750-54hul2lw author: Antonelli, Massimo title: Year in review in Intensive Care Medicine, 2008: III. Paediatrics, Ethics, outcome research and critical care organization, sedation, pharmacology and miscellanea date: 2009-02-10 words: 8237 flesch: 41 summary: Policies were not modified for child patients in 9% of ICUs, nor for a dying patient in 21%. [36] review a few recent randomized clinical trials performed on severely ill patients (the ARMA trial comparing a low and a lage Vt in ARDS, the trial assessing the effect of growth hormone in ICU patients and the TRICC trial, on the level of blood transfusion, also in ICU patients) and emphasise the crucial importance of the control group. keywords: acute; authors; cardiac; care; children; critical; end; et al; icu; intensive; life; mortality; paediatric; patients; risk; shock; study; use cache: cord-005750-54hul2lw.txt plain text: cord-005750-54hul2lw.txt item: #103 of 2876 id: cord-005777-6rvfsx4p author: None title: PS 0420-0716 date: 2007-08-25 words: 59296 flesch: 50 summary: The aim of this study was to determine the risk factors and mortality rate of acinetobacter baumanii infections in ICU patients. It has been considered to play a role in worsening the prognosis of ICU patients. keywords: acute; admission; age; aim; analysis; apache; ards; ards patients; arterial; blood; cardiac; care; cases; complications; conclusion; control; data; days; dose; factors; failure; function; group; hospital; hours; icu; icu mortality; icu patients; incidence; increase; infection; infusion; injury; intensive; lactate; length; levels; liver; lung; mean; median; medical; mortality; non; outcome; parameters; patients; peep; period; pneumonia; pressure; pts; pulmonary; rate; ratio; results; risk; score; sepsis; septic; serum; shock; stay; study; surgery; test; therapy; time; total; tracheostomy; treatment; unit; use; values; ventilation; years cache: cord-005777-6rvfsx4p.txt plain text: cord-005777-6rvfsx4p.txt item: #104 of 2876 id: cord-005795-sgi54hq8 author: Ely, E. title: The impact of delirium in the intensive care unit on hospital length of stay date: 2001-11-08 words: 4880 flesch: 36 summary: In this investigation, we found that ICU patients had an inordinately high number of risk factors to develop delirium. Patients with three or more of these risk factors have been considered ªhigh riskº for delirium [2, 14, 40, 43] , and in ICU patients, this magnitude of risk is nearly universal. keywords: care; delirium; hospital; icu; length; patients; risk; stay; study cache: cord-005795-sgi54hq8.txt plain text: cord-005795-sgi54hq8.txt item: #105 of 2876 id: cord-005808-w0763esk author: Moreno, Gerard title: Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study date: 2018-08-03 words: 5152 flesch: 33 summary: Because Cox hazard survival analysis is not satisfactory for describing ICU patient mortality over time [33] , we performed a competing risks analysis to confirm our results. Therefore, the aim of the present study was to identify the factors associated with corticosteroid use and its impact on intensive care unit (ICU) mortality using propensity score (PS) matching analysis in ICU patients with influenza pneumonia. keywords: analysis; corticosteroid; data; hospital; icu; infection; influenza; mortality; patients; pneumonia; study; therapy; treatment; use cache: cord-005808-w0763esk.txt plain text: cord-005808-w0763esk.txt item: #106 of 2876 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #107 of 2876 id: cord-005816-i54q5gsu author: None title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 words: 83218 flesch: 50 summary: Liberal utilization of abdominal sonography and abdominal CT scan may reduce missed acute abdomen in abdominal pain patients and appropriate radiological imaging and meticulous evaluation of the X-rays may reduce unnoticed spinal, pelvic and facial fractures in trauma patients. The e-mail noticed us, the presenting author of this abstract (Akira Endo) posted 3 or more abstract as a presenting author, however, the authors of 'Increased mortality in trauma patients with systolic hypertension' believed that Akira Endo in Department of ACCDM, TMDU, Japan surely posted this abstract only. keywords: abdomen; abdominal; acute; admission; age; aim; appendicitis; approach; area; artery; average; bleeding; blood; blunt; bone; burn; burn patients; care; cases; cause; chest; colon; complications; conclusion; control; data; days; department; diagnosis; disease; emergency; evaluation; examination; factors; female; findings; fixation; follow; fractures; general; good; group; head; healing; hospital; infection; initial; injuries; injury; introduction; knee; laparotomy; left; liver; male; management; mean; medical; methods; months; morbidity; mortality; n =; number; operation; outcome; p =; pain; patients; penetrating; perforation; period; postoperative; present; procedure; range; rate; reduction; results; right; risk; score; second; severity; stay; study; surgery; system; technique; time; tissue; total; trauma patients; treatment; type; weeks; wound; years cache: cord-005816-i54q5gsu.txt plain text: cord-005816-i54q5gsu.txt item: #108 of 2876 id: cord-005819-fp5khzd5 author: Bonatz, K. title: Gram-negative bacterial pneumonia with secondary aspergillosis in an AIDS patient date: 1991 words: 1656 flesch: 34 summary: fungal infections Oral corticosteroids prevent acute respiratory failure in AIDS-related Pneumocystis carinii pneumonia (abstract) Bacterial infections in the acquired immune deficiency syndrome Opportunistic infections and malignancies in 231 Danish AIDS patients Bacterial infections in AIDS patients Aspergillus findings in AIDS patients suffering from cryptococcosis Value of necropsy in acquired immunodeficiency syndrome Aspergillus infection of the central nervous system in patients with acquired immunodeficiency syndrome The cases of AIDS patients with invasive aspergillosis described in the literature therefore had neutropenia related to zidovudine or to ganciclovir therapy, increased exposure to aspergillus by marijuana smoking, underlying pulmonary disease, or corticosteroid use as predisposing factors. keywords: aids; aspergillosis; patient; pneumonia; therapy cache: cord-005819-fp5khzd5.txt plain text: cord-005819-fp5khzd5.txt item: #109 of 2876 id: cord-005861-3k8h3euj author: Gravenstein, J. S. title: Safety in anesthesia date: 2014-03-17 words: 3660 flesch: 47 summary: key: cord-005861-3k8h3euj authors: Gravenstein, J. S. title: Safety in anesthesia date: 2014-03-17 journal: Anaesthesist DOI: 10.1007/s00101-002-0319-4 sha: doc_id: 5861 cord_uid: 3k8h3euj The specialty of anesthesiology has made extraordinary advances in anesthesia safety. Such safety standards have become much more elaborate during the last decades and can be found in many countries. keywords: analysis; anesthesia; equipment; operating; outcome; patient; pressure; safety; standards; system cache: cord-005861-3k8h3euj.txt plain text: cord-005861-3k8h3euj.txt item: #110 of 2876 id: cord-005881-oswgjaxz author: None title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 words: 72013 flesch: 48 summary: The aim of this study was therefore to establish the impact of anaemia and blood transfusion on postoperative recovery of hip fracture patients. We assessed the adherence of these guidelines on the initial pre-operative management of tetanus prone open orthopaedic injuries in trauma patients admitted for surgery. keywords: acute; age; aim; analysis; approach; average; bone; care; cases; complications; conclusion; control; data; days; difference; disclosure; emergency; evaluation; failure; fixation; follow; fracture patients; fractures; good; group; head; healing; hospital; incidence; infection; injuries; injury; introduction; knee; liver; long; management; material; mean; medical; methods; months; mortality; nail; non; number; operation; operative; osteosynthesis; outcome; pain; patients; period; plate; postoperative; procedure; range; rate; reduction; relationships; repair; results; risk; score; screw; standard; stiffness; studies; study; surgery; system; technique; tibial; time; tissue; total; training; trauma patients; treatment; type; use; weeks; wound; years cache: cord-005881-oswgjaxz.txt plain text: cord-005881-oswgjaxz.txt item: #111 of 2876 id: cord-005953-5z89yeb6 author: None title: Abstracts des 114. Internistenkongresses 2008 date: 2008 words: 16191 flesch: 40 summary: Hohe Prävalenz der ASS-Non-Responder bei ACVB-Patienten in den multiplen Testanalysen Hintergrund und Zielsetzung: In der Therapie der HIV-Infektion sind Wechselwirkungen und Unverträglichkeit der mittlerweile zahlreich zur Verfügung stehenden antiretoviralen Medikamente ein grosses Problem. Auch in der Subgruppe der überlebenden keywords: als; apoptose; auf; baseline; bei; cells; cholesterol; class; clopidogrel; combination; das; dem; der; des; diabetes; die; disease; durch; eine; ergebnisse; expression; fat; für; glucose; group; gruppe; hbv; heart; hzv; ifn; ist; jedoch; ldl; methoden; methods; min; mit; mittels; mmhg; nach; nicht; non; p<0.05; patienten; patients; platelets; protein; reduction; results; schlussfolgerung; sind; studie; study; system; therapie; therapy; tolerance; treatment; type; und; unter; untersucht; vascular; vivo; von; war; werden; wurde; zellen; zur; über cache: cord-005953-5z89yeb6.txt plain text: cord-005953-5z89yeb6.txt item: #112 of 2876 id: cord-005992-mu917isy author: None title: Abstracts der 49. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2011-10-23 words: 19302 flesch: 46 summary: Es wurden Methylprednisolonstöße verabreicht und eine Plasmapherese an drei aufeinanderfolgenden Als Methodik dienten das Clown-Prinzip und der mythischen Heldenkreis. keywords: abteilung; act; age; als; alter; arousals; asthma; auch; auf; aus; background; bei; bei der; bereits; bis; bzw; case; cells; children; conclusion; das; dass; daten; days; dem; der; des; diabetes; diagnose; diagnosis; die; diese; disease; durch; eine; ergebnisse; esbl; form; function; für; für die; gegen; group; haben; hintergrund; infection; initial; ist; jahren; jugendheilkunde; kam; kann; kinder; konnte; können; levels; mean; median; medizinische; methods; mit; mit der; months; mutation; nach; nicht; normal; nur; oder; ohne; patienten; patients; pcr; pdf; pädiatrische; report; results; schlussfolgerung; screening; sehr; sepsis; severe; sich; sind; sollte; sowie; studie; study; therapie; therapy; treatment; und; universität; universitätsklinik; unter; von; vor; vs.; war; waren; werden; wien; wird; wurde; während; year; zeigte; ziel; zum; zur; zwischen; über cache: cord-005992-mu917isy.txt plain text: cord-005992-mu917isy.txt item: #113 of 2876 id: cord-006000-ekwpkzqv author: Bewig, B. title: Eosinophilic alveolitis in BAL after lung transplantation date: 1999 words: 4209 flesch: 37 summary: The histological changes in transbronchial biopsy after treatment of acute lung rejection in heart-lung transplants Bronchoalveolar lavage and transbronchial lung biopsy during acute rejection and infection in heart-lung transplant patients Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion Bronchoalveolar lavage in allergic asthmatics Study of eosinophilia and hepatic dysfunctionas a predictor of rejection in human liver transplantation Non-invasive parameters for detection of cardiac allograft rejection Cytokine production at the site of disease in chronic eosinophilic pneumonitis Immunocytologic analysis of cells obtained from bronchoalveolar lavage in a model of rat lung allograft rejection Partcipation of interleukin-5 and interleukin-8 in the eosinophil migration induced by a large volume of saline Prognostic role of eosinophils in pulmonary fibrosis Activation of eosinophils and fibroblasts assessed by eosinophil cationic crotein and hyaluronan in BAL. Analysis of BAL fluid BAL fluid was transported to the laboratory within 1 h for immediate processing. keywords: acute; alveolitis; bal; eosinophilic; episodes; il-5; lung; patients; rejection; transplantation cache: cord-006000-ekwpkzqv.txt plain text: cord-006000-ekwpkzqv.txt item: #114 of 2876 id: cord-006179-7uv4yfv2 author: Cheuk, Daniel Ka Leung title: Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children date: 2007-09-29 words: 4586 flesch: 43 summary: Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents Chemosensitivity of central nervous system tumors to thiotepa and tepa Therapeutic profile of the human glioma line D-54 MG in athymic mice High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. However, the cure rate remains poor in some high-risk histological types, and for patients with residual, recurrent or disseminated disease. keywords: ahsct; chemotherapy; disease; dose; patients; remission; transplant; tumors cache: cord-006179-7uv4yfv2.txt plain text: cord-006179-7uv4yfv2.txt item: #115 of 2876 id: cord-006181-fkh2fzbr author: Bednarczyk, Joseph M. title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 words: 3536 flesch: 33 summary: Despite lung protective ventilation strategies with maximal F(i)O(2) (patients A-D), neuromuscular blockade (patients A-D), inhaled nitric oxide (patients A and D), and prone positioning (patient D), progressive hypoxemia resulted in initiation of venovenous ECMO by hours 24-90 of mechanical ventilation with subsequent de-escalation of ventilatory support. Life-threatening hypoxemia, acidosis, and injurious airway pressures developed despite 100% F I O 2 (patients A-D), neuromuscular blockade (patients A-D), inhaled nitric oxide at 20 ppm (patients A and D), and prone positioning (patient D) ( Table 2 ). keywords: ards; blastomycosis; ecmo; extracorporeal; lung; membrane; oxygenation; patients; support; ventilation cache: cord-006181-fkh2fzbr.txt plain text: cord-006181-fkh2fzbr.txt item: #116 of 2876 id: cord-006182-kck5e1ry author: None title: 17th Annual Meeting, Neurocritical Care Society, October 15–18, 2019, Vancouver, Canada date: 2019-10-01 words: 87787 flesch: 45 summary: Whether a laboratory response in coagulation dosing, laboratory response, hemostatic efficacy and patient outcomes. A project aimed at improving DI management through predictive assessments and DDAVP protocols could potentially improve patient outcomes. keywords: acute; admission; adult patients; analysis; arrest; arrest patients; asah; associated; association; baseline; blood; brain; brain injury; cardiac; care; case; center; cerebral; changes; cohort; common; complications; data; days; dci; death; diagnosis; difference; discharge; disease; dose; edema; eeg; factors; functional; gcs; group; hemorrhage; higher; hospital; hours; ich patients; icp; icu; imaging; improvement; initial; injury; intervention; intracranial; ischemic; left; levels; management; mean; median; medical; monitoring; mortality; mri; mrs; neurocritical; new; non; outcome; patients; post; pressure; primary; rate; related; results; review; risk; sah; sah patients; scale; score; seizures; status; stroke; stroke patients; studies; study; subarachnoid; tbi patients; test; therapeutic; therapy; time; total; treatment; ttm; unit; use; vasospasm; years cache: cord-006182-kck5e1ry.txt plain text: cord-006182-kck5e1ry.txt item: #117 of 2876 id: cord-006226-fn7zlutj author: None title: Abstracts of the 4th annual meeting of the German Society of Clinical Pharmacology and Therapy: Hannover, 14–17 September 1994 date: 1994 words: 25130 flesch: 47 summary: The effects were correlated with the %-~l-adrenoceptor occupancies estimated using a standard Emax-model (sigmoidicity=l) from the concentrations of active substrate in plasma determined by I~l-adrenoceptor specific radioreceptor assay. With regard to group I) the highest expenditures nccured in hospitals A and B whereas drug costs in C -E were 1/3 less and came to only 20% in hospital F. keywords: acid; activity; aggregation; blood; cell; clinical; concentrations; cost; data; disease; dose; drug; effects; excretion; function; group; hours; human; inhibition; mean; metabolites; method; min; patients; placebo; plasma; platelet; products; protein; rate; release; results; samples; serum; studies; study; therapy; time; total; treatment; urinary; urine; use; vitro; volunteers cache: cord-006226-fn7zlutj.txt plain text: cord-006226-fn7zlutj.txt item: #118 of 2876 id: cord-006236-2gpwf4z2 author: None title: Abstracts from the First International Conference on Heart Failure in Children and Young Adults date: 2004 words: 13120 flesch: 51 summary: Key words: heart failure, outpatient, and inotropic therapy Congestive heart failure is still a major health problem in pediatric patients. We report our experience with IABP to support pediatric cardiac patients. keywords: age; bnp; cardiac; cardiomyopathy; children; days; ecmo; failure; function; group; heart; mean; median; patients; pediatric; pts; range; results; support; vad; ventricular; years cache: cord-006236-2gpwf4z2.txt plain text: cord-006236-2gpwf4z2.txt item: #119 of 2876 id: cord-006302-pnnkfid0 author: Ioakeimidou, A. title: Increase of circulating endocan over sepsis follow-up is associated with progression into organ dysfunction date: 2017-04-28 words: 2947 flesch: 48 summary: Community-and healthcareassociated infections in critically ill patients: a multicenter cohort study The third international consensus definitions for sepsis and septic shock (sepsis-3) Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy Angiopoietins in angiogenesis and beyond Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity SIS international sepsis definitions conference The international sepsis forum consensus definitions of infections in the intensive care unit Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines Endothelial cell-specific molecule-1/endocan: diagnostic and prognostic value in patients suffering from severe sepsis and septic shock Identification of a 14kDa fragment generated by cathepsin G, a novel circulating biomarker in sepsis Endocan, a new endothelial marker in human sepsis Characteristics of serum endocan levels in infection Lower serum endocan levels are associated with the development of acute lung injury after major trauma Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients Endocan is a useful biomarker of survival and severity in sepsis Endocan levels in peripheral blood predict outcomes of acute respiratory distress syndrome Inhibition of caspase-1 activation in gram-negative sepsis and experimental endotoxemia Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study Endocan and Ang-2 were the only parameters that were significantly increased among patients who worsened. keywords: baseline; endocan; increase; organ; patients; sepsis; study cache: cord-006302-pnnkfid0.txt plain text: cord-006302-pnnkfid0.txt item: #120 of 2876 id: cord-006332-ikh45wuy author: Bengmark, Stig title: Nutritional Support to Prevent and Treat Multiple Organ Failure date: 1996 words: 6921 flesch: 38 summary: Baterial metabolites in feces and urine Effect of pectin on jejunal glucose absorption and unstirred layer thickness in normal man Interaction of nutrition and infection Effect of two feeding formulas on immune responses and mortality in mice challenged with Listeria monocytogenes Febrile and plasma iron responses of rabbits injected with endogenous pyrogen from malnourished patients NK cell activity and protein intake in an aflatoxin B 1 (AF)-induced tumor model Dietary modulation of cytokine production and biologic function Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin Tumor necrosis factor-Ѩ alters phospholipid content in the bronchoalveolar lavage-accessible space of isolated perfused rat lungs Tumor necrosis factor-Ѩ-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cell to H 2 O 2 N G -Methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide Protective and pathological roles of nitric oxide in endotoxin shock Methylene blue administration in septic shock: a clinical trial Bacterial translocation after thermal injury Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure Stomach NO synthesis Nitric oxide release accounts for biologic activity of endothelium-derived relaxing factor Nitric oxide donors increase mucus gel thickness in rat stomach Inflammatory host responses in sepsis Longitudinal analysis of neutrophil superoxide anion generation in patients with septic shock Aggressive nutritional support does not prevent protein loss despite fat gain in septic intensive care patients Perioperative parenteral nutrition: a meta-analysis Nutritional outcome and pneumonia in critical care patients randomized to gastric versus jejunal tube feedings Do weighted nasoenteric feeding tubes facilitate duodenal intubations? Technical developments: a new self-propelling nasoenteric feeding tube Differential effects of three enteral dietary regimens on selected outcome variables in burn patients Antibiotic resistant Pseudomonas in bottled drinking water Antibiotic resistance of Pseudomonas from German mineral waters. IL-6 in septic patients has a late peak that correlates with a fatal outcome. keywords: acids; arginine; bacteria; colonic; enteral; feeding; fiber; gastric; hours; important; intestinal; mucosa; nutrition; patients; production; sepsis; septic; translocation cache: cord-006332-ikh45wuy.txt plain text: cord-006332-ikh45wuy.txt item: #121 of 2876 id: cord-006343-c0amee70 author: Martinez Rivera, Andrea title: Intestinal transplantation in children: current status date: 2016-03-31 words: 4983 flesch: 36 summary: The International Intestinal Transplant Registry report of the intestine transplant registry: a new era has dawned Impact of intestinal rehabilitation program and its innovative therapies on the outcome of intestinal transplant candidates Pediatric intestinal failure associated liver disease is reversed with 6 months of intravenous fish oil Recent advances in the management of pediatric intestinal failure Novel lipid-based approaches to pediatric intestinal failure-associated liver disease Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome Management of pediatric intestinal failure Reversal of intestinal failure-associated liver disease by switching from a combination lipid emulsion containing fish oil to fish oil monotherapy Ethanol locks to prevent catheter-related bloodstream infections in parenteral nutrition: a meta-analysis Prevention of catheter-related blood stream infections in children with intestinal failure ASPEN clinical guidelines: support of pediatric patients with intestinal failure at risk of parenteral nutrition-associated liver disease Delayed primary serial transverse enteroplasty as a novel management strategy for infants with congenital ultrashort bowel syndrome Five-year outcomes after serial transverse enteroplasty in children with short bowel syndrome Indications for pediatric intestinal transplantation: a position paper of the American Society of Transplantation 25 years of pediatric follow-up Pediatric intestinal transplant listing criteria-a call for a change in the new era of intestinal failure outcomes Intestine transplantation in the United States The current state of intestine transplantation: indications, techniques, outcomes and challenges Successful small-bowel/liver transplantation A new technique for combined liver/ small intestinal transplantation Noncomposite simultaneous liver and intestinal transplantation Inclusion of donor colon and ileocecal valve in intestinal transplantation Inclusion of the colon in intestinal transplantation Optimal management of the post-intestinal transplant patient Longterm outcome, growth and digestive function in children 2-18 years after intestinal transplantation Long-term nutrition and predictors of growth and weight gain following pediatric intestinal transplantation Intestinal transplantation Mucosal plasma cell barrier disruption during intestine transplant rejection Histological criteria for the identification of acute cellular rejection in human small bowel allografts: results of the pathology workshop at the VIII International Small Bowel Transplant Symposium The value of plasma citrulline to predict mucosal injury in intestinal allografts Citrulline level is a potent indicator of acute rejection in the long term following pediatric intestinal/multivisceral transplantation Stool calprotectin monitoring after small intestine transplantation Infliximab as salvage therapy in paediatric intestinal transplant with steroidand thymoglobulin-resistant late acute rejection Pretransplant predictors of survival after intestinal transplantation: analysis of a single-center experience of more than 100 transplants Successful isolated intestinal transplantation in sensitized recipients with the use of virtual crossmatching Eculizumab salvage therapy for antibody-mediated rejection in a desensitization-resistant intestinal re-transplant patient FK 506 for liver, kidney, and pancreas transplantation Intestinal and multivisceral transplantation immunosuppression protocols-literature review Intestinal and multivisceral transplantation in children Chronic rejection of small bowel grafts: pediatric and adult study of risk factors and morphologic progression Chronic rejection. key: cord-006343-c0amee70 authors: Martinez Rivera, Andrea; Wales, Paul W. title: Intestinal transplantation in children: current status date: 2016-03-31 journal: Pediatr Surg Int DOI: 10.1007/s00383-016-3885-2 sha: doc_id: 6343 cord_uid: c0amee70 Intestinal transplantation (IT) is the least common form of organ transplantation; however, it has shown exceptional growth and improvement in graft survival rates over the past two decades mainly due to better outcomes achieved during the first year of transplantation (76 % at 1 year), due to improvement in surgical techniques and the development of better immunosupressive therapies as we understand more about the relationship between the recipient and host immune system. keywords: bowel; failure; graft; intestine; life; liver; patients; pediatric; rejection; survival; transplantation cache: cord-006343-c0amee70.txt plain text: cord-006343-c0amee70.txt item: #122 of 2876 id: cord-006344-de4dhv4b author: Seitsonen, E. title: Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection date: 2006-03-21 words: 2776 flesch: 45 summary: The two Table 2 Platelet counts (PC, ×10 9 /l) and C-reactive protein values (CRP, mg/l) in cases 1 and 2 on consecutive days POS during the period of ICU treatment (days 7-21 POS and 5-15 POS for cases 1 and 2, respectively) survivors who required mechanical ventilation were extubated after 5 days and made a full recovery. [18] demon-strated that at the onset of pulmonary edema, HPS patients have abundant viremia which clears rapidly after the resolution of fever, while respiratory distress may persist. keywords: day; days; hantavirus; patient; pos; syndrome; treatment cache: cord-006344-de4dhv4b.txt plain text: cord-006344-de4dhv4b.txt item: #123 of 2876 id: cord-006363-xov4xwpa author: Lu, Gen title: Study of Acute Exogenous Lipoid Pneumonia date: 2016-01-29 words: 3100 flesch: 41 summary: key: cord-006363-xov4xwpa authors: Lu, Gen; Xie, Yaping; Huang, Li; Tong, Zhijie; Xie, Zhiwei; Yu, Jialu; Wu, Peiqiong title: Study of Acute Exogenous Lipoid Pneumonia date: 2016-01-29 journal: Indian J Pediatr DOI: 10.1007/s12098-015-2028-4 sha: doc_id: 6363 cord_uid: xov4xwpa OBJECTIVE: To analyze the clinical and imagenological characteristics of acute Exogenous lipoid pneumonia (ELP), explore its risk factors, and assess the potential role of multiple bronchoalveolar lavages (BALs) and steroid therapy in the treatment of children with acute ELP. METHODS: Between May 2011 and July 2014, 33 pediatric patients with pneumonia caused by aspiration of oil-based substances were admitted to the Guangzhou Women and Children’s Medical Center, Guangdong, China. Secondary bacterial infection is common in acute ELP, but infection was detected in only four patients in the BAL culture, even though most patients presented with fever, leukocytosis, neutrophilia, and elevation of C-reactive protein levels in the serum. keywords: acute; cases; elp; lipoid; oil; patients; pneumonia cache: cord-006363-xov4xwpa.txt plain text: cord-006363-xov4xwpa.txt item: #124 of 2876 id: cord-006391-esnsa4u5 author: None title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 words: 44873 flesch: 47 summary: Control patients (no ASA) were compared to those receiving 80 or 325 mg. After transplantation patients were followed for a minimum of 3 months and a maximum of 42 months. keywords: acid; activity; acute; animals; bile; blood; blood flow; body; bypass; cases; cells; changes; control; days; dogs; duct; effect; failure; flow; gastric; glucose; graft; group; heart; hepatic; increase; infusion; insulin; kidney; levels; liver; mean; method; min; months; non; normal; operation; patients; plasma; postoperative; present; pressure; rate; rats; rejection; response; results; serum; studies; study; surgery; survival; time; tissue; total; transplantation; treatment; tumor; values; vascular; weeks; weight cache: cord-006391-esnsa4u5.txt plain text: cord-006391-esnsa4u5.txt item: #125 of 2876 id: cord-006394-ucthbqvt author: Pawlik, Timothy M. title: Combined Resection and Radiofrequency Ablation for Advanced Hepatic Malignancies: Results in 172 Patients date: 2003 words: 6138 flesch: 41 summary: Other factors such as age, number of RFA tumors, type of surgery, and total number of tumors treated did not significantly affect survival on univariate analysis (all P Ͼ .05). In general, most data concerning RFA treatment of hepatic tumors has come from studies involving patients with unresectable disease who have had RFA as primary therapy. keywords: disease; liver; metastases; patients; resection; rfa; survival; treatment; tumors cache: cord-006394-ucthbqvt.txt plain text: cord-006394-ucthbqvt.txt item: #126 of 2876 id: cord-006426-baf2d47y author: Kimura, Fumio title: Immunosuppression following surgical and traumatic injury date: 2010-08-26 words: 9873 flesch: 31 summary: An aggressive surgical approach leads to improved survival in patients with gallbladder cancer: a 12-year study at a North American Center Bacteremia after hepatectomy: an analysis of a singlecenter, 10-year experience with 407 patients Pancreaticoduodenectomy: a 20-year experience in 516 patients Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality Organ-preserving surgery for benign lesions and low-grade malignancies of the pancreatic head: a matched case-control study Surgical trauma and immunosuppression: pathophysiology and potential immunomodulatory approaches Cell response to surgery The immunological consequences of injury Systemic infl ammation after trauma Immunologic dissonance: a continuing evolution in our understanding of the systemic infl ammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS) Evolving concepts in the pathogenesis of postinjury multiple organ failure The early second hit in trauma management augments the proinfl ammatory immune response to multiple injuries Interleukin-6 in the injured patient. Therefore, even in the absence of pathogens, disrupted or injured cells recruit innate infl ammatory cells by releasing DAMPs. keywords: activation; ammatory; associated; cells; expression; infection; infl; injury; levels; macrophages; monocytes; patients; receptors; response; role; sepsis; septic; shock; surgery; trauma cache: cord-006426-baf2d47y.txt plain text: cord-006426-baf2d47y.txt item: #127 of 2876 id: cord-006444-eq56zhtd author: None title: Abstracts of oral presentations and posters date: 1993 words: 40759 flesch: 49 summary: The shortened NTT was also reflected by a decreased proportion of marrow cells in the post mitotic pool (metas, bands and PMNs) and apparently lengthened blood The application of r-canine G-CSF enhanced the recovery of granulocytes but led to graft failure in dogs receiving a low number of marrow cells. keywords: activity; administration; blood; bone; cells; chemotherapy; clinical; colony; combination; control; csf; cytokines; days; disease; dose; effects; expression; factor; group; growth; human; ifn; il-2; il-3; il-6; increase; levels; marrow; median; neutropenia; non; normal; number; patients; phase; production; proliferation; protein; pts; response; results; rhg; role; serum; stem; stimulation; studies; study; tnf; treatment; tumor; vitro cache: cord-006444-eq56zhtd.txt plain text: cord-006444-eq56zhtd.txt item: #128 of 2876 id: cord-006460-3ayc0hne author: Baue, Arthur E. title: Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients date: 2000-10-19 words: 8385 flesch: 53 summary: The three major reasons that I described earlier for the discrepancy between science and patient care also apply here. I have now reviewed the third reason for the discrepancy between excellent science and patient care. keywords: care; differences; disease; failure; mof; mortality; organ; patients; response; sepsis; shock; sirs; syndrome; time; trauma; treatment cache: cord-006460-3ayc0hne.txt plain text: cord-006460-3ayc0hne.txt item: #129 of 2876 id: cord-006464-s8rjoyse author: Bauer, Michael title: Infectious and Immunologic Phenotype of MECP2 Duplication Syndrome date: 2015-02-27 words: 5420 flesch: 36 summary: Mb terminal Xq duplication involving MECP2 but not L1CAM gene in a male patient with mental retardation Distal Xq duplication and functional Xq disomy The clinical variability of the MECP2 duplication syndrome: description of two families with duplications excluding L1CAM and FLNA Xq28 duplication presenting with intestinal and bladder dysfunction and a distinctive facial appearance Structural variation in Xq28: MECP2 duplications in 1% of patients with unexplained XLMR and in 2% of male patients with severe encephalopathy Two brothers with a microduplication including the MECP2 gene: rapid head growth in infancy and resolution of susceptibility to infection Complex rearrangements in patients with duplications of MECP2 can occur by fork stalling and template switching Neurologic aspects of MECP2 gene duplication in male patients Dosage-dependent severity of the phenotype in patients with mental retardation due to a recurrent copy-number gain at Xq28 mediated by an unusual recombination Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome Four unrelated patients with Lubs X-linked mental retardation syndrome and different Xq28 duplications High frequency of nonrecurrent MECP2 duplications among Brazilian males with mental retardation MECP2 duplication in a patient with congenital central hypoventilation Progressive cerebellar degenerative changes in the severe mental retardation syndrome caused by duplication of MECP2 and adjacent loci on Xq28 De novo duplication of MECP2 in a girl with mental retardation and no obvious dysmorphic features Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis Novel association of severe neonatal encephalopathy and Hirschsprung disease in a male with a duplication at the Xq28 region Cryptic x; autosome translocation in a boydelineation of the phenotype MECP2 duplications in six patients with complex sex chromosome rearrangements De novo MECP2 duplication in two females with random Xinactivation and moderate mental retardation Novel clinical finding in MECP2 duplication syndrome De novo interstitial triplication of MECP2 in a girl with neurodevelopmental disorder and random X chromosome inactivation Inverted genomic segments and complex triplication rearrangements are mediated by inverted repeats in the human genome MECP2 triplication in 3 brothers -a rarely described cause of familial neurological regression in boys Japanese mental retardation consortium. Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation Searching for copy number changes in nonsyndromic X-linked intellectual disability Xq28 duplications including MECP2 in five females: expanding the phenotype to severe mental retardation The incidence of hypoplasia of the corpus callosum in patients with dup (X)(q28) involving MECP2 is associated with the location of distal breakpoints Characterization of six novel patients with MECP2 duplications due to unbalanced rearrangements of the X chromosome Electroclinical pattern in MECP2 duplication syndrome: eight new reported cases and review of literature A partial MECP2 duplication in a mildly affected adult male: a putative role for the 3′ untranslated region in the MECP2 duplication phenotype A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections Overexpression of methyl-CpG binding protein 2 impairs T(H)1 responses Clinical manifestations of Xq28 functional disomy involving MECP2 in one female and two male patients Second-trimester prenasal and prefrontal skin thickening -association with MECP2 triplication syndrome Brief report: regression timing and associated features in MECP2 duplication syndrome MECP2 duplication phenotype in symptomatic females: report of three further cases MECP2 duplication: possible cause of severe phenotype in females Clinical characterization and identification of duplication breakpoints in a Japanese family with Xq28 duplication syndrome including MECP2 The MECP2 duplication syndrome MECP2 duplication syndrome The main Aeromonas pathogenic factors The capsular polysaccharide complex of Bacteroides fragilis induces cytokine production from human and murine phagocytic cells Immunochemical and biological characterization of three capsular polysaccharides from a single Bacteroides fragilis strain Polysaccharide biosynthesis locus required for virulence of Bacteroides fragilis Capsulate bacteria and the lung Genome sequence of Klebsiella oxytoca M5al, a promising strain for nitrogen fixation and chemical production Capsule polysaccharide is a bacterial decoy for antimicrobial peptides Unique ability of the Proteus mirabilis capsule to enhance mineral growth in infectious urinary calculi The algR gene, which regulates mucoidy in Pseudomonas aeruginosa, belongs to a class of environmentally responsive genes Staphylococcus aureus capsular polysaccharides Encapsulated Staphylococcus aureus strains vary in adhesiveness assessed by atomic force microscopy Development of a vaccine against Staphylococcus aureus Capsular polysaccharides are an important immune evasion mechanism for Staphylococcus aureus Immune evasion by staphylococci The ica locus of Staphylococcus epidermidis encodes production of the capsular polysaccharide/adhesin Upregulation of capsule enables Streptococcus pyogenes to evade immune recognition by antigen-specific antibodies directed to the G-related alpha2-macroglobulin-binding protein GRAB located on the bacterial surface The importance of the group a streptococcus capsule in the pathogenesis of human infections: a historical perspective Thermoregulation of capsule production by Streptococcus pyogenes Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency Primary immunodeficiencies: a rapidly evolving story Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cellindependent type 2 antigens T-bet regulates T-independent IgG2a class switching keywords: duplication; ifny; iga; igg; infections; mecp2; patients; phenotype; retardation; secretion; syndrome; values; xq28 cache: cord-006464-s8rjoyse.txt plain text: cord-006464-s8rjoyse.txt item: #130 of 2876 id: cord-006466-e1phpqes author: None title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2018-04-23 words: 92405 flesch: 42 summary: Despite defective T cell signaling responses to chemokines (i.e., GPCR stimulation), chemotaxis of patient T cell blasts in vitro was normal. Proteasome assembly and catalytic function was assessed by SDS-PAGE and native gel respectively, using patient derived cell lines. keywords: age; analysis; antibody; autoimmune; b cells; background; blood; case; cd3; cd4; cd8; cgd; children; chronic; clinical; complications; conclusions; counts; cvid patients; cytometry; data; day; days; development; diagnosis; disease; disorders; dna; evaluation; expression; flow; function; gene; hct; heterozygous; history; hospital; hsct; hypogammaglobulinemia; iga; igg; igm; immune; immunodeficiency; immunoglobulin; infections; inflammatory; introduction; laboratory; levels; life; low; lung; lymphocyte; lymphopenia; marrow; mean; median; methods; months; mutation; negative; nk cells; non; normal; novel; number; objectives; onset; patients; phenotype; pid; population; positive; post; present; presentation; primary; protein; pulmonary; range; recurrent; reduced; replacement; report; response; results; scid; scid patients; sequencing; serum; skin; specific; studies; study; symptoms; syndrome; t cells; testing; therapy; time; total; transplant; treatment; vaccine; variant; weeks; years cache: cord-006466-e1phpqes.txt plain text: cord-006466-e1phpqes.txt item: #131 of 2876 id: cord-006508-rje9bnph author: Ballas, Samir K. title: Sickle Cell Anaemia: Progress in Pathogenesis and Treatment date: 2012-10-10 words: 14708 flesch: 42 summary: Five years of experience with hydroxyurea in children and young adults with sickle cell disease Clinical evaluation of a semi-permeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers Core decompression in avascular necrosis of the hip in sickle cell disease Long term results of total hip arthroplasty for osteonecrosis of the femoral head: a comparison with osteoarthritis Osteonecrosis of the hip in sickle cell diseases Total replacement of the hip for avascular necrosis in sickle cell disease Cholecystectomy in sickle cell anemia patients: Perioperative outcome of 364 cases from the National Preoperative Transfusion Study Cholecystectomy in adult patients with sickle cell disease Influence of bilirubin uridine diphosphate-glucoronosyltransferase 1A promotor polymorphisms on serum bilirubin levels and cholelithiasis in children with sickle cell anemia Genetic determinants of jaundice and gallstones in haemoglobin E b-thalassemia Exchange transfusion in sickle cell intrahepatic cholestasis Bone marrow transplantation for sickle cell disease Successful related cord blood transplantation for hemoglobinopathies Unrelated placental umbilical cord blood cell (UCBC) transplantation in children with high-risk sickle cell disease (SCD) Successful cord blood transplantation for sickle cell anemia from a sibling who is human leukocyte antigen-identical: implications for comprehensive care Correction of sickle cell disease in transgenic mouse models by gene therapy Hydroxyurea exposure alters mouse testicular kinetics and sperm chromatin structure Comparison of teratogenic effects of aspirin and hydroxyurea in the Fischer 344 and Wistar strains Severe developmental malformations: malformations induced by urethane and hydroxyurea in the hamster Acute leukemia (AL), hydroxyurea (HO) and polycythemia vera (PV): an analysis of risk and the Polycythemia Vera Study Group Fetal haemoglobin variations following hydroxyurea treatment in patients with cyanotic congenital heart disease A short-term trial of burtyate to stimulate fetal-globin-gene expression in the bglobin disorders Fetal hemoglobin induction with butyric acid: efficacy and toxicity Isobutyramide therapy in patients with sickle cell anemia Increased fetal hemoglobin in patients receiving sodium 4-phenylbutyrate Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy Stimulation of hemoglobin synthesis by erythropoietin in baboons Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease Granulocytosis causing sickle cell crisis Fatal sickle cell crisis after granulocyte colony-stimulating factor administration Granulocyte colony-stimulating factor-inducted sickle cell crisis and multiorgan dysfunction in a patient with compound heterozygous sickle cell b+ thalassemia Inhibition of Ca2+-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease Pulmonary hypertension in sickle cell disease and treatment with L-Carritine Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease Zileuton: a potential new treatment approach for acute chest syndrome Sickle cell anemia: a potential nutritional approach for a molecular disease Green tea extract and aged garlic extract inhibit potassium chloride co-transport in sickle cells in vitro, but Vitamin-C and Vitamin-E do not Hydration of sickle erythrocytes using a herbal extract (Pfaffia paniculata) in-vitro Department of Medicine, Cardeza Foundation for Hematologic Research Supported in part by the Sickle Cell Program of the Commonwealth of Pennsylvania, Harrisburg, Pennsylvania, USA. Basic principles and clinical picture Sickle cell anemia and major organ failure Beyond hemoglobin polymerization: The red blood cell membrane and sickle disease pathophysiology Vascular occlusion in sickle cell disease: Current concepts and unanswered questions Regulation of erythrocytes cation and water content in sickle cell anemia Cation transport and volume regulation in sickle red blood cells Prevention of red cell dehydration: a possible new treatment for sickle cell disease A mathematical model of the volume, pH1 and ion content regulation in reticulocytes: application to the pathophysiology of sickle cell dehydration Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease Inhibition of K transport by divalent cations in sickle erythrocytes Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease Compartmentation of sickle cell calcium in endocytic inside-out vesicles Compartmentation of Ca2+ in sickle cells Endocytosis in sickle erythrocytes: A mechanism for elevated intracellular Ca2+ levels Erythrocyte adherence to endothelium in sickle cell anemia: a possible determinant of disease severity Abnormal adherence of sickle cell erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures Rheological studies of erythrocyte-endothelial cell interactions in sickle cell disease Sickle cell vaso-occlusion In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications Adherence of sickle erythrocytes to vascular endothelial cells; requirement for both cell membrane changes and plasma factors Sickle reticulocytes adhere to VCAM-1 a4b1-integrin expression on sickle reticulocytes: vascular cell adhesion molecular-1-dependent binding to endothelium Platelet hyperactivity in sickle cell disease: a consequence of hyposplenism Significance of plasma beta-thromboglobulin values in patients with sickle cell disease Platelet activation during steady state sickle cell disease Phenomenology to function Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vasoocclusion P-selectin mediates the adhesion of sickle erythrocytes to the endothelium Occlusion of large cerebral vessels in sickle cell anemia Sickle cell anemia and central nervous system infarction: a neuropathological study Hypofibronectinaemia and severity of sickle cell anaemia Hypoxia/reoxygenation causes inflammatory response in transgenic sickle mice but not in normal mice Sickle cell anemia as an inflammatory disease Monoclonal antibodies to αvβ3 (7E3and LM609) inhibit sickle red blood cell endothelium interaction induced by platelet activating factor Blockade of adhesion of sickle cells to endothelium by monoclonal antibodies Thalassemia in blacks: genetic and clinical aspects and interactions with the sickle hemoglobin gene The Senegal DNA haplotype is associated with the amelioration of anemia in African-American sickle cell anemia patients Sickle cell anemia bs-gene-cluster haplotypes as prognostic indicators of vital organ failure Rheologic predictors of the severity of the painful sickle cell crisis The painful crisis of homozygous sickle cell disease: a study of risk factors Pain in sickle cell disease: rates and risk factors The prevalence of avascular necrosis in sickle cell anemia: correlation with athalassemia Sickle cell disease as a cause of osteonecrosis of the femoral head Leg ulcers in patients with sickle cell disease Alpha thalassemia and stroke risk in sickle cell anemia Is Hb A2 elevated in adults with sickle-α-thalassemia (Bs/Bs;-α/-α)? keywords: acute; adhesion; anemia; blood; cell; cell anaemia; cell disease; chest; children; disease; effect; gene; hydroxyurea; levels; management; non; opioid; pain; patients; rbc; sickle; sickle hb; syndrome; therapy; transfusion; treatment; use cache: cord-006508-rje9bnph.txt plain text: cord-006508-rje9bnph.txt item: #132 of 2876 id: cord-006517-845w9r6l author: Lalueza, A. title: Impact of severe hematological abnormalities in the outcome of hospitalized patients with influenza virus infection date: 2017-05-13 words: 4071 flesch: 41 summary: Although hematological abnormalities have been described among patients with influenza virus infection, little is known about their impact on the outcome of the patients. This was an observational retrospective study including all adult patients with diagnosis of influenza virus infection hospitalized from January to May 2016 in our institution. keywords: abnormalities; cytopenias; group; infection; influenza; outcome; patients; virus cache: cord-006517-845w9r6l.txt plain text: cord-006517-845w9r6l.txt item: #133 of 2876 id: cord-006518-al94gxjw author: Calder, Philip C. title: n−3 Fatty acids, inflammation, and immunity— Relevance to postsurgical and critically III patients date: 2004 words: 10067 flesch: 25 summary: Fish oil did not decrease bacterial translocation across the gut, and so the authors concluded that fish oil must have improved bacterial killing. Comparison Between Young and Older Women The Effect on Human Tumor Necrosis Factor a and Fatty Acids from Vegetable Oil or Fish Oil Prostaglandin E2 Production and T-Cell Function After Fish-Oil Supplementation: Response to Antioxidant Co-supplementation Effects of Dietary Enrichment with Eicosapentaenoic Acid and Docosahexaenoic Acid on In Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function Dietary ω-3 Polyunsaturated Fatty Acids Inhibit Phosphoinositide Formation and Chemotaxis in Neutrophils n-3 Fatty Acids and Cysteinyl-Leukotriene Formation in Humans in vitro, ex vivo and in vivo Manipulation of Platelet Aggregation by Prostaglandins and Their Fatty Acid Precursors: Pharmacological Basis for a Therapeutic Approach Interaction Between Peroxidase and Cyclooxygenase Activities in Prostaglandin-Endoperoxide Synthase Eicosapentaenoic Acid Inhibits Prostaglandin D2 Generation by Inhibiting Cyclo-oxygenase-2 in Cultured Human Mast Cells Effects of Exogenous Arachidonic, Eicosapentaenoic, and Docosahexaenoic Acids on the Generation of 5-Lipoxygenase Pathway Products by Ionophore-Activated Human Neutrophils Effect of Docosahexaenoic Acid (DHA) on Arachidonic Acid Metabolism and Platelet Function Docosahexaenoic Acid is a Strong Inhibitor of Prostaglandin but Not Leukotriene Biosynthesis N-3 Fatty Acids Specifically Modulate Catabolic Factors Involved in Articular Cartilage Degradation Pathologic Indicators of Degradation and Inflammation in Human Osteoarthritic Cartilage are Abrogated by Exposure to N-3 Fatty Acids Fatty Acid Substrate Specificities of Human Prostaglandin-Endoperoxide H Synthase-1 and -2 Structure of Eicosapentaenoic and Linoleic Acids in the Cyclooxygenase Site of Prostaglandin Endoperoxidase H Synthase-1 Separation and Quantification of PGE3 Following Derivatization with Panacyl Bromide by High Pressure Liquid Chromatography with Fluorometric Detection Human Neutrophil Chemotactic and Degranulating Activities of Leukotriene B5 (LTB5) Derived from Eicosapentaenoic Acid Characterization and Biologic Properties of 5,12-Dihydroxy Derivatives of Eicosapentaenoic Acid, Including Leukotriene-B5 and the Double Lipoxygenase Product Synthesis of 4-Series and 5-Series Leukotrienes in the Lung Microvasculature Challenged with Escherichia coli Hemolysin: Critical Dependence on Exogenous Free Fatty Acid Supply Impact of Arachidonic Acid Versus Eicosapentaenoic Acid on Exotoxin-Induced Lung Vascular Leakage-Relation to 4-Series Versus 5-Series Leukotriene Generation Alteration of n-3 Fatty Acid Composition in Lung Tissue After Short-Term Infusion of Fish Oil Emulsion Attenuates Inflammatory Vascular Reaction Anti-Inflammatory Lipid Signals Generated From Dietary n-3 Fatty Acids via Cyclooxygenase-2 and Transcellular Processing: keywords: acid; cells; chain; effects; expression; fatty; fish; human; n-3; oil; patients; production; response; sepsis; studies; tnf cache: cord-006518-al94gxjw.txt plain text: cord-006518-al94gxjw.txt item: #134 of 2876 id: cord-006523-zxn4oqly author: Lodha, Rakesh title: Nosocomial infections in pediatric intensive care units date: 2001 words: 5228 flesch: 30 summary: The efficacy of infection surveillance and control programs in preventing nosocomial infections in US hospitals Hand washing and hand disinfection Controlling antimicrobial resistance in hospitals: infection control and use of antibiotics Enteral nutrition in the critically ill patient: a critical review of the evidence An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care patients Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma The role of understaffing in central venous catheter-associated bloodstream infections Patient density, nurse-to-patient ratio and nosocomial infection risk in a pediatric cardiac intensive care unit At least one of the following: a. new onset of purulent sputum or change in character of sputum b. organisms cultured from blood c. isolation of an etiologic agent from a specimen obtained by transtracheal aspirate, bronchial brushing, or biopsy. The NNIS data emphasizes that the duration of stay in an ICU is an important determinant of nosocomial infection; therefore, the length of stay should be one of the denominators in calculation of nosocomial infection rates2 In addition, it highlight the importance of invasive devices (endotracheal tubes, intravascular catheters, urinary catheters) in development of nosocomial infections. keywords: bloodstream; care; catheter; children; diagnosis; infections; patients; pneumonia; risk; tract; urine cache: cord-006523-zxn4oqly.txt plain text: cord-006523-zxn4oqly.txt item: #135 of 2876 id: cord-006544-yr4u61qv author: Miesbach, W. title: Recurrent life-threatening thromboembolism and catastrophic antiphospholipid syndrome in a patient despite sufficient oral anticoagulation date: 2004-03-20 words: 3876 flesch: 32 summary: This case report shows that recurrent episodes of thrombosis can occur despite seemingly adequate anticoagulation in patients with CAPS. Retrospective studies suggest that patients with APS have an increased risk of recurrent thromboembolism keywords: antibodies; anticoagulation; antiphospholipid; aps; inr; lupus; patients; recurrent; syndrome; treatment cache: cord-006544-yr4u61qv.txt plain text: cord-006544-yr4u61qv.txt item: #136 of 2876 id: cord-006545-c12m75gq author: Pinilla, Inmaculada title: Radiological prognostic factors in patients with pandemic H1N1 (pH1N1) infection requiring hospital admission date: 2011-05-27 words: 3048 flesch: 42 summary: [10] , although their study was carried out in patients under 20 years of age, and it has been communicated that severe cases among pediatric patients occur predominantly in children with underlying conditions, while adults seem to have severe viral pneumonia and ARDS often in previously healthy subjects [6] . This pattern, which is rare on other series of adult patients with pH1N1 infection, may be explained by the inclusion of very young patients, between 14 and 20 years in our cohort. keywords: admission; chest; h1n1; icu; influenza; patients cache: cord-006545-c12m75gq.txt plain text: cord-006545-c12m75gq.txt item: #137 of 2876 id: cord-006563-qmigctkp author: None title: The abstracts of the 26th congress of ESCTAIC, Timisoara, Romania, September 22–24 2016 date: 2017-03-07 words: 8635 flesch: 41 summary: The increase in lung volumes has been demonstrated by impedance plethysmography in post-cardiac surgical patients (Corley et al., 2011) . Current studies contain data with relatively small groups of patients. keywords: anesthesia; anesthesiologist; block; care; data; device; effects; emergency; group; incident; information; management; nerve; operating; pain; patients; simulation; study; surgery; system; time; use cache: cord-006563-qmigctkp.txt plain text: cord-006563-qmigctkp.txt item: #138 of 2876 id: cord-006595-brpngt14 author: Pecchi, A. title: Radiologic imaging of the transplanted bowel date: 2005-03-04 words: 6161 flesch: 34 summary: Traditional contrast examination of the gastrointestinal tract continues to play an important role in transplanted patients because it is a simple examination that allows evaluation of the graft anatomy and recovery of motility of the residual native bowel and the transplanted loops. US represents a quick examination technique that is easily available and well tolerated by patients, and it has a role to play in the follow-up of transplanted patients and in the identification of major postoperative complications. keywords: bowel; contrast; evaluation; examination; loops; patients; study; transit; wall cache: cord-006595-brpngt14.txt plain text: cord-006595-brpngt14.txt item: #139 of 2876 id: cord-006621-0fxpn7qf author: Cantwell, Tamara title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date: 2017-10-10 words: 2508 flesch: 34 summary: Patient evolved with severe respiratory failure, associated with hemoptysis, and rapidly severe hemodynamic compromise. Patient evolved with severe respiratory failure, associated with hemoptysis, and rapidly severe hemodynamic compromise. keywords: acute; ecmo; failure; leptospirosis; membrane; oxygenation; patient cache: cord-006621-0fxpn7qf.txt plain text: cord-006621-0fxpn7qf.txt item: #140 of 2876 id: cord-006679-nhbofufv author: Lucarelli, G. title: Bone marrow transplantation for thalassemia date: 1993 words: 2005 flesch: 45 summary: Patients for whom all three criteria were adverse constituted class 3, patients with none of the adverse criteria constituted class one and patients with one or various association of the adverse criteria formed Class 2. key: cord-006679-nhbofufv authors: Lucarelli, G.; Angelucci, E.; Giardini, C.; Baronciani, D.; Galimberti, M.; Polchi, P.; Erer, B. title: Bone marrow transplantation for thalassemia date: 1993 journal: Indian J Pediatr DOI: 10.1007/bf02751428 sha: doc_id: 6679 cord_uid: nhbofufv Early trials of allogeneic bone marrow transplantation (BMT) for homozygous beta-thalassemia and the analyses of results of transplantation in patients less then 16 years old have allowed us to identify three classes of risk using the criteria of degree of hepatomegaly, the degree of portal fibrosis and the quality of the chelation treatment given before the transplant. keywords: class; patients; survival; thalassemia; transplant cache: cord-006679-nhbofufv.txt plain text: cord-006679-nhbofufv.txt item: #141 of 2876 id: cord-006701-q8qh1kas author: Sadeghi, Behnam title: Treatment of radiculomyelopathy in two patients with placenta-derived decidua stromal cells date: 2019-12-18 words: 2348 flesch: 54 summary: Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells Therapy with stem cells in inflammatory bowel disease Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy Treatment of acute respiratory distress syndrome with allogeneic adiposederived mesenchymal stem cells: a randomized, placebo-controlled pilot study Treatment of severe chronic graft-versus-host disease with decidual stromal cells and tracing with (111)indium radiolabeling Fetal membrane cells for treatment of steroid-refractory acute graft-versus-host disease Successful reversal of acute lung injury using placenta-derived decidual stromal cells Placenta-derived decidua stromal cells for treatment of severe acute graft-versus-host disease Mother's little helpers: mechanisms of maternal-fetal tolerance Stromal cells from term fetal membrane are highly suppressive in allogeneic settings in vitro Placenta-derived decidua stromal cells for hemorrhagic cystitis after stem cell transplantation Decidual stromal cells promote regulatory T cells and suppress alloreactivity in a cell contact-dependent manner Immunogenicity of decidual stromal cells in an epidermolysis bullosa patient and in allogeneic hematopoietic stem cell transplantation patients Immune-mediated myelopathy following allogeneic stem cell transplantation Immune-mediated myelopathy after allogeneic marrow transplantation Acknowledgements We thank Gunilla Tillinger for preparation of this manuscript. After cell infusion, she was able to stand on one leg, sensation in the belly normalized, and she was discharged. keywords: arms; cells; dscs; patient; stem; stromal cache: cord-006701-q8qh1kas.txt plain text: cord-006701-q8qh1kas.txt item: #142 of 2876 id: cord-006702-ekf6mja9 author: None title: Abstracts for the 17th IPNA Congress, Iguaçu, Brazil, September 2016: Oral Presentations date: 2016-08-17 words: 23283 flesch: 45 summary: Conclusions: CKD patients have modifiable risk factors for intimal and medial vascular disease which were not detected by CUS. Among the transplant patients, the percent of patients achieving seropositivity was significantly lower at blood draw 2 for HPV genotypes 6 (63.6%, p=0.003), 11 (63.6%, p=0.003) and 18 (72.7%, p=0.02) and blood draw 3 for HPV genotypes 6 (62.5%, p=0.02), 11 (50%, p=0.001), 16 (75%, p=0.04), and 18 (50%, p=0.001). & Whiskers represent the 25th or 75th percentiles + (1.5x Interquartile Range) Antibody levels in transplant patients compared to CKD patients and to dialysis patients for HPV genotypes 6, 11, 16, 18 . keywords: age; analysis; associated; blood; cell; children; chronic; ckd; cohort; conclusions; data; days; dialysis; disease; dose; fgf23; follow; group; growth; kidney; levels; mean; median; methods; model; months; mutations; objectives; patients; pediatric; pts; renal; results; risk; stage; study; syndrome; therapy; time; transplant; treatment; university; urine; vur; years cache: cord-006702-ekf6mja9.txt plain text: cord-006702-ekf6mja9.txt item: #143 of 2876 id: cord-006714-q7wy76e2 author: Delannoy, P.-Y. title: Impact of combination therapy with aminoglycosides on the outcome of ICU-acquired bacteraemias date: 2012-02-15 words: 2881 flesch: 41 summary: ICU patients with or without bacteraemia have an increased volume of distribution. Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a meta-analysis of randomized, controlled trials Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? keywords: bacteraemia; beta; combination; icu; patients; therapy cache: cord-006714-q7wy76e2.txt plain text: cord-006714-q7wy76e2.txt item: #144 of 2876 id: cord-006750-cg2i2bae author: Stoots, Sarah Abramson title: Clinical Insights into Diffuse Alveolar Hemorrhage in Antiphospholipid Syndrome date: 2019-09-06 words: 5226 flesch: 26 summary: Clinical presentation, histology, survival, and outcome Possible primary antiphospholipid syndrome with concurrent diffuse alveolar hemorrhaging and Libman-sacks endocarditis mimicking catastrophic antiphospholipid syndrome Rituximab induces resolution of recurrent diffuse alveolar hemorrhage in a patient with primary antiphospholipid antibody syndrome Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors in a series of 250 patients A 32-year-old man with hypoxemia and bilateral upper-lobe predominant ground-glass infiltrates on chest imaging McMaster RARE-Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome Primary antiphospholipid syndrome associated with diffuse alveolar hemorrhage and pulmonary thromboembolism The challenge of bleeding in antiphospholipid antibody-positive patients Hydroxychloroquine reverses thrombogenic properties of antiphospholipid antibodies in mice Global effects of fluvastatin on the prothrombotic status of patients with antiphospholipid syndrome Effect of antimalarials on thrombosis and survival in patients with systemic lupus erythematosus Antithrombotic effects of hydroxychloroquine in primary antiphospholipid syndrome patients Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Pulmonary capillaritis is particularly associated with autoimmune or inflammatory diseases; in a review of 34 lung biopsies of diffuse pulmonary hemorrhage patients (vasculitis-and connective disease-associated DAH in 14 and four cases, respectively), capillaritis was present in 88% of the specimens; however, none of these patients had APS keywords: alveolar; antiphospholipid; aps; dah; diffuse; hemorrhage; patients; pulmonary; remission; syndrome; treatment cache: cord-006750-cg2i2bae.txt plain text: cord-006750-cg2i2bae.txt item: #145 of 2876 id: cord-006768-r2pa9qw0 author: Shobha, Vineeta title: Granulomatosis with polyangiitis: clinical course and outcome of 60 patients from a single center in South India date: 2018-02-28 words: 3089 flesch: 50 summary: Patients who fulfilled any two of the four criteria proposed by the American College of Rheumatology, and those with clinical features of GPA with ANCA positivity and histopathological confirmation, were included in the study. Out of 60 patients, initial BVAS evaluation showed that 57 (95%) patients had severe disease and 3 (5%) keywords: disease; gpa; granulomatosis; involvement; patients; treatment; vasculitis cache: cord-006768-r2pa9qw0.txt plain text: cord-006768-r2pa9qw0.txt item: #146 of 2876 id: cord-006828-i88on326 author: None title: Abstracts DGRh-Kongress 2013 date: 2013-09-15 words: 30854 flesch: 47 summary: Es zeigen sich keine signifikanten Unterschiede in der Krankheitsaktivität der beiden Gruppen (vor Einleitung der ADA-Therapie nach DMARD-und nach anti-TNF-Versagen). key: cord-006828-i88on326 authors: nan title: Abstracts DGRh-Kongress 2013 date: 2013-09-15 journal: Z Rheumatol DOI: 10.1007/s00393-013-1255-1 sha: doc_id: 6828 cord_uid: i88on326 nan im Namen der DGRh, der DGORh und der GKJR begrüßen wir Sie ganz herzlich zu unserem diesjährigen Kongress Visualisierung therapeutischer Effekte von Vasodilatantien beim sekundären Raynaud-Syndrom mittels fluoreszenzoptischer Bildgebung DI.14 Stellenwert der Gelenksonographie bezüglich Diagnose, Behandlung und Therapiekontrolle der Bursitis intermetatarsalis -einer häufig übersehenen Differenzialdiagnose. keywords: abatacept; active; activity; adiponectin; als; analysis; anti; antibodies; arthritis; auch; auf; b cells; background; baseline; bei; bei der; blood; bone; cd4; cells; changes; conclusion; das; das28; data; days; den; der; des; die; disease; dose; effects; eine; elisa; expression; für; human; hypoxia; ifn; igg; il-6; immune; inflammation; ist; joint; levels; lupus; marrow; methods; mice; mit; monocytes; months; mri; mtx; nach; new; non; patienten; patients; plasma; plasma cells; positive; production; progression; ra patients; receptor; remission; response; results; rheumatoid; role; serum; sich; sle; sle patients; sowie; stimulation; study; synovial; t cells; therapie; therapy; time; tnf; treatment; und; von; week; werden; wurde; years; zur cache: cord-006828-i88on326.txt plain text: cord-006828-i88on326.txt item: #147 of 2876 id: cord-006841-3u56erru author: Einsele, Hermann title: Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date: 2003-09-10 words: 5276 flesch: 30 summary: key: cord-006841-3u56erru authors: Einsele, Hermann; Bertz, Hartmut; Beyer, Jörg; Kiehl, Michael G.; Runde, Volker; Kolb, Hans-Jochen; Holler, Ernst; Beck, Robert; Schwerdfeger, Rainer; Schumacher, Ulrike; Hebart, Holger; Martin, Hans; Kienast, Joachim; Ullmann, Andrew J.; Maschmeyer, Georg; Krüger, William; Niederwieser, Dietger; Link, Hartmut; Schmidt, Christian A.; Oettle, Helmut; Klingebiel, Thomas title: Infectious complications after allogeneic stem cell transplantation: epidemiology and interventional therapy strategies: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) date: 2003-09-10 journal: The risk of infection after allogeneic stem cell transplantation is determined by the underlying disease, the intensity of previous treatments and complications that may have occurred during that time, but above all, the risk of infection is determined by the selected transplantation modality (e.g. HLA-match between the stem cell donor and recipient, T cell depletion of the graft, and others). keywords: cell; cmv; day; fever; incidence; infections; patients; risk; stem; transplantation; treatment cache: cord-006841-3u56erru.txt plain text: cord-006841-3u56erru.txt item: #148 of 2876 id: cord-006849-vgjz74ts author: None title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 words: 222539 flesch: 45 summary: Day after surgery patient was asymptomatic, got full oral diet. Methods: From January 2001 to March 2005 all characteristics of surgical patients with diverticular and colon adenocarcinoma colovesical fistulae were reviewed. keywords: abdominal; acute; age; aim; aims; analysis; anastomosis; anatomy; anterior; approach; artery; associated; average; background; bile; biliary; bleeding; blood; bmi; body; bowel; bypass; cancer patients; cancer surgery; cases; cholecystectomy; chronic; clinical; closure; colon; complete; complications; conclusion; control; conventional; conversion; course; data; days; defect; diagnosis; differences; disease; dissection; distal; drainage; duct; emergency surgery; endoscopic; esophageal; esophagus; evaluation; examination; experience; factors; female; fluorescence; follow; following; gastrectomy; gastric; general; good; grade; group; hepatic; hernia; history; hospital; icg; imaging; incision; intervention; intraoperative; introduction; laparoscopic; leak; learning; left; lesion; level; line; liver; loss; lymph; management; mass; mean; median; medical; mesh; methods; model; months; morbidity; mortality; need; new; node; non; normal; number; objective; open; operation; operation time; order; outcomes; p =; pain; patients; perform; period; port; position; postoperative; preoperative; present; primary; procedure; quality; rate; recurrence; reflux; repair; report; resection; results; right; risk; risk patients; robotic; safety; scan; score; short; size; sleeve; space; stage; standard; stay; step; stomach; studies; study; study group; surgeons; surgery; surgery group; surgery patients; surgical; survival; suture; symptoms; system; technique; term; time; tissue; total; training; treatment; tumor; type; use; video; wall; weight; years cache: cord-006849-vgjz74ts.txt plain text: cord-006849-vgjz74ts.txt item: #149 of 2876 id: cord-006854-o2e5na78 author: None title: Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date: 2018-04-20 words: 166333 flesch: 44 summary: Here we were able to demonstrate that the procedure can be safely used in laparoscopic surgery patients. On bivariate analysis, robotic-assist patients had a higher rate of readmission than laparoscopic patients (7.5% vs. 6.4%; P=.03), but no differences in 30-day reoperation ( Conclusion: Robotic-assistance does not confer an increased rate of morbidity and mortality after RYGB, and represents a feasible surgical modality for the surgeon willing to adopt the technology and accept its limitations. keywords: acute; age; aim; analysis; anastomosis; approach; assessment; assisted; average; background; bile; biliary; bleeding; blood; bmi; bowel; bypass; cancer; cancer patients; cancer surgery; care; cases; center; cholecystectomy; clinical; colon; colorectal; complications; conclusion; control; conversion; data; days; diagnosis; difference; disease; dissection; endoscopic; esophageal; evaluation; experience; factors; female; follow; following; gallbladder; gastrectomy; gastric; general; gerd; group; hernia; hernia repair; hiatal; history; hospital; icg; imaging; incidence; incision; index; injury; institution; introduction; laparoscopic; leak; left; length; level; literature; liver; loss; lsg; lymph; management; mass; mean; median; medical; mesh; methods; minutes; months; morbidity; mortality; non; number; obesity; objective; obstruction; operation; operative; outcomes; pain; pancreatic; patients; performance; period; placement; postoperative; preoperative; present; primary; prior; procedure; quality; range; rate; recurrence; repair; report; resection; residents; results; retrospective; review; right; risk; robotic; rygb; safety; score; series; site; skills; sleeve; stage; standard; stay; stomach; studies; study; surgeons; surgery; surgery patients; surgical; symptoms; system; technique; term; test; time; tissue; total; training; treatment; tumor; type; university; use; wall; weight; years cache: cord-006854-o2e5na78.txt plain text: cord-006854-o2e5na78.txt item: #150 of 2876 id: cord-006856-b1w25ob5 author: None title: 19th Meeting of the Austrian Society of Transplantation, Transfusion, and Genetics, October 26–28, 2005 date: 2005 words: 29728 flesch: 49 summary: The average serum creatinine after 5 years is 153.56 ± 24.65 µmol/l. Cumulative graft survival after 5 years is shown by Kaplan-Meier curve: graft survival, 75.1%; patients survival, 83.9%; graft and patients survival, 67.1%. Extracorporeal photopheresis has been shown to be beneficial in acute and chronic rejection in heart transplant patients and has also been used in lung transplant recipients with acute rejection or bronchiolitis obliterans. Methods. keywords: acute; age; allogeneic; anti; background; blood; cardiac; cells; chronic; cmv; conclusions; data; day; days; der; die; disease; donor; eine; follow; function; graft; group; heart; immunosuppression; induction; infection; kidney; levels; liver; lung; male; median; methods; mice; mit; months; n =; organ; outcome; patients; positive; post; rate; recipients; rejection; reperfusion; results; risk; serum; study; survival; term; therapy; time; total; transplantation; transplanted; treatment; von; years cache: cord-006856-b1w25ob5.txt plain text: cord-006856-b1w25ob5.txt item: #151 of 2876 id: cord-006860-a3b8hyyr author: None title: 40th Annual Meeting of the GTH (Gesellschaft für Thrombose- und Hämostaseforschung) date: 1996 words: 90772 flesch: 46 summary: The data show that children with low risk did in part receive higher doses of heparin and/or AT III concentrate than did high risk patients, whereas plasma therapy was adjusted to severity of eoagnlopathy. Inhibitor testing was done on patients plasma samples using the Bethesda method. keywords: activation; activity; acute; addition; age; agents; aggregation; analysis; antibodies; anticoagulant; anticoagulation; antigen; antithrombin; apc; aptt; assay; binding; bleeding; blood; blood coagulation; blood samples; cases; cells; children; clinical; clotting; coagulation; coagulation factor; complex; complications; concentrations; conclusion; contrast; control; coronary; correlation; count; data; day; days; deficiency; diagnosis; disease; dose; effect; elevated; endothelial; events; expression; factor; factor v; factor viii; family; fibrin; fibrinogen; formation; group; heparin; hirudin; hours; human; incidence; increase; influence; infusion; inhibitor; inr; laboratory; levels; low; mean; median; method; months; mutation; normal; order; parameters; patients; period; phase; plasma; plasma samples; plasminogen; platelet; platelet activation; platelet factor; present; products; protein; protein c; prothrombin; pts; range; reagent; receptor; reduced; release; resistance; response; results; risk; risk factor; role; samples; specific; studies; study; surface; surgery; system; test; therapy; thrombin; thrombosis; time; tissue; total; treatment; type; use; values; vascular; vein; venous; viii; vwf; weight; years cache: cord-006860-a3b8hyyr.txt plain text: cord-006860-a3b8hyyr.txt item: #152 of 2876 id: cord-006862-5va1yyit author: None title: ITS ASM 2012 date: 2012-11-04 words: 26008 flesch: 50 summary: A questionnaire was sent to relevant members of the Exercise has been shown to improve quality of life in respiratory patients. Conclusion: A significant percentage of respiratory patients lack adequate knowledge of their respiratory medication; this is despite a majority having previously been educated on this medication. keywords: aat; aatd; age; analysis; asthma; cancer; cases; chest; clinic; copd; copd patients; data; diagnosis; disease; group; history; hospital; inhaler; ipf; levels; lung; lung disease; male; mean; months; n =; negative; non; osas; p =; patients; pulmonary; respiratory; results; sarcoidosis; score; smoking; study; therapy; treatment; years cache: cord-006862-5va1yyit.txt plain text: cord-006862-5va1yyit.txt item: #153 of 2876 id: cord-006864-t5qsjyfi author: Norris, S. title: National scientific medical meeting 1995 abstracts: Oral presentations date: 1995 words: 36498 flesch: 51 summary: X 100 birth weight (g) or birth head circumference (cm) divided by the age in weeks and expressed as % per weekhead index (HI) and weight index (WI). Home interviews suggest 31.1% Suicidal Ideation ever, 2.7% Self-harm rate -4% of those interviewed felt suicide was a right under adverse circumstances. keywords: a. a.; a. g.; a. j.; activity; age; analysis; blood; c. a.; c. j.; c. m.; c. t.; cases; cells; control; d. a.; d. c.; d. d.; d. j.; d. p.; data; disease; evidence; expression; fitzgerald; g. d.; g. j.; g. m.; group; hospital; increase; infection; j. f.; j. j.; j. s.; k. d.; levels; m. a.; m. j.; mean; non; p. a.; p. j.; p. p.; patients; period; pregnancy; prevalence; range; rate; results; risk; samples; study; subjects; therapy; time; treatment; v. j.; years cache: cord-006864-t5qsjyfi.txt plain text: cord-006864-t5qsjyfi.txt item: #154 of 2876 id: cord-006869-g2q1gpp0 author: None title: Neurocritical Care Society 7th Annual Meeting date: 2009-10-08 words: 45443 flesch: 47 summary: In an IRB approved, prospective, open-label single-blinded Phase I study, SAH patients with elevated transcranial Doppler (TCD) velocities and Lindegaard Indices suggesting cVSP were enrolled. SAH patients were prospectively entered into an institutional database; those with myopathy were retrospectively identified. keywords: acute; admission; analysis; aneurysm; blood; brain; care; cases; cerebral; control; data; days; death; diagnosis; eeg; glucose; grade; group; hemorrhage; hospital; hours; hypothermia; ich; icp; icu; injury; intracranial; levels; mean; median; medical; monitoring; mortality; neurocritical; non; outcome; patients; pressure; risk; sah; sah patients; scale; score; serum; status; stroke; studies; study; subarachnoid; tbi; temperature; therapy; time; treatment; use; vasospasm; vs.; years cache: cord-006869-g2q1gpp0.txt plain text: cord-006869-g2q1gpp0.txt item: #155 of 2876 id: cord-006870-f5w6fw6q author: None title: Abstracts Presented at the Neurocritical Care Society (NCS) 15th Annual Meeting date: 2017-09-19 words: 122395 flesch: 46 summary: The best model fit was for good outcome (modified Rankin Score 0-2 equivalents) based on % patients with WFNS 4-5 and age (R2=0.54; p<0.001). Decreasing time spent in cervical spinal immobilization could improve patient care by allowing greater access to / range-of-motion of the neck, increasing patient comfort, and decreasing skin breakdown. keywords: acute; administration; admission; adult patients; analysis; arrest; asah; associated; baseline; blood; brain; brain injury; cardiac; care patients; care unit; case; center; cerebral; cohort; common; complications; data; days; death; diagnosis; difference; discharge; duration; early; edema; eeg; effect; epilepticus; evd; factors; findings; following; gcs; group; head; hematoma; hemorrhage; hemorrhage patients; hospital; hours; ich; ich patients; icp; icu; identified; imaging; improvement; infusion; initial; injury; intracerebral; intracranial; ischemic; left; level; los; management; mean; median; medical; minutes; model; monitoring; months; mortality; mri; neurocritical; new; non; number; outcome; patients; period; placement; population; post; presence; present; pressure; primary; prior; prospective; rate; refractory; related; report; results; review; right; risk; risk patients; sah patients; scale; score; secondary; seizures; srse; status; stay; stroke patients; studies; study; subarachnoid; surgery; tbi; tbi patients; test; therapy; time; total; treatment; unit; use; years cache: cord-006870-f5w6fw6q.txt plain text: cord-006870-f5w6fw6q.txt item: #156 of 2876 id: cord-006876-v2m5l5wz author: None title: Neurocritical Care Society 14(th) Annual Meeting date: 2016-08-11 words: 59827 flesch: 46 summary: However, the trend was not uniform -48% patients had no correlation between rSO2 and CPP, 29% showed a positive correlation and 23% showed a negative correlation. Major reasons for satisfaction included: physician response to emergencies, physician -nurse communication, and patient outcome. keywords: acute; admission; analysis; arrest; asah; associated; baseline; blood; brain; brain injury; cardiac; care; care patients; care unit; case; center; cerebral; cohort; complications; data; days; death; developed; discharge; dose; duration; eeg; following; gcs; group; hemorrhage; hospital; hours; ich; ich patients; icp; icu; impact; injury; intensive; intracranial; management; mean; median; medical; model; monitoring; months; mortality; neurocritical; neurological; new; non; onset; outcome; patients; pcc; post; pressure; primary; rate; results; review; sah; sah patients; score; seizures; status; studies; study; subarachnoid; tbi; therapy; time; total; treated; treatment; unit; use; years cache: cord-006876-v2m5l5wz.txt plain text: cord-006876-v2m5l5wz.txt item: #157 of 2876 id: cord-006880-9dgmdtj8 author: None title: Neurocritical Care Society 10th Annual Meeting: October 4 - 7, 2012 Sheraton Denver Downtown Hotel Denver, Colorado date: 2012-09-19 words: 82474 flesch: 47 summary: Included patients were 55.5 ±15.2 years old with female preponderance (65.5%, (76/116)). Admission NIHSS was 11 for ICU patients and 9 for SU patients (NS). keywords: acute; admission; adult patients; analysis; aneurysm; arrest; arrest patients; asah; blood; brain; brain injury; cardiac; care; case; center; cerebral; cohort; coma; complications; data; days; dci; death; diagnosis; discharge; early; factors; following; gcs; good; group; head; hemorrhage; high; hospital; hours; hypothermia; ich; icp; icu; icu patients; imaging; increase; initial; injury; intracranial; ischemic; levels; management; mean; median; medical; monitoring; mortality; mri; mrs; neurocritical; non; onset; outcome; patients; poor; post; present; pressure; rate; regression; results; review; risk; sah; sah patients; scale; score; status; stroke patients; studies; study; subarachnoid; surgical; tbi; tbi patients; therapeutic; therapy; time; total; traumatic; treatment; unit; use; vasospasm; vs.; years cache: cord-006880-9dgmdtj8.txt plain text: cord-006880-9dgmdtj8.txt item: #158 of 2876 id: cord-006882-t9w1cdr4 author: None title: Royal Academy of Medicine in Ireland date: 2012-07-22 words: 13737 flesch: 50 summary: Older patients have lower lean muscle mass and therefore using serum creatinine alone as marker of renal function can lead to underdiagnosis of CKD. Due of the favourable prognosis with this type of tumour, MTSCC must be differentiated from papillary renal cell carcinoma to avoid administration of excessive adjuvant treatment to patients. keywords: audit; bone; case; complications; data; day; diabetes; disease; guidelines; hospital; management; patients; period; practice; prescribing; prevalence; results; study; surgery; therapy; time; treatment; use; women; year cache: cord-006882-t9w1cdr4.txt plain text: cord-006882-t9w1cdr4.txt item: #159 of 2876 id: cord-006888-qfnukav4 author: None title: Irish Thoracic Society Annual Scientific Meeting, Ramada Hotel, Belfast: 7th–8th November 2008 date: 2008-10-21 words: 30386 flesch: 51 summary: We determined the frequency of HSV-1 in COPD patients (stable and exacerbated) and if it was associated with disease severity and mortality. Methods: Stable and exacerbated COPD patients were recruited. keywords: activity; age; aim; analysis; associated; asthma; cancer; care; cells; children; copd; copd patients; data; diagnosis; disease; effect; exercise; female; fev1; function; group; guidelines; hospital; levels; lung; male; management; mean; n =; non; p =; patients; population; pulmonary; range; respiratory; results; service; sleep; smoking; study; therapy; time; treatment; years cache: cord-006888-qfnukav4.txt plain text: cord-006888-qfnukav4.txt item: #160 of 2876 id: cord-006924-1i3kf01j author: None title: Abstracts from USCAP 2020: Pulmonary, Mediastinum, Pleura, and Peritoneum Pathology (1869-1980) date: 2020-03-05 words: 25402 flesch: 47 summary: We reviewed lung cases with eosinophilic deposits and immune infiltrates with negative Congo Red stain. Background: Molecular targeted therapies against EGFR and ALK have improved the quality of life of lung adenocarcinoma patients. keywords: adenocarcinoma; analysis; background; cancer; cases; cell; conclusions; design; diagnosis; disease; egfr; expression; features; high; ihc; l1 expression; lung; mutations; ngs; non; nsclc; patients; primary; results; specimens; staining; study; survival; tissue; tumor; type cache: cord-006924-1i3kf01j.txt plain text: cord-006924-1i3kf01j.txt item: #161 of 2876 id: cord-006975-u5ecibta author: Haviland, Kelly title: Outcomes after long-term mechanical ventilation of cancer patients date: 2020-03-30 words: 3622 flesch: 46 summary: Again, the 1-year overall survival for weaned patients in our study was similar to survival rates in previous reports including non-cancer patients. We sought to determine the probability of weaning and overall survival of cancer patients requiring long-term mechanical ventilation in a specialized weaning unit. keywords: care; days; patients; survival; ventilation; weaning cache: cord-006975-u5ecibta.txt plain text: cord-006975-u5ecibta.txt item: #162 of 2876 id: cord-007009-4wbvdg1r author: Takahashi, Toru title: The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan date: 2014-03-15 words: 4691 flesch: 44 summary: SFTSV RNA was present, with high copy numbers, in the right axillary and cervical lymph node sections (Supplementary Table 3 ). Consistent with immunohistochemical analysis results, low copy numbers (100-1000 copies) of SFTSV RNA were also detected in the bone marrow, the spleen, the liver, and the adrenal glands. keywords: cells; fever; figure; japan; lymph; nodes; patients; rna; serum; sftsv; syndrome; thrombocytopenia; virus cache: cord-007009-4wbvdg1r.txt plain text: cord-007009-4wbvdg1r.txt item: #163 of 2876 id: cord-007321-7gi6xrci author: Chow, Anthony W. title: Evaluation of New Anti-Infective Drugs for the Treatment of Respiratory Tract Infections date: 1992-11-17 words: 16092 flesch: 29 summary: In phase 2 and 3 trials, study patients should be stratified according to major host factors (e.g., history and duration of smoking). Clinical studies should include patients of different age groups, since the clinical manifestations of group A streptococcal pharyngitis and tonsillitis may vary with age of the patient. keywords: acute; aom; children; chronic; control; culture; days; diagnosis; drug; evaluation; failure; group; infection; microbiologic; pathogens; patients; pharyngitis; pneumonia; response; sinusitis; sputum; studies; study; symptoms; therapy; treatment cache: cord-007321-7gi6xrci.txt plain text: cord-007321-7gi6xrci.txt item: #164 of 2876 id: cord-007444-c9vu8ako author: Sherk, Peter A. title: The Chronic Obstructive Pulmonary Disease Exacerbation date: 2000-12-01 words: 9175 flesch: 34 summary: They analyzed 362 admissions for acute COPD exacerbation from the APACHE I11 database. This airflow obstruction is generally progressive, may be accompanied by airway hyperreactivity, and often is partially re~ersible.~ Declining lung function is almost universally caused by decades of tobacco smoke exposure and develops insidiously so that patients often do not complain of exertional dyspnea until their 1-second forced expiratory volume (FEV,) is between 40% and 59% of its predicted value.20 When the FEV, falls below 1 L, patients are disabled in the activities of daily living and have a 5-year survival of approximately 50?!0. keywords: acute; aecopd; chronic; copd; disease; exacerbations; failure; infection; mortality; nppv; patients; pulmonary; respiratory; studies; study; therapy; treatment cache: cord-007444-c9vu8ako.txt plain text: cord-007444-c9vu8ako.txt item: #165 of 2876 id: cord-007563-33jxxp1b author: None title: Full Issue PDF date: 2018-06-25 words: 8305 flesch: 37 summary: Patients with paradoxical AS showed a degree of fibrosis similar to that of patients with classical AS or ASrEF ( Figure 1 ). Patients were grouped into classical high-gradient, normal-flow AS with preserved ejection fraction (EF); paradoxical low-flow, low-gradient AS with preserved EF; and AS with reduced EF. keywords: aortic; fibrosis; figure; gch1; heart; isoform; levels; mdx; mice; mir-24; myocytes; patients; phe; study; titin; treatment; use cache: cord-007563-33jxxp1b.txt plain text: cord-007563-33jxxp1b.txt item: #166 of 2876 id: cord-007564-ljqrxjvv author: Leroy, O. title: 04 – Apport des explorations microbiologiques au diagnostic des infections des voies respiratoires basses date: 2006-11-13 words: 13544 flesch: 44 summary: Le rôle de la quantification bactérienne dans la prise en compte du résultat de la culture doit être également discuté. [17] , portant sur 209 patients, retrouve une augmentation de la fréquence de positivité de l'hémoculture avec celle du risque de décès apprécié par la classe de risque établie selon le PSI initial. keywords: bien; cas; ces; cette; chez; comme; community; culture; d'une; dans; des; detection; deux; diagnostic; données; est; infections; les; microbiologiques; même; ont; pac; par; pas; patients; pcr; peut; plus; pneumonia; pour; que; résultats; selon; sensibilité; sont; spécificité; sur; technique; test; toutefois; traitement; une; virus; étiologique; été; être cache: cord-007564-ljqrxjvv.txt plain text: cord-007564-ljqrxjvv.txt item: #167 of 2876 id: cord-007567-vst954ef author: Farquharson, Carolyn title: Responding to the severe acute respiratory syndrome (SARS) outbreak: Lessons learned in a Toronto emergency department() date: 2003-06-04 words: 4232 flesch: 55 summary: Filtered rebreather masks delivering 80% oxygen have been introduced for SARS patients who require high flow oxygen. All waste material from potential SARS patients is placed in a yellow biohazard bag, tied to seal, and then placed in cardboard boxes labeled medical waste. keywords: care; department; emergency; illness; isolation; outbreak; patients; sars; staff cache: cord-007567-vst954ef.txt plain text: cord-007567-vst954ef.txt item: #168 of 2876 id: cord-007575-5ekgabx5 author: Luby, James P. title: Southwestern Internal Medicine Conference: Pneumonias in Adults Due to Mycoplasma, Chlamydiae, and Viruses date: 2016-01-14 words: 12010 flesch: 36 summary: Clinically, the patient with influenza virus pneumonia has the sudden onset off ever, prostration, and myalgias followed shortly by dyspnea. Influenza virus pneumonia occurred during hospitalization. keywords: adults; cases; cmv; diffuse; disease; evidence; infection; infiltrates; influenza; lung; mycoplasma; patients; pneumonia; suprainfection; therapy; tract; varicella; virus; viruses cache: cord-007575-5ekgabx5.txt plain text: cord-007575-5ekgabx5.txt item: #169 of 2876 id: cord-007577-f1jzbtjj author: Raphael Shulman, N. title: Hepatitis-associated antigen date: 2006-09-18 words: 13827 flesch: 38 summary: Giles [34] demonstrated the regular appearance of HAA-positive hepatitis in recipients of HAA positive serum obtained from a patientduringthe acute phase of long-incubation hepatitis. HAA particles aggregated by antibody can be pelleted in ten minutes at 25,000 g and are readily seen after negative staining ( Figure 1 ). keywords: antibody; antigen; australia; blood; chronic; complement; disease; fixation; haa; hepatitis; incubation; liver; particles; patients; serum; tests; virus cache: cord-007577-f1jzbtjj.txt plain text: cord-007577-f1jzbtjj.txt item: #170 of 2876 id: cord-007580-qwh8ei60 author: Knopf, Harry L.S. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 words: 5107 flesch: 49 summary: A comparison of the percent corneal involvement with fold-rise in antibody titer among patients infected with Group 1 (AV 1) and 2 (AV 2) adenoviruses. key: cord-007580-qwh8ei60 authors: Knopf, Harry L.S.; Hierholzer, John C. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 journal: Am J Ophthalmol DOI: 10.1016/0002-9394(75)90398-0 sha: doc_id: 7580 cord_uid: qwh8ei60 nan Ocular viral infections manifest them selves in a variety of clinical pictures. keywords: adenovirus; antibody; corneal; epidemic; group; infections; keratoconjunctivitis; patients; serologic; titer; type cache: cord-007580-qwh8ei60.txt plain text: cord-007580-qwh8ei60.txt item: #171 of 2876 id: cord-007696-83v9yfa6 author: Zisman, David A. title: Pulmonary Fibrosis date: 2005 words: 14011 flesch: 32 summary: An analysis of multiple-cause mortality data Rising mortality from cryptogenic fibrosing alveolitis Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis Diabetes mellitus may increase risk for idiopathic pulmonary fibrosis Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality Clinical significance of histological classification of idiopathic interstitial pneumonia Survival in patients with cryptogenic fibrosing alveolitis: a population-based cohort study The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis Determinants of survival in idiopathic pulmonary fibrosis Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis The role of gastroesophageal reflux in idiopathic pulmonary fibrosis Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis: a case-control study Occupational and environmental risk factors for idiopathic pulmonary fibrosis: a multicenter casecontrol study. Collaborating Centers Cryptogenic fibrosing alveolitis and Epstein-Barr virus: an association? Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis Idiopathic pulmonary fibrosis and hepatitis C virus infection Incidence of hepatitis C virus infection in Italian patients with idiopathic pulmonary fibrosis Idiopathic pulmonary fibrosis and high prevalence of serum antibodies to hepatitis C virus Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction Usual interstitial pneumonia following Texas A2 influenza infection Clinical course, management, and long-term sequelae of respiratory failure due to influenza viral pneumonia Studies on influenza in the pandemic of 1957-1958. keywords: alveolitis; diagnosis; disease; effects; expression; factor; fibrosing; fibrosis; function; ifn; ipf; lung; nsip; patients; pneumonia; pulmonary; studies; study; survival; therapy; treatment; uip cache: cord-007696-83v9yfa6.txt plain text: cord-007696-83v9yfa6.txt item: #172 of 2876 id: cord-007786-cu831tl7 author: Dondorp, Arjen M. title: Management of Severe Malaria and Severe Dengue in Resource-Limited Settings date: 2019-02-09 words: 4116 flesch: 38 summary: There is insufficient evidence to recommend fluid choice in severe dengue with hypotensive shock, but there is discussion among experts whether there is a role for colloids in severe dengue patients with hypotension, given the prominent role of capillary leak it its pathogenesis. The WHO guidelines for the management of patients with severe dengue distinguish patients with compensated shock from those with decompensated (hypotensive) shock [2, 27] . keywords: children; dengue; fluid; malaria; patients; shock; therapy cache: cord-007786-cu831tl7.txt plain text: cord-007786-cu831tl7.txt item: #173 of 2876 id: cord-007788-09t52zix author: Wallhult, Elisabeth title: Early and Acute Complications and the Principles of HSCT Nursing Care date: 2017-11-22 words: 13964 flesch: 41 summary: www.ukomic.co Guidelines for the assessment of oral mucositis in adult chemotherapy, radiotherapy and haematopoietic stem cell transplant patients Severe respiratory failure due to diffuse alveolar hemorrhage: clinical characteristics and outcome of intensive care Drug safety evaluation of defibrotide Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 Hematopoietic cell transplantationassociated thrombotic microangiopathy: a review of pathophysiology, diagnosis, and treatment Chapter 12: Infections after HSCT. HSCT patients are particularly at risk, especially during the neutropenic period following the conditioning treatment. keywords: blood; care; cell; complications; diagnosis; disease; et al; factors; hsct; infection; need; pain; patients; risk; sepsis; signs; sos; stem; symptoms; syndrome; transplantation; treatment; vod cache: cord-007788-09t52zix.txt plain text: cord-007788-09t52zix.txt item: #174 of 2876 id: cord-007798-9ht7cqhu author: Smith, Silas W. title: Drugs and pharmaceuticals: management of intoxication and antidotes date: 2010-02-25 words: 22607 flesch: 29 summary: Similarly, restricting activated charcoal (AC) administration to patients presenting to health care within the first hour post ingestion would exclude up to 90% of poisoned patients from the potential benefits of AC when administered beyond an hour [24, 33] . A small retrospective chart review found no adverse effects or allergic reactions in VPA overdose patients administered carnitine keywords: acetaminophen; acid; acute; administration; benefit; bicarbonate; calcium; cardiac; carnitine; case; channel; charcoal; concentrations; digoxin; doses; drug; effects; glucose; hours; hypoglycemia; i.v; infusion; ingestion; insulin; intoxication; leucovorin; management; methotrexate; mtx; naloxone; octreotide; oral; overdose; patients; poisoning; serum; sodium; studies; study; therapy; toxicity; treatment; use cache: cord-007798-9ht7cqhu.txt plain text: cord-007798-9ht7cqhu.txt item: #175 of 2876 id: cord-007818-jfp9uumb author: Papali, Alfred title: Infrastructure and Organization of Adult Intensive Care Units in Resource-Limited Settings date: 2019-02-09 words: 15076 flesch: 28 summary: We suggest that, if possible, ICUs use a closed-format model where physicians specifically trained or experienced in intensive care medicine direct patient care (2B). Controlled trial of upper room ultraviolet air disinfection: a basis for new dosing guidelines Guidelines for prevention of hospital acquired infections Guide to local production: WHO-recommended handrub formulations Shelf-life of chlorine solutions recommended in Ebola virus disease response Cost-effectiveness of a hand hygiene program on health care-associated infections in intensive care patients at a tertiary care hospital in Vietnam Cluster-randomized, crossover trial of the efficacy of plain soap and water versus alcohol-based rub for surgical hand preparation in a rural hospital in Kenya Muslim health-care workers and alcoholbased handrubs Current practices and barriers to the use of facemasks and respirators among hospital-based health care workers in Vietnam A cluster randomised trial of cloth masks compared with medical masks in healthcare workers Infection prevention and control (IPC) guidance summary: Ebola guidance package An approach to prioritization of medical devices in low-income countries: an example based on the Republic of South Sudan Determining the utility and durability of medical equipment donated to a rural clinic in a low-income country Mortality rates increase dramatically below a systolic blood pressure of 105-mm Hg in septic surgical patients Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial International study on microcirculatory shock occurrence in acutely ill patients Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3) Diagnosing acute respiratory distress syndrome in resource limited settings: the Kigali modification of the Berlin definition Hypoxaemia as a mortality risk factor in acute lower respiratory infections in children in low and middle-income countries: systematic review and meta-analysis Prevalence and predictors of hypoxaemia in respiratory and non-respiratory primary diagnoses among emergently ill children at a tertiary hospital in south western Nigeria Single deranged physiologic parameters are associated with mortality in a low-income country Severely deranged vital signs as triggers for acute treatment modifications on an intensive care unit in a lowincome country Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scaleup: a longitudinal cohort study Dynamic measurement of hemodynamic parameters and cardiac preload in adults with dengue: a prospective observational study Vital signs directed therapy: improving care in an intensive care unit in a low-income country Accuracy of oscillometric blood pressure measurement according to the relation between cuff size and upper-arm circumference in critically ill patients Tracking hypotension and dynamic changes in arterial blood pressure with brachial cuff measurements Results of a survey of blood pressure monitoring by intensivists in critically ill patients: a preliminary study Pulse oximetry for perioperative monitoring The use of the pulse oximetric saturation/fraction of inspired oxygen ratio for risk stratification of patients with severe sepsis and septic shock Ventilatory support of patients with sepsis or septic shock in resource-limited settings The use of portable ultrasound devices in low-and middle-income countries: a systematic review of the literature Impact of improved vaccination programme and intensive care facilities on incidence and outcome of tetanus in southern Vietnam Neonatal tetanus in Vietnam: comprehensive intensive care support improves mortality Impact of a structured ICU training programme in resource-limited settings in Asia Non-invasive ventilation for children with acute respiratory failure in the developing world: literature review and an implementation example Noninvasive mechanical ventilation: an 18-month experience of two tertiary care hospitals in north India A randomized clinical trial evaluating nasal continuous positive airway pressure for acute respiratory distress in a developing country Bubble continuous positive airway pressure for children with severe pneumonia and hypoxaemia in Bangladesh: an open, randomised controlled trial Use of nasal bubble CPAP in children with hypoxemic clinical pneumonia-report from a resource limited set-up Efficacy of a lowcost bubble CPAP system in treatment of respiratory distress in a neonatal ward in Malawi Continuous end-tidal carbon dioxide monitoring in pediatric intensive care units The use of end-tidal carbon dioxide monitoring to confirm endotracheal tube placement in adult and paediatric intensive care units in Australia and New Zealand keywords: blood; care; countries; critical; equipment; hand; healthcare; hospital; hygiene; icu; icus; infection; intensive; medicine; mortality; national; oxygen; patients; quality; resource; sepsis; settings; studies; study; supply; training; use cache: cord-007818-jfp9uumb.txt plain text: cord-007818-jfp9uumb.txt item: #176 of 2876 id: cord-007833-wkv808ix author: Modi, Dipenkumar title: Pomalidomide-Induced Pulmonary Toxicity in Multiple Myeloma date: 2015-12-16 words: 1341 flesch: 40 summary: Patients usually present with nonspecific symptoms mimicking pneumonia and respiratory failure. Because this drug is being increasingly used in multiple myeloma, it is very important to recognize this yet unknown severe adverse reaction in timely manner to avoid significant morbidity in patients. keywords: cumm; patient; pomalidomide; pulmonary; toxicity cache: cord-007833-wkv808ix.txt plain text: cord-007833-wkv808ix.txt item: #177 of 2876 id: cord-007865-1oyl6clq author: Walsh, Paul title: Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed date: 2008-02-21 words: 2440 flesch: 55 summary: If one were to seek the input of interested members of the general public, then where better to look than those whose family or friends are currently ED patients? key: cord-007865-1oyl6clq authors: Walsh, Paul; Cortez, Valarie; Bhakta, Himanshu title: Patients Would Prefer Ward to Emergency Department Boarding While Awaiting an Inpatient Bed date: 2008-02-21 journal: J Emerg Med DOI: 10.1016/j.jemermed.2007.05.012 sha: doc_id: 7865 cord_uid: 1oyl6clq Boarding of admitted patients in the Emergency Department (ED), rather than in inpatient care areas, is widespread. keywords: boarding; emergency; inpatient; patients; ward cache: cord-007865-1oyl6clq.txt plain text: cord-007865-1oyl6clq.txt item: #178 of 2876 id: cord-007890-bie1veti author: None title: ECC-4 Abstracts date: 2002-04-16 words: 86133 flesch: 45 summary: On the whole, E. coli showed an elevated sensitivity rate ( !/90% of tested strains) to nitrofurantoin, gentamicin, amikacin, and 2nd-and 3rd-generation cephalosporins, while only amoxicillin and piperacillin had a mean resistance rate !/30 % for M41L, D67N, K103N, M184V, L210W, T215YF, and for L10I, M36I, L63P, A71VT, L90M for P Inhibitors (PI). keywords: acid; activity; acute; administration; aeruginosa; agar; agents; aim; amoxicillin; analysis; antibiotic; antimicrobial; associated; aureus; b b; bacteria; beta; blood; candida; care; cases; cells; children; chronic; ciprofloxacin; clinical; coli; combination; concentrations; conclusion; control; cultures; data; days; department; diagnosis; disease; dna; dose; drug; effect; efficacy; erythromycin; esbl; fever; following; france; general; gentamicin; gram; group; haart; hcv; health; hepatitis; high; hiv; hospital; human; ifn; imipenem; incidence; infected; infection; influenza; institute; isolates; l b; laboratory; level; linezolid; mean; medical; medicine; methods; microbiology; mics; months; mrsa; nccls; negative; new; non; nosocomial; number; oral; patients; pcr; penicillin; period; plasma; pneumoniae; positive; presence; present; prevalence; pts; purpose; rate; resistance; results; risk; rna; samples; school; sensitivity; serum; spain; species; specific; spp; staphylococcus; strains; streptococcus; study; susceptibility; system; teicoplanin; tested; therapy; time; tissue; total; tract; treatment; university; urinary; urine; use; vancomycin; virus; vitro; years cache: cord-007890-bie1veti.txt plain text: cord-007890-bie1veti.txt item: #179 of 2876 id: cord-008596-zhk82cor author: Watts, Clark title: Erosion of physician autonomy and public respect for the profession() date: 2008-07-09 words: 3902 flesch: 50 summary: Surg Neurol DOI: 10.1016/j.surneu.2008.05.005 sha: doc_id: 8596 cord_uid: zhk82cor nan Erosion of physician autonomy and public respect for the profession At the beginning of the second half of the 20th century, physicians held an enviable position of autonomy and respect within the health care industry This has further reduced physician autonomy and has contributed significantly, for example, to the adversarial nature of hospital peer review of physicians, which is carried out according to hospital rules written by hospital lawyers for the purpose of lessening hospital liability at the expense of physician independence [17] . keywords: care; health; health care; hospital; patients; physicians; public; system cache: cord-008596-zhk82cor.txt plain text: cord-008596-zhk82cor.txt item: #180 of 2876 id: cord-008672-luoxomif author: Mwachari, C. title: Chronic diarrhoea among HIV-infected adult patients in Nairobi, Kenya date: 2004-10-29 words: 3177 flesch: 44 summary: A significant association between colonization with adherent E. coli and chronic diarrhoea and wasting in AIDS patients has been demonstrated by Kotler et al., 19 who found such strains in 17% of study patients in the USA. ~ It is possible that novel agents remain to be characterized and associated with chronic diarrhoea and wasting in HIV patients, and HIV itself may be the cause of chronic diarrhoea in some patients. keywords: chronic; coli; culture; diarrhoea; hiv; patients; stool; study cache: cord-008672-luoxomif.txt plain text: cord-008672-luoxomif.txt item: #181 of 2876 id: cord-008695-y7il3hyb author: None title: Pandemic Flu: Clinical management of patients with an influenza-like illness during an influenza pandemic date: 2007-01-25 words: 25930 flesch: 41 summary: London: Health Protection Agency The epidemiology and clinical impact of pandemic influenza The contribution of influenza to combined acute respiratory infections, hospital admissions, and deaths in winter Pandemic versus epidemic influenza mortality: a pattern of changing age distribution Delaying the international spread of pandemic influenza Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study Viral respiratory infections in the institutionalized elderly: clinical and epidemiologic findings Does this patient have influenza? Clinical signs and symptoms predicting influenza infection Predicting influenza infections during epidemics with use of a clinical case definition The predictive value of influenza symptomatology in elderly people Randomized, placebocontrolled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysis Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. Furthermore, the presence of an influenza-like illness (ILI) comprising of a combination of fever, cough, sore throat, myalgia and headache is not specific for influenza infection. keywords: acute; adults; antibiotic; bacterial; care; children; clinical; community; complications; days; disease; fever; hospital; illness; infection; influenza; influenza pandemic; management; oseltamivir; pandemic; patients; pneumonia; respiratory; therapy; treatment; virus cache: cord-008695-y7il3hyb.txt plain text: cord-008695-y7il3hyb.txt item: #182 of 2876 id: cord-009278-98ebmd33 author: Ferreira-Coimbra, João title: Burden of Community-Acquired Pneumonia and Unmet Clinical Needs date: 2020-02-18 words: 5576 flesch: 35 summary: One-ninth of patients hospitalized with CAP will need intensive care unit (ICU) admission because of severe respiratory failure, severe sepsis, or septic shock [32, 33] and CAP mortality in these patients remains very high, reaching near 50% CAP mortality reflects the enrollment of different patient populations in epidemiological studies as well as their methodology. keywords: adults; cap; community; disease; incidence; mortality; new; patients; pneumonia; study; years cache: cord-009278-98ebmd33.txt plain text: cord-009278-98ebmd33.txt item: #183 of 2876 id: cord-009285-1ddfywfa author: Assicot, M. title: High serum procalcitonin concentrations in patients with sepsis and infection date: 1993-02-27 words: 2596 flesch: 29 summary: key: cord-009285-1ddfywfa authors: Assicot, M.; Bohuon, C.; Gendrel, D.; Raymond, J.; Carsin, H.; Guilbaud, J. title: High serum procalcitonin concentrations in patients with sepsis and infection date: 1993-02-27 journal: Lancet DOI: 10.1016/0140-6736(93)90277-n sha: doc_id: 9285 cord_uid: 1ddfywfa High concentrations of calcitonin-like immunoreactivity have been found in the blood of patients with various extrathyroid diseases. Plasma immunoreactive-calcitonin in patients with non-thyroid tumours Hypersecretion of calcitonin in neoplastic conditions Increased serum and urinary calcitonin levels in patients with pulmonary disease Hypercalcitoninemia in acute pancreatitis Serum calcitonin in acute pancreatitis in man Calcitonin levels in chronic renal disease Immunoreactive parathyroidhormone and calcitonin in plasma and ultrafiltrate before and after haemodialysis Identification and measurement of calcitonin precursors in serum of patients with malignant diseases Hypercalcitoninaemia in fulminant meningococcaemia in children Immunochemical heterogeneity of calcitonin in tumor, tumor venous effluent and peripheral blood of patients with medullary thyroid carcinoma Immunochemical heterogeneity of calcitonin in plasma Medullary thyroid carcinoma secretes a non-calcitonin peptide corresponding to the carboxylterminal region of preprocalcitonin Diagnostic relevance of the amino-terminal cleavage peptide of procalcitonin (PAS-57), calcitonin and calcitonin gene-related peptide in medullary thyroid carcinoma patients Structural characterization of a high-molecular-mass form of calcitonin [procalcitonin-(60-116) -peptide] and its corresponding N-terminal flanking peptide [procalcitonin-(1-57)-peptide] in a human medullary thyroid carcinoma Immunocytochemical localization of calcitonin in Kultschitzky cells of human lung A novel calcitonin carboxy-terminal peptide produced in medullary thyroid carcinoma by alternative RNA processing of the calcitonin/calcitonin gene-related peptide gene Calcitonin gene-related peptide levels are elevated in patients with sepsis Endogenous fibrinolysis may play a part in acute upper-gastrointestinal-tract bleeding by causing digestion of haemostatic plugs. keywords: calcitonin; concentrations; patients; procalcitonin cache: cord-009285-1ddfywfa.txt plain text: cord-009285-1ddfywfa.txt item: #184 of 2876 id: cord-009322-7l7slziv author: Kraetsch, Hans-Georg title: Verlauf und prognostische Parameter bei Still-Syndrom des Erwachsenen: Eigene Erfahrungen und Literaturübersicht date: 1997 words: 2074 flesch: 51 summary: Die Erkrankung ist weltweit verbreitet; vorwiegend sind junge Erwachsene zwischen 16 und 35 Jahren betroffen. Die fiitiologie der Erkrankung ist unldar. keywords: adult; als; aosd; auch; bei; chronic; der; die; disease; eine; mit; onset; patienten; patients; sind; und cache: cord-009322-7l7slziv.txt plain text: cord-009322-7l7slziv.txt item: #185 of 2876 id: cord-009360-rgwe2pkx author: Pilatz, Adrian title: High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval date: 2019-08-27 words: 4293 flesch: 27 summary: Statistical analysis was done to investigate possible associations between different variables associated with urogenital tract inflammation/infection and the outcome of testicular sperm retrieval, testicular inflammation and other clinical parameters. Pathologic features of the epididymis in patients with epididymal obstructive azoospermia: Observation of 11 cases Male infertility: A public health issue caused by sexually transmitted pathogens Aetiology of obstructive azoospermia in Chinese infertility patients Microbiota of the seminal fluid from healthy and infertile men Hidden pathogens uncovered: Metagenomic analysis of urinary tract infections Distinct polymicrobial populations in a chronic foot ulcer with implications for diagnostics and anti-infective therapy European Association of Urology guidelines on male infertility: The 2012 update Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia Epididymal more than testicular abnormalities are associated with the occurrence of antisperm antibodies as evaluated by the MAR test Seminal, clinical and colour-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples Ultrasound of the male genital tract in relation to male reproductive health DNA fragmentation in two cytometric sperm populations: Relationship with clinical and ultrasound characteristics of the male genital tract Necrosis is the dominant cell death pathway in uropathogenic Escherichia coli elicited epididymoorchitis and is responsible for damage of rat testis Immunocytological analysis of leukocyte subpopulations in urine specimens before and after prostatic massage Impact of sexual debut on culturable human seminal microbiota Combined trifocal and microsurgical testicular sperm extraction is the best technique for testicular sperm retrieval in low-chance nonobstructive azoospermia Presence of human papillomavirus DNA in testicular biopsies from nonobstructive azoospermic men Uropathogenic Escherichia coli causes fibrotic remodelling of the epididymis Prevalence of human herpes virus types 1-7 in the semen of men attending an infertility clinic and correlation with semen parameters How does the pre-massage and post-massage 2-glass test compare to the Meares-Stamey 4-glass test in men with chronic prostatitis/chronic pelvic pain syndrome Testicular function after unilateral bacterial epididymo-orchitis Ultrasonographic determination of caput epididymis diameter is strongly predictive of obstruction in the genital tract in azoospermic men with normal serum FSH Color Doppler ultrasound imaging in varicoceles: Is the venous diameter sufficient for predicting clinical and subclinical varicocele? Acute epididymitis revisited: Impact of molecular diagnostics on etiology and contemporary guideline recommendations Metabolic syndrome and the seminal cytokine network in morbidly obese males Reference values for testicular volume, epididymal head size and peak systolic velocity of the testicular artery in adult males measured by ultrasonography Acute epididymitis in ultrasound: Results of a prospective study with baseline and follow-up investigations in 134 patients WHO manual for the standardized investigation, diagnosis and management of the infertile male Influence of urogenital infections and inflammation on semen quality and male fertility Chronic orchitis: A neglected cause of male infertility? keywords: azoospermia; et al; infection; infertility; inflammation; patients; retrieval; sperm; testicular; tract cache: cord-009360-rgwe2pkx.txt plain text: cord-009360-rgwe2pkx.txt item: #186 of 2876 id: cord-009417-458rrhcm author: Luce, Judith A. title: Use of Blood Components in the Intensive Care Unit date: 2009-05-15 words: 17116 flesch: 37 summary: Oxygen extraction ratio: A valid indicator of transfusion need in limited coronary vascular reserve? for the ABC Investigators: Anemia and blood transfusion in critically ill patients The CRIT study: Anemia and blood transfusion in the critically ill-current clinical practice in the United States Red cell transfusion practice following the Transfusion Requirements in Critical Care (TRICC) study: Prospective observational cohort study in a large UK intensive care unit Appropriateness of red blood cell transfusion in Australasian intensive care practice Silent myocardial ischaemia and haemoglobin concentration: A randomized controlled trial of transfusion strategy in lower limb arthroplasty Mathematical analysis of isovolemic hemodilution indicates that it can decrease the need for allogeneic blood transfusion Guidelines for perioperative red blood cell transfusions American Society of Anesthesiologists Task Force: Practice guidelines for blood component therapy Prudent strategies for elective red blood cell transfusion Platelet transfusion therapy. The majority of blood transfusions are in the form of PRBCs, the component indicated for normovolemic patients or those for whom intravascular volume constraints are necessary. keywords: acute; associated; benefi; bleeding; blood; blood transfusion; care; cell; coagulation; components; disease; donor; factor; ffp; oxygen; patients; plasma; platelet; reactions; recipient; red; risk; storage; time; transfusion; transmission; unit; use; volume cache: cord-009417-458rrhcm.txt plain text: cord-009417-458rrhcm.txt item: #187 of 2876 id: cord-009507-l74c9x0n author: Singh, Amandeep title: Clinicopathological Conference: Fever, Productive Cough, and Tachycardia in a 22‐year‐old Asian Male date: 2008-01-08 words: 4402 flesch: 40 summary: Large pericardial effusions are most common with tumors, tuberculosis pericarditis, cholesterol pericarditis, myxedema, vasculitis/connective tissue disease, uremic pericarditis, and parasitoses. To summarize, this patient's recent immigration, symptoms of intermittent fever and of chronic cough that failed to respond to outpatient antibiotics, and development of large pericardial effusion all are consistent with a diagnosis of tuberculosis. keywords: chest; cough; disease; effusion; fever; infection; patient; pericarditis; symptoms; tuberculosis cache: cord-009507-l74c9x0n.txt plain text: cord-009507-l74c9x0n.txt item: #188 of 2876 id: cord-009512-o4y9s8zf author: Huang, Jiajia title: Primary pulmonary non‐Hodgkin's lymphoma: A retrospective analysis of 29 cases in a Chinese population date: 2010-03-24 words: 21960 flesch: 47 summary: Sickle cell patients develop organ damage irrespective of their frequency of acute painful events, which has been related to significant morbidity and increased mortality, and it seems likely that SCD-related organ damage negatively impacts QoL of sickle cell patients [6] . These data suggest that frequent painful and unpredictable crises are an important psychological burden rather than a physical burden to sickle cell patients as has been suggested previously [12] . keywords: acute; analysis; cancer; care; cases; cell; chl; chronic; cml; damage; diagnosis; disease; expression; factor; gvhd; hoct1; hodgkin; leukemia; level; lines; lymphoma; mrna; mutation; patients; physicians; primary; qol; response; sct; study; survivors; survivorship; tp53; treatment; tumor cache: cord-009512-o4y9s8zf.txt plain text: cord-009512-o4y9s8zf.txt item: #189 of 2876 id: cord-009567-osstpum6 author: None title: Abstracts Oral date: 2008-04-23 words: 131515 flesch: 49 summary: This graft infiltration by recipient cells was more pronounced with vascularized skin grafts, and to a higher degree in heart transplants. Recipient cells similarly infiltrated allogeneic grafts early on and in larger numbers than for syngeneic grafts by day 4/5 post-transplantation. keywords: activation; activity; acute; age; allogeneic; allograft; allograft rejection; allograft survival; amr; analysis; anti; antibodies; antibody; antigen; b cells; background; balb; biopsies; biopsy; blood; c4d; cardiac; cd25; cd4; cd4 t; cd8; center; chronic; clinical; cmv; cni; conclusion; control; creatinine; criteria; data; days; death; development; disease; donor; donor cells; donor kidney; dose; dsa; effect; expression; factors; failure; flow; follow; foxp3; function; gene; gfr; graft; graft function; graft loss; graft rejection; graft survival; group; heart; high; hla; human; immune; immunosuppression; incidence; increase; induction; infection; injury; ischemia; islet; kidney; kidney recipients; kidney transplant; levels; liver; liver graft; liver transplantation; loss; low; mean; median; meld; methods; mice; mmf; model; months; mrna; negative; nk cells; non; number; organ; outcomes; patients; period; population; positive; post; post transplant; potential; presence; primary; production; proliferation; pts; rates; recipients; regulatory; rejection; renal; response; results; risk; role; serum; specific; study; survival; t cells; tacrolimus; term; therapy; time; tlr4; tolerance; total; transplant; transplant patients; transplant recipients; transplantation; treatment; treg; treg cells; type; university; use; vitro; vivo; vs.; year cache: cord-009567-osstpum6.txt plain text: cord-009567-osstpum6.txt item: #190 of 2876 id: cord-009571-mygj2nd4 author: None title: Proceedings of the 42nd annual meeting of the american rheumatism association a section of the arthritis foundation june 1 & 2, 1978 new york city abstracts of papers presented date: 2005-11-23 words: 46205 flesch: 47 summary: Ten of 11 boys had disease onset prior to sexual maturation, whereas disease began after menarche in ADCC activity between patient cells and control cells when either the mixed mononuclear population or monocyte-depleted population were studied as effectors. Urate clear-ance appears to be the major determinant of serum uric acid concentration even in sickle cell patients with urate overproduction. keywords: acid; activity; anti; antibodies; antibody; antigen; arthritis; assay; binding; blood; bone; cartilage; cells; changes; complement; complexes; control; disease; dna; erythematosus; fluid; group; high; human; igg; igm; immune; joint; levels; lupus; lymphocytes; mean; mice; months; negative; normal; patients; positive; presence; present; renal; response; results; rheumatoid; sera; serum; sle; sle patients; studies; study; synovial; tissue; treatment; type; urate; years cache: cord-009571-mygj2nd4.txt plain text: cord-009571-mygj2nd4.txt item: #191 of 2876 id: cord-009575-bd67ph64 author: Berr, C. title: Risk factors in multiple sclerosis: a population‐based case‐control study in Hautes‐Pyrénées, France date: 2009-01-29 words: 1966 flesch: 53 summary: There was no relationship between age at menarche and age at MS onset in MS patients. Guidelines for research protocols Statistical methods for rates and proportions On the evaluation of disability in multiple sclerosis The geographic distribution of multiple sclerosis: an update with special reference to Europe and the Mediterranean region Referral bias in multiple sclerosis research Clinical features of multiple sclerosis in north east Scotland Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients Multiple sclerosis in the Orkney and Shetland Islands. keywords: age; controls; patients; sclerosis cache: cord-009575-bd67ph64.txt plain text: cord-009575-bd67ph64.txt item: #192 of 2876 id: cord-009664-kb9fnbgy author: None title: Oral presentations date: 2014-12-24 words: 71226 flesch: 44 summary: Resistance to penicillin, clindamycin and tetracycline fluctuated over time at~75%, 4−8% and 2−10% respectively. The median expected power was 10.0% (IQR, 7.2−13.6%) for a risk ratio for mortality of 0.85 between the compared groups; 14.7% (IQR, 10.6−21.8%) for a risk ratio of 0.80; and 7.9% (IQR, 6.3−10.2%) for a reduction in mortality from 30% to 25%. keywords: age; analysis; antibiotic; assay; associated; aureus; bacterial; blood; cases; cause; cdi; cells; clinical; common; community; conclusion; control; countries; culture; data; days; detection; diagnosis; different; difficile; disease; dna; drug; efflux; europe; expression; factors; gene; group; high; hospital; human; identification; incidence; increase; infections; influenza; isolates; laboratory; levels; like; methods; microbiology; model; mortality; mrsa; n =; negative; new; non; number; objectives; pathogens; patients; pcr; period; plasmid; pneumoniae; population; positive; potential; presence; present; prevalence; pvl; range; rate; resistance; resistance genes; response; results; risk; role; samples; screening; sensitivity; sequence; species; specimens; spread; strains; studies; study; susceptibility; system; testing; therapy; time; total; treatment; type; use; virus; years cache: cord-009664-kb9fnbgy.txt plain text: cord-009664-kb9fnbgy.txt item: #193 of 2876 id: cord-009667-8r8j0h08 author: Cao, Bin title: Diagnosis and treatment of community‐acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society, Chinese Medical Association date: 2017-09-26 words: 11056 flesch: 20 summary: Late admission to the ICU in patients with community-acquired pneumonia is associated with higher mortality Time to intubation is associated with outcome in patients with community-acquired pneumonia National Health and Family Planning Commission Statistical Information Center Etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in China Etiological analysis and predictive diagnostic model building of communityacquired pneumonia in adult outpatients in Beijing, China Viral and Mycoplasma pneumoniae community-acquired pneumonia and novel clinical outcome evaluation in ambulatory adult patients in China The incidence and etiology of community-acquired pneumonia in fever outpatients A multicentre study on the pathogenic agents in 665 adult patients with community-acquired pneumonia in cities of China Causative agent distribution and antibiotic therapy assessment among adult patients with community acquired pneumonia in Chinese urban population Community-acquired, methicillin-resistant Staphylococcus aureus isolated from children with community-onset pneumonia in China Community-acquired necrotizing pneumonia caused by methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin in a Chinese teenager: case report and literature review Whole genome analysis of a community-associated methicillin-resistant Staphylococcus aureus ST59 isolate from a case of human sepsis and severe pneumonia in China One case of communityacquired methicillin-resistant necrotic Staphylococcus aureus pneumonia with concomitant bloodstream infection Antimicrobial susceptibility of community-acquired respiratory tract pathogens isolated from adults in China during 2009 and 2010 Community-acquired pneumonia through Enterobacteriaceae and Pseudomonas aeruginosa: diagnosis, incidence and predictors Community-acquired pneumonia due to gram-negative bacteria and pseudomonas aeruginosa: incidence, risk, and prognosis Viral etiology of communityacquired pneumonia among adolescents and adults with mild or moderate severity and its relation to age and severity Respiratory virus is a real pathogen in immunocompetent community-acquired pneumonia: comparing to influenza like illness and volunteer controls Resistance surveillance of major pathogens for adult community-acquired respiratory tract infections in China: a multicenter study 2012 The effect of macrolide resistance on the presentation and outcome of patients hospitalized for Streptococcus pneumoniae pneumonia assessment and treatment Patterns of resolution of chest radiograph abnormalities in adults hospitalized with severe community-acquired pneumonia Pneumonia recovery: discrepancies in perspectives of the radiologist, physician and patient Towards a sensible comprehension of severe community-acquired pneumonia Treatment failure in communityacquired pneumonia Causes and factors associated with early failure in hospitalized patients with community-acquired pneumonia C-reactive protein is an independent predictor of severity in community-acquired pneumonia Markers of treatment failure in hospitalised community acquired pneumonia Usefulness of consecutive C-reactive protein measurements in follow-up of severe community-acquired pneumonia Stability in community-acquired pneumonia: one step forward with markers? Etiologic diagnosis of adult bacterial pneumonia by culture and PCR applied to respiratory tract samples Limited value of routine microbiological diagnostics in patients hospitalized for community-acquired pneumonia keywords: acute; adults; aspiration; cap; china; clinical; community; diagnosis; disease; failure; infection; influenza; management; patients; pneumonia; respiratory; risk; study; therapy; treatment; virus cache: cord-009667-8r8j0h08.txt plain text: cord-009667-8r8j0h08.txt item: #194 of 2876 id: cord-009697-dq4y89ab author: Yuen, Eddie title: Role of absolute lymphocyte count in the screening of patients with suspected SARS date: 2003-07-25 words: 1511 flesch: 55 summary: These results support the conclusion that magnesium sulphate is a weak bronchodilator and may be a useful adjunct to standard therapy in patients with acute severe asthma. Second, a multicentre, placebo-controlled, randomized, double-blind trial of intravenous magnesium sulphate in 248 patients with acute severe asthma was recently reported. keywords: group; magnesium; patients; sars cache: cord-009697-dq4y89ab.txt plain text: cord-009697-dq4y89ab.txt item: #195 of 2876 id: cord-009713-sxd4t2tz author: None title: Poster Presentations date: 2020-01-10 words: 44058 flesch: 48 summary: Long-term safety and efficacy of adjunctive perampanel in paediatric patients (aged 4 to <12y) with partial-onset seizures (POS) or primary generalised tonic-clonic seizures (PGTCS) in Study 311 R FLAMINI 1 , A PATTEN 2 , LY NGO 3 1 Pediatric and Adolescent Neurodevelopmental Associates, Atlanta, GA, USA; 2 Eisai Ltd., Hatfield, Hertfordshire, UK; 3 Eisai Inc., Woodcliff Lake, NJ, USA Objective: Study 311 (NCT02849626) was a multicentre, openlabel, single-arm study of perampanel oral suspension (0.5mg/ mL) in paediatric patients (aged 4 to <12y) with POS (with/ without secondarily generalised seizures Here, we report long-term (1y) safety and efficacy data of adjunctive perampanel in paediatric patients from Study 311. keywords: acute; age; analysis; associated; brain; care; cases; children; cohort; conclusions; data; day; days; delay; developmental; diagnosis; disease; disorder; dystonia; eeg; epilepsy; features; following; function; gene; group; history; hospital; imaging; investigations; management; mean; median; methods; months; motor; mri; mutation; neurology; non; normal; objective; onset; outcomes; paediatric; parents; patients; poster; presentation; range; report; results; review; seizures; study; symptoms; syndrome; term; time; treatment; weakness; weeks; years cache: cord-009713-sxd4t2tz.txt plain text: cord-009713-sxd4t2tz.txt item: #196 of 2876 id: cord-009788-bc6sc2rc author: Ferguson, J. K. title: Preventing healthcare‐associated infection: risks, healthcare systems and behaviour date: 2009-09-17 words: 3555 flesch: 35 summary: Modern healthcare generates a wide range of infection risks for patients through practices that severely compromise host defences against infection and promote colonization by pathogenic hospital strains of bacteria. 1 Bloodstream infections, surgical site infections, intensive care infections, infections and colonizations due to multiresistant organisms are usually documented by routine surveillance systems and reported to State and National bodies. keywords: hai; hand; healthcare; infection; mrsa; patients; practice; risk; staff cache: cord-009788-bc6sc2rc.txt plain text: cord-009788-bc6sc2rc.txt item: #197 of 2876 id: cord-009891-gqrhbhbn author: Rassool, G. Hussein title: Current issues and forthcoming events date: 2003-09-03 words: 3467 flesch: 45 summary: The report indicates that the key to better management of cancer pain is improved educational programmes and the development of dedicated pain management teams. The severity of cancer pain is often dependent on the type of cancer and stage of the disease. keywords: cancer; health; nursing; pain; patients; physicians; sars; treatment; vaccine cache: cord-009891-gqrhbhbn.txt plain text: cord-009891-gqrhbhbn.txt item: #198 of 2876 id: cord-009967-fyqc5bat author: Gleckman, Richard title: Cost‐Effective Antibiotic Prescribing date: 2012-01-24 words: 5939 flesch: 23 summary: In 1973, it was reported that favorable results ensued when oral antibiotic therapy was prescribed for hospitalized patients with serious infectionsz3 Fourteen patients with osteomyelitis were treated successfully with oral cephalexin after they had received a short course of parenteral cephaloridine. Therapy of osteomyelitis and suppurative arthritis High-dose dicloxacillin treatment of acute staphylococcal osteomyelitis in children Long-term follow-up of ambulatory management of osteomyelitis Success with cephalordine-cephalexin therapy Use of the serum bactericidal titer to assess the adequacy of oral antibiotic therapy in the treatment of acute hematogenous osteomyelitis Marks MI et at. keywords: antibiotic; cost; drug; home; hospital; infections; intravenous; patients; prophylaxis; therapy; treatment; use cache: cord-009967-fyqc5bat.txt plain text: cord-009967-fyqc5bat.txt item: #199 of 2876 id: cord-009982-zgbu46fo author: Cies, Jeffrey J. title: Peramivir for Influenza A and B Viral Infections: A Pharmacokinetic Case Series date: 2019-10-04 words: 2903 flesch: 35 summary: 2 A single multicenter, open-label, uncontrolled study assessed the efficacy, safety, and pharmacokinetics of PRV in pediatric patients during the 2009 pandemic H1N1 influenza A epidemic. The authors concluded that a standardized, weight-based dosing regimen in pediatric patients had similar efficacy and safety outcomes when compared with adult patients. keywords: dosing; drug; influenza; patients; pharmacokinetics; picu; prv cache: cord-009982-zgbu46fo.txt plain text: cord-009982-zgbu46fo.txt item: #200 of 2876 id: cord-009997-oecpqf1j author: None title: 2018 ASPHO ABSTRACTS date: 2018-03-31 words: 182444 flesch: 45 summary: Of included patients, 165 had treatment intensity of 2 (41.0%), 192 of 3 (47.8%) and 45 of 4 (11.2%). After 2 cycles of treatment patient was no longer requiring oxygen and was ambulating without assistance. keywords: acute; addition; adherence; adult patients; age; aml; aml patients; analysis; anemia; anti; average; background; baseline; biopsy; bleeding; blood; blood cell; bone; cancer; cancer patients; care; cases; cell; cell disease; center; chart; chemotherapy; childhood; children; chronic; clinical; cohort; complications; conclusion; control; count; course; cycles; data; days; death; design; development; diagnosis; differences; disease; dose; effects; efficacy; end; episodes; evaluation; events; evidence; expression; factors; failure; family; female; fever; findings; following; function; gene; grade; group; guidelines; health; hemoglobin; high; history; hospital; hsct patients; hydroxyurea; imaging; immune; impact; improvement; incidence; increase; induction; infection; initial; institution; intervention; iron; laboratory; lesions; leukemia; levels; life; literature; liver; loss; low; lymphoma; male; management; marrow; mean; median; medical; metastatic; method; months; mortality; multiple; mutations; n =; need; negative; neuroblastoma; neuroblastoma patients; neutropenia; new; non; normal; novel; number; objectives; oncology patients; outcomes; p =; pain; parents; patients; pediatric; period; platelet; population; positive; post; potential; present; presentation; primary; program; providers; range; rates; relapse; report; required; research; response; results; review; risk; risk patients; role; scd patients; scores; screening; severe; sickle; sirolimus; specific; stage; standard; states; states background; stem; studies; study; support; survival; survivors; symptoms; syndrome; term; testing; therapy; thrombocytopenia; time; total; transfusion; transplant; treatment; tumor; type; united; use; weeks; years cache: cord-009997-oecpqf1j.txt plain text: cord-009997-oecpqf1j.txt item: #201 of 2876 id: cord-010027-r0tl01kq author: None title: Dublin Pathology 2015. 8th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland date: 2015-09-15 words: 36337 flesch: 44 summary: Tumoral melanosis refers to complete regression of a melanoma, a diagnosis that it is often missed because of the absence of tumour cells within the regressed area. Background: During the metastatic cascade, circulating tumour cells rapidly and efficiently adopt a platelet cloak. keywords: analysis; benign; biopsies; biopsy; breast; cancer; carcinoma; cases; cell; changes; data; diagnosis; digital; disease; dna; expression; features; findings; genes; grade; hospital; immunohistochemistry; lesions; lines; lung; lymphoma; melanoma; methods; molecular; mutations; negative; non; number; ovarian; pathology; patients; potential; practice; primary; protein; quality; report; resection; results; review; risk; role; samples; sequencing; specific; specimens; staining; status; study; survival; testing; time; tissue; treatment; tumour; use; years cache: cord-010027-r0tl01kq.txt plain text: cord-010027-r0tl01kq.txt item: #202 of 2876 id: cord-010036-6czkzek0 author: Lorentz, I T title: Treatment of idiopathic spasmodic torticollis with botulinum‐A toxin: a pilot study of 19 patients date: 1990-05-01 words: 3200 flesch: 48 summary: Botulinum toxin injection for the treatment of orornandibular dystonia Local treatment of spasmodic torticollis with botulinum toxin Double blind study of botulinum toxin in spasmodic torticollis Botulinum toxin in spasmodic torticollis Controlled trial of botulinum toxin injections in the treatment of spasmodic torticollis Treatment of idiopathic spasmodic torticollis with botulinum After giving informed consent, the patients were offered botulinum toxin treatment. keywords: botulinum; dystonia; patients; torticollis; toxin; treatment; years cache: cord-010036-6czkzek0.txt plain text: cord-010036-6czkzek0.txt item: #203 of 2876 id: cord-010075-72jodunj author: None title: Paediatric SIG: Poster Session date: 2011-03-21 words: 32065 flesch: 52 summary: Results mRNA stability studies indicated that B 1 R SV was ≈35% less stable than the WT transcript in H2126 cells suggesting a stabilizing element 5'UTR. Lower fi bre intake in asthmatic subjects (n = 124) was associated with lower %predicted FEV 1 (r = 0.41, p = 0.004), %FVC (r = 0.43, p = 0.015) and FEV 1 /FVC keywords: acute; age; aim; airway; asm; asthma; cells; children; conclusions; confl; control; copd; cough; data; days; disease; expression; function; group; hospital; hrv; ict; identifi; infection; infl; interest; levels; lung; mean; methods; months; n =; non; p =; patients; post; pulmonary; range; respiratory; results; signifi; studies; study; subjects; symptoms; time; treatment; use; years cache: cord-010075-72jodunj.txt plain text: cord-010075-72jodunj.txt item: #204 of 2876 id: cord-010078-8lkkez3n author: None title: Invited Speakers date: 2010-11-24 words: 21364 flesch: 41 summary: The SIRT1 is decreased in alveolar macrophages of smokers and COPD patients, and associated with pro-infl ammatory response through the activation of NF-κB. Understanding the complexity of infl ammatory and epigenetic regulations in chronic lung diseases may potentiate the development of novel therapies. In China, non-smokers accounted for 38.6% of COPD patients compared with 24.9% in USA and 22.9% in the UK. keywords: acute; airway; asthma; bronchitis; cancer; care; cells; chronic; copd; copd patients; cough; countries; data; diagnosis; disease; factors; function; group; health; infl; lung; new; non; patients; pleural; prevalence; pulmonary; risk; signifi; smoking; stage; studies; study; symptoms; therapy; treatment; trials; use cache: cord-010078-8lkkez3n.txt plain text: cord-010078-8lkkez3n.txt item: #205 of 2876 id: cord-010088-s9tfvtao author: None title: Oral Abstracts date: 2013-11-01 words: 43554 flesch: 46 summary: The information of blood donors with rare blood types is registered into the National Registering System for Blood Donors with Rare Blood Types by professional technician from organizations join the program. Present methods to recruit blood donors based on age, gender and occupation groups for a stable blood supply. keywords: aims; anti; antibodies; antibody; antigens; background; blood; blood components; blood donation; blood donors; blood group; blood products; blood transfusion; cases; cells; collection; data; day; development; events; group; haemovigilance; hbv; hcv; health; hit; hla; identification; immune; infection; international; inventory; management; methods; national; non; patients; plasma; platelet; platelet transfusion; population; positive; process; production; products; quality; reactions; red; results; risk; safety; samples; study; system; testing; therapy; time; transfusion; treatment; use; years cache: cord-010088-s9tfvtao.txt plain text: cord-010088-s9tfvtao.txt item: #206 of 2876 id: cord-010092-uftc8inx author: None title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 words: 233543 flesch: 50 summary: One central question is the need of individual NAT screening (ID) versus minipool NAT screening (MP) approaches to identify all relevant viremias in blood donors. 3A-S02-03 Background: The screening of blood donors and returning travelers from active transmission areas have highlighted the importance of diagnosis of acute arboviral infections. keywords: abo blood; addition; aims; allele; alloimmunization; analysis; anemia; anti; antibodies; antibody; antigen; apheresis; approach; assay; available; average; background; bacterial; bleeding; blood bank; blood cells; blood center; blood chimerism; blood collection; blood components; blood count; blood culture; blood demand; blood donation; blood donors; blood establishments; blood flow; blood group; blood grouping; blood loss; blood management; blood plasma; blood platelet; blood pressure; blood processing; blood products; blood results; blood safety; blood samples; blood services; blood supply; blood system; blood test; blood transfusion; blood type; blood units; blood volume; care; cases; cause; cell donors; cell transfusion; clinical; concentrates; concentration; conclusions; confirmed; content; control; cord blood; countries; criteria; cross; current; data; day; days; deferral; detection; difference; disease; dna; donations; donor samples; effect; events; evidence; exon; expression; factors; female; ferritin; flow; following; frequency; gel; gene; genotyping; group system; groups; hbv; hcv; health; hemoglobin; hev; history; hiv; hla; hospital; hospital blood; human; identification; igg; impact; incidence; increase; individuals; infection; information; international; iron; laboratory; levels; life; low; major; mean; median; medical; methods; min; ml blood; model; molecular; months; n =; national; need; negative; new; non; number; order; overall; p =; patients; pcr; pcs; period; phenotype; plasma; plasma donors; plasma transfusion; platelet; platelet donors; platelet transfusion; population; positive; post; potential; practice; presence; present; prevalence; procedure; process; production; quality; quality blood; range; rate; rbc blood; rbc transfusion; rbcs; reactive; red; reduced; repeat donors; research; results; rhd; rhd blood; risk; routine; screening; selection; sequencing; serum; significant; specific; staff; standard; status; storage; studies; study; summary; surgery; systems; tested; testing; tests; therapy; time donors; total; transfusion medicine; transfusion reactions; transfusion safety; transfusion service; transfusion therapy; transfusions; treated; treatment; typing; use; value; variant; versus; weak; women; years cache: cord-010092-uftc8inx.txt plain text: cord-010092-uftc8inx.txt item: #207 of 2876 id: cord-010116-hfzs16jh author: Díaz‐Ravetllat, V. title: Significance of new lung infiltrates in outpatients after lung and heart–lung transplantation date: 2014-04-12 words: 4261 flesch: 34 summary: Acute and chronic phases Standardisation of spirometry Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria Definition and classification of community-acquired and nosocomial pneumonias Manual of Clinical Microbiology Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group European Respiratory Monograph: Respiratory Emergencies Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection Impact of graft colonization with gram-negative bacteria after lung transplantation on the development of bronchiolitis obliterans syndrome in recipients with cystic fibrosis Imaging of the chest after lung transplantation Pneumonia after lung transplantation in the RESITRA Cohort: a multicenter prospective study Infections relevant to lung transplantation Pulmonary infections diagnosed by BAL: a 12-year experience in 1066 immunocompromised patients Aspergillus infection in lung transplant patients: incidence and prognosis Circulating and intrapulmonary C-reactive protein: a predictor of bronchiolitis obliterans syndrome and pulmonary allograft outcome Pseudomonas aeruginosa colonization of the allograft after lung transplantation and the risk of bronchiolitis obliterans syndrome Community-acquired respiratory viral infections in lung transplant recipients: a single season cohort study Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunction Reimplantation lesion in the postoperative period of lung transplantation. key: cord-010116-hfzs16jh authors: Díaz‐Ravetllat, V.; Greer, M.; Haverich, A.; Warnecke, G.; Dierich, M.; Welte, T.; Gottlieb, J. title: Significance of new lung infiltrates in outpatients after lung and heart–lung transplantation date: 2014-04-12 journal: Transpl Infect Dis DOI: 10.1111/tid.12209 sha: doc_id: 10116 cord_uid: hfzs16jh BACKGROUND: Infection and rejection represent major complications following lung transplantation and are often associated with pulmonary infiltrates. keywords: clad; diagnosis; infection; infiltrates; lung; patients; pulmonary; rejection; study; transplantation cache: cord-010116-hfzs16jh.txt plain text: cord-010116-hfzs16jh.txt item: #208 of 2876 id: cord-010119-t1x9gknd author: None title: Abstract Presentations from the AABB Annual Meeting San Diego, CA ctober 7‐10, 2017 date: 2017-09-04 words: 230433 flesch: 50 summary: Probability of occurrence of cannabis metabolites in blood donor samples is likely to be highly variable across donor centers and is largely dependent on blood donor demographics. OBRR, CBER, FDA Background/Case Studies: Extended molecular typing of a large number of blood donors can increase the likelihood of identifying donor red blood cells (RBCs) that match those of the recipient. keywords: abo; abo blood; acute; addition; alleles; alloimmunization; analysis; anemia; anti; antibodies; antibody; antigen; apheresis; approach; assay; average; background; bacterial; blood; blood bank; blood cells; blood center; blood collection; blood components; blood count; blood donation; blood donors; blood group; blood loss; blood management; blood order; blood ordering; blood products; blood safety; blood samples; blood screening; blood services; blood specimens; blood supplier; blood supply; blood system; blood testing; blood transfusion; blood type; blood units; blood volume; care; case studies; case study; cases; cd36; cell transfusion; center background; centers; change; clinical; collections; concentration; conclusion; control; cord blood; cost; count; cross; culture; current; data; days; decreased; detection; difference; disease; dna; donations; donor samples; dose; dtt; effect; emergency blood; evaluation; events; evidence; expression; factors; fda; female; ffp; finding; flow; following; frequency; fresh; gel; gene; genotyping; given; groups; hbv; hcv; health; hemoglobin; hemolysis; high; history; hiv; hla; hospital; hospital blood; hospital transfusion; hours; human; identification; igg; immucor; impact; implementation; improvement; incidence; increase; infection; information; initial; institution; inventory; iron; laboratory; levels; low; manual; mean; median; medical; method; mice; minutes; model; molecular; months; mtp; need; negative; new; non; normal; number; order; partial; pathogen; patients; pcr; performance; period; phase; phenotype; plasma; plasma samples; plasma transfusion; plasma units; platelet; platelet blood; platelet transfusion; platelet units; plt; plts; population; positive; post; post transfusion; potential; practice; pre; presence; present; prevalence; procedure; process; processing; program; protocol; quality; r blood; range; rate; rbc; rbc blood; rbc transfusion; rbc units; rbcs; reactive; reactivity; reagent; recipients; recovery; red; reduced; reduction; reference; report; response; results; review; rhd; risk; routine; screening; second; sensitivity; sequencing; serum; set; small; solution; specific; specificity; staff; standard; storage; study design; study period; survey; systems; table; technology; test results; testing; tests; therapy; time; titer; total; tpe; training; transfused; transfusion medicine; transfusion practice; transfusion protocol; transfusion reactions; transfusion results; transfusion service; transfusions; trauma; treatment; tube; typing; units; university; use; values; virus; wastage; wbc; weak; weeks; women; year; zika; zikv cache: cord-010119-t1x9gknd.txt plain text: cord-010119-t1x9gknd.txt item: #209 of 2876 id: cord-010141-955r29sd author: Sibila, Oriol title: Nonantibiotic Adjunctive Therapies for Community-Acquired Pneumonia (Corticosteroids and Beyond): Where Are We with Them? date: 2016-12-17 words: 4025 flesch: 28 summary: Intensive Prior statin therapy is associated with a decreased rate of severe sepsis Statin treatment after onset of sepsis in a murine model improves survival Unexpected antimicrobial effect of statins Statin treatment and reduced risk of pneumonia in patients with diabetes Statin use and clinical outcomes among pneumonia patients Increased statin prescribing does not lower pneumonia risk Effect of pravastatin on the frequency of ventilator-associated pneumonia and on intensive care unit mortality: open-label, randomized study Effect of statin therapy on mortality in patients with ventilatorassociated pneumonia: a randomized clinical trial The effect of simvastatin on inflammatory cytokines in community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock Gammaglobulin levels in patients with community-acquired septic shock Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia Bench-to-bedside review: immunoglobulin therapy for sepsisbiological plausibility from a critical care perspective Score-Based Immunoglobulin Therapy of Sepsis (SBITS) Study Group. In a model of severe pneumonia in mechanically ventilated piglets, we observed lower lung cytokine concentrations and less lung bacterial burden in piglets that were treated with corticosteroids plus antibiotic compared with those treated only with antibiotics. keywords: cap; community; corticosteroids; mortality; patients; pneumonia; studies; study; treatment cache: cord-010141-955r29sd.txt plain text: cord-010141-955r29sd.txt item: #210 of 2876 id: cord-010261-sy7esszi author: Tenenbein, Milton title: Early coagulopathy in severe iron poisoning date: 2006-08-17 words: 1335 flesch: 41 summary: Patient 1 had a subsequent improvement in hemostasis with a fall in serum iron concentration. The coagulation measurements in patient 1 also improved coincident with a precipitous fall in serum iron concentration and prior to the onset of the hepatic coagulopathy. keywords: coagulation; coagulopathy; iron; patients cache: cord-010261-sy7esszi.txt plain text: cord-010261-sy7esszi.txt item: #211 of 2876 id: cord-010398-5wot7tix author: Clauw, Daniel J. title: Perspectives on Fatigue from the Study of Chronic Fatigue Syndrome and Related Conditions date: 2010-05-31 words: 10757 flesch: 34 summary: A meta-analysis and systematic review of methodological quality of heart rate variability studies in functional somatic disorders Epidemiology of chronic musculoskeletal pain Resistance exercise training improves heart rate variability in women with fibromyalgia POTS versus deconditioning: The same or different? Chronic fatigue syndrome: Illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function Chronic widespread pain and its comorbidities: A population-based study Importance of genetic influences on chronic widespread pain Coping strategies in twins with chronic fatigue and chronic fatigue syndrome A twin study of posttraumatic stress disorder symptoms and chronic widespread pain Power spectral analysis of sleep EEG in twins discordant for chronic fatigue syndrome The Chronic Fatigue Twin Registry: Method of construction, composition, and zygosity assignment Twin analyses of fatigue A review of its pharmacological properties and therapeutic use in chronic pain states Long-term results of amitriptyline treatment for interstitial cystitis Antidepressants as analgesics: A review of randomized controlled trials Duloxetine and other antidepressants in the treatment of patients with fibromyalgia Gabapentin in the treatment of fibromyalgia: A randomized, double-blind, placebocontrolled, multicenter trial A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder Duloxetine for the treatment of fibromyalgia in women: Pooled results from two randomized, placebo-controlled clinical trials Management of musculoskeletal pain Exercise in the prevention and treatment of chronic disorders Cognitive and behavioral approaches to chronic pain Physiological cost of walking in those with chronic fatigue syndrome (CFS): A case-control study Chronic fatigue syndrome: An approach combining self-management with graded exercise to avoid exacerbations Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects Evidence from a national birth cohort study Premorbid personality in chronic fatigue syndrome as determined by the Temperament and Character Inventory Does depression mediate the relation between fatigue severity and disability in chronic fatigue syndrome sufferers? Postinfectious chronic fatigue: A distinct syndrome? keywords: cfs; chronic; conditions; control; exercise; fatigue; fatigue syndrome; fibromyalgia; pain; patients; sleep; stress; studies; study; symptoms; syndrome cache: cord-010398-5wot7tix.txt plain text: cord-010398-5wot7tix.txt item: #212 of 2876 id: cord-010416-u0yo0lk6 author: Tejada, Sofia title: Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials date: 2020-04-28 words: 4011 flesch: 32 summary: Cochrane Database Syst Rev Cochrane Handbook for Systematic Reviews of Interventions Version 5 Estimating the mean and variance from the median, range, and the size of a sample A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza A and B infections Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial A clinical trial of intravenous peramivir compared with oral oseltamivir for the treatment of seasonal influenza in hospitalized adults Virological response to peramivir treatment in adults hospitalised for influenza-associated lower respiratory tract infections Intravenous peramivir for treatment of influenza A and B virus infection in high-risk patients Intravenous peramivir for treatment of influenza in hospitalized patients Comparison of efficacy of intravenous peramivir and oral oseltamivir for the treatment of influenza: systematic review and meta-analysis Safety and effectiveness of neuraminidase inhibitors for influenza treatment, prophylaxis, and outbreak control: a systematic review of systematic reviews and/or meta-analyses Safety and effectiveness of neuraminidase inhibitors in situations of pandemic and/or novel/variant influenza: a systematic review of the literature, 2009-15 Impact of neuraminidase inhibitor treatment on outcomes of public health importance during the 2009-2010 influenza A(H1N1) pandemic: a systematic review and metaanalysis in hospitalized patients Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a metaanalysis of individual participant data The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza Clinical outcomes of patients treated with intravenous zanamivir for severe influenza A(H1N1)pdm09 infection: a case report series Severe myocarditis due to influenza A(H1N1)pdm09 viral infection in a young woman successfully treated with intravenous zanamivir: a case report CS-8958: long-acting neuraminidase inhibitors for the treatment of influenza Influenza virus polymerase inhibitors in clinical development Phase 3 trial of baloxavir marboxil in high-risk influenza patients (CAP-STONE-2 study) While there is a consensus on dosing and duration of treatment for outpatients and high-risk population, management of influenza treatment in hospitalized and severely ill patients is suboptimal. keywords: influenza; oseltamivir; patients; regimens; studies; therapy; treatment; trials cache: cord-010416-u0yo0lk6.txt plain text: cord-010416-u0yo0lk6.txt item: #213 of 2876 id: cord-010460-pczs9alv author: Caruso, Thomas J. title: Retrospective Review of the Safety and Efficacy of Virtual Reality in a Pediatric Hospital date: 2020-04-10 words: 3807 flesch: 39 summary: CCLS were additionally trained by the physician Chariot Program Manager to assess potential adverse events during VR interventions. Our findings examining the efficacy of VR interventions are exploratory, and the present study was not powered to compare the effectiveness of VR to existing interventions. keywords: ccls; cooperation; intervention; patients; reality; study cache: cord-010460-pczs9alv.txt plain text: cord-010460-pczs9alv.txt item: #214 of 2876 id: cord-010461-un9pls28 author: Manohar, Sujal title: A Three-part Quality Improvement Initiative to Increase Patient Satisfaction and Reduce Appointment Time date: 2020-03-09 words: 3197 flesch: 51 summary: There was no difference in appointment lengths between Hispanic/Latino patients and other patients, and an encouraging finding that suggests PediPlace providers are effective bilingual communicators. This quality improvement (QI) project aimed to reduce appointment lengths and improve the patient experience. keywords: appointment; clinic; patient; pediplace; provider; time cache: cord-010461-un9pls28.txt plain text: cord-010461-un9pls28.txt item: #215 of 2876 id: cord-010477-g754gjvh author: Carney, Kevin P. title: A Front-end Redesign With Implementation of a Novel “Intake” System to Improve Patient Flow in a Pediatric Emergency Department date: 2020-02-27 words: 3746 flesch: 45 summary: The American Academy of Pediatrics also recognizes this as a particular problem affecting the care of pediatric patients in the ED and in 2015 published a report outlining best practices for patient flow and care for these patients. A key driver of ED patient flow is its front-end system, consisting of all the operational steps that occur before a provider sees the patient. keywords: emergency; end; flow; patient; provider; system; team cache: cord-010477-g754gjvh.txt plain text: cord-010477-g754gjvh.txt item: #216 of 2876 id: cord-010487-wncgecld author: Rinella, Mary E. title: STELLAR 3 and STELLAR 4: Lessons From the Fall of Icarus date: 2020-04-30 words: 1412 flesch: 41 summary: In the absence of a placebo controlled phase 2b study, STELLAR 3 and 4 were substantially informed by a phase 2 study, [5] in which NASH patients with F2/F3 were recruited in a multicenter trial and randomized in a 2:2:1:1:1 ratio to receive 24 weeks of treatment with 6 mg or 18 mg of selonsertib alone; 6 mg or 18 mg of selonsertib with 125 mg of simtuzumab; or 125 mg of simtuzumab alone. The STELLAR studies did not meet their primary outcomes, and selonsertib was ineffective in reversing fibrosis in NASH patients with stage F3 and F4 fibrosis -those most in need of treatment. keywords: fibrosis; nash; patients; phase cache: cord-010487-wncgecld.txt plain text: cord-010487-wncgecld.txt item: #217 of 2876 id: cord-010564-7c9h16bi author: Unolt, Marta title: Pathogenic variants in CDC45 on the remaining allele in patients with a chromosome 22q11.2 deletion result in a novel autosomal recessive condition date: 2019-09-02 words: 4689 flesch: 38 summary: Here we identified CDC45 variants in a cohort of patients with a 22q11.2 deletion and craniosynostosis and/or other atypical developmental anomalies. To screen seven more patients (Table S1 ) with a combination of 22q11.2 deletion and rare CDC45 variants, CDC45 exons, splice sites, and untranslated regions were sequenced. keywords: anomalies; cdc45; craniosynostosis; deletion; features; findings; gene; patients; syndrome; table; variants cache: cord-010564-7c9h16bi.txt plain text: cord-010564-7c9h16bi.txt item: #218 of 2876 id: cord-010566-tciwtxud author: Singh, Nina title: Outcome of patients with cirrhosis requiring intensive care unit support: Prospective assessment of predictors of mortality date: 1998 words: 3674 flesch: 34 summary: 35 Mental status has been shown to be a significant predictor of outcome in ICU patients in a number of clinical settings, e.g., patients with acute renal failure requiring dialysis and transplant recipients. 9,10 Acute physiology and chronic health evaluation (APACHE) scores were determined to be of prognostic significance in a study in ICU patients with cirrhosis; however, neither Child-Pugh scores nor etiology of liver disease were assessed in that study. keywords: cirrhosis; icu; liver; mortality; patients; scores cache: cord-010566-tciwtxud.txt plain text: cord-010566-tciwtxud.txt item: #219 of 2876 id: cord-010658-67k8pthy author: Bernard, Andie title: PC-FACS May 2020 for July 2020 Issue date: 2020-05-07 words: 1927 flesch: 39 summary: Furthermore, nonbeneficial/unwanted care puts other patients, family, and healthcare workers at greater transmission risk. As of March 17, mortality was 67%, 24% of patients have remained critically ill, and 9.5% have been discharged from the ICU. keywords: care; covid-19; families; pandemic; patients cache: cord-010658-67k8pthy.txt plain text: cord-010658-67k8pthy.txt item: #220 of 2876 id: cord-010786-w3kjc6so author: Ghaderi, Sara title: Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway date: 2019-12-23 words: 3527 flesch: 35 summary: We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. The IRR for emergency hospitalization among MS patients the first week after an influenza diagnosis was 3.4 (95% CI 2.4–4.8). keywords: hospitalization; influenza; pandemic; patients; risk; study cache: cord-010786-w3kjc6so.txt plain text: cord-010786-w3kjc6so.txt item: #221 of 2876 id: cord-010844-y26y5myb author: Lessing, Noah L. title: Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why? date: 2020-04-29 words: 4443 flesch: 44 summary: To better quantify the landscape of spinal trauma in LMICs, we sought to study a cohort of nonoperative TSI patients through the following objectives: (1) describe the population of nonoperative patients, (2) compare outcomes of patients managed nonoperatively to those undergoing surgery, and (3) discern risk factors for receiving nonoperative care. CONCLUSIONS: Eighty-six percent of nonoperative TSI patients had an indication for surgery. keywords: cord; injuries; injury; nonoperative; patients; spinal; surgery; tsi cache: cord-010844-y26y5myb.txt plain text: cord-010844-y26y5myb.txt item: #222 of 2876 id: cord-010856-3g0123lk author: Araghi, Ariyan S. title: An audit to analyse the two-week wait pathway at an oral cancer specialist district general hospital date: 2020-05-08 words: 5115 flesch: 57 summary: It brings the reader's attention to upcoming changes to the timeframe in which oral cancer patients must be seen, diagnosed and treated as per the NHS Long Term Plan (2020). This has already been tackled in part by the development of a new model for simplifying the management of oral cancer patients. keywords: 2ww; audit; cancer; days; diagnosis; neck; patients; referral cache: cord-010856-3g0123lk.txt plain text: cord-010856-3g0123lk.txt item: #223 of 2876 id: cord-010921-yzv43e8l author: Kaye, Alan David title: Dexmedetomidine in Enhanced Recovery After Surgery (ERAS) Protocols for Postoperative Pain date: 2020-04-02 words: 7269 flesch: 40 summary: Thus, use of alpha-2 agonists decreases the sympathetic outflow and counteracts the physiological effects, but the clear mechanism of dexmedetomidine effects is still unclear. In 2008, the FDA approved dexmedetomidine use for procedural sedation and for sedation in non-intubated patients. keywords: analgesia; analysis; anesthesia; dexmedetomidine; dose; effects; mcg; opioid; pain; patients; surgery; use cache: cord-010921-yzv43e8l.txt plain text: cord-010921-yzv43e8l.txt item: #224 of 2876 id: cord-010929-d598h08w author: Kashiwagi, Hirokazu title: Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision date: 2020-01-02 words: 11824 flesch: 36 summary: Results of a French observational study Sustained remission of chronic immune thrombocytopenia after discontinuation of treatment with thrombopoietin-receptor agonists in adults Successful discontinuation of eltrombopag after complete remission in patients with primary immune thrombocytopenia Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents Induction of immune tolerance to platelet antigen by short-term thrombopoietin treatment in a mouse model of immune thrombocytopenia Thrombopoietin-induced signal transduction and potentiation of platelet activation Thromboembolic events among adult patients with primary immune thrombocytopenia in the United Kingdom General Practice Research Database Risk of arterial thrombosis in patients with primary chronic immune thrombocytopenia: a Danish populationbased cohort study Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study Evaluation of bone marrow reticulin in patients with chronic immune thrombocytopenia treated with eltrombopag: data from the EXTEND study Bone marrow fibrosis in 66 patients with immune thrombocytopenia treated with thrombopoietin-receptor agonists: a single-center, long-term follow-up Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia Long-term follow-up for up to 5 years on the risk of leukaemic progression in thrombocytopenic patients with lower-risk myelodysplastic syndromes treated with romiplostim or placebo in a randomised double-blind trial Association between acute myelogenous leukemia and thrombopoietin receptor agonists in patients with immune thrombocytopenia Toxicities of the thrombopoietic growth factors Eltrombopag versus romiplostim in treatment of adult patients with immune thrombocytopenia: a systematic review incorporating an indirect-comparison metaanalysis A retrospective pilot evaluation of switching thrombopoietic receptor-agonists in immune thrombocytopenia Use of eltrombopag after romiplostim in primary immune thrombocytopenia Thrombopoietin receptor agonist switch in adult primary immune thrombocytopenia patients: a retrospective collaborative survey involving 4 Spanish centres Alternate use of thrombopoietin receptor agonists in adult primary immune thrombocytopenia patients: a retrospective collaborative survey from Italian hematology centers Rituximab plus standard of care for treatment of primary immune thrombocytopenia: a systematic review and meta-analysis Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia A pilot randomized trial of adjuvant rituximab or placebo for nonsplenectomized patients with immune thrombocytopenia Low-dose rituximab combined with short-term glucocorticoids up-regulates Treg cell levels in patients with immune thrombocytopenia Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial Efficacy and safety of rituximab in Japanese patients with relapsed chronic immune thrombocytopenia refractory to conventional therapy Rituximab therapy for chronic and refractory immune thrombocytopenic purpura: a long-term follow-up analysis Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura: results of a prospective multicenter phase 2 study Multi-center randomized open label phase II trial on three rituximab dosing schemes in immune thrombocytopenia patients Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia Rituximab in immune thrombocytopenia: gender, age, and response as predictors of long-term response Rituximab before splenectomy in adults with primary idiopathic thrombocytopenic purpura: a meta-analysis Repeated courses of rituximab in chronic ITP: Three different regimens Safety and efficacy of rituximab in adult immune thrombocytopenia: results from a prospective registry including 248 patients Gender and duration of disease differentiate responses to rituximab-dexamethasone therapy in adults with immune thrombocytopenia The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura The effect of rituximab on anti-platelet autoantibody levels in patients with immune thrombocytopenia Lack of detectable platelet autoantibodies is correlated with nonresponsiveness to rituximab treatment in ITP patients GPIIb/IIIa autoantibody predicts better rituximab response in ITP Rituximab in autoimmune haemolytic anaemia and immune thrombocytopenic purpura: a Belgian retrospective multicentric study Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project Case records of the Massachusetts General Hospital. Pulse cyclophosphamide therapy for refractory autoimmune thrombocytopenic purpura Dapsone for primary immune thrombocytopenia in adults and children: an evidence-based review Dapsone therapy for refractory immune thrombocytopenia patients: a case series Disappointing response to dapsone as second line therapy for primary ITP: a case series Danazol for the treatment of idiopathic thrombocytopenic purpura keywords: bleeding; cases; chronic; count; dose; efficacy; immune; itp; patients; platelet; platelet count; purpura; rituximab; splenectomy; therapy; thrombocytopenia; treatment cache: cord-010929-d598h08w.txt plain text: cord-010929-d598h08w.txt item: #225 of 2876 id: cord-010933-xuztu95a author: Davis, Samuel title: Theoretical bounds and approximation of the probability mass function of future hospital bed demand date: 2018-11-06 words: 5990 flesch: 42 summary: Let γ group d t ð Þ represent the forecasted random variable of demand at period t made from period d for a given patient group, where group ∈ { curr, sch, emer, nysched}, representing current patients, scheduled patients, emergency patients, and not-yet-scheduled patients, respectively. Applying the forecasting model to a hospital that predominantly sees scheduled patients relative to emergency patients could significantly reduce the MAE of the predictions. keywords: demand; distribution; emergency; forecast; hospital; los; mean; model; patients; period; variable cache: cord-010933-xuztu95a.txt plain text: cord-010933-xuztu95a.txt item: #226 of 2876 id: cord-010980-sizuef1v author: None title: ECTES Abstracts 2020 date: 2020-05-11 words: 132805 flesch: 50 summary: Investigation of coagulopathies and its relevance with mortality and transfusion rates using thromboelastography in trauma patients Introduction: Inter-hospital variation in surgical intensity for trauma admissions: a multicenter cohort study L. Moore 1 , M. P. Patton 2 , I. Farhat 2 , P. A. Tardif 2 , C. Gonthier 3 , A. Belcaid 3 , F. Lauzier 2 , A. Turgeon 2 , J. Clément 2 1 Université Laval, Social and preventive medicine, québec, Canada, 2 CHU de Québec-Université-Laval, Québec, Canada, 3 Introduction: Guidelines for trauma patients are increasingly moving away from surgical management towards less invasive procedures but there is a knowledge gap on how these recommendations are influencing practice. keywords: 0.001; abdomen; abdominal; acute; admission; adult patients; age; aim; analysis; approach; average; bleeding; blood; blunt; bone; brain; cases; cause; chest; clinical; cohort; cohort study; comments; complications; conclusions; control; data; days; death; department; diagnosis; emergency; emergency surgery; factors; findings; fixation; follow; following; fractures; general; good; grade; group; head; hip; history; hospital; hospital mortality; icu; incidence; increased; injuries; injury; injury severity; introduction; investigation; iss; laparotomy; left; level; literature; male; management; material; mean; mechanism; median; medical; methods; model; months; mortality; mortality rate; neck; need; non; number; open; operative; outcomes; p =; pain; patients c; patients introduction; pelvic; period; plate; polytrauma patients; population; postoperative; pressure; primary; procedure; progressions; range; rate; reduction; results; review; right; risk; scan; score; screw; severity; shock; stay; studies; study; study introduction; surgeons; surgery; surgery patients; survival; system; technique; test; therapy; time; tissue; total; transfusion; trauma care; trauma center; trauma patients; trauma registry; trauma surgery; trauma team; treatment; type; university; use; vascular; wound; years cache: cord-010980-sizuef1v.txt plain text: cord-010980-sizuef1v.txt item: #227 of 2876 id: cord-010999-u2guhh3h author: Blackstone, Eric title: Making Medical Decisions for Incapacitated Patients Without Proxies: Part II date: 2019-11-06 words: 6596 flesch: 49 summary: The role of a hospital ethics consultation service in decision-making for unrepresented patients Who should decide for the unrepresented? Advance directives as acts of communication: A randomized controlled trial Shared decision making: A model for clinical practice Projection in surrogate decisions about life-sustaining medical treatments Making medical decisions for incapacitated patients without proxies: Part I When patients do not have a proxy: A procedure for medical decision making when there is no one to speak for the patient Victims of groupthink Medical decision-making for adults who lack decision-making capacity and a surrogate: State of the science Unbefriended and unrepresented: Better medical decision making for incapacitated patients without healthcare surrogates Recovery from musculoskeletal injury: The role of social support following a transport accident Medical decision making for patients without proxies: The effect of personal experience in the deliberative process Ethical and legal considerations in the management of an unbefriended patient in a vegetative state Evidence from a large sample on the effects of group size and decision-making time on performance in a marketing simulation game Decisions to limit life-sustaining treatment for critically ill patients who lack both decision-making capacity and surrogate decision-makers Life support for patients without a surrogate decision maker: Who decides? Ethical challenge: When clinicians act as surrogates for unrepresented patients McAliley for assisting with the interviews, and the PWP committee volunteers. Absent any clues as to the patient's preferences, who should make medical decisions? keywords: committee; committee members; decision; ethics; making; members; patient; pwp; team cache: cord-010999-u2guhh3h.txt plain text: cord-010999-u2guhh3h.txt item: #228 of 2876 id: cord-011062-ukz4hnmy author: None title: Poster date: 2020-03-11 words: 88442 flesch: 49 summary: Greater grip strength was associated with lower % of body fat and higher % of muscle mass. Conclusion: Older adult patients hospitalized for hip fracture who had frailty, functional dependence, and social problems had significant adverse events at a general hospital in Lima, Peru. keywords: activities; activity; adults; age; aging; analysis; assessment; association; background; baseline; bmi; body; care; cognitive; cohort; community; conclusion; criteria; cross; daily; data; day; decline; differences; disability; disease; dwelling; effect; elderly; exercise; factors; falls; fat; follow; frailty; frailty index; frailty screening; frailty status; function; gait; geriatric; grip; grip strength; group; health; high; hospital; impairment; increase; individuals; intake; intervention; level; life; living; loss; low; mean; measures; methods; model; months; mortality; muscle; muscle function; muscle health; muscle mass; muscle strength; non; obesity; objectives; outcomes; p<0.001; participants; patients; people; performance; physical; population; prevalence; program; protein; quality; regression; results; risk; sample; sarcopenia; score; screening; sex; speed; sppb; studies; study; subjects; surgery; test; time; total; training; university; vs.; walking; weight; women; years cache: cord-011062-ukz4hnmy.txt plain text: cord-011062-ukz4hnmy.txt item: #229 of 2876 id: cord-011093-d9dbvbcy author: Orange, Jordan S. title: How I Manage Natural Killer Cell Deficiency date: 2019-11-22 words: 8257 flesch: 41 summary: key: cord-011093-d9dbvbcy authors: Orange, Jordan S. title: How I Manage Natural Killer Cell Deficiency date: 2019-11-22 journal: J Clin Immunol DOI: 10.1007/s10875-019-00711-7 sha: doc_id: 11093 cord_uid: d9dbvbcy Natural killer (NK) cell deficiency (NKD) is a subset of primary immunodeficiency disorders (PID) in which an abnormality of NK cells represents a major immunological defect resulting in the patient’s clinical immunodeficiency. This is supported by strong evidence accumulated in a wide variety of animal models and in select human contexts collected over the nearly 45 years since NK cells were named as such. keywords: cell; cytotoxicity; deficiency; function; genes; immunodeficiency; killer; nk cell; nkd; number; patients; pid cache: cord-011093-d9dbvbcy.txt plain text: cord-011093-d9dbvbcy.txt item: #230 of 2876 id: cord-011103-sstpidvk author: Younan, Duraid title: Factors Predictive of Ventilator-associated Pneumonia in Critically Ill Trauma Patients date: 2019-11-26 words: 2392 flesch: 41 summary: Toward improved surveillance: the impact of ventilator-associated complications on length of stay and antibiotic use in patients in intensive care units The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated Review article: ventilator-associated pneumonia in major burns Early tracheostomy in trauma patients saves time and money Risk and prognostic factors of ventilator-associated pneumonia in trauma patients Prevention of ventilator-associated pneumonia: the multimodal approach of the Spanish ICU 'pneumonia zero' program Sustained reduction of ventilator-associated pneumonia rates using real-time course correction with a ventilator bundle compliance dashboard Preventing ventilator-associated infections Ventilator-associated pneumonia is more common and of less consequence in trauma patients compared with other critically ill patients Early trauma-induced coagulopathy is associated with increased ventilator-associated pneumonia in spinal cord injury patients Risk factors for ventilator-associated pneumonia in trauma patients: a descriptive analysis Early bronchoalveolar lavage for intubated trauma patients with TBI or chest trauma Predictors of pulmonary complications in blunt traumatic spinal cord injury Early tracheostomy in patients with traumatic cervical spinal cord injury appears safe and may improve outcomes Incidence and risk factors for the development of acute renal failure in patients with ventilatorassociated pneumonia Fluid overload and kidney injury score as a predictor for ventilator-associated events Pre-intensive care unit intubation and subsequent delayed intensive care unit admission is independently associated with increased occurrence of ventilator-associated pneumonia Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients Among critically ill trauma patients, acute kidney injury, injury to the spine, face or sternum, massive transfusion and intensive care unit length of stay were associated with VAP. Ventilator-associated pneumonia (VAP) is the most common nosocomial infection among trauma patients requiring prolonged mechanical ventilation [1] ; it is associated with prolonged mechanical ventilation, intensive care unit stay and hospital length of stay [2] . keywords: injury; patients; trauma; vap cache: cord-011103-sstpidvk.txt plain text: cord-011103-sstpidvk.txt item: #231 of 2876 id: cord-011138-y9v5ivzg author: Hatchimonji, Justin S. title: Questioning dogma: does a GCS of 8 require intubation? date: 2020-05-07 words: 3235 flesch: 48 summary: Given the lack of strong evidentiary support for intubating patients for a GCS of 8 or less, we sought to investigate the treatment effect of intubation in trauma patients with a GCS less than 8 using a nationally representative database. Ventilation, respiratory system NEC, invasive per orifice approach by endotracheal intubation, manual hand assisted 1GZ31CAND (ICD-10-CA/CCI) Ventilation, respiratory system NEC, invasive per orifice approach by endotracheal intubation, positive pressure American College of Surgeons Guidelines for emergency tracheal intubation immediately after traumatic injury Emergency tracheal intubation immediately following traumatic injury: An Eastern Association for the Surgery of Trauma practice management guideline Early intubation in the management of trauma patients: indications and outcomes in 1,000 consecutive patients Trauma patients with prehospital Glasgow Coma Scale less than nine: not a homogenous group A tale of two cities: prehospital intubation with or without paralysing agents for traumatic brain injury National Trauma Data Bank (NTDB) Influence of the National Trauma Data Bank on the study of trauma outcomes: is it time to set research best practices to further enhance its impact? keywords: analysis; gcs; intubation; mortality; patients; trauma cache: cord-011138-y9v5ivzg.txt plain text: cord-011138-y9v5ivzg.txt item: #232 of 2876 id: cord-011159-k2kca8zl author: Kamel, Toufik title: Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study date: 2020-01-07 words: 5116 flesch: 40 summary: BAL respiratory tolerance was first assessed by recording the need for modification(s) in respiratory support as previously described [8] from the beginning of bronchoscopy to 24 h after, including need of tracheal intubation, increase by more than 50% in oxygen flow rate, or use of HFNC in patients under standard oxygen therapy, increase by more than 20% in gas flow rate or FiO 2 in patients initially under HFNC, need of non-invasive ventilation (NIV) in patients who initially had no mechanical respiratory support and increase by more than 20% in inspiratory pressure support or in positive end-expiratory pressure or in FiO 2 , in patients initially treated by NIV. Patients were included if (1) they had an indication to undergo a BAL as decided by their attending intensivist, (2) cellular analysis of BAL fluid by a pathologist was planned, and (3) consent had been obtained. keywords: bal; bronchoscopy; events; fluid; non; oxygen; patients; physician; study cache: cord-011159-k2kca8zl.txt plain text: cord-011159-k2kca8zl.txt item: #233 of 2876 id: cord-011181-9nvwk04v author: Jakimovska, Vesna Miloshevska title: Epidemiological characteristics and early complications after spinal cord injury in Former Yugoslav Republic of Macedonia date: 2019-08-19 words: 5368 flesch: 49 summary: Rahimi-Movaghar V. Incidence of traumatic spinal cord injury worldwide: a systematic review Recent trends in mortality and causes of death among persons with spinal cord injury International standards for neurological classification of spinal cord injury (revised International Spinal Cord Injury Core Data Set Standardization of data analysis and reporting of results from the International Spinal Cord Injury Core Data Set International spinal cord injury spinal column injury basic data set International spinal cord injury: spinal interventions and surgical procedures basic data set International spinal cord injury skin and thermoregulation function basic data set Version 1.1 of the international spinal cord injury skin and thermoregulation function basic data set Recommendations for translation and reliability testing of International Spinal Cord Injury Data Sets A comparison of life threatening injury concept in the Turkish Penal Code and trauma scoring systems The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) International Spinal Cord Injury Core Data Set (version 2.0)-including standardization of reporting Incidence of traumatic spinal cord injury in Thessaloniki Traumatic spinal cord injury in the north-east Tanzania-describing incidence, etiology and clinical outcomes retrospectively Changing demographics of spinal cord injury over a 20-year period: a longitudinal population-based study in Scotland Traumatic Spinal Injuries in Northern Finland Incidence of traumatic spinal cord injury in Italy during 2013-2014: a population-based study Fall-induced spinal cord injury: external causes and implications for prevention Traumatic spinal cord injury in Tianjin, China: a single-center report of 354 cases Epidemiology of sport-related spinal cord injuries: a systematic review Risk factors and prevention for spinal cord injury from diving in swimming pools and natural sites in Quebec, Canada: a 44-year study Update on critical care for acute spinal cord injury in the setting of polytrauma Acute management of traumatic spinal cord injury in a Greek and a Swedish region: a prospective, population-based study Prevalence of secondary medical complications and risk factors for pressure ulcers after traumatic spinal cord injury during acute care in South Africa Prevalence, location, grade of pressure ulcers and association with specific patient characteristics in adult spinal cord injury patients during the hospital stay: a prospective cohort study Pressure ulcer risk factors in persons with SCI: Part I: acute and rehabilitation stages Urinary tract infections in special populations: diabetes, renal transplant, HIV infection, and spinal cord injury Complications following spinal cord injury: occurrence and risk factors in a longitudinal study during and after inpatient rehabilitation Complications during the acute phase of traumatic spinal cord lesions Supine position and nonmodifiable risk factors for ventilator-associated pneumonia in trauma patients Previously identified common post-injury adverse events in traumatic spinal cord injury-validation of existing literature and relation to selected potentially modifiable comorbidities: a prospective Canadian cohort study Acute complications of spinal cord injuries Critical care of traumatic spinal cord injury Mortality due to traumatic spinal cord injuries in Europe: a cross-sectional and pooled analysis of population-wide data from 22 countries Late mortality during the first year after acute traumatic spinal cord injury: a prospective, population-based study Spinal cord injury after traumatic spine fracture in patients with ankylosing spinal disorders Acknowledgements We want to thank the study participants, the Sunnaas Rehabilitation Hospital, and the QUOTA program for contributing with financial support to the project. The first author contacted colleagues, orthopedic surgeons, at Orthopedic hospital St.Erasmo-Ohrid (they treat scoliosis and vertebral fractures/dislocations without SCI), and the other hospital that has orthopedic ward in Skopje, named 8th of September, and they both confirmed that they do not treat SCI patients. keywords: complications; cord; data; hospital; injury; mortality; patients; sci; spinal; study; years cache: cord-011181-9nvwk04v.txt plain text: cord-011181-9nvwk04v.txt item: #234 of 2876 id: cord-011188-59hn9wsv author: Bruce, Lori title: A Pot Ignored Boils On: Sustained Calls for Explicit Consent of Intimate Medical Exams date: 2020-03-09 words: 8933 flesch: 40 summary: [patients' right to refuse student exams] takes on heightened sensitivity (Cohen et al. 1988) . UIEs are found to contribute to moral erosion and moral distress of medical students and compromise the sacred trust between the medical community and the general public. keywords: consent; ethics; exams; institutions; medical; patient; pelvic; physicians; students; training; uies; women cache: cord-011188-59hn9wsv.txt plain text: cord-011188-59hn9wsv.txt item: #235 of 2876 id: cord-011221-rhyxp4v5 author: Fu, Chih-Yuan title: Obesity is Associated with Worse Outcomes Among Abdominal Trauma Patients Undergoing Laparotomy: A Propensity-Matched Nationwide Cohort Study date: 2019-11-11 words: 2499 flesch: 40 summary: Obesity is associated with increased morbidity and mortality in abdominal trauma patients. The characteristics of abdominal trauma patients with poor outcomes related to obesity require evaluation. keywords: laparotomies; mortality; obese; obesity; patients; trauma cache: cord-011221-rhyxp4v5.txt plain text: cord-011221-rhyxp4v5.txt item: #236 of 2876 id: cord-011255-9q2frk71 author: Kippnich, Maximilian title: Dual-room twin-CT scanner in multiple trauma care: first results after implementation in a level one trauma centre date: 2020-04-25 words: 3451 flesch: 52 summary: Whole-body CT during the initial diagnostic work-up of patients with multiple trauma is mainly accepted as standard in trauma resuscitation care The major reason for fatal outcome in trauma patients is the delay in life-saving surgery [1] . keywords: emergency; patients; resuscitation; room; surgery; trauma cache: cord-011255-9q2frk71.txt plain text: cord-011255-9q2frk71.txt item: #237 of 2876 id: cord-011284-u4qmvz3c author: Livingston, Nicholas A. title: Addressing Diversity in PTSD Treatment: Clinical Considerations and Guidance for the Treatment of PTSD in LGBTQ Populations date: 2020-03-16 words: 5253 flesch: 21 summary: We also offered suggestion for screening, assessment, and evidenced-based trauma and minority stress treatment to guide clinicians in the absence of established guidelines. A psychological mediation framework Daily minority stress and affect among gay and bisexual men: a 30-day diary study Predicting PTSD severity from experiences of trauma and heterosexism in lesbian and bisexual women: a longitudinal study of cognitive mediators Longitudinal study of the effects of trauma and minority stressors (e.g., discrimination) on proximal stressors (e.g., shame, internalized heterosexism) and PTSD symptoms among sexual minority individuals Expecting rejection: understanding the minority stress experiences of transgender and gender-nonconforming individuals Experiences of trauma, discrimination, microaggressions, and minority stress among traumaexposed LGBT veterans: unexpected findings and unresolved service gaps Qualitative account of LGBTQ veterans' intersecting and overlapping experiences of trauma, discrimination, microaggressions, and related PTSD and other mental health symptom sequelae. keywords: discrimination; health; identity; individuals; minority; patients; ptsd; stress; trauma; treatment cache: cord-011284-u4qmvz3c.txt plain text: cord-011284-u4qmvz3c.txt item: #238 of 2876 id: cord-011296-nutl2ovk author: Wu, Venus Kit Sze title: Prevalence, Clinical Characteristics, and Outcomes Related to Ventilator-Associated Events in Neurocritically Ill Patients date: 2020-01-23 words: 3576 flesch: 34 summary: This is contradictory to prior studies on non-neurologically critically ill patients, which demonstrated that VAE patients are twice as likely to die than non-VAE patients [24] . Patients with isolated spinal cord injury may be exquisitely susceptible to VAE events. keywords: care; days; events; injury; patients; study; vae; ventilator cache: cord-011296-nutl2ovk.txt plain text: cord-011296-nutl2ovk.txt item: #239 of 2876 id: cord-011297-4um9w2dx author: Brunker, Lucille title: New-Onset Refractory Status Epilepticus with Underlying Autoimmune Etiology: a Case Report date: 2019-11-28 words: 2963 flesch: 34 summary: For neurologic protection, the patient was initiated on burst suppression therapy, with a target of 1-2 epileptic bursts per screen on EEG monitor. Despite treatment with multiple anti-epileptic drugs in addition to IV anesthetics, burst suppression was initially unsustainable and the patient remained in super-refractory status epilepticus. keywords: autoimmune; eeg; epilepticus; patient; status; suppression; therapy cache: cord-011297-4um9w2dx.txt plain text: cord-011297-4um9w2dx.txt item: #240 of 2876 id: cord-011302-pfepyvaw author: Edlmann, Ellie title: The changing face of neurosurgery for the older person date: 2020-04-25 words: 3897 flesch: 37 summary: The barrow ruptured aneurysm Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial Dexamethasone therapy versus surgery for chronic subdural haematoma (DECSA trial): study protocol for a randomised controlled trial International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial National Institute for Health and Clinical Excellence (NICE) (2014) Head injury: assessment and early management clinical guidelines [CG176 Subarachnoid haemorrhage in patients %3e or = 75 years: clinical course, treatment and outcome The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review A global clinical measure of fitness and frailty in elderly people International subarachnoid aneurysm trial of neurosurgical clipping versus endovascular coiling Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial Minimally invasive surgery for intracerebral hemorrhage Aneurysmal subarachnoid hemorrhage in elderly patients: long-term outcome and prognostic factors in an interdisciplinary treatment approach Importance of frailty evaluation in the prediction of the prognosis of patients with chronic subdural hematoma Oertel Matthias F (2012) Intracerebral hemorrhage in the Very Old Endovascular treatment of intracranial aneurysms in elderly patients Efficacy and safety of minimal invasive surgery treatment in hypertensive intracerebral hemorrhage: a systematic review and meta-analysis The MRC CRASH trial collaborators (2020) However, poor outcomes still prevail in older patients with emergency presentations: Whitehouse reported 5-year mortality of around 55% in neurosurgical patients over 65 admitted as an emergency compared with less than 20% in elective patients [42] . keywords: age; frailty; outcome; patients; treatment; trial; years cache: cord-011302-pfepyvaw.txt plain text: cord-011302-pfepyvaw.txt item: #241 of 2876 id: cord-011327-zsoc4wec author: Martin-Loeches, Ignacio title: Antibiotic prophylaxis in the ICU: to be or not to be administered for patients undergoing procedures? date: 2019-11-28 words: 1974 flesch: 19 summary: Antimicrobial prophylaxis may be administered to patients undergoing a surgical procedure during their ICU stay and as a non-surgical prophylaxis to ICU patients who undergo insertion of an external-internal foreign body that remains in situ for a prolonged period of time. There are no randomised controlled trials on the effects of timing or choice of antibiotic prophylaxis on the outcomes of ICU patients requiring unplanned surgical procedures. keywords: antibiotic; icu; patients; pneumonia; prophylaxis cache: cord-011327-zsoc4wec.txt plain text: cord-011327-zsoc4wec.txt item: #242 of 2876 id: cord-011349-bykvn367 author: Rajasekaran, Raja Bhaskara title: Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases date: 2019-08-07 words: 3515 flesch: 50 summary: By permitting immediate full weight-bearing ambulation and with most patients returning to an acceptable functional status, cemented megaprosthesis is a viable and useful single-stage management option in elderly patients with DFN. key: cord-011349-bykvn367 authors: Rajasekaran, Raja Bhaskara; Palanisami, Dhanasekara Raja; Natesan, Rajkumar; Jayaramaraju, Dheenadhayalan; Rajasekaran, Shanmuganathan title: Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases date: 2019-08-07 journal: Int Orthop DOI: 10.1007/s00264-019-04383-1 sha: doc_id: 11349 cord_uid: bykvn367 PURPOSE OF THE STUDY: To evaluate the outcomes and complications using cemented megaprosthesis in elderly patients with distal femur nonunions (DFN). keywords: cases; dfn; femur; fractures; knee; patients; study; surgery cache: cord-011349-bykvn367.txt plain text: cord-011349-bykvn367.txt item: #243 of 2876 id: cord-011360-1n998win author: Zloto, Keren title: Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery date: 2019-11-15 words: 3411 flesch: 37 summary: Patients with higher postoperative lactate values had lower preoperative miRNA-208a levels. We tested whether preoperative levels of miRNAs-208a can serve as such a biomarker. keywords: complications; heart; levels; mirna-208a; patients; preoperative; surgery cache: cord-011360-1n998win.txt plain text: cord-011360-1n998win.txt item: #244 of 2876 id: cord-011413-yv4x8viu author: Shekar, Kiran title: Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date: 2020-05-12 words: 7481 flesch: 35 summary: Adhere to local or institutional policies on PPE use for COVID-19 patients ECMO initiation, and decannulation and bedside care should be performed with appropriate airborne plus contact precaution PPE including N95/FFP2 mask, gown, cap, eye protection (e.g., goggles or visor) ECMO initiation, decannulation, and all AGPs be performed with PPE and N95 masks or PAPR with full contact precautions Although caring for COVID-19 ECMO patients wear appropriate PPE including N95/FFP2 masks, gowns, cap, eye protectors (e.g., goggles, visor) and follow contact precautions For procedures in which splashing or aerosol generation is anticipated, a higher level of protection (e.g., gown at AAMI level 3 or equivalent) should be considered 18 Labor-intensive procedures (e.g., mobilization, prone positioning, transport) carry significant risk of infection control breach to staff. • ECMO programs should keep a manifest of all team members who are trained to care for ECMO patients. keywords: cannulation; capacity; care; centers; covid-19; ecmo; elso; extracorporeal; guidelines; hospital; membrane; oxygenation; pandemic; patients; ppe; risk; support; use cache: cord-011413-yv4x8viu.txt plain text: cord-011413-yv4x8viu.txt item: #245 of 2876 id: cord-011483-zc6ve6le author: Leclerc, Angela M. title: Amantadine and Modafinil as Neurostimulants Following Acute Stroke: A Retrospective Study of Intensive Care Unit Patients date: 2020-05-20 words: 5734 flesch: 40 summary: This study represents the largest cohort of stroke patients treated with neurostimulants during their acute hospitalization, and suggests amantadine started in the first week after stroke may be associated with improved wakefulness or responsiveness in approximately half of treated patients. Due to the paucity of published data for stroke patients treated with neurostimulants in the acute setting, no protocols or robust data were available to guide us or allow for a power calculation. keywords: acute; administration; amantadine; modafinil; n =; neurostimulant; patients; rehabilitation; stroke; study cache: cord-011483-zc6ve6le.txt plain text: cord-011483-zc6ve6le.txt item: #246 of 2876 id: cord-011512-gw2sk90q author: Houlston, E. title: A simple pleasure date: 2020-05-22 words: 1935 flesch: 48 summary: It is worthwhile readers being aware of these kinds of tools that are available to patients so that the appropriate advice can be given. S. Pahal, Bristol, UK https://doi.org/10.1038/s41415-020-1685-5 Sir, I enjoyed the paper entitled Experience of listening to music on patient anxiety during minor oral surgery procedures: a pilot study by Gupta and Ahmed 1 and feel that music can be an invaluable tool in calming patients during procedures. Both organisations provide patients with expert and evidence-based information that relates to their oral, orthodontic and overall health. keywords: face; factors; music; patients; treatment cache: cord-011512-gw2sk90q.txt plain text: cord-011512-gw2sk90q.txt item: #247 of 2876 id: cord-011533-im78xwl8 author: Gloude, Nicholas J. title: Thinking Beyond HLH: Clinical Features of Patients with Concurrent Presentation of Hemophagocytic Lymphohistiocytosis and Thrombotic Microangiopathy date: 2020-05-23 words: 4881 flesch: 31 summary: In our prior prospective study examining complement genes in HSCT, we observed a significant association between TMA severity and outcomes in HLH patients undergoing HSCT who had complement gene variants identified. Transplant-related mortality was also significantly higher in HLH patients with TMA with six patients of the 9 patients dying from TMA-associated complications, while all HLH patients without TMA survived after transplant (6/9 67% vs 0/8, 0%, p = 0.09) keywords: activation; complement; eculizumab; hlh; hypertension; injury; interferon; organ; patients; therapy; tma cache: cord-011533-im78xwl8.txt plain text: cord-011533-im78xwl8.txt item: #248 of 2876 id: cord-011649-3dlsy8fl author: Limoncelli, Janine title: General Anesthesia Recommendations for Electroconvulsive Therapy During the Coronavirus Disease 2019 Pandemic date: 2020-06-12 words: 1640 flesch: 37 summary: Given the penetrance of COVID-19 in the New York metropolitan area, the Weill Cornell Medicine NewYork-Presbyterian Hospital Anesthesiology and Psychiatry departments collaborated to develop guidelines to ensure that the patients who were in urgent need of ECTwere provided that care while minimizing exposure to the staff and potential spread of disease to other ECT patients. Although the majority of patients recover, there are still a significant number of patients who progress to respiratory failure, multiorgan failure, and death. keywords: anesthesia; ect; mask; patient; ventilation cache: cord-011649-3dlsy8fl.txt plain text: cord-011649-3dlsy8fl.txt item: #249 of 2876 id: cord-011712-fyrbe8tw author: Venkatesan, Sudhir title: Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection date: 2020-02-01 words: 4625 flesch: 33 summary: Additionally, where data were available, we defined 3 further exposure variables: NAI treatment (at any time) versus no NAI treatment, early NAI treatment (initiated within ≤2 days after symptom onset) versus no NAI treatment, and early NAI treatment versus later treatment (initiated >2 days after symptom onset). In addition, we performed secondary analyses for the following exposures: NAI treatment (at any time) versus no NAI treatment, early NAI treatment (≤48 hours after symptom onset) versus later NAI treatment (>48 hours after symptom onset), and early NAI treatment versus no NAI treatment, adjusting for propensity score, in-hospital antibiotic treatment, and corticosteroid treatment. keywords: data; days; hospital; influenza; los; nai; nai treatment; onset; patients; treatment cache: cord-011712-fyrbe8tw.txt plain text: cord-011712-fyrbe8tw.txt item: #250 of 2876 id: cord-011725-t1jl4cy1 author: Varma, Niraj title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 words: 3651 flesch: 30 summary: In COVID-19 patients receiving prior antiarrhythmic therapy, there should be a thorough consideration of risk vs benefit before initiating any QT-prolonging COVID-19 therapies, especially considering their unproven value. Clinical characteristics of Covid-19 in New York City Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) Transient complete heart block in a patient with critical COVID-19 A young woman presenting with a viral prodrome, palpitations, dizziness, and heart block Cardiac and arrhythmic complications in patients with COVID-19 Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: a statement from the Canadian Heart Rhythm Society How to protect the protectors: 10 lessons to learn for doctors fighting the COVID-19 coronavirus Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry Comparison of QT interval readings in normal sinus rhythm between a smartphone heart monitor and a 12-lead ECG for healthy volunteers and inpatients receiving sotalol or dofetilide A wearable remote monitoring system for the identification of subjects with a prolonged QT interval or at risk for drug-induced long QT syndrome Can smartphone wireless ECGs be used to accurately assess ECG intervals in pediatrics? keywords: azithromycin; care; covid-19; ecg; health; hydroxychloroquine; monitoring; patients; qtc; risk cache: cord-011725-t1jl4cy1.txt plain text: cord-011725-t1jl4cy1.txt item: #251 of 2876 id: cord-011793-hlktpla4 author: Rice, Todd W. title: In Defense of Evidence-based Medicine for the Treatment of COVID-19 Acute Respiratory Distress Syndrome date: 2020-07-17 words: 1829 flesch: 32 summary: n Effective treatment of severe COVID-19 patients with tocilizumab Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): a case series Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-a fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study Effect of intravenous interferon b-1a on death and days free from mechanical ventilation among patients with moderate to severe acute respiratory distress syndrome: a randomized clinical trial Randomized clinical trial of activated protein C for the treatment of acute lung injury National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. In Defense of Evidence-based Medicine for the Treatment of COVID-19 Acute Respiratory Distress Syndrome date: 2020-07-17 journal: Ann Am Thorac Soc DOI: 10.1513/annalsats.202004-325ip sha: doc_id: 11793 cord_uid: hlktpla4 nan Severe acute respiratory failure from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus disease has challenged intensivists worldwide with both increased severity of illness and quantity of patients. keywords: acute; care; covid-19; patients; trials cache: cord-011793-hlktpla4.txt plain text: cord-011793-hlktpla4.txt item: #252 of 2876 id: cord-011836-zib8wkm2 author: Urman, Jesús M. title: Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach date: 2020-06-21 words: 13609 flesch: 40 summary: Their identity, variations in control vs. PDAC bile samples and contribution to intergroup variability are presented in Figure S3d . Their identity, variations in control vs. PDAC bile samples and contribution to intergroup variability are presented in Figure S3d . keywords: analysis; bas; benign; bile; bile samples; biliary; cca; cca patients; dapc; data; features; figure; human; learning; levels; machine; malignant; nmr; patients; pdac patients; proteins; samples; serum; species cache: cord-011836-zib8wkm2.txt plain text: cord-011836-zib8wkm2.txt item: #253 of 2876 id: cord-011875-ga0dzj3v author: Tsolaki, Vasiliki title: Are Patients with COVID-19 Dying of or with Cardiac Injury? date: 2020-07-15 words: 1312 flesch: 38 summary: Basing respiratory management of COVID-19 on physiological principles Principles and practice of mechanical ventilation Philosophy of medicine: an introduction Use of high-flow nasal cannula oxygen therapy in subjects with ARDS: a 1-year observational study A multiple-center survey on the use in clinical practice of noninvasive ventilation as a first-line intervention for acute respiratory distress syndrome Consilience: the unity of knowledge Clinical features of 85 fatal cases of COVID-19 from Wuhan: a retrospective observational study Pathophysiology of Takotsubo syndrome Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirusinfected pneumonia in Wuhan, China New insights into the mechanisms involved in B-type natriuretic peptide elevation and its prognostic value in septic patients Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) Very few reports have used echocardiographic criteria beyond biomarkers to diagnose cardiac injury, but none have differentiated between myocarditis, cardiomyopathy (stress or septic), ACS, and acute heart failure in the era of COVID-19. keywords: ards; covid-19; injury; patients cache: cord-011875-ga0dzj3v.txt plain text: cord-011875-ga0dzj3v.txt item: #254 of 2876 id: cord-011975-8vl45xb7 author: Keser, Tobias title: Risk Factors for Dysphagia and the Impact on Outcome After Spontaneous Subarachnoid Hemorrhage date: 2019-11-15 words: 3806 flesch: 37 summary: These novel approaches may be of special interest in SAH patients, as prolonged mechanical ventilation is common in poor admission grade patients rendering an early time window for these interventions. Although the incidence of swallowing disorders has been extensively studied in ischemic stroke patients, little is known about the true incidence of dysphagia in SAH patients and its contribution to the clinical course and outcome. keywords: bods; dysphagia; outcome; patients; sah; study; swallowing cache: cord-011975-8vl45xb7.txt plain text: cord-011975-8vl45xb7.txt item: #255 of 2876 id: cord-012025-faj682bp author: Savioli, Felicio title: Coagulation profile in severe COVID-19 patients: what do we know so far? date: 2020 words: 812 flesch: 26 summary: Conflicts of interest: None ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Hypercoagulability of COVID-19 patients in Intensive Care Unit. key: cord-012025-faj682bp authors: Savioli, Felicio; Rocha, Leonardo Lima title: Coagulation profile in severe COVID-19 patients: what do we know so far? date: 2020 journal: Rev Bras Ter Intensiva DOI: 10.5935/0103-507x.20200031 sha: doc_id: 12025 cord_uid: faj682bp nan Furthermore, Panigada et al. keywords: coagulation; covid-19; patients cache: cord-012025-faj682bp.txt plain text: cord-012025-faj682bp.txt item: #256 of 2876 id: cord-012037-9kmul7he author: Veenis, J. F. title: Remote monitoring of chronic heart failure patients: invasive versus non-invasive tools for optimising patient management date: 2019-11-19 words: 4458 flesch: 32 summary: A randomized controlled trial Effectiveness of remote patient monitoring after discharge of hospitalized patients with heart failure: the Better Effectiveness After Transition-Heart Failure (BEAT-HF) randomized clinical trial Theeffectof arandomizedtrial of home telemonitoring on medical costs, 30-day readmissions, mortality, and health-related quality of life in a cohort of community-dwelling heart failure patients Effects of remote monitoring on clinical outcomes and use of healthcare resources in heart failure patients with biventricular defibrillators: results of the MORE-CARE multicentre randomized controlled trial Fluid status monitoring with a wireless network to reduce cardiovascularrelatedhospitalizations andmortality in heartfailure: rationale and design of the OptiLink HF Study (Optimization of Heart Failure Management using OptiVol Fluid Status Monitoring and CareLink) Remote management of heart failure using implantable electronic devices Intrathoracic impedance monitoring, audible patient alerts, and outcome in patients with heart failure Remote monitoring improves outcome after ICD implantation: the clinical efficacy in the management of heart failure (EFFECT) study Impact of remote monitoring on long-term prognosis in heart failure patients in a real-world cohort: results from all-comers COMMIT-HF trial Implant-based multiparameter telemonitoring of patients with heart failure (IN-TIME): a randomised controlled trial Fluid status telemedicine alerts for heart failure: a randomized controlled trial The impact of remote monitoring of implanted cardioverter-defibrillator (ICD) and cardiac resynchronisation therapy device (CRT-D) patients on healthcare costs in the Silesian population: threeyear follow-up Effect of telemonitoring of cardiac implantable electronic devices on healthcare utilization: a meta-analysis of randomized controlled trials in patients with heart failure A multisensor algorithm predicts heart failure events in patients with implanted devices: results from the MultiSENSE study HeartLogic multisensor algorithm identifies patients during periods of significantly increased risk of heart failure events: results from the MultiSENSE study Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure: the COMPASS-HFstudy Hemodynamic monitoring in advanced heart failure: results from the LAPTOP-HF trial CHAMPION trial rationale and design: the long-term safety and clinical efficacy of a wireless pulmonary artery pressuremonitoring system Validating left ventricular filling pressure measurements in patients with congestive heart failure: CardioMEMS pulmonary arterial diastolic pressure versus left atrial pressure measurement by transthoracic echocardiography Comparison of a radiofrequency-based wireless pressure sensor to swanganz catheter and echocardiography for ambulatory assessmentof pulmonary artery pressurein heartfailure Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete followup results from the CHAMPION randomised trial Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial Postmarketing adverse events related to the CardioMEMSHFsystem Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers Interventions linked to decreased heart failure hospitalizations during ambulatory pulmonary artery pressure monitoring Pulmonary artery pressure-guided heart failure management reduces 30-day readmissions Impact of practicebased management of pulmonary artery pressures in 2000 patients implanted with the CardioMEMS sensor. keywords: cardiomems; care; device; failure; heart; monitoring; patients; trial cache: cord-012037-9kmul7he.txt plain text: cord-012037-9kmul7he.txt item: #257 of 2876 id: cord-012115-hpsxi9ay author: Archie, Patrick title: Music-based interventions in palliative cancer care: a review of quantitative studies and neurobiological literature date: 2013-05-30 words: 6736 flesch: 33 summary: A study in hospitalized advanced cancer patients Anxiety disorders in advanced cancer patients Depression and anxiety disorders in palliative cancer care Role of interactive music in oncological pediatric patients undergoing painful procedures Effectiveness of music therapy for anxiety reduction in women with breast cancer in chemotherapy treatment Reducing treatment-related anxiety in cancer patients: comparison of psychological interventions Music as a therapeutic intervention for anxiety in patients receiving radiation therapy The effect of music on preoperative anxiety in day surgery A comparison of intraoperative or postoperative exposure to music-a controlled trial of the effects on postoperative pain Stress reduction and analgesia in patients exposed to calming music postoperatively: a randomized controlled trial Sedative music reduces anxiety and pain during chair rest after open-heart surgery Duocastella AC (1999) Effect of music on children with cancer The quality of life of cancer patients: a review of the literature General Population and cancer patient norms for the Functional Assessment of Cancer Therapy-General (FACT-G) Health-related quality of life in longterm head and neck cancer survivors: a comparison with general population norms ed) Handbook of pain and palliative care: biobehavioral approaches for the life course Defining the content domain of quality of life for cancer patients with pain keywords: anxiety; cancer; cancer patients; care; depression; interventions; life; mood; music; pain; palliative; patients; studies; therapy cache: cord-012115-hpsxi9ay.txt plain text: cord-012115-hpsxi9ay.txt item: #258 of 2876 id: cord-012117-c693oefo author: Diaz-Padilla, Ivan title: A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors date: 2013-10-01 words: 4708 flesch: 45 summary: Temsirolimus was administered weekly and RO4929097 was given on a 3-days on/4-days off schedule, prior to temsirolimus administration Patients were withdrawn from the study if they failed to recover to grade ≤1 or tolerable grade 2 (or within 1 grade of starting values for pre-existing laboratory abnormalities) from a treatment-related toxicity within 14 days or if they experienced an agent-related AE that required dose modification despite the number of permitted dose reductions (Supplementary Table 1 ). Patients could continue on study treatment until progressive disease was documented. keywords: cell; cycle; days; dose; grade; notch; pathway; patients; ro4929097; study; temsirolimus; treatment cache: cord-012117-c693oefo.txt plain text: cord-012117-c693oefo.txt item: #259 of 2876 id: cord-012459-tge08va0 author: Matthews, Laura J. title: Airway Alert Bracelets: Enhancing Safety in the Coronavirus Disease 2019 Era date: 2020-08-18 words: 627 flesch: 41 summary: We are concerned that potential key information about patients with difficult airways can be missed. The presence of this bracelet on a patient prompts a review of the electronic intubation notes before undertaking any procedure where the airway could be at risk, and appropriate measures to be put in place-for example, a senior anesthetist with the relevant equipment present when airway alert patients are proned or deproned. keywords: airway; patients cache: cord-012459-tge08va0.txt plain text: cord-012459-tge08va0.txt item: #260 of 2876 id: cord-012469-6cvu5umd author: Lewis, Jayne title: Speaking with Frankenstein date: 2020-08-21 words: 8505 flesch: 49 summary: As a professor of literature and a professor of medicine, we are especially interested in what it might mean to speak with Victor Frankenstein and his Creature because this process can provide creative insight into the relationships that develop between modern-day physicians and the patients incorporates distance and disappointment as well as recognition and rehabilitation, unresolved fear as well as pragmatic hope. We find that Shelley anticipated such possibilities when she staged a series of broken yet still promising interactions between her protagonists, the failed medical student Victor Frankenstein and the Creature into whose crowd-sourced, incoherent body-once a lifeless thing-Victor infuse[s] a spark of being (Shelley 1993, 38 ). keywords: creature; death; difference; disgust; frankenstein; life; medicine; narrative; patient; physician; shelley; speaking; victor; walton cache: cord-012469-6cvu5umd.txt plain text: cord-012469-6cvu5umd.txt item: #261 of 2876 id: cord-012518-ncrdwtdg author: None title: Abstractband DOG 2020 date: 2020-08-24 words: 32667 flesch: 52 summary: In 1852 he founded famous private eye clinic in Berlin, where he treated many eye patients and educated many prominent ophthalmologists. In I group patients were examined before the first time and after 3 months of SCL wear. keywords: a. 1; acuity; age; analysis; anti; auf; baseline; bei; cases; cells; changes; cnv; conclusions; control; corneal; data; der; des; diabetic; die; disease; eine; expression; eyes; following; für; germany; glaucoma; group; gruppe; implant; incidence; iod; iop; length; lens; light; mean; membrane; methods; mit; mmhg; months; n =; nach; non; oct; optic; oxygen; patienten; patients; primary; purpose; results; sich; stage; studies; study; surgery; survival; term; therapy; thickness; time; treatment; und; uveitis; von; war; werden; years cache: cord-012518-ncrdwtdg.txt plain text: cord-012518-ncrdwtdg.txt item: #262 of 2876 id: cord-012560-p5s0p7fd author: Decavèle, Maxens title: One-year survival of patients with high-grade glioma discharged alive from the intensive care unit date: 2020-08-29 words: 3720 flesch: 39 summary: Because the prognosis of cancer patients is similar to that of non-cancer patients [1, 3] , a diagnosis of cancer should not preclude ICU admission. Incidence, life expectancy and prognostic factors in cancer patients under prolonged mechanical ventilation: a nationwide analysis of 5138 cases during The impact of critical illness on perceived health-related quality of life during ICU treatment, ICU stay, and after ICU discharge Long-term survival, quality of life, and quality-adjusted survival in critically ill patients with cancer Quality of life after intensive care: a systemic review of the literature Long-term health-related quality of life of critically ill patients with haematological malignancies: a prospective observational multicenter study Review on quality of life issues in patients with primary brain tumors Health-related quality of life in patients with high grade gliomas: a quantitative longitudinal study Glioblastoma and other malignant gliomas: a clinical review The 2016 world health organization classification of tumors of the central nervous system: a summary A new method of classifying prognostic comorbidity in longitudinal studies: development and validation New simplified acute physiology score (SAPS II] based on a European/North American multicenter study The SOFA (Sepsis-related Organ Failure Assessment] score to describe organ dysfunction/failure. keywords: admission; anticancer; icu; patients; performance; status; therapy; year cache: cord-012560-p5s0p7fd.txt plain text: cord-012560-p5s0p7fd.txt item: #263 of 2876 id: cord-012665-fflye8a3 author: Marques-Vidal, Pedro title: Statistical issues regarding the article by Liu et al. date: 2020-09-02 words: 242 flesch: 71 summary: Clinical significance of nutritional risk screening for older adult patients with COVID-19 It seems that the authors computed the OR for the non-at risk patients. keywords: patients cache: cord-012665-fflye8a3.txt plain text: cord-012665-fflye8a3.txt item: #264 of 2876 id: cord-012778-yr8zuvw9 author: Zhang, Lei title: Quantitative efficacy of three antipsychotic drugs for schizophrenia based on a real-world study in China date: 2019-08-06 words: 5060 flesch: 41 summary: All of these evaluation results indicated good predictability of the final models. Typical drug efficacy values According to the final model parameters, we examined the efficacy values of the three antipsychotics at 26, 52, 78, 104, 130, and 156 weeks and simulated the typical efficacy-time curves (Fig. 3a) . The CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness) schizophrenia study conducted by the National Institute of Mental Health (NIMH) is the most wellknown comparative study of the effectiveness of antipsychotic drugs [10, 11] . keywords: antipsychotic; efficacy; model; olanzapine; patients; risperidone; schizophrenia; score; study cache: cord-012778-yr8zuvw9.txt plain text: cord-012778-yr8zuvw9.txt item: #265 of 2876 id: cord-012902-efprpk72 author: None title: Abstracts from the 2020 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS) date: 2020-09-15 words: 10233 flesch: 50 summary: This study investigates the feasibility of CPET for safe and effective cardiovascular exercise prescription in hypertensive patients Methods: 14 subjects (10 Male, 4 Female; aged 61.8 ± 10.8 years) with hypertension and undergoing medical therapy were recruited to the study. Introduction: High sodium (Na) and inadequate potassium (K) intake are important determinants of high blood pressure (BP) and cardiovascular diseases (CVDs). keywords: age; blood; conclusions; disclosures; hypertension; mean; methods; mmhg; patients; pressure; results; risk; salt; study; years cache: cord-012902-efprpk72.txt plain text: cord-012902-efprpk72.txt item: #266 of 2876 id: cord-012934-c6pbr64i author: Hao, Weiming title: Vestibular prognosis in idiopathic sudden sensorineural hearing loss with vestibular dysfunction treated with oral or intratympanic glucocorticoids: a protocol for randomized controlled trial date: 2020-07-22 words: 5456 flesch: 38 summary: To evaluate the recovery of vestibular function, we set the recovery rates of the whole battery of vestibular function tests (SOT/caloric test/vHIT/VEMPs) as the primary outcome, which is the proportion of patients whose abnormal results of vestibular function tests at baseline recover to normal at 4-/8-week follow-up: in this study, we define a 10-dB PTA criterion as clinically significant difference based on a previous RCT [9] . For comparisons of recovery in 4 and 8 weeks from baseline, the recovery rates of vestibular function tests will be calculated by chi-squared tests, and logistic regression adjusts for potential confounders like age, initial PTA, the number of involved vestibular organs, MRI-IAC results, and other characteristics, while the numerical variables like UW of the caloric test, PTA, and scores in DHI, VAS-V, and VAS-T will be calculated by mixed-model with repeated measures analyses of variance (ANOVA), with group and time as fixed effects and subject as a random effect, controlling for the potential confounders. keywords: caloric; dysfunction; function; hearing; issnhl; loss; patients; recovery; study; test; trial; vestibular cache: cord-012934-c6pbr64i.txt plain text: cord-012934-c6pbr64i.txt item: #267 of 2876 id: cord-013003-gxd29jxf author: Vora, Darshan title: Surgical management of a complex case of Charcot arthropathy of the spine: a case report date: 2019-08-22 words: 2272 flesch: 39 summary: Further research is necessary to decrease morbidity in CAS patients and establish a consensus for surgical management. Per patients request, the retained bullet in the paraspinal musculature was removed. keywords: arthropathy; case; charcot; management; patient; spinal; spine cache: cord-013003-gxd29jxf.txt plain text: cord-013003-gxd29jxf.txt item: #268 of 2876 id: cord-013035-7sfj0czv author: Savinelli, Stefano title: Reply date: 2020-09-20 words: 1259 flesch: 31 summary: On the other hand, the risk of bacterial infection may be higher in the ICU setting, where more frequent use of vascular and other indwelling devices represent a risk for bloodstream infections (BSI), which are also often reported in patients with COVID-19. In this context, perhaps early rather than late administration in COVID-19 ward patients could be of certain value, before the need of intensive care and at the very beginning of inflammatory cascade, based on specific diagnostic criteria that need to be clearly established. keywords: covid-19; patients; tocilizumab cache: cord-013035-7sfj0czv.txt plain text: cord-013035-7sfj0czv.txt item: #269 of 2876 id: cord-013105-tmhce7p5 author: Kalil, Andre C. title: Less is more: critically ill status is not a carte blanche for unlimited antibiotic use date: 2020-10-09 words: 1497 flesch: 23 summary: VAT is an ill-defined syndrome with lowquality scientific evidence, poorly predictive of progression to VAP and not associated with higher mortality than ICU patients without VAT; this led the IDSA/ATS guideline to recommend against the use of antibiotics in patients with suspected VAT Given that more than half of ICU patients receive antimicrobial therapy keywords: antibiotics; patients; pneumonia; resistance cache: cord-013105-tmhce7p5.txt plain text: cord-013105-tmhce7p5.txt item: #270 of 2876 id: cord-013116-n7auvqh3 author: Srinivas, A. title: Testing the limits of UDCs date: 2020-10-09 words: 797 flesch: 52 summary: We hope this may serve as a timely reminder of the limitations of remote consultations and the possible consequences of a lack of continuity of care in any one setting. A. Srinivas, C. Moshkun, J. Darcey, Manchester, UK https://doi.org/10.1038/s41415-020-2226-y missing a serious diagnosis or misdiagnosing. Furthermore, remote consultation requires a different communication approach and arguably more thorough history taking to triage those that require a face-to-face appointment. keywords: dental; face; patient cache: cord-013116-n7auvqh3.txt plain text: cord-013116-n7auvqh3.txt item: #271 of 2876 id: cord-013139-b32xg7y7 author: Colak, Fatma Kurt title: An intronic variant in BRAT1 creates a cryptic splice site, causing epileptic encephalopathy without prominent rigidity date: 2020-10-10 words: 2798 flesch: 40 summary: Since the discovery of BRAT1 variants as the molecular etiology of lethal neonatal rigidity and multifocal seizure syndrome (RMFSL, OMIM 614498), these variants have also been identified in patients with milder clinical forms including neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS, OMIM 618056), epilepsy of infancy with migrating focal seizures (EIMFS), and congenital ataxia (CA). RMFSL was first described in 2012; later, BRAT1 variants were also reported in patients with non-lethal milder clinical forms, including neurodevelopmental disorder with cerebellar atrophy and with or without seizures (NEDCAS, 618056), epilepsy of infancy with migrating focal seizures (EIMFS), and congenital ataxia (CA) keywords: brat1; day; patient; rigidity; seizures; site; splice; variant cache: cord-013139-b32xg7y7.txt plain text: cord-013139-b32xg7y7.txt item: #272 of 2876 id: cord-013148-qbxbndsl author: Manzano-Nunez, Ramiro title: Outcomes and management approaches of resuscitative endovascular balloon occlusion of the aorta based on the income of countries date: 2020-10-12 words: 3933 flesch: 39 summary: These factors may have a significant impact on the care, and surgical outcome of REBOA resuscitated patients. We urge a shift in REBOA surgical practice toward ultrasound-guided access, with surgeons adopting a more cautious, safe, and systematic approach to REBOA insertion and deployment. keywords: aorta; countries; income; lmics; occlusion; patients; reboa; trauma cache: cord-013148-qbxbndsl.txt plain text: cord-013148-qbxbndsl.txt item: #273 of 2876 id: cord-013149-y0dbhtef author: Wohlfarth, P. title: Hämatoonkologie und Intensivmedizin: Vom Tabu zur Conditio sine qua non date: 2020-10-12 words: 2340 flesch: 24 summary: Etliche Studien zeigen eine deutlich verbesserte Mortalität von primär intubierten immunsupprimierten Patienten mit ARV. Zusammenfassend bestehen bei deutlich gesunkenen Mortalitätsraten invasiv beatmeter Krebspatienten mit ARV in den vergangenen Jahren keine eindeutigen Hinweise mehr für die Vorteile einer NIV oder HFNO im Vergleich zu einer konventionellen O2-Insufflation. keywords: arv; auf; bei; cancer; care; den; der; die; eine; failure; für; krebspatienten; management; mit; niv; patienten; patients; und; werden cache: cord-013149-y0dbhtef.txt plain text: cord-013149-y0dbhtef.txt item: #274 of 2876 id: cord-013370-gktnz644 author: Abreu, Maria T title: Providing Guidance During a Global Viral Pandemic for the Care of Patients With Inflammatory Bowel Disease date: 2020-10-21 words: 1841 flesch: 51 summary: We have tried to remain cognisant of the fact that the majority of IBD patients are being cared for by general gastroenterologists who are all doing their best during this epidemic to keep their patients, staff, and themselves safe from infection. We have recently published a study looking at the expression of the two receptors that are required for viral entry and found that, in IBD patients and in healthy people, these receptors called ACE2 and TMPRSS2 are both expressed in the gut. keywords: covid-19; disease; guidance; ibd; patients cache: cord-013370-gktnz644.txt plain text: cord-013370-gktnz644.txt item: #275 of 2876 id: cord-013380-1jwzbgwb author: Parrilla, Claudio title: A one-year time frame for voice prosthesis management. What should the physician expect? Is it an overrated job? date: 2020-08-17 words: 3409 flesch: 40 summary: Voice prosthesis patients are, in fact, notoriously characterised by much more frequent visits to healthcare professionals than oesophageal speakers. In our centre, there is a dedicated team for management of voice prosthesis patients consisting of 2 ENT surgeons and 3 speech therapists. keywords: accesses; complications; leakage; management; patients; prosthesis; puncture; rehabilitation; speech; voice cache: cord-013380-1jwzbgwb.txt plain text: cord-013380-1jwzbgwb.txt item: #276 of 2876 id: cord-013457-rqon1adg author: De Cannière, Hélène title: Short-Term Exercise Progression of Cardiovascular Patients throughout Cardiac Rehabilitation: An Observational Study date: 2020-09-29 words: 7370 flesch: 38 summary: Health-related quality of life (HRQoL) assessments were carried out using the Short Form-36 (SF-36) questionnaire and the Minnesota Living with Heart Failure Questionnaire (MLHFQ) at baseline and end-of-study, both validated in CR patients. Although both their mental and physical status improve, CR patients still feel different when compared to healthy subjects after following a CR program. keywords: baseline; capacity; cardiac; exercise; increase; patients; program; progression; rehabilitation; study cache: cord-013457-rqon1adg.txt plain text: cord-013457-rqon1adg.txt item: #277 of 2876 id: cord-013558-0sa63lp3 author: Farwana, Reem title: Watch this space: a systematic review of the use of video-based media as a patient education tool in ophthalmology date: 2020-03-09 words: 2533 flesch: 42 summary: Moorfields Eye Hospital NHS Foundation Trust has been using patient education videos in their waiting rooms, as outlined in the Annual Reports and Accounts 2018/19 (Annual Report 2019) Specialists in the field would best be able to judge patient education videos to maintain accuracy and quality of content. keywords: education; media; patient; review; studies; video cache: cord-013558-0sa63lp3.txt plain text: cord-013558-0sa63lp3.txt item: #278 of 2876 id: cord-013589-3l8kar3k author: Doummar, Diane title: Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia date: 2020-05-28 words: 4149 flesch: 39 summary: Interestingly, analysis of the fibroblasts with the biallelic variants in PDE2A variants revealed mitochondria network morphology changes. After exome analysis, PDE2A variants were confirmed by Sanger sequencing using patient's, and parents' DNA. keywords: camp; disorders; dyskinesia; eeg; epilepsy; fig; interictal; mitochondria; movement; patient; pde2a; variants cache: cord-013589-3l8kar3k.txt plain text: cord-013589-3l8kar3k.txt item: #279 of 2876 id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 words: 99097 flesch: 51 summary: The application of the endotoxin activity assay was useful for bedside monitoring of endotoxemia in ICU patients. The aim of this study is to describe the clinical and epidemiological profi le of ICU patients receiving tigecycline (TGC) and to evaluate the potential benefi ts of TGC higher doses. keywords: acute; admission; adult patients; age; aim; analysis; blood; brain; cardiac; care; care patients; cases; clinical; conclusion; confi; control; criteria; critical; data; days; defi; diff; dose; early; ect; eff; emergency; erence; erent; failure; fi rst; figure; function; group; guidelines; high; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; icus; identifi; increase; infl; injury; intensive; introduction; length; levels; low; lung; management; mean; median; medical; methods; methods patients; minutes; months; mortality; n =; number; nurses; organ; outcome; p =; patients; period; post; pressure; protocol; rate; renal; response; results; risk; rst; score; sepsis; septic; severity; shock; shock patients; signifi; stay; studies; study; surgery; surgery patients; surgical; test; therapy; time; total; treatment; uid; use; ventilation; volume; years cache: cord-014464-m5n250r2.txt plain text: cord-014464-m5n250r2.txt item: #280 of 2876 id: cord-014533-6qfecv5h author: Velasquez, T. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 words: 88447 flesch: 46 summary: key: cord-014533-6qfecv5h authors: Velasquez, T.; Mackey, G.; Lusk, J.; Kyle, U. G.; Fontenot, T.; Marshall, P.; Shekerdemian, L. S.; Coss-Bu, J. A.; Nishigaki, A.; Yatabe, T.; Tamura, T.; Yamashita, K.; Yokoyama, M.; Ruiz-Rodriguez, J. C.; Encina, B.; Belmonte, R.; Troncoso, I.; Tormos, P.; Riveiro, M.; Baena, J.; Sanchez, A.; Bañeras, J.; Cordón, J.; Duran, N.; Ruiz, A.; Caballero, J.; Nuvials, X.; Riera, J.; Serra, J.; Rutten, A. M. F.; van Ieperen, S. N. M.; Der Kinderen, E. P. H. M.; Van Logten, T.; Kovacikova, L.; Skrak, P.; Zahorec, M.; Kyle, U. G.; Akcan-Arikan, A.; Silva, J. C.; Mackey, G.; Lusk, J.; Goldsworthy, M.; Shekerdemian, L. S.; Coss-Bu, J. A.; Wood, D.; Harrison, D.; Parslow, R.; Davis, P.; Pappachan, J.; Goodwin, S.; Ramnarayan, P.; Chernyshuk, S.; Yemets, H.; Zhovnir, V.; Pulitano’, S. M.; De Rosa, S.; Mancino, A.; Villa, G.; Tosi, F.; Franchi, P.; Conti, G.; Patel, B.; Khine, H.; Shah, A.; Sung, D.; Singer, L.; Haghbin, S.; Inaloo, S.; Serati, Z.; Idei, M.; Nomura, T.; Yamamoto, N.; Sakai, Y.; Yoshida, T.; Matsuda, Y.; Yamaguchi, Y.; Takaki, S.; Yamaguchi, O.; Goto, T.; Longani, N.; Medar, S.; Abdel-Aal, I. R.; El Adawy, A. S.; Mohammed, H. M. E. H.; Mohamed, A. N.; Parry, S. M.; Knight, L. D.; Denehy, L.; De Morton, N.; Baldwin, C. E.; Sani, D.; Kayambu, G.; da Silva, V. Z. M.; Phongpagdi, P.; Puthucheary, Z. A.; Granger, C. L.; Rydingsward, J. E.; Horkan, C. M.; Christopher, K. B.; McWilliams, D.; Jones, C.; Reeves, E.; Atkins, G.; Snelson, C.; Aitken, L. M.; Rattray, J.; Kenardy, J.; Hull, A. M.; Ullman, A.; Le Brocque, R.; Mitchell, M.; Davis, C.; Macfarlane, B.; Azevedo, J. C.; Rocha, L. L.; De Freitas, F. F. M.; Cavalheiro, A. M.; Lucinio, N. M.; Lobato, M. S.; Ebeling, G.; Kraegpoeth, A.; Laerkner, E.; De Brito-Ashurst, I.; White, C.; Gregory, S.; Forni, L. G.; Flowers, E.; Curtis, A.; Wood, C. A.; Siu, K.; Venkatesan, K.; Muhammad, J. B. H.; Ng, L.; Seet, E.; Baptista, N.; Escoval, A.; Tomas, E.; Agrawal, R.; Mathew, R.; Varma, A.; Dima, E.; Charitidou, E.; Perivolioti, E.; Pratikaki, M.; Vrettou, C.; Giannopoulos, A.; Zakynthinos, S.; Routsi, C.; Atchade, E.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Genève, C.; Tanaka, S.; Lortat-Jacob, B.; Augustin, P.; Desmard, M.; Montravers, P.; de Molina, F. J. González; Barbadillo, S.; Alejandro, R.; Álvarez-Lerma, F.; Vallés, J.; Catalán, R. M.; Palencia, E.; Jareño, A.; Granada, R. M.; Ignacio, M. L.; Cui, N.; Liu, D.; Wang, H.; Su, L.; Qiu, H.; Li, R.; Jaffal, K.; Rouzé, A.; Poissy, J.; Sendid, B.; Nseir, S.; Paramythiotou, E.; Rizos, M.; Frantzeskaki, F.; Antoniadou, A.; Vourli, S.; Zerva, L.; Armaganidis, A.; Riera, J.; Gottlieb, J.; Greer, M.; Wiesner, O.; Martínez, M.; Acuña, M.; Rello, J.; Welte, T.; Atchade, E.; Mignot, T.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Lortat-Jacob, B.; Tanaka, S.; Augustin, P.; Desmard, M.; Montravers, P.; Soussi, S.; Dudoignon, E.; Ferry, A.; Chaussard, M.; Benyamina, M.; Alanio, A.; Touratier, S.; Chaouat, M.; Lafaurie, M.; Mimoun, M.; Mebazaa, A.; Legrand, M.; Sheils, M. A.; Patel, C.; Mohankumar, L.; Akhtar, N.; Noriega, S. K. Pacheco; Aldana, N. Navarrete; León, J. L. Ávila; Baquero, J. Durand; Bernal, F. Fernández; Ahmadnia, E.; Hadley, J. S.; Millar, M.; Hall, D.; Hewitt, H.; Yasuda, H.; Sanui, M.; Komuro, T.; Kawano, S.; Andoh, K.; Yamamoto, H.; Noda, E.; Hatakeyama, J.; Saitou, N.; Okamoto, H.; Kobayashi, A.; Takei, T.; Matsukubo, S.; Rotzel, H. B.; Lázaro, A. Serrano; Prada, D. Aguillón; Gimillo, M. Rodriguez; Barinas, O. Diaz; Cortes, M. L. Blasco; Franco, J. Ferreres; Roca, J. M. Segura; Carratalá, A.; Gonçalves, B.; Turon, R.; Mendes, A.; Miranda, F.; Mata, P. J.; Cavalcanti, D.; Melo, N.; Lacerda, P.; Kurtz, P.; Righy, C.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Romero, J. C. García; Herrera, A. N. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Hualde, J. Barado; Hernández, A. Ansotegui; Irazabal, J. M. Guergué; Spatenkova, V.; Bradac, O.; Suchomel, P.; Urli, T.; Lazzeri, E. Heusch; Aspide, R.; Zanello, M.; Perez-Borrero, L.; Garcia-Alvarez, J. M.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Rivera-Fernandez, R.; Mora-Ordoñez, J.; De La Fuente-Martos, C.; Castillo-Lorente, E.; Guerrero-Lopez, F.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Pertuz, E. D. Díaz; Hernández, A. Ansotegui; Romero, J. C. García; Sánchez, M. J. Gómez; Herrera, A. N. García; Ramírez, J. Roldán; Sanz, E. Regidor; Hualde, J. Barado; León, J. P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. L.; Pérez, H.; Calpe, P.; Alcala, M. A.; Robaglia, D.; Perez, C.; Lan, S. K.; Cunha, M. M.; Moreira, T.; Santos, F.; Lafuente, E.; Fernandes, M. J.; Silva, J. G.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Herrera, A. N. García; Romero, J. C. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Echeverría, J. G. Armando; Hernández, A. Ansotegui; Hualde, J. Barado; Podlepich, V.; Sokolova, E.; Alexandrova, E.; Lapteva, K.; Kurtz, P.; Shuinotsuka, C.; Rabello, L.; Vianna, G.; Reis, A.; Cairus, C.; Salluh, J.; Bozza, F.; Torres, J. C. Barrios; Araujo, N. J. Fernández; García-Olivares, P.; Keough, E.; Dalorzo, M.; Tang, L. K.; De Sousa, I.; Díaz, M.; Marcos-Zambrano, L. J.; Guerrero, J. E.; Gomez, S. E. Zamora; Lopez, G. D. Hernandez; Cuellar, A. I. Vazquez; Nieto, O. R. Perez; Gonzalez, J. A. Castanon; Bhasin, D.; Rai, S.; Singh, H.; Gupta, O.; Bhattal, M. K.; Sampley, S.; Sekhri, K.; Nandha, R.; Aliaga, F. A.; Olivares, F.; Appiani, F.; Farias, P.; Alberto, F.; Hernández, A.; Pons, S.; Sonneville, R.; Bouadma, L.; Neuville, M.; Mariotte, E.; Radjou, A.; Lebut, J.; Chemam, S.; Voiriot, G.; Dilly, M. P.; Mourvillier, B.; Dorent, R.; Nataf, P.; Wolff, M.; Timsit, J. F.; Ediboglu, O.; Ataman, S.; Ozkarakas, H.; Kirakli, C.; Vakalos, A.; Avramidis, V.; Obukhova, O.; Kurmukov, I. A.; Kashiya, S.; Golovnya, E.; Baikova, V. N.; Ageeva, T.; Haritydi, T.; Kulaga, E. V.; Rios-Toro, J. J.; Perez-Borrero, L.; Aguilar-Alonso, E.; Arias-Verdu, M. D.; Garcia-Alvarez, J. M.; Lopez-Caler, C.; De La Fuente-Martos, C.; Rodriguez-Fernandez, S.; Sanchez-Orézzoli, M. Gomez; Martin-Gallardo, F.; Nikhilesh, J.; Joshi, V.; Villarreal, E.; Ruiz, J.; Gordon, M.; Quinza, A.; Gimenez, J.; Piñol, M.; Castellanos, A.; Ramirez, P.; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Shah, H.; Kellner, F.; Rezai, F.; Mistry, N.; Yodice, P.; Ovnanian, V.; Fless, K.; Handler, E.; Alejos, R. Martínez; Romeu, J. D. Martí; Antón, D. González; Quinart, A.; Martí, A. Torres; Llaurado-Serra, M.; Lobo-Civico, A.; Ventura-Rosado, A.; Piñol-Tena, A.; Pi-Guerrero, M.; Paños-Espinosa, C.; Peralvo-Bernat, M.; Marine-Vidal, J.; Gonzalez-Engroba, R.; Montesinos-Cerro, N.; Treso-Geira, M.; Valeiras-Valero, A.; Martinez-Reyes, L.; Sandiumenge, A.; Jimenez-Herrera, M. F.; Helyar, S.; Riozzi, P.; Noon, A.; Hallows, G.; Cotton, H.; Keep, J.; Hopkins, P. A.; Taggu, A.; Renuka, S.; Sampath, S.; Rood, P. J. T.; Frenzel, T.; Verhage, R.; Bonn, M.; Pickkers, P.; van der Hoeven, J. G.; van den Boogaard, M.; Corradi, F.; Melnyk, L.; Moggia, F.; Pienovi, R.; Adriano, G.; Brusasco, C.; Mariotti, L.; Lattuada, M.; Bloomer, M. J.; Coombs, M.; Ranse, K.; Endacott, R.; Maertens, B.; Blot, K.; Blot, S.; Amerongen, M. P. van Nieuw; van der Heiden, E. S.; Twisk, J. W. R.; Girbes, A. R. J.; Spijkstra, J. J.; Riozzi, P.; Helyar, S.; Cotton, H.; Hallows, G.; Noon, A.; Bell, C.; Peters, K.; Feehan, A.; Keep, J.; Hopkins, P. A.; Churchill, K.; Hawkins, K.; Brook, R.; Paver, N.; Endacott, R.; Maistry, N.; van Wijk, A.; Rouw, N.; van Galen, T.; Evelein-Brugman, S.; Taggu, A.; Krishna, B.; Sampath, S.; Putzu, A.; Fang, M.; Berto, M. Boscolo; Belletti, A.; Cassina, T.; Cabrini, L.; Mistry, M.; Alhamdi, Y.; Welters, I.; Abrams, S. T.; Toh, C. H.; Han, H. S.; Gil, E. M.; Lee, D. S.; Park, C. M.; Winder-Rhodes, S.; Lotay, R.; Doyle, J.; Ke, M. W.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Shu, C. W.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Dubó, S.; Aquevedo, A.; Jibaja, M.; Berrutti, D.; Labra, C.; Lagos, R.; García, M. F.; Ramirez, V.; Tobar, M.; Picoita, F.; Peláez, C.; Carpio, D.; Alegría, L.; Hidalgo, C.; Godoy, K.; Bakker, J.; Hernández, G.; Sadamoto, Y.; Katabami, K.; Wada, T.; Ono, Y.; Maekawa, K.; Hayakawa, M.; Sawamura, A.; Gando, S.; Marin-Mateos, H.; Perez-Vela, J. L.; Garcia-Gigorro, R.; Peiretti, M. A. Corres; Lopez-Gude, M. J.; Chacon-Alves, S.; Renes-Carreño, E.; Montejo-González, J. C.; Parlevliet, K. L.; Touw, H. R. W.; Beerepoot, M.; Boer, C.; Elbers, P. W. G.; Tuinman, P. R.; Abdelmonem, S. A.; Helmy, T. A.; El Sayed, I.; Ghazal, S.; Akhlagh, S. H.; Masjedi, M.; Hozhabri, K.; Kamali, E.; Zýková, I.; Paldusová, B.; Sedlák, P.; Morman, D.; Youn, A. M.; Ohta, Y.; Sakuma, M.; Bates, D.; Morimoto, T.; Su, P. L.; Chang, W. Y.; Lin, W. C.; Chen, C. W.; Facchin, F.; Zarantonello, F.; Panciera, G.; De Cassai, A.; Venrdramin, A.; Ballin, A.; Tonetti, T.; Persona, P.; Ori, C.; Del Sorbo, L.; Rossi, S.; Vergani, G.; Cressoni, M.; Chiumello, D.; Chiurazzi, C.; Brioni, M.; Algieri, I.; Tonetti, T.; Guanziroli, M.; Colombo, A.; Tomic, I.; Colombo, A.; Crimella, F.; Carlesso, E.; Gasparovic, V.; Gattinoni, L.; Neto, A. Serpa; Schmidt, M.; Pham, T.; Combes, A.; de Abreu, M. Gama; Pelosi, P.; Schultz, M. J.; Katira, B. H.; Engelberts, D.; Giesinger, R. E.; Ackerley, C.; Yoshida, T.; Zabini, D.; Otulakowski, G.; Post, M.; Kuebler, W. M.; McNamara, P. J.; Kavanagh, B. P.; Pirracchio, R.; Rigon, M. Resche; Carone, M.; Chevret, S.; Annane, D.; Eladawy, S.; El-Hamamsy, M.; Bazan, N.; Elgendy, M.; De Pascale, G.; Vallecoccia, M. S.; Cutuli, S. L.; Di Gravio, V.; Pennisi, M. A.; Conti, G.; Antonelli, M.; Andreis, D. T.; Khaliq, W.; Singer, M.; Hartmann, J.; Harm, S.; Carmona, S. Alcantara; Almudevar, P. Matia; Abellán, A. Naharro; Ramos, J. Veganzones; Pérez, L. Pérez; Valbuena, B. Lobo; Sanz, N. Martínez; Simón, I. Fernández; Arrigo, M.; Feliot, E.; Deye, N.; Cariou, A.; Guidet, B.; Jaber, S.; Leone, M.; Resche-Rigon, M.; Baron, A. Vieillard; Legrand, M.; Gayat, E.; Mebazaa, A.; Balik, M.; Kolnikova, I.; Maly, M.; Waldauf, P.; Tavazzi, G.; Kristof, J.; Herpain, A.; Su, F.; Post, E.; Taccone, F.; Vincent, J. L.; Creteur, J.; Lee, C.; Hatib, F.; Jian, Z.; Buddi, S.; Cannesson, M.; Fileković, S.; Turel, M.; Knafelj, R.; Gorjup, V.; Stanić, R.; Gradišek, P.; Cerović, O.; Mirković, T.; Noč, M.; Tirkkonen, J.; Hellevuo, H.; Olkkola, K. T.; Hoppu, S.; Lin, K. C.; Hung, W. T.; Chiang, C. C.; Huang, W. C.; Juan, W. C.; Lin, S. C.; Cheng, C. C.; Lin, P. H.; Fong, K. Y.; Hou, D. S.; Kang, P. L.; Wann, S. R.; Chen, Y. S.; Mar, G. Y.; Liu, C. P.; Paul, M.; Bougouin, W.; Geri, G.; Dumas, F.; Champigneulle, B.; Legriel, S.; Charpentier, J.; Mira, J. P.; Sandroni, C.; Cariou, A.; Zimmerman, J.; Sullivan, E.; Noursadeghi, M.; Fox, B.; Sampson, D.; McHugh, L.; Yager, T.; Cermelli, S.; Seldon, T.; Bhide, S.; Brandon, R. A.; Brandon, R. B.; Zwaag, J.; Beunders, R.; Pickkers, P.; Kox, M.; Gul, F.; Arslantas, M. K.; Genc, D.; Zibandah, N.; Topcu, L.; Akkoc, T.; Cinel, I.; Greco, E.; Lauretta, M. P.; Andreis, D. T.; Singer, M.; Garcia, I. Palacios; Cordero, M.; Martin, A. Diaz; Pallás, T. Aldabó; Montero, J. Garnacho; Rey, J. Revuelto; Malo, L. Roman; Montoya, A. A. Tanaka; Martinez, A. D. C. Amador; Ayala, L. Y. Delgado; Zepeda, E. Monares; Granillo, J. Franco; Sanchez, J. Aguirre; Alejo, G. Camarena; Cabrera, A. Rugerio; Montenegro, A. Pedraza; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Soilemezi, E.; Koco, E.; Savvidou, S.; Nouris, C.; Matamis, D.; Di Mussi, R.; Spadaro, S.; Volta, C. A.; Mariani, M.; Colaprico, A.; Antonio, C.; Bruno, F.; Grasso, S.; Rodriguez, A.; Martín-Loeches, I.; Díaz, E.; Masclans, J. R.; Gordo, F.; Solé-Violán, J.; Bodí, M.; Avilés-Jurado, F. X.; Trefler, S.; Magret, M.; Reyes, L. F.; Marín-Corral, J.; Yebenes, J. C.; Esteban, A.; Anzueto, A.; Aliberti, S.; Restrepo, M. I.; Larsson, J. Skytte; Redfors, B.; Ricksten, S. E.; Haines, R.; Powell-Tuck, J.; Leonard, H.; Ostermann, M.; Berthelsen, R. E.; Itenov, T. S.; Perner, A.; Jensen, J. U.; Ibsen, M.; Jensen, A. E. K.; Bestle, M. H.; Bucknall, T.; Dixon, J.; Boa, F.; MacPhee, I.; Philips, B. J.; Doyle, J.; Saadat, F.; Samuels, T.; Huddart, S.; McCormick, B.; DeBrunnar, R.; Preece, J.; Swart, M.; Peden, C.; Richardson, S.; Forni, L.; Kalfon, P.; Baumstarck, K.; Estagnasie, P.; Geantot, M. A.; Berric, A.; Simon, G.; Floccard, B.; Signouret, T.; Boucekine, M.; Fromentin, M.; Nyunga, M.; Sossou, A.; Venot, M.; Robert, R.; Follin, A.; Renault, A.; Garrouste, M.; Collange, O.; Levrat, Q.; Villard, I.; Thévenin, D.; Pottecher, J.; Patrigeon, R. G.; Revel, N.; Vigne, C.; Mimoz, O.; Auquier, P.; Pawar, S.; Jacques, T.; Deshpande, K.; Pusapati, R.; Wood, B.; Pulham, R. A.; Wray, J.; Brown, K.; Pierce, C.; Nadel, S.; Ramnarayan, P.; Azevedo, J. R.; Montenegro, W. S.; Rodrigues, D. P.; Sousa, S. C.; Araujo, V. F.; Leitao, A. L.; Prazeres, P. H.; Mendonca, A. V.; Paula, M. P.; Das Neves, A.; Loudet, C. I.; Busico, M.; Vazquez, D.; Villalba, D.; Lischinsky, A.; Veronesi, M.; Emmerich, M.; Descotte, E.; Juliarena, A.; Bisso, M. Carboni; Grando, M.; Tapia, A.; Camargo, M.; Ulla, D. Villani; Corzo, L.; dos Santos, H. Placido; Ramos, A.; Doglia, J. A.; Estenssoro, E.; Carbonara, M.; Magnoni, S.; Donald, C. L. Mac; Shimony, J. S.; Conte, V.; Triulzi, F.; Stretti, F.; Macrì, M.; Snyder, A. Z.; Stocchetti, N.; Brody, D. L.; Podlepich, V.; Shimanskiy, V.; Savin, I.; Lapteva, K.; Chumaev, A.; Tjepkema-Cloostermans, M. C.; Hofmeijer, J.; Beishuizen, A.; Hom, H.; Blans, M. J.; van Putten, M. J. A. M.; Longhi, L.; Frigeni, B.; Curinga, M.; Mingone, D.; Beretta, S.; Patruno, A.; Gandini, L.; Vargiolu, A.; Ferri, F.; Ceriani, R.; Rottoli, M. R.; Lorini, L.; Citerio, G.; Pifferi, S.; Battistini, M.; Cordolcini, V.; Agarossi, A.; Di Rosso, R.; Ortolano, F.; Stocchetti, N.; Lourido, C. Mora; Cabrera, J. L. Santana; Santana, J. D. Martín; Alzola, L. Melián; del Rosario, C. García; Pérez, H. Rodríguez; Torrent, R. Lorenzo; Eslami, S.; Dalhuisen, A.; Fiks, T.; Schultz, M. J.; Hanna, A. Abu; Spronk, P. E.; Wood, M.; Maslove, D.; Muscedere, J.; Scott, S. H.; Saha, T.; Hamilton, A.; Petsikas, D.; Payne, D.; Boyd, J. G.; Puthucheary, Z. A.; McNelly, A. S.; Rawal, J.; Connolly, B.; McPhail, M. J.; Sidhu, P.; Rowlerson, A.; Moxham, J.; Harridge, S. D.; Hart, N.; Montgomery, H. E.; Jovaisa, T.; Thomas, B.; Gupta, D.; Wijayatilake, D. S.; Shum, H. P.; King, H. S.; Chan, K. C.; Tang, K. B.; Yan, W. W.; Arias, C. Castro; Latorre, J.; De La Rica, A. Suárez; Garrido, E. Maseda; Feijoo, A. Montero; Gancedo, C. Hernández; Tofiño, A. López; Rodríguez, F. Gilsanz; Gemmell, L. K.; Campbell, R.; Doherty, P.; MacKay, A.; Singh, N.; Vitaller, S.; Nagib, H.; Prieto, J.; Del Arco, A.; Zayas, B.; Gomez, C.; Tirumala, S.; Pasha, S. A.; Kumari, B. K.; Martinez-Lopez, P.; Puerto-Morlán, A.; Nuevo-Ortega, P.; Pujol, L. Martinez; Dolset, R. Algarte; González, B. Sánchez; Riera, S. Quintana; Álvarez, J. Trenado; Quintana, S.; Martínez, L.; Algarte, R.; Sánchez, B.; Trenado, J.; Tomas, E.; Brock, N.; Viegas, E.; Filipe, E.; Cottle, D.; Traynor, T.; Martínez, M. V. Trasmonte; Márquez, M. Pérez; Gómez, L. Colino; Martínez, N. Arias; Muñoz, J. M. Milicua; Bellver, B. Quesada; Varea, M. Muñoz; Llorente, M. Á. Alcalá; Calvo, C. Pérez; Hillier, S. D.; Faulds, M. C.; Hendra, H.; Lawrence, N.; Maekawa, K.; Hayakawa, M.; Ono, Y.; Kodate, A.; Sadamoto, Y.; Tominaga, N.; Mizugaki, A.; Murakami, H.; Yoshida, T.; Katabami, K.; Wada, T.; Sawamura, A.; Gando, S.; Silva, S.; Kerhuel, L.; Malagurski, B.; Citerio, G.; Chabanne, R.; Laureys, S.; Puybasset, L.; Nobile, L.; Pognuz, E. R.; Rossetti, A. O.; Verginella, F.; Gaspard, N.; Creteur, J.; Ben-Hamouda, N.; Oddo, M.; Taccone, F. 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H.; Oh, J.; Choi, K. S.; Jang, B. H.; Ha, J. K.; Mecklenburg, A.; Stamm, J.; Soeffker, G.; Kubik, M.; Sydow, K.; Reichenspurner, H.; Kluge, S.; Braune, S.; Bergantino, B.; Ruberto, F.; Magnanimi, E.; Privato, E.; Zullino, V.; Bruno, K.; Pugliese, F.; Sales, G.; Girotto, V.; Vittone, F.; Brazzi, L.; Fritz, C.; Kimmoun, A.; Vanhuyse, F.; Trifan, B.; Orlowski, S.; Albuisson, E.; Tran, N.; Levy, B.; Chhor, V.; Joachim, J.; Follin, A.; Champigneulle, B.; Chatelon, J.; Fave, G.; Mantz, J.; Pirracchio, R.; Diaz, D. Díaz; Villanova, M.; Aguirregabyria, M.; Andrade, G.; López, L.; Palencia, E.; John, G.; Cowan, R.; Hart, R.; Lake, K.; Litchfield, K.; Song, J. W.; Lee, Y. J.; Cho, Y. J.; Choi, S.; Vermeir, P.; Vandijck, D.; Blot, S.; Mariman, A.; Verhaeghe, R.; Deveugele, M.; Vogelaers, D.; Chok, L.; Bachli, E. B.; Bettex, D.; Cottini, S. R.; Keller, E.; Maggiorini, M.; Schuepbach, R.; Fiks, T.; Stiphout, C.; Grevelink, M.; Vaneker, I.; Ruijter, A.; Buise, M.; Spronk, P. E.; Tena, S. 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K.; Ruffini, C.; Rota, L.; Corona, A.; Sesana, G.; Ravasi, S.; Catena, E.; Naumann, D. N.; Mellis, C.; Husheer, S. L.; Bishop, J.; Midwinter, M. J.; Hutchings, S.; Corradi, F.; Brusasco, C.; Manca, T.; Ramelli, A.; Lattuada, M.; Nicolini, F.; Gherli, T.; Vezzani, A.; Young, A.; Carmona, A. Fernández; Santiago, A. Iglesias; Guillamon, L. Navarro; Delgado, M. J. García; Delgado-Amaya, M.; Curiel-Balsera, E.; Rivera-Romero, L.; Castillo-Lorente, E.; Carrero-Gómez, F.; Aguayo-DeHoyos, E.; Healey, A. J.; Cameron, C.; Jiao, L.R.; Stümpfle, R.; Pérez, A.; Martin, S.; del Moral, O. Lopez; Toval, S.; Rico, J.; Aldecoa, C.; Oguzhan, K.; Demirkiran, O.; Kirman, M.; Bozbay, S.; Kosuk, M. E.; Asyralyyeva, G.; Dilek, M.; Duzgun, M.; Telli, S.; Aydin, M.; Yilmazer, F.; Hodgson, L. E.; Dimitrov, B. D.; Stubbs, C.; Forni, L. G.; Venn, R.; Vedage, D.; Shawaf, S.; Naran, P.; Sirisena, N.; Kinnear, J.; Dimitrov, B. D.; Hodgson, L. E.; Stubbs, C.; Forni, L. G.; Venn, R.; Londoño, J. Gonzalez; Cardenas, C. 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K.; Makiko, S.; Tsunoda, M.; Kang, M.; Yuzawa, J.; Akiduki, N.; Namiki, M.; Takeda, M.; Yaguchi, A.; Preau, S.; Ambler, M.; Sigurta, A.; Saeed, S.; Singer, M.; Jochmans, S.; Chelly, J.; Vong, L. V. P.; Sy, O.; Serbource-Goguel, J.; Rolin, N.; Weyer, C. M.; Abdallah, R. I.; Adrie, C.; Vinsonneau, C.; Monchi, M.; Mayr, U.; Huber, W.; Karsten, E.; Lahmer, T.; Thies, P.; Henschel, B.; Fischer, G.; Schmid, R. M.; Ediboglu, O.; Ataman, S.; Naz, I.; Yaman, G.; Kirakli, C.; Su, P. L.; Kou, P. S.; Lin, W. C.; Chen, C. W.; Lozano, J. A. Benítez; Sánchez, P. Carmona; Francioni, J. E. Barrueco; Ferrón, F. Ruiz; Simón, J. M. Serrano; Riad, Z.; Mezidi, M.; Aublanc, M.; Perinel, S.; Lissonde, F.; Louf-Durier, A.; Yonis, H.; Tapponnier, R.; Richard, J. C.; Louis, B.; Guérin, C.; Mezidi, M.; Yonis, H.; Aublanc, M.; Lissonde, F.; Louf-Durier, A.; Perinel, S.; Tapponnier, R.; Richard, J. C.; Guérin, C.; Marmanidou, K.; Oikonomou, M.; Nouris, C.; Loizou, C.; Soilemezi, E.; Matamis, D.; Somhorst, P.; Gommers, D.; Hayashi, K.; Hirayama, T.; Yumoto, T.; Tsukahara, K.; Iida, A.; Nosaka, N.; Sato, K.; Ugawa, T.; Nakao, A.; Ujike, Y.; Hirohata, S.; Mojoli, F.; Torriglia, F.; Giannantonio, M.; Orlando, A.; Bianzina, S.; Tavazzi, G.; Mongodi, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Jansen, D.; Gadgil, S.; Doorduin, J.; Roesthuis, L.; van der Hoeven, J. G.; Heunks, L. M. A.; Chen, G. Q.; Sun, X. M.; He, X.; Yang, Y. L.; Shi, Z. H.; Xu, M.; Zhou, J. X.; Pereira, S. M.; Tucci, M. R.; Tonelotto, B. F. F.; Simoes, C. M.; Morais, C. C. A.; Pompeo, M. S.; Kay, F. U.; Amato, M. B. P.; Vieira, J. E.; Suzuki, S.; Mihara, Y.; Hikasa, Y.; Okahara, S.; Morimatsu, H.; Kwon, H. M.; Moon, Y. J.; Lee, S. H.; Jung, K. W.; Shin, W. J.; Jun, I. G.; Song, J. G.; Hwang, G. S.; Lee, S.; Moon, Y. J.; Kwon, H. M.; Jung, K.; Shin, W. J.; Jun, I. G.; Song, J. G.; Hwang, G. 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Ruiz del Portal-Ruiz; Faivre, V.; Wildenberg, L.; Huot, B.; Lukaszewicz, A. C.; Simsir, M.; Mengelle, C.; Payen, D.; Sanz, N. Martinez; Valbuena, B. Lobo; de la Fuente, M. Valdivia; Almudena, P. Matía; Pérez, L. Pérez; Carmona, S. Alcántara; Abellán, A. Navarro; Simón, I. Fernández; Muñoz, J. J. Rubio; Ramos, J. Veganzones; Carmona, S. Alcantara; Almudevar, P. Matia; Abellan, A. Naharro; Lucendo, M. A. Perez; Perez, L. Perez; Dominguez, J. Palamidessi; Rivas, R. Fernandez; Villamizar, P. Rodriguez; Wee, S.; Ong, C.; Lau, Y. H.; Wong, Y.; Banderas-Bravo, M. E.; Olea-Jiménez, V.; Mora-Ordóñez, J. M.; Gómez-Jiménez, C.; Muñoz-Muñoz, J. L.; Vallejo-Báez, J.; Daga-Ruiz, D.; Lebrón-Gallardo, M.; Rialp, G.; Raurich, J. M.; Morán, I.; Martín, M. C.; Heras, G.; Mas, A.; Vallverdú, I.; Hraiech, S.; Bourenne, J.; Guervilly, C.; Forel, J. M.; Adda, M.; Sylla, P.; Mouaci, A.; Gainnier, M.; Papazian, L.; Bauer, P. R.; Kumbamu, A.; Wilson, M. E.; Pannu, J. K.; Egginton, J. S.; Kashyap, R.; Gajic, O.; Yoshihiro, S.; Sakuraya, M.; Hayakawa, M.; Hirata, A.; Kawamura, N.; Tsutui, T.; Yoshida, K.; Hashimoto, Y.; Chang, C. H.; Hu, H. C.; Chiu, L. C.; Hung, C. Y.; Li, S. H.; Kao, K. C.; Sibley, S.; Drover, J.; D’Arsigny, C.; Parker, C.; Howes, D.; Moffatt, S.; Erb, J.; Ilan, R.; Messenger, D.; Ball, I.; Boyd, J. G.; Harrison, M.; Ridi, S.; Muscedere, J.; Andrade, A. H.; Costa, R. C.; Souza, V. A.; Gonzalez, V.; Amorim, V.; Rolla, F.; Filho, C. A. C. Abreu; Miranda, R.; Atchasiri, S.; Buranavanich, P.; Wathanawatthu, T.; Suwanpasu, S.; Bureau, C.; Rolland-Debord, C.; Poitou, T.; Clavel, M.; Perbet, S.; Terzi, N.; Kouatchet, A.; Similowski, T.; Demoule, A.; Diaz, P.; Nunes, J.; Escórcio, S.; Silva, G.; Chaves, S.; Jardim, M.; Câmara, M.; Fernandes, N.; Duarte, R.; Jardim, J. J.; Pereira, C. A.; Nóbrega, J. J.; Chen, C. M.; Lai, C. C.; Cheng, K. C.; Chou, W.; Lee, S. J.; Cha, Y. S.; Lee, W. Y.; Onodera, M.; Nakataki, E.; Oto, J.; Imanaka, H.; Nishimura, M.; Khadjibaev, A.; Sabirov, D.; Rosstalnaya, A.; Akalaev, R.; Parpibaev, F.; Antonucci, E.; Rossini, P.; Gandolfi, S.; Montini, E.; Orlando, S.; van Nes, M.; Karachi, F.; Hanekom, S.; Andrade, A. H.; Pereira, U. V.; Filho, C. A. C. Abreu; Costa, R. C.; Parkin, M. S. W.; Moore, M.; Andrade, A. H.; Costa, R. C.; Carvalho, K. V. Silva; Filho, C. A. C. Abreu; Min, H. J.; Kim, H. J.; Lee, D. S.; Choi, Y. Y.; Lee, E. Y.; Song, I.; Kim, D. J.; E, Y. Y.; Kim, J. W.; Park, J. S.; Cho, Y. J.; Lee, J. H.; Suh, J. W.; Jo, Y. H.; Kim, K. S.; Lee, Y. J.; Ferrero-Calleja, J.; Merino-Vega, D.; González-Jiménez, A. I.; Sigcha, M. Sigcha; Hernández-Tejedor, A.; Martin-Vivas, A.; Gabán-Díez, Á.; Luna, R. Ruiz-de; De la Calle-Pedrosa, N.; Temprano-Gómez, I.; Afonso-Rivero, D.; Pellin-Ariño, J. I.; Algora-Weber, A.; Fumis, R. R. L.; Ferraz, A. B.; Junior, J. M. Vieira; Kirca, H.; Cakin, O.; Unal, M.; Mutlu, H.; Ramazanoglu, A.; Cengiz, M.; Nicolini, E. A.; Pelisson, F. G. F.; Nunes, R. S.; da Silva, S. L.; Carreira, M. M.; Bellissimo-Rodrigues, F.; Ferez, M. A.; Basile-Filho, A.; Chao, H. C.; Chen, C. M.; Chen, L.; Hravnak, M.; Clermont, G.; Pinsky, M.; Dubrawski, A.; Varas, J. Luján; Montero, R. Molina; Sánchez-Elvira, L. Alcázar; Díaz, P. Villa; Delgado, C. Pintado; Ruiz, B. Llorente; Guerrero, A. Pardo; Galache, J. A. Cambronero; Sherif, H.; Hassanin, H.; El Hossainy, R.; Samy, W.; Ly, H.; David, H.; Burtin, P.; Charpentier, C.; Barral, M.; Courant, P.; Fournel, E.; Gaide-Chevronnay, L.; Durand, M.; Albaladejo, P.; Payen, J. F.; Chavanon, O.; Ortiz, A. Blandino; Pozzebon, S.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Fumagalli, F.; Scala, S.; Affatato, R.; De Maglie, M.; Zani, D.; Novelli, D.; Marra, C.; Luciani, A.; De Zani, D.; Luini, M.; Letizia, T.; Pravettoni, D.; Staszewsky, L.; Masson, S.; Belloli, A.; Di Giancamillo, M.; Scanziani, E.; Latini, R.; Ristagno, G.; Kye, Y. C.; Suh, G. J.; Kwon, W. Y.; Kim, K. S.; Yu, K. M.; Babini, G.; Ristagno, G.; Grassi, L.; Fumagalli, F.; Bendel, S.; De Maglie, M.; Affatato, R.; Masson, S.; Latini, R.; Scanziani, E.; Reinikainen, M.; Skrifvars, M.; Kappler, F.; Blobner, M.; Schaller, S. J.; Roasio, A.; Costanzo, E.; Cardellino, S.; Iesu, E.; Cavicchi, F. Zama; Fontana, V.; Nobile, L.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Park, M.; You, K. M.; Suh, G. J.; Kwon, W. Y.; Ko, S. B.; Kim, K. S.; Xini, A.; Marca, L.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Beane, A.; Thilakasiri, M. C. K. T.; De Silva, A. P.; Stephens, T.; Sigera, C. S.; Athapattu, P.; Jayasinghe, S.; Padeniya, A.; Haniffa, R.; Santiago, A. Iglesias; Sáez, V. Chica; Ruiz-Ruano, R. de la Chica; González, A. Sánchez; Kunze-Szikszay, N.; Wand, S.; Klapsing, P.; Wetz, A.; Heyne, T.; Schwerdtfeger, K.; Troeltzsch, M.; Bauer, M.; Quintel, M.; Moerer, O.; Cook, D. J.; Rutherford, W. B.; Scales, D. C.; Adhikari, N. K.; Cuthbertson, B. H.; Suzuki, T.; Takei, T.; Fushimi, K.; Iwamoto, M.; Nakagawa, S.; Mendsaikhan, N.; Begzjav, T.; Lundeg, G.; Dünser, M. W.; Romero, D. González; Cabrera, J. L. Santana; Santana, J. D. Martín; Padilla, Y. Santana; Pérez, H. Rodríguez; Torrent, R. Lorenzo; Kleinpell, R.; Chouris, I.; Radu, V.; Stougianni, M.; Lavrentieva, A.; Lagonidis, D.; Price, R. D. T.; Day, A.; Arora, N.; Henderson, M. A.; Hickey, S.; Costa, M. I. Almeida; Carvalho, J. P.; Gomes, A. A.; Mergulhão, P. J.; Chan, K. K. C.; Shum, H. P.; Yan, W. W.; Maghsoudi, B.; Tabei, S. H.; Masjedi, M.; Sabetian, G.; Tabatabaei, H. R.; Akbarzadeh, A.; Saigal, S.; Pakhare, A.; Joshi, R.; Pattnaik, S. K.; Ray, B.; Rousseau, A. F.; Michel, L.; Bawin, M.; Cavalier, E.; Reginster, J. Y.; Damas, P.; Bruyere, O.; Zhou, J. C.; Cauwenberghs, H.; De Backer, A.; Neels, H.; Deblier, I.; Berghmans, J.; Himpe, D.; Barea-Mendoza, J. A.; Portillo, I. Prieto; Fernández, M. Valiente; Gigorro, R. Garcia; Vela, J. L. Perez; Mateos, H. Marín; Alves, S. Chacón; Varas, G. Morales; Rodriguez-Biendicho, A.; Carreño, E. Renes; González, J. C. Montejo; Yang, J. S.; Chiang, C. H.; Hung, W. T.; Huang, W. C.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Lin, K. L.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Zhou, J. C.; Choi, Y. J.; Yoon, S. Z.; Gordillo-Brenes, A.; Fernandez-Zamora, M. D.; Perez-Borrero, L.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Herruzo-Aviles, A.; Garcia-Delgado, M.; Hinojosa-Perez, R.; Curiel-Balsera, E.; Rivera-Fernandez, R.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Herrera, A. N. García; Sanz, E. Regidor; Sánchez, M. J. Gómez; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Irazabal, J. M. Guergue; Pérez, A. González; Fernández, P. Alvarez; Amor, L. Lopéz; Albaiceta, G. Muñiz; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Sanz, E. Regidor; Sánchez, M. J. Gómez; Calvo, S. Aldunate; Herrera, A. N. García; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Corona, A.; Ruffini, C.; Spazzadeschi, A.; Marrazzo, F.; Gandola, A.; Sciurti, R.; Savi, C.; Catena, E.; Ke, M. W.; Cheng, C. C.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Lin, K. C.; Lin, S. C.; Wann, S. R.; Chiou, K. R.; Tseng, C. J.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Bertini, P.; De Sanctis, F.; Guarracino, F.; Bertini, P.; Baldassarri, R.; Guarracino, F.; Buitinck, S. H.; van der Voort, P. H. J.; Oto, J.; Nakataki, E.; Tsunano, Y.; Izawa, M.; Tane, N.; Onodera, M.; Nishimura, M.; Ghosh, S.; Gupta, A.; De Gasperi, A.; Mazza, E.; Limuti, R.; Prosperi, M.; Bissenova, N.; Yergaliyeva, A.; Talan, L.; Yılmaz, G.; Güven, G.; Yoruk, F.; Altıntas, N. D.; Mukherjee, D. N.; Agarwal, L. K.; Mandal, K.; Palomar, M.; Balsera, B.; Vallverdu, M.; Martinez, M.; Garcia, M.; Castellana, D.; Lopez, R.; Barcenilla, F.; Kaminsky, G. E.; Carreño, R.; Escribá, A.; Fuentes, M.; Gálvez, V.; Del Olmo, R.; Nieto, B.; Vaquerizo, C.; Alvarez, J.; De la Torre, M. A.; Torres, E.; Bogossian, E.; Nouer, S. Aranha; Salgado, D. Ribeiro; Brugger, S. Carvalho; Jiménez, G. Jiménez; Torner, M. Miralbés; Vidal, M. Vallverdú; Garrido, B. Balsera; Casals, X. Nuvials; Gaite, F. Barcenilla; Cabello, J. Trujillano; Martínez, M. Palomar; Doganci, M.; Izdes, S.; Besevli, S. Guzeldag; Alkan, A.; Kayaaslan, B.; Ramírez, C. Sánchez; Balcázar, L. Caipe; Santana, M. Cabrera; Viera, M. A. Hernández; Escalada, S. Hípola; Vázquez, C. F. Lübbe; Penichet, S. M. Marrero; Campelo, F. Artiles; López, M. A. De La Cal; Santana, P. Saavedra; Santana, S. Ruíz; Repessé, X.; Artiguenave, M.; Paktoris-Papine, S.; Espinasse, F.; Dinh, A.; El Sayed, F.; Charron, C.; Géri, G.; Vieillard-Baron, A.; Marmanidou, K.; Oikonomou, M.; Nouris, C.; Dimitroulakis, K.; Soilemezi, E.; Matamis, D.; Ferré, A.; Guillot, M.; Teboul, J. L.; Lichtenstein, D.; Mézière, G.; Richard, C.; Monnet, X.; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Prīdāne, S.; Sabeļņikovs, O.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Beduneau, G.; Pham, T.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Kondili, E.; Psarologakis, C.; Kokkini, S.; Amargianitakis, V.; Babalis, D.; Chytas, A.; Chouvarda, I.; Vaporidi, K.; Georgopoulos, D.; Trapp, O.; Kalenka, A.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Lozano, J. A. Benítez; Sánchez, P. Carmona; Francioni, J. E. Barrueco; Ferrón, F. Ruiz; Simón, J. M. Serrano; Spadaro, S.; Karbing, D. S.; Gioia, A.; Moro, F.; Corte, F. Dalla; Mauri, T.; Volta, C. A.; Rees, S. E.; Petrova, M. V.; Mohan, R.; Butrov, A. V.; Beeharry, S. D.; Vatsik, M. V.; Sakieva, F. I.; Gobert, F.; Yonis, H.; Tapponnier, R.; Fernandez, R.; Labaune, M. A.; Burle, J. F.; Barbier, J.; Vincent, B.; Cleyet, M.; Richard, J. C.; Guérin, C.; Shinotsuka, C. Righy; Creteur, J.; Taccone, F. S.; Törnblom, S.; Nisula, S.; Vaara, S.; Poukkanen, M.; Andersson, S.; Pettilä, V.; Pesonen, E.; Xie, Z.; Liao, X.; Kang, Y.; Zhang, J.; Kubota, K.; Egi, M.; Mizobuchi, S.; Hegazy, S.; El-Keraie, A.; El Sayed, E.; El Hamid, M. Abd; Rodrigues, N. J.; Pereira, M.; Godinho, I.; Gameiro, J.; Neves, M.; Gouveia, J.; e Silva, Z. Costa; Lopes, J. A.; Mckinlay, J.; Kostalas, M.; Kooner, G.; Dudas, G.; Horton, A.; Kerr, C.; Karanjia, N.; Creagh-Brown, B.; Forni, L.; Yamazaki, A.; Ganuza, M. Sanz; Molina, J. A. Martinez; Martinez, F. Hidalgo; Freile, M. T. Chiquito; Fernandez, N. Garcia; Travieso, P. Medrano; Bandert, A.; Frithiof, R.; Lipcsey, M.; Smekal, D.; Schlaepfer, P.; Durovray, J. D.; Plouhinec, V.; Chiappa, C.; Bellomo, R.; Schneider, A. G.; Mitchell, S.; Durrant, J.; Street, H.; Dunthorne, E.; Shears, J.; Caballero, C. Hernandez; Hutchison, R.; Schwarze, S.; Ghabina, S.; Thompson, E.; Prowle, J. R.; Kirwan, C. J.; Gonzalez, C. A.; Pinto, J. L.; Orozco, V.; Patiño, J. A.; Garcia, P. K.; Contreras, K. M.; Rodriguez, P.; Echeverri, J. E. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 journal: Intensive Care Med Exp DOI: 10.1186/s40635-016-0100-7 sha: doc_id: 14533 cord_uid: 6qfecv5h nan months is better than Cole's formula. keywords: acute; admission; adult patients; age; aki; analysis; ards patients; arrest; blood; c. a.; c. c.; c. m.; cardiac; care; care patients; care unit; cases; clinical; complications; conclusions; control; criteria; data; days; death; differences; discharge; duration; end; factors; failure; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increased; infection; injury; intensive; introduction; j. a.; j. c.; j. e.; j. f.; j. g.; j. j.; j. l.; j. m.; j. p.; j. s.; length; level; lung; m. a.; m. d.; m. e.; m. m.; mean; median; medical; methods; mortality; non; number; objectives; organ; outcome; p =; patients; peep; period; post; pressure; quality; rate; results; resuscitation; risk; s. c.; s. m.; score; sepsis; septic; shock; standard; stay; study; surgery; surgical; survival; system; test; therapy; time; total; treatment; unit; use; value; ventilation; volume; weaning; y. j.; years cache: cord-014533-6qfecv5h.txt plain text: cord-014533-6qfecv5h.txt item: #281 of 2876 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61107 flesch: 45 summary: We included ICU patients admitted for acute hypoxemic respiratory failure from a previous prospective trial [1] in whom FiO 2 was measured under oxygen mask using a portable oxygen analyzer. Introduction Relative adrenal insufficiency (RAI) is common in ICU patients, particularly during septic shock (1). keywords: acute; admission; adult patients; age; aim; analysis; ards patients; arrest; blood; cardiac; care; care unit; cases; cause; children; clinical; conclusion; criteria; data; days; diagnosis; discussion; disease; duration; extubation; factors; failure; fluid; group; hospital; icu; icu admission; icu mortality; icu patients; incidence; infection; injury; intensive; introduction; jean; low; lung; management; mean; mechanical; median; medical; methods; mortality; n =; niv; non; nutrition; occurrence; outcome; oxygen; p =; patients; period; pierre; pneumonia; pressure; pulmonary; rate; renal; results; risk; score; sepsis; shock; shock patients; significant; stay; studies; study; study period; support; syndrome; therapy; time; treatment; unit; use; vap; ventilation; weaning; years cache: cord-014538-6a2pviol.txt plain text: cord-014538-6a2pviol.txt item: #282 of 2876 id: cord-014540-27hnlu5v author: Sutthiruk, Nantanit title: Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC): Bangkok, Thailand. 12-15 February 2017 date: 2017-02-22 words: 24575 flesch: 43 summary: Following the interventions, environmental cleaning assessment of high-touch areas showed an overall average of 86% compliance, with 17 CB-DCs achieving ≥85% compliance in environmental cleaning of high-touch areas. However, in some cases, the difference between S. aureus from different MLST types were much lower -28% (ST239-ST609), 14% (ST8-ST239), 11% (ST8-ST609) and 5% (ST5-ST105). keywords: 6(suppl; antibiotic; associated; background; blood; care; cases; chen; cleaning; compliance; contamination; control; data; days; dose; hand; hand hygiene; hcws; healthcare; hospital; hygiene; incidence; infection; infection control; intervention; isolates; medical; methods; mrsa; nurses; patients; practice; prevention; process; program; rate; resistance; results; risk; ssi; staff; study; system; test; total; treatment; use; vap; workers; years cache: cord-014540-27hnlu5v.txt plain text: cord-014540-27hnlu5v.txt item: #283 of 2876 id: cord-014670-e31g8lns author: None title: Poster Sessions 313-503 date: 2004-10-05 words: 28600 flesch: 52 summary: We develop a systematic data collection of all the admitted patients in our ICU through a home-made software and database leading to a broad description of the population and activities of the ICU during the last five years; this was correlated with the classical scoring systems of ICU patients. At the first session, the participants were proposed to imagine a situation starting from one of 2 pictures of ICU patient. keywords: acute; admission; age; analysis; blood; brain; cardiac; care; data; days; dose; dysfunction; failure; fluid; group; hospital; hours; icu; injury; intensive; level; lung; mean; medical; min; mortality; non; outcome; parameters; patients; period; pressure; pts; rate; ratio; results; score; sepsis; septic; stay; study; surgery; system; therapy; treatment; unit; university; use; values; ventilation; volume cache: cord-014670-e31g8lns.txt plain text: cord-014670-e31g8lns.txt item: #284 of 2876 id: cord-014687-0am4l5ms author: None title: SPR 2012 date: 2012-03-29 words: 98702 flesch: 39 summary: Image Gently has succeeded not only in raising awareness of the great diagnostic benefits we can offer to pediatric patients but also directs us to acknowledge the downside of overzealous diagnostic efforts where excessive radiation becomes a risk. Methods & Materials: Pediatric patients who had high temporal resolution cine Steady State Free Precession sequence (50 frames acquired across a single cardiac cycle) performed as part of a MRI/MRA of the heart from 2005-2011 were included. keywords: abnormalities; acute; age; airway; anatomy; anomalies; appearance; approach; assessment; average; blood; body; bone; bowel; brain; brain mri; cardiac; care; case report; cases; center; chest; children; complications; conclusions; conditions; contrast; correlation; ct imaging; data; days; development; diagnosis; diffusion; disease; disorders; dose; evaluation; exhibit; fat; fetal; flow; follow; following; fractures; group; head; heart; high; hospital; images; imaging; imaging features; imaging findings; imaging modalities; imaging studies; infants; information; injury; institution; left; lesions; level; literature; liver; low; lung; malformations; management; mass; masses; materials; mean; medical; methods; months; mr imaging; mri; mri findings; neck; neonatal; new; noise; non; obstruction; pathology; patients; pediatric; population; post; posterior; potential; prenatal; present; presentation; protocol; pulmonary; purpose; quality; radiation; radiographs; radiologists; radiology; range; renal; resolution; resonance imaging; results; review; right; role; scan; size; spectrum; spinal; spine; spr; studies; study; surgery; syndrome; system; technique; time; tissue; treatment; tumor; ultrasound; university; use; value; vascular; venous; years cache: cord-014687-0am4l5ms.txt plain text: cord-014687-0am4l5ms.txt item: #285 of 2876 id: cord-014712-5u4e00q6 author: None title: Selected Abstracts from the 100th J Project Meeting, Antalya, Turkey, March 12-14, 2014 date: 2014-08-02 words: 36956 flesch: 46 summary: Recurrent severe complicated infections developed in 90% of PID patients. Register for PID patients has been set up in Bulgaria that allowed the collection of data on the incidence and prevalence of PID and the negative effect of these conditions on the population. keywords: age; analysis; antibody; autoimmune; bcg; blood; case; cells; cgd; children; chronic; clinical; cvid; cvid patients; deficiency; diagnosis; disease; disorders; examination; family; findings; gene; group; high; history; hospital; igg; igm; immune; immunodeficiency; immunoglobulin; infections; ivig; laboratory; levels; low; medical; months; mutation; normal; patients; pid; pid patients; present; primary; rate; recurrent; results; scid; skin; study; symptoms; syndrome; therapy; treatment; university; years cache: cord-014712-5u4e00q6.txt plain text: cord-014712-5u4e00q6.txt item: #286 of 2876 id: cord-014794-yppi30a0 author: None title: 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date: 2003-07-31 words: 158305 flesch: 41 summary: The comparison in paired tumor and normal tissue samples showed that phosphorylated ERK-1/ERK-2 expression was higher in tumor cells as compared to surrounding normal salivary parenchyma. IRF-1 derepression by invading tumor cells was associated with poor prognosis. keywords: actin; activity; adenocarcinoma; aim; alpha; analysis; antibodies; antibody; antigen; apoptosis; apoptotic; areas; associated; association; bcl-2; benign; biopsies; biopsy; bladder; blood; bone; breast; breast cancer; breast carcinoma; cancer; cancer cells; cancer patients; carcinoma; cases; cases introduction; cd10; cell carcinoma; cell lymphoma; cell proliferation; cells; changes; chronic; classification; clinical; colorectal; conclusion; control; correlation; cyclin; data; department; detection; development; diagnosis; differences; differentiation; diffuse; disease; dna; electron; epithelial; evaluation; examination; expression; factor; features; female; fibrosis; findings; follow; gastric; gene expression; genes; gland; grade; group; growth; hospital; hpv; human; immunohistochemistry; immunoreactivity; index; infection; inflammatory; introduction; invasion; involvement; ki-67; kit; left; lesions; levels; like; liver; lung; lymph; lymphocytes; lymphoma; malignant; markers; mass; material; mean; metastases; metastatic; methods; microscopy; monoclonal; months; mucosa; muscle; negative; neoplasms; node; non; normal; nuclear; nuclei; number; ovarian; overexpression; p53; p53 expression; papillary; paraffin; parameters; pathology; patients; pattern; pcr; positive; positivity; presence; present; primary; prognostic; progression; proliferation; prostate; protein expression; proteins; receptor; renal; report; results; right; risk; role; samples; sections; series; significance; size; skin; smooth; specific; specimens; stage; staining; status; stromal; studies; study; surgery; survival; system; thyroid; time; tissue; total; treatment; tumor cells; tumors; tumour; type; university; value; vascular; vegf; vessels; women; years cache: cord-014794-yppi30a0.txt plain text: cord-014794-yppi30a0.txt item: #287 of 2876 id: cord-014833-ax09x6gk author: Wu, Jia title: Data Decision and Transmission Based on Mobile Data Health Records on Sensor Devices in Wireless Networks date: 2016-06-20 words: 4031 flesch: 58 summary: This item contains history data, collection data, and doctor data. This type of probability is expressed as follows: PðDiseÞ is the probability of a disease, p his is the probability of history data, a shows the rate of history data, p col is the probability of collection data, b is the rate of collection data, p doc is the probability of doctor data, and c is the rate of doctor data. keywords: data; devices; disease; health; mobile; patients; probability; sensor; wireless cache: cord-014833-ax09x6gk.txt plain text: cord-014833-ax09x6gk.txt item: #288 of 2876 id: cord-014933-3jezc081 author: Özdemir, Seray Karagöz title: Investigation of seasonal frequency and pathogens in febrile neutropenia date: 2019-01-15 words: 1808 flesch: 46 summary: Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America Management of fever in patients with cancer and treatment-induced neutropenia Significance of hospital acquisition of potential pathogens Retrospective analysis of 410 episodes guidelines for the use of antimicrobial agents in neutropenic patients with cancer Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States Invasive grampositive bacterial infection in cancer patients Treatment of febrile neutropenia: what is new? Perspectives for the management of febrile neutropenic patients with cancer in the 21st century Riskfactorsforfebrileneutropenia among patients with cancer receiving chemotherapy: A systematic review Antimicrobial prophylaxis and outpatient management of fever and neutropeniain adults treatedfor malignancy: American Society of Clinical Oncology clinical practice guideline Prophylaxis with fluoroquinolones for bacterial infections in neutropenic patients: a meta-analysis The common cold. To the best of our knowledge, seasons or months have not been defined as risk factors for FEN in hematological cancer patients. keywords: fnes; patients; seasons; study cache: cord-014933-3jezc081.txt plain text: cord-014933-3jezc081.txt item: #289 of 2876 id: cord-014965-efmozngq author: None title: Infectious diseases other than CMV (1st Section) date: 2001-06-11 words: 8012 flesch: 47 summary: First signs of LPD appeared 64, 64 and 67 days after last dose of ATG (16mg/kg) in transplant patients, 30 days after last dose of ATG (30mg/kg) in patient treated with ATG+CsA for relapsing SAA. In transplant patients, cure rate was 41 % and an overall mortality was 58 %. keywords: cell; days; dose; fungal; infection; median; patients; pcr; positive; prophylaxis; pts; results; therapy; treatment cache: cord-014965-efmozngq.txt plain text: cord-014965-efmozngq.txt item: #290 of 2876 id: cord-014976-546zaoxn author: None title: Publication only date: 2006-03-08 words: 51973 flesch: 49 summary: On admission before transplantation patient was presented with massive lymphadenopathy, anemia (Hb 76 g/L), WBC 24.8 x 109/L with absolute lymphocytosis (lymphocytes 98%) and thrombocytopenia 23 x 109/L. Pre-transplant conditioning consisted of high-dose cyclophosphamide and total body irradiation. There are publications about hyperkalemia in patients after renal transplantation but only few reports devote this phenomen in bone marrow transplantation patients. keywords: acute; age; allogeneic; aml; analysis; asct; autologous; blood; blood stem; bone; bone marrow; case; cd34; cell dose; cell transplantation; cells; chemotherapy; children; chimerism; chronic; clinical; complete; conclusion; conditioning; count; csf; cyclophosphamide; day; days; diagnosis; disease; donor; dose; engraftment; follow; grade; graft; group; gvhd; high; hla; host; hsct; levels; lymphoma; marrow; marrow transplantation; median; methods; months; non; number; patients; pbsc; post; prophylaxis; pts; range; recovery; regimen; relapse; remission; results; risk; sct; second; severe; skin; stem cell; study; therapy; time; total; transplanted; treatment; years cache: cord-014976-546zaoxn.txt plain text: cord-014976-546zaoxn.txt item: #291 of 2876 id: cord-014980-cz1gx9oj author: Cheng, Qinglin title: Nomogram for the Individualized Prediction of Survival Among Patients with H7N9 Infection date: 2020-03-20 words: 6152 flesch: 40 summary: The objective of this study is to create a practical instrument for use in predicting an individualized survival probability of H7N9 patients. The objective of this study is to determine predictors for survival for H7N9 patients and create a practical instrument based on results obtained from a multivariable Cox proportional hazard model for use in predicting and evaluating the individualized survival probability in H7N9 patients. keywords: cases; data; h7n9; h7n9 patients; h7n9 vi; infection; influenza; nomogram; patients; probability; study; survival cache: cord-014980-cz1gx9oj.txt plain text: cord-014980-cz1gx9oj.txt item: #292 of 2876 id: cord-014987-nycbjqn6 author: None title: OP 0364-0412 date: 2006-08-24 words: 9808 flesch: 52 summary: Patients with Septic Shock also had a significantly lower oxygen consumption rate when compared to healthy volunteers or patients with SIRS (p<0.001 and p=0.002 respectively. Patients with adequate therapy were older than patients with initial inadequate antibiotic therapy (41.4±21.1 vs 60.5±16.6; p<0.01) but the APACHE II at admission was the same in both groups (21 vs 18'4; p=ns). keywords: admission; care; data; group; hospital; hours; icu; intensive; mean; medical; mortality; outcome; patients; sepsis; study; therapy; vap; ventilation cache: cord-014987-nycbjqn6.txt plain text: cord-014987-nycbjqn6.txt item: #293 of 2876 id: cord-014996-p6q0f37c author: None title: Posters_Monday_12 October 2009 date: 2009-08-06 words: 85276 flesch: 51 summary: ICU patients with acute respiratory failure requiring NIV were studied during three randomized consecutive 20 min-periods of NIV: ICU ventilator with and without NIV mode and NIV ventilator. EFL was recorded in 65% of ICU patients with pulmonary diseases: 65 % of ARDS patients, 75% of patients with respiratory infection, 75% of asthmatics and 85% of patients with COPD. keywords: acute; admission; adult patients; age; aim; analysis; apache; arterial; blood; cardiac; care; care patients; conclusion; control; data; days; diagnosis; differences; duration; early; failure; fluid; group; high; hospital; hospital mortality; icu; icu admission; icu mortality; icu patients; icu stay; incidence; infection; injury; intensive; introduction; lactate; length; levels; low; lung; mean; median; medical; methods; min; model; mortality; n =; non; number; objectives; organ; outcome; oxygen; p =; parameters; patients; pct; period; pneumonia; pressure; pulmonary; rate; renal; respiratory; results; risk; score; sepsis; septic; serum; shock; shock patients; stay; study; surgery; system; test; therapy; time; total; trauma patients; treatment; unit; use; vap; ventilation; volume; years cache: cord-014996-p6q0f37c.txt plain text: cord-014996-p6q0f37c.txt item: #294 of 2876 id: cord-015021-pol2qm74 author: None title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162543 flesch: 45 summary: Ever since we know the role of endotoxins in the pathophysiology of sepsis, antibodies against the S-and R-LPS have also been detected in sepsis patients. In sepsis patients, the CD]4+/CD16+ cells can become a major population with more than 50% of all monocytes in 3 of 18 patients and with more than 500 cells/mm 3 in 4 of 18 cases. keywords: acid; activation; activity; acute; addition; adhesion; administration; aim; analysis; animals; anti; antibodies; antibody; ards; arterial; bacteria; binding; blood; blood cells; blood levels; blood samples; body; burn; capacity; cardiac; cause; cd14; cells; cellular; challenge; changes; circulating; clinical; clp; complement; complications; concentrations; conclusion; conditions; contrast; control; control group; control patients; correlation; course; csf; cultured; cytokine levels; cytokine production; cytokines; damage; data; days; death; decrease; development; differences; disease; dose; dysfunction; effect; elevated; elisa; endothelial; endotoxin; endotoxin levels; evidence; experimental; expression; factor; failure; flow; following; formation; function; gene; gram; group; growth; gut; hepatic; high; host; hours; hrs; human; il-1; il-6; il-6 levels; il-8; ill; immune; increased; induction; infection; inflammation; inflammatory; infusion; inhibitor; injury; ischemia; leukocytes; levels; lipid; liver; lps; lung; lymphocytes; macrophages; mean; mechanisms; mediators; membrane; methods; mice; model; mof; molecules; monoclonal; monocytes; mortality; multiple; necrosis; negative; neutrophils; new; non; normal; number; operation; organ; organ failure; organ injury; outcome; oxygen; p<0.05; parameters; patients; period; peritoneal; phase; placebo; plasma; plasma levels; plasma tnf; play; pmn; positive; post; postoperative; potential; presence; present; pressure; process; production; protein; pulmonary; rate; rats; receptor; reduced; related; release; reperfusion; response; results; risk; role; saline; samples; score; sepsis; sepsis patients; septic; serum; serum levels; severity; sham; shock; sirs; soluble; specific; state; stimulation; studies; study; surface; surgery; survival; syndrome; synthesis; system; systemic; t cells; test; therapeutic; therapy; time; tissue; tnf; tnf levels; tnf production; tnf release; total; trauma patients; treated; treatment; tumor; type; use; values; vascular; vitro; vivo; wound cache: cord-015021-pol2qm74.txt plain text: cord-015021-pol2qm74.txt item: #295 of 2876 id: cord-015024-2xzc0uc5 author: None title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84465 flesch: 50 summary: The primary end point of this study was to evaluate the RVD of the IVC in ICU patients with spontaneous breathing. ICU patient with spontaneous breathing and signs of hypoperfusion (oliguria, mottles, serum lactate level [2 mmol/l) were eligible after the approval of the local Ethics Committee. keywords: acute; administration; admission; age; aim; analysis; apache; baseline; blood; cardiac; care; care patients; care unit; changes; clinical; conclusions; control; critical; data; day; days; death; difference; discharge; dose; effect; factors; failure; fluid; following; function; group; hemodynamic; high; hospital; icu admission; icu patients; incidence; increase; infusion; injury; intensive; introduction; levels; low; lung; management; mean; median; medical; methods; min; months; mortality; n =; non; number; nurses; objectives; outcome; p =; parameters; patients; period; plasma; post; pressure; pulmonary; rate; response; results; resuscitation; risk; score; sepsis; septic; serum; shock; shock patients; stay; study; support; surgery; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; years cache: cord-015024-2xzc0uc5.txt plain text: cord-015024-2xzc0uc5.txt item: #296 of 2876 id: cord-015082-l629n8is author: None title: Poster Sessions 323-461 date: 2002-08-29 words: 26609 flesch: 50 summary: Isoflurane sedation of ICU patients has previously been shown to be useful but has not come into wide clinical use for a number of reasons. Isoflurane administered via the ACD for sedation of ICU patients is environmentally safe, requires small volumes of isoflurane and may provide better quality of sedation than midazolam. keywords: acute; admission; age; analysis; blood; cardiac; care; complications; control; data; days; effect; group; hospital; hours; icu; increase; injury; levels; mean; methods; min; mortality; outcome; patients; postoperative; pressure; protein; rate; rats; response; results; score; sepsis; septic; shock; stay; study; surgery; test; time; trauma; treatment; years cache: cord-015082-l629n8is.txt plain text: cord-015082-l629n8is.txt item: #297 of 2876 id: cord-015090-n6f4xupw author: None title: PS 339-563 date: 2005-09-10 words: 26303 flesch: 51 summary: Propofol is often used as a sedative in ICU patients. The aim of this study was to suggest how the computation of ÄSID should be sophisticated in order to obtain a good correspondence with BE in ICU patients. keywords: admission; age; aim; analysis; blood; brain; cardiac; care; cases; changes; conclusion; costs; data; days; group; hospital; hours; icu; intensive; levels; mean; medical; methods; mortality; non; organ; outcome; patients; period; pressure; rate; risk; score; sepsis; shock; stay; study; surgery; test; time; trauma; tube; unit; university; use; ventilation cache: cord-015090-n6f4xupw.txt plain text: cord-015090-n6f4xupw.txt item: #298 of 2876 id: cord-015126-cyhcbk1j author: None title: PS 0036-0344 date: 2007-08-25 words: 59258 flesch: 52 summary: The aim of this clinical trial is to study CIP in ICU patients (pts) after surgical procedures. The physiological condition of ICU patients is marked by rapidly evolving and frequently life-threatening derangements as well as 'silent' yet important alterations in homeostasis. keywords: acute; admission; age; aim; analysis; apache; arterial; baseline; blood; care; cases; changes; conclusion; control; data; days; disease; early; effects; end; factors; failure; fio2; flow; fluid; glucose; group; high; hospital; hours; icu; icu patients; increase; index; infection; infusion; injury; intensive; level; lung; mean; median; medical; min; model; mortality; non; outcome; parameters; patients; period; pressure; pts; rate; respiratory; results; risk; score; sepsis; septic; shock; shock patients; stay; study; support; surgery; system; test; therapy; time; total; trauma; treatment; unit; use; values; ventilation; volume; years cache: cord-015126-cyhcbk1j.txt plain text: cord-015126-cyhcbk1j.txt item: #299 of 2876 id: cord-015162-6be21d59 author: None title: Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date: 2016-05-04 words: 6848 flesch: 46 summary: Methode: Mit Hilfe strukturierter Fragebögen und Experteninterviews wurde zunächst eine Bedarfsanalyse in Bezug auf Prozesse, Rollen und Dienste in der Notfallversorgung der INA durchgeführt. Nach 5 Tagen unter ultraprotektiver Beatmung und klinischer Erholung mit fortgesetzter Doxycyclin-und Meropenem-Applikation konnte der Patient von der vvECMO geweant und einen Tag später extubiert werden. keywords: accumulation; als; angpt-2; auf; bei; berlin; bleeding; citrate; das; den; der; des; die; ecmo; eine; endothelial; ergebnisse; für; gedvi; ist; lactate; mit; mortality; nach; nicht; objective; ohne; patienten; patients; results; sich; therapie; tie2; und; von; wurden; zur; zusammenfassung cache: cord-015162-6be21d59.txt plain text: cord-015162-6be21d59.txt item: #300 of 2876 id: cord-015306-us58wwmp author: None title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 words: 71292 flesch: 48 summary: The purpose of this study was to determine the diagnostic performance of the application of questionnaires to detect ADHD and other psychiatric disorders in children with functional voiding disorders in general pediatrics consultations Methods: The study was conducted on 32 children between 6 and 13 years of age (20 males) diagnosed with FVD (patient group) and 32 children of the same age (21 males) who had no urinary symptoms (control group). Conclusion: Converting from a CNI based immunosuppressant protocol for Paediatric renal transplantation patients to a Sirolimus based one was effective and the benefit was shown up to 54 months post-transplantation One patient received a desensitisation regime with Rituximab and plasmaexhange pre-transplant and IV immunoglobulin post-operatively. keywords: abstract; acute; age; aki; analysis; biopsy; bladder; blood; cases; cells; children; chronic; ckd; conclusion; control group; correlation; creatinine; data; days; dialysis; difference; disease; dose; ebv; effect; enuresis; expression; factors; failure; findings; follow; function; gene; glomerular; grade; graft; group; group b; growth; hospital; hsp; igan; infection; injury; kidney; kidney disease; kidney injury; levels; mean; median; medical; methods; model; months; mutations; nephrology; nephropathy; nocturnal; non; objective; patients; pediatric; period; post; primary; proteinuria; range; rate; rats; recipients; renal; results; risk; role; serum; stage; study; study group; survival; syndrome; term; therapy; time; total; transplantation; treatment; treatment group; tubular; university; urinary; urine; vur; weeks; weight; years cache: cord-015306-us58wwmp.txt plain text: cord-015306-us58wwmp.txt item: #301 of 2876 id: cord-015324-y44sfr0c author: None title: Scientific Programme date: 2007-09-01 words: 197844 flesch: 49 summary: In the group I, consisted of 63 infants (35 males and 28 females) PCD increased during the time in 3,2% infants, remained unchanged in 11,1%, decreased in 14,3%, and disappeared in 71,4% patients. There was no significant difference between renal transplant patients and healthy controls in genotype distribution of allelic frequencies of IL-6, FAS and MCP-1 polymorphisms. keywords: abnormalities; according; acid; activity; acute; adult patients; adults; age; aim; analysis; anti; associated; background; baseline; biopsy; blood; body; bone; boys; calcium; cases; cause; cells; changes; childhood; children; chronic; ckd; clinical; complete; conclusion; control; control group; correlation; course; creatinine; crf patients; csa; damage; data; day; days; development; diagnosis; dialysis; dialysis patients; difference; disease; dose; duration; dysfunction; effect; elevated; end; esrd; examination; excretion; expression; factor; failure; family; findings; follow; fsgs; function; gene; gfr; girls; glomerular; glomerulonephritis; grade; graft; group; growth; hd patients; hematuria; history; hospital; human; hus; hypertension; iga; incidence; increase; infants; infection; initial; injury; kidney; kidney disease; levels; male; mean; median; mesangial; metabolic; methods; mice; min/1.73; mmf; months; mrna; mutations; negative; nephritis; nephrology; nephropathy; nephrotic; non; normal; number; objective; onset; outcome; p<0.001; p<0.05; parameters; patients; pcr; pediatric; period; peritoneal; plasma; population; positive; post; prednisone; presence; present; pressure; primary; progression; proteinuria; pth; range; rare; rate; ratio; rats; reflux; rejection; relapse; remission; renal; renal biopsy; renal transplantation; report; response; results; risk; role; second; serum; severe; specific; srns; stage; steroid; studies; study; study group; survival; symptoms; syndrome; system; tacrolimus; term; test; therapy; time; total; tract; transplant patients; transplantation; treated; treatment; tubular; type; ultrasound; urinary; urine; uti; values; vs.; vur; vur patients; weeks; weight; years; yrs cache: cord-015324-y44sfr0c.txt plain text: cord-015324-y44sfr0c.txt item: #302 of 2876 id: cord-015334-8p124rwp author: None title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 words: 51170 flesch: 47 summary: The main off-label indications were prevention of hemorrhagic risk of antiplatelet agent (23%), hemoglobin decrease(16%), anticoagulant co-prescription(13%), steroids co-prescription(6%). A rinse volume of 10 ml improved significantly the transit of Mopral Ò , Ogast Ò and Ogastoro Ò (+4.8%, keywords: administration; age; analysis; background; blood; care; cases; community; conclusions; control; criteria; data; days; department; design; disease; dosage; dose; drug; effects; errors; group; guidelines; health; hospital; information; interventions; level; management; mean; measures; medical; medication; months; new; non; number; nurses; objective; oral; order; outcome; outcome measures; pain; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; practice; prescriptions; problems; quality; questionnaire; recommendations; results; risk; safety; setting; studies; study; therapy; time; total; treatment; use; years cache: cord-015334-8p124rwp.txt plain text: cord-015334-8p124rwp.txt item: #303 of 2876 id: cord-015335-l0kjxhd1 author: None title: Irish Society of Gastroenterology: Proceedings for summer meeting – 26th/27th May 1995 in Galway date: 1995 words: 8736 flesch: 49 summary: It is postulated that cells may be of the Th2 phenotype in normal subjects and coeliac patients with inactive disease (due to the observed increase in IL6 in the absence of IFN~t production) The differences between the IBS group (42.8 + 5.6 yr) and the controls or the CD and UC patients were not statistically significant. keywords: age; cell; coeliac; controls; disease; group; liver; mean; non; normal; patients; range; secretion; study; subjects; treatment; tumour cache: cord-015335-l0kjxhd1.txt plain text: cord-015335-l0kjxhd1.txt item: #304 of 2876 id: cord-015348-qt0worsl author: None title: Abstract date: 2010-07-30 words: 74228 flesch: 40 summary: The role of autophagy in cancer seems to be dual: On one hand, there is a growing body of evidence supporting the idea that autophagy may represent a tumor suppressor mechanism by reducing intratumoral necrosis, restricting oxidative stress and limiting chromosomal instability; on the other hand, autophagy may be an important process used by tumor cells to escape various types of stress and even therapeutic agents. At a higher magnification, tumor cells are grouped in small nests formed by large cells, with an abundant, pale, mucus-laden cytoplasm and an eccentric nucleus. keywords: adenocarcinoma; age; aim; analysis; antibodies; antibody; benign; biopsies; biopsy; brain; breast; breast cancer; cancer; carcinoma; cases; cells; changes; chronic; clinical; colorectal; conclusion; control; correlation; cystic; data; dept; development; diagnosis; disease; egfr; epithelial; evaluated; evaluation; examination; expression; factors; features; findings; gastrointestinal; gene; grade; group; growth; high; hyperplasia; ihc; immunohistochemistry; inflammatory; information; kit; lesions; like; lung; lymph; lymphoma; malignant; markers; mass; melanoma; metastatic; method; microscopy; molecular; mutations; new; node; non; nuclear; number; objective; p53; parameters; pathologists; pathology; patients; presence; present; primary; prognostic; proliferation; protein; report; results; risk; role; samples; slides; specimens; stage; staining; stromal; studies; study; system; therapy; time; tissue; treatment; tumor; tumor cells; tumours; type; use; vascular; vegf; years cache: cord-015348-qt0worsl.txt plain text: cord-015348-qt0worsl.txt item: #305 of 2876 id: cord-015352-2d02eq3y author: None title: ESPR 2017 date: 2017-04-26 words: 82384 flesch: 43 summary: In 2011, the image gently campaign released a safety checklist for performing digital radiography examinations on pediatric patients which is easily applicable to every radiology service. Health care professionals have a shared responsibility for communicating risks and benefits of imaging procedures to patients, especially in the case of pediatric patients. keywords: accuracy; acute; adc; age; agreement; analysis; anomalies; approach; assessment; biopsy; body; bone; bowel; brain; cases; changes; chest; children; contrast; correlation; cxr; data; diagnosis; diffusion; disease; dose; dwi; edema; evaluation; examination; findings; fluid; follow; group; head; hepatic; high; images; imaging; imaging findings; infection; information; injury; involvement; jia; left; lesions; literature; liver; lung; mass; mean; months; mr imaging; mre; mri; non; normal; objective; patients; pediatric; pneumonia; points; population; positive; possible; post; potential; presence; present; presentation; procedure; pulmonary; radiation; radiologists; radiology; range; renal; results; right; risk; role; sensitivity; sequences; signal; standard; studies; study; symptoms; syndrome; system; technique; time; tissue; total; trauma; treatment; tumor; ultrasound; use; values; vascular; volume; wall; years cache: cord-015352-2d02eq3y.txt plain text: cord-015352-2d02eq3y.txt item: #306 of 2876 id: cord-015354-yknwveyz author: None title: Abstracts_Poster presentations date: 2007-09-18 words: 221717 flesch: 51 summary: Results: The AS-IS diagram identified the following pre-scan steps as candidates for a change: i) non-appearance of patients, ii) measurement of body weight and height, calculation of body mass index and sestamibi dose, iii) preparations and check of patient dose, iv) positioning of intravenous cannula and dose injection, v) check of medication and withdrawal of relevant drugs before stress acquisition, and vi) entering of informations into a working sheet and the patient protocol. Patients data were analysed using both Kaplan-Meier event-free survival curves and Cox multivariate analyses. keywords: 18f; 99mtc; accumulation; accuracy; acquisition; activity; administration; aim; analysis; area; artery; assessment; attenuation; average; background; blood; body; bone; bone scintigraphy; brain; brain spect; breast; cad; camera; cancer patients; carcinoma; carcinoma patients; cardiac; cases; cell; changes; chemotherapy; clinical; collimator; comparison; conclusion; contrast; control; coronary; correlation; ct data; ct findings; ct images; ct imaging; ct results; ct scan; ct studies; ct study; data; day; days; decrease; detection; determine; diagnosis; difference; disease; dm patients; dose; dose ct; effect; energy; evaluate; evaluation; examination; factors; fdg pet; fdg uptake; findings; follow; function; gamma; group; group patients; heart; high; hospital; hours; i-131; images; imaging; increased; information; injection; kidney; left; lesions; level; liver; low; lung; lymph; m tc; malignant; management; material; mbq; mci; mean; medical; medicine; metastases; methods; mibi; min; minutes; model; months; mps; mri; myocardial; negative; node; non; normal; nuclear; number; order; pain; parameters; patients; patients scintigraphy; pd patients; perfusion; perfusion scintigraphy; perfusion spect; perfusion study; period; pet; pet ct; pet imaging; pet scan; phantom; phase; planar; positive; post; presence; present; primary; procedure; pts; pulmonary; purpose; quality; radiation; radioiodine; range; rate; ratio; reconstruction; recurrence; region; regional; renal; resolution; respectively; response; rest; results; right; risk patients; scan; scintigraphy; second; sensitivity; sentinel; serum; size; sln; software; specific; specificity; spect; spect data; spect images; spect study; stage; standard; stress; studies; study; study results; subjects; surgery; suv; symptoms; system; technique; test; therapeutic; therapy; thyroid; thyroid cancer; time; tissue; total; tracer; treatment; tumor; type; underwent; university; uptake; use; value; volume; women; years cache: cord-015354-yknwveyz.txt plain text: cord-015354-yknwveyz.txt item: #307 of 2876 id: cord-015359-gf32a6f1 author: None title: B scientific sessions (SS) date: 2002 words: 159804 flesch: 47 summary: The PTB accelerates the diagnostic management of ER-and ICU-patients and hence increases CT patient throughput. Non-surgical patients had radiological follow up for minimum 1 year Conclusion: The incidence of malignancy in Bosniak category III is 60.7 % (95 % confidence interval). keywords: abnormalities; accuracy; acquisition; acute; administration; aim; analysis; angiography; aortic; area; arterial; arteries; artery; assessment; axial; biopsy; bladder; blood; bone; bowel; brain; breast; cancer; carcinoma; cardiac; carotid; cases; changes; children; clinical; comparison; complications; conclusion; contrast; contrast enhancement; control; conventional; coronal; coronary; correlation; ct data; ct findings; ct images; ct imaging; ct scans; data; days; detection; detector; diagnosis; diameter; difference; digital; disease; doppler; dose; dsa; dynamic; enhancement; evaluation; examination; field; findings; flow; follow; fractures; function; good; grade; group; hepatic; images; imaging; increase; information; injection; intensity; left; lesions; level; liver; lung; lymph; materials; mean; measurements; metastases; methods; minutes; months; mr images; mr imaging; mra; mri; mri findings; msct; multislice ct; myocardial; n =; new; nodes; non; number; p =; pain; parameters; patients; patients ct; patients mri; perfusion; phase; positive; post; presence; present; procedure; protocol; pulmonary; purpose; quality; r =; radiation; radiologists; range; rate; reconstruction; reduction; renal; resolution; results; scans; score; sensitivity; sequences; siemens; signal; significant; size; slice; specificity; spine; spiral ct; standard; stenosis; stent; studies; study; subjects; surgery; system; t =; technique; therapy; thickness; time; tissue; tool; total; treatment; tumor; tumours; type; ultrasound; underwent; use; values; vascular; venous; volume; wall; weighted; years cache: cord-015359-gf32a6f1.txt plain text: cord-015359-gf32a6f1.txt item: #308 of 2876 id: cord-015365-iqdi99pd author: None title: 25th Annual Meeting of the Austrian Society of Transplantation, Transfusion and Genetics Graz, October 19–21, 2011 date: 2011 words: 30745 flesch: 44 summary: Die Reduktion der Sporenlast in der Umgebung von Ziel dieser Studie war es, die Rate von okkulten Karzinomen in unserem Kollektiv an äthyltoxischer Zirrhose erkrankter und für diese Indikation transplantierter Patienten der letzten 10 Jahre zu erheben und den Einfluss auf das rezidivfreie uund Gesamtüberleben nach Lebertransplantation zu untersuchen. Methodik. keywords: acute; age; allograft; als; analysis; anti; atg; auf; background; bei; belatacept; blood; bone; cardiac; cell transplantation; cells; chimerism; chronic; complications; conclusions; das; data; days; der; des; die; disease; donor; early; eine; expression; failure; follow; function; für; graft; group; heart; human; immune; induction; infection; ist; kidney; levels; liver; lung; marrow; mean; median; methods; mice; mit; model; months; mspcs; n ¼; nach; nicht; oder; organ; p ¼; patienten; patients; post; range; rate; recipients; rejection; renal; results; serum; sich; stem; study; survival; t cells; tacrolimus; therapie; therapy; time; tissue; tolerance; transplantation; treatment; und; vivo; von; vor; werden; wurde; years cache: cord-015365-iqdi99pd.txt plain text: cord-015365-iqdi99pd.txt item: #309 of 2876 id: cord-015368-a0qz4tb9 author: None title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 words: 86712 flesch: 48 summary: In an unselected cohort of surgical patients those presenting with infection prior to surgery and those undergoing abdominal surgery are at highest risk of death from infection. After resection patients should have long term follow up. keywords: acute; age; aim; analysis; aortic; approach; artery; average; background; blood; breast; bypass; cancer; cancer patients; carcinoma; cardiac; cases; cell; chemotherapy; children; colon; colorectal; complications; conclusions; control; data; days; department; der; diagnosis; die; disease; endoscopic; esophageal; experience; expression; female; findings; follow; following; function; gastric; grade; graft; group; heart; hernia; high; hospital; iii; incidence; increase; infection; injuries; laparoscopic; left; lesions; levels; liver; male; management; mean; median; medical; methods; min; months; morbidity; mortality; n ¼; nerve; non; number; operation; outcome; p ¼; pain; patients; period; postoperative; preoperative; present; procedure; quality; range; rate; repair; resection; results; right; risk; skin; stage; standard; stay; study; surgery; surgical; survival; symptoms; system; technique; term; therapy; time; tissue; total; trauma; treatment; tumor; type; valve; vs.; weight; years cache: cord-015368-a0qz4tb9.txt plain text: cord-015368-a0qz4tb9.txt item: #310 of 2876 id: cord-015369-72cjogxz author: None title: 50th Annual Meeting of the Austrian Society of Surgery. Vienna, June 18–20, 2009. Guest Editors: Albert Tuchmann, Erhard Schwanzer, Benedikt Walzel date: 2009 words: 71211 flesch: 45 summary: eröffneten Aortenbogen in die Aorta deszendens vorgeschoben, anschließend wird mit der Dacron Hälfte der Prothese der Aortenbogen und die distale Aorta aszendens ersetzt. Das postoperative Kontroll-und Stimulationsschema beträgt 9 Monate, in denen die Aussprossung der Axone in monatlichen Abständen evaluiert wird. keywords: abteilung; acute; age; aim; allen; als; analyse; analysis; anastomosis; aorta; aortic; approach; artery; auch; auf; auf eine; aufgrund; aus; background; behandlung; bei der; bei einer; beiden; beim; betrug; biopsy; bis; blood; bmi; body; breast; bypass; cancer; cancer patients; carcinoma; cardiac; cases; cells; chemotherapy; children; chirurgische; cle; clinical; closure; colon; complications; conclusions; control; das; dass; data; days; death; dem; department; der; der behandlung; der gruppe; der operation; des; diagnosis; die; dieser; disease; donor; durch; durchgeführt; effect; eine; endoscopic; erfolgte; ergebnisse; es zu; esophageal; esophagus; experience; expression; failure; fall; female; findings; fistula; fixation; follow; formation; function; fällen; für; für die; gastric; gerd patients; graft; group; grundlagen; gruppe; hand; healing; heart; hernia; hospital; iii; incidence; infection; invasive; ist; ist der; ist die; ist eine; jahren; jedoch; kam; kann; kein; komplikationen; konnte; können; laparoscopic; left; length; levels; life; liver; loss; management; mean; median; mesh; metastases; methodik; methods; min; mit; mit der; mit einer; mittels; model; monaten; months; morbidity; mortality; n ¼; nach; nach der; new; nicht; node; non; number; nur; oder; ohne; open; operation; outcome; p ¼; pain; patienten; patienten mit; patients; period; perioperative; pgd; placement; porcine; positive; postoperative; present; primary; procedure; protein; pulmonary; quality; rahmen; rahmen der; range; rate; recurrence; reflux; removal; repair; report; resection; response; results; right; risk; schlussfolgerungen; score; serum; sich; sich der; sich die; sind; skin; sowie; stage; standard; stay; stent; studie; study; surgery; survival; symptoms; system; technik; technique; term; therapie; therapie der; therapy; thoracic; time; tissue; total; transplantation; treatment; tumor; type; und; und bei; und der; und die; und eine; und mit; unserer; unter; use; v.a.c; valve; von; von der; vor; vs.; wall; war; waren; weeks; wegen; weight; werden; werden die; werden und; wird; wound; wurde; wurde der; wurde eine; während; years; zeigte; zu einer; zum; zur; zwischen; über cache: cord-015369-72cjogxz.txt plain text: cord-015369-72cjogxz.txt item: #311 of 2876 id: cord-015370-4jfgsic7 author: None title: 55th Annual Meeting of the Austrian Society of Surgery: Graz, June 25—27, 2014 date: 2014-06-03 words: 46648 flesch: 41 summary: Ergebnisse: In der Gruppe der SIL-AE gab es -vergleichbar mit den Gruppen der multiport und der offenen AE -keine relevanten Unterschiede in der OP Dauer, Mortalität und Morbidität. In der Mehrzahl der Patienten wurde nach Diagnose eine LR-spezifische Therapie durchgeführt (84,8 % CC, 90,65 % RC), häufig mittels einem erneuten chirurgischen Ansatz (82,1 %-CC, 56,3 %-RC). keywords: abteilung; access; acute; age; alle; als; alter; analysis; aortic; approach; artery; auch; auf; aufgrund; aus; background; band; behandlung; bei; bei der; betrug; bis; bleeding; blood; bmi; body; bypass; bzw; cancer; case; cell; center; changes; chirurgie; chirurgischen; complications; concentrations; conclusions; dar; das; dass; data; days; dem; der; der patient; des; die; dieser; disease; durch; durchgeführt; effect; eine; endoscopic; erfolgte; ergebnisse; experience; expression; failure; fall; female; follow; formation; function; fällen; für; gastric; graft; group; grundlagen; gruppe; heart; hernia; hospital; implantation; incision; ist; ist die; ist eine; jahre; jedoch; kann; kidney; komplikationen; konnte; können; laparoscopic; laparoskopische; lebensqualität; left; levels; literatur; liver; loss; management; mean; median; methodik; methods; min; minimal; mit; mit der; mit einer; mittels; months; morbidity; mortality; n =; nach; nicht; oder; ohne; operation; operiert; option; outcome; p =; pain; pancreas; patienten; patienten mit; patients; peg; port; postoperative; pouch; primary; procedure; prosthesis; rahmen; range; rate; removal; repair; report; resection; results; right; risk; rygb; schlussfolgerungen; score; serum; sich; sil; sind; sleeve; sowie; specimen; stage; standard; stellt; stenosis; step; studie; study; surgeons; surgery; survival; system; tapp; tavi; technik; term; therapie; time; tissue; total; transplantation; trauma; treatment; tumor; und; und der; und eine; und mit; unserer; unter; valve; verlauf; versorgung; von; von der; vor; vorgehen; war; waren; wegen; weight; werden; wird; wurde; wurde die; years; zeigte; zum; zur; zwei; zwischen; österreich; über cache: cord-015370-4jfgsic7.txt plain text: cord-015370-4jfgsic7.txt item: #312 of 2876 id: cord-015372-76xvzvdg author: None title: National scientific medical meeting 1996 abstracts date: 1996 words: 36628 flesch: 50 summary: Control patients were enrolled who had no clinical evidence of rheumatological disease, A salivary sample was collected and examined by light microscopy. Drug induced photosensitivity may look identical clinically, have a similar history and patients with CAD may be treated with potentially photosensitising drugs. keywords: acid; activity; age; aim; analysis; antibodies; blood; bone; care; cases; cells; children; controls; data; day; difference; disease; drug; expression; females; findings; following; group; hiv; hospital; incidence; increase; infection; irish; levels; males; mean; months; negative; number; pain; patients; pcr; period; population; positive; present; range; rate; response; results; risk; samples; serum; skin; studies; study; subjects; test; therapy; time; total; treatment; type; use; virus; years cache: cord-015372-76xvzvdg.txt plain text: cord-015372-76xvzvdg.txt item: #313 of 2876 id: cord-015389-vwgai4k9 author: None title: Publication only date: 2009-03-25 words: 23906 flesch: 53 summary: Two years overall survival and disease free survival of AML patients were 70% and 67% respectively. The use of this AMD3100 in combination with G-CSF in patients unable to collect adequate CD34+ cells with G-CSF alone was recently reported in 280 patients with lymphoma and multiple myeloma (MM) . keywords: acute; age; allogeneic; aml; blood; cases; cd34; cell; cell transplantation; conclusion; conditioning; cord; days; disease; donor; dose; engraftment; graft; group; gvhd; hsct; median; methods; months; patients; post; pts; range; regimen; relapse; remission; results; risk; second; stem; stem cell; survival; therapy; time; transplantation; treatment; years cache: cord-015389-vwgai4k9.txt plain text: cord-015389-vwgai4k9.txt item: #314 of 2876 id: cord-015569-vy49r1zd author: None title: Abstracts from the 45(th) Annual Meeting of Japanese Association for the Stusy of Taste and Smell (JASTS 2011), Kanazawa, Japan, October 5-7(th), 2011 (The president of the meeting was Dr. Takaki Miwa, Kanazawa Medical University) date: 2012-05-17 words: 18896 flesch: 49 summary: However, mechanism of recognition of taste receptor cells which express appropriate taste receptor is still unknown. Using calcium imaging and immunocytochemistry, we revealed that ATP activates type II and III taste cells and HCl activates type III taste cells, and also that HCl and ATP activate separate subpopulations of taste cells. keywords: acid; activity; cells; dashi; flavor; food; intake; mice; nerve; odor; olfactory; patients; preference; rats; receptor; responses; results; saliva; sensory; solution; stimulation; stimuli; study; subjects; sucrose; swallowing; system; taste; taste cells; type; umami; water cache: cord-015569-vy49r1zd.txt plain text: cord-015569-vy49r1zd.txt item: #315 of 2876 id: cord-015640-zdwmxaz3 author: Tong, C. Y. W. title: Clinical Virology in NICU, PICU and AICU date: 2011-08-10 words: 6055 flesch: 39 summary: Clinically, influenza infection is characterised by abrupt onset of fever, sore throat, myalgia, cough, headache and malaise. key: cord-015640-zdwmxaz3 authors: Tong, C. Y. W.; Schelenz, S. title: Clinical Virology in NICU, PICU and AICU date: 2011-08-10 journal: Infection Control in the Intensive Care Unit DOI: 10.1007/978-88-470-1601-9_20 sha: doc_id: 15640 cord_uid: zdwmxaz3 Viruses are significant causes of nosocomial infections, particularly in intensive care unit (ICU) where seriously ill and vulnerable patients are being cared for. keywords: care; control; diagnosis; disease; health; icu; infection; influenza; patients; risk; rsv; transmission; virus; workers cache: cord-015640-zdwmxaz3.txt plain text: cord-015640-zdwmxaz3.txt item: #316 of 2876 id: cord-015884-mtpbzgr9 author: Haynes, Alice title: Current Practices for Infection Prevention in the Hospital Settings date: 2013-08-06 words: 3218 flesch: 43 summary: The concept of cohorting, allowing patients with communicable diseases to be housed in the same room as other patients, was fi rst applied in the Providence City Hospital [ 5 ] . This combination of PPE can also impact the safety of other patients that are being cared for by the same healthcare worker and may potentially be exposed to pathogens that can be transported to them on the caregiver's clothing. keywords: agents; disease; infection; isolation; patient; precautions; transmission cache: cord-015884-mtpbzgr9.txt plain text: cord-015884-mtpbzgr9.txt item: #317 of 2876 id: cord-015922-5wwy0m2k author: Marty, Francisco M. title: Infection in the Hematopoietic Stem Cell Transplant Recipient date: 2008 words: 10256 flesch: 30 summary: Hematology / the Education Program of the Invasive aspergillus infection: possible nonward common source within the hospital environment Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors Introduction to marrow and blood stem cell transplantation Infectious complications associated with alemtuzumab use for lymphoproliferative disorders Infliximab use in patients with severe graftversus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning Invasive aspergillosis following hematopoietic cell transplantation: outcomes and prognostic factors associated with mortality Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection: a prospective feasibility study Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas Prophylactic antimicrobial agents and the importance of fitness Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials Escherichia coli resistant to fluoroquinolones in patients with cancer and neutropenia Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. Infectious Diseases Society of America Disseminated trichosporonosis caused by Trichosporon loubieri Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia Breakthrough trichosporonosis in patients with hematologic malignancies receiving micafungin Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus Should the consensus guidelines' specific criteria for the diagnosis of invasive fungal infection be changed? Reactivity of (1->3)-beta-d-glucan assay with commonly used intravenous antimicrobials Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia Empiric antifungal therapy in febrile granulocytopenic patients. keywords: cell; cmv; disease; gvhd; hsct; infection; marrow; patients; post; prophylaxis; recipients; risk; stem; therapy; transplant; transplantation; treatment; use; virus cache: cord-015922-5wwy0m2k.txt plain text: cord-015922-5wwy0m2k.txt item: #318 of 2876 id: cord-015930-18qznqp0 author: Denstaedt, Scott J. title: Hemophagocytic Lymphohistiocytosis and Other Culture Negative Sepsis-Like Syndromes in the ICU date: 2019-07-24 words: 4496 flesch: 31 summary: However, when utilized in a prospective cohort of adult HLH patients, only 40% of patients had an identifiable mutation, highlighting the lack of clear genetic cause in adult HLH. Hemophagocytic syndromes -an update How I treat hemophagocytic lymphohistiocytosis Genetic features of late onset primary hemophagocytic lymphohistiocytosis in adolescence or adulthood Hemophagocytic lymphohistiocytosis: clinical analysis of 103 adult patients Adult haemophagocytic syndrome Coagulation disorders and bleedings in critically ill patients with hemophagocytic lymphohistiocytosis HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Sensitivity and specificity of bone marrow hemophagocytosis in hemophagocytic lymphohistiocytosis Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study Treatment of familial hemophagocytic lymphohistiocytosis with antithymocyte globulins, steroids, and cyclosporin A A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol Critical care management of patients with hemophagocytic lymphohistiocytosis Haemophagocytic lymphohistiocytosis in adults: a multicentre case series over 7 years Lymphoma-associated hemophagocytic syndrome: clinical features and treatment outcome Lymphoma-associated hemophagocytic lymphohistiocytosis: experience in adults from a single institution Reactive hemophagocytic syndrome in adults: a multicenter retrospective analysis of 162 patients Clinical characteristics, prognostic factors, and outcomes of adult patients with hemophagocytic lymphohistiocytosis Clinical characteristics, prognostic factors and outcomes of adult patients with hemophagocytic lymphohistiocytosis Prognostic factors of early death in a cohort of 162 adult haemophagocytic syndrome: impact of triggering disease and early treatment with etoposide Targeted high-throughput sequencing for genetic diagnostics of hemophagocytic lymphohistiocytosis Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis Elevated serum ferritin is not specific for hemophagocytic lymphohistiocytosis Rate of decline of ferritin in patients with hemophagocytic lymphohistiocytosis as a prognostic variable for mortality Hemophagocytic syndrome and critical illness: new insights into diagnosis and management Marked hyperferritinemia does not predict for HLH in the adult population Significance of Hyperferritinemia in hospitalized adults A high sIL-2R/ferritin ratio is a useful marker for the diagnosis of lymphoma-associated hemophagocytic syndrome Diagnostic accuracy of a specific cytokine pattern in hemophagocytic lymphohistiocytosis in children Multicenter study of combination DEP regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis Interleukin 1 receptor antagonist Anakinra, intravenous immunoglobulin, and corticosteroids in the management of critically ill adult patients with hemophagocytic lymphohistiocytosis Salvage therapy of refractory hemophagocytic lymphohistiocytosis with alemtuzumab Macrophage activation syndrome in adults: recent advances in pathophysiology, diagnosis and treatment Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients Adult-onset Still's disease Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a European league against rheumatism/American College of Rheumatology/Paediatric rheumatology international trials organisation Collaborat Development and validation of the HScore, a score for the diagnosis of reactive Hemophagocytic syndrome Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases: analysis of 30 cases American College of Rheumatology Recommendations for the treatment of juvenile idiopathic arthritis recommendations for the medical therapy of children with systemic juvenile idiopathic arthritis and tuberculosis screening among children receiving biologic medications Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis Interleukin-1 receptor blockade is associated with reduced mortality in Sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial * Chimeric antigen receptor T cells for sustained remissions in leukemia Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia Cytokine release syndrome with chimeric antigen receptor T cell therapy Toxicities of chimeric antigen receptor T cells: recognition and management CD19 CAR -T cells of defined CD4 + : CD8 + composition in adult B cell ALL patients Chimeric antigen receptor-modified T cells for acute lymphoid leukemia Current concepts in the diagnosis and management of cytokine release syndrome keywords: adult; diagnosis; hlh; lymphohistiocytosis; patients; sepsis; steroids; syndrome; therapy; treatment cache: cord-015930-18qznqp0.txt plain text: cord-015930-18qznqp0.txt item: #319 of 2876 id: cord-015946-biu5zxd1 author: Peng, Daizhi title: Research Advances in Biomarker for Sepsis date: 2016-11-16 words: 5102 flesch: 32 summary: [71] found that miR-150 levels were significantly reduced in both leukocytes and plasma of sepsis patients and had a negative correlation with the level of disease severity measured by the Sequential Organ Failure Assessment (SOFA) score, which made it a biomarker of early sepsis. [72, 73] investigated the levels of miR-150 and miR-143 in peripheral blood leukocytes in sepsis patients with RT-PCR, and found that the expression levels of miR-150 and miR-143 were significantly decreased in sepsis patients and could reflect the severity of sepsis in certain degree, which not only made it a marker to reflect the situation of inflammatory response, but also made it a prognostic marker in sepsis. keywords: biomarkers; cell; dna; expression; gene; infection; levels; patients; plasma; potential; protein; sepsis; serum cache: cord-015946-biu5zxd1.txt plain text: cord-015946-biu5zxd1.txt item: #320 of 2876 id: cord-016105-jkaxemmb author: Nakao, Mutsuhiro title: Prevention and Psychological Intervention in Depression and Stress-Related Conditions date: 2011 words: 4506 flesch: 35 summary: It has long been acknowledged that patients and physicians tend to have different and sometimes conflicting views on health problems and on reasonable expectations for managing such problems. The reach of the disease-oriented system (DOS), problem-based learning (PBL), and case methods More broadly, we need to adopt procedures that enable the identification and measurement of problems, the analysis of key determinants, the development of intervention strategies, the selection of an optimal intervention strategy, and the evaluation of outcomes to solve public health problems involving depression or other mental illnesses. keywords: communication; depression; education; health; japan; method; patient; problem cache: cord-016105-jkaxemmb.txt plain text: cord-016105-jkaxemmb.txt item: #321 of 2876 id: cord-016110-mlwe7fzz author: Specks, Ulrich title: Pulmonary Manifestations of Vasculitis date: 2014-05-05 words: 7840 flesch: 32 summary: Sensorineural hearing loss and scleritis are clearly severe disease manifestations. key: cord-016110-mlwe7fzz authors: Specks, Ulrich title: Pulmonary Manifestations of Vasculitis date: 2014-05-05 journal: Pulmonary Manifestations of Rheumatic Disease DOI: 10.1007/978-1-4939-0770-0_10 sha: doc_id: 16110 cord_uid: mlwe7fzz Respiratory manifestations in patients with a primary systemic vasculitis syndrome need to be separated into those caused by the vasculitis itself, those related to treatment complications, and those caused by unrelated or only indirectly related comorbidities such as obstructive sleep apnea. keywords: alveolar; ammation; anca; associated; capillaritis; dah; disease; gpa; hemorrhage; infl; mpa; patients; pulmonary; respiratory; therapy; vasculitis cache: cord-016110-mlwe7fzz.txt plain text: cord-016110-mlwe7fzz.txt item: #322 of 2876 id: cord-016127-tbot0fc9 author: Hurtado, F. J. title: Sepsis: Clinical Approach, Evidence-Based at the Bedside date: 2009-11-19 words: 4879 flesch: 42 summary: Since 2002 the Surviving Sepsis Campaign was introduced with the initial goal of increasing clinicians' awareness about severe sepsis mortality and to improve outcome in this patient population. Severe sepsis relates to the presence of sepsis and one or more related organ dysfunctions. keywords: dysfunction; evidence; failure; infection; mortality; organ; patients; resuscitation; sepsis; shock; therapy cache: cord-016127-tbot0fc9.txt plain text: cord-016127-tbot0fc9.txt item: #323 of 2876 id: cord-016135-44pgjah8 author: Sen, Ayan title: Postoperative Management of Composite Tissue Graft Transplantation date: 2016-06-03 words: 2621 flesch: 39 summary: The Center for Disease Control recommends that ventilated patients should ideally be placed in the semi-recumbent position with the head of the bed elevated at an inclination of 30-45°. This chapter discusses the general and specific postoperative management of patients following CTA. keywords: face; graft; immunosuppression; management; patients; rejection; risk; transplant; transplantation cache: cord-016135-44pgjah8.txt plain text: cord-016135-44pgjah8.txt item: #324 of 2876 id: cord-016177-fz48wydz author: Bezek, Sarah title: Emergency Triage of Highly Infectious Diseases and Bioterrorism date: 2020-01-03 words: 4382 flesch: 30 summary: Disease control policies and programs can strengthen infectious disease and bioterrorist attack care and surveillance at each of these levels. An emergency department response to severe acute respiratory syndrome: a prototype response to bioterrorism Outside the box and into thick air: implementation of an exterior mobile pediatric emergency response team for North American H1N1 (swine) influenza virus in Development and use of mobile containment units for the evaluation and treatment of potential Ebola virus disease patients in a United States Hospital The current state of bioterrorist attack surveillance and preparedness in the US Hospital triage system for adult patients using an influenzalike illness scoring system during the 2009 pandemic-Mexico The simple triage scoring system (STSS) successfully predicts mortality and critical care resource utilization in H1N1 pandemic flu: a retrospective analysis Triage care of the critically ill and Injured during pandemics and disasters: CHEST consensus statement Surge capacity of hospitals in emergencies and disasters with a preparedness approach: a systematic review Regional treatment network for Ebola and other special pathogens S. airport entry screening in response to pandemic influenza: modeling and analysis Enhanced Ebola screening to start at five U.S. airports for all people entering U.S. from Ebola-affected countries Responding to communicable diseases in internationally mobile populations at points of entry and along porous borders A systematic review of emerging respiratory viruses at the Hajj and possible coinfection with Streptococcus pneumoniae Natural disasters, armed conflict, and public health The sphere handbook: humanitarian charter and minimum standards in humanitarian response Bioterrorism readiness plan: a template for healthcare facilities Augmentation of hospital critical care capacity after bioterrorist attacks or epidemics: recommendations of the Working Group on Emergency Mass Critical Care AAP Disaster Preparedness Advisory Council. keywords: agents; attack; bioterrorist; care; emergency; health; patients; response; systems; treatment; triage cache: cord-016177-fz48wydz.txt plain text: cord-016177-fz48wydz.txt item: #325 of 2876 id: cord-016208-u12ngkpc author: Andersen, Bjørg Marit title: Intensive Patient Treatment date: 2018-09-25 words: 4582 flesch: 47 summary: Intensive patients are treated with extensive invasive procedures, which may cause a risk of hospital infections in 10–30% of the cases. Use sterile water for intensive care patients for oral hygiene. keywords: bacteria; care; control; hospital; hygiene; icu; infections; patients; room; unit; use cache: cord-016208-u12ngkpc.txt plain text: cord-016208-u12ngkpc.txt item: #326 of 2876 id: cord-016211-8j8n9enn author: Lu, Puxuan title: Highly Pathogenic Avian Influenza date: 2015-04-30 words: 9574 flesch: 48 summary: Isolation of avian infl uenza virus from respiratory specimens such as nasopharyngeal secretion and tracheal aspiration is the classical way to defi ne the diagnosis of human infection by avian infl uenza. H7N9 is a subtype of avian infl uenza virus that is categorized into the family of Orthomyxoviridae . keywords: blood; cases; human; infection; infl uenza; lesions; lung; onset; patients; pulmonary; shadow; stage; symptoms; virus cache: cord-016211-8j8n9enn.txt plain text: cord-016211-8j8n9enn.txt item: #327 of 2876 id: cord-016235-2lhrkmrv author: Roden, Anja C. title: Lung date: 2010-05-17 words: 12880 flesch: 33 summary: The effect of recipient's age on lung transplant outcome Pretransplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study Gastroesophageal reflux disease in lung transplant recipients Lung homotransplantation in man Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis Prospective analysis of 1, 235 transbronchial lung biopsies in lung transplant recipients Rejection is reduced in thoracic organ recipients when transplanted in the first year of life C4d deposition in lung allografts is associated with circulating anti-HLA alloantibody Acute and chronic onset of bronchiolitis obliterans syndrome (BOS): are they different entities? Anti-HLA class I antibody binding to airway epithelial cells induces production of fibrogenic growth factors and apoptotic cell death: a possible mechanism for bronchiolitis obliterans syndrome Pleural effusion from acute lung rejection Refining the identification of discriminatory genes for rejection in lung transplantation: the largo study Significance of a solitary perivascular mononuclear infiltrate in lung allograft recipients with mild acute cellular rejection Native lung complications in single-lung transplant recipients and the role of pneumonectomy Immunodeficiency-associated lymphoproliferative disorders Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders The US experience with lung transplantation for pulmonary lymphangioleiomyomatosis The diagnosis of obliterative bronchiolitis after heart-lung and lung transplantation: low yield of transbronchial lung biopsy Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant Lung transplantation at Duke University Medical Center Pulmonary inflammation after lung transplantation The incidence of cancer in patients with idiopathic pulmonary fibrosis and sarcoidosis in the UK Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: a distinct entity? Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants GI complications after orthotopic lung transplantation B-cell posttransplant lymphoproliferative disorders in heart and/or lungs recipients: clinical and molecular-histogenetic study of 17 cases from a single institution C3d and the septal microvasculature as a predictor of chronic lung allograft dysfunction Selection and evaluation of recipients for heart-lung and lung transplantation Outcomes of lung transplantation in patients with scleroderma Complications (excluding hyperinflation) involving the native lung after single-lung transplantation: incidence, radiologic features, and clinical importance Evolving strategies in lung transplantation for emphysema Surveillance bronchoscopy in lung transplant recipients: risk versus benefit Clinical implications and longitudinal alteration of peripheral blood transcriptional signals indicative of future cardiac allograft rejection Lung transplantation: a decade of experience Acute humoral rejection of human lung allografts and elevation of C4d in bronchoalveolar lavage fluid Lung transplantation for end-stage pulmonary sarcoidosis: outcome in a series of seven consecutive patients Pulmonary hypertension in patients with bronchiolitis obliterans syndrome listed for retransplantation Epstein-Barr virus-negative post-transplant lymphoproliferative disorders: a distinct entity? Lymphomas after solid organ transplantation: a collaborative transplant study report General overview of lung transplantation and review of organ allocation Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation Bronchoalveolar lavage cell gene expression in acute lung rejection: development of a diagnostic classifier Lung transplantation for lymphangioleiomyomatosis The changing pattern of posttransplant malignancies Does human leukocyte antigen matching influence the outcome of lung transplantation? Several host genetic characteristics have been suggested to modulate acute lung rejection. keywords: acute; allograft; bronchiolitis; chronic; diagnosis; disease; grade; heart; hla; infection; injury; lung; lung transplantation; patients; posttransplantation; pulmonary; recipients; rejection; risk; study; transplantation; years cache: cord-016235-2lhrkmrv.txt plain text: cord-016235-2lhrkmrv.txt item: #328 of 2876 id: cord-016237-sk1wzghx author: Zhang, Chen title: Infectious Diseases date: 2018-09-07 words: 1492 flesch: 24 summary: Pathological diagnosis of granulomatous lung disease: a review Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections Granulomatous reaction to Pneumocystis jirovecii: clinicopathologic review of 20 cases In: Katzenstein and Askin's surgical pathology of non-neoplastic lung disease Rhodococcus equi pneumonia and pulmonary malakoplakia in acquired immunodeficiency syndrome. Aspergillomas form in immunocompetent patients with underlying cavitary or cystic lung disease. keywords: disease; infections; lung; patients cache: cord-016237-sk1wzghx.txt plain text: cord-016237-sk1wzghx.txt item: #329 of 2876 id: cord-016248-dxk0i6t7 author: Papa, Joey C. title: Extracorporeal Membrane Oxygenation date: 2009 words: 6914 flesch: 47 summary: Any progression or change in neurologic status requires cessation of anticoagulation and thus removal from ECMO support. Oliguria and a slight rise in creatinine are common in ECMO patients and are often seen during the fi Hypertension should be aggressively treated due to the increased risk of intracerebral hemorrhage in ECMO patients. keywords: blood; circuit; ecmo; failure; membrane; oxygen; oxygenator; patients; pump; support; venous cache: cord-016248-dxk0i6t7.txt plain text: cord-016248-dxk0i6t7.txt item: #330 of 2876 id: cord-016280-d47e3art author: Friedberg, Joseph S. title: Pleura: Anatomy, Physiology, and Disorders date: 2008 words: 14507 flesch: 42 summary: Baltimore: Lippincott Williams and Wilkins Solitary fibrous tumor of the pleura The role of Alimta in the treatment of malignant pleural mesothelioma: an overview of preclinical and clinical trials Malignant mesothelioma-the UK experience Malignant pleural mesothelioma New developments about the association of SV40 with human mesothelioma Multimodality management of malignant pleural mesothelioma Gene expression profiles predict survival and progression of pleural mesothelioma Chemotherapy for malignant pleural mesothelioma: past results and recent developments Chemotherapy for malignant pleural mesothelioma: past results and recent developments Phase IT trial of pleural photodynamic therapy and surgery for patients with non-smallcell lung cancer with pleural spread Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): identification of five groups with different survival Prognostic value of pleural effusion in patients with non-small cell lung cancer Revisions in the International System for Staging Lung Cancer Indications for pleurectomy in malignant effusion Neoadjuvant chemotherapy and operations in the treatment of lung cancer with pleural effusion Malignant pleural effusion in non-small cell lung cancer-time for a stage revision Multimodality treatment programs for malignant pleural mesothelioma using highdose hemithorax irradiation Extrapleural pneumonectomy for lung cancer with carcinomatous pleuritis Prognosis of resected non-small cell lung cancer patients with carcinomatous pleuritis of minimal disease Implications of staging in lung cancer Intraoperative intrapleural hypotonic cisplatin treatment for carcinomatous pleuritis Pleuropneumonectomy and postoperative adjuvant chemotherapy for carcinomatous pleuritis in primary lung cancer: a case report of long-term survival Comparison of pleuropneumonectomy and limited surgery for lung cancer with pleural dissemination Phase IT trial of pleural photodynamic therapy and surgery for patients with non-smallcell lung cancer with pleural spread Gray's Anatomy Minimal Access Surgery in Oncology Chemical pleurodesis for malignant pleural effusion Comparison of thoracic drainage vs. immediate or delayed needle aspiration Treatment of pneumothoraces utilizing small caliber chest tubes The performance of four pleural drainage systems in an animal model of bronchopleural fistula Focal reexpansion pulmonary edema after drainage of large pleural effusions: clinical evidence suggesting hypoxic injury to the lung as the cause of edema Reexpansion pulmonary edema Complications in Cardiothoracic Surgery Smoking and the increased risk of contracting spontaneous pneumothorax Treatment of spontaneous pneumothorax: a more aggressive approach? Management of spontaneous pneumothorax Secondary spontaneous pneumothorax Significance of iatrogenic pneumothoraces Pulmonary Diseases and Disorders Pleural effusions: the diagnostic separation of transudates and exudates Focal reexpansion pulmonary edema after drainage of large pleural effusions: clinical evidence suggesting hypoxic injury to the lung as the cause of edema Transudative effusions Hepatic hydrothorax Outcome analysis of cirrhotic patients undergoing chest tube placement Recurrent pleural effusion complication liver cirrhosis Cytologically proved malignant pleural effusions: distribution of transudates and exudates Management of malignancyassociated pleural effusion: current and future treatment strategies Efficacy of short term versus long term tube thoracostomy drainage before tetracycline pleurodesis in the treatment of malignant pleural effusions Distribution of talc suspension during treatment of malignant pleural effusion with talc pleurodesis Pleurodesis for malignant pleural effusions (Cochrane Review) Outpatient management of malignant pleural effusion by a chronic indwelling catheter Survival and talc pleurodesis in metastatic pleural carcinoma, revisited. keywords: air; cancer; cavity; chest; chest tube; disease; drainage; effusion; fluid; lung; patient; pleura; pleurodesis; pneumothorax; pressure; pulmonary; space; surgery; treatment; tube cache: cord-016280-d47e3art.txt plain text: cord-016280-d47e3art.txt item: #331 of 2876 id: cord-016300-vw11c2wt author: Jain, Kewal K. title: Biomarkers of Pulmonary Diseases date: 2017-09-18 words: 5584 flesch: 38 summary: Lung ECM remodeling in healthy controls and COPD patients was investigated in the COPDGene study. One study was done to quantify bronchial lavage (BAL) fluid and serum levels of IL-8, secretory leukocyte protease inhibitor (SLPI), soluble intracellular adhesion molecules-1 (sICAM-1) and sCD14, as surrogate markers of inflammatory and immune response in asthma and COPD patients with similar disease duration time (Hollander et al. 2007 ). keywords: airway; asthma; biomarkers; copd; disease; function; inflammation; levels; lung; patients; serum cache: cord-016300-vw11c2wt.txt plain text: cord-016300-vw11c2wt.txt item: #332 of 2876 id: cord-016301-vqmqnipq author: Winnick, Aaron M. title: Elderly Transplant Recipients date: 2011-01-25 words: 11468 flesch: 38 summary: Age and immune response in organ transplantation Immunosuppression of the elderly kidney transplant recipient Rejection and recipient age Use of mycophenolate mofetil in immunosuppressive protocols in elderly renal transplant recipients Mycophenolate mofetil vs. azathioprine in a large population of elderly renal transplant patients Immunosuppression: evolution in practice and trends Risk factors for development of new-onset diabetes mellitus after kidney transplantation A calcineurin antagonist-free induction/maintenance strategy for immunosuppression in elderly recipients of renal allografts from elderly cadaver donors: long-term results from a prospective single centre trial Long-term results of calcineurin-free protocols with basiliximab induction in old-toold programs Preferential allocation of marginal kidney allografts to elderly recipients combined with modified immunosuppression gives good results Early mortality rates in older kidney recipients with comorbid risk factors Renal transplantation in the elderly: surgical complications and outcome with special emphasis on the Eurotransplant Senior Programme Liver transplantation trends for older recipients: regional and ethnic variations Chronic liver disease in the extremely elderly of 80 years or more: clinical characteristics, prognosis and patient survival analysis Liver transplantation in patients over sixty years of age Orthotopic liver transplantation in patients 60 years of age and older Orthotopic liver transplantation in patients over 60 years old Liver transplantation in patients over 60 years of age Liver transplantation in patients over sixty years of age Liver transplantation in patients over 60 and 65 years: an evaluation of long-term outcomes and survival Liver transplant for the septuagenarians: importance of patient selection Minimal criteria for placement of adults on the liver transplant waiting list: a report of a national conference organized by the American Society of Transplant Physicians and the American Association for the Study of Liver Diseases MELD and PELD: application of survival models to liver allocation Predicting outcome after liver transplantation: utility of the model for endstage liver disease and a newly derived discrimination function Impact of age older than 60 years in living donor liver transplantation Older age and liver transplantation: a review The prevalence of coronary artery disease in liver transplant candidates over age 50 The elderly liver transplant recipient: a call for caution Liver transplant recipients older than 60 years have lower survival and higher incidence of malignancy Allograft survival following adult-to-adult living donor liver transplantation Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium Long-term results of liver transplantation in older patients 60 years of age and older Liver transplantation in patients beyond age 60 Liver transplantation in recipients over 60 Similar outcomes, morbidity, and mortality for orthotopic liver transplantation between the very elderly and the young Evolution of liver transplantation in Europe: report of the European Liver Transplant Registry Prognostic model for early acute rejection after liver transplantation Age and liver transplantation: a report of the Liver Transplantation Database Transplantation in the elderly patient The registry of the International Society for Heart and Lung Transplantation: twentieth official adult heart transplant report -2003 Heart transplantation in patients seventy years of age and older: a comparative analysis of outcome Long-term survival (>10 years) of patients >60, years with induction therapy after cardiac transplantation Long-term results of heart transplantation in patients older than 60 years Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates -2006 Selection and treatment of candidates for heart transplantation. Heart transplantation in older candidates A comparative analysis of outcome after heart transplantation in patients aged 60 years and older: the University of Alberta experience Long-term outcomes of heart transplantation in older recipients Poor prognosis of heart transplant patients with end-stage renal failure Incidence of malignancies in heart and/or lung transplant recipients: a single-institution experience Registry of the International Society for Heart and Lung Transplantation: twentyfifth official adult lung and heart/lung transplantation report -2008 Assessment of survival benefit after lung transplantation by patient diagnosis Listing for lung transplantation: life expectancy and transplant effect, stratified by type of end-stage lung disease, the Eurotransplant experience International guidelines for the selection of lung transplant candidates: 2006 update -a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation Induction immunosuppression for lung transplantation with OKT3 Induction therapy in lung transplantation: a prospective, controlled clinical trial comparing OKT3, anti-thymocyte globulin, and daclizumab Registry of the International Society for Heart and Lung Transplantation: twentyfourth official adult lung and heart-lung transplantation report -2007 Impact of advanced age in lung transplantation: an analysis of United Network for Organ Sharing data Primary graft dysfunction and other selected complications of lung transplantation: a single-center experience of 983 patients Post-transplant bronchiolitis obliterans Development of malignancy following lung transplantation keywords: age; disease; donor; failure; heart; kidney; liver; lung; patients; recipients; rejection; renal; risk; survival; therapy; transplantation; years cache: cord-016301-vqmqnipq.txt plain text: cord-016301-vqmqnipq.txt item: #333 of 2876 id: cord-016308-qzkcwrit author: Cochran, Christina L. title: Neonatal Emergencies date: 2015-11-06 words: 2767 flesch: 41 summary: -Risk factors for infection include prolonged rupture of membranes, maternal fever, maternal infection, and lack of appropriate treatment for maternal GBS. • Prevention of hyperbilirubinemia focuses on appropriate hydration of the newborn and appropriate treatment of maternal infections at the time of delivery. keywords: blood; history; hyperbilirubinemia; infection; maternal; neonatal; newborns; patients; table cache: cord-016308-qzkcwrit.txt plain text: cord-016308-qzkcwrit.txt item: #334 of 2876 id: cord-016372-opojt70e author: DiMarco, Ross F. title: Postoperative Care of the Cardiac Surgical Patient date: 2010 words: 26969 flesch: 39 summary: Mechanisms, predictive factors, and prognostic significance Cardiac surgery Hemodynamic advantage to left atrial epinephrine administration in open heart surgery Lack of renoprotective effects of dopamine and furosemide during cardiac surgery Dopamine therapy for patients at risk of renal dysfunction following cardiac surgery: fact or fiction? Dobutamine and dopamine after cardiac surgery: greater augmentation of myocardial blood flow with dobutamine Effects of dobutamine on hemodynamic and left ventricular performance after cardiopulmonary bypass in cardiac surgical patients The comparative effects of dopamine and dobutamine on ventricular mechanics after coronary artery grafting: a pressure-dimension analysis Hemodynamic comparison of dopamine and dobutamine in the postoperative volume-loaded, pressure-loaded, and normal ventricle Use of amrinone in cardiac surgery patients The effects of amrinone versus dobutamine on myocardial mechanics after hypothermic global ischemia A randomized, blinded trial of amrinone, epinephrine, and amrinone/epinephrine after cardiopulmonary bypass (CPB) Combination high dose amrinone and dopamine in the management of moribund cardiogenic shock after open heart surgery Combined inotropic effects of amrinone and epinephrine after cardiopulmonary bypass in humans Pharmacology of bipyridines: amrinone and milrinone The effect of milrinone on hemodynamics and left ventricular function after emergence from cardiopulmonary bypass A single dose of milrinone facilitates separation from cardiopulmonary bypass in patients with pre-existing left ventricular dysfunction Direct vasodilator effect of milrinone, an inotropic drug, on arterial coronary bypass grafts Vasorelaxant effect of the phosphodiesteraseinhibitor milrinone in the human radial artery used as coronary bypass graft Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension Right ventricular dysfunction in low output syndrome after cardiac operations: assessment by transesophageal echocardiography Postoperative Care of the Cardiac Surgical Patient Perioperative use of nesiritide in adult cardiac surgery Nesiritide (BNP) in the management of postoperative cardiac patients Inhaled nitric oxide. keywords: artery; bleeding; blood; bypass; cardiac; cardiopulmonary; cpb; dose; dysfunction; effect; failure; fibrillation; function; heart; heparin; left; mcg; min; output; oxygen; patients; platelet; postoperative; pressure; rate; result; support; surgery; therapy; treatment; ventricular cache: cord-016372-opojt70e.txt plain text: cord-016372-opojt70e.txt item: #335 of 2876 id: cord-016413-lvb79oxo author: Efthimiou, Petros title: Adult-Onset Still’s Disease date: 2018-07-14 words: 6129 flesch: 38 summary: Myocarditis, pericarditis, and pleural effusions have also been observed in AOSD patients, and they seem to respond to anti-inflammatory treatment. Several retrospective case series and one open-labeled prospective randomized trial have evaluated the use of anakinra in AOSD patients [41, 42] . keywords: adult; anakinra; aosd; arthritis; cases; disease; fever; macrophage; onset; patients; symptoms; syndrome; treatment cache: cord-016413-lvb79oxo.txt plain text: cord-016413-lvb79oxo.txt item: #336 of 2876 id: cord-016460-39yniw0t author: Ben-Chetrit, Eldad title: Colchicine date: 2018-07-31 words: 9583 flesch: 39 summary: The pharmacologic basis of treatment with colchicine in children with familial Mediterranean fever Mechanism of the anti-inflammatory effect of colchicine in rheumatic diseases: a possible new outlook through microarray analysis Gout-associated uric acid crystals activate the NALP3 inflammasome Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a rationale for use of low-dose colchicine Innate immune sensing of bacterial modifications of Rho GTPases by the pyrin inflammasome Interaction of pyrin with 14.3.3 in an isoform-specific and phosphorylation-dependent manner regulates its translocation to the nucleus Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS Technical advance: inhibition of neutrophil chemotaxis by colchicine is modulated through viscoelastic properties of subcellular compartments Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells The effects of colchicine on the progression and regression of encapsulating peritoneal sclerosis Colchicine use in children and adolescents with familial Mediterranean fever: literature review and consensus statement Colchicine is a safe drug in children with familial Mediterranean fever Current trends in colchicine treatment in familial Mediterranean fever Colchicine intoxication clinical pharmacology, risk factors, features and management Colchicine: old and new Estimation of colchicine in a poisoned patient by using high performance liquid chromatography Treatment of severe colchicine overdose with colchicine specific fab fragments Vos FR high flux dialysis membranes improve lipid profile in chronic hemodialysis patients Colchicine clearance by high-flux polysulfone dialyzers ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions Colchicine myotoxicity: case reports and literature review Colchicine use in cyclosporine treated transplant recipients: how little is too much? MDR-and CYP3A4-mediated drug-drug interactions Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4 Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions Acute myopathy in a patient with concomitant use of pravastatin and colchicine Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study Cytoskeletal myotoxicity from simvastatin and colchicine Rhabdomyolysis in a patient treated with colchicine and atorvastin Possible colchicine rhabdomyolysis in a fluvastatin-treated patient Novel evidence-based colchicine dosereduction algorithm to predict and prevent colchicine toxicity in the presence of cytochrome P450 Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor Colchicineinduced lactose malabsorption in patients with familial Mediterranean fever Azoospermia caused by colchicine-a case report The effect of colchicine on the spermatogenesis of rabbits A cytogenetic evaluation of long term colchicines therapy in the treatment of familial Mediterranean fever (FMF) Testicular function in patients with familial Mediterranean fever, long-term colchicine treatment Fertility and obstetric history in patients with familial Mediterranean fever on long term colchicine therapy The effect of colchicine on human spermatozoal motility in vitro Colchicine and testicular function in man Urological evaluation of Behçet patients and the effect of colchicine on fertility Azoospermia in FMF patients-the role of colchicine and amyloidosis Daily prophylactic colchicines in familial Mediterranean fever The effect of FMF and colchicine on pregnancies outcome of wives of patients with FMF Familial Mediterranean fever and menstruation Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women Qualitative study of the interaction mechanism of estrogenic drugs with tubulin Safety of colchicine therapy during pregnancy Familial Mediterranean fever and its implications for fertility and pregnancy Colchicine treatment in conception and pregnancy: two hundred and thirty one pregnancies in patients with familial Mediterranean fever Pregnancy outcome after in utero exposure to colchicine Outcome of pregnancies in FMF women with colchicine Breast feeding during colchicine therapy for familial Mediterranean fever Colchicine in breast-milk of patients with FMF Colchicine treatment in familial Mediterranean fever (FMF)-reappraisal after 15 years Colchicine therapy of children with FMF (abstract) Growth and IGF-1 levels of children with familial Mediterranean fever on colchicine treatment EULAR recommendations for the management of familial Mediterranean fever Familial Mediterranean fever is no longer a rare disease in Japan Evidencebased recommendations for the practical management of familial Mediterranean fever Comparison of the efficacy of once-and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever-a randomized controlled non-inferiority trial High versus low dosing of oral colchicine for early acute gout flare: twenty-four-hour outcome of the first multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-comparison colchicine study American College of Rheumatology guidelines for management of gout. When abdominal cramps persist, lowering colchicine dose may be effective. keywords: acute; cells; colchicine; disease; dose; drug; effect; fever; fmf; gout; liver; mediterranean; microtubules; patients; pyrin; study; therapy; treatment; tubulin cache: cord-016460-39yniw0t.txt plain text: cord-016460-39yniw0t.txt item: #337 of 2876 id: cord-016476-78r0rsio author: Jani, Meghna title: Management of the Rheumatoid Arthritis Patient with Interstitial Lung Disease date: 2017-11-29 words: 15259 flesch: 30 summary: Abatacept can be used safely for RA patients with interstitial lung disease Risk of hospitalised infection in rheumatoid arthritis patients receiving biologics following a previous infection while on treatment with anti-TNF therapy American College of Rheumatology guideline for the treatment of rheumatoid arthritis Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study) Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebocontrolled, randomised trial Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA) Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY part a trial Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a phase III study A case of organizing pneumonia induced by tocilizumab A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab Exacerbation of combined pulmonary fibrosis and emphysema syndrome during tocilizumab therapy for rheumatoid arthritis Acute pneumonitis in a patient with adult-onset disease after toclizumab treatment with good response to anakinra Interstitial lung disease in rheumatoid arthritis: response to IL-6R blockade Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan: interim analysis of 3881 patients Association of disease activity with acute exacerbation of interstitial lung disease during tocilizumab treatment in patients with rheumatoid arthritis: a retrospective, case-control study Recombinant human interleukin-1 receptor type I in the treatment of patients with active rheumatoid arthritis Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Whilst mortality rates have been reported up to 17%, hypersensitivity pneumonitis is reported to be a rare AE in RA patients. keywords: arthritis; case; disease; drug; ild; lung; lung disease; methotrexate; mtx; patients; pneumonitis; rheumatoid; rheumatoid arthritis; risk; rituximab; safety; study; therapy; treatment cache: cord-016476-78r0rsio.txt plain text: cord-016476-78r0rsio.txt item: #338 of 2876 id: cord-016478-gpl0zbvd author: Barry, Maura title: Cytopenias in Transplant Patients date: 2018-12-08 words: 5640 flesch: 26 summary: Solid organ transplant recipients are at risk for developing infections due to their medically induced immunodeficiency following transplant, required to prevent rejection of the transplanted organ. Solid organ transplant recipients are at risk for developing infections due to their immunosuppression, and viral infections in particular are a potential contributor to the development of thrombocytopenia following solid organ transplant. keywords: anemia; infection; leukopenia; liver; organ; patients; recipients; renal; solid; thrombocytopenia; transplant; transplantation cache: cord-016478-gpl0zbvd.txt plain text: cord-016478-gpl0zbvd.txt item: #339 of 2876 id: cord-016498-j72vrvqf author: Fong, I. W. title: Issues in Community-Acquired Pneumonia date: 2020-03-07 words: 8292 flesch: 36 summary: Moreover, neutrophils from severe CAP patients showed reduced respiratory burst activity compared to the non-severe group. In a prospective multicenter cohort study of 4070 hospitalized CAP patients, 37.6% presented with severe sepsis [42] . keywords: adults; analysis; cap; children; community; mortality; patients; pneumonia; respiratory; review; risk; studies; study; treatment cache: cord-016498-j72vrvqf.txt plain text: cord-016498-j72vrvqf.txt item: #340 of 2876 id: cord-016521-ouwwkxox author: Stevens, Jennifer P. title: Ventilator-Associated Pneumonia and Other Complications date: 2016-07-21 words: 3343 flesch: 27 summary: The CDC Prevention Epicenters Wake Up and Breathe Collaborative Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously A comparison of four methods of weaning patients from mechanical ventilation. key: cord-016521-ouwwkxox authors: Stevens, Jennifer P.; Howell, Michael D. title: Ventilator-Associated Pneumonia and Other Complications date: 2016-07-21 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-319-43341-7_29 sha: doc_id: 16521 cord_uid: ouwwkxox Ventilator-associated pneumonia occurs in patients who have been intubated for two to three days with significant exposure to hospital-acquired organisms. keywords: patients; pneumonia; risk; study; therapy; trial; vap; ventilator cache: cord-016521-ouwwkxox.txt plain text: cord-016521-ouwwkxox.txt item: #341 of 2876 id: cord-016559-tqd7m2i1 author: Zheng, Yi title: Application in Medicine Systems date: 2014-10-28 words: 19358 flesch: 48 summary: Xing [8] reported the application of CDI in the treatment of 120 patients (treatment group: 80 patients, control group: 40 patients) with coronary heart disease and angina pectoris and blood stasis based on temporal rhythm. The results showed that there were 2 cases with a clinical cure, 8 cases with marked effect, 10 cases with improvement, 7 cases without effect, and the total effective rate was 91 % in treatment group. keywords: blood; cases; cdi; compound danshen; control group; danshen; danshen injection; danshen treatment; day; days; disease; drip; effect; function; groups; heart; injection; patients; rate; results; total; treatment group cache: cord-016559-tqd7m2i1.txt plain text: cord-016559-tqd7m2i1.txt item: #342 of 2876 id: cord-016572-6fu5s89c author: Hage, Chadi A. title: Endemic mycosis date: 2005 words: 9006 flesch: 41 summary: In fact, most cases of PDH now occur in AIDS patients, and most occur in highly endemic areas [22] , [23] . In AIDS patients with PDH, the density of organisms is higher than in other immunosuppressed patients, and blood cultures are particularly useful, yielding a diagnosis in up to 90% of cases. keywords: aids; amphotericin; blastomycosis; cases; coccidioidomycosis; diagnosis; disease; histoplasmosis; illness; infection; itraconazole; patients; pdh; pulmonary; therapy; treatment cache: cord-016572-6fu5s89c.txt plain text: cord-016572-6fu5s89c.txt item: #343 of 2876 id: cord-016601-gp259urb author: Bonadonna, Lucia title: Analysis of Microorganisms in Hospital Environments and Potential Risks date: 2017-03-24 words: 3525 flesch: 25 summary: Some biofilm-forming bacteria such as Legionella, Klebsiella, Pantoea agglomerans, Acinetobacter baumannii and Enterobacter cloacae can cause hospital infections and are more resistant to disinfectants and antibiotics than their planktonic states. The definition of the role that the environment has on the acquisition of hospital infections is highlighted by the need for multiple strategies to control the dissemination of pathogenic microorganisms and the adoption of prevention measures. keywords: air; healthcare; hospital; indoor; infections; microorganisms; pathogens; patients; surfaces; water cache: cord-016601-gp259urb.txt plain text: cord-016601-gp259urb.txt item: #344 of 2876 id: cord-016757-3d320c0a author: None title: Acute and chronic liver insufficiency date: 2008 words: 9789 flesch: 40 summary: Clinical features, etiology, epidemiology, and current management Serum phosphorus levels predict clinical outcome in fulminant hepatic failure Plasma phospholipids fatty acid pattern in severe liver disease Fulminant hepatic failure as a presenting paraneoplastic manifestation of Hodgkin's disease Controlled hyperventilation in the prevention of cerebral oedema in fulminant hepatic failure Prognostic indicators in acute liver failure Fulminant hepatic failure in nonmetastatic renal cell carcinoma Fulminant Epstein-Barr viral hepatitis: orthotopic liver transplantation and review of the literature Insulin and glucagon levels in fulminant hepatic failure in man Prognostic indicators in fulminant hepatic failure Insulin and Glucagon therapy of acute hepatic failure Miliary tuberculosis presenting as hepatic and renal failure Fulminant hepatic failure after occupational exposure to 2-nitropropane Chemotherapy of Amanita phalloides poisoning with intravenous silibinin Activin A and follistatin in acute liver failure Fulminant hepatic failure caused by tuberculosis Fulminant or subfulminant non-A, non-B viral hepatitis: the role of hepatitis C and E viruses Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension Fulminant hepatic failure due to secondary amyloidosis Pilot study with polyenylphosphatidylcholine in severe liver insufficiency Controlled trial of antithrombin III supplementation in fulminant hepatic failure Intracranial pressure monitoring and liver transplantation for fulminant hepatic failure Ratio of circulating follistatin and activin A reflects the severity of acute liver injury and prognosis in patients with acute liver failure The fulminant form of epidemic hepatitis Fulminant hepatic failure as the initial manifestation of primary hepatocellular carcinoma Fulminant hepatic failure with massive necrosis as a result of hepatitis A infection Early changes in the permeability of the blood-brain barrier produced by toxins associated with liver failure Spontaneous reactivation of chronic hepatitis B infection leading to fulminant hepatic failure Hepatic regeneration in fulminant hepatic failure Renal failure in acute liver failure Caffeine clearance and galactose elimination capacity as prognostic indicators in fulminant hepatic failure Autoimmune hepatitis presenting with acute hepatic failure Fulminant hepatic failure caused by acute fatty liver of pregnancy treated by orthotopic liver transplantation Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators The management of abnormalities of hemostasis in acute liver failure Activation of the fibrinolytic system in patients with fulminant liver failure Vorgehen bei Knollenblätterpilzvergiftung Fulminant hepatic failure after Lepiota mushroom poisoning Bacterial and fungal infection in acute liver failure L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure Acute carbon tetrachloride poisoning in 19 patients: implications for diagnosis and treatment Selective intestinal decontamination in the prevention of bacterial infection in patients with acute liver failure Acute liver failure due to non-Hodgkin's lymphoma Efficacy of hepatic arterial infusion of prostaglandin E1 in the treatment of postoperative acute liver failure. Ϫ Report of a case Gc-globulin and prognosis in acute liver failure Energy metabolism in acute hepatic failure Prognostic value of hepatic volumetry in fulminant hepatic failure The pathophysiological basis of acuteon-chronic liver failure Variants of hepatitis B virus associated with fulminant liver disease Acute liver failure: clinical features, outcome analysis, and applicability of prognostic criteria Treatment of fulminant hepatic failure with intravenous prostaglandin E1 Brain edema in liver failure: basic physiologic principles and management Hyperventilation restores cerebral blood flow autoregulation in patients with acute liver failure Cerebral metabolism of ammonia and amino acids in patients with fulminant hepatic failure Prospective assessment of incidence of fulminant hepatitis in post-transfusion hepatitis: a study of 504 cases Fulminant hepatitis A virus infection in the United States: Incidence, prognosis, and outcomes Role of hepatitis C virus in German patients with fulminant and subfulminant hepatic failure Fulminante Hepatitis bei Listeriensepsis Fulminant herpes hepatitis in a healthy adult. keywords: acute; blood; cerebral; chronic; coma; disease; failure; function; hepatic; hepatitis; hepatocytes; insufficiency; liver; liver failure; patients; system; time; transplantation; treatment cache: cord-016757-3d320c0a.txt plain text: cord-016757-3d320c0a.txt item: #345 of 2876 id: cord-016814-tf17dpo5 author: Enes, Sara Rolandsson title: Clinical Application of Stem/Stromal Cells in COPD date: 2019-08-07 words: 10760 flesch: 35 summary: Effects of freeze-thawing and intravenous infusion on mesenchymal stromal cell gene expression Freshly thawed and continuously cultured human bone marrow-derived mesenchymal stromal cells comparably ameliorate allergic airways inflammation in immunocompetent mice Attachment, growth, and detachment of human mesenchymal stem cells in a chemically defined medium Collagen promotes higher adhesion, survival and proliferation of mesenchymal stem cells The extracellular matrixthe under-recognized element in lung disease? Comprehensive review of the recent literature 2010-2012 Mitochondrial transfer between cells can rescue aerobic respiration Cell-tocell cross-talk between mesenchymal stem cells and cardiomyocytes in co-culture Mechanisms of mesenchymal stem/stromal cell function Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in vivo models of ARDS Mitochondria in mesenchymal stem cell biology and cell therapy: from cellular differentiation to mitochondrial transfer Mitochondrial dysfunction increases allergic airway inflammation Association between mitochondrial dysfunction and severity and outcome of septic shock Mitochondria in lung diseases Intra-and intercellular quality control mechanisms of mitochondria Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs Monocyte/macrophage-derived microparticles up-regulate inflammatory mediator synthesis by human airway epithelial cells CD18-mediated adhesion is required for the induction of a proinflammatory phenotype in lung epithelial cells by mononuclear cell-derived extracellular vesicles Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation Extracellular vesicle-shuttled mRNA in mesenchymal stem cell communication Biological properties of extracellular vesicles and their physiological functions Exosomal miR-146a contributes to the enhanced therapeutic efficacy of interleukin-1beta-primed mesenchymal stem cells against sepsis Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis A phase 1b study of placentaderived mesenchymal stromal cells in patients with idiopathic pulmonary fibrosis Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smokeinduced damage Bone marrow mesenchymal stem cell transplantation for treatment of emphysemic rats Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors Therapeutic effects of amniotic fluid-derived mesenchymal stromal cells on lung injury in rats with emphysema IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype Impaired function of bone marrow mesenchymal stem cells from immune thrombocytopenia patients in inducing regulatory dendritic cell differentiation through the Notch-1/Jagged-1 signaling pathway Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma Activation of human mesenchymal stem cells impacts their therapeutic abilities in lung injury by increasing interleukin (IL)-10 and IL-1RN levels Serum from asthmatic mice potentiates the therapeutic effects of mesenchymal stromal cells in experimental allergic asthma The toll-like receptor 3 ligand, poly(I:C), improves immunosuppressive function and therapeutic effect of mesenchymal stem cells on sepsis via inhibiting MiR-143 Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts Hepatocyte growth factor-modified mesenchymal stem cells improve ischemia/reperfusioninduced acute lung injury in rats Transfection of mesenchymal stem cells with the FGF-2 gene improves their survival under hypoxic conditions Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1 Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression Promotion of survival and engraftment of transplanted adipose tissue-derived stromal and vascular cells by overexpression of manganese superoxide dismutase Mesenchymal stem cells overexpressing angiotensin-converting enzyme keywords: administration; bone; cells; copd; culture; disease; emphysema; human; lung; marrow; mesenchymal; mesenchymal stem; mscs; patients; pulmonary; stem; stromal; studies; study; tissue; treatment cache: cord-016814-tf17dpo5.txt plain text: cord-016814-tf17dpo5.txt item: #346 of 2876 id: cord-016871-1mlamf20 author: Streiff, Agathe title: Hemorrhage and Transfusions in the Surgical Patient date: 2012-10-30 words: 9061 flesch: 42 summary: The decision to transfuse such patients should weigh the bene fi ts and the risks of blood transfusions, especially given the patients' increased susceptibility to infections, iatrogenic events and increased metabolic demands [ 53 ] . Hemolytic reactions in blood transfusions occur because each individual carries antibodies against the blood group (A or B) that it does not express endogenously. keywords: bleeding; blood; coagulation; hemorrhage; mortality; patients; plasma; platelet; products; rbc; resuscitation; surgery; surgical; teg; transfusion; trauma cache: cord-016871-1mlamf20.txt plain text: cord-016871-1mlamf20.txt item: #347 of 2876 id: cord-016960-xhzvp35g author: Berencsi, György title: Fetal and Neonatal Illnesses Caused or Influenced by Maternal Transplacental IgG and/or Therapeutic Antibodies Applied During Pregnancy date: 2012-03-08 words: 17740 flesch: 31 summary: Experimental systemic lupus erythemetosus could be induced in mice using immunisation with anti-idiotype antibodies (Ab2) specific to the anti-DNA-specific monoclonal antibodies (Mendlovic et al. 1989) . MELIMMUNE: anti-idiotype antibody that mimic the high molecular weight chondroitin sulfate proteoglycan antigen of melanoma cells (Pride et al. 1998; Murray et al. 2004; keywords: activity; anti; antibodies; antibody; antigen; arthritis; associated; blood; cancer; cells; development; disease; et al; factor; growth; human; idiotype; igg; immune; infection; inflammatory; infliximab; lupus; monoclonal; mothers; necrosis; neonatal; nieri; nieri et; patients; pregnancy; receptor; rheumatoid; risk; sle; specific; study; syndrome; therapy; tnf; treatment; tumor; virus; women cache: cord-016960-xhzvp35g.txt plain text: cord-016960-xhzvp35g.txt item: #348 of 2876 id: cord-016973-s32jp0ej author: Menon, Nithya title: Respiratory Diseases of Pregnancy date: 2016-07-21 words: 2464 flesch: 38 summary: Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study Epidemiology of pregnancy-associated venous thromboembolism: a population-based study in Canada Pregnancy and the lungs Successful use of noninvasive ventilation in pregnancy Implications for the pregnant patient Mechanical ventilation during pregnancy: sedation, analgesia, and paralysis Systemic inflammatory response syndrome, organ failure, and outcome in critically ill obstetric patients treated in an icu Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic Modern use of extracorporeal life support in pregnancy and postpartum Prone positioning for ARDS following blunt chest trauma in late pregnancy How safe is the prone position in acute respiratory distress syndrome at late pregnancy Does delivery improve maternal condition in the respiratory-compromised gravida? key: cord-016973-s32jp0ej authors: Menon, Nithya; Reed, Mary Jane title: Respiratory Diseases of Pregnancy date: 2016-07-21 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-319-43341-7_89 sha: doc_id: 16973 cord_uid: s32jp0ej Respiratory complaints in the gravid patient are often difficult to identify as a disease state, expected physiologic changes of pregnancy or both. keywords: edema; patients; pregnancy; pressure; risk; use; ventilation cache: cord-016973-s32jp0ej.txt plain text: cord-016973-s32jp0ej.txt item: #349 of 2876 id: cord-016982-qt25tp6t author: Fong, I. W. title: Litigations for Unexpected Adverse Events date: 2010-11-30 words: 8379 flesch: 44 summary: There are two types of hepatic toxicity seen in INH; a common transient elevation of the transaminases seen in 10-30% of patients that occurs within 4-6 months and is benign and asymptomatic, and clinical hepatitis (symptomatic) which is much less common, age-related, and only occurs in about 1% of treated patients. In immunocompromised patients with VZV infection, later initiation of therapy (72 h after onset of rash) may be of value. keywords: adults; cases; chronic; dose; drug; effects; hepatitis; inh; liver; patient; risk; skin; therapy; treatment; tuberculosis; varicella cache: cord-016982-qt25tp6t.txt plain text: cord-016982-qt25tp6t.txt item: #350 of 2876 id: cord-017012-yl0vanuh author: Herberg, Jethro title: Infectious Diseases and the Kidney date: 2009 words: 23989 flesch: 30 summary: Bacterial infections associated with renal disease and the likely mechanisms causing renal dysfunction are shown in > Impaired renal function is a common occurrence in systemic sepsis (1) . The group A streptococci (GAS) are a major worldwide cause of renal disease, usually as poststreptococcal nephritis. keywords: acute; bkv; cases; cause; cells; children; chronic; diagnosis; disease; evidence; failure; features; fever; glomerular; hbv; hepatitis; hiv; illness; immune; infection; involvement; kidney; nephritis; nephropathy; patients; present; proteinuria; renal; shock; syndrome; therapy; treatment; urine; virus cache: cord-017012-yl0vanuh.txt plain text: cord-017012-yl0vanuh.txt item: #351 of 2876 id: cord-017016-twwa9djm author: Tomashefski, Joseph F. title: Aspiration, Bronchial Obstruction, Bronchiectasis, and Related Disorders date: 2008 words: 20063 flesch: 32 summary: A study of 36 cases with special reference to the pulmonary lesions The bronchial mucous glands-their hypertrophy and change in intracellular mucus Similarity of the tracheobronchial mucous glands and epithelium in infants with and without cystic fibrosis The innate immune system in cystic fibrosis lung disease The genesis of cystic fibrosis lung disease Pathogenesis of bacterial bronchitis in cystic fibrosis Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology How mutant CFTR may contribute to Pseudomonas aeruginosa infection in cystic fibrosis Lung infections associated with cystic fibrosis Bacterial infections and inflammation in the lungs of cystic fibrosis patients Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation Cystic fibrosis lung inflammation: early, sustained and severe Inflammatory cytokines in cystic fibrosis lungs Normal bronchial epithelial cells constitutively produce the antiinflammatory cytokine interleukin-lO, which is downregulated in cystic fibrosis Early pulmonary inflammation in infants with cystic fibrosis Cytokine secretion by cystic fibrosis airway epithelial cells Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. 279,28o It has long been recognized that patients with CF are predisposed to lung infection. keywords: abscess; acid; airway; aspiration; associated; bronchial; bronchiectasis; cases; cause; cells; chapter; children; chronic; ciliary; cystic; disease; fibrosis; fig; foreign; infection; inflammation; lipid; lobe; lung; lung abscess; lung disease; obstruction; patients; pneumonia; primary; pulmonary; study; syndrome; tissue; young cache: cord-017016-twwa9djm.txt plain text: cord-017016-twwa9djm.txt item: #352 of 2876 id: cord-017040-4zajnrsf author: Rihana, Nancy title: Skin Infections date: 2019-08-11 words: 6489 flesch: 34 summary: These environmental pathogens may cause skin infections that usually occur following trauma or surgical procedures and injections, which is usually not present in immunocompromised patients. There are two main types of cutaneous infections : primary cutaneous infections and cutaneous manifestations of a disseminated infection. keywords: cases; cause; cellulitis; diagnosis; fungal; infection; lesions; manifestations; neutropenic; nodules; patients; review; skin; treatment cache: cord-017040-4zajnrsf.txt plain text: cord-017040-4zajnrsf.txt item: #353 of 2876 id: cord-017105-mljywm9p author: Jain, Amisha title: Pulmonary Complications of Obstetric and Gynecologic Conditions date: 2017-10-24 words: 7734 flesch: 37 summary: There is a bidirectional interaction of asthma and pregnancy where asthma influences pregnancy outcomes and pregnancy affects asthma severity. However, the reproductive system can exert significant effects on the respiratory system as a result of the various hormonal changes that occur during a woman’s menstrual cycle and especially during pregnancy. keywords: asthma; changes; chest; diagnosis; disease; lam; lung; osa; patients; pneumothorax; pregnancy; pulmonary; respiratory; risk; treatment; women cache: cord-017105-mljywm9p.txt plain text: cord-017105-mljywm9p.txt item: #354 of 2876 id: cord-017142-vx3rgs4r author: Nair, Ranjit title: What the Intensivists Need to Know About Critically Ill Myeloma Patients date: 2019-07-09 words: 9346 flesch: 29 summary: In: Decision making in medicine A pilot randomised comparison of dexamethasone 96 mg vs 16 mg per day for malignant spinal-cord compression treated by radiotherapy: TROG 01.05 Superdex study Plasmablastic morphologyan independent prognostic factor with clinical and laboratory correlates: Eastern Cooperative Oncology Group (ECOG) myeloma trial E9486 report by the ECOG Myeloma Laboratory Group Light-chain cardiac amyloidosis: strategies to promote early diagnosis and cardiac response Outcome and incidence of appropriate implantable cardioverterdefibrillator therapy in patients with cardiac amyloidosis Hyperviscosity in plasma cell dyscrasias Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma Renal thrombotic microangiopathy and podocytopathy associated with the use of carfilzomib in a patient with multiple myeloma Bortezomib and heart failure: case-report and review of the French Pharmacovigilance database Risk of early mortality in patients with newly diagnosed multiple myeloma Multiple intraparenchymal brain plasmacytomas with spontaneous intratumoral hemorrhage Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis The pathogenesis and diagnosis of acute kidney injury in multiple myeloma Early reduction of serum-free light chains associates with renal recovery in myeloma kidney Immunosuppression and infection in multiple myeloma Discrimination of metastatic from acute osteoporotic compression spinal fractures with MR imaging Diffuse pulmonary parenchymal involvement in multiple myeloma: antemortem diagnosis Nonspecific interstitial pneumonitis after bortezomib and thalidomide treatment in a multiple myeloma patient Multiple myeloma with myelomatous pleural effusion: a case report and review of the literature Plasmapheresis in the treatment of renal failure associated with multiple myeloma Review of 1027 patients with newly diagnosed multiple myeloma Salmon calcitonin in the acute management of hypercalcemia Vertebral compression fractures in multiple myeloma Distribution and appearance at MR imaging Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer Narrative review: furosemide for hypercalcemia: an unproven yet common practice Use of abdominal fat tissue aspirate in the diagnosis of systemic amyloidosis Acute tubular necrosis in a patient with myeloma treated with carfilzomib Implantable cardioverter defibrillators in patients with cardiac amyloidosis A 2011 updated systematic review and clinical practice guideline for the management of malignant extradural spinal cord compression Multiple myeloma causing interstitial pulmonary infiltrates and softtissue plasmacytoma Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: an analysis of 10 549 patients from the International Myeloma Working Group Central nervous system involvement in multiple myeloma patients in the era of novel therapies (P07.005) Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials Effectiveness of radiation therapy without surgery in metastatic spinal cord compression: final results from a prospective trial Multiple myeloma invasion of the central nervous system Proliferative activity of myeloma cells determined by Ki-67 antibody: biological and clinical significance Acute respiratory distress syndrome due to pulmonary involvement by neoplastic plasma cells in multiple myeloma Hyperviscosity syndrome in plasma cell dyscrasias Acute pancreatitis secondary to hypercalcemia of multiple myeloma Effect of plasmapheresis on hyperviscosity-related retinopathy and retinal hemodynamics in patients with Waldenstrom's macroglobulinemia Cardiac amyloidosis and its new clinical phenotype: heart failure with preserved ejection fraction Corticosteroids as adjunctive therapy for diffuse alveolar hemorrhage associated with bone marrow transplantation Acute tachypnea during mechanical ventilation in a 62-year-old man with multiple myeloma involving the spinal cord Optimizing the management of patients with spinal myeloma disease Risk factors for early death in patients undergoing treatment for multiple myeloma Prophylactic low-dose aspirin is effective antithrombotic therapy for combination treatments of thalidomide or lenalidomide in myeloma Is elevated plasma B-natriuretic peptide in amyloidosis simply a function of the presence of heart failure? Infections in patients with multiple myeloma in the era of high-dose therapy and novel agents Unexpected cardiotoxicity in haematological bortezomib treated patients Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgenindependent prostate cancer Cerebral infarction in IgG multiple myeloma with hyperviscosity Meningeal and cerebral involvement in multiple myeloma patients Randomized phase II trial comparing different doses of the bisphosphonate ibandronate in the treatment of hypercalcemia of malignancy Efficacy and safety of ibandronate in the treatment of hypercalcemia of malignancy: a randomized multicentric comparison to pamidronate Continued survival gains in recent years among critically ill myeloma patients Acute respiratory distress syndrome with pulmonary calcification in two patients with B cell malignancies Immunodeficiency and immunotherapy in multiple myeloma Is surgery required in the management of spinal cord compression in myeloma patients? Despite having increased life expectancy now, the majority of MM patients ultimately develop resistant subclones, leading to disease progression and disease-related complications. keywords: acute; amyloidosis; bortezomib; cardiac; diagnosis; disease; failure; hypercalcemia; involvement; light; myeloma; patients; renal; risk; symptoms; syndrome; therapy; treatment cache: cord-017142-vx3rgs4r.txt plain text: cord-017142-vx3rgs4r.txt item: #355 of 2876 id: cord-017184-1ewi3dka author: None title: Primary Immunodeficiencies date: 2008 words: 44590 flesch: 43 summary: Therefore defects in BM prethymic T cell development can contribute to T cell deficiency in nu/nu mice [90] . T-cell proliferative responses to mitogens were defective and IL 2 R expression was deficient on his T lymphocytes, and B cells did not differentiate into antibodysecreting cells when provided with the help of normal T cells [245] . keywords: absence; age; b cells; bmt; bone; cases; cd8; cells; children; chromosome; chronic; class; clinical; combined; common; defect; deficiencies; deficiency; development; diagnosis; disease; expression; fig; function; gene; hla; ifn; iga; ige; igg; igm; immunodeficiency; infections; levels; life; lymphocyte; marrow; months; mutations; normal; patients; pid; present; primary; production; protein; recurrent; rris; scid; serum; severe; study; symptoms; syndrome; t cells; table; transplantation; treatment; years cache: cord-017184-1ewi3dka.txt plain text: cord-017184-1ewi3dka.txt item: #356 of 2876 id: cord-017217-zjab7o2o author: Ali, Yousaf title: Self Assessment Questions date: 2008-01-08 words: 9363 flesch: 52 summary: Pseudogout is typically seen in older patients with preexisting degenerative joint disease, metabolic disease, or hyperparathyroidism, and no crystals have been observed. Semin Dial Management of carpal tunnel syndrome in renal dialysis patients using an extended carpal tunnel release procedure Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis Pulmonary hypertension in systemic autoimmune disease A 41-year-old female is referred due to 4 years of recurrent sinusitis. keywords: bone; cause; diagnosis; disease; examination; female; hip; history; joint; negative; normal; pain; patient; questions; right; self; syndrome; therapy; treatment; year cache: cord-017217-zjab7o2o.txt plain text: cord-017217-zjab7o2o.txt item: #357 of 2876 id: cord-017227-66dx2dkv author: Humphreys, Hilary title: Immunocompromised Patients date: 2012-08-21 words: 4903 flesch: 33 summary: Clearly, the change in prognosis of HIV with HAART has led to a shift in management such that HIV patients are offered maximal treatment, including full ICU support, organ transplantation in the appropriate circumstances, or chemotherapy if needed. A thorough discussion of the management of HIV patients is beyond the scope of this book. keywords: aspergillosis; cancer; disease; hiv; icu; infection; neutrophil; patients; pcp; transplantation; treatment cache: cord-017227-66dx2dkv.txt plain text: cord-017227-66dx2dkv.txt item: #358 of 2876 id: cord-017252-88b3preq author: Morgan, Carrie I. title: Pneumonia date: 2014-02-20 words: 6427 flesch: 26 summary: This chapter will focus on pediatric community-acquired pneumonia (CAP), immunocompromised pneumonia, and aspiration pneumonia. This chapter will focus on pediatric community-acquired pneumonia (CAP), immunocompromised pneumonia, and aspiration pneumonia. keywords: aspiration; chest; children; community; empyema; infections; infl; patients; pleural; pneumonia; pulmonary; therapy; tract cache: cord-017252-88b3preq.txt plain text: cord-017252-88b3preq.txt item: #359 of 2876 id: cord-017302-xez0zso3 author: Stephens, R. Scott title: ICU Complications of Hematopoietic Stem Cell Transplant, Including Graft vs Host Disease date: 2019-07-24 words: 5227 flesch: 28 summary: National Institute of Allergy and Infectious Diseases Mycoses Study Group Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia Neutropenic enterocolitis: new insights into a deadly entity The prognostic impact of abdominal surgery in cancer patients with neutropenic enterocolitis: a systematic review and meta-analysis, on behalf the Groupe de Recherche en Reanimation Respiratoire du patient d'Onco-Hematologie (GRRR-OH) Acute respiratory distress syndrome in patients with malignancies Acute respiratory distress syndrome during neutropenia recovery Pulmonary complications of bone marrow transplantation Outcomes of stem cell transplant patients with acute respiratory failure requiring mechanical ventilation in the United States Epidemiology of acute respiratory distress syndrome following hematopoietic stem cell transplantation Pulmonary infections complicating hematological disorders Febrile neutropenia: significance of elaborated screening for respiratory viruses, and the comparison of different sampling methods, in neutropenic patients with hematological malignancies Viral pneumonia in patients with hematologic malignancy or hematopoietic stem cell transplantation Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients BCSH/BSBMT/UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation Management of RSV infections in adult recipients of hematopoietic stem cell transplantation Management of respiratory viral infections in hematopoietic cell transplant recipients and patients with hematologic malignancies Fungal pneumonia in patients with hematologic malignancy and hematopoietic stem cell transplantation Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Neuromuscular blockers in early acute respiratory distress syndrome Prone positioning in severe acute respiratory distress syndrome Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure The Intensive Care Medicine research agenda on critically ill oncology and hematology patients Failure of noninvasive ventilation for de novo acute hypoxemic respiratory failure: role of tidal volume Noninvasive ventilation during acute respiratory distress syndrome in patients with cancer: trends in use and outcome Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: a randomized clinical trial Acute respiratory failure in patients with hematological malignancies: outcomes according to initial ventilation strategy. Refinement of transplant techniques over the last 2 decades has dramatically decreased transplant-related mortality, but approximately 15% of HSCT patients require critical care keywords: acute; allogeneic; cell; failure; gvhd; hematopoietic; hsct; mortality; patients; stem; syndrome; transplant; transplantation cache: cord-017302-xez0zso3.txt plain text: cord-017302-xez0zso3.txt item: #360 of 2876 id: cord-017309-pt27efu1 author: Gupta, G. S. title: Selectins and Associated Adhesion Proteins in Inflammatory disorders date: 2012-03-20 words: 25465 flesch: 31 summary: Effect of extracellular pH Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis Lp95, a novel leptospiral protein that binds extracellular matrix components and activates E-selectin on endothelial cells Genetic polymorphisms in cytokine and adhesion molecule genes in coronary artery disease E-selectin regulates gene expression in metastatic colorectal carcinoma cells and enhances HMGB1 release Regulation of gene expression by a-tocopherol E-selectin, and P-selectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kB pathway Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection Selectin inhibitors: a patent review The involvement of the sLe-a selectin ligand in the extravasation of human colorectal carcinoma cells Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury Plasma indices of endothelial and platelet activation in Rheumatoid Disease: relationship to cardiovascular co-morbidity Soluble intercellular adhesion molecule-1 and E-selectin in patients with asthma exacerbation Selectins and monocyte chemotactic peptide as the markers of atherosclerosis activity Soluble adhesion molecules in pediatric rheumatic diseases Impact of prolonged cyclooxygenase-2 inhibition on inflammatory markers and endothelial function in patients with ischemic heart disease and raised Creactive protein: a randomized placebo-controlled study Antimetastatic activities of modified heparins: selectin inhibition by heparin attenuates metastasis Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase TNF-a blockade induces a reversible but transient effect on endothelial dysfunction in patients with long-standing severe rheumatoid arthritis Transcriptional arrest of the human E-selectin gene Expression of E-selectin and its transcripts during intestinal ischemia-reperfusion injury in pigs The antitumor activity of an anti-CD54 antibody in SCID mice xenografted with human breast, prostate, non-small cell lung, and pancreatic tumor cell lines Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress Invasive amebiasis: A microcirculatory disorder? P-selectin knockout mice have improved outcomes with both warm ischemia and small bowel transplantation Soluble E-selectin in children and adolescents with type 1 diabetes Blocking E-selectin inhibits ischaemiareperfusion-induced neutrophil recruitment to the murine testis Increased platelet CD63 and Pselectin expression persist in atherosclerotic ischemic stroke Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro Increased plasma levels of soluble P-selectin in rheumatic mitral stenosis The common variants of E-selectin gene in Graves' disease Aspergillus fumigatus stimulates leukocyte adhesion molecules and cytokine production by endothelial cells in vitro and during invasive pulmonary disease Pathogenic aspects of pulmonary complications in acute pancreatitis patients Effect of rosiglitazone treatment on circulating vascular and inflammatory markers in insulin-resistant subjects Changes in Pselectin expression on cardiac microvessels in blood-perfused rat hearts subjected to ischemia-reperfusion Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells Successful treatment of rheumatoid arthritis is associated with a reduction in serum sEselectin and thrombomodulin level Cytoadherence characteristics to endothelial receptors ICAM-1 and CD36 of Plasmodium falciparum populations from severe and uncomplicated malaria cases P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice Circulating E-selectin and tumor necrosis factor-alpha in extraarticular involvement and joint disease activity in rheumatoid arthritis Protein biochip array of adhesion molecule expression in peripheral blood of patients with nasal polyposis Serum P-selectin, soluble vascular cell adhesion molecule-I (s-VCAM-I) and soluble intercellular adhesion molecule-I (s-ICAM-I) levels in bladder carcinoma patients with different stages Autoantibodies and other serological markers in rheumatoid arthritis: predictors of disease activity? Phenyl methimazole inhibits TNF-a-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumor necrosis Evaluation of sE-Selectin and sICAM-1 as parameters for renal function ICAM1 R241 is not associated with celiac disease in the Spanish population Comparative study of adhesion molecule expression in nodular lesions of Behçet syndrome and other forms of panniculitis Evidence of increased inflammation and microcirculatory abnormalities in patients with type 1 diabetes and their role in microvascular complications Circulating levels of soluble adhesion molecules in patients with ANCA-associated vasculitis Plasma cytokine and P-selectin levels in advanced malignancy: prognostic value and impact of low-molecular weight heparin administration Circulating adhesion molecules and purine nucleotides during kidney allograft reperfusion P-selectin-targeting of the fibrin selective thrombolytic Desmodus rotundus salivary plasminogen activator alpha1 E-and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study Does colorectal cancer clinical advancement affect adhesion molecules (sP-selectin, sE-selectin and ICAM-1) concentration? Soluble P-selectin concentration in patients with colorectal cancer Serum levels of soluble E-selectin are associated with the clinical course of metastatic disease in patients with liver metastases from breast cancer Markers for endothelial activation during open heart surgery Cell adhesion molecules-update Expression of selected adhesion molecules in dermatitis herpetiformis and bullous pemphigoid Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells and endothelial cells during endotoxemia Serum concentrations of sICAM-1, sE-, sP-and sL-selectins in patients with Schistosoma mansoni infection and association with disease severity Biochemical markers of endothelial activation in primary hyperparathyroidism Markers of low-grade inflammation and soluble cell adhesion molecules in Chinese patients with coronary artery disease Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians Selectins in the HIT syndrome: pathophysiologic role and therapeutic modulation Disruption of Pselectin signaling modulates cell trafficking and results in improved outcomes after mouse warm intestinal ischemia and reperfusion injury CD62 blockade with P-Selectin glycoprotein ligand-immunoglobulin fusion protein reduces ischemia-reperfusion injury after rat intestinal transplantation Independent pathways of P-selectin and complement-mediated renal ischemia/reperfusion injury IFN-g inhibits double-stranded RNAinduced E-selectin expression in human endothelial cells Candidate gene analysis of selectin cluster in patients with multiple sclerosis Enhanced expression of E-selectin on the vascular endothelium of peripheral nerve in critically ill patients with neuromuscular disorders A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya ICAM-1-dependent pathways regulate colonic eosinophilic inflammation Role of inflammation in diabetic nephropathy Circulating endothelial cells and rheumatoid arthritis: relationship with plasma markers of endothelial damage/dysfunction Variation in the ICAM1 gene is not associated with severe malaria phenotypes Interactions of the gastrotropic bacterium Helicobacter pylori with the leukocyteendothelium adhesion molecules, the selectins-A preliminary report Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells P-Selectin-mediated acute inflammation can be blocked by chemically modified heparin, RO-heparin Selectin blockade plus therapy with low-dose sirolimus and cyclosporin A prevent brain death-induced renal allograft dysfunction Microvascular endothelial cells from E-selectin-deficient mice form tubes in vitro Ser128Arg gene polymorphism for E-selectin and severity of atherosclerotic arterial disease Retinoic acid inhibits the regulated expression of vascular cell adhesion molecule-1 by cultured dermal microvascular endothelial cells Leukocyte and endothelial cell adhesion molecules in inflammation focusing on inflammatory heart disease Putative outer membrane proteins of Leptospira interrogans stimulate human umbilical vein endothelial cells (HUVECS) and express during infection Expression of adhesion molecules in lungs of mice infected with Paracoccidioides brasiliensis conidia Circulating P-,L-and E-selectins in pseudoxanthoma elasticum patients Selectins and selectin ligands in extravasation of cancer cells and organ selectivity of metastasis Angiotensin receptor blockade decreases markers of vascular inflammation Implication of adhesion molecules in inflammation of the common bile duct in patients with secondary cholangitis due to biliary obstruction Serum levels of intercellular adhesion molecule ICAM-1 and E-selectin in advanced stage non-small cell lung cancer E-selectin genetic variation as a susceptibility factor for ischemic stroke E-selectin gene induction by ionizing radiation is independent of cytokine induction Nuclear factor kappaB dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium Strategies to reduce oxidative stress in cardiovascular disease Variant isoforms of CD44 are P-and L-selectin ligands on colon carcinoma cells Soluble cell adhesion molecules in gingival crevicular fluid in periodontal health and disease E-selectin gene S128R polymorphism is associated with poor prognosis in patients with stage II or III colorectal cancer Role of adhesion molecules in the induction of restenosis after angioplasty in the lower limb The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction Tumor necrosis factor-alpha upregulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways In vivo imaging of cutaneous T-cell lymphoma migration to the skin Injury of the blood brain barrier and up-regulation of ICAM-1 in polymicrobial sepsis Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae Pravastatin limits radiation-induced vascular dysfunction in the skin Thrombosis and atherosclerosis Endothelial microparticles as markers of endothelial dysfunction E-selectin and Lselectin polymorphisms in patients with periodontitis Endothelial activation and systemic inflammation in obese asthmatic children Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosisassociated pulmonary arterial hypertension Significance of endothelial molecular markers in the evaluation of the severity of acute pancreatitis Serum levels of P-selectin in men with high-functioning autism The various effects of four H1-antagonists on serum substance P levels in patients with atopic dermatitis Immunohistochemistry, glycosylation and immunosuppression of glycodelin in human ovarian cancer The role of the platelet in the pathogenesis of atherothrombosis Differential metastasis inhibition by clinically relevant levels of heparins-correlation with selectin inhibition, not antithrombotic activity Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. keywords: acid; activation; activity; adhesion; adhesion molecules; atherosclerosis; blood; cancer; cell adhesion; cells; chronic; disease; effect; endothelial; et al; expression; factor; gene; heparin; icam-1; increase; inflammation; inhibition; injury; interactions; leukocyte; levels; ligand; liver; markers; metastasis; mice; molecules; patients; plasma; platelet; polymorphism; protein; risk; role; selectin; serum; sle; surface; tnf; tumor; type; vascular cache: cord-017309-pt27efu1.txt plain text: cord-017309-pt27efu1.txt item: #361 of 2876 id: cord-017324-l3d3t4wh author: DjukanoviĆ, Ljubica title: Balkan nephropathy date: 2008 words: 6844 flesch: 37 summary: The prevalence of Balkan endemic nephropathy has not changed since 1971 in the Kolubara region in Serbia Epidemiology and treatment of renal pelvic and ureeral tumours Tumors of the upper urothelium and endemic nephropathy Decreasing incidence of urothelial cancer in a Balkan endemic nephropathy region in Serbia. Recherches cliniques et étiologique Papillary transitional cell tumours, Balkan nephropathy, and beta2-microglobulin Cytogenetic studies in Balkan endemic nephropathy Spontaneous and induced chromosome aberrations in Balkan endemic nephropathy Genetic predisposition to Balkan endemic nephropathy Etiology of Balkan endemic nephropathy: a multifactorial disease? Induction of characteristic chromosomal aberrations, particularly X-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy The inheritance of liability of Balkan nephropathy The monofactorial model for inheritance of liability to disease and its implications for relatives at risk Particules virales dans le rein de la nephropathie endemique Balcanique Endemic Balkan nephropathy, a slow virus disease? keywords: balkan; balkan nephropathy; changes; chronic; criteria; diagnosis; disease; endemic; kidneys; nephropathy; non; patients; renal; studies; tumors cache: cord-017324-l3d3t4wh.txt plain text: cord-017324-l3d3t4wh.txt item: #362 of 2876 id: cord-017337-vq3edhxn author: Vincent, Jean-Louis title: PIRO: The Key to Success? date: 2009 words: 3811 flesch: 40 summary: Systemic infl ammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients The Italian SEPSIS study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock Dear Sirs, I'm sorry to say that I don't like you SCCM/ESICM/ACCP/ATS/SIS International Sepsis Defi nitions Conference Measures, markers, and mediators: toward a staging system for clinical sepsis. In the Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial [20] , patients with urinary tract infections as a source of severe sepsis had a 28-day all-cause mortality of 21% compared with patients with a pulmonary source of sepsis who had a mortality rate of 34% (p < .01). keywords: dysfunction; infection; mortality; organ; patients; piro; response; sepsis; system cache: cord-017337-vq3edhxn.txt plain text: cord-017337-vq3edhxn.txt item: #363 of 2876 id: cord-017350-rwqaw5ii author: Venet, F. title: Monitoring Immune Dysfunction in Septic Patients: Toward Tailored Immunotherapy date: 2010-03-10 words: 3967 flesch: 33 summary: A randomized, double-blind, placebo-controlled trial A randomized phase II trial of granulocyte-macrophage colony-stimulating factor therapy in severe sepsis with respiratory dysfunction Effect of granulocyte-monocyte colony-stimulating factor therapy on leukocyte function and clearance of serious infection in nonneutropenic patients Regulatory T cell populations in sepsis and trauma The effects of injury on the adaptive immune response Negative signaling contributes to T-cell anergy in trauma patients Both percentage of gammadelta T lymphocytes and CD3 expression are reduced during septic shock Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis Depletion of dendritic cells, but not macrophages, in patients with sepsis Apoptotic cell death in patients with sepsis, shock and multiple organ dysfunction Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: a cohort study in septic shock patients In vitro and in silico analysis of annexin V binding to lymphocytes as a biomarker in emergency department sepsis studies IL-7 and IL-15: therapeutic cytokines for immunodeficiency Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsis Improved survival in experimental sepsis with an orally administered inhibitor of apoptosis An increase in the percentage of Treg has been described in septic shock patients [22] . keywords: apoptosis; cells; expression; patients; response; sepsis; shock cache: cord-017350-rwqaw5ii.txt plain text: cord-017350-rwqaw5ii.txt item: #364 of 2876 id: cord-017374-clctlm5l author: Diamantaki, Eleni title: Acute Respiratory Failure Before ICU Admission: A Practical Approach date: 2017-06-28 words: 4306 flesch: 26 summary: The prognosis of acute respiratory failure in critically ill cancer patients Prognostic factors in critically ill cancer patients admitted to the intensive care unit Diagnostic strategy in cancer patients with acute respiratory failure Diagnostic strategy for hematology and oncology patients with acute respiratory failure: randomized controlled trial Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data CT signs and patterns of lung disease Role of HRCT in detection and characterization of pulmonary abnormalities in patients with febrile neutropenia Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol Suppressed neutrophil function as a risk factor for severe infection after cytotoxic chemotherapy in patients with acute nonlymphocytic leukemia Lung infections after cancer chemotherapy Respiratory tract infections in the immunocompromised Utility of fiberoptic bronchoscopy in neutropenic patients admitted to the intensive care unit with pulmonary infiltrates The clinical spectrum of pulmonary aspergillosis Pulmonary aspergillosis Consensus guidelines for diagnosis, prophylaxis and management of Pneumocystis jirovecii pneumonia in patients with haematological and solid malignancies Evaluation of PCR in bronchoalveolar lavage fluid for diagnosis of Pneumocystis jirovecii pneumonia: a bivariate meta-analysis and systematic review PCR diagnosis of Pneumocystis pneumonia: a bivariate meta-analysis Cytomegalovirus diseases after hematopoietic stem cell transplantation: a mini-review Diagnosis and treatment approaches to CMV infections in adult patients Acute respiratory distress syndrome: the Berlin definition Acute respiratory distress syndrome in patients with malignancies The Acute Respiratory Distress Syndrome Network. key: cord-017374-clctlm5l authors: Diamantaki, Eleni; Proklou, Athanasia; Pediaditis, Emmanouil; Amargianitakis, Vasilis; Kondili, Eumorfia title: Acute Respiratory Failure Before ICU Admission: A Practical Approach date: 2017-06-28 journal: Mechanical Ventilation in Critically Ill Cancer Patients DOI: 10.1007/978-3-319-49256-8_10 sha: doc_id: 17374 cord_uid: clctlm5l Acute respiratory failure (ARF) is a common and life-threatening event in cancer patients. keywords: acute; arf; cancer; cause; diagnosis; lung; patients; pneumonia; pulmonary cache: cord-017374-clctlm5l.txt plain text: cord-017374-clctlm5l.txt item: #365 of 2876 id: cord-017392-ja9b5vy9 author: Waterer, G. W. title: Adjunctive and Supportive Measures for Community-Acquired Pneumonia date: 2010-05-20 words: 4464 flesch: 31 summary: While some causative microorganisms, such as Pseudomonas, and some strains of common causative microorganisms appear to be more virulent, the majority of CAP patients who die are infected with organisms sensitive to commonly prescribed antibiotics. The best evidence of benefit for corticosteroids comes from studies in specific, narrowly defined groups of CAP patients caused by less common agents. keywords: cap; effect; failure; mortality; oxygenation; patients; pneumonia; study; therapy cache: cord-017392-ja9b5vy9.txt plain text: cord-017392-ja9b5vy9.txt item: #366 of 2876 id: cord-017393-kx8kmdej author: Herbers, Alexandra title: Acute Myelogenous Leukemia and Febrile Neutropenia date: 2009-08-31 words: 13297 flesch: 27 summary: A review of 55 cases Cytosine arabinoside as a major risk factor for Streptococcus viridans septicemia following bone marrow transplantation: a 5-year prospective study Bacteremia due to viridans streptococci in neutropenic patients: a review Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview Clostridium septicum sepsis and neutropenic enterocolitis in a patient treated with intensive chemotherapy for acute myeloid leukemia Clostridium septicum septicemia with identical metastatic myonecroses in a granulocytopenic patient Incidence and significance of Clostridium difficile in hospitalized cancer patients Clostridium difficile in haematological malignancy Epidemiology and prevention of Clostridium difficile infection in a leukemia unit The epidemiology of Clostridium difficile with use of a typing scheme: nosocomial acquisition and cross-infection among immunocompromised patients Clostridium difficile infection in patients with neutropenia Toxoplasmosis of the central nervous system Hyperinfection syndrome with strongyloidiasis New b-lactams: new problems for the internist Bacteremia due to Stenotrophomonas (Xanthomonas) maltophilia: a prospective multicenter study of 91 episodes Opportunistic mycoses in the immunocompromised host: experience at a cancer center and review Cutaneous lesions in disseminated candidiasis mimicking ecthyma gangrenosum Pseudomonas bacteremia: retrospective analysis of 410 episodes Intradermal bullous dermatitis due candidiasis in an immunocompromised patient Atypical bullous pyoderma gangrenosum associated with myeloid malignancies Sweet's syndrome and malignancy Concomitant illness in patients treated for Hodgkin's disease Disseminated varicella at autopsy in children with cancer Varicella zoster virus infections: biology, natural history, treatment and prevention Ultrasound screening for internal jugular vein thrombosis aids the detection of central venous catheter-related infections in patients with haemato-oncological diseases: a prospective observational study Periodontal infections in patients with acute nonlymphocytic leukemia: prevalence of acute exacerbations Oral infections and fever in immunocompromised patients with haematologic malignancies Anaerobic bacteremia in a cancer center Infections with herpes simplex viruses Respiratory disease in the immunosuppressed patient Potential sites of infection that develop in febrile neutropenic patients Pneumocystis carinii pneumonia in cancer patients Successful intermittent chemoprophylaxis for Pneumocystis carinii pneumonitis Respiratory syncytial virus pneumonia in hospitalized adult patients with leukemia Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Pseudomonas septicemia: incidence, epidemiology, prevention and therapy in patients with advanced cancer Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis in the influence of antibiotic treatment. A European Organization for Research and treatment of Cancer-International Antimicrobial Therapy Group Study of secondary infections in febrile, neutropenic patients with cancer Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia Empiric antifungal therapy in febrile neutropenic patients International conference for the development of a consensus on the management and prevention of severe candidal infections Micafungin Invasive Candidiasis Working Group et al (2007) Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial Voriconazole versus a regimen of amphotericin B followed by fluconazole for candidaemia in non-neutropenic patients: a randomised non-inferiority trial Echinocandins -first-choice or first-line therapy for invasive candidiasis? Detection of circulating candida enolase by immunoassay in patients with cancer and invasive candidiasis Sandwich enzyme-linked immunosorbent assay compared with Pastorex latex agglutination test for diagnosing invasive aspergillosis in immunocompromised patients Fungal infections in recipients of hematopoietic stem cell transplants: results of the SEIFEM B-2004 study -Sorveglianza Epidemiologica Infezioni Fungine nelle Empatie Maligne Clinical evaluation and reproducibility of the Pastorex Aspergillus antigen latex agglutination test for diagnosing invasive aspergillosis Galactomannan and computed tomography-based preemptive antifungal therapy in neutropenic patients at risk of invasive fungal infection: a prospective feasibility study Between over-and undertreatment of invasive fungal disease Presumptive treatment strategy for aspergillosis in allogeneic haematopoietic stem cell transplant recipients Imaging findings in acute invasive pulmonary aspergillosis: clinical significance of the halo sign Invasive pulmonary aspergillosis in acute leukemia: characteristics findings on CT, the CT halo sign, and the role of CT in early diagnosis Improved management of invasive pulmonary Aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients Zygomycosis in a tertiarycare cancer center in the era of Aspergillus-active antifungal therapy: a casecontrol observational study of 27 recent cases Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia AmBiLoad keywords: acute; agents; antibiotic; antifungal; cancer; cases; fever; gram; infection; leukemia; negative; neutropenic; patients; pulmonary; regimen; results; risk; therapy; treatment; use cache: cord-017393-kx8kmdej.txt plain text: cord-017393-kx8kmdej.txt item: #367 of 2876 id: cord-017420-tjwxec77 author: Stephens, R. Scott title: Neutropenic Fever in the Intensive Care Unit date: 2019-07-09 words: 5866 flesch: 29 summary: Bacteremia is documented in up to 25% of neutropenic fever patients [28] . The signs, symptoms and helpseeking experiences of neutropenic sepsis patients before they reach hospital: a qualitative study Risk Stratification of Sepsis, C. Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients Bronchoalveolar lavage during neutropenic episodes: diagnostic yield and cellular pattern Role of circulating lymphocytes in patients with sepsis Thrombocytopenia impairs host defense in gramnegative pneumonia-derived sepsis in mice Meta-analysis of randomized controlled trials of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor after autologous and allogeneic stem cell transplantation Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients? keywords: acute; antibiotic; failure; fever; infections; mortality; neutropenic; patients; risk; sepsis; therapy; use cache: cord-017420-tjwxec77.txt plain text: cord-017420-tjwxec77.txt item: #368 of 2876 id: cord-017461-xw02c7u5 author: Kauffman, Carol A. title: Fungal Infections date: 2009-02-02 words: 5448 flesch: 35 summary: Factors that predispose older patients to the development of oropharyngeal candidiasis include xerostomia, broad-spectrum antibiotics, inhaled corticosteroids, and dentures (1) . In older patients who have cryptococcal meningitis, mortality appears to be increased (7) . keywords: adults; aspergillosis; candida; coccidioidomycosis; histoplasmosis; infection; patients; pulmonary; risk; species; therapy cache: cord-017461-xw02c7u5.txt plain text: cord-017461-xw02c7u5.txt item: #369 of 2876 id: cord-017489-ftz9190a author: Richards, Guy A. title: Viruses in the Intensive Care Unit (ICU) date: 2005 words: 5796 flesch: 37 summary: -2 % from 15-30% if initiated within the first 8 days of illness (12) and is also possibly of value in Lassa virus infection (13). Porterfield JS Clinical Practice and Public Health Control Virus induced endothelial permeability triggered by affected macrophages Hemostasis and the complement system in Argentine hemorrhagic fever Cardiovascular and pulmonary responses to Pichinde virus infection in strain 13 guinea pigs A nosocomial outbreak of Crimean-Congo hemorrhagic fever at Tyberberg Hospital (part II). keywords: cytomegalovirus; days; disease; fever; hepatitis; infection; mortality; patients; pneumonia; therapy; treatment; varicella; viral; virus cache: cord-017489-ftz9190a.txt plain text: cord-017489-ftz9190a.txt item: #370 of 2876 id: cord-017516-qbksb83c author: Si, Yain-Whar title: Hidden Cluster Detection for Infectious Disease Control and Quarantine Management date: 2009-09-30 words: 3359 flesch: 44 summary: We apply information visualization and hidden cluster detection for finding cliques of potentially infected people during incubation. Given this background, this research aims to develop a decision support system which can be used to locate the source of an outbreak by mining clusters and communities from the patients' past activities (testimonies) using techniques from infectious disease control, information visualization, and database management systems. keywords: disease; figure; infection; information; outbreak; patients; system cache: cord-017516-qbksb83c.txt plain text: cord-017516-qbksb83c.txt item: #371 of 2876 id: cord-017518-u2gsa4lg author: Divatia, J. V. title: Nosocomial Infections and Ventilator-Associated Pneumonia in Cancer Patients date: 2019-07-09 words: 8769 flesch: 28 summary: The impact of hospitalacquired infections with multidrug-resistant bacteria in an oncology intensive care unit Hospital-acquired infections at an oncological intensive care cancer unit: differences between solid and hematological cancer patients Ventilator-associated pneumonia (VAP) -early and late-onset differences Evaluation of the 2016 Infectious Diseases Society of America/American Thoracic Society guideline criteria for risk of multidrug-resistant pathogens in patients with hospital-acquired and ventilator-associated pneumonia in the ICU Benchmarking local healthcare-associated infections: available benchmarks and interpretation challenges CDC definitions for nosocomial infections The epidemiology of nonventilator hospital-acquired pneumonia in the United States Microbial profile of early and late onset ventilator associated pneumonia in the intensive care unit of a tertiary care hospital in Bangalore, India Colistin for lung infection: an update Management of nosocomial pneumonia on a medical ward: a comparative study of outcomes and costs of invasive procedures Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the Infectious Diseases Society of America Ventilator associated pneumonia Respective impact of implementation of prevention strategies, colonization with multiresistant bacteria and antimicrobial use on the risk of early-and late-onset VAP: an analysis of the OUTCOMEREA network Institute for healthcare improvement: how-to guide: prevent ventilator-associated pneumonia Institute for Healthcare Improvement: Evidence-Based Care Bundles n.d Institute For Healthcare Improvement, I. Institute for healthcare improvement: how-to guide: prevent ventilator-Associated pneumonia Defining antibiotic dosing in lung infections Trends in antibiotic use and nosocomial pathogens in hospitalized veterans with pneumonia at 128 medical centers Empirical antibiotic therapy for ventilator-associated pneumonia Ventilator-associated pneumonia in the ICU Management of Adults with hospitalacquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society Nosocomial infections and their control strategies Nosocomial infections: epidemiology, prevention, control and surveillance Severe sepsis bundles Prevalence of and risk factors for hospital-acquired infections in Slovenia-results of the first national survey The prevalence of and risk factors for healthcare-associated infections in Slovenia: results of the second national survey. Nosocomial infections or hospital-acquired infections (HAIs) are defined by the Centers for Disease Control and Prevention (CDC) as those infections that were not present in carrier state or incubating state at the time of admission and manifest 48 h after hospital admission [24] . keywords: antibiotic; care; clinical; control; days; guidelines; hospital; infections; patients; pneumonia; rates; risk; tract; treatment; use; vap; ventilator cache: cord-017518-u2gsa4lg.txt plain text: cord-017518-u2gsa4lg.txt item: #372 of 2876 id: cord-017531-fm8gl5b3 author: Andersen, Bjørg Marit title: Scenarios: Serious, Infectious Diseases date: 2018-09-25 words: 3606 flesch: 49 summary: lessons learned from the 2004 tsunami for hospital infection control In: Handbook in hygiene and infection control for hospitals. All transport of infectious patients from the place of arrival to the hospital should take place in ambulances using the same infection control regime as for the individual infectious disease (contact infection, airborne infection, strict isolation); see isolation regimes; Chaps. keywords: bacteria; contacts; control; disease; hospital; infection; isolation; patient; use cache: cord-017531-fm8gl5b3.txt plain text: cord-017531-fm8gl5b3.txt item: #373 of 2876 id: cord-017534-0ai8chbu author: Andersen, Bjørg Marit title: Background Information: Isolation Routines date: 2018-09-25 words: 9642 flesch: 49 summary: Cleaning and disinfection of rooms, surfaces and equipment between infection susceptible patients must be extra careful since many-at the same time-have serious infections, including resistant bacteria. The invisible agent does not call on attention before the infection; clinical disease, hospital infection or nosocomial infection is a factum that can be registered [23, 28, 29, 35–37]. keywords: air; category; contact; control; disinfection; equipment; healthcare; hospital; infection; isolates; isolation; norway; outbreak; patients; risk; room; spread; transmission cache: cord-017534-0ai8chbu.txt plain text: cord-017534-0ai8chbu.txt item: #374 of 2876 id: cord-017569-fv88n70v author: Hewlett, Angela title: Viral Hemorrhagic Fever Preparedness date: 2017-09-10 words: 11182 flesch: 39 summary: The design of a HLCC unit should serve to minimize nosocomial transmission of infectious diseases by establishing a contained clinical isolation unit capable of housing all facets of patient care. Press conferences with infectious diseases experts and others involved in patient care should be held to provide timely updates. keywords: biocontainment; care; control; disease; ebola; evd; facility; healthcare; hlcc; infection; laboratory; management; patient care; patients; ppe; risk; staff; team; unit; vhf; virus; waste cache: cord-017569-fv88n70v.txt plain text: cord-017569-fv88n70v.txt item: #375 of 2876 id: cord-017581-6lubp7io author: Glass, Daniel M. title: Respiratory Diseases of Pregnancy date: 2019-07-24 words: 2516 flesch: 38 summary: Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study Epidemiology of pregnancyassociated venous thromboembolism: a population-based study in Canada Pregnancy and the lungs Successful use of noninvasive ventilation in pregnancy Implications for the pregnant patient Mechanical ventilation during pregnancy: sedation, analgesia, and paralysis Systemic inflammatory response syndrome, organ failure, and outcome in critically ill obstetric patients treated in an icu Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic Modern use of extracorporeal life support in pregnancy and postpartum Prone positioning for ARDS following blunt chest trauma in late pregnancy How safe is the prone position in acute respiratory distress syndrome at late pregnancy Does delivery improve maternal condition in the respiratory-compromised gravida? key: cord-017581-6lubp7io authors: Glass, Daniel M.; Zehrer, Tara; Al-Khafaji, Ali title: Respiratory Diseases of Pregnancy date: 2019-07-24 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-030-26710-0_99 sha: doc_id: 17581 cord_uid: 6lubp7io Pregnant patients can suffer from the same respiratory diseases as the general population in addition to unique syndromes of pregnancy (such as pre-eclampsia and tocolytic induced pulmonary edema, and pregnancy induced cardiomyopathy). keywords: edema; patients; pregnancy; pressure; risk; use; ventilation cache: cord-017581-6lubp7io.txt plain text: cord-017581-6lubp7io.txt item: #376 of 2876 id: cord-017617-13m7pmvq author: Shah, Nirav title: Traveler to Uganda date: 2017-08-25 words: 1718 flesch: 48 summary: • Activities associated with histoplasmosis exposure include cleaning attics, barns and chicken coops, caving, construction, and demolition. Histoplasma polysaccharide antigen testing may be negative within 4 weeks of onset of infection in acute pulmonary histoplasmosis, so a repeat test may be necessary to confirm the diagnosis. keywords: diagnosis; histoplasma; histoplasmosis; patient; weeks cache: cord-017617-13m7pmvq.txt plain text: cord-017617-13m7pmvq.txt item: #377 of 2876 id: cord-017715-99ri6x0y author: Zhou, Bo-Ping title: SARS date: 2015-07-25 words: 8861 flesch: 42 summary: On March 21, 2003 , Hong Kong University fi rstly separated and cultured coronavirus from the nasopharyngeal specimen of SARS patients by Vero cells, and then several laboratories of Canada and America disease center and SARS international coordination group also cultured coronavirus. According to the report of WHO, SARS epidemics was found in total 29 The main source of infection is SARS patients, and other infectious sources such as animals need to be further consolidated. keywords: changes; chest; coronavirus; density; disease; head; lesions; lung; patients; phase; pulmonary; ray; sars; shadows; syndrome cache: cord-017715-99ri6x0y.txt plain text: cord-017715-99ri6x0y.txt item: #378 of 2876 id: cord-017772-zpf1xjqi author: Walter, James M. title: Thrombocytopenia in the Intensive Care Unit date: 2019-07-24 words: 4581 flesch: 37 summary: In general, ICU patients who develop thrombocytopenia are sicker than patients with normal platelet counts, with higher illness severity scores, more need for vasoactive infusions, and more organ dysfunction [8, 9] . On behalf of the working group on Sepsis-related problems of the European Society of Intensive Care Medicine Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study Pseudothrombocytopenia due to platelet clumping: a case report and brief review of the literature Bleeding and coagulopathies in critical care Guidelines for the use of platelet transfusions Evidence-based platelet transfusion guidelines Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies Syndromes of thrombotic microangiopathy Thrombotic thrombocytopenic purpura Thrombotic thrombocytopenic purpura The incidence of thrombotic thrombocytopenic purpurahemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015 Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. keywords: cells; count; dic; heparin; hit; patients; platelet; sepsis; thrombocytopenia cache: cord-017772-zpf1xjqi.txt plain text: cord-017772-zpf1xjqi.txt item: #379 of 2876 id: cord-017784-4r3fpmlb author: Foccillo, Giampiero title: The Infections Causing Acute Respiratory Failure in Elderly Patients date: 2019-08-06 words: 3573 flesch: 26 summary: Severe community-acquired pneumonia and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are causes of acute respiratory failure (ARF) in elderly patients. Elderly patients are more predisposed to pneumonia because of their impaired gag reflex, decreased mucociliary function, waning immunity, impaired febrile response, and chronic disease (diabetes mellitus, chronic obstructive pulmonary disease, chronic heart failure, cancer and chronic renal insufficiency). keywords: acute; disease; exacerbations; failure; patients; pneumonia; therapy cache: cord-017784-4r3fpmlb.txt plain text: cord-017784-4r3fpmlb.txt item: #380 of 2876 id: cord-017786-kfl6xt31 author: Curiel-Balsera, Emilio title: Guidelines for Health Organizations: European Perspectives and Experience in Pandemics date: 2013-05-29 words: 1649 flesch: 38 summary: Recommendations for droplets include patient isolation with protective measures for health care providers and other patients, use of double-circuit tubes and special fi lters for nonrebreathing devices, minimization of leaks, preferably fullface mask or helmet interfaces, avoidance of heated humidifi ers, and disposing of mask and tubes after use according to routine infection control procedures [ 7 ] . Nebulizer treatment should be performed in an area that is physically separated from other patients (e.g., treatment room, screened enclosure). keywords: care; failure; niv; patients; ventilation cache: cord-017786-kfl6xt31.txt plain text: cord-017786-kfl6xt31.txt item: #381 of 2876 id: cord-017799-2nvrakbs author: Patel, Zara M. title: Acute Bacterial Rhinosinusitis date: 2018-05-04 words: 4393 flesch: 38 summary: A summary for otorhinolaryngologists Sinusitis of the maxillary antrum Nosocomial sinusitis in patients in the medical intensive care unit: a prospective epidemiological study Nosocomial sinusitis Rhinovirus infections in an industrial population Characteristics of illness and antibody response Adult acute rhinosinusitis A practical guide for the diagnosis and treatment of acute sinusitis The pathogenesis of orbital complications in acute sinusitis Endoscopically directed middle meatal cultures versus maxillary sinus taps in acute bacterial maxillary rhinosinusitis: a meta-analysis A 51-year-old woman with acute onset of facial pressure, rhinorrhea, and tooth pain: review of acute rhinosinusitis Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children, aged 1 to 18 years Antibiotics for clinically diagnosed acute rhinosinusitis in adults Predicting prognosis and effect of antibiotic treatment in rhinosinusitis Effect of amoxicillin-clavulinate in clinically diagnosed acute rhinosinusitis. Most patients suffering with sinus symptoms will have a viral etiology of their inflammation [8] . keywords: abrs; acute; adults; antibiotics; days; nasal; patients; rhinosinusitis; symptoms cache: cord-017799-2nvrakbs.txt plain text: cord-017799-2nvrakbs.txt item: #382 of 2876 id: cord-017815-0t7jvvz5 author: Andersen, Bjørg Marit title: General Information date: 2018-09-25 words: 3819 flesch: 55 summary: Airborne infection isolation units: at least 10% of the bed capacity for adults and 10-15% of children in hospitals should be isolates well equipped with negative pressure, separate ventilation and private bath/disinfection room with decontaminator. 21. Handbook of hygiene and infection control in hospitals. keywords: contact; control; infection; isolates; isolation; patient; room; use cache: cord-017815-0t7jvvz5.txt plain text: cord-017815-0t7jvvz5.txt item: #383 of 2876 id: cord-017862-9fkjjmvf author: Smith, Roger P. title: Respiratory Disorders date: 2007 words: 6048 flesch: 48 summary: Future directions for research on diseases of the lung Echinacea for upper respiratory infection Cost burden of viral respiratory infections: issues for formulary decision makers Towards excellence in asthma management (TEAM): a population diseasemanagement model Forecasted state-specifi c estimates of self-reported asthma prevalence-1998 Management of acute bacterial rhinosinusitis Vitamin C for preventing and treating the common cold Anti-leukotrienes as add-on therapy to inhaled glucocorticoids in patients with asthma: systematic review of current evidence Rhinovirus respiratory infections and asthma Evaluation of echinacea for treatment of the common cold Respiratory viral infections in adults A randomized controlled trial of the effect of fl uid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections Clinical signifi cance and pathogenesis of viral respiratory infections Viral respiratory infection therapy: historical perspectives and current trials Effi cacy and safety of a fi xed combination phytomedicine in the treatment of the common cold (acute viral respiratory tract infection): results of a randomised, double blind, placebo controlled, multicentre study The diagnosis and treatment of cough Antivirals for the common cold Gastroesophageal refl ux disease-state of the art Pharmacologic management of common lower respiratory tract disorders in women The effi cacy of Echinacea compound herbal tea preparation on the severity and duration of upper respiratory and fl u symptoms: a randomized, double-blind placebo-controlled study H1-antihistamines in asthma Zinc for the common cold Beat the winter bugs. Healthy people with normal immune systems are highly susceptible to cold virus infection once the virus enters the nose. keywords: asthma; cases; cold; cough; days; diagnosis; fever; infections; infl; patients; pneumonia; respiratory; symptoms; treatment cache: cord-017862-9fkjjmvf.txt plain text: cord-017862-9fkjjmvf.txt item: #384 of 2876 id: cord-017883-6a4fkd5v author: Dutta, Ankhi title: Infection Prevention in Pediatric Oncology and Hematopoietic Stem Cell Transplant Recipients date: 2018-07-16 words: 6245 flesch: 31 summary: A pediatric pilot study on the use of ciprofloxacin prophylaxis for pediatric patients receiving delayed intensification therapy for acute lymphoblastic leukemia (ALL) showed a reduction in hospitalization, intensive care admission, and bacteremia when compared to controls [21] . Pediatric patients with mild (ANC ≥500) and brief periods of neutropenia (<7 days) are less likely to have infectious complications than those [20, 29, 30] A. Dutta and R. Flores with moderate to severe neutropenia (ANC ≤500) lasting more than 7 days. keywords: cancer; children; hsct; ifd; infection; neutropenia; patients; pediatric; pho; prophylaxis; recipients; risk; therapy; treatment cache: cord-017883-6a4fkd5v.txt plain text: cord-017883-6a4fkd5v.txt item: #385 of 2876 id: cord-017897-mbwm0ytg author: Chiumello, Davide title: The Acute Respiratory Distress Syndrome: Diagnosis and Management date: 2018-10-01 words: 4827 flesch: 28 summary: Compressive forces and computed tomography-derived positive end-expiratory pressure in acute respiratory distress syndrome Recruitment maneuvers in acute respiratory distress syndrome and during general anesthesia Effects of alveolar recruitment maneuvers on clinical outcomes in patients with acute respiratory distress syndrome: a systematic review and meta-analysis Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment Lung stress and strain during mechanical ventilation: any safe threshold? Low-dose chest computed tomography for quantitative and visual anatomical analysis in patients with acute respiratory distress syndrome Stress and strain within the lung The assessment of transpulmonary pressure in mechanically ventilated ARDS patients Lung protective ventilation strategy for the acute respiratory distress syndrome Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome Driving pressure and survival in the acute respiratory distress syndrome Balancing neuromuscular blockade versus preserved muscle activity Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study Driving pressure and intraoperative protective ventilation Neuromuscular blocking agents in patients with acute respiratory distress syndrome: a summary of the current evidence from three randomized controlled trials The prone position in ARDS patients Use of extreme position changes in acute respiratory failure Prone position in acute respiratory distress syndrome. In respiratory failure patients, lung ultrasound is characterized mainly by B-line (hyperechogenic vertical artifact line that starts from pleura) keywords: acute; ards; distress; failure; lung; patients; pressure; syndrome; ventilation cache: cord-017897-mbwm0ytg.txt plain text: cord-017897-mbwm0ytg.txt item: #386 of 2876 id: cord-017946-fa4ehlb0 author: Lawless, Ryan A. title: Adjuncts to Resuscitation date: 2018-05-26 words: 5945 flesch: 32 summary: Damage control resuscitation: the new face of damage control Damage control: collective review Damage control resuscitation: directly addressing the early coagulopathy of trauma Damage control resuscitation reduces volumes and improves survival in 390 damage control laparotomy patients Restrictive fluid resuscitation in combination with damage control resuscitation: time for adaptation The preventative treatment of wound shock General surgery Fluid resuscitation strategies: as systematic review of animal trials Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality Intraoperative hypotensive resuscitation for patients undergoing laparotomy or thoracotomy for trauma: early termination of a randomized prospective clinical trial Role of permissive hypotension, hypertonic resuscitation and the global increased permeability syndrome in patients with severe hemorrhage: adjuncts to damage control resuscitation to prevent intra-abdominal hypertension Physiology of shock Fluid therapy in hemorrhagic shock ATLS: advanced trauma life support: student course manual In vivo effect of haemodilution with saline on coagulation: a randomized controlled trial Pathophysiology and management of abdominal compartment syndrome Hyperacute abdominal compartment syndrome: an unrecognized complication of massive intraoperative resuscitation for extraabdominal injuries The cellular, metabolic, and systemic consequences of aggressive fluid resuscitation strategies Early predictors of massive transfusion in combat casualties Coagulopathy: its pathophysiology and treatment in the injured patient Secondary abdominal compartment syndrome is an elusive early complication of traumatic shock resuscitation Coagulopathy in the trauma patient Effect of blood pressure on hemorrhage volume and survival in nearfatal hemorrhage model incorporating a vascular injury Improved outcome with hypotensive resuscitation of uncontrolled hemorrhagic shock in a swine model Central and regional hemodynamics during crystalloid fluid therapy after uncontrolled intra-abdominal bleeding The detrimental effects of intravenous crystalloid after aortotomy in swine Immediate versus delayed resuscitation for hypotensive trauma patients with penetrating torso injuries Improved outcome with fluid restriction in treatment of uncontrolled hemorrhagic shock A controlled resuscitation strategy is feasible and safe in hypotensive trauma patients: results of a prospective randomized pilot trial Eight years if experience with massive blood transfusion A massive transfusion protocol to decrease blood component use and costs Damage control hematology: impact of a defined exsanguination protocol on mortality and blood utilization Prediction of massive transfusion Transfusion of plasma, platelets, and red blood cells in a 1:1:1 versus 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial Creation, implementation, and maturation of a massive transfusion protocol for exsanguinating trauma patient Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction Damage control resuscitation in patients with severe traumatic hemorrhage: a practice management guideline from the Eastern Association for the Surgery of Trauma An emergency department thawed plasma protocol for severely injured patients American College of Surgeons Committee on Trauma (nd) Room for (performance) improvement: provider-related factors associated with poor outcomes in massive transfusion Compliance with massive transfusion protocol (MTP) impacts patient outcome Multicenter validation of a simplified score to predict massive transfusion Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption Transfusion therapy in hemorrhagic shock Every minute counts: time to delivery of initial massive transfusion cooler and its impact on mortality Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant hemorrhage (CRASH-2): a randomized, placebo-controlled trial Cost effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial Tranexamic acid in trauma: how should we use it? Time course of haemostatic effects of fibrinogen concentrate administration Mechanisms of hydroxyethyl starchinduced dilutional coagulopathy Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate Administration of fibrinogen concentrate in exsanguinating trauma patients is associated with improved survival at 6 hours but not at discharge Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury Cryoprecipitate use in the PROMMTT study A window of opportunity: the aggressive use of plasma in early resuscitation Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study Prothrombin complex concentrate in trauma patients Experience with prothrombin complex for the emergent reversal of anticoagulation in rural geriatric trauma patients Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw Damage control resuscitation The use of recombinant activated factor VII in platelet-associated bleeding Use of recombinant factor VIIa for adjunctive hemorrhage control in trauma and surgical patients Recombinant factor VIIa for hemorrhage control: early experience in critically ill trauma patients Recombinant factor VIIa for the treatment of severe postoperative and traumatic hemorrhage Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebocontrolled, double-blinded clinical trials Use of activated recombinant coagulation factor VII in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: a double-blind, randomized, placebocontrolled trial Results of the CONTROL trial: efficacy and safety of recombinant activated factor VII in the management of refractory traumatic hemorrhage Vasopressin in hemorrhagic shock: a systematic review and meta-analysis of randomized animal trials Vasopressin clearance and secretion during haemorrhage in normal dogs and in dogs with experimental diabetes insipidus Vasopressin and shock but not fluid resuscitation, enhances survival in a liver trauma model with uncontrolled and otherwise lethal hemorrhagic shock in pigs Potential benefit of vasopressin in resuscitation of hemorrhagic shock Vasopressin deficiency in the syndrome of irreversible shock Arginine vasopressin, but not epinephrine, improves survival in uncontrolled hemorrhagic shock after liver trauma in pigs Vasopressin improves survival in a porcine model of abdominal vascular injury Anti-tumor mechanisms if valproate: a novel role for an old drug Acetylation: a regulatory modification to rival phosphorylation? Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen Gene activation by histone and factor acetyltransferase Regulation of lifespan by histone deacetylase Cardiac histones are substrates of histone deacetylase activity in hemorrhagic shock and resuscitation Valproic acid prevents hemorrhage-associated lethality and affects the acetylation patterns of cardiac histones Surviving blood loss without fluid resuscitation Surviving blood loss without blood transfusion in a swine poly-trauma model A rational approach to perioperative fluid management Dynamic fluid redistribution in hyperosmolar resuscitation of hypovolemic hemorrhage Damage control immunoregulation: is there a role for low-volume hypertonic saline resuscitation in patients managed with damage control surgery? Hypertonic saline and the microcirculation Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis keywords: blood; control; damage; hemorrhage; hypertonic; mortality; patients; resuscitation; saline; shock; transfusion; trauma; use cache: cord-017946-fa4ehlb0.txt plain text: cord-017946-fa4ehlb0.txt item: #387 of 2876 id: cord-018005-53cl75gk author: Humphreys, Hilary title: Lower Respiratory Tract Infections date: 2012-08-21 words: 3865 flesch: 34 summary: Plain radiographs of adequate diagnostic quality are often dif fi cult to obtain in critical care patients and CT scanning is often required to make a radiological diagnosis which should be supplemented with microbiological samples to con fi rm the aetiology [ 30 ] . All units admitting such patients should have local protocols and training in place to offer NIV to patients presenting in respiratory failure in the context of COPD. keywords: cap; care; copd; icu; intensive; mortality; patients; pneumonia cache: cord-018005-53cl75gk.txt plain text: cord-018005-53cl75gk.txt item: #388 of 2876 id: cord-018106-5giapmcf author: Levin, Jacqueline title: Mental Health Care for Survivors and Healthcare Workers in the Aftermath of an Outbreak date: 2019-05-16 words: 4253 flesch: 33 summary: Similar findings have been reported in multiple studies indicating acute and persistently elevated stress levels as well as other emotional sequelae of healthcare workers during and after pandemic disease outbreaks [10] [11] [12] . Communication at every level should be monitored, with systems in place to bidirectionally transmit news among healthcare workers, their administration, healthcare facilities, and the government [10] . keywords: disorder; healthcare; outbreak; pandemic; patients; psychiatric; stress; symptoms; workers cache: cord-018106-5giapmcf.txt plain text: cord-018106-5giapmcf.txt item: #389 of 2876 id: cord-018110-mcw4v13c author: Arnold, Andreas title: Inner Ear date: 2010 words: 15862 flesch: 42 summary: However, recurrence rates of such hearing losses range up to 30%. For profoundly deaf children (typically those with • hearing losses greater than 100 dB) and those chil-loss, the GJB2 gene encodes for the connexin 26 molecule. keywords: aids; auditory; canal; cases; cochlear; days; diagnosis; disease; fig; frequency; hearing; hearing loss; noise; patients; sound; speech; symptoms; system; therapy; tinnitus; treatment; vertigo; vestibular; window cache: cord-018110-mcw4v13c.txt plain text: cord-018110-mcw4v13c.txt item: #390 of 2876 id: cord-018182-lleti89n author: Kassutto, Stacey M. title: Care of the Surgical ICU Patient with Chronic Obstructive Pulmonary Disease and Pulmonary Hypertension date: 2016-10-09 words: 6227 flesch: 29 summary: These exacerbations carry a significant risk to patients, with 10 % in-hospital mortality and 1-year and 2-year all-cause mortality rates of 43 % and 49 %, respectively, in patients with hypercapnic exacerbations [3]. Given that patients transferred to the ICU with AECOPD are at high risk for complications and adverse outcomes, early diagnosis and management are critical to improve patient outcomes and survival in this population. keywords: acute; aecopd; chronic; disease; exacerbations; failure; icu; management; patients; pressure; ventilation cache: cord-018182-lleti89n.txt plain text: cord-018182-lleti89n.txt item: #391 of 2876 id: cord-018209-v2crgj5w author: Pastores, Stephen M. title: What Has Been Learned from Postmortem Studies? date: 2010-08-19 words: 5277 flesch: 24 summary: DAD has been reported at autopsy in 63.5% of patients with treated leukemia and lymphoma and close to 50% among HSCT patients [7, 8] . Infections as the cause of DAD are identified on autopsy in only a third of HSCT patients, while approximately 20% have DAH. keywords: alveolar; autopsy; diagnosis; discrepancies; hemorrhage; hsct; infections; malignancies; patients; pulmonary; recipients; transplantation cache: cord-018209-v2crgj5w.txt plain text: cord-018209-v2crgj5w.txt item: #392 of 2876 id: cord-018225-dozmy3lb author: Hawker, Felicity H. title: The liver in critical illness date: 2008 words: 6821 flesch: 42 summary: The seminal paper by O'Grady and the group from King's College Hospital, London, develops criteria for liver transplantation in acute liver failure. This paper was the first large case study to document the feasibility and success of liver transplantation for acute liver failure. keywords: acetylcysteine; acute; failure; function; hepatitis; liver; patients; study; time; transplantation cache: cord-018225-dozmy3lb.txt plain text: cord-018225-dozmy3lb.txt item: #393 of 2876 id: cord-018243-hyvu9nuq author: Salman, Huda title: Fibrosing Alveolitis in Hematologic Malignancy Patients Undergoing Hematopoietic Cell Transplantation date: 2010-08-19 words: 6992 flesch: 27 summary: Hence, while opportunistic infections still contribute to chronic lung disease, late sequelae resulting from antineoplastic therapy have been identified and reported. Chronic pulmonary disease following allogeneic HSCT likely involves an initial insult to lung parenchyma followed by an ongoing inflammatory process involving the interplay between recruited donor-derived immune cells and the resident cells of the pulmonary vascular endothelium and interstitium. keywords: acute; chronic; disease; drug; fibrosis; gvhd; hsct; injury; lung; patients; pulmonary; radiation; therapy; toxicity; transplantation cache: cord-018243-hyvu9nuq.txt plain text: cord-018243-hyvu9nuq.txt item: #394 of 2876 id: cord-018303-dvuwhpyq author: Garibaldi, Brian T. title: Aeromedical Evacuation of Patients with Contagious Infections date: 2019-02-27 words: 9016 flesch: 45 summary: While most studies of aircraft cabin air quality have focused on tobacco by-products and other chemical contaminants, few have addressed the ecology of airborne microbes. [22] Disinfection of the aircraft is an important element to consider in the AE of infectious disease patients. keywords: air; aircraft; cabin; crew; diseases; ebola; fever; flight; health; infection; influenza; military; patients; risk; system; transmission; transport; travel; tuberculosis; ventilation cache: cord-018303-dvuwhpyq.txt plain text: cord-018303-dvuwhpyq.txt item: #395 of 2876 id: cord-018318-vzzrsqsn author: Naidu, C. Sudeep title: Postoperative Liver Failure date: 2017-02-08 words: 9074 flesch: 38 summary: Liver stiffness correlated well with ICGR15 in liver resection patients, and predicted early postoperative complications and was recommended, to provide 'better prognostic information for patients undergoing resection.' key: cord-018318-vzzrsqsn authors: Naidu, C. Sudeep; Sarin, Arti title: Postoperative Liver Failure date: 2017-02-08 journal: GI Surgery Annual DOI: 10.1007/978-981-10-2678-2_3 sha: doc_id: 18318 cord_uid: vzzrsqsn Technical innovations in surgical techniques, anaesthesia, critical care and a spatial understanding of the intra-hepatic anatomy of the liver, have led to an increasing number of liver resections being performed all over the world. keywords: cirrhosis; clamping; disease; failure; flr; function; hepatectomy; hepatic; infl; liver; mortality; patients; plf; resection; risk; sepsis; surgery cache: cord-018318-vzzrsqsn.txt plain text: cord-018318-vzzrsqsn.txt item: #396 of 2876 id: cord-018363-qr1pk78u author: Casey, Ashley title: Consultative and Comanagement date: 2015-10-10 words: 19245 flesch: 58 summary: Answer: C Patients who have undergone signifi cant bowel resection should receive acid suppression in the postoperative period with a proton pump inhibitor. Answer: D Patients with -RA presenting for TKR represent those patients who have failed medical management and are a high-risk group for cervical spine involvement. keywords: answer; benefi; blood; bowel; cancer; daily; days; disease; dose; examination; following; heart; history; hospital; mortality; oral; pain; patient; rate; risk; surgery; syndrome; therapy; treatment; tube; warfarin; year cache: cord-018363-qr1pk78u.txt plain text: cord-018363-qr1pk78u.txt item: #397 of 2876 id: cord-018408-ttae193b author: Haddad, Imad Y. title: Pneumonia and Empyema date: 2008-11-15 words: 6161 flesch: 29 summary: National Nosocomial Infections Surveillance System Prevalence of nosocomial infections in pediatric intensive care unit patients at US Children's Hospitals Fourth Decennial International Conference on Nosocomial and Healthcare-Associated Infections Clinical diagnosis of ventilator associated pneumonia revisited: comparative validation using immediate post-mortem lung biopsies Diagnosis of nosocomial bacterial pneumonia in acute, diffuse lung injury Management of bacterial pneumonia in ventilated patients. Finally, aspiration pneumonia caused by chronic inoculation of the lower respiratory tract with large amounts of less virulent bacteria in a susceptible host prone to aspiration is also observed in the PICU. keywords: aspiration; bacterial; children; diagnosis; disease; empyema; host; infections; infl; lung; patients; pleural; pneumonia cache: cord-018408-ttae193b.txt plain text: cord-018408-ttae193b.txt item: #398 of 2876 id: cord-018412-kv3vxmcw author: Bambi, Stefano title: Evolution of Intensive Care Unit Nursing date: 2017-10-06 words: 8547 flesch: 40 summary: The main lines of discussion in critical care nursing research should include nursing research priorities in critical care patients, holistic approaches to the patient, the humanization of care, special populations of ICU patients, and challenges related to critical care nursing during emerging outbreaks of infectious diseases. When ICU nurses were surveyed in regard to the elements that provided them with work satisfaction, they responded that the main elements were related to nursing unit management; the relationships with and the organization of medical staff; rostering practices; nurses roles in ICU patient care; and general relationships in the workplace [28] . keywords: care; environment; healthcare; hospital; icu; management; nurses; nursing; outcomes; patients; research; risk; staff; strategies; support; team; work; years cache: cord-018412-kv3vxmcw.txt plain text: cord-018412-kv3vxmcw.txt item: #399 of 2876 id: cord-018414-6ffhm895 author: Kang, Yoogoo title: Anesthesia Management of Liver Transplantation date: 2016-07-22 words: 21167 flesch: 28 summary: Liver transplantation requires a true multidisciplinary approach, and anesthesiologists and intensivists have played a major role in the successful outcome of liver transplantation. Right ventricular function during orthotopic liver transplantation Adult respiratory distress syndrome secondary to endstage liver disease-successful outcome following liver transplantation Use of intraoperative blood salvage during orthotopic liver transplantation Compression of the brachial plexus injury during right lobe liver donation as a cause of brachial plexus injury: a case report Rapid infusion devices for hemorrhagic cardiothoracic trauma Liver transplantation: effect of washing bank blood on intraoperative control of hyperkalemia Right heart dysfunction, pulmonary embolism, and paradoxical embolization during liver transplantation. keywords: administration; anesthesia; arterial; artery; blood; bypass; cardiac; coagulation; disease; dysfunction; et al; factors; failure; flow; function; hepatic; hypertension; ivc; level; liver; liver disease; liver transplantation; loss; output; patients; portal; pressure; reperfusion; right; serum; stage; syndrome; transplantation; vascular; vein; venous cache: cord-018414-6ffhm895.txt plain text: cord-018414-6ffhm895.txt item: #400 of 2876 id: cord-018430-u3k8pds6 author: Mason, Jay W. title: Myocarditis date: 2007 words: 21762 flesch: 28 summary: Evidence for a CD18-dependent mechanism Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils Interleukin-2: inception, impact, and implications Cytokines: coordinators of immune and inflammatory responses Induction of fibroblast proliferation by human mononuclear leukocyte-derived proteins Mechanisms of immune-mediated myocyte injury Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophageconditioned medium The role of the NO pathway in the control of cardiac function Contractile depression and expression of proinflammatory cytokines and iNOS in viral myocarditis The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis Suppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha Increased serum levels of circulating intercellular adhesion molecule-1 in patients with myocarditis Increased circulating cytokines in patients with myocarditis and cardiomyopathy Augmentation of pathogenesis of coxsackievirus B3 infections in mice by exogenous administration of interleukin-1 and interleukin-2 Detection of transforming growth factor-b1 in Coxsackie B3 virus-induced murine myocarditis Concepts of autoimmunity applied to idiopathic dilated cardiomyopathy Progressive interstitial collagen deposition in Coxsackievirus B3-induced murine myocarditis Myocardial remodeling in viral heart disease: Possible interactions between inflammatory mediators and MMP-TIMP system Prevention of encephalomyocarditis virus myocarditis in mice by inactivated virus vaccine Treatment of viral myocarditis with ribavirin in an animal preparation Ribavirin treatment of murine coxsackievirus B3 myocarditis with analysis of lymphocyte subsets Prevention of viral myocarditis with recombinant human leukocyte interferon alpha A/D in a murine model Modification of viral myocarditis in mice by interleukin-6 Effects of intranasal administration of recombinant murine interferon-gamma on murine acute myocarditis caused by encephalomyocarditis virus Effects of prednisolone on acute viral myocarditis in mice A nonsteroid anti-inflammatory drug exacerbates Coxsackie B3 murine myocarditis Coxsackievirus B3 murine myocarditis: deleterious effects of nonsteroidal anti-inflammatory agents Immunosuppression with high doses of cyclophosphamide reduces the severity of myocarditis but increases the mortality in murine Coxsackievirus B3 myocarditis Effect of delayed captopril therapy on left ventricular mass and myonecrosis during acute coxsackievirus murine myocarditis Impact of FK 506 on myocarditis in the enteroviral murine model Synergistic effects of tacrolimus and human interferon-alpha A/D in murine viral myocarditis Therapeutic effect of anti-tumor necrosis factor-alpha on the murine model of viral myocarditis induced by encephalomyocarditis virus Treatment of virus-induced myocardial injury with a novel immunomodulating agent, vesnarinone. Viral myocarditis is a triphasic process. keywords: abnormalities; acute; biopsy; cardiac; cardiomyopathy; cases; cell; cell myocarditis; chagas; chronic; dcm; death; diagnosis; disease; dysfunction; evidence; failure; giant; heart; heart disease; heart failure; incidence; infection; involvement; myocardial; myocarditis; myocyte; patients; phase; study; therapy; treatment; ventricular; virus cache: cord-018430-u3k8pds6.txt plain text: cord-018430-u3k8pds6.txt item: #401 of 2876 id: cord-018447-z4jyjczy author: D’Cruz, David P. title: Antiphospholipid (Hughes) Syndrome: An Overview date: 2006 words: 5169 flesch: 41 summary: Thus, Ruiz-Irastorza's study of over 200 SLE patients extending over 25 years demonstrated both higher damage scores and increased mortality in APS patients, most of whom had suffered arterial thromboses [32] . In the highest quartile of aCL patients, the odds ratio for myocardial infarct was significant at 2.0. keywords: acl; antiphospholipid; apl; aps; patients; risk; sle; syndrome; thrombosis cache: cord-018447-z4jyjczy.txt plain text: cord-018447-z4jyjczy.txt item: #402 of 2876 id: cord-018454-sy21cpff author: Mitrovic, Stéphane title: Adult-Onset Still’s Disease date: 2019-10-30 words: 9392 flesch: 38 summary: It is efficient in controlling AoSD disease activity and allowing for steroid dose sparing [3, [136] [137] Management of hereditary recurrent fevers-SHARE experience Complications of adult-onset Still's disease and their management Life-threatening complications of adult-onset Still's disease The evolution of adultonset Still disease: an observational and comparative study in a cohort of 76 Italian patients keywords: adult; adult onset; aosd; arthritis; cases; diagnosis; disease; ferritin; fever; il-1; onset; patients; refractory; serum; study; syndrome; systemic; treatment cache: cord-018454-sy21cpff.txt plain text: cord-018454-sy21cpff.txt item: #403 of 2876 id: cord-018545-fk17n2bx author: Dorofaeff, Tavey title: Infections in the PICU date: 2012 words: 14182 flesch: 43 summary: Bronchiolitis and other viral respiratory infections in infants with congenital heart disease lead to operative delays and increasing complications post cardiac bypass surgery (e.g., pulmonary hypertension). The following groups are at increased risk of severe infection: • Ex-premature infants and neonates • Infants with congenital heart disease • Infants with immune deficiency • Infants with neuromuscular disease keywords: antibiotics; care; cause; cell; children; days; diagnosis; disease; failure; fever; heart; hiv; illness; infants; infections; management; patients; picu; pneumonia; respiratory; risk; shock; syndrome; therapy; transplant; treatment; unit cache: cord-018545-fk17n2bx.txt plain text: cord-018545-fk17n2bx.txt item: #404 of 2876 id: cord-018590-rkp89dqo author: Lee, Chu Keong title: Narratives in Healthcare date: 2010-05-28 words: 4943 flesch: 52 summary: Second, the recuperative and relationship building roles of illness narratives are described. Illness narratives have become a major literary genre. keywords: experience; healthcare; illness; listening; narratives; organization; patient; physician; stories; story; time cache: cord-018590-rkp89dqo.txt plain text: cord-018590-rkp89dqo.txt item: #405 of 2876 id: cord-018595-x3tleomb author: Dodiuk-Gad, Roni P. title: Adverse Medication Reactions date: 2017-04-25 words: 16329 flesch: 37 summary: In view of the large diversity of cutaneous drug reactions, it is helpful to approach them as clinicopathologic entities and to base the diagnosis on a combination of clinical, histo- logical and disease course data [89] . Heightened awareness of the possible mimicry of other skin diseases and of the suspicious histopathological clues pointing to drug etiology are key elements to the appropriate histological diagnosis of drug reactions in the skin [85, 88, 89] . keywords: acute; adrs; carbamazepine; cases; cells; diagnosis; dress; drug; drug hypersensitivity; drug reactions; epidermal; eruption; hla; hypersensitivity; involvement; johnson; lesions; necrolysis; patients; reactions; sjs; skin; specific; stevens; study; symptoms; syndrome; treatment; type; urticaria cache: cord-018595-x3tleomb.txt plain text: cord-018595-x3tleomb.txt item: #406 of 2876 id: cord-018601-mk66097y author: Michelakis, Evangelos D. title: Pulmonary Arterial Hypertension date: 2007 words: 26309 flesch: 39 summary: Studying PAH pulmonary arteries with either a plexiform lesion or intimal or medial hypertrophy, one is impressed by the increased cellularity in the vascular wall. Pulmonary hypertensive patients may be intolerant to vasovagal reactions that may occur during attempted vascular access. keywords: arterial; arteries; artery; cells; channels; chronic; circulation; class; disease; effects; endothelial; fig; group; heart; hypertension; hypoxia; ipah; levels; lung; pah; pah patients; patients; pht; pressure; primary; pulmonary; right; sildenafil; study; survival; systemic; therapy; vascular; ventricular cache: cord-018601-mk66097y.txt plain text: cord-018601-mk66097y.txt item: #407 of 2876 id: cord-018620-3kqx8arn author: Rueda, Mario title: Hepatic Failure date: 2016-10-09 words: 13815 flesch: 42 summary: Besides parkinsonian movements and tremors, Kayser-Fleischer rings, psychiatric alterations, and renal problems, Wilson's disease will present with liver disease: cirrhosis, chronic failure without cirrhosis, and acute liver failure. Epidemiology of acute liver failure East meets west: acute liver failure in the global village The electroencephalograph in liver disease Low myo-inositol and high glutamine levels in brain are associated with neuropsychological deterioration after induced hyperammonemia Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure Branched-chain amino acids in liver diseases An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons Liver function, cerebral blood flow autoregulation, and hepatic encephalopathy in fulminant hepatic failure Difficult management problems in fulminant hepatic failure Incidence and pathophysiology of pulmonary edema in fulminant hepatic failure Pulmonary vascular complications of liver disease Hepatopulmonary syndrome: role of nitric oxide and clinical aspects Hepatorenal syndrome: pathophysiology and management Hepatorenal syndrome: a dreaded complication of end-stage liver disease Coagulopathy in liver diseases Mechanisms of water and sodium retention in cirrhosis and the pathogenesis of ascites Acute liver failure Acute liver failure Risk factors and outcomes of acute kidney injury in patients with acute liver failure Diagnosis and treatment of acute renal failure in patients with cirrhosis Lactic acidosis: recognition, kinetics, and associated prognosis Lactic acidosis Too much lactate or too little liver? Intensive care management of acute liver failure Patients with acute on chronic liver failure display sepsis-like immune paralysis Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess Effects of antimicrobial prophylaxis and blood stream infections in patients with acute liver failure: a retrospective cohort study The systemic inflammatory response syndrome in acute liver failure Infection and the progression of hepatic encephalopathy in acute liver failure Jaundice in older children and adolescents Update on the treatment of the pruritus of cholestasis Acute liver failure Medical palliation of the jaundiced patient with pruritus Acute hepatitis C AASLD position paper : the management of acute liver failure : update Propofol to control intracranial pressure in fulminant hepatic failure Management of fulminant hepatic failure in the USA: results from a survey of 14 liver transplant programs The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure The American experience with transplantation for acute liver failure Ammoniainduced brain edema and intracranial hypertension in rats after portacaval anastomosis Complications of intracranial pressure monitoring in fulminant hepatic failure Cerebral and cardiovascular responses to changes in head elevation in patients with intracranial hypertension Lactulose therapy in acute liver failure Efficacy of L-ornithine L-aspartate in acute liver failure: a double-blind, randomized. keywords: acetaminophen; acute; alf; ascites; bleeding; changes; cirrhosis; cld; disease; encephalopathy; failure; hepatic; hepatitis; infection; liver; liver failure; management; patients; results; serum; system; therapy; transplantation; treatment cache: cord-018620-3kqx8arn.txt plain text: cord-018620-3kqx8arn.txt item: #408 of 2876 id: cord-018623-of9vx7og author: Saghazadeh, Amene title: The Physical Burden of Immunoperception date: 2019-04-27 words: 5764 flesch: 31 summary: For example, emotional stress is ranked as the second most common neuropsychological cause of acute myocardial infarction (AMI) owing to its record in approximately 40-50% of these patients [30, 31] . A possible pathogenic pathway for metabolic syndrome is initiated by emotional stress and ensuing enhancement in the levels of proinflammatory cytokines, e.g., IL-1, IL-6, and TNF-α. keywords: activity; anxiety; behaviors; cytokines; disease; expression; il-6; levels; mice; model; patients; personality; stress; type cache: cord-018623-of9vx7og.txt plain text: cord-018623-of9vx7og.txt item: #409 of 2876 id: cord-018638-4pyjhpbk author: Pilania, Rakesh Kumar title: Kawasaki Disease date: 2019-10-30 words: 5677 flesch: 47 summary: The global epidemiology of Kawasaki disease: review and future perspectives Epidemiologic features of Kawasaki disease in Shanghai from Epidemiologic survey of Kawasaki disease in Jilin from 1999 through Epidemiological and clinical characteristics of Kawasaki disease and factors associated with coronary artery abnormalities in East China: nine years experience Epidemiologic study on Kawasaki disease in Beijing from Is Kawasaki disease incidence rising in Chandigarh Descriptive epidemiology of Kawasaki disease in Japan Genetics of Kawasaki disease: what we know and don't know The genetics of Kawasaki disease Dissecting Kawasaki disease: a state-of-the-art review Variations in ORAI1 gene associated with Kawasaki disease Transforming growth factor-beta signaling pathway in patients with Kawasaki disease Is Kawasaki disease an infectious disorder? Three linked vasculopathic processes characterize Kawasaki disease: a light and transmission electron microscopic study Histopathological aspects of cardiovascular lesions in Kawasaki disease Spatial and temporal clustering of Kawasaki syndrome cases The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition) Kawasaki disease in infants below 6 months: a clinical conundrum Arthritis presenting during the acute phase of Kawasaki disease BCG site reactivation in Kawasaki disease Controversies in diagnosis and management of Kawasaki disease Acute kidney injury in patients with Kawasaki disease Pulmonary presentation of Kawasaki disease-a diagnostic challenge Acute anterior uveitis as the presenting feature of Kawasaki disease Kawasaki disease as a cause of encephalitis Kawasaki disease and the pediatric gastroenterologist: a diagnostic challenge Pyuria in patients with Kawasaki disease High risk of coronary artery aneurysms in infants younger than 6 months of age with Kawasaki disease Mortality in children with Kawasaki disease: 20 years of experience from a tertiary care centre in North India Kawasaki disease in older children and adolescents Clinical assessment of coronary arteries in Kawasaki disease: focus on echocardiographic assessment Not just coronary arteritis, Kawasaki disease is a myocarditis, too Myocarditis and Kawasaki disease Early differentiation of Kawasaki disease shock syndrome and toxic shock syndrome in a pediatric intensive care unit Kawasaki disease in a pediatric intensive care unit: a case-control study Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan Kawasaki disease in India: increasing awareness or increased incidence? Biomarkers for diagnosis of Kawasaki disease Screening of differentially expressed genes associated with Kawasaki disease by microarray analysis Pro-brain natriuretic peptide (ProBNP) levels in North Indian children with Kawasaki disease Usefulness of natriuretic peptide for the diagnosis of Kawasaki disease: a systematic review and meta-analysis Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2013). keywords: acute; artery; caas; children; diagnosis; disease; fever; guidelines; kawasaki; patients; phase cache: cord-018638-4pyjhpbk.txt plain text: cord-018638-4pyjhpbk.txt item: #410 of 2876 id: cord-018714-i291z2ju author: Criado, Paulo Ricardo title: Adverse Drug Reactions date: 2016-12-31 words: 23933 flesch: 36 summary: This group of drug reactions includes anaphylaxis, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and, depending on the systemic involvement, erythroderma. This group of drug reactions includes anaphylaxis, SJS, TEN, drug hypersensitivity, and, depending on the systemic involvement, erythroderma, acute generalized exanthematous pustulosis (AGEP), cutaneous necrosis induced by anticoagulants, druginduced vasculitis, and reactions such as serum disease [4] . keywords: acute; agents; cases; cells; chemotherapeutic; chemotherapy; corticosteroids; days; diagnosis; dihs; disease; dress; drug; drug reactions; eccrine; edema; epidermal; eruption; erythema; fig; hla; immune; involvement; lesions; necrosis; onset; patients; reactions; reactivation; sjs; skin; symptoms; syndrome; treatment; type; use; vasculitis; weeks cache: cord-018714-i291z2ju.txt plain text: cord-018714-i291z2ju.txt item: #411 of 2876 id: cord-018780-zeok60hn author: Biddinger, Paul D. title: Evaluation of the Person Under Investigation date: 2018-07-07 words: 5766 flesch: 39 summary: In addition, depending upon the need to reduce risks to other patients and HCWs, regular laboratory and imaging equipment may not be available (or available at the standard frequency or turnaround time) to support medical care. The ability to detect and diagnose patients infected with a highly hazardous communicable disease (HHCD) must be a priority for healthcare facilities in order to limit the morbidity and mortality of infection and to ensure the safety of staff and other patients through the early initiation of appropriate infection prevention measures. keywords: care; disease; evaluation; infection; patient; pui; puis; room; staff cache: cord-018780-zeok60hn.txt plain text: cord-018780-zeok60hn.txt item: #412 of 2876 id: cord-018801-amet0wx4 author: Park, Caroline title: Care of the Patient with Liver Failure Requiring Transplantation date: 2018-05-04 words: 4708 flesch: 28 summary: Liver transplant patients may be eligible for fast-track extubation immediately postoperative in the operating room and upon arrival to the ICU. Liver transplant patients with hemorrhage that are undergoing appropriate blood product resuscitation and become hemodynamically unstable or develop abdominal compartment syndrome should return immediately to the operating room. keywords: acute; biliary; care; failure; graft; icu; liver; patients; risk; transplantation; treatment cache: cord-018801-amet0wx4.txt plain text: cord-018801-amet0wx4.txt item: #413 of 2876 id: cord-018809-3nrvm4jt author: McMullin, N. R. title: Hemostatic Resuscitation date: 2006 words: 6236 flesch: 43 summary: In the austere environment of combat the practice of fresh whole blood transfusion has proven beneficial to patients who are coagulopathic and require massive transfusion. Reports of the rapid positive response of recipients to fresh whole blood are thought-provoking and suggest profound possibilities for fresh whole blood transfusion. keywords: blood; coagulation; coagulopathy; fibrinogen; oxygen; patients; plasma; platelets; rbcs; resuscitation; rfviia; transfusion; units cache: cord-018809-3nrvm4jt.txt plain text: cord-018809-3nrvm4jt.txt item: #414 of 2876 id: cord-018834-4ligp4ak author: Farag, Ehab title: The Perioperative Use of Albumin date: 2016-06-23 words: 7564 flesch: 37 summary: The use of human albumin in critically ill and septic patients has been through much controversy in the last two decades. Rats received 2-h middle cerebral artery occlusion (MCAO) and were treated with human albumin or saline after 30 min of recirculation. keywords: acid; albumin; analysis; antioxidant; binding; blood; glycation; group; hsa; human; meta; mortality; patients; plasma; protein; sepsis; serum; use cache: cord-018834-4ligp4ak.txt plain text: cord-018834-4ligp4ak.txt item: #415 of 2876 id: cord-018840-ts2g1ux7 author: Katragkou, Aspasia title: Role of Immunoglobulin Therapy to Prevent and Treat Infections date: 2018-06-19 words: 6706 flesch: 26 summary: Randomized trial in bone marrow transplant recipients Guidelines for the use of human immunoglobulin therapy in patients with primary immunodeficiencies in Latin America Some but not all benefits of intravenous immunoglobulin therapy after marrow transplantation appear to correlate with IgG trough levels A new paradigm for the treatment of sepsis: is it time to consider combination therapy? Primary immune deficiencies (PIDD) are one of the US Food and Drug Administration (FDA)approved indications for immunoglobulin therapy. keywords: antibody; clinical; diseases; igg; immune; immunoglobulin; infections; intravenous; ivig; patients; sepsis; therapy; treatment; use cache: cord-018840-ts2g1ux7.txt plain text: cord-018840-ts2g1ux7.txt item: #416 of 2876 id: cord-018907-c84t1bo5 author: Bin-Hussain, Ibrahim title: Infections in the Immunocompromised Host date: 2012 words: 3647 flesch: 24 summary: The pathogens in immunocompromised patients can be predicted based on the immune defect. In centers dealing with immunocompromised patients, the microbiology laboratory as well as the radiology service need to be well equipped and trained in diagnosing these patients. keywords: culture; fever; gram; infection; negative; neutropenia; patients; risk; therapy cache: cord-018907-c84t1bo5.txt plain text: cord-018907-c84t1bo5.txt item: #417 of 2876 id: cord-019010-9xgwjvsv author: Luna, C. M. title: Life-threatening Respiratory Failure from H1N1 Influenza: Lessons from the Southern Cone Outbreak date: 2010-06-23 words: 4579 flesch: 30 summary: It remains unknown whether these cases were secondary to some of the several risk factors that these bed-ridden severely ill patients had, or whether it was a direct consequence of a particular risk in influenza patients. Renal failure has been described in a number of influenza patients [7, 31] . keywords: ards; h1n1; infection; influenza; pandemic; patients; peep; pneumonia; pressure; ventilation; virus cache: cord-019010-9xgwjvsv.txt plain text: cord-019010-9xgwjvsv.txt item: #418 of 2876 id: cord-019027-6chba2ru author: Schmidt, Michael G. title: Role of the Microbial Burden in the Acquisition and Control of Healthcare Associated Infections: The Utility of Solid Copper Surfaces date: 2014-07-12 words: 9040 flesch: 30 summary: The complexity and dynamic nature of the microbial pressure being introduced into the built clinical environment is dependent on stochastic nature inherent to healthcare The purpose of this chapter is to review the role of the environment of care as it pertains to microbial contamination and risk of HAI to patients as well as describe the novel use and efficacy of antimicrobial copper surfaces in mitigating this risk. Although the relative infection rate in the medical ICUs where the clinical effectiveness of antimicrobial copper surfaces were evaluated is generally higher than hospitals at large, patients in ICUs are typically not mobile, and their interaction with the built environment is very limited. keywords: bacteria; cleaning; contamination; control; copper; copper surfaces; environment; hai; healthcare; hospital; infection; pathogens; patient; risk; room; surfaces cache: cord-019027-6chba2ru.txt plain text: cord-019027-6chba2ru.txt item: #419 of 2876 id: cord-019043-cqmqwl3i author: Fidalgo, Pedro title: Chronic Kidney Disease in the Intensive Care Unit date: 2014-03-08 words: 8679 flesch: 26 summary: • CKD patients have a high prevalence of comorbid disease compared to non-CKD patients; however, CKD patients have reasonable short-term outcomes following ICU admission compared to non-CKD patients. The most common diagnoses contributing to ICU admission in CKD patients are sepsis and septic shock and decompensated cardiovascular disease. keywords: acute; aki; ckd; disease; esrd; esrd patients; fluid; icu; illness; kidney; mortality; patients; risk; rrt; sepsis; support; therapy cache: cord-019043-cqmqwl3i.txt plain text: cord-019043-cqmqwl3i.txt item: #420 of 2876 id: cord-019046-q6uv2ayi author: Hughes, Amy L. title: Laryngeal Infections date: 2015-07-14 words: 3591 flesch: 41 summary: key: cord-019046-q6uv2ayi authors: Hughes, Amy L.; Karter, Nicholas; Swanson, Douglas S. title: Laryngeal Infections date: 2015-07-14 journal: Infectious Diseases in Pediatric Otolaryngology DOI: 10.1007/978-3-319-21744-4_11 sha: doc_id: 19046 cord_uid: q6uv2ayi The following chapter is a review of the most common viral and bacterial etiologies of pediatric laryngeal infections. Pediatric patients with serious laryngeal candidiasis most often present with odynophagia, dysphagia and hoarseness, however they may present as an airway emergency. keywords: airway; children; croup; disease; infection; infl; patients; symptoms; treatment cache: cord-019046-q6uv2ayi.txt plain text: cord-019046-q6uv2ayi.txt item: #421 of 2876 id: cord-019063-mcxbl8mv author: Vijayan, Vannan K. title: Diagnosis of Pulmonary Parasitic Diseases date: 2013-06-05 words: 6672 flesch: 35 summary: World Health Organization Laboratory diagnosis of malaria infection-a short review of methods Malaria diagnosis: a brief review Rapid diagnostic tests for malaria parasites Rapid diagnostic testing for malaria A review of malaria diagnostic tools: microscopy and rapid diagnostic test (RDT) Co-infections acquired from Ixode ticks Acute respiratory failure in patients treated for babesiosis Diagnosis of pulmonary infection with Toxoplasma gondii in immunocompromised HIV-positive patients by real time PCR Clinical and diagnostic management of toxoplasmosis in the immunocompromised patient Eosinophilic lung disease in the tropics Parasitic diseases of the respiratory tract Spontaneous rupture of lung echinococcal cyst causing anaphylactic shock and respiratory distress syndrome Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD Pulmonary cystic echinococcosis Echinococcus multilocularis Disseminated alveolar echinococcosis mimicking a metastatic malignancy The immunodiagnosis of Echinococcus multilocularis infection Pulmonary schistosomiasis Pulmonary manifestations of early Schistosoma infection in nonimmune travelers Katayama fever; an acute manifestation of schistosomiasis Schistosomiasis associated pulmonary hypertension A diagnostic dilemma of right lower lobe collapse caused by pulmonary bilharsiasis Acute schistosomiasis in nonimmune travelers: chest CT fi ndings in 10 patients Pathophysiology, diagnosis, and treatment Detection of circulating antigens in patients with active Schistosoma haematobium infection Studies on clinical manifestations, diagnosis and control of paragonimiasis in China Pulmonary paragonimiasis: an evaluation of roentgen fi ndings in 38 positive sputum patients in an endemic area in Thailand Clinicoradiologic features of pleuropulmonary Paragonimus westermani on Kyushu Island Evaluation of human IgG subclass antibodies in the serodiagnosis of Paragonimus heterotremus Tropical parasitic lung diseases Strongyloidiasis and other intestinal nematode infections Eosinophilic lung disease (or how to slice PIE) Ascariasis and hookworm Possible approach for serodiagnosis of ascariasis by evaluation of immunoglobulin G4 response using Ascaris lumbricoides somatic antigen Nature and causes of hookworm anemia Differentiation between the human hookworm Ancylostoma duodenale and Necator americanus using PCR-RFLP Biology and immunology of human strongyloidiasis Disseminated Strongyloides stercoralis in human immunodefi ciency virus-infected patients: treatment failure and review of literature Pulmonary manifestations of strongyloidiasis Strongyloides stercoralis infestation associated with septicemia due to intestinal transmural migration of bacteria Corticosteroidinduced asthma: a manifestation of limited hyperinfection syndrome due to Strongyloides stercoralis Diagnosis of Strongyloides stercoralis infection A simple modification of the Baermann method for diagnosis of strongyloidiasis Evaluation of three methods for laboratory diagnosis of Strongyloides stercoralis infection Diagnosis of pulmonary strongyloidiasis by bronchoalveolar lavage Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area Tropical pulmonary eosinophilia Acute tropical pulmonary eosinophilia: characterization of the lower respiratory tract infl ammation and its response to therapy Tropical pulmonary eosinophilia: analysis of antifi larial antibody localized to the lung Pulmonary eosinophilia: progress in respiration research Tropical pulmonary eosinophilia Re-examination of the diagnostic criteria of tropical pulmonary eosinophilia In certain situations, invasive investigations such as fiberoptic bronchoscopic evaluation (transbronchial lung biopsies and bronchoalveolar lavage studies) and thoracic surgical procedures (thoracoscopy and open lung biopsy) may be required for a diagnosis and also to exclude other lung diseases. keywords: acute; blood; chest; detection; diagnosis; diseases; eosinophilia; histolytica; infection; lung; malaria; parasites; parasitic; patients; pulmonary; symptoms cache: cord-019063-mcxbl8mv.txt plain text: cord-019063-mcxbl8mv.txt item: #422 of 2876 id: cord-019064-e5z92vg8 author: Fox, Robert I. title: Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations date: 2011-04-12 words: 10976 flesch: 35 summary: In SS patients, the pattern of extraglandular manifestations may have a close similarity with the vasculitic features seen in SLE patients that are mediated by immune complexes and complement. However, SS patients also have an increased frequency of lymphocytic infiltration into extraglandular tissues, as might be expected by their increased frequency of lymphoma in comparison to SLE patients. keywords: anti; antibodies; autoimmune; dhea; diagnosis; disease; erythematosus; heart; interstitial; lupus; manifestations; patients; primary; sjogren; sle; ss patients; study; symptoms; syndrome; vasculitis cache: cord-019064-e5z92vg8.txt plain text: cord-019064-e5z92vg8.txt item: #423 of 2876 id: cord-019347-tj3ye1mx author: None title: ABSTRACT BOOK date: 2010-02-19 words: 108161 flesch: 50 summary: in allergic patients and 250 and 500 ug. In allergic patients after histamine threshold challenge mean decrease was for FEV1 19, 2% and for FEV1/VC 17, 3%. keywords: age; airway; allergen; allergic; allergy; allergy asthma; analysis; anti; antibody; asthma; asthma control; asthma diagnosis; asthma patients; asthma symptoms; atopic; background; baseline; blood; care; case; cd4; cells; chest; children; chronic; conclusion; control; daily; data; day; days; deficiency; desensitization; diagnosis; disease; dose; drug; effect; efficacy; evaluation; exposure; female; following; food; function; group; histamine; history; hours; ics; ige; igg; immune; improvement; increase; infections; inflammatory; introduction; levels; life; low; lung; male; mean; medical; medication; methods; minutes; months; nasal; negative; new; non; normal; number; objective; ova; patients; period; persistent; placebo; pollen; population; positive; prednisone; prevalence; prick; primary; production; pulmonary; quality; rate; reactions; recurrent; report; response; results; rhinitis; rhinitis patients; risk; serum; severity; significant; skin; specific; spray; studies; study; subjects; symptoms; syndrome; testing; tests; therapy; time; total; treatment; urticaria; use; visits; weeks; wheezing; years cache: cord-019347-tj3ye1mx.txt plain text: cord-019347-tj3ye1mx.txt item: #424 of 2876 id: cord-019490-m1cuuehi author: None title: Abstracts cont. date: 2015-12-28 words: 93719 flesch: 45 summary: Mean age (78 vs 77), Charlson score (2.5 vs. 2.6), neoplasm (22% vs. 21%), HIV (0.7% vs. 0.8%), chronic liver disease (9% vs.7%), diabetes mellitus ( 19% vs.22%), ICU admission (4% vs. 4%), monotherapy (63% vs. 66%), and aetiology (S. pneumoniae 34% vs. 36%; L. pneumophila 3% vs.2%; others 8% vs.11%; unknown 54% vs.51%) were similar. The same was found for mecillinam, i.e. no correlation for AUC/MIC vs. CFÚ s in urine or organs, while Time > MIC % significantly (P < 0.05) correlated with CFÚ s in urine (R 2 = 0.48), and kidney tissue (R 2 = 0.82), respectively. keywords: activity; aeruginosa; agar; agents; aim; analysis; anthrax; antibiotics; antimicrobial; assay; associated; aureus; bacteria; blood; broth; cases; ciprofloxacin; clinical; coli; concentrations; conclusions; control; data; days; detection; diagnosis; disease; dose; drug; effect; erythromycin; gene; gram; grn; group; hospital; hours; human; imipenem; infections; isolates; laboratory; levofloxacin; linezolid; low; mcg; mean; methicillin; methods; mic; mic90; mics; moxifloxacin; mrsa; mrsa strains; nccls; negative; new; non; objectives; oral; pathogens; patients; pcr; penicillin; period; pfge; phenotype; plasma; pneumoniae; population; positive; presence; prevalence; pylori; rates; resistance; results; risk; s. aureus; samples; serum; single; skin; species; spectrum; spp; staphylococcus; strains; studies; study; subjects; susceptibility; susceptible; tested; testing; therapy; tigecycline; time; tissue; total; tract; treatment; type; use; values; vancomycin; vitro; water; years cache: cord-019490-m1cuuehi.txt plain text: cord-019490-m1cuuehi.txt item: #425 of 2876 id: cord-019964-9leljj8j author: None title: Recent research in infectious disease date: 2005-01-22 words: 6121 flesch: 44 summary: We examined the risk of developing HSIL among adolescents with and without HIV infection. Methods: HIV-infected (nZ172) and-uninfected (nZ84) girls aged 13-18 years who were participating in a multicenter study of primarily horizontally acquired HIV infections in adolescents (Reaching for Excellence in Adolescent Health Care) and who did not have HSIL on cytologic examination at study entry or at the first follow-up visit were followed at 6-month intervals. Results: At the STI clinic (nZ756 men), we identified 150 men (20%) with Trichomonas vaginalis infection, 358 men (47%) with HIV infection, and 335 men (44%) with Neisseria gonorrhoeae infection. keywords: cases; children; group; gynecomastia; hiv; infected; infection; isolates; men; mrsa; patients; results; risk; study; use; virus; years cache: cord-019964-9leljj8j.txt plain text: cord-019964-9leljj8j.txt item: #426 of 2876 id: cord-019968-o5bdb37q author: Goldwater, Paul N. title: Gastroenteritis in Auckland: An aetiological and clinical study date: 2005-04-14 words: 3585 flesch: 44 summary: The features of most cases of rotavirus gastroenteritis and non-rotavirus gastroenteritis were so similar that a separate aetiology for each group could not be distinguished on clinical evidence. On the whole, rotavirus gastroenteritis patients required intravenous fluids more often than the non-rotavirus group, but the numbers of patients in each group are small, Control patients had mainly respiratory infections and other non-diarrhoeal conditions. keywords: cent; control; diarrhoea; gastroenteritis; groups; non; particles; patients; rotavirus; stools cache: cord-019968-o5bdb37q.txt plain text: cord-019968-o5bdb37q.txt item: #427 of 2876 id: cord-020342-u8jzmloq author: None title: Index to volume 42, January–June 2003() date: 2003-11-20 words: 3794 flesch: -2 summary: Sánchez M (see Coll-Vinent et al) Sanou BT (see van Alem et al) Utility of emergency department cervical magnetic resonance imaging in evaluation of cervical spine injury Saver JL (see Eckstein et al) Schafermeyer RW (see Pollack et al) Schauer BA (see Palchak et al) Barriers to donation after cardiac death: a national focus group study of health care professionals Scheatzle MD (see Caterino and Scheatzle) The emergency medicine workforce Antiemetic therapy in US emergency departments: findings from the year 2000 National Hospital Ambulatory Medical Care Survey database Elevated blood lead levels associated with the consumption of moonshine among emergency department patients in Detecting a subarachnoid hemorrhage by measuring cerebrospinal fluid bilirubin in patients with normal computed tomography scans Indications for brain hypothermic therapy in cardiac arrest patients Emergency physician compliance with annual purified protein derivative testing Morrison L (see Bandiera et al) Mower W (see Bracken et al) Mower W (see Medzon et al) Muelleman RL (see Wadman et al) AC (see Sullivan et al) Alternative for automated communication in research Neumar RW (see Pollack et al) When is a patient safe for discharge after procedural sedation? keywords: abst; acute; care; department; effect; emergency; et al; failure; forum; hospital; medicine; pain; patients; pollack; research; risk; trauma; treatment; use cache: cord-020342-u8jzmloq.txt plain text: cord-020342-u8jzmloq.txt item: #428 of 2876 id: cord-021075-8hba6au3 author: Ouallet, J.-C. title: Aspects cliniques, physiopathologiques, et thérapeutiques de la sclérose en plaques date: 2004-07-29 words: 25150 flesch: 59 summary: L'existence de complexes IgG-C3d sur les cellules microgliales pourrait constituer la marque de la lésion primitive de la SEP. Ces manifestations durent quelques dizaines de secondes et sont très évocatrices de la SEP. keywords: alors; anticorps; atteinte; aux; ayant; cas; cellules; cependant; ces; cette; chez; clinique; comme; contre; cours; critères; d'autres; d'une; dans; dans la; de la; de sep; des; deux; diagnostic; données; dose; début; effet; elle; entre; est; et la; fait; formes; groupe; handicap; irm; l'existence; l'ifn; l'irm; l'étude; l'évolution; la sep; lcr; les; leur; lésions; mais; maladie; mois; montré; même; n'est; nombre; non; par; parfois; pas; patients; peut; peuvent; phase; placebo; plaques; pour; poussées; progressive; présence; prévalence; que; quelques; qui; risque; récemment; résultats; rôle; sans; sclerosis; sclérose; selon; sep; soit; sont; sous; souvent; sur; traitement; trois; troubles; très; type; une; également; était; études; été; être cache: cord-021075-8hba6au3.txt plain text: cord-021075-8hba6au3.txt item: #429 of 2876 id: cord-021087-n4epxwn9 author: None title: ECR – Final Programme: Scientific and Educational Exhibits date: 2004 words: 154405 flesch: 43 summary: With more thorough information derived from HRCT and biopsy on the types of tumors patients have, physicians can offer patients more accurate prognosis. Imaging Findings: In normal patients, the fractional anisotropy (FA) maps clearly visualized white matter tracts as areas of high FA compared to gray matter. keywords: abnormalities; accuracy; acute; analysis; angiography; aortic; appearances; area; arterial; arteries; artery; assessment; axial; background; benign; biopsy; blood; bone; bowel; brain; breast; cancer; carcinoma; cardiac; carotid; cases; cell; cerebral; changes; chest; children; chronic; common; complications; conclusion; contrast; contrast enhancement; coronary; correlation; ct angiography; ct findings; ct images; ct imaging; ct scans; cta; cystic; cysts; data; details; detection; diagnosis; diameter; difference; diffusion; disease; doppler; dose; echo; enhancement; evaluation; examination; fat; features; findings; flow; follow; following; group; hepatic; high; hrct; images; imaging; imaging features; imaging findings; information; injection; intensity; involvement; learning; left; lesions; level; liver; lung; malignant; masses; materials; mean; medical; methods; months; mr images; mr imaging; mra; mri; mri findings; msct; multi; myocardial; n =; nodules; non; normal; number; objectives; p =; parameters; pathology; patients; pattern; perfusion; pet; phase; post; presence; present; primary; procedure; protocol; pulmonary; purpose; quality; radiation; radiologists; range; rate; ray; reconstruction; renal; resolution; resonance; respectively; results; review; right; role; row ct; scan; sensitivity; sequences; signal; size; slice; specificity; spectrum; spiral ct; standard; stenosis; studies; study; subjects; surgery; syndrome; system; technique; therapy; thickness; time; tissue; tomography; treatment; tumor; type; ultrasound; underwent; use; value; vascular; vessels; volume; wall; weighted; women; years cache: cord-021087-n4epxwn9.txt plain text: cord-021087-n4epxwn9.txt item: #430 of 2876 id: cord-021206-4zyqqgs0 author: None title: Scientific and Educational Exhibits date: 2007 words: 138880 flesch: 44 summary: Conclusion: In the appropriate clinical setting, CT fi ndings in immunologic lung diseases other than asthma and collagen-vascular disorders are suggestive of the underlying disorders and allow in making the correct diagnosis with a reasonable level of confi dence. CT fi ndings combined with certain histopathologic features can suggest specifi c diagnosis. keywords: abdominal; abnormalities; accuracy; acute; adc; analysis; anatomy; angiography; aortic; approach; arterial; arteries; artery; assessment; associated; background; benign; biopsy; blood; body; bone; bowel; brain; breast; cancer; cancer patients; carcinoma; cardiac; cases; changes; chest; classifi; complications; conclusion; conditions; confi; contrast; coronary; correlation; ct angiography; ct fi; ct images; cta; data; defi; details; detection; diagnosis; diameter; diffusion; disease; doppler; dose; dynamic; echo; enhancement; evaluation; examination; exhibit; fat; fi eld; fi ndings; fi rst; follow; group; heart; high; identifi; images; imaging; imaging features; imaging fi; infl; information; injection; involvement; learning; left; lesions; low; lung; malignant; management; masses; materials; mdct; mean; methods; mr images; mr imaging; mri; mri fi; new; nodes; non; normal; number; objectives; parameters; pathology; patients; pattern; perfusion; pet; phase; post; presence; primary; procedure; protocol; pulmonary; purpose; quality; radiation; radiological; radiologists; rate; renal; resolution; resonance imaging; results; review; right; risk; role; scan; sequences; signal; signifi; size; slice; specifi; spectrum; standard; stenosis; structures; studies; study; surgery; system; technique; test; therapy; thickness; time; tissue; total; treatment; tumors; type; ultrasound; use; value; vascular; venous; volume; wall; years cache: cord-021206-4zyqqgs0.txt plain text: cord-021206-4zyqqgs0.txt item: #431 of 2876 id: cord-021571-7kbq0v9w author: Heath, Joan A. title: Infections Acquired in the Nursery: Epidemiology and Control date: 2009-05-19 words: 21253 flesch: 30 summary: Because control over birth weight-the most significant predictor of nosocomial infection risk-is limited, proper NICU customs, environment, and procedures (e.g., hand hygiene, antimicrobial usage, catheter-related practices, skin and cord care, visitation policies, unit design, and staffing) can reduce the risk for infection in the NICU. This chapter describes the epidemiology, etiology, and clinical characteristics of neonatal nosocomial infections as well as the methods required for effective infection prevention and control. keywords: birth; bloodstream; breast; care; care unit; catheter; colonization; contact; control; data; hand; hcws; hospital; hygiene; infants; infection; infection control; milk; neonatal; neonates; nicu; nosocomial; nursery; outbreak; patient; pneumonia; precautions; rates; respiratory; risk; study; transmission; unit; use; weight cache: cord-021571-7kbq0v9w.txt plain text: cord-021571-7kbq0v9w.txt item: #432 of 2876 id: cord-021701-yan5q2r7 author: Woolard, Robert H. title: Emergency Department Design date: 2009-05-15 words: 4084 flesch: 47 summary: Evacuation of ED patients has been addressed by ED designers. Anticipated computing needs for ED operations during disaster events are immense. keywords: access; air; areas; disaster; eds; event; information; patients; space; system; terror cache: cord-021701-yan5q2r7.txt plain text: cord-021701-yan5q2r7.txt item: #433 of 2876 id: cord-021713-e0hzcag6 author: None title: Ribavirin date: 2015-10-21 words: 10946 flesch: 34 summary: A randomized double-blind study A controlled trial of aerosolized ribavirin in infants receiving mechanical ventilation for severe respiratory syncytial virus infection Adverse effects and other safety aspects of the hepatitis C antivirals Iatrogenic hyperpigmentation in chronically infected hepatitis C patients treated with pegylated interferon and ribavirin Anecdotes that provide definitive evidence Severe autoimmune hemolytic anemia complicated with liver decompensation and invasive aspergillosis in a patient with chronic hepatitis C during treatment with peg-interferon-a and ribavirin Pneumonitis as a consequence of (peg)interferon-ribavirin combination therapy for hepatitis C: a review of the literature Development of ocular myasthenia during pegylated interferon and ribavirin treatment for chronic hepatitis C Pleural effusion associated with pegylated interferon alpha and ribavirin treatment for chronic hepatitis C Pegylated interferon and ribavirin therapy for hepatitis C causing cataract Pegylated IFN-alpha2b plus ribavirin as therapy for chronic hepatitis C in HIV-infected patients Hepatitis C virus RNA kinetics during the initial 12 weeks treatment with pegylated interferon-alpha 2a and ribavirin according to virological response Alpha interferon and ribavirin combination therapy of chronic hepatitis D HIV/hepatitis C virus-coinfected virologic responders to pegylated interferon and ribavirin therapy more frequently incur interferon-related adverse events than nonresponders do Should living donor liver transplantation be offered to patients with hepatitis C virus cirrhosis? The effect and safety of the treatment of recurrent hepatitis C infection after orthotopic liver transplantation with pegylated interferon a2b and ribavirin Side effects of the therapy with peginterferon and ribavirin in chronic hepatitis C: a small audit Does interferon and ribavirin combination therapy increase the rate of treatment response in children with hepatitis C? Effects of adding ribavirin to interferon to treat chronic hepatitis C infection: a systematic review and meta-analysis of randomized trials Treatment of hepatitis C virus-related systemic vasculitis PEGylated interferon alfa-2b and ribavirin treatment in patients with hepatitis C virus-related systemic vasculitis Chronic cough associated with interferon/ribavirin therapy for hepatitis C Dyspnoea in patients with chronic hepatitis C treated with pegylated interferon and ribavirin Bronchial casts attributed to the use of pegylated interferon and ribavirin Expectoration of large bronchial casts secondary to the treatment of chronic hepatitis C with pegylated interferon and ribavirin Severe migraine headaches are caused by ribavirin but not by interferon alpha-2B in combination therapy for chronic hepatitis C Progressive multifocal leukoencephalopathy as a complication of hepatitis C virus treatment in an HIVnegative patient Recovery after L-DOPA treatment in peginterferon and ribavirin induced parkinsonism Bell's palsy associated with chronic HCV infection before and during peginterferon alfa and ribavirin therapy Seizures during pegylated interferon and ribavirin therapy for chronic hepatitis C: observations from the WIN-R trial Trombosis venosa retiniana asociada a peginterferó n alfa 2b má s ribavirina en un paciente con hepatitis C cró nica Incidence and risk factors of retinopathy in Egyptian patients with chronic hepatitis C virus treated with pegylated interferon plus ribavirin Retinopatía asociada a interferó n pegilado y ribavirina en pacientes con hepatitis C Retinopathy associated with pegylated interferon and ribavirin causing permanent visual impairment in a patient with chronic hepatitis C Branch retinal artery occlusion and central retinal vein occlusion associated with pegylated interferon plus ribavirin combination therapy for chronic hepatitis C Serous retinal detachments complicating interferon-alpha and ribavirin treatment in patients with hepatitis C Vogt-Koyanagi-Harada disease occurring during pegylated interferon-alpha2b and ribavirin combination therapy for chronic hepatitis C Anterior ischemic optic neuropathy in a patient with hepatitis C treated with interferon-alpha and ribavirin Retinopathy associated with pegylated interferon and ribavirin treatment for chronic hepatitis C Interferonalpha-2b/ribavirin-induced vestibulocochlear toxicity with dysautonomia in a chronic hepatitis C patient Reversible sudden sensorineural hearing loss during chronic hepatitis C treatment with pegylated interferon/ ribavirin Pegylated interferon/ribavirin-associated sudden hearing loss in a patient with chronic hepatitis C in Brazil keywords: alfa; anemia; chronic; chronic hepatitis; combination; hepatitis; infection; interferon; months; patients; peginterferon; ribavirin; therapy; treatment; virus; weeks; year cache: cord-021713-e0hzcag6.txt plain text: cord-021713-e0hzcag6.txt item: #434 of 2876 id: cord-021721-80pp1ra4 author: Woolard, Robert H. title: Emergency Department Design date: 2015-10-23 words: 5351 flesch: 45 summary: Evacuation of ED patients has been addressed by ED designers. Some ED design lessons have been learned from disaster events. keywords: access; air; areas; capacity; decontamination; disaster; eds; emergency; event; hospital; information; patients; response; system cache: cord-021721-80pp1ra4.txt plain text: cord-021721-80pp1ra4.txt item: #435 of 2876 id: cord-021742-sdz6d1r5 author: Karnik, Ankur A. title: Pneumothorax and Barotrauma date: 2009-05-15 words: 13485 flesch: 36 summary: A multicenter, prospective, randomized pilot study Simple aspiration versus chest-tube insertion in the management of primary spontaneous pneumothorax: A systematic review Chest tubes: indications, techniques, management and complications Recurrent re-expansion pulmonary edema Chest tube removal: End-inspiration or end-expiration? Delayed pulmonary perforation: A rare complication of the tube thoracostomy Complications of percutaneous dart therapy in management of pneumothorax Treatment of pneumothoraces utilizing small caliber chest tubes Role of small caliber chest tube drainage for iatrogenic pneumothorax Pigtail tube drainage in the treatment of spontaneous pneumothorax The thoracic vent: Clinical experience with a new device for treating simple pneumothorax Use of a pleural catheter for the management of simple pneumothorax Spontaneous pneumothorax Spontaneous pneumothorax in Norfolk Management of secondary spontaneous pneumothorax. Effects on recurrence and lung transplantation complications Persistent air leak in spontaneous pneumothorax-clinical course and outcome A prospective algorithm for the management of air leaks after pulmonary resection Autologous blood patch pleurodesis for persistent pulmonary air leak Autologous blood patch pleurodesis for secondary spontaneous pneumothorax with persistent air leak Intrapleural administration of a large amount of diluted fi brin glue for intractable pneumothorax Medical management and therapy of bronchopleural fi stulas in the mechanically ventilated patient Pectoral myoplasty for recurrent pneumothorax: An extrathoracic solution to an intrathoracic problem The treatment of refractory pneumothorax in diffuse panbronchiolitis by intravenous administration of coagulation factor XIII concentrate Closure of a bronchopleural fi stula using bronchoscopic placement of an endobronchial valve designed for the treatment of emphysema Acute pulmonary edema following treatment of spontaneous pneumothorax with excessive negative intrapleural pressure Clinical analysis of reexpansion pulmonary edema Unilateral pulmonary edema resulting from treatment of spontaneous pneumothorax Experimental pulmonary edema following re-expansion of pneumothorax Evidence for increased permeability in reexpansion pulmonary edema Changes in pulmonary microvascular permeability accompanying re-expansion oedema: keywords: air; aspiration; barotrauma; bilateral; cases; chest; colleagues; complication; disease; lung; management; needle; patients; pleural; pleurodesis; pneumothoraces; pneumothorax; pressure; recurrence; risk; syndrome; thoracentesis; treatment; tube cache: cord-021742-sdz6d1r5.txt plain text: cord-021742-sdz6d1r5.txt item: #436 of 2876 id: cord-021816-gk8rwyq4 author: Weinberger, Steven E. title: Pneumonia date: 2018-02-22 words: 7588 flesch: 31 summary: key: cord-021816-gk8rwyq4 authors: Weinberger, Steven E.; Cockrill, Barbara A.; Mandel, Jess title: Pneumonia date: 2018-02-22 journal: Principles of Pulmonary Medicine DOI: 10.1016/b978-0-323-52371-4.00026-x sha: doc_id: 21816 cord_uid: gk8rwyq4 By nearly any criteria, pneumonia (infection of the pulmonary parenchyma) must be considered one of the most important categories of disease affecting the respiratory system. Bacterial pneumonias in particular are characterized by an exuberant outpouring of PMNs into alveolar spaces as they attempt to limit proliferation of the invading bacteria. keywords: bacteria; cases; cause; clinical; community; disease; gram; infection; lung; organisms; patients; pneumonia; treatment cache: cord-021816-gk8rwyq4.txt plain text: cord-021816-gk8rwyq4.txt item: #437 of 2876 id: cord-021905-fjcks7w4 author: Win, Patrick H. title: Asthma Triggers: What Really Matters? date: 2009-05-22 words: 5995 flesch: 39 summary: After asthma triggers are identified and confirmed with testing (if necessary), every effort should be made to avoid or eliminate these specific triggers of asthma symptoms (with the exception of exercise). Irritant: Any substance, chemical, or physical factor that triggers asthma symptoms by nonspecific mechanisms resulting in increased bronchial hyperreactivity. keywords: allergen; asthma; cat; dust; exposure; house; individuals; mite; mold; patients; pollen; symptoms; triggers cache: cord-021905-fjcks7w4.txt plain text: cord-021905-fjcks7w4.txt item: #438 of 2876 id: cord-021917-z9wpjr0d author: Stephens, R. Scott title: Bioterrorism and the Intensive Care Unit date: 2009-05-15 words: 8262 flesch: 42 summary: Finally, other patients in the ICU are immunocompromised by virtue of their own critical illnesses, notwithstanding the disproportionate number of ICU patients who are immunosuppressed secondary to organ transplantation, oncologic conditions, or infection with the human immunodeficiency virus (HIV). Hands must be washed after each patient contact even when protective gloves are used because a surprisingly high percentage of protective gloves contain microscopic holes, and holes may develop during the activities of routine patient care. keywords: agents; anthrax; care; days; disease; equipment; event; exposure; health; medical; patients; plague; smallpox; victims cache: cord-021917-z9wpjr0d.txt plain text: cord-021917-z9wpjr0d.txt item: #439 of 2876 id: cord-022050-h24f0fpd author: Naughton, Matthew T. title: Acute Exacerbations of Chronic Obstructive Pulmonary Disease and Asthma date: 2009-05-15 words: 7004 flesch: 39 summary: The mortality of COPD patients admitted to the hospital is 15%, exceeding that for myocardial infarction. COPD patients liberated from invasive ventilatory support may also benefit from NIV, although studies have questioned the utility of its use in this setting. keywords: airflow; airway; asthma; chronic; copd; disease; exacerbations; expiratory; failure; hyperinflation; patients; pressure; rate; ventilation; volume cache: cord-022050-h24f0fpd.txt plain text: cord-022050-h24f0fpd.txt item: #440 of 2876 id: cord-022103-4zk8i6qb author: Siegel, Jane D. title: Pediatric Healthcare Epidemiology date: 2017-07-18 words: 12636 flesch: 23 summary: A systematic evaluation Outbreak of extended-spectrum betalactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit: a systematic review of risk factors and environmental sources Preventing the spread of pertussis in pediatric healthcare settings Healthcare providers as sources of vaccine-preventable diseases Respiratory viral detection in children and adults: comparing asymptomatic controls and patients with community-acquired pneumonia Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis The prevalence and molecular epidemiology of multidrug-resistant Enterobacteriaceae colonization in a pediatric intensive care unit Recognition and prevention of multidrug-resistant gram-negative bacteria in the intensive care unit Epidemiology and clinical outcomes of multidrug-resistant gram-negative bloodstream infections in a European tertiary pediatric hospital during a 12-month period Trends in Candida central line-associated bloodstream infections among NICUs Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America Empiric antifungal therapy and outcomes in extremely-low-birth-weight infants with invasive candidiasis Necessary infrastructure of infection prevention and healthcare epidemiology programs: a review Patient safety: infection control: a problem for patient safety Guidance for infection prevention and healthcare epidemiology programs: healthcare epidemiologist skills and competencies New Delhi metallo-β-lactamase-producing carbapenem-resistant Escherichia coli associated with exposure to duodenoscopes Fungal infections associated with contaminated methylprednisolone injections The scientific basis for using surveillance and risk factor data to reduce nosocomial infection rates Feeding back surveillance data to prevent hospital-acquired infections Statistical process control as a tool for research and healthcare improvement National Healthcare Safety Network report, data summary for 2013, device-associated module Lack of patient understanding of hospitalacquired infection data published on the Centers for Medicare and Medicaid Services Hospital Compare website Compliance with prevention practices and their association with central line-associated blood stream infections in neonantal intensive care units Guidance on public reporting of healthcareassociated infections: recommendations of the Healthcare Infection Control Practices Advisory Committee Reconsidering contact precautions for endemic methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus Approaches for preventing healthcareassociated infections: go long or go wide? Oversight of risk assessment and implementation of preventive measures associated with construction, renovation, and other environmental conditions associated with increased infection risk 6. keywords: agents; children; contact; control; exposure; facilities; hais; hcp; healthcare; hospital; infection; influenza; ipc; pathogens; patients; pediatric; precautions; prevention; recommendations; risk; safety; settings; transmission; use; virus cache: cord-022103-4zk8i6qb.txt plain text: cord-022103-4zk8i6qb.txt item: #441 of 2876 id: cord-022119-bzd9e1q6 author: Orzell, Susannah title: Pharyngitis and Pharyngeal Space Infections: fever, sore throat, difficulty swallowing date: 2018-10-15 words: 7316 flesch: 42 summary: Deep neck space infections can also extend directly into the mediastinum or the lungs causing life-threatening mediastinitis or pneumonia, underscoring the importance of early recognition and treatment. For example, dental infections are the most common source and predisposing factor for deep neck space infections in adults, but tonsillitis and pharyngitis are the most common predisposing factor among children [10] [11] [12] . keywords: abscesses; airway; antibiotics; diagnosis; infection; neck; neck space; parapharyngeal; patients; pharyngitis; space; throat; treatment cache: cord-022119-bzd9e1q6.txt plain text: cord-022119-bzd9e1q6.txt item: #442 of 2876 id: cord-022173-kb6mez61 author: Calvillo Batllés, P. title: Hematologic neoplasms: Interpreting lung findings in chest computed tomography() date: 2015-11-06 words: 5376 flesch: 29 summary: 18-FDG PET-CT is not only useful for the staging and follow up of metabolically-active lymphomas 69 but also a pathological uptake in the absence of pulmonary findings in the HRCT can raise early suspicion of drug toxicity 70, 71 or leukemic infiltration and it can be useful to differentiate active lesion scarring (whether toxic, infectious or tumoral). Expiration Before-HPT Rituximab is an anti-CD20 monoclonal antibody used in the treatment of lymphoproliferative B syndromes that have been associated to pulmonary disease due to a mechanism that has not been clarified yet after a median of four cycles and with a median time of appearance of 4 weeks after the last infusion. keywords: diagnosis; disease; findings; hpt; nodes; patients; pneumonia; pulmonary; tomography; treatment cache: cord-022173-kb6mez61.txt plain text: cord-022173-kb6mez61.txt item: #443 of 2876 id: cord-022216-k4pi30sd author: Kliegman, Robert M. title: Neonatal necrotizing enterocolitis date: 2009-05-15 words: 6112 flesch: 26 summary: The treatment of severe NEC manifested as SIRS is not unlike that of other causes of bacteremia-associated hypotension. 1, 16 Involvement of the jejunum, stomach or entire length of bowel from the ligament of Treitz to the rectum is less common (seen in 10% of surgical cases); the latter is present in fatal cases of NEC (also known as pan-NEC or NEC totalis). keywords: blood; disease; enterocolitis; incidence; infants; mucosal; nec; necrotizing; neonatal; oxygen; patients; risk cache: cord-022216-k4pi30sd.txt plain text: cord-022216-k4pi30sd.txt item: #444 of 2876 id: cord-022292-msz4au4b author: Gershan, William M. title: Cough date: 2009-05-15 words: 13127 flesch: 45 summary: False-negative results of sweat tests can be seen in CF children presenting with edema or hypoproteinemia and in samples from children with an inadequate sweat rate. Similarly, pansinusitis is nearly universal among CF patients but is quite uncommon in other children. keywords: airway; aspiration; asthma; blood; bronchoscopy; cases; cause; chest; child; children; cough; diagnosis; disease; infants; infection; lung; patients; pneumonia; pulmonary; table; treatment cache: cord-022292-msz4au4b.txt plain text: cord-022292-msz4au4b.txt item: #445 of 2876 id: cord-022501-9wnmdvg5 author: None title: P1460 – P1884 date: 2015-12-28 words: 128422 flesch: 46 summary: In the first half-year of 2005 family doctors most often prescribed penicyllins -(44.8%), makrolids -(27.1%), cephalosporins -(12.5%), tetracyclins -(9.4%) and lincozamidsbased (3.1%) treatments Specialist doctors, on the other hand, prescribed penicllins (41.7%), makrolids (17.9%), cephalosporins (17.7%), tetracyclins (12.1%), lincozamids (5.2%) and chinolons (3%). State-wide antibiotic consumption in the AC setting during the same time was 12 DID (~85% of total consumption). keywords: acid; activity; acute; aeruginosa; agar; age; agents; aim; analysis; antibiotic; antimicrobial; assay; aureus; bacteria; beta; blood; care; cases; cause; cfu; children; ciprofloxacin; clinical; coli; common; community; concentrations; conclusion; consumption; control; cost; culture; daily; data; days; detection; diagnosis; diarrhoea; differences; different; difficile; disease; distribution; dna; dose; drug; duration; effect; efficacy; erythromycin; factors; faecium; following; frequency; gene; gram; group; guidelines; health; hospital; hours; human; identification; imipenem; incidence; increase; infections; information; isolates; laboratory; level; levofloxacin; linezolid; mean; medical; meningitis; methicillin; methods; mic; mics; model; months; mortality; moxifloxacin; mrsa; n =; negative; new; non; number; objectives; pathogens; patients; pcr; penicillin; period; phenotype; pneumoniae; population; positive; presence; prevalence; protein; range; rates; resistance; respiratory; results; risk; s. aureus; samples; sequence; sequencing; serum; skin; species; specific; specimens; spectrum; spp; standard; staphylococcus; strains; streptococcus; studies; study; subjects; susceptibility; susceptible; test; tetracycline; therapy; tigecycline; time; tissue; total; toxin; tract; treatment; type; use; values; vancomycin; vitro; years cache: cord-022501-9wnmdvg5.txt plain text: cord-022501-9wnmdvg5.txt item: #446 of 2876 id: cord-022521-r72jtoso author: Miller, Tracie L. title: Gastrointestinal Complications of Secondary Immunodeficiency Syndromes date: 2010-12-27 words: 13743 flesch: 30 summary: Ganciclovir: an update of its use in the prevention of cytomegalovirus infection and disease in transplant recipients Safety and efficacy of prolonged cytomegalovirus prophylaxis with intravenous ganciclovir in pediatric and young adult lung transplant recipients Hepatitis B in the HIV-coinfected patient Hepatitis B or hepatitis C and human immunodeficiency virus infection Influence of HIV infection on the response to interferon therapy and the long-term outcome of chronic hepatitis B Effect of duration of hepatitis B virus infection on the association between human immunodeficiency virus type-1 and hepatitis B viral replication Hepatitis B virus infection in the acquired immunodeficiency syndrome Adolescent human immunodeficiency virus infection and gastrointestinal disease Effect of HIV co-infection on mutation patterns of HBV in patients with lamivudine-resistant chronic hepatitis Hepatitis B in HIV patients: What is the current treatment and what are the challenges? Diagnosis and management of hepatitis B virus and HIV coinfection Hepatitis C in patients with human immunodeficiency virus infection: diagnosis, natural history, meta-analysis of sexual and vertical transmission, and therapeutic issues Maternal-infant transmission of hepatitis C virus and HIV infections: A possible interaction Coinfection with HIV-1 and HCV -a one-two punch HIV and hepatitis C coinfection Protection against persistence of hepatitis C Later, in 1984, 4 HIV-1 was determined to be the causative agent, and HIV-1 infection was recognized as a spectrum of disease, ranging from asymptomatic infection to full-blown AIDS. keywords: aids; associated; bacterial; cd4; cells; children; chronic; diarrhea; disease; function; gastrointestinal; haart; hepatitis; hiv-1; human; immunodeficiency; infection; malabsorption; patients; studies; therapy; tract; treatment; virus cache: cord-022521-r72jtoso.txt plain text: cord-022521-r72jtoso.txt item: #447 of 2876 id: cord-022527-a0x6lws3 author: None title: Eosinophils in Human Disease date: 2012-10-12 words: 56098 flesch: 33 summary: Extending this study, Flood-Page et al. 74 evaluated anti-IL-5 monoclonal antibody treatment in asthma patients by examining its multidose effect on blood and sputum, as well as bone marrow and airway tissue eosinophils. As corticosteroid treatment reduced serum, sputum, and tissue eosinophils, and these reductions were associated with improved asthma symptoms, the eosinophil's place as a primary contributor to asthma appeared further substantiated. keywords: activation; acute; airway; allergen; anti; asthma; blood; blood eosinophils; bone; bronchial; cells; chronic; crs; cytokines; disease; ecp; eoe; eosinophils; epithelial; expression; factor; following; gene; group; growth; human; il-5; infection; infiltration; inflammation; inflammatory; levels; lung; marrow; mbp; nasal; numbers; patients; polyps; presence; present; production; protein; rejection; release; response; role; serum; skin; specific; sputum; sputum eosinophils; stent; studies; study; subjects; symptoms; syndrome; t cells; t h; therapy; tissue; tissue eosinophils; treatment; tumor; virus cache: cord-022527-a0x6lws3.txt plain text: cord-022527-a0x6lws3.txt item: #448 of 2876 id: cord-022594-fx044gcd author: Pirko, Istvan title: Demyelinating Disorders of the Central Nervous System date: 2009-05-18 words: 25150 flesch: 43 summary: Not only do several viral and bacterial peptides share structural similarities with MBP, but it has also been demonstrated that these antigens may activate MBP-specific T-cell clones derived from MS patients. Virus has rarely been cultured from CSF of MS patients, but a new strain of HSV (the MS strain) and a new virus (Inoue-Melnick virus) were first isolated from the CSF of MS patients. keywords: acute; adem; brain; cases; clinical; cns; cord; course; criteria; csf; demyelination; diagnosis; disability; disease; dose; evidence; interferon; lesions; matter; mri; ms patients; patients; rate; relapse; relapsing; risk; sclerosis; spinal; studies; study; symptoms; syndrome; treatment; trial; years cache: cord-022594-fx044gcd.txt plain text: cord-022594-fx044gcd.txt item: #449 of 2876 id: cord-022633-fr55uod6 author: None title: SAEM Abstracts, Plenary Session date: 2012-04-26 words: 147610 flesch: 49 summary: Objectives: To identify the prevalence of NCS and other EEG abnormalities in ED patients with AMS. Objectives: Test the hypothesis that prior to antibiotic administration, circulating LPS can be detected in the plasma of fewer than 10% of ED patients with severe sepsis. keywords: academic; acute; admission; adult ed; adult patients; age; analysis; arrest; arrest patients; assessment; association; average; background; blood; cardiac; care; cases; center; change; characteristics; chest; children; clinical; cohort; conclusion; confidence; control; cpr; criteria; data; days; department; diagnosis; difference; discharge; disease; ed care; ed patients; ed physicians; ed visits; eds; effect; emergency; emergency department; ems; evaluation; factors; following; group; health; high; hospital; hospital ed; hours; implementation; increase; information; initial; injury; inpatient; intervention; intubation; length; level; los; low; management; mean; median; medical; medicine; methods; minutes; model; months; mortality; n =; non; number; objectives; outcomes; overall; p =; pain; pain patients; participants; pediatric; performance; period; population; post; pre; prehospital; primary; prior; program; protocol; providers; quality; range; rate; regression; research; residency; residents; respectively; results; retrospective; review; risk; sample; score; screening; self; sepsis; setting; shock; standard; students; studies; study; study ed; subjects; survey; survival; system; table; test; testing; time; total; training; trauma patients; treatment; triage; urban; use; years cache: cord-022633-fr55uod6.txt plain text: cord-022633-fr55uod6.txt item: #450 of 2876 id: cord-022646-f7qs1obg author: Frey, Noelle V. title: Hematopoietic stem cell transplantation: ASBMT/CIBMTR 2010 tandem meeting highlights and discussion date: 2010-04-27 words: 21951 flesch: 47 summary: Sickle cell patients develop organ damage irrespective of their frequency of acute painful events, which has been related to significant morbidity and increased mortality, and it seems likely that SCD-related organ damage negatively impacts QoL of sickle cell patients [6] . These data suggest that frequent painful and unpredictable crises are an important psychological burden rather than a physical burden to sickle cell patients as has been suggested previously [12] . keywords: acute; analysis; cancer; care; cases; cell; chl; chronic; cml; damage; diagnosis; disease; expression; factor; gvhd; hoct1; hodgkin; leukemia; level; lines; lymphoma; mrna; mutation; patients; physicians; primary; qol; response; sct; study; survivors; survivorship; tp53; treatment; tumor cache: cord-022646-f7qs1obg.txt plain text: cord-022646-f7qs1obg.txt item: #451 of 2876 id: cord-022650-phsr10jp author: None title: Abstracts TPS date: 2018-08-14 words: 119916 flesch: 51 summary: Method: Postal questionnaires were distributed to an unselected group of asthma patients (n = 190). NHR was reported in 71% of asthma patients and 22% in non-asthmatic controls (P < 0.0001), with changes in temperature being the most important inducer of nasal symptoms (74% of asthmatics), followed by strong odours (62%) and cigarette smoke (61%). keywords: adults; age; aim; allergen; allergies; allergy; analysis; anaphylaxis; angioedema; anti; ara; asthma; asthma control; asthma patients; asthma symptoms; asthmatic; atopic; background; blood; case; cells; challenge; children; chronic; clinic; concentration; conclusion; control; control group; correlation; cross; data; days; dermatitis; diagnosis; differences; disease; dose; drug; dust; effect; efficacy; egg; episodes; exposure; extracts; factors; food; food allergy; grass; group; hae; high; history; hospital; hours; house; ige; ige levels; igg; immunotherapy; improvement; increase; levels; life; low; male; mean; median; medical; medication; method; milk; minutes; mite; months; nasal; non; number; p 1; p =; patients; peanut; period; pollen; pollen allergy; population; positive; present; prevalence; prick; protein; questionnaire; rate; reaction; reactivity; reduction; report; respiratory; response; results; rhinitis; rhinitis patients; risk; scit; score; sensitization; serum; severity; sige; skin; skin prick; slit; specific; spt; studies; study; subjects; symptoms; syndrome; test; testing; time; total; treatment; type; urticaria; use; weeks; years cache: cord-022650-phsr10jp.txt plain text: cord-022650-phsr10jp.txt item: #452 of 2876 id: cord-022653-qa1uph35 author: None title: Poster Discussion Session PDS date: 2017-08-30 words: 58403 flesch: 49 summary: Out of all maxillary sinuses (n=72) from study patients, 62 (86.11%) were opacified, and only these sinuses were included in further analyses. We studied three groups of subjects: peach allergic patients who received Prup3-enriched-SLIT for 1 year, peach allergic patients non treated, and healthy controls who tolerated peach. keywords: age; aim; allergen; allergic; allergy; analysis; anaphylaxis; anti; associated; asthma; asthma patients; atopic; blood; cases; cells; changes; children; conclusions; control; correlation; data; diagnosis; differences; disease; dose; drug; effect; exposure; expression; food; food allergy; group; hdm; healthy; history; ige; ige levels; immune; immunotherapy; increase; inflammation; introduction; levels; low; mean; methods; mice; milk; months; nasal; non; number; objectives; patients; period; pollen; production; protein; reactions; reactivity; response; results; rhinitis; risk; samples; score; sensitization; serum; skin; slit; specific; studies; study; subjects; symptoms; test; therapy; time; total; treatment; use; years cache: cord-022653-qa1uph35.txt plain text: cord-022653-qa1uph35.txt item: #453 of 2876 id: cord-022658-mq91h15t author: None title: Executive summary date: 2008-12-30 words: 12010 flesch: 33 summary: Evidence of minimal, persistent inflammation in asymptomatic allergic patients suggests that by inducing ICAM-1, subclinical allergen exposure may incregse the susceptibility of allergic patients to rhinovirus infection, and thereby explain the greater frequency of colds in asthmatic children (30) . Although the use of antihistamines in asthma is still controversial, the new nonsedating agents seem to offer some benefit for allergic patients with concomitant asthma. keywords: agents; airway; allergy; antihistamines; asthma; children; chronic; control; effects; intranasal; loratadine; medications; nasal; patients; performance; rhinitis; symptoms; therapy; topical; treatment; use cache: cord-022658-mq91h15t.txt plain text: cord-022658-mq91h15t.txt item: #454 of 2876 id: cord-022659-chwk2bs4 author: None title: Abstracts: Poster session date: 2004-10-08 words: 49293 flesch: 47 summary: We conclude that this cingulate activation may reflect the greater involvement of an attentional network (of which the anterior cingulate is a part) in tasks requiring a higher degree of mental work on the part of AD patients. To investigate erythrocyte membrane molecular dynamics in AD patients and age-matched controls, we investigated erythrocyte membrane molecular motion at the surface (fluorescamine), aqueous-hydrocarbon interface (DPPE-ANS), and hydrocarbon core (1219j-AS; PPC-DPH) by steady-state fluorescence anisotropy measurements of 16 probable AD patients (5 males; 11 females) and 20 (1 1 males; 9 females) age-matched controls. keywords: activation; activity; acute; ad patients; age; als; alzheimer; analysis; antibodies; blood; brain; cases; cells; cerebral; changes; chronic; conduction; controls; criteria; csf; data; days; dementia; diagnosis; disease; dose; effects; evidence; examination; factors; findings; function; group; hours; human; improvement; infection; injury; left; lesions; levels; loss; mean; memory; months; motor; mri; muscle; myelin; nerve; neurological; onset; p =; parkinson; patients; pd patients; present; protein; response; results; risk; scale; sclerosis; scores; sensory; serum; severity; specific; spinal; stroke; studies; study; subjects; symptoms; syndrome; test; treatment; type; women; years cache: cord-022659-chwk2bs4.txt plain text: cord-022659-chwk2bs4.txt item: #455 of 2876 id: cord-022888-dnsdg04n author: None title: Poster Sessions date: 2009-08-19 words: 189173 flesch: 41 summary: Our aim is to describe how B cell lymphoma cells respond to TGF-b compared to normal peripheral B cells, to create an overview of the different signaling pathways involved, and to characterize the mechanisms behind the loss of sensitivity to TGF-b. Methods: Proliferation assays were performed on 11 different B-cell lymphoma cell lines and normal peripheral B cells to screen for TGF-b-induced effects. Using a CD3 and CD28 activation model system -TLR4 presence on CD4+ cells is found in mouse T cells, human T cells and Jurkat cell lines. keywords: + cells; ability; absence; activity; addition; analysis; antibodies; antibody; antigen; apoptosis; apoptotic; assay; associated; autoimmune; b cells; b t; binding; blood; bone; c mice; cancer cells; capacity; cd4; cd8 +; cd8 cells; cd8 t; cell activation; cell activity; cell culture; cell cycle; cell death; cell development; cell differentiation; cell epitopes; cell function; cell level; cell lines; cell membrane; cell population; cell proliferation; cell receptor; cell responses; cell subsets; cell surface; cell tolerance; cell types; cells cells; changes; chronic; class; clinical; colitis; complex; conclusion; contrast; control; control cells; cross; ctl; cytokine; cytokine production; cytometry; cytotoxic t; data; day; days; dcs; deficient; delta t; dendritic; disease; dna; early; effector cells; effector t; effects; elisa; expansion; experiments; expression; expression levels; factor; family; findings; flow; following; formation; function; gamma; gd cells; gd t; gene; gene expression; group; high; hiv; hla; host; human; ifn; ifng; igg; il-10; il-2; il-4; il-6; immune; immunity; increase; independent; induction; infected; infection; inflammation; inflammatory; inhibition; inkt; interaction; intracellular; levels; lps; macrophages; major; marrow cells; mast cells; mechanisms; membrane; memory t; methods; mhc; mice; model; molecules; monocytes; mouse; mouse t; mrna; murine; negative; neutrophils; new; nkt cells; non; normal; novel; number; objectives; pathway; patients; pcr; peptide; peripheral; plasma cells; play; positive; potential; presence; presentation; primary; production; promoter; protein; protein expression; receptors; regulation; regulatory; release; results; role; secretion; serum; signaling; skin; sle; specific; spleen; stem cells; stimulation; studies; study; surface expression; system; t cells; t em; t h; t helper; t lymphocytes; target cells; tcr; test; th1 cells; time; tissue; tlr; tnf; tolerance; transcription; treatment; tumor cells; type; university; vaccination; vaccine; vg9vd2 t; virus; vitro; vivo; work cache: cord-022888-dnsdg04n.txt plain text: cord-022888-dnsdg04n.txt item: #456 of 2876 id: cord-022940-atbjwpo5 author: None title: Poster Sessions date: 2016-09-07 words: 241687 flesch: 44 summary: Among used cancer cell lines, ERICD was highly expressed and ARID3A had lower expression in U-2OS (osteosarcoma), A-172 (glioblastoma) and A549 (lung cancer). Clear cell renal cell cancer (ccRCC) with metastases has pour prognosis: 5-year survival is about 9%. keywords: a549 cells; acid; activation; activities; activity; activity levels; acute; addition; administration; affinity; agents; aim; albumin; allele; alterations; alternative; amino; analysis; analysis results; animals; ankara; anti; antibodies; antibody; anticancer; antioxidant; apoptosis; applications; approach; assay; association; bacteria; beta; binding; biology; blood; body; bone; brain; breast cancer; cancer cells; cancer group; cancer patients; cancer stem; cancer treatment; cancers; cause; cell cycle; cell death; cell growth; cell lines; cell proliferation; cell survival; cell viability; changes; characterization; chemical; cholesterol; chronic; clinical; coli; colorectal; combination; comparison; complex; complexes; compounds; concentrations; conclusion; conditions; content; control cells; control group; control study; controls; correlation; culture; curcumin; current; cytotoxic; damage; data; day; days; decrease; department; detection; determination; development; diabetes; differences; differentiation; discussion; disease; dna; domain; dose; drug; effects; elevated; elisa; energy; enzyme; enzyme activity; ethanol; experimental; expression analysis; expression levels; expressions; extract; factor; faculty; family; fat; findings; flow; fluorescence; fold; food; formation; free; function; gene expression; genes; genetic; genome; genotype; glucose; glutathione; group; growth; gsh; health; hours; human; immune; increase; inflammation; inflammatory; inhibition; inhibitors; injury; institute; insulin; interaction; intracellular; introduction; invasion; investigation; ischemia; kinase; laboratory; lead; levels; light; like; lipid; liver; low; lung; male; manner; markers; mass; materials; matrix; mcf-7; mda; mda levels; mean; mechanisms; medical; medicine; medium; membrane; metabolism; methods; methylation; mice; microscopy; migration; mirnas; mitochondrial; model; modified; molecular; molecules; mrna; muscle; mutant; mutations; n =; nanoparticles; negative; non; normal; novel; number; obese; obesity; oil; order; oxidative; oxygen; p =; p-02.08.5; parameters; pathway; patients; pcr; peptide; phase; plant; plasma; play; point; polymorphisms; population; potential; presence; present; process; processes; production; products; profile; progression; promoter; properties; prostate; prostate cancer; protective; protein; protein expression; protein levels; purpose; radical; range; rate; rats; reaction; receptor; recombinant; region; regulation; related; relationship; research; resistance; response; results; risk; role; samples; science; scientific; screening; sequence; serum; serum levels; signaling; site; size; sod; species; specific; stability; stage; status; stem cells; strain; stress; structure; studies; study; study group; subjects; surface; survival; synthesis; system; target; technique; temperature; test; tested; therapeutic; therapy; time; tissue; tnf; total; transcription; treatment; treatment group; tumor; tumor cells; turkey; type; university; use; values; vitamin; vitro; water; weight; western; wild; women; work; years cache: cord-022940-atbjwpo5.txt plain text: cord-022940-atbjwpo5.txt item: #457 of 2876 id: cord-023017-k6edtg58 author: None title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 words: 65964 flesch: 47 summary: The aim of the present study was to investigate if the same inhibition takes place in livers cells of patients with chronic hepatitis C. From February 2001 to April 2002, all patients with chronic hepatitis C referred to the outpatient liver clinic of the University Hospital Basel were asked for their permission to use part of the liver biopsy for this study. Increased T cell activation with Eta may also suggest that TNFA suppress T cell function and may contribute to refractoriness to INF therapy in HCV patients. keywords: -no; activation; activity; addition; age; alpha; alt; analysis; anti; biopsies; biopsy; blood; cases; cd8; cells; chronic; chronic hcv; chronic hepatitis; cirrhosis; combination; conclusions; control; core; culture; data; days; dcs; different; disease; dose; effect; expression; factors; fibrosis; gene; genotype; group; hcc; hcv; hcv genotype; hcv infection; hcv patients; hcv rna; hepatic; hepatitis; hepatocytes; hsc; human; ifn; infection; interferon; levels; liver; mean; meld; methods; mice; months; negative; non; ns3; patients; pcr; population; positive; protein; rats; rejection; relationships; response; results; ribavirin; risk; role; serum; specific; steatosis; stem; studies; study; subjects; survival; system; t cells; therapy; time; total; transplantation; treated; treatment; virus; weeks; years cache: cord-023017-k6edtg58.txt plain text: cord-023017-k6edtg58.txt item: #458 of 2876 id: cord-023033-tgt69ir6 author: None title: Poster Session (pp. 78A–178A) date: 2006-02-10 words: 16164 flesch: 41 summary: Moreover, they support the hypothesis that experimental forcing of exogenous antigens into the MHC class I pathway and subsequent promotion of cross-priming is particularly important to generate T cell responses against noncytopathic and tissue tropic viruses such as HCV. For further characterization of T cell epitopes HCV specific T cell clones were generated from 6 patients against eight different HCV epitopes located within the NS3 (aa1027-1657, two epi-topes) and NS4alb (aa1658-1972, six epitopes) region. keywords: -no; anti; bile; cd4; cd8; cells; control; expression; group; hcv; hepatitis; hepatocytes; ifn; increased; ldlt; levels; liver; methods; mice; model; patients; positive; protein; rats; relationships; responses; results; serum; specific; survival; t cells; transplantation; transplanted; treatment cache: cord-023033-tgt69ir6.txt plain text: cord-023033-tgt69ir6.txt item: #459 of 2876 id: cord-023049-fio7cjj5 author: None title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 words: 145714 flesch: 46 summary: We compared the median SNAP with radial SNAP measured antidromically at digit 1 in GBS patients whose nerve conduction study showed the sural-sparing pattern. The aim of the present investigation is to summarize the current knowledge on sweating disturbances in GBS patients. keywords: 1,2; activity; acute; addition; age; aim; amyloid; analysis; anti; antibodies; antibody; associated; axonal; axons; barré; baseline; biopsy; blood; cases; cause; cells; center; changes; charcot; children; chronic; cidp patients; cmt patients; cmt1a; cohort; conduction study; control patients; controls; course; criteria; data; days; degeneration; demyelinating; department; development; diabetic; diagnosis; differences; disability; disease; dominant; dose; effect; examination; expression; f 1; family; findings; following; foot; france; function; g 1; gbs patients; gene; group; guillain; healthy; hospital; human; igg; impairment; improvement; increase; inflammatory; injury; institute; intravenous; involvement; ivig; j 1; k 1; levels; limbs; loss; mag; marie; mean; measures; median; medical; medicine; mice; model; months; motor; motor nerve; mouse; mri; muscle; mutations; ncs; negative; nerve; nerve conduction; nerve fibers; nerve injury; nerve regeneration; neurological; neurology; neurons; neuropathies; neuropathy; new; nf155; non; normal; novel; number; onset; outcome; pain; participants; patients; phenotype; placebo; pmp22; polyneuropathy; positive; potential; present; progression; protein; range; reduced; report; respectively; response; results; risk; role; scale; schwann; score; sensory; sequencing; serum; severe; severity; skin; strength; studies; study; subjects; sural; symptoms; syndrome; system; test; testing; therapeutic; therapy; time; tissue; tooth; total; treatment; ttr; type; ulnar; university; upper; usa; variants; weakness; weeks; y 1; years cache: cord-023049-fio7cjj5.txt plain text: cord-023049-fio7cjj5.txt item: #460 of 2876 id: cord-023157-0lqlx2rv author: None title: Poster Sessions date: 2013-04-18 words: 128609 flesch: 50 summary: Results: Mean values of WC, blood pressure (BP), fasting plasma glucose (FPG), triglycerides (TG), HDL-Cholesterol and BMI were significantly higher in men than in women who had higher %BF (28% vs. 21%). Results: During IvGTT GBP-pigs displayed lower glucose and higher insulin levels compared to controls. keywords: 0.001; acid; activity; adiponectin; adipose; age; aim; analysis; association; background; baseline; blood; blood glucose; blood pressure; bmi; body; body weight; cardiovascular; changes; children; cholesterol; circumference; clinical; conclusion; control; control group; correlation; criteria; crp; data; day; decrease; development; diabetes; diabetes mellitus; diet; disease; dm patients; effect; expression; factors; fasting; fat; females; gene; glucose; glucose levels; glucose tolerance; group; hba1c; hdl; health; homa; hypertension; increase; index; individuals; insulin; insulin levels; insulin resistance; insulin sensitivity; intake; leptin; levels; lipid; liver; low; markers; mass; mean; metabolic; methods; mets; mice; mmol; model; months; n =; non; normal; obese; obesity; objective; overweight; oxidative; p =; parameters; participants; patients; plasma; plasma glucose; population; pressure; prevalence; profile; protein; r =; rate; ratio; rats; reduction; results; risk; risk factors; role; sensitivity; serum; stress; study; study group; subjects; syndrome; test; time; tissue; total; treatment; triglycerides; type; university; values; vs.; waist; weeks; weight; women; years cache: cord-023157-0lqlx2rv.txt plain text: cord-023157-0lqlx2rv.txt item: #461 of 2876 id: cord-023168-cd7adns8 author: Thachil, Jecko title: Haematological Diseases in the Tropics date: 2013-10-21 words: 30246 flesch: 37 summary: WHD/3 Information sheet for clinicians Development and evaluation of a new paediatric blood transfusion protocol for Africa Electrocardiographic ST-segment changes during acute, severe isovolemic hemodilution in humans Use of clinical judgement to guide administration of blood transfusions in Malawi Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation Autologous transfusion techniques: a systematic review of their efficacy Intraoperative autologous blood management Artificial O2 carriers: status in 2005 Red blood cell transfusions in acute paediatrics Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi Intermittent preventive therapy for malaria with monthly artemether-lumefantrine for the post-discharge management of severe anaemia in children aged 4-59 months in southern Malawi: a multicentre, randomised, placebocontrolled trial Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital Bacterial contamination of blood and blood components in three major blood transfusion centres in Accra, Ghana Access the complete references online at www.expertconsult.com Causes and outcomes of the acute chest syndrome in sickle cell disease The acute chest syndrome in sickle cell disease: incidence and risk factors Acute chest syndrome in sickle-cell disease Bronchoalveolar lavage in adult sickle cell patients with acute chest syndrome: value for diagnostic assessment of fat embolism Secretory phospholipase A(2) predicts impending acute chest syndrome in sickle cell disease Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vasoocclusive crisis or acute chest syndrome Cerebrovascular accidents in sickle cell disease: rates and risk factors Pathophysiology and treatment of stroke in sicklecell disease: Present and future Lesion burden and cognitive morbidity in children with sickle cell disease Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: A report from the Cooperative Study of Sickle Cell Disease Nocturnal hypoxaemia and central-nervoussystem events in sickle-cell disease Natural history of blood pressure in sickle cell disease: Risks for stroke and death associated with relative hypertension in sickle cell anemia Prophylaxis with oral penicillin in children with sickle cell anemia. keywords: acute; anaemia; bleeding; blood; blood transfusion; bone; cause; cell; cell disease; children; chronic; complications; countries; deficiency; diagnosis; disease; factor; folate; g6pd; haemoglobin; haemolysis; hiv; individuals; infections; iron; iron deficiency; levels; lymphoma; major; malaria; management; marrow; patients; platelet; prevalence; risk; scd; syndrome; thalassaemia; therapy; thrombocytopenia; transfusion; treatment; vitamin; years cache: cord-023168-cd7adns8.txt plain text: cord-023168-cd7adns8.txt item: #462 of 2876 id: cord-023169-obupqcua author: Chierakul, Wirongrong title: Leptospirosis date: 2013-10-21 words: 4985 flesch: 39 summary: using a new solid medium, LVW agar Antibiotic prophylaxis for leptospirosis A century of Leptospira strain typing Genome reduction in Leptospira borgpetersenii reflects limited transmission potential Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control study A waterborne outbreak of leptospirosis An institutional outbreak of leptospirosis in Chennai, South India Human-to-human transmission of Leptospira interrogans by milk The globalization of leptospirosis: worldwide incidence trends Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world Report of the second meeting of the leptospirosis burden epidemiology reference group Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen In vitro evidence for immune evasion activity by human plasmin associated to pathogenic Leptospira interrogans Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism New insights into the pathogenicity of leptospires: evasion of host defences Liver biopsy in human leptospirosis: a light and electron microscopy study Kidney biopsies in human leptospirosis: a biochemical and electron microscopy study Acute kidney injury in human leptospirosis: an immunohistochemical study with pathophysiological correlation Immunohistochemical and in situ hybridization studies of the liver and kidney in human leptospirosis Activation of the coagulation cascade in patients with leptospirosis Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia Melbourne: MediSci Factors associated with clinical leptospirosis: a populationbased case-control study in the Seychelles (Indian Ocean) Severe leptospirosis is a multi-system disease. keywords: acute; cases; disease; haemorrhage; human; illness; jaundice; leptospira; leptospirosis; pathogenic; patients; serovar cache: cord-023169-obupqcua.txt plain text: cord-023169-obupqcua.txt item: #463 of 2876 id: cord-023186-gqltd6u0 author: None title: Poster Sessions date: 2019-06-27 words: 14394 flesch: 52 summary: In addition, the group with a negative slope of FEV1% predicted change during the first 3 months had a higher likelihood of O2 therapy, compared to the group with a positive slope of FEV1 change during the period (HR of 3.57, P = 0.059). However, there was no significant difference in the change over 3 months of FEV1% predicted values between the two groups at 6, 9, and 12 months. keywords: age; asthma; cases; children; days; difference; flow; group; hospital; infants; lung; months; oxygen; patients; pneumonia; rate; results; score; stay; study; therapy; total; treatment; years cache: cord-023186-gqltd6u0.txt plain text: cord-023186-gqltd6u0.txt item: #464 of 2876 id: cord-023211-kt5gt26t author: None title: Poster Session Abstracts date: 2007-08-29 words: 221712 flesch: 48 summary: Understanding how its modulation modifies transepithelial transport and inflammation in CF versus non CF cells should give new therapeutic clues to reduce exaggerated inflammation and improve fluid secretion in CF patients. This finding indicates that CFTR potentiators have a wide efficacy on many class III mutants and therefore may represent a promising therapeutic strategy for a significant number of CF patients. keywords: acid; addition; adult cf; adult patients; adults; aeruginosa; age; aim; airway; airway cells; amiloride; analysis; antibiotic; asl; assay; atp; background; bacterial; baseline; binding; biofilm; blood; bmi; cells; cf airways; cf care; cf center; cf clinic; cf foundation; cf gene; cf group; cf lung; cf mouse; cf nbs; cf patients; cf research; cf sputum; cff; cfrd; cftr; cftr activation; cftr activity; cftr cells; cftr channel; cftr chloride; cftr expression; cftr function; cftr gene; cftr inhibitor; cftr mice; cftr mutations; cftr promoter; cftr protein; cftr trafficking; changes; channel; children; chronic; clearance; clinical; concentrations; conclusion; conditions; contrast; control; cultures; current; cystic; daily; data; day; days; decline; decreased; dependent; diabetes; differences; disease; dna; domain; dose; drug; effect; enac; epithelial; exacerbation; experiments; exposure; expressing; f508del; factors; family; fev1; fibrosis patients; findings; fold; forskolin; functional; genes; glands; group; growth; health; hospital; hours; human; human cf; il-8; improvement; increase; individuals; infants; infection; inflammation; inflammatory; information; inhibited; inhibition; isolates; levels; life; low; lung cells; lung disease; lung function; lungs; mean; measure; mechanism; median; medical; membrane; methods; mice; model; months; mrsa; mucus; mutant; nasal; nbd1; neutrophil; new; non; normal; novel; number; observed; order; pancreatic; parents; pathway; patients age; pcr; pediatric; period; plasma; population; positive; post; potential; presence; present; production; proteins; pseudomonas; pulmonary; quality; range; rate; regulation; research; respiratory; response; results; risk; role; samples; scores; screening; secretion; sensitive; serum; specific; status; stimulation; strains; studies; study; study patients; subjects; support; surface; symptoms; system; test; testing; therapeutic; therapies; therapy; time; tobramycin; total; transport; treatment; type cftr; university; usa; use; values; vitamin; vitro; vivo; volume; weight; wt cells; wt cftr; years; ∆f508 cftr cache: cord-023211-kt5gt26t.txt plain text: cord-023211-kt5gt26t.txt item: #465 of 2876 id: cord-023216-avn8f2w3 author: None title: Symposium summaries date: 2004-10-18 words: 55740 flesch: 41 summary: The existence of an underlying defect in the airway immune response of CF patients remains controversial; however, increasing evidence suggests that the CF lung exhibits an exaggerated immune response even in the absence of bacterial infection (1;2). In CF patients with mild disease, compared with age-matched normal subjects, a reduced mucociliary clearance has been reported (4). keywords: activity; age; airway; analysis; atp; binding; bone; care; cells; center; cf care; cf lung; cftr; cftr function; cftr protein; channel; children; chloride; chronic; clearance; control; cystic; data; diabetes; diagnosis; disease; early; expression; factors; fibrosis; function; gene; genetic; glucose; human; infection; inflammation; insulin; kinase; levels; life; liver; liver disease; lung; lung disease; mice; mucus; mutations; newborn; non; pain; patients; potential; protein; respiratory; response; results; role; screening; secretion; specific; studies; study; surface; sweat; therapy; time; transport; treatment; type; use; years cache: cord-023216-avn8f2w3.txt plain text: cord-023216-avn8f2w3.txt item: #466 of 2876 id: cord-023239-06a03o14 author: None title: II. Topic Sessions date: 2016-06-10 words: 33484 flesch: 34 summary: Several studies reported an association of preterm birth (30-36 weeks' GA) without clinical lung disease with altered lung development and function [2] . The Size and Lung function In Children (SLIC) study was designed to improve normative reference ranges for lung function by taking differences in body physique into account to facilitate early diagnosis and treatment of lung disease in all children, irrespective of ethnic background 7 . keywords: age; airway; approach; asthma; birth; bronchiectasis; cells; cftr; childhood; children; chronic; control; cystic; data; diagnosis; disease; effect; evidence; exacerbations; factors; fibrosis; function; infants; lung; lung disease; lung function; need; non; osas; patients; pcd; pneumonia; preschool; preterm; receptors; respiratory; results; risk; sleep; studies; study; symptoms; term; therapy; treatment; use; years cache: cord-023239-06a03o14.txt plain text: cord-023239-06a03o14.txt item: #467 of 2876 id: cord-023288-sqr33y72 author: None title: Paediatric SIG: Poster Session date: 2008-03-12 words: 30188 flesch: 50 summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients. keywords: age; aim; airway; analysis; asm; asthma; asthmatics; blood; cancer; cells; children; conclusions; control; copd; data; days; disease; effect; expression; fev1; flow; function; group; health; il-6; increase; infection; inflammatory; levels; lung; mean; methods; mice; n =; non; p =; participants; patients; pulmonary; response; results; risk; smokers; study; subjects; therapy; treatment; use; years cache: cord-023288-sqr33y72.txt plain text: cord-023288-sqr33y72.txt item: #468 of 2876 id: cord-023298-ysur3sjq author: None title: Respiratory Nurses SIG: Poster Session date: 2011-03-21 words: 32066 flesch: 52 summary: Results mRNA stability studies indicated that B 1 R SV was ≈35% less stable than the WT transcript in H2126 cells suggesting a stabilizing element 5'UTR. Lower fi bre intake in asthmatic subjects (n = 124) was associated with lower %predicted FEV 1 (r = 0.41, p = 0.004), %FVC (r = 0.43, p = 0.015) and FEV 1 /FVC keywords: acute; age; aim; airway; asm; asthma; cells; children; conclusions; confl; control; copd; cough; data; days; disease; expression; function; group; hospital; hrv; ict; identifi; infection; infl; interest; levels; lung; mean; methods; months; n =; non; p =; patients; post; pulmonary; range; respiratory; results; signifi; studies; study; subjects; symptoms; time; treatment; use; years cache: cord-023298-ysur3sjq.txt plain text: cord-023298-ysur3sjq.txt item: #469 of 2876 id: cord-023302-p9pxz44a author: None title: Cystic Fibrosis SIG: Poster Session date: 2011-03-21 words: 32066 flesch: 52 summary: Results mRNA stability studies indicated that B 1 R SV was ≈35% less stable than the WT transcript in H2126 cells suggesting a stabilizing element 5'UTR. Lower fi bre intake in asthmatic subjects (n = 124) was associated with lower %predicted FEV 1 (r = 0.41, p = 0.004), %FVC (r = 0.43, p = 0.015) and FEV 1 /FVC keywords: acute; age; aim; airway; asm; asthma; cells; children; conclusions; confl; control; copd; cough; data; days; disease; expression; function; group; hospital; hrv; ict; identifi; infection; infl; interest; levels; lung; mean; methods; months; n =; non; p =; patients; post; pulmonary; range; respiratory; results; signifi; studies; study; subjects; symptoms; time; treatment; use; years cache: cord-023302-p9pxz44a.txt plain text: cord-023302-p9pxz44a.txt item: #470 of 2876 id: cord-023303-fxus38mp author: None title: Lung Cancer/Bronchology SIGs: Combined Poster Session date: 2008-03-12 words: 30191 flesch: 50 summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients. keywords: age; aim; airway; analysis; asm; asthma; asthmatics; blood; cancer; cells; children; conclusions; control; copd; data; days; disease; effect; expression; fev1; flow; function; group; health; il-6; increase; infection; inflammatory; levels; lung; mean; methods; mice; n =; non; p =; participants; patients; pulmonary; response; results; risk; smokers; study; subjects; therapy; treatment; use; years cache: cord-023303-fxus38mp.txt plain text: cord-023303-fxus38mp.txt item: #471 of 2876 id: cord-023305-5lb9kho6 author: None title: Oliv SIG: Poster Session date: 2011-03-21 words: 32065 flesch: 52 summary: Results mRNA stability studies indicated that B 1 R SV was ≈35% less stable than the WT transcript in H2126 cells suggesting a stabilizing element 5'UTR. Lower fi bre intake in asthmatic subjects (n = 124) was associated with lower %predicted FEV 1 (r = 0.41, p = 0.004), %FVC (r = 0.43, p = 0.015) and FEV 1 /FVC keywords: acute; age; aim; airway; asm; asthma; cells; children; conclusions; confl; control; copd; cough; data; days; disease; expression; function; group; hospital; hrv; ict; identifi; infection; infl; interest; levels; lung; mean; methods; months; n =; non; p =; patients; post; pulmonary; range; respiratory; results; signifi; studies; study; subjects; symptoms; time; treatment; use; years cache: cord-023305-5lb9kho6.txt plain text: cord-023305-5lb9kho6.txt item: #472 of 2876 id: cord-023306-3gdfo6vd author: None title: TSANZ Oral Abstracts date: 2010-03-01 words: 23408 flesch: 50 summary: This prospective study confirms the risk status assigned by the LCSS with 41 (6%) vs. 11 (2%) lung cancers over the 5 year follow up (OR = 2.6 (%% CI 1.3-5.4, p = 0.005).The performance characteristics of the LCSS reported here, confirm its utility, in correctly identifying smokers at greatest lung cancer risk. In the Indigenous Australian setting the SGRQ total score was independently associated with exacerbation frequency and lung function (% predicted FEV1) whilst the symptom score was associated more strongly with AE frequency and activity score with lung function. keywords: age; aim; airway; asthma; australia; cells; children; conclusion; control; copd; data; days; disease; exercise; expression; function; group; il-6; introduction; levels; lung; mean; methods; months; n =; non; patients; post; pulmonary; reduced; respiratory; response; results; risk; study; subjects; treatment; years cache: cord-023306-3gdfo6vd.txt plain text: cord-023306-3gdfo6vd.txt item: #473 of 2876 id: cord-023308-af5nihyi author: None title: COPD SIG: Poster Session 2 date: 2008-03-12 words: 30189 flesch: 50 summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients. keywords: age; aim; airway; analysis; asm; asthma; asthmatics; blood; cancer; cells; children; conclusions; control; copd; data; days; disease; effect; expression; fev1; flow; function; group; health; il-6; increase; infection; inflammatory; levels; lung; mean; methods; mice; n =; non; p =; participants; patients; pulmonary; response; results; risk; smokers; study; subjects; therapy; treatment; use; years cache: cord-023308-af5nihyi.txt plain text: cord-023308-af5nihyi.txt item: #474 of 2876 id: cord-023311-7wqdlha4 author: None title: Oral Session date: 2010-11-24 words: 17283 flesch: 47 summary: Conclusion Depression and anxiety were also found in lung cancer patients and need further evaluation and attention from clinician. Methods Patients with medically inoperable or unresectable single nodule NSCLC underwent treatments, in 3 different centers of Bangladesh. keywords: age; airway; asthma; children; conclusion; copd; data; day; diagnosis; disease; group; hospital; infl; introduction; lung; mean; methods; months; mortality; patients; pneumonia; pulmonary; respiratory; results; signifi; sputum; study; total; treatment; tuberculosis; years cache: cord-023311-7wqdlha4.txt plain text: cord-023311-7wqdlha4.txt item: #475 of 2876 id: cord-023314-rwjxk8v4 author: None title: Asthma & Allergy SIG: Poster Session 1 date: 2011-03-21 words: 32067 flesch: 52 summary: Results mRNA stability studies indicated that B 1 R SV was ≈35% less stable than the WT transcript in H2126 cells suggesting a stabilizing element 5'UTR. Lower fi bre intake in asthmatic subjects (n = 124) was associated with lower %predicted FEV 1 (r = 0.41, p = 0.004), %FVC (r = 0.43, p = 0.015) and FEV 1 /FVC keywords: acute; age; aim; airway; asm; asthma; cells; children; conclusions; confl; control; copd; cough; data; days; disease; expression; function; group; hospital; hrv; ict; identifi; infection; infl; interest; levels; lung; mean; methods; months; n =; non; p =; patients; post; pulmonary; range; respiratory; results; signifi; studies; study; subjects; symptoms; time; treatment; use; years cache: cord-023314-rwjxk8v4.txt plain text: cord-023314-rwjxk8v4.txt item: #476 of 2876 id: cord-023331-jrvmgnu3 author: None title: Asthma & Allergy SIG: Poster Session 3. Physiology, Environment, Investigation and Management date: 2008-03-12 words: 30195 flesch: 50 summary: Conclusions This is the first Australian study to identify alexithymia among asthma patients and investigate relationship to control as well as management and communication. Methods Cross sectional study of 25 moderate to severe asthma patients recruited from Royal Adelaide Hospital Outpatients. keywords: age; aim; airway; analysis; asm; asthma; asthmatics; blood; cancer; cells; children; conclusions; control; copd; data; days; disease; effect; expression; fev1; flow; function; group; health; il-6; increase; infection; inflammatory; levels; lung; mean; methods; mice; n =; non; p =; participants; patients; pulmonary; response; results; risk; smokers; study; subjects; therapy; treatment; use; years cache: cord-023331-jrvmgnu3.txt plain text: cord-023331-jrvmgnu3.txt item: #477 of 2876 id: cord-023333-b7w9zrl6 author: None title: Oeld/Population Health SIG: Poster Session date: 2011-03-21 words: 32067 flesch: 52 summary: Results mRNA stability studies indicated that B 1 R SV was ≈35% less stable than the WT transcript in H2126 cells suggesting a stabilizing element 5'UTR. Lower fi bre intake in asthmatic subjects (n = 124) was associated with lower %predicted FEV 1 (r = 0.41, p = 0.004), %FVC (r = 0.43, p = 0.015) and FEV 1 /FVC keywords: acute; age; aim; airway; asm; asthma; cells; children; conclusions; confl; control; copd; cough; data; days; disease; expression; function; group; hospital; hrv; ict; identifi; infection; infl; interest; levels; lung; mean; methods; months; n =; non; p =; patients; post; pulmonary; range; respiratory; results; signifi; studies; study; subjects; symptoms; time; treatment; use; years cache: cord-023333-b7w9zrl6.txt plain text: cord-023333-b7w9zrl6.txt item: #478 of 2876 id: cord-023343-y17z9w2x author: None title: COPD SIG: Poster Session 1 date: 2011-03-21 words: 32066 flesch: 52 summary: Results mRNA stability studies indicated that B 1 R SV was ≈35% less stable than the WT transcript in H2126 cells suggesting a stabilizing element 5'UTR. Lower fi bre intake in asthmatic subjects (n = 124) was associated with lower %predicted FEV 1 (r = 0.41, p = 0.004), %FVC (r = 0.43, p = 0.015) and FEV 1 /FVC keywords: acute; age; aim; airway; asm; asthma; cells; children; conclusions; confl; control; copd; cough; data; days; disease; expression; function; group; hospital; hrv; ict; identifi; infection; infl; interest; levels; lung; mean; methods; months; n =; non; p =; patients; post; pulmonary; range; respiratory; results; signifi; studies; study; subjects; symptoms; time; treatment; use; years cache: cord-023343-y17z9w2x.txt plain text: cord-023343-y17z9w2x.txt item: #479 of 2876 id: cord-023346-8sqbqjm1 author: None title: MONDAY: POSTERS date: 2005-06-08 words: 130150 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: aim; analysis; anti; antibodies; antibody; antigens; apheresis; assay; associated; background; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood donation; blood donors; blood establishments; blood group; blood loss; blood plasma; blood pressure; blood products; blood safety; blood samples; blood service; blood supply; blood system; blood transfusion; blood units; blood volume; cases; clinical; complications; concentrates; conclusion; control; cord blood; count; data; day; days; detection; disease; dna; donations; effect; events; factor; ffp; following; frequency; general; groups; hbsag; hbv; hcv; health; high; hla; hospital; hospital blood; identification; important; increase; infections; information; introduction; iron; laboratory; level; low; major; management; mean; medical; methods; national; negative; new; non; number; order; patients; pcr; period; plasma; platelet; platelet transfusion; population; positive; post; practice; presence; present; procedure; process; quality; range; rbc; rbc transfusion; rbcs; red; results; rhd; risk; routine; screening; serum; specific; standard; storage; studies; study; surgery; system; table; test; tested; testing; therapy; time blood; total; transfusion medicine; transfusion reactions; transfusion service; transfusion therapy; transfusions; treatment; type; use; weak; women; years cache: cord-023346-8sqbqjm1.txt plain text: cord-023346-8sqbqjm1.txt item: #480 of 2876 id: cord-023354-f2ciho6o author: None title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 words: 130154 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: aim; analysis; anti; antibodies; antibody; antigens; apheresis; assay; associated; background; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood donation; blood donors; blood establishments; blood group; blood loss; blood plasma; blood pressure; blood products; blood safety; blood samples; blood service; blood supply; blood system; blood transfusion; blood units; blood volume; cases; clinical; complications; concentrates; conclusion; control; cord blood; count; data; day; days; detection; disease; dna; donations; effect; events; factor; ffp; following; frequency; general; groups; hbsag; hbv; hcv; health; high; hla; hospital; hospital blood; identification; important; increase; infections; information; introduction; iron; laboratory; level; low; major; management; mean; medical; methods; national; negative; new; non; number; order; patients; pcr; period; plasma; platelet; platelet transfusion; population; positive; post; practice; presence; present; procedure; process; quality; range; rbc; rbc transfusion; rbcs; red; results; rhd; risk; routine; screening; serum; specific; standard; storage; studies; study; surgery; system; table; test; tested; testing; therapy; time blood; total; transfusion medicine; transfusion reactions; transfusion service; transfusion therapy; transfusions; treatment; type; use; weak; women; years cache: cord-023354-f2ciho6o.txt plain text: cord-023354-f2ciho6o.txt item: #481 of 2876 id: cord-023364-ut56gczm author: None title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 words: 130157 flesch: 50 summary: The Polish Blood Transfusion Act of 22nd August 1997, in force since January 1st 1999, has been supplemented by 8 Decrees: 1. procedures for external BTS audits; 2. requirements for donor selection; 3. requirements and procedures for organization and safe management of blood transfusion in hospitals; 4. requirements for implementing of national and regional donor registers; 5. employment criteria for BTS personnel; 6. training requirements for hospital personnel involved in blood and blood product administration; 7. national, uniform price list for blood and blood products; 8. organization requirements for setting up of a National Committee for Blood and Blood Transfusion. Introduction: TRALI is a life threatening adverse reaction of blood transfusion. keywords: aim; analysis; anti; antibodies; antibody; antigens; apheresis; assay; associated; background; blood banking; blood banks; blood cells; blood center; blood collection; blood components; blood donation; blood donors; blood establishments; blood group; blood loss; blood plasma; blood pressure; blood products; blood safety; blood samples; blood service; blood supply; blood system; blood transfusion; blood units; blood volume; cases; clinical; complications; concentrates; conclusion; control; cord blood; count; data; day; days; detection; disease; dna; donations; effect; events; factor; ffp; following; frequency; general; groups; hbsag; hbv; hcv; health; high; hla; hospital; hospital blood; identification; important; increase; infections; information; introduction; iron; laboratory; level; low; major; management; mean; medical; methods; national; negative; new; non; number; order; patients; pcr; period; plasma; platelet; platelet transfusion; population; positive; post; practice; presence; present; procedure; process; quality; range; rbc; rbc transfusion; rbcs; red; results; rhd; risk; routine; screening; serum; specific; standard; storage; studies; study; surgery; system; table; test; tested; testing; therapy; time blood; total; transfusion medicine; transfusion reactions; transfusion service; transfusion therapy; transfusions; treatment; type; use; weak; women; years cache: cord-023364-ut56gczm.txt plain text: cord-023364-ut56gczm.txt item: #482 of 2876 id: cord-023483-owgs4syo author: Marshall, John L title: Colorectal cancer care in the age of coronavirus: strategies to reduce risk and maintain benefit date: 2020-04-16 words: 2838 flesch: 41 summary: [3] that cancer patients are at increased risk of severe illness if they are to develop a COVID-19 infection and there is even some evidence to suggest that healthcare providers are at increased risk, possibly due to exposure to larger viral loads and repeated exposure [4, 5] . A novel coronavirus from patients with pneumonia in China Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists'perspective Epidemiology of COVID-19 in a long-term care facility in King County Viral dynamics in mild and severe cases of COVID-19 International guidelines on radiation therapy for breast cancer during the COVID-19 pandemic Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic: executive summary (2020). keywords: cancer; covid-19; months; patients; risk; treatment cache: cord-023483-owgs4syo.txt plain text: cord-023483-owgs4syo.txt item: #483 of 2876 id: cord-023509-tvqpv6fp author: Corrin, Bryan title: Occupational, environmental and iatrogenic lung disease date: 2011-03-02 words: 42595 flesch: 39 summary: Aluminium powder holds a paradoxical position in regard to lung disease. 366 More directly, welders may be exposed to asbestos insulation that they themselves use, while welders of special steel alloys run the risk of metal-induced asthma, metal fume fever, polymer fume fever and the consequences of toxic metal fume inhalation, 367 all of which are described separately in this chapter, as is lung disease in aluminium welders. keywords: acute; air; aluminium; alveolar; analysis; asbestos; asbestos exposure; asbestos fibres; asthma; beryllium; blood; bodies; bronchiolitis; cases; cause; cells; changes; chronic; coal; damage; diffuse; drug; dust; dust exposure; dust pneumoconiosis; effects; electron; emphysema; evidence; exposure; factor; fibres; fibrosis; fig; gas; interstitial; lesions; lung; lung cancer; lung disease; lung injury; lung tissue; macrophages; mineral; non; occupational; oedema; oxygen; particles; patients; pneumoconiosis; pneumonia; pulmonary; risk; silica; silicosis; smoking; study; syndrome; tissue; toxicity; type; water; workers cache: cord-023509-tvqpv6fp.txt plain text: cord-023509-tvqpv6fp.txt item: #484 of 2876 id: cord-023592-w96h4rir author: None title: Abstracts cont. date: 2015-12-28 words: 67976 flesch: 48 summary: The maximum amino acid identities of genes among different non-antibiotic-producing bacterial isolates were close to 100% for most genes, but those between antibiotic-producing and human or animal bacteria ranged from <28 to <77%. Results: Seven or eight participants provided qualifying results in the two separate QC studies, and the calculated (proposed) ranges were (range; % results in range): E. faecalis ATCC 29212 (2-8 mg/ L; 95.6), S. aureus ATCC 29213 (0.5-2 mg/L; 99.4), S. pneumoniae ATCC 49619 (0.25-1 mg/L; 97.5 and 30-37 mm; 97.6), H. influenzae ATCC 49247 (1-4 mg/L; 97.5 and 24-32 mm; 99.8), and S. aureus ATCC 25923 keywords: activity; aeruginosa; agar; agents; aim; analysis; antibiotic; antimicrobial; aureus; bacterial; beta; blood; candida; cases; catheter; cfu; ciprofloxacin; clinical; coli; conclusions; control; culture; data; days; detection; dna; esbl; faecium; genes; gram; group; hospital; human; identification; infection; isolates; lactamase; methods; mic; mice; mics; mortality; mrsa; nccls; negative; new; non; number; objectives; pathogens; patients; pcr; period; pfge; pneumoniae; positive; presence; prevalence; producing; production; pylori; range; resistance; results; salmonella; samples; sequence; species; specific; specimens; spp; strains; study; susceptibility; system; tested; tests; therapy; time; total; toxin; treatment; type; vancomycin; years cache: cord-023592-w96h4rir.txt plain text: cord-023592-w96h4rir.txt item: #485 of 2876 id: cord-023622-tul7bonh author: None title: Rotaviruses of Man and Animals date: 1975-02-01 words: 1953 flesch: 43 summary: Stools may be extremely rich in virus particles-there may be 109 to 1010 particles per gramme of faeces. Virus-infected organ cultures may be used for titrating antibody by I.F., and this provides a method that is rather more sensitive than c.F.; an effective c.F. antigen may be simply prepared from stool extracts rich in virus particles. keywords: cause; gastroenteritis; particles; patients; viruses cache: cord-023622-tul7bonh.txt plain text: cord-023622-tul7bonh.txt item: #486 of 2876 id: cord-023669-3ataw6gy author: Masur, Henry title: Critically Ill Immunosuppressed Host date: 2009-05-15 words: 11198 flesch: 30 summary: HIV patients pose a risk to health care professionals, however. For such patients, mucormycosis and non-albicans Candida are becoming more prominent causes of morbidity. keywords: cd4; ciency; cmv; diagnosis; disease; drugs; empiric; hiv; immunodefi; infection; lymphocyte; neutropenia; organ; patients; pneumonia; risk; specifi; therapy cache: cord-023669-3ataw6gy.txt plain text: cord-023669-3ataw6gy.txt item: #487 of 2876 id: cord-023729-dipjubn7 author: Serlin, Michael H. title: Gastrointestinal Disorders in HIV date: 2009-05-15 words: 5864 flesch: 40 summary: Pneumocystis jiroveci (PCP) can also be seen as the cause of diarrhea in HIV patients, but is very uncommon, especially in the setting of PCP prophylaxis for AIDS patients; treatment is with antipneumocystis therapy, 38 generally with trimethoprim-sulfamethoxazole. Patients can have both dysphagia and odynophagia, and because they also may have more than one illness concurrently, it is imperative to pursue a thorough investigation as to the etiology of esophageal complaints in HIV patients. keywords: addition; diarrhea; disease; esophageal; esophagitis; hiv; hiv patients; patients; therapy; treatment cache: cord-023729-dipjubn7.txt plain text: cord-023729-dipjubn7.txt item: #488 of 2876 id: cord-023833-xpfibjh2 author: Kilickaya, O. title: Structured Approach to Early Recognition and Treatment of Acute Critical Illness date: 2014 words: 3387 flesch: 28 summary: Critical care and the global burden of critical illness in adults The value of critical care One-year mortality, quality of life and predicted life-time cost-utility in critically ill patients with acute respiratory failure Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock To Err is Human : Building a Safer Health System Developing and pilot testing quality indicators in the intensive care unit Knowledge translation in critical care: factors associated with prescription of commonly recommended best practices for critically ill patients Patient safety in intensive care medicine: the Declaration of Vienna Clinical review: the hospital of the future -building intelligent environments to facilitate safe and effective acute care delivery The Checklist Manifesto : How To Get Things Right, 1st edn Evidence-based reviews and databases: are they worth the effort? In the current system, much of the effort in critical care is reactionary rather than proactive in implementing best practices aimed at preventing complications. keywords: acute; approach; care; checklist; critical; illness; information; patients; support; treatment cache: cord-023833-xpfibjh2.txt plain text: cord-023833-xpfibjh2.txt item: #489 of 2876 id: cord-023873-fidpskcs author: Meersseman, Wouter title: Invasive Aspergillosis in the Intensive Care Unit: Beyond the Typical Haematological Patient date: 2009-05-04 words: 4145 flesch: 37 summary: A summary of available studies in ICU patients is listed in Table 1 In other groups, including ICU patients, similar CT-findings are frequently absent and, if present, are far less specific [4] . keywords: aspergillosis; aspergillus; diagnosis; galactomannan; icu; lung; patients; risk cache: cord-023873-fidpskcs.txt plain text: cord-023873-fidpskcs.txt item: #490 of 2876 id: cord-023913-pnjhi8cu author: Foreman, Stephen title: Broader Considerations of Medical and Dental Data Integration date: 2011-10-08 words: 47672 flesch: 38 summary: Over the past decade evidence has been building that there is a relationship between dental disease, particularly periodontal disease, and chronic illnesses. Dentists will need to be alert for early signs of chronic illness among their patients and physicians will need to be alert for signs of dental disease. keywords: access; association; benefi; care costs; caries; case; children; chronic; clinic; community; conditions; costs; coverage; data; dental; dentistry; dentists; diabetes; disease; education; ehr; et al; example; fig; genome; health; health care; health insurance; health record; healthcare; infl; information; insurance; management; medicaid; medical; medicare; medicine; national; need; new; number; oral; patient; patient care; periodontitis; population; practice; primary; program; providers; public; quality; record; report; research; risk; schools; students; studies; study; system; treatment; use; years cache: cord-023913-pnjhi8cu.txt plain text: cord-023913-pnjhi8cu.txt item: #491 of 2876 id: cord-024073-243addff author: Richards, Guy title: COVID-19 and the Rationale for Pharmacotherapy: A South African Perspective date: 2020-04-17 words: 3411 flesch: 34 summary: FDA authorize s widespread use of unproven drugs to treat coronavirus, saying possible benefit outweighs risk Advisory on the use of hydroxy-chloroquine as prophylaxis for SARS-Cov 2 infection Extraordinary GU rich-rich single strand RNA identified from SARS coronavirus contributes an excessive innate immune response Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel middle east respiratory syndrome coronavirus: implications for pathogenesis and treatment Aberrant pathogenic GM-CSF + T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus Effective treatment of severe COVID-19 patients with tocilizumab National Health Commission (NHC) of the People's Republic of China. Coronavirus infectionsmore than just the common cold Epidemic models of contact tracing: systematic review of transmission studies of severe acute respiratory syndrome and Middle East respiratory syndrome Rapid response: Re: preventing a Covid-19 pandemic -is there a magic bullet to save COVID-19 patients? keywords: clinical; coronavirus; covid-19; disease; mortality; patients; study; therapy; treatment cache: cord-024073-243addff.txt plain text: cord-024073-243addff.txt item: #492 of 2876 id: cord-024120-3eemj37r author: Schiff, Gordon D. title: An Interview with Gordon D. Schiff date: 2020-04-29 words: 5177 flesch: 38 summary: So, for me, the origins and connections between medication safety and diagnosis safety run deep. Yet I learned so much from my patients, the dedicated staff, and quality advocates at County about system errors, engagement, compassion, advocacy, humility, and personally connecting with our patients, that I felt I had a lifetime of knowledge and relationships to draw on. keywords: care; diagnosis; errors; health; medication; patients; prescribing; quality; safety; support; systems; time; work cache: cord-024120-3eemj37r.txt plain text: cord-024120-3eemj37r.txt item: #493 of 2876 id: cord-024130-kgzegwon author: Ankita title: COVID-19: An Ophthalmological Update date: 2020-04-30 words: 2851 flesch: 46 summary: According to a recently published literature on COVID-19 conjunctivitis, tear sample and conjunctival swab are reported to be positive for the novel coronavirus. The treatment of COVID-19 conjunctivitis is an ongoing research (National Institutes of Health 2020). keywords: care; conjunctival; conjunctivitis; coronavirus; covid-19; disease; patients cache: cord-024130-kgzegwon.txt plain text: cord-024130-kgzegwon.txt item: #494 of 2876 id: cord-024189-t7mbsr25 author: Weyand, Cornelia M. title: Vasculitides date: 2008 words: 26662 flesch: 38 summary: The P-ANCA pattern, which usually corresponds to the presence of MPO-ANCA in vasculitis patients, occurs in approximately 10% of patients with WG, but is more typical of MPA, the CSS, and renal-limited vasculitis. No pathognomic test for PMR is available; exclusion of other diseases with similar clinical presentations is essential. keywords: ammation; ammatory; anca; arteries; arteritis; artery; biopsy; blood; cases; cell; diagnosis; disease; figure; gca; glucocorticoids; immune; infi; infl; involvement; kawasaki; lesions; manifestations; ndings; pan; patients; renal; symptoms; syndrome; system; therapy; tissue; treatment; vascular; vasculitis; vessel; years cache: cord-024189-t7mbsr25.txt plain text: cord-024189-t7mbsr25.txt item: #495 of 2876 id: cord-024233-hrzpxdh0 author: None title: In This Issue/Research Watch/News in Brief date: 2020-04-24 words: 3272 flesch: 44 summary: 4 of 16 (25%) cancer patients with COVID-19 had received chemotherapy or surgery within the past month. Importantly, cancer patients were more likely to have severe adverse events such as intensive care unit admission, invasive ventilation or death compared with those without cancer (39% vs 8%). keywords: brain; cancer; cell; memantine; months; patients; time; treatment cache: cord-024233-hrzpxdh0.txt plain text: cord-024233-hrzpxdh0.txt item: #496 of 2876 id: cord-024614-6bu3zo01 author: Tang, Daxing title: Prevention and control strategies for emergency, limited-term, and elective operations in pediatric surgery during the epidemic period of COVID-19 date: 2020-03-26 words: 5846 flesch: 38 summary: Pneumonia diagnosis and treatment plan for new coronavirus infection (trial version 5 revision) (in Chinese Announcement of National Health Commission of the People's Republic of China Perioperative prevention and control strategies for surgical patients in the context of new coronavirus pneumonia (in Chinese) Consensus on emergency surgery and infection prevention and control for severe trauma patients with 2019 novel coronavirus pneumonia For pediatric patients that cry more often and do not cooperate, appropriate sedation can be applied before surgery to reduce the risk of transmission of saliva and droplet. keywords: children; control; coronavirus; covid-19; epidemic; infection; medical; operation; patients; prevention; protection; surgery cache: cord-024614-6bu3zo01.txt plain text: cord-024614-6bu3zo01.txt item: #497 of 2876 id: cord-024651-578c9ut5 author: None title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 words: 84772 flesch: 43 summary: CARD11 deficiency was confirmed by stimulating patient B cells with phorbol 12-myristate 13 acetate (PMA) and ionomycin and immunoblotting for signalling proteins in both the NF-κB (IKKα/β, IκBα, p65) and MAPK (MEK1/2, MKK4, JNK1/2, ERK1/2) pathways as well as cleavage substrates of the MALT1 paracaspase (RELB, CYLD, BCL10, HOIL1). Furthermore, RNA-Seq confirmed the developmental block observed in patient B cells and suggested that B cells were halted at the centroblast to centrocyte transition. keywords: abstract; age; alps; analysis; anti; autoimmune; b cells; biopsy; blood; bone; case; case report; cd4; cd8; cells; cgd; children; chronic; clinical; cohort; conclusion; cvid; data; days; deficiency; diagnosis; disease; disorders; dysregulation; elevated; evaluation; exome; expression; family; features; female; findings; function; gene; genetic; group; heterozygous; hies; high; history; hospital; hsct; iga; igg; igm; immune; immunodeficiency; immunoglobulin; immunology; improvement; infections; inflammatory; introduction; ivig; laboratory; levels; low; lung; lymphocyte; lymphoma; male; manifestations; marrow; memory; methods; months; mutations; non; normal; patients; phenotype; pid; pid patients; pneumonia; positive; post; presentation; primary; protein; range; recurrent; report text; response; results; rituximab; scid; secondary; sequencing; signaling; skin; stat3; studies; study; symptoms; syndrome; t cells; testing; text; therapy; time; total; transplant; treatment; use; variant; weeks; years cache: cord-024651-578c9ut5.txt plain text: cord-024651-578c9ut5.txt item: #498 of 2876 id: cord-024795-xa7ke70d author: Kaviani, Aaron title: Management of Antimicrobial Agents in Abdominal Organ Transplant Patients in Intensive Care Unit date: 2020-01-24 words: 4878 flesch: 31 summary: Therapeutic advances in infectious disease Sepsis and solid organ transplantation Sepsis in solid-organ transplant patients AST handbook of transplant infections Candida infections in solid organ transplantation: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice Empirical fluconazole versus placebo for intensive care unit patients: a randomized trial Empirical micafungin treatment and survival without invasive fungal infection in adults with ICU-acquired sepsis, Candida colonization, and multiple organ failure: the EMPIRICUS randomized clinical trial Invasive fungal infections in solid organ transplant recipients Fungal infections in renal transplant patients 2019:e13545. The main sources of infection in the first month after SOT include donor-derived infections, preexisting recipient infections, surgical complications, and nosocomial infections including Clostridium difficile infection (CDI). keywords: infections; liver; organ; patients; recipients; risk; sot; transplant; transplantation; treatment cache: cord-024795-xa7ke70d.txt plain text: cord-024795-xa7ke70d.txt item: #499 of 2876 id: cord-024833-e6vcf4un author: None title: Forum date: 2019-12-19 words: 8121 flesch: 44 summary: A new requirement of the Cures Act was for the FDA to make its best practices for drug safety surveillance publicly available on the web. The FDA has now announced the availability of a draft document entitled Best Practices in Drug and Biological Product Postmarket Safety Surveillance for FDA Staff, which outlines the agency's approach to timely postmarketing analyses of drugs and biologics, and includes a high-level overview of tools, methods, and signal detection and evaluation activities, using varied data sources, for drug safety surveillance to provide a broader context and a general overview of our overarching effort and commitment in this area, says Woodcock. keywords: age; authors; cases; data; drug; events; fda; health; healthcare; new; patients; products; reporting; reports; risk; safety; signals; study; use; vaccine; years cache: cord-024833-e6vcf4un.txt plain text: cord-024833-e6vcf4un.txt item: #500 of 2876 id: cord-024893-pd67o7l8 author: Li, Lanjuan title: Translation: Expert Consensus on the Application of Artificial Liver Blood Purification System in the Treatment of Severe and Critical COVID-19: National Clinical Research Center for Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases date: 2020-04-17 words: 1338 flesch: 26 summary: Led by Academician Lanjuan Li, based on the experience of treating patients across the country, integrating the opinions of experts from all over the country, the center summarized and formulated the consensus including the basic principles, treatment indications, relative contraindications, mode selection, monitoring indicators, and efficacy evaluation of artificial liver, which provides reference for treatment of severe COVID-19 patients. 10 Patients should receive ALSS treatment if they meet criteria (1) & (2), or only (3). keywords: covid-19; patients; plasma; treatment cache: cord-024893-pd67o7l8.txt plain text: cord-024893-pd67o7l8.txt item: #501 of 2876 id: cord-024956-oht0v33s author: Yu, Minhua title: Thin-section Chest CT Imaging of Coronavirus Disease 2019 Pneumonia: Comparison Between Patients with Mild and Severe Disease date: 2020-04-23 words: 2502 flesch: 43 summary: Patients with severe form of the disease had more extensive opacification of the lung parenchyma than did patients with mild disease. Patients with mild form of disease showed pure GGO more often than patients with severe disease, while the latter was more frequently associated with pure consolidations. keywords: covid-19; disease; form; patients; pneumonia cache: cord-024956-oht0v33s.txt plain text: cord-024956-oht0v33s.txt item: #502 of 2876 id: cord-025157-7b3v5yct author: Darreau, C. title: Use, timing and factors associated with tracheal intubation in septic shock: a prospective multicentric observational study date: 2020-05-24 words: 3621 flesch: 37 summary: Neurological, respiratory and hemodynamic parameters only partially explained the use of tracheal intubation in septic shock patients. To assess use, timing and factors associated with tracheal intubation in septic shock patients, we conducted a multicenter observational prospective study in 30 intensive care units (ICUs) in France and Spain. keywords: failure; intubation; parameters; patients; shock; study; ventilation cache: cord-025157-7b3v5yct.txt plain text: cord-025157-7b3v5yct.txt item: #503 of 2876 id: cord-025164-hqj22yxe author: Renew, J. Ross title: Neuromuscular blockade management in the critically Ill patient date: 2020-05-24 words: 8196 flesch: 27 summary: Management of the airway of ICU patients presents multiple and varied challenges, as it is one of the most commonly performed procedures in this setting. Despite the availability of indicators of difficult airway in ICU patients, however, a recent French survey found that 43% of intubating operators were still not fully proficient in the technique, with 18.8% of them having had no intubation training, or only basic training, such as lectures or observation keywords: airway; blockade; blocking; care; guidelines; icu; intensive; intubation; management; nmbas; patients; risk; rocuronium; setting; use cache: cord-025164-hqj22yxe.txt plain text: cord-025164-hqj22yxe.txt item: #504 of 2876 id: cord-025170-dtbm4ue1 author: Malbrain, Manu L. N. G. title: Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA) date: 2020-05-24 words: 9185 flesch: 34 summary: Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis Intravenous balanced solutions: from physiology to clinical evidence It is time to consider the four D's of fluid management Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults Resuscitation fluids National Institute for H, Care Excellence Guideline Development G. Intravenous fluid therapy for adults in hospital: summary of NICE guidance Intravenous fluid therapy for hospitalized and critically ill children: rationale, available drugs and possible side effects Principles of fluid management and stewardship in septic shock: it is time to consider the four D's and the four phases of fluid therapy Effect of isotonic versus hypotonic maintenance fluid therapy on urine output, fluid balance, and electrolyte homeostasis: a crossover study in fasting adult volunteers Maintenance intravenous fluids in acutely ill patients Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population Normal saline to dilute parenteral drugs and to keep catheters open is a major and preventable source of hypernatremia acquired in the intensive care unit Mortality after fluid bolus in African children with severe infection Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia Fluid overload, de-resuscitation, and outcomes in critically ill or injured patients: a systematic review with suggestions for clinical practice Independent and dependent variables of acid-base control Stewartìs textbook of acid-base Lulucom Electrolyte shifts across the artificial lung in patients on extracorporeal membrane oxygenation: interdependence between partial pressure of carbon dioxide and strong ion difference Crystalloid strong ion difference determines metabolic acid-base change during in vitro hemodilution Effects of intravenous solutions on acid-base equilibrium: from crystalloids to colloids and blood components In vivo conditioning of acid-base equilibrium by crystalloid solutions: an experimental study on pigs Resuscitation fluids are used to correct an intravascular volume deficit or acute hypovolemia; replacement solutions are prescribed to correct existing or developing deficits that cannot be compensated by oral intake alone keywords: administration; albumin; balance; care; crystalloids; fluid; intravenous; patients; pressure; renal; resuscitation; shock; solutions; surgery; therapy; trial; volume cache: cord-025170-dtbm4ue1.txt plain text: cord-025170-dtbm4ue1.txt item: #505 of 2876 id: cord-025172-qg3jxgch author: Covarrubias, Jose title: Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date: 2020-05-24 words: 2819 flesch: 49 summary: key: cord-025172-qg3jxgch authors: Covarrubias, Jose; Grigorian, Areg; Kuza, Catherine M.; Dolich, Matthew; Dosch, Austin; Kojayan, Greg G.; Delaplain, Patrick; Lekawa, Michael; Nahmias, Jeffry title: Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis date: 2020-05-24 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01402-4 sha: doc_id: 25172 cord_uid: qg3jxgch BACKGROUND: The Trauma Quality Improvement Program was queried to identify trauma patients ≥ 18 years of age with HIV. keywords: complications; hiv; injury; patients; study; trauma cache: cord-025172-qg3jxgch.txt plain text: cord-025172-qg3jxgch.txt item: #506 of 2876 id: cord-025176-f0frlpwh author: Coimbra, Raul title: Resuming elective surgical services in times of COVID-19 infection date: 2020-05-19 words: 2888 flesch: 36 summary: COVID-19: recommendations for management of elective surgical procedures Re-opening facilities to provide nonemergent non-COVID-19 healthcare: phase I Recovery of surgical services during and after COVID-19 American Association of Orthopaedic Surgeons Guidance for resuming GI endoscopy and practice operations after the COVID-19 pandemic National Coronavirus Response: a road map to reopening Association of periOperative Registered Nurses and the American Hospital Association Recommendation to optimize safety of elective surgical care while limiting the spread of COVID-19: primum non nocere Joint statement on re-introduction of hospital and office-based procedures in the COVID-19 climate for the practicing urogynecologist and gynecologist. Therefore, when considering resuming elective surgical care, the first step is to understand the COVID-19 infection prevalence and incidence in the community and the current impact in a hospital. keywords: care; covid-19; hospital; patients; stage; surgery; time cache: cord-025176-f0frlpwh.txt plain text: cord-025176-f0frlpwh.txt item: #507 of 2876 id: cord-025666-u8w4sk07 author: Edgar, DW title: Seeding the value based health care and standardised measurement of quality of life after burn debate date: 2020-05-30 words: 1671 flesch: 46 summary: The paucity of outcome measures in burn care The official update of the POSAS: [9] for generic QoL measurement in adult burn patients. keywords: burn; health; life; patient; qol cache: cord-025666-u8w4sk07.txt plain text: cord-025666-u8w4sk07.txt item: #508 of 2876 id: cord-025749-mip9mkef author: Jo, Sungyang title: Newly developed stroke in patients admitted to non-neurological intensive care units date: 2020-06-02 words: 4137 flesch: 41 summary: We defined stroke according to the findings on CT and/or MRI images of the brain, but only 22% of ICU patients underwent such neuroimaging studies, so patients who developed stroke but did not undergo neuroimaging studies, due to very unstable vital signs and early death soon after admission to the ICU, may not have been identified as having IOS. Patients with altered mental status as an initial stroke manifestation had time delays to the stroke recognition than patients without altered mental status (p = 0.027), while patients with seizure as an initial stroke manifestation had shorter time intervals for the stroke recognition than patients without seizure (p = 0.047). keywords: icu; ios; ischemic; mortality; patients; stroke; time cache: cord-025749-mip9mkef.txt plain text: cord-025749-mip9mkef.txt item: #509 of 2876 id: cord-025990-nj4ah2yz author: Konca, Capan title: Susceptibility Patterns of Multidrug-Resistant Acinetobacter baumannii date: 2020-06-04 words: 3227 flesch: 44 summary: An alarming development is the increasing resistance to this drug, which is used as the first choice of treatment for MDRAB patients. The authors retrospectively evaluated the medical records of patients with MDRAB infections in the PICU during a follow-up period, between January 2015 and January 2017. keywords: baumannii; colistin; isolates; mdrab; patients; resistance; study cache: cord-025990-nj4ah2yz.txt plain text: cord-025990-nj4ah2yz.txt item: #510 of 2876 id: cord-026025-xqj877en author: PETRAS, ROBERT E. title: Large Intestine (Colon) date: 2009-10-30 words: 48346 flesch: 37 summary: Large cell carcinoma and small cell carcinoma of the colon and rectum have a poor prognosis. A phase II trial with preliminary evidence of antiviral activity and low incidence of opportunistic infection Multicenter trial of lowdose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma Docetaxel in anthracycline-pretreated AIDS-related Kaposi's sarcoma: A retrospective study Angiosarcoma of the colon and rectum: Report of a case and review of the literature Endoscopic management of rectal Dieulafoy-like lesions: A case series and review of literature Familial Polyposis Coli The Pathogenesis of Colorectal Cancer Cribriform-morular variant of papillary carcinoma: A distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma Gastric and duodenal polyps in familial adenomatous polyposis: A prospective study of the nature and prevalence of upper gastrointestinal polyps Fundic gland polyps in familial adenomatous polyposis: Neoplasms with frequent somatic adenomatous polyposis coli gene alterations The risk of upper gastrointestinal cancer in familial adenomatous polyposis Localization of the gene for familial adenomatous polyposis on chromosome 5 The gene for familial polyposis coli maps to the long arm of chromosome 5 Identification and characterization of the familial adenomatous polyposis coli gene Identification of FAP locus genes from chromosome 5q21 Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients The multiple colorectal adenoma phenotype and MYH, a base excision repair gene Responsive colon cancer cell lines to the introduction of APC, a colon-specific tumor suppressor gene Familial adenomatous polyposis Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients Attenuated familial adenomatous polyposis (AFAP). keywords: acute; adenocarcinoma; adenomas; analysis; associated; biopsy; bowel; bowel disease; cancer; carcinoma; cases; cause; cells; changes; chronic; colitis; colon; colonic; colorectal; crohn; diagnosis; diarrhea; disease; dysplasia; epithelial; features; fig; gastrointestinal; gene; grade; histologic; ibd; infection; inflammation; inflammatory; intestinal; ischemic; lamina; lesions; mucosal; occur; patients; pattern; polyposis; polyps; pouch; propria; rectum; risk; specimens; study; surveillance; syndrome; tract; treatment; tumor; type; years cache: cord-026025-xqj877en.txt plain text: cord-026025-xqj877en.txt item: #511 of 2876 id: cord-026031-hnf5vayd author: Ford, Richard B. title: Emergency Care date: 2009-05-21 words: 112481 flesch: 42 summary: animal patients. The normal CVP for small animal patients is 0 to 5 cm H 2 O. Values less than zero are associated with absolute or relative hypovolemia. keywords: abnormalities; acute; administer; administration; airway; animal; bandage; blood; blood pressure; body; cardiac; care; cases; catheter; cats; cause; charcoal; control; crystalloid; damage; days; decrease; diagnosis; disease; dogs; dose; drugs; dysrhythmias; edema; effects; effusion; emergency; emesis; examination; exposure; failure; fluid; following; function; gastrointestinal; heart; hemorrhage; hours; infection; ingestion; injury; intravenous; kg iv; kg po; lavage; loss; management; minutes; monitor; needle; normal; obstruction; occurs; oxygen; pain; patient; perform; perfusion; place; plasma; presence; present; pressure; pulmonary; radiographs; rate; renal; result; risk; saline; secondary; seizures; serum; shock; signs; skin; sodium; solution; supplemental; therapy; thoracic; time; tissue; toxicity; trauma; treatment; tube; urine; volume; vomiting; water; wound cache: cord-026031-hnf5vayd.txt plain text: cord-026031-hnf5vayd.txt item: #512 of 2876 id: cord-026392-cvb44v5v author: Dahlberg, Jørgen title: Barriers and challenges in the process of including critically ill patients in clinical studies date: 2020-06-08 words: 4783 flesch: 47 summary: Our study revealed that 38% of patient consents were oral, even though study investigators tried to obtain written consent whenever possible. Evaluating patient capacity in practice Informed consent during the clinical emergency of acute myocardial infarction (HERO-2 consent substudy): a prospective observational study Informed consent in clinical trials in critical care: experience from the PAC-man study An ethical analysis of proxy and waiver of consent in critical care research European legislation impedes critical care research and fails to protect patients' rights Confronting the ethical challenges to informed consent in emergency medicine research Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results Research without informed patient consent in incompetent patients keywords: care; challenges; consent; kin; patients; research; study cache: cord-026392-cvb44v5v.txt plain text: cord-026392-cvb44v5v.txt item: #513 of 2876 id: cord-026653-094bk0t0 author: Gülsen, Askin title: Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events* date: 2020-06-24 words: 14021 flesch: 44 summary: ADA were detected in 2-8 % of treated patients, and two subjects developed serum sickness or serum sickness-like reactions. In the last published FDA label, IRs and cytokine release syndrome were reported in 92 % of treated patients, but epinephrine or atropine was administered in 0.6 % of these patients [54] . keywords: anaphylaxis; assessment; cancer; drug; fda; hsrs; hypersensitivity; infusion; irs; isrs; labels; pain; patients; rash; reactions; report; study; symptoms; treatment; urticaria cache: cord-026653-094bk0t0.txt plain text: cord-026653-094bk0t0.txt item: #514 of 2876 id: cord-026846-3u3x52f8 author: None title: Inside This Issue date: 2020-06-22 words: 361 flesch: 34 summary: In this document, the authors suggest guidelines for how to triage patients in need of structural heart disease interventions and provide a framework for how to decide when it may be appropriate to proceed with intervention despite the ongoing pandemic. The effective triage of these patients has become challenging in the current environment as clinicians have had to weigh the risk of bringing susceptible patients into the hospital environment during the COVID-19 pandemic against the risk of delaying a needed procedure. keywords: patients cache: cord-026846-3u3x52f8.txt plain text: cord-026846-3u3x52f8.txt item: #515 of 2876 id: cord-026868-z9gozm2w author: Mohammad, Abeer title: “She’s dead!” – Nursing simulation practices: A discourse analysis approach date: 2020-06-11 words: 5469 flesch: 39 summary: Based on an investigation involving a similar context in Saudi Arabia as that involved in the current study, Omer surveyed Saudi nursing students' satisfaction and self-confidence after clinical simulation sessions and reported students' overall satisfaction with simulation-based training as well as the simulations' positive impact on their acquisition and retention of clinical knowledge. US Agency for Healthcare Research and Quality Nursing students' perceptions of satisfaction and selfconfidence with clinical simulation experience Evaluation of simulation in undergraduate nurse education: An integrative review New graduate nurses' perceptions of the effects of clinical simulation on their critical thinking, learning, and confidence A computer-based trauma simulator for teaching trauma management skills Undergraduate nursing students' acquisition and retention of CPR knowledge and skills Effectiveness of simulation-based learning on student nurses' self-efficacy and performance while learning fundamental nursing skills A nurse residency program for competency development using human patient simulation keywords: faculty; line; nurse; patient; sessions; simulation; students; team cache: cord-026868-z9gozm2w.txt plain text: cord-026868-z9gozm2w.txt item: #516 of 2876 id: cord-026879-gwzrdeb1 author: Zarrintan, Armin title: Rapidly progressive COVID-19 viral pneumonia: a report of two patients with a focus on imaging findings date: 2020-06-16 words: 1754 flesch: 49 summary: We suggest that the clinical course of the virus may be rapidly progressive in some patients, and special attention should be paid to patients being treated for the virus outside of the hospital as an outpatient. These studies are done on a limited number of patients, and most of them report information gathered from cases originating from mainland China [2] . keywords: disease; patient; study cache: cord-026879-gwzrdeb1.txt plain text: cord-026879-gwzrdeb1.txt item: #517 of 2876 id: cord-026991-75sbxnsc author: Sultan, Omar Muayad title: Pulmonary ct manifestations of COVID-19: changes within 2 weeks duration from presentation date: 2020-06-17 words: 2902 flesch: 50 summary: Therefore, CT scan is done at different times in different institutions worldwide necessitating that specific consideration to be taken for such observed difference in the appearance of CT pulmonary findings according to the time of the scans. There is evidence of the prognostic value of chest CT which has been shown by recent studies, where a specific score by CT scan could predict the mortality of patients with COVID-19 keywords: changes; covid-19; group; patients; study cache: cord-026991-75sbxnsc.txt plain text: cord-026991-75sbxnsc.txt item: #518 of 2876 id: cord-027259-f4sgobcz author: Metsker, Oleg title: Stroke ICU Patient Mortality Day Prediction date: 2020-05-23 words: 5336 flesch: 38 summary: According to the findings of a large-scale study of recent years, some modern epidemiological trends have been identified [3] : In general, global statistics show a decline in stroke mortality over the past two decades due to the introduction of new treatments (thrombolysis, thrombectrosis), but the absolute number of people who have stroke is only increasing every year The unmodifiable factors of stroke mortality include: gender, age, type of stroke, localization of lesion. keywords: brain; data; days; hospital; hospital mortality; ischemic; models; mortality; patients; rate; stroke; subgroups cache: cord-027259-f4sgobcz.txt plain text: cord-027259-f4sgobcz.txt item: #519 of 2876 id: cord-027266-jdti1pwa author: Derevitskii, Ilya V. title: The Atrial Fibrillation Risk Score for Hyperthyroidism Patients date: 2020-05-23 words: 4050 flesch: 49 summary: To date, a lot of data have been obtained about thyrotoxic atrial fibrillation risk factors. On base Logistic Regression model, we can create a scale for estimated atrial fibrillation risk. keywords: fibrillation; heart; model; patients; risk; thyrotoxicosis cache: cord-027266-jdti1pwa.txt plain text: cord-027266-jdti1pwa.txt item: #520 of 2876 id: cord-027551-a92lv4sh author: Pinto, Eleonora title: QOLEC2: a randomized controlled trial on nutritional and respiratory counseling after esophagectomy for cancer date: 2020-06-22 words: 4425 flesch: 34 summary: In an interesting double-blind, placebo-controlled, randomized crossover study, esophagectomy patients and healthy controls received either 1 mL 0.9% saline or 1 mL (100 μg) octreotide acetate subcutaneously followed by a standardized ad libitum meal on each of two assessments [35] . Esophageal cancer Quality of life assessment in esophagectomy patients Systematic review of health-related quality of life after esophagectomy for esophageal cancer Health-related quality of life in patients with oesophageal cancer: analysis at different steps of the treatment pathway A systematic review of the nutritional consequences of esophagectomy Overweight patients operated on for cancer of the esophagus survive longer than normal-weight patients Feb-Mar) Longterm nutritional outcome and health related quality of life of patients following esophageal cancer surgery: a meta-analysis Impact of weight loss and eating difficulties on health-related quality of life up to 10 years after oesophagectomy for cancer Long-term quality of life after esophagectomy with gastric pull-up ) keywords: cancer; counseling; esophagectomy; group; life; months; nutritional; patients; quality; surgery cache: cord-027551-a92lv4sh.txt plain text: cord-027551-a92lv4sh.txt item: #521 of 2876 id: cord-027677-fc410vto author: GOULD, JANE M. title: Pharyngitis, Stomatitis, Peritonsillar, and Retropharyngeal Abscess date: 2020-06-22 words: 6199 flesch: 45 summary: Cough, in particular, is considered a negative predictor of GA␤HS pharyngitis. GA␤HS pharyngitis is endemic in the United States and accounts for 15% to 30% of all episodes of pharyngitis. keywords: abscess; acute; children; days; fever; infection; patients; pharyngitis; stomatitis; therapy cache: cord-027677-fc410vto.txt plain text: cord-027677-fc410vto.txt item: #522 of 2876 id: cord-027678-k64whepc author: Chan, Kai Man title: Pneumonia date: 2020-06-22 words: 6629 flesch: 35 summary: The role of PCR in diagnosing PCP is mainly limited to non-HIV patients, in whom conventional microscopy and staining of induced sputum and BAL have a lower sensitivity than in HIV patients. The pattern of TB in HIV patients coughs up material containing cysts and trophozoites. keywords: days; diagnosis; disease; guidelines; hiv; icu; infection; management; organisms; patients; pneumonia; sputum; treatment cache: cord-027678-k64whepc.txt plain text: cord-027678-k64whepc.txt item: #523 of 2876 id: cord-027805-p0bhju1s author: Wong, An-Kwok Ian title: Consequences and Solutions for the Impact of Communication Impairment on Noninvasive Ventilation Therapy for Acute Respiratory Failure: A Focused Review date: 2020-06-15 words: 4347 flesch: 32 summary: We therefore propose an investigation into the consequences of using AAC methods for enhancing communication in NIV patients. Analogous communication problems exist with effective solutions in other fields, such as fighter pilot masks, that can be easily implemented to enhance noninvasive ventilation patient care, increase adherence to noninvasive ventilation treatment, and improve patient outcomes. keywords: communication; failure; mask; niv; patients; speech; ventilation cache: cord-027805-p0bhju1s.txt plain text: cord-027805-p0bhju1s.txt item: #524 of 2876 id: cord-027860-s97hdhh6 author: Zeimet, Anthony title: Infectious Diseases date: 2020-06-22 words: 28951 flesch: 42 summary: Management of such patients should be coordinated with an infectious diseases specialist, who also should manage drug-resistant TB treatment. Single positive blood culture for Coxiella burnetii or anti-phase 1 IgG antibody titer >1:800 Echocardiogram positive for IE (TEE recommended for patients with prosthetic valves, rated at least possible IE by clinical criteria, or complicated IE [paravalvular abscess]; TTE as first test in other patients) defined as follows: oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation; or abscess; or new partial dehiscence of prosthetic valve; new valvular regurgitation (worsening or changing or preexisting murmur not sufficient) Predisposition, predisposing heart condition, or IDU Fever, temperature >38° C Vascular phenomena, major arterial emboli, septic pulmonary infarcts, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhages, and Janeway's lesions Immunologic phenomena: glomerulonephritis, Osler's nodes, Roth's spots, and rheumatoid factor Microbiologic evidence: positive blood culture but does not meet a major criterion as noted above * or serological evidence of active infection with organism consistent with IE Echocardiographic minor criteria eliminated Echocardiography should be performed in all patients with suspected infective endocarditis (Baddour et al., 2005) keywords: acute; adults; antibiotics; bacterial; bite; blood; cause; children; chronic; culture; daily; days; diagnosis; diarrhea; discharge; disease; endocarditis; fever; gram; hepatitis; infection; influenza; lesions; months; negative; pain; patients; present; risk; skin; sor; symptoms; testing; therapy; treatment; use; vaccine; virus; weeks; women; wounds cache: cord-027860-s97hdhh6.txt plain text: cord-027860-s97hdhh6.txt item: #525 of 2876 id: cord-028260-mja2jrgm author: Velasco Puyó, Pablo title: Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome() date: 2020-07-01 words: 905 flesch: 41 summary: Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality r o o f COVID-19, as suggested by Liang and colleagues, 2 but the evidence on paediatric cancer patients is scarce. keywords: covid-19; patients; tocilizumab cache: cord-028260-mja2jrgm.txt plain text: cord-028260-mja2jrgm.txt item: #526 of 2876 id: cord-028285-n4dommet author: Weilongorska, Natasha L. title: COVID-19: What are the challenges for NHS surgery? date: 2020-07-02 words: 9766 flesch: 42 summary: The need to segregate suspected or confirmed COVID-19 patients into designated operating rooms has spurred the use of traffic light systems to denote case status. Literature from other countries recommending negative pressure ventilation in the management of COVID-19 cases, 78,79 initially generated concern. keywords: cases; covid-19; guidance; healthcare; nhs; operating; pandemic; patients; ppe; risk; rooms; screening; services; staff; surgeons; surgery; surgical; testing cache: cord-028285-n4dommet.txt plain text: cord-028285-n4dommet.txt item: #527 of 2876 id: cord-028328-5lews3uw author: Haas, Andrew R. title: COMMUNITY-ACQUIRED PNEUMONIA date: 2020-06-22 words: 5073 flesch: 30 summary: [15] [16] For all patients presenting with CAP, Streptococcus pneumoniae is the most common pathogen isolated ( Fig. 78-1 ) and accounts for 5% to 11% of CAP patients treated on an ambulatory basis, 5% to 43% of patients requiring hospitalization, and 11% to 38% of patients requiring intensive care unit (ICU) admission. Unfortunately, even with extensive diagnostic evaluation, the etiologic agent is not identifi ed in as many as 50% of patients. keywords: cap; care; community; factors; pathogens; patients; pneumonia; resistance; risk; therapy; treatment cache: cord-028328-5lews3uw.txt plain text: cord-028328-5lews3uw.txt item: #528 of 2876 id: cord-028379-ghudhac6 author: Eichenberger, Emily M. title: Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria date: 2020-07-04 words: 5469 flesch: 45 summary: The horizontal lines compare medians across groups SAB patients as compared to community controls. We present complement levels in Staphylococcus aureus bacteremia (SAB) and Gram-negative bacteremia (GNB) and describe observed associations of complement levels with clinical outcomes. keywords: bacteremia; c5a; complement; controls; gnb; levels; patients; sab; shock cache: cord-028379-ghudhac6.txt plain text: cord-028379-ghudhac6.txt item: #529 of 2876 id: cord-028557-68jypaaw author: Joshi, Jaiteerth R. title: COVSACK: an innovative portable isolated and safe COVID-19 sample collection kiosk with automatic disinfection date: 2020-07-05 words: 3792 flesch: 50 summary: This technological innovation, to certain extent, has changed the way the testing of COVID-19 patients carried out in the country. Very recently in India, particularly in Kerala (Sruthi 2020) , telephone booth like chambers are employed for collection of samples from COVID-19 patients, where the healthcare worker is inside the booth, while the patients are outside. keywords: chamber; collection; covid-19; disinfectant; healthcare; kiosk; patients; sample; virus cache: cord-028557-68jypaaw.txt plain text: cord-028557-68jypaaw.txt item: #530 of 2876 id: cord-028590-rw0okd0p author: Westgarth, David title: What does the future hold for the workforce of tomorrow? date: 2020-07-06 words: 4659 flesch: 60 summary: 'It was worrying reading about the number of dental practices that said they may be forced to close and thinking about the knock-on effects this could have on our cohort in the longer term. While the authorities recently distributed more than three million individual items of PPE to dental practices, volumes are only sufficient to enable practices to see around 10 patients a day. keywords: dental; dentists; health; pandemic; patients; profession; support; time; work cache: cord-028590-rw0okd0p.txt plain text: cord-028590-rw0okd0p.txt item: #531 of 2876 id: cord-028709-r1inj3ra author: Spinazzola, Giorgia title: Pressure Support Ventilation (PSV) versus Neurally Adjusted Ventilatory Assist (NAVA) in difficult to wean pediatric ARDS patients: a physiologic crossover study date: 2020-07-07 words: 4276 flesch: 34 summary: The aim of this physiological single center, nonblinded, crossover study was to assess the effects of NAVA versus Pressure Support Ventilation (PSV) on patient-ventilator interaction in pediatric patients with difficulty in weaning from mechanical ventilation after moderate PARDS Pediatric patients, especially after acute respiratory failure, present high respiratory rates, small tidal volumes, and strong inspiratory efforts. keywords: nava; patients; pediatric; pressure; psv; study; time; ventilation; ventilatory cache: cord-028709-r1inj3ra.txt plain text: cord-028709-r1inj3ra.txt item: #532 of 2876 id: cord-028721-x6f26ahr author: Nistal, Manuel title: Non-neoplastic diseases of the testis date: 2020-06-22 words: 78262 flesch: 36 summary: 1116 Other tumors reported in patients with Klinefelter's syndrome (lymphoma, leukemia, bronchogenic carcinoma, urothelial carcinoma of the bladder, adrenal carcinoma, prostatic adenocarcinoma, testicular Leydig cell tumor, and epidermoid cyst) do not appear to have a higher incidence than in the general population. Sertoli cell-only syndrome with immature Sertoli cells Sertoli cells in adult testes with this variant of Sertoli cell-only syndrome have an immature prepubertal appearance with pseudostratifi cation. keywords: absence; adrenal; adult; age; albuginea; androgen; anomalies; atrophy; azoospermia; bilateral; cases; cause; cell hyperplasia; cell tumor; chromosome; ciency; cord; cryptorchidism; cystic; defi; development; diagnosis; disease; epididymis; epithelium; failure; fi ndings; fig; form; fsh; gene; germ cells; gonadal; hormone; human; hyperplasia; hypogonadism; incidence; infertility; klinefelter; levels; leydig cells; low; male; maturation; men; mutation; müllerian; normal; number; obstruction; orchitis; patients; present; puberty; receptor; report; rete testis; sertoli cells; serum; sex; spermatids; spermatogenesis; spermatogonia; spermatozoa; studies; study; syndrome; testes syndrome; testicular; testicular atrophy; testicular biopsy; testicular cancer; testicular descent; testicular dysgenesis; testicular function; testicular germ; testicular lesions; testicular microlithiasis; testicular parenchyma; testicular torsion; testicular tumor; testis; testis testicular; testosterone; tissue; treatment; tubular; tubules; tunica; type cache: cord-028721-x6f26ahr.txt plain text: cord-028721-x6f26ahr.txt item: #533 of 2876 id: cord-028907-m9psxg1f author: Li, Yi title: Extended antiplatelet therapy with clopidogrel alone versus clopidogrel plus aspirin after completion of 9- to 12-month dual antiplatelet therapy for ACS patients with both high bleeding and ischemic risk. Rationale and design of the OPT-BIRISK double blinded, placebo controlled randomized trial date: 2020-07-09 words: 3545 flesch: 33 summary: In order to test this hypothesis, we designed the Optimal antiPlatelet Therapy for high Bleeding and Ischemic RISK patients (OPT-BIRISK) trial, to determine if extended clopidogrel monotherapy will be superior to DAPT with clopidogrel and aspirin following completion of 9 to 12 months DAPT for ACS patients who received drug eluting stent (DES) implantation and possess both high bleeding and high ischemic characteristics. Different from the above studies, TWILIGHT and OPT-BIRISK are both double blinded trials focused on high risk patients, and the high risk criteria of these two trials partly overlap. keywords: antiplatelet; bleeding; dapt; patients; risk; therapy cache: cord-028907-m9psxg1f.txt plain text: cord-028907-m9psxg1f.txt item: #534 of 2876 id: cord-028982-kkzpqbry author: Sahu, Dipit title: Telerehabilitation during COVID 19: Shoulder rehabilitation date: 2020-07-10 words: 426 flesch: 30 summary: Both self-rehabilitation and telerehabilitation have shown good results in patients who have 30 undergone either shoulder surgery or conservative therapy for shoulder fractures Telerehabilitation has been proven to produce good functional results, lower pain scores and high 32 patient satisfaction in patients with conservatively treated fracture of proximal humerus and also 33 in patients after shoulder arthroplasty [4] . keywords: patients; telerehabilitation cache: cord-028982-kkzpqbry.txt plain text: cord-028982-kkzpqbry.txt item: #535 of 2876 id: cord-029112-u507i0t0 author: Smith, Keisha title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 words: 20949 flesch: 39 summary: While the Investigator is not obligated to actively seek this information in former study patients, he or she may learn of an SAE through spontaneous reporting. key: cord-029112-u507i0t0 authors: Smith, Keisha; Pace, Amy; Ortiz, Stephan; Kazani, Shamsah; Rottinghaus, Scott title: A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trial date: 2020-07-13 journal: Trials DOI: 10.1186/s13063-020-04548-z sha: doc_id: 29112 cord_uid: u507i0t0 OBJECTIVES: keywords: acute; alexion; alxn1210; amendment; bsc; complement; cov-305; covid-19; data; day; global; infection; information; infusion; intervention; investigator; lung; medical; patients; period; pregnancy; protocol; ravulizumab; sae; safety; study; time; treatment cache: cord-029112-u507i0t0.txt plain text: cord-029112-u507i0t0.txt item: #536 of 2876 id: cord-029150-e242o2ml author: Du, Jiang title: Expert consensus on the prevention and treatment of substance use and addictive behaviour-related disorders during the COVID-19 pandemic date: 2020-07-08 words: 4258 flesch: 28 summary: The treatment of comorbid physical and mental illnesses often requires the deployment of alternative addiction treatments. In addition, certain circumstances will make treatment of such patients difficult, including isolation management, fear of being infected when going out to take medication, conscious avoidance of treatment and complications of the medication process under pandemic conditions. keywords: addiction; covid-19; mental; pandemic; patients; problems; risk; substance; treatment; use cache: cord-029150-e242o2ml.txt plain text: cord-029150-e242o2ml.txt item: #537 of 2876 id: cord-029183-3aotgq6m author: Monard, Céline title: Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia date: 2020-07-14 words: 5860 flesch: 30 summary: Therefore, in pneumonia patients, international guidelines state that an attempt should be made to obtain respiratory samples and recommend to start early empirical treatment while awaiting for the results of culture and antimicrobial susceptibility testing (AST) Second, although we included a large panel of pneumonia patients (severe ICU patients with VAP or HAP and non-severe CAP patients from the emergency room), it remains unclear what group of patients will benefit most from the syndromic rm-PCR diagnosis. keywords: antibiotic; committee; culture; episodes; pathogens; patients; pcr; pneumonia; results; therapy cache: cord-029183-3aotgq6m.txt plain text: cord-029183-3aotgq6m.txt item: #538 of 2876 id: cord-029211-6o7qn2y2 author: None title: Press review date: 2020-07-15 words: 6214 flesch: 50 summary: Patients with digestive symptoms had a significantly longer time from onset to admission than patients without digestive symptoms (9.0 days vs 7.3 days). Patients age 18 years and older with T2T3 low rectal cancer, of maximum size 4 cm, who were clinically good responders after chemoradiotherapy (residual tumour ≤ 2 cm) were randomly assigned before surgery to either local excision or total mesorectal excision. keywords: group; icg; lymph; patients; rate; resection; study; surgery; survival cache: cord-029211-6o7qn2y2.txt plain text: cord-029211-6o7qn2y2.txt item: #539 of 2876 id: cord-029332-yn603pvb author: None title: Full Issue PDF date: 2020-07-15 words: 11336 flesch: 34 summary: To recognize cardiovascular complications among COVID-19 patients. We are also learning that acute kidney injury is quite prevalent and highly associated with mortality in COVID-19 patients (6). keywords: acute; cardiac; cardiovascular; care; case; china; coronavirus; covid-19; diagnosis; disease; dysfunction; failure; figure; heart; history; infection; mortality; myocarditis; pandemic; patients; pneumonia; risk; sars; syndrome cache: cord-029332-yn603pvb.txt plain text: cord-029332-yn603pvb.txt item: #540 of 2876 id: cord-029466-9sy6icrm author: Ramadan, Ahmad Riad title: Tales of a department: how the COVID-19 pandemic transformed Detroit’s Henry Ford Hospital, Department of Neurology—part I: the surge date: 2020-07-12 words: 4350 flesch: 47 summary: With the ensuing reduction in our NICU census and everincreasing demand to staff COVID-19 medical units, we volunteered a lean rounding model in our unit, allowing our rotating trainees to be deployed to the ED or COVID-19 ICUs. They also had 10 days off between COVID-19 unit rotations to recuperate. keywords: care; covid-19; department; health; march; medical; neurology; pandemic; patients; research; residents; staff; unit cache: cord-029466-9sy6icrm.txt plain text: cord-029466-9sy6icrm.txt item: #541 of 2876 id: cord-029547-9ei1ram3 author: Li, Jingwei title: The epidemiology and therapeutic options for the COVID-19 date: 2020-05-28 words: 7859 flesch: 39 summary: Then, the quantity of COVID-19 patients increased rapidly after Chinese New Year. According to the data collected in January 2020, the incubation stage of COVID-19 patients ranges between 2 and 14 days, and its average is about 5 days (95% credible interval: 4.2-6.0) when implementing the best-fit lognormal distribution. keywords: cells; characteristics; china; clinical; coronavirus; cov-2; covid-19; disease; infection; novel; patients; pneumonia; sars; symptoms; treatment; vaccine cache: cord-029547-9ei1ram3.txt plain text: cord-029547-9ei1ram3.txt item: #542 of 2876 id: cord-029606-2z1tw4xo author: John, Janice title: Developing an Intensive Community Covid-19 Management Strategy: Helping Our Patients Access Patient-Centered Care across a Continuum of Covid-19 Disease Needs date: 2020-05-27 words: 3164 flesch: 45 summary: Yet, to optimally manage resources, telemedicine needs to be optimized to assess Covid-19 patients, and needs to be coordinated with in-person evaluation and a population health management approach to ensure the safety of patients. These providers are organized in two teams that take on panels of suspected and confirmed Covid-19 patients who are at higher risk for severe disease. keywords: care; clinic; community; covid-19; disease; management; patients cache: cord-029606-2z1tw4xo.txt plain text: cord-029606-2z1tw4xo.txt item: #543 of 2876 id: cord-029609-zh2ah34g author: Hamilton, Barbara C.S. title: Developing Perioperative Covid-19 Testing Protocols to Restore Surgical Services date: 2020-06-19 words: 3165 flesch: 36 summary: The group continued to be the steward of all major Covid-19 perioperative decision and determined to implement its SARS-CoV-2 testing procedure for surgical patients in a stepwise manner to account for practical conditions that blocked a full rollout on a single date. With the unresolved uncertainties in the supply chain (for reagents and nasal swabs, for example) and that asymptomatic testing for surgical patients would add between 50 and 250 patients (normal daily volumes), we recognized that full implementation had the potential to quickly overwhelm the testing system. keywords: care; communication; covid-19; operating; patients; surgery; testing cache: cord-029609-zh2ah34g.txt plain text: cord-029609-zh2ah34g.txt item: #544 of 2876 id: cord-029612-cts1al9z author: Kaplan, Alan title: COVID-19 and Healthcare's Productivity Shock date: 2020-06-15 words: 2591 flesch: 39 summary: Pre-crisis, a man in his mid-50s with difficulty urinating would generate practice revenue through a billable office visit, a blood draw to rule out prostate cancer, urinalysis to rule out infection and uroflowmetry to diagnose urinary obstruction. While most industries face periodic downturns, hospital revenue has grown by at least 3% in every year since 1965, according to National Health Expenditure data from the Centers for Medicare and Medicaid Services. keywords: care; covid-19; health; hospitals; patient; practices; revenue cache: cord-029612-cts1al9z.txt plain text: cord-029612-cts1al9z.txt item: #545 of 2876 id: cord-029615-x498xj3m author: Kim, Michelle Kang title: A Primer for Clinician Deployment to the Medicine Floors from an Epicenter of Covid-19 date: 2020-05-04 words: 2916 flesch: 37 summary: At night, cross-coverage was best performed by non-internal medicine providers, completing tasks set forth by the day team, while internal medicine-trained providers were responsible for admitting new patients. Care teams consisted of two FLPs and an attending, with groups of three to four teams overseen by an SH. keywords: care; deployment; hospital; inpatient; medicine; patient; providers; teams cache: cord-029615-x498xj3m.txt plain text: cord-029615-x498xj3m.txt item: #546 of 2876 id: cord-029626-j6b59y7a author: Cooley, Laura title: Fostering Human Connection in the Covid-19 Virtual Health Care Realm date: 2020-05-20 words: 1515 flesch: 37 summary: Patients cite the ease with which they can discuss personal problems when mediated by technology.9 In addition, these virtual home visits allow patients to avoid traveling to a clinical setting or waiting there with frustration for a provider who runs late. American Hospital Association Issue Brief Pandemic creates opportunity for telehealth to catch on, WBUR News Dean of Stanford Medicine: how virtual care can make medicine even more human The transition from reimagining to recreating health care is now Tele-trust: what is telemedicine's impact on the physician-patient relationship? keywords: care; communication; covid-19; health; patients cache: cord-029626-j6b59y7a.txt plain text: cord-029626-j6b59y7a.txt item: #547 of 2876 id: cord-029770-72ncfyc5 author: Farasat, Sadaf title: Sleep and Delirium in Older Adults date: 2020-07-27 words: 5911 flesch: 23 summary: Bedside staff (i.e., nurses) can complete the RCSQ on their patients' behalf, but have been shown to overestimate patient sleep quality [97] ; hence, proxy completion should be performed with caution. In older hospitalized adults, sleep quality is particularly poor, averaging 2.5 fewer hours than home [50] . keywords: adults; care; delirium; hospital; icu; interventions; melatonin; patients; quality; review; risk; sleep; study; unit cache: cord-029770-72ncfyc5.txt plain text: cord-029770-72ncfyc5.txt item: #548 of 2876 id: cord-029848-dj5xqlz1 author: Mahajan, Vidushi title: Using Telemedicine During the COVID-19 Pandemic date: 2020-05-14 words: 2136 flesch: 45 summary: Since children represent a vulnerable population, detailed guidance on the delivery of primary and emergent care via telemedicine services is the need of the hour. With the issue of telemedicine practice guidelines under the Indian Medical Council Act, 1956, medical practitioners are now empowered and legally protected to provide telemedicine services according to guidelines stated [2] . keywords: care; health; medical; patient; services; telemedicine cache: cord-029848-dj5xqlz1.txt plain text: cord-029848-dj5xqlz1.txt item: #549 of 2876 id: cord-029859-fhm0d9t9 author: Yue, Ling title: How psychiatrists coordinate treatment for COVID-19: a retrospective study and experience from China date: 2020-07-21 words: 2948 flesch: 38 summary: Patients with mental health disorders in the COVID-19 epidemic Anxiety, depression and somatic symptoms in COVID-19 patients Care for critically ill patients with COVID-19 Systematic review of psychological first aid Psychological crisis intervention during the outbreak period of new coronavirus pneumonia from experience in Shanghai Comprehensive treatment and management of corona virus disease 2019: The psychiatric diagnoses for the 84 patients with COVID-19 who used mental health consultation were as follows: acute stress reaction (39.3%), sleep disorders (33.3%), anxiety state (15.5%), depression state or major depression (7.1%), and delirium (4.8%) (see table 4 ). keywords: consultation; covid-19; health; mental; patients; psychiatric cache: cord-029859-fhm0d9t9.txt plain text: cord-029859-fhm0d9t9.txt item: #550 of 2876 id: cord-029884-zl0uqmfi author: Horowitz, Robert K. title: MVP (Medical situation, Values and Plan): A memorable and useful model for all Serious Illness Conversations date: 2020-07-30 words: 3487 flesch: 46 summary: A Framework for Goals of Care Conversations Feasibility and Effectiveness of a Mnemonic Approach to Teach Residents How to Assess Goals of Care The Complete Guide to Communication Skills in Clinical Practice From Theory to Practice: The Application of Cognitive Load Theory to the Practice of Medicine Mnemonic Devices and Memory Schemas Working Memory: The Interface between Memory and Cognition Working memory From Cognitive Load Theory to Collaborative Cognitive Load Theory Discussing life expectancy with terminally ill cancer patients and their carers: a qualitative study Factors considered important at the end of life by patients, family, physicians, and other care providers Relationship between cancer patients' predictions of prognosis and their treatment preferences End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences Physicians recommend different treatments for patients than they would choose for themselves Defining Advance Care Planning for Adults: A Consensus Definition From a Multidisciplinary Delphi Panel Value Awareness: A New Goal for End-of-life Decision Making Patients who make wrong choices Misunderstandings about prognosis: an approach for palliative care consultants when the patient does not seem to understand what was said The existential plight in cancer: significance of the first 100 days Autonomy, liberalism and advance care planning Patient autonomy and advance care planning: a qualitative study of oncologist and palliative care physicians' perspectives Dying in the hospital setting: A systematic review of quantitative studies identifying the elements of end-of-life care that patients and their families rank as being most important Underlying goals of advance care planning (ACP): a qualitative analysis of the literature Effect of Palliative Care-Led Meetings for Families of Patients With Chronic Critical Illness: A Randomized Clinical Trial Missed opportunities for advance care planning communication during outpatient clinic visits Enhancing physician-patient communication Patients' trust in physicians: many theories, few measures, and little data Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment Drug therapy of anxiety and fear in palliative care patients with cancer or other illnesses. MVP is also iterative, since many SICs will not achieve clarity and closure in a single cycle, but rather over a series 4 of them, depending on clinical urgency, patient and family age, developmental and attentional factors, and participants' time-, cognitive-, and emotional-resources. keywords: care; medical; mvp; patient; plan; values cache: cord-029884-zl0uqmfi.txt plain text: cord-029884-zl0uqmfi.txt item: #551 of 2876 id: cord-029991-0sy417j0 author: Longhini, Federico title: Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study date: 2020-08-03 words: 4621 flesch: 34 summary: Compared to T0, ΔEELI significantly increased in hypersecretive patients at T2 and T3, irrespective of the RM; on the contrary, no differences were observed in normosecretive patients. Hypersecretive patients showed higher ΔEELI at T2 and T3, as opposed to the respective time points in normosecretive patients (Table 2 ; Fig. 2 ). keywords: airway; application; chest; data; hfcwo; hypersecretive; impedance; lung; patients; study; ventilation cache: cord-029991-0sy417j0.txt plain text: cord-029991-0sy417j0.txt item: #552 of 2876 id: cord-030149-hkpjnqm9 author: Fioratti, Iuri title: Strategies for a safe and assertive telerehabilitation practice date: 2020-08-07 words: 1805 flesch: 18 summary: Eleven consistent recommendations from high-quality clinical practice guidelines: systematic review The taxonomy of telemedicine Definitions of terms in telehealth An E-Pain intervention to spread modern pain education in Brazil Patients' experiences of telerehabilitation at home after shoulder joint replacement Effectiveness of an internet-delivered exercise and pain-coping skills training intervention for persons with chronic knee pain: a randomized trial Patients' needs and requirements for eHealth pain management interventions: Qualitative study Patient acceptance of a telemedicine service for rehabilitation care: a focus group study Experiences of a web-based nursing intervention-interviews with women with chronic musculoskeletal pain Attitudes towards the use and acceptance of eHealth technologies: a case study of older adults living with chronic pain and implications for rural healthcare Understanding factors affecting patient and public engagement and recruitment to digital health interventions: a systematic review of qualitative studies Predictors of communication preferences in patients with chronic low back pain People with low back pain want clear, consistent and personalised information on prognosis, treatment options and self-management strategies: a systematic review Enhancing communication skills for telehealth: development and implementation of a Teach-Back intervention for a national maternal and child health helpline in Australia Telephone cognitive behavioural therapy to prevent the development of chronic widespread pain: a qualitative study of patient perspectives and treatment acceptability Self-management of chronic low back pain: An exploration of the impact of a patientcentered website Managing patients with chronic pain during the COVID-19 outbreak: considerations for the rapid introduction of remotely supported (eHealth) pain management services How, when and why people seek health information online: qualitative study in Hong Kong Feasibility of applied gaming during interdisciplinary rehabilitation for patients with complex chronic pain and fatigue complaints: a mixed-methods study Adherence to a web-based physical activity intervention for patients with knee and/or hip osteoarthritis: a mixed method study Van Gaal BGI. But it worked really well: a qualitative study of patient perceptions of telephone-delivered exercise therapy by physiotherapists for people with knee osteoarthritis Patient participation in chronic pain management through social media: a clinical study Brazil b Centre for Pain, Health and Lifestyle, Brazil c Department of Physical Therapy keywords: information; pain; patients; physical; telerehabilitation; use cache: cord-030149-hkpjnqm9.txt plain text: cord-030149-hkpjnqm9.txt item: #553 of 2876 id: cord-030216-l38i06v2 author: Liao, Kuang-Ming title: Hospital costs and prognosis in end-stage renal disease patients receiving coronary artery bypass grafting date: 2020-08-08 words: 3712 flesch: 41 summary: [22] analyzed mortality risk factors in Asian ESRD patients and reported that in ESRD patients with cardiovascular disease, stroke was a significant risk factor in all-cause mortality, while diabetes and hs-CRP were significant risk factors in all-cause mortality in ESRD patients without cardiovascular disease. Most studies comparing ESRD patients receiving coronary artery bypass grafting (CABG) or percutaneous coronary intervention have found that the long-term survival is good in ESRD patients after CABG. keywords: cabg; disease; esrd; mortality; non; patients; risk; study cache: cord-030216-l38i06v2.txt plain text: cord-030216-l38i06v2.txt item: #554 of 2876 id: cord-030254-eevqclsy author: Mehta, Chitra title: Management of Coronavirus 2019 date: 2020-04-24 words: 4039 flesch: 51 summary: 14 The initial approach should be early suspicion, early recognition, immediate isolation, and institution of infection control precautions of COVID-19 patients. The use of acetaminophen or paracetamol over other antipyretics is recommended for temperature control in COVID-19 patients. keywords: coronavirus; cov-2; covid-19; days; disease; infection; patients; risk; sars; use cache: cord-030254-eevqclsy.txt plain text: cord-030254-eevqclsy.txt item: #555 of 2876 id: cord-030256-muah207b author: Kapoor, Poonam Malhotra title: COVID-19 Thrombosis: An Unsolved Mystery date: 2020-07-24 words: 1651 flesch: 42 summary: It is widely acknowledged that the majority of COVID-19 patients, especially those with severe disease, are characterized by lymphocytopenia. COVID-19: consider cytokine storm syndromes and immunosuppression Current concepts in the diagnosis and management of cytokine release syndrome Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia COVID-19 ECMO myths busted United States Center for Disease Control interim guidance for clinical management of COVID-19 patients with and without acute respiratory distress syndrome Intubation and ventilation amid the COVID-19 outbreak: Wuhan's experience keywords: cells; covid-19; cytokine; ecmo; patients; syndrome; virus cache: cord-030256-muah207b.txt plain text: cord-030256-muah207b.txt item: #556 of 2876 id: cord-030361-0tepkjdl author: Mohammed Abdul, Mubeen Khan title: Hepatitis C Virus in the Elderly in the Direct-Acting Antiviral Era: from Diagnosis to Cure date: 2020-08-11 words: 4999 flesch: 39 summary: IDSA HCV guidance: recommendations for testing, managing, and treating hepatitis C Viral hepatitis in older adults Hepatitis C virus infection in the older patient Fibrosis in patients with chronic hepatitis C: detection and significance Treating Medicaid patients with hepatitis C: clinical and economic impact Health state utilities and quality of life in hepatitis C patients Hepatitis C virus and metabolic disorder interactions towards liver damage and atherosclerosis Assessment of fatigue in patients with chronic hepatitis C using the fatigue impact scale Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C Safety and efficacy of ledipasvir/ sofosbuvir for the treatment of genotype 1 hepatitis C in subjects aged 65 years or older Safety and efficacy of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C in patients aged 65 years or older Safety and efficacy of sofosbuvir/ velpatasvir for the treatment of chronic hepatitis C in patients aged 65 years or older: a retrospective analysis of phase 3 studies Efficacy and safety of elbasvir/grazoprevir in hepatitis C virus GT1-and GT4-infected people aged 65 years or older Directacting antivirals are effective for chronic hepatitis C treatment in elderly patients: A real-world study of 17,487 patients DAAs produce high rates of SVR in all age groups Interferon-free therapy in elderly patients with advanced liver diseas SVR rates with interferon-free regimens in elderly patients are high and comparable to the general population Safety and efficacy of direct-acting antivirals for the treatment of chronic hepatitis C in a real-world population aged 65 years and older Efficacy and safety of direct-acting antivirals for hepatitis C in the elderly: a systematic review and meta-analysis Direct-acting antivirals for HCV treatment in older patients: a systematic review and meta-analysis The efficacy and safety of direct acting antiviral treatment and clinical significance of drug-drug interactions in elderly patients with chronic hepatitis C virus infection Histological outcome during long-term lamivudine therapy A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis Reversal of fibrosis in patients with nonalcoholic steatohepatosis after gastric bypass surgery Long-term liver stiffness assessment in hepatitis C virus patients undergoing antiviral therapy: Results from a 5-year cohort study Care of patients following cure of hepatitis C virus infection Incidence of hepatocellular carcinoma in patients with HCV-associated cirrhosis treated with direct-acting antiviral agents HCV eradication induced by direct-acting antiviral agents reduces the risk of hepatocellular carcinoma Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients Treatment of elderly patients with chronic hepatitis C: a retrospective cohort study Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Who Rising mortality associated with hepatitis C virus in the United States Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965 Centers for Disease Control and Prevention initiatives to prevent hepatitis C virus infection: a selective update Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups Progression to cirrhosis in hepatitis C patients: an agedependent process Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: A cross sectional and longitudinal study Implementation of a large system-wide hepatitis C virus screening and linkage to care program for baby boomers Hepatitis C treatment in the elderly: new possibilities and controversies towards interferonfree regimens Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection Grazoprevir-Elbasvir combination therapy for treatment-naive cirrhotic and noncirrhotic patients with chronic hepatitis C virus genotype 1, 4, or 6 infection: a randomized trial Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis Sofosbuvir and velpatasvir for hcv genotype 1, 2, 4, 5, and 6 infection The changing epidemiology of hepatitis C virus infection in the United States: National health and nutrition examination survey, through 2010 OUtcomes of treatment for hepatitis c virus infection by providers Improving veteran access to treatment for hepatitis C virus infection AASLD/ keywords: chronic; cirrhosis; daa; drug; hcv; hepatitis; patients; regimens; treatment; years cache: cord-030361-0tepkjdl.txt plain text: cord-030361-0tepkjdl.txt item: #557 of 2876 id: cord-030369-4dn02a35 author: Peng, Liang title: Clinical Manifestations and Laboratory Tests of AECHB and Severe Hepatitis (Liver Failure) date: 2019-05-21 words: 35873 flesch: 36 summary: Of the possible complications occurring in liver failure patients, bleeding is the most common and severe. Concomitant infection in liver failure patients has the following characteristics: (1) a high incidence; (2) infection may occur at different sites either simultaneously or sequentially, and abdominal and biliary tract infection is the most common. keywords: aclf; acute; acute hepatitis; alf; bilirubin; blood; cause; changes; chronic; chronic hepatitis; cirrhosis; clinical; diagnosis; encephalopathy; factors; failure patients; gene; hbv; hbv infection; hepatic; hepatitis; hepatitis patients; immune; infection; liver cells; liver cirrhosis; liver damage; liver disease; liver failure; liver function; liver injury; liver transplantation; mutation; necrosis; patients; prognosis; protein; serum; severity; stage; studies; study; therapy; treatment; type; type hepatitis; type patients; virus cache: cord-030369-4dn02a35.txt plain text: cord-030369-4dn02a35.txt item: #558 of 2876 id: cord-030370-89n13hml author: Brown, Colin S. title: Ebola Virus Disease in the Obstetric Population date: 2019-04-11 words: 17490 flesch: 44 summary: The risk of fluid overload must be balanced with the propensity of EVD patients to be fluid depleted and anuric. Given the overwhelming benefit to breastfeeding, particularly in resource-poor settings, current CDC guidelines support routine breastfeeding of the neonate born to EVD survivors, with case-by-case evaluation to neonates born to suspect or confirmed EVD patients [73] . keywords: african; care; case; children; delivery; disease; ebola; ebola virus; epidemic; evd; health; infection; leone; management; outbreak; patient; red; risk; screening; sierra; staff; symptoms; treatment; virus; west; zone cache: cord-030370-89n13hml.txt plain text: cord-030370-89n13hml.txt item: #559 of 2876 id: cord-030380-okue1kso author: McWilliams, J. Michael title: Professionalism Revealed: Rethinking Quality Improvement in the Wake of a Pandemic date: 2020-07-22 words: 5913 flesch: 38 summary: Conceptually, with informed and motivated professionals as their agents, patients effectively become discerning consumers capable of driving healthy competition in health care markets where extrinsic pressure may be needed to encourage highquality care (e.g., primary care physicians [PCPs] directing patients to the safest hospitals or surgeons selecting the best devices). An International Comparison The Social Transformation of American Medicine: The Rise of a Sovereign Profession and the Making of a Vast Industry Structuring Incentives Within Organizations: The Case of Accountable Care Organizations Using behavioral economics to design physician incentives that deliver high-value care Physician peer comparisons as a nonfinancial strategy to improve the value of care Information and quality when motivation is intrinsic: evidence from surgeon report cards Assessing the effectiveness of peer comparisons as a way to improve health care quality Effect of an automated patient dashboard using active choice and peer comparison performance feedback to physicians on statin prescribing: the PRESCRIBE cluster randomized clinical trial Effect of behavioral interventions on inappropriate antibiotic prescribing among primary care practices: a randomized clinical trial Effect of an outpatient antimicrobial stewardship intervention on broad-spectrum antibiotic prescribing by primary care pediatricians: a randomized trial Provision of social norm feedback to high prescribers of antibiotics in general practice: a pragmatic national randomised controlled trial Effect of peer comparison letters for highvolume primary care prescribers of quetiapine in older and disabled adults: a randomized clinical trial Patient mortality during unannounced accreditation surveys at US hospitals The author thanks Thomas McGuire, Leemore Dafny, Mark Friedberg, Tim Layton, Michael Chernew, Adam Beckman, and three anonymous referees for helpful comments on an earlier draft. keywords: care; clinicians; health; improvement; incentives; measures; organizations; patients; performance; physicians; professionalism; quality cache: cord-030380-okue1kso.txt plain text: cord-030380-okue1kso.txt item: #560 of 2876 id: cord-030502-mvlib8ol author: Hatachi, Takeshi title: Early steroid pulse therapy among children with influenza virus-associated encephalopathy date: 2020-08-12 words: 4274 flesch: 40 summary: Confidence interval Acute encephalopathy associated with influenza and other viral infections Encephalopathy associated with influenza epidemics Pediatric neurological complications of 2009 pandemic influenza A (H1N1) Acute childhood encephalitis and encephalopathy associated with influenza: a prospective 11-year review Neurological manifestations of influenza infection in children and adults: results of a National British Surveillance Study Influenza-associated encephalitis/encephalopathy identified by the Australian Childhood Encephalitis Study Fatal viral infectionassociated encephalopathy in two Chinese boys: a genetically determined risk factor of thermolabile carnitine palmitoyltransferase II variants Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes National surveillance of influenza-associated encephalopathy in Japan over six years, before and during the 2009-2010 influenza pandemic Characteristics and outcomes of influenza-associated encephalopathy cases among children and adults in Japan The puzzling picture of acute necrotizing encephalopathy after influenza A and B virus infection in young children Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy Elevated serum levels of neutrophil elastase in patients with influenza virusassociated encephalopathy Predictive value of serum interleukin-6 level in influenza virus-associated encephalopathy The specific therapy for influenza encephalopathy in Japan Guideline for the management of influenza associated encephalopathy Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin Prognostic factors for acute encephalopathy with bright tree appearance Prediction of acute encephalopathy with biphasic seizures and late reduced diffusion in patients with febrile status epilepticus Validity of diagnoses, procedures, and laboratory data in Japanese administrative data The eye response test alone is sufficient to predict stroke outcome-reintroduction of Japan Coma Scale: a cohort study Constructing a control group using multivariate matched sampling methods that incorporate the propensity score Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies Encephalitis and encephalopathy associated with an influenza epidemic in Japan Acute encephalopathy and encephalitis caused by influenza virus infection Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy Prostaglandin E2: the villain in the host response to influenza virus The hidden burden of influenza: a review of the extra-pulmonary complications of influenza infection. key: cord-030502-mvlib8ol authors: Hatachi, Takeshi; Michihata, Nobuaki; Takeuchi, Muneyuki; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo title: Early steroid pulse therapy among children with influenza virus-associated encephalopathy date: 2020-08-12 journal: J Intensive Care DOI: 10.1186/s40560-020-00479-8 sha: doc_id: 30502 cord_uid: mvlib8ol BACKGROUND: keywords: encephalopathy; iae; influenza; patients; pulse; steroid; therapy cache: cord-030502-mvlib8ol.txt plain text: cord-030502-mvlib8ol.txt item: #561 of 2876 id: cord-030531-4uucx9ss author: Randremanana, Rindra Vatosoa title: An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial date: 2020-08-17 words: 8052 flesch: 45 summary: The routine samples taken from trial patients will be labelled with a collection label which will not contain a patient trial identifier. The majority of plague patients are treated at the CSB level. keywords: bubonic; ciprofloxacin; clinical; daily; data; days; patients; plague; pneumonic; protocol; streptomycin; study; treatment; trial cache: cord-030531-4uucx9ss.txt plain text: cord-030531-4uucx9ss.txt item: #562 of 2876 id: cord-030897-c88tjrai author: Aljohani, Amal H. title: Clinical and Immunological Characterization of Combined Immunodeficiency Due to TFRC Mutation in Eight Patients date: 2020-08-27 words: 3490 flesch: 49 summary: A retrospective review of clinical and immunological features of patients diagnosed with a TFRC gene mutation between 2015 and 2019 in three tertiary centers. This report provides a large cohort with a long follow up of patients with this disease. keywords: cells; gene; iron; patients; receptor; tfr1; tfrc; transferrin cache: cord-030897-c88tjrai.txt plain text: cord-030897-c88tjrai.txt item: #563 of 2876 id: cord-030918-0w327dgj author: Praena Crespo, Manuel title: Patient-centered primary care pediatrics. Is a paradigm change needed?() date: 2020-08-27 words: 1315 flesch: 38 summary: Strategic Line 3 emphasises the importance of continuity of care, promoting teamwork and delegation of responsibilities, avoiding duplicate interventions and facilitating the transition between levels of care, while Strategic Line 4 highlights the 'reorientation of health care' to the needs of each patient and the delivery of interventions to address those needs, using indicators such as the AMGs used in the study by Barrio et al. 2 This work is relevant in that it proposes identification of patients with chronic diseases, establishing their level of risk based on the volume of used services and the factors associated with it, thus providing objective data to guide the allocation of health care resources at both the macro level (public health departments, areas or health districts) and the micro level (primary care centres). keywords: care; diseases; health; patients cache: cord-030918-0w327dgj.txt plain text: cord-030918-0w327dgj.txt item: #564 of 2876 id: cord-030927-wo8r8zny author: Collins, Curtis D title: Perspectives from the frontline: A pharmacy department’s response to the COVID-19 pandemic date: 2020-06-22 words: 4478 flesch: 32 summary: A 32-bed overflow special pathogens unit, previously equipped for management of critical care patients during a disaster response, was opened. Pharmacists intervened to address a wide scope of medication-related issues, likely contributing to improved management of COVID-19 patients. keywords: antimicrobial; care; covid-19; interventions; management; pandemic; patients; pharmacists; pharmacy; study cache: cord-030927-wo8r8zny.txt plain text: cord-030927-wo8r8zny.txt item: #565 of 2876 id: cord-030962-2xem8inu author: Isea de la Viña, Jesus title: Lung cancer patients on the waiting list in the midst of the COVID-19 crisis: what do we do now?() date: 2020-08-28 words: 913 flesch: 50 summary: The authors concluded that cancer patients show deteriorating conditions and poor outcomes, and recommend that CB patients receiving antitumor therapy should undergo vigorous screening for COVID-19 infection 4,5 (clinical-epidemiological history, RT-PCR, serology), and that treatments that cause immunosuppression, including surgery, should be avoided. The American College of Surgeons (ACS), 1 in their recently published guidelines on the management of patients scheduled for thoracic surgery, categorize the general status of hospitals into 3 phases according to the number of COVID-19 patients admitted: phase 1 -preparation; phase 2 -urgent setting; and phase 3 -ଝ keywords: cancer; covid-19; patients cache: cord-030962-2xem8inu.txt plain text: cord-030962-2xem8inu.txt item: #566 of 2876 id: cord-031129-wqkdug42 author: Carr, Zyad J. title: An Update on Systemic Sclerosis and its Perioperative Management date: 2020-08-29 words: 4640 flesch: 21 summary: A common complication of scleroderma Risk factors for mortality and mortality rates in interstitial lung disease patients in the intensive care unit Outcome of patients with systemic sclerosis in the intensive care unit Risk factors for mortality and cardiopulmonary hospitalization in systemic Sclerosis patients at risk for pulmonary hypertension, in the PHAROS registry Clinical features and outcome of acute exacerbation in connective tissue disease-associated interstitial lung disease: a single-center study from India Lung-protective ventilation for the surgical patient: international expert panel-based consensus recommendations Combined femoral and sciatic nerve block in a cachectic progressive systemic sclerosis case with gastrointestinal and cardiac involvement The role of regional and neuroaxial anesthesia in patients with systemic sclerosis Neuroaxial anesthesia in a patient with progressive systemic sclerosis : case presentation and review of the literature on systemic sclerosis Spinal anesthesia for cesarean section in a patient with systemic sclerosis associated interstitial lung disease: a case report Spinal anaesthesia for caesarean section in a patient with systemic sclerosis Anesthetic management of a pregnant patient with scleroderma Prolonged regional analgesia in scleroderma Individuals with scleroderma may have increased risk of sleep-disordered breathing Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Experimental and Therapeutic Medicine Bisphosphonates and risk of cardiovascular events: a metaanalysis Dyspnea assessment and pulmonary hypertension in patients with systemic sclerosis: utility of the University of California Usefulness of six-minute walk test in systemic sclerosis Six-minute walk test in systemic sclerosis: a systematic review and meta-analysis A prospective, longitudinal study evaluating the baseline six-minute walk test as an individual reference value in systemic sclerosis patients Increased prevalence of small airways dysfunction in patients with systemic sclerosis as determined by impulse oscillometry. keywords: disease; ild; involvement; management; mortality; patients; risk; scleroderma; sclerosis; ssc; systemic cache: cord-031129-wqkdug42.txt plain text: cord-031129-wqkdug42.txt item: #567 of 2876 id: cord-031130-xvkyt3l3 author: Moreno-Duarte, Ingrid title: Heparin Induced Thrombocytopenia for the Perioperative and Critical Care Clinician date: 2020-08-29 words: 6027 flesch: 31 summary: Shorter courses of heparin treatment seem to decrease the risk of HIT development [13] . If surgery is urgent or emergent, bivalirudin is the recommended drug of choice [87] , although plasmapheresis or therapeutic plasma exchange (TPE) followed by heparin anticoagulation has been safely used at our institution for more than a decade in cardiac surgical operations that require systemic anticoagulation for cardiopulmonary bypass (Fig. 1) keywords: antibodies; cardiac; heparin; hit; patients; pf4; platelet; risk; surgery; thrombocytopenia; thrombosis; treatment cache: cord-031130-xvkyt3l3.txt plain text: cord-031130-xvkyt3l3.txt item: #568 of 2876 id: cord-031191-63xtga7h author: Barrios Espinosa, Cristian title: Recurrence of atrial fibrillation following non-cardiac surgery or acute illness: A common but rarely detected complication date: 2020-08-06 words: 1822 flesch: 33 summary: Although transient AF events, secondary to surgery or acute medical disease that revert before discharge have traditionally been considered benign, more recent evidence has associated secondary AF with increased risks of mortality, stroke, and AF recurrence [1, 8, 9] . [17] investigated the feasibility of selfmonitoring for AF recurrence in patients with secondary AF. keywords: fibrillation; patients; recurrence; surgery cache: cord-031191-63xtga7h.txt plain text: cord-031191-63xtga7h.txt item: #569 of 2876 id: cord-031256-4mxt501d author: Van Der Poorten, Marie-Line M. title: Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy. date: 2020-09-01 words: 1725 flesch: 50 summary: key: cord-031256-4mxt501d authors: Van Der Poorten, Marie-Line M.; Van Gasse, Athina L.; Hagendorens, Margo M.; Faber, Margaretha A.; De Puysseleyr, Leander; Elst, Jessy; Mertens, Christel M.; Romano, Antonino; Ebo, Didier G.; Sabato, Vito title: Non-irritating skin test concentrations for ceftazidime and aztreonam in patients with a documented beta-lactam allergy. This study aims at assessing the NIC for ceftazidime, a third generation cephalosporin, and 43 aztreonam, a synthetic monobactam, both potential safe alternative β-LABs in patients with a 44 documented hypersensitivity reaction to penicillin G, amoxicillin (+/-clavulanic acid) or cefazolin. keywords: aztreonam; patients cache: cord-031256-4mxt501d.txt plain text: cord-031256-4mxt501d.txt item: #570 of 2876 id: cord-031497-pp0p3en6 author: Rodríguez-Fuster, Alberto title: Tracheal trauma in the context of the current infection by COVID-19. About 2 cases() date: 2020-09-06 words: 1156 flesch: 47 summary: Guidelines from the Difficult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetists Expert recommendations for tracheal intubation in critically ill patients with noval coronavirus disease 2019 Recommendation of a practical guideline for safe tracheostomy during the COVID-19 pandemic CORONA-steps for tracheotomy in COVID-19 patients: A staff-safe method for airway management Guidance for wearing and removing personal protective equipment in healthcare settings for the care of patients with suspected or confirmed COVID-19 Tracheal trauma after difficult airway management in morbidly obese patients with COVID-19 [2] [3] [4] We report 2 cases of patients diagnosed with SARS-CoV-2 infection and tracheal iatrogenic rupture following airway manipulation. keywords: cases; patients; tracheal; tracheotomy cache: cord-031497-pp0p3en6.txt plain text: cord-031497-pp0p3en6.txt item: #571 of 2876 id: cord-031544-clzt6kyg author: Clavijo, Raul title: “Online” and “at-home” versus traditional models of health care: enhancing access or impeding optimal therapeutics? date: 2020-09-08 words: 4304 flesch: 28 summary: To effectively deliver reproductive health care through telehealth, we need to first improve user-centered design to optimize patient engagement. key: cord-031544-clzt6kyg authors: Clavijo, Raul; Ramasamy, Ranjith; Halpern, Joshua; Melnick, Alexis; Stewart, Joshua; Rosenwaks, Zev; Brannigan, Robert title: “Online” and “at-home” versus traditional models of health care: enhancing access or impeding optimal therapeutics? date: 2020-09-08 journal: keywords: access; care; fertility; health; home; online; patients; telehealth; telemedicine; testing; therapeutics cache: cord-031544-clzt6kyg.txt plain text: cord-031544-clzt6kyg.txt item: #572 of 2876 id: cord-031558-8wysernx author: Michas, Marta title: Factors influencing the implementation and uptake of a discharge care bundle for patients with acute exacerbation of chronic obstructive pulmonary disease: a qualitative focus group study date: 2020-08-21 words: 6200 flesch: 37 summary: The aim of this study was to explore and understand factors influencing implementation and uptake of COPD discharge care bundle items in acute care facilities from the perspective of health care providers and patients. Health care providers and patients identified four factors that can challenge the implementation of COPD discharge care bundles: process of care complexities, human capacity in care settings, communication and engagement, and attitudes and perceptions towards change. keywords: acute; bundle; care; copd; discharge; focus; groups; health; implementation; patients; providers cache: cord-031558-8wysernx.txt plain text: cord-031558-8wysernx.txt item: #573 of 2876 id: cord-031710-1xl2isee author: Andrei, Stefan title: Successful treatment of pulmonary haemorrhage and acute respiratory distress syndrome caused by fulminant Stenotrophomonas maltophilia respiratory infection in a patient with acute lymphoblastic leukaemia – case report date: 2020-09-10 words: 2586 flesch: 37 summary: Stenotrophomonas maltophilia-induced pulmonary haemorrhage is considered a fatal infection among haematological patients. Stenotrophomonas maltophilia severe pneumonia complicated with pulmonary haemorrhage is not always fatal in haematological patients. keywords: case; colistin; days; maltophilia; patient; stenotrophomonas; treatment cache: cord-031710-1xl2isee.txt plain text: cord-031710-1xl2isee.txt item: #574 of 2876 id: cord-031734-5wnvuk2n author: Wichlas, F. title: War surgery in Afghanistan: a model for mass causalities in terror attacks? date: 2020-09-11 words: 3123 flesch: 54 summary: The surgeons in these hospitals would have an incomparable amount of experience in treating war injuries. For this purpose, we analyzed the hospital resources, its management strategies, and the epidemiology of war injuries and their treatments. keywords: chest; hospital; injuries; patients; surgery; war cache: cord-031734-5wnvuk2n.txt plain text: cord-031734-5wnvuk2n.txt item: #575 of 2876 id: cord-031821-rywdkqcd author: Borregón Rivilla, Miguel title: Coronavirus infection in cancer patients, last update() date: 2020-09-12 words: 2137 flesch: 45 summary: If we look at many of the protocols for the diagnosis and treatment of patients with suspected or confirmed coronavirus infection, we observe that most cancer patients are classified as risk patients. key: cord-031821-rywdkqcd authors: Borregón Rivilla, Miguel; Martínez Barroso, Katherin Aly title: Coronavirus infection in cancer patients, last update() date: 2020-09-12 journal: Med Clin (Engl Ed) DOI: 10.1016/j.medcle.2020.05.021 sha: doc_id: 31821 cord_uid: rywdkqcd nan Editorial Coronavirus infection in cancer patients, last update Infección por coronavirus en pacientes oncológicos, evidencias a fecha de hoy. keywords: cancer; coronavirus; infection; patients; studies cache: cord-031821-rywdkqcd.txt plain text: cord-031821-rywdkqcd.txt item: #576 of 2876 id: cord-031907-ilhr3iu5 author: None title: ISEV2020 Abstract Book date: 2020-07-15 words: 201435 flesch: 40 summary: Normal pancreas cells (hTERT-HPNE and HPDE-H6c7) were co-cultured with cancer cell EVs for 24-48 hours. Before EV isolation cells were kept for 24 h either under normoxia or hypoxia (1% oxygen). keywords: ability; activation; activity; ad evs; addition; aim; analysis; analysis methods; anti; approach; assay; associated; bacterial evs; biological; biomarkers; blood; blood cells; blood evs; blot; bone; brain; breast; breast cancer; cancer cells; cancer evs; cancer introduction; cancer patients; cd63; cd81; cd9; cell communication; cell culture; cell evs; cell exosomes; cell function; cell lines; cell proliferation; cell surface; cell types; cells; cells introduction; changes; characterization; chromatography; composition; concentration; conclusion; conditions; content; control; control evs; cultured; current; cytometry; data; delivery; density; detection; development; diagnosis; differential; disease; distribution; dna; drug; effect; electron; endothelial; enrichment; epithelial; ev analysis; ev cargo; ev evs; ev isolation; ev markers; ev numbers; ev preparations; ev production; ev protein; ev release; ev research; ev rna; ev samples; ev subpopulations; ev surface; ev treatment; ev uptake; evs; exclusion; exosomal; exosomes; experiments; expression; expression analysis; extracellular; factors; findings; flow; fluorescent; fluorescent evs; fold; formation; fractions; free; function; funding; gene; group; growth; host cells; human; human evs; imaging; immune; increase; inflammation; inflammatory; introduction; isolated; isolation methods; key; large; levels; lipid; lung; macrophages; mass; mechanisms; media; medium; membrane; membrane vesicles; mesenchymal; metastasis; methods; mice; microscopy; migration; milk evs; mirna; model; molecular; molecules; mouse; msc evs; mscs; nanoparticle; national; neuronal; neurons; new; non; normal; novel; nta; number; particles; pathway; patients; plasma evs; plasma samples; platelet; platform; play; positive; positive evs; post; potential; presence; present; primary; process; production; profile; profiling; progression; proliferation; properties; prostate; prostate cancer; protein; protein cargo; protein expression; protein markers; proteomic; purification; purity; range; recipient cells; research; resistance; response; results; rna; rnas; role; samples; sec; secretion; sequencing; serum; sevs; signalling; single; size; small evs; specific; specific evs; spectrometry; stem cells; stromal cells; studies; study; summary; surface; system; target cells; targets; tau; techniques; tested; therapeutic; therapy; time; tissue; total; total evs; tracking; transfer; transmission; treatment; tumour cells; ultracentrifugation; university; uptake; urinary evs; urine; usa; usa introduction; use; vesicles; vesicles introduction; vitro; vivo; work cache: cord-031907-ilhr3iu5.txt plain text: cord-031907-ilhr3iu5.txt item: #577 of 2876 id: cord-032181-gmcugd8h author: Song, Jian-Xin title: Main Complications of AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 words: 51195 flesch: 34 summary: If liver disease patients have other lung diseases (such as chronic bronchitis, emphysema and pneumonia, and pleural effusion, etc.), then significant respiratory symptoms may occur. in liver cirrhosis patients with ascites that paracentesis should be performed after admission to determine whether SBP exist. keywords: acid; activity; acute; addition; ammonia; arterial; ascites; bacterial; bleeding; blood; body; brain; cause; cells; chronic; circulation; cirrhosis; coagulation; diagnosis; diseases; dysfunction; encephalopathy; endotoxin; factors; function; hepatic; hepatitis patients; high; hps; hps patients; hrs; hypoxemia; increase; infection; liver; liver cells; liver cirrhosis; liver disease; liver failure; liver function; liver transplantation; lps; manifestations; metabolic; oxygen; patients; plasma; platelet; pressure; protein; pulmonary; rate; receptor; renal; respiratory; role; serum; study; symptoms; syndrome; system; systemic; test; time; tract; treatment; type; vascular cache: cord-032181-gmcugd8h.txt plain text: cord-032181-gmcugd8h.txt item: #578 of 2876 id: cord-032183-yqqqe325 author: Ning, Qin title: Antiviral Therapy for AECHB and Severe Hepatitis B (Liver Failure) date: 2019-05-21 words: 32709 flesch: 39 summary: Survival analysis of 190 patients with HBV-related acuteon-chronic liver failure Does antiviral therapy reduce complications of cirrhosis? Hepatitis B-associated fibrosis and fibrosis/cirrhosis regression with nucleoside and nucleotide analogs Lamivudine treatment in patients with severely decompensated cirrhosis due to replicating hepatitis B infection Lamivudine for patients with chronic hepatitis B and advanced liver disease Determinants of early mortality in patients with decompensated chronic hepatitis B treated with antiviral therapy The role of lamivudine and predictors of mortality in severe flare-up of chronic hepatitis B with jaundice Meta-analysis of the short-term effects of lamivudine treatment for severe chronic hepatitis B Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B Adefovir dipivoxil therapy for lamivudine resistant hepatitis B in pre-and post-liver transplantation patients Long-term therapy with adefovir dipivoxil for HBeAg negative chronic hepatitis B for up to 5 years A comparison of entecavir and lamivudine for HBeAgpositive chronic hepatitis B Entecavir versus lamivudine for patients with HBeAgnegative chronic hepatitis B Entecavir versus lamivudine therapy for patients with chronic hepatitis B-associated liver failure: a meta-analysis Entecavir vs. lamivudine in chronic hepatitis B patients with severe acute exacerbation and hepatic decompensation The pros and cons of lamivudine vs. entecavir in decompensated or severe acute exacerbation of chronic hepatitis B Efficacy and safety of telbivudine therapy in liver failure patients with chronic hepatitis B virus infection Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment-naïve patients with HBV-related decompensated cirrhosis Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure The study of efficacy of lamivudine in patients with severe acute hepatitis B HBV-DNA suppression and disease course in HBV cirrhosis patients on long-term lamivudine therapy Clinical outcome of HBeAg-negative chronic hepatitis B in relation to virological response to lamivudine Long-term continuous entecavir therapy in nucleos(t) ide-naïve chronic hepatitis B patients Update in the management of chronic hepatitis B Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level United States Lamivudine Compassionate Use Study Group. In 64% of patients HBV DNA levels were detectable by the branched chain DNA assay. keywords: antiviral; b virus; chb; chb patients; chronic; chronic hepatitis; cirrhosis; combination; disease; entecavir; failure; group; hbeag; hbv; hbv dna; hcc; hepatitis b; ifn; immune; infection; lamivudine; liver; liver failure; liver transplantation; patients; rate; recurrence; resistance; response; risk; study; survival; therapy; transplantation; treatment; virus cache: cord-032183-yqqqe325.txt plain text: cord-032183-yqqqe325.txt item: #579 of 2876 id: cord-032244-s7t5u9lf author: Valente, Serafina title: ANMCO POSITION PAPER: Considerations on in-hospital cardiological consultations and cardiology outpatient clinics during the COVID-19 pandemic date: 2020-08-27 words: 1513 flesch: 26 summary: The reasons underlying the importance of COVID-19 infection for cardiologists are as follows: • It is a pandemic that affects everyone, especially cardiovascular patients, as shown by Chinese cases 2-6 ; • COVID-19 patients may have cardiovascular complications, although they are not so frequent 7, 8 ; • Cardiovascular disease continues to be prevalent in the general population and patients with acute coronary syndrome may at the same time be positive for COVID-19. The aim of this document is to propose algorithms for the management of cardiovascular diseases during COVID-19 emergency with the objective of providing patients with optimal care, minimizing contagion risk and appropriately managing personal protective equipment. keywords: covid-19; disease; emergency; patients; risk cache: cord-032244-s7t5u9lf.txt plain text: cord-032244-s7t5u9lf.txt item: #580 of 2876 id: cord-032335-6c9gt7t9 author: Segrelles-Calvo, Gonzalo title: Therapeutic limitation in elderly patients: Reflections regarding COVID19() date: 2020-09-19 words: 1310 flesch: 37 summary: The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study Association of frailty with short-term outcomes, organ support and resource use in critically ill patients Global prevalence of physical frailty by Fried's criteria in community-dwelling elderly with national population-based surveys Fair allocation of scarce medical resources in the time of Covid-19 Prevalence by age group is 7% in >65-year-olds and 20% in >80year-olds 6 and between 23% and 30% 8, 9 in ICU patients. keywords: frailty; icu; patients cache: cord-032335-6c9gt7t9.txt plain text: cord-032335-6c9gt7t9.txt item: #581 of 2876 id: cord-032392-ex3s8evv author: Matthews, Tamyra title: Single cases from multiple perspectives: a qualitative study comparing the experiences of patients, patients’ caregivers, surgeons, and nurses when bad news is delivered about cancer date: 2020-09-18 words: 6764 flesch: 52 summary: Qualitative literature on the experiences of those delivering and receiving bad news about cancer has revealed what these parties consider important during the process across many different patient cases. [21] The inclusion of the perspective of adult patient caregivers in the current sample attends to the under-representation of this group in the existing qualitative literature. keywords: caregivers; cases; hcps; information; needs; news; patient; study cache: cord-032392-ex3s8evv.txt plain text: cord-032392-ex3s8evv.txt item: #582 of 2876 id: cord-032544-2yrqjw1o author: Haroon, Sabrina-Wong-Peixin title: Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial date: 2020-09-04 words: 5245 flesch: 34 summary: A link between end-stage renal disease and cardiovascular disease? Impact of high coronary artery calcification score (CACS) on survival in patients on chronic hemodialysis Vascular calcification: the killer of patients with chronic kidney disease Mechanistic insights into vascular calcification in chronic kidney disease Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia Vascular calcification in chronic kidney disease: an update The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysis Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-Rich Protein) Vascular calcification: from pathophysiology to biomarkers Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency Kidney Diseases Improving Global Outcomes has recommended routine screening of vascular calcification for dialysis patients, but the subsequent plan of management remains unclear and controversial. keywords: aortic; cac; calcification; hemodialysis; patients; population; study; treatment; trial; vascular; vitamin cache: cord-032544-2yrqjw1o.txt plain text: cord-032544-2yrqjw1o.txt item: #583 of 2876 id: cord-032588-8bfl2qy1 author: None title: 51. Jahrestagung der Österreichischen Gesellschaft für Innere Medizin date: 2020-09-18 words: 7889 flesch: 46 summary: Obwohl sich der Allgemeinzustand der Patientin nach wenigen Tagen bessert, hat sie im weiteren Verlauf trotz täglicher Bikarbonat-Infusionen und adäquater Kontrolle der Diarrhö eine chronische therapierefraktäre metabolische Azidose mit pH 7,0. 59-72), und der Großteil der PatientInnen war in gutem Allgemeinzustand (ECOG 0-1: n = 409, 91 %). keywords: age; als; auf; behandlung; bei; bis; cap; ckd; colonoscopies; das; den; der; des; diabetes; die; eine; für; influenza; ist; median; mit; mortality; patienten; patients; period; rates; results; score; sich; sowie; study; therapie; und; von; war; waren; werden; wurde; years; zur cache: cord-032588-8bfl2qy1.txt plain text: cord-032588-8bfl2qy1.txt item: #584 of 2876 id: cord-032928-m0awip9y author: Sobh, Eman title: Novel coronavirus disease 2019 (COVID-19) non-respiratory involvement date: 2020-10-01 words: 4025 flesch: 38 summary: Zhonghua bing li xue za zhi= Pathological findings in the testes of COVID-19 patients: clinical implications SARS-CoV-2 and the testis: similarity with other viruses and routes of infection The need for urogenital tract monitoring in COVID-19 Orchitis: a complication of severe acute respiratory syndrome (SARS) Cytokines and the immune-testicular axis Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China COVID-19 and anosmia: a review based on up-to-date knowledge Human coronaviruses: respiratory pathogens revisited as infectious neuroinvasive, neurotropic, and neurovirulent agents Middle East respiratory syndrome National Health Commission of the People's Republic of China. Several studies reported acute kidney injury (AKI) in COVID-19 patients with variable incidence rate [24, 26, 32, 34, 35] . keywords: coronavirus; cov-2; covid-19; disease; infection; injury; kidney; manifestations; patients; sars; symptoms cache: cord-032928-m0awip9y.txt plain text: cord-032928-m0awip9y.txt item: #585 of 2876 id: cord-032930-ohsh46l2 author: Liu, Priscila Menezes Ferri title: Hepatorenal syndrome in children: a review date: 2020-10-01 words: 7412 flesch: 38 summary: Nevertheless, the mortality rate is very high among HRS patients and many patients may not survive until transplantation. With proper treatment and early diagnosis, the outcome of LTx in HRS patients can be similar to that of LTx in non-HRS patients [72] . keywords: acute; aki; ascites; children; cirrhosis; function; hrs; kidney; liver; patients; studies; syndrome; treatment; type cache: cord-032930-ohsh46l2.txt plain text: cord-032930-ohsh46l2.txt item: #586 of 2876 id: cord-033019-4eo037jp author: Garnier, Marc title: Answer to the letter by Niño et al date: 2020-10-02 words: 1095 flesch: 38 summary: In this sense, this recommendation follows the recommendations of the French government and scientific societies, which stipulate that the use of FFP2 type masks should only be used for invasive medical procedures or for manoeuvres on the respiratory tract in COVID-19 patients, in any highly suspicious patient or in patients with proven contact with a COVID-19 patient, whether this procedure is carried out by a doctor, a non-physician caregiver, a dentist or a physiotherapist [6, 7] . Finally, it should be noted that teleconsultation is sometimes not possible, particularly with elderly patients, those who are not computerliterate or who are visually or hearing impaired, and that in all studies on the subject a small contingent of patients are excluded from teleconsultation groups; patients in whom in-face consultation will always be necessary. keywords: consultation cache: cord-033019-4eo037jp.txt plain text: cord-033019-4eo037jp.txt item: #587 of 2876 id: cord-033135-cxsmxk3b author: Palomo Cobos, Luis title: Chronicity and primary care in times of pandemic() date: 2020-10-03 words: 1797 flesch: 36 summary: key: cord-033135-cxsmxk3b authors: Palomo Cobos, Luis; Corrales Nevado, Dolores title: Chronicity and primary care in times of pandemic() date: 2020-10-03 journal: nan DOI: 10.1016/j.sedeng.2020.05.002 sha: doc_id: 33135 cord_uid: cxsmxk3b nan being too close together, were being treated, either rightly or wrongly, with psychotropic drugs and these drugs are associated with a higher probability of pneumonia. The protocol of the neurological patient who may currently be suffering the consequences of lockdown in the context of primary care, would be adults and the elderly over 65 years of age with sequelae of strokes or who suffered from Alzheimer's disease or any other type of dementia or Parkinson's disease, with different degrees of severity relating to the course of the disease. keywords: care; face; health; lockdown; patients; risk cache: cord-033135-cxsmxk3b.txt plain text: cord-033135-cxsmxk3b.txt item: #588 of 2876 id: cord-033247-2cbslnb7 author: Alsaied, Tarek title: From Other Journals: A Review of Recent Articles in Pediatric Cardiology date: 2020-10-06 words: 2977 flesch: 37 summary: Secondary repair of incompetent pulmonary valves after previous surgery or intervention: patient selection and outcomes Anomalous aortic origin of a coronary artery from the inappropriate sinus of valsalva Prevalence and cause of early Fontan complications: does the lymphatic circulation play a role? MRI evaluation of lymphatic abnormalities in the neck and thorax after Fontan surgery: relationship with outcome Recommendations for participation in competitive sport in adolescent and adult athletes with Congenital Heart Disease (CHD): position statement of the Sports Cardiology & Exercise Section of the European Association of Preventive Cardiology (EAPC), the European Society of Cardiology (ESC) Working Group on Adult Congenital Heart Disease and the Sports Cardiology, Physical Activity and Prevention Working Group of the Association for European Paediatric and Congenital Cardiology (AEPC) Combination of F-ASO and targeted medical therapy in patients with secundum ASD and severe PAH Longterm clinical outcomes of losartan in patients with Marfan syndrome: follow-up of the multicentre randomized controlled COM-PARE trial Surgical management of progressive pulmonary venous obstruction after repair of total anomalous pulmonary venous connection Mitral valve replacement with the 15-mm mechanical valve: a 20-year multicenter experience Outcomes of mitral valve replacement in children: a competing-risks analysis The authors declare that they have no conflicts of interest. The articles address (1) outcomes after anomalous aortic origin of the coronary artery repair which showed relief of ischemia in most patients with low mortality, (2) the role of lymphatic imaging to predict post-Fontan complications which showed that lymphatic imaging by MRI may have an added prognostic value, (3) European guidelines for participation in competitive sports in congenital heart disease patients using a systematic approach based on ventricular structure and function, pulmonary pressure, aortic root, arrhythmia, and cyanosis, (4) fenestrated atrial septal defect closure combined with medical therapy in patients with severe pulmonary hypertension which resulted in improved pulmonary pressure and offered hope for this population, (5) animal model study for pulmonary vein stenosis postsurgery showing activation of the mammalian target of rapamycin pathway and that application of rapamycin at the anastomosis location may prevent pulmonary vein stenosis, and (6) mitral valve replacement with the 15-mm mechanical valve describing a 20-year multicenter experience from the Netherland that showed that this “dime valve” may be a good option for small infants with mitral valve disease. keywords: aortic; median; patients; pulmonary; rapamycin; valve cache: cord-033247-2cbslnb7.txt plain text: cord-033247-2cbslnb7.txt item: #589 of 2876 id: cord-033279-bcf9568a author: Vujaklija Brajković, Ana title: Utility of procalcitonin in a medical intensive care unit in Croatia date: 2020-10-06 words: 4014 flesch: 34 summary: A randomized controlled trial Effect of sodium selenite administration and procalcitonin-guided therapy on mortality in patients with severe sepsis or septic shock: a randomized clinical trial Procalcitonin levels to guide antibiotic therapy in adults with non-microbiologically proven apparent severe sepsis: a randomised controlled trial Procalcitonin-guided antibiotic therapy in intensive care unit patients: a systematic review and meta-analysis Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials Procalcitonin(PCT)-guidedantibioticstewardship: an international experts consensus on optimized clinical use Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (how long study): an open-label, randomised, controlled phase 4 trial The third international consensus definitions for sepsis and septic shock (sepsis-3) clinical practice guideline for acute kidney injury APACHE II: a severity of disease classification system Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Vital signs: improving antibiotic use among hospitalized patients Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial Stop antibiotics on guidance of procalcitonin study (SAPS): a randomised prospective multicenter investigator-initiated trial to analyse whether daily measurements of procalcitonin versus a standard-of-care approachcansafelyshortenantibioticdurationinintensive care unit patients-calculated sample size: 1816 patients Procalcitonin (PCT)-guidedalgorithm reduces length of antibiotic treatment in surgical intensive carepatients withseveresepsis: results of aprospectiverandomized study Procalcitonin-guided algorithm to reduce length of antibiotic therapy in patients with severe sepsis and septic shock Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study Procalcitonin usefulness for the initiation of antibiotic treatment in intensive care unit patients Procalcitonin versus C-reactive protein for guiding antibiotic therapy in sepsis: a randomized trial Clinical and economic impact of procalcitonin to shorten antimicrobial therapy in septic patients with proven bacterial infection in an intensive care setting Procalcitonin algorithm in critically ill adults with undifferentiated infection or suspected sepsis. keywords: care; infection; patients; pct; procalcitonin; sepsis; study; therapy cache: cord-033279-bcf9568a.txt plain text: cord-033279-bcf9568a.txt item: #590 of 2876 id: cord-033327-yi1tvsh4 author: None title: AANP Forum date: 2020-10-08 words: 1736 flesch: 45 summary: Patients are often unaware of these benefits, and NPs are in prime position to identify when patients are candidates for DME. Great patient care happens when NPs have the tools they need and a supportive policy practice environment to best serve their community. keywords: care; depression; dme; health; nps; patient cache: cord-033327-yi1tvsh4.txt plain text: cord-033327-yi1tvsh4.txt item: #591 of 2876 id: cord-033574-4y53ryoa author: Tashiro, Hiroki title: Biomarkers for Overweight in Adult-Onset Asthma date: 2020-10-02 words: 2697 flesch: 42 summary: Overweight asthma patients had a higher annual exacerbation rate, lower pulmonary function even when treated frequently with high-dose inhaled corticosteroids, and a significantly lower percentage of eosinophils and lower eosinophil count compared to non-overweight asthma patients (p<0.01, p=0.03). RANTES/CCL5, which is upregulated in adipose tissue of obese individuals 16 and associated with obesity-induced pathophysiology, such as atherosclerosis and sleep apnea syndrome, 17, 18 was significantly higher in overweight asthma patients than in non-overweight asthma patients. keywords: adult; asthma; blood; onset; overweight; patients; study cache: cord-033574-4y53ryoa.txt plain text: cord-033574-4y53ryoa.txt item: #592 of 2876 id: cord-033778-u2r0neyc author: Taban, EM title: Observational study of therapeutic bronchoscopy in critical hypoxaemic ventilated patients with COVID-19 at Mediclinic Midstream Private Hospital in Pretoria, South Africa date: 2020-10-13 words: 2579 flesch: 42 summary: For patient 3, the procedure time was 2.5 hours with the lowest oxygen saturation recorded at 40% for 40 seconds and the procedure time for patient 11 was 55 minutes with the lowest oxygen saturation recorded at 36% for 24 seconds Patients 3, 5, 7 and 11 were extubated 72 hours after FFB to high -low nasal cannula and patients 1, 4, 6 and 9 are currently on minimal ventilator settings. [13] In our opinion, therapeutic FFB should be considered as an adjunctive therapy for COVID-19 patients with refractory hypoxaemia or even as a routine therapy around day 7 of mechanical ventilation if patients are slow to improve. keywords: bronchoscopy; covid-19; ffb; mucus; patients; type; ventilation cache: cord-033778-u2r0neyc.txt plain text: cord-033778-u2r0neyc.txt item: #593 of 2876 id: cord-033965-c1i7dnnt author: Christian, Ashton B. title: Comparison of surgical fixation and non-operative management in patients with traumatic sternum fracture date: 2020-10-19 words: 2332 flesch: 45 summary: Treatment of traumatic sternal fractures with titanium plate internal fixation: a retrospective study Do low profile implants provide reliable stability in fixing the sternal fractures as a fourth vertebral column in sternovertebral injuries? Fixation of sternal fractures: a systematic review Sternal fractures: retrospective analysis of 100 cases Current treatment and outcomes of traumatic sternal fractures: a systematic review Operative fixation of chest wall fractures: an underused procedure? Management of sternal fractures: 239 cases Sternum fractures and effects of associated injuries Early surgical repair of isolated traumatic sternal fractures using a cervical plate system Depressed fracture of the sternum Displaced mid-shaft clavicular fractures: is conservative treatment still preferred? However, SSSF patients had a longer median hospital LOS (16 vs. 7 days, p < 0.001), ICU LOS (9.5 vs. 5.5 days, p = 0.016) and ventilator days (8 vs. 5, p = 0.035). keywords: days; fracture; patients; sssf; sternal; sternum cache: cord-033965-c1i7dnnt.txt plain text: cord-033965-c1i7dnnt.txt item: #594 of 2876 id: cord-034036-1wigu3i3 author: Yu, Changhao title: Current epidemiological and etiological characteristics and treatment of seizures or epilepsy in patients with HIV infection date: 2020-10-21 words: 5859 flesch: 44 summary: Opportunistic infections are a stereotypical predisposing factor for seizures in HIV patients, but a variety of pathogenic factors can also be found in these patients, such as metabolic perturbation and drug-drug interactions. As HIV patients with seizures need to take both antivirals and antiepileptic drugs, the risk of drug-drug interactions is greatly increased, and the side effects of drugs may also become more prominent. keywords: children; drug; epilepsy; hiv; incidence; infection; patients; population; seizures; studies; study cache: cord-034036-1wigu3i3.txt plain text: cord-034036-1wigu3i3.txt item: #595 of 2876 id: cord-034157-uif9xtvl author: Ortoleva, Jamel title: Anesthetic Considerations for Recovered COVID-19 Patients date: 2020-10-22 words: 1245 flesch: 23 summary: Clinical Characteristics of Coronavirus Disease 2019 in China Covid-19 in Critically Ill Patients in the Seattle Region -Case Series Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery Pulmonary function in patients surviving to COVID-19 pneumonia Ventilatory support and mechanical properties of the fibrotic lung acting as a squishy ball Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System Thrombosis and coagulopathy in COVID-19 patients requiring extracorporeal membrane oxygenation Prevalence and Impact of Myocardial Injury in Patients Hospitalized With COVID-19 Infection Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection Incidence of Stress Cardiomyopathy During the Coronavirus Disease 2019 Pandemic Dexamethasone in Hospitalized Patients with Covid-19 -Preliminary Report Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19: 17 Neurologic manifestations related to COVID-19 including stroke, intracranial hemorrhage, and critical illness myopathy related to prolonged intubation and immobility are important considerations in recovered COVID-19 patients. keywords: covid-19; patients; surgery cache: cord-034157-uif9xtvl.txt plain text: cord-034157-uif9xtvl.txt item: #596 of 2876 id: cord-034185-e0am7pa6 author: Piccioni, Federico title: Recommendations from the Italian intersociety consensus on Perioperative Anesthesa Care in Thoracic surgery (PACTS) part 2: intraoperative and postoperative care date: 2020-10-23 words: 18225 flesch: 22 summary: Similarly, a meta-analysis of 32 trials involving approximately 2800 patients found a significant reduction in postoperative mortality with goal-directed therapy, compared with controls, in patients at highest risk of postoperative complications (OR 0.20, 95% CI 0.09-0.41, P < 0.0001); there was also a significant reduction in complication rates (OR 0.45, 95% CI 0.34-0.60, P < 0.00001), which was particularly marked in the highest risk subgroup (OR 0.27, 95% CI 0.15-0.51, P < 0.0001) (Cecconi et al. 2013) . Pinheiro et al. 2015) , more extensive resection (Cywinski et al. 2009 ), and impaired preoperative lung function or pulmonary comorbidities such as chronic obstructive pulmonary disease (COPD) (Brunelli et al. 2008; Cywinski et al. 2009; keywords: analgesia; analysis; anesthesia; chest; complications; et al; evidence; level; lung; management; meta; pain; patients; postoperative; pulmonary; randomized; recommendation; resection; risk; strength; studies; study; surgery; thoracic; thoracic surgery; trial; tube; use; ventilation cache: cord-034185-e0am7pa6.txt plain text: cord-034185-e0am7pa6.txt item: #597 of 2876 id: cord-034257-kl2ccmz5 author: de Jonge, Jeroen C. title: PRECIOUS: PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke—statistical analysis plan of a randomised, open, phase III, clinical trial with blinded outcome assessment date: 2020-10-26 words: 3734 flesch: 47 summary: Rationale and design of a randomised, open, phase III, clinical trial with blinded outcome assessment Contemporary outcome measures in acute stroke research Improving the efficiency of stroke trials Statistical analysis of the primary outcome in acute stroke trials Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations None. Medical complications after stroke Characteristic adverse events and their incidence among patients participating in acute ischemic stroke trials Development and internal validation of a prediction rule for post-stroke infection and poststroke pneumonia in acute stroke patients Post-stroke infection: a systematic review and meta-analysis Therapeutic hypothermia in acute ischemic stroke Impact of fever on outcome in patients with stroke and neurologic injury: a comprehensive meta-analysis Effect of hyperthermia on prognosis after acute ischemic stroke Dysphagia after stroke: incidence, diagnosis, and pulmonary complications Temporal profile of body temperature in acute ischemic stroke: relation to infarct size and outcome Poststroke dysphagia: a review and design considerations for future trials Route of feeding as a proxy for dysphagia after stroke and the effect of transdermal glyceryl trinitrate: data from the efficacy of nitric oxide in stroke randomised controlled trial An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study Antibiotic therapy for preventing infections in patients with acute stroke The Paracetamol (Acetaminophen) keywords: analysis; data; days; mrs; outcome; patients; stroke; treatment; trial cache: cord-034257-kl2ccmz5.txt plain text: cord-034257-kl2ccmz5.txt item: #598 of 2876 id: cord-034286-m1c98nv7 author: Wijdicks, Eelco F. M. title: Communicating Neurocritical Illness: The Anatomy of Misunderstanding date: 2020-10-27 words: 3540 flesch: 51 summary: None. Using texting for clinical communication in surgery: a survey of academic staff surgeons Secure clinical texting: patient risk in high-acuity care Email for clinical communication between healthcare professionals Leading article: use of smartphones to pass on information about patients-what are the current issues? We can consider using simulation centers, which might be ideal set-ups for communication scenarios; these could include scenarios with deliberately confusing or vague language to recreate the potential downstream consequences for management. keywords: care; communication; hospital; icu; information; need; patient; time cache: cord-034286-m1c98nv7.txt plain text: cord-034286-m1c98nv7.txt item: #599 of 2876 id: cord-034303-kcu9guxa author: Laimoud, Mohamed title: The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date: 2020-10-27 words: 3196 flesch: 39 summary: key: cord-034303-kcu9guxa authors: Laimoud, Mohamed; Alanazi, Mosleh title: The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date: 2020-10-27 journal: Egypt Heart J DOI: 10.1186/s43044-020-00108-7 sha: doc_id: 34303 cord_uid: kcu9guxa BACKGROUND: Veno-arterial ECMO is a life-supporting procedure that can be done to the patients with cardiogenic shock which is associated with hyperlactatemia. Blood lactate levels were measured by arterial blood gas analysis which had been done hourly in the first few hours after ECMO initiation till haemodynamics stabilization then every 2 h till clearance. keywords: ecmo; lactate; mortality; patients; support; survivors cache: cord-034303-kcu9guxa.txt plain text: cord-034303-kcu9guxa.txt item: #600 of 2876 id: cord-034340-3ksfpaf7 author: None title: Proceedings of the 26th European Paediatric Rheumatology Congress: part 2: Virtual. 23 - 26 September 2020 date: 2020-10-28 words: 35133 flesch: 46 summary: Results: Of the 35 metabolites measured, 23 were significantly lower in JIA patients before the Etanercept treatment compared to the healthy control group. Urine metabolite ratios reflecting CYP21 and 11β-HSD2 enzymatic activity indicate that these two enzyme activities were lower in JIA patients. keywords: activity; adalimumab; age; anti; antibodies; arthritis; cases; children; cohort; conclusion; criteria; data; diagnosis; disease; fever; group; high; inflammation; introduction; involvement; jia; jia patients; joint; juvenile; laboratory; levels; methods; months; mtx; negative; objectives; onset; pain; patients; pediatric; positive; present; pts; report; response; results; rheumatology; sjia; study; symptoms; syndrome; systemic; therapy; treatment; uveitis; years cache: cord-034340-3ksfpaf7.txt plain text: cord-034340-3ksfpaf7.txt item: #601 of 2876 id: cord-034371-j3xxmkjd author: Schellack, Natalie title: COVID-19: Guidelines for pharmacists in South Africa date: 2020-06-10 words: 5044 flesch: 49 summary: • Safe social (and professional) distancing of at least 1 metre between queueing patients (the use of floor markings is recommended) and between pharmacy personnel and patients across the counter • Appropriate respiratory hygiene (which includes the appropriate use of personal protective equipment (PPE) amongst staff and patients Therapeutic agents of concern Current information and guidance Non-steroidal anti-inflammatory drugs (NSAIDs) 4, 14, 23, 24, 25 • The use of ibuprofen (or other NSAIDs) in COVID-19 patients has been raised as a potential concern. In addition, COVID-19 patients have an increased risk of developing deep vein thrombosis (DVT) and pulmonary embolism (PE). keywords: contact; coronavirus; covid-19; disease; evidence; infection; patients; risk; treatment; use; virus cache: cord-034371-j3xxmkjd.txt plain text: cord-034371-j3xxmkjd.txt item: #602 of 2876 id: cord-034435-yp0gfl47 author: Medetalibeyoglu, A. title: Older Adults Hospitalized with Covid-19: Clinical Characteristics and Early Outcomes from a Single Center in Istanbul, Turkey date: 2020-10-08 words: 4768 flesch: 43 summary: In conclusion, this study shows that older Covid-19 patients that were hospitalized presented with more prevalent chronic comorbidities, less prevalent symptomatology (i.e., cough and fever) but more severe respiratory signs and laboratory abnormalities than the younger patients. In the radiological evaluation, more than half of the patients (54.6%) had moderate-severe pneumonia, which was more prevalent in older patients (66% vs. 50%) (p=0.006). keywords: adults; covid-19; disease; laboratory; mortality; patients; pneumonia; study cache: cord-034435-yp0gfl47.txt plain text: cord-034435-yp0gfl47.txt item: #603 of 2876 id: cord-034578-i9rdubix author: Vaschetto, Rosanna title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 words: 3688 flesch: 42 summary: The rate of mortality observed in our study, is not divergent from those reported in several prior studies [9, 10, 15, 12, 13] for ICU patients, predominantly intubated, which varied from 17% [13] to 67% key: cord-034578-i9rdubix authors: Vaschetto, Rosanna; Barone-Adesi, Francesco; Racca, Fabrizio; Pissaia, Claudio; Maestrone, Carlo; Colombo, Davide; Olivieri, Carlo; De Vita, Nello; Santangelo, Erminio; Scotti, Lorenza; Castello, Luigi; Cena, Tiziana; Taverna, Martina; Grillenzoni, Luca; Moschella, Maria Adele; Airoldi, Gianluca; Borrè, Silvio; Mojoli, Francesco; Della Corte, Francesco; Navalesi, Paolo; Cammarota, Gianmaria; Baggiani, Marta; Baino, Sara; Balbo, Piero; Bazzano, Simona; Bonato, Valeria; Carbonati, Sara; Crimaldi, Federico; Daffara, Veronica; De Col, Luca; Maestrone, Matteo; Malerba, Mario; Moroni, Federica; Perucca, Raffaella; Pirisi, Mario; Rondi, Valentina; Rosalba, Daniela; Vanni, Letizia; Vigone, Francesca title: Outcomes of COVID-19 patients treated with continuous positive airway pressure outside ICU date: 2020-10-30 journal: keywords: cpap; hospital; icu; intubation; mortality; patients; study; treatment cache: cord-034578-i9rdubix.txt plain text: cord-034578-i9rdubix.txt item: #604 of 2876 id: cord-034690-x8lkngra author: Ridge, Carole A title: Dual-Energy CT Pulmonary Angiography (DECTPA) Quantifies Vasculopathy in Severe COVID-19 Pneumonia date: 2020-10-29 words: 3220 flesch: 35 summary: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management Pulmonary High-Resolution Computed Tomography (HRCT) Findings of Patients with Early-Stage Coronavirus Disease 2019 (COVID-19) in Hangzhou, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Chest CT Findings in Coronavirus Disease-19 (COVID-19): Relationship to Duration of Infection Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China COVID-19 pneumonia: different respiratory treatments for different phenotypes? Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Clinical and immunological features of severe and moderate coronavirus disease 2019 Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Acute pulmonary embolism and COVID-19 pneumonia: a random association? COVID-19 Complicated by Acute Pulmonary Embolism Ventilatory Ratio in Hypercapnic Mechanically Ventilated Patients with COVID-19-associated Acute Respiratory Distress Syndrome Hypoxaemia related to COVID-19: vascular and perfusion abnormalities on dual-energy CT Pulmonary angiopathy in severe Covid-19: physiologic, imaging and hematologic observations Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans Pulmonary infarction secondary to pulmonary thromboembolism in COVID-19 diagnosed with dual-energy CT pulmonary angiography Radiology: Pulmonary Vascular Manifestations of COVID-19 Pneumonia Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands Pulmonary Embolism on CTPA in COVID-19 Patients Clinical Significance of Late Phase of Lung Perfusion Blood Volume (Lung Perfusion Blood Volume) Quantified by Dual-Energy Computed Tomography in Patients With Pulmonary Thromboembolism New CT index to quantify arterial obstruction in pulmonary embolism: comparison with angiographic index and echocardiography Correlation analysis of dual-energy CT iodine maps with quantitative pulmonary perfusion MRI Segmental Anatomy of the Lungs Dualenergy CT angiography for assessment of regional pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: initial experience Dual-energy CT for imaging of pulmonary hypertension: challenges and opportunities Dual-energy CT for the assessment of contrast material distribution in the pulmonary parenchyma Pulmonary vasospasm in systemic sclerosis: noninvasive techniques for detection The Spectrum of Cardiac Manifestations in Coronavirus Disease 2019 (COVID-19) -a As future randomized controlled trials are devised, we suggest that DECTPA is used as a surveillance tool, to determine whether the temporal pattern of pulmonary perfusion represents the natural history of the disease, or an anticoagulation-related effect. keywords: covid-19; disease; paenh; patients; pbv; perfusion; pneumonia; pulmonary cache: cord-034690-x8lkngra.txt plain text: cord-034690-x8lkngra.txt item: #605 of 2876 id: cord-034746-uxhpufnv author: Nusshag, Christian title: Glomerular filtration barrier dysfunction in a self-limiting, RNA virus-induced glomerulopathy resembles findings in idiopathic nephrotic syndromes date: 2020-11-05 words: 3655 flesch: 29 summary: Interestingly, the start of normalization of urinary nephrin and PCR levels preceded the first decline of SCr by 48-72 h. Furthermore, in patients with an available urine sample at the time of PCR normalization, the normalization of urinary nephrin levels tended to precede the normalization of PCR levels. In contrast to INS, proteinuria recovered autonomously in hantavirus patients. keywords: hantavirus; igg; infection; levels; nephrin; patients; pcr; proteinuria; urinary cache: cord-034746-uxhpufnv.txt plain text: cord-034746-uxhpufnv.txt item: #606 of 2876 id: cord-034898-zjfhpum2 author: Patangi, Sanjay Orathi title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date: 2020-11-07 words: 7533 flesch: 37 summary: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition A comparison of pumpcontrolled retrograde trial off to arterio-venous bridging for weaning from venoarterial extracorporeal membrane oxygenation Extracorporeal membrane oxygenation for infant postcardiotomy support: significance of shunt management Fontan physiology revisited Clinical outcomes in patients after extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock: a single-centre experience of 92 cases Outcomes of venoarterial extracorporeal membrane oxygenation patients requiring multiple episodes of support Longterm survival in adults treated with extracorporeal membrane oxygenation for respiratory failure and sepsis Long-term prognosis after extracorporeal life support in refractory cardiogenic shock -results from a real-world cohort Patients' self-assessed functional status in heart failure by New York Heart Association class: a prognostic predictor of hospitalizations, quality of life and death Long-term outcomes of extracorporeal membrane oxygenation support for postcardiotomy shock Financial and clinical outcomes of extracorporeal mechanical support The comparative use of ventricular assist devices: differences between Europe and the United States Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Acknowledgements Weaning of extracorporeal membrane oxygenation using continuous hemodynamic transesophageal echocardiography Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock Venoarterial extracorporeal membrane oxygenation in cardiogenic shock Pump controlled retrograde trial off from VA-ECMO Levosimendan may improve weaning outcomes in venoarterial ECMO patients Pharmacologic approaches to weaning from cardiopulmonary bypass and extracorporeal membrane oxygenation Functional evaluation of sublingual microcirculation indicates successful weaning from VA-ECMO in cardiogenic shock Clinical pearls of venoarterial extracorporeal membrane oxygenation for cardiogenic shock Extracorporeal membrane oxygenation, an anesthesiologist's perspective: physiology and principles. keywords: arterial; cardiac; circuit; ecmo; extracorporeal; flow; incidence; membrane; membrane oxygenation; mortality; outcomes; oxygenation; patients; post; shock; support; weaning cache: cord-034898-zjfhpum2.txt plain text: cord-034898-zjfhpum2.txt item: #607 of 2876 id: cord-035024-kx9jfssi author: Elmelhat, Ahmed title: Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome date: 2020-10-26 words: 3194 flesch: 47 summary: [7] suggested that in the absence of venous thromboembolic prophylaxis, 25% of COVID-19 patients developed lower extremity deep venous thrombosis, which is higher than the 5-15% incidence seen in placebo arms of early studies of VTE prevention in medically ill hospitalized patients [8] [9] [10] . To the best of our knowledge, this is the first study published to compare the 2 dose regimens in the management of COVID-19 patients. keywords: cases; difference; dose; group; patients; study cache: cord-035024-kx9jfssi.txt plain text: cord-035024-kx9jfssi.txt item: #608 of 2876 id: cord-035026-2qcsfd87 author: Ugwueze, Chidiebere V. title: COVID-19 and Diabetes Mellitus: The Link and Clinical Implications date: 2020-10-23 words: 5416 flesch: 39 summary: Diabetes mellitus is one of commonest noncommunicable diseases associated with worsening clinical status in COVID-19 patients. Pathogenetic mechanisms such as impaired immunity, microangiopathy, and glycemic variability may explain the effect of diabetes on recovery of COVID-19 patients. keywords: ace2; coronavirus; covid-19; diabetes; disease; effect; infection; insulin; patients; receptor; sars; type cache: cord-035026-2qcsfd87.txt plain text: cord-035026-2qcsfd87.txt item: #609 of 2876 id: cord-035030-ig4nwtmi author: None title: 10th European Conference on Rare Diseases & Orphan Products (ECRD 2020) date: 2020-11-09 words: 12246 flesch: 45 summary: While some barriers are being removed through remarkable innovation, there is one story of diagnostic delay that is echoed by rare disease patients across the globe and across thousands of different rare diseases: doctors failed to suspect something rare. The recognition of Clinical Genetics as health specialty is also urgent in Spain to provide equal access to RD patients and families all over the country. keywords: access; care; countries; data; development; diseases; european; families; health; information; life; needs; patients; people; processes; professionals; project; quality; rare; registry; research; results; study; treatment; use; work cache: cord-035030-ig4nwtmi.txt plain text: cord-035030-ig4nwtmi.txt item: #610 of 2876 id: cord-035067-ic843wr9 author: de Almeida, Joana Ferro Machado title: COVID-19 and the gastrointestinal tract: what do we already know? date: 2020-11-05 words: 5454 flesch: 50 summary: SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues ACE-2 expression in the small airway epithelia of smokers and COPD Patients: Implications for COVID-19 COVID-19 and diabetes: Knowledge in progress Association of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use with covid-19 diagnosis and mortality Association of renin-angiotensin system inhibitors with severity or risk of death in patients with hypertension hospitalized for coronavirus disease 2019 (COVID-19) infection in Wuhan, China Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China Enteric involvement in hospitalised patients with COVID-19 outside Wuhan Prevalence and characteristics of gastrointestinal symptoms in patients with SARS-CoV-2 infection in the United States: a multicenter cohort study Gastrointestinal symptoms and COVID-19: case-control study from the United States High prevalence of concurrent gastrointestinal manifestations in patients with SARS-CoV-2: early experience from California Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Effect of gastrointestinal symptoms on patients infected with COVID-19 Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis Gastrointestinal infection could be new focus for coronavirus diagnosis Individual variation of the SARS-CoV2 receptor ACE2 gene expression and regulation Those infected may be asymptomatic, present typical symptoms (fever, dry cough and dyspnea), gastrointestinal symptoms (diarrhea, nausea, vomiting and abdominal pain) and viral RNA in stools. keywords: cov-2; covid-19; disease; patients; sars; studies; study; symptoms; viral; virus cache: cord-035067-ic843wr9.txt plain text: cord-035067-ic843wr9.txt item: #611 of 2876 id: cord-035070-drt6esrk author: Cheng, Yichun title: Risk Factors and Outcomes of Acute Kidney Injury in Critically Ill Patients with Coronavirus Disease 2019 date: 2020-10-26 words: 3664 flesch: 49 summary: In accordance with the recent reports on the outcomes of COVID-19 patients, 5-26% of patients will be admitted to the intensive care unit during hospitalization [4] [5] [6] . However, due to the small number of patients and the bias in a different therapy of COVID-19 patients, the causal relationship between medications and AKI in critically ill COV-ID-19 patients remains undetermined. keywords: aki; covid-19; hospital; kidney; mortality; patients; severe; study cache: cord-035070-drt6esrk.txt plain text: cord-035070-drt6esrk.txt item: #612 of 2876 id: cord-035090-gnfeyddv author: Su, Qi title: Adults with severe Japanese encephalitis: a retrospective analysis of 9 cases in Linyi, China date: 2020-11-09 words: 3883 flesch: 43 summary: The initial manifestations of JE patients presenting to the hospital included high fever (100%), the mean temperature was 39.1°C (SD, 0.82°C); headache ((66.7%); and vomiting (11.1%); status epilepticus was observed in 4 patients (44.4%), with the median occurrence time of 5 days (range, 3.25-6 days) after onset, and all patients (100%) experienced varying degrees of consciousness disorder, with an average occurrence time of 4 days (SD, 2.87 days) after onset, including 3 patient with hypersomnia, 2 cases with light coma, 2 cases with moderate coma, and 2 cases with deep coma. At present, there is no standard to evaluate the outcome of JE patients at home and abroad [24, 25] . keywords: brain; cases; data; days; encephalitis; outcome; patients; study cache: cord-035090-gnfeyddv.txt plain text: cord-035090-gnfeyddv.txt item: #613 of 2876 id: cord-035182-ax6v3ak5 author: Griebenow, Reinhard title: Outcomes in CME/CPD - Special Collection: How to make the “pyramid” a perpetuum mobile date: 2020-10-27 words: 2785 flesch: 26 summary: In targeting community health CME must therefore take responsibility for discussing all the pros and cons involved in improving community health. Community health is the sum of the various forces working for and against community health. keywords: care; cme; community; competence; covid-19; disease; e.g.; health; medical; patient cache: cord-035182-ax6v3ak5.txt plain text: cord-035182-ax6v3ak5.txt item: #614 of 2876 id: cord-035315-j5mknuv5 author: Rahim, Fawad title: Mortality of Patients With Severe COVID-19 in the Intensive Care Unit: An Observational Study From a Major COVID-19 Receiving Hospital date: 2020-10-12 words: 2715 flesch: 54 summary: This necessitated determining the survival of COVID-19 patients in relation to comorbid conditions and ventilatory support in our population. The high mortality with IMV patients could be due to inadequate intensive care services and lack of enough experience with treating COVID-19 related acute respiratory distress syndrome. keywords: age; covid-19; icu; mortality; patients; study cache: cord-035315-j5mknuv5.txt plain text: cord-035315-j5mknuv5.txt item: #615 of 2876 id: cord-035316-l4qbiuuu author: Dacie, Ruth title: Spontaneous Aortic Haematoma in a Patient Receiving Adjuvant Folinic Acid, 5-Fluorouracil, Irinotecan, and Oxaliplatin Chemotherapy Following Resection of a Pancreatic Adenocarcinoma date: 2020-10-12 words: 2273 flesch: 39 summary: A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer Aortic intramural hematoma and its complications Vasculitides associated with malignancies: analysis of sixty patients A case of aortitis during cisplatin-based chemotherapy for cervical cancer Oxaliplatin-induced leukocytoclastic vasculitis under adjuvant chemotherapy for colorectal cancer: two cases of a rare adverse event Small-vessel vasculitis following treatment with combination 5 Case 4: fluorouracil-related small bowel vasculitis. Adjuvant chemotherapy following resection has been shown to improve outcomes, although recurrence is common and prognosis remains poor keywords: aortic; aortitis; chemotherapy; haematoma; patient; vasculitis cache: cord-035316-l4qbiuuu.txt plain text: cord-035316-l4qbiuuu.txt item: #616 of 2876 id: cord-035396-lg7m9xzs author: Bains, Amarpreet S. title: Maintaining Throughput and Reducing Discharge Delays After Increasing Capacity During The Covid-19 Pandemic: A New York City Hospital’s Experience date: 2020-11-12 words: 2408 flesch: 43 summary: The average length of stay for Covid-19 patients who did require home oxygen was only 0.5 days longer than for those who did not: more than a 50% reduction in turnaround compared with our pre-pandemic timeframe for home oxygen setup. We attribute this improvement to: better communication between unit managers and discharge control center; earlier identification of barriers; on-site representative for home oxygen; streamlining of the documentation and authorization processes; providers learning how to optimize documentation; and time saved by many patients not requiring home delivery. keywords: covid-19; discharge; home; oxygen; pandemic; patients cache: cord-035396-lg7m9xzs.txt plain text: cord-035396-lg7m9xzs.txt item: #617 of 2876 id: cord-048343-nzk8m912 author: Milbrandt, Eric B title: Bench-to-bedside review: Critical illness-associated cognitive dysfunction – mechanisms, markers, and emerging therapeutics date: 2006-11-15 words: 5793 flesch: 28 summary: An experimental study in dogs Cerebral hemodynamics, vascular reactivity, and metabolism during canine endotoxin shock Group B streptococcal sepsis impairs cerebral vascular reactivity to acute hypercarbia in piglets Neuropathology of septic shock Multifocal necrotizing leukoencephalopathy in septic shock Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock The neuropathology of septic shock The role of hypotension in septic encephalopathy following surgical procedures Cerebral circulation and metabolism in patients with septic encephalopathy Different C-reactive protein kinetics in post-operative hip-fractured geriatric patients with and without complications The role of oxidative stress in postoperative delirium Regional cerebral blood flow in delirium patients Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome Hyperglycemia and neurocognitive outcome in ARDS survivors Hyperglycemia augments ischemic brain injury: in vivo MR imaging/spectroscopic study with nicardipine in cats with occluded middle cerebral arteries Signs of brain cell injury during open heart operations: past and present Release of glial tissue-specific proteins after acute stroke: a comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein Is there an association between release of protein S100B during cardiopulmonary bypass and memory disturbances? Although there are no studies evaluating the effectiveness of cognitive rehabilitation in patients recovering from non-neurologic critical illness, it stands to reason that such patients could benefit when they are found to be cognitively impaired. keywords: acute; anticholinergic; brain; delirium; icu; illness; injury; levels; mechanisms; patients; serum; studies; study cache: cord-048343-nzk8m912.txt plain text: cord-048343-nzk8m912.txt item: #618 of 2876 id: cord-048489-ajafw966 author: Bozza, Fernando A title: Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity date: 2008-06-25 words: 4939 flesch: 41 summary: R Foundation for Statistical Computing Activation of T lymphocytes in dengue virus infections. Chemotaxis, Ca2+ mobilization, and enzyme release Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis Elevated tumour necrosis factor in dengue fever and dengue haemorrhagic fever Plasma levels of tumour necrosis factor alpha and transforming growth factor beta-1 in children with dengue 2 virus infection in French Polynesia Correlation Of Serum Levels Of Macrophage Migration Inhibitory Factor With Disease Severity And Clinical Outcome In Dengue Patients Characterisation of lymphocyte response and cytokine patterns in patients with dengue fever Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections Th(2) immune response in patients with dengue during defervescence: preliminary evidence Altered cytokine responses of dengue-specific CD4+ T cells to heterologous serotypes Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren Alternative activation of macrophages Effects of granulocyte-monocyte colony-stimulating factor (GM-CSF) on expression of adhesion molecules and production of cytokines in blood monocytes and ovarian cancer-associated macrophages MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells IL8 release, tight junction and cytoskeleton dynamic reorganization conducive to permeability increase are induced by dengue virus infection of microvascular endothelial monolayers Predictors of spontaneous bleeding in Dengue Dengue and dengue hemorrhagic fever, Brazil Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever-dengue shock syndrome (DHF/DSS) keywords: cells; cytokine; dengue; disease; fever; ifn; levels; mip-1β; patients; plasma; severity; virus cache: cord-048489-ajafw966.txt plain text: cord-048489-ajafw966.txt item: #619 of 2876 id: cord-102199-mc6zruyx author: Toksvang, Linea Natalie title: Hepatotoxicity during 6-thioguanine treatment in inflammatory bowel disease and childhood acute lymphoblastic leukaemia: a systematic review date: 2019-01-30 words: 2384 flesch: 15 summary: Pediatr Blood Cancer 6-Thioguanine: A new old drug to procure remission in inflammatory bowel disease High variation of tioguanine absorption in patients with chronic active Crohn's disease 6-thioguanine can cause serious liver injury in inflammatory bowel disease patients 6-Thioguanine associated nodular regenerative hyperplasia in patients with inflammatory bowel disease may induce portal hypertension Treatment of inflammatory bowel disease with 6-thioguanine (6-TG): Retrospective case series from a tertiary care center Efficacy of 6-thioguanine in patients with Crohn's disease intolerant to azathioprine Biotransformation of 6-thioguanine in inflammatory bowel disease patients: A comparison of oral and intravenous administration of 6-thioguanine Lower 6-thioguanine (6-TG) levels may be as effective as higher 6-TG levels in IBD patients treated with thioguanine 6-Thioguanine in children with acute lymphoblastic leukaemia: Influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations 6-Thioguanine as an alternative therapy in inflammatory bowel disease-experience in a London district general hospital Splitting a therapeutic dose of thioguanine may avoid liver toxicity and be an efficacious treatment for severe inflammatory bowel disease: a 2-center observational cohort study Efficacy and safety of 6-thioguanine in the management of inflammatory bowel disease To evaluate the efficacy and safety of 6-thioguanine therapy in patients with inflammatory bowel disease-a London DGH experience A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease Toxicity and efficacy of intensive chemotherapy for children with acute lymphoblastic leukemia (ALL) after first bone marrow or extramedullary relapse The Prevalence of Nodular Regenerative Hyperplasia in Inflammatory Bowel Disease Patients Treated with Thioguanine Is Not Associated with Clinically Significant Liver Disease Thioguanine in inflammatory bowel disease: Long-term efficacy and safety. Pediatr Blood Cancer Psychosomatic complications during treatment for ulcerative colitis Long-term follow-up of children with 6-thioguanine-related chronic hepatoxicity following treatment for acute lymphoblastic leukaemia Variceal hemorrhage in a patient with ulcerative colitis treated with 6-thioguanine Acute sinusoidal obstruction syndrome after 6-thioguanine therapy for Crohn's disease Thioguanine treatment-related sinusoidal obstruction syndrome in 2 children MRI Patterns in a Case of 6-Thioguanine-Related Hepatic Sinusoidal Obstruction Syndrome Safe 6-thioguanine therapy of a TPMT deficient Crohn's disease patient by using therapeutic drug monitoring Veno-occlusive disease of the liver associated with thiopurines in a child with acute lymphoblastic leukemia Pharmacokinetics of 6-thioguanine and 6-mercaptopurine combination maintenance therapy of childhood ALL: Hypothesis and case report The case of colitis ulcerosa -Diagnostic and therapeutic difficulties Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease Liver venoocclusive disease (VOD) in a patient given 6-thioguanine for crohn's disease Early nodular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapy Safety of Tioguanine During Pregnancy in Inflammatory Bowel Disease Thioguanine-induced symptomatic thrombocytopenia On the limitation of 6-tioguaninenucleotide monitoring during tioguanine treatment Thioguanine use in inflammatory bowel disease: 13 year experience in a tertiary centre Toxicity of 6-thioguanine: no hepatotoxicity in a series of IBD patients treated with longterm, low dose 6-thioguanine. keywords: 6tg; acute; bowel; disease; hepatotoxicity; patients; thioguanine cache: cord-102199-mc6zruyx.txt plain text: cord-102199-mc6zruyx.txt item: #620 of 2876 id: cord-102276-0a8hup5y author: Savage, R. S. title: Development and validation of multivariable machine learning algorithms to predict risk of cancer in symptomatic patients referred urgently from primary care date: 2020-10-27 words: 3795 flesch: 48 summary: Whilst there is variation between cancer pathways, only 7% overall of 2WW referral patients are diagnosed with cancer. In use-case 2, they identify 90% of cancer cases with a high probability of cancer that could be prioritised for review. keywords: 2ww; cancer; medrxiv; patients; preprint; risk; use cache: cord-102276-0a8hup5y.txt plain text: cord-102276-0a8hup5y.txt item: #621 of 2876 id: cord-103214-3lz33pj3 author: Kortuem, S. O. title: The Role of the Emergency Department in Protecting the Hospital as a Critical Infrastructure in the Corona Pandemic Strategies and Experiences of a Rural Sole Acute-Care Clinic date: 2020-09-09 words: 4295 flesch: 40 summary: All confirmed COVID-19 cases were correctly identified in the structured pretriage, unprotected contacts with employees or other patients did not take place, nosocomial transmissions were not known. An essential strategic element was a very short-term restructuring of the Emergency Department with the objectives of reducing the number of cases within the clinic, detecting COVID-19 cases as sensitively as possible and separating the patient pathways at an early stage. keywords: cases; clinical; covid-19; department; emergency; hospital; patients; preprint; time cache: cord-103214-3lz33pj3.txt plain text: cord-103214-3lz33pj3.txt item: #622 of 2876 id: cord-103659-wpwfqhp2 author: Almqvist, J. title: Neurological manifestations of coronavirus infections: a systematic review date: 2020-09-01 words: 6079 flesch: 36 summary: The lancet Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study Dysregulation of immune response in patients with COVID-19 in Wuhan, China European Patients with mild-to-moderate Coronavirus Disease Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Olfactory Bulb Magnetic Resonance Imaging in SARS-CoV-2-Induced Anosmia: The First Report Early recovery following new onset anosmia during the COVID-19 pandemic-an observational cohort study Acute-onset smell and taste disorders in the context of Covid-19: a pilot multicenter PCR-based case-control study Patterns of smell recovery in 751 patients affected by the COVID-19 outbreak Persistent Symptoms in Patients After Acute COVID-19 The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings COVID-19 related neuroimaging findings: A signal of thromboembolic complications and a strong prognostic marker of poor patient outcome Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description Imaging in Neurological Disease of Hospitalized COVID-19 Patients: An Italian Multicenter Retrospective Observational Study Risk of Ischemic Stroke in Patients With Coronavirus Disease 2019 (COVID-19) vs Patients With Influenza Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. keywords: copyright; cov-2; funder; holder; license; medrxiv; patients; peer; preprint; review; sars; september cache: cord-103659-wpwfqhp2.txt plain text: cord-103659-wpwfqhp2.txt item: #623 of 2876 id: cord-103686-er8llst4 author: Carboni Bisso, I. title: Influenza season 2019: analysis of 143 hospitalized cases date: 2020-09-18 words: 2428 flesch: 43 summary: Also dyspnoea was more frequent in ICU patients (69.6% vs. 50.5%). In addition, elevation of serum transaminases was more frequently seen in ICU patients (37,5% vs. 8.0%), without associated involvement of alkaline phosphatase, bilirubin or prothrombin time. keywords: icu; influenza; license; medrxiv; patients; preprint cache: cord-103686-er8llst4.txt plain text: cord-103686-er8llst4.txt item: #624 of 2876 id: cord-103807-x4hrwhkz author: Prokop, J. W. title: Viral Induced Genetics Revealed by Multi-Dimensional Precision Medicine Transcriptional Workflow date: 2020-04-06 words: 6849 flesch: 43 summary: Using a combination of PAXgene tubes with ribosomal reduced RNAseq, we present here a dissection of both cellular and acellular RNA signatures of PICU MODS patients, suggesting utility for transcriptomics in precision medicine. The definition for MODS was taken from the original definition (56) in which among other criteria, MODS patients were clinically identified with two or more organs in failure. keywords: april; day; day0; elevation; fig; funder; genes; license; medrxiv; mods; organ; patient; perpetuity; preprint; rnaseq; samples; version cache: cord-103807-x4hrwhkz.txt plain text: cord-103807-x4hrwhkz.txt item: #625 of 2876 id: cord-104055-47ren7ie author: Lutkenhoff, Evan S. title: EEG power spectra and subcortical pathology in chronic disorders of consciousness date: 2020-09-01 words: 2481 flesch: 34 summary: The mixed-model analysis revealed a significant interaction (F (10, 1309.055) = 16.599, 10 p < 0.001) between diagnostic group (i.e., VS, MCS-, MCS+) and EEG features (i.e., 11 total power, delta, theta, alpha, beta, gamma frequency bands; see Figure 2 and Table 12 1), along with a significant main effect of diagnosis (F (2, 4389.124) = 5.158, p = Predicting DOC level from EEG spectral features 2 As shown in Figure 5a and Table 2 , diagnosis (i.e., VS vs. MCS) was predicted 3 significantly better by the model including EEG components, overall brain atrophy 4 (including both white matter and gray matter), and demographic components (i.e., age, and specificity (sens/spec; 0.79, 0.81, respectively) than both other models (AUC = 1 0.78, sens/spec 0.58/0.78 and AUC = 0.67, sens/spec 0.29/0.89 for the 2 demographics and atrophy and the demographic only models, respectively). In what follows, we address, in a large cohort 18 of patients with chronic DOC, the heretofore untested relationship between observed 19 electrocortical rhythms, patterns of subcortical brain atrophy (including thalamus, 20 brainstem, and basal ganglia), and clinical measures of awareness and arousal. keywords: atrophy; brain; consciousness; data; eeg; patients; power cache: cord-104055-47ren7ie.txt plain text: cord-104055-47ren7ie.txt item: #626 of 2876 id: cord-104180-f3hoz9bu author: Kirk-Bayley, Justin title: Recently published papers: inflammation, elucidation, manipulation? date: 2003-07-03 words: 1549 flesch: 37 summary: Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons Blockade of tissue factor: treatment for organ injury in established sepsis Development of ionized hypomagnesemia is associated with higher mortality rates Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experi-Critical Care Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial Prevention of endotracheal suctioning-induced alveolar derecruitment in acute lung injury Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best? Bad medicine: low-dose dopamine in the ICU On the physiologic and clinical relevance of lung-borne cytokines during ventilator-induced lung injury Discrepancies between perceptions by physicians and nursing staff of intensive care unit end-of-life decisions A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation Activated protein C inhibits the expression of platelet-derived growth factor in the lung Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant Impact of randomized trial results on acute lung injury ventilator therapy in teaching hospitals None declared. Looking at reduced endogenous steroid levels in sepsis, Marx and coworkers [2] focused on the androgens dehydroepiandrosterone (DHEA) and its sulphated precursor (DHEAS) and looked at disparity between survivors and nonsurvivors from severe sepsis. keywords: levels; lung; patients; sepsis cache: cord-104180-f3hoz9bu.txt plain text: cord-104180-f3hoz9bu.txt item: #627 of 2876 id: cord-104404-ytszpa4c author: Baig, Muhammad Akbar title: The COVID-19 Intubation and Ventilation Pathway (CiVP); a Commentary date: 2020-03-25 words: 655 flesch: 43 summary: Interim Clinical Guidance for Management of Patients with Confirmed Coronavirus Disease Outbreak of a new coronavirus: what anaesthetists should know Intubation and Mechanical Ventilation COVID-19: The Novel Coronavirus Prone Positioning in Severe Acute Respiratory Distress Syndrome Hypercapnia: is it protective in lung injury? Targeted therapeutic mild hypercapnia after cardiac arrest The National Heart L, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Arch Acad Emerg Med DOI: nan sha: doc_id: 104404 cord_uid: ytszpa4c nan In wake of the current COVID-19 pandemic, which has taken the world by storm, it is imperative to protect the health and safety of physicians and staff involved in acute management of COVID-19 patients. keywords: covid-19; patient; ventilation cache: cord-104404-ytszpa4c.txt plain text: cord-104404-ytszpa4c.txt item: #628 of 2876 id: cord-104467-elwfz1gk author: Kariyanna, Pramod Theetha title: A Systematic Review of COVID-19 and Myocarditis date: 2020-06-05 words: 3524 flesch: 50 summary: This systematic review found that the majority of COVID-19 myocarditis patients had cardiomegaly, pleural effusion and reduced LVEF. COVID-19 myocarditis affected patients over the age of 50 and incidences among both genders were equally reported. keywords: acute; case; covid-19; myocarditis; patients; review; studies; study cache: cord-104467-elwfz1gk.txt plain text: cord-104467-elwfz1gk.txt item: #629 of 2876 id: cord-104507-xx7t26rl author: Safari, Saeid title: Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Severe COVID-19 patients; a Narrative Review date: 2020-08-22 words: 3428 flesch: 20 summary: key: cord-104507-xx7t26rl authors: Safari, Saeid; Salimi, Alireza; Zali, Alireza; Jahangirifard, Alireza; Bastanhagh, Ehsan; Aminnejad, Reza; Dabbagh, Ali; Lotfi, Amir Hossein; Saeidi, Mohammad title: Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Severe COVID-19 patients; a Narrative Review date: 2020-08-22 journal: In Italy, the formal recommendation is made by the Italy Brescia Renal COVID Task Force and a publication by the Italian Society of Nephrology and ERA-EDTA, to specifically use CytoSorb in severe COVID-19 patients with Stage 3 renal failure on continuous renal replacement therapy (CRRT) (50) . keywords: covid-19; cytokine; hemoperfusion; mediators; patients; shock; syndrome; therapy; treatment cache: cord-104507-xx7t26rl.txt plain text: cord-104507-xx7t26rl.txt item: #630 of 2876 id: cord-138439-wvynetna author: Wei, Xiyi title: Sex Differences in Severity and Mortality Among Patients With COVID-19: Evidence from Pooled Literature Analysis and Insights from Integrated Bioinformatic Analysis date: 2020-03-30 words: 4729 flesch: 42 summary: Leung et al, 68 showed that in SARS patients, men were more likely to experience adverse events. 75 Anterior studies have reported that the high expression of ACE2 receptor in idiosyncratic organs of SARS patients pertains to the corresponding specific organ failure. keywords: ace2; analysis; cases; clinical; coronavirus; covid-19; data; male; patients; sars; sex; studies cache: cord-138439-wvynetna.txt plain text: cord-138439-wvynetna.txt item: #631 of 2876 id: cord-148109-ql1tthyr author: El-Din, Doaa Mohey title: E-Quarantine: A Smart Health System for Monitoring Coronavirus Patients for Remotely Quarantine date: 2020-05-05 words: 4621 flesch: 54 summary: The life cycle of smart health technique includes six main layers, cleaning data layer, anomaly detection layer, extracting features based on deep learning, LSTM deep learning layer, and fusion layer as shown in the lifecycle in Figure ( 2). Data fusion means the process to reach higher efficiency results to deal with multiple and heterogeneous data sources. keywords: data; fusion; health; layer; level; patients; rate; system; time cache: cord-148109-ql1tthyr.txt plain text: cord-148109-ql1tthyr.txt item: #632 of 2876 id: cord-158252-l43ztxsl author: Pawlowski, Colin title: Longitudinal laboratory testing tied to PCR diagnostics in COVID-19 patients reveals temporal evolution of distinctive coagulopathy signatures date: 2020-05-21 words: 6131 flesch: 30 summary: During each time window, we then compared the distribution of results from COVIDpos versus COVIDneg patients, allowing us to identify any lab tests which were significantly altered in COVIDpos patients during any time of disease acquisition, onset, and/or progression. With respect to erythrocytes, we found that both COVIDpos and COVIDneg patients developed a worsening mild anemia after PCR testing, but the trajectory was actually slower for COVIDpos patients (Figures 1B, 1H, Table 1 ). keywords: cohort; covid-19; covidneg; covidpos; diagnosis; lab; patients; platelet; test; testing; time cache: cord-158252-l43ztxsl.txt plain text: cord-158252-l43ztxsl.txt item: #633 of 2876 id: cord-184194-zdxebonv author: Chen, Lichin title: Using Deep Learning and Explainable Artificial Intelligence in Patients' Choices of Hospital Levels date: 2020-06-24 words: 4916 flesch: 44 summary: To address such maldistributed patient volume, it is essential to oversee patients choices before further evaluation of a policy or resource allocation. According to our result, three features could interpret the majority of patients' choices of hospital levels: the MFPC, LFPC, and physician density. keywords: care; data; features; health; hospital; learning; number; patients; providers; study cache: cord-184194-zdxebonv.txt plain text: cord-184194-zdxebonv.txt item: #634 of 2876 id: cord-204125-fvd6d44c author: Chowdhury, Muhammad E. H. title: An early warning tool for predicting mortality risk of COVID-19 patients using machine learning date: 2020-07-29 words: 3887 flesch: 44 summary: The prognostic model, nomogram and LNLCA score can help in early detection of high mortality risk of COVID-19 patients, which will help doctors to improve the management of patient stratification. key: cord-204125-fvd6d44c authors: Chowdhury, Muhammad E. H.; Rahman, Tawsifur; Khandakar, Amith; Al-Madeed, Somaya; Zughaier, Susu M.; Doi, Suhail A. R.; Hassen, Hanadi; Islam, Mohammad T. title: An early warning tool for predicting mortality risk of COVID-19 patients using machine learning date: 2020-07-29 journal: nan DOI: nan sha: doc_id: 204125 cord_uid: fvd6d44c COVID-19 pandemic has created an extreme pressure on the global healthcare services. keywords: coronavirus; covid-19; death; disease; group; mortality; patients; risk; score cache: cord-204125-fvd6d44c.txt plain text: cord-204125-fvd6d44c.txt item: #635 of 2876 id: cord-214006-0w6bqrox author: Aghdam, Atae Rezaei title: Towards Empowering Diabetic Patients: A perspective on self-management in the context of a group-based education program date: 2020-10-26 words: 4824 flesch: 39 summary: This is essentially a reality for people with chronic disease such as diabetes patients who need informational and emotional supports that allow them to be successful in their disease self-management (Litchman and Edelman 2019) . As such, this study aims to investigate the potential practices of online diabetes communities to address the following question; how can an online diabetes community empower patients in context of a Diabetes Group Education Program (DGEP)? keywords: communities; diabetes; health; management; ohcs; online; patients; program; self cache: cord-214006-0w6bqrox.txt plain text: cord-214006-0w6bqrox.txt item: #636 of 2876 id: cord-216974-0al3vdh1 author: Ravaud, Philippe title: Reconfiguring health services to reduce the workload of caregivers during the COVID-19 outbreak using an open-source scalable platform for remote digital monitoring and coordination of care in hospital Command Centres date: 2020-03-12 words: 1459 flesch: 46 summary: We describe how digital technologies may be used to automatically and remotely monitor patients at home. Patients answer simple self-reported questionnaires and their data is transmitted, in real time, to a Command Centre in the nearest reference hospital. keywords: command; covid-19; monitoring; patients cache: cord-216974-0al3vdh1.txt plain text: cord-216974-0al3vdh1.txt item: #637 of 2876 id: cord-217201-lvefk7qx author: Wang, Yang title: Ontology-based annotation and analysis of COVID-19 phenotypes date: 2020-08-05 words: 2487 flesch: 43 summary: In this study, we systematically annotated COVID-19 clinical phenotypes and comorbidities from journal and preprint articles, and applied HP to classify these phenotypes and examine the internal patterns. In terms of COVID-19 phenotype classification, CIDO has imported the HP representations of COVID-19-related phenotypes ( Figure 1 ) and comorbidities ( Figure 4 ). keywords: comorbidities; covid-19; disease; loss; patients; phenotypes cache: cord-217201-lvefk7qx.txt plain text: cord-217201-lvefk7qx.txt item: #638 of 2876 id: cord-225218-x32a4sp3 author: Filntisis, Panagiotis P. title: Identifying differences in physical activity and autonomic function patterns between psychotic patients and controls over a long period of continuous monitoring using wearable sensors date: 2020-10-30 words: 3314 flesch: 43 summary: key: cord-225218-x32a4sp3 authors: Filntisis, Panagiotis P.; Zlatintsi, Athanasia; Efthymiou, Niki; Kalisperakis, Emmanouil; Karantinos, Thomas; Lazaridi, Marina; Smyrnis, Nikolaos; Maragos, Petros title: Identifying differences in physical activity and autonomic function patterns between psychotic patients and controls over a long period of continuous monitoring using wearable sensors date: 2020-10-30 journal: nan DOI: nan sha: doc_id: In this paper, we present a rigorous statistical analysis of short-time features extracted from wearable data, during long-term continuous monitoring of patients with psychotic disorders and healthy control counterparts. keywords: analysis; controls; data; features; fractal; mean; patients; time cache: cord-225218-x32a4sp3.txt plain text: cord-225218-x32a4sp3.txt item: #639 of 2876 id: cord-244388-dxrrpxl7 author: Marchiori, Chiara title: Artificial Intelligence Decision Support for Medical Triage date: 2020-11-09 words: 4991 flesch: 42 summary: Built on case records and guidelines using AI-based methods, the system consists of the following building blocks: 1) an engine for the automated ingestion of unstructured clinical notes, the extraction of relevant medical entities and their organization into a knowledge graph (KG); 2) a data-driven dialog system that allows a conversation with such medical knowledge base and drives the patient interactions; 3) an inference engine able to suggest the most appropriate recommendation in terms of point of care and time frame for treatment. The pipeline consisted of the following stages: (1) data preprocessing for misspelling correction and abbreviation expansion, (2) named entity recognition (NER) and (3) concept clustering for the dynamic creation of an ontology of medical concepts from the corpus. keywords: case; concepts; data; input; learning; ontology; patient; recommendation; records; relations; symptoms; system cache: cord-244388-dxrrpxl7.txt plain text: cord-244388-dxrrpxl7.txt item: #640 of 2876 id: cord-251957-luw8m3eq author: Griffin, Claire L. title: Aortic Disease in the Time of COVID: Repercussions on Patient Care at an Academic Aortic Center date: 2020-04-30 words: 1403 flesch: 37 summary: 2 We have addressed these challenges by modifying 5 our surgical indications and work flow to accommodate the constraints of this new environment 6 while continuing to provide appropriate and timely surgical care for patients with aortic disease. More data are needed to 17 evaluate this question as patients with concomitant COVID-19 and aortic disease are identified 18 and followed. keywords: aortic; covid-19; disease; patients cache: cord-251957-luw8m3eq.txt plain text: cord-251957-luw8m3eq.txt item: #641 of 2876 id: cord-252013-ehyuflg3 author: Bozzani, Antonio title: ACUTE ARTERIAL AND DEEP VENOUS THROMBOEMBOLISM IN COVID-19 PATIENTS date: 2020-09-22 words: 2535 flesch: 34 summary: In particular, in relation to the known high incidence of DVT (25-31%) despite adequate prophylaxis 28 , we preferred to use an Istituto Superiore Sanità Italy Lessons learned during the COVID 19 virus pandemic Case-fatality rate and characteristics of patients dying in relation to COVID19 in Italy Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study The American College of Surgeons responds to COVID-19 Wick EC Rapid Response of an Academic Surgical Department to the COVID-19 Pandemic: Implications for Patients, Surgeons, and the Community Matthews CA Implementation Guide for Rapid Integration of an Outpatient Telemedicine Program During the COVID-19 Pandemic Disseminated Intravascular Coagulation and Thrombotic Microangiopathy-Either, Neither, or Both Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 Online ahead of print Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia COVID-19: coagulopathy, risk of thrombosis, and the rationale for anticoagulation Risk assessment of venous thromboembolism and bleeding in COVID-19 patients Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive Severe Acute Respiratory Syndrome Coronavirus 2 Infection and the Upper Limb Deep Vein Thrombosis Risk Acute limb ischemia in patients with COVID-19 pneumonia Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention Pharmacologic treatments for coronavirus disease 2019 Mild or Moderate Covid-19 Lip GYH ying with SARS-CoV-2 infection-an autopsy study of the first consecutive Lip GYH; Global COVID-19 Thrombosis Collaborative Group Tissue plasminogen activator (tPA) treatment for COVID-19 associated acuete respiratory distress syndrome (ARDS): case series J o u r n a l P r e -p r o AIM: Our aim was to report the experience of the Department of Vascular Surgery of Pavia (Lombardy), including the lessons learned and future perspectives regarding the management of COVID-19 patients who developed severe acute ischemia with impending lower limb loss or deep vein thrombosis (DVT). keywords: acute; arterial; covid-19; patients; thrombosis cache: cord-252013-ehyuflg3.txt plain text: cord-252013-ehyuflg3.txt item: #642 of 2876 id: cord-252060-cotsu82v author: Pericleous, Stephanos title: Coronavirus Disease 2019 Pandemic: Potential Collateral Damage on Patients With Operable Pancreatic Cancer date: 2020-06-23 words: 843 flesch: 37 summary: Several studies have demonstrated the adverse impact of delay to surgery in patients with pancreatic cancer. As a result of the COVID-19 pandemic, Kutikov et al 9 have proposed guidelines for triaging patients with various tumors, including pancreatic cancers. keywords: cancer; covid-19; patients cache: cord-252060-cotsu82v.txt plain text: cord-252060-cotsu82v.txt item: #643 of 2876 id: cord-252085-8dq3gdo8 author: Kaisy, Dr. Maythem Abdulhassan Al title: Chest Drain Insertion following Pneumothorax due to CPR in a COVID – 19 Patient. date: 2020-08-14 words: 1159 flesch: 41 summary: D) Because of airway obstruction, such patients require very low or no PEEP just like asthmatic patients to avoid air trapping. E) Because of high compliance, such patients need low tidal volume and low PEEP to provide better oxygenation. keywords: ards; chest; patients; pneumothorax cache: cord-252085-8dq3gdo8.txt plain text: cord-252085-8dq3gdo8.txt item: #644 of 2876 id: cord-252101-77lnyjan author: Mathanlal, Thasshwin title: ATMO-Vent: an adapted breathing atmosphere for COVID-19 patients date: 2020-09-26 words: 4339 flesch: 53 summary: The Laerdal (duck-bill) and Ambu based patient valves are widely used as non-return valves in Bag Valve Mask (BVM) based resuscitators owing to their simplicity and reliability [6] . Various modes of actuation have been proposed in various DIY ventilator designs such as gripping arm design of E-Vent [2] , compressed air in OxVent keywords: atmo; fig; flow; patient; pressure; sensor; step; valve; vent; ventilator; volume cache: cord-252101-77lnyjan.txt plain text: cord-252101-77lnyjan.txt item: #645 of 2876 id: cord-252159-6t35bxwv author: Ferraù, F. title: What we have to know about corticosteroids use during Sars-Cov-2 infection date: 2020-08-28 words: 5204 flesch: 26 summary: How to manage withdrawal of glucocorticoid therapy Radiation-induced hypopituitarism Fractionated stereotactic conformal radiotherapy for secreting and nonsecreting pituitary adenomas Safety and efficacy of fractionated stereotactic radiotherapy and stereotactic radiosurgery for treatment of pituitary adenomas: a systematic review and metaanalysis Pituitary dysfunction in adult patients after cranial radiotherapy: systematic review and meta-analysis Pituitary dysfunction following cranial radiotherapy for adult-onset nonpituitary brain tumours Pituitary insufficiency after infectious meningitis: a prospective study Pituitary abscess: clinical manifestations, diagnosis and treatment of 66 cases from a large pituitary center over 23 years COVID-19 infection and glucocorticoids: update from the Italian Society of Endocrinology Expert Opinion on steroid replacement in adrenal insufficiency Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic Iatrogenic Cushing's syndrome due to drug interaction between glucocorticoids and the ritonavir or cobicistat containing HIV therapies Inhaled corticosteroid use in HIV-positive individuals taking protease inhibitors: a review of pharmacokinetics, case reports and clinical management Iatrogenic Cushing syndrome and adrenal insufficiency during concomitant therapy with ritonavir and fluticasone Adrenal suppression in patients taking inhaled glucocorticoids is highly prevalent and management can be guided by morning cortisol Iatrogenic Cushing's Syndrome in an HIV-Infected patient treated with Inhaled corticosteroids (fluticasone propionate) and low dose ritonavir enhanced PI containing regimen Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature Iatrogenic cushing's syndrome with osteoporosis and secondary adrenal failure in human immunodeficiency virusinfected patients receiving inhaled corticosteroids and Ritonavir-Boosted protease inhibitors: six cases Cushing syndrome and severe adrenal suppression caused by fluticasone and protease inhibitor combination in an HIVinfected adolescent Adrenal insufficiency and exogenous Cushing's syndrome in a patient receiving inhaled fluticasone and ritonavir Inhaled Corticosteroids and Adrenal Insufficiency Fluticasone furoate induced iatrogenic Cushing syndrome in a pediatric patient receiving anti-retroviral therapy Iatrogenic Cushing's syndrome due to coadministration of Ritonavir and Inhaled Budesonide in an Asthmatic human immunodeficiency virus infected patient Adrenal insufficiency as a result of ritonavir and exogenous steroid exposure : report of 6 cases and recommendation for management Iatrogenic Cushing Syndrome in a 47-Year-Old HIV-positive woman on ritonavir and inhaled Budesonide Iatrogenic Cushing syndrome after intra-articular triamcinolone in a patient receiving ritonavir-boosted darunavir Cushingʼs syndrome and adrenal axis suppression in a patient treated with ritonavir and corticosteroid eye drops Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report Orbital floor triamcinolone causing Cushing's syndrome in a patient treated with Kaletra for HIV 1 Triamcinolone and ritonavir leading to druginduced Cushing syndrome and adrenal suppression: description of a new case and review of the literature Iatrogenic cushing syndrome and secondary adrenal insufficiency related to concomitant triamcinolone and ritonavir administration: a case report and review Ritonavir and epidural triamcinolone as a cause of iatrogenic cushing's syndrome Clinical course and management of iatrogenic Cushing's syndrome after co-administration of injected-triamcinolone and Ritonavir: a systematic review Cushing's syndrome due to interaction between ritonavir or cobicistat and corticosteroids: a case-control study in the French Pharmacovigilance Database Influence of antiretroviral drugs on the pharmacokinetics of prednisolone in HIV-infected individuals Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers Potential drugdrug interactions in HIV-infected children on antiretroviral ther Rilpivirine: a new non-nucleoside reverse transcriptase inhibitor Different effects of glucocorticoids on darunavir plasma concentrations Determinants of hydroxychloroquine blood concentration variations in systemic lupus erythematosus The effect of interferon-α on the expression of cytochrome P450 3A4 in human hepatoma cells Interferon gamma down-regulates cytochrome P450 3A genes in primary cultures of well-differentiated rat hepatocytes Interferon-α effects on diurnal hypothalamicpituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior Modulation of constitutive and inducible hepatic cytochrome(s) P-450 by interferon β in mice Acute interferon β-1b administration alters hypothalamic-pituitary-adrenal axis activity, plasma cytokines and leukocyte distribution in healthy subjects Acute and chronic neuroendocrine effects of interferon-beta 1a in multiple sclerosis The Italian Endo-COVID-19. Glucocorticoids (GCs), alone or associated to other drugs, were widely used in the management of patients affected by severe acute respiratory syndrome caused by SARS-CoV-2 infection, during the recent COVID-19 outbreak. keywords: adrenal; axis; covid-19; gcs; hpa; insufficiency; patients; ritonavir; syndrome; treatment cache: cord-252159-6t35bxwv.txt plain text: cord-252159-6t35bxwv.txt item: #646 of 2876 id: cord-252243-ua2w6xki author: Cooper, Emily title: Diagnosis and Management of UTI in Primary Care Settings—A Qualitative Study to Inform a Diagnostic Quick Reference Tool for Women Under 65 Years date: 2020-09-07 words: 8713 flesch: 52 summary: I get so many people coming back (with UTI symptoms) that I don't prescribe three days any more actually. There was discussion about what stage pyelonephritis and sepsis should be considered in a UTI consultation; some groups thought it should be excluded early on and others thought it should be ruled out after UTI symptoms were discussed. keywords: antibiotic; care; groups; management; patients; staff; symptoms; urine; use; uti; utis cache: cord-252243-ua2w6xki.txt plain text: cord-252243-ua2w6xki.txt item: #647 of 2876 id: cord-252279-0gozdv43 author: Pal, Amit title: Hydroxychloroquine and Covid-19: A Cellular and Molecular Biology Based Update date: 2020-06-10 words: 3866 flesch: 31 summary: Notably, in a mouse model of antiphospholipid syndrome, hydroxychloroquine treatment was associated with improvement in endothelial function [69, 70] . The exact molecular mechanisms by which DMARD hydroxychloroquine drug mediate their antithrombotic effects remain largely unknown and lay the platform for future prospective studies. keywords: cov-2; covid-19; disease; drugs; hydroxychloroquine; patients; sars; studies; syndrome; treatment; use cache: cord-252279-0gozdv43.txt plain text: cord-252279-0gozdv43.txt item: #648 of 2876 id: cord-252284-cgdcsazr author: Zeng, Jia-Hui title: First case of COVID-19 complicated with fulminant myocarditis: a case report and insights date: 2020-04-10 words: 1991 flesch: 44 summary: Lancet. 2020 Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis An experimental model for myocarditis and congestive heart failure after rabbit coronavirus infection Laboratory-confirmed respiratory infections as predictors of hospital admission for myocardial infarction and stroke: timeseries analysis of English data for A followup study of 69 discharged SARS patients Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus Pathological findings of COVID-19 associated with acute respiratory distress syndrome Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology An interferon-gamma-related cytokine storm in SARS patients Intermittent hypoxia causes inflammation and injury to human adult cardiac myocytes Prognostic value of electrocardiography in patients with fulminant myocarditis supported by percutaneous venoarterial extracorporeal membrane oxygenation-analysis from the CHANGE PUMP study Acknowledgements We thank the patient for granting us permission All available information is contained within the manuscript. COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. keywords: covid-19; heart; infection; myocarditis; patient; pneumonia cache: cord-252284-cgdcsazr.txt plain text: cord-252284-cgdcsazr.txt item: #649 of 2876 id: cord-252288-klkoerfn author: Zhang, Bicheng title: Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19 date: 2020-07-03 words: 3250 flesch: 47 summary: As shown in Table 1 , severe patients had higher inflammatory cytokines levels including IL-2, IL-6, and IL-10 than non-severe patients, especially in the NLR hi IgG hi or NLR hi IgG lo phenotype (p < 0.05). Furthermore, severe patients with NLR(hi)IgG(hi), NLR(hi)IgG(lo) had higher inflammatory cytokines levels including IL-2, IL-6 and IL-10, and decreased CD4+ T cell count compared to those with NLR(lo)IgG(lo) phenotype (p < 0.05). keywords: igg; levels; nlr; patients; response; sars cache: cord-252288-klkoerfn.txt plain text: cord-252288-klkoerfn.txt item: #650 of 2876 id: cord-252368-njlo6g78 author: Prasad, Aman title: Optimizing your telemedicine visit during the COVID‐19 pandemic: Practice guidelines for patients with head and neck cancer date: 2020-04-28 words: 2371 flesch: 48 summary: In otolaryngology, telemedicine has not been routinely used to evaluate patients, despite estimates that 62% of otolaryngology patients would be amenable to virtual appointments. key: cord-252368-njlo6g78 authors: Prasad, Aman; Brewster, Ryan; Newman, Jason G.; Rajasekaran, Karthik title: Optimizing your telemedicine visit during the COVID‐19 pandemic: Practice guidelines for patients with head and neck cancer date: 2020-04-28 journal: keywords: exam; neck; patients; physical; physicians; visit cache: cord-252368-njlo6g78.txt plain text: cord-252368-njlo6g78.txt item: #651 of 2876 id: cord-252374-obl6pfpf author: Zaninotto, Martina title: Cardiac troponin I in SARS-CoV-2-patients: the additional prognostic value of serial monitoring date: 2020-10-01 words: 2962 flesch: 22 summary: Aim of our study has been to investigate in COVID-19 patients the kinetics of release of cardiac troponin I and time course of its concentrations, measured with a high-sensitivity method (hs-TnI), in order to verify if serial measurements may provide additional and clinically useful information in identifying the underlying mechanisms of release and patients' risk stratification and prognosis. A review of typical CT findings and differential diagnosis Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients Myocardialinjury and COVID-19: Possible mechanisms Myocarditis in a patient with COVID-19: a cause of raised troponin and ECG changes High-sensitivity troponin I and incident coronary events, stroke, heart failure hospitalization, and mortality in the Atherosclerosis Risk in Communities (ARIC) study Association of repeatedly measured high-sensitivity-assayed troponin I with cardiovascular disease events in a general population from the MORGAM/BiomarCaRE Study Quantifying the Release of Biomarkers of Myocardial Necrosis From Cardiac Myocytes and Intact Myocardium ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) Long-term outcomes in patients with type 2 myocardial infarction and myocardial injury COVID-19 and cardiovascular disease Impact of cardiovascular disease and cardiac injury on in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis Association of coronavirus disease 2019 (covid-19) with myocardial injury and mortality Cardiac troponin for the diagnosis and risk-stratification of myocardial injury in COVID-19: JACC Review Topic of the Week Sample CRediT author statement Paper CCACTA-D-20-01705 Cardiac troponin I in SARS-CoV-2-patients: the additional prognostic value of serial monitoring conceptualization, methodology, data curation, writing, validation Males, n (%); Females, n (%) 80 Laboratory Findings (Table 1B) Biomarker, measuring unit (Reference Interval) White-cell count, 10 9 /L keywords: cardiac; covid-19; ctni; disease; patients; troponin cache: cord-252374-obl6pfpf.txt plain text: cord-252374-obl6pfpf.txt item: #652 of 2876 id: cord-252452-wwkw1uyi author: Rossi, Rosario title: Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action date: 2020-10-03 words: 1334 flesch: 39 summary: Particularly, the group of lipophilic statins demonstrated a significant reduction in mortality respect both patients who do not take statins, and patients who assumed hydrophilic statins (Fig. 1c ). In a recent study, no significant differences in statin chronic assumption were found in COVID-19 patients who developed a cardiac injury, even if this population showed an increased mortality risk in the brief period [11] . keywords: covid-19; patients; statins cache: cord-252452-wwkw1uyi.txt plain text: cord-252452-wwkw1uyi.txt item: #653 of 2876 id: cord-252473-i4pmux28 author: Rogers, Sharon title: Why can't I visit? The ethics of visitation restrictions – lessons learned from SARS date: 2004-08-31 words: 1911 flesch: 39 summary: The ethics of visitation restrictions – lessons learned from SARS date: 2004-08-31 journal: Crit Care DOI: 10.1186/cc2930 sha: doc_id: 252473 cord_uid: i4pmux28 Patients want, need and expect that their relatives will be able to visit them during inpatient admissions or accompany them during ambulatory visits. This reflection will facilitate future decision making with respect to visitation restrictions. keywords: health; restrictions; sars; visitation cache: cord-252473-i4pmux28.txt plain text: cord-252473-i4pmux28.txt item: #654 of 2876 id: cord-252506-8u9oiqoc author: Scarfò, Lydia title: COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus date: 2020-07-09 words: 4025 flesch: 33 summary: A novel coronavirus from patients with pneumonia in China Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Early detection of SARS-CoV-2 antibodies in COVID-19 patients as a serologic marker of infection Clinical and immunological features of severe and moderate coronavirus disease 2019 Weathering the COVID-19 storm: lessons from hematologic cytokine syndromes Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (nonepicenter): a nationwide analysis of China COVID-19 in persons with haematological cancers Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 outbreak Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study Survival study of hospitalised patients with concurrent COVID-19 and haematological malignancies CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report COVID-19 in a patient with chronic lymphocytic leukaemia Perturbation of the normal immune system in patients with CLL T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production Immunomodulatory effect of ibrutinib: reducing the barrier against fungal infections The BTK inhibitor ibrutinib may protect again pulmonary injury in COVID-19-infected patients Chronic lymphocytic leukemia management in italy during the COVID-19 Pandemic. The presence of three or more comorbidities was not significantly different in patients hospitalized with severe versus nonsevere disease; moreover, the presence of hypogammaglobulinemia, a frequent laboratory finding in CLL, did not show a relevant impact on the clinical course of COVID-19 patients, probably underscoring the relevance of the inflammatory reaction rather than the viral replication (and the capacity to clear it by antibody-mediated immune response) in shaping the severity of the disease. keywords: cases; cll; cov-2; covid-19; disease; patients; sars; study; treatment cache: cord-252506-8u9oiqoc.txt plain text: cord-252506-8u9oiqoc.txt item: #655 of 2876 id: cord-252531-i3b647wv author: Song, Zaiwei title: Hospital pharmacists’ pharmaceutical care for hospitalized patients with COVID-19: Recommendations and guidance from clinical experience date: 2020-04-03 words: 3542 flesch: 27 summary: Based on the Chinese perspective of centralizing COVID-19 patients and centralized inpatient treatment, the paper established a pharmaceutical care framework of COVID-19 hospitalized patients, including participating in making evidence-based decisions for medication, monitoring and evaluation of medication safety and efficacy, strengthened care for special population and patients with combined underlying diseases, monitoring and management of convalescent plasma therapy (CPT), providing emotional counselling and psychological support and providing scientific information about COVID-19 vaccines. Based on the Chinese perspective of centralizing COVID-19 patients and centralized inpatient treatment, the purpose of the paper is to establish an integrated strategy for pharmaceutical care services, which focus on COVID-19 hospitalized patients and hospital pharmacists. keywords: care; covid-19; drugs; hospital; patients; pharmaceutical; pharmacists; treatment cache: cord-252531-i3b647wv.txt plain text: cord-252531-i3b647wv.txt item: #656 of 2876 id: cord-252539-kx8ew3ap author: Riera, Jordi title: Extracorporeal Membrane Oxygenation Retrieval in Coronavirus Disease 2019: A Case-Series of 19 Patients Supported at a High-Volume Extracorporeal Membrane Oxygenation Center date: 2020-09-28 words: 2541 flesch: 40 summary: Then, patients were transferred to the ICU of the Vall d’Hebron University Hospital where they received support until respiratory improvement. After decannulation, patients were discharged for rehabilitation at the primary center. keywords: covid-19; ecmo; extracorporeal; membrane; oxygenation; patients cache: cord-252539-kx8ew3ap.txt plain text: cord-252539-kx8ew3ap.txt item: #657 of 2876 id: cord-252617-rqm0p19e author: Baker, Paul A. title: What’s inside the box? Or shall we think outside the box? date: 2020-08-28 words: 832 flesch: 41 summary: It is clear that there are many unanswered questions concerning airway barriers. Already, some hospitals have adopted the use of airway barriers in their recommendations and protocols. keywords: airway; barrier; intubation cache: cord-252617-rqm0p19e.txt plain text: cord-252617-rqm0p19e.txt item: #658 of 2876 id: cord-252687-7084pfqm author: Szelenberger, Rafal title: Ischemic Stroke among the Symptoms Caused by the COVID-19 Infection date: 2020-08-19 words: 7350 flesch: 34 summary: Despite the available clinical studies evaluating the potential role of hemostatis biomarkers (i.e., von Willebrand factor (vWF), P-selectin, fibrinogen, thrombomodulin, tissue factor, d-dimer, etc.) in ischemic stroke patients, the value of studied biomarkers is still unproven and requires further investigation [26] . Ischemic stroke patients mostly received thrombolytic therapy. keywords: acute; blood; brain; cells; coagulation; coronavirus; cov-2; covid-19; endothelium; infection; ischemic; patients; response; sars; stroke; symptoms; system cache: cord-252687-7084pfqm.txt plain text: cord-252687-7084pfqm.txt item: #659 of 2876 id: cord-252699-0xw9xvox author: de Marcaida, Joy Antonelle title: Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center date: 2020-09-18 words: 3440 flesch: 36 summary: On the other hand, Antonini and colleagues reported on the outcomes of 10 PD patients affected by COVID-19 at the Parkinson and Movement Disorders unit in Italy and at King's College Hospital in London, and suggested that PD patients, particularly those who are older and on advanced therapies, should be considered as a specifically susceptible group because of the high mortality rate noted for this subset of patients in their series [15] . Impact of the COVID-19 Pandemic on Parkinson's Disease and Movement Disorders The impact of the COVID-19 pandemic on Parkinson's disease: Hidden sorrows and emerging opportunities COVID-19: An Early Review of Its Global Impact and Considerations for Parkinson's Disease Patient Care The effect of frailty on survival in patients with COVID-19 (COPE): A multicentre, European, observational cohort study Multimorbidity and Frailty: Tackling Complexity in Parkinson's Disease SARS-CoV-2: At the Crossroad Between Aging and Neurodegeneration COVID-19 and Parkinson's Disease: Are We Dealing with Short-term Impacts or Something Worse? Parkinson's Disease and COVID-19: Perceptions and Implications in Patients and Caregivers Effects of COVID-19 on Parkinson's Disease Clinical Features: A Community-Based Case-Control Study Outcome of Parkinson's Disease Patients Affected by COVID-19 Clinical Presentation of COVID19 in Dementia Patients Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: Prospective observational cohort study Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease Neurological manifestations and complications of COVID-19: keywords: covid-19; disease; disorders; movement; parkinson; patients cache: cord-252699-0xw9xvox.txt plain text: cord-252699-0xw9xvox.txt item: #660 of 2876 id: cord-252751-prock3co author: Kalligeros, Markos title: Remdesivir Use Compared to Supportive Care in Hospitalized Patients with Severe COVID-19: A Single-Center Experience date: 2020-08-06 words: 3964 flesch: 46 summary: For the purposes of the present study we created a control group consisting of hospitalized patients with PCR confirmed COVID-19 who did not receive remdesivir. The US Food and Drug Administration issued an Emergency Use Authorization for remdesivir use in patients with severe COVID-19. keywords: covid-19; patients; remdesivir; study; time; trial; use cache: cord-252751-prock3co.txt plain text: cord-252751-prock3co.txt item: #661 of 2876 id: cord-252775-faxiem2w author: Tamagnini, Gabriele title: Cardiac surgery in the time of the novel coronavirus: Why we should think to a new normal date: 2020-07-15 words: 1724 flesch: 33 summary: http://orcid.org/0000-0003-0592-6585 Joseph Lamelas http://orcid.org/0000-0003-1570-1988 Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72, 314 cases from the Chinese center for disease control and prevention Cardiac involvement in COVID-19 patients: risk factors, predictors, and complications: a review COVID-19 Myocarditis and Severity Factors: An Adult Cohort Study Cardiovascular implications of fatal outcomes of patients with coronavirus disease Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) -China Trias-Llimos S Population age structure only partially explains the large number of COVID-19 deaths at the oldest ages At the heart of COVID-19 COVID-19 and multiorgan response Prevalence of underlying diseases in hospitalized patients with COVID-19: a systematic review and meta-analysis An acute respiratory infection runs into the most common noncommunicable epidemic-COVID-19 and cardiovascular diseases Epidemiology of acquired valvular heart disease Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database Heart Surgery Report 2018: the Annual Updated Registry of the German Society for Thoracic and Cardiovascular Surgery COVID-19 pandemic and cardiac imaging: We have to be prepared to preserve the safety of health care workers and hospital admitted patients, while having dedicated OR, ICU, and ward beds to treat COVID-19 patients: Indeed, the access to a proper and timely treatment cannot depend on the outcome of a swab. keywords: age; covid-19; diseases; patients; surgery cache: cord-252775-faxiem2w.txt plain text: cord-252775-faxiem2w.txt item: #662 of 2876 id: cord-252829-gn56tsz3 author: Higginson, Irene J. title: Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) date: 2020-11-03 words: 5792 flesch: 53 summary: Interestingly, IC costs were quite similar between our countries, in contrast to formal end of life care costs which varied much more [19] . key: cord-252829-gn56tsz3 authors: Higginson, Irene J.; Yi, Deokhee; Johnston, Bridget M.; Ryan, Karen; McQuillan, Regina; Selman, Lucy; Pantilat, Stephen Z.; Daveson, Barbara A.; Morrison, R. Sean; Normand, Charles title: Associations between informal care costs, care quality, carer rewards, burden and subsequent grief: the international, access, rights and empowerment mortality follow-back study of the last 3 months of life (IARE I study) date: 2020-11-03 journal: BMC Med DOI: 10.1186/s12916-020-01768-7 sha: doc_id: 252829 cord_uid: gn56tsz3 BACKGROUND: At the end of life, formal care costs are high. keywords: burden; care; costs; grief; icrs; life; palliative; patients; study cache: cord-252829-gn56tsz3.txt plain text: cord-252829-gn56tsz3.txt item: #663 of 2876 id: cord-252890-of29g89s author: Villarreal-Fernandez, Eduardo title: A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure date: 2020-06-12 words: 1023 flesch: 38 summary: Patient 1 was extubated at day 16, while the second patient was still intubated at day 19 (when this report was submitted) Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected Staff safety during emergency airway management for COVID-19 in Hong Kong Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/ H1N1v Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Not applicable. However, we reconsidered in other patients the rationale behind these early intubations and revisited the initial proposal of avoiding high flow oxygen in hypoxemic patients. keywords: intubation; patients cache: cord-252890-of29g89s.txt plain text: cord-252890-of29g89s.txt item: #664 of 2876 id: cord-252981-hywvmdjb author: Lockey, Stephen D. title: What’s Important: What Is Our Role in the COVID-19 Pandemic? date: 2020-04-10 words: 908 flesch: 48 summary: While social distancing and dedicated hygiene practices will help, the number of patients may exceed our system's capacity in several locations across the country. With more than 25,000 orthopaedic surgeons in practice in the United States 1 caring for patients of all ages and demographics, there are specific steps we can take in order to help the public prevent hospital visits and take extra precautions to remain safe while social distancing. keywords: care; patients; public cache: cord-252981-hywvmdjb.txt plain text: cord-252981-hywvmdjb.txt item: #665 of 2876 id: cord-253077-61fmul8c author: Vabret, Nicolas title: Immunology of COVID-19: current state of the science date: 2020-05-06 words: 20264 flesch: 30 summary: Tan et al. proposed a prognostic model based on lymphocyte counts at two time points: patients with less than 20% lymphocytes at days 10-12 from the onset of symptoms and less than 5% at days 17-19 had the worst outcomes in this study (Tan et al., 2020a) . Antibodies binding the SARS-CoV-2 internal N protein and the external S glycoprotein are commonly detected (Amanat et al., 2020; Ju et al., 2020; . keywords: 2020b; antibodies; antibody; blood; cd4; cells; coronavirus; cov-2; covid-19; covid-19 patients; cytokine; disease; et al; hcq; human; ifn; immune; infection; inflammatory; levels; lung; mers; patients; potential; protein; respiratory; responses; sars; sars coronavirus; severity; specific; studies; study; syndrome; t cells; treatment; vaccine cache: cord-253077-61fmul8c.txt plain text: cord-253077-61fmul8c.txt item: #666 of 2876 id: cord-253129-v5lck9l7 author: Kim, Kyeong Tae title: Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial date: 2020-02-01 words: 8906 flesch: 51 summary: The clinical data are collected by research nurses in the ICU and mechanical ventilation data and oxygenation (bedside monitor) data will be collected by researchers from the UC. Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. keywords: clinical; cure; data; elastance; lung; patients; peep; pressure; rct; recruitment; study; trial; ventilation cache: cord-253129-v5lck9l7.txt plain text: cord-253129-v5lck9l7.txt item: #667 of 2876 id: cord-253148-3t4o27xp author: Chow, Brian D.W. title: Evidence of human bocavirus circulating in children and adults, Cleveland, Ohio date: 2008-09-19 words: 2702 flesch: 46 summary: To define the clinical and epidemiologic characteristics in adult and pediatric patients with evidence of HBoV. STUDY DESIGN: From October 2005 through October 2006, we screened respiratory samples from children and adults negative for common respiratory pathogens for HBoV by PCR. The 12-18 month age group had the highest prevalence, with HBoV detected in 6.0% of respiratory samples screened (Fig. 2) . keywords: children; hbov; human; patients; pediatric; samples cache: cord-253148-3t4o27xp.txt plain text: cord-253148-3t4o27xp.txt item: #668 of 2876 id: cord-253168-b095rq5i author: Jiménez-Blanco Bravo, Marta title: Heart Failure in the Time of COVID-19 date: 2020-06-26 words: 1306 flesch: 48 summary: In this setting, heart failure units have faced an enormous challenge: taking care of their patients while at the same time avoiding patients' visits to the hospital. In this setting, heart failure units (HFU) have faced an enormous challenge: taking care of their patients while at the same time avoiding patients' visits to the hospital. keywords: heart; hospital; patients; visits cache: cord-253168-b095rq5i.txt plain text: cord-253168-b095rq5i.txt item: #669 of 2876 id: cord-253189-uba6dy08 author: Walker, Katie title: The evidence base for scribes and the disruptions of COVID-19 date: 2020-09-21 words: 1702 flesch: 51 summary: 13 Calculating the true productivity of physicians with scribes is inaccurate for this reason, biasing many studies against scribe programs. Surprisingly, there still remains limited peer-reviewed literature supporting scribes in health care despite rapid uptake of the role; the impact of the scribe role must be critically examined to inform health administrators and physicians who are considering employing scribes and developing scribe programs. keywords: impact; patient; physician; scribes cache: cord-253189-uba6dy08.txt plain text: cord-253189-uba6dy08.txt item: #670 of 2876 id: cord-253256-909chgl0 author: Bajwa, Sukhminder Jit Singh title: Peri-operative and critical care concerns in coronavirus pandemic date: 2020-03-28 words: 4550 flesch: 39 summary: In this scenario, it is prudent to follow the national and international guidelines and treat any suspected patient as positive and to take necessary precautions during anaesthesia and critical care of such patients. For any emergency surgery in such patients, planning of anaesthesia becomes very crucial while taking all the necessary precautions. keywords: care; cases; coronavirus; covid-19; health; infection; isolation; novel; patients; pressure; procedure; risk; transmission; use cache: cord-253256-909chgl0.txt plain text: cord-253256-909chgl0.txt item: #671 of 2876 id: cord-253295-82ydczid author: Funkhouser, William K. title: Pathology: the clinical description of human disease date: 2020-07-24 words: 8869 flesch: 30 summary: The Pathologist is that physician or clinical scientist who specializes in the art and science of medical risk estimation and disease diagnosis, using observations at the clinical, gross, body fluid, light microscopic, immunophenotypic, ultrastructural, cytogenetic, and molecular levels. As the human genome is deciphered, and as the complex interactions of cellular biochemistry are refined, risk of disease in unaffected individuals will be calculable, disease diagnosis will be increasingly accurate and prognostic, and molecular subsets of morphologically defined disease entities will be used to guide customized therapy for individual patients. keywords: abnormalities; blood; cell; century; development; diagnosis; disease; dna; etiology; example; function; history; human; neoplasms; pathogenesis; pathologist; pathology; patient; response; screening; therapy; tissue; understanding cache: cord-253295-82ydczid.txt plain text: cord-253295-82ydczid.txt item: #672 of 2876 id: cord-253375-m3qjj7r4 author: Perini, Guilherme Fleury title: How to manage lymphoid malignancies during novel 2019 coronavirus (CoVid-19) outbreak: a Brazilian task force recommendation date: 2020-04-17 words: 4319 flesch: 41 summary: Careful utilization of medical resources in the next months is warranted and we hope our review helps physicians decide, case by case, the optimal management of lymphoma patients. Management of patients with lymphoid malignancies can be challenging during the outbreak, due to need of multiple hospital visits and admissions, immunosuppression and need for chemotherapy, radiotherapy and stem cell transplantation. keywords: cell; chop; covid-19; lymphoma; patients; phase; risk; rituximab; therapy; treatment cache: cord-253375-m3qjj7r4.txt plain text: cord-253375-m3qjj7r4.txt item: #673 of 2876 id: cord-253402-6sgeraws author: Remuzzi, Andrea title: COVID-19 and Italy: what next? date: 2020-03-13 words: 2848 flesch: 51 summary: The value of the exponent can be computed as r=0·225 (1 per day) and is consistent with the number of infected patients reported by the Italian Health Ministry. If the increase in the number of infected patients follows this trend for the next week, there will be more than 30 000 patients infected by March 15, as shown in figure 1B . keywords: care; health; italy; number; patients cache: cord-253402-6sgeraws.txt plain text: cord-253402-6sgeraws.txt item: #674 of 2876 id: cord-253417-ihi67m1u author: Paleri, Vinidh title: Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration date: 2020-05-11 words: 3535 flesch: 44 summary: When applied to the health care sector these measures should aim to reduce hospital attendance by triaging out low risk patients both to protect clinicians and hospitalized patients, while still allowing timely investigations on those deemed to be at higher risk. key: cord-253417-ihi67m1u authors: Paleri, Vinidh; Hardman, John; Tikka, Theofano; Bradley, Paula; Pracy, Paul; Kerawala, Cyrus title: Rapid implementation of an evidence‐based remote triaging system for assessment of suspected referrals and patients with head and neck cancer on follow‐up after treatment during the COVID‐19 pandemic: Model for international collaboration date: 2020-05-11 journal: keywords: assessment; cancer; care; data; head; neck; patients; risk; triaging cache: cord-253417-ihi67m1u.txt plain text: cord-253417-ihi67m1u.txt item: #675 of 2876 id: cord-253456-u9num2o9 author: Zhang, Che title: Clinical and epidemiological characteristics of pediatric SARS-CoV-2 infections in China: A multicenter case series date: 2020-06-16 words: 4545 flesch: 45 summary: However, information on pediatric patients is limited. We describe the clinical and epidemiological characteristics of pediatric patients to provide valuable insight into the early diagnosis and assessment of COVID-19 in children. keywords: cases; clinical; covid-19; data; lesions; patients; sars cache: cord-253456-u9num2o9.txt plain text: cord-253456-u9num2o9.txt item: #676 of 2876 id: cord-253638-5f9ofdsc author: Alsaied, Tarek title: Coronavirus Disease 2019 (COVID‐19) Pandemic Implications in Pediatric and Adult Congenital Heart Disease date: 2020-06-10 words: 5693 flesch: 42 summary: Arrhythmia is also commonly seen in COVID-19 patients and while nonspecific, palpitations are one of the presenting symptoms in 7% of the patients 31, 44, 54 . There is no information to suggest any harmful effect in COVID-19 patients thus it is reasonable to continue these medications. keywords: article; cardiovascular; care; cases; copyright; coronavirus; covid-19; disease; heart; patients; rights; risk cache: cord-253638-5f9ofdsc.txt plain text: cord-253638-5f9ofdsc.txt item: #677 of 2876 id: cord-253704-y0t30xw3 author: Lahiri, Durjoy title: COVID-19 Pandemic: A Neurological Perspective date: 2020-04-29 words: 4350 flesch: 36 summary: The most vital clinical information which we gather is that impaired consciousness may be a presenting feature of COVID-19, and therefore, a high index of suspicion for such patients will be the key to prevent or, at least, lessen exposure to health care providers and other patients. Another very recent report describes the occurrence of acute hemorrhagic necrotizing encephalopathy in COVID-19 patient [15] . keywords: acute; cases; coronavirus; covid-19; features; infection; involvement; patients; sars cache: cord-253704-y0t30xw3.txt plain text: cord-253704-y0t30xw3.txt item: #678 of 2876 id: cord-253730-cdkzvfib author: Suzuki, Emily title: Assessment of the Need for Early Initiation of Rehabilitation Treatments in Patients with Coronavirus Disease 2019 date: 2020-08-13 words: 3458 flesch: 41 summary: Resources for rehabilitation of patients with COVID-19 are limited, and no report has described the rehabilitation of moderate to severe COVID-19 patients in the acute phase. Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations Covid-19 and post intensive care syndrome: a call for action COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure Hypercoagulability of COVID-19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Clinical observation and management of COVID-19 patients British Thoracic Society Standards of Care Committee Pulmonary Embolism Guideline Development Group: British Thoracic Society guidelines for the management of suspected acute pulmonary embolism Investigation of the freely available easyto-use software 'EZR' for medical statistics Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease Watching television and risk of mortality from pulmonary embolism among Japanese men and women Physical inactivity and idiopathic pulmonary embolism in women: prospective study Clinical features of patients infected with 2019 novel coronavirus in China Medical Treatment Expert Group for Covid-19: keywords: covid-19; hospital; patients; rehabilitation; risk; ventilation cache: cord-253730-cdkzvfib.txt plain text: cord-253730-cdkzvfib.txt item: #679 of 2876 id: cord-253746-15w4gquq author: Goldman, Michel title: Reflections on the Collaborative Fight Against COVID-19 date: 2020-09-17 words: 1633 flesch: 33 summary: It is therefore important that patient organizations are involved early on in the design of clinical trials. Finally, as discussed in the next section, patients should now be invited to take an active role in the design of COVID-19 trials. keywords: covid-19; interventions; patients; trials cache: cord-253746-15w4gquq.txt plain text: cord-253746-15w4gquq.txt item: #680 of 2876 id: cord-253862-jl1zhg13 author: Khalaf, Khalil title: SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment date: 2020-10-06 words: 14633 flesch: 37 summary: A cohort study Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Use of convalescent plasma therapy in SARS patients in Hong Kong Treatment with convalescent plasma for influenza A (H5N1) infection Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Effectiveness of convalescent plasma therapy in severe COVID-19 patients Treatment of 5 critically Ill patients with COVID-19 with convalescent plasma Safety update: COVID-19 convalescent plasma in 20,000 hospitalized patients Severe acute respiratory syndrome coronavirus viroporin 3A activates the NLRP3 inflammasome The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China Biology of IL-38 and its role in disease IL-37 is a fundamental inhibitor of innate immunity Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by COVID-19 (CoV-19 or SARS-CoV-2): anti-inflammatory strategies Baricitinib as potential treatment for 2019-nCoV acute respiratory disease Use of baricitinib in patients with moderate and severe COVID-19 Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants Neutralizing epitopes of the SARS-CoV S-protein cluster independent of repertoire, antigen structure or mAb technology Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: target, mechanism of action, therapeutic potential Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19) Similar to SARS, infected patients presented with a variety of clinical courses, from mild upper respiratory symptoms to fulminant pneumonia and multi-organ system failure. keywords: acute; antibodies; antibody; antiviral; cells; coronavirus; cov-2; covid-19; disease; et al; group; host; human; infection; novel; patients; protein; receptor; respiratory; rna; sars; study; syndrome; treatment; trial; use cache: cord-253862-jl1zhg13.txt plain text: cord-253862-jl1zhg13.txt item: #681 of 2876 id: cord-253886-4b3i30hi author: Isakov, Alexander title: Transport and Management of Patients With Confirmed or Suspected Ebola Virus Disease date: 2015-05-21 words: 3694 flesch: 37 summary: However, the transport of the first patient with confirmed Ebola virus disease to the United States (Atlanta, GA), the transport of the first US-diagnosed Ebola virus disease case (Dallas, TX), and the first transmission of Ebola virus disease to health care workers in the United States understandably raised anxiety in the EMS community about the appropriate education and training, policies, and procedures, as well as supervision required, to be best prepared for transporting patients with serious communicable disease in the United States. EMS and other US health care professionals lack familiarity with Ebola virus disease, 1 which is understandable. keywords: care; disease; ebola; ems; patients; transport; virus cache: cord-253886-4b3i30hi.txt plain text: cord-253886-4b3i30hi.txt item: #682 of 2876 id: cord-253962-ug7yflxh author: Huang, Dong title: A novel risk score to predict diagnosis with Coronavirus Disease 2019 (COVID‐19) in suspected patients: A retrospective, multi‐center, observational study date: 2020-06-08 words: 2463 flesch: 53 summary: 4 Respiratory failure, immunosuppression, as well as systemic infection and inflammation are already recognized as main clinical characteristics of COVID-19 patients. However, given the incidence of RT-PCR false-negative results, shortage of PCR kit, and possible delayed diagnosis due to timeconsuming process of RT-PCR, 6 an early efficient identification of confirmed COVID-19 patients is important for early diagnosis and treatments. keywords: covid-19; diagnosis; patients; risk; score; study cache: cord-253962-ug7yflxh.txt plain text: cord-253962-ug7yflxh.txt item: #683 of 2876 id: cord-253970-sbj869yy author: Agarwal, Amit title: Neurological emergencies associated with COVID-19: stroke and beyond date: 2020-08-11 words: 2423 flesch: 35 summary: COVID-19 neurologic complication with CNS vasculitis-like pattern Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in The emerging threat of (micro)thrombosis in COVID-19 and its therapeutic implications Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Hypercoagulability in COVID-19: identification of arterial and venous thromboembolism in the abdomen, pelvis, and lower extremities The immunology of COVID-19: is immune modulation an option for treatment? Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 To our knowledge, this was the first study to systematically characterize neurological symptoms and neuroimaging findings in COVID-19 patients. keywords: complications; covid-19; manifestations; patients; stroke; syndrome cache: cord-253970-sbj869yy.txt plain text: cord-253970-sbj869yy.txt item: #684 of 2876 id: cord-254025-j1l0mder author: de Melo, Andreia C. title: Cancer inpatients with COVID-19: A report from the Brazilian National Cancer Institute date: 2020-10-26 words: 3385 flesch: 46 summary: Therefore, the overall COVID-19-related mortality rate reached almost one third of the cases (60 [33.1%]), which was higher than that reported by other series with cancer patients [7, 8, 10, 12, 14] , and far exceeding the mortality reported for non-cancer patients [5] . There was no paired sample with non-cancer patients with COVID-19 or cancer patients without COVID-19 to provide a better comparison between the outcomes of morbidity and mortality. keywords: cancer; cases; covid-19; death; mortality; patients; study cache: cord-254025-j1l0mder.txt plain text: cord-254025-j1l0mder.txt item: #685 of 2876 id: cord-254040-s3k51rkk author: Bombaci, Alessandro title: Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail date: 2020-10-06 words: 2144 flesch: 28 summary: In this commentary, we briefly discuss the digital tools to remotely monitor and manage ALS patients. Herein, we briefly review the available instruments to remotely manage ALS patients with the aim of proposing a digital toolset (Fig.1 ) to face the current imposed stay-home policy. keywords: als; covid-19; disease; patients; sclerosis; telemedicine cache: cord-254040-s3k51rkk.txt plain text: cord-254040-s3k51rkk.txt item: #686 of 2876 id: cord-254072-evgw0as5 author: Hsu, Li-Yang title: Severe Acute Respiratory Syndrome (SARS) in Singapore: Clinical Features of Index Patient and Initial Contacts date: 2003-06-17 words: 2242 flesch: 49 summary: To this end, we are collecting serum from healthcare staff exposed to SARS patients. Evidence from randomized controlled trials is needed before the use of ribavirin can be advocated for routine use in SARS patients. keywords: chest; day; days; index; patients; sars cache: cord-254072-evgw0as5.txt plain text: cord-254072-evgw0as5.txt item: #687 of 2876 id: cord-254148-wc762p6v author: Prell, Tino title: Recommendations for Standards of Network Care for Patients with Parkinson’s Disease in Germany date: 2020-05-13 words: 5351 flesch: 37 summary: In the meantime, in Germany, several university clinics with a PD focus have established this or a similar PD day clinic concept to close the gap in PD care that have been found to be a transnational issue [26] [27] [28] . Rural location, nursing home residence, and the presence of physical or cognitive impairment are common reasons for limited access to specialized PD health care keywords: care; disease; germany; gmbh; health; management; network; parkinson; patients; specialists; symptoms; treatment cache: cord-254148-wc762p6v.txt plain text: cord-254148-wc762p6v.txt item: #688 of 2876 id: cord-254269-x8vpnhd2 author: Hakim, Abraham A. title: Implications for the use of telehealth in surgical patients during the COVID-19 pandemic date: 2020-04-21 words: 1322 flesch: 44 summary: key: cord-254269-x8vpnhd2 authors: Hakim, Abraham A.; Kellish, Alec S.; Atabek, Umur; Spitz, Francis R.; Hong, Young K. title: Implications for the use of telehealth in surgical patients during the COVID-19 pandemic date: 2020-04-21 journal: Am J Surg DOI: 10.1016/j.amjsurg.2020.04.026 sha: doc_id: Presented in this paper is a review describing the application of telemedicine in caring for surgical patients, and methods for potential implications of telehealthcare for surgical patients during the COVID-19 pandemic. keywords: covid-19; pandemic; patients; telehealth cache: cord-254269-x8vpnhd2.txt plain text: cord-254269-x8vpnhd2.txt item: #689 of 2876 id: cord-254357-5s84kimn author: Morse, Alan R title: Decreasing Avoidable Vision Loss: Identifying Antecedents of Adherence date: 2020-11-02 words: 2938 flesch: 26 summary: Adherence to medication The relationship between glaucoma medication adherence, eye drop technique and visual field defect severity Toward identifying the causes and combinations of causes increasing the risks of nonadherence to medical regimens: combined results of two German self-report surveys Health literacy and adherence to medical treatment in chronic and acute illness: a meta-analysis Barriers to follow-up and strategies to improve adherence to appointments for care of chronic eye diseases Understanding non-adherence from the inside: hypertensive patients' motivations for adhering and not adhering Patients' beliefs about treatment: the hidden determinant of treatment outcome? Depression and literacy are important factors for missed appointments Electronic monitoring to assess adherence with once-daily glaucoma medications and risk factors for nonadherence: the automated dosing reminder study Predicting adherence with the glaucoma treatment compliance assessment tool Cost-related medication underuse among chronically iII adults: the treatments people forgo, how often, and who is at risk Patient-reported behavior and problems in using glaucoma medications Patient-physician communication on medication cost during glaucoma visits The incidence and determinants of primary nonadherence with prescribed medications in primary care Adherence with topical glaucoma medication monitored electronically: the Travatan dosing aid study Help needed in medication self-management for people with visual impairment: case-control study Association of visit adherence and visual acuity in patients with neovascular age-related macular degeneration: secondary analysis of the comparison of age-related macular degeneration treatment trial The association between medication adherence and visual field progression in the collaborative initial glaucoma treatment study Open-angle glaucoma Comparing adherence and persistence across 6 chronic medication classes Patterns of glaucoma medication over four years of follow-up on behalf of the MARINA Study Group. Fear of blindness in the collaborative initial glaucoma treatment study: patterns and correlates over time Association of treatment adherence with real-life VA outcomes in AMD, DME, and BRVO patients Risk factors for discontinuation of treatment for neovascular age-related macular degeneration A retrospective study of the real-life utilization and effectiveness of ranibizumab therapy for neovascular age-related macular degeneration in the UK Four-year treatment results of neovascular age-related macular degeneration with ranibizumab and causes for discontinuation of treatment Is patient empowerment the key to promote adherence? keywords: adherence; glaucoma; loss; patients; treatment; vision cache: cord-254357-5s84kimn.txt plain text: cord-254357-5s84kimn.txt item: #690 of 2876 id: cord-254377-j8e8gb0l author: Ali, Sadaf title: Acute cor pulmonale from saddle pulmonary embolism in a patient with previous Covid-19 – should we prolong prophylactic anticoagulation? date: 2020-06-13 words: 1451 flesch: 29 summary: Clinical Characteristics of Coronavirus Disease 2019 in China Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study Acute Cor Pulmonale in Critically Ill Patients with Covid-19 High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up Chinese expert consensus on diagnosis and treatment of coagulation dysfunction in COVID-19 Thrombolytic therapy for pulmonary embolism MARVELOUS Collaborators. We report the case of a 52-year old woman, who presented with massive saddle pulmonary embolism after one week of initial hospital discharge, successfully thrombolysed that raises the question of consideration of extended prophylactic anticoagulation even in low risk Covid-19 cases. keywords: acute; covid-19; patients; risk; thromboembolism cache: cord-254377-j8e8gb0l.txt plain text: cord-254377-j8e8gb0l.txt item: #691 of 2876 id: cord-254382-xy8se56o author: Santos, C. title: Comparative Incidence and Outcomes of COVID-19 in Kidney or Kidney-Pancreas Transplant Recipients Versus Kidney or Kidney-Pancreas Waitlisted Patients: A Pilot Study date: 2020-07-25 words: 3663 flesch: 35 summary: We hypothesize that these patients have an incidence proportion of COVID-19 similar to the general population, but that transplanted patients have greater occurrences of hospitalization, intensive care unit admission, mechanical ventilation and death compared to waitlisted patients due to chronic immunosuppression. Supplementary oxygen was provided to 36% of transplanted patients, and 33% of waitlisted patients. keywords: covid-19; kidney; medrxiv; pancreas; patients; preprint; transplanted cache: cord-254382-xy8se56o.txt plain text: cord-254382-xy8se56o.txt item: #692 of 2876 id: cord-254419-qw83atrx author: Bhattacharyya, Rajat title: The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review date: 2020-08-25 words: 5908 flesch: 29 summary: Statins, another group of drugs that have anti-inflammatory and antithrombotic properties, have also been studied in COVID-19 patients; a retrospective study showed a favorable recovery profile and lower all-cause mortality with the use of statins in 1219 hospitalized patients with COVID-19 A pilot trial of adding tocilizumab therapy in patients with severe COVID-19 disease in combination with standard therapy of lopinavir, methylprednisolone, and oxygen therapy showed remarkable short-term clinical responses in 20 out of 21 patients within 2 weeks of tocilizumab therapy [57] . keywords: acute; anticoagulation; cells; coronavirus; covid-19; disease; failure; infection; inflammatory; patients; pulmonary; study; thrombosis; trials cache: cord-254419-qw83atrx.txt plain text: cord-254419-qw83atrx.txt item: #693 of 2876 id: cord-254428-n0uwy77g author: Zhao, Wen title: Clinical characteristics and durations of hospitalized patients with COVID-19 in Beijing: a retrospective cohort study date: 2020-03-17 words: 3393 flesch: 48 summary: In terms of discharged patients, times of illness onset to discharge and of exposure point to discharge (available in 21 patients) were 18.5 (15) (16) (17) (18) (19) (20) (21) (22) and 23 (17-25) days, respectively. In conclusion, the average hospital length of stay is 13 days for discharged patients with COVID-19; average time of clinical course is 23 days. keywords: covid-19; days; duration; hospital; patients; study cache: cord-254428-n0uwy77g.txt plain text: cord-254428-n0uwy77g.txt item: #694 of 2876 id: cord-254446-yxqbe1dj author: Ren, Yunzhao R. title: A Comprehensive Updated Review on SARS‐CoV‐2 and COVID‐19 date: 2020-05-29 words: 6750 flesch: 32 summary: One study reported that IFN-γ, TNF-α, IL-1β, and IL-8 plasma concentrations in COVID-19 patients were significantly higher compared to results from four healthy In addition to the consistent trend of lower lymphocyte counts observed in severe cases of COVID-19 (Table 3 ) from different studies, total T cells, CD4 + T cells, and CD8 + T cells also were significantly lower in severe/critical COVID-19 cases than in non-severe cases 124, 127, 128 . They also found that CD8 + T cells in COVID-19 patients exhibit many aspects of exhaustion and reduced function, such as Once in the cell, the virus is not killed or neutralized; instead, it may continue to replicate, and/or stimulate or kill the target cells, causing more inflammation and damage. keywords: analysis; cases; china; coronavirus; cov-2; covid-19; days; disease; infection; novel; patients; pneumonia; review; sars; study; syndrome; transmission cache: cord-254446-yxqbe1dj.txt plain text: cord-254446-yxqbe1dj.txt item: #695 of 2876 id: cord-254478-scc9wee0 author: To, Kelvin Kai-Wang title: Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study date: 2020-03-23 words: 5195 flesch: 46 summary: A patient's reluctance to provide a sample can account for the paucity of timepoints in viral load studies of respiratory virus infections. Older age was correlated with higher viral load (Spearman's ρ=0·48, 95% CI 0·074–0·75; p=0·020). keywords: antibody; coronavirus; cov-2; load; onset; patients; saliva; samples; sars; specimens; study; symptom cache: cord-254478-scc9wee0.txt plain text: cord-254478-scc9wee0.txt item: #696 of 2876 id: cord-254494-wbfgrez1 author: Shi, Chunhong title: Barriers to Self-Management of Type 2 Diabetes During COVID-19 Medical Isolation: A Qualitative Study date: 2020-10-14 words: 5755 flesch: 39 summary: The purpose of this study was to explore perceived barriers among type 2 diabetes patients during isolation following their recovery from COVID-19. Perceived barriers to diabetes self-management described by diabetes patients indicated a lack of environmental resources and support strategies to meet their needs. keywords: barriers; blood; covid-19; diabetes; isolation; management; participants; patients; self; study; support cache: cord-254494-wbfgrez1.txt plain text: cord-254494-wbfgrez1.txt item: #697 of 2876 id: cord-254595-by2j7byz author: Rao, Sandesh S. title: Establishing Telemedicine in an Academic Total Joint Arthroplasty Practice: Needs and Opportunities Highlighted by the COVID-19 Pandemic date: 2020-04-23 words: 959 flesch: 40 summary: During 292 crises such as the COVID-19 pandemic, when healthcare access is limited and mobility is 293 impaired, telemedicine allows providers to continue delivering quality patient care while 294 avoiding unnecessary risks to themselves, the care team, and their patients. We review key components relevant to the establishment and effective use of telemedicine, focused on patient education, practice logistics, technological considerations, and sensitive patient health information–associated compliance factors, which are necessary to provide care remotely for total joint arthroplasty patients. keywords: care; healthcare; patients; telemedicine cache: cord-254595-by2j7byz.txt plain text: cord-254595-by2j7byz.txt item: #698 of 2876 id: cord-254777-h8hw4m9f author: Tanner, Tamara title: Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 date: 2020-07-29 words: 4735 flesch: 38 summary: The Lancet Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia Translating IL-6 biology into effective treatments Interleukin-6 as a therapeutic target Effective treatment of severe COVID-19 patients with tocilizumab Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients Interleukin-6 blockade for severe COVID-19. Similarly, an observational cohort study from the United States (US) describes shortness of breath, fever and cough as the most common presenting symptoms of patients hospitalized with COVID-19 infection keywords: children; coronavirus; covid-19; cytokine; disease; il-6; infection; patients; sars; treatment; use cache: cord-254777-h8hw4m9f.txt plain text: cord-254777-h8hw4m9f.txt item: #699 of 2876 id: cord-254852-qr5gdmbc author: Grief, Samuel N. title: Guidelines for the Evaluation and Treatment of Pneumonia date: 2018-08-14 words: 4735 flesch: 33 summary: Systematic review and meta-analysis Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study Antibiotics for community-acquired pneumonia in adult outpatients Duration of antibiotic treatment in community-acquired pneumonia Corticosteroids for pneumonia Corticosteroid therapy for patients hospitalized with community-acquired pneumonia Corticosteroids in the adjunctive therapy of communityacquired pneumonia: an appraisal of recent meta-analyses of clinical trials Procalcitonin-guided diagnosis and antibiotic stewardship revisited Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections Unresolved Acute Pneumonia: a BAD OMEN Pneumococcal vaccination j what you should know j CDC Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults Updated recommendations for prevention of invasive pneumococcal disease among adults using the 23-valent pneumococcal polysaccharide vaccine (PPSV23) Vaccines for preventing pneumococcal infection in adults What is the best approach to the nonresponding patient with community-acquired pneumonia? Pulmonary infections in the returned traveler Non-infectious mimics of community-acquired pneumonia Uncomplicated pneumonia treatment in the outpatient setting usually should last 5 to 10 days. keywords: adults; antibiotic; children; community; infection; patients; pneumonia; risk; symptoms; treatment; years cache: cord-254852-qr5gdmbc.txt plain text: cord-254852-qr5gdmbc.txt item: #700 of 2876 id: cord-254990-nrzwn6oz author: Mayer, Kirby P. title: Recovery from COVID-19 and acute respiratory distress syndrome: the potential role of an intensive care unit recovery clinic: a case report date: 2020-09-10 words: 3124 flesch: 43 summary: Coronavirus disease 2019 (COVID-19) pandemic Reference equations for the six-minute walk in healthy adults Survival rate in acute kidney injury superimposed COVID-19 patients: a systematic review and meta-analysis Implementation of an ICU recovery clinic at a tertiary care academic center Comprehensive care of ICU survivors: development and implementation of an ICU recovery center CE: critical care recovery center: an innovative collaborative care model for ICU survivors The ICU follow-up clinic: a new paradigm for intensivists Chaos theory: optimizing critical illness outcomes through the family experience -a theoretical review Clinical practice guidelines for support of the family in the patient-centered intensive care unit: American College of Critical Care Medicine Task Force Family response to critical illness: postintensive care syndrome -family Key components of ICU recovery programs: what did patients report provided benefit? Physical function impairment in survivors of critical illness in an ICU recovery clinic Understanding, compliance and psychological impact of the SARS quarantine experience The psychological impact of quarantine and how to reduce it: rapid review of the evidence Comprehensive review of mask utility and challenges during the COVID-19 pandemic Public health measures and the reproduction number of SARS-CoV-2 Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study Physical complications in acute lung injury survivors: a two-year longitudinal prospective study Functional disability 5 years after acute respiratory distress syndrome Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study Co-occurrence of post-intensive care syndrome problems among 406 survivors of critical illness Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19 Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations The purpose of this case report is to highlight the potential role of intensive care unit recovery or follow-up clinics for patients surviving acute hospitalization for coronavirus disease 2019. keywords: care; clinic; covid-19; day; follow; icu; patient; recovery; unit cache: cord-254990-nrzwn6oz.txt plain text: cord-254990-nrzwn6oz.txt item: #701 of 2876 id: cord-254993-bndl93qr author: Sonnweber, Thomas title: Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study date: 2020-10-21 words: 3690 flesch: 34 summary: It has been suggested that the COVID-19 related inflammation may be the main cause of COVID-19 associated iron disorders, as an inflammation-driven dysregulation of iron homeostasis is well established [4, 6, 7] . Inflammation, therefore, causes alterations of iron homeostasis hallmarked by functional iron deficiency (ID) as reflected by high iron content in reticuloendothelial cells and consequently high serum ferritin levels whereas circulating iron levels are low. keywords: covid-19; disease; expression; ferritin; homeostasis; hyperferritinemia; inflammation; iron; patients; serum cache: cord-254993-bndl93qr.txt plain text: cord-254993-bndl93qr.txt item: #702 of 2876 id: cord-255037-i9guxtix author: Reda, Gianluigi title: Reply to “CLL and COVID-19 at the Hospital Clinic of Barcelona: an interim report” Analysis of six hematological centers in Lombardy: On behalf of CLL commission of Lombardy Hematology Network (REL) date: 2020-08-04 words: 1181 flesch: 33 summary: Focusing on ibrutinib patients, subjects were mainly males (75%) with a median age at infection onset of 65 years (range 55-75). [1] , reporting the first attempt to determine the prevalence of COVID-19 in the monocentric cohort of CLL patients at Hospital Clinic of Barcelona. keywords: cll; covid-19; ibrutinib; patients cache: cord-255037-i9guxtix.txt plain text: cord-255037-i9guxtix.txt item: #703 of 2876 id: cord-255197-79yfslu1 author: Soo, Chun Ian title: Telehealth: “virtual” lifeline for home-ventilated patients during the COVID-19 pandemic date: 2020-09-28 words: 1155 flesch: 30 summary: Crucial interventions for HMV patients such as polysomnography, ventilator titration, speech therapy, dietary consultation and rehabilitation interventions were forced to cease due to logistic or infection control considerations. Many mobile applications for telehealth also have an enormous impact on the management of HMV patients. keywords: hmv; home; patients; telehealth cache: cord-255197-79yfslu1.txt plain text: cord-255197-79yfslu1.txt item: #704 of 2876 id: cord-255233-rvgj6pvk author: Munday, Molly-Rose title: A Pilot Study Examining Vitamin C Levels in Periodontal Patients date: 2020-07-28 words: 3897 flesch: 48 summary: Although a small study, this rate of vitamin C deficiency in the periodontal clinic is clinically important and correlations with disease severity and CRP suggests biological importance. Vitamin C deficiency is more common in smokers, the elderly and people of lower socio-economic status, potentially putting those groups at increased risk of periodontal diseases [24, 25] . keywords: crp; deficiency; disease; levels; patients; people; study; vitamin cache: cord-255233-rvgj6pvk.txt plain text: cord-255233-rvgj6pvk.txt item: #705 of 2876 id: cord-255240-ltatgq3e author: Kesserwani, Hassan title: Cerebral Microbleeds - To Treat or Not to Treat, That Is the Question: A Case Report With a Note on Its Radiologic Deconstruction and Therapeutic Nuances date: 2020-09-20 words: 3421 flesch: 49 summary: There is also evidence that lobar CMBs may be more common than deep CMBs in patients with atrial fibrillation [19] . We present this case in order to highlight the dilemma of anti-platelet therapy in this group of patients and we demonstrate the cardinal radiologic features of CMBs. keywords: anti; cmbs; disease; microbleeds; patients; risk; stroke; therapy; year cache: cord-255240-ltatgq3e.txt plain text: cord-255240-ltatgq3e.txt item: #706 of 2876 id: cord-255256-8uckmya4 author: None title: Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date: 2020-08-18 words: 3536 flesch: 45 summary: Methods: This retrospective study evaluated intensive care unit patients who underwent CVVH with RCA between 2016 and 2017. Severity of AKI was categorized according to KDIGO Methods: This retrospective study evaluated intensive care unit patients who underwent CVVH with RCA between 2016 and 2017. keywords: blood; cvvh; der; die; icu; mean; patients; study; therapy; und cache: cord-255256-8uckmya4.txt plain text: cord-255256-8uckmya4.txt item: #707 of 2876 id: cord-255267-o8k5ep9y author: Gan, Connie Cai Ru title: Personal ventilation hood for protecting healthcare workers from aerosol-transmissible diseases date: 2020-07-22 words: 354 flesch: 33 summary: Even in situations where a patient needs to be moved to another facility, the hood could limit the exposure to other patients and hospital personnel. key: cord-255267-o8k5ep9y authors: Gan, Connie Cai Ru; Tseng, Yu-Chi; Lee, Feng-You; Lee, Kuan-I title: Personal ventilation hood for protecting healthcare workers from aerosol-transmissible diseases date: 2020-07-22 journal: Am J Emerg Med DOI: 10.1016/j.ajem.2020.07.036 sha: doc_id: 255267 cord_uid: o8k5ep9y nan The provisional pilot study shows, the hood offers several potential implications. keywords: healthcare; hood cache: cord-255267-o8k5ep9y.txt plain text: cord-255267-o8k5ep9y.txt item: #708 of 2876 id: cord-255300-btyth32l author: Kang, Swan title: Oculoplastic video-based telemedicine consultations: Covid-19 and beyond date: 2020-05-12 words: 1178 flesch: 37 summary: Most devices used for video consultations would provide sufficient resolution for the objective assessment of oculoplastic parameters [3] [4] [5] [6] and those examinations that cannot be conducted effectively (for example, visual acuity or optic nerve function testing) have often been conducted already by the referrer or during a previous examination. In response to the Covid-19 pandemic, our institution has rapidly deployed video consultations using Attend Anywhere, a browser-based platform that allows clinicians to work through a list of patients in a virtual waiting room. keywords: consultation; patients; telemedicine; video cache: cord-255300-btyth32l.txt plain text: cord-255300-btyth32l.txt item: #709 of 2876 id: cord-255393-aknebauo author: Piccoli, Giorgina Barbara title: Setting the clock back: new hope for dialysis patients. Sodium thiosulphate and the regression of vascular calcifications date: 2020-05-16 words: 1215 flesch: 37 summary: key: cord-255393-aknebauo authors: Piccoli, Giorgina Barbara; Torreggiani, Massimo; Gendrot, Lurlynis; Nielsen, Louise title: Setting the clock back: new hope for dialysis patients. One of them deserves particular attention, as it brings new hope for dialysis patients. keywords: dialysis; patients; sodium cache: cord-255393-aknebauo.txt plain text: cord-255393-aknebauo.txt item: #710 of 2876 id: cord-255435-mr239gai author: Sher, Yelizaveta title: A CASE REPORT OF COVID-19 ASSOCIATED HYPERACTIVE ICU DELIRIUM WITH PROPOSED PATHOPHYSIOLOGY AND TREATMENT date: 2020-05-19 words: 3529 flesch: 31 summary: While no studies have demonstrated pharmacological efficacy in the management of delirium among COVID-19 patients, we provide a framework for choosing psychotropic medications to assist in achieving behavioral control in ICU patients. Delirium, which is highly prevalent in general intensive care unit (ICU) populations, is expected to be frequent and prominent in COVID-19 patients hospitalized with acute respiratory distress syndrome (ARDS) in ICU. keywords: case; covid-19; day; delirium; icu; management; patients; treatment cache: cord-255435-mr239gai.txt plain text: cord-255435-mr239gai.txt item: #711 of 2876 id: cord-255460-r5p5helx author: Aggarwal, Sadhna title: Drug repurposing for breast cancer therapy: Old weapon for new battle date: 2019-09-21 words: 7359 flesch: 38 summary: The widely used SERMs that have been repositioned as breast cancer drugs are tamoxifen (1977), toremifene (1997) and raloxifene (2007) . Drug companies that expand the repositioning in similar therapeutic areas, such as reusing ovarian cancer drug as breast cancer drug, had success rate of 67% in comparison to 33% success rate when explored in different area keywords: breast; breast cancer; cancer; combination; development; drug; effects; hormone; new; patients; phase; receptor; repositioning; repurposing; therapy; treatment; trial; women cache: cord-255460-r5p5helx.txt plain text: cord-255460-r5p5helx.txt item: #712 of 2876 id: cord-255490-gyq6cpc9 author: Wang, Chang‐Zheng title: Early risk factors of the exacerbation of Coronavirus disease 2019 pneumonia date: 2020-05-29 words: 2325 flesch: 48 summary: Severe patients often develop dyspnea and/or hypoxemia one week after onset, and may even rapidly progress to acute respiratory distress syndrome (ARDS), septic shock, hard-to-correct metabolic acidosis, bleeding and coagulation dysfunction, and multiple organ failure 2 . Early identification of patients with possible deterioration of the disease is particularly important for controlling the proportion of severe patients and reduce the mortality. keywords: coronavirus; count; covid-19; disease; patients cache: cord-255490-gyq6cpc9.txt plain text: cord-255490-gyq6cpc9.txt item: #713 of 2876 id: cord-255519-tcobane8 author: Bartels, Matthew N. title: Acute Medical Conditions: Cardiopulmonary Disease, Medical Frailty, and Renal Failure date: 2020-10-02 words: 20003 flesch: 28 summary: Guidelines for cardiac rehabilitation and secondary prevention programs Core components of cardiac rehabilitation/secondary prevention programs: a statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit Acute medical rehabilitation Physical medicine and rehabilitation patient centered care Essential physical medicine and rehabilitation Evaluation of pulmonary function and exercise performance by cardiopulmonary exercise testing before and after lung transplantation Improving the quality of quality improvement projects Canadian Study of Health and Aging Working Group: Disability and frailty among elderly Canadians: a comparison of six surveys Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women Core competencies for cardiac rehabilitation/secondary prevention professionals: 2010 update: position statement of the American Association of Cardiovascular and Pulmonary Rehabilitation Physical activity and public health: updated recommendation for adults from the Objectively measured sedentary time may predict insulin resistance independent of moderate-and vigorous-intensity physical activity The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians The effects of training on heart rate; a longitudinal study Medical director responsibilities for outpatient cardiac rehabilitation/secondary prevention programs: 2012 update: a statement for health care professionals from the American Association for Cardiovascular and Pulmonary Rehabilitation and the American Heart Association Rehabilitation for hospital-associated deconditioning The long-term psychological effects of daily sedative interruption on critically ill patients Exercise testing in asymptomatic adults: a statement for professionals from the American Heart Association Council on Clinical Cardiology, Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American Association of Cardiovascular and Pulmonary Rehabilitation IGF-1, the cross road of the nutritional, inflammatory and hormonal pathways to frailty Uremic myopathy limits aerobic capacity in hemodialysis patients Coronary heart-disease and physical activity of work Coronary heart-disease and physical activity of work Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference European Respiratory Society statement on pulmonary rehabilitation Clinical competency guidelines for pulmonary rehabilitation professionals: American Association of Cardiovascular and Pulmonary Rehabilitation Position Statement Cardiac rehabilitation after myocardial infarction. Diagnostic and statistical manual of mental disorders The national medical series for independent study: anatomy Culture of early mobility in mechanically ventilated patients Core components of cardiac rehabilitation/secondary prevention programs: a statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle Physical activity and mortality related to obesity and functional status in older adults in Spain Developing a rural transitional care community case management program using clinical nurse specialists Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit Acute medical rehabilitation Grabois M, editor: Physical medicine and rehabilitation: the complete approach Physical medicine and rehabilitation patient centered care Pulmonary rehabilitation Rehabilitation management of lung volume reduction surgery Evaluation of pulmonary function and exercise performance by cardiopulmonary exercise testing before and after lung transplantation Improving the quality of quality improvement projects Lower limb skeletal muscle function after 6 wk of bed rest Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study Bed rest in heart trouble Effectiveness and safety of a home-based cardiac rehabilitation programme of mixed surveillance in patients with ischemic heart disease at moderate cardiovascular risk: a randomised, controlled clinical trial A perfect storm: care transitions for vulnerable older adults discharged home from the emergency department without a hospital admission Canadian Study of Health and Aging Working Group: Disability and frailty among elderly Canadians: a comparison of six surveys Electrophysiologic studies in the denervated transplanted human heart. keywords: activity; american; association; cardiac; cardiopulmonary; care; chronic; clinical; disease; exercise; failure; following; frailty; health; heart; heart disease; intensity; lung; mobilization; patients; physical; prevention; program; pulmonary; rate; rehabilitation; risk; syndrome; training; transplantation cache: cord-255519-tcobane8.txt plain text: cord-255519-tcobane8.txt item: #714 of 2876 id: cord-255652-3n2dxljj author: Challener, Douglas W. title: Screening for COVID-19: Patient factors predicting positive PCR test date: 2020-05-19 words: 1164 flesch: 46 summary: Patients with positive tests were significantly more likely to have travelled to a major metropolitan area within the preceding 2 weeks or to have come into contact with a person with laboratory-confirmed COVID-19. Recent travel and exposure to a confirmed case were both highly predictive of positive testing. keywords: covid-19; patients; screening; testing cache: cord-255652-3n2dxljj.txt plain text: cord-255652-3n2dxljj.txt item: #715 of 2876 id: cord-255746-ir73lpi8 author: Sirimaturos, Michael title: Clinical Outcomes Following Tocilizumab Administration in Mechanically Ventilated Coronavirus Disease 2019 Patients date: 2020-10-01 words: 4106 flesch: 32 summary: While several reports on tocilizumab treatment in COVID-19 patients now exist, data pertaining specifically to tocilizumab use in a large cohort of critically ill patients on invasive ventilation is lacking (11, 12) . This retrospective review of COVID-19 patients managed within the Houston Methodist Hospital System from March 24, 2020, to May 4, 2020, used data from electronic medical records and the institution's clinical surveillance program. keywords: administration; covid-19; days; disease; improvement; mortality; patients; tocilizumab; treatment cache: cord-255746-ir73lpi8.txt plain text: cord-255746-ir73lpi8.txt item: #716 of 2876 id: cord-255805-wlr8nod3 author: Liu, Yan title: Experience of N-acetylcysteine airway management in the successful treatment of one case of critical condition with COVID-19: A case report date: 2020-10-16 words: 3833 flesch: 36 summary: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Transmission of nCoV infection from an asymptomatic contact in Germany int-Coronavirus disease COVID-19 advice for the public Myth busters Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China Clinical characteristics of 2019 novel coronavirus infection in China Clinical and biochemical indexes from nCoV infected patients linked to viral loads and lung injury Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP) Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer Pathological findings of COVID-19 associated with acute respiratory distress syndrome Gross examination report of a COVID-19 death autopsy The effect of an oral anti-oxidant, N-Acetyl-cysteine, on inflammatory and oxidative markers in pulmonary sarcoidosis Associations of pulmonary fibrosis with peripheral blood Th1/Th2 cell imbalance and EBF3 gene methylation in uygur pigeon breeder's lung patients Multifaceted activity of Nacetyl-l-cysteine in chronic obstructive pulmonary disease Patients with critically COVID-19 usually require invasive respiratory support, and the airway management is particularly important and the prognosis is poor. keywords: airway; blood; chest; coronavirus; novel; patient; pneumonia; treatment; ventilation cache: cord-255805-wlr8nod3.txt plain text: cord-255805-wlr8nod3.txt item: #717 of 2876 id: cord-255807-7goz1agp author: Hak, E. title: Conventional Influenza Vaccination Is Not Associated with Complications in Working-Age Patients with Asthma or Chronic Obstructive Pulmonary Disease date: 2003-04-15 words: 4315 flesch: 32 summary: Because influenza vaccination appeared not to be associated with a clinically relevant reduction in severe morbidity, other measures need to be explored. Although the vaccine does not lead to potentially adverse effects in asthmatics (12) , the few available small-scale studies on the clinical benefits of influenza vaccination among working-age patients with COPD have failed to demonstrate any effectiveness from annual vaccination (6, 13, 14) . keywords: age; asthma; copd; influenza; patients; season; study; vaccination; vaccine cache: cord-255807-7goz1agp.txt plain text: cord-255807-7goz1agp.txt item: #718 of 2876 id: cord-255831-nrc35tug author: Alviggi, Carlo title: COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management date: 2020-05-13 words: 4472 flesch: 42 summary: Based on female age, ovarian reserve, and previous history of ovarian stimulation -if available-, 'low prognosis' patients were stratified into four specific subgroups, each of which with a distinct prognosis concerning the likelihood of conceiving and delivering a baby with the use of ART (Supplementary Figure 3) . 'low prognosis' patients (e.g., Poseidon groups 2, 3, and 4): i. Poseidon group patients 2 could undergo ovarian stimulation and IVF for oocyte freezing or embryo freezing, as appropriate, as the ovarian reserve is still fair keywords: art; covid-19; embryo; fertility; group; oocytes; ovarian; patients; poseidon; treatment; women cache: cord-255831-nrc35tug.txt plain text: cord-255831-nrc35tug.txt item: #719 of 2876 id: cord-255905-ti9b1etu author: Qiu, Chengfeng title: Transmission and clinical characteristics of coronavirus disease 2019 in 104 outside-Wuhan patients, China date: 2020-03-06 words: 3779 flesch: 56 summary: With the increased awareness of early discovery and timely treatment, organ function damage was occurred just in few patients, that is quite different from observation of patients in Wuhan patients. For the study population, imported case was defined as an infector who emigrated from Wuhan (who ever lived in or traveled to Wuhan), the rest of study patients were defined as indigenous cases. keywords: holder; license; medrxiv; patients; peer; perpetuity; preprint cache: cord-255905-ti9b1etu.txt plain text: cord-255905-ti9b1etu.txt item: #720 of 2876 id: cord-256011-0cr4ejxu author: de Castro-Hamoy, Leniza title: Age Matters but it should not be Used to Discriminate Against the Elderly in Allocating Scarce Resources in the Context of COVID-19 date: 2020-06-16 words: 4413 flesch: 46 summary: Elderly COVID-19 patients are among those who are worst off because they appear to be the most likely to succumb to the disease. Human beings-rather than human life years-are asking to be saved. keywords: age; allocation; care; covid-19; life; number; patient cache: cord-256011-0cr4ejxu.txt plain text: cord-256011-0cr4ejxu.txt item: #721 of 2876 id: cord-256030-5xzuilc1 author: Michel, Pierre-Antoine title: Home hemodialysis during the COVID-19 epidemic: comment on the French experience from the viewpoint of a French home hemodialysis care network date: 2020-11-11 words: 1750 flesch: 41 summary: Furthermore, while home dialysis encompasses 7% of all French dialysis patients, data from the French Biomedicine Agency show that the proportion of home dialysis patients (whether on hemodialysis or on peritoneal dialysis) represented 2.6% of the total number of dialysis patients diagnosed with COVID-19 during the period March-October 2020 [9] . 2020) in the name of the French REIN registry Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients Exposure to novel coronavirus in patients on renal replacement therapy during the exponential phase of COVID-19 pandemic: survey of the Italian Society of Nephrology Minimizing the risk of COVID-19 among patients on dialysis Time to expand access and utilization of home dialysis: lessons from the COVID-19 pandemic Situation de l'épidémie de Covid-19 chez les patients dialysés et greffés rénaux en France Situation of the Covid-19 epidemic in patients on peritoneal dialysis on 2020/05/15 in France: RDPLF data-base Home haemodialysis: how it began, where it went wrong, and what it may yet be Home dialysis as a first option: a new paradigm We would like to thank all the dialysis centers participating in the RDPLF and the REIN registries which, despite this difficult period, with a significant work overload, actively collected data and were available for additional information. keywords: covid-19; hemodialysis; home; patients cache: cord-256030-5xzuilc1.txt plain text: cord-256030-5xzuilc1.txt item: #722 of 2876 id: cord-256051-87alqfkd author: Revzin, Margarita V. title: Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications date: 2020-10-01 words: 8866 flesch: 29 summary: The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis Thromboinflammation and the hypercoagulability of COVID-19 Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic Indirect CT Venography at 80 kVp with Sinogram-Affirmed Iterative Reconstruction Compared to 120 kVp with Filtered Back Projection: Assessment of Image Quality and Radiation Dose Combined Direct and Indirect CT Venography (Combined CTV) in Detecting Lower Extremity Deep Vein Thrombosis Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Incidence of venous thromboembolism in hospitalized patients with COVID-19 D-dimer is Associated with Severity of Coronavirus Disease 2019: Chest radiography is a less sensitive modality for the detection of COVID-19 lung disease when compared with that CT, with a reported baseline chest radiography sensitivity of 69% (64). keywords: ards; cases; chest; complications; coronavirus; cov-2; covid-19; disease; fig; findings; imaging; infection; lung; patients; pneumonia; sars cache: cord-256051-87alqfkd.txt plain text: cord-256051-87alqfkd.txt item: #723 of 2876 id: cord-256109-dkp0fwe3 author: Mazzulli, Tony title: Severe Acute Respiratory Syndrome–associated Coronavirus in Lung Tissue date: 2004-01-17 words: 2564 flesch: 47 summary: The clinical description and RT-PCR results for the 11 patients with probable SARS from whom postmortem lung tissue samples were examined are summarized in Table 1 . By contrast, the sensitivity and specificity of the RealArt HPA-Coronavirus RT-PCR assay for detecting CoV in lung tissue samples appear to be excellent. keywords: cov; lung; patients; respiratory; samples; sars; tissue cache: cord-256109-dkp0fwe3.txt plain text: cord-256109-dkp0fwe3.txt item: #724 of 2876 id: cord-256117-t9v1hng5 author: Al Kasab, Sami title: Acute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic: From Trough of Disillusionment to Slope of Enlightenment date: 2020-06-03 words: 1600 flesch: 49 summary: 3 Given that approximately 35% of patients with COVID-19 are asymptomatic and the growing awareness that asymptomatic patients are able to transmit the virus, this screening might not be sufficient. Patients ruled out for LVO can remain at the spoke for routine care, even those who receive intravenous thrombolysis, particularly those spokes that are primary stroke center certified. keywords: care; covid-19; patients; room cache: cord-256117-t9v1hng5.txt plain text: cord-256117-t9v1hng5.txt item: #725 of 2876 id: cord-256262-lwc4ghj2 author: Gangneux, Jean-Pierre title: Invasive fungal diseases during COVID-19: We should be prepared date: 2020-04-06 words: 1144 flesch: 24 summary: -To improve the diagnosis, in proposing an efficient syndromic molecular approach for fungal respiratory infection during ARDS that can be shared with all hospitals receiving COVID-19 patients -To Among various causes of morbidity and mortality in COVID-19 patients, the frequency and impact of co-infections has still been poorly studied, particularly in patients with an acute respiratory distress syndrome (ARDS). keywords: covid-19; infection; mortality; patients cache: cord-256262-lwc4ghj2.txt plain text: cord-256262-lwc4ghj2.txt item: #726 of 2876 id: cord-256290-pyrmtps3 author: Kerr, Colm title: Prevalence of smell and taste dysfunction in a cohort of CoVID19 outpatients managed through remote consultation from a large urban teaching hospital in Dublin, Ireland date: 2020-07-15 words: 1349 flesch: 49 summary: To our knowledge, this is the first reported taste and smell disturbance data in CoVID19 patients from the Irish healthcare system. [5] They have recommended that clinicians assess olfactory sensation in patients with suspected CoVID19 to further establish this link. keywords: covid19; patients; smell; taste cache: cord-256290-pyrmtps3.txt plain text: cord-256290-pyrmtps3.txt item: #727 of 2876 id: cord-256459-6h358si5 author: Sharpstone, D title: Gastrointestinal manifestations of HIV infection date: 1996-08-10 words: 3646 flesch: 29 summary: 6 In the last review some of the included trials were Acute HIV infection presenting with painful swallowing and esophageal ulcers Natural history and prognosis of diarrhoea of unknown cause in patients with acquired immunodeficiency syndrome (AIDS) Effects of zidovudine treatment on the small intestinal mucosa in patients infected with the human immunodeficiency virus Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine Intestinal mucosal inflammation associated with human immunodeficiency virus infection Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms Duodenal mucosal T cell subpopulation and bacterial cultures in acquired immunodeficiency syndrome Association of gastric hypoacidity with opportunistic enteric infections in patients with AIDS Decreased gastric acid secretion and bacterial colonisation of the stomach in severely malnourished Bangladeshi children Prevalance of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome Infectious diarrhea in patients with AIDS Gastrointestinal symptoms in patients infected with human immunodeficiency virus: relevance of infective agents isolated from gastrointestinal tract Prevalence of intestinal protozoans in French patients infected with AIDS Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation Faecal tumour necrosis factor-alpha in HIV-related diarrhoea The diagnosis of AIDS-related chronic diarrhoea: a prospective study in 155 patients Light and electron microscopic appearances of pathological changes in HIV gut infection Enterotoxic effect of stool supernatant of Cryptosporidium-infected calves on human jejunum Jejunal water and electrolyte transport in AIDS-related cryptosporidiosis Small bowel transit in HIVseropositive individuals Autonomic denervation in jejunal mucosa of homosexual men infected with HIV Loss of mucosal CD4 lymphocytes is an early feature of HIV infection Mechanisms of innate and acquired resistance to Cryptosporidium parvum infection in SCID mice Cryptosporidium infection in an adult mouse model: independent roles for IFN-â�¥ and CD4+ T lymphocytes in protective immunity Faecal tumour necrosis factor-alpha and faecal alpha-one-antitrypsin in HIV infection Diarrhoea in HIV-infected patients: no evidence of cytokine-mediated inflammation in jejunal mucosa An algorithm for the investigation of diarrhoea in HIV infection Use of the fluorochrome Calcofluor white in the screening of stool specimens for spores of microsporidia Salmonella, campylobacter and shigella in HIV positive patients Gastrointestinal viral infections in homosexual men who were symptomatic and seropositive for human immunodeficiency virus Efficient management of diarrhea in the acquired immunodeficiency syndrome (AIDS): a medical decision analysis Cytomegalovirus in AIDS: presentation in 44 patients and a review of the literature Spectral and sequence similarity between vasoactive intestinal peptide and the second conserved region of human immunodeficiency virus type 1 envelope glycoprotein (gp 120): possible consequences on prevention and therapy of AIDS Elevated plasma levels of vasoactive intestinal peptide in AIDS patients with refractory idiopathic diarrhea: effects of treatment with octreotide Octreotide therapy of large volume refractory AIDS-associated diarrhea: a randomized controlled trial Treatment with albendazole for intestinal disease due to Enterocytozoon bieneusi in patients with AIDS Thalidomide for microsporidiosis Atrovaquone is effective treatment for the symptoms of gastrointestinal microsporidiosis in HIV-1 infected patients Paromomycin for cryptosporidiosis in AIDS: a Health Information Research Unit Intestinal function and injury acquired immunodeficiency syndrome-related cryptosporidiosis Infective dose size studies on Cryptosporidium parvum using gnotobiotic lambs However, there is a consistent increase in small-bowel permeability in HIV-seropositive individuals; 5 this functional abnormality and the minor structural abnormalities of the small bowel mucosa may be due to the immunological changes produced by HIV infection of lamina propria lymphocytes. keywords: adherence; aids; diarrhoea; hiv; immunodeficiency; individuals; infection; patients; treatment cache: cord-256459-6h358si5.txt plain text: cord-256459-6h358si5.txt item: #728 of 2876 id: cord-256508-ce59ovan author: Asselah, Tarik title: COVID-19: discovery, diagnostics and drug development date: 2020-10-08 words: 9235 flesch: 42 summary: If RT-qPCR-based molecular assays for detecting SARS CoV-2 in respiratory specimens remain the current reference standard for diagnosis, point-of care technologies, and serologic immunoassays have also rapidly emerged [57] Indeed, antibodies to this protein are frequently detected in COVID-19 patient [64] keywords: antibodies; cell; coronavirus; cov-2; covid-19; disease; drug; human; immune; infection; liver; patients; remdesivir; samples; sars; study; testing; tests; treatment; virus cache: cord-256508-ce59ovan.txt plain text: cord-256508-ce59ovan.txt item: #729 of 2876 id: cord-256535-fz5p2u6p author: Oki, Sogo title: Long-Term Clinical Outcome and Prognosis After Thrombectomy in Patients With Concomitant Malignancy date: 2020-10-15 words: 3379 flesch: 42 summary: Cerebrovascular complications in patients with cancer Association between incident cancer and subsequent stroke Poor short-term outcome in patients with ischaemic stroke and active cancer Ischemic stroke in cancer patients with and without conventional mechanisms: a multicenter study in Korea Stroke and cancer: the importance of cancer-associated hypercoagulation as a possible stroke etiology A randomized trial of intraarterial treatment for acute ischemic stroke Endovascular therapy for ischemic stroke with perfusion-imaging selection Randomized assessment of rapid endovascular treatment of ischemic stroke Thrombectomy within 8 hours after symptom onset in ischemic stroke Stentretriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial Successful treatment of repeated bilateral middle cerebral artery occlusion by performing mechanical thrombectomy in a patient Histological examination of trousseau syndrome-related thrombus retrieved through acute endovascular thrombectomy: report of 2 cases Mechanical thrombectomy for trousseau syndrome in a terminally ill cancer patient Efficacy of 'drive and retrieve' as a cooperative method for prompt endovascular treatment for acute ischemic stroke Lowmolecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer Spontaneous echo contrast and thrombus formation at the carotid bifurcation after carotid endarterectomy The validity of the Acute Stroke Assessment using rapid Pseudo-continuous arterial spin labeling (ASAP-ASL) method for acute thrombectomy Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement Procedural and clinical outcomes of endovascular recanalization therapy in patients with cancer-related stroke Safety and efficacy of reperfusion therapies for acute ischemic stroke patients with active malignancy Intra-arterial thrombectomy for acute ischaemic stroke patients with active cancer Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update International clinical practice guidelines including guidance for direct oral anticoagulants in the treatment and prophylaxis of venous thromboembolism in patients with cancer Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report Stroke in cancer patients Antithrombotic therapy strategy for cancer-associated ischemic stroke: a case series of 26 patients FTY720 (Fingolimod) ameliorates brain injury through multiple mechanisms and is a strong candidate for stroke treatment FTY720 protects against ischemia-reperfusion injury by preventing the redistribution of tight junction proteins and decreases inflammation in the subacute phase in an experimental stroke model Treatment of acute ischemic stroke due to large vessel occlusion with COVID-19: experience from Paris Short-term results of EVT in concomitant cancer patients seem favorable (12) (13) (14) . keywords: cancer; evt; ischemic; malignancy; patients; stroke; term; treatment cache: cord-256535-fz5p2u6p.txt plain text: cord-256535-fz5p2u6p.txt item: #730 of 2876 id: cord-256556-1zea3wa1 author: Lou, Yan title: Clinical Outcomes and Plasma Concentrations of Baloxavir Marboxil and Favipiravir in COVID-19 Patients: An Exploratory Randomized, Controlled Trial date: 2020-10-25 words: 4234 flesch: 43 summary: To determine whether the apparent lack of benefits by the addition of either baloxavir marboxil or favipiravir is related to their pharmacological exposure in the COVID-19 patients, drug concentrations were measured in the patients. This study aims to evaluate the clinical outcomes and plasma concentrations of baloxavir acid and favipiravir in COVID-19 patients. keywords: baloxavir; concentrations; covid-19; favipiravir; group; marboxil; patients; treatment; trial cache: cord-256556-1zea3wa1.txt plain text: cord-256556-1zea3wa1.txt item: #731 of 2876 id: cord-256618-tt3p0tki author: Liao, Yun title: Role of pharmacists during the COVID‐19 pandemic in China ‐ Shanghai Experiences date: 2020-06-14 words: 2485 flesch: 42 summary: Pharmacists also participate in evaluating new treatments and keeping health care teams informed of new findings for potential treatment considerations. Community pharmacies serve as the public access point to health care and medical supplies, providing services beyond dispensing and medication counselling. keywords: care; covid-19; health; patients; pharmacists; rights; shanghai cache: cord-256618-tt3p0tki.txt plain text: cord-256618-tt3p0tki.txt item: #732 of 2876 id: cord-256634-gg8hptfg author: Rhodes, N. J. title: Multicenter point-prevalence evaluation of the utilization and safety of drug therapies for COVID-19 date: 2020-06-06 words: 4112 flesch: 46 summary: Patients were identified at each site according to institutional guidelines for identification and monitoring of COVID-19 patients. Adverse drug reactions were defined based upon existing knowledge of the side effect profiles of the agents evaluated as well as the existing literature on adverse events observed in COVID-19 patients at the time of the study. keywords: covid-19; drug; medrxiv; patients; preprint; remdesivir; therapies; therapy cache: cord-256634-gg8hptfg.txt plain text: cord-256634-gg8hptfg.txt item: #733 of 2876 id: cord-256639-4e0irb6d author: Jean-Michel, Vanessa title: Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation date: 2020-09-06 words: 842 flesch: 43 summary: Thiopental seems to be an acceptable substitute to sedative drugs in this period of high midazolam and propofol demand for ICU patients with COVID-19. Dexmedetomedine was used in the two groups of patients during withdrawal of sedative drugs to prevent occurrence of delirium as recommended by a recent guideline [6] . keywords: covid-19; patients; thiopental cache: cord-256639-4e0irb6d.txt plain text: cord-256639-4e0irb6d.txt item: #734 of 2876 id: cord-256688-yy7abob9 author: Chavez, Summer title: Coronavirus Disease (COVID-19): A primer for emergency physicians date: 2020-03-24 words: 6440 flesch: 47 summary: COVID-19 pushing Italian ICUs toward collapse Novel Coronavirus (2019-nCoV) flowchart for healthcare professionals A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Clinical characteristics of Coronavirus Disease 2019 in China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected COVID-19) Interim Infection Prevention and Control Recommendations Novel Coronavirus (2019-nCoV) healthcare infection prevention and control FAQs for COVID-19 COVID-19: what is next for public health? COVID-19): evaluating and testing persons for Coronavirus Disease 2019 (COVID-19) Novel Coronavirus (2019-nCoV) evaluating and reporting PUI COVID-19) Interim Guidance for Emergency Medical Services (EMS) Systems and 911 Public Safety Answering Points (PSAPs) for COVID-19 in the United States Novel Coronavirus (2019-nCoV) infection control Surviving sepsis campaign: guidelines on the management of critically ill adults with Coronavirus Disease Infection prevention and control for coronavirus disease (COVID-19): interim guidance for acute healthcare settings Anesthesia Patient Safety Foundation Novel Coronavirus (2019-nCoV) Testing Novel Coronavirus (2019-nCoV) information for laboratories COVID-19 requests for diagnostic panels and virus COVID-19) interim guidelines for collecting, handling, and testing clinical specimens from persons under investigation (PUIs) for Coronavirus Disease 2019 (COVID-19) Detection of SARS-CoV-2 in different types of clinical specimens Correlation of chest CT and RT-PCR testing in Coronavirus Disease 2019 (COVID-19) in China: a report of 1014 cases. Up to 94% of COVID-19 cases were reported to originate from Hubei Province in December 2019; as of March 2020, the greatest number of new cases are now being reported in Italy, Spain, Germany, and the United States (U.S.) (Figs. 3 and 4) keywords: cases; coronavirus; covid-19; disease; emergency; health; infection; ncov; novel; patients; pneumonia; risk; sars; study; symptoms cache: cord-256688-yy7abob9.txt plain text: cord-256688-yy7abob9.txt item: #735 of 2876 id: cord-256849-8w2avwo2 author: Koenig, Kristi L. title: Identify-Isolate-Inform: A Tool for Initial Detection and Management of Measles Patients in the Emergency Department date: 2015-03-18 words: 2865 flesch: 47 summary: The “Identify-Isolate-Inform” tool will assist emergency physicians to be better prepared to detect and manage measles patients presenting to the emergency department. Following a brief review of measles, this paper describes the novel 3I tool, initially developed for Ebola virus disease, 4 as adapted for use in the initial detection and management of measles patients in the emergency department (ED). keywords: children; days; disease; measles; patients; rash cache: cord-256849-8w2avwo2.txt plain text: cord-256849-8w2avwo2.txt item: #736 of 2876 id: cord-256856-jw1d6uig author: Sohinki, Daniel title: What Coronavirus Disease 2019 Has Taught Us About Modern Electrophysiology Practice date: 2020-08-15 words: 2072 flesch: 35 summary: Physicians and hospitals worldwide are facing unprecedented challenges, struggling to find a balance between appropriate care delivery, patient and staff safety, and dire economic conditions that threaten the livelihoods not only of patients but also of health care providers and the entire health system. Patients could be referred for laboratory or imaging testing that could be completed locally, which is particularly advantageous for patients who live long distances from their specialist. keywords: care; patient; physician; telehealth; telemedicine cache: cord-256856-jw1d6uig.txt plain text: cord-256856-jw1d6uig.txt item: #737 of 2876 id: cord-256864-v3mxcwru author: Tang, Yueting title: Selection of an Optimal Combination Panel to Better Triage COVID-19 Hospitalized Patients date: 2020-10-27 words: 5127 flesch: 39 summary: The rate of admission to ICU was 18.75% vs.14.29%; while discharge rate was 15.63% vs 50.0%, for the critical vs severe patients, respectively. Panel three (WBC, PCT, IL-6, IL-10, and SOD) had much better performance in the initial triage model in risk prediction for the critical vs severe patients. keywords: biomarkers; covid-19; disease; group; il-10; il-6; infection; panel; patients; pct; risk; serum; sod cache: cord-256864-v3mxcwru.txt plain text: cord-256864-v3mxcwru.txt item: #738 of 2876 id: cord-256888-tdx12ccj author: Bradley, Benjamin T title: Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series date: 2020-07-16 words: 5010 flesch: 42 summary: Patient 3 and patient 9 also had microthrombi in the trachea, although in patient 3 this was qualified by chronic tracheostomy. We hypothesise that there was a subclinical period during which lung injury was occurring in COVID-19 patients with organising diffuse alveolar disease who died in the week after symptom onset. keywords: cov-2; covid-19; diffuse; disease; findings; infection; injury; lung; particles; patients; sars cache: cord-256888-tdx12ccj.txt plain text: cord-256888-tdx12ccj.txt item: #739 of 2876 id: cord-256893-3sh87h2x author: Yang, Li title: COVID-19: immunopathogenesis and Immunotherapeutics date: 2020-07-25 words: 5360 flesch: 33 summary: A Novel Coronavirus from patients with Pneumonia in China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-infected Pneumonia in Wuhan, China Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome Different features of Vdelta2 T and NK cells in fatal and non-fatal human Ebola infections Immune parameters and outcomes during Ebola virus disease Clinical features and progression of acute respiratory distress syndrome in coronavirus disease 2019 Laboratory abnormalities in patients with COVID-2019 infection Pathological findings of COVID-19 associated with acute respiratory distress syndrome Dysregulation of immune response in patients with COVID-19 in Wuhan, China Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients SARS-CoV-2 infection in children Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city Clinical characteristics of imported cases of COVID-19 in Jiangsu province: a multicenter descriptive Study Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series A new coronavirus associated with human respiratory disease in China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Clinical characteristics of Coronavirus disease 2019 in China Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP) Reduction and functional exhaustion of T cells in patients with Coronavirus Disease 2019 (COVID-19) Immune characteristics predict outcome of severe and critical COVID-19 patients Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals T cell responses to whole SARS coronavirus in humans Aberrant pathogenic GM-CSF+T cells and inflammatory CD14 +CD16+monocytes in severe pulmonary syndrome patients of a new coronavirus The significance of OX40 and OX40L to Tcell biology and immune disease 4-1BB co-stimulation enhances human CD8(+) T cell priming by augmenting the proliferation and survival of effector CD8(+) T cells Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 Restoration of leukomonocyte counts is associated with viral clearance in COVID-19 hospitalized patients Functional exhaustion of antiviral lymphocytes in COVID-19 patients Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19 Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 Antibody responses to SARS-CoV-2 in patients with COVID-19 Assessment of SARS-CoV-2 serological tests for the diagnosis of COVID-19 through the evaluation of three immunoassays: two automated immunoassays (Euroimmun and Abbott) and one rapid lateral flow immunoassay (NG Biotech) Immunopathogenesis of coronavirus infections: implications for SARS Fighting COVID-19 exhausts T cells COVID-19: immunopathology and its implications for therapy Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice The interplay between neutrophils and microbiota in cancer COVID-19: immunopathogenesis and Immunotherapeutics Yang Management of cytokine release syndrome related to CAR-T cell therapy Cytokine release syndrome Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing TH17 responses in cytokine storm of COVID-19: an emerging target of JAK2 inhibitor Fedratinib Expression of B and T lymphocyte attenuator (BTLA) in macrophages contributes to the fulminant hepatitis caused by murine hepatitis virus strain-3 VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism Antibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS Signals of T h 2 immune response from COVID-19 patients requiring intensive care Antibody-dependent enhancement of severe dengue disease in humans The microbiome and innate immunity IL-1beta is a key cytokine that induces trypsin upregulation in the influenza virus-cytokine-trypsin cycle A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic. keywords: cases; cell; clinical; coronavirus; cov-2; covid-19; cytokine; disease; levels; patients; sars cache: cord-256893-3sh87h2x.txt plain text: cord-256893-3sh87h2x.txt item: #740 of 2876 id: cord-257035-ob1xncbs author: Rigatelli, Gianluca title: Intubation and Ventilation amid COVID-19: Comment date: 2020-05-11 words: 732 flesch: 28 summary: The recent published literature regarding the occurrence of acute respiratory syndrome (ARDS) in COVID-19 patients have mainly focused attention on the role of computed tomography in evaluating the radiological manifestations and temporal progression of the disease, 2 while few data have been presented regarding the use of lung ultrasonography, 3 especially in the evaluation of the disease course. 5 Indeed, ultrasound could be a viable option to reduce the need to transport patients to the radiology department, reducing the exposure of hospital staff and other subjects to COVID-19 patients. keywords: covid-19; lung; patients cache: cord-257035-ob1xncbs.txt plain text: cord-257035-ob1xncbs.txt item: #741 of 2876 id: cord-257051-ntnfu5ns author: Tack, Christopher Topol title: “Physio Anywhere”: digitally-enhanced outpatient care as a legacy of coronavirus 2020 date: 2020-07-18 words: 1382 flesch: 32 summary: The shape, structure and processes of remote working practices in the future will be determined by the careful assessment of current services that have been delivered in response to the ongoing emergency situation. Clinical guidance on remote care during the emergency period was rapidly published both by NHS England keywords: exercise; patients; physiotherapy cache: cord-257051-ntnfu5ns.txt plain text: cord-257051-ntnfu5ns.txt item: #742 of 2876 id: cord-257147-i48qljv6 author: Karakas, Mahir title: Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101) date: 2020-08-11 words: 3505 flesch: 39 summary: Patients received a single dose of Adrecizumab at a dose of 4 mg/kg (2 patients) or 8 mg/kg (6 patients) body weight over a 1-h period. An observational cohort study A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2) Adrenomed Announces Positive Top-Line AdrenOSS-2 Phase II Results with Adrecizumab in Septic Shock Endothelial cell infection and endotheliitis in COVID-19 Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: Dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics Circulating dipeptidyl peptidase 3 and alteration in haemodynamics in cardiogenic shock: Results from the OptimaCC trial Dipeptidyl peptidase 3, a biomarker in cardiogenic shock and hopefully much more On Endogenous Angiotensin II Antagonism in Hypertension: The Role of Dipeptidyl Peptidase III World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects Changes in the German Medicinal Product Act imposed by the EU regulation on clinical trials Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system Intensive Care National Audit & Research Centre Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: keywords: adm; adrecizumab; case; covid-19; dose; patients; series cache: cord-257147-i48qljv6.txt plain text: cord-257147-i48qljv6.txt item: #743 of 2876 id: cord-257206-av2k44ig author: Chen, Ruey title: Effects of a SARS prevention programme in Taiwan on nursing staff's anxiety, depression and sleep quality: A longitudinal survey date: 2006-02-28 words: 5065 flesch: 56 summary: This research is to describe the anxiety level, depression level, and sleep quality of nursing staff who cared for SARS patients during a sweeping epidemic and the effects of a SARS prevention program. Previously known as atypical pneumonia, the World Health Organization (WHO) began using the term SARS on March 15, 2003 (http://www.who.int/ors/ sars). In summary, nursing staff caring for SARS patients experienced tremendous physical and mental stresses because so little was known about the disease transmission and effective treatment regimens. keywords: anxiety; care; depression; nursing; patients; sars; sleep; staff cache: cord-257206-av2k44ig.txt plain text: cord-257206-av2k44ig.txt item: #744 of 2876 id: cord-257274-fzyamd7v author: Peiro-Garcia, Alejandro title: How the COVID-19 pandemic is affecting paediatric orthopaedics practice: a preliminary report date: 2020-06-01 words: 3907 flesch: 46 summary: As the COVID-19 pandemic has interfered in our daily practice, we have found a decrease in the number of paediatric trauma patients admitted to our ED, the number of patients visiting onsite to our paediatric orthopaedic clinic and the number of elective cases compared with other years. In the same vein, despite our hospital being a university hospital and receiving residents and fellows from other hospitals, these were required by law to return to their home hospitals to assist with COVID-19 patients. keywords: cases; children; covid-19; number; orthopaedic; pandemic; patients; practice cache: cord-257274-fzyamd7v.txt plain text: cord-257274-fzyamd7v.txt item: #745 of 2876 id: cord-257276-h5542vqg author: Euchi, Jalel title: A Hybrid Approach to Solve the Vehicle Routing Problem with Time Windows and Synchronized Visits In-Home Health Care date: 2020-08-05 words: 7450 flesch: 52 summary: The home care crew scheduling problem: preference-based visit clustering and temporal dependencies Mathematical model and exact algorithm for the home care worker scheduling and routing problem with lunch break requirements Algorithms for the vehicle routing and scheduling problems with time window constraints PSO-based algorithm for home care worker scheduling in the UK A branch-price-and-cut approach for solving the medium-term home health care planning problem Joint assignment, scheduling, and routing models to home care optimization: a pattern-based approach Heuristic solutions for the vehicle routing problem with time windows and synchronized visits Local search analysis for a vehicle routing problem with synchronization and time windows constraints in home health care services A decision support system for home dialysis visit scheduling and nurse routing Ant colony system: a cooperative learning approach to the traveling salesman problem Beam-ACO for the travelling salesman problem with time windows An ant colony optimization model: the period vehicle routing problem with time windows A memetic algorithm for a home health care routing and scheduling problem Heuristic algorithms for a vehicle routing problem with simultaneous delivery and pickup and time windows in home health care Home care service planning. The case of Landelijke Thuiszorg Home Health Care Scheduling: A Case Study An analysis of generalised heuristics for vehicle routing and personnel rostering problems Daily scheduling of home health care services using time-dependent public transport A GRASP × keywords: acs; algorithm; care; health; home; patients; problem; routing; scheduling; set; time; vehicle; visits cache: cord-257276-h5542vqg.txt plain text: cord-257276-h5542vqg.txt item: #746 of 2876 id: cord-257309-sazs5wgh author: Ho, Hsi-en title: Clinical Outcomes and Features of Covid-19 in Patients with Primary Immunodeficiencies in New York City date: 2020-10-08 words: 1344 flesch: 41 summary: Main Text: Coronavirus disease 2019 (Covid-19) remains an ongoing pandemic, and data on the clinical impact of SARS-CoV-2 infection in patients with primary immunodeficiency diseases (PIDs) are limited (1) (2) (3) . Here, we report the clinical features and outcomes of Covid-19 in patients from a large PID center in New York City during this period. keywords: cells; covid-19; patients; pid cache: cord-257309-sazs5wgh.txt plain text: cord-257309-sazs5wgh.txt item: #747 of 2876 id: cord-257336-rpx71ww5 author: Doukas, Sotirios G. title: E-cigarette or vaping induced lung injury: A case series and literature review date: 2020-10-03 words: 4719 flesch: 45 summary: Future studies focusing on the comparison of clinical, laboratory and imaging findings of EVALI patients with patients presenting with similar respiratory conditions, with similar clinical manifestations, such as COVID-19, will contribute significantly in the development of standardized approach for EVALI diagnosis and treatment. EVALI patients with radiological findings of lung injury, although mainly present respiratory symptoms, may very often appear with constitutional and gastrointestinal symptoms. keywords: cases; cigarette; disease; evali; lung; patients; table; use; vaping cache: cord-257336-rpx71ww5.txt plain text: cord-257336-rpx71ww5.txt item: #748 of 2876 id: cord-257344-d13at1y5 author: Ghasemiyeh, Parisa title: COVID-19 Outbreak: Challenges in Pharmacotherapy Based on Pharmacokinetic and Pharmacodynamic Aspects of Drug Therapy in Patients with Moderate to Severe Infection date: 2020-09-18 words: 5690 flesch: 35 summary: According to recently published researches, the most common clinical presentations in COVID-19 patients were fever in 83% to 98% of patients, dry cough in 76 to 82%, and fatigue or myalgia in 11 to 44% of them. So close patient monitoring is required in COVID-19 patients with pre-existing cardiovascular disease who are planned to treat with lopinavir/ritonavir and sometimes alternative drugs might be considered 52 . keywords: antiviral; chloroquine; coronavirus; covid-19; disease; drug; hydroxychloroquine; lopinavir; patients; potential; ribavirin; ritonavir; treatment cache: cord-257344-d13at1y5.txt plain text: cord-257344-d13at1y5.txt item: #749 of 2876 id: cord-257408-ejhhk1iu author: Goss, Matthew B. title: The Pediatric Solid Organ Transplant Experience with COVID‐19: An Initial Multi‐Center, Multi‐Organ Case Series date: 2020-09-18 words: 2295 flesch: 39 summary: As our patients presented with mild symptoms and most recovered within days, and less than half had evaluation of serum inflammatory biomarkers, we are unable to determine the meaning and role of assessment of inflammatory biomarkers in pediatric transplant patients. It will be critical to learn from and share our experience through the post-COVID-19 diagnosis and recovery period, with a focus on antibody kinetics and risk for re-infection, as we seek to understand the potential longterm effects of COVID-19 infection in immunosuppressed pediatric transplant patients. keywords: covid-19; patients; pediatric; recipients; symptoms; transplant cache: cord-257408-ejhhk1iu.txt plain text: cord-257408-ejhhk1iu.txt item: #750 of 2876 id: cord-257433-qgkwylmk author: Candeloro, Elisa title: An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era date: 2020-10-15 words: 3563 flesch: 51 summary: Our data showed that despite the fact that the COVID-19 pandemic imposed a reallocation of health system resources, largely toward the management of COVID-19 patients, we were still able to guarantee a timely and safe approach for stroke patients. This is because most of the resources normally available in hospitals had to be devoted to the treatment of COVID-19 patients. keywords: covid-19; door; hospital; patients; period; stroke; time cache: cord-257433-qgkwylmk.txt plain text: cord-257433-qgkwylmk.txt item: #751 of 2876 id: cord-257467-b8o5ghvi author: Smith, Barbara A. title: Anesthesia as a Risk for Health Care Acquired Infections date: 2010-12-31 words: 4508 flesch: 38 summary: Measures to reduce infection risk associated with intubation and mechanical ventilation deal with technique and equipment. Health care associated infections involving anesthesia have been transmitted from health care worker to patient, patient to patient, and patient to the anesthesia provider. keywords: anesthesia; care; colleagues; contamination; health; infection; intubation; patient; risk; use cache: cord-257467-b8o5ghvi.txt plain text: cord-257467-b8o5ghvi.txt item: #752 of 2876 id: cord-257504-tqzvdssb author: Dubost, Clément title: Preparation of an intensive care unit in France for the reception of a confirmed case of Ebola virus infection() date: 2015-11-24 words: 5150 flesch: 54 summary: It is now clear that northern countries will be implicated in the care of EVD patients, both in the field and back at home. It is now clear that northern countries will be implicated in the care of EVD patients, both in the field and back at home. keywords: care; case; disease; ebola; evd; icu; patient; risk; room; staff; virus cache: cord-257504-tqzvdssb.txt plain text: cord-257504-tqzvdssb.txt item: #753 of 2876 id: cord-257600-0plhquk9 author: Calles, Antonio title: Outcomes of COVID-19 in Patients With Lung Cancer Treated in a Tertiary Hospital in Madrid date: 2020-09-16 words: 6983 flesch: 43 summary: We aimed to analyze outcomes of lung cancer patients affected by COVID-19 in a tertiary hospital of a high-incidence region during the pandemic. Conclusions: Lung cancer patients represent a vulnerable population for COVID-19, according to the high rate of hospitalization, onset of ARDS, and high mortality rate. keywords: cancer; cancer patients; cases; cov-2; covid-19; lung; lung cancer; mortality; patients; sars; therapy; treatment cache: cord-257600-0plhquk9.txt plain text: cord-257600-0plhquk9.txt item: #754 of 2876 id: cord-257696-ybu772zw author: Bartoletti, Michele title: Efficacy of corticosteroid treatment for hospitalized patients with severe COVID-19: a multicenter study date: 2020-09-22 words: 921 flesch: 38 summary: key: cord-257696-ybu772zw authors: Bartoletti, Michele; Marconi, Lorenzo; Scudeller, Luigia; Pancaldi, Livia; Tedeschi, Sara; Giannella, Maddalena; Rinaldi, Matteo; Bussini, Linda; Valentini, Ilaria; Ferravante, Anna Filomena; Potalivo, Antonella; Marchionni, Elisa; Fornaro, Giacomo; Pascale, Renato; Pasquini, Zeno; Puoti, Massimo; Merli, Marco; Barchiesi, Francesco; Volpato, Francesca; Rubin, Arianna; Saracino, Annalisa; Tonetti, Tommaso; Gaibani, Paolo; Ranieri, Vito Marco; Viale, Pierluigi; Cristini, Francesco title: Efficacy of corticosteroid treatment for hospitalized patients with severe COVID-19: a multicenter study date: 2020-09-22 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2020.09.014 sha: doc_id: 257696 cord_uid: ybu772zw OBJECTIVES: In this study we were not able to find a lower mortality rate among hospitalized patients Characteristics of and Important Lessons From the Coronavirus 333 Disease 2019 (COVID-19) Outbreak in China Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With Critical Care Utilization for the COVID-19 Outbreak in Early Experience and Forecast During an Emergency Response Clinical features of patients infected with 2019 novel 346 coronavirus in Wuhan Development and validation of 351 a prediction model for severe respiratory failure in hospitalized patients with SARS-Cov-2 infection: 352 a multicenter cohort study (PREDI-CO study), Clinical microbiology and infection : the official Tocilizumab in patients with severe COVID-19: a retrospective 362 cohort study Impact of corticosteroid therapy 364 on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic 365 review and meta-analysis Dexamethasone in Hospitalized Patients with Covid-19 -Preliminary Methylprednisolone as Adjunctive Therapy for Patients Hospitalized With COVID-19 (Metcovid): A Placebo-Controlled Trial keywords: covid-19; patients; treatment cache: cord-257696-ybu772zw.txt plain text: cord-257696-ybu772zw.txt item: #755 of 2876 id: cord-257717-fbfe5vt4 author: Wallis, Christopher J.D. title: The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future date: 2020-09-04 words: 7915 flesch: 31 summary: Overall, the goal is to treat cancer patients with as close to standard therapies as possible once the risk/ benefit ratio has been considered. For cancer patients, including those within bench research, clinical trials, observational studies, realworld effectiveness of agents, and randomised trials, support is derived from research staff and well-being from knowledge that you are helping other patients [110] . keywords: approach; bladder; cancer; care; covid-19; health; hospital; impact; outcomes; pandemic; patients; prostate; research; risk; surveillance; telemedicine; treatment; trial cache: cord-257717-fbfe5vt4.txt plain text: cord-257717-fbfe5vt4.txt item: #756 of 2876 id: cord-257729-s0vo7dlk author: Bauer, Melissa title: Obstetric Anesthesia During the Coronavirus Disease 2019 Pandemic date: 2020-04-20 words: 4289 flesch: 28 summary: In principle, the clinical characteristics reported in pregnant women with confirmed COVID-19 infection in China have been consistent with those reported among nonpregnant adults, with better maternal and neonatal outcomes with COVID-19 infection compared with the 2002-2003 severe acute respiratory syndrome (SARS) outbreak from SARS CoV 1 infection. It is imperative to establish a back-up team to care for patients without COVID-19 infection due to the time-intensive tasks of donning/doffing PPE, transporting the patient, providing anesthetic care, and performing surgery in patients with active COVID-19 infection. keywords: anesthesia; care; cesarean; coronavirus; covid-19; delivery; infection; labor; patients; women cache: cord-257729-s0vo7dlk.txt plain text: cord-257729-s0vo7dlk.txt item: #757 of 2876 id: cord-257732-3xuy6tbn author: Azzi, Lorenzo title: Saliva is a reliable tool to detect SARS-CoV-2 date: 2020-04-14 words: 3516 flesch: 48 summary: This study analyzed salivary samples of COVID-19 patients and compared the results with their clinical and laboratory data. Indeed, LDH is commonly released during tissue damage, it can be associated to the lung damage that takes place in COVID-19 patients. keywords: cov-2; covid-19; patients; saliva; salivary; sars; values cache: cord-257732-3xuy6tbn.txt plain text: cord-257732-3xuy6tbn.txt item: #758 of 2876 id: cord-257781-ybpliz32 author: Jones, Eben title: Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax in Critically Ill Patients With Coronavirus Disease 2019: A Retrospective Cohort Study date: 2020-09-17 words: 3478 flesch: 39 summary: The median duration of illness prior to critical care admission was 3 days longer in barotrauma patients (10 vs 7 d; IQR 8-14 and 6-10, respectively; p = 0.073). Second, barotrauma patients also tended to have a longer disease course prior to critical care admission. keywords: barotrauma; care; covid-19; median; patients; pressure; support; ventilation cache: cord-257781-ybpliz32.txt plain text: cord-257781-ybpliz32.txt item: #759 of 2876 id: cord-257839-kfzc4pwq author: Ferguson, Katie title: COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis date: 2020-08-03 words: 2809 flesch: 43 summary: Incidence of venous thromboembolism in hospitalized patients with COVID-19 Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in The British Thoracic Society. [1] [2] [3] [4] Expert guidance currently recommends higher than standard doses of prophylactic anticoagulation for patients with COVID-19 requiring critical care. keywords: arterial; case; covid-19; day; left; limb; patients; pulmonary cache: cord-257839-kfzc4pwq.txt plain text: cord-257839-kfzc4pwq.txt item: #760 of 2876 id: cord-257884-5exwwxin author: Kumar, Rajesh title: Acute pericarditis as a primary presentation of COVID-19 date: 2020-08-18 words: 2112 flesch: 51 summary: [4] [5] [6] One reported COVID-19 case with upper respiratory tract symptoms had haemorrhagic pericardial effusion with tamponade. key: cord-257884-5exwwxin authors: Kumar, Rajesh; Kumar, Jathinder; Daly, Caroline; Edroos, Sadat Ali title: Acute pericarditis as a primary presentation of COVID-19 date: 2020-08-18 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-237617 sha: doc_id: 257884 cord_uid: 5exwwxin The COVID-19 pandemic is a highly contagious viral illness which conventionally manifests primarily with respiratory symptoms. keywords: acute; cardiac; case; covid-19; pain; pericarditis cache: cord-257884-5exwwxin.txt plain text: cord-257884-5exwwxin.txt item: #761 of 2876 id: cord-258027-f3rr5el1 author: Østby, Anne‐Cathrine title: Respiratory virology and microbiology in intensive care units: a prospective cohort study date: 2013-05-18 words: 5260 flesch: 33 summary: In conclusion, respiratory viruses were frequently detected in the patients. The investigated clinical and paraclinical parameters were not different in viral infections compared to other agents, thus respiratory viruses likely have similar impact on the clinical course as other agents. keywords: bacteria; icu; influenza; patients; results; study; virus; viruses cache: cord-258027-f3rr5el1.txt plain text: cord-258027-f3rr5el1.txt item: #762 of 2876 id: cord-258067-par61wwh author: Di Martino, Marcello title: Elective Surgery During the SARS-CoV-2 Pandemic (COVID-19): A Morbimortality Analysis and Recommendations on Patient Prioritisation and Security Measures date: 2020-06-20 words: 3466 flesch: 32 summary: Therefore, when reporting the morbidity and mortality of surgical patients with the COVID-19 infection, the severity of complications will be indicated according to the Dindo-Clavien classification (19) ; the therapeutic measures used with each patient according to a classification of treatments required (as described in Table 1 ) and the severity of the respiratory infection according to the Brescia respiratory COVID-19 severity scale (BRCSS) (20) . A Retrospective Cohort Study in a Designated Hospital of Wuhan in China ASA classification and perioperative variables as predictors of postoperative outcome Predictive Factors of Pancreatic Fistula After Pancreaticoduodenectomy and External Validation of Predictive Scores Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases Predictive factors for anastomotic leakage after laparoscopic colorectal surgery Frailty and post-operative outcomes in older surgical patients: a systematic review AASLD guidelines for the treatment of hepatocellular carcinoma Systematic review and meta-analysis of local ablative therapies for resectable colorectal liver metastases Endoscopic resection techniques for colorectal neoplasia: Current developments A watch-and-wait approach for locally advanced rectal cancer after a clinical complete response following neoadjuvant chemoradiation: a systematic review and meta-analysis keywords: complications; covid-19; infection; pandemic; patients; sars; surgery cache: cord-258067-par61wwh.txt plain text: cord-258067-par61wwh.txt item: #763 of 2876 id: cord-258093-6fn8ei9f author: Hanania, Nicola A. title: Asthma in the elderly: Current understanding and future research needs—a report of a National Institute on Aging (NIA) workshop date: 2011-08-25 words: 17068 flesch: 41 summary: The aging lung Large, longitudinal, and more complete studies to determine the effects of aging on the function of the respiratory system Improved knowledge about lung structure-function relationships in older age using techniques of imaging and measures of lung function not requiring effort (eg, high-resolution computed tomographic scanning and forced oscillation) Improved assessment of lung processes underlying airflow limitation attributable to aging versus COPD or asthma, especially in asthmatic patients who smoke Studies to examine the effects of aging in ethnic groups and the role of gender Epidemiology, effect, diagnosis, and management Determine the true prevalence and cost of asthma in the older population Develop a uniform definition of asthma to be applied to health care records that will distinguish asthma from COPD and mixed asthma/COPD Evaluate evidence-based treatment algorithms for older asthmatic patients, such as those developed by the National Heart, Lung, and Blood Institute and Global Initiative For Asthma guidelines 7 Assess the effect of asthma treatment, including direct medical costs of care, indirect costs of care, and value of treatment in improving quality of life 8, 9 Assess the effect of comorbid conditions, especially COPD and congestive heart failure, on asthma 9 Characterize phenotypes of elderly asthma with regard to responses to therapy and long-term outcomes based on age of onset, duration of disease, and environmental triggers Develop algorithms for electronic medical record systems that are asthma-specific Evaluate effects of current asthma medications in older patients compared with younger patients Identify pharmacogenetic determinants of response to asthma medications in older adults Identify simpler and safer drug delivery systems and schedules for older adults Develop simple methods to differentiate COPD from asthma exacerbations in older adults Understand how environmental or aging-related factors affect epigenetic changes in asthma in older adults Identify differences between older and younger asthmatic patients or between LSA and LOA with regard to inflammation, remodeling, intracellular mechanisms, responses to environmental pollutants, and allergy sensitization and their effects on the metabolism and action of asthma drugs Identify naturally occurring age-related changes in airway cellular patterns Develop animal models of age-related airway inflammation Understand the significance of allergy sensitization associated with asthma in older adults (eg, through larger prospective studies) 97, 124, 128 Patients with LOA start having asthma symptoms for the first time when they are 65 years of age or older (some studies have suggested middle age or older). keywords: adults; age; aging; airway; asthma; care; changes; control; copd; diagnosis; disease; effects; elderly; function; group; health; inflammation; life; lung; patients; population; response; studies; study; subjects; symptoms; treatment; years cache: cord-258093-6fn8ei9f.txt plain text: cord-258093-6fn8ei9f.txt item: #764 of 2876 id: cord-258113-mnou31j3 author: Wang, Yaping title: Clinical Characteristics of Patients Infected With the Novel 2019 Coronavirus (SARS-Cov-2) in Guangzhou, China date: 2020-05-19 words: 3900 flesch: 52 summary: Imported group patients were those who had been to Wuhan within 14 days or who were residents of Wuhan before admission, and the local group included patients who had not left Guangdong during the past month. So it is important to evaluate ALB levels dynamically in these patients. RT-PCR analysis of respiratory or fecal samples, together with serological testing, can confirm the diagnosis of SARS-CoV infection in most SARS patients. keywords: coronavirus; cov-2; disease; group; patients; sars; study; wuhan cache: cord-258113-mnou31j3.txt plain text: cord-258113-mnou31j3.txt item: #765 of 2876 id: cord-258117-5gpo8smn author: Le Naour, Julie title: Trial watch: IDO inhibitors in cancer therapy date: 2020-06-14 words: 8578 flesch: 24 summary: Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance Metabolomic adaptations and correlates of survival to immune checkpoint blockade Marrying immunotherapy with chemotherapy: why say IDO? Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase Immunomodulatory monoclonal antibodies in combined immunotherapy trials for cutaneous melanoma Combination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies Combining immune checkpoint inhibitors: established and emerging targets and strategies to improve outcomes in melanoma IDO inhibitors move center stage in immuno-oncology Cady SG, Sono M. 1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses Levo-but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer Indoximod: an immunometabolic adjuvant that empowers T cell activity in cancer Tryptophan metabolism in inflammaging: from biomarker to therapeutic target Indoleamine 2,3-dioxygenase provides adaptive resistance to immune checkpoint inhibitors in hepatocellular carcinoma Increased indoleamine 2,3-dioxygenase activity and expression in prostate cancer following targeted immunotherapy IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death Cyclindependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone An albumin-bound drug conjugate of paclitaxel and indoleamine-2,3-dioxygenase inhibitor for enhanced cancer chemo-immunotherapy Enlightening the impact of immunogenic cell death in photodynamic cancer therapy ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death Extracorporeal photochemotherapy induces bona fide immunogenic cell death Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity STAT3 inhibition enhances the therapeutic efficacy of immunogenic chemotherapy by stimulating type 1 interferon production by cancer cells STATs in cancer inflammation and immunity: a leading role for STAT3 Targeting the IL-6/JAK/ STAT3 signalling axis in cancer Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR Heme-containing enzymes and inhibitors for tryptophan metabolism IDO targeting in sarcoma: biological and clinical implications Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1 Inhibition of Indoleamine 2,3-dioxygenase enhances the therapeutic efficacy of immunogenic chemotherapeutics in breast cancer Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death PF-06840003: a highly selective IDO-1 inhibitor that shows good in vivo efficacy in combination with immune checkpoint inhibitors Characterization of the selective indoleamine 2,3-dioxygenase-1 (IDO1) catalytic inhibitor EOS200271/PF-06840003 Supports IDO1 as a critical resistance mechanism to PD-(L)1 blockade therapy IDO1 inhibition synergizes with radiation and pd-1 blockade to durably increase survival against advanced glioblastoma Optimising efficacy and reducing toxicity of anticancer radioimmunotherapy Modulating tumor immunology by inhibiting indoleamine 2,3-dioxygenase (IDO): recent developments and first clinical experiences Identification of novel imidazoles as IDO1 inhibitors through microwave-assisted one-pot multicomponent reactions Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase 3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment Discovery of IDO1 Inhibitors: from Bench to Bedside Indoleamine 2,3-dioxygenase expression pattern in the tumor microenvironment predicts clinical outcome in early stage cervical cancer The landscape of cancer cell line metabolism Recent advances in the development of anti-HER2 antibodies and antibody-drug conjugates Mechanism of action of anti-HER2 monoclonal antibodies Immune checkpoint inhibition overcomes ADCP-induced immunosuppression by macrophages Antibody-dependent cellular cytotoxicity renders macrophages immunosuppressive Control of metastasis by NK Cells Cytosolic DNA sensing in organismal tumor control Natural and therapy-induced immunosurveillance in breast cancer Blockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus standard-of-care chemotherapy in women with hormone receptor-positive, HER2-positive advanced breast cancer (monarcHER): a randomised, open-label, phase 2 trial Impact of breast cancer treatment on employment: results of a multicenter prospective cohort study (CANTO) Nivolumab for the treatment of bladder cancer A phase II, randomized study of nivolumab (nivo) or nivo plus BMS-986205 with or without intravesical Bacillus Calmette-Guerin (BCG) in BCG-unresponsive, high-risk, non-muscle invasive bladder cancer (NMIBC): checkMate 9UT A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer Trial Watch: toll-like receptor agonists in cancer immunotherapy Pharmacological modulation of nucleic acid sensors -therapeutic potential and persisting obstacles The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4 Simultaneous blocking of human toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by mycobacterium bovis bacillus calmette-guerin peptidoglycan Trial watch: experimental Toll-like receptor agonists for cancer therapy Percutaneous BCG enhances innate effector antitumor cytotoxicity during treatment of bladder cancer: a translational clinical trial Combined assessment of peritumoral Th1/Th2 polarization and peripheral immunity as a new biomarker in the prediction of BCG response in patients with high-risk NMIBC Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium Bacillus Calmette Guerin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapy Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury Cisplatin-induced immune modulation in ovarian cancer mouse models with distinct inflammation profiles Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer Pooled analysis of clinical outcomes with neoadjuvant cisplatin and gemcitabine chemotherapy for muscle invasive bladder cancer Metabolic vulnerability of cisplatin-resistant cancers Gemcitabine alters the proteasome composition and immunopeptidome of tumour cells Low dose gemcitabine increases the cytotoxicity of human Vgamma9Vdelta2 T cells in bladder cancer cells in vitro and in an orthotopic xenograft model ENERGIZE: a Phase III study of neoadjuvant chemotherapy alone or with nivolumab with/without linrodostat mesylate for muscle-invasive bladder cancer Nivolumab plus ipilimumab in lung cancer with a high tumor mutational burden Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial Immunotherapy for urothelial carcinoma: current evidence and future directions Adding indoximod to hypofractionated radiotherapy with anti-PD-1 checkpoint blockade enhances early NK and CD8(+) T-cell-dependent tumor activity Molecular pathways: targeting IDO1 and other tryptophan dioxygenases for cancer immunotherapy Effect of combined anti-PD-1 and temozolomide therapy in glioblastoma Survival gain in glioblastoma patients treated with dendritic cell immunotherapy is associated with increased NK but not CD8+T cell activation in the presence of adjuvant temozolomide Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma Cyclophosphamide induces type I interferon and augments the number of CD44(hi) keywords: cancer; cell; clinical; dioxygenase; efficacy; epacadostat; ido1; immune; indoleamine; inhibitor; patients; phase; results; study; therapy; trial; tryptophan; tumor cache: cord-258117-5gpo8smn.txt plain text: cord-258117-5gpo8smn.txt item: #766 of 2876 id: cord-258128-qtmjgrml author: Mirjalili, Mahtabalsadat title: Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen date: 2020-07-03 words: 6459 flesch: 30 summary: Table 1 shows a summary of medications which are used or suggested for the management of COVID-19 patients, according to recent studies. Sometimes, medications other than antivirals are used for symptomatic therapy or supportive care in COVID-19 patients. keywords: coronavirus; covid-19; drug; effects; kidney; liver; management; patients; recipients; risk; studies; transplant; treatment; use cache: cord-258128-qtmjgrml.txt plain text: cord-258128-qtmjgrml.txt item: #767 of 2876 id: cord-258133-zsweppku author: Fischer, M. title: COVID-19 paranoia in a patient suffering from schizophrenic psychosis – a case report date: 2020-04-17 words: 1129 flesch: 37 summary: key: cord-258133-zsweppku authors: Fischer, M.; Coogan, A.N.; Faltraco, F.; Thome, J. title: COVID-19 paranoia in a patient suffering from schizophrenic psychosis – a case report date: 2020-04-17 journal: Psychiatry Res DOI: 10.1016/j.psychres.2020.113001 sha: doc_id: 258133 cord_uid: zsweppku nan The COVID-19 pandemic affects mental health, both in healthcare settings and broader society. However, the number of studies addressing such issues is very limited; one such study carried out during the 2009 swine influenza pandemic indicated that patients with schizophrenia and a high level of predicted fear tended to judge their own risk of infection as higher (Maguire et al., 2019a ). keywords: case; covid-19; patient; report cache: cord-258133-zsweppku.txt plain text: cord-258133-zsweppku.txt item: #768 of 2876 id: cord-258278-25rhf91v author: Mowla, Ashkan title: Unusual Pattern of Arterial Macrothrombosis Causing Stroke in a Young Adult Recovered from COVID-19 date: 2020-09-25 words: 2057 flesch: 39 summary: (1,2,3,9 ,10) Our patient characteristics and imaging findings were notable for the following aspects: Young Age: The majority of COVID-19 patients with large vessel stroke reported thus far were older with underlying co-morbidities and conventional cardiovascular risk factors. This is in line with the outcome of other young COVID-19 patients with large vessel stroke reported thus far displaying poor prognosis. keywords: covid-19; infection; patient; stroke; symptoms; vessel cache: cord-258278-25rhf91v.txt plain text: cord-258278-25rhf91v.txt item: #769 of 2876 id: cord-258293-7q9zj8c2 author: Marini, Alessandra title: Letter to the Editor Regarding 'Coronavirus Disease 2019 (COVID-19) and Neurosurgery: Literature and Neurosurgical Societies Recommendations Update' date: 2020-05-26 words: 921 flesch: 25 summary: During the last three months, from February to 1 April 2020, despite the halving of the elective cases in the weekly schedule, due to the re-distribution of the 2 staff, the number of oncological patients who underwent a surgical treatment in our department was 3 approximately analogous to the same time-period in 2019 (February-April, 49 patients in 2020 and 45 patients 4 in 2019). In such intense atmosphere, neurosurgical departments 9 are balancing between the urgent and emergency cases, public-opinion concerns about transmission and the 0 safety of the staff and patients. keywords: covid-19; emergency; patients cache: cord-258293-7q9zj8c2.txt plain text: cord-258293-7q9zj8c2.txt item: #770 of 2876 id: cord-258315-yt1ytasw author: Kato, Hideaki title: Clinical course of 2019 novel coronavirus disease (COVID-19) in individuals present during the outbreak on the Diamond Princess cruise ship date: 2020-05-13 words: 1778 flesch: 50 summary: Because individuals with severe conditions during an outbreak are possibly transferred to nearby local hospitals, managing patients during an outbreak is a big challenge to local medical systems. The conditions and clinical courses of patients with pneumonia were compared with those of patients without pneumonia. keywords: covid-19; cruise; patients; pneumonia; ship cache: cord-258315-yt1ytasw.txt plain text: cord-258315-yt1ytasw.txt item: #771 of 2876 id: cord-258402-9s57thvn author: Dabas, Vineet title: Management of Orthopaedic Accidental Emergencies Amidst COVID-19 Pandemic: Our Experience in Preparing to Live with Corona date: 2020-09-10 words: 3714 flesch: 49 summary: All the wastes pertaining to COVID-19 patients (suspects/positives) were discarded in dedicated yellow bags, be it plastic/ cotton/latex or human waste. Suspected COVID-19 patients who were stable but had a clear-cut need for surgery, like femoral neck fractures, closed displaced intra-articular fractures, irreducible long bone fractures, etc. were given primary treatment in the form of fluids, temporary stabilization with splints, plasters and dressings. keywords: care; covid-19; health; management; orthopaedic; patients; period; surgery cache: cord-258402-9s57thvn.txt plain text: cord-258402-9s57thvn.txt item: #772 of 2876 id: cord-258416-1jrbu8ox author: Drenovska, Kossara title: Covid‐19 pandemic and the skin date: 2020-09-21 words: 1986 flesch: 26 summary: Coronavirus Illinois Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients Chilblains are a common cutaneous finding during the COVID-19 pandemic: a retrospective nationwide study from France Characterization of acute acro-ischemic lesions in nonhospitalized patients: a case series of 132 patients during the COVID-19 outbreak Coagulopathy and antiphospholipid antibodies in patients with Covid-19 Viral infections and antiphospholipid antibodies COVID-19 can present with a rash and be mistaken for dengue Reply to COVID-19 can present with a rash and be mistaken for dengue: Petechial rash in a patient with COVID-19 infection A dermatologic manifestation of COVID-19: transient livedo reticularis Histopathological study of 3 cases of new coronavirus pneumonia (COVID-19) with multi-site puncture Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases SARS-COV-2 infection is likely to be androgen mediated A preliminary observation: Male pattern hair loss among hospitalized COVID-19 patients in Spain -A potential clue to the role of androgens in COVID-19 severity What does androgenetic alopecia have to do with COVID-19? Case Rep Pediatr Clinical characteristics of children with viral single-and co-infections and a petechial rash Cutaneous manifestations in COVID-19: a first perspective Comment on 'Cutaneous manifestations in COVID-19: a first perspective' by Recalcati S A case of COVID-19 pneumonia in a young male with full body rash as a presenting symptom Rash as a clinical manifestation of COVID19. keywords: coronavirus; covid-19; disease; pandemic; patients; skin cache: cord-258416-1jrbu8ox.txt plain text: cord-258416-1jrbu8ox.txt item: #773 of 2876 id: cord-258498-0mvxwo3w author: Shah, Saleha title: COVID-19 and paediatric dentistry- traversing the challenges. A narrative review date: 2020-08-21 words: 13563 flesch: 44 summary: DHCP recovered from COVID-19 (protective immunity) care for COVID-19 patient. DHCP recovered from COVID-19 (protective immunity) care for COVID-19 patient. keywords: advice; air; care; caries; children; control; covid-19; day; dhcp; dose; emergency; face; fluoride; infection; management; nsaids; pain; patient; risk; symptoms; tooth; transmission; use; water; years cache: cord-258498-0mvxwo3w.txt plain text: cord-258498-0mvxwo3w.txt item: #774 of 2876 id: cord-258548-1u7v1nlr author: Mansueto, Gelsomina title: Can COVID 2019 disease induces a specific cardiovascular damage or it exacerbates pre-existing cardiovascular diseases? date: 2020-06-26 words: 5929 flesch: 25 summary: Heart damage patients had higher mortality than those without heart damage. The 3 main symptoms of COVID-19 disease are fever, cough, and shortness of breath. keywords: acute; cells; cov-2; covid-19; damage; disease; heart; infection; inflammatory; patients; risk; sars; study; virus cache: cord-258548-1u7v1nlr.txt plain text: cord-258548-1u7v1nlr.txt item: #775 of 2876 id: cord-258576-ywbyflas author: Bösmüller, Hans title: The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation date: 2020-06-30 words: 3638 flesch: 38 summary: The hypercoagulability may also contribute to the observed mortality by triggering cardiovascular events before the development of severe pulmonary disease [11, 20, 21] . In addition to severe pulmonary disease, disseminated coagulation and thrombus formation triggered by multifactorial endothelial damage are frequent events in fatal SARS-CoV-2 infection. keywords: alveolar; autopsy; covid-19; damage; disease; failure; il-6; patients; sars cache: cord-258576-ywbyflas.txt plain text: cord-258576-ywbyflas.txt item: #776 of 2876 id: cord-258583-5qdthy0j author: Yan, He title: Multiple organ injury on admission predicts in‐hospital mortality in patients with COVID‐19 date: 2020-09-30 words: 2584 flesch: 39 summary: World Health Organization Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Kidney disease is associated with inhospital death of patients with COVID-19 Clinical features and short-term outcomes of 102 patients with coronavirus disease Clinical characteristics of 82 cases of death from COVID-19 Acute myocardial injury at hospital admission is associated with all-cause mortality in COVID-19 Comorbid chronic diseases and acute organ injuries are strongly correlated with disease severity and mortality among COVID-19 patients: a systemic review and metaanalysis Clinical characteristics of 36 nonsurvivors with COVID-19 in Wuhan, China. However, it remains uncertain whether liver injury affects the mortality of COVID-19 patients, 4, 5 although it occurred more commonly in patients who had severe COVID-19 than mild ones. keywords: clinical; covid-19; disease; injury; mortality; patients cache: cord-258583-5qdthy0j.txt plain text: cord-258583-5qdthy0j.txt item: #777 of 2876 id: cord-258692-dch1utis author: Mead, Kenneth title: An evaluation of portable high-efficiency particulate air filtration for expedient patient isolation in epidemic and emergency response date: 2004-10-22 words: 5006 flesch: 34 summary: There were 3 key items of interest when the feasibility of the zone-within-zone isolation configurations was assessed: (1) ability to contain the source aerosol within the inner isolation zone(s); (2) ability to prevent source contaminant crossover between patient isolation zones in the 2-patient configuration; and (3) ability to maintain a lower concentration of source aerosol at the health care worker position relative to that surrounding the immediate patient position. Additional plastic sheeting was taped around the HEPA inlet to form a tight seal between the plastic curtain, Schematic showing a 20316 ft (635 m), 3-bed nonisolation hospital room expediently converted to contain isolation zones for 2 potentially infectious patients. keywords: aerosol; air; care; health; hepa; isolation; isolation zone; patient; source; unit; zone cache: cord-258692-dch1utis.txt plain text: cord-258692-dch1utis.txt item: #778 of 2876 id: cord-258708-da6x5rxa author: Hafiane, Anouar title: SARS-CoV-2 and the cardiovascular system date: 2020-07-16 words: 4043 flesch: 34 summary: Accumulating data points to an increased cardiovascular disease morbidity, and mortality in COVID-19 patients. COVID-19 patients presented with mild flu-like symptoms, and a few patients rapidly develop acute respiratory distress syndrome, respiratory failure, multiple organ failure, and even deaths ( Table 1 ). keywords: ace2; acute; angiotensin; cardiac; coronavirus; cov-2; covid-19; infection; patients; sars cache: cord-258708-da6x5rxa.txt plain text: cord-258708-da6x5rxa.txt item: #779 of 2876 id: cord-258727-mhg56j20 author: Kolar, Dusan title: Psychiatric emergency services and non-acute psychiatric services utilization during COVID-19 pandemic date: 2020-08-08 words: 429 flesch: 34 summary: Patients are well supported by their family members who stay at home during the COVID-19 lockdown and this experience of togetherness obviously was beneficial for patients with mood disorders. Many patients repeatedly emphasized that social distancing measures and isolation have a positive impact on them as all other people in the community are in the same position which helps with the burden of social isolation due to mental illness. keywords: covid-19; patients cache: cord-258727-mhg56j20.txt plain text: cord-258727-mhg56j20.txt item: #780 of 2876 id: cord-258758-sz8chn5e author: Resch, Tim title: Atypical COVID -19 presentation in patient undergoing staged TAAA repair date: 2020-05-16 words: 1297 flesch: 52 summary: This is 14 due to the fact that overall, the threshold for aneurysm repair at this time has been raised to 7cm. In the current case, the patient presented with symptoms of buttock claudication and leg 1 weakness, as in a Leriche syndrome (pain, fatigue, or cramping in the legs and buttocks, pale and 2 cold legs, and erectile dysfunction due to aorto-iliac occlusion), or of delayed onset SCI with 3 lower extremity weakness which has been described after endovascular TAAA repair. keywords: covid; patient; repair; symptoms cache: cord-258758-sz8chn5e.txt plain text: cord-258758-sz8chn5e.txt item: #781 of 2876 id: cord-258888-amimzjee author: Ananth, Lakshmi title: Management of ENT Surgical Emergencies Amidst COVID-19 Lockdown: Our Experience in a Tertiary Referral Hospital date: 2020-07-23 words: 3670 flesch: 44 summary: COVID-19 in India: potential impact of the lockdown and other longer-term policies The effects of the COVID-19/SARS-CoV-2 pandemic outbreak on otolaryngology activity in Italy Effect of COVID-19 related lockdown on ophthalmic practice and patient care in India: results of a survey Immediate and long term impact of the COVID 19 pandemic on delivery of surgical services ICMR: Revised Strategy of COVID19 testing in India Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China. Cancelling of routine OPDs and follow ups, discouraging of patients with non-emergency complaints from visiting the hospital, lack of availability of transport, inadequate testing facilities for asymptomatic patients and the fear of spread of infection to healthcare workers and other patients can all contribute to this. keywords: cases; covid-19; healthcare; hospital; infection; lockdown; patients; risk; testing cache: cord-258888-amimzjee.txt plain text: cord-258888-amimzjee.txt item: #782 of 2876 id: cord-258916-jbdz1pk0 author: Andreae, MH title: Data and Debriefing Observations on Healthcare Simulation to Prepare for the COVID-19 Pandemic: Healthcare Simulation for COVID-19 date: 2020-07-15 words: 2885 flesch: 33 summary: The first part of this scenario was conducted to provide another training opportunity for participants to cover key objectives presented in other simulation scenarios regarding team management in COVID-19 patients. [12] The same case was repeated with a different team leader and the group practiced the protocol that had been designed for COVID-19 patients for management of cardiac arrest. keywords: care; covid-19; participants; patient; room; simulation; team cache: cord-258916-jbdz1pk0.txt plain text: cord-258916-jbdz1pk0.txt item: #783 of 2876 id: cord-258930-60yn4hg7 author: D’Amico, Ferdinando title: Inflammatory bowel diseases and COVID-19: the invisible enemy date: 2020-04-16 words: 1028 flesch: 25 summary: Home patient management has been called telemedicine and it is a well-accepted approach by patients, as evidenced by the high adherence to home therapies or recommendations from physicians 22, 23 . Gut Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines IOIBD Update on COVID19 for Patients with Crohn's Disease and Ulcerative Colitis | IOIBD Management of IBD during the COVID-19 outbreak: resetting clinical priorities Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study European Crohn's and Colitis Organisation Topical Review on Treatment Withdrawal Facing Covid-19 in Italy -Ethics, Logistics, and Therapeutics on the Epidemic's Front Line Fair Allocation of Scarce Medical Resources in the Time of Covid-19 Implications of COVID-19 for patients with pre-existing digestive diseases Feasibility and acceptance of a home telemanagement system in patients with inflammatory bowel disease: a 6-month pilot study Telemedicine platform myIBDcoach reduces hospitalisations and outpatient gastroenterology visits in patients with IBD Amico declares no conflict of interest. keywords: covid-19; ibd; patients; risk cache: cord-258930-60yn4hg7.txt plain text: cord-258930-60yn4hg7.txt item: #784 of 2876 id: cord-259073-dixskemz author: Ward, Christine F. title: Altered Mental Status as a Novel Initial Clinical Presentation for COVID-19 Infection in the Elderly date: 2020-05-15 words: 2131 flesch: 41 summary: And, similar to the patients described in this brief report, a New York Times article citing physicians caring for COVID-19 patients also described patients presenting with confusion and AMS prior to developing a fever or respiratory illness We present four cases of elderly patients who developed altered mental status as their presenting symptom without associated fever or respiratory symptoms. keywords: covid-19; disease; patients; symptoms; virus cache: cord-259073-dixskemz.txt plain text: cord-259073-dixskemz.txt item: #785 of 2876 id: cord-259204-27t269pd author: Grimaldi, D. title: Characteristics and outcomes of Acute Respiratory Distress Syndrome related to COVID-19 in Belgian and French Intensive Care Units according to antiviral strategies. The COVADIS multicenter observational study. date: 2020-07-07 words: 3879 flesch: 45 summary: The Lancet HIV Ritonavir-induced acute kidney injury: kidney biopsy findings and review of literature Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China Kidney disease is associated with in-hospital death of patients with COVID-19 Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis Lopinavir pharmacokinetics in COVID-19 patients Comparison of Charlson comorbidity index with SAPS and APACHE scores for prediction of mortality following intensive care Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 Methods Observational multicenter cohort of patients with moderate to severe Covid-19 ARDS, comparing antiviral strategies (none, hydroxychloroquine (HCQ), lopinavir/ritonavir (L/R), others (combination or remdesivir). keywords: acute; aki; covid-19; data; day; patients; study; treatment; vfd cache: cord-259204-27t269pd.txt plain text: cord-259204-27t269pd.txt item: #786 of 2876 id: cord-259229-e8m8m4ut author: Samidurai, Arun title: Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic Strategies date: 2020-09-16 words: 10793 flesch: 30 summary: While the ACE2 gene is located on the X-chromosome, gender has an impact among COVID-19 patients, where men are at increased risk of susceptibility to COVID-19 infection and CVD complications due to their hemizygous allele for ACE2 compared to heterozygous allele in female [28] . Several promising therapeutics are under investigation to the overall prognosis of COVID-19 patients with high risk of cardiovascular impairment, nevertheless to date, none have shown proven clinical efficacy. keywords: ace2; acute; angiotensin; cardiac; cell; china; complications; coronavirus; cov-2; covid-19; covid-19 patients; disease; failure; heart; infection; mortality; patients; risk; sars; study; treatment; vaccine cache: cord-259229-e8m8m4ut.txt plain text: cord-259229-e8m8m4ut.txt item: #787 of 2876 id: cord-259329-8pta6o6a author: Haimovich, Adrian title: Development and validation of the quick COVID-19 severity index (qCSI): a prognostic tool for early clinical decompensation date: 2020-07-21 words: 4827 flesch: 38 summary: 7, 8 Given the high morbidity and mortality associated with COVID-19 and uncertainty around the disease process and prognosis, there is great urgency in developing and validating effective clinical risk stratification tools for COVID-19 patients. In a large cohort of COVID-19 patients, severe and critical illness represented almost 20% of the studied population. keywords: cohort; covid-19; data; hours; illness; model; patients; qcsi; risk; system; validation; values cache: cord-259329-8pta6o6a.txt plain text: cord-259329-8pta6o6a.txt item: #788 of 2876 id: cord-259411-434acu0h author: Aljehani, Faisal A. title: Inpatient Diabetes and Hyperglycemia Management Protocol in the COVID-19 Era date: 2020-07-06 words: 1462 flesch: 35 summary: Diabetes/metabolism research and reviews Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery) Efficacy of sitagliptin for the hospital management of general medicine and surgery patients with type 2 diabetes (Sita-Hospital): a multicentre, prospective, open-label, non-inferiority randomised trial Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study Glycaemic Efficacy and Safety of Linagliptin compared to Basal-Bolus Insulin Regimen in Patients with Type Diabetes Undergoing Non-Cardiac Surgery: A Multicenter Randomized Clinical Trial. key: cord-259411-434acu0h authors: Aljehani, Faisal A.; Funke, Katalina; Hermayer, Kathie L. title: Inpatient Diabetes and Hyperglycemia Management Protocol in the COVID-19 Era date: 2020-07-06 journal: Am J Med Sci DOI: 10.1016/j.amjms.2020.07.005 sha: doc_id: 259411 cord_uid: 434acu0h nan Diabetes and hyperglycemia are among the most common problems in hospitalized patients. keywords: diabetes; insulin; management; patients cache: cord-259411-434acu0h.txt plain text: cord-259411-434acu0h.txt item: #789 of 2876 id: cord-259448-deya8dwn author: Li, Caixia title: Differential microRNA expression in the peripheral blood from human patients with COVID‐19 date: 2020-09-22 words: 2662 flesch: 53 summary: The coronavirus disease (COVID‐19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which play important roles in regulating gene expression and are also considered as essential modulators during viral infection. Existing evidence suggests that miRNAs play critical roles in regulating gene expression by targeting the mRNAs of protein-coding genes. keywords: covid-19; expression; genes; hsa; mirnas; patients cache: cord-259448-deya8dwn.txt plain text: cord-259448-deya8dwn.txt item: #790 of 2876 id: cord-259585-mjtxiu0t author: Occhipinti, Vincenzo title: Challenges in the Care of IBD Patients During the CoViD-19 Pandemic: Report From a “Red Zone” Area in Northern Italy date: 2020-04-21 words: 2806 flesch: 40 summary: As a tertiary care center for IBD patients and one of the most prominent in the Milan metropolitan area, our IBD center from the very beginning of the CoViD-19 pandemic has been hit with a daily onslaught of phone calls and e-mails from our patients with concerns as to how the situation may affect them. Anecdotally, IBD patients do not appear to be at higher risk of developing CoViD-19 compared with the general population. keywords: covid-19; disease; hospital; ibd; patients; risk cache: cord-259585-mjtxiu0t.txt plain text: cord-259585-mjtxiu0t.txt item: #791 of 2876 id: cord-259699-48jg7ci7 author: González-Calatayud, Dra Mariel title: Observational study of the suspected or confirmed cases of sars COV-2 infection needing emergency surgical intervention during the first months of the pandemic in a third level hospital: Case series date: 2020-10-24 words: 2798 flesch: 38 summary: Discharge was indicated because of patient improvement in 23 cases (54.8%), death in 18 cases (42.9%), and 1 case is still hospitalized (2.4%) This can be explained because many of the General Surgery patients, in addition to their infectious process by COVID-19, had another complication, like sepsis, In the same way, we can say that pregnant patients are healthy and have a physiological condition. keywords: cases; covid-19; mortality; patients; sars; surgery cache: cord-259699-48jg7ci7.txt plain text: cord-259699-48jg7ci7.txt item: #792 of 2876 id: cord-259747-sl9q63oc author: Remmelink, Myriam title: Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date: 2020-08-12 words: 4549 flesch: 43 summary: key: cord-259747-sl9q63oc authors: Remmelink, Myriam; De Mendonça, Ricardo; D’Haene, Nicky; De Clercq, Sarah; Verocq, Camille; Lebrun, Laetitia; Lavis, Philomène; Racu, Marie-Lucie; Trépant, Anne-Laure; Maris, Calliope; Rorive, Sandrine; Goffard, Jean-Christophe; De Witte, Olivier; Peluso, Lorenzo; Vincent, Jean-Louis; Decaestecker, Christine; Taccone, Fabio Silvio; Salmon, Isabelle title: Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients date: 2020-08-12 journal: Crit Care DOI: 10.1186/s13054-020-03218-5 sha: doc_id: 259747 cord_uid: sl9q63oc BACKGROUND: Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients. Most of the previous post-mortem studies in COVID-19 patients were conducted using needle biopsies and were therefore rather limited in terms of sampling; our complete autopsy analysis identified considerable heterogeneity of SARS-CoV-2 spread through the human body and provides a more accurate description of macroscopic and microscopic organ alterations. keywords: acute; covid-19; findings; lung; organs; patients; pcr; samples; sars; study cache: cord-259747-sl9q63oc.txt plain text: cord-259747-sl9q63oc.txt item: #793 of 2876 id: cord-259767-x9s8qprc author: Harwayne-Gidansky, Ilana title: Recent Advances in Simulation for Pediatric Critical Care Medicine date: 2020-08-28 words: 4878 flesch: 27 summary: During the SARS-CoV-2 pandemic, simulation training was used on many levels for pandemic preparedness. For example, Ramanathan et al. described using simulation training on a team level in full PPE during provision of ECMO services during a pandemic [94] keywords: care; debriefing; education; healthcare; learning; outcomes; patient; pediatric; research; safety; simulation; skills; training cache: cord-259767-x9s8qprc.txt plain text: cord-259767-x9s8qprc.txt item: #794 of 2876 id: cord-259801-xuvcrvo2 author: Koch, Christian A. title: The Various Faces of Hyperthyroidism date: 2020-06-05 words: 2068 flesch: 24 summary: Zhou and colleagues underscore the important role of neural monitoring during thyroid surgery for Graves' disease in their retrospective series including 55 thyroidectomies and 82 procedures with intermittent intraoperative neuromonitoring (IONM) and 72 procedures with continuous IONM (19) . Pregnancy outcome in women treated with methimazole or propylthiouracil during pregnancy The value of total thyroidectomy as the definitive treatment for Graves' disease: a single centre experience of 594 cases Incidental parathyroidectomy during thyroid surgery does not cause transient symptomatic hypocalcemia Total Versus Neartotal Thyroidectomy in Graves Disease: Results of the Randomized Controlled Multicenter TONIG-trial Treatment options for Graves disease: a cost-effectiveness analysis How does neural monitoring help during thyroid sugery for Graves' disease? keywords: disease; graves; hyperthyroidism; patients; thyroid; thyroidectomy cache: cord-259801-xuvcrvo2.txt plain text: cord-259801-xuvcrvo2.txt item: #795 of 2876 id: cord-259848-0thzmh7k author: Sutera, Diana title: Management of Pediatric Rheumatological Diseases During the Outbreak of COVID-19: Our Experience date: 2020-07-01 words: 1127 flesch: 43 summary: 1 From studies in pediatric patients, performed in China, it appears that children of all ages are potentially susceptible to COVID-19, no gender differences were found. The clinical manifestations of pediatric patients generally seem less severe than those of adult patients. keywords: covid-19; drugs; infection; patients cache: cord-259848-0thzmh7k.txt plain text: cord-259848-0thzmh7k.txt item: #796 of 2876 id: cord-259907-yqmi0cqy author: Maxwell, Cynthia title: Management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS) No. 225, April 2009 date: 2009-10-31 words: 3421 flesch: 42 summary: The outcomes in pregnant SARS patients in Hong Kong appeared to be worse than outcomes in their non-pregnant counterparts. The overall number of staff was limited, and only a specific subgroup was assigned to the care of SARS pregnant patients. keywords: care; evidence; health; mother; patients; pregnancy; sars; syndrome cache: cord-259907-yqmi0cqy.txt plain text: cord-259907-yqmi0cqy.txt item: #797 of 2876 id: cord-259969-q65k590s author: Kösters, Katrin title: Cutaneous Vasculitis in a Patient With COVID-19 date: 2020-10-05 words: 829 flesch: 40 summary: However, other groups have described skin manifestations in up to 20% of COVID patients [4, 5] . However, our case demonstrates a small/medium-sized vessel vasculitis with involvement of mucous membranes as the cause of skin manifestations in a patient with COVID-19 that appeared late in the disease. keywords: covid-19; patient; skin cache: cord-259969-q65k590s.txt plain text: cord-259969-q65k590s.txt item: #798 of 2876 id: cord-259984-csdf1a69 author: Raffiq, Azman title: COVID-19 Pandemic and Its Impact on Neurosurgery Practice in Malaysia: Academic Insights, Clinical Experience and Protocols from March till August 2020 date: 2020-10-27 words: 16405 flesch: 43 summary: Clinical guide for the management of paediatric neurosurgery patients during the coronavirus pandemic Early lessons in the management of COVID-19 for the pediatric neurosurgical community from the leadership of the American Society of Pediatric Neurosurgeons Anaesthesia and sars Infographic for principles of airway management in COVID-19 World Federation of Societies of Anesthesiologists This publication is not a proposed National guideline for the COVID-19 Management of COVID-19 neurosurgical patients but a review of management and protocols from local and international peer reviewed and non-peer reviewed publications, web-based information and data until the month of August 2020. It is imperative to balance the requirements of caring for COVID-19 patients with imminent risk of delay to others who need care. keywords: airway; care; cases; covid-19; disease; emergency; health; hospital; icu; malaysia; management; medical; non; pandemic; patients; ppe; procedures; resources; risk; room; services; staff; stroke; surgery; team; treatment; use; ventilation cache: cord-259984-csdf1a69.txt plain text: cord-259984-csdf1a69.txt item: #799 of 2876 id: cord-260037-ys62jrgw author: Jecker, Nancy S. title: Ebola Virus Disease Ethics and Emergency Medical Response Policy date: 2015-09-30 words: 4562 flesch: 44 summary: Th e fragile web of responsibility: AIDS and the duty to treat The problem with rescue medicine Wrong Medicine: Doctors, Patients, and Futile Treatment Beyond futility to an ethic of care Ethical guidance on the use of life-sustaining therapies for patients with Ebola in developed countries Guidance paper: Ebola Treatment Centre (ETC): pregnant and lactating women Practice advisory: care of obstetric patients during an Ebola virus outbreak . Time Magazine Panic, paranoia, and public health-the AIDS epidemic's lessons for Ebola Doing today's work superbly well-treating Ebola with current tools Triage in medicine, part II: underlying values and principles Overwhelming casualties: medical ethics in a time of terror Triage: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement Ethical considerations: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement Ethical resource distribution aft er biological, chemical, or radiological terrorism Recognition of illness associated with the intentional release of a biologic agent Smallpox disease overview Randomised controlled trials for Ebola: practical and ethical issues Guidance for safe handling of human remains of Ebola patients by hospital and mortuaries Financial/nonfinancial disclosures: The authors have reported to CHEST that no potential confl icts of interest exist with any companies/ organizations whose products or services may be discussed in this article . keywords: care; disease; ebola; evd; health; patients; providers; resuscitation; risk cache: cord-260037-ys62jrgw.txt plain text: cord-260037-ys62jrgw.txt item: #800 of 2876 id: cord-260083-c1r9zn43 author: Lucatelli, Pierleone title: Heparin-Related Major Bleeding in Covid-19-Positive Patient: Perspective from the Outbreak date: 2020-05-28 words: 527 flesch: 30 summary: However, heparin is considered an integral part of Covid-19 treatment and essential in critically ill patients at the risk of DIC. • In conclusion, although major bleeding seems to be rare in Covid-19 patients, its management is complex for several reasons: the need to continue anticoagulation, shortage of blood products, multiple sites of haemorrhage and logistic issues. keywords: covid-19; patients cache: cord-260083-c1r9zn43.txt plain text: cord-260083-c1r9zn43.txt item: #801 of 2876 id: cord-260105-ckh8jp9e author: Ñamendys-Silva, Silvio A title: Respiratory support for patients with COVID-19 infection date: 2020-04-30 words: 382 flesch: 29 summary: Supporting the recommendation of the authors, I would like to add some points in relation to the use of high-flow nasal oxygen therapy and non-invasive ventilation in patients with COVID-19 infection: 2 Non-invasive ventilation is not recommended for patients with viral infections complicated by pneumonia because, although non-invasive ventilation temporarily improves oxygenation and reduces the work of breathing in these patients, this method does not necessarily change the natural disease course. keywords: patients; ventilation cache: cord-260105-ckh8jp9e.txt plain text: cord-260105-ckh8jp9e.txt item: #802 of 2876 id: cord-260119-pgu2crhs author: Golledge, Jonathan title: The Potential Role of Sensors, Wearables and Telehealth in the Remote Management of Diabetes-Related Foot Disease date: 2020-08-13 words: 6774 flesch: 38 summary: Given the established effect of leg ischemia on foot temperature and the exclusion of participants with this problem from prior trials [17] [18] [19] [20] 24] , the role of home foot temperature monitoring in people with PAD remains unclear. Recently, a further clinical trial reported on the efficacy of foot temperature monitoring performed at only monthly intervals at an out-patient clinic, rather than at home [24] . keywords: dfd; diabetes; foot; monitoring; patients; people; plantar; pressure; risk; sensors; temperature; trial; ulcers cache: cord-260119-pgu2crhs.txt plain text: cord-260119-pgu2crhs.txt item: #803 of 2876 id: cord-260180-kojb8efv author: Elsoukkary, Sarah S. title: Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience date: 2020-09-17 words: 4616 flesch: 47 summary: A first step in understanding SARS pathogenesis COVID-19 Autopsies Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome : Results From a Prospective, Single-Center Pulmonary Pathology of Early-Phase Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive Postmortem swabs in the Sars-CoV-2 Pandemic: report on 12 complete clinical autopsy cases Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2 SARS-CoV-2 infection in conjunctival tissue -Authors' reply In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19 Postmortem Examination of Patients With COVID-19 Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases SARS-CoV-2-related deaths in routine forensic autopsy practice: histopathological patterns Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study Endorsed by the ISTH, NATF, ESVM, and the IUA, Supported by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function. We report the clinicopathologic findings from 32 autopsy studies conducted on patients who died of COVID-19 including routine gross and microscopic examination with applicable special and immunohistochemical staining techniques. keywords: acute; cases; cells; cov-2; covid-19; disease; injury; patients; sars cache: cord-260180-kojb8efv.txt plain text: cord-260180-kojb8efv.txt item: #804 of 2876 id: cord-260215-gsnjlhjd author: Dhanani, Jayesh title: Fundamentals of aerosol therapy in critical care date: 2016-10-07 words: 8323 flesch: 32 summary: The efficacy of aerosol drug therapy depends on drug-related factors (particle size, molecular weight), device factors, patient-related factors (airway anatomy, inhalation patterns) and mechanical ventilation-related factors (humidification, airway). Figure 2 shows the factors conducive for effective aerosol drug delivery in the critically ill mechanically ventilated and non-mechanically ventilated patient groups. keywords: aerosol; care; delivery; deposition; drug; effect; factors; flow; lung; nebulizers; patients; pneumonia; studies; therapy; use; ventilation cache: cord-260215-gsnjlhjd.txt plain text: cord-260215-gsnjlhjd.txt item: #805 of 2876 id: cord-260224-1aeqe7fh author: Passerini, Matteo title: Disseminated Cryptococcosis in a Patient With Metastatic Prostate Cancer Who Died in the Coronavirus Disease 2019 (COVID-19) Outbreak date: 2020-05-23 words: 2003 flesch: 36 summary: NHNT patients constitute a heterogeneous group that includes patients ranging from seemingly healthy to heavily immunodepressed [5, 6] . Recent studies have shown how the clinical presentation and mortality of this group of patients is different from that of HIV-positive patients, to whom most clinicians are accustomed [6] . keywords: cryptococcosis; infection; patient; therapy; ulcers cache: cord-260224-1aeqe7fh.txt plain text: cord-260224-1aeqe7fh.txt item: #806 of 2876 id: cord-260232-98gtlad6 author: Chenna, Avantika title: Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade date: 2020-06-29 words: 4313 flesch: 48 summary: e patients who tend to have severe disease or need intensive care unit (ICU) admission have multiorgan involvement. e patient was found to be hypoxic in the emergency room, requiring oxygen via a nasal cannula. keywords: ace2; angiotensin; covid-19; daily; e patient; enzyme; mouth; patient cache: cord-260232-98gtlad6.txt plain text: cord-260232-98gtlad6.txt item: #807 of 2876 id: cord-260274-c3586tp6 author: Somers, Emily C title: Tocilizumab for treatment of mechanically ventilated patients with COVID-19 date: 2020-07-11 words: 3655 flesch: 30 summary: Untreated patients who died prior to the opportunity to receive tocilizumab treatment per institutional criteria (within 48 hours of intubation) were excluded to minimize immortal time bias. To address non-randomized treatment allocation, we calculated propensity scores by multivariable logistic regression with tocilizumab treatment as the binary outcome and potential confounding factors associated with both outcome and treatment assignment. keywords: covid-19; il-6; patients; pneumonia; respiratory; study; superinfection; tocilizumab; treatment; ventilation cache: cord-260274-c3586tp6.txt plain text: cord-260274-c3586tp6.txt item: #808 of 2876 id: cord-260456-kjmab3og author: Hegde, Shruti title: Massive Pulmonary Embolism Complicating Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case Report date: 2020-10-28 words: 1861 flesch: 45 summary: A pneumonia outbreak associated with a new coronavirus of probable bat origin Coronavirus COVID-19 Global Multiple enzyme release, inflammation storm and hypercoagulability Are Prominent Indicators For disease Progression In COVID-19: a multi-centered, Correlation Study with CT imaging score Regional right ventricular dysfunction detected by echocardiography in acute pulmonary embolism Clinical characteristics of coronavirus disease 2019 in China Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical and coagulation characteristics of 7 patients with critical COVID-2019 pneumonia and acro-ischemia Findings of acute pulmonary embolism in COVID-19 patients (3) Critical care bedside echocardiography along with other clinical indicators helps in timely diagnosis and thus treatment of APE in patients with COVID-19 pneumonia, which is lifesaving. keywords: ape; case; clinical; covid-19; patients; pneumonia cache: cord-260456-kjmab3og.txt plain text: cord-260456-kjmab3og.txt item: #809 of 2876 id: cord-260503-yq4dtf8n author: SAMARANAYAKE, LAKSHMAN P. title: Severe acute respiratory syndrome and dentistry A retrospective view date: 2004-09-30 words: 6841 flesch: 51 summary: The following are general criteria for laboratory confirmation of SARS-CoV: dDetection of serum antibody to SARS-CoV by a test validated by the Centers for Disease Control and Prevention, or CDC (for example, enzyme immunoassay); or dIsolation in cell culture of SARS-CoV from a clinical specimen; or dDetection of SARS-CoV RNA by a reverse transcriptase polymerase chain reaction test validated by CDC and with subsequent confirmation in a reference laboratory (for example, CDC) dProbable case: meets the clinical criteria for severe respiratory illness of unknown etiology and epidemiologic criteria for exposure; laboratory criteria confirmed or undetermined dSuspect case: meets the clinical criteria for moderate respiratory illness of unknown etiology and epidemiologic criteria for exposure; laboratory criteria confirmed or undetermined A case may be excluded as a suspect or probable SARS case if: dAn alternative diagnosis can fully explain the illness; dThe case has a convalescent-phase serum sample (that is, obtained > 28 days after symptom onset), which is negative for antibodies to SARS-CoV; dThe case was reported on the basis of contact with an index case that was subsequently excluded as a case of SARS, provided other possible epidemiologic exposure criteria are not present * Adapted from the Centers for Disease Control and Prevention. 260503 cord_uid: yq4dtf8n ABSTRACT Background Severe acute respiratory syndrome, or SARS, which has created panic in Asia and in some parts of North America, is the first epidemic of the new century. keywords: care; control; coronavirus; cov; dental; disease; hand; health; infection; patients; sars; transmission; virus cache: cord-260503-yq4dtf8n.txt plain text: cord-260503-yq4dtf8n.txt item: #810 of 2876 id: cord-260525-bohv78hi author: Mei, Yang title: Risk stratification of hospitalized COVID-19 patients through comparative studies of laboratory results with influenza date: 2020-07-31 words: 4178 flesch: 45 summary: In this study, we compared the laboratory manifestations of COVID-19 patients admitted to Northwestern Medicine Health System and compared these findings to a cohort of influenza patients. However, COVID-19 patients dropped more rapidly and plummeted to the same levels as influenza patients in the later stages of disease course. keywords: blood; clusters; covid-19; data; influenza; laboratory; parameters; patients cache: cord-260525-bohv78hi.txt plain text: cord-260525-bohv78hi.txt item: #811 of 2876 id: cord-260605-smkr7b15 author: Vestby, Lene K. title: Bacterial Biofilm and its Role in the Pathogenesis of Disease date: 2020-02-03 words: 12146 flesch: 35 summary: Mucoid colonies are only found in patients with chronic biofilm infection and alginate from mucoid colonies is therefore a biofilm-specific antigen. Mucoid colonies are only found in patients with chronic biofilm infection and alginate from mucoid colonies is therefore a biofilm-specific antigen. keywords: associated; aureus; bacteria; biofilm; cells; chronic; disease; formation; infections; mastitis; media; microscopy; model; otitis; pathogenesis; patients; presence; studies cache: cord-260605-smkr7b15.txt plain text: cord-260605-smkr7b15.txt item: #812 of 2876 id: cord-260630-vvpzp73r author: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 words: 2627 flesch: 48 summary: A case-control study of acute respiratory tract infection in general practice patients in The Netherlands Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease Epidemiology of viral respiratory infections Coronavirus as a possible cause of severe acute respiratory syndrome A novel coronavirus associated with severe acute respiratory syndrome Virologic studies of acute respiratory disease in young adults. key: cord-260630-vvpzp73r authors: Mandell, Lionel A. title: Etiologies of Acute Respiratory Tract Infections date: 2005-08-15 journal: Clin Infect Dis DOI: 10.1086/432019 sha: doc_id: 260630 cord_uid: vvpzp73r nan In this issue of Clinical Infectious Diseases, there are 2 articles that provide us with some insight into the various etiologic agents that can cause acute respiratory tract infection (ARTI) in general practice patients in The Netherlands [1] and into the significance of the human metapneumovirus (hMPV) in patients with community-acquired pneumonia (CAP) and exacerbations of chronic obstructive pulmonary disease (COPD) in Quebec, Canada keywords: hmpv; infection; pathogens; patients; study; subjects cache: cord-260630-vvpzp73r.txt plain text: cord-260630-vvpzp73r.txt item: #813 of 2876 id: cord-260679-tm1s6wvj author: Lim, Wei Shen title: Pneumonia—Overview date: 2020-05-20 words: 6882 flesch: 35 summary: A systematic review Peto TE, and Infections in Oxfordshire Research Database (IORD) (2016) Increasing burden of community-acquired pneumonia leading to hospitalisation Corticosteroids in sepsis: An updated systematic review and meta-analysis Mortality reduction among pneumonia patients still substantial despite the impact of coding changes Host-response biomarkers for the diagnosis of bacterial respiratory tract infections Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections HIV-1 and bacterial pneumonia in the era of antiretroviral therapy Diagnosis of pneumonia in the ED has poor accuracy despite diagnostic uncertainty Alcohol and the risk of pneumonia: Pneumococcal pneumonia caused 55% of LRI deaths in all ages (1.5 million deaths). keywords: cap; diagnosis; hospital; immune; incidence; infection; mortality; pathogens; patients; pneumonia; risk; treatment cache: cord-260679-tm1s6wvj.txt plain text: cord-260679-tm1s6wvj.txt item: #814 of 2876 id: cord-260700-u12aa739 author: Kainulainen, Leena title: Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia date: 2010-06-10 words: 3695 flesch: 43 summary: The occurrence of respiratory tract viral infections in patients with primary hypogammaglobulinemia has not been studied. Despite adequate immunoglobulin replacement therapy, patients with primary hypogammaglobulinemia have increased susceptibility to respiratory tract viral infections. keywords: hypogammaglobulinemia; infections; nasal; patients; respiratory; rhinoviral; sputum; tract; viruses cache: cord-260700-u12aa739.txt plain text: cord-260700-u12aa739.txt item: #815 of 2876 id: cord-260762-1kuj5dzz author: Elledge, Christen R. title: Radiation therapy for gynecologic malignancies during the COVID-19 pandemic: International expert consensus recommendations date: 2020-06-15 words: 3973 flesch: 30 summary: Additionally, cancer patients may have an increased risk of contracting the virus or difficulty clearing the virus once infected due to their immunocompromised state. Two independent studies have reported a greater risk of severe events (ICU admission, mechanical ventilation, and death) secondary to COVID-19 in cancer patients compared to patients without cancer in China. keywords: cancer; consensus; covid-19; patients; radiation; recommendations; therapy; treatment cache: cord-260762-1kuj5dzz.txt plain text: cord-260762-1kuj5dzz.txt item: #816 of 2876 id: cord-260854-v7wgb6mr author: Colafrancesco, Serena title: COVID-19 gone bad: A new character in the spectrum of the hyperferritinemic syndrome? date: 2020-05-05 words: 3342 flesch: 27 summary: A significant amount of COVID-19 patients is currently experiencing severe interstitial pneumonia possibly ending up with acute respiratory distress syndrome (ARDS) and systemic inflammatory response syndrome (SIRS). However, as noted by Mc Gonagle D and coll, the increased vascular coagulation occurring in COVID-19 patients is more close to a lung centric pulmonary intravascular coagulopathy (PIC) rather than a classical DIC keywords: coronavirus; covid-19; disease; ferritin; inflammation; inflammatory; patients; sars; syndrome cache: cord-260854-v7wgb6mr.txt plain text: cord-260854-v7wgb6mr.txt item: #817 of 2876 id: cord-260857-oxxle915 author: Samuel, Sharmeen title: INCIDENCE OF ARRHYTHMIAS AND ELECTROCARDIOGRAPHIC ABNORMALITIES IN SYMPTOMATIC PEDIATRIC PATIENTS WITH PCR POSITIVE SARS-CoV-2 INFECTION INCLUDING DRUG INDUCED CHANGES IN THE CORRECTED QT INTERVAL (QTc). date: 2020-07-01 words: 4188 flesch: 40 summary: There are several main findings of this paper including the following:1) significant arrhythmias in pediatric patients with COVID-19 infection are infrequent but occur at incidence higher than expected in a general pediatric population, 2) comorbidities are not more common in COVID-19 patients with arrhythmias. The Lancet Cardiac involvement in COVID-19 patients: Risk factors, predictors, and complications: A review Cardiac Arrhythmias in COVID-19 Infection Guidance for Cardiac Electrophysiology During the Coronavirus (COVID-19) Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology Drug-induced ventricular tachycardia Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. keywords: arrhythmias; covid-19; hcq; patients; qtc; study; treatment cache: cord-260857-oxxle915.txt plain text: cord-260857-oxxle915.txt item: #818 of 2876 id: cord-260871-dtn5t8ka author: Silva, Marcus Tulius T. title: SARS-CoV-2: Should We Be Concerned about the Nervous System? date: 2020-07-17 words: 4122 flesch: 36 summary: [39] Typically, SARS patients exhibited a triphasic pattern of disease, initially presenting with fever, a nonproductive cough, sore throat, and myalgia. A novel syndrome Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study Entry of coronavirus into primate CNS following peripheral infection SARS-associated coronavirus Coronavirus pathogenesis Renin-angiotensin-aldosterone system inhibitors in patients with COVID-19 Angiotensin-converting enzyme 2 in the brain: properties and future directions Epidemiological and clinical features of human coronavirus infections among different subsets of patients Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method Detection of the human coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients Murine hepatitis virus-a model for virus-induced CNS demyelination Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human Phylogeny of the SARS coronavirus The genome sequence of the SARSassociated coronavirus Characterization of a novel coronavirus associated with severe acute respiratory syndrome The severe acute respiratory syndrome Severe acute respiratory syndrome and critical care medicine: the Toronto experience Olfactory neuropathy in severe acute respiratory syndrome: report of a case Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome Pathological findings of COVID-19 associated with acute respiratory distress syndrome Multiple organ infection and the pathogenesis of SARS Persistence of physical symptoms in and abnormal laboratory findings for survivors of severe acute respiratory syndrome Hypocortisolism in survivors of severe acute respiratory syndrome (SARS) Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A pneumonia outbreak associated with a new coronavirus of probable bat origin Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms The vagus nerve is one route of transneural invasion for intranasally inoculated influenza A virus in mice CNS innervation of vagal preganglionic neurons controlling peripheral airways: a transneuronal labeling study using pseudorabies virus Middle east respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis A first case of meningitis/encephalitis associated with SARS-coronavirus-2 COVID-19: consider cytokine storm syndromes and immunosuppression Guillain-barré syndrome associated with SARS-CoV-2 Miller fisher syndrome and polyneuritis cranialis in COVID-19 Pearls and oysters: facial nerve palsy as a neurological manifestation of COVID-19 infection Neurologic features in severe SARS-CoV-2 infection Large-vessel stroke as a presenting feature of COVID-19 in the young COVID-19 and its implications for thrombosis and anticoagulation D-dimer levels on admission to predict in-hospital mortality in patients with COVID-19 Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the central nervous system Neurologic alterations due to respiratory virus infections keywords: acute; coronavirus; cov; cov-2; covid-19; human; infection; patients; sars; syndrome cache: cord-260871-dtn5t8ka.txt plain text: cord-260871-dtn5t8ka.txt item: #819 of 2876 id: cord-260980-tyf3fuz9 author: Lorenzo Villalba, Noel title: Anosmia and Dysgeusia in the Absence of Other Respiratory Diseases: Should COVID-19 Infection Be Considered? date: 2020-04-03 words: 1217 flesch: 48 summary: He lived with his wife and there was apparently no close contact with anybody with acute respiratory symptoms. Anosmia, hyposmia and dysgeusia in the absence of other respiratory diseases such as allergic rhinitis, acute rhinosinusitis or chronic rhinosinusitis, should alert physicians to the possibility of COVID-19 infection and prompt serious consideration of self-isolation and testing of these individuals. keywords: anosmia; covid-19; patients; symptoms cache: cord-260980-tyf3fuz9.txt plain text: cord-260980-tyf3fuz9.txt item: #820 of 2876 id: cord-260981-647wfa8z author: Torti, Lorenza title: Impact of SARS CoV-2 in Hemoglobinopathies with Immune Disfunction and Epidemiology. A Protective Mechanism from Beta Chain Hemoglobin Defects? date: 2020-07-01 words: 1294 flesch: 47 summary: We report here a case of SARS-CoV-2 infection in a thalassemic patient and the effects of the local outbreak in hemoglobinopathic patients which have a higher incidence of infections due to abnormalities both of innate and adaptive immunity. The role of ORF viral proteins, essential both in viral replication and inflammation, and the interaction with the BCH and porphyrins might be one of the links to the epidemiologic distribution and mortality among hemoglobinopathic patients? keywords: covid-19; patients; sars cache: cord-260981-647wfa8z.txt plain text: cord-260981-647wfa8z.txt item: #821 of 2876 id: cord-261006-2xh3f07i author: Dong, Zhiyong title: Recommendations to Manage Patients for Bariatric Surgery in the COVID-19 Pandemic: Experience from China date: 2020-06-06 words: 1367 flesch: 40 summary: key: cord-261006-2xh3f07i authors: Dong, Zhiyong; Zhang, Peng; Zhu, Jiangfan; Bai, Jie; Parmar, Chetan; Chen, Wenhui; Hu, Ruixiang; Wang, Jianxue; Chong, Tsz Hong; Jiang, Shuwen; Yang, Wah; Gao, Lilian; Chen, Xiaomei; Yang, Jingge; Xia, Zefeng; Tao, Kaixiong; Wang, Cunchuan title: Recommendations to Manage Patients for Bariatric Surgery in the COVID-19 Pandemic: Experience from China date: 2020-06-06 journal: Obes Surg DOI: 10.1007/s11695-020-04741-8 sha: doc_id: 261006 cord_uid: 2xh3f07i nan In our bariatric surgery department, we stopped elective bariatric surgeries in January to prepare for a possible influx of COVID-19 patients. Novel coronavirus (COVID-19) situation dashboard Obesity, fat mass and immune system: role for leptin Impact of obesity on influenza A virus pathogenesis, immune response, and evolution Minimally invasive surgery and the novel coronavirus outbreak: lessons learned in China and Italy Practical recommendations of the obesity management task force of the European Association for the Study of obesity for the post-bariatric surgery medical management ASMBS pediatric metabolic and bariatric surgery guidelines Nutritional recommendations for adult bariatric surgery patients: clinical practice A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) Factors associated with mental health outcomes among health care workers exposed to coronavirus disease 2019 Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations keywords: covid-19; health; infection; patients; surgery cache: cord-261006-2xh3f07i.txt plain text: cord-261006-2xh3f07i.txt item: #822 of 2876 id: cord-261025-y49su5uc author: Sampathkumar, Priya title: SARS: Epidemiology, Clinical Presentation, Management, and Infection Control Measures date: 2003-07-31 words: 3955 flesch: 46 summary: Specific instructions for collecting specimens from suspected SARS patients are available from the CDC. In all series of SARS cases described to date, therapy has involved broad-spectrum antibiotics, including a fluoroquinolone or macrolide. keywords: disease; fever; health; patients; sars; severe; symptoms; syndrome; transmission cache: cord-261025-y49su5uc.txt plain text: cord-261025-y49su5uc.txt item: #823 of 2876 id: cord-261062-9zhe3ejy author: Zhu, Shu-Ting title: Utility of Point-of-Care Lung Ultrasound for Clinical Classification of COVID-19 date: 2020-09-21 words: 2748 flesch: 45 summary: This kind of classification of LUS scores can effectively stratify COVID-19 pneumonia severity and helpfully guide clinical monitoring. There were dramatic differences in LUS (p<0.001) among the three groups, and LUS scores (r=0.754) correlated positively with clinical severity (p<0.01). keywords: covid-19; lung; lus; patients; study cache: cord-261062-9zhe3ejy.txt plain text: cord-261062-9zhe3ejy.txt item: #824 of 2876 id: cord-261151-27ocvgnw author: Becker, Jessica E. title: Pediatric Consultation-Liaison Psychiatry: An Update and Review date: 2020-04-25 words: 8050 flesch: 24 summary: EDs are generally not equipped to handle longer-stay patients and often do not have the same support services that medical pediatrics floors may have, such as Child Life or Occupational Therapy services; 56 as a result, increasing numbers of pediatric psychiatric patients are being admitted to board on inpatient pediatric floors to await psychiatric placement. Recent consensus guidelines for pediatric psychiatric patients in the ED may serve as a reference for agitation contingency planning once patients become boarders; these guidelines suggest non-pharmacologic de-escalation techniques, such as verbal and behavioral de-escalation, as a first-line for agitation in children, followed by medication interventions ranging from diphenhydramine, lorazepam, and clonidine to atypical antipsychotic medications. keywords: care; children; consultation; delirium; disorder; health; hospital; inpatient; management; patients; pediatric; psychiatric; review; setting; symptoms; treatment cache: cord-261151-27ocvgnw.txt plain text: cord-261151-27ocvgnw.txt item: #825 of 2876 id: cord-261240-osbk041e author: Bermejo-Martin, Jesús F title: Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection date: 2020-03-05 words: 971 flesch: 37 summary: The existence of hyper-cytokinemia in COVID-19 patients with lymphopenia could indicate a poor control of the pathogen, as showed in severe patients infected with the 2009 Pandemic Influenza virus. As we recently reviewed in J Clin Med, endothelial dysfunction induces disassembly of intercellular junctions, endothelial cell death and blood-tissue barrier disruption, along with enhanced leukocyte adhesion and extravasation, which could contribute to explain the lymphopenia observed in severe COVID-19 patients [9] . keywords: covid-19; lymphopenia; patients cache: cord-261240-osbk041e.txt plain text: cord-261240-osbk041e.txt item: #826 of 2876 id: cord-261246-m40kwgcg author: Chen, Nanshan title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study date: 2020-01-30 words: 4019 flesch: 51 summary: Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). keywords: china; clinical; coronavirus; data; infection; ncov; patients; pneumonia; study; wuhan cache: cord-261246-m40kwgcg.txt plain text: cord-261246-m40kwgcg.txt item: #827 of 2876 id: cord-261311-j6bmgmhz author: Parreiras Martins, Maria Auxiliadora title: Preparedness of pharmacists to respond to the emergency of the COVID-19 pandemic in Brazil: a comprehensive overview date: 2020-07-31 words: 4312 flesch: 32 summary: Rev Bras Ter Intensiva Liver and kidney injuries in COVID-19 and their effects on drug therapy; a letter to editor COVID-19 and older adults: what we know New understanding of the damage of SARS-CoV-2 infection outside the respiratory system Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy A proposal for staging COVID-19 coagulopathy Heparin: effects upon the glycocalyx and endothelial cells The versatile heparin in COVID-19 Stratifying therapeutic enoxaparin dose in morbidly obese patients by BMI class: a retrospective cohort study Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: a statement from the Canadian Heart Rhythm Society Antibiotic use in the intensive care unit: optimization and de-escalation COVID-19: the uninvited guest in the intensive care unit (ICU) implications for pharmacotherapy COVID-19 and the potential long-term impact on antimicrobial resistance Involving antimicrobial stewardship programs in COVID-19 response efforts: all hands on deck Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know Hyperinflammatory shock in children during COVID-19 pandemic Breastfeeding and respiratory antivirals: coronavirus and influenza COVID-19 and cancer: a comprehensive review A standardized, structured approach to identifying drug-related problems in the intensive care unit: FASTHUG-MAIDENS Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Prediction models for diagnosis and prognosis of COVID-19 infection: systematic review and critical appraisal The laboratory tests and host immunity of COVID-19 patients with different severity of illness Development and validation of a clinical risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19 Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease COVID19 coagulopathy in Caucasian patients Atrial fibrillation: prevalence in a large database of primary care patients in Brazil Acknowledgements COVID-19 patients may present high risk in the use of medications and clinical pharmacists can contribute substantially as part of a multidisciplinary team to improve outcomes in drug therapy in severe and critical illness. keywords: brazil; care; coronavirus; covid-19; disease; drug; health; pandemic; patients; pharmacists; pharmacy; use cache: cord-261311-j6bmgmhz.txt plain text: cord-261311-j6bmgmhz.txt item: #828 of 2876 id: cord-261380-xms5su6w author: Rahmani, Hamid title: Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date: 2020-08-24 words: 2780 flesch: 46 summary: Patients in the IFN group received IFN β-1b (250 mcg subcutaneously every other day for two consecutive weeks) along with the national protocol medications while in the control group, patients received only the national protocol medications (lopinavir/ritonavir or atazanavir/ritonavir plus hydroxychloroquine for 7-10 days). Patients in the IFN group received IFN β-1b along with the national protocol medications, while in the control group, patients received only the national protocol medications. keywords: control; covid-19; group; ifn; patients; treatment; β-1b cache: cord-261380-xms5su6w.txt plain text: cord-261380-xms5su6w.txt item: #829 of 2876 id: cord-261383-izd1vn6f author: Oleynick, Christopher title: Symptoms of Pleurisy as the Initial Presentation of COVID-19 date: 2020-07-24 words: 2035 flesch: 47 summary: CONCLUSIONS: I report a patient who experienced pleuritic chest pain from viral pleurisy that was the initial manifestation of COVID-19 which, to the best of my knowledge, has not yet been reported in the literature. I report a patient who experienced pleuritic chest pain as the initial manifestation of infection with COVID-19, who subsequently developed more typical features, including cough, fever, shortness of breath, and hypoxia. keywords: chest; covid-19; pain; patient; scan cache: cord-261383-izd1vn6f.txt plain text: cord-261383-izd1vn6f.txt item: #830 of 2876 id: cord-261410-kb91eagd author: Park, Ji Young title: Clinical Features and Courses of Adenovirus Pneumonia in Healthy Young Adults during an Outbreak among Korean Military Personnel date: 2017-01-23 words: 3512 flesch: 41 summary: Only 12% of HAdV pneumonia patients displayed leukocytosis, whereas febrile leukopenia (62.7%) and thrombocytopenia (41%) were commonly observed. Fever, high fever (!39.0˚C), nasal congestion, sore throat, throat clearing, headache, and pharyngeal inflammation were more common among HAdV pneumonia patients than in others. keywords: adenovirus; group; hadv; infection; military; outbreak; patients; pneumonia; training cache: cord-261410-kb91eagd.txt plain text: cord-261410-kb91eagd.txt item: #831 of 2876 id: cord-261455-uejtwgar author: Roschewski, Mark title: Inhibition of Bruton tyrosine kinase in patients with severe COVID-19 date: 2020-06-05 words: 7687 flesch: 33 summary: It has been reported that COVID-19 patients can have a biphasic clinical course with deterioration following initial improvement, consistent with a delayed and exaggerated immune activation (2) (3) (4) . We next examined expression of IL-6 protein by immune cells in the blood of COVID-19 patient since the production of this cytokine is known to be increased by BTK activity in normal human monocytes/macrophages (Fig. S2 ). keywords: acalabrutinib; activation; blood; btk; cells; clinical; cohort; covid-19; il-6; monocytes; oxygen; patients; table; treatment; ventilation cache: cord-261455-uejtwgar.txt plain text: cord-261455-uejtwgar.txt item: #832 of 2876 id: cord-261470-sqxdwu6j author: Weichmann, Franziska title: Projected supportive effects of Pycnogenol® in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection date: 2020-10-09 words: 5931 flesch: 30 summary: We propose that Pycnogenol® may be beneficial in supporting recovery and mitigating symptoms and long-term consequences resulting from a SARS-CoV2 infection in COVID-19 patients. This property of Pycnogenol ® should be helpful in COVID-19 patients as well. keywords: cells; clinical; coronavirus; cov2; covid-19; disease; effects; infection; patients; pycnogenol; sars; study; syndrome cache: cord-261470-sqxdwu6j.txt plain text: cord-261470-sqxdwu6j.txt item: #833 of 2876 id: cord-261485-0ke5nqy0 author: Sabir, A. M. title: Effects of Anticoagulants and Corticosteroids therapy in patients affected by severe COVID-19 Pneumonia date: 2020-06-29 words: 4666 flesch: 52 summary: It was also observed that severe COVID-19 patients had higher levels of IL-6, 18 , suggesting that the hypercoagulation status of COVID-19 patients may be related to the elevated levels of cytokines. Therefore, COVID-19 patients with exertional dyspnea with or without hypoxia should be admitted to hospitals, evaluated for pulmonary involvement clinically and radiologically, and treated early with anti-inflammatory and antiviral drugs. keywords: covid-19; days; oxygen; patients; pneumonia; preprint; treatment cache: cord-261485-0ke5nqy0.txt plain text: cord-261485-0ke5nqy0.txt item: #834 of 2876 id: cord-261670-rd9uq6tc author: Stringer, Kathleen A. title: COVID‐19: The Uninvited Guest in the Intensive Care Unit — Implications for Pharmacotherapy date: 2020-05-04 words: 2886 flesch: 34 summary: 16 They collectively recommend that these therapies neither be withheld nor added in COVID-19 patients based on lack of human data and preclinical data suggesting benefit from their use. Larger hospitals are also establishing dedicated respiratory infectious containment units specifically for the treatment of COVID-19 patients regardless of whether they require mechanical ventilation. keywords: china; clinical; covid-19; patients; studies; treatment; use cache: cord-261670-rd9uq6tc.txt plain text: cord-261670-rd9uq6tc.txt item: #835 of 2876 id: cord-261736-jlwctmxw author: Marchand, Geneviève title: Bacteria emitted in ambient air during bronchoscopy—a risk to health care workers? date: 2016-12-01 words: 3528 flesch: 42 summary: It provides clear evidence of the presence of culturable opportunistic bacteria originating from the respiratory tract of patients in the air of bronchoscopy rooms. Ottawa (ON): Public Health Agency of Canada Helicobacter pylori prevalence in endoscopy and medical staff Occupationally acquired infections in health care workers: part II Nosocomial tuberculosis 1, 2 Occupationally acquired infections in health care workers: part I Cough frequency and infectivity in patients with pulmonary tuberculosis 1 Occupational tuberculous infections among pulmonary physicians in training Coughgenerated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness Quantity and size distribution of cough-generated aerosol particles produced by influenza patients during and after illness Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis Airborne transmission of disease in hospitals Understanding the symptoms of the common cold and influenza Global physiology and pathophysiology of cough: ACCP evidencebased clinical practice guidelines Protecting the faces of health care workers: knowledge gaps and research priorities for effective protection against occupationally-acquired respiratory infectious diseases Toward understanding the risk of secondary airborne infection: emission of respirable pathogens A review of the risks and disease transmission associated with aerosol generating medical procedures Evaluation of eight bioaerosol samplers challenged with Aerosolof free bacteria New sampler for the collection, sizing, and enumeration of viable airborne particles Identification of bacteria by gas chromatography of cellular fatty acids Preliminary evaluation of Biolog, a carbon source utilization method for bacterial identification Multiplex PCR assay for immediate identification of the infecting species in patients with mycobacterial disease Evaluation of three influenza A and B real-time reverse transcription-PCR assays and a new 2009 H1N1 assay for detection of influenza viruses World Health Organization. keywords: air; bacteria; bronchoscopy; concentrations; hcws; patients; procedures; risk; room; study cache: cord-261736-jlwctmxw.txt plain text: cord-261736-jlwctmxw.txt item: #836 of 2876 id: cord-261801-va2e029z author: Hoffman, Pamela E. title: Rapidly scaling video visits during COVID-19: The ethos of virtual care at Yale Medicine date: 2020-10-01 words: 1373 flesch: 31 summary: Lesson 2: While resistance to change was the norm, the COVID-19 crisis motivated improvements to four major internal operational workflows (scheduling, appointment conversions, patient support and Virtual Rooming Assistants) for video visits, which were met with acceptance by both clinical and non-clinical staff. 21 22 • Lesson 2: While resistance to change was the norm, the COVID-19 crisis motivated 23 improvements to four major internal operational workflows (scheduling, appointment 24 conversions, patient support and Virtual Rooming Assistants) for video visits, which 25 were met with acceptance by both clinical and non-clinical staff. keywords: lesson; patient; telehealth; visits cache: cord-261801-va2e029z.txt plain text: cord-261801-va2e029z.txt item: #837 of 2876 id: cord-261856-i1e0uj0s author: Heffner, John E title: Chronic obstructive pulmonary disease in geriatric critical care date: 2005-03-04 words: 4818 flesch: 32 summary: A model analysis in the netherlands The evidence base for management of acute exacerbations of COPD: clinical practice guideline, part 1 Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease Toward a consensus definition for COPD exacerbations Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations Airway eosinophilia in chronic bronchitis during exacerbations Airway eosinophilia and expression of interleukin-5 protein in asthma and in exacerbations of chronic bronchitis Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD Air pollution and daily admissions for chronic obstructive pulmonary disease in 6 European cities: results from the APHEA project Effect of temperature on lung function and symptoms in chronic obstructive pulmonary disease Randomized, doubleblind study of ciprofloxacin and cefuroxime axetil for treatment of acute bacterial exacerbations of chronic bronchitis. key: cord-261856-i1e0uj0s authors: Heffner, John E; Highland, Kristin B title: Chronic obstructive pulmonary disease in geriatric critical care date: 2005-03-04 journal: Crit Care Clin DOI: 10.1016/s0749-0704(03)00054-x sha: doc_id: 261856 cord_uid: i1e0uj0s COPD is a progressive disorder that is punctuated in its later stages with acute exacerbations that present a risk for respiratory failure. keywords: airway; care; chronic; copd; disease; exacerbations; failure; life; lung; patients; ventilation cache: cord-261856-i1e0uj0s.txt plain text: cord-261856-i1e0uj0s.txt item: #838 of 2876 id: cord-261921-c97ygxq2 author: Souders, Colby P. title: Considerations for Bedside Urologic Procedures in Patients with Severe Acute Respiratory Syndrome Coronavirus-2 date: 2020-04-24 words: 1827 flesch: 37 summary: key: cord-261921-c97ygxq2 authors: Souders, Colby P.; Zhao, Hanson; Ackerman, A. Lenore title: Considerations for Bedside Urologic Procedures in Patients with Severe Acute Respiratory Syndrome Coronavirus-2 date: 2020-04-24 journal: Urology DOI: 10.1016/j.urology.2020.04.066 sha: doc_id: 261921 cord_uid: c97ygxq2 OBJECTIVE: To provide guidance when performing bedside urologic procedures on SARS-CoV-2 positive patients and offer considerations to maximize the safety of the patients and providers, conserve supplies, and provide optimal management of urologic issues. For patients who require an exam or procedure, the history and any procedural consent can be obtained prior to intervention to reduce the duration of potential exposure (for both provider and patient) and minimize the usage of personal protective equipment (PPE). keywords: bedside; cov-2; patients; sars cache: cord-261921-c97ygxq2.txt plain text: cord-261921-c97ygxq2.txt item: #839 of 2876 id: cord-261941-xf1k5uj1 author: Stackhouse, Robin A. title: Severe acute respiratory syndrome and tuberculosis date: 2005-03-01 words: 5425 flesch: 52 summary: SARS patients should only be outside their room for required medical procedures. Many workers in the markets of southern China have tested positive for SARS-CoV antibody (40% wild animal traders, 20% wild animal butchers, 5% vegetable traders) without ever having evidence of SARS infection keywords: acute; contact; control; disease; health; infection; patient; room; sars; syndrome; treatment cache: cord-261941-xf1k5uj1.txt plain text: cord-261941-xf1k5uj1.txt item: #840 of 2876 id: cord-261980-bm0benu2 author: Cox, Mougnyan title: Neuroendovascular Treatment of Acute Stroke during Covid-19: A Guide from the Frontlines date: 2020-05-29 words: 2756 flesch: 42 summary: This especially evident during the COVID-19 pandemic, a situation that has increased the demands on radiology nurses during neurointervention for stroke patients of unknown COVID-19 status (so-called patients under investigation for COVID-19 or PUI). In addition, our modified protocols for resource utilization and management of stroke patients with LVO were also reviewed and clarified. keywords: acute; care; covid-19; patients; room; stroke; thrombectomy cache: cord-261980-bm0benu2.txt plain text: cord-261980-bm0benu2.txt item: #841 of 2876 id: cord-262068-9ixq8hwb author: Gottardi, Andrea De title: Clinical characteristics and management of a liver transplanted patient admitted with SARS-CoV-2 infection date: 2020-06-10 words: 1782 flesch: 42 summary: Therefore, due to the potential clinical efficacy for COVID-19 patients [11] and based on SARS clinical cases in 2003 [12] , and before the publication of the LOTUS China trial [13] , we started a treatment with lopinavir 200 mg and ritonavir 50 mg 2-0-2, and hydroxychloroquine 200 mg twice daily. We discussed the option of starting a treatment with tocilizumab, an interleukin-6 inhibitor, in the case of worsening of the symptoms, although there is no efficacy or safety data yet to support its use in COVID-19 patients. keywords: infection; liver; patient; sars; treatment cache: cord-262068-9ixq8hwb.txt plain text: cord-262068-9ixq8hwb.txt item: #842 of 2876 id: cord-262150-j72jbohi author: Cheng, Chun-Hung title: RFID analytics for hospital ward management date: 2015-10-23 words: 7600 flesch: 43 summary: McKinsey & Company RFID-enabled process reengineering of closed-loop supply chains in the healthcare industry of Singapore Contributions to radio frequency identification (RFID) research: an assessment of SCI-, SSCI-indexed papers from A healthcare integration system for disease assessment and safety monitoring of dementia patients Novel technique radio frequency identification (RFID) based to manage patient flow in a radiotherapy department Accuracy of patients turnover time prediction using RFID technology in an academic ambulatory surgery center Using RFID technologies to capture simulation data in a hospital emergency department The adoption of RFID in fashion retailing: a business value-added framework Active RFID system augmented with 2D barcode for asset management in a hospital setting RFID technology and applications in production and supply chain management RFID: technology, applications, and impact on business operations RFID research: an academic literature review (1995-2005) and future research directions Evaluation of an infrared/radiofrequency equipment-tracking system in a tertiary care hospital Introducing RFID technology in dynamic and timecritical medical settings: requirements and challenges Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Monitoring, control and diagnostics using RFID infrastructure Future impacts of RFID on e-supply chains in grocery retailing Use of radio frequency identification (RFID) tags in bedside monitoring of endotracheal tube position RFID in healthcare: a panacea for the regulations and issues affecting the industry Improving the logistics operations of the hospital pharmacy using a barcode-RFID identification system Radio frequency identification (RFID) in health care: privacy and security concerns limiting adoption A literature review on the impact of RFID technologies on supply chain management Equipment location in hospitals using RFID-based positioning system Strategic value of RFID in supply chain management RFID-enabled healthcare applications, issues and benefits: an archival analysis (1997-2011) A literature review of RFID-enabled healthcare applications and issues Enhancing construction quality inspection and management using RFID technology Summary of probable SARS cases with onset of illness from 1 Health care-associated infections fact sheet Where is my suitcase? RFID and airline customer service Leveraging complex event processing for smart hospitals using RFID The adoption and implementation of RFID technologies in healthcare: a literature review Two RFID-based solutions for secure inpatient medication administration FDA embraces RFID to protect drug supply A review of RFID technology and its managerial applications in different industries keywords: data; equipment; healthcare; hospital; individuals; information; management; patients; platform; rfid; staff; system; time; ward cache: cord-262150-j72jbohi.txt plain text: cord-262150-j72jbohi.txt item: #843 of 2876 id: cord-262236-1lilrqts author: Capone, Stephen title: Characterization of Critically Ill COVID-19 Patients at a Brooklyn Safety-Net Hospital date: 2020-08-17 words: 3449 flesch: 38 summary: We suggest that the efficacy of anticoagulation may correlate to the increased incidence of thrombotic events seen in COVID-19 patients, which have the potential to lead to major sequelae, including organ failure and potentially death Although there has been significant speculation that individual medical comorbidities may impact the outcomes of COVID-19 patients, we have been unable to identify any significant individual factor. keywords: comorbidities; covid-19; median; mortality; patients; survival cache: cord-262236-1lilrqts.txt plain text: cord-262236-1lilrqts.txt item: #844 of 2876 id: cord-262339-e2ayh108 author: Bohner, Lauren title: 2019-nCoV: Measures Adopted at the Departments of Oral Surgery and Radiology during the Period of an Uncontrolled Transmission Increase date: 2020-06-08 words: 1674 flesch: 52 summary: Emergency treatments of infected patients should be performed, when possible, in an isolated dental office. When treating infected patients, the use of a special mask, FFP-2 or FFP-3, is strongly recommended [7] [8] [9] . keywords: measures; ncov; patients; use cache: cord-262339-e2ayh108.txt plain text: cord-262339-e2ayh108.txt item: #845 of 2876 id: cord-262412-bs7quwov author: Kaya, Gürkan title: Clinical and Histopathological Features and Potential Pathological Mechanisms of Skin Lesions in COVID-19: Review of the Literature date: 2020-06-30 words: 3365 flesch: 24 summary: In a recent report, the postmortem histology of COVID-19 patients revealed lymphocytic endotheliitis in lung, heart, kidney, liver and small intestine, a pathological picture reminiscent of what is seen in skin lesions, suggesting that SARS-CoV-2 infection facilitates the induction of endothelial inflammation in several organs as a direct consequence of viral involvement and of host inflammatory response [61] . The pathological mechanisms of skin lesions in COVID-19 patients remain poorly understood. keywords: cov-2; covid-19; infection; lesions; manifestations; patients; sars; skin cache: cord-262412-bs7quwov.txt plain text: cord-262412-bs7quwov.txt item: #846 of 2876 id: cord-262454-bccrvapy author: Szente Fonseca, Silvia Nunes title: Risk of Hospitalization for Covid-19 Outpatients Treated with Various Drug Regimens in Brazil: Comparative Analysis date: 2020-10-31 words: 4704 flesch: 44 summary: We observed that outpatient hospitalizations of the larger group of suspected COVID-19 ER patients, from the same HMO database before vs after the protocol started, March-April vs May, decreased significantly, 23% vs 9%, and mortality declined from 1.75% to 1.39%. The comorbidity distributions of the various treatments as shown in Table 1 suggest that except for shortness of breath, patients not treated with HCQ or J o u r n a l P r e -p r o o f prednisone may have been slightly less symptomatic than treated patients. keywords: age; covid-19; disease; hcq; medications; patients; risk; treatment; use cache: cord-262454-bccrvapy.txt plain text: cord-262454-bccrvapy.txt item: #847 of 2876 id: cord-262467-epqqd8n8 author: Chen, Jun title: COVID-19 infection: the China and Italy perspectives date: 2020-06-08 words: 7608 flesch: 41 summary: Other symptoms including rhinorrhoea, sore throat, fatigue, dyspnea, muscle weakness, dizziness, and headache are also often reported in COVID-19 patients. As a viral pneumonia, respiratory tract specimens from COVID-19 patients are first of choice to collect for the detection of viral nuclear acid. keywords: cases; china; clinical; coronavirus; cov-2; covid-19; disease; hcq; infection; patients; plasma; sars; study; tests; treatment cache: cord-262467-epqqd8n8.txt plain text: cord-262467-epqqd8n8.txt item: #848 of 2876 id: cord-262518-a2ql8hib author: Fan, Peijin Esther Monica title: Needs and concerns of patients in isolation care units - learnings from COVID-19: A reflection date: 2020-05-26 words: 1919 flesch: 58 summary: WHO Director-General's opening remarks at the media briefing on COVID-19-11 Adverse effects of isolation in hospitalised patients: a systematic review The psychological impact of isolation The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital Contact isolation in surgical patients: a barrier to care? key: cord-262518-a2ql8hib authors: Fan, Peijin Esther Monica; Aloweni, Fazila; Lim, Shu Hui; Ang, Shin Yuh; Perera, Karen; Quek, Aik Huan; Quek, Hwee Koon Susan; Ayre, Tracy Carol title: Needs and concerns of patients in isolation care units - learnings from COVID-19: keywords: covid-19; family; isolation; patients cache: cord-262518-a2ql8hib.txt plain text: cord-262518-a2ql8hib.txt item: #849 of 2876 id: cord-262551-hxhlhb5m author: van der Gronde, Toon title: Toward a New Model of Understanding, Preventing, and Treating Adolescent Depression Focusing on Exhaustion and Stress date: 2020-05-06 words: 5761 flesch: 34 summary: Psychedelic drugs in the treatment of anxiety, depression and addiction Serotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease: A systematic review Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years Psilocybin for treatment-resistant depression: fMRImeasured brain mechanisms Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression Antidepressant actions of ketamine: from molecular mechanisms to clinical practice Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents Esketamine for treatment resistant depression: a trick of smoke and mirrors? Understanding, Preventing, and Treating Adolescent Depression Frontiers in Psychiatry | www Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy IL-6 and depression: A systematic review and meta-analysis of longitudinal studies Inflammatory biomarkers and depression Toward a revised evolutionary adaptationist analysis of depression: the social navigation hypothesis Cognitive bias modification for anxiety: current evidence and future directions From Hans Selye's discovery of biological stress to the identification of corticotropin-releasing factor signaling pathways: implication in stress-related functional bowel diseases What does the legacy of Hans Selye and Franz Alexander mean today? In later years, reduced adult neurogenesis and changes in structural and functional neuronal plasticity have been linked to the onset and treatment opportunities of major depression (10, 11) . keywords: adolescents; behavior; coping; depression; disorder; exhaustion; mood; patients; review; stress; symptoms; treatment cache: cord-262551-hxhlhb5m.txt plain text: cord-262551-hxhlhb5m.txt item: #850 of 2876 id: cord-262626-yk4e737w author: Favaloro, Emmanuel J. title: Recommendations for Minimal Laboratory Testing Panels in Patients with COVID-19: Potential for Prognostic Monitoring date: 2020-04-12 words: 1169 flesch: 33 summary: The rationale for the listing is also provided and based on recent reports around clinical and laboratory features of COVID-19 affected patients. 4, 5 Based on our understanding of the emerging literature, we aim to provide in this short commentary a simple list (►Table 1) of laboratory tests, as may be recommended for patients with COVID-19 and to potentially assist in prognostic monitoring of such patients. keywords: coronavirus; covid-19; disease; patients cache: cord-262626-yk4e737w.txt plain text: cord-262626-yk4e737w.txt item: #851 of 2876 id: cord-262708-hctuxrw9 author: Ramachandra, C. title: Outcomes of Cancer Surgery During the COVID-19 Pandemic: Preparedness to Practising Continuous Cancer Care date: 2020-10-19 words: 2371 flesch: 40 summary: Deprioritisation of nonemergency clinical services and growing concerns of adverse outcomes of COVID-19 in cancer patients is having a deleterious impact across oncologic practice. The pandemic has led to massive redirection of health care resources to treat the surge of COVID-19 patients, hence delivery of health care to the nonCOVID-related diseases including cancer patients has been significantly disrupted. keywords: cancer; covid-19; pandemic; patients; surgeries; years cache: cord-262708-hctuxrw9.txt plain text: cord-262708-hctuxrw9.txt item: #852 of 2876 id: cord-262729-qcijsyo6 author: Eichberg, Daniel G title: Letter: Academic Neurosurgery Department Response to COVID-19 Pandemic: The University of Miami/Jackson Memorial Hospital Model date: 2020-04-11 words: 1091 flesch: 36 summary: With appropriate strategy, it is possible for an academic neurosurgical department to maintain its commitments to neurosurgical patients as well as their community at large and provide safe and effective neurosurgical treatment. Postoperative neurosurgical patients are often medically fragile; thus exposure to COVID-19 may be extremely deleterious. keywords: cases; clinic; patients; visits cache: cord-262729-qcijsyo6.txt plain text: cord-262729-qcijsyo6.txt item: #853 of 2876 id: cord-262766-ndn6iwre author: Easom, Nicholas title: 68 Consecutive patients assessed for COVID-19 infection; experience from a UK regional infectious disease unit date: 2020-03-06 words: 2968 flesch: 38 summary: Specialist Infectious Diseases consultant-delivered assessment of a group of patients who predominantly have mild illness is unlikely to be sustainable, especially as the case-definition broadens to include a wider geographical area and/or COVID-19 patients requiring inpatient care becomes more common in the UK. https://doi.org/10.1101/2020.02.29.20029462 doi: medRxiv preprint A Novel Coronavirus from Patients with Pneumonia in China Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Importation and Human-to-Human transmission of a Novel Coronavirus in Vietnam Evidence of SARS-CoV-2 Infection in Returning Travellers From Wuhan, China Online ahead of print Novel coronavirus disease (Covid-19): the first two patients in the UK with person-to-person transmission keywords: cases; clinical; covid-19; patients; preprint; testing cache: cord-262766-ndn6iwre.txt plain text: cord-262766-ndn6iwre.txt item: #854 of 2876 id: cord-262780-ilu5oskk author: Sattui, Sebastian E. title: Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19 date: 2020-08-11 words: 4658 flesch: 42 summary: Further studies assessing HCQ with or without AZM on QT prolongation in COVID-19 patients emerged [35] . Although the observational design had limitations, it's release was followed by articles in the press highlighting concerns of harm with HCQ use [40] . keywords: coronavirus; covid-19; data; drug; hcq; hydroxychloroquine; patients; public; study; treatment; trial; use cache: cord-262780-ilu5oskk.txt plain text: cord-262780-ilu5oskk.txt item: #855 of 2876 id: cord-262784-r9gq2oan author: Tian, Suochen title: Clinical Characteristics and Reasons for Differences in Duration From Symptom Onset to Release From Quarantine Among Patients With COVID-19 in Liaocheng, China date: 2020-05-12 words: 3755 flesch: 45 summary: Patients in the >20-day group were older, and the time from onset to admission was longer, suggesting that although there was no specific antiviral drug for COVID-19, systematic supportive treatment administered after admission could improve outcomes, even among patients with mild and moderate disease. Front Med (Lausanne) DOI: 10.3389/fmed.2020.00210 sha: doc_id: 262784 cord_uid: r9gq2oan Objective: This study aimed to identify additional characteristics and features of coronavirus disease (COVID-19) by assessing the clinical courses among COVID-19 patients in a region outside Hubei province. keywords: characteristics; clinical; day; disease; group; patients; quarantine cache: cord-262784-r9gq2oan.txt plain text: cord-262784-r9gq2oan.txt item: #856 of 2876 id: cord-262796-syu4wbpi author: Wei, Xiao-Shan title: Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19 date: 2020-04-18 words: 2870 flesch: 52 summary: In this study, we analyzed the differences of the clinical characteristics, laboratory examinations, imaging manifestations and outcomes between COVID-19 patients with diarrhea and those without diarrhea. This study has shown that diarrhea occurred in 31% of SARS-CoV-2 infectious pneumonia patients and is the first report which focus on the difference between COVID-19 patients with diarrhea and those without. keywords: cov-2; covid-19; diarrhea; group; patients; sars; stool cache: cord-262796-syu4wbpi.txt plain text: cord-262796-syu4wbpi.txt item: #857 of 2876 id: cord-262824-xgf5v1ok author: Castillo, Felipe title: On Redeployment to Palliative Care date: 2020-11-10 words: 1136 flesch: 50 summary: Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study The creation of a psychiatry-palliative care liaison team: using psychiatrists to extend palliative care delivery and access during the COVID-19 crisis Interpreting at the end of life: a systematic review of the impact of interpreters on the delivery of palliative care services to cancer patients with limited English proficiency Impact of patient language proficiency and interpreter service use on the quality of psychiatric care: a systematic review Variation in COVID-19 hospitalizations and deaths across New York City boroughs Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Acknowledgments Special thanks to Daniel Shalev, MD, and Ana Berlin, MD, for their contributions to this viewpoint. I bore witness to this conflict play out when I transitioned from the role of researcher working on the national opioid overdose epidemic to the front lines of the pandemic, providing palliative care. keywords: ambivalence; care; hope; patients cache: cord-262824-xgf5v1ok.txt plain text: cord-262824-xgf5v1ok.txt item: #858 of 2876 id: cord-262878-ygvbqmxd author: de Carranza, María title: Aortic thrombus in patients with severe COVID-19: review of three cases date: 2020-07-09 words: 1900 flesch: 36 summary: An increase in the incidence of acute pulmonary thromboembolism (APE) has been recently reported in COVID-19 patients [11] . Different anticoagulant protocols are being used, not only between institutions but also between countries, as no real anticoagulant consensus has been defined for COVID-19 patients keywords: aortic; covid-19; dose; events; patients; thrombus cache: cord-262878-ygvbqmxd.txt plain text: cord-262878-ygvbqmxd.txt item: #859 of 2876 id: cord-262928-l2bqcd0l author: Guarisco, Gloria title: Covid-19 and diabesity: when a pandemia cross another pandemia date: 2020-07-14 words: 2041 flesch: 35 summary: Data from the Intensive Care National Audit & Research Centre (ICNARC) report on COVID-19 in critical care of United Kingdom (March 27th 2020) described that 72.1% of 775 patients with confirmed COVID-19 were overweight or obese and that among patients with Body Mass Index (BMI) > 30 kg/m 2 who had undergone intensive care, 60.9% of them died. Extensive Chinese observational reports on confirmed Covid-19 cases indicated that among patients with the most severe form of disease the prevalence of diabetes was 12-16% keywords: care; covid-19; diabesity; diabetes; obesity; patients cache: cord-262928-l2bqcd0l.txt plain text: cord-262928-l2bqcd0l.txt item: #860 of 2876 id: cord-262954-saqo900k author: Esme, Mert title: Older Adults With Coronavirus Disease 2019; A Nationwide Study in Turkey date: 2020-09-01 words: 4863 flesch: 51 summary: In univariate regression, these geriatric syndromes increase mortality risk in COVID-19 patients. Front Public Health Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis Epidemiology of Covid-19 in a Long-Term Care Facility in King County Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults Changes in hypertension prevalence, awareness, treatment, and control rates in Turkey from Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region COVID-19 spiraling of frailty in older Italian patients Frailty index predicts poor outcome in COVID-19 patients. keywords: age; covid-19; disease; group; mortality; patients; risk; study cache: cord-262954-saqo900k.txt plain text: cord-262954-saqo900k.txt item: #861 of 2876 id: cord-262973-mydn7ver author: Zhang, Dekang title: Experts Consensus on Epidemic Prevention and Control in Radiotherapy Centers during the COVID-19 Outbreak: Experiences from Sichuan Province date: 2020-06-30 words: 2653 flesch: 50 summary: Patients can be accepted only under inpatient status, and the number of patients to be admitted is based on the number of available wards. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding A novel coronavirus outbreak of global health concern Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Estimating the demand for radiotherapy from the evidence: a review of changes from Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Experts consensus of Sichuan Anti-Cancer Association on the prevention and control in radiotherapy places during the COVID-19 epidemic National Health Committee of the People's Republic of China. keywords: area; level; patients; radiotherapy; staff; work cache: cord-262973-mydn7ver.txt plain text: cord-262973-mydn7ver.txt item: #862 of 2876 id: cord-262987-7h91n9ro author: Bin Traiki, Thamer A. title: Impact of COVID-19 pandemic on patient satisfaction and surgical outcomes: A retrospective and cross sectional study date: 2020-08-21 words: 3327 flesch: 43 summary: Therefore, it is important to understand its impact on various parameters of patient care as regards revised infrastructure and policies in hospitals during the pandemic. In light of the above, systematized research is needed to understand the change, if any, in the dynamics of patient care, satisfaction, and post-surgical outcomes with regards to revised infrastructure and policies in hospitals in the wake of infectious pandemics like COVID-19. keywords: care; covid-19; hospital; pandemic; patients; satisfaction; study cache: cord-262987-7h91n9ro.txt plain text: cord-262987-7h91n9ro.txt item: #863 of 2876 id: cord-262998-cugd2t1l author: Singh, Vishwendra title: The novel coronavirus and challenges for general and paediatric dentists date: 2020-05-02 words: 1329 flesch: 45 summary: Dental patients may cough or sneeze during treatment and their salivary (and possibly blood) secretions can become aerosolized during use of ultrasonic instruments or high-speed handpieces. [9] has categorized dental treatments into emergency and non-emergency procedures. keywords: coronavirus; covid-19; dental; patients cache: cord-262998-cugd2t1l.txt plain text: cord-262998-cugd2t1l.txt item: #864 of 2876 id: cord-263031-cco2vh0f author: Vultaggio, Alessandra title: Considerations on Biologicals for Patients with allergic disease in times of the COVID‐19 pandemic: an EAACI Statement date: 2020-06-05 words: 2875 flesch: 31 summary: It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. 36 Benralizumab and omalizumab showed an increase in AEs with low to moderate certainty in severe allergic asthma. keywords: asthma; biologicals; copyright; disease; patients; sars; treatment; type cache: cord-263031-cco2vh0f.txt plain text: cord-263031-cco2vh0f.txt item: #865 of 2876 id: cord-263046-3aerbonz author: Hadfield, James N. title: The Evolving COVID-19 Effect on Hip Fracture Patients date: 2020-06-15 words: 1314 flesch: 46 summary: During the coronavirus pandemic, surgical teams operating on COVID-19 positive patients were subject to stringent personal protective equipment (PPE) protocols in theatre. Early observations and a departmental audit of hip fracture patients admitted during March and April of this year (surgically stabilised) demonstrated a trend to higher 30-day mortality in patients who subsequently tested COVID positive after surgery compared to those who did not. keywords: covid-19; infection; patients cache: cord-263046-3aerbonz.txt plain text: cord-263046-3aerbonz.txt item: #866 of 2876 id: cord-263055-4f25h9l4 author: Fogarty, Helen title: More on COVID‐19 coagulopathy in Caucasian patients date: 2020-05-25 words: 1191 flesch: 29 summary: Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients S Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH Incidence of thrombotic complications in critically ill ICU patients with COVID-19 High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study Thromboinflammation and the hypercoagulability of COVID-19 The weight-adjusted low molecular weight heparin (LMWH) thromboprophylaxis used in the study is that routinely used for hospital in-patients in our institution, consistent with national recommendations [3,4] With respect to the cohort of patients with COVID-19 enrolled in our study, it is important to highlight that 74% of patients received enoxaparin 40mg (4000 IU) subcutaneously once daily. keywords: coagulopathy; covid-19; infection; patients cache: cord-263055-4f25h9l4.txt plain text: cord-263055-4f25h9l4.txt item: #867 of 2876 id: cord-263061-ocplcdiv author: Rivetti, Luigi title: Management of Pacemaker Implantation during COVID-19 Infection date: 2020-10-24 words: 1365 flesch: 33 summary: Furthermore, in our region, the management of COVID-19 patients in dedicated areas has been also assigned to general medical doctors [10] ; thus, it would have been hard for them if the specific management of a tPM is without any previous experience. Case Reports in Cardiology Several guidelines have already proposed different approaches about the management of AV conduction disorders patients; however, no real-world data are available until now in this specific setting. keywords: covid-19; implantation; infection; patient cache: cord-263061-ocplcdiv.txt plain text: cord-263061-ocplcdiv.txt item: #868 of 2876 id: cord-263064-n4c0m5hn author: Choudhury, Ivana title: COVID-19 as a Possible Cause of Functional Exhaustion of CD4 and CD8 T-cells and Persistent Cause of Methicillin-Sensitive Staphylococcus aureus Bacteremia date: 2020-07-04 words: 2248 flesch: 37 summary: In one prospective study of 72 patients, patients with IE associated with MSSA infection significantly had a higher rate of major embolism than MRSA patients, as well as a significantly more unknown origin of bacteremia To our current knowledge, there is sparse clinical evidence suggesting the correlation between COVID-19 infection and its effect on the human immune system, making patients more susceptible to certain infections. keywords: abscess; cells; covid-19; mssa; patient; staphylococcus cache: cord-263064-n4c0m5hn.txt plain text: cord-263064-n4c0m5hn.txt item: #869 of 2876 id: cord-263066-umvojci8 author: Smondack, P. title: Kinésithérapie et COVID-19 : de la réanimation à la réhabilitation à domicile. Synthèse des recommandations internationales date: 2020-10-13 words: 5674 flesch: 55 summary: The hospital anxiety and depression scale Mild cognitive impairment in moderate to severe COPD: a preliminary study Guide de bonnes pratiques en période de COVID relatif à la prise en charge du patient en cabinet de ville Recommandations de la SF2H relatives à l'organisation du parcours des patients, à la protection des patients et des personnels à l'heure du déconfinement et de la reprise de l'activité médico-chirurgicale non COVID-19 en milieu de soins Compendium of physical activities: a second update of codes and MET values Arrêté du 23 mars 2020 prescrivant les mesures d'organisation et de fonctionnement du système de santé nécessaires pour faire face à l'épidémie de covid-19 dans le cadre de l'état d'urgence sanitaire Home-based rehabilitation for COPD using minimal resources: a randomised, controlled equivalence trial Comparison of a structured home-based rehabilitation programme with conventional supervised pulmonary rehabilitation: a randomised non-inferiority trial ATS statement: guidelines for the six-minute walk test An original field evaluation test for chronic obstructive pulmonary disease population: the six-minute stepper test Responsiveness and minimally important difference of the 6-minute stepper test in patients with chronic obstructive pulmonary disease Prise en charge ambulatoire des patients atteints de maladies respiratoires chroniques sévères Functional and postoperative outcomes after preoperative exercise training in patients with lung cancer: a systematic review and meta-analysis De plus, suite au déconfinement de la population et à la réouverture des cabinets libéraux, ces patients peuvent à nouveau être pris en charge en cabinet, dans des conditions d'hygiène adaptées à la pandémie. keywords: charge; covid-19; dans; des; doit; doivent; est; les; masque; par; pas; patients; pour; prise; que; respiratoire; sont; sur; une; être cache: cord-263066-umvojci8.txt plain text: cord-263066-umvojci8.txt item: #870 of 2876 id: cord-263191-osa3ylkl author: Pericàs, Juan M. title: Hospital at home for the management of COVID-19: preliminary experience with 63 patients date: 2020-09-29 words: 1731 flesch: 39 summary: First, the sample size is small and the analysis is based on limited experience of patients collected during a short period of time as previously simultaneously HaH staff was responsible for adapting a Hotel for COVID-19 patients with the same admission criteria as in HaH. Second, the small number of events prevented us to analyze risk factors of readmission, new consultations to the hospital, or death. 95% with F i O2 < 0.35; C Reactive protein < 5 mg/dl or descending, normal LDH or descending, lymphocytes > 800 cells/mm 3 or ascending; no radiological progression of pneumonia; (4) admission from Emergency room: bilateral pneumonia in patient without high-risk factors (> 65 years old, hypertension, chronic obstructive pulmonary disease, cardiovascular disease, diabetes, cancer, and immunosuppression); respiratory infection without pneumonia, or unilobar pneumonia in patients with risk factors. keywords: admission; covid-19; hah; hospital; patients cache: cord-263191-osa3ylkl.txt plain text: cord-263191-osa3ylkl.txt item: #871 of 2876 id: cord-263214-h6lkvlj3 author: Bassi, Massimiliano title: BEDSIDE TRANSCERVICAL-TRANSTRACHEAL POST-INTUBATION INJURY REPAIR IN A COVID-19 PATIENT date: 2020-04-22 words: 1321 flesch: 37 summary: The management of COVID-19 patient can be challenging due to the risk of disease transmission to caregivers and epidemic spread. Management of COVID-19 patients represents a challenge especially during invasive airways interventions (2) . keywords: covid-19; injury; patient; tracheal cache: cord-263214-h6lkvlj3.txt plain text: cord-263214-h6lkvlj3.txt item: #872 of 2876 id: cord-263241-qzerj9bs author: Liu, Liu title: Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction date: 2020-08-20 words: 1543 flesch: 48 summary: People's Medical Publishing House Renal involvement and early prognosis in patients with COVID-19 pneumonia Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation Clinical characteristics of hospitalized patients with 2019 novel coronavirus disease indicate potential proximal tubular dysfunction Hypertension ( Compared with female patients (n = 52), male patients (n = 41) exhibited a significantly lower serum sodium level (136.8 ± 3.7 mmol/L vs. 139.0 ± 2.9 mmol/L; t = 3.191, P = 0.002) and eGFR (86.7 ± 20.6 mL·min À1 ·1.73 m À2 vs. 96.8 ± 19.7 mL·min À1 ·1.73 m À2 , t = 2.384, P = 0.019), and higher serum potassium (4.3 ± 0.5 mmol/L vs. 4.1 ± 0.4 mmol/L, t = À2.044, P = 0.044) and high-sensitivity C-reactive protein ( Only mild proteinuria (+ to ++) was found in all these 27 patients. keywords: patients; proteinuria; renal; study cache: cord-263241-qzerj9bs.txt plain text: cord-263241-qzerj9bs.txt item: #873 of 2876 id: cord-263285-89zqgqx1 author: Sethi, Sanjum S. title: Right Ventricular Clot in Transit in COVID-19: Implications for the Pulmonary Embolism Response Team date: 2020-05-29 words: 1856 flesch: 36 summary: After presenting a case of right ventricular thrombus in a COVID-19 patient, we discuss the unique challenges in the workup and treatment of COVID-19 patients highlighting our COVID-19 modified pulmonary embolism response team (PERT) algorithm. Given this increased potential for hypercoagulable events, yet being mindful of exposure risks and practical considerations in caring for COVID-19 patients, we present the first report of a COVID-19 patient with clot in transit, along with an algorithm for diagnosing and treating venous thromboembolism in COVID-19 patients. keywords: acute; anticoagulation; covid-19; embolism; illness; patient cache: cord-263285-89zqgqx1.txt plain text: cord-263285-89zqgqx1.txt item: #874 of 2876 id: cord-263292-qjfe2t9v author: Sansone, A. title: Addressing male sexual and reproductive health in the wake of COVID-19 outbreak date: 2020-07-13 words: 3913 flesch: 27 summary: The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis Effect of SARS-CoV-2 infection upon male gonadal function: a single center-based study COVID-19 and the endocrine system: exploring the unexplored Pathological findings in the testes of COVID-19 patients: clinical implications Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients A critical analysis of the role of testosterone in erectile function: from pathophysiology to treatment-a systematic review The relationship between circulating testosterone and inflammatory cytokines in men Androgen sensitivity gateway to COVID-19 disease severity The interface of systems medicine and sexual medicine for facing non-communicable diseases in a gender-dependent manner ED2: erectile dysfunction = endothelial dysfunction SARS-CoV-2: a storm is raging From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome Testosterone replacement therapy: the emperor's new clothes Effect of treatment with testosterone on endothelial function in hypogonadal men: a systematic review and meta-analysis Erectile dysfunction as a predictor of cardiovascular disease Why can patients with erectile dysfunction be considered lucky? Testicular function in COVID-19 patients requires careful investigation for the unclear association with testosterone deficiency and the possible consequences for reproductive health. keywords: cov-2; covid-19; disease; dysfunction; erectile; health; infection; pandemic; patients; sars; testosterone cache: cord-263292-qjfe2t9v.txt plain text: cord-263292-qjfe2t9v.txt item: #875 of 2876 id: cord-263294-9r84f19u author: Chen, Siyu title: Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia date: 2020-04-10 words: 1071 flesch: 40 summary: All five cases of pregnant women confirmed COVID‐19 were collected among patients who admitted to the Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020. key: cord-263294-9r84f19u authors: Chen, Siyu; Liao, E.; Cao, Dongmei; Gao, Ying; Sun, Guoqiang; Shao, Yong title: Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia date: 2020-04-10 journal: J Med Virol DOI: 10.1002/jmv.25789 sha: doc_id: 263294 cord_uid: 9r84f19u keywords: delivery; fever; patients; women cache: cord-263294-9r84f19u.txt plain text: cord-263294-9r84f19u.txt item: #876 of 2876 id: cord-263530-t9ryky6f author: Kamal, Yasmine Mohamed title: Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully date: 2020-09-16 words: 2492 flesch: 41 summary: ► A red flag of the possibility of COVID-19 encephalitis should be raised whenever patients present with abnormal behaviour, acute psychosis, confusion state or drowsiness. Analysis of clinical outcomes in pediatric bacterial meningitis focusing on patients without cerebrospinal fluid pleocytosis Normocellular CSF in herpes simplex encephalitis COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report We would like to thank Dr Raheel Ahmed for his assistance in direct patient care, as well as Dr Maria Khan, for the final review of the article. keywords: brain; covid-19; csf; encephalitis; patient; symptoms cache: cord-263530-t9ryky6f.txt plain text: cord-263530-t9ryky6f.txt item: #877 of 2876 id: cord-263599-cqol8zf2 author: Goodman, Larry title: Infectious diarrhea date: 1999-07-31 words: 11536 flesch: 47 summary: Table 4 summarizes the characteristics of the various E coli diarrhea pathogens. Other bacteria, parasites, and viruses account for a significant percentage of diarrhea cases and frequently go undetected. keywords: campylobacter; cases; cause; coli; diarrhea; disease; fever; food; infection; organisms; pathogens; patients; risk; salmonella; states; stool; syndrome; toxin; treatment; water cache: cord-263599-cqol8zf2.txt plain text: cord-263599-cqol8zf2.txt item: #878 of 2876 id: cord-263628-ac9gld5l author: Sivapalan, Pradeesh title: Proactive prophylaxis with azithromycin and hydroxychloroquine in hospitalized patients with COVID-19 (ProPAC-COVID): a statistical analysis plan date: 2020-10-20 words: 3492 flesch: 46 summary: Data is analyzed using intention-to-treat (ITT) principles, and main analyses will also be subject to modified ITT analysis and per protocol analysis. Data will be analyzed using intention-to-treat (ITT) principles and main analyses will also be subject to modified ITT analysis (started but not completed the study) and per protocol analysis (completed all interventions). keywords: analysis; data; days; oxygen; patients; study; test; treatment; trial cache: cord-263628-ac9gld5l.txt plain text: cord-263628-ac9gld5l.txt item: #879 of 2876 id: cord-263691-ovsi38bx author: Sadler, Diego title: Practical and cost-effective model to build and sustain a cardio-oncology program date: 2020-07-16 words: 5466 flesch: 33 summary: The Heart and Vascular Institute support was displayed by allowing the cardiologist to spend an increasing amount of the time in the CO clinic, blocking dedicated time for CO, allowing longer appointment times for CO patients, and assigning cardiology nurses to the cancer center for the CO clinic. However, despite its momentum, CO programs exist predominately in large, academic, quaternary institutions [7] . keywords: cancer; cardio; cardiovascular; center; clinic; oncology; patients; program; treatment cache: cord-263691-ovsi38bx.txt plain text: cord-263691-ovsi38bx.txt item: #880 of 2876 id: cord-263716-ywsm11aw author: Zhou, Yifan title: Clinical time course of COVID-19, its neurological manifestation and some thoughts on its management date: 2020-05-04 words: 1798 flesch: 56 summary: In severe patients, 5 (6%) had strokes, 13 (15%) had cognitive impairment and 17 (19%) had musculoskeletal damage. 14 15 In severe patients, retaining CO 2 is a challenging problem. keywords: covid-19; infection; patients; phase; symptoms cache: cord-263716-ywsm11aw.txt plain text: cord-263716-ywsm11aw.txt item: #881 of 2876 id: cord-263793-bmadusm6 author: Velissaris, Dimitrios title: Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group date: 2020-05-12 words: 3764 flesch: 45 summary: Patients were stratified into four strata of severity considering suPAR and the APACHE (Acute Physiology and Chronic Health Evaluation) II score; suPAR \ 12 ng/ml and APACHE II \ 17; suPAR C 12 ng/ ml and APACHE II \ 17; suPAR \ 12 ng/ml and APACHE II C 17; suPAR C 12 ng/ml and APACHE II C 17. This generates the question of whether suPAR may help trace the patients among those with one sign of qSOFA at significantly greater risk of death compared with those with one sign of qSOFA but without increased suPAR. keywords: levels; patients; risk; sepsis; study; supar cache: cord-263793-bmadusm6.txt plain text: cord-263793-bmadusm6.txt item: #882 of 2876 id: cord-263882-s5oxr6es author: Najar Nobar, Niloufar title: Patients with specific skin disorders who are affected by COVID‐19: what do experiences say about management strategies? : A systematic review date: 2020-06-18 words: 2546 flesch: 33 summary: Cutaneous manifestations in COVID-19: a first perspective Cutaneous manifestations in COVID-19: a first perspective by Recalcati S Clinical and Histopathological study of skin dermatoses in patients affected by COVID-19 infection in the Northern part of Italy Cutaneous manifestations of COVID-19: Report of three cases and a review of literature Dermatologic findings in two patients with COVID-19 Cutaneous manifestation of COVID-19 in images: A case report Alert for non-respiratory symptoms of Coronavirus Disease 2019 (COVID-19) patients in epidemic period: A case report of familial cluster with three asymptomatic COVID-19 patients Occupational skin disease among health care workers during the coronavirus (COVID-19) epidemic A distinctive skin rash associated with Coronavirus Disease A Case of COVID-19 Pneumonia in a Young Male with Full Body Rash as a Presenting Symptom Morbilliform exanthem associated with COVID-19 Rash as a Clinical Manifestation of COVID 19 Photographs of a Patient SARS-CoV-2 infection presenting as a febrile rash Urticarial eruption in COVID-19 infection Urticarial exanthem as early diagnostic clue for COVID-19 infection A case of COVID-19 presenting in clinical picture resembling chilblains disease. No evidence of increased risk for COVID-19 infection in patients treated with Dupilumab for atopic dermatitis in a high-epidemic area Systemic Isotretinoin Therapy In The Era Of COVID19 Evolution of COVID-19 infection in 4 psoriatic patients treated with biological drugs Occurrence of SARS-CoV-2 during mycophenolate mofetil treatment for pemphigus Mucous membrane pemphigoid and COVID-19 treated with highdose intravenous immunoglobulins: a case-report COVID-19 pulmonary infection in erythrodermic psoriatic patient with oligodendroglioma: safety and compatibility of apremilast with critical intensive care management A challenging case of psoriasis flare-up after COVID-19 infection COVID-19 in an elderly patient treated with secukinumab Improvement of SARS-CoV2 symptoms following Guselkumab injection in a psoriatic patient SARS-CoV-2 infection in a psoriatic patient treated with IL-23 inhibitor Systemic Immunobiological, Immunosuppressant and Oncologic Agents for the Treatment of Dermatologic Diseases during the SARS-Cov-2 (COVID19) Pandemic Emergency: a Quick Review for a Quick Consultation Evaluating the role of stress in skin disease. keywords: covid-19; disease; infection; patients; skin; treatment cache: cord-263882-s5oxr6es.txt plain text: cord-263882-s5oxr6es.txt item: #883 of 2876 id: cord-263883-7ba0huwy author: Ansarin, Khalil title: Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial date: 2020-07-19 words: 3121 flesch: 47 summary: The data analysis of this clinical trial also showed that cardinal respiratory symptoms (cough, lassitude, and dyspnea) in patients with COVID-19 disease who received bromhexine treatment was remarkably less than the standard group. Patients with COVID-19 disease release high amounts of LDH into circulation due to cytokine release and lung damage. keywords: arm; bromhexine; covid-19; disease; group; patients; standard; treatment cache: cord-263883-7ba0huwy.txt plain text: cord-263883-7ba0huwy.txt item: #884 of 2876 id: cord-263908-4ti8l2ea author: Gupta, Ritesh title: Diabetes and COVID-19: evidence, current status and unanswered research questions date: 2020-05-13 words: 3695 flesch: 41 summary: Prevalence ofcomorbidities in the novel Wuhan coronavirus (COVID-19) infection: asystematicreview and meta-analysis Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Effects of hypertension, diabetes and coronary heart disease on COVID-19 diseases severity: a systematic review and meta-analysis Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention Glycemic characteristics and clinical outcomes of COVID-19 patients hospitalized in the United States Glycemic control and risk of infections among people with type 1 or type 2 diabetes in a large primary care cohort study Type 2 diabetes mellitus and altered immune system leading to Diabetes and COVID-19: evidence, current status and unanswered research questions susceptibility to pathogens, especially mycobacterium tuberculosis T-cell activation and cardiovascular risk in adults with type 2 diabetes mellitus: A systematic review and meta-analysis Covid-19 and diabetes mellitus: unveiling the interaction of two pandemics Obesity and the risk and outcome of infection Elevated Plasmin(ogen) as a common risk factor for COVID-19 susceptibility Diabetes is a risk factor for the progression and prognosis of COVID-19 Plasma levels of the proprotein convertase furinandincidence of diabetes and mortality There have been a lot of literature and debate whether these drugs could benefit or harm patients having COVID-19 infection. keywords: ace2; angiotensin; covid-19; diabetes; disease; infection; inhibitors; patients; risk cache: cord-263908-4ti8l2ea.txt plain text: cord-263908-4ti8l2ea.txt item: #885 of 2876 id: cord-264042-4hc2i25r author: Chim, Harvey title: Severe Acute Respiratory Syndrome in a Naval Diver date: 2006-06-17 words: 2135 flesch: 46 summary: Therefore, our goals were twofold: (1) to detect SARS cases early and to break any chain of transmission and (2) to prevent the onset of infection. Mil Med DOI: 10.7205/milmed.171.6.491 sha: doc_id: 264042 cord_uid: 4hc2i25r Severe acute respiratory syndrome (SARS) is a highly infectious, rapidly progressive, emerging disease. keywords: diving; measures; patient; personnel; sars cache: cord-264042-4hc2i25r.txt plain text: cord-264042-4hc2i25r.txt item: #886 of 2876 id: cord-264073-yhztrscf author: Betonico, Gustavo Navarro title: Challenges in COVID‐19 medical response: a nephrology perspective date: 2020-06-20 words: 1706 flesch: 41 summary: In general, dialysis indications in COVID-19 patients follow the same recommendations as in other acute kidney injuries. All this volume-restricted protocols in COVID-19 patients must keep ICU staff This article is protected by copyright. keywords: covid-19; dialysis; disease; kidney; patients; symptoms cache: cord-264073-yhztrscf.txt plain text: cord-264073-yhztrscf.txt item: #887 of 2876 id: cord-264122-n64tm6qr author: Gaballa, Salem title: COVID-19 Fears May Be Worse Than the Virus: A Case of Cardiogenic Shock Secondary to Post-Myocardial Infarction Ventricular Septum Rupture date: 2020-06-24 words: 2329 flesch: 43 summary: Ventricular septal rupture following acute myocardial infarction Operative management of postinfarction ventricular septal defect Surgical management of postinfarction ventricular septal rupture Post-infarction ventricular septal defect: risk factors and early outcomes Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction Outcome and profile of ventricular septal rupture with cardiogenic shock after myocardial infarction: a report from the SHOCK Trial Registry Ventricular septal rupture after acute myocardial infarction JP: Cardiac tamponade. A study of 50 hearts The in vivo morphology of post-infarct ventricular septal defect and the implications for closure Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence Identification and treatment of complications of myocardial infarction Post infarction ventricular septal defect -can we do better ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the Society of Thoracic Surgeons National Database Amplatzer septal occluder to treat iatrogenic cardiac perforations Current surgical approach to acute ventricular septal rupture Percutaneous closure of postinfarction ventricular septal defect: in-hospital outcomes and long-term follow-up of UK experience Immediate primary transcatheter closure of postinfarction ventricular septal defects keywords: infarction; patients; rupture; septal; ventricular; vsr cache: cord-264122-n64tm6qr.txt plain text: cord-264122-n64tm6qr.txt item: #888 of 2876 id: cord-264180-0vd3tr9j author: Gupta, Anupam K title: Is It Safe to Perform Lung Surgery During the Coronavirus Pandemic? date: 2020-08-14 words: 1636 flesch: 58 summary: This study was conducted to evaluate whether it is safe to perform lung surgery in the community where there is a rapidly increasing number of coronavirus patients. Conclusion: With adequate precautions, older patients can undergo lung surgery during this pandemic. keywords: coronavirus; covid-19; patients; surgery cache: cord-264180-0vd3tr9j.txt plain text: cord-264180-0vd3tr9j.txt item: #889 of 2876 id: cord-264295-7ojvhwb0 author: Maddaloni, Ernesto title: Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors: a multicentre retrospective study (CoViDiab II) date: 2020-10-01 words: 4691 flesch: 34 summary: Age and sex adjusted regression models confirmed that Covid-19 patients with the primary composite outcome were more likely to have diabetes (adjusted odds ratio [ adj OR] 2.04, 95% confidence interval Overall our results confirm previous findings from other countries that Covid-19 patients with diabetes are more likely to require intensive care or to die, compared with Covid-19 patients without diabetes [12, 19, 20, 27] , and in addition suggest this association is driven by the presence of cardiometabolic multimorbidity rather than by diabetes alone. keywords: cardiometabolic; composite; covid-19; data; diabetes; outcome; patients; risk; study cache: cord-264295-7ojvhwb0.txt plain text: cord-264295-7ojvhwb0.txt item: #890 of 2876 id: cord-264327-uzlavmhx author: Singh, Rajat title: Novel Coronavirus Disease 2019 in a Patient on Durable Left Ventricular Assist Device Support date: 2020-04-17 words: 884 flesch: 36 summary: The Role of Prone Ventilation Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Activation-induced T-cell death and immune dysfunction after implantation of left-ventricular assist device Cellular immunity impaired among patients on left ventricular assist device for 6 months Recent evidence suggests that patients with cardiovascular comorbidities appear to be at increased risk of morbidity and mortality with COVID-19. keywords: covid-19; failure; lvad; patient cache: cord-264327-uzlavmhx.txt plain text: cord-264327-uzlavmhx.txt item: #891 of 2876 id: cord-264368-p2fwuh0i author: Gozgec, Elif title: Left Ventricular Thrombus in a Patient Infecting by Covid-19 date: 2020-07-28 words: 248 flesch: 47 summary: Ann Thorac Surg DOI: 10.1016/j.athoracsur.2020.07.008 sha: doc_id: 264368 cord_uid: p2fwuh0i nan A 74-year-old woman presented with general condition disorder, nausea and vomiting. The patient had general condition disorder but had no known systemic disease, history of trauma, or medication. keywords: thrombus cache: cord-264368-p2fwuh0i.txt plain text: cord-264368-p2fwuh0i.txt item: #892 of 2876 id: cord-264449-p3tgjuj4 author: Majumdar, PK title: Orthopaedic Surgery in Times of COVID-19 in India date: 2020-07-17 words: 1735 flesch: 41 summary: Hence, this case restriction is not applicable for private hospitals and elective patients are still receiving care. We should continue to study best practices, such as the routine swabbing of pre-surgical patients 4 , anticoagulation in view of possible thrombotic tendencies 5 , and remain open to adopting them in practice. keywords: covid-19; hospital; orthopaedic; patients; surgeons; surgeries cache: cord-264449-p3tgjuj4.txt plain text: cord-264449-p3tgjuj4.txt item: #893 of 2876 id: cord-264504-nnvof29x author: Malentacchi, Maria title: Concomitant brain arterial and venous thrombosis in a COVID‐19 patient date: 2020-06-05 words: 823 flesch: 31 summary: This last hypothesis has been already described in COVID-19 patients. In addition, other comorbidities (leukemia) and the recent use of steroids could influence the prothrombotic status of our patient. Acute and subacute consciousness deterioration in COVID-19 patients could be due to different pathogenetic mechanisms: nevertheless, the probability of acute cerebrovascular disease represents the main cause as encephalitis, for example, has been described in few case reports. keywords: cases; covid-19; patient cache: cord-264504-nnvof29x.txt plain text: cord-264504-nnvof29x.txt item: #894 of 2876 id: cord-264543-b4zwinh2 author: Daher, Valéria Barcelos title: Anosmia: A marker of infection by the new corona virus date: 2020-06-12 words: 1722 flesch: 43 summary: Patient MFDJ, 31-year-old, brown, single, previously healthy, from Goiânia, Brazil, works as an orthopedics resident physician at São Paulo School Hospital, Brazil, attending patients of the specialty in different sectors, including the Intensive Care Unit, where several patients were under treatment because of infection laboratorialy confirmed of the new corona virus (SARS-CoV-2). In the case described, the patient presented as initial symptoms anosmia (absence of smell) and ageusia (change in taste) followed by odynophagia, cough, low fever, chest pain and mild respiratory distress, so it was considered suggestive of Covid-19 and confirmed, later, by the laboratory examination (RT-PCR) of the patient. keywords: anosmia; case; covid-19; patient; symptoms; virus cache: cord-264543-b4zwinh2.txt plain text: cord-264543-b4zwinh2.txt item: #895 of 2876 id: cord-264610-kxebc12r author: Chen, Yu title: Clinical characteristics of IgG4-RD patients infected with COVID-19 in Hubei, China date: 2020-05-16 words: 1749 flesch: 39 summary: The symptoms such as fever and cough and radiologic features were similar to other COVID-19 patients. In our study, patient 2 took a long time for SARS-Cov-2 nucleic acid to turn negative, which may implicated that the viral load in such patients may need to be monitored for a longer time after discharge. keywords: covid-19; disease; igg4; patients cache: cord-264610-kxebc12r.txt plain text: cord-264610-kxebc12r.txt item: #896 of 2876 id: cord-264647-9r443j3l author: Talamonti, G. title: Spinal epidural abscess in COVID-19 patients date: 2020-09-10 words: 2925 flesch: 47 summary: key: cord-264647-9r443j3l authors: Talamonti, G.; Colistra, Davide; Crisà, Francesco; Cenzato, Marco; Giorgi, Pietro; D’Aliberti, Giuseppe title: Spinal epidural abscess in COVID-19 patients date: 2020-09-10 journal: J Neurol DOI: 10.1007/s00415-020-10211-z sha: doc_id: 264647 cord_uid: 9r443j3l OBJECTIVE: To report the peculiarity of spinal epidural abscess in COVID-19 patients, as we have observed an unusually high number of these patients following the outbreak of SARS-Corona Virus-2. To our knowledge, cases of spinal epidural abscess in COVID-19 patients have not been reported to date. keywords: abscess; cases; covid-19; patients; sea; spinal cache: cord-264647-9r443j3l.txt plain text: cord-264647-9r443j3l.txt item: #897 of 2876 id: cord-264673-67zopf7s author: Shi, Hongbo title: The inhibition of IL-2/IL-2R gives rise to CD8(+) T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia date: 2020-06-08 words: 3369 flesch: 49 summary: Notably, the absolute lymphocyte count in critical patients was significantly lower than that in common or severe patients, but there was no difference between common patients and severe patients (Fig. 1a ). The level of interleukin-2 (IL-2) in critical patients was significantly lower than that in severe patients, whereas the level of IL-2 in severe patients was higher than that in normal controls and common patients (Fig. 3a) . keywords: cd8; cells; controls; covid-19; fig; patients; pneumonia cache: cord-264673-67zopf7s.txt plain text: cord-264673-67zopf7s.txt item: #898 of 2876 id: cord-264751-2l3cqhe2 author: Gawie-Rotman, Moran title: Purpuric rash and fever among hospitalized children aged 0–18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology date: 2019-02-22 words: 3259 flesch: 39 summary: patients with PRF caused by a proven Rickettsial infection and 4 (5.8%) additional patients with a clinical picture appropriate for Rickettsial infection. key: cord-264751-2l3cqhe2 authors: Gawie-Rotman, Moran; Hazan, Guy; Fruchtman, Yariv; Cavari, Yuval; Ling, Eduard; Lazar, Isaac; Leibovitz, Eugene title: Purpuric rash and fever among hospitalized children aged 0–18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology date: 2019-02-22 journal: Pediatr Neonatol DOI: 10.1016/j.pedneo.2019.02.002 sha: doc_id: 264751 cord_uid: 2l3cqhe2 BACKGROUND: keywords: children; disease; etiology; patients; prf; study cache: cord-264751-2l3cqhe2.txt plain text: cord-264751-2l3cqhe2.txt item: #899 of 2876 id: cord-264779-71s7e18i author: Neumann, Natalie R. title: Medical Toxicology and COVID-19: Our Role in a Pandemic date: 2020-04-30 words: 1930 flesch: 35 summary: Lastly, poison centers, historically considered an underutilized source for reporting adverse drug reactions, may be more mindful of tracking and reporting toxicity from novel therapies [26] . The Lancet Respiratory Medicine FDA advises patients on use of nonsteroidal anti-inflammatory drugs (NSAIDs) for COVID-19 A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirusinduced lung injury Liver injury in COVID-19: management and challenges Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Pathological findings of COVID-19 associated with acute respiratory distress syndrome Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study COVID-19 and the liver: little cause for concern Insufficient stocking of poisoning antidotes in hospital pharmacies Availability of antidotes at acute care hospitals in Ontario National audit of antidote stocking in acute hospitals in the UK Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care Royal College of Emergency Medicine and National Poisons Information Service Reporting of adverse drug reactions by poison control centres in the US MedWatch: keywords: covid-19; drug; hospital; information; medical; patients; toxicology cache: cord-264779-71s7e18i.txt plain text: cord-264779-71s7e18i.txt item: #900 of 2876 id: cord-264829-ynel6ore author: Momtazmanesh, Sara title: Cardiovascular disease in COVID-19: a systematic review and meta-analysis of 10,898 patients and proposal of a triage risk stratification tool date: 2020-07-13 words: 7975 flesch: 43 summary: Interact Cardiovasc Thorac Surg Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range Hospitalization and critical care of 109 decedents with COVID-19 pneumonia in Wuhan, China Clinical features and treatment of COVID-19 patients in northeast Chongqing Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: a retrospective observational study Prognostic value of NT-proBNP in patients with severe COVID-19 Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-COVID-NET, 14 States Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) China Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan Clinical analysis of 150 cases of 2019 novel coronavirus infection in Nanyang City Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2 Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized With COVID-19 Clinical characteristics of 161 cases of corona virus disease 2019 (COVID-19) in Changsha Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Heart failure and liver disease: cardiohepatic interactions Cardiohepatic interactions in heart failure: an overview and clinical implications Right Heart Failure and Cardiorenal Syndrome An Update on the pathophysiology and treatment of cardiorenal syndrome Cardiorenal syndrome: multi-organ dysfunction involving the heart, kidney and vasculature Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin First case of COVID-19 complicated with fulminant myocarditis: a case report and insights Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to Ddimer levels COVID-19 pneumonia with hemoptysis: acute segmental pulmonary emboli associated with novel coronavirus infection Severe Acute Proximal Pulmonary Embolism and COVID-19: keywords: acute; analysis; clinical; coronavirus; covid-19; disease; frequency; icu; injury; levels; patients; studies cache: cord-264829-ynel6ore.txt plain text: cord-264829-ynel6ore.txt item: #901 of 2876 id: cord-264843-cwtdkylo author: Chen, Justin A. title: COVID-19 and telepsychiatry: Early outpatient experiences and implications for the future date: 2020-07-09 words: 4034 flesch: 36 summary: In this paper, the term telepsychiatry is used to refer to real-time video and/or audio connection between mental health clinicians and patients, including mental health services delivered by telephone. Early analyses suggest that these changes have enabled mental health clinicians to continue to provide vital care at a challenging time. keywords: care; clinicians; covid-19; patients; person; telehealth; telepsychiatry; treatment cache: cord-264843-cwtdkylo.txt plain text: cord-264843-cwtdkylo.txt item: #902 of 2876 id: cord-264889-1vsvcza2 author: Jackson, Craig T. title: The Ties That Bind: A Coronavirus Disease Journey date: 2020-10-16 words: 1129 flesch: 51 summary: As friends on a COVID journey, we shared our appreciation of ICU care as a team sport. Some describe COVID critical care management as creating a delirium factory. keywords: care; experience; icu; patient cache: cord-264889-1vsvcza2.txt plain text: cord-264889-1vsvcza2.txt item: #903 of 2876 id: cord-264924-ds6jv5ek author: Tambyah, Paul A title: Severe acute respiratory syndrome from the trenches, at a Singapore university hospital date: 2004-11-30 words: 5460 flesch: 46 summary: The previous day, the Ministry of Health in Singapore had declared Tan Tock Seng Hospital (TTSH), where the first cluster of SARS infections happened, as the national SARS hospital. The September 2003 laboratory acquired SARS case 30 was a setback to our SARS containment plans. keywords: epidemic; hospital; infection; patients; sars; singapore; syndrome; transmission; virus cache: cord-264924-ds6jv5ek.txt plain text: cord-264924-ds6jv5ek.txt item: #904 of 2876 id: cord-264952-0t0t4x0y author: Smith, Sean R title: Proposed Workflow for Rehabilitation in a Field Hospital Setting During the COVID‐19 Pandemic date: 2020-05-15 words: 2973 flesch: 45 summary: Of course, patients with impaired cognition may have delirium without a brain injury and still benefit from field hospital rehabilitation. This assessment tool was created based on clinical characteristics of COVID-19 patients and from components of an assessment published by the International Rehab Forum [7] and the Barthel Index. keywords: care; covid-19; field; hospital; patients; rehabilitation cache: cord-264952-0t0t4x0y.txt plain text: cord-264952-0t0t4x0y.txt item: #905 of 2876 id: cord-264972-hrbo3awj author: Yee, Colin title: Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting date: 2016-11-01 words: 1703 flesch: 31 summary: Most influenza-positive patients, who were not treated empirically, were highly likely to be initiated after the test results: 80% (8/10) among hospitalized patients and 85% (6/7) among emergency room patients scheduled to be admitted. key: cord-264972-hrbo3awj authors: Yee, Colin; Suarthana, Eva; Dendukuri, Nandini; Nicolau, Ioana; Semret, Makeda; Frenette, Charles title: Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting date: 2016-11-01 journal: Am J Infect Control DOI: 10.1016/j.ajic.2016.04.221 sha: doc_id: keywords: influenza; mrvp; patients; test cache: cord-264972-hrbo3awj.txt plain text: cord-264972-hrbo3awj.txt item: #906 of 2876 id: cord-265022-p5cab562 author: Kotfis, Katarzyna title: COVID-19: ICU delirium management during SARS-CoV-2 pandemic date: 2020-04-28 words: 5433 flesch: 28 summary: The Intensive Care Delirium Screening Checklist (ICDSC)--translation and validation of intensive care delirium checklist in accordance with guidelines A novel coronavirus from patients with pneumonia in China Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan Fair Allocation of Scarce Medical Resources in the Time of Covid-19 Sedative and analgesic medications are independent risk factors in ICU patients for transitioning into delirium Use of medications with anticholinergic effect predicts clinical severity of delirium symptoms in older medical inpatients Caring for critically ill patients with the ABCDEF bundle: results of the ICU liberation collaborative in over 15,000 adults The ABCDEF bundle: science and philosophy of how ICU liberation serves patients and families Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF bundle in 6,064 patients Clinical and team management in the COVID-ICU: successful strategies from the first week Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Multiple organ infection and the pathogenesis of SARS Neurotropic virus tracing suggests a membranous-coatingmediated mechanism for transsynaptic communication SARS: clinical features and diagnosis The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Neuroinvasion by human respiratory coronaviruses Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human Dipeptidyl peptidase 4 Novel coronavirus is putting the whole world on alert Neurotropism of human coronavirus 229E Characteristics of a coronavirus (strain 67N) of pigs Detection of coronavirus in the central nervous system of a child with acute disseminated encephalomyelitis Neurologic complications of coronavirus infections Coronavirus infections in the central nervous system and respiratory tract show distinct features in hospitalized children COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features. However, the standard of care for ICU patients, including delirium management, must remain the highest quality possible with an eye towards long-term survival and minimization of issues related to post-intensive care syndrome (PICS). keywords: acute; brain; care; coronavirus; cov-2; covid-19; delirium; icu; management; patients; risk; sars; unit cache: cord-265022-p5cab562.txt plain text: cord-265022-p5cab562.txt item: #907 of 2876 id: cord-265052-hfuvm1oh author: Turan, Çağrı title: Change of the diagnostic distribution in applicants to dermatology after COVID ‐19 pandemic: What it whispers to us? date: 2020-06-12 words: 4119 flesch: 50 summary: It was determined that 9531 (9.2%) of 104142 applications to all clinical departments, except COVID-19 outpatient clinic, were made to dermatology outpatient clinics within 12 weeks (12 February-8 May 2020). All rights reserved. one or more of the following reasons: The risk perception of patients in this group is similar, the treatment plan for chronic diseases is pre-drawn, and some diseases do not cause severe deterioration in their QoL. The frequency decline in diseases such as verruca vulgaris, hyperpigmentation, skin tag, melanocytic nevus, seborrheic keratosis/solar lentigo suggested that these diseases do not affect the QoL too much or that such diseases can be ignored during the outbreak. keywords: applications; covid-19; dermatology; diseases; frequency; outpatient; patients; weeks cache: cord-265052-hfuvm1oh.txt plain text: cord-265052-hfuvm1oh.txt item: #908 of 2876 id: cord-265053-x70501t3 author: Pourhomayoun, Mohammad title: Predicting Mortality Risk in Patients with COVID-19 Using Artificial Intelligence to Help Medical Decision-Making date: 2020-04-01 words: 1860 flesch: 44 summary: A model of beds needed and available for Coronavirus patients Interactive Dimensionality Reduction for Improving Patient Adherence in Remote Health Monitoring Risk Prediction of Critical Vital Signs for ICU Patients Using Recurrent Neural Network Multiple model analytics for adverse event prediction in remote health monitoring systems Interactive Predictive Analytics for Enhancing Patient Adherence in Remote Health Monitoring Multi-label Classification of Single and Clustered Cervical Cells Using Deep Convolutional Networks Context-Aware Data Analytics for Activity Recognition Machine Learning The Nature of Statistical Learning Theory Random Forests This system can help hospitals, medical facilities, and caregivers decide who needs to get attention first before other patients, triage patients when the system is overwhelmed by overcrowding, and also eliminate delays in providing the necessary care. Finally, we used a separate dataset of COVID-19 patients to evaluate our developed model accuracy, and used confusion matrix to make an in-depth analysis of our classifiers and calculate the sensitivity and specificity of our model. keywords: covid-19; data; features; model; patients cache: cord-265053-x70501t3.txt plain text: cord-265053-x70501t3.txt item: #909 of 2876 id: cord-265082-gjbabh4g author: Xuan, Tian-ming title: Primary percutaneous coronary intervention in a COVID-19 patient with ST-segment elevation myocardial infarction after lung transplantation: a case report date: 2020-05-09 words: 1991 flesch: 39 summary: (e) ECG shows diffuse ST-segment elevation through V1 to V6 leads arteries, which affects coronary blood flow and leads to myocardial infarction, and Type 2 refers to an imbalance of myocardial blood supply/demand caused by specific factors that can lead to myocardial ischemic infarction. Recent studies have shown that COVID-19 patients also have cytokine storms caused by the imbalance of T helper type 1 (Th1) and Th2 responses, and the levels of inflammatory factors IL-4, IL-10, and IL-6 in tissue samples were increased (Chen et al., 2020; Huang et al., 2020) . keywords: coronary; covid-19; day; infarction; lung; patient; transplantation cache: cord-265082-gjbabh4g.txt plain text: cord-265082-gjbabh4g.txt item: #910 of 2876 id: cord-265098-u5qssib9 author: Fu, Xin-yan title: Effect of COVID-19 outbreak on the treatment time of patients with acute ST-segment elevation myocardial infarction date: 2020-09-17 words: 1361 flesch: 47 summary: We retrospectively reviewed the data of STEMI patients admitted to the Hangzhou Chest Pain Center (CPC) during a COVID-19 epidemic period in 2020 (24 cases) and the same period in 2019 (29 cases). The pre-hospital and in-hospital treatment times of STEMI patients during the COVID-19 epidemic were longer than those before the epidemic. keywords: epidemic; infarction; patients; stemi; treatment cache: cord-265098-u5qssib9.txt plain text: cord-265098-u5qssib9.txt item: #911 of 2876 id: cord-265111-d44ireu5 author: D’Ardes, Damiano title: Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids date: 2020-08-31 words: 3105 flesch: 36 summary: Notwithstanding the many limitations of these study, such as the small sample size, these observations could add new information to the settings of prevention and treatment of COVID-19 patients, contributing to the worldwide battle against the SARS-CoV-2 pandemic. We considered a cohort of patients recovered from COVID-19 showing that the median disease duration between onset and end of COVID-19 symptoms was 27.5 days (interquartile range (IQR): 17.0–33.2) and that the median duration between onset of symptoms and microbiological healing, defined by two consecutive negative nasopharyngeal swabs, was 38 days (IQR: 31.7–50.2). keywords: cov-2; covid-19; disease; duration; patients; sars; shedding cache: cord-265111-d44ireu5.txt plain text: cord-265111-d44ireu5.txt item: #912 of 2876 id: cord-265230-ozyx8u64 author: Takahari, Daisuke title: Managing a gastrointestinal oncology practice in Japan during the COVID-19 pandemic: single institutional experience in The Cancer Institute Hospital of Japanese Foundation for Cancer Research date: 2020-10-21 words: 5756 flesch: 38 summary: Various reports have shown data indicating that cancer patients with COVID-19 have high morbidity and mortality rates. For cancer patients, of course, hospital visits for treatment and assessments are not subject to restriction, but the visits themselves can be a risk of infection, especially for individuals who have risk factors of COVID-19 infection. keywords: cancer; chemotherapy; clinical; covid-19; infection; japan; pandemic; patients; risk; s-1; treatment; trial cache: cord-265230-ozyx8u64.txt plain text: cord-265230-ozyx8u64.txt item: #913 of 2876 id: cord-265262-r01u4jr6 author: Cannarella, Rossella title: Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients date: 2020-10-13 words: 8743 flesch: 42 summary: Its diagnosis is established when specific symptoms and signs of hypogonadism combine with low T levels. 7 Based on the Systemic effects of the hormonal treatment of male hypogonadism with preliminary indications for the management of COVID-19 patients hypogonadal-obesity-adipocytokine hypothesis, central obesity (often related to MetS and T2DM) associates with lower T levels due to the aromatization into estrogens occurring in adipocytes. keywords: cardiovascular; disease; hypogonadism; increase; levels; low; men; patients; pca; prostate; risk; studies; study; testosterone; therapy; trt cache: cord-265262-r01u4jr6.txt plain text: cord-265262-r01u4jr6.txt item: #914 of 2876 id: cord-265278-wf5pbvvt author: Fishman, Jay A. title: Case 29-2020: A 66-Year-Old Man with Fever and Shortness of Breath after Liver Transplantation date: 2020-09-17 words: 5278 flesch: 33 summary: Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series A novel coronavirus from patients with pneumonia in China A novel coronavirus emerging in Chinakey questions for impact assessment Novel Coronavirus-19 (COVID-19) in the immunocompromised transplant recipient: #Flatten-ingthecurve Focus on Case Records of the Massachusetts Gener al Hospital COVID toes Clinical features of patients infected with 2019 novel coronavirus in Wuhan COVID-19 in solid organ transplant recipients: a single-center case series from Spain Co-infections of SARS-CoV-2 with multiple common respiratory pathogens in infected patients Rates of co-infection between SARS-CoV-2 and other respiratory pathogens The immunocompromised transplant recipient and SARS-CoV-2 infection Management of patients on dialysis and with kidney transplant during SARS-COV-2 (COVID-19) pandemic In Brescia SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS COVID-19 in solid organ transplant recipients: initial report from the US epicenter Covid-19 and kidney transplantation Open-SAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients COVID-19 in solid organ transplant recipients: dynamics of disease progression and inflammatory markers in ICU and non-ICU admitted patients Multiorgan and renal tropism of SARS-CoV-2 Early description of coronavirus 2019 disease in kidney transplant recipients in New York Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases Clinical significance of human coronavirus in bronchoalveolar lavage samples from hematopoietic cell transplant recipients and patients with hematologic malignancies Prolonged shedding of human coronavirus in hematopoietic cell transplant recipients: risk factors and viral genome evolution The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Severe acute respiratory syndrome (SARS) in a liver transplant recipient and guidelines for donor SARS screening Emerging viral infections in transplant recipients MERS CoV infection in two renal transplant recipients: case report A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Communityacquired respiratory viruses in transplant patients: diversity, impact, unmet clinical needs Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia SARS-CoV-2 viral load in upper respiratory specimens of infected patients Epidemiology of SARS-CoV-2 emergence amidst community-acquired respiratory viruses Asymptomatic cases in a family cluster with SARS-CoV-2 infection Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility Diagnostic performance of CT and reverse transcriptase-polymerase chain reaction for coronavirus disease 2019: Research regarding the appropriate adjustment of exogenous immunosuppression for transplant patients, the timely start of antiviral therapies, and the deployment of antiinflammatory and immunomodulatory therapies in Covid-19 is in progress. keywords: acute; coronavirus; cov-2; covid-19; disease; infection; novel; organ; patients; recipients; renal; sars; transplant; transplantation cache: cord-265278-wf5pbvvt.txt plain text: cord-265278-wf5pbvvt.txt item: #915 of 2876 id: cord-265472-b1s4stvz author: Guimarães, Luísa Eça title: Vaccines, adjuvants and autoimmunity date: 2015-10-31 words: 14650 flesch: 37 summary: An experimental study in Brown Norway rats Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity Six revolutions in vaccinology From Pasteur to genomics: progress and challenges in infectious diseases Systems vaccinology Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century Studies of twins in vaccinology Vaccinomics current findings, challenges and novel approaches for vaccine development The HLA genomic loci map: expression, interaction, diversity and disease The link between genetic variation and variability in vaccine responses: systematic review and meta-analyses Development of polyarthritis after insertion of silicone breast implants followed by remission after implant removal in 2HLA-identical sisters bearing rheumatoid arthritis susceptibility genes Autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA) after quadrivalent human papillomavirus vaccination in Colombians: a call for personalised medicine Anticardiolipin and anti-beta(2) glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits Autoimmunity and hepatitis A vaccine in children Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome Vaccination-induced systemic autoimmunity in farmed Atlantic salmon Autoimmune response following annual influenza vaccination in 92 apparently healthy adults High non-specific T lymphocyte response to the adjuvanted H1N1 vaccine in comparison with the H1N1/H3N2/B-Brisbane vaccine without adjuvant Short and long-term effects of pandemic unadjuvanted influenza A(H1N1) pdm09 vaccine on clinical manifestations and autoantibody profile in primary Sjögren's syndrome Pneumococcal vaccination of patients with systemic lupus erythematosus: effects on generation of autoantibodies Immunogenicity and safety of a quadrivalent human papillomavirus vaccine in patients with systemic lupus erythematosus: a case-control study Safety and immunogenicity of the quadrivalent HPV vaccine in female systemic lupus erythematosus patients aged 12 to 26 years Anti-phospholipid antibodies following vaccination with recombinant hepatitis B vaccine Development of autoantibodies before the clinical onset of systemic lupus erythematosus Genetics and autoantibodies Silicone and autoimmunity Platinum in the environment: frequency of reactions to platinum-group elements in patients with dermatitis and urticaria Silicone and scleroderma revisited Rupture of silicone gel breast implants and symptoms of pain and fatigue This suggests that genomics is crucial in inter-individual variations in vaccine immune responses [82] . keywords: adjuvants; aluminum; anti; antibodies; arthritis; asia; autoimmune; autoimmunity; cases; cell; development; disease; hbv; hepatitis; hpv; human; infection; inflammatory; influenza; patients; response; risk; silicone; specific; studies; syndrome; vaccination; vaccine; virus cache: cord-265472-b1s4stvz.txt plain text: cord-265472-b1s4stvz.txt item: #916 of 2876 id: cord-265721-wmz3wywi author: Saini, Kamal S. title: Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy date: 2020-06-22 words: 1978 flesch: 24 summary: Small COVID-19 study shows encouraging results for EUSA Pharma Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19 Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19) SARS-COV-2 infection in cancer patients undergoing checkpoint blockade: clinical course and outcome COVID-19: risk for cytokine targeting in chronic inflammatory diseases? COVID-19 Treatment Guidelines Panel. In classic, cis-mediated signalling IL-6 binds to its membrane-bound receptor mIL-6R that is present on immune cells and modulates Janus kinases (JAKs) and signal transducer and activator of transcription 3 (STAT3); in trans-mediated signalling IL-6 binds to its soluble receptor sIL-6R, potentially impacting all cell surfaces; while in trans-mediated presentation, IL-6 binds to mIL-6R on immune cells leading to downstream T cell signalling precipitating acute respiratory distress syndrome. keywords: cancer; cells; covid-19; il-6; inflammation; patients; roche; treatment cache: cord-265721-wmz3wywi.txt plain text: cord-265721-wmz3wywi.txt item: #917 of 2876 id: cord-265799-qda5awuc author: Carothers, Chancey title: Acetylcysteine for the Treatment of Suspected Remdesivir‐Associated Acute Liver Failure in COVID‐19: A Case Series date: 2020-10-02 words: 3158 flesch: 42 summary: 15 In these cases, however, severe liver injury was usually associated with several months of tocilizumab therapy, where our patient only received a single dose prior to ALF. Drug-induced liver injury (DILI) is a serious adverse effect of medications that can range in presentation from mild transaminitis to fulminant liver failure and represents one of the most common causes of acute liver failure. By day on remdesivir, with a 200 mg IV loading dose and 100 mg IV daily for the next 4 days (finishing on hospital day 9). keywords: acetylcysteine; alf; day; liver; patient; remdesivir; use cache: cord-265799-qda5awuc.txt plain text: cord-265799-qda5awuc.txt item: #918 of 2876 id: cord-265812-1hcp36cw author: De Jong, Cornelis N. title: Etanercept for steroid-refractory acute graft-versus-host disease: A single center experience date: 2017-10-26 words: 3168 flesch: 49 summary: Patients with grade II aGVHD at diagnosis are significantly more likely to achieve a CR to initial treatment with high dose steroids as compared to patients with more advanced aGVHD Treatment response rate was 28% in etanercept treated patients. keywords: agvhd; days; etanercept; line; patients; treatment cache: cord-265812-1hcp36cw.txt plain text: cord-265812-1hcp36cw.txt item: #919 of 2876 id: cord-265818-wme1360n author: Cooley, Laura title: Trust and Communication: Responding to Uncertainty date: 2020-07-15 words: 563 flesch: 39 summary: A recent statement published by international leaders in the field of health communication science aptly emphasized the following: marginalized communities are under-represented in science and healthcare, which reduces effectiveness in both composing and disseminating key messages about risk and risk mitigation. My deepest appreciation for your continued dedication toward cultivating improved health care experiences, especially amid uncertain times. keywords: communication; health cache: cord-265818-wme1360n.txt plain text: cord-265818-wme1360n.txt item: #920 of 2876 id: cord-265848-afkeuwup author: None title: Chapter 2 Emergency Management of Poisoning date: 2007-12-31 words: 27431 flesch: 34 summary: small bowel obstruction secondary to amitriptyline overdose therapy Rectal ulcer with massive hemorrhage due to activated charcoal treatment in oral organophosphate poisoning Intestinal pseudo-obstruction following the use of enteral charcoal and sorbitol and mechanical ventilation with papaveretum sedation for theophylline poisoning Charcoal stercolith with intestinal perforation in a patient treated for amitriptyline ingestion Treatment with activated charcoal complicated by gastrointestinal obstruction requiring surgery Multiple doseactivated charcoal as a cause of acute appendicitis Small-bowel obstruction secondary to activated charcoal and adhesions Position statement: cathartics. In referred patients who have already been hospitalized elsewhere, ventricular arrhythmia may be due to hyperkalemia because renal failure may have ensued; in such patients, IV sodium bicarbonate, glucose/insulin, and, if necessary, calcium chloride administration may be warranted. keywords: acid; acute; administration; agents; blood; burns; calcium; case; charcoal; clearance; decontamination; dialysis; drug; effects; efficacy; elimination; extracorporeal; failure; gastrointestinal; glycol; hemodialysis; ingestion; intoxication; intubation; management; mdac; overdose; patient; peritoneal; poisoning; pressure; removal; skin; study; theophylline; therapy; toxicity; treatment; use; water cache: cord-265848-afkeuwup.txt plain text: cord-265848-afkeuwup.txt item: #921 of 2876 id: cord-265934-wjdxqj8h author: Singh, Amrita K. title: A Review of Telemedicine Applications in Otorhinolaryngology: Considerations During the Coronavirus Disease of 2019 Pandemic date: 2020-10-01 words: 4197 flesch: 33 summary: A retrospective analysis The value of CT scans in improving laryngoscopy in patients with laryngeal cancer Ultrasound imaging of the larynx and vocal folds: recent applications and developments Usefulness of ultrasonography in assessment of laryngeal carcinoma Laryngeal ultrasound as effective as CT scans for the diagnosis of various laryngeal lesions Telemedicine in laryngology: remote evaluation of voice disorders-setup and initial experience COVID-19 and rhinology: a look at the future Diagnostic accuracy of nasal endoscopy as compared to computed tomography in chronic Rhinosinusitis Comparative study of diagnostic nasal endoscopy and CT paranasal sinuses in diagnosing chronic rhinosinusitis endoscope-i: an innovation in mobile endoscopic technology transforming the delivery of patient care in otolaryngology Development of a microportable imaging system for otoscopy and nasoendoscopy evaluations Developing a synchronous otolaryngology telemedicine clinic: prospective study to assess fidelity and diagnostic concordance Utilization of a novel interactive mobile health platform to evaluate functional outcomes and pain following septoplasty and functional endoscopic sinus surgery change management in allergic rhinitis and asthma multimorbidity using mobile technology The Alaska experience using storeand-forward telemedicine for ENT care in Alaska Factors influencing patient satisfaction in plastic surgery: a Nationwide analysis Validation of videoconference with smartphones in telemedicine facial trauma care: analysis of concordance to on-site evaluation Telehealth in plastic surgery: a veterans affairs hospital perspective Patient satisfaction with an early smartphone-based cosmetic surgery postoperative follow-up Using telemedicine in otolaryngology Realtime telemedicine for paediatric ENT pre-admission screening Concordance between realtime telemedicine assessments and face-to-face consultations in paediatric otolaryngology Search terms were designed to identify studies which examined telemedicine use within ORL. keywords: care; evaluation; head; orl; patients; practice; study; surgery; telehealth; telemedicine; use cache: cord-265934-wjdxqj8h.txt plain text: cord-265934-wjdxqj8h.txt item: #922 of 2876 id: cord-265967-y4639p9m author: Rottenberg, Yakir title: Geriatric patient-centered care during the COVID-19: Provision of interactions vs. the imposition of isolation date: 2020-06-18 words: 459 flesch: 32 summary: Patients as well as family members and health care teams have to confront dilemmas and make difficult decisions such as whether to interrupt ongoing treatment due to possible infection or whether to allow family members to accompany older patients who cannot travel alone to treatment and feel too fragile and vulnerable to be alone. Toward defining hope for the science of positive human development A dialogue of depression and hope: Elderly patients diagnosed with cancer and their spousal caregivers The illness trajectory of elderly cancer patients across cultures: SIOG position paper Palliative care of cancer in the older patient keywords: cancer; patients cache: cord-265967-y4639p9m.txt plain text: cord-265967-y4639p9m.txt item: #923 of 2876 id: cord-266010-ectnfv5z author: Pediconi, Federica title: Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM date: 2020-07-13 words: 2739 flesch: 32 summary: The COVID-19 pandemic breast cancer consortium Recommendations for triage, prioritization and treatment of breast cancer patients during the COVID-19 pandemic Time to surgery and breast cancer survival in the United States Preoperative delays in the treatment of DCIS and the associated incidence of invasive breast cancer Oncology practice during the COVID-19 pandemic Managing cancer care during the COVID-19 pandemic: agility and collaboration toward a common goal Mammography screening reduces rates of advanced and fatal breast cancers: results in 549,091 women Association of screening and treatment with breast cancer mortality by molecular subtype in US women Breast cancer screening programs: does one risk fit all? Breast ultrasound: recommendations for information to women and referring physicians by the Diagnostic performance of MRI versus galactography in women with pathologic nipple discharge: a systematic review and meta-analysis Nipple discharge: the state of the art Breast MRI: EUSOBI recommendations for women's information Image-guided breast biopsy and localisation: recommendations for information to women and referring physicians by the European Society of Breast Imaging Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study 4th ESO-ESMO international consensus guidelines for advanced breast cancer Mammography: an update of the EUSOBI recommendations on information for women The requirements of a specialist breast centre Loneliness and social isolation as risk factors for mortality Depression in cancer: the many biobehavioral pathways driving tumor progression Emotional distress, brain functioning, and biobehavioral processes in cancer patients: a neuroimaging review and future directions Acknowledgments Open access funding provided by Università degli Studi di Milano within the CRUI-CARE Agreement. key: cord-266010-ectnfv5z authors: Pediconi, Federica; Galati, Francesca; Bernardi, Daniela; Belli, Paolo; Brancato, Beniamino; Calabrese, Massimo; Camera, Lucia; Carbonaro, Luca A.; Caumo, Francesca; Clauser, Paola; Girardi, Veronica; Iacconi, Chiara; Martincich, Laura; Panizza, Pietro; Petrillo, Antonella; Schiaffino, Simone; Tagliafico, Alberto; Trimboli, Rubina M.; Zuiani, Chiara; Sardanelli, Francesco; Montemezzi, Stefania title: Breast imaging and cancer diagnosis during the COVID-19 pandemic: recommendations from the Italian College of Breast Radiologists by SIRM date: 2020-07-13 journal: Radiol Med DOI: 10.1007/s11547-020-01254-3 sha: doc_id: 266010 cord_uid: ectnfv5z The Italian College of Breast Radiologists by the Italian Society of Medical Radiology (SIRM) provides recommendations for breast care provision and procedural prioritization during COVID-19 pandemic, being aware that medical decisions must be currently taken balancing patient’s individual and community safety: (1) patients having a scheduled or to-be-scheduled appointment for in-depth diagnostic breast imaging or needle biopsy should confirm the appointment or obtain a new one; (2) patients who have suspicious symptoms of breast cancer (in particular: new onset palpable nodule; skin or nipple retraction; orange peel skin; unilateral secretion from the nipple) should request non-deferrable tests at radiology services; (3) asymptomatic women performing annual mammographic follow-up after breast cancer treatment should preferably schedule the appointment within 1 year and 3 months from the previous check, compatibly with the local organizational conditions; (4) asymptomatic women who have not responded to the invitation for screening mammography after the onset of the pandemic or have been informed of the suspension of the screening activity should schedule the check preferably within 3 months from the date of the not performed check, compatibly with local organizational conditions. keywords: breast; cancer; covid-19; imaging; pandemic; patients; recommendations cache: cord-266010-ectnfv5z.txt plain text: cord-266010-ectnfv5z.txt item: #924 of 2876 id: cord-266079-nv28ppft author: Dai, Jinghong title: Corticosteroid treatment in severe COVID-19 pneumonia: two cases and literature review date: 2020-05-25 words: 2391 flesch: 38 summary: Ann Rheum Dis:annrheumdis-2020-217523 Use of tocilizumab for COVID-19 infection-induced cytokine release syndrome: a cautionary case report Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Tcell immunity of SARS-CoV: implications for vaccine development against MERS-CoV Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients First case of 2019 novel coronavirus in the United States Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Authors' contributions Jinghong Dai, Yajun Qian, and Hui Li were the patient's internal medicine physicians. the Guangzhou experience National Influenza Apdm09 Clinical Investigation Group of C (2017) Effect of low-to-moderate-dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Pathological findings of COVID-19 associated with acute respiratory distress syndrome Thoughts and practice on the treatment of severe and critical new coronavirus pneumonia COVID-19: a new virus, but a familiar receptor and cytokine release syndrome Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19 Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies Effective treatment of severe COVID-19 patients with tocilizumab Antirheumatic agents in covid-19: is IL-6 the right target? keywords: corticosteroids; covid-19; hrct; patients; pneumonia; treatment; use cache: cord-266079-nv28ppft.txt plain text: cord-266079-nv28ppft.txt item: #925 of 2876 id: cord-266105-8avkjc84 author: None title: cord-266105-8avkjc84 date: None words: 13081 flesch: 42 summary: Several strategies may help reduce the threat of AIV to equines, including reducing exposure of equines to poultry, birds, and other hosts of IAV, especially animals with clinical signs of influenza virus infection; monitoring AIV prevalence in domestic poultry around equines and routinely vaccinating domestic poultry with AIV vaccines; vaccinating susceptible equines with EI vaccines, especially farming equines in close contact with domestic poultry; and monitoring the prevalence of multiple AIV subtypes in equines, not merely that of those restricted to H3N8 subtype. 5 Low humidity and temperature increased the stability of influenza virus in aerosols and on surfaces. keywords: analysis; bacterial; cases; china; data; ecmo; epidemic; fig; genotype; hbv; hcv; hepatitis; hubei; human; infection; influenza; patients; pneumonia; sequences; sequencing; strains; study; subtype; transmission; virus cache: cord-266105-8avkjc84.txt plain text: cord-266105-8avkjc84.txt item: #926 of 2876 id: cord-266160-464v4g8o author: Bajaj, Jasmohan S title: Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort date: 2020-07-13 words: 3696 flesch: 44 summary: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures One world, one pandemic, many guidelines: management of liver diseases during COVID-19 Declining cirrhosis hospitalizations in the wake of the COVID-19 pandemic: a national cohort study Diagnosing and treating renal disease in cirrhotic patients Covid-19 and acute kidney injury in hospital: summary of NICE guidelines Functional decline in patients with cirrhosis awaiting liver transplantation: results from the functional assessment in liver transplantation (FrAILT) study Clinical course of acute-on-chronic liver failure syndrome and effects on prognosis Model for end-stage liver Disease-Lactate and prediction of inpatient mortality in patients with chronic liver disease Novelty in the gut: a systematic review and meta-analysis of the gastrointestinal manifestations of COVID-19 Gastrointestinal symptoms in patients with liver cirrhosis: associations with nutritional status and health-related quality of life We're not all in this together: on COVID-19, intersectionality, and structural inequality COVID-19: abnormal liver function tests Patient and public involvement Patients and/or the public were not involved in the design, conduct, reporting or dissemination plans of this research. Covid-19 in Critically Ill Patients in the Seattle Region -Case Series People of any age with underlying medical conditions Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: Preliminary results from an international registry COVID-19 in solid organ transplant recipients: initial report from the US EpiCenter Clinical characteristics and outcomes of COVID-19 among patients with pre-existing liver disease in United States: a multi-center research network study NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis Acute-On-Chronic liver failure: getting ready for prime time? keywords: cirrhosis; cirrhosis+covid-19; covid-19; group; liver; mortality; patients cache: cord-266160-464v4g8o.txt plain text: cord-266160-464v4g8o.txt item: #927 of 2876 id: cord-266214-l8pmhcd5 author: Wang, Xiaogang title: Management Strategies for Patients After CABG Surgery in the Outbreak of the COVID-19 Pandemic date: 2020-09-21 words: 2642 flesch: 40 summary: key: cord-266214-l8pmhcd5 authors: Wang, Xiaogang; Zhou, Yangzhao; Zhang, Xia; Li, Jianming; Zhou, Xinmin; Zhang, ZhiWei title: Management Strategies for Patients After CABG Surgery in the Outbreak of the COVID-19 Pandemic date: 2020-09-21 journal: Risk Manag Healthc Policy DOI: 10.2147/rmhp.s271133 sha: doc_id: 266214 cord_uid: l8pmhcd5 BACKGROUND: Patients with pre-existing cardiovascular disease may have a higher risk of infection of COVID-19 and worse outcomes than others. keywords: cabg; covid-19; disease; health; infection; patients; risk cache: cord-266214-l8pmhcd5.txt plain text: cord-266214-l8pmhcd5.txt item: #928 of 2876 id: cord-266255-898h9rl1 author: None title: Full Issue PDF date: 2020-08-31 words: 17697 flesch: 32 summary: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel ASE statement on protection of patients and echocardiography service providers during the 2019 novel coronavirus outbreak Focused cardiac ultrasonography Echocardiography in the time of COVID-19 Coronary CT angiography versus standard evaluation in acute chest pain Triple rule out versus coronary CT angiography in patients with acute chest pain results from the ACIC consortium Cardiac computed tomography in troponin-positive chest pain: sometimes the answer lies in the late iodine enhancement or extracellular volume fraction map Quadruple rule out with cardiac computed tomography in COVID-19 patient with equivocal acute coronary syndrome presentation Cardiovascular magnetic resonance in nonischemic myocardial inflammation: expert recommendations Early T1 myocardial MRI mapping: value in detecting myocardial hyperemia in acute myocarditis Guidance and best practices for nuclear cardiology laboratories during the coronavirus disease 2019 (COVID-19) pandemic: an information statement from ASNC and SNMMI 2020 Management of acute myocardial infarction during the COVID-19 pandemic Virtually perfect? key: cord-266255-898h9rl1 authors: nan title: Full Issue PDF date: 2020-08-31 journal: JACC: Cardiovascular Imaging DOI: 10.1016/s1936-878x(20)30581-7 sha: doc_id: 266255 cord_uid: 898h9rl1 nan studies in patients with mitral valve disease have identified atrial fibrillation (AF) as a risk factor (6, 7) , others have found pulmonary artery systolic pressures (PASPs) to be the most powerful predictor of TR progression (4) . keywords: analysis; artery; burden; cad; cardiac; coronary; covid-19; disease; echocardiography; figure; flow; heart; imaging; ischemic; left; lge; myocardial; patients; risk; scar; score; stenosis; study; table; tomography; ventricular; volume cache: cord-266255-898h9rl1.txt plain text: cord-266255-898h9rl1.txt item: #929 of 2876 id: cord-266294-ua22udlc author: Koch, Oliver title: 29 Antiviral drugs date: 2010-12-31 words: 10818 flesch: 39 summary: Metabolism The hemochromatosis gene polymorphism HFE 187C> G and possibly mitochondrial haplogroup J gave relative protection against lipoatrophy during antiretroviral drug therapy in a trial in which 96 patients were randomized to didanosine þ stavudine or zidovudine þ lamivudine, combined with efavirenz and/ or nelfinavir in AIDS Clinical Trials Group (ACTG) 384 sub-study A5005s (20 C ). The use of isoniazid preven tive therapy during antiretroviral drug therapy did not increase the risk of hepatotoxicity. keywords: abacavir; combination; dose; drug; efavirenz; hepatitis; hiv; lamivudine; nevirapine; patients; ribavirin; ritonavir; stavudine; study; tenofovir; therapy; tipranavir; treatment; women; zidovudine cache: cord-266294-ua22udlc.txt plain text: cord-266294-ua22udlc.txt item: #930 of 2876 id: cord-266429-0xaz8kbs author: Bader, Feras title: Heart failure and COVID-19 date: 2020-07-27 words: 5007 flesch: 30 summary: Heart failure patients on advanced therapies including those with heart transplantation will particularly benefit from involving the advanced heart failure team members in the overall management if they contract the virus. Moreover, heart failure patients on advanced therapies may also be on medications that interact with suggested COVID-19 regimens. keywords: cardiac; clinical; coronavirus; covid-19; disease; failure; heart; infection; pandemic; patients; risk cache: cord-266429-0xaz8kbs.txt plain text: cord-266429-0xaz8kbs.txt item: #931 of 2876 id: cord-266450-g9vihgbk author: Tran, Michael title: SARS-CoV-2 and pulmonary embolism: who stole the platelets? date: 2020-09-03 words: 1505 flesch: 33 summary: key: cord-266450-g9vihgbk authors: Tran, Michael; Sheth, Chirag; Bhandari, Rohan; Cameron, Scott J.; Hornacek, Deborah title: SARS-CoV-2 and pulmonary embolism: who stole the platelets? date: 2020-09-03 journal: Thromb J DOI: 10.1186/s12959-020-00229-8 sha: doc_id: 266450 cord_uid: g9vihgbk BACKGROUND: Patients infected with SARS-CoV-2 often develop venous and arterial thrombosis. CONCLUSIONS: Since excessive platelet activation and in situ thrombosis occur in HIT, this case underscores the need to consider that thrombocytopenia in patients with SARS-CoV-2—most of whom receive heparinoids—may be unrecognized HIT. keywords: heparin; hit; patient; platelet; thrombocytopenia cache: cord-266450-g9vihgbk.txt plain text: cord-266450-g9vihgbk.txt item: #932 of 2876 id: cord-266455-rbblg4pu author: Poole, Stephen title: Rapid syndromic molecular testing in pneumonia: The current landscape and future potential date: 2019-12-03 words: 4842 flesch: 28 summary: The unyvero P55 'sample-in, answer-out' pneumonia assay: a performance evaluation Respiratory multiplex polymerase chain reaction: an important diagnostic tool in immunocompromised patients Multiplex PCR performed of bronchoalveolar lavage fluid increases pathogen identification rate in critically ill patients with pneumonia: a pilot study Microbial etiologies of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia Geographical and temporal variation in the frequency and antimicrobial susceptibility of bacteria isolated from patients hospitalized with bacterial pneumonia: results from 20 years of the sentry antimicrobial surveillance program Viral infection in patients with severe pneumonia requiring intensive care unit admission Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (Re-sPOC): a pragmatic, open-label, randomised controlled trial Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza a H1N1pdm09 virus infection: a meta-analysis of individual participant data Early oseltamivir after hospital admission is associated with shortened hospitalization: a 5-Year analysis of oseltamivir timing and clinical outcomes National surveillance scheme for Legionnaires' disease in residents of England and Wales ReSyn-Plex: respiratory syndrome linked pathogens multiplex detection and characterization Biofire diagnostics -FilmArray The There is very little published data comparing different syndromic molecular pneumonia tests. keywords: antibiotics; care; clinical; culture; detection; panel; pathogens; patients; pneumonia; unyvero cache: cord-266455-rbblg4pu.txt plain text: cord-266455-rbblg4pu.txt item: #933 of 2876 id: cord-266456-10tjzqep author: Sadeghipour, Parham title: Management of ST‐segment‐elevation myocardial infarction during the coronavirus disease 2019 (COVID‐19) outbreak: Iranian“247” National Committee's position paper on primary percutaneous coronary intervention date: 2020-04-22 words: 1438 flesch: 38 summary: The management of antiplatelet therapy in acute coronary syndrome patients with thrombocytopenia: a clinical conundrum Guideline on the management of bleeding in patients on antithrombotic agents Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the Neurocritical Care Society and Society of Critical Care Medicine The Occupational Safety and Health Administration Getting to the heart of the matter: a review of drug interactions between HIV antiretrovirals and cardiology medications Resuscitation Council UK Statement on COVID-19 in relation to CPR and resuscitation in first aid and community settings Management of ST-segment-elevation myocardial infarction during the coronavirus disease 2019 (COVID-19) outbreak: Iranian247 National Committee's position paper on primary percutaneous coronary intervention The evolving pandemic of COVID-19 and interventional cardiology Catheterization laboratory considerations during the coronavirus (COVID-19) pandemic: from ACC's interventional council and SCAI Acute coronary syndromes in COVID-19: treatment considerations How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People's Hospital Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures Clinical features of patients infected with 2019 novel coronavirus in Wuhan Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): randomised trial Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. keywords: coronavirus; covid-19; infarction; management; patients; therapy cache: cord-266456-10tjzqep.txt plain text: cord-266456-10tjzqep.txt item: #934 of 2876 id: cord-266463-ci0g1dno author: Lopes, Renato D. title: Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-05-13 words: 5180 flesch: 41 summary: In a recent retrospective study of hospitalized COVID-19 patients, all-cause mortality was lower among patients on ACEI/ARB therapy when compared with those not using ACEI/ARBs. This is one of several questions facing physicians in the setting of COVID-19 and data are needed from randomized clinical trials like BRACE CORONA. keywords: acei; angiotensin; arb; clinical; covid-19; days; heart; patients; study; trial cache: cord-266463-ci0g1dno.txt plain text: cord-266463-ci0g1dno.txt item: #935 of 2876 id: cord-266469-n484zqq1 author: King, Michael J. title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system date: 2020-07-04 words: 4135 flesch: 39 summary: key: cord-266469-n484zqq1 authors: King, Michael J.; Lewis, Sara; El Homsi, Maria; Hernandez Meza, Gabriela; Bernheim, Adam; Jacobi, Adam; Chung, Michael; Taouli, Bachir title: Lung base CT findings in COVID-19 adult patients presenting with acute abdominal complaints: case series from a major New York City health system date: 2020-07-04 journal: To describe demographic, clinical, and lung base CT findings in COVID-19 patients presenting with abdominal complaints. keywords: base; clinical; covid-19; findings; lung; patients; study; symptoms cache: cord-266469-n484zqq1.txt plain text: cord-266469-n484zqq1.txt item: #936 of 2876 id: cord-266475-t04pukea author: Balestri, R. title: Late onset of acral necrosis after SARS‐CoV‐2 infection resolution date: 2020-05-26 words: 865 flesch: 36 summary: Authors have therefore suggested some pathogenetic mechanisms such as a delayed immune‐mediated reaction to the virus in genetically‐predisposed patients(1) or an early IFN‐I response in young patients, muting early viral replication but also inducing microangiopathic changes. Authors have therefore suggested some pathogenetic mechanisms such as a delayed immunemediated reaction to the virus in genetically-predisposed patients 1 or an early IFN-I response in young patients, muting early viral replication but also inducing microangiopathic changes. keywords: covid-19; patients cache: cord-266475-t04pukea.txt plain text: cord-266475-t04pukea.txt item: #937 of 2876 id: cord-266478-642m488a author: Gino, Bruno title: Automated Inflating Resuscitator (AIR): Design and Development of a 3D-Printed Ventilator Prototype and Corresponding Simulation Scenario Based on the Management of a Critical COVID-19 Patient date: 2020-07-11 words: 5442 flesch: 46 summary: Time is wasted adjusting AIR parameters after patient is connected. Referral hospitals are not receiving transfers due to the high influx of COVID-19 patients. keywords: air; bag; bvm; covid-19; oxygen; participants; patient; pressure; simulation; use; valve; ventilator cache: cord-266478-642m488a.txt plain text: cord-266478-642m488a.txt item: #938 of 2876 id: cord-266512-xh6zed03 author: Scala, Enrico title: Atopic statusprotects from severe complications of COVID‐19 date: 2020-08-16 words: 1302 flesch: 31 summary: Atopic patients are genetically predisposed to mount Th2 type immune-mediated responses; theseresponsesdo not imply the expression of the main cytokines involved in the ARDS. Interestingly, the prevalence of atopic patients in our population (10.7%) appeared lower than that in the age-matched general population, although recent epidemiological data on allergy in Italy are missing. keywords: atopic; disease; infection; patients cache: cord-266512-xh6zed03.txt plain text: cord-266512-xh6zed03.txt item: #939 of 2876 id: cord-266583-avhiqlgy author: Kim, Hae Jin title: Ultra-Low-Dose Chest CT in Patients with Neutropenic Fever and Hematologic Malignancy: Image Quality and Its Diagnostic Performance date: 2014-07-18 words: 4620 flesch: 59 summary: Management of febrile neutropenia: ESMO Clinical Practice Guidelines Pulmonary infiltrations in febrile patients with neutropenia: risk factors and outcome under empirical antimicrobial therapy in a randomized multicenter study Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography Reduced computed tomography radiation dose in HIV-related pneumonia: effect on diagnostic image quality Computed tomographic pulmonary angiography for diagnosis of invasive mold diseases in patients with hematological malignancies Computed tomography: an increasing source of radiation exposure Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study Radiation risks of medical imaging: separating fact from fantasy Strategies for CT radiation dose optimization Chest low-dose computed tomography in neutropenic acute myeloid leukaemia patients Low-dose spiral computed tomography of the thorax: comparison with the standard-dose technique Acute abdominal pain: value of non-contrast enhanced ultra-low-dose multi-detector row CT as a substitute for abdominal radiographs Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia Imaging of pulmonary viral pneumonia Pneumonia in neutropenic patients Radiation exposure at chest CT: a statement of the Fleischner Society Incidence and outcome of pneumonia in patients with acute leukemia receiving first induction therapy with anthracycline-containing regimens Infectious complications in the critically ill patient with cancer The aim of this study was to evaluate the image quality of ultra-low-dose computed tomography (ULDCT) and its diagnostic performance in making a specific diagnosis of pneumonia in febrile neutropenic patients with hematological malignancy. keywords: chest; dose; lung; neutropenic; patients; pneumonia; uldct cache: cord-266583-avhiqlgy.txt plain text: cord-266583-avhiqlgy.txt item: #940 of 2876 id: cord-266713-rghowch1 author: Reyes-Bueno, JA title: Case fatality of COVID-19 in patients with neurodegenerative dementia date: 2020-10-07 words: 2801 flesch: 47 summary: Our results suggest that case fatality of COVID-19 is significantly higher among patients with primary degenerative dementia than in other patients with similar mean ages and comorbidities. Our study suggests that the case fatality of COVID-19 is significantly higher in patients with primary degenerative dementia than among other patients with similar ages and comorbidities. keywords: case; covid-19; dementia; fatality; patients cache: cord-266713-rghowch1.txt plain text: cord-266713-rghowch1.txt item: #941 of 2876 id: cord-266722-qfn2dc1q author: Wormser, Gary P. title: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date: 1987-06-30 words: 5490 flesch: 30 summary: Transmission of disease is usually by person-toperson spread of respiratory droplets, although epidemics of streptococcal pharyngitis (both Groups A and G) have been traced to contaminated food or water. Cough or hoarseness is prevent or attenuate acute glomerulonephritis, not typically seen in streptococcal pharyngitis a complication that occurs more frequently and suggests a viral etiology. keywords: fever; flora; group; illness; infection; mononucleosis; patients; penicillin; pharyngitis; streptococcal; therapy; throat; treatment cache: cord-266722-qfn2dc1q.txt plain text: cord-266722-qfn2dc1q.txt item: #942 of 2876 id: cord-266730-mio282vy author: Li, Long‐quan title: COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis date: 2020-03-23 words: 1311 flesch: 46 summary: key: cord-266730-mio282vy authors: Li, Long‐quan; Huang, Tian; Wang, Yong‐qing; Wang, Zheng‐ping; Liang, Yuan; Huang, Tao‐bi; Zhang, Hui‐yun; Sun, Weiming; Wang, Yuping title: COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis date: 2020-03-23 journal: J Med Virol DOI: 10.1002/jmv.25757 sha: doc_id: 266730 cord_uid: mio282vy The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID‐19 patients for clinical help. The clinical data of COVID‐19 patients from December 2019 to February 2020 were retrieved from four databases. keywords: clinical; coronavirus; patients; rate cache: cord-266730-mio282vy.txt plain text: cord-266730-mio282vy.txt item: #943 of 2876 id: cord-266744-31p212aq author: Dick, Lachlan title: Changes in Emergency General Surgery During Covid-19 in Scotland: A Prospective Cohort Study date: 2020-08-28 words: 2254 flesch: 44 summary: Although not large in numbers, our experience of surgery in Covid-19 patients is comparable with the literature [7] . We demonstrate that the majority of emergency general surgical patients did not undergo Covid-19 testing; however, this may be due to initial limitations of testing. keywords: appendicitis; covid-19; emergency; patients; surgery cache: cord-266744-31p212aq.txt plain text: cord-266744-31p212aq.txt item: #944 of 2876 id: cord-266750-41gth6o0 author: Puzzitiello, Richard N. title: Inflammatory and Coagulative Considerations for the Management of Orthopaedic Trauma Patients With COVID-19: A Review of the Current Evidence and Our Surgical Experience date: 2020-05-14 words: 3746 flesch: 34 summary: The authors of this study also concluded that the characteristics and prognosis of COVID-19 patients with fractures tend to be more severe than those reported for COVID+ patients without fractures. The following precautions may be appropriate when dealing with unprecedented challenges associated with COVID-19 patients presenting with orthopaedic trauma injuries. keywords: covid-19; disease; fractures; hit; intramedullary; patients; response; trauma; treatment cache: cord-266750-41gth6o0.txt plain text: cord-266750-41gth6o0.txt item: #945 of 2876 id: cord-266775-4npowkkz author: Xu, Jun title: Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis date: 2005-10-15 words: 3454 flesch: 42 summary: This study provides direct evidence that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS. [5] reported that a CSF sample obtained from a 32-year-old woman with SARS tested positive for SARS coronavirus (SARS-CoV) by RT-PCR, indicating that SARS-CoV might cause an infection in the CNS of patients with SARS. keywords: brain; coronavirus; cov; infection; mig; patient; protein; sars; tissue cache: cord-266775-4npowkkz.txt plain text: cord-266775-4npowkkz.txt item: #946 of 2876 id: cord-266905-j9ljwqv0 author: Ecker, Jeffrey L. title: Laboring Alone?: Brief Thoughts on Ethics and Practical Answers During the COVID-19 Pandemic date: 2020-05-15 words: 3576 flesch: 47 summary: key: cord-266905-j9ljwqv0 authors: Ecker, Jeffrey L.; Minkoff, Howard L. title: Laboring Alone?: Brief Thoughts on Ethics and Practical Answers During the COVID-19 Pandemic date: 2020-05-15 journal: Am J Obstet Gynecol MFM DOI: 10.1016/j.ajogmf.2020.100141 sha: doc_id: 266905 cord_uid: j9ljwqv0 nan Condensation: To minimize risk of exposure to health care workers, some have proposed eliminating 4 spouses, partners and other visitors to support women during their labor and delivery. Those This piece will consider visitor policy from an ethical perspective. keywords: care; delivery; health; labor; patients; risk; visitors cache: cord-266905-j9ljwqv0.txt plain text: cord-266905-j9ljwqv0.txt item: #947 of 2876 id: cord-266932-567lbktm author: Escalard, Simon title: Early Brain Imaging Shows Increased Severity of Acute Ischemic Strokes With Large Vessel Occlusion in COVID-19 Patients date: 2020-08-19 words: 1439 flesch: 37 summary: Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in ST-segment elevation in patients with covid-19 -a case series Identification of imaging selection patterns in acute ischemic stroke patients and the influence on treatment and clinical trial enrollment decision making Collateral effect of covid-19 on stroke evaluation in the United States Current concepts in imaging and endovascular treatment of acute ischemic stroke: implications for the clinician While a higher severity of these patients could be expected from the addition of both respiratory and neurological injury, COVID-19 patients with strokes can present with mild or none respiratory symptoms. keywords: covid-19; occlusion; patients; stroke cache: cord-266932-567lbktm.txt plain text: cord-266932-567lbktm.txt item: #948 of 2876 id: cord-267020-4mpc246u author: Teixeira, Cassiano title: The medical decision-making process in the time of the coronavirus pandemic date: 2020 words: 2301 flesch: 33 summary: Such patients fit into two phenotypes that require distinct management and surveillance levels: patients with exacerbations of preexisting underlying diseases and patients with severe forms of viral pneumonia (respiratory failure, for example). (9) In the current context, many patients with respiratory symptoms arrive at emergency rooms and health clinics having been bombarded by constant media and health authority warnings related to the novel coronavirus pandemic. keywords: coronavirus; decision; making; novel; patients; process cache: cord-267020-4mpc246u.txt plain text: cord-267020-4mpc246u.txt item: #949 of 2876 id: cord-267041-i94lyfsh author: Ellner, Jerrold J. title: Management of acute and chronic respiratory tract infections date: 1988-09-16 words: 3291 flesch: 37 summary: Several prospective, placebo-controlled trials have demonstrated that treatment decreases duration of fever and other symptoms of sore throat due to streptococcal infection [l-4] . [6] showed that 24 percent of throat culture specimens failed to reveal streptococcal infection that was later identified when the patients' tonsils were removed and examined. keywords: bronchitis; infection; patients; percent; pharyngitis; pneumonia; treatment cache: cord-267041-i94lyfsh.txt plain text: cord-267041-i94lyfsh.txt item: #950 of 2876 id: cord-267124-8efdzlc0 author: Wichmann, Dominic title: Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study date: 2020-05-06 words: 4071 flesch: 45 summary: retrospective study Multiple roles of the coagulation protease cascade during virus infection Diagnosis, prevention, and treatment of thromboembolic complications in COVID-19: report of the National Institute for Public Health of the Netherlands Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past SARS-CoV-2 and viral sepsis: observations and hypotheses German recommendations for critically ill patients with COVID-19 The stimulation of thrombosis by hypoxia Histopathologic changes and SARS-CoV-2 immunostaining in the lung of a patient with COVID-19 Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer Effectiveness of convalescent plasma therapy in severe COVID-19 patients The characteristics of 50 hospitalized COVID-19 patients with and without ARDS Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up Current Author Addresses Dr. Becker: Department of Pulmonology and Internal Intensive Care, Asklepios Hospital Barmbek Dr. de Weerth: Department of Internal Medicine, Agaplesion Diakonie Hospital Author Contributions: Conception and design: D Provision of study materials or patients Standard weights for men and women (adopted from Molina and DiMaio [13, 14]), respectively, are as follows (the dependence of standard organ weights on body weight was not considered here): brain, 1401 g and 1233 g; heart, 331 g and 245 g; lung (right), 445 g and 340 g; lung (left), 395 g and 299 g; liver, 1561 g and 1288 g; kidney (right), 129 g and 108 g Figure 1 . To our knowledge, only 3 case reports have been published about COVID-19 patients who have undergone complete autopsy (7, 8) . keywords: autopsy; cases; cov-2; covid-19; death; findings; lung; patients; sars cache: cord-267124-8efdzlc0.txt plain text: cord-267124-8efdzlc0.txt item: #951 of 2876 id: cord-267132-nb0j6k3h author: Loveday, H.P. title: epic3: National Evidence-Based Guidelines for Preventing Healthcare-Associated Infections in NHS Hospitals in England date: 2013-12-10 words: 43426 flesch: 35 summary: Appropriateness of use of indwelling urinary catheters in patients admitted to the medical service Overuse of the indwelling urinary tract catheter in hospitalized medical patients Trends in catheter-associated urinary tract infections in adult intensive care units -United States Clinical and economic consequences of nosocomial catheter-related bacteriuria Recognition and prevention of healthcare-associated urinary tract infections in the intensive care unit Epidemiology of hospital-acquired urinary tract-related bloodstream infection at a university hospital Silver alloy vs. uncoated urinary catheters: a systematic review of the literature Catheter-associated urinary tract infections: new aspects of novel urinary catheters A review of strategies to decrease the duration of indwelling urethral catheters and potentially reduce the incidence of catheter-associated urinary tract infections Enhancing the safety of critically ill patients by reducing urinary and central venous catheterrelated infections Comparison of urethral reaction to full silicone, hydrogen-coated and siliconised latex catheters Effect of catheter material on the incidence of urethral strictures Randomised study of the effect of midnight versus 0600 removal of urinary catheters The association between indwelling urinary catheter use in the elderly and urinary tract infection in acute care Aiming to reduce catheter associated urinary tract infections (CAUTI) by adopting a checklist and bundle to achieve sustained system improvements Evidence for the use of silver-alloycoated urethral catheters The high impact actions for nursing and midwifery 5: protection from infection Preventing catheter-related bacteriuria: should we? How? Epidemiology of urinary tract infections: incidence, morbidity, and economic costs Guideline for prevention of catheter-associated urinary tract infections Computerbased order entry decreases duration of indwelling urinary catheterization in hospitalized patients Effect of nurse-led multidisciplinary rounds on reducing the unnecessary use of urinary catheterization in hospitalized patients Systematic review and S58 meta-analysis: reminder systems to reduce catheter-associated urinary tract infections and urinary catheter use in hospitalized patients Stop orders to reduce inappropriate urinary catheterization in hospitalized patients: a randomized controlled trial Reduction of urinary tract infection and antibiotic use after surgery: a controlled, prospective, before-after intervention study Interventions to minimise the initial use of indwelling urinary catheters in acute care: a systematic review Non-invasive measurement of bladder volume as an indication for bladder catheterization after orthopaedic surgery and its effect on urinary tract infections A collaborative, nurse-driven initiative to reduce hospital-acquired urinary tract infections Prevention of nosocomial catheter-associated urinary tract infections through computerized feedback to physicians and a nurse-directed protocol Continence clinic. keywords: access; alcohol; analysis; bsi; care; catheter; catheter insertion; contamination; control; devices; effectiveness; evidence; gloves; guidelines; hand; hand hygiene; healthcare; healthcare workers; hospital; hygiene; identià; infection; insertion; interventions; meta; microorganisms; number; patients; prevention; removal; review; risk; safety; sharps; signià; site; skin; studies; study; systematic; term; use; venous; workers cache: cord-267132-nb0j6k3h.txt plain text: cord-267132-nb0j6k3h.txt item: #952 of 2876 id: cord-267142-ys7z7j8j author: Cheema, Marvi title: Keratoconjunctivitis as the initial medical presentation of the novel coronavirus disease 2019 (COVID-19) date: 2020-04-02 words: 2468 flesch: 41 summary: Given this, eye care professionals, most notably ophthalmologists, may be the first point of contact in the health care field for patients with possible COVID-19, before the onset of characteristic respiratory symptoms. The case emphasizes the importance for eye care professionals to remain vigilant and consider SARS-CoV-2 as the causative agent in patients presenting with viral conjunctivitis, particularly in high-risk patients with travel to areas of active transmission of the virus. keywords: care; case; coronavirus; covid-19; eye; health; patient cache: cord-267142-ys7z7j8j.txt plain text: cord-267142-ys7z7j8j.txt item: #953 of 2876 id: cord-267287-qodj254z author: Pintado, Juan F. title: How COVID-19 has affected Emergent Visits to a Latin-American Trauma Department: Experience at a Peruvian National Trauma Referral Center date: 2020-11-03 words: 3665 flesch: 40 summary: The protocol for COVID-19 positive patients with indication for an orthopedic procedure has been resume in Table 1 . Protocol for COVID-19 positive patients with indication for an orthopedic procedure during the government-mandated nationwide lockdown for COVID-19 in Peru. keywords: covid-19; emergency; fractures; hospital; number; pandemic; patients; trauma cache: cord-267287-qodj254z.txt plain text: cord-267287-qodj254z.txt item: #954 of 2876 id: cord-267300-zbipv9er author: Alalwan, Adel A title: A Hemodialysis Patient with Severe COVID-19 Pneumonia date: 2020-05-06 words: 2355 flesch: 45 summary: Although the majority of COVID-19 pneumonia patients have normal serum procalcitonin (PCT), the patient had slightly elevated PCT on admission. Common abnormal radiographic findings in the chest x-rays of COVID-19 pneumonia patients were consolidation and ground-glass opacities, with bilateral, peripheral, and lower lung zone distributions. keywords: covid-19; disease; esrd; hemodialysis; patient; pneumonia; treatment cache: cord-267300-zbipv9er.txt plain text: cord-267300-zbipv9er.txt item: #955 of 2876 id: cord-267357-7aap2cte author: Elston, Dirk M. title: The coronavirus (COVID-19) epidemic and patient safety date: 2020-02-16 words: 605 flesch: 30 summary: key: cord-267357-7aap2cte authors: Elston, Dirk M. title: The coronavirus (COVID-19) epidemic and patient safety date: 2020-02-16 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.02.031 sha: doc_id: 267357 cord_uid: 7aap2cte nan The coronavirus (COVID-19) epidemic and patient safety Dirk M. Elston, MD Charleston, South Carolina I n this issue of the JAAD, Chen et al 1 discuss patient safety measures in a Chinese dermatology clinic during the coronavirus outbreak (2019-nCoV acute respiratory disease), including patient screening, respiratory precautions, and telemedicine consultations. Substandard infection control, including errors in equipment sterilization and standard precautions, contributed to the outbreak. Prevention of transmission of blood-borne infections deserves special mention, and readers should review the JAAD continuing medical education articles that focused on patient safety and blood-borne pathogens (https://www.jaad. org/article/S0190-9622(09)00603-3/fulltext and https://www.jaad.org/article/S0190-9622(09)00602-1/fulltext). keywords: coronavirus; patient; safety cache: cord-267357-7aap2cte.txt plain text: cord-267357-7aap2cte.txt item: #956 of 2876 id: cord-267402-kca05rvz author: South, Kieron title: Preceding infection and risk of stroke: An old concept revived by the COVID-19 pandemic date: 2020-07-24 words: 6252 flesch: 31 summary: medRxiv, Epub ahead of print 2020 Dysregulation of Immune Response in Patients With Coronavirus Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome Clinical progression and cytokine profiles of middle east respiratory syndrome coronavirus infection Inflammatory cytokines and ischemic stroke risk: the REGARDS cohort Systemic infections cause exaggerated local inflammation in atherosclerotic coronary arteries: clues to the triggering effect of acute infections on acute coronary syndromes Inflammation and plaque vulnerability Infection and atherosclerosis development The role of immune cells in atrial fibrillation The role of infection in the development of non-valvular atrial fibrillation: up-regulation of Toll-like receptor 2 expression levels on monocytes Pandemic H1N1 influenza infection and vascular thrombosis Pulmonary artery thrombosis in a patient with severe acute respiratory syndrome Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Hypercoagulability of COVID-19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in C-reactive protein levels in the early stage of COVID-19 Procoagulant soluble tissue factor is released from endothelial cells in response to inflammatory cytokines The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury Thrombinactivatable fibrinolysis inhibitor and protein C inhibitor in interstitial lung disease Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells Inflammationassociated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor Acute respiratory tract infection leads to procoagulant changes in human subjects Analysis of thrombotic factors in severe acute respiratory syndrome (SARS) patients Involvement of ADAMTS13 and von Willebrand factor in thromboembolic events in patients infected with SARS-CoV-2 Epub ahead of print 23 ADAMTS13 activity, von Willebrand factor, factor VIII and D-dimers in COVID-19 inpatients High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIVinfected patients Thrombocytopenia and its association with mortality in patients with COVID-19 Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With COVID-19 Platelets and infection -an emerging role of platelets in viral infection Neutrophil extracellular traps in COVID-19 ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice Hypercoagulability is a stronger risk factor for ischaemic stroke than for myocardial infarction: a systematic review Severe COVID-19 infection associated with endothelial activation Electron microscopy of SARS-CoV-2: a challenging task -authors' reply Aberrant coagulation causes a hyper-inflammatory response in severe influenza pneumonia Immunopathogenesis of coronavirus infections: implications for SARS Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease Central nervous system manifestations of COVID-19: a systematic review Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Central nervous system infections and stroke -a population-based analysis The neutrophil in vascular inflammation COVID-19 and cardiovascular disease Defining causality in COVID-19 and neurological disorders Thromboprophylaxis in intensive care unit patients: a literature review Risk of Ischemic Stroke in Patients with Covid-19 versus Patients with Influenza Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis Coronavirus Infections and Type 2 Diabetes-Shared Pathways with Therapeutic Implications Obesity and impaired metabolic health in patients with COVID-19 Factors associated with death or hospitalization due to pandemic 2009 influenza A(H1N1) infection in California Increased risk of influenza among vaccinated adults who are obese Obesity, inflammation, and insulin resistance -a mini-review Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation Chest CT findings in cases from the cruise ship 'Diamond Princess' with coronavirus disease 2019 (COVID-19) Association between influenza vaccination and reduced risk of brain infarction Management of acute ischemic stroke in patients with COVID-19 infection: report of an international panel There is clear evidence, from post-mortem lung pathology, of extensive thrombosis in the alveolar capillaries and small vessels in response to COVID-19 infection. keywords: acute; cells; coronavirus; cov-2; covid-19; disease; factor; incidence; infection; patients; risk; sars; stroke cache: cord-267402-kca05rvz.txt plain text: cord-267402-kca05rvz.txt item: #957 of 2876 id: cord-267525-tg4uwent author: Rezaei, Shawheen J. title: Neuromyelitis optica practice and prescribing changes in the setting of Covid19: A survey of neurologists date: 2020-07-11 words: 2991 flesch: 41 summary: Neurologists responded that they would like to see the following changes to NMO patient care: increased access to home infusions, updated guidelines on how to best treat NMO patients during the crisis, and prioritization of these patients for social services. Although evidence has not been found to indicate that Covid19 directly affects the disease course in NMO or that NMO treatment causes increased susceptibility to Covid19 infection, this perceived high risk for NMO patients during the pandemic largely stems from the impact of immunosuppression on the overall risk of infection and the need for safety monitoring for the available therapies. keywords: covid19; neurologists; nmo; pandemic; patients; study; treatment cache: cord-267525-tg4uwent.txt plain text: cord-267525-tg4uwent.txt item: #958 of 2876 id: cord-267621-oc8bw7ft author: Kevorkian, Jean-Philippe title: Early short-course corticosteroids and furosemide combination to treat non-critically ill COVID-19 patients: An observational cohort study date: 2020-09-01 words: 1205 flesch: 29 summary: Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial COVID-19: consider cytokine storm syndromes and immunosuppression Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis Fluid management in ARDS Dexamethasone in hospitalized patients with COVID-19-Preliminary Report Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-19 Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study COVID-19 in patients with heart failure: the new and the old epidemic Troponin Ic high-sensitivity (ng/mL) 18 11 In COVID-19 patients, viral shedding is elevated early then declines. keywords: corticosteroids; covid-19; furosemide; patients cache: cord-267621-oc8bw7ft.txt plain text: cord-267621-oc8bw7ft.txt item: #959 of 2876 id: cord-267788-ukz2wz4a author: Jaffe, Allan S title: Myocardial injury in severe COVID-19 infection date: 2020-06-07 words: 1910 flesch: 44 summary: Increases in cTn may also reflect acute myocardial injury. When myocardial ischaemia is not present, the proper term for the increased cTn even with a rising pattern is 'acute myocardial injury' as per the Universal Definition of Myocardial Infarction. keywords: covid-19; ctni; injury; patients; troponin cache: cord-267788-ukz2wz4a.txt plain text: cord-267788-ukz2wz4a.txt item: #960 of 2876 id: cord-267947-dnv2xl0h author: Gornet, Jean-Marc title: What do surgeons need to know about the digestive disorders and paraclinical abnormalities induced by COVID-19? date: 2020-04-24 words: 3752 flesch: 37 summary: Even though these data remain highly fragmentary, digestive cancer patients are probably significantly at risk of COVID-19 infection, particularly those currently undergoing intravenous chemotherapy, who risk contamination during their care pathway (repeated hospitalizations, imaging examinations and blood tests in medicalized structures…). It should nonetheless be noted that notwithstanding the presence of the ACE2 receptor in the cholangiocytes, the patients did not present with intrahepatic cholestasis, which is associated with the virus (absence of elevated Gamma Gt and PAL in study patients without preexisting liver disease). keywords: covid-19; data; diarrhea; digestive; infection; patients; risk; symptoms cache: cord-267947-dnv2xl0h.txt plain text: cord-267947-dnv2xl0h.txt item: #961 of 2876 id: cord-268049-7xqln70d author: Montrief, Tim title: COVID-19 respiratory support in the emergency department setting date: 2020-08-08 words: 5201 flesch: 38 summary: [24] [25] [26] HFNC is an emerging support modality for patients with COVID-19 and has been associated with increased survival in COVID-19 patients when compared to either NIV or invasive mechanical ventilation. 38 International guidelines on the use of NIV for COVID-19 patients vary, with many guidelines recommending against the routine use of NIV due to increased risk of virus aerosolization and unproven utility in patients with ARDS. keywords: airway; covid-19; failure; intubation; management; niv; oxygen; patients; risk; sars cache: cord-268049-7xqln70d.txt plain text: cord-268049-7xqln70d.txt item: #962 of 2876 id: cord-268140-s5lailkp author: Atal, Shubham title: IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? date: 2020-06-13 words: 5184 flesch: 36 summary: Furthermore, tissue necrosis and interstitial macrophages and monocyte infiltrations in the lungs, heart and gastrointestinal mucosa have been demonstrated in postmortem pathology in COVID-19 patients [25, 31] . It has been proposed that early diagnosis of CRS in COVID-19 patients through screening tools like the H-score used for HLH, and prompt immunomodulation with IL-6 inhibitors may be beneficial, as in HLH [37] . keywords: coronavirus; covid-19; drugs; evidence; il-6; inhibitors; lung; patients; sars; tocilizumab; treatment cache: cord-268140-s5lailkp.txt plain text: cord-268140-s5lailkp.txt item: #963 of 2876 id: cord-268155-b8lqo52f author: Farrugia, Albert title: Plasma from donors convalescent from SARS-CoV-2 infection – A matter of priorities date: 2020-06-12 words: 445 flesch: 20 summary: Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Polyclonal immunoglobulins and hyperimmune globulins in prevention and management of infectious diseases Global Plasma Leaders Collaborate to Accelerate Development of Potential COVID-19 Hyperimmune Therapy Donor centers for convalescent plasma The Separation of the Antibodies, Isoagglutinins, Prothrombin, Plasminogen and β1-Lipoprotein into Subfractions of Human Plasma Purification of human immunoglobulin G: a new approach to plasma fractionation Optimised affinity purification of polyclonal antibodies from hyper immunised ovine serum using a synthetic Protein A adsorbent, MAbsorbent® A2P Chloroquine diphosphate in two different dosages as adjunctive therapy of hospitalized patients with severe respiratory syndrome in the context of coronavirus (SARS-CoV-2) infection: Preliminary safety results of a randomized, double-blinded, phase IIb clinical trial (CloroCovid-19 Study). Convalescent plasma harvested from voluntary donors in state blood services is at risk of being deflected from therapeutic use through preferential patient allocation to clinical trials for other Covid-19 therapies funded by large pharmaceutical companies. keywords: convalescent; plasma cache: cord-268155-b8lqo52f.txt plain text: cord-268155-b8lqo52f.txt item: #964 of 2876 id: cord-268168-yzvag38x author: Scolnick, Barbara title: Remission from Chronic Anorexia Nervosa With Ketogenic Diet and Ketamine: Case Report date: 2020-07-30 words: 4655 flesch: 48 summary: Ketones are produced in the liver whenever fat metabolism increases over carbohydrate metabolism; such as fasting, post-exercise, neonatal period, and KG diet, as well as during pathological states such as starvation or uncontrolled diabetes mellitus (9) . KG diets for AN have been roundly dismissed by eating disorder experts, and with the exception of an early study in 1998, ketamine has not been reported as effective in AN. keywords: anorexia; diet; infusions; ketamine; ketogenic; nervosa; patient; treatment; weight cache: cord-268168-yzvag38x.txt plain text: cord-268168-yzvag38x.txt item: #965 of 2876 id: cord-268211-egy8rgtl author: Barrasa, Helena title: SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria date: 2020-04-09 words: 2691 flesch: 47 summary: Reports describing ICU patients with SARS-CoV-2 out of China are still limited [3, 4] . Early on this disease, non-intubated patients may benefit from prone position before intubation. keywords: cov-2; icu; intubation; mortality; non; patients; sars; ventilation cache: cord-268211-egy8rgtl.txt plain text: cord-268211-egy8rgtl.txt item: #966 of 2876 id: cord-268252-6g0vbd08 author: Richards, Wayne title: Being a dentist in the pandemic date: 2020-06-26 words: 527 flesch: 46 summary: The paper describes the assimilation of available information regarding 2019-nCoV at the time of writing. Practice point • Cross infection protocols will prove essential to protect dentists, patients and society at large in the current pandemic. keywords: authors; infection cache: cord-268252-6g0vbd08.txt plain text: cord-268252-6g0vbd08.txt item: #967 of 2876 id: cord-268254-1mg7a17c author: Liu, Li title: High neutralizing antibody titer in intensive care unit patients with COVID-19 date: 2020-07-20 words: 3480 flesch: 49 summary: Furthermore, by comparing ICU and non-ICU patients, we have shown that NAb response rose significantly earlier and to a much greater extent in severe patients than in mild patients. Furthermore, NAb titer increased significantly at earlier infection stages among ICU patients than among non-ICU patients. keywords: cov-2; covid-19; disease; icu; nab; patients; response; sars; titer cache: cord-268254-1mg7a17c.txt plain text: cord-268254-1mg7a17c.txt item: #968 of 2876 id: cord-268324-86a0n0dc author: Charitos, Ioannis A title: Special features of SARS-CoV-2 in daily practice date: 2020-09-26 words: 6120 flesch: 38 summary: Current studies are investigating the relationship between different variables and the risk of death of COVID-19 patients hospitalized for pneumonia. COVID-19 patients are often very complex and require a multidisciplinary medical team which includes at least the following specialists: emergency doctor, pulmonologist, infectious disease specialist, critical care physician, and medical laboratory technician [72] keywords: cases; coronavirus; cov-2; covid-19; disease; health; infection; management; patients; pneumonia; risk; sars; symptoms; treatment; use; world cache: cord-268324-86a0n0dc.txt plain text: cord-268324-86a0n0dc.txt item: #969 of 2876 id: cord-268326-sbz3uk5h author: Bonam, Srinivasa Reddy title: Lysosomes as a therapeutic target date: 2019-09-02 words: 17914 flesch: 25 summary: There is an obvious requirement for safety, to ensure that a drug used as a lysosome modu lator for a particular type of lysosomal disease does not increase vulnerability to another disease. Intracellular distribution patterns of enzymes in rat-liver tissue Lysosomal membrane permeabilization and cell death Signals from the lysosome: a control centre for cellular clearance and energy metabolism This article is an encyclopaedia of lysosomal physiology The lysosome as a regulatory hub Lysosome positioning coordinates mTORC1 activity and autophagy The coming of age of chaperone-mediated autophagy Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function Lysosomal disorders: from storage to cellular damage Enzyme replacement therapy for lysosomal diseases: lessons from 20 years of experience and remaining challenges Chemical modulators of autophagy as biological probes and potential therapeutics Pharmacological regulators of autophagy and their link with modulators of lupus disease Mechanism and medical implications of mammalian autophagy Autophagy: a new concept in autoimmunity regulation and a novel therapeutic option Critical functions of the lysosome in cancer biology The lysosome as a cellular centre for signalling, metabolism and quality control CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis The mannose 6-phosphate receptor and the biogenesis of lysosomes Role of LIMP-2 in the intracellular trafficking of β-glucosidase in different human cellular models Lysosomal acidification mechanisms Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis MCOLN1 is a ROS sensor in lysosomes that regulates autophagy Lysosomal storage diseases: from pathophysiology to therapy keywords: accumulation; activity; autoimmune; autophagy; cathepsin; cells; chaperone; cma; degradation; disease; disorders; dysfunction; enzyme; example; expression; function; gaucher; inflammatory; inhibitor; lsds; lupus; lysosomal; lysosomes; membrane; mice; molecules; pathways; patients; peptide; potential; processes; protein; regulation; role; storage; table; target; tfeb; type cache: cord-268326-sbz3uk5h.txt plain text: cord-268326-sbz3uk5h.txt item: #970 of 2876 id: cord-268347-xz6fptol author: Kow, Chia Siang title: Pharmacotherapeutic considerations for systemic rheumatic diseases amid the COVID-19 pandemic: more questions than answers date: 2020-08-16 words: 2668 flesch: 25 summary: Furthermore, a nationwide study in Russia found that the prevalence of systemic rheumatic diseases among COVID-19 patients admitted to ICUs with a severe course of COVID-19 was low (10 of 902 patients; 1.1%) and similar to that of the general Russian population [6] . On the other hand, IL-6 receptor inhibitors (e.g. tocilizumab and sarilumab) may be continued in selected patients, particularly those in whom cytokine storm syndrome is impending, preferably in clinical trial settings, given the potential benefit of IL-6 inhibitors in COVID-19 patients who develop an intense inflammatory state; however, conclusive evidence on their efficacy remains to be elucidated keywords: agents; arthritis; covid-19; disease; patients; risk cache: cord-268347-xz6fptol.txt plain text: cord-268347-xz6fptol.txt item: #971 of 2876 id: cord-268455-btuzihsy author: de Santiago, Javier title: COVID-19: gynecologic cancer surgery at a single center in Madrid date: 2020-07-07 words: 2970 flesch: 42 summary: MD Anderson Cancer Center Madrid, given its characteristics and focus on the treatment of cancer patients, can be comparatively considered as a relatively COVID-19 free center. Although there are no specific reports in cancer patients regarding the incidence of COVID-19, they are considered high risk due to older age, increased incidence of comorbidities, and lower immunity. keywords: cancer; covid-19; infection; pandemic; patients; study; surgery cache: cord-268455-btuzihsy.txt plain text: cord-268455-btuzihsy.txt item: #972 of 2876 id: cord-268531-igjeai8c author: Zerah, Lorène title: Clinical Characteristics and Outcomes of 821 Older Patients With SARS-Cov-2 Infection Admitted to Acute Care Geriatric Wards: A Multicenter Retrospective Cohort Study date: 2020-08-26 words: 4036 flesch: 42 summary: The mortality rate has been reported to be greater in patients with comorbidities, particularly diabetes, hypertension, obesity, and cardiovascular disease, and in older patients (5-10). Only 2 cohort studies of hospitalized patients, defined as geriatric, have been published but they included patients younger than 70 years and with few very old patients (11, 12) . keywords: characteristics; cohort; covid-19; disease; geriatric; hospital; mortality; patients; study cache: cord-268531-igjeai8c.txt plain text: cord-268531-igjeai8c.txt item: #973 of 2876 id: cord-268540-wrjzr3ws author: Park, You Jeong title: Fighting the War Against COVID-19 via Cell-Based Regenerative Medicine: Lessons Learned from 1918 Spanish Flu and Other Previous Pandemics date: 2020-08-13 words: 16386 flesch: 42 summary: Clinical improvement following stem cell treatment will be assessed via frequency of adverse incidents, mortality rate, the number of ventilator and ICU free days, total hospital and ICU days, and improvement in oxygenation. The potent binding of SP to ACE2 and subsequent cellular infection may explain the prevalence of respiratory symptoms in COVID-19 patients. keywords: ace2; acute; cells; convalescent; coronavirus; cov-2; covid-19; covid-19 patients; disease; human; immune; infection; lung; mesenchymal; mscs; patients; plasma; sars; stem; stem cells; symptoms; syndrome; therapy; treatment; vaccine; virus cache: cord-268540-wrjzr3ws.txt plain text: cord-268540-wrjzr3ws.txt item: #974 of 2876 id: cord-268561-vq1uhj5i author: da Silva, Severino Jefferson Ribeiro title: Clinical and Laboratory Diagnosis of SARS-CoV-2, the Virus Causing COVID-19 date: 2020-08-04 words: 9935 flesch: 36 summary: Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein Novel antibody epitopes dominate the antigenicity of spike glycoprotein in SARS-CoV-2 compared to SARS-CoV Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2 Analysis of the first cluster of cases in a family of novel coronavirus pneumonia in Gansu Province Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19) SARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Test performance evaluation of SARS-CoV-2 serological assays Diagnostic performance of 7 rapid IgG/IgM antibody tests and the Euroimmun IgA/IgG ELISA in COVID-19 patients Development and Clinical Application of A Rapid IgM-IgG Combined Antibody Test for SARS-CoV-2 Infection Diagnosis Clinical Performance of Two SARS-CoV-2 Serologic Assays Serological immunochromatographic approach in diagnosis with SARS-CoV-2 infected COVID-19 patients Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Clinical performance of different SARS-CoV-2 IgG antibody tests Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2 Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV Evaluation of novel antigen-based rapid detection test for the diagnosis of SARS-CoV-2 in respiratory samples Evaluation of rapid antigen test for detection of SARS-CoV-2 virus Development of a Portable, Ultra-Rapid and Ultra-Sensitive Cell-Based Biosensor for the Direct Detection of the SARS-CoV-2 S1 Microfluidic Immunoassays for Sensitive and Simultaneous Detection of IgG/IgM/Antigen of SARS-CoV-2 within 15 min 2020) In addition, several studies have been used to evaluate the clinical sensitivity of serological tests with COVID-19 patient samples collected on different days after the onset of symptoms. keywords: assays; cases; clinical; coronavirus; cov-2; covid-19; days; detection; diagnosis; disease; genome; infection; novel; patients; results; samples; sars; study; symptoms; tests cache: cord-268561-vq1uhj5i.txt plain text: cord-268561-vq1uhj5i.txt item: #975 of 2876 id: cord-268617-1t7yaoct author: Ismaili, Nabil title: COVID-19 and Gynecological Cancers: A Summary of International Recommendations date: 2020-08-31 words: 3986 flesch: 38 summary: Cancer patients are more susceptible to develop an infection than people without cancer because of their immunosuppression caused by the disease and treatments (surgery and chemotherapy). Cancer patients are more susceptible to develop an infection than people without cancer because of their immunosuppression caused by the disease and treatments, such as chemotherapy and/or surgery. keywords: cancer; chemotherapy; covid-19; disease; patients; risk; stage; surgery; treatment cache: cord-268617-1t7yaoct.txt plain text: cord-268617-1t7yaoct.txt item: #976 of 2876 id: cord-268632-p1rsz8fk author: Tartari, Federico title: Herpes zoster in COVID‐19‐positive patients date: 2020-06-12 words: 370 flesch: 46 summary: Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia Decreased absolute numbers of CD3+ T cells and CD8+ T cells during aging in herpes zoster patients The clinical scenario differs with most patients only needing supportive care, while others require admission to an intensive care unit (ICU) for invasive mechanical ventilation. keywords: covid-19; patients cache: cord-268632-p1rsz8fk.txt plain text: cord-268632-p1rsz8fk.txt item: #977 of 2876 id: cord-268843-zml9lbve author: Cuvelier, Geoffrey D.E. title: Clinical presentation, immunologic features, and hematopoietic stem cell transplant outcomes for IKBKB immune deficiency date: 2018-10-31 words: 5833 flesch: 35 summary: Failure to correct non-immune cells with HSCT could explain the ongoing infectious complications seen years after an otherwise apparently successful, lymphoid engrafted transplant in IKBKB immune deficiency. This series presents the clinical features, immunologic presentation, and HSCT outcomes for the largest cohort of IKBKB immune deficiency patients published to date. keywords: cells; deficiency; hsct; ikbkb; immunodeficiency; infections; mutation; n =; nemo; patients; post; years cache: cord-268843-zml9lbve.txt plain text: cord-268843-zml9lbve.txt item: #978 of 2876 id: cord-268879-ajd7ofc8 author: Hui, David S. title: Contemporary Concise Review 2018: Respiratory infections and tuberculosis date: 2019-03-30 words: 3697 flesch: 32 summary: 25 Social inequities continue to hamper TB control in many parts of the world, and major gaps remain in reaching, diagnosing and effectively treating TB patients, especially in resource-limited settings. In another longitudinal study from the same locality, 42 metformin users were associated with 44% reduction in mortality during TB treatment despite their higher haemoglobin A1c level. keywords: cap; days; drug; infection; influenza; patients; respiratory; risk; treatment; tuberculosis cache: cord-268879-ajd7ofc8.txt plain text: cord-268879-ajd7ofc8.txt item: #979 of 2876 id: cord-268886-mpceglk1 author: Bourne, T. title: ISUOG Consensus Statement on rationalization of gynecological ultrasound services in context of SARS‐CoV‐2 date: 2020-04-08 words: 3088 flesch: 42 summary: While the provision of ultrasound is an essential service and all individuals with gynecological complaints deserve high-quality investigation, the current coronavirus disease 2019 (COVID-19) pandemic warrants triaging of referrals for gynecological ultrasound assessment. If there is suspicion of a procedure-related complication (e.g. perforation) or the patient experiences an adverse event post-procedure, such as after placement of an intrauterine contraceptive device (IUCD) (e.g. severe pain, bleeding, infection), gynecological ultrasound should be offered immediately. keywords: covid-19; evaluation; ovarian; pandemic; patients; symptoms; ultrasound cache: cord-268886-mpceglk1.txt plain text: cord-268886-mpceglk1.txt item: #980 of 2876 id: cord-268939-ws74xprt author: Ozoner, Baris title: Neurosurgery Practice During Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-28 words: 5145 flesch: 41 summary: Screening is crucial in all patients since the surgical outcome is highly mortal in COVID-19 patients. In this way, hub hospitals are available to manage neurosurgical emergencies, whereas spoke hospitals concentrate on COVID-19 patients. keywords: cases; china; coronavirus; cov-2; covid-19; disease; level; medical; neurosurgery; pandemic; patients; practice; sars cache: cord-268939-ws74xprt.txt plain text: cord-268939-ws74xprt.txt item: #981 of 2876 id: cord-268952-3j43p9j3 author: Ueda Oshima, Masumi title: Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach date: 2020-09-26 words: 3646 flesch: 34 summary: Finally, as the Seattle Children's Hospital had a significantly lower caseload of COVID-19 patients compared to the adult medicine services at UW, any willing adolescent and young adult patient in need of urgent transplantation was transferred to receive care by our pediatric BMT colleagues. Situated in the initial epicenter of the pandemic, the Blood and Marrow Transplant (BMT) Program at Fred Hutchinson Cancer Research Center (Fred Hutch)/Seattle Cancer Care Alliance (SCCA) was at the forefront of delivering care to transplant patients during the surge of this public health crisis. keywords: care; cell; clinical; covid-19; pandemic; patients; program; staff; transplant; transplantation cache: cord-268952-3j43p9j3.txt plain text: cord-268952-3j43p9j3.txt item: #982 of 2876 id: cord-268974-7bqh1yas author: Capitelli-McMahon, Helen title: Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic date: 2020-11-02 words: 482 flesch: 38 summary: Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic The Untold Toll -The Pandemic's Effects on Patients without Covid-19 Global incidence of incomplete surgical excision in adult patients with non-melanoma skin cancer: study protocol for a systematic review and meta-analysis of observational studies Margins in skin excision biopsies: principles and guidelines Despite prioritisation of oncological services throughout the pandemic thus far, our findings show substantial differences in the patients accessing skin oncology services in our centre. keywords: excision; patients cache: cord-268974-7bqh1yas.txt plain text: cord-268974-7bqh1yas.txt item: #983 of 2876 id: cord-269009-0i2bvt77 author: D’Souza, Rohan title: A critical review of the pathophysiology of thrombotic complications and clinical practice recommendations for thromboprophylaxis in pregnant patients with COVID‐19 date: 2020-08-05 words: 3302 flesch: 28 summary: The origin of the very elevated D-dimer levels in COVID-19 patients may at least in part be the pneumocytes, which can produce urokinase. COVID-19 patients have a higher thromboembolic risk, which is further increased by the pregnancy and postpartum situation. keywords: coagulation; covid-19; patients; pregnancy; pulmonary; risk; thromboprophylaxis; vte; women cache: cord-269009-0i2bvt77.txt plain text: cord-269009-0i2bvt77.txt item: #984 of 2876 id: cord-269031-sz8ieltb author: Solé, G title: Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date: 2020-04-20 words: 5750 flesch: 33 summary: key: cord-269031-sz8ieltb authors: Solé, G; Salort-Campana, E; Pereon, Y; Stojkovic, T; Wahbi, K; Cintas, P; Adams, D; Laforet, P; Tiffreau, V; Desguerre, I; Pisella, LI; Molon, A; Attarian, S title: Guidance for the care of neuromuscular patients during the COVID-19 pandemic outbreak from the French Rare Health Care for Neuromuscular Diseases Network date: 2020-04-20 journal: Rev Neurol (Paris) DOI: 10.1016/j.neurol.2020.04.004 sha: doc_id: 269031 cord_uid: sz8ieltb Abstract In France, the epidemic phase of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in February 2020 and resulted in the implementation of emergency measures and a degradation in the organization of neuromuscular reference centers. The French Rare Health Care for Neuromuscular Diseases Network (FILNEMUS) also announced guidance in an attempt to homogenize the management of neuromuscular patients in this context to limit the contamination of extremely fragile patients while avoiding the loss of survival chance linked to the interruption of essential treatment or follow-up. keywords: care; context; covid-19; diseases; emergency; gravis; health; months; myasthenia; patients; risk; therapy; treatment cache: cord-269031-sz8ieltb.txt plain text: cord-269031-sz8ieltb.txt item: #985 of 2876 id: cord-269051-nl0jfqxt author: Patel, Krish title: Use of the IL‐6R Antagonist Tocilizumab in Hospitalized COVID‐19 Patients date: 2020-08-03 words: 1923 flesch: 50 summary: Among ICU patients in the United States (US), centers have reported 50% mortality.(5,6) Tocilizumab, an IL‐6 receptor (IL‐6R) antagonist, is FDA approved for the management of CAR T‐cell related Cytokine Release Syndrome (CRS) and may have utility in treatment of some COVID‐19 patients. Among ICU patients in the United States (US), centers have reported 50% mortality. keywords: data; day; patients; table; tocilizumab cache: cord-269051-nl0jfqxt.txt plain text: cord-269051-nl0jfqxt.txt item: #986 of 2876 id: cord-269087-f9hyntvf author: Li, X. title: A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19 date: 2020-04-04 words: 4282 flesch: 45 summary: Yet, in more general, infectious diseases often tend to behave less aggressively in child patients. A single child patient passed away; for other child patients, progression of the disease was observed as mild [9, 10] . keywords: cases; children; coronavirus; cov-2; covid-19; diagnosis; infection; patients; sars cache: cord-269087-f9hyntvf.txt plain text: cord-269087-f9hyntvf.txt item: #987 of 2876 id: cord-269099-q5nyzlhs author: Lee, Jisun title: Exploring the spatial arrangement of patient rooms for minimum nurse travel in hospital nursing units in Korea date: 2020-07-23 words: 7536 flesch: 49 summary: This study examined the effects of spatial features on nurse walking distance (NWD), particularly focusing on the arrangement of patient rooms. Among Korean inpatient unit case studies, Shin and Kang (2016) assessed nurse walking distances using traditional point-to-point linear measurement based on field interviews of nurses' patient room assignments. keywords: bed; distance; et al; nurse; patient; rooms; station; study; travel; units; walking cache: cord-269099-q5nyzlhs.txt plain text: cord-269099-q5nyzlhs.txt item: #988 of 2876 id: cord-269105-yuphgyrn author: Dumantepe, Mert title: Subsegmental Thrombus in COVID-19 Pneumonia: Immunothrombosis or Pulmonary Embolism? Data Analysis of Hospitalised Patients With Coronavirus Disease date: 2020-08-24 words: 1328 flesch: 32 summary: A novel coronavirus from patients with pneumonia in China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Incidence of venous thromboembolism in hospitalized patients with COVID-19 Clinical management of severe acute respiratory infection (SARI) when novel coronavirus (2019-nCoV) infection is suspected (Interim guidance Version 1.2) Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past SARS-CoV-2 and viral sepsis: observations and hypotheses The stimulation of thrombosis by hypoxia Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography Catheter directed ultrasound-accelerated thrombolysis for the treatment of acute pulmonary embolism Improvements in pulmonary artery pressure and right ventricular function after ultrasound-accelerated catheter-directed thrombolysis for the treatment of pulmonary embolism Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. The current results showed frequent VTE in patients with COVID-19 infection. keywords: coronavirus; covid-19; patients; pulmonary cache: cord-269105-yuphgyrn.txt plain text: cord-269105-yuphgyrn.txt item: #989 of 2876 id: cord-269190-w74bjtq1 author: Lennox, Angela M. title: Care of the Geriatric Rabbit date: 2010-02-11 words: 3435 flesch: 39 summary: Although estimation of GFR is unavailable for rabbit patients, serious consideration should be given to lowering dosages of all drugs, in particular, any drugs metabolized by glomerular filtration in rabbits with suspected renal insufficiency. The author and others frequently see geriatric rabbits that have had years of regular dental care. keywords: anesthesia; author; care; disease; failure; owners; patients; pet; rabbits; use cache: cord-269190-w74bjtq1.txt plain text: cord-269190-w74bjtq1.txt item: #990 of 2876 id: cord-269205-g6eyvnou author: Nilsen, Marci Lee title: Prevision of multidisciplinary head and neck cancer survivorship care during the 2019 novel coronavirus pandemic date: 2020-05-18 words: 3832 flesch: 42 summary: Despite the challenges of remote patient care, utilizing phone communication allows for continued nutrition intervention during this time as well as continuity of care. The population of patients who have the greatest need for immediate care includes patients currently undergoing radiation therapy with or without chemotherapy and immunotherapy-approximately 30% to 40% of HNC patients undergoing radiation treatment experience a toxicity-related hospitalization. keywords: cancer; care; head; hnc; neck; pandemic; patients; therapy; treatment cache: cord-269205-g6eyvnou.txt plain text: cord-269205-g6eyvnou.txt item: #991 of 2876 id: cord-269275-b7xxk48t author: Tang, Xiaojia title: Neurological manifestations in COVID-19 and its possible mechanism date: 2020-09-27 words: 4640 flesch: 39 summary: Four formal reports have described neurological problems in SARS patients, including polyneuropathy The symptoms of hypoxia in COVID-19 patients are very obvious, and critical patients need ventilator support. keywords: acute; cells; coronavirus; cov-2; covid-19; human; infection; novel; patients; rhabdomyolysis; sars; syndrome; system cache: cord-269275-b7xxk48t.txt plain text: cord-269275-b7xxk48t.txt item: #992 of 2876 id: cord-269280-1zbxjmxu author: Shao, Connie title: The COVID trolley dilemma date: 2020-05-14 words: 2902 flesch: 54 summary: At a time when hospitals are furloughing staff, reducing salaries for staff, and scrambling for PPE for their employees, it would be in the financial interest of keeping a hospital running to proceed with elective surgeries in an effort to help mend the expected deficits of hundreds of millions per hospital. As certain areas in the country have the resources to resume elective surgery, how will they be remembered in a time when other, heavily affected parts of the country struggle with unmet needs for goods and services? keywords: covid-19; elective; hospital; number; pandemic; patients; trolley cache: cord-269280-1zbxjmxu.txt plain text: cord-269280-1zbxjmxu.txt item: #993 of 2876 id: cord-269289-6uog10j4 author: Mabillard, Holly title: Electrolyte Disturbances in SARS-CoV-2 Infection date: 2020-07-22 words: 5686 flesch: 37 summary: Common symptoms include fever (43% of patients), cough (50%) and dyspnoea (29%) but other features such as myalgia (36%), diarrhoea (19%), anosmia and hypogeusia (10%) are also common 1 . The most frequent serious manifestation of infection is pneumonia with 15% of patients developing serious manifestations such as hypoxia, dyspnoea, extensive pulmonary involvement and acute respiratory distress syndrome (ARDS) 2-5 . keywords: cov-2; disease; hypokalaemia; infection; patients; potassium; renal; sars; sodium cache: cord-269289-6uog10j4.txt plain text: cord-269289-6uog10j4.txt item: #994 of 2876 id: cord-269345-5tlyy8jp author: Minuz, Pietro title: High rate of pulmonary thromboembolism in patients with SARS-CoV-2 pneumonia date: 2020-06-18 words: 693 flesch: 41 summary: 84 Considering that an undiagnosed thromboembolic process might worsen patients´ outcome, we 86 would suggest including a CTPA scan in the diagnostic assessment of patients with Sars-CoV-2 87 pneumonia, high D-dimer, and refractory or rapidly deteriorating hypoxemic respiratory failure. Although the prevalence in our small cohort of 72 non-ICU patients is less than the one recently reported in ICU patients [1] , it seems to confirm the 73 increased risk of PTE in COVID-19 patients. keywords: patients; pneumonia cache: cord-269345-5tlyy8jp.txt plain text: cord-269345-5tlyy8jp.txt item: #995 of 2876 id: cord-269425-e9iyso7n author: Bhattacharjee, Sukrita title: Immune Thrombocytopenia Secondary to COVID-19: a Systematic Review date: 2020-09-19 words: 5429 flesch: 43 summary: A systematic review was done to analyze the clinical profile and outcomes in a total of 45 cases of new-onset ITP in COVID-19 patients described in literature until date. Clinicians should also take note of several reports of ITP in COVID-19 patients in post-recovery period (21%). keywords: bleeding; cases; covid-19; immune; itp; onset; patients; platelet; response; review; thrombocytopenia cache: cord-269425-e9iyso7n.txt plain text: cord-269425-e9iyso7n.txt item: #996 of 2876 id: cord-269469-7pmnxi9a author: Bikdeli, Behnood title: Anticoagulation in COVID-19: Randomized trials should set the balance between excitement and evidence date: 2020-10-08 words: 1060 flesch: 35 summary: A Single Health System Study D-dimer cut-off points and risk of venous thromboembolism in adult hospitalized patients with COVID-19 Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19 Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease Intermediate versus Standard-dose Prophylactic anticoagulation and Statin Therapy versus Placebo in Critically-ill Patients with COVID-19: Rationale and Design of the INSPIRATION/ INSPIRATION-S Studies Anticoagulant interventions in hospitalized patients with COVID-19: COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis High Prevalence of Deep Vein Thrombosis in Mechanically Ventilated COVID-19 Patients High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19 Anticoagulation, Mortality, Bleeding and Pathology Among Patients Hospitalized with COVID-19: keywords: covid-19; patients; study cache: cord-269469-7pmnxi9a.txt plain text: cord-269469-7pmnxi9a.txt item: #997 of 2876 id: cord-269503-ij4u980v author: Amaratunga, Eluwana A title: Bradycardia in Patients With COVID-19: A Calm Before the Storm? date: 2020-06-13 words: 3497 flesch: 41 summary: As previously described, acute myocardial injury was thought to be the most common cardiac manifestation in COVID-19 patients and potential for developing cardiac arrhythmias has been noted in a few studies. The etiology of cardiac manifestations in COVID-19 patients seems to be multifactorial, which includes direct viral myocardial damage, hypoxia, hypotension, enhanced inflammatory status, angiotensin-converting enzyme 2 (ACE2)-receptor downregulation, drug toxicity, and endogenous catecholamine adrenergic status [5, 7] . keywords: admission; bradycardia; covid-19; day; days; onset; patients cache: cord-269503-ij4u980v.txt plain text: cord-269503-ij4u980v.txt item: #998 of 2876 id: cord-269511-bfd1dmt3 author: Salacup, Grace title: Characteristics and Clinical Outcomes of COVID‐19 Patients in an Underserved‐Inner City Population: A Single Tertiary Center Cohort date: 2020-07-03 words: 3455 flesch: 46 summary: 11 Older age was established as risk factor for inpatient death in COVID-19 patients. 19, 20 However, another non-randomized study showed treatment with methylprednisolone decreased the risk of death among COVID-19 patients with ARDS. keywords: covid-19; death; inpatient; mortality; outcomes; patients; study cache: cord-269511-bfd1dmt3.txt plain text: cord-269511-bfd1dmt3.txt item: #999 of 2876 id: cord-269554-fzu6dy4e author: Hussein, M. H. title: Asthma in COVID-19: An extra chain fitting around the neck? date: 2020-07-15 words: 3093 flesch: 45 summary: Univariate analysis revealed that asthma patients were more likely to be obese (75% vs 54.2%, p=0.001), with higher frequency of intubation (40.3% vs 27.8%, p = 0.036), and required longer duration of hospitalization (15.1{+/-}12.5 vs 11.5{+/-}10.6, p=0.015). We sought to analyze the effect of asthma on the disease progression and outcomes of COVID-19 patients. keywords: asthma; asthmatic; covid-19; license; medrxiv; outcomes; patients; preprint cache: cord-269554-fzu6dy4e.txt plain text: cord-269554-fzu6dy4e.txt item: #1000 of 2876 id: cord-269564-r5mmsnbx author: Hans, Diana title: Rapidly Fatal Infections date: 2008-05-31 words: 7557 flesch: 44 summary: During the 2003 to 2004 influenza season, the CDC received reports of severe pneumonia caused by S aureus and MRSA among previously healthy children and adults after influenza virus infection [75] . In addition, a dramatic increase in the median age of patients with bacterial meningitis has been observed. keywords: aureus; cases; disease; encephalitis; group; infections; influenza; meningitis; mrsa; patients; pneumonia; streptococcus; syndrome; treatment; tss cache: cord-269564-r5mmsnbx.txt plain text: cord-269564-r5mmsnbx.txt item: #1001 of 2876 id: cord-269591-lu415jcp author: None title: Recommendations Regarding COVID19 Infection in Rheumatic Patients in Greece date: 2020-03-31 words: 838 flesch: 26 summary: Mediterr J Rheumatol DOI: 10.31138/mjr.31.1.6 sha: doc_id: 269591 cord_uid: lu415jcp nan The Greek Rheumatology Society & Professional Association of Rheumatologists (ERE-EPERE) in response to the recent COVID19 pandemic has issued the following recommendations regarding COVID19 infection in patients with rheumatic diseases. munosuppressive/ immunomodulatory therapies (with the exception of GCs and hydroxychloroquine) in patients with rheumatic diseases who: -had high risk contact (duration> 15 min, distance <2 m) with a patient with confirmed COVID19 infection, or -have symptoms of acute respiratory infection or -develop COVID19 infection The above recommendations may be revised based on the emerging new data and the new guidelines issued by our National Organization of Public Health. keywords: infection; patients cache: cord-269591-lu415jcp.txt plain text: cord-269591-lu415jcp.txt item: #1002 of 2876 id: cord-269690-6r2bfydw author: De Lorenzo, Rebecca title: Residual clinical damage after COVID-19: A retrospective and prospective observational cohort study date: 2020-10-14 words: 4423 flesch: 40 summary: This is consistent with the hypothesis that SARS-CoV-2 infection may be associated with chronic cardiovascular damage [30] , and highlights the need of cardiovascular care in the management of COVID-19 patients. Among hospitalised patients, age ≥63 years, or age <63 plus non-invasive ventilation or diabetes identified those with the highest probability to need follow-up. keywords: age; analysis; covid-19; disease; follow; malnutrition; need; patients; ptsd cache: cord-269690-6r2bfydw.txt plain text: cord-269690-6r2bfydw.txt item: #1003 of 2876 id: cord-269776-hj1s3ipp author: Agostoni, Angelo title: Hereditary and acquired angioedema: Problems and progress: Proceedings of the third C1 esterase inhibitor deficiency workshop and beyond date: 2004-09-11 words: 50588 flesch: 41 summary: The plasma kallikrein-kinin system counterbalances the renin-angiotensin system The physiologic basis of assembly and activation of the plasma kallikrein/kinin system Mechanism of enhanced kinin release from high molecular weight kininogen by plasma kallikrein after its exposure to plasmin Detection of active kallikrein in induced blister fluids of hereditary angioedema patients Dose-dependent effects of postmenopausal estrogen and progestin on antithrombin III and factor XII Increased euglobulin fibrinolytic potential in women on oral contraceptives low in oestrogen-levels of extrinsic and intrinsic plasminogen activators, prekallikrein, factor XII, and C1-inactivator Molecular basis of estrogen regulation of Hageman factor XII gene expression Contact factors in plasma from women on oral contraception-significance of factor XI for the measured activity of factor XII Biochemical and molecular pharmacology of kinin receptors Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation Receptors for kinins: from classical pharmacology to molecular biology Mechanisms regulating the expression, self-maintenance, and signaling-function of the bradykinin B2 and B1 receptors Regulation of bradykinin B2-receptor expression by oestrogen Coexistence of hereditary angioedema and Turner's syndrome Hereditary angioedema precipitated by estrogen replacement therapy in a menopausal woman Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by oral contraceptives or hormone replacement therapy Recurrent angioedema: familial and oestrogen-induced Angioedema and oral contraception Recurrent angioedema associated with hypogonadism or anti-androgen therapy Estrogen induction and contact phase activation of human factor XII Enhanced expression of factor XII (Hageman factor) in isolated livers of estrogenand prolactin-treated rats The influence of estrogen and prolactin on Hageman factor (factor XII) titer in ovariectomized and hypophysectomized rats Differential regulation of kininogen gene expression by estrogen and progesterone in vivo The effect of oestrogen dose and progestogen type on haemostatic changes in women taking low dose oral contraceptives Effects of a very low-estrogen oral contraceptive on clotting factors, carbohydrate metabolism and plasma lipids and lipoproteins Contact activation factors in plasma from women using oral contraceptives-increased levels of factor XII, kinin-free high molecular weight kininogen and acetone-activated kallikrein Estrogen-associated thromboembolism Contact factor mediated fibrinolysis is increased by the combined oral contraceptive pill Prospective randomized study of effects of unopposed estrogen replacement therapy on markers of coagulation and inflammation in postmenopausal women Positive impact of hormone replacement therapy on the fibrinolytic system: a long-term randomized controlled study in healthy postmenopausal women Postmenopausal hormone replacement therapy increases coagulation activity and fibrinolysis Effect of long-term hormone replacement therapy on angiotensin-converting enzyme activity and bradykinin in postmenopausal women with essential hypertension and normotensive postmenopausal women Estrogen regulation of angiotensin-converting enzyme mRNA Sex hormones in hereditary angioneurotic oedema The complete drug reference Bethesda: American Society of Health-System Pharmacists DRUGDEXÒ system Hereditary angioedema and oral contraception Effects of methylamine and heparin on a rapid chromogenic assay of C1-esterase inhibitor in plasma Effect of time, temperature and additives on a functional assay of C1 inhibitor Effects of estrogen replacement therapy on the renin-angiotensin system in postmenopausal women Management and diagnostic guidelines for urticaria and angio-oedema Hereditary angioneurotic oedema in three families: symptomatic heterogeneity, complement analysis and therapeutic trials Hereditary angioneurotic oedema in Finland: clinical, immunological and genealogical studies Hereditary angioedema due to deficit of C1 esterase inhibitor Hereditary angioneurotic edema: a clinical survey C1-INH defect as an example of deficiency disease Hereditary angioedema: danazol therapy in a 5-year-old child Hereditary angioneurotic oedema: current management in pregnancy A multicentre evaluation of the diagnostic efficiency of serological investigations for C1 inhibitor deficiency Inherited and acquired deficiencies of C1 esterase inhibitor in humans C3 is activated in hereditary angioedema, and C1/C1-inhibitor complexes rise during physical stress in untreated patients Contact system in healthy term newborns: reference values in cord blood Application of a monoclonal antibody against a neoepitope on activated C4 in an ELISA for the quantification of complement activation via the classical pathway C1 inhibitor and diagnosis of hereditary angioedema in newborns Complement components in 100 newborns and their mothers determined by electroimmunoassay Angioedema: a review on the acquired, allergic or non-allergic, and the hereditary forms Serum complement levels in infancy: age related changes Influence of age and sex on serum complement components in children Development of the human coagulation system in the full-term infant Plasma protease inhibitors in premature infants: influence of gestational age, postnatal age, and health status Serum complement profiles in infants and children Misdiagnosis of hereditary angio-oedema type 1 and type 2 Acute consumption of C1 inhibitor in a patient with acquired C1-inhibitor deficiency syndrome Normal complement C4 values do not exclude hereditary angioedema Hereditary angioneurotic oedema Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate Replacement therapy in hereditary angioedema: successful treatment of acute episodes of angioedema with partly purified C1 inhibitor C1 INH concentrate in the therapy of hereditary angioedema C1-esterase inhibitor transfusions in patients with hereditary angioedema Replacement therapy in hereditary angioedema: successful treatment of two patients with fresh frozen plasma C1-inhibitor deficiency and angioedema Treatment of hereditary angioedema Letter: anaphylactic reaction to aprotinin DX-88 and HAE: a developmental perspective The synthetic Kunitz domain protein DX-88 to treat angioedema in patients with hereditary angioedema Role of kinins in seasonal allergic rhinitis: icatibant, a bradykinin B2 receptor antagonist, abolishes the hyperresponsiveness and nasal eosinophilia induced by antigen Efficacy and tolerability of Icatibant (Hoe 140) in patients with moderately severe chronic bronchial asthma Jerini announces positive phase II study results with Icatibant for the treatment of Hereditary Angioedema A phase I study of recombinant human C1-INH in asymptomatic patients with hereditary angioedema-HAE Pharming features clinical results of C1 inhibitor at investigator meeting [press release Treatment of hereditary angioedema with danazol: reversal of clinical and biochemical abnormalities Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives Side effects of long-term prophylaxis with attenuated androgens in hereditary angioedema: comparison of treated and untreated patients The long-term safety of danazol in women with hereditary angioedema Long-term treatment of hereditary angioedema with attenuated androgens: a survey of a 13-year experience Danazol therapy: an unusual aetiology of hepatocellular carcinoma Hepatocellular adenomas in patients taking danazol for hereditary angio-oedema Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema A case of hereditary angioneurotic oedema, successfully treated with epsilonaminocaproic acid: studies on C'1 esterase inhibitor, C'1 activation, plasminogen level and histamine metabolism Long-term prophylaxis with C1-inhibitor (C1 INH) concentrate in patients with recurrent angioedema caused by hereditary and acquired C1-inhibitor deficiency Pharmacokinetic parameters of C1-inhibitor concentrate in 40 patients with hereditary angio-oedema (HAE)-a prospective study Acute airway obstruction following tooth extraction in hereditary angioedema Oral manifestations and dental management of patients with hereditary angioedema Hereditary angioedema: report of case Prophylactic use of epsilon aminocaproic acid for oral surgery in a patient with hereditary angioneurotic edema Tranexamic acid: preoperative prophylactic therapy for patients with hereditary angioneurotic edema Intravenous tranexamic acid in the management of hereditary angio-oedema Potentially fatal hereditary angioedema: a review and case report The efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial and dental procedures Successful off-pump coronary artery bypass graft surgery in a patient with hereditary angioedema Preoperative prophylaxis for C1 esterase-inhibitor deficiency in patients undergoing oral surgery: a report of three cases Hereditary angioedema: uncomplicated maxillofacial surgery using short-term C1 inhibitor replacement therapy C1-esterase inhibitor concentrate prevents upper airway obstruction in hereditary angio-oedema Acquired angioedema as the presenting feature of lymphoproliferative disorders of mature B-lymphocytes Spontaneous regression of acquired C1 esterase inhibitor deficiency associated with splenic marginal zone lymphoma presenting with recurrent angio-oedema Acquired angioedema associated with rectal carcinoma and its response to danazol therapy: acquired angioedema treated with danazol Activation of the contact system and fibrinolysis in autoimmune acquired angioedema: a rationale for prophylactic use of tranexamic acid Angioneurotic edema with acquired C1-inhibitor deficiency and autoantibody to C1-inhibitor: response to plasmapheresis and cytotoxic therapy Purity, activity, and virus safety of a pasteurized antithrombin concentrate A factor VIII concentrate, highly purified and heated in solution Virus-safe plasma proteins: elimination of viruses of risk by the manufacturing procedure Inactivation of hepatitis A virus by pasteurization and elimination of picornaviruses during manufacture of factor VIII concentrate Absence of anti-human immunodeficiency virus types 1 and 2 seroconversion after the treatment of hemophilia A or von Willebrand's disease with pasteurized factor VIII concentrate Absence of hepatitis after treatment with a pasteurized factor VIII concentrate in patients with hemophilia and no previous transfusions Effectiveness of alternative treatments for reducing potential viral contaminants from plasma-derived products Inactivation of parvovirus B19 during pasteurization of human serum albumin A novel coronavirus associated with severe acute respiratory syndrome Virus safety of pasteurized clotting factor concentrates: an eleven year follow up Hepatitis C and pasteurized C1-inhibitor concentrate Prospective virus safety follow-up after therapy with a pasteurized C1-inhibitor concentrate Prophylactic treatment with pasteurised C1 inhibitor in herditary angioedema (HAE)-a prospective 32 months follow up Prospective follow up of clinical manifestation and therapy in children with hereditary angioedema (HAE) High-titer screening PCR: a successful strategy for reducing the parvovirus B19 load in plasma pools for fractionation Prospective audit of adverse reactions occurring in 459 primary antibody-deficient patients receiving intravenous immunoglobulin State of care for hemophilia in pediatric patients Hereditary angioedema Treatment of acute attacks of hereditary angioedema with C1-inhibitor concentrate Clinical studies of sudden upper airway obstruction in patients with hereditary angioedema due to C1 esterase inhibitor deficiency Proteolytic inactivation of plasma C1-inhibitor in sepsis Expression of active human C1 inhibitor serpin domain in Escherichia coli N-and O-glycans of recombinant human C1 Inhibitor expressed in the milk of transgenic rabbits Production of complex human glycoproteins in yeast Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor Recombinant C1 inhibitor P5/P3 variants display resistance to catalytic inactivation by stimulated neutrophils The effect of danazol in the treatment of chronic cystic mastitis Danazol-induced pseudomenopause in the management of endometriosis Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women Cortical and trabecular bone mineral content in women with endometriosis: effect of gonadotropin-releasing hormone agonist and danazol A comparison of the skeletal effects of goserelin and danazol in premenopausal women with endometriosis Evidence of similar increases in bone turnover during nafarelin and danazol use in women with endometriosis Amino acids mutated in HAE patients are depicted in yellow ball-and-stick. keywords: aae; ace; activation; activity; acute; angioedema; angioedema attacks; attacks; bradykinin; c1 esterase; c1 inhibitor; c1nh; case; complement; concentrations; danazol; data; diagnosis; disease; effects; estrogen; factor; functional; gene; hae; hae attacks; hae patients; hae type; hereditary; human c1; inh; inh concentrate; inh concentrations; inh deficiency; inh function; inhibitor deficiency; kallikrein; life; mutations; normal; patients; plasma; plasma c1; prophylaxis; protein; results; studies; study; symptoms; system; term; therapy; treatment; type; use; women; xii cache: cord-269776-hj1s3ipp.txt plain text: cord-269776-hj1s3ipp.txt item: #1004 of 2876 id: cord-269835-mz7i66qp author: Furfaro, Federica title: SFED recommendations for IBD endoscopy during COVID-19 pandemic: Italian and French experience date: 2020-06-11 words: 7284 flesch: 30 summary: ESGE and ESGENA Position Statement on Gastrointestinal Endoscopy and the COVID-19 Pandemic Implications of COVID-19 for patients with pre-existing digestive diseases Practice of endoscopy during COVID-19 pandemic: position statements of the Asian Pacific Society for Digestive Endoscopy (APSDE-COVID statements) COVID-19 and gastrointestinal endoscopies: current insights and emergent strategies Endoscopy in inflammatory bowel diseases during the COVID-19 pandemic and postpandemic period Coronavirus COVID-19 Global Cases Report of the WHO-China Joint Mission on Coronavirus Disease Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study Sensitivity of nasopharyngeal, nasal and throat swab for the detection of SARS-CoV-2 Respiratory virus shedding in exhaled breath and efficacy of face masks Société Française d'Endoscopie Digestive. Nat Rev Gastroenterol Hepatol DOI: 10.1038/s41575-020-0319-3 sha: doc_id: 269835 cord_uid: mz7i66qp The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has required a complete change in the management of patients with inflammatory bowel disease (IBD) who need to undergo endoscopic procedures. keywords: bowel; colitis; cov-2; covid-19; crohn; disease; endoscopy; faecal; ibd; infection; pandemic; patients; risk; sars; symptoms cache: cord-269835-mz7i66qp.txt plain text: cord-269835-mz7i66qp.txt item: #1005 of 2876 id: cord-269981-xm0by310 author: Shen, Cheng title: Perioperative preparation in thoracic day surgery: Battle against COVID‐19 date: 2020-06-17 words: 1664 flesch: 44 summary: Patients have to visit appropriate specialist clinics to evaluate whether they qualify for thoracic day surgery. Patients should also meet the standard requirements for thoracic day surgery, including patient age (≤55 years), diameter of the pulmonary nodule on thoracic CT scan (≤3 cm) for early stage lung cancer or benign pulmonary nodule patient, and an ASA status of 1 or 2. keywords: covid-19; day; infection; patients; surgery; thoracic cache: cord-269981-xm0by310.txt plain text: cord-269981-xm0by310.txt item: #1006 of 2876 id: cord-270019-er70ehk4 author: Yang, Kunyu title: Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study date: 2020-05-29 words: 4271 flesch: 44 summary: First case of 2019 novel coronavirus in the United States Transmission of 2019-nCoV infection from an asymptomatic contact in Germany COVID-19) pandemic Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Epidemic situation of COVID-19 (in Chinese) There should be no ESKAPE for febrile neutropenic cancer patients: the dearth of effective antibacterial drugs threatens anticancer efficacy Diagnostic strategy for hematology and oncology patients with acute respiratory failure: randomized controlled trial Infectious complications in patients with chronic lymphocytic leukemia: pathogenesis, spectrum of infection, and approaches to prophylaxis Acute respiratory distress syndrome in patients with malignancies Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance Clinical characteristics of coronavirus disease 2019 in China International Severe Acute Respiratory and emerging Infection Consortium. Patients with haematological malignancies were younger than those with solid tumours ( of 177 patients) were more frequently seen in patients with haematological malig nancies than in those with solid tumours. keywords: cancer; clinical; covid-19; data; hospital; onset; patients; risk; study; weeks cache: cord-270019-er70ehk4.txt plain text: cord-270019-er70ehk4.txt item: #1007 of 2876 id: cord-270079-vwnzp6zj author: Galanis, Nikiforos title: Coagulopathy in COVID-19 infection: a case of acute upper limb ischemia date: 2020-07-02 words: 1266 flesch: 35 summary: He was admitted to G. Papanikolaou General Hospital in Thessaloniki, a tertiary hospital set as a reference center for COVID-19 patients. key: cord-270079-vwnzp6zj authors: Galanis, Nikiforos; Stavraka, Chara; Agathangelidis, Filon; Petsatodis, Evangelos; Giankoulof, Christos; Givissis, Panagiotis title: Coagulopathy in COVID-19 infection: a case of acute upper limb ischemia date: 2020-07-02 journal: J Surg Case Rep DOI: 10.1093/jscr/rjaa204 sha: doc_id: 270079 cord_uid: vwnzp6zj Coagulation abnormalities and thrombosis have been recently identified as sequelae of severe infection with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). keywords: coagulopathy; covid-19; infection; patients cache: cord-270079-vwnzp6zj.txt plain text: cord-270079-vwnzp6zj.txt item: #1008 of 2876 id: cord-270124-tqhkzd2w author: Campos, Fábio Guilherme title: General recommendations to the colorectal surgeon during the COVID-19 pandemic date: 2020-06-19 words: 2198 flesch: 39 summary: ACS COVID-19 and Surgery The Royal College of Surgeons Updated Intercollegiate General Surgery Guidance on COVID-19 Coronavirus pandemic and colorectal surgery: practical advice based on the Italian experience Digestive Symptoms in COVID-19 Patients With Mild Disease Severity: In suspected patients, utmost care should be taken when handling stool in the rectal ampoule. keywords: covid-19; infection; pandemic; patients; procedures; recommendations; surgery cache: cord-270124-tqhkzd2w.txt plain text: cord-270124-tqhkzd2w.txt item: #1009 of 2876 id: cord-270153-krhkqcev author: Khosla, Seema title: Implementation of Synchronous Telemedicine into Clinical Practice date: 2020-08-04 words: 5448 flesch: 60 summary: If the practice is currently overwhelmed with patients, then realistically there is no room for telemedicine patients. The scheduling staff will need to schedule telemedicine visits, unless a platform that will automate this process is used. keywords: care; clinicians; health; patient; practice; sleep; technology; telemedicine; visit cache: cord-270153-krhkqcev.txt plain text: cord-270153-krhkqcev.txt item: #1010 of 2876 id: cord-270210-gfy2ytg5 author: Drent, Marjolein title: Benefit of Wearing an Activity Tracker in Sarcoidosis date: 2020-08-22 words: 4453 flesch: 47 summary: The Burden of Sarcoidosis Symptoms from a Patient Perspective Nonorgan manifestations of sarcoidosis Exercise capacity, muscle strength and fatigue in sarcoidosis Daily life physical activity in patients with chronic stage IV sarcoidosis: A multicenter cohort study Sarcoidosis-associated fatigue Fatigue and health-related quality of life in patients with pulmonary sarcoidosis treated by oral Corticosteroids Everyday cognitive failure and depressive symptoms predict fatigue in sarcoidosis: A prospective follow-up study Sarcoidosis and work participation: The need to develop a disease-specific core set for assessment of work ability Fatigue in sarcoidosis and exercise tolerance, dyspnea, and quality of life Gender differences in sarcoidosis: Symptoms, quality of life, and medical consumption Does physical training reduce fatigue in sarcoidosis? Benefits of physical training in patients with idiopathic or end-stage sarcoidosis-related pulmonary fibrosis: A pilot study Benefits of Physical Training in Sarcoidosis Short-Term Effects of a Multimodal 3-Week Inpatient Pulmonary Rehabilitation Programme for Patients with Sarcoidosis: The ProKaSaRe Study A systematic review of randomized controlled trials on the effectiveness of computer-tailored physical activity and dietary behavior promotion programs: An update Maximizing the healthcare environment: A systematic review exploring the potential of computer technology to promote self-management of chronic illness in healthcare settings Using electronic/computer interventions to promote physical activity The HealtheSteps lifestyle prescription program to improve physical activity and modifiable risk factors for chronic disease: A pragmatic randomized controlled trial Systematic review of the validity and reliability of consumer-wearable activity trackers Effect of 'activity monitor-based' counseling on physical activity and health-related outcomes in patients with chronic diseases: A systematic review and meta-analysis Counting Steps: A New Way to Monitor Patients with Pulmonary Arterial Hypertension Experience with activity monitors of patients with COPD, sarcoidosis and pulmonary fibrosis in the Netherlands the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee ATS statement: Guidelines for the six-minute walk test Reference values for a multiple repetition 6-minute walk test in healthy adults older than 20 years Reliability and Validity of Ten Consumer Activity Trackers Depend on Walking Speed Fitbit Charge HR Wireless Heart Rate Monitor: Validation Study Conducted Under Free-Living Conditions Fatigue is associated with quality of life in sarcoidosis patients Psychometric qualities of the Fatigue Assessment Scale in Croatian sarcoidosis patients Physical activity and training in sarcoidosis: Review and experience-based recommendations Feasibility of a Comprehensive Home Monitoring Program for Sarcoidosis It's LiFe! The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. keywords: activity; coaching; exercise; fatigue; group; patients; sarcoidosis; study cache: cord-270210-gfy2ytg5.txt plain text: cord-270210-gfy2ytg5.txt item: #1011 of 2876 id: cord-270245-zziwb2jy author: Russell, Beth title: Factors Affecting COVID-19 Outcomes in Cancer Patients: A First Report From Guy's Cancer Center in London date: 2020-07-22 words: 4115 flesch: 42 summary: In this analysis of our data, we had three aims: 1) To describe demographic and clinical characteristics of COVID-19 positive cancer patients, in terms of their COVID-19 and cancer diagnoses. There was a non-statistically significant indication that those patients who were diagnosed with cancer more than 24 months ago were at a higher risk of presenting with severe COVID-19 as compared to those diagnosed during the last 24 months Using multivariate modeling based on a directed acyclic graph, this study reports on a large cohort of COVID-19 positive cancer patients from a single institution. keywords: cancer; clinical; cohort; covid-19; death; patients; severity; study; treatment cache: cord-270245-zziwb2jy.txt plain text: cord-270245-zziwb2jy.txt item: #1012 of 2876 id: cord-270294-g95skuik author: Johnstone, Jennie title: Viral Infection in Adults Hospitalized With Community-Acquired Pneumonia Prevalence, Pathogens, and Presentation date: 2008-12-31 words: 4442 flesch: 33 summary: In our study, patients with pneumonia and respiratory viral infection were older and more frail than 1146 those without evidence of viral infection. Given the 15% prevalence of viral infection in adults in our study, and the indistinguishable presentation from typical bacterial pneumonia, our results suggest routine isolation (with droplet and contact precautions) of all adults with pneumonia, from the time of hospital admission until respiratory viral infection is ruled out, should be considered to help prevent the nosocomial transmission of respiratory viruses. keywords: adults; hmpv; infection; influenza; pathogens; patients; pneumonia; study; viruses cache: cord-270294-g95skuik.txt plain text: cord-270294-g95skuik.txt item: #1013 of 2876 id: cord-270327-v4td3zsa author: Atallah, Bassam title: A Marker of Systemic Inflammation or Direct Cardiac Injury: Should Cardiac Troponin Levels be Monitored in COVID-19 Patients? date: 2020-04-29 words: 1692 flesch: 38 summary: Interestingly, the median time from illness onset to acute cardiac injury among nonsurvivors was 14.5 days, compared to only one incidence of acute cardiac injury in survivors, which took place 21 days post-illness onset. Cardiologists as well as multidisciplinary teams involved in the care of COVID-19 patients are encouraged to participate in cardiac registries such as CAPACITY-COVID to better our collective understanding of the disease's implications. keywords: cardiac; covid-19; disease; levels; patients cache: cord-270327-v4td3zsa.txt plain text: cord-270327-v4td3zsa.txt item: #1014 of 2876 id: cord-270348-5804ffwx author: Angelino, Andrew F. title: Design and implementation of a regional inpatient psychiatry unit for asymptomatic SARS-CoV-2 positive patients. date: 2020-07-02 words: 5821 flesch: 56 summary: The PAPR can be worn without a mask, allowing the patient to see the provider's face, which we think is comforting to psychiatric patients, so we most often use PAPRs on the unit. Dr. Weiser had opened a psychiatric unit at his hospital to receive SARS-CoV-2 infected patients without COVID-19 patients from all other hospitals in Israel 6 , just as we sought to do for Maryland. keywords: care; cov-2; covid-19; inpatient; medical; patients; ppe; psychiatry; rooms; sars; staff; unit cache: cord-270348-5804ffwx.txt plain text: cord-270348-5804ffwx.txt item: #1015 of 2876 id: cord-270388-nozh463l author: Damiani, M. title: Extracorporeal Cytokine Hemadsorption in Severe COVID-19 Respiratory Failure date: 2020-06-29 words: 1052 flesch: 47 summary: Chronic Dis Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology Use of siltuximab in patients with COVID-19 pneumonia requiring ventilatory support Hemoadsorption by CytoSorb in septic patients: A case series Food and Drug Administration. In this study we report for the first time that CytoSorb treatment for 24-48 hours significantly reduces IL-6 levels resulting in a beneficial effect on systemic inflammation in the subsequent days. keywords: cytosorb; patients; preprint; treatment cache: cord-270388-nozh463l.txt plain text: cord-270388-nozh463l.txt item: #1016 of 2876 id: cord-270391-703js942 author: Rai, Harpreet K title: Atypical Presentation of Panhypopituitarism date: 2020-07-09 words: 1704 flesch: 40 summary: Hypopituitarism can present as a deficiency of individual anterior pituitary hormones (e.g., adrenocorticotropic hormone, thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, prolactin, growth hormone) or posterior pituitary hormones (e.g., oxytocin, vasopressin) or as the deficiency of all these pituitary hormones, also known as panhypopituitarism. Patients admitted to the hospital for further workup of syncope usually undergo an extensive cardiac and neurological assessment. keywords: deficiency; mass; patient; pituitary; syncope cache: cord-270391-703js942.txt plain text: cord-270391-703js942.txt item: #1017 of 2876 id: cord-270509-roc93m4f author: Radhakrishnan, Suma title: Guidelines for Surgical Tracheostomy and Tracheostomy Tube Change During the COVID-19 Pandemic: A Review Article date: 2020-06-22 words: 1525 flesch: 51 summary: A range of cuffed non-fenestrated sets of tracheostomy tubes to be kept ready in OR and to be replaced after surgery. We also did explore the current literature and recommendations for tracheostomy in patients with COVID-19 and studied the previous data from severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), the virus responsible for the SARS outbreak of 2003. keywords: covid-19; patients; tracheostomy; tube; ventilator cache: cord-270509-roc93m4f.txt plain text: cord-270509-roc93m4f.txt item: #1018 of 2876 id: cord-270525-nmebqrb1 author: Núñez-Velasco, Santiago title: Response to SARS-CoV-2 Pandemic in a Non-COVID-19 Designated Latin-American Neurosurgery Department date: 2020-05-11 words: 2666 flesch: 49 summary: To correctly use this algorithm, we have defined a screening questionnaire ( Table 1 ) that includes the epidemiological, radiological, serum, and clinical criteria commonly described in COVID-19 patients and that are readily available in our hospital this questionnaire allows us to classify patients at high and low risk of developing COVID-19; this form must be completed by the team of on-call neurosurgery residents and reported to the attendings team on duty for verification. We classified neurosurgical patients into 4 groups depending on whether their condition demands care in 0-6 hours, 6-48 hours, 48 hours to 14 days, and >14 days. keywords: care; case; covid-19; department; patients; risk cache: cord-270525-nmebqrb1.txt plain text: cord-270525-nmebqrb1.txt item: #1019 of 2876 id: cord-270628-jtj30v0r author: Alharthy, Abdulrahman title: Prospective Longitudinal Evaluation of Point‐of‐Care Lung Ultrasound in Critically Ill Patients With Severe COVID‐19 Pneumonia date: 2020-08-14 words: 4261 flesch: 41 summary: Is there a role for lung ultrasound during the COVID-19 pandemic? Proposal for international standardization of the use of lung ultrasound for COVID-19 patients; a simple, quantitative, reproducible method Point-of-care lung ultrasound in patients with COVID-19: a narrative review It's not over until it's over: the chameleonic behavior of COVID-19 over a six-day period COVID-19 outbreak: less stethoscope, more ultrasound Extension of coronavirus disease 2019 (COVID-19) on chest CT and implications for chest radiograph interpretation Relevance of lung ultrasound in the diagnosis of acute respiratory failure Bedside ultrasound assessment of positive end-expiratory pressureinduced lung recruitment Training for lung ultrasound score measurement in critically ill patients Ultrasound of the lungs more than a room with a view Ultrasonography for the assessment of lung recruitment maneuvers Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress Inter-rater reliability of quantifying pleural B-lines using multiple counting methods Diagnostic accuracy of chest radiograph, and when concomitantly studied lung ultrasound, in critically ill patients with respiratory symptoms: a systematic review and meta-analysis Lung ultrasound in the diagnosis and follow-up of community-acquired pneumonia: a prospective, multicenter, diagnostic accuracy study Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2 Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT Clinical and high-resolution CT features of the COVID-19 infection: comparison of the initial and follow-up changes Proposal of a low-dose, long-pitch, dual-source chest CT protocol on third-generation dual-source CT using a tin filter for spectral shaping at 100 kVp for coronavirus disease 2019 (COVID-19) patients: a feasibility study Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding China Medical Treatment Expert Group for COVID-19. World Federation for Ultrasound in Medicine and Biology position statement: how to perform a safe ultrasound examination and clean equipment in the context of COVID-19 Lower-extremity Doppler for deep venous thrombosis: can emergency physicians be accurate and fast? Accuracy of ultrasonography performed by critical care physicians for the diagnosis of DVT Incidence of thrombotic complications in critically ill ICU patients with COVID-19 ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Autopsy findings and venous thromboembolism in patients with COVID-19 Post-mortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Severe pulmonary embolism in COVID-19 patients: a call for increased awareness Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study Acute kidney injury in the intensive care unit according to RIFLE Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention A trial of lopinavir-ritonavir in adults hospitalized with Severe COVID-19 Sonographic signs and patterns of COVID-19 pneumonia. keywords: admission; coronavirus; covid-19; findings; icu; lung; patients; pneumonia; pocus; study; ultrasound cache: cord-270628-jtj30v0r.txt plain text: cord-270628-jtj30v0r.txt item: #1020 of 2876 id: cord-270654-cz2y6ta9 author: Deftereos, Spyridon G. title: The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design date: 2020-04-03 words: 2116 flesch: 30 summary: Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. keywords: acute; colchicine; covid-19; inflammasome; nlrp3; patients; study cache: cord-270654-cz2y6ta9.txt plain text: cord-270654-cz2y6ta9.txt item: #1021 of 2876 id: cord-270665-z4l3lq39 author: Tian, Qing title: Endoscopic mask innovation and protective measures changes during the COVID‐19 pandemic: experience from a Chinese hepato‐biliary‐pancreatic unit date: 2020-07-23 words: 1835 flesch: 33 summary: According to epidemiological investigations, the main source of infection is patients with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which may also include asymptomatic infection 2, 3 . Therefore, to minimize infections among patients and medical personnel, identifying an orderly and safe method for emergency endoscopy treatments has become an urgent concern. keywords: article; covid-19; endoscopy; infection; patients; treatment cache: cord-270665-z4l3lq39.txt plain text: cord-270665-z4l3lq39.txt item: #1022 of 2876 id: cord-270712-v6nnnzhm author: Woodcock, J. A. title: Test, test, test! date: 2020-06-26 words: 1680 flesch: 53 summary: In dental practice the vast majority of dental patients are booked as 'elective' patients. While dentists can continue support for these patients, future education and collaboration with our medical colleagues in primary care must also be considered in order to improve patient access, and ensure holistic patient care is being provided across all clinical settings. keywords: care; dentistry; patients; risk; test cache: cord-270712-v6nnnzhm.txt plain text: cord-270712-v6nnnzhm.txt item: #1023 of 2876 id: cord-270723-cjfglili author: Fteiha, Bashar title: QTc prolongation among hydroxychloroquine sulfate‐treated COVID‐19 patients: An observational study date: 2020-10-15 words: 3324 flesch: 46 summary: An open-label nonrandomized (nowadays controversial) trial also showed that HCQ treatment was associated with a significant reduction in viral shedding, an effect reportedly accentuated by concomitant treatment with azithromycin in six patients 4 . Data collection and variables: All relevant demographic, clinical and laboratory data (including additional medications which could potentially prolong QTc interval, prescribed throughout hospitalization and overlapped with HCQ treatment) were collected from the electronic medical record (EMR). keywords: covid-19; hcq; interval; patients; prolongation; qtc; treatment cache: cord-270723-cjfglili.txt plain text: cord-270723-cjfglili.txt item: #1024 of 2876 id: cord-270740-3su8pc3f author: Sultan, Sherif title: COVID-19 Cytokine Storm and Novel Truth date: 2020-05-22 words: 2383 flesch: 50 summary: Recurrent admission for post-hypoxic leukoencephalopathy strengthens the findings of the Italians, Spanish and Americans(4) that COVID-19 patients are suffering from metabolic hypoxia due to blood capacity failure. In COVID-19 patients, unlike with CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry oxygen. keywords: blood; coronavirus; covid-19; novel; oxygen; patients; storm cache: cord-270740-3su8pc3f.txt plain text: cord-270740-3su8pc3f.txt item: #1025 of 2876 id: cord-270763-idkylpb6 author: Fontes, Cristina Asvolinsque Pantaleão title: Influenza A virus H1N1 associated pneumonia - acute and late aspects evaluated with high resolution tomography in hospitalized patients date: 2020-09-30 words: 3931 flesch: 40 summary: A infection High-resolution computed tomography findings from adult patients with Influenza A (H1N1) virusassociated pneumonia Pandemic influenza (H1N1) viral pneumonia without co-infection in Korea: chest CT findings Pneumonia and respiratory failure from swine-origin Influenza A (H1N1) in Mexico Viral pneumonias in adults: radiologic and pathologic findings Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors Swine flu fibrosis: Regressive or progressive? Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic Organizing pneumonia as a late abnormality in influenza A (H1N1) virus infection Organizing pneumonia associated with swine-origin Influenza A H1N1 2009 viral infection Chest radiography and CT findings in patients with the 2009 pandemic (H1N1) influenza Clinical and radiographic comparison of influenza virus-associated pneumonia among three viral subtypes Pulmonary complication of novel influenza A(H1N1) infection: imaging features in two patients Measuring vaccine hesitancy, confidence, trust and flu vaccine uptake: Results of a national survey of white and African American adults Swine-origin influenza A (H1N1) viral infection: small airways disease Making universal influenza vaccines: lessons from the 1918 pandemic How imaging should properly be used in COVID-19 outbreak: an Italian experience Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China CT Imaging features of 2019 novel coronavirus (2019-nCoV) Thin-section chest CT imaging of coronavirus disease 2019 pneumonia: comparison between patients with mild and severe disease Chest computed tomography findings in COVID-19 and influenza: A narrative review flu season: Flu activity elevated nationally Global influenza strategy 2019-2030. We are grateful to the entire team involved in the care of patients with influenza A (H1N1) at the hospital and the diagnostic imaging service, that dealt with several patients almost above human capacity. keywords: findings; glass; ground; h1n1; influenza; patients; phase; pneumonia cache: cord-270763-idkylpb6.txt plain text: cord-270763-idkylpb6.txt item: #1026 of 2876 id: cord-270776-oulnk1b3 author: Chau, Tai-nin title: Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome date: 2004-08-15 words: 2776 flesch: 40 summary: Patients with more than two zones of lung involvement presented significantly later than patients with fewer zones of involvement (6 Ϯ 3 days vs. 4 Ϯ 2 days after onset of symptoms, P ϭ 0.001) Philadelphia Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study Defining prognostic factors in the elderly with community acquired pneumonia: a case controlled study of patients aged Ͼ or ϭ 75 yrs Simplified prediction rule for prognosis of patients with severe community-acquired pneumonia in ICUs Severe Acute Respiratory Syndrome: radiographic appearances and pattern of progression in 138 patients Clinical features and short-term outcomes of 144 patients with SARS in the Greater Toronto area Quantitative analysis and prognostic implication of SARS-coronavirus RNA in the plasma and serum of patients with severe acute respiratory syndrome Interobserver variability in applying a radiographic definition for ARDS Severe Acute Respiratory Syndrome (SARS) in Singapore: clinical features of index patient and initial contacts Prognostic Features of Chest Radiographs in SARS/Chau et al keywords: acute; chest; involvement; patients; sars; zones cache: cord-270776-oulnk1b3.txt plain text: cord-270776-oulnk1b3.txt item: #1027 of 2876 id: cord-270799-2pmpspuj author: Zayet, Souheil title: Clinical features of COVID-19 and influenza: A comparative study on Nord Franche-Comte cluster date: 2020-06-16 words: 2852 flesch: 48 summary: In two groups patients without fever or a feeling of 136 fever were scarce: 4 patients in COVID-19 group and 1 patient in influenza group (p=0,386). However, 137 fever ≥38°C was significantly higher in influenza group than COVID-19 group (93% vs 76% 138 respectively, p=0.042) but the mean highest temperature was not significantly different (39°C vs 139 38.7°C respectively; p=0.064). keywords: covid-19; days; group; influenza; patients; symptoms cache: cord-270799-2pmpspuj.txt plain text: cord-270799-2pmpspuj.txt item: #1028 of 2876 id: cord-270876-kul6bs3w author: Morris, Nathaniel P. title: Virtual Visits and the Future of No-Shows date: 2020-06-08 words: 1302 flesch: 48 summary: Now, as our clinic shifts to virtual visits amid the coronavirus disease 2019 (COVID-19) pandemic, I find myself routinely talking with patients in their cars, their closets, and their backyards. By allowing patients to remotely attend appointments through audiovisual applications, virtual visits bring promise for decreasing outpatient no-shows. keywords: appointments; patients; visits cache: cord-270876-kul6bs3w.txt plain text: cord-270876-kul6bs3w.txt item: #1029 of 2876 id: cord-270933-ecmg8kti author: Ali, Ashaq title: COVID-19: Clinical aspects and therapeutics responses date: 2020-07-03 words: 1657 flesch: 43 summary: We found the new combination is very effective against patients with mild symptoms and asymptomatic patients. The major ingredients of LH consisted of Lonicera japonica, Forsythia suspensa, Isatis indigotica , Ephedra sinica, combination with the antiviral drug for COVID-19 in asymptomatic patients or patients with mild symptoms. keywords: covid-19; patients; symptoms cache: cord-270933-ecmg8kti.txt plain text: cord-270933-ecmg8kti.txt item: #1030 of 2876 id: cord-271149-qnhlfozo author: Huo, Xiang title: Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014 date: 2016-09-01 words: 3680 flesch: 41 summary: Finally, the combination of disease severity, proportion of reimbursement and family member monthly average income was found to be associated with patients hospitalization fee with best goodness of fit (Additional file 2: Table S1 ). Furthermore, the combination of disease severity, reimbursement proportion and family member monthly average income was found to be associated with patient's hospitalization fee and these factors should be addressed in making related health insurance policies. keywords: costs; direct; disease; fees; h7n9; hospitalization; patients; study cache: cord-271149-qnhlfozo.txt plain text: cord-271149-qnhlfozo.txt item: #1031 of 2876 id: cord-271180-cnrs0zpg author: Rizvi, Saniya title: Cytosorb Filter: An adjunct for survival in the COVID-19 patient in cytokine storm? A case report. date: 2020-09-18 words: 3900 flesch: 47 summary: 2 It has been successfully used in cytokine storm patients previously with septic shock, severe pro-inflammatory state in post-operative conditions. Chest x-ray on hospital day 11 which coincided with the first day of cytokine filter therapy showing persistence of infiltrates, improved aeration and improved right lower lobe consolidation. keywords: blood; covid-19; cytokine; day; filter; hospital; patient; renal; storm; therapy cache: cord-271180-cnrs0zpg.txt plain text: cord-271180-cnrs0zpg.txt item: #1032 of 2876 id: cord-271212-y8denvju author: Xu, Xia title: Analysis of inflammatory parameters and disease severity for 88 hospitalized COVID-19 patients in Wuhan, China date: 2020-07-25 words: 3103 flesch: 47 summary: COVID-19 patients were diagnosed through the symptoms and computed tomography (CT) image combining the detection of 2019-nCoV RNA or the specific virus IgM and IgG antibody to COVID-19. The study population included 88 confirmed and hospitalized COVID-19 patients. keywords: china; clinical; coronavirus; covid-19; disease; patients; severity; study cache: cord-271212-y8denvju.txt plain text: cord-271212-y8denvju.txt item: #1033 of 2876 id: cord-271220-sntawlnf author: Tadic, Marijana title: COVID‐19 and diabetes: Is there enough evidence? date: 2020-05-29 words: 2434 flesch: 33 summary: In one of the largest study published (n = 1099) so far, diabetes was present in 7.4% of COVID-19 patients and it was significantly more prevalent in patients with severe form of disease and those who experienced primary outcome end point (admission to an intensive care unit, the use of mechanical ventilation, or death). The same group of authors in a larger group of COVID-19 patients (n = 1590) reported diabetes in 8.2%, and it was significantly more prevalent among COVID-19 patients with severe form than in patients with non-severe form of disease (34.6% vs 14.3%). keywords: covid-19; diabetes; disease; patients cache: cord-271220-sntawlnf.txt plain text: cord-271220-sntawlnf.txt item: #1034 of 2876 id: cord-271262-xglhx928 author: Ghia, Samit title: “ANESTHESIA STAT” TO INTUBATE A COVID-19 PATIENT: IMPLICATIONS FOR THE ANESTHESIOLOGIST date: 2020-05-15 words: 3281 flesch: 35 summary: Opioids are an option in inducing COVID-19 patients; however, large fentanyl doses have been associated with post-induction hypotension, possibly due to sympathetic attenuation, which could be significantly pronounced and devastating in septic patients [12] . Although reducing exposure of medical personnel is of obvious importance, there has been a dearth of literature discussing clinical strategies during the induction and intubation of COVID-19 patients. keywords: airway; anesthesiologist; covid-19; exposure; induction; intubation; patients; room cache: cord-271262-xglhx928.txt plain text: cord-271262-xglhx928.txt item: #1035 of 2876 id: cord-271358-5666nsb9 author: Roncon, Loris title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-06 words: 420 flesch: 33 summary: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis Thrombocytopenia and its association with mortality in patients with COVID-19 Loris Roncon and Marco Zuin are equally contributed to the manuscript as first author Exploring possible mechanisms for COVID-19 induced thrombocytopenia: unanswered questions key: cord-271358-5666nsb9 authors: Roncon, Loris; Zuin, Marco; Rigatelli, Gianluca title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-06 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02358-4 sha: doc_id: 271358 cord_uid: 5666nsb9 nan We read with great interest the article by Testa et al. regarding the replacement of oral anticoagulant therapies (VKA and DOAC) with parenteral heparin to avoid the risk of overor undertreatment [1] . keywords: patients cache: cord-271358-5666nsb9.txt plain text: cord-271358-5666nsb9.txt item: #1036 of 2876 id: cord-271483-33kuvpl7 author: Shojaei, Amirahmad title: COVID-19 and off label use of drugs: an ethical viewpoint date: 2020-05-08 words: 3185 flesch: 38 summary: key: cord-271483-33kuvpl7 authors: Shojaei, Amirahmad; Salari, Pooneh title: COVID-19 and off label use of drugs: an ethical viewpoint date: 2020-05-08 journal: Daru DOI: 10.1007/s40199-020-00351-y sha: doc_id: 271483 cord_uid: 33kuvpl7 BACKGROUND: They may apply so many different off-label medications even the ones with the weakest evidence in hope of rescuing COVID-19 positive patients, whose life is seriously threatening. keywords: covid-19; label; medications; patients; practice; research; use cache: cord-271483-33kuvpl7.txt plain text: cord-271483-33kuvpl7.txt item: #1037 of 2876 id: cord-271603-zy4l9vtf author: Skali, Hicham title: Guidance and Best Practices for Reestablishment of Non-Emergent Care in Nuclear Cardiology Laboratories During the Coronavirus Disease 2019 (COVID-19) Pandemic: An Information Statement from ASNC, IAEA, and SNMMI date: 2020-10-17 words: 3729 flesch: 39 summary: During the COVID-19 pandemic, many trainees have been redeployed from their imaging rotations to clinical care of COVID-19 patients in the hospital and intensive care units. The American Society of Nuclear Cardiology (ASNC) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) issued an Information Statement 3 with guidance for nuclear cardiology laboratories during the COVID-19 pandemic in late March 2020 that also recommended delaying all non-urgent studies. keywords: cardiology; covid-19; healthcare; laboratories; laboratory; pandemic; patients; stress; testing cache: cord-271603-zy4l9vtf.txt plain text: cord-271603-zy4l9vtf.txt item: #1038 of 2876 id: cord-271660-5sfkhg19 author: Sun, Hsin-Yun title: Impact of introducing fluorescent microscopy on hospital tuberculosis control: A before-after study at a high caseload medical center in Taiwan date: 2020-04-03 words: 3893 flesch: 35 summary: Contact investigation had been expanded to all HCWs who were exposed to TB patients since 2004. In keeping with previous observations (S3 Table) , the absence of cough and other typical symptoms is a barrier to prompt respiratory isolation of TB patients (S2 Table) . keywords: isolation; microscopy; patients; respiratory; risk; smear; tuberculosis cache: cord-271660-5sfkhg19.txt plain text: cord-271660-5sfkhg19.txt item: #1039 of 2876 id: cord-271871-8grkln6o author: Singer, J. S. title: Low Prevalence (0.13%) of COVID-19 Infection in Asymptomatic Pre-operative/Pre-procedure Patients at a Large Academic Medical Center Informs Approaches to Perioperative Care date: 2020-08-14 words: 2844 flesch: 36 summary: The overall very low numbers of COVID-19 positive patients in our data set 374 preclude the ability to extrapolate significance of this finding. The prevalence of asymptomatic COVID-19 infection was 0.13%. keywords: asymptomatic; covid-19; infection; patients; pre; procedures; testing cache: cord-271871-8grkln6o.txt plain text: cord-271871-8grkln6o.txt item: #1040 of 2876 id: cord-271887-blwrpf38 author: Sampa, Masuda Begum title: Redesigning Portable Health Clinic Platform as a Remote Healthcare System to Tackle COVID-19 Pandemic Situation in Unreached Communities date: 2020-06-30 words: 5658 flesch: 43 summary: Public health experts are working at relieving pressure on healthcare facilities so resources can be focused on COVID-19 patients. Moreover, findings indicate that frontline medical staff experience heightened levels of stress when coming into direct contact with COVID-19 patients. keywords: covid-19; disease; health; healthcare; ncds; patients; people; phc; risk; services; system; worker cache: cord-271887-blwrpf38.txt plain text: cord-271887-blwrpf38.txt item: #1041 of 2876 id: cord-271896-1ad18z11 author: Janowitz, Tobias title: Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series date: 2020-06-04 words: 3629 flesch: 44 summary: key: cord-271896-1ad18z11 authors: Janowitz, Tobias; Gablenz, Eva; Pattinson, David; Wang, Timothy C; Conigliaro, Joseph; Tracey, Kevin; Tuveson, David title: Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series date: 2020-06-04 journal: Gut DOI: 10.1136/gutjnl-2020-321852 sha: doc_id: 271896 cord_uid: 1ad18z11 OBJECTIVE: Treatment options for non-hospitalised patients with coronavirus disease 2019 (COVID-19) to reduce morbidity, mortality and spread of the disease are an urgent global need. keywords: covid-19; days; famotidine; patients; scores; symptoms; times cache: cord-271896-1ad18z11.txt plain text: cord-271896-1ad18z11.txt item: #1042 of 2876 id: cord-271920-1dzkgt6w author: Carpenter, Christopher R. title: Diagnosing COVID‐19 in the Emergency Department: A Scoping Review of Clinical Exam, Labs, Imaging Accuracy and Biases date: 2020-06-16 words: 7256 flesch: 41 summary: For example, among COVID-19 patients from cruise ships evaluated with CT, those with symptoms more commonly had COVID-19 CT findings than those without symptoms (80% vs. 40%). Emergency departments (ED) encountered decreased patient volumes before some in Seattle, New York City, New Orleans, and Detroit experienced waves of COVID-19 patients mixed with asymptomatic patients or those concerned about potential exposures. keywords: accuracy; article; copyright; coronavirus; cov-2; covid-19; disease; negative; patients; pcr; rrt; sars; sensitivity; tests cache: cord-271920-1dzkgt6w.txt plain text: cord-271920-1dzkgt6w.txt item: #1043 of 2876 id: cord-271944-oxtus5vb author: Joseph, Rudman title: Seizure And COVID-19: Association and Review of Potential Mechanism date: 2020-10-13 words: 2363 flesch: 42 summary: We will be concluding the paper by briefly discussing the three possible seizure development mechanisms in patients infected with SARS- COV 2, which includes - (a) Direct Mechanism (b) Indirect Mechanism and (c) Exacerbation of Seizure in Patients with Epilepsy (PWE). We have discussed the electroencephalogram (EEG), imaging, and Cerebrospinal fluid (CSF) findings in COVID-19 patients presenting with seizure. keywords: coronavirus; cov-2; covid-19; patients; sars; seizures cache: cord-271944-oxtus5vb.txt plain text: cord-271944-oxtus5vb.txt item: #1044 of 2876 id: cord-272071-445ivhx0 author: Wunsch, Hannah title: Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology date: 2020-07-01 words: 2633 flesch: 40 summary: Severe steroid-resistant asthma affects 5-10% of adult patients, who disproportionately account for 50-80% of all asthma-associated healthcare costs (6) . key: cord-272071-445ivhx0 authors: Wunsch, Hannah title: Mechanical Ventilation in COVID-19: Interpreting the Current Epidemiology date: 2020-07-01 journal: Am J Respir Crit Care Med DOI: 10.1164/rccm.202004-1385ed sha: doc_id: 272071 cord_uid: 445ivhx0 nan The world is scrutinizing every cohort and every outcome for patients with coronavirus disease , particularly the most critically ill who are receiving mechanical ventilation. keywords: care; covid-19; data; mortality; patients; ventilation cache: cord-272071-445ivhx0.txt plain text: cord-272071-445ivhx0.txt item: #1045 of 2876 id: cord-272112-egsha2j7 author: Tartarone, Alfredo title: COVID-19 and cancer care: what do international guidelines say? date: 2020-08-07 words: 2415 flesch: 35 summary: modes -oftrans missi on-of-virus -causi ng-covid -19-impli catio ns-for-ipcpreca ution -recom menda tions Estimates of the severity of coronavirus disease 2019: a model-based analysis Clinical characteristics of CIVID-19 infected cancer patients: a retrospective case study in three hospitals within Wuhan Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China SARS-CoV-2 transmission in patients with cancer at a tertiary care hospital in Wuhan, China Characteristics of COVID-19 patients dying in Italy Case fatality rate of cancer patients with COVID-19 in a New York Hospital system Rischio infettivo da coronavirus COVID 19: indicazioni per l'oncologia La gestione delle pazienti con carcinoma mammario durante la pandemia COVID-19 versione 25 Aprile 2020 Consequently cancer patients are at very high risk for COVID-19 infection considering that they often present multiple risk factors as well as older age, immunosuppressed state due to anticancer treatment and several comorbidities (e.g., chronic lung disease, diabetes, cardiovascular diseases). keywords: cancer; covid-19; infection; pandemic; patients; risk; treatment cache: cord-272112-egsha2j7.txt plain text: cord-272112-egsha2j7.txt item: #1046 of 2876 id: cord-272135-a09bf50o author: Brouqui, Philippe title: Infection control in the management of highly pathogenic infectious diseases: consensus of the European Network of Infectious Disease date: 2009-04-22 words: 6631 flesch: 39 summary: The examination should be kept as short as possible to answer the clinical questions • For HLIU-admitted patients, bedside radiography should be provided to avoid transport of patients; radiographic equipment should then be kept in the HLIU • Radiographs should be interpreted only by a designated radiologist who is aware of infection-control procedures, and by use of a picture-archiving and communication system, if available 84 • For ultrasound scanning, a sonographic scanner should be designated as a portable radiograph to be used only for HID patients • For CT or MRI, we strongly recommend that the department appoints a staff member to monitor and ensure that all department staff fully comply with the infection-control measures according to the guidelines • Designated sessions or hours, either out of offi ce hours or at the end of a session, should be assigned for such patients • Treat HID patients who require dialysis at their bedside with either peritoneal dialysis or haemodialysis • Designate dedicated haemodialysis machines • Decontaminate dialysate as infectious waste Post-mortem examination • Risks and benefi ts must be carefully considered • Limited autopsy or post-mortem collection of blood and percutaneous biopsy are preferred • The topics selected were as follows: patient's criteria for admission to the HLIU, admission to the emergency department, safe sampling for laboratory investigation, isolation of suspected HID patient in HLIU, intensive-care management of HID patients, HID in paediatric patients, practice of invasive procedures such as bronchoscopy and gastroscopy, radio imaging, renal dialysis, and post-mortem examination of HID patients. keywords: care; control; health; hid; hliu; infection; isolation; laboratory; patients; respiratory; risk; sars; syndrome; transmission cache: cord-272135-a09bf50o.txt plain text: cord-272135-a09bf50o.txt item: #1047 of 2876 id: cord-272143-6ej3eibd author: Benavides‐Nieto, Marta title: The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy date: 2018-12-21 words: 1878 flesch: 32 summary: 9, 10 In addition, there are several recent reports showing an increased susceptibility to viral respiratory infections in adults with CVID receiving IRT, 4-7 that can contribute to chronic and persistent pulmonary inflammation. 20,21 B-cell immune reconstitution and its consequences regarding viral respiratory infections have not been deeply investigated in these patients. keywords: children; immunodeficiency; infections; lung; patients; viruses cache: cord-272143-6ej3eibd.txt plain text: cord-272143-6ej3eibd.txt item: #1048 of 2876 id: cord-272154-nrm9ulj5 author: Gupta, Ravi title: Guidelines of the Indian Society for Sleep Research (ISSR) for Practice of Sleep Medicine during COVID-19 date: 2020-07-04 words: 5691 flesch: 53 summary: As sleep services resume operations, there is a need to find innovative ways to reduce contact with COVID-19 patients, follow personal protection guidelines, as well as social distancing. As sleep services resume operations, there is a need to find innovative ways to reduce contact with COVID-19 patients, travel, follow personal protection guidelines, as well as social distancing to prevent the spread of COVID-19 infection. keywords: consultation; covid-19; guidelines; medicine; pandemic; pap; patients; practice; sleep; teleconsultation; therapy; use cache: cord-272154-nrm9ulj5.txt plain text: cord-272154-nrm9ulj5.txt item: #1049 of 2876 id: cord-272318-8yfg1j0o author: Reddy, Sujan T. title: Cerebrovascular Disease in Patients with COVID-19: A Review of the Literature and Case Series date: 2020-06-11 words: 3399 flesch: 39 summary: In addition, patients with severe pneumonia (as defined by American Thoracic Society guidelines for community-acquired pneumonia) from COVID-19 infection were also more likely to develop new-onset CVD. Viral neurotropism, endothelial dysfunction, coagulopathy and inflammation are plausible proposed mechanisms of CVD in COVID-19 patients. keywords: brain; case; covid-19; cvd; disease; infection; patients; series; stroke cache: cord-272318-8yfg1j0o.txt plain text: cord-272318-8yfg1j0o.txt item: #1050 of 2876 id: cord-272419-y3ebt4jm author: Monari, Caterina title: A Focus on the Nowadays Potential Antiviral Strategies in Early Phase of Coronavirus Disease 2019 (Covid-19): A Narrative Review date: 2020-08-09 words: 6494 flesch: 40 summary: However, currently, there are very few data regarding the efficacy and safety profile of DRV/c in COVID-19 patients. However, a recent paper by Stauffer et al. has highlighted the relevant role that ivermectine may play in COVID-19 patients in preventing Strongyloides hyperinfection, which is a potential fatal complication secondary to the administration of dexamethasone [77] . keywords: coronavirus; cov-2; covid-19; efficacy; hcq; infection; lpv; patients; remdesivir; sars; study; treatment; trial cache: cord-272419-y3ebt4jm.txt plain text: cord-272419-y3ebt4jm.txt item: #1051 of 2876 id: cord-272427-jqs00ilp author: Li, Yu-xuan title: The impact of COVID-19 on gastric cancer surgery: a single-center retrospective study date: 2020-10-02 words: 2658 flesch: 47 summary: Due to the prevailing pandemic, we propose some surgical strategies for gastric cancer patients. Based on our experiences during the pandemic period, we propose some surgical strategies for gastric cancer patients. keywords: cancer; covid-19; hospital; patients; period; surgery cache: cord-272427-jqs00ilp.txt plain text: cord-272427-jqs00ilp.txt item: #1052 of 2876 id: cord-272553-bcmta2he author: Wang, Zhiqiang title: Clinical characteristics and laboratory results of pregnant women with COVID‐19 in Wuhan, China date: 2020-07-03 words: 1666 flesch: 39 summary: 8, 9 This may be one reason that the pandemic spread so quickly at The present study also found that the typical symptoms of COVID-19 may have been milder in pregnant patients than in nonpregnant patients, which was also reported in an earlier study. The WHO-report on the COVID-19 outbreak in China What are the risks of COVID-19 infection in pregnant women? Management of pregnant women infected with COVID-19 COVID-19 in pregnant women Detection and analysis of nucleic acid in various biological samples of COVID-19 patients The role of chest imaging in patient management during the COVID-19 pandemic: A multinational consensus statement from the Fleischner Society The 5th edition of diagnosis and treatment program of COVID-19 pneumonia from the National Health Commission Coronavirus infections-more than just the common cold A new coronavirus associated with human respiratory disease in China Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing COVID-19: What is next for public health? Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection Characteristics of peripheral blood leukocyte differential counts in patients with COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Procalcitonin-guided antibiotic therapy in patients with fever in a general emergency department population: A multicentre non-inferiority randomized clinical trial (HiTEMP study) Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19 Chest CT manifestations of new coronavirus disease 2019 (COVID-19): A pictorial review keywords: covid-19; patients; results; study cache: cord-272553-bcmta2he.txt plain text: cord-272553-bcmta2he.txt item: #1053 of 2876 id: cord-272585-346ef6qy author: Lombardi, JM title: Addressing a National Crisis: The Spine Hospital and Department's Response to the COVID-19 Pandemic in New York City date: 2020-05-31 words: 5081 flesch: 47 summary: To date, our hospital has treated thousands of COVID-19 positive patients and sits at the forefront of the United States response to this pandemic. Published data by healthcare providers in Asia and Europe demonstrated that the most substantial threat to COVID-19 patient morbidity and mortality was the lack of adequate critical care resources including intensive care unit (ICU) beds and respiratory support [8] [9] . keywords: care; cases; covid-19; department; health; hospital; new; operating; pandemic; patients; room; spine cache: cord-272585-346ef6qy.txt plain text: cord-272585-346ef6qy.txt item: #1054 of 2876 id: cord-272630-2na1gndu author: Benito, Daniel A. title: Local spikes in COVID-19 cases: Recommendations for maintaining otolaryngology clinic operations date: 2020-08-20 words: 2089 flesch: 37 summary: key: cord-272630-2na1gndu authors: Benito, Daniel A.; Pasick, Luke; Mulcahy, Collin F.; Rajasekaran, Karthik; Todd-Hesham, Hosai; Joshi, Arjun S.; Goodman, Joseph F.; Thakkar, Punam title: Local spikes in COVID-19 cases: Recommendations for maintaining otolaryngology clinic operations date: 2020-08-20 journal: Am J Otolaryngol DOI: 10.1016/j.amjoto.2020.102688 sha: doc_id: 272630 cord_uid: 2na1gndu The Coronavirus Disease-2019 (COVID-19) pandemic has created an unprecedented economic and public health crisis in the United States. As otolaryngologists prepare to weather the storm of impending local surges in COVID-19 infections there are several practical measures that can be taken to mitigate the risk to ourselves and our staff. keywords: covid-19; otolaryngology; patients; procedures; recommendations; staff cache: cord-272630-2na1gndu.txt plain text: cord-272630-2na1gndu.txt item: #1055 of 2876 id: cord-272655-qeojdpez author: Remolina, Yuly Andrea title: Viral Infection in Adults with Severe Acute Respiratory Infection in Colombia date: 2015-11-17 words: 4310 flesch: 37 summary: Furthermore, current challenges in the epidemiological surveillance of viral respiratory tract infections include the early and fast identification of aetiological agents, especially at the beginnings of outbreaks, and the optimal and timely management of a large number of samples [14] . Results from a prospective, population-based study Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults Bacterial complications of respiratory tract viral illness: a comprehensive evaluation Estimates of mortality attributable to influenza and RSV in the United States during 1997-2009 by influenza type or subtype, age, cause of death, and risk status Roles of humidity and temperature in shaping influenza seasonality Epidemiology and seasonality of respiratory tract virus infections in the tropics Utilization of nucleic acid amplification assays for the detection of respiratory viruses Comparative evaluation of effectiveness of IAVchip DNA microarray in influenza A diagnosis Microorganisms in respiratory tract of patients diagnosed with atypical pneumonia: results of a research based on the use of reverse transcription polymerase chain reaction (RT-PCR) DNA microarray method and enzyme-linked immunosorbent assay The clinical utility of a near patient care rapid microarray-based diagnostic test for influenza and respiratory syncytial virus infections in the pediatric setting Multi-center evaluation of the adenovirus R-gene US assay for the detection of adenovirus in respiratory samples Antibiotic prescribing in ambulatory care settings for adults with colds, upper respiratory tract infections, and bronchitis Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections A role for Streptococcus pneumoniae in virus-associated pneumonia keywords: cases; days; hospital; infections; influenza; patients; pneumonia; study; virus cache: cord-272655-qeojdpez.txt plain text: cord-272655-qeojdpez.txt item: #1056 of 2876 id: cord-272677-6t9kl3hq author: Wu, w. title: Key Points of Clinical and CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) Imported Pneumonia Based On 21 Cases Analysis date: 2020-03-06 words: 4093 flesch: 51 summary: In this study, CT features of NCP patients mainly displayed GGO (100%), vascular enlargement sign (76.5%) and cobblestone/reticular pattern (70.6%), as followed by consolidation and mixed pattern (GGO and consolidation) with about 52.9%. https://doi.org/10.1101/2020.03.03.20030775 doi: medRxiv preprint but also follow up the change trend of CT features can effectively predict the outcome of NCP patients. keywords: cases; features; group; ncp; patients; preprint cache: cord-272677-6t9kl3hq.txt plain text: cord-272677-6t9kl3hq.txt item: #1057 of 2876 id: cord-272727-a5ngjuyz author: Bertsimas, D. title: From predictions to prescriptions: A data-drivenresponse to COVID-19 date: 2020-06-29 words: 3599 flesch: 47 summary: We have 206 therefore initiated a multi-institution collaboration to collect 207 electronic medical records from COVID-19 patients and de-208 velop clinical risk calculators. Once the 223 burden on hot spots has ebbed, hospitals began to aggregate 224 rich data on COVID-19 patients. keywords: covid-19; data; disease; infection; model; mortality; pandemic; patients; policies; risk cache: cord-272727-a5ngjuyz.txt plain text: cord-272727-a5ngjuyz.txt item: #1058 of 2876 id: cord-272778-aixiioii author: Chen, Qingqing title: Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China date: 2020-04-28 words: 3027 flesch: 49 summary: CONCLUSIONS: Older patients or patients with comorbidities such as obesity or diabetes mellitus were more likely to have severe condition. Older patients or patients with comorbidities such as obesity or diabetes mellitus were more likely to have severe condition. keywords: china; clinical; covid-19; patients; pneumonia; study; taizhou cache: cord-272778-aixiioii.txt plain text: cord-272778-aixiioii.txt item: #1059 of 2876 id: cord-272975-gzsd4ybt author: Antony, Arun title: Systematic review of EEG findings in 617 patients diagnosed with COVID-19 date: 2020-10-19 words: 3558 flesch: 38 summary: However, a large study of 111 patients reported that EEG studies were performed after a median of 10.8 days after hospitalization. key: cord-272975-gzsd4ybt authors: Antony, Arun; Haneef, Zulfi title: Systematic review of EEG findings in 617 patients diagnosed with COVID-19 date: 2020-10-19 journal: Seizure DOI: 10.1016/j.seizure.2020.10.014 sha: doc_id: 272975 cord_uid: gzsd4ybt Objective We performed a systematic review of the literature to synthesize the data on EEG findings in COVID-19. keywords: covid-19; eeg; findings; patients; studies cache: cord-272975-gzsd4ybt.txt plain text: cord-272975-gzsd4ybt.txt item: #1060 of 2876 id: cord-272976-pb2bjpop author: Washington, Lacey title: ACR Appropriateness Criteria(®) on Acute Respiratory Illness date: 2009-10-01 words: 2857 flesch: 34 summary: The need for chest radiography in adult patients with acute asthma is controversial (Variant 7). [13] retrospectively analyzed computed tomographic scans and autopsy results in 96 cancer patients who died of pneumonia and found that the presence of nodules in neutropenic patients and cavitary lesions in nonneutropenic patients was highly associated with fungal infection. keywords: chest; findings; patients; pneumonia cache: cord-272976-pb2bjpop.txt plain text: cord-272976-pb2bjpop.txt item: #1061 of 2876 id: cord-273045-ele1cz86 author: Johnson, Claire D. title: Response of Practicing Chiropractors during the Early Phase of the COVID-19 Pandemic: A Descriptive Report date: 2020-06-13 words: 13970 flesch: 52 summary: For the chiropractors who practiced in solo practice, they assumed responsibility for the function of the office, including patient care, communications, and sanitation. 125 Health workers initially were only allowed to work if they worked with concerns related to COVID-19 patients. keywords: care; chiropractic; chiropractors; clinic; coronavirus; covid-19; government; health; health care; home; information; march; office; pandemic; patients; practice; public; regulations; services; staff; state; telehealth; time; treatment; visits cache: cord-273045-ele1cz86.txt plain text: cord-273045-ele1cz86.txt item: #1062 of 2876 id: cord-273090-fdzkfo1u author: He, Susu title: Relationship between Chest CT manifestations and immune response in COVID-19 patients date: 2020-06-20 words: 2841 flesch: 54 summary: There were 72 (77%) patients with elevated IL-6, of which 42 were in mild patients (70% of the mild group) and 30 were in severe patients (91% of the severe group). Among them, severe patients had much more chances of consolidation than mild patients, which was statistically different ( Table 3) . keywords: group; infection; lung; ncov; patients; study cache: cord-273090-fdzkfo1u.txt plain text: cord-273090-fdzkfo1u.txt item: #1063 of 2876 id: cord-273091-40gda9n9 author: Marrie, Thomas J. title: Empiric treatment of ambulatory community-acquired pneumonia: always include treatment for atypical agents date: 2005-03-01 words: 4368 flesch: 43 summary: [43] studied 105 patients who had CAP and found that 16 had Chlamydia pneumoniae pneumonia. [44] found that 21 of 47 (44.6%) patients who had Chlamydia pneumoniae pneumonia had a copathogen. keywords: cap; chlamydia; community; days; fever; patients; pneumonia; therapy; treatment cache: cord-273091-40gda9n9.txt plain text: cord-273091-40gda9n9.txt item: #1064 of 2876 id: cord-273119-jfy0iviy author: Julka-Anderson, Naman title: How COVID-19 is testing and evolving our communication skills date: 2020-06-25 words: 2276 flesch: 65 summary: To go one step further, cancer patients can endure some form of lockdown during their cancer journey. For me, the bond between cancer patients and radiation therapists has grown stronger. keywords: face; patients; review; telephone cache: cord-273119-jfy0iviy.txt plain text: cord-273119-jfy0iviy.txt item: #1065 of 2876 id: cord-273175-bao8xxe2 author: Tran, Viet-Thi title: COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date: 2020-08-06 words: 3862 flesch: 45 summary: About one quarter of patients would refuse any contact with symptomatic people (17.8% and 23.4% for occasional and COVID-19-related perceptions, context and attitudes of adults with chronic conditions frequent contacts, respectively). key: cord-273175-bao8xxe2 authors: Tran, Viet-Thi; Ravaud, Philippe title: COVID-19–related perceptions, context and attitudes of adults with chronic conditions: Results from a cross-sectional survey nested in the ComPaRe e-cohort date: 2020-08-06 journal: PLoS One DOI: 10.1371/journal.pone.0237296 sha: doc_id: 273175 cord_uid: bao8xxe2 BACKGROUND: To avoid a surge of demand on the healthcare system due to the COVID-19 pandemic, we must reduce transmission to individuals with chronic conditions who are at risk of severe illness with COVID-19. keywords: chronic; conditions; contacts; covid-19; participants; patients; people; risk cache: cord-273175-bao8xxe2.txt plain text: cord-273175-bao8xxe2.txt item: #1066 of 2876 id: cord-273283-gb0m6fue author: Altschul, David J. title: A novel severity score to predict inpatient mortality in COVID-19 patients date: 2020-10-07 words: 3373 flesch: 41 summary: Then, we determined that low risk patients (0-3 points) had a 11.8% risk of mortality, moderate risk patients (4-7 points) had a 39% risk of mortality and high-risk patients (> 7 points) had a 78% risk of mortality (Fig. 2B) . Furthermore, based on the risk categorization the probability of mortality was 11.8%, 39% and 78% for patient with low (0–3), moderate (4–6) and high (7–10) COVID-19 severity score. keywords: cohort; covid-19; hospital; mortality; patients; risk; score; severity; study cache: cord-273283-gb0m6fue.txt plain text: cord-273283-gb0m6fue.txt item: #1067 of 2876 id: cord-273317-2e3vmdx4 author: Shekhar, Rahul title: Neurological Complications Among Native Americans with COVID-19: Our Experience at a Tertiary Care Academic Hospital in the U.S. date: 2020-08-24 words: 1489 flesch: 50 summary: Patients who developed hemorrhagic or ischemic events were observed to have poor outcomes as compared to patients who developed seizures. Patients with confirmed COVID-19 infection at University of New Mexico hospital (UNMH) were screened for development of neurological complications during Feb 01 to April 29, 2020 via retrospective chart review. keywords: complications; covid-19; patients cache: cord-273317-2e3vmdx4.txt plain text: cord-273317-2e3vmdx4.txt item: #1068 of 2876 id: cord-273408-jtpaue0z author: Romeyke, Tobias title: COVID-19 Case Report: An 84-Year-Old Man with Exacerbation of Multiple Comorbidities Due to COVID-19 Managed by a Multidisciplinary Team Using Patient-Reported Outcomes date: 2020-08-21 words: 3053 flesch: 43 summary: Our objective here was to obtain data on COVID-19 patients with multiple health conditions who did not require invasive mechanical ventilation. Unusual clinical course BACKGROUND: When treating patients with comorbidities who are infected with severe acute respiratory syndrome as a result of SARS-CoV-2, it is crucial to offer multidisciplinary treatment that takes into consideration all of the health conditions with which they have been diagnosed. keywords: care; chronic; health; pain; patient; pros; sars; treatment cache: cord-273408-jtpaue0z.txt plain text: cord-273408-jtpaue0z.txt item: #1069 of 2876 id: cord-273426-55vu6b3u author: Iba, Toshiaki title: Coagulopathy of Coronavirus Disease 2019 date: 2020-05-26 words: 4539 flesch: 22 summary: Platelet counts in COVID-19 patients are variable depending on the reported studies. The potential for increases in platelet counts in COVID-19 patients is suspected to be caused by increased proinflammatory cytokines such as interleukin (IL)-1β and IL-6 produced by the macrophages and monocytes in the lung (26) , and activated platelets may contribute to the lung injury (27) . keywords: acute; coagulation; coagulopathy; coronavirus; covid-19; disease; levels; patients; thrombosis cache: cord-273426-55vu6b3u.txt plain text: cord-273426-55vu6b3u.txt item: #1070 of 2876 id: cord-273567-8fp3a9h8 author: Zipprich, Hannah M. title: Knowledge, Attitudes, Practices, and Burden During the COVID-19 Pandemic in People with Parkinson’s Disease in Germany date: 2020-05-29 words: 5377 flesch: 51 summary: Patients with limited knowledge were older (mean age, 74.4 years; SD = 7.2) than patients with good knowledge (mean age, 70.0 years; SD = 8.5) (p = 0.03). Patients who felt that they were very well informed about COVID-19 were more likely to search actively for further information (p = 0.03) than patients who felt that they were not sufficiently informed about COVID-19; in contrast, none of the five patients who felt that they were poorly informed about COVID-19 actively searched for information. keywords: covid-19; disease; information; knowledge; measures; parkinson; patients; study cache: cord-273567-8fp3a9h8.txt plain text: cord-273567-8fp3a9h8.txt item: #1071 of 2876 id: cord-273587-nja58vxw author: Rendeiro, A. F. title: Longitudinal immune profiling of mild and severe COVID-19 reveals innate and adaptive immune dysfunction and provides an early prediction tool for clinical progression date: 2020-09-09 words: 8918 flesch: 40 summary: Indeed, similar to previous reports 17, 18, 50 , T cells displayed an overall exhausted phenotype, with overexpression of VISTA, TIM3, LAG3, TIGIT, and PD-1 coinhibitory receptors in COVID-19 patient T cell populations. Quantification of immune cell populations is available as a Supplementary Table file. keywords: cells; covid-19; disease; donors; expression; figure; immune; license; medrxiv; patients; perpetuity; populations; preprint; september; severity; version cache: cord-273587-nja58vxw.txt plain text: cord-273587-nja58vxw.txt item: #1072 of 2876 id: cord-273602-cq276tj8 author: Bavishi, Chirag title: Acute myocardial injury in patients hospitalized with COVID-19 infection: A review date: 2020-06-06 words: 2121 flesch: 23 summary: Circulation ST-Segment Elevation in Patients with Covid-19 -A Case Series Clinical observation and management of COVID-19 patients Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis ACTT-1 Study Group Members. Remdesivir for the Treatment of Covid-19 -Preliminary Report Acute Cardiovascular Conditions During the COVID-19 Pandemic: A Multicenter Tertiary Care Experience Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19 Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19) COVID-19 and Renin Angiotensin Blockers: Current Evidence and Recommendations Wang Y et al 12 keywords: cardiac; clinical; coronavirus; covid-19; injury; myocardial; patients cache: cord-273602-cq276tj8.txt plain text: cord-273602-cq276tj8.txt item: #1073 of 2876 id: cord-273614-qmp2tqtb author: Tahir, Faryal title: Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): A Comprehensive Review date: 2020-05-08 words: 7182 flesch: 49 summary: This high viability time period on different surfaces can lead to indirect transmission of SARS-CoV-2 to healthy individuals if they come into contact with objects used on COVID-19 patients, such as stethoscope or thermometer [18] . To intercept fatality among COVID-19 patients, the authors suggested close monitoring of the cardiac functioning of all patients, especially the severe and critical ones, and to seek possible interventions for patients evincing features of abnormal cardiac injury keywords: cardiac; cases; coronavirus; cov-2; covid-19; disease; injury; levels; median; mortality; patients; sars cache: cord-273614-qmp2tqtb.txt plain text: cord-273614-qmp2tqtb.txt item: #1074 of 2876 id: cord-273641-8l57mnjt author: Sadr, Sara title: Isolated severe thrombocytopenia in a patient with COVID-19: A case report date: 2020-05-29 words: 1439 flesch: 40 summary: More importantly, isolated severe thrombocytopenia with no respiratory illness is rarely seen in COVID-19 patients. A 57-year-old woman, a pharmacist with considerable exposure to COVID-19 patients, presented to a clinic in Tehran with headache and malaise with the onset of 5 days prior to admission. keywords: covid-19; platelet; symptoms; thrombocytopenia cache: cord-273641-8l57mnjt.txt plain text: cord-273641-8l57mnjt.txt item: #1075 of 2876 id: cord-273695-p5p7kvpp author: Fominskiy, Evgeny V. title: Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy date: 2020-07-13 words: 3514 flesch: 50 summary: Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Data from 2002-2004 SARS epidemic revealed that 6.7% of patients with SARS developed acute kidney injury (AKI) and the mortality of SARS patients with AKI was 91.7% keywords: aki; covid-19; crrt; data; hospital; kidney; patients; risk; study cache: cord-273695-p5p7kvpp.txt plain text: cord-273695-p5p7kvpp.txt item: #1076 of 2876 id: cord-273758-hhd8xnve author: Ciardullo, S. title: Impact of diabetes on COVID-19-related in-hospital mortality: a retrospective study from Northern Italy date: 2020-08-10 words: 3408 flesch: 41 summary: Spread of SARS-CoV-2 in the Icelandic population Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention COVID-19 infection in Italian people with diabetes: lessons learned for our future (an experience to be used) Pathophysiology and management strategies for hyperglycemia for patients with acute illness during and following a hospital stay Patients with diabetes are at higher risk for severe illness from COVID-19 Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia-a systematic review, meta-analysis, and metaregression Diabetes is a risk factor for the progression and prognosis of COVID-19 Clinical characteristics and risk factors for mortality of COVID-19 patients with diabetes in Wuhan Severe obesity, increasing age and male sex are independently associated with worse in-hospital outcomes, and higher in-hospital mortality Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study Outcomes in patients with hyperglycemia affected by Covid-19: can we do more on glycemic control? A case-control study Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: the potential contribution to diabetes complications and cardiovascular disease Lack of efficacy of SGLT2-i in severe pneumonia related to novel coronavirus (nCoV) infection: no little help from our friends Renin-angiotensin-aldosterone system blockers and the risk of Covid-19 Age and multimorbidity predict death among COVID-19 patients Clinical characteristics and prognostic factors in COVID-19 patients aged≥ 80 years Acknowledgements Open access funding provided by Università degli Studi di Milano -Bicocca within the CRUI-CARE Agreement.. keywords: covid-19; diabetes; disease; hospital; mortality; patients; risk; study cache: cord-273758-hhd8xnve.txt plain text: cord-273758-hhd8xnve.txt item: #1077 of 2876 id: cord-273869-buavj9mm author: Rosés-Gibert, Pau title: Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain date: 2020-09-08 words: 1896 flesch: 46 summary: A novel coronavirus from patients with pneumonia in China WHO declares COVID-19 a pandemic Cutaneous manifestations in COVID-19: a first perspective Urticarial eruption in COVID-19 infection Viral exanthem in COVID-19, a clinical enigma with biological significance Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients COVID-19) infection-induced chilblains: a case report with histopathological findings A case of COVID-19 presenting in clinical picture resembling chilblains disease: first report from the Middle East Chilblain and acral purpuric lesions in Spain during covid confinement: retrospective analysis of 12 cases Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients Chilblain-like lesions on feet and hands during the COVID-19 pandemic Acral cutaneous lesions in the time of COVID-19 Acute acro-ischemia in the child at the time of COVID-19 Are chilblainlike acral skin lesions really indicative of COVID-19? key: cord-273869-buavj9mm authors: Rosés-Gibert, Pau; Gimeno Castillo, Javier; Saenz Aguirre, Amaia; De la Torre Gomar, Francisco Javier; Carnero González, Lucía; Martinez de Lagrán Alvarez de Arcaya, Zuriñe; Gonzalez-Perez, Ricardo title: Acral lesions in a pediatric population during the COVID-19 pandemic: a case series of 36 patients from a single hospital in Spain date: 2020-09-08 journal: keywords: covid-19; infection; lesions; manifestations; patients cache: cord-273869-buavj9mm.txt plain text: cord-273869-buavj9mm.txt item: #1078 of 2876 id: cord-273875-vpp0l6ij author: Johnson, Miguel title: Creating a ‘safe haven’ for the most vulnerable; Early Reports of Management Strategies for Breast Cancer Patients in the UK during the COVID -19 Pandemic times date: 2020-09-20 words: 767 flesch: 40 summary: Breast cancer patients may be further subcategorized into high priority (life threatening, clinically unstable), medium priority (non critical but delay > 6-8 weeks could affect outcomes), or low priority (stable condition allowing for delay of care) based on several factors such as type of cancer and comorbidities This included an extended invitation to all breast cancer units in south England to utilize our hospital to deliver surgical care to breast cancer patients by Breast & Oncoplastic led Consultants. keywords: breast; cancer cache: cord-273875-vpp0l6ij.txt plain text: cord-273875-vpp0l6ij.txt item: #1079 of 2876 id: cord-273913-xem3alih author: Marraha, Farah title: A Review of the Dermatological Manifestations of Coronavirus Disease 2019 (COVID-19) date: 2020-08-11 words: 4237 flesch: 47 summary: Clinical and pathological features in 20 COVID-19 patients Cutaneous signs in COVID-19 patients: a review Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19 Hyperinflammatory shock in children during COVID-19 pandemic Selfreported hand eczema in a hospital population e adverse skin reactions of health care workers using personal protective equipment for COVID-19 Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19 Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Should chloroquine and hydroxychloroquine be used to treat COVID-19? Healthcare institutions and policymakers developed various plans to control the pandemic, including preparing hospitals and clinics, developing a strategy for the identification of suspected COVID-19 cases, and implementing a strategy to reduce the spread [24] . keywords: cases; coronavirus; covid-19; disease; infection; lesions; manifestations; patients; sars; skin; syndrome cache: cord-273913-xem3alih.txt plain text: cord-273913-xem3alih.txt item: #1080 of 2876 id: cord-273929-kpcmy9x8 author: Shah, Jatin P. title: The impact of COVID‐19 on Head and Neck surgery, education, and training date: 2020-04-25 words: 2543 flesch: 50 summary: Many patients who are at low risk of recurrence can be followed by telemedicine on a video call. The day-to-day life is disrupted; regular patient care of diseases and cancers is in disarray, with the focus of medical care shifted to the management of patients with COVID-19. keywords: follow; head; neck; patients; surgery; training cache: cord-273929-kpcmy9x8.txt plain text: cord-273929-kpcmy9x8.txt item: #1081 of 2876 id: cord-273945-b1lekw47 author: Bongiovanni, Alberto title: Comment on ‘Reorganisation of medical oncology departments during the novel coronavirus disease-19 pandemic: a nationwide Italian survey” by Alice Indini et al. date: 2020-05-16 words: 609 flesch: 33 summary: telemedicine for covid-19 Efficacy and safety of 12-weekly versus 4-weekly zoledronic acid for prolonged treatment of patients with bone metastases from breast cancer (ZOOM): a phase 3, open-label, randomised, noninferiority trial Efficacy and safety of de-escalation bonemodifying agents for cancer patients with bone metastases: a systematic review and meta-analysis (6) In the present emergency we have developed different strategies for cancer patients, in particular those with BMs: keywords: covid-19; patients cache: cord-273945-b1lekw47.txt plain text: cord-273945-b1lekw47.txt item: #1082 of 2876 id: cord-273996-z5vlw6nm author: Di Dalmazi, Guido title: Comparison of the effects of lockdown due to COVID-19 on glucose patterns among children, adolescents, and adults with type 1 diabetes: CGM study date: 2020-10-28 words: 4899 flesch: 44 summary: Moreover, the study provides a stratification of adult patients, giving information of categories of patients at risk of worsening their glucose variability during lockdown, and their associated factors. The separate analysis in patients aged 18.0-25.9 years showed that young adult patients in this age range had a slightly different behavior in CGM metrics than older adults, supporting the differences highlighted in the T1D Exchange study. keywords: adults; cgm; children; glucose; lockdown; patients; t1d; time; variability cache: cord-273996-z5vlw6nm.txt plain text: cord-273996-z5vlw6nm.txt item: #1083 of 2876 id: cord-274008-p3st70u3 author: Mann, E. R. title: Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis date: 2020-06-16 words: 6008 flesch: 44 summary: This is the first detailed longitudinal analysis of COVID-19 patients of varying severity and outcome, revealing common features and aspects that track with severity. This is the first detailed longitudinal analysis of COVID-19 patients of varying severity and outcome, revealing common features and aspects that track with severity. keywords: admission; blood; cells; covid-19; data; disease; figure; immune; medrxiv; monocytes; patients; preprint; severity cache: cord-274008-p3st70u3.txt plain text: cord-274008-p3st70u3.txt item: #1084 of 2876 id: cord-274121-3w6kc0c9 author: Ramiro, Sofia title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 words: 5784 flesch: 43 summary: Control patients with COVID-19-associated CSS (same definition) were retrospectively sampled from the pool of patients (n=350) admitted between 7 March and 31 March, and matched one to one to treated patients on sex and age. control patients with coVid-19-associated css (same definition) were retrospectively sampled from the pool of patients (n=350) admitted between 7 march and 31 march, and matched one to one to treated patients on sex and age. keywords: care; control; covid-19; css; fees; group; hospital; mortality; patients; study; treatment; ventilation cache: cord-274121-3w6kc0c9.txt plain text: cord-274121-3w6kc0c9.txt item: #1085 of 2876 id: cord-274184-hm516x6p author: Elli, Luca title: Endoscopy during the Covid-19 outbreak: experience and recommendations from a single center in a high-incidence scenario date: 2020-04-27 words: 4847 flesch: 44 summary: To face the new scenario all the hospitals have been re-organised in order to reduce all the outpatient services and to devote almost all their personnel and resources to the management of Covid-19 patients. Establishing maximum prevention within the endoscopy unit is a necessary countermeasure to the large spectrum of signs and symptoms expressed by Covid-19 patients (fever, cough but also, in smaller percentages, nausea, vomiting, diarrhoea and even neurological symptoms) and the large quantity of asymptomatic carriers [1, 2, 27, 28] . keywords: coronavirus; cov-2; covid-19; endoscopy; infection; outbreak; patients; pcr; risk; route; sars cache: cord-274184-hm516x6p.txt plain text: cord-274184-hm516x6p.txt item: #1086 of 2876 id: cord-274199-3stjueja author: Baldi, Enrico title: COVID-19 kills at home: the close relationship between the epidemic and the increase of out-of-hospital cardiac arrests date: 2020-06-20 words: 4313 flesch: 38 summary: Pulmonary embolism in COVID-19 patients: awareness of an increased prevalence Reduced rate of hospital admissions for ACS during Covid-19 outbreak in Northern Italy Impacto de la pandemia de COVID-19 sobre la actividad asistencial en cardiología intervencionista en España Reduction in STsegment elevation cardiac catheterization laboratory activations in the United States during COVID-19 pandemic Primary coronary angioplasty compared with intravenous thrombolytic therapy for acute myocardial infarction: six-month follow up and analysis of individual patient data from randomized trials Covid-19-the law and limits of quarantine Characteristics of COVID-19 patients dying in Italy Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period We would like to thank all the Lombardia CARe researchers and all the EMS personnel. In addition, digestive symptoms (i.e. diarrhoea and vomiting) are present in a fair number of COVID-19 patients, especially in those with mild disease severity, with a delayed diagnosis and treated at home, 32 and they were also experienced by 7% of the suspected or diagnosed COVID-19 patients in our cohort. keywords: 2019; cardiac; covid-19; ems; epidemic; incidence; increase; ohca; patients cache: cord-274199-3stjueja.txt plain text: cord-274199-3stjueja.txt item: #1087 of 2876 id: cord-274245-pgfqkwqg author: Rali, Aniket S title: Cardiopulmonary Ultrasonography for Severe Coronavirus Disease 2019 Patients in Prone Position date: 2020-05-14 words: 529 flesch: 32 summary: Polymerase chain reaction (PCR) testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was sent and came back positive after 48 hours. The patient was diagnosed with severe acute respiratory distress syndrome (ARDS), so was treated with inhaled pulmonary vasodilators, neuromuscular blockade and prone-position ventilation. keywords: acute; lung; patient cache: cord-274245-pgfqkwqg.txt plain text: cord-274245-pgfqkwqg.txt item: #1088 of 2876 id: cord-274250-95yzt1gj author: Mortaz, Esmaeil title: Silent hypoxia: higher NO in red blood cells of COVID-19 patients date: 2020-10-16 words: 2719 flesch: 42 summary: There is no evidence that direct oxygen therapy is beneficial in the management of breathlessness in severe COVID-19 patients but our data suggests that NO therapy may be beneficial in COVID-19 patients with hypoxia [23] . Whether higher levels of intracellular NO inside RBC of COVID-19 infected patients drive the unexpected silent hypoxia phenotype needs to be examined in future clinical studies using NO donors in hypoxemic COVID-19 patients. keywords: blood; covid-19; hypoxia; intracellular; levels; oxygen; patients; rbc cache: cord-274250-95yzt1gj.txt plain text: cord-274250-95yzt1gj.txt item: #1089 of 2876 id: cord-274282-hvx5m2bx author: Liu, Yang title: Association between ages and clinical characteristics and outcomes of coronavirus disease 2019 date: 2020-04-27 words: 1543 flesch: 45 summary: However, the ages related clinical characteristics, diseases courses and outcomes other than death in COVID-19 patients remain unclear. This is the first study to systematically evaluate the impact of age on the clinical characteristics and important outcomes for COVID-19 patients, thus helping clinicians to establish risk stratification of COVID-19 patients as early as possible. keywords: covid-19; disease; patients; study cache: cord-274282-hvx5m2bx.txt plain text: cord-274282-hvx5m2bx.txt item: #1090 of 2876 id: cord-274324-obhrbxu4 author: Tian, Wenjie title: Predictors of mortality in hospitalized COVID‐19 patients: A systematic review and meta‐analysis date: 2020-05-22 words: 3022 flesch: 42 summary: Accepted Article cerebrovascular disease, diabetes, chronic renal disease, smoking history, COPD) between COVID-19 patients who survived and those who did not survive. For laboratory data (i.e. continuous measures) we calculated weighted mean differences (WMD) and 95% confidence intervals (95% CI) in COVID-19 patients who survived versus those who did not survive whenever two or more studies reported a given parameter. keywords: analysis; covid-19; disease; meta; mortality; patients; risk; studies cache: cord-274324-obhrbxu4.txt plain text: cord-274324-obhrbxu4.txt item: #1091 of 2876 id: cord-274331-0i2opmcn author: Wang, Catherine J. title: COVID‐19 infection on IL‐23 inhibition date: 2020-07-14 words: 388 flesch: 42 summary: A database to collect information on COVID-19 patients on biologic therapy and their outcomes would be instrumental to guide clinicians on best practices for now and in future pandemics. However, more data needs to be obtained about biologics in COVID-19 patients, in particular whether or not biologic dosage timeline should be adjusted based on resolution of infection. keywords: covid-19; patient cache: cord-274331-0i2opmcn.txt plain text: cord-274331-0i2opmcn.txt item: #1092 of 2876 id: cord-274355-6hiutrct author: Satheesan, Manoj Kumar title: A numerical study of ventilation strategies for infection risk mitigation in general inpatient wards date: 2020-02-22 words: 4946 flesch: 45 summary: In the base case as shown in Fig. 1(a) , the supply air and ward air exhausted to the corridor were set to be equal for all air change rates. Furthermore, the randomness associated with particle deposition rates (r w , r c , and r f ) under different air change rate conditions can be attributed to the asymmetric airflow distribution patterns and locations of the infected patients. keywords: air; airflow; cubicle; et al; infection; particles; patients; study; ventilation; ward cache: cord-274355-6hiutrct.txt plain text: cord-274355-6hiutrct.txt item: #1093 of 2876 id: cord-274481-k1dp1ilv author: Falavigna, Maicon title: Guidelines for the pharmacological treatment of COVID-19. The task-force/consensus guideline of the Brazilian Association of Intensive Care Medicine, the Brazilian Society of Infectious Diseases and the Brazilian Society of Pulmonology and Tisiology date: 2020 words: 6979 flesch: 33 summary: COVID-19 Treatment Guidelines Zhejiang Da Xue Xue Bao Yi Xue Ban Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: openlabel, randomized, controlled trial Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19 Observational study of hydroxychloroquine in hospitalized patients with Covid-19 Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19) Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: a retrospective analysis of 1061 cases in Marseille, France A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19. Zhejiang Da Xue Xue Bao Yi Xue Ban Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open-label, randomized, controlled trial Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Risk of QT interval prolongation associated with use of hydroxychloroquine with or without concomitant azithromycin among hospitalized patients testing positive for coronavirus disease 2019 (COVID-19) Observational study of hydroxychloroquine in hospitalized patients with Covid-19 Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: a retrospective analysis of 1061 cases in Marseille, France Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection The QT interval in patients with SARS-CoV-2 infection treated with hydroxychloroquine/ azithromycin Early description of coronavirus 2019 disease in kidney transplant recipients in New York Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin. keywords: agents; azithromycin; coronavirus; covid-19; evidence; hydroxychloroquine; patients; recommendations; risk; studies; study; therapy; treatment; trials; use cache: cord-274481-k1dp1ilv.txt plain text: cord-274481-k1dp1ilv.txt item: #1094 of 2876 id: cord-274494-heu6rmbt author: Pablos, Jose L title: Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases date: 2020-06-12 words: 3124 flesch: 28 summary: These data provide a basis to improve preventive recommendations to rheumatic patients and to analyse the specific factors involved in COVID-19 susceptibility. These data provide a basis to improve preventive recommendations to rheumatic patients and to analyse the specific factors involved in coVid-19 susceptibility. keywords: covid-19; disease; hospital; patients; population; prevalence; reference cache: cord-274494-heu6rmbt.txt plain text: cord-274494-heu6rmbt.txt item: #1095 of 2876 id: cord-274542-fpzk5k79 author: Patti, Giuseppe title: Questions and Answers on Practical Thrombotic Issues in SARS-CoV-2 Infection: A Guidance Document from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology date: 2020-11-03 words: 5631 flesch: 26 summary: Bruxelles: European Society of Cardiology Efficacy of various treatment modalities for nCOV-2019: a systematic review and metaanalysis Swinging the pendulum: lessons learned from public discourse concerning hydroxychloroquine and COVID-19 Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Treatment with lopinavir/ ritonavir or interferon-β1b improves outcome of MERSCoV infection in a nonhuman primate model of common marmoset Treatment of Middle East respiratory syndrome with a combination of lopinavirritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Post-exposure prophylaxis for Middle East respiratory syndrome in healthcare workers A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Effectiveness of remdesivir for the treatment of hospitalized Covid-19 persons: a network meta-analysis Novel coronavirus treatment with ribavirin: groundwork for evaluation concerning COVID-19 Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19 Dexamethasone in hospitalized patients with Covid-19-preliminary report Tocilizumab treatment in COVID-19: a single center experience Antithrombotic treatments in patients with SARS-CoV-2 infection: from current evidence to reasonable recommendations-a position paper from the Italian Working Group on Atherosclerosis, Thrombosis and Vascular Biology Edoxaban for the treatment of cancer-associated venous thromboembolism Direct oral anticoagulant plasma levels' striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: the Cremona experience Hepatotoxicity of tocilizumab and anakinra in rheumatoid arthritis: management decisions COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? Pathophysiological basis and rationale for early outpatient treatment of SARS-CoV-2 (COVID-19) Infection Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID-19: initial assessment Current overview on hypercoagulability in COVID-19 COVID-19 and thrombotic or thromboembolic disease: Finally, general practitioners were not able to immediately assist patients on VKAs in need of INR adjustments, as they were also fully involved in the management of COVID-19 patients. keywords: cov-2; covid-19; infection; patients; risk; ritonavir; sars; score; therapy; treatment; use; vte cache: cord-274542-fpzk5k79.txt plain text: cord-274542-fpzk5k79.txt item: #1096 of 2876 id: cord-274556-531jlpwr author: Li, Wenrui title: Impact of COVID-19 on Peripheral Arterial Disease Treatment date: 2020-06-02 words: 253 flesch: 44 summary: With the conditions of PAD patients getting more serious when they come to the hospital, it is necessary to choose appropriate treatment to control perioperative complications and mortality. Finally, on the basis of controlling the covid-19 pandemic, daily medical activities should be resumed as soon as possible to provide reasonable treatment for more patients with PAD. keywords: patient cache: cord-274556-531jlpwr.txt plain text: cord-274556-531jlpwr.txt item: #1097 of 2876 id: cord-274557-2071770h author: Späth, Peter J. title: On the Dark Side of Therapies with Immunoglobulin Concentrates: The Adverse Events date: 2015-02-05 words: 10245 flesch: 27 summary: Epidemic hepatitis B caused by commercial human immunoglobulin Intravenous administration of human γ-globulin Adverse reactions following administration of human gamma-globulin IgG antibodies to IgA in two patients with hypogammaglobulinemia treated with commercial gammaglobulin Contact-activated factors: contaminants of immunoglobulin preparations with coagulant and vasoactive properties Fatal thrombotic events during treatment of autoimmune thrombocytopenia with intravenous immunoglobulin in elderly patients Effect of high-dose intravenous immunoglobulin therapy on blood rheology Pathogen safety of immunoglobulin preparations Population screening for variant Creutzfeldt-Jakob disease using a novel blood test: diagnostic accuracy and feasibility study Intravenous immunoglobulin: exploiting the potential of natural antibodies Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion The natural human IgG anti-F(ab')2 antibody recognizes a conformational IgG1 hinge epitope Stimulation of complement amplification by F(ab') 2 -containing immune complexes and naturally occurring anti-hinge antibodies -possible role in systemic inflammation Natural autoantibodies to Fcγ receptors in intravenous immunoglobulins Multi-faceted role of naturally occurring autoantibodies in fighting pathogens Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin Intravenous immunoglobulin: an update on the clinical use and mechanisms of action Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood Concurrent presence of agonistic and antagonistic anti-CD95 autoantibodies in intravenous Ig preparations A differential concentration-dependent effect of IVIg on neutrophil functions: Relevance for anti-microbial and anti-inflammatory mechanisms Verträglichkeit und Virussicherheit von intravenösen Immunglobulinen Occurrence of hemolytic reactions (HRS) on the same day as immune globulin (IG) product administrations during Cerebral venous and sinus thrombosis associated with subcutaneous immunoglobulin injection and oral contraceptive use Multiple immunoglobulin intolerance without antibody's anti-immunoglobulin A: a case report Common variable immunodeficiency: a patient with anaphylaxis to intravenous and subcutaneous immunoglobulin Prospective study on CVID patients with adverse reactions to intravenous or subcutaneous IgG administration Severe adverse reaction to subcutaneous immunoglobulin therapy in a patient with common variable immunodeficiency Evaluation of the relationship between injection site reaction rate and SCIg doses in patients with primary immunodeficiencies Immunthemotherapy: A Guide to Immunoglobulin Prophylaxis and Therapy Prophylactic infusions with an unmodified intravenous immunoglobullin product causing few side-effects in patients with antibody deficiency syndromes The role of anti-IgA antibodies in causing adverse reactions to gamma globulin infusion in immunodeficient patients: a comprehensive review of the literature Prevalence of immunoglobulin a deficiency (IgAD) in Shanghai blood donors and efforts to establish a rare blood bank of IgAD in Shanghai Hammarström L, Persson MAA, Smith CIE. The complement-mediated AEs were considered to be caused by aggregates in the product (spontaneous complement activation or anti-complementary activity or ACA) or by in vivo formation of immune complexes (ICs, patient's condition related; e.g., subclinical infections or the unnoticed presence of anti-IgA antibodies) and therefore only IgG concentrates with low or absent ACA is accepted by authorities for human use. keywords: aes; anti; antibodies; blood; complement; concentrates; dose; hemolysis; high; human; iga; igg; immune; immunoglobulin; infusion; intravenous; ivig; nabs; patients; therapy; thrombosis cache: cord-274557-2071770h.txt plain text: cord-274557-2071770h.txt item: #1098 of 2876 id: cord-274563-jimw6skv author: Fiumara, Agata title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 words: 3526 flesch: 45 summary: Although no statistically significant difference was found compared to controls, we felt that the reactions were qualitatively different, underlining the fragility and isolation of such patients. key: cord-274563-jimw6skv authors: Fiumara, Agata; Lanzafame, Giuseppina; Arena, Alessia; Sapuppo, Annamaria; Raudino, Federica; Praticò, Andrea; Pavone, Piero; Barone, Rita title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 journal: J Clin Med DOI: 10.3390/jcm9092716 sha: doc_id: 274563 cord_uid: jimw6skv Background: Lysosomal storage disorders (LSDs) are rare, chronic, progressive multisystem diseases implying severe medical issues and psychological burden. keywords: control; covid-19; disease; group; home; patients cache: cord-274563-jimw6skv.txt plain text: cord-274563-jimw6skv.txt item: #1099 of 2876 id: cord-274632-d9z0m2l8 author: Chenna, Avantika title: Coronavirus Disease 2019 (COVID-19) in a Renal Transplant Patient date: 2020-05-09 words: 1267 flesch: 42 summary: Transplant patients are particularly at a higher risk of contracting COVID-19 because of their immunosuppressed state, and they have the propensity to develop opportunistic infections. The pre-immunosuppressed state, along with other existing comorbidities, can influence the outcomes of COVID-19 in transplant patients. keywords: coronavirus; covid-19; patient; transplant cache: cord-274632-d9z0m2l8.txt plain text: cord-274632-d9z0m2l8.txt item: #1100 of 2876 id: cord-274666-0d8oz51l author: Han, Yi title: Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study date: 2020-06-24 words: 3810 flesch: 48 summary: Severe patients had higher APACHE II (8.5 vs. 4.0) and SOFA (2 vs. 1) scores on admission. The median age was 63 years (IQR, 49-71 years), and severe patients were significantly older than the non-severe ones (67 vs. 61, P = 0.005). keywords: cells; covid-19; ldh; patients; severity; study cache: cord-274666-0d8oz51l.txt plain text: cord-274666-0d8oz51l.txt item: #1101 of 2876 id: cord-274779-0emfl1e5 author: Andrews, Jinsy A. title: Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities date: 2020-06-05 words: 1836 flesch: 42 summary: 30 Surrogates for spirometry could also be explored for ALS patients. Results of a population-based study with longterm follow-up Incorporation of telehealth into a multi-disciplinary ALS clinic: feasibility and acceptability Excellent inter-rater, intra-rater, and telephone administered reliability of the ALSFRS-R in a multicenter trial Pulmonary function laboratories: advice regarding COVID-19 Association between decline in slow vital capacity and respiratory insufficiency, use of assisted ventilation, tracheostomy, or death in patients with amyotrophic lateral sclerosis Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology A multidisciplinary clinic approach improves survival in ALS: a comparative study of ALS in Ireland and Northern Ireland Therapeutic effects of percutaneous endoscopic gastrostomy on survival in patients with amyotrophic lateral sclerosis: A meta-analysis Multidisciplinary amyotrophic lateral sclerosis telemedicine care: the store and forward method Delivering tertiary centre specialty care to ALS patients via telemedicine: a retrospective cohort analysis Experience with telemedicine in a multi-disciplinary ALS clinic Interstate licensure for telemedicine: the time has come medicare-telemedicine-health-care-provider-fact-sheet The coronavirus disease 2019 crisis as a catalyst for telemedicine for chronic neurological disorders Computer and Internet Use in the United States Multidisciplinary ALS care improves quality of life in patient with ALS Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study The use of telehealth to enhance care in ALS and other neuromuscular disorders. keywords: als; care; pandemic; patients; research; telemedicine cache: cord-274779-0emfl1e5.txt plain text: cord-274779-0emfl1e5.txt item: #1102 of 2876 id: cord-274782-yymo9i6r author: Şahbat, Yavuz title: Management of orthopedic oncology patients during coronavirus pandemic date: 2020-07-02 words: 1935 flesch: 42 summary: We aimed to reduce both the healthcare workers' contact with patients and the patients' contact with other patients while coming to and from the hospital. We obtained data from the hospital information system regarding all oncologic orthopedics and trauma surgery patients operated on and followed between 11 March 2020, the date of the first confirmed case of coronavirus in Turkey, and 11 May 2020. keywords: covid-19; hospital; orthopedic; patients; surgery cache: cord-274782-yymo9i6r.txt plain text: cord-274782-yymo9i6r.txt item: #1103 of 2876 id: cord-274802-7ioiwsd8 author: Varghese, Praveen Mathews title: Host-pathogen interaction in COVID-19: Pathogenesis, potential therapeutics and vaccination strategies date: 2020-08-19 words: 19710 flesch: 31 summary: Unlike SARS, COVID-19 patients had the highest viral load near presentation, which could account for the fast-spreading nature of this epidemic. In a study involving COVID-19 patients in Hong Kong recorded high viral load on presentation with the onset of symptoms and also when the symptoms are mild (83) . keywords: activation; acute; antibodies; case; cells; china; complement; coronavirus; cov-2; covid-19; covid-19 patients; disease; dose; drug; high; human; infection; inflammation; injury; levels; novel; pathogenesis; patients; plasma; pneumonia; protein; response; sars; spike; studies; study; syndrome; system; transmission; treatment; trial; vaccine cache: cord-274802-7ioiwsd8.txt plain text: cord-274802-7ioiwsd8.txt item: #1104 of 2876 id: cord-274860-7ec2jcoq author: Salazar, Eric title: Significantly decreased mortality in a large cohort of COVID-19 patients transfused early with convalescent plasma containing high titer anti-SARS-CoV-2 spike protein IgG date: 2020-11-04 words: 4748 flesch: 40 summary: Retrospective analysis by the Ortho VITROS IgG assay revealed a median signal/cutoff (S/C) ratio of 24.0 for transfused units, a value far exceeding the recently FDA-required cutoff of 12.0 for designation of high titer convalescent plasma. With respect to altering mortality, our analysis identified an optimal window of 44 hours post-hospitalization for transfusing COVID-19 patients with high titer convalescent plasma. keywords: analysis; convalescent; covid-19; igg; mortality; patients; plasma; titer; transfusion cache: cord-274860-7ec2jcoq.txt plain text: cord-274860-7ec2jcoq.txt item: #1105 of 2876 id: cord-274871-jlquvz51 author: Nori, Priya title: Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge date: 2020-07-24 words: 2207 flesch: 37 summary: key: cord-274871-jlquvz51 authors: Nori, Priya; Cowman, Kelsie; Chen, Victor; Bartash, Rachel; Szymczak, Wendy; Madaline, Theresa; Punjabi Katiyar, Chitra; Jain, Ruchika; Aldrich, Margaret; Weston, Gregory; Gialanella, Philip; Corpuz, Marilou; Gendlina, Inessa; Guo, Yi title: Bacterial and fungal coinfections in COVID-19 patients hospitalized during the New York City pandemic surge date: 2020-07-24 journal: Infection control and hospital epidemiology DOI: 10.1017/ice.2020.368 sha: doc_id: 274871 cord_uid: jlquvz51 We observed bacterial or fungal coinfections in COVID-19 patients admitted between March 1 and April 18, 2020 (152 of 4,267, 3.6%). keywords: coinfections; covid-19; cultures; days; patients; study cache: cord-274871-jlquvz51.txt plain text: cord-274871-jlquvz51.txt item: #1106 of 2876 id: cord-274934-s8xppipe author: Gebbia, Vittorio title: Patients With Cancer and COVID-19: A WhatsApp Messenger-Based Survey of Patients’ Queries, Needs, Fears, and Actions Taken date: 2020-05-15 words: 3393 flesch: 40 summary: An R package for the extraction of sentiment and sentiment-based plot arcs from text Emotions evoked by common words and phrases: Using Mechanical Turk to create an emotion lexicon Managing cancer care during the COVID-19 pandemic: Agility and collaboration toward a common goal The blind leading the blind: COVID-19, cancer, and the need for more data COVID-19 and Cancer Consortium Patient engagement for metastatic breast cancer patients: WhatsApp counseling Assessing the feasibility and effectiveness of an app in improving knowledge on oral cancer-an interventional study WhatsApp in hospital? key: cord-274934-s8xppipe authors: Gebbia, Vittorio; Piazza, Dario; Valerio, Maria Rosaria; Borsellino, Nicolò; Firenze, Alberto title: Patients With Cancer and COVID-19: keywords: analysis; cancer; covid-19; data; oncologists; patients; queries; whatsapp cache: cord-274934-s8xppipe.txt plain text: cord-274934-s8xppipe.txt item: #1107 of 2876 id: cord-275004-qzg03dvg author: Veras, Flavio Protasio title: SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology date: 2020-09-14 words: 6397 flesch: 42 summary: Production of NETs by isolated neutrophils Neutrophils (10 6 cells) obtained from COVID-19 patients or healthy controls were incubated with RPMI 1640 supplemented with 0.1% BSA treated or not with Cl-Amidine (200 µM; Sigma-Aldrich; cat. 506282), tenofovir disoproxil fumarate (TDF; 10 µM; as described in Clososki et al., 2020) , neutralizing anti-ACE2 antibody (αACE2; 0.5 µg/ml; Rhea Biotech; cat. IM-0060), camostat mesylate (Camostat; 10 µM; Sigma-Aldrich; cat. SML0057). The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher levels of NETs. keywords: cells; controls; cov-2; covid-19; covid-19 patients; et al; fig; lung; nets; neutrophils; patients; release; sars cache: cord-275004-qzg03dvg.txt plain text: cord-275004-qzg03dvg.txt item: #1108 of 2876 id: cord-275041-fcdwitxy author: Ayerbe, Luis title: The association of treatment with hydroxychloroquine and hospital mortality in COVID-19 patients date: 2020-09-30 words: 3260 flesch: 46 summary: Using limited evidence and clinical experience, doctors have treated COVID-19 patients with different drugs to eliminate or reduce the presence of the virus, including hydroxychloroquine (HCQ) Once it was approved for clinical use in COVID-19 patients, HCQ was started immediately after admission, and it was stopped if any abnormalities were identified in the ECGs that were done on a daily basis to patients who were taking it. keywords: covid-19; hcq; hydroxychloroquine; mortality; patients; study cache: cord-275041-fcdwitxy.txt plain text: cord-275041-fcdwitxy.txt item: #1109 of 2876 id: cord-275110-safr9z37 author: Alexander, Paul Elias title: COVID-19 research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine date: 2020-04-21 words: 3338 flesch: 39 summary: key: cord-275110-safr9z37 authors: Alexander, Paul Elias; Debono, Victoria Borg; Mammen, Manoj J.; Iorio, Alfonso; Aryal, Komal; Deng, Dianna; Brocard, Eva; Alhazzani, Waleed title: COVID-19 research has overall low methodological quality thus far: case in point for chloroquine/hydroxychloroquine date: 2020-04-21 journal: J Clin Epidemiol DOI: 10.1016/j.jclinepi.2020.04.016 sha: doc_id: 275110 cord_uid: safr9z37 What is new? The overall body of COVID-19 research is very flawed methodologically. keywords: covid-19; hydroxychloroquine; patients; research; studies; treatment cache: cord-275110-safr9z37.txt plain text: cord-275110-safr9z37.txt item: #1110 of 2876 id: cord-275154-vwnpred5 author: Bermejo-Martin, Jesus F title: Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza date: 2009-12-11 words: 4654 flesch: 41 summary: Increase of IL-17 and TNF-α in hospitalized patients over control indicated that they also parallel severe disease, but the significantly higher levels of IL-17 and TNF-α in severe non critical patients compared to mild (difference not found for critical ones), could reflect a beneficial role of these cytokines in this particular subset of patients. Severe patients required hospitalization (n = 20), due to respiratory insufficiency (10 of them were admitted to the intensive care unit), while mild patients had exclusively flu-like symptoms (n = 15). keywords: cytokines; disease; hospitalized; infection; influenza; levels; mediators; nvh1n1; patients; responses; serum; virus cache: cord-275154-vwnpred5.txt plain text: cord-275154-vwnpred5.txt item: #1111 of 2876 id: cord-275185-9br8lwma author: Zeng, Hao title: The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series date: 2020-10-06 words: 6621 flesch: 46 summary: Herein, we performed a retrospective observational study involving eight critical or severe patients with COVID-19 from four designated hospitals in the southwest region of China, aiming to explore the potential efficacy and safety of CP therapy, and to provide more evidence for the quality control of donated plasma and reasonable clinical application of CP transfusion. As the patients have been treated by antiviral drugs and oxygen support before CP therapy, the body temperature, heart rate, and systolic pressure were normal even prior to CP transfusion, and kept unchanged within 5 days after CP transfusion as indicated in Table 4 . keywords: convalescent; cov-2; covid-19; days; igg; patients; plasma; sars; specific; therapy; transfusion; treatment cache: cord-275185-9br8lwma.txt plain text: cord-275185-9br8lwma.txt item: #1112 of 2876 id: cord-275214-mqvw0219 author: Burlacu, Alexandru title: Is Thrombophilic Genetic Profile Responsible for an Acute Ischemic Stroke in a COVID-19 Male Patient? date: 2020-10-15 words: 1022 flesch: 31 summary: COVID-19 associated coagulopathy and thrombotic complications Role of inherited thrombophilic profile on survival of patients with sepsis COVID19 coagulopathy in Caucasian patients ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank ACE I/D but not AGT (-6)A/G polymorphism is a risk factor for mortality in ARDS Unpuzzling COVID-19 prothrombotic state: are preexisting thrombophilic risk profiles responsible for heterogenous thrombotic events? We strongly suspect that subtle genetic risk factors for thrombotic events may influence the COVID-19 course, might hold the key to understanding the significant heterogeneity of COVID-19 manifestations, and may prove useful in assessing the COVID-19 patients' risk for thrombosis and severe disease. keywords: covid-19; factor; risk; thrombosis cache: cord-275214-mqvw0219.txt plain text: cord-275214-mqvw0219.txt item: #1113 of 2876 id: cord-275257-upj8mvzn author: Hwang, E. Shelley title: Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change date: 2020-06-14 words: 8502 flesch: 36 summary: key: cord-275257-upj8mvzn authors: Hwang, E. Shelley; Balch, Charles M.; Balch, Glen C.; Feldman, Sheldon M.; Golshan, Mehra; Grobmyer, Stephen R.; Libutti, Steven K.; Margenthaler, Julie A.; Sasidhar, Madhu; Turaga, Kiran K.; Wong, Sandra L.; McMasters, Kelly M.; Tanabe, Kenneth K. title: Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change date: 2020-06-14 journal: Ann Surg Oncol DOI: 10.1245/s10434-020-08673-6 sha: doc_id: 275257 cord_uid: upj8mvzn BACKGROUND: A summary of key measures that have established a framework from which to address these issues is provided, as well as additional strategies for managing resumption of surgical care in cancer patients. keywords: cancer; care; covid-19; covid-19 pandemic; guidelines; healthcare; hospitals; lung; pandemic; patients; risk; surgery; telemedicine; therapy; time; treatment; use; visits cache: cord-275257-upj8mvzn.txt plain text: cord-275257-upj8mvzn.txt item: #1114 of 2876 id: cord-275260-xuhxqkyj author: Sardu, Celestino title: Hyperglycaemia on admission to hospital and COVID-19 date: 2020-07-06 words: 1204 flesch: 39 summary: To investigate the importance of glucose management of COVID-19 patients, we analysed recent data on glycaemic control and COVID-19 outcomes. This interpretation of the data underestimates the importance of glycaemic control in COVID-19 and may result in caregivers focusing attention on therapeutic management of hyperglycaemic patients. keywords: covid-19; disease; glucose; patients cache: cord-275260-xuhxqkyj.txt plain text: cord-275260-xuhxqkyj.txt item: #1115 of 2876 id: cord-275266-e6omvo5x author: Kort, Nanne P title: Resuming hip and knee arthroplasty after COVID-19: ethical implications for well-being, safety and the economy date: 2020-07-07 words: 5311 flesch: 44 summary: Following general social distancing principles, reallocation of treatment of elective patients into a private sector might reduce the risk of SARS-CoV-2 infection of elective patients, because public hospitals or academic centres are more often confronted with COVID-19 patients. Hence, a shift from elective joint arthroplasty patients from public hospitals into private hospitals would further disrupt clinical science and researchers and research questions might not be able to have direct contact with patients. keywords: arthroplasty; care; covid-19; elective; hip; hospitals; knee; pandemic; patients; risk; surgery; total cache: cord-275266-e6omvo5x.txt plain text: cord-275266-e6omvo5x.txt item: #1116 of 2876 id: cord-275272-qdg8sqpy author: Soares-Júnior, José Maria title: Gynecology and women’s health care during the COVID-19 pandemic: Patient safety in surgery and prevention date: 2020-06-16 words: 2039 flesch: 34 summary: In this context, based on a recent publication regarding patient safety in elective surgeries (9) (10) (11) , as well as on the law of access to treatment and laws related to women's health care (23, 24) , we propose the inclusion of gynecological surgery cases, stratified as follows ( Figure 1 ): Emergency (o1h): Peritonitis by tubo-ovarian and/or pelvic abscess, necrotizing fasciitis in surgeries for pelvic and breast neoplasms; DOI: 10.6061/clinics/2020/e2063 Urgent (o24h): Postoperative infections, acute inflammatory abdomen (adnexal tortoise, myoma tortoise, ovarian cysts), hemorrhagic conditions (ovarian cysts); Elective urgent (o2 weeks): Surgeries for neoplasms of the lower genital tract and breast previously diagnosed by pathological examination; Essential Elective (42 to o3 months): Hysteroscopy for abnormal uterine bleeding (unknowledge causes, suspected malignancy, and menopausal transition), postmenopausal bleeding (suspected malignancy), cervical conization or looped electro excision procedure (to exclude neoplasm in the lower genital tract); Non-essential/elective surgery: Infertility procedures, family planning procedures (bilateral tubal ligation procedure). Patients should be evaluated for possible viral infection, and universal screening should be considered for all surgical candidates and patients undergoing surgical procedures. keywords: care; covid-19; elective; health; pandemic; procedures; surgeries cache: cord-275272-qdg8sqpy.txt plain text: cord-275272-qdg8sqpy.txt item: #1117 of 2876 id: cord-275340-q8d7rvnj author: Sun, JingKang title: Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 date: 2020-06-21 words: 6638 flesch: 44 summary: In a randomized clinical trial from Wuhan about HCQ treatment of mild COVID-19 [50] , 31 out of 62 patients received HCQ (200 mg/2 times/day for 5 days). In the initial trial from France, of the 84 patients receiving HCQ treatment, 8 patients discontinued HCQ owing to ECG modifications within 4 days. keywords: activity; azithromycin; coronavirus; cov-2; covid-19; group; hcq; patients; results; sars; studies; study; treatment cache: cord-275340-q8d7rvnj.txt plain text: cord-275340-q8d7rvnj.txt item: #1118 of 2876 id: cord-275349-b35pt3mo author: Lenz, Heinz-Josef title: The Emergence of Baricitinib: A Story of Tortoises Versus Hares date: 2020-07-06 words: 1406 flesch: 29 summary: Baricitinib treatment over prolonged periods in RA patients has been associated with increased infections and thromboembolism, but the short duration of treatment in COVID-19 patients may mitigate against such side effects. One would be advised to remain vigilant of such signals reflecting thromboembolic or infection risk in randomized controlled trials testing a variety of immunomodulatory therapies in COVID-19 patients, either alone or in combination, especially in view of associations between clots and SARS-CoV-2 infection [10] . keywords: baricitinib; covid-19; patients; treatment cache: cord-275349-b35pt3mo.txt plain text: cord-275349-b35pt3mo.txt item: #1119 of 2876 id: cord-275440-fl4dsu7d author: Turnidge, John title: Responsible Prescribing for Upper Respiratory Tract Infections date: 2012-10-10 words: 6474 flesch: 41 summary: A clinical scoring method to reduce unnecessary antibiotic use in patients with sore throat Pharyngitis -principles of judicious use of antimicrobial agents Acute otitis media: management and surveillance in an era of pneumococcal resistance -a report from the Drug-resistant Streptococcus pneumoniae Therapeutic Working Group Recurrent and persistent otitis media Antibiotic for acute otitis media in children (Cochrane review). Most favour the strategy of prescribing antibacterials only when certain criteria are fulfilled, delaying antibacterial prescribing for at least 24 hours. keywords: antibacterials; benefit; infection; media; otitis; patients; prescribing; throat; treatment; use cache: cord-275440-fl4dsu7d.txt plain text: cord-275440-fl4dsu7d.txt item: #1120 of 2876 id: cord-275477-blu6wjhu author: Trimaille, Antonin title: COVID-19 et pathologie thromboembolique veineuse date: 2020-09-29 words: 2416 flesch: 26 summary: Patients: Awareness of an Increased Prevalence Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Incidence of venous thromboembolism in hospitalized patients with COVID-19 Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Extremely High Incidence of Lower Extremity Deep Venous Thrombosis in 48 Patients With Severe COVID-19 in Wuhan Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography Pulmonary embolism in COVID-19 patients: a French multicentre cohort study High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Venous thromboembolism in critically Ill patients with COVID-19: Results of a screening study for deep vein thrombosis Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels Venous thromboembolism in non-critically ill patients with COVID-19 infection Deep Vein Thrombosis in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19) in Wuhan, China: Prevalence, Risk Factors, and Outcome Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors High prevalence of deep vein thrombosis in mechanically ventilated COVID-19 patients Incidence of deep vein thrombosis among non-ICU patients hospitalized for COVID-19 despite pharmacological thromboprophylaxis Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19) ETEV au cours de la COVID-19 aggrave le pronostic des patients (3, 4) . keywords: cours; covid-19; dans; des; etev; incidence; les; patients; une cache: cord-275477-blu6wjhu.txt plain text: cord-275477-blu6wjhu.txt item: #1121 of 2876 id: cord-275506-3t5gf66c author: Agbuduwe, Charles title: Hematolological Manifestations of COVID‐19: From Cytopenia to Coagulopathy date: 2020-07-14 words: 4288 flesch: 27 summary: [17] In addition to a significant reduction in both CD4+ and CD8+ T lymphocyte subsets in COVID-19 patients, severe cases had much lower CD8+ lymphocytes and a subsequent increase positively correlated with improved clinical outcomes. [14] Similar findings were reported in a French cohort study with mild thrombocytopenia identified in about a quarter of COVID-19 patients on admission to hospital and this was independently predictive of the risk of admission to ICU, mechanical ventilation or death. keywords: article; blood; cases; cov-2; covid-19; disease; patients; sars; study cache: cord-275506-3t5gf66c.txt plain text: cord-275506-3t5gf66c.txt item: #1122 of 2876 id: cord-275518-p03sl946 author: Borsa, Stefano title: Call of duty: neuro-oncology outpatient management during the COVID-19 pandemic in Milan, ITALY date: 2020-07-10 words: 754 flesch: 53 summary: During the outpatient activity, a policy was deployed to mitigate the risk of exposure of patients and further dissemination of COVID-19. Health-care providers and patients followed the hospital keywords: covid-19; patients cache: cord-275518-p03sl946.txt plain text: cord-275518-p03sl946.txt item: #1123 of 2876 id: cord-275742-7jxt6diq author: Batarseh, Feras A. title: Preventive healthcare policies in the US: solutions for disease management using Big Data Analytics date: 2020-06-23 words: 7227 flesch: 52 summary: Completeness of health data is required to allow for comprehensive examinations and to provide early recommendations to preventive parameters. NHANES data are cross-sectional (i.e. collected at a single point in time); thus a follow up on patients is required for ML trends and forecasts [16] . keywords: clustering; data; disease; healthcare; imputations; medical; methods; models; nhanes; patients; periodontitis; results; variables cache: cord-275742-7jxt6diq.txt plain text: cord-275742-7jxt6diq.txt item: #1124 of 2876 id: cord-275828-c6d6nk7x author: Mikasa, Keiichi title: JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG date: 2016-07-31 words: 39699 flesch: 37 summary: In the treatment of hospital-acquired pneumonia, the duration of antimicrobial therapy generally tends to be longer than required for the following reasons: opacity on chest X-ray often remains for reasons other than pneumonia even after the start of antimicrobial drug treatment; and there may be a large number of latent nonpneumonia (or non-infectious-disease) factors that may cause increase in body temperature or CRP level in inpatients (Table 5 GNR b ), the expression of intrinsic antimicrobial-drugresistance genes encoded in chromosome genes is induced during antimicrobial drug treatment, a phenomenon which is basically rarely seen in E. coli, Klebsiella spp., H. influenzae, and M. catarrhalis (Table 5 GNR a ) ( Table 5) keywords: administration; aspiration pneumonia; bacteria; cases; children; clinical; combination; community; day; days; diagnosis; disease; dose; drip; drug; drug therapy; guidelines; hospital; infection; japan; management; microorganisms; oral; patients; period; pneumonia; pulmonary; risk; severe; society; spp; study; susceptibility; symptoms; therapy; times; treatment; tuberculosis; type cache: cord-275828-c6d6nk7x.txt plain text: cord-275828-c6d6nk7x.txt item: #1125 of 2876 id: cord-275913-85u6v3ib author: Bauernschmitt, Robert title: Valve-in-valve transcatheter aortic valve replacement in a young patient with a suspected COVID-19 infection: a surgical dilemma in the era of the COVID-19 pandemic date: 2020-06-08 words: 1085 flesch: 36 summary: In the current COVID-19-pandemic, it is important to rule out an infection with COVID-19 in patients undergoing cardiac surgery to prevent complications from COVID-19 infection for a variety of reasons-for example, there is currently no available information on how these patients tolerate cardiopulmonary bypass. Recently, it has been discussed that PCR testing might be inferior to CT scans to detect infections as the average time between initial negative and positive reverse transcription polymerase chain reaction test results in patients who already display signs of infection on CT scans is 5.1 ± 1.5 days keywords: covid-19; infection; patient cache: cord-275913-85u6v3ib.txt plain text: cord-275913-85u6v3ib.txt item: #1126 of 2876 id: cord-275979-cx2h5bsw author: Scutelnic, Adrian title: Vascular Events, Vascular Disease and Vascular Risk Factors—Strongly Intertwined with COVID-19 date: 2020-10-08 words: 6757 flesch: 42 summary: At present, current guidelines do not recommend to prophylactically prescribe ACEIs/ARBs to decrease COVID-19 infection risk and to improve outcome of COVID-19, and they do not recommend to switch an established treatment for these antihypertensive drugs in COVID-19 patients Studies have found pathological laboratory test results in COVID-19 patients, especially in those with severe COVID-19, such as elevated leukocyte counts, reduced lymphocyte counts and elevated levels of C-reactive protein, Ddimer levels, ferritin and lactate dehydrogenase, indicating hypercoagulability Patient with ischaemic stroke because of large vessel occlusion. keywords: analysis; covid-19; diabetes; disease; factors; patients; risk; sars; stroke; study cache: cord-275979-cx2h5bsw.txt plain text: cord-275979-cx2h5bsw.txt item: #1127 of 2876 id: cord-276090-n8c2jpr6 author: Patel, Hiren N. title: Cerebellar Infarction Requiring Surgical Decompression in patient with COVID 19 Pathological Analysis, Brief Review date: 2020-07-29 words: 2875 flesch: 36 summary: Larger studies will be helpful to examine the impact of diabetes in COVID-19 patients as a risk factor for development of anti-phospholipid antibodies, coagulopathy and stroke. There are currently ten clinical trials underway worldwide as per clinicaltrials.gov that are looking at the efficacy of dexamethasone in COVID-19 patients. keywords: cov-2; covid-19; disease; patient; sars; stroke; thrombosis cache: cord-276090-n8c2jpr6.txt plain text: cord-276090-n8c2jpr6.txt item: #1128 of 2876 id: cord-276132-tv5y1eqc author: Ray, Upasana title: COVID-19: The Impact in Oncology Care date: 2020-10-23 words: 5705 flesch: 33 summary: The crisis stage deals with when the system over surpluses with the COVID-19 cases and deprived of its ability to provide cancer patient care. With the increasing risk of cancer patients acquiring infection during receiving the essential care, the debate ensues on how to balance the risk factors and benefits out of the oncologic emergencies in cancer patients. keywords: cancer; cancer patients; care; coronavirus; covid-19; disease; guidelines; health; infection; pandemic; patients; risk; treatment cache: cord-276132-tv5y1eqc.txt plain text: cord-276132-tv5y1eqc.txt item: #1129 of 2876 id: cord-276234-2nkeq4ud author: Siedlecki, Jakob title: COVID-19: Ophthalmological Aspects of the SARS-CoV 2 Global Pandemic date: 2020-05-06 words: 3707 flesch: 39 summary: Indeed, ophthalmologists seem to rank among the medical specialties with the highest risk for COVID-19 infection, probably due to close patient contact during examination, e.g., at the slit lamp In a recent survey of ophthalmology practitioners in the UK, 80 % of participants stated that they felt at high risk of COVID-19 transmission keywords: coronavirus; covid-19; disease; eye; ophthalmology; pandemic; patients; recommendations; sars; symptoms; transmission cache: cord-276234-2nkeq4ud.txt plain text: cord-276234-2nkeq4ud.txt item: #1130 of 2876 id: cord-276241-4g6pa7kz author: Yurttaş, Berna title: Characteristics and outcomes of Behçet’s syndrome patients with Coronavirus Disease 2019: a case series of 10 patients date: 2020-07-09 words: 1738 flesch: 51 summary: Mild or moderate Covid-19 Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Incidence of venous thromboembolism in hospitalized patients with COVID-19 Incidence of COVID-19 in a cohort of adult and paediatric patients with rheumatic diseases treated with targeted biologic and synthetic disease-modifying anti-rheumatic drugs SARS-CoV-2 infection among patients with systemic autoimmune diseases Behçet syndrome: a contemporary view Phenotypes in Behçet's syndrome Update on the treatment of Behçet's syndrome Sensitivity of chest CT for COVID-19: comparison to RT-PCR Clinical features of rheumatic patients infected with COVID-19 in Wuhan, China An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 Characteristics and outcomes of recipients of heart transplant with coronavirus disease 2019 Colchicine as a potent anti-inflammatory treatment in COVID-19: can we teach an old dog new tricks? Thromboembolic events may occur in hospitalized patients receiving thrombo-prophylaxis either in general ward conditions or in ICU [4] [5] [6] [7] . keywords: case; covid-19; disease; patients cache: cord-276241-4g6pa7kz.txt plain text: cord-276241-4g6pa7kz.txt item: #1131 of 2876 id: cord-276249-9opsg7p2 author: Roberto, Katrina T. title: Electroencephalographic findings in COVID-19 patients: A systematic review date: 2020-09-15 words: 3124 flesch: 35 summary: key: cord-276249-9opsg7p2 authors: Roberto, Katrina T.; Espiritu, Adrian I.; Fernandez, Marc Laurence L.; Gutierrez, Josephine C. title: Electroencephalographic findings in COVID-19 patients: A systematic review date: 2020-09-15 journal: Seizure DOI: 10.1016/j.seizure.2020.09.007 sha: doc_id: 276249 cord_uid: 9opsg7p2 BACKGROUND: Further research on the relationship of the EEG findings to the clinical state and short- or long-term prognosis of COVID-19 patients may be conducted to help clinicians discern which patients would necessitate an EEG procedure and would eventually require treatment. keywords: cases; covid-19; eeg; findings; patients; review; studies cache: cord-276249-9opsg7p2.txt plain text: cord-276249-9opsg7p2.txt item: #1132 of 2876 id: cord-276264-wgzh3f5m author: Navlakha, S. title: Projecting COVID-19 disease severity in cancer patients using purposefully-designed machine learning date: 2020-08-25 words: 4669 flesch: 48 summary: Using clinical variables only collected on or before a patient's COVID-19 positive date (time zero), we sought to classify patients into one of three possible future outcomes: Severe-early (the patient required high levels of oxygen support within 3 days of being tested positive for COVID-19), Severe-late (the patient required high levels of oxygen after 3 days), and Non-severe (the patient never required oxygen support). Critically, classification accuracy is highest when using a potpourri of clinical variables -- including patient demographics, pre-existing diagnoses, laboratory and radiological work, and underlying cancer type -- suggesting that COVID-19 in cancer patients comes with numerous, combinatorial risk factors. keywords: cancer; covid-19; medrxiv; model; patients; preprint; review; variables cache: cord-276264-wgzh3f5m.txt plain text: cord-276264-wgzh3f5m.txt item: #1133 of 2876 id: cord-276267-77903fld author: Al‐Ani, Aysha H. title: Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient date: 2020-05-26 words: 5501 flesch: 30 summary: The clinical impact of coronavirus infection in patients with hematologic malignancies and hematopoietic stem cell transplant recipients Risk factors for opportunistic infections in patients with inflammatory bowel disease Clinical assessment of risk factors for infection in inflammatory bowel disease patients Methods to avoid infections in patients with inflammatory bowel disease Increased incidence of systemic serious viral infections in patients with inflammatory bowel disease associates with active disease and use of thiopurines Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths Letter: Covid-19, and vitamin D Letter: Covid-19 and vitamin D-authors' reply Quantitative proteomic analysis reveals the deregulation of nicotinamide adenine dinucleotide metabolism and CD38 in inflammatory bowel disease Protection of 318 inflammatory bowel disease patients from the outbreak and rapid spread of COVID-19 infection in Wuhan Secure-IBD Database Public Data Update Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China CDC_AA_refVa l=https %3A%2F%2Fwww.cdc.gov%2F-cor onavi rus%2F201 9-ncov%2Fcli nical -crite ria Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines SARS: systematic review of treatment effects Corticosteroid therapy for critically Ill patients with middle east respiratory syndrome The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis Factors associated with psychosis among patients with severe acute respiratory syndrome: a case-control study Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Glucocorticoid-induced diabetes in severe acute respiratory syndrome: the impact of high dosage and duration of methylprednisolone therapy Relationship between glucocorticoid receptor and deficiency syndrome and the regulation of traditional Chinese medicine Increased risk of influenza and influenza-related complications among 140,480 patients with inflammatory bowel disease Increased risk of pneumonia among patients with inflammatory bowel disease Prevention of infection caused by immunosuppressive drugs in gastroenterology The historical role and contemporary use of corticosteroids in inflammatory bowel disease Budesonide for maintenance of remission in Crohn's disease Efficacy and safety of oral beclomethasone dipropionate in ulcerative colitis: a systematic review and meta-analysis Oral prolonged release beclomethasone dipropionate and prednisone in the treatment of active ulcerative colitis: results from a double-blind, randomized, parallel group study Comparative safety of systemic and low-bioavailability steroids in inflammatory bowel disease: Systematic review and network meta-analysis Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus Risk of infection with methotrexate therapy in inflammatory diseases: a systematic review and meta-analysis Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT registry Risk for overall infection with anti-TNF and anti-integrin agents used in IBD: a systematic review and meta-analysis Comparative risk of serious infections with biologic and/or immunosuppressive therapy in patients with inflammatory bowel diseases: a systematic review and meta-analysis Anti-TNF-alpha therapy for patients with sepsis: a systematic meta-analysis Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection Ustekinumab as induction and maintenance therapy for Crohn's disease Risk of serious infection with biologic and systemic treatment of psoriasis: results from the psoriasis longitudinal assessment and registry IM-UNITI: three-year efficacy, safety, and immunogenicity of ustekinumab treatment of Crohn's disease Systematic review: the safety of vedolizumab for the treatment of inflammatory bowel disease Safety profile of biologic drugs in the therapy of Crohn disease: a systematic review and network meta-analysis Safety profile of biologic drugs in the therapy of ulcerative colitis: a systematic review and network meta-analysis The safety of vedolizumab for ulcerative colitis and Crohn's disease Differential expression of adhesion molecules and chemokines between nasal and small intestinal mucosae: implications for T-and sIgA+ B-lymphocyte recruitment Switch to adalimumab in patients with Crohn's disease controlled by maintenance infliximab: prospective randomised SWITCH trial Herpes zoster infection in patients with ulcerative colitis receiving tofacitinib Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study Tofacitinib as induction and maintenance therapy for ulcerative colitis Growing evidence of the safety of JAK inhibitors in patients with rheumatoid arthritis Real-world experience with tofacitinib in IBD at a Tertiary Center COVID-19: combining antiviral and anti-inflammatory treatments Guidance for discharge and ending isolation in the context of widespread community transmission of COVID-19 -first update Infection-related hospitalizations are associated with increased mortality in patients with inflammatory bowel diseases Nonpharmaceutical measures for pandemic influenza in nonhealthcare settings-social distancing measures Effectiveness of workplace social distancing measures in reducing influenza transmission: a systematic review Virtually perfect? In China healthcare workers made up 3.5% of COVID-19 patients and Italy have reported that 20% of its responding healthcare work force is being infected. keywords: bowel; clinical; coronavirus; cov-2; covid-19; disease; ibd; infection; patients; review; risk; sars; transmission; treatment cache: cord-276267-77903fld.txt plain text: cord-276267-77903fld.txt item: #1134 of 2876 id: cord-276288-upv2o8f6 author: Prior, Sarah Jane title: Person-centred data collection methods to embed the authentic voice of people who experience health challenges date: 2020-07-21 words: 3682 flesch: 36 summary: Clarification, adequacy and responsiveness in semistructured telephone and face-to-face interviews Computer-Mediated communication to facilitate synchronous online focus group discussions: feasibility study for qualitative HIV research among transgender women across the United States Interviewing to develop patient-reported outcome (pro) measures for clinical research: eliciting patients' experience Defining 'quality' from the patient's perspective: findings from focus groups with Medicaid beneficiaries and implications for public reporting Comparing focus groups and individual interviews: findings from a randomized study Focus groups as social arenas for the negotiation of normativity The impact of status and social context on health service co-design: an example from a collaborative improvement initiative in UK primary care Methodological aspects of focus groups in health research: results of qualitative interviews with focus group Moderators Online focus group discussions: an attractive approach to data collection for qualitative health research Citizens' jury: exploring opinions on treatment options for incontinence and research priorities The use of citizens' juries in health policy decision-making: a systematic review Do consumer voices in healthcare citizens' juries matter? From passive subject to active agent: the potential of citizens' juries for nursing research Citizens' juries and deliberative democracy Grounded citizens' juries: a tool for health activism? Talking about pictures: a case for photo elicitation Photo elicitation interview (PEI): using photos to elicit children's perspectives Auto-driven photo elicitation interviews in research with children: ethical and practical considerations Dear critics: addressing concerns and justifying the benefits of photography as a research method National safety and quality health service standards user guide for measuring and evaluating partnering with consumers Blending Video-Reflexive ethnography with Solution-Focused approach: a Strengths-Based approach to practice improvement in health care Anonymisation and visual images: issues of respect, 'voice' and protection Visualising health care practice improvement Creating spaces in intensive care for safe communication: a video-reflexive ethnographic study Researching reflexively with patients and families: two studies using video-reflexive ethnography to collaborate with patients and families in patient safety research Involving patients in understanding hospital infection control using visual methods Patient and public involvement in chronic illness: beyond the expert patient In healthcare, expert witnesses may include clinicians, policy-makers and health consumers who provide testimony about their personal experience of the aspect of healthcare under deliberation. keywords: focus; groups; health; healthcare; methods; participants; patient; quality; research cache: cord-276288-upv2o8f6.txt plain text: cord-276288-upv2o8f6.txt item: #1135 of 2876 id: cord-276303-lgywz9ea author: Rello, Jordi title: COVID-19, steroids and other immunomodulators: The jigsaw is not complete date: 2020-10-25 words: 1633 flesch: 34 summary: The Cochrane Database of Systematic Reviews Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. In severe CAP, corticosteroids use has resurfaced owing specifically to a large recent RCT (6), which found less treatment failure when methylprednisolone was used as an adjunctive therapy in patients with severe CAP and high inflammatory response. keywords: covid-19; days; mortality; patients; trial cache: cord-276303-lgywz9ea.txt plain text: cord-276303-lgywz9ea.txt item: #1136 of 2876 id: cord-276327-wyevh4xv author: Sheng, Calvin C title: Canakinumab to reduce deterioration of cardiac and respiratory function in SARS‐CoV‐2 associated myocardial injury with heightened inflammation (canakinumab in Covid‐19 cardiac injury: The three C study) date: 2020-08-24 words: 3243 flesch: 27 summary: Coronavirus disease 2019 (COVID-19): situation report Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy Clinical characteristics of Covid-19 in New York city Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 Compassionate use of remdesivir for patients with severe Covid-19 Remdesivir for the treatment of Covid-19 -preliminary report Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and lifethreatening COVID-19: a randomized clinical trial Dexamethasone in hospitalized patients with Covid-19 -preliminary report COVID-19 and the cardiovascular system Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Community-Acquired Pneumonia-China Network. Association between cardiac injury and mortality in hospitalized patients infected with avian influenza a (H7N9) virus Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan China Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Prognostic value of NT-proBNP in patients with severe COVID-19 Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) COVID-19: consider cytokine storm syndromes and immunosuppression. keywords: canakinumab; cardiac; clinical; covid-19; inflammation; injury; patients; study; trial cache: cord-276327-wyevh4xv.txt plain text: cord-276327-wyevh4xv.txt item: #1137 of 2876 id: cord-276343-sb3vd7fq author: Humar, Atul title: Assessment of Adenovirus Infection in Adult Lung Transplant Recipients Using Molecular Surveillance date: 2006-12-31 words: 3532 flesch: 41 summary: Therefore, transplant patients may be at risk of adenovirus infection either from new acquisition or from re-activation of latent virus. sb3vd7fq Background Little is known about adenovirus infections in adult lung transplant recipients. keywords: adenovirus; infection; lung; patients; recipients; transplant; viremia cache: cord-276343-sb3vd7fq.txt plain text: cord-276343-sb3vd7fq.txt item: #1138 of 2876 id: cord-276359-syr9av09 author: Piva, Simone title: Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy date: 2020-04-14 words: 3316 flesch: 47 summary: CONCLUSIONS: ICU patients with COVID-19 frequently have hypertension. This is the first reported cohort of ICU patients with COVID-19 from the Lombardy region. keywords: covid-19; icu; non; patients; physicians; scale; therapies; ventilation cache: cord-276359-syr9av09.txt plain text: cord-276359-syr9av09.txt item: #1139 of 2876 id: cord-276405-yfvu83r9 author: Brat, Gabriel A. title: International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium date: 2020-08-19 words: 5733 flesch: 43 summary: RESTful API The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system Scalable collaborative infrastructure for a learning healthcare system (SCILHS): architecture SHRINE: enabling nationally scalable multi-site disease studies Overview of data collection and analysis The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories Accrual to Clinical Trials (ACT): a clinical and translational science award consortium network A translational engine at the national scale: informatics for integrating biology and the bedside Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy An interactive web-based dashboard to track COVID-19 in real time Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal Laboratory abnormalities in patients with COVID-2019 infection Impact of selective mapping strategies on automated laboratory result notification to public health authorities Learning from the crowd in terminology mapping: the LOINC experience Standardizing laboratory data by mapping to LOINC Evaluating congruence between laboratory LOINC value sets for quality measures, public health reporting, and mapping common tests Early vision for the CTSA Program Trial Innovation Network: a perspective from the National Center for Advancing Translational Sciences Launching PCORnet, a national patient-centered clinical research network German medical informatics initiative The COVID-19 Global Rheumatology Alliance: collecting data in a pandemic Recent developments in clinical terminologies-SNOMED CT, LOINC, and RxNorm i2b2: Informatics for Integrating Biology & the Bedside CTSA ACT Network i2b2 and SHRINE Ontology with 1-1 SHRINE Adapter Mapping File (Github The Unified Medical Language System (UMLS): integrating biomedical terminology All authors approved the manuscript. Aggregate laboratory data have limited ability to identify general trends in the admitted population. keywords: countries; covid-19; data; day; diagnosis; disease; hospitals; laboratory; level; number; patients; sites; tests; time; values cache: cord-276405-yfvu83r9.txt plain text: cord-276405-yfvu83r9.txt item: #1140 of 2876 id: cord-276438-nynri6my author: Lu, Jiade J. title: Experience of a Radiation Oncology Center Operating During the COVID-19 Outbreak date: 2020-04-10 words: 1545 flesch: 44 summary: Anyone with a body temperature over 37.3 o C and pertinent contact/travel history is transferred to a fever clinic at a designated hospital (special clinics of major general hospitals established during the 2003 SARS epidemic to triage and treat patients with fever) to rule out COVID-19 infection. Cancer treatment under such circumstances is tremendously challenging because patients undergoing radiation or chemotherapy may be more susceptible to infection, especially because cancer treatments usually require extended and continuous courses. keywords: cancer; covid-19; hospital; patients cache: cord-276438-nynri6my.txt plain text: cord-276438-nynri6my.txt item: #1141 of 2876 id: cord-276495-q22jnkn2 author: Belizário, José Ernesto title: Trained innate immunity, COVID-19 therapeutic dilemma, and fake science date: 2020-07-06 words: 2771 flesch: 37 summary: The objective is to demonstrate whether immunization with BCG vaccines produced using different strains and titers of the bacillus Calmette-Guérin-the vaccine against tuberculosis-can protect these professionals against SARS-CoV-2 infection (3). Clinical trials BRACE (www.clinicaltrialgov, number NCT04327206) and BCG-corona (www.clinicaltrial.gov, number NCT04328 441) are employing large cohorts of health professionals in the Netherlands, Denmark, Germany, England, France, Tanzania, Uganda, Colombia, and Uruguay (3). keywords: bcg; cells; chloroquine; covid-19; memory; patients; treatment; vaccine cache: cord-276495-q22jnkn2.txt plain text: cord-276495-q22jnkn2.txt item: #1142 of 2876 id: cord-276524-th6eu11h author: Atallah, Bassam title: Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers date: 2020-09-09 words: 2636 flesch: 38 summary: key: cord-276524-th6eu11h authors: Atallah, Bassam; El Nekidy, Wasim; Mallah, Saad I.; Cherfan, Antoine; AbdelWareth, Laila; Mallat, Jihad; Hamed, Fadi title: Thrombotic events following tocilizumab therapy in critically ill COVID-19 patients: a Façade for prognostic markers date: 2020-09-09 journal: Thromb J DOI: 10.1186/s12959-020-00236-9 sha: doc_id: 276524 cord_uid: th6eu11h BACKGROUND: Hospitals in the Middle East Gulf region have experienced an influx of COVID-19 patients to their medical wards and intensive care units. Our quaternary care hospital has adapted to accommodate the influx by approximately doubling ICU bed capacity, and dedicating half of it for COVID-19 patients. keywords: admission; covid-19; day; heparin; markers; patient; tocilizumab cache: cord-276524-th6eu11h.txt plain text: cord-276524-th6eu11h.txt item: #1143 of 2876 id: cord-276592-dsilwfl1 author: Chou, Calvin L title: How COVID-19 Disrupts—and Enhances—My Clinical Work date: 2020-04-08 words: 1382 flesch: 54 summary: key: cord-276592-dsilwfl1 authors: Chou, Calvin L title: How COVID-19 Disrupts—and Enhances—My Clinical Work date: 2020-04-08 journal: J Patient Exp DOI: 10.1177/2374373520918739 sha: doc_id: 276592 cord_uid: dsilwfl1 nan Sitting in my office right before the start of my primary care clinic, I studied my list of patients for the day. The rapid change in how I interact with patients in this era of the COVID-19 pandemic feels dizzying. keywords: communication; covid-19; medical; patients cache: cord-276592-dsilwfl1.txt plain text: cord-276592-dsilwfl1.txt item: #1144 of 2876 id: cord-276621-9exp8e7h author: Jacobs, Jeremy M. title: Prolonged Mechanical Ventilation: Symptomatology, Well-Being, and Attitudes to Life date: 2020-09-06 words: 4441 flesch: 40 summary: The positive perspective on overall health and well-being has also been noted in several studies of home PMV patients, 22 and although it may reflect high quality of care, it highlights the dissonance between good subjective patient-reported outcomes, on the one hand, and their extremely complex medical needs, functional impairment, and high technological dependence, on the other. Planned ventilation was more common among participants at home hospital, and the initiation of ventilation (prior to intubation) was discussed with the patient or family members and/or custodians among 74% vs 43% (P ¼ .001) of home vs LTAC PMV patients, respectively. keywords: care; home; participants; patients; pmv; score; study; ventilation cache: cord-276621-9exp8e7h.txt plain text: cord-276621-9exp8e7h.txt item: #1145 of 2876 id: cord-276635-0ciy732e author: Nijjer, Sukhjinder Singh title: Optimal management of acute coronary syndromes in the era of COVID-19 date: 2020-09-02 words: 4489 flesch: 44 summary: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Cardiovascular implications of fatal outcomes of patients with coronavirus disease Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: a metaanalysis Fourth universal definition of myocardial infarction Comparison of hospitalized patients with ARDS caused by COVID-19 and H1N1 Potential effects of coronaviruses on the cardiovascular system: a review SARS-CoV2: should inhibitors of the renin-angiotensin system be withdrawn in patients with COVID-19? Renin-Angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation Long-Term outcome of a routine versus selective invasive strategy in patients with non-ST-segment elevation acute coronary syndrome a meta-analysis of individual patient data Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19 Rivaroxaban in patients with a recent acute coronary syndrome ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of cardiology (ESC) An extended statement by the British cardiovascular intervention Society president regarding the COVID-19 pandemic EAPCI position statement on invasive management of acute coronary syndromes during the COVID-19 pandemic High thrombus burden in patients with COVID-19 presenting with ST-elevation myocardial infarction ST-Segment Elevation in Patients with Covid-19 -A Case Series Reperfusion of STEMI in the COVID-19 Era -Business as Usual? ► Patients with higher risk NSTEMI (dynamic ECG changes and elevated troponin) are best treated with revascularisation where possible. keywords: cardiac; care; covid-19; elevation; infarction; pandemic; patients; risk; stemi cache: cord-276635-0ciy732e.txt plain text: cord-276635-0ciy732e.txt item: #1146 of 2876 id: cord-276641-40r4mitg author: Elkhouly, Enas A title: Should cancer treatment be continued during the COVID-19 pandemic? A single Egyptian institution experience date: 2020-07-23 words: 3115 flesch: 55 summary: The aim of this article is based on the fact that the potential threat of COVID-19 to immunocompromised cancer patients as a result of their disease or the treatment delivered is thought to be significant, so it is of great importance to study the best measures to be used by oncology centres to prevent or limit the exposure of cancer patients to COVID-19 and to provide cancer treatment to patients in need, as safely and as correctly as possible. Cancer patients have weaker immune systems compared to the general population, both due to the disease itself and the treatment. keywords: cancer; covid-19; health; mcod; pandemic; patients; treatment; visits cache: cord-276641-40r4mitg.txt plain text: cord-276641-40r4mitg.txt item: #1147 of 2876 id: cord-276676-lgt0rzob author: Moka, Eleni title: Best Practice in Cardiac Anesthesia during the COVID-19 Pandemic: Practical Recommendations date: 2020-07-03 words: 5885 flesch: 31 summary: Strict measures and precautions for infection control should be implanted and must definitely be applied in the case of suspected/ confirmed COVID-19 cardiac surgery patients Cardiac surgery patients must always wear a N95/surgical mask, and at all times, and should be transported to the OR through a predesigned pathway. keywords: anesthesia; blood; cardiac; care; cases; coronavirus; covid-19; disease; equipment; health; infection; operations; pandemic; patients; surgery cache: cord-276676-lgt0rzob.txt plain text: cord-276676-lgt0rzob.txt item: #1148 of 2876 id: cord-276758-k2imddzr author: Siegel, Jane D. title: 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings date: 2007-12-07 words: 46244 flesch: 27 summary: Infection transmission risks are present in all hospital settings. 480, 481 Opportunites exist to conduct research in home care related to infection transmission risks. keywords: acute; agents; air; aureus; blood; care facilities; care settings; care unit; care workers; contact; contact precautions; contamination; control practices; disease; environmental; epidemiology; equipment; exposure; facility; factors; gloves; hand; hcws; health care; home care; hospital; hygiene; infection control; infection transmission; infections; influenza; isolation; measures; methicillin; nursing; outbreak; pathogens; patient care; patient transmission; patients; person; person transmission; practices; precautions; prevention; procedures; protection; recommendations; risk; room; safety; sars; standard; staphylococcus; studies; study; surveillance; term care; transmission; tuberculosis; use; vancomycin; virus cache: cord-276758-k2imddzr.txt plain text: cord-276758-k2imddzr.txt item: #1149 of 2876 id: cord-276782-3fpmatkb author: Garbey, M. title: A Model of Workflow in the Hospital During a Pandemic to Assist Management date: 2020-05-02 words: 5720 flesch: 56 summary: The hospital system needs to recruit resources quickly 349 enough to deliver quality patient care while keeping the staff safe from infection. On the hospital workflow side, while there is a large amount of work on this 27 topic [23] , one of the difficulties is to asses the death rate of patients hospitalized at the 28 beginning of the pandemic because the Length of stay (LOS) is rather long and the 29 disease is still not well understood [2, 16, 26] . keywords: care; hospital; license; model; number; patients; preprint; unit cache: cord-276782-3fpmatkb.txt plain text: cord-276782-3fpmatkb.txt item: #1150 of 2876 id: cord-276784-8lmg97zc author: Boziki, Marina Kleopatra title: COVID-19 Immunopathology and the Central Nervous System: Implication for Multiple Sclerosis and Other Autoimmune Diseases with Associated Demyelination date: 2020-06-04 words: 4784 flesch: 24 summary: Tocilizumab as a Potential Therapy Against COVID-19 Tocilizumab for the management of immune mediated adverse events secondary to PD-1 blockade Multiple sclerosis and the risk of infection: Considerations in the threat of the novel coronavirus, COVID-19/SARS-CoV-2 Neuroinvasion by human respiratory coronaviruses Epidemiologic evidence for multiple sclerosis as an infection An Italian programme for COVID-19 infection in multiple sclerosis Viruses and endogenous retroviruses in multiple sclerosis: Although most of COVID-19 patients exhibit normal leukocyte count, leucopenia keywords: coronavirus; cov-2; covid-19; disease; immune; infection; patients; potential; sars; system cache: cord-276784-8lmg97zc.txt plain text: cord-276784-8lmg97zc.txt item: #1151 of 2876 id: cord-276834-20lcihf4 author: Idilman, Ilkay S. title: Lung and kidney perfusion deficits diagnosed by dual-energy computed tomography in patients with COVID-19-related systemic microangiopathy date: 2020-08-29 words: 4517 flesch: 43 summary: KEY POINTS: • Pulmonary perfusion abnormalities in COVID-19 patients, associated with disease severity, can be detected by pulmonary DECT. However, these findings are based on recent pathological studies and it is evident that noninvasive diagnosis of the microvascular obstruction would be beneficial in the management of COVID-19 patients using early thromboprophylaxis. keywords: covid-19; dect; images; iodine; kidney; lung; patients; pds; perfusion; pulmonary cache: cord-276834-20lcihf4.txt plain text: cord-276834-20lcihf4.txt item: #1152 of 2876 id: cord-276856-88d3vzbs author: Petersen, Lonnie G. title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date: 2020-06-18 words: 646 flesch: 42 summary: One-way valves on both inspiratory and expiratory limbs ensured unidirectional flow, which both reduces functional dead space and the risk of crosscontamination between patient A and B, and seemingly also facilitated stable ventilation of B as A deteriorated. key: cord-276856-88d3vzbs authors: Petersen, Lonnie G.; Friend, James; Merritt, Sidney title: Single ventilator for multiple patients during COVID19 surge: matching and balancing patients date: 2020-06-18 journal: Crit Care DOI: 10.1186/s13054-020-03041-y sha: doc_id: 276856 cord_uid: 88d3vzbs nan With a potential COVID19-induced ventilator shortage, supporting multiple patients on a single ventilator seems a simple solution to maximize resources. keywords: cmh; patients; ventilator cache: cord-276856-88d3vzbs.txt plain text: cord-276856-88d3vzbs.txt item: #1153 of 2876 id: cord-276927-rxudwp2v author: Barbas, Carmen Sílvia Valente title: Goal-Oriented Respiratory Management for Critically Ill Patients with Acute Respiratory Distress Syndrome date: 2012-08-23 words: 8003 flesch: 26 summary: Revaluation of ARDS patients on the third day of evolution (Sequential Organ Failure Assessment (SOFA), biomarkers and response to infection therapy) allows changes in the initial treatment plans and can help decrease ARDS mortality. Fibrosis can be evident histologically as early as one week after the onset of ARDS and procollagen III peptide, a precursor of collagen synthesis, can be elevated in bronchoalveolar lavage fluid of ARDS patients at the time of tracheal intubation, its increment being associated with a poor ARDS prognosis. keywords: acute; ards; distress; injury; lung; mortality; oxygenation; patients; peep; pressure; pulmonary; risk; study; syndrome; ventilation; ventilatory cache: cord-276927-rxudwp2v.txt plain text: cord-276927-rxudwp2v.txt item: #1154 of 2876 id: cord-277014-iz8jo44e author: Hu, Weihua title: Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study date: 2020-10-16 words: 3650 flesch: 39 summary: In addition, hyponatremia patients required extensive treatment with oxygen, antibiotics, and corticosteroids. In addition, hyponatremia patients required intensive oxygen treatment compared to normonatremia patients (87.1 vs 60.1%) including the use of oxygen inhalation, oxygen absorption by mask, high-influx oxygen absorption, and non-invasive and invasive ventilation ( Table 3 ). keywords: clinical; covid-19; hyponatremia; normonatremia; patients; sodium; study; table; total cache: cord-277014-iz8jo44e.txt plain text: cord-277014-iz8jo44e.txt item: #1155 of 2876 id: cord-277096-zvb7n9wo author: Bond, David A. title: Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date: 2018-11-29 words: 3712 flesch: 35 summary: The need for routine bleomycin test dosing in the 21st century Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study Chimeric antigen receptormodified T cells in chronic lymphoid leukemia Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab Chimeric antigen receptor-modified T cells for acute lymphoid leukemia Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin's lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial Adapted treatment guided by interim PET-CT scan in advanced Hodgkin's lymphoma Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome Expression of the interferoninducible chemokine IP-10 (CXCL10), a chemokine with proposed antineoplastic functions, in Hodgkin lymphoma and nasopharyngeal carcinoma Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates up-regulation of CCL20 and the migration of regulatory T cells Epstein-Barr virus infection induces an increase of T regulatory type 1 cells in Hodgkin lymphoma patients Managing cytokine release syndrome associated with novel T cell-engaging therapies Febrile Hypotensive Reactions Following ABVD e128 -Clinical Lymphoma, Myeloma & Leukemia The febrile, hypotensive syndrome following bleomycin treatment is clinically similar to CRS, a syndrome in which macrophage activating cytokines IL-10 and IL-6 are elevated, and macrophage activation appears to be central to pathogenesis. keywords: abvd; bleomycin; chl; disease; hodgkin; lymphoma; patients; stage; treatment cache: cord-277096-zvb7n9wo.txt plain text: cord-277096-zvb7n9wo.txt item: #1156 of 2876 id: cord-277146-4a4vz36h author: Aggarwal, Mukul title: Hemostatic Abnormalities in COVID-19: An Update date: 2020-08-11 words: 4633 flesch: 37 summary: Lupus anticoagulant is frequent in patients with Covid-19 High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Arterial thromboembolic complications in COVID-19 in low risk patients despite prophylaxis Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Direct oral anticoagulant plasma levels' striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: the Cremona experience Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): a case series Therapeutic effects of dipyridamole on COVID-19 patients with coagulation dysfunction Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 COVID-19: towards understanding of pathogenesis Clinical features of patients infected with 2019 novel coronavirus in Wuhan COVID-19: consider cytokine storm syndromes and immunosuppression Cytokine storm and sepsis disease pathogenesis The coagulopathy of acute sepsis Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical characteristics of coronavirus disease 2019 in China Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases Pathological findings of COVID-19 associated with acute respiratory distress syndrome Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study Vander Heide RS (2020) Pulmonary and cardiac pathology in Covid-19: the first autopsy series from New Orleans The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease Thrombocytopenia and its association with mortality in patients with COVID-19 Association between platelet parameters and mortality in coronavirus disease 2019: retrospective cohort study Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 PROTECT collaborators, the Canadian Critical Care Trials Group, and the Australian, and New Zealand Intensive Care Society Clinical Trials Group (2013) Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes Mechanism of thrombocytopenia in COVID-19 patients COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure Incidence of venous thromboembolism in hospitalised patients with COVID-19 Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19 Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia D-dimer is associated with severity of coronavirus disease 2019: a pooled analysis The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Hypercoagulability of COVID-19 patients in intensive care unit a report of thromboelastography findings and other parameters of hemostasis Prominent changes in blood coagulation of patients with SARS-CoV-2 infection Coagulopathy and antiphospholipid antibodies in patients with Covid-19 International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) keywords: coagulation; coagulopathy; covid-19; dimer; disease; mortality; patients; pulmonary; risk; thromboprophylaxis; thrombosis cache: cord-277146-4a4vz36h.txt plain text: cord-277146-4a4vz36h.txt item: #1157 of 2876 id: cord-277148-xzpuc22p author: Ammirati, Enrico title: UPDATE ON ACUTE MYOCARDITIS date: 2020-06-01 words: 5857 flesch: 31 summary: European journal of heart failure Mode-of-action of the PROPELLA concept in fulminant myocarditis First successful bridge to recovery with the Impella Recover 100 left ventricular assist device for fulminant acute myocarditis Comparative outcomes in cardiogenic shock patients managed with Impella microaxial pump or extracorporeal life support. The last prerequisite is of particular concern in FM patients, as they often present with a relatively small LV cavity and thickened walls due to myocardial edema and the recent onset of myocardial damage. keywords: acute; cardiac; diagnosis; emb; fulminant; heart; myocarditis; patients; risk; shock; treatment cache: cord-277148-xzpuc22p.txt plain text: cord-277148-xzpuc22p.txt item: #1158 of 2876 id: cord-277178-nbotxv35 author: Vindrola-Padros, C. title: Remote home monitoring (virtual wards) during the COVID-19 pandemic: a living systematic review date: 2020-10-09 words: 5045 flesch: 43 summary: key: cord-277178-nbotxv35 authors: Vindrola-Padros, C.; Singh, K.; Sidhu, M. S.; Georghiou, T.; Sherlaw-Johnson, C.; Tomini, S. M.; Inada-Kim, M.; Kirkham, K.; Streetly, A.; Fulop, N. J. title: Remote home monitoring (virtual wards) during the COVID-19 pandemic: a living systematic review date: 2020-10-09 journal: nan DOI: 10.1101/2020.10.07.20208587 sha: doc_id: 277178 cord_uid: nbotxv35 Objectives: The aim of this review was to analyse the implementation and impact of remote home monitoring models (virtual wards) during COVID-19, identifying their main components, processes of implementation, target patient populations, impact on outcomes, costs and lessons learnt. Setting: The review included remote home monitoring models led by primary and secondary care across seven countries. keywords: articles; care; covid-19; home; models; monitoring; patient; preprint; review cache: cord-277178-nbotxv35.txt plain text: cord-277178-nbotxv35.txt item: #1159 of 2876 id: cord-277189-fe8ego7f author: Szabados, Bernadett title: Clinical Characteristics and Outcome for Four SARS-CoV-2-infected Cancer Patients Treated with Immune Checkpoint Inhibitors date: 2020-05-26 words: 1705 flesch: 49 summary: Eur Urol DOI: 10.1016/j.eururo.2020.05.024 sha: doc_id: 277189 cord_uid: fe8ego7f Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with higher mortality among cancer patients, particularly in those on systemic therapy. Preliminary data suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 ) is associated with higher mortality among cancer patients [1] . keywords: cancer; covid-19; patients; treatment cache: cord-277189-fe8ego7f.txt plain text: cord-277189-fe8ego7f.txt item: #1160 of 2876 id: cord-277201-jzjxsetx author: Mazo, Jahinover title: More than Just Pneumonia: Acute Pulmonary Embolism in Two Middle-Aged Patients with COVID-19 date: 2020-07-30 words: 2652 flesch: 40 summary: Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China Early clinical and CT manifestations of coronavirus disease 2019 (COVID-19) pneumonia Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT Angiography Pulmonary embolism and increased levels of d-dimer in patients with coronavirus disease e emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Hypercoagulability of COVID-19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis Characteristics of ischaemic stroke associated with COVID-19 e use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): the perspectives of clinical immunologists from China romboinflammation and the hypercoagulability of COVID-19 e procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Hyperinflammation and derangement of renin-angiotensinaldosterone system in COVID-19: a novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis Cytokines as Regulators of Coagulation Prevention, diagnosis, and treatment of VTE in patients with COVID-19 Predictive and associative models to identify hospitalized medical patients at risk for VTE Modified IM-PROVE VTE risk score and elevated D-dimer identify a high venous thromboembolism risk in acutely ill medical population for extended thromboprophylaxis A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score rombosis risk assessment as a guide to quality patient care romboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum Practical diagnosis and treatment of suspected venous thromboembolism during COVID-19 pandemic According to data from China, where the virus originated, 87% of COVID-19 patients were between the age 30-79 years keywords: covid-19; factors; patients; pulmonary; risk; thromboembolism; vte cache: cord-277201-jzjxsetx.txt plain text: cord-277201-jzjxsetx.txt item: #1161 of 2876 id: cord-277207-2my86ums author: Zhou, H. title: Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19) date: 2020-04-15 words: 3612 flesch: 45 summary: We also presented bone marrow aspiration pathology of three patients with delayed phase thrombocytopenia, showing impaired maturation of megakaryocytes. Thrombocytopenia at admission was prevalent, while late phase or delayed phase thrombocytopenia is obscure. keywords: covid-19; medrxiv; patients; phase; platelet; preprint; study; thrombocytopenia cache: cord-277207-2my86ums.txt plain text: cord-277207-2my86ums.txt item: #1162 of 2876 id: cord-277210-xaj2623u author: Weinkove, Robert title: Managing haematology and oncology patients during the COVID‐19 pandemic: interim consensus guidance date: 2020-05-13 words: 6047 flesch: 32 summary: 10 Atypical clinical presentations of other infections are common among cancer patients receiving highly immunosuppressive therapies, 13 although whether this applies to COVID- 19 is not yet known. This may be of particular relevance to patients with lung cancer, who made up the majority of cancer patients affected by COVID-19 in an early report. keywords: cancer; care; cell; clinicians; cov-2; covid-19; guidance; health; infection; pandemic; patients; risk; sars; transfusion; treatment cache: cord-277210-xaj2623u.txt plain text: cord-277210-xaj2623u.txt item: #1163 of 2876 id: cord-277260-7se220oz author: Gosain, Rohit title: COVID-19 and Cancer: a Comprehensive Review date: 2020-05-08 words: 5943 flesch: 35 summary: However, in cancer patients on active treatment or even during watchful observation, lymphopenia (an independent poor prognostic indicator in COVID-19 patients) Emerging data highlighting concerns of coagulopathy in COVID-19 patients is becoming available, but it is too early to infer if these are more or less common in cancer patients [77] . keywords: cancer; china; coronavirus; cov-2; covid-19; disease; infection; pandemic; patients; risk; sars; syndrome; therapy; treatment; trials; use cache: cord-277260-7se220oz.txt plain text: cord-277260-7se220oz.txt item: #1164 of 2876 id: cord-277323-jqr2hkv2 author: Thampi, Swapna title: Considerations for resuscitation and transfer of paediatric patients with COVID-19 date: 2020-04-27 words: 263 flesch: 32 summary: key: cord-277323-jqr2hkv2 authors: Thampi, Swapna; Melvin Lee, Chang Chuan; Zhi Ng, Beatrice Hui; Anne Yap, Andrea Pek title: Considerations for resuscitation and transfer of paediatric patients with COVID-19 date: 2020-04-27 journal: 6 As the pandemic spreads, we will encounter more paediatric patients with COVID-19 disease who require resuscitation and transfer. keywords: patients cache: cord-277323-jqr2hkv2.txt plain text: cord-277323-jqr2hkv2.txt item: #1165 of 2876 id: cord-277328-9s8fwg1h author: Zhuang, Yuandi title: Dynamic changes on chest CT of COVID-19 patients with solitary pulmonary lesion in initial CT date: 2020-09-04 words: 3927 flesch: 54 summary: key: cord-277328-9s8fwg1h authors: Zhuang, Yuandi; Lin, Liaoyi; Xu, Xunhua; Xia, Tianyi; Yu, Huili; Fu, Gangze; Yang, Yunjun; Wang, Meihao; Sun, Houzhang title: Dynamic changes on chest CT of COVID-19 patients with solitary pulmonary lesion in initial CT date: 2020-09-04 journal: a At the first chest CT scan (day 1), a ground-glass lesion with partial consolidation was shown in the subpleural area of the right lower lobe; b at peak time (day 10), the lesion in the right lower lobe expanded with interlobular septal thickening and consolidation, and new lesions appeared in the upper lobes; c before discharge (day 17), the lesions were gradually absorbed and linear opacities were observed in the bilateral upper lobes; d after discharge (day 51), chest CT scan showed few GGO in the right lung, and the consolidation and linear opacities disappeared Fig. keywords: chest; covid-19; discharge; patients; score; time cache: cord-277328-9s8fwg1h.txt plain text: cord-277328-9s8fwg1h.txt item: #1166 of 2876 id: cord-277399-0w8is9xm author: Esteves, Sandro C. title: SARS‐CoV‐2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services date: 2020-05-22 words: 4162 flesch: 31 summary: key: cord-277399-0w8is9xm authors: Esteves, Sandro C.; Lombardo, Francesco; Garrido, Nicolás; Alvarez, Juan; Zini, Armand; Colpi, Giovanni M.; Kirkman‐Brown, Jackson; Lewis, Sheena E. M.; Björndahl, Lars; Majzoub, Ahmad; Cho, Chak‐Lam; Vendeira, Pedro; Hallak, Jorge; Amar, Edouard; Cocuzza, Marcello; Bento, Fabiola C.; Figueira, Rita C.; Sciorio, Romualdo; Laursen, Rita J.; Metwalley, Ahmad M.; Jindal, Sunil K.; Parekattil, Sijo; Ramasamy, Ranjith; Alviggi, Carlo; Humaidan, Peter; Yovich, John L.; Agarwal, Ashok title: SARS‐CoV‐2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services date: 2020-05-22 journal: Andrology DOI: 10.1111/andr.12809 sha: doc_id: 277399 cord_uid: 0w8is9xm The prolonged lockdown of health facilities providing non‐urgent gamete cryopreservation—as currently recommended by many reproductive medicine entities and regulatory authorities due to the SARS‐CoV‐2 pandemic will be detrimental for subgroups of male infertility patients. keywords: banking; cov-2; fertility; male; men; patients; sars; semen; services; sperm cache: cord-277399-0w8is9xm.txt plain text: cord-277399-0w8is9xm.txt item: #1167 of 2876 id: cord-277430-x02u7oh0 author: Zhang, Hongyan title: Outcomes of novel coronavirus disease 2019 (COVID‐19) infection in 107 patients with cancer from Wuhan, China date: 2020-06-23 words: 3188 flesch: 38 summary: French consensus on management of head and neck cancer surgery during COVID-19 pandemic A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Information for laboratories about coronavirus (COVID-19) key: cord-277430-x02u7oh0 authors: Zhang, Hongyan; Wang, Linwei; Chen, Yuanyuan; Wu, Qiuji; Chen, Gaili; Shen, Xiaokun; Wang, Qun; Yan, Youqin; Yu, Yi; Zhong, Yahua; Wang, Xinghuan; Chua, Melvin L. K.; Xie, Conghua title: Outcomes of novel coronavirus disease 2019 (COVID‐19) infection in 107 patients with cancer from Wuhan, China date: 2020-06-23 journal: Cancer DOI: 10.1002/cncr.33042 sha: doc_id: 277430 cord_uid: x02u7oh0 BACKGROUND: Patients with cancer have a higher risk of coronavirus disease 2019 (COVID‐19) than noncancer patients. keywords: anticancer; cancer; covid-19; patients; study; treatment; wuhan cache: cord-277430-x02u7oh0.txt plain text: cord-277430-x02u7oh0.txt item: #1168 of 2876 id: cord-277486-12uah5qi author: Kopp, Kristen title: Interdisciplinary Model for Scheduling Post-discharge Cardiopulmonary Care of Patients Following Severe and Critical SARS-CoV-2 (Coronavirus) Infection date: 2020-08-14 words: 3182 flesch: 20 summary: In another CT study of convalescing SARS patients 51 days after symptom start, follow-up CT showed air trapping (92%) ground-glass opacities As no guidelines on the timing of follow-up care for Covid-19 patients yet exist, this model schedules follow-up to occur at 1-2 months post-discharge based on several considerations. keywords: care; covid-19; discharge; disease; follow; infection; patients; pulmonary; sars cache: cord-277486-12uah5qi.txt plain text: cord-277486-12uah5qi.txt item: #1169 of 2876 id: cord-277498-hdhq99k2 author: Chua, Melvin L.K. title: Follow-up and management of head and neck cancer patients during the 2019 novel coronavirus (SARS-CoV-2) disease pandemic date: 2020-05-15 words: 3347 flesch: 40 summary: Cancer patients constitute a particularly vulnerable population during this outbreak due to their potentially compromised immune system and the frequency of their healthcare visits. Several groups have shared their approach to managing cancer patients during this global outbreak 3, 4 . keywords: cancer; head; neck; patients; radiation; sars; treatment; visits cache: cord-277498-hdhq99k2.txt plain text: cord-277498-hdhq99k2.txt item: #1170 of 2876 id: cord-277535-u283k70i author: Vaja, Rakesh title: Drugs and the liver date: 2020-09-22 words: 4015 flesch: 45 summary: Prevalence of ultrarapid metabolisers Metabolism of drugs in liver disease depends on liver blood flow. NSAIDS are contraindicated for systemic use in most liver disease patients, because of increased bioavalibilty, the high risk of precipitating gastrointestinal bleeding and renal failure. keywords: blood; codeine; disease; dose; drugs; failure; liver; metabolism; paracetamol; patients cache: cord-277535-u283k70i.txt plain text: cord-277535-u283k70i.txt item: #1171 of 2876 id: cord-277539-xt2nt11e author: Kochhar, Anuraj Singh title: Dentistry during and after COVID-19 Pandemic: Pediatric Considerations date: 2020 words: 4508 flesch: 41 summary: It is highly likely that dental professionals in upcoming days will come across COVID-19 patients and SARS-CoV-2 carriers, and hence must ensure a tactful handling of such patients to prevent its nosocomial spread. It is speculated that dental professionals will come across COVID-19 patients and SARS-CoV-2 carriers, and hence must ensure a careful handling of such patients to prevent its nosocomial spread. keywords: coronavirus; cov-2; covid-19; disease; infection; pandemic; patients; practice; sars; transmission; use cache: cord-277539-xt2nt11e.txt plain text: cord-277539-xt2nt11e.txt item: #1172 of 2876 id: cord-277576-3dvt6uj7 author: Demir, Erol title: COVID‐19 in kidney transplant recipients: A multicenter experience in Istanbul date: 2020-07-13 words: 2243 flesch: 47 summary: However, it is unclear which markers are useful for the monitoring of kidney transplant recipient patients. 8, 9 Acute kidney injury is also associated with increased morbidity and mortality in COVID-19 patients. keywords: covid-19; kidney; patients; pneumonia; recipients; study; transplant cache: cord-277576-3dvt6uj7.txt plain text: cord-277576-3dvt6uj7.txt item: #1173 of 2876 id: cord-277643-xh8z9v0m author: Khatiwada, Asmita Priyadarshini title: Paradigm shift of drug information centers during the COVID-19 pandemic date: 2020-07-20 words: 3933 flesch: 32 summary: DICs can also greatly aid HCPs by providing current, complete, and accurate information on drug therapy and management approaches for treating COVID-19 patients with various comorbid conditions based on the scientific literature, and national and international guidelines. Given data from ongoing trials and emerging studies suggesting that hydroxychloroquine and chloroquine do not help to decrease the mortality or speed the recovery of COVID-19 patients, and the potential for life-threatening heart rhythm problems, the FDA withdrew the EUA for their use in COVID-19 [38] . keywords: covid-19; dics; disease; drug; hcps; health; information; patients; pharmacists cache: cord-277643-xh8z9v0m.txt plain text: cord-277643-xh8z9v0m.txt item: #1174 of 2876 id: cord-277700-nxm1jr0x author: Chassagnon, Guillaume title: AI-Driven CT-based quantification, staging and short-term outcome prediction of COVID-19 pneumonia date: 2020-04-22 words: 4884 flesch: 44 summary: [22] [23] , which share common CT features with COVID-19 pneumonia, especially a predominance of ground glass opacities. Disease extent is the only parameter that can be visually estimated on chest CT to quantify disease severity 4, 5 , but visual quantification is difficult and usually coarse. keywords: chest; covid-19; disease; features; lung; network; patients; prognosis; segmentation; training cache: cord-277700-nxm1jr0x.txt plain text: cord-277700-nxm1jr0x.txt item: #1175 of 2876 id: cord-277739-eb4z3u66 author: Hu, Ke title: Efficacy and Safety of Lianhuaqingwen Capsules, a repurposed Chinese Herb, in Patients with Coronavirus disease 2019: A multicenter, prospective, randomized controlled trial date: 2020-05-16 words: 3673 flesch: 41 summary: To determine the safety and efficacy of LH capsule in patients with Covid-19. We did a prospective multicenter open-label randomized controlled trial on LH capsule in confirmed cases with Covid-19. keywords: capsules; covid-19; group; patients; rate; recovery; sars; study; treatment cache: cord-277739-eb4z3u66.txt plain text: cord-277739-eb4z3u66.txt item: #1176 of 2876 id: cord-277803-7p1qu2rf author: Rubino, Francesco title: Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery date: 2020-05-07 words: 6092 flesch: 25 summary: National diabetes statistics report 2020: estimates of diabetes and its burden in the United States Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study Predictors of mortality over 8 years in type 2 diabetic patients: Translating Research Into Action for Diabetes (TRIAD) Risk factors for mortality among patients with diabetes: the Translating Research Into Action for Diabetes (TRIAD) Study Years of life lost due to obesity Morbidity and mortality associated with obesity Prevalence and ethnicity of sleep-disordered breathing and obesity in children Adiposity in relation to age as predictor of severity of sleep apnea in children with snoring Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome Combining risk estimates from observational studies with different exposure cutpoints: a meta-analysis on body mass index and diabetes type 2 Body mass index, abdominal fatness, and heart failure incidence and mortality: a systematic review and dose-response meta-analysos of prospective studies Emerging concepts in the medical and surgical treatment of obesity Using the Edmonton Obesity Staging System to predict mortality in a population-representative cohort of people with overweight and obesity Edmonton Obesity Staging System: association with weight history and mortality risk Non-alcoholic fatty liver disease Practical approach to non-alcoholic fatty liver disease in patients with diabetes Nonalcoholic fatty liver disease and risk of incident type 2 diabetes: a meta-analysis Nonalcoholic fatty liver disease increases risk of incident chronic kidney disease: a systematic review and meta-analysis NAFLD and diabetes mellitus Nonalcoholic fatty liver disease: a systematic review The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe Bariatric surgery versus intensive medical therapy for diabetes-5-year outcomes Microvascular outcomes in patients with diabetes after bariatric surgery versus usual care: a matched cohort study Bariatric surgery for non-alcoholic steatohepatitis in obese patients Bariatric surgery reduces features of nonalcoholic steatohepatitis in morbidly obese patients Lifestyle intervention and medical management with vs without Roux-en-Y gastric bypass and control of hemoglobin A1c, LDL cholesterol, and systolic blood pressure at 5 years in the Diabetes Surgery Study Bariatric-metabolic surgery versus conventional medical treatment in obese patients with type 2 diabetes: 5 year follow-up of an open-label, single-centre, randomised controlled trial Clinical and patient-centered outcomes in obese patients with type 2 diabetes 3 years after randomization to Rouxen-Y gastric bypass surgery versus intensive lifestyle management: the SLIMM-T2D study Survival among high-risk patients after bariatric surgery A simple prediction rule for all-cause mortality in a cohort eligible for bariatric surgery Long-term mortality after gastric bypass surgery Long-term mortality rates (>8-year) improve as compared to the general and obese population following bariatric surgery Survival and changes in comorbidities after bariatric surgery Predictors of long-term mortality after bariatric surgery performed in Veterans Affairs medical centers Cancer risk following bariatric surgery-systematic review and meta-analysis of national population-based cohort studies Bariatric surgery and the risk of cancer in a large multisite cohort Bariatric surgery is associated with reduced risk of breast cancer in both premenopausal and postmenopausal women Bariatric surgery is associated with a lower rate of death after myocardial infarction and stroke: a nationwide study Success (but unfinished) story of metabolic surgery Metabolic surgery for the treatment of type 2 diabetes in obese individuals Clinical outcomes of metabolic surgery: efficacy of glycemic control, weight loss, and remission of diabetes Cost-effectiveness of bariatric surgery for severely obese adults with diabetes Preoperative Prediction of type 2 diabetes remission after gastric bypass surgery: a comparison of DiaRem scores and ABCD scores Type 2 diabetes remission 2 years post Roux-en-Y gastric bypass and sleeve gastrectomy: the role of the weight loss and comparison of DiaRem and DiaBetter scores The advanced-DiaRem score improves prediction of diabetes remission 1 year post-Roux-en-Y gastric bypass Preoperative prediction of type 2 diabetes remission after Roux-en-Y gastric bypass surgery: a retrospective cohort study Validating risk prediction models of diabetes remission after sleeve gastrectomy Incidence and remission of type 2 diabetes in relation to degree of obesity at baseline and 2 year weight change: the Swedish Obese Subjects (SOS) study Health care use during 20 years following bariatric surgery Impact of bariatric surgery on health care costs of obese persons: a 6-year follow-up of surgical and comparison cohorts using health plan data The business case for bariatric surgery revisited: a non-randomized case-control study Long-term expenditures associated with bariatric surgery in VA Association between bariatric surgery and long-term health care expenditures among veterans with severe obesity Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes-2020 Efficacy and safety of sodium-glucose cotransporter 2 inhibitors (SGLT-2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) in patients with type 2 diabetes: a systematic review and network meta-analysis study protocol Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials Consensus recommendations for the management of diabetes in patients with COVID-19 Diets with high or low protein content and glycemic index for weight-loss maintenance Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/ topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial Joint international consensus statement for ending stigma of obesity Bariatric, metabolic, and diabetes surgery: what's in a name? Related factors of quality of life of type 2 diabetes patients: a systematic review and meta-analysis Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus Bariatric surgery has been used for decades to treat patients with severe obesity. keywords: candidates; complications; covid-19; diabetes; disease; metabolic; mortality; obesity; patients; risk; surgery; type; weight cache: cord-277803-7p1qu2rf.txt plain text: cord-277803-7p1qu2rf.txt item: #1177 of 2876 id: cord-277811-j58qvyum author: Mehrani, Hossein title: Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis date: 2011-01-07 words: 4100 flesch: 48 summary: Plasma proteins and peptides are from almost every tissue and cell, and their change in quantity and quality is specific not only to the tissue affected by disease, but also to the disease process itself. P50% S75% P75% Figure 1 SDS-PAGE of plasma proteins fractionated with different concentrations (v/v) of ethanol. keywords: analysis; controls; disease; ethanol; haptoglobin; lung; patients; plasma; proteins; spots cache: cord-277811-j58qvyum.txt plain text: cord-277811-j58qvyum.txt item: #1178 of 2876 id: cord-277818-8w15dz20 author: Jaichenco, Andre L. title: Infectious Disease Considerations for the Operating Room date: 2018-02-09 words: 9732 flesch: 31 summary: Gloves protect patients by reducing health care provider hand contamination and the subsequent transmission of pathogens to other children, provided the gloves are changed after providing care to each child. 10 Direct and indirect contacts are the most significant and frequent methods of hospital infection transmission. keywords: anesthesia; blood; care; children; contamination; exposure; gloves; guidelines; hand; health; hygiene; infection; patient; pediatric; prophylaxis; providers; risk; skin; transmission; use cache: cord-277818-8w15dz20.txt plain text: cord-277818-8w15dz20.txt item: #1179 of 2876 id: cord-277889-8u685f45 author: Costela-Ruiz, Víctor J. title: SARS-CoV-2 infection: the role of cytokines in COVID-19 disease date: 2020-06-02 words: 9237 flesch: 42 summary: With respect to viral infections that target the respiratory system, Bot et al. observed that its expression during infection with an influenza virus had negative effects on CD8 + memory T cells [71] .Various studies of COVID-19 patients have detected elevated IL-4 levels as part of the cytokine storm associated with severe respiratory symptoms [16, 17, 43, 72] . f a subunit of the murine GM-CSF receptor A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF Molecular analysis of the granulocyte colony-stimulating factor receptor Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages Studies on the bone marrow colony stimulating factor (CSF): relation of tissue CSF to serum CSF IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects Pivotal roles of GM-CSF in autoimmunity and inflammation IP-10 in autoimmune thyroiditis TRAIL and IP-10 as biomarkers of viral infections in the emergency J o u r n a l P r e -p r o o f department Interferon gamma in autoimmunity: A complicated player on a complex stage MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Monocyte chemoattractant protein-1 (MCP-1): an overview Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs COVID-19: keywords: cells; coronavirus; cov-2; covid-19; csf; cytokines; disease; factor; il-10; il-6; infection; levels; lung; patients; sars; study cache: cord-277889-8u685f45.txt plain text: cord-277889-8u685f45.txt item: #1180 of 2876 id: cord-277992-49mantab author: Harikrishnan, S. title: Cardiological society of India position statement on COVID-19 and heart failure date: 2020-05-13 words: 2476 flesch: 38 summary: COVID-19 patients who are diagnosed as having asymptomatic left ventricular systolic dysfunction or clinically overt heart failure should receive standard guideline directed therapy. This is especially true since heart failure patients may not mount fever. keywords: cardiac; china; coronavirus; covid-19; disease; failure; heart; patients cache: cord-277992-49mantab.txt plain text: cord-277992-49mantab.txt item: #1181 of 2876 id: cord-278106-ev1nx60h author: Cancarevic, Ivan title: Coronavirus Disease 2019 (COVID-19) in Cancer Patients date: 2020-04-26 words: 2480 flesch: 46 summary: Cancer patients have weaker immune systems compared to the general population, both due to the disease itself as well as the treatment. As such, morbidity and mortality of any serious infections would be expected to be high among cancer patients. keywords: cancer; cov-2; covid-19; patients; sars cache: cord-278106-ev1nx60h.txt plain text: cord-278106-ev1nx60h.txt item: #1182 of 2876 id: cord-278256-dmrtsxik author: Qiu, Haiyan title: Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study date: 2020-03-25 words: 3460 flesch: 47 summary: Fewer children with COVID-19 had obvious symptoms compared with adult patients with COVID-19 and paediatric patients with H1N1 influenza described in previous studies. The comparison of paediatric patients with COVID-19 with adult patients with COVID-19 in the same city (table 3) showed that paediatric patients had a significantly lower prevalence of abnormal values of several variables indicating disease severity, such as fever (36% for children and 86% for adults), cough (19% and 62%), pneumonia (53% and 95%), elevated C-reactive protein (3% and 49%), and severe disease type (0% and 23%; p<0·0001 for all features). keywords: children; coronavirus; covid-19; fever; patients; pneumonia; sars cache: cord-278256-dmrtsxik.txt plain text: cord-278256-dmrtsxik.txt item: #1183 of 2876 id: cord-278300-6cr9h7no author: Lu, X. title: Classification of COVID-19 in intensive care patients: towards rational and effective clinical triage date: 2020-04-11 words: 1273 flesch: 40 summary: The study is limited by ignoring the effect of treatment, but we believe that such classification of COVID-19 in intensive care patients could help in early warning of the disease and would provide effective triage for the treatment and management of individual patients, allowing for a more rational allocation of scarce medical resources in a resource constrained environment. key: cord-278300-6cr9h7no authors: Lu, X.; Wang, Y.; Chen, T.; Li, Y.; Wang, J.; Yan, F. title: Classification of COVID-19 in intensive care patients: towards rational and effective clinical triage date: 2020-04-11 journal: nan DOI: 10.1101/2020.04.09.20058909 sha: doc_id: 278300 cord_uid: 6cr9h7no The number of pertinent researches of COVID-19 has increased rapidly but they mainly focused on the description of general information of patients with confirmed infection. keywords: care; data; patients; preprint cache: cord-278300-6cr9h7no.txt plain text: cord-278300-6cr9h7no.txt item: #1184 of 2876 id: cord-278319-44bvju3g author: Gonzales, Ralph title: Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: Background date: 2001-06-30 words: 4806 flesch: 31 summary: Noninfectious causes of uncomplicated acute bronchitis, such as occult asthma exacerbation or toxic fume inhalation, should also be considered, although the prevalence of these conditions in adults with acute cough illness has not been well studied. When evaluating an otherwise healthy adult with uncomplicated acute cough illness, the primary diagnostic objective should be to exclude the presence of pneumonia. keywords: adults; antibiotic; bronchitis; cough; duration; illness; influenza; patients; pneumonia; treatment cache: cord-278319-44bvju3g.txt plain text: cord-278319-44bvju3g.txt item: #1185 of 2876 id: cord-278325-ykcd7d59 author: Cheung, Carmen Ka Man title: Coronavirus Disease 2019 (COVID-19): A Haematologist's Perspective date: 2020-07-28 words: 7682 flesch: 35 summary: Thrombocytopenia, coagulation abnormalities, and disseminated intravascular coagulation were observed in COVID-19 patients, especially those with critical illness and non-survivors. [45] evaluated lymphocyte subsets in 103 patients, which revealed that CD3+, CD4+, and CD8+ T cells and NK cells were significantly decreased in COVID-19 patients with a more severe decrease in CD8+ T cells compared with CD4+ T cells. keywords: admission; blood; cells; clinical; coronavirus; cov-2; covid-19; disease; infection; lymphocyte; non; patients; platelet; risk; sars; study; treatment cache: cord-278325-ykcd7d59.txt plain text: cord-278325-ykcd7d59.txt item: #1186 of 2876 id: cord-278332-fbksw3om author: Schlick, Cary Jo R. title: Adequate Lymphadenectomy as a Quality Measure in Esophageal Cancer: Is there an Association with Treatment Approach? date: 2020-06-09 words: 3947 flesch: 32 summary: The national comprehensive cancer network defines adequate lymphadenectomy as evaluation of ≥ 15 lymph nodes in esophageal cancer. Our objectives were to (1) explore trends in adequate lymphadenectomy rates over time; (2) evaluate unadjusted lymphadenectomy yield by treatment characteristics; and (3) identify independent factors associated with adequate lymphadenectomy. keywords: cancer; esophageal; esophagectomy; lymphadenectomy; nodes; patients; study; therapy cache: cord-278332-fbksw3om.txt plain text: cord-278332-fbksw3om.txt item: #1187 of 2876 id: cord-278364-58d8kfdf author: Mohapatra, S. title: Sterilization and Disinfection date: 2017-03-31 words: 6550 flesch: 46 summary: Society for health care epidemiology of America Infection control in the bronchoscopy suite Medicine and health care products manual New developments in reprocessing semicritical items Importance of the environment in the methicillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaning Protecting HCWs from SARS and other respiratory pathogens: a review of the infection control literature Modes of transmission of respiratory syncytial virus Gastroenteritis outbreak with norovirus in a Swiss university hospital with a newly identified virus strain CDC definitions for nosocomial infections CDC definitions for nosocomial infections Guidelines on prevention and control of hospital associated infections. There are many issues regarding nonendoscopic transmission of various infections. keywords: air; care; cleaning; control; disinfection; equipment; health; hospital; infection; items; patient; sterilization; surfaces; transmission cache: cord-278364-58d8kfdf.txt plain text: cord-278364-58d8kfdf.txt item: #1188 of 2876 id: cord-278477-9a7gmzz3 author: Huh, Kyungmin title: Impact of obesity, fasting plasma glucose level, blood pressure, and renal function on the severity of COVID-19: a matter of sexual dimorphism? date: 2020-10-21 words: 3235 flesch: 44 summary: Propensity scores (PS) of severe COVID-19 risk were calculated using logistic regression with the following covariates: age, sex, coverage for low income, and CCI. This retrospective study compared BP, and metabolic and kidney function parameters between COVID-19 patients with severe disease (including fatalities) and those with mild-tomoderate disease. keywords: covid-19; disease; health; levels; patients; risk; sex; study cache: cord-278477-9a7gmzz3.txt plain text: cord-278477-9a7gmzz3.txt item: #1189 of 2876 id: cord-278536-b4eyegx5 author: Piazza, Gregory title: Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 date: 2020-11-03 words: 1472 flesch: 25 summary: Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in COVID-19 and haemostasis: a position paper from Italian Society on Thrombosis and Haemostasis (SISET) Incidence of venous thromboembolism in hospitalized patients with COVID-19 Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 Endothelial cell infection and endotheliitis in COVID-19 Autopsy findings and venous thromboembolism in patients with COVID-19 Prevention, diagnosis and treatment of VTE in patients with coronavirus disease 2019: CHEST guideline and expert panel report Scientific and Standardization Committee communication: clinical guidance on the diagnosis, prevention and treatment of venous thromboem Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19 Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support Third universal definition of myocardial infarction Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients A proportional hazards model for the subdistribution of a competing risk Bias reduction of maximum likelihood estimates Impact of cardiovascular disease and cardiac injury on in-hospital mortality in patients with COVID-19: a systematic review and meta-analysis Acute pulmonary embolism and COVID-19 Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis Pharmacological agents targeting thromboinflammation in COVID-19: review and implications for future research Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels key: cord-278536-b4eyegx5 authors: Piazza, Gregory; Campia, Umberto; Hurwitz, Shelley; Snyder, Julia E.; Rizzo, Samantha M.; Pfeferman, Mariana B.; Morrison, Ruth B.; Leiva, Orly; Fanikos, John; Nauffal, Victor; Almarzooq, Zaid; Goldhaber, Samuel Z. title: Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 date: 2020-11-03 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.08.070 sha: doc_id: 278536 cord_uid: b4eyegx5 BACKGROUND: Cardiovascular complications, including myocardial infarction, ischemic stroke, and pulmonary embolism, represent an important source of adverse outcomes in coronavirus disease-2019 (COVID-19). keywords: arterial; care; cohort; covid-19; patients cache: cord-278536-b4eyegx5.txt plain text: cord-278536-b4eyegx5.txt item: #1190 of 2876 id: cord-278547-y0hvq0qf author: Testori, Alberto title: Extraordinary emergency measures set up by a Breast Unit to prevent COVID‐19: Report of our experience date: 2020-06-25 words: 688 flesch: 45 summary: Mastectomy without reconstruction or quadrantectomy with sentinel lymph node biopsy and axillary dissection were performed on day surgery regimen, and patient was discharged directly from recovery room. We believe A novel coronavirus from patients with pneumonia in China A pneumonia outbreak associated with a new coronavirus of probable bat origin Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. keywords: covid-19; patients; surgery cache: cord-278547-y0hvq0qf.txt plain text: cord-278547-y0hvq0qf.txt item: #1191 of 2876 id: cord-278549-br9rr713 author: Madanelo, M. title: The impact of the COVID‐19 pandemic on the utilization of emergency urological services date: 2020-05-14 words: 1718 flesch: 47 summary: However, significantly fewer female patients sought emergency urological services during the COVID‐19 pandemic period (32.7% vs. 14.8%, p<0.05). However, significantly fewer female patients sought emergency urological services during the COVID-19 pandemic period (32.7% vs. 14.8%, p<0.05). keywords: emergency; pandemic; patients; period cache: cord-278549-br9rr713.txt plain text: cord-278549-br9rr713.txt item: #1192 of 2876 id: cord-278592-67y4f9av author: Kurup, Asok title: Control of a hospital-wide vancomycin-resistant Enterococci outbreak date: 2008-03-24 words: 3045 flesch: 46 summary: Despite such measures as screening patients sharing rooms with index cases and isolating VRE patients, 43 isolates from different wards were detected by the end of March 2005. Co-colonization and/or co-infection with MRSA was present in 52 of 151 (34%) VRE cases. keywords: cases; control; hospital; outbreak; patients; screening; vancomycin; vre cache: cord-278592-67y4f9av.txt plain text: cord-278592-67y4f9av.txt item: #1193 of 2876 id: cord-278672-pxzsntfg author: Milenkovic, Aleksandar title: Extensions and Adaptations of Existing Medical Information System in Order to Reduce Social Contacts During COVID-19 Pandemic date: 2020-06-16 words: 4611 flesch: 41 summary: Before the beginning of COVID-19 pandemic MIS MEDIS.NET did not have specifically developed software functionalities (modules, subsystems) which would help healthcare workers and patients to combat seasonal and exceptional pandemics. The therapy of chronic patients has been prolonged for 6 months via an electronic prescription. keywords: covid-19; data; disease; health; information; mis; pandemic; patients; system cache: cord-278672-pxzsntfg.txt plain text: cord-278672-pxzsntfg.txt item: #1194 of 2876 id: cord-278682-s4gfbsqy author: Chan, W-M title: Precautions in ophthalmic practice in a hospital with a major acute SARS outbreak: an experience from Hong Kong date: 2005-04-29 words: 4133 flesch: 42 summary: For patients presenting with fever, contact history of SARS patients within 10 days, or recovered SARS patients shortly discharged from hospital, we have adopted a special outpatient follow-up strategy based on initial epidemiological and microbiological evidences that the main mode of transmission of SARS is by droplets, direct contact with patient's secretions, and subsequent inoculation into mucous membranes. The ultimate infectivity of the tears secretion and ocular discharge from SARS patients may bring impacts on not only the daily ophthalmic practice but also the universal infection control measures practiced by general public and health-care workers. keywords: care; contact; control; eye; health; infection; measures; outbreak; patients; sars cache: cord-278682-s4gfbsqy.txt plain text: cord-278682-s4gfbsqy.txt item: #1195 of 2876 id: cord-278838-qraq5aho author: Mirouse, Adrien title: Severe varicella-zoster virus pneumonia: a multicenter cohort study date: 2017-06-07 words: 4705 flesch: 40 summary: Patients receiving steroids were matched in a 1:6 ratio to a control group of patients within this cohort who did not receive steroids. Patients receiving steroids were matched in a 1:6 ratio to a control group of patients within this cohort who did not receive steroids. keywords: admission; cap; icu; infection; patients; pneumonia; steroids; study; ventilation; vzv cache: cord-278838-qraq5aho.txt plain text: cord-278838-qraq5aho.txt item: #1196 of 2876 id: cord-278937-lkuuftno author: Beydon, N. title: Lung function testing during a pandemic: an international perspective date: 2020-10-11 words: 1873 flesch: 41 summary: Influenza Other Respir Viruses Pulmonary Function Laboratories: Advice Regarding COVID-19 Italian pediatric respiratory society recommendations on pediatric pulmonary function testing during COVID-19 pandemic. Considering that there is a possibility of disease transmission to the patients and staff from asymptomatic carriers, precautions for pulmonary function testing (PFT) laboratories have been controversial (5) . keywords: covid-19; pandemic; patients; pft; testing cache: cord-278937-lkuuftno.txt plain text: cord-278937-lkuuftno.txt item: #1197 of 2876 id: cord-278943-f80ucqqp author: Calvillo-Argüelles, Oscar title: Modified Routine Cardiac Imaging Surveillance of Adult Cancer Patients and Survivors during the COVID-19 Pandemic date: 2020-04-16 words: 1651 flesch: 27 summary: Several modifications to routine cardiac imaging practices in cancer patients can be considered during the COVID-19 pandemic. Exposure to anthracycline as part of current or prior treatment ‡ During Treatment -Anthracycline Treatment ASCO -Routine imaging surveillance may be considered in asymptomatic patient patients considered at increased risk of cardiac dysfunction with frequency determined by health care provider based on clinical judgement(4) ESMO -after each additional 100 mg/m 2 beyond 250 mg/m 2 as (10) Repeat imaging early upon diagnosis of CTRCD to guide re-initiation of cancer therapy or titrate cardiac medications. individuals during pandemic, but return to institution specific protocols post-pandemic. keywords: cancer; ctrcd; imaging; patients; risk cache: cord-278943-f80ucqqp.txt plain text: cord-278943-f80ucqqp.txt item: #1198 of 2876 id: cord-278984-0zof6s4d author: El-Tallawy, Salah N. title: Pain Management During the COVID-19 Pandemic date: 2020-08-25 words: 6480 flesch: 42 summary: In light of the limited data available for COVID-19-related impact on chronic pain patients, this review explores the changes in the healthcare delivery system due to social distancing and safety precautions to provide the appropriate management of chronic pain patients during the COVID-19 pandemic. Understanding both the general problems facing chronic pain patients as well as specific problems in the COVID-19 era including deconditioning, increased mental health concerns, financial burdens, and potential for medication-induced immune-suppression is vital in the appropriate management of patients. keywords: care; chronic; covid-19; health; management; nsaids; opioid; pain; pandemic; patients; risk; treatment; use cache: cord-278984-0zof6s4d.txt plain text: cord-278984-0zof6s4d.txt item: #1199 of 2876 id: cord-278993-w5aa0elj author: Tonetti, Tommaso title: Use of critical care resources during the first 2 weeks (February 24–March 8, 2020) of the Covid-19 outbreak in Italy date: 2020-10-12 words: 3929 flesch: 37 summary: In patients treated outside the ICU, conventional O 2 therapy was applied in the 47.3% of the cases and non-invasive respiratory support (including NIV, CPAP and high-flow O 2 therapy) in the 52.7%, while 81.8% of ICU patients were intubated. Data regarding the impact of Covid-19 outbreak on the capacity of the health-care system to accomplish the need for ICU care are limited. keywords: beds; care; covid-19; data; icu; italy; non; outbreak; patients; resources; study; support cache: cord-278993-w5aa0elj.txt plain text: cord-278993-w5aa0elj.txt item: #1200 of 2876 id: cord-279052-8hxdfdls author: Boet, S. title: Protocol for a multicentre randomized controlled trial of normobaric versus hyperbaric oxygen therapy for hypoxemic COVID-19 patients date: 2020-07-16 words: 4134 flesch: 41 summary: 8, 17 Case series of HBOT treatment in hypoxemic COVID-19 patients from China, France and the United States show clinical benefits, e.g. reduced ICU admission and intubation rates. Approximately 15 to 20% of COVID-19 patients present with hypoxemic respiratory failure requiring oxygen supplementation. keywords: care; covid-19; hbot; hyperbaric; license; outcomes; oxygen; patients; preprint; trial cache: cord-279052-8hxdfdls.txt plain text: cord-279052-8hxdfdls.txt item: #1201 of 2876 id: cord-279056-mmcoqtb5 author: Seirafianpour, Farnoosh title: Cutaneous manifestations and considerations in COVID‐19 pandemic: A systematic review date: 2020-07-08 words: 4662 flesch: 35 summary: There were several drug regimens used for treatment of COVID-19 patients, some of which could result in cutaneous side effects like presence of a new dermatoses or flare/aggravation of a previous dermatologic disorder. Hydroxychloroquine; Despite the inconclusive result over the implication of Anti-Malarial drugs; it is used widely for treating COVID-19 patients. keywords: case; covid-19; infection; lesions; like; pandemic; patients; psoriasis; rash; skin; treatment cache: cord-279056-mmcoqtb5.txt plain text: cord-279056-mmcoqtb5.txt item: #1202 of 2876 id: cord-279111-jaa45kyc author: Ieven, M. title: Aetiology of lower respiratory tract infection in adults in primary care: a prospective study in 11 European countries date: 2018-02-12 words: 4083 flesch: 41 summary: Influenza virus, human parainfluenza viruses and human respiratory syncytial virus as well as human rhinovirus, human coronavirus and human metapneumovirus were detected significantly more frequently in LRTI patients than in controls. Influenza virus, human parainfluenza viruses and human respiratory syncytial virus as well as human rhinovirus, human coronavirus and human metapneumovirus were detected significantly more frequently in LRTI patients than in controls. keywords: bacterial; cap; care; lrti; pathogens; patients; pneumoniae; viruses cache: cord-279111-jaa45kyc.txt plain text: cord-279111-jaa45kyc.txt item: #1203 of 2876 id: cord-279134-s6c7m94h author: Chen, Haiyang title: When cancer encounters COVID-19 in China: what have we suffered, experienced and learned date: 2020-05-16 words: 4366 flesch: 39 summary: Here we share the experience of the medical management of cancer patients from China. In conclusion, although it is unclear whether cancer directly increases the incidence and risk of COVID-19 infection, it is certain that the prevalence of COVID-19 will have a significant impact on cancer patients both in terms of infection and receiving treatment for cancer. keywords: cancer; coronavirus; covid-19; epidemic; infection; lung; patients; risk; treatment cache: cord-279134-s6c7m94h.txt plain text: cord-279134-s6c7m94h.txt item: #1204 of 2876 id: cord-279158-dsnniuo6 author: Luo, Y. title: Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study date: 2020-05-22 words: 3906 flesch: 38 summary: In conclusion, we found that people with low serum sodium (hyponatremia) may be related to the susceptibility of SARS-CoV-2 infection and the development of severity of disease. key: cord-279158-dsnniuo6 authors: Luo, Y.; Li, Y.; Dai, J. title: Low blood sodium increases risk and severity of COVID-19: a systematic review, meta-analysis and retrospective cohort study date: 2020-05-22 journal: nan DOI: 10.1101/2020.05.18.20102509 sha: doc_id: 279158 cord_uid: dsnniuo6 Background Novel coronavirus (SARS-CoV-2) infects human lung tissue cells through angiotensin-converting enzyme-2 (ACE2), and the body sodium is an important factor for regulating the expression of ACE2. keywords: covid-19; medrxiv; patients; preprint; review; sars; serum; sodium; study cache: cord-279158-dsnniuo6.txt plain text: cord-279158-dsnniuo6.txt item: #1205 of 2876 id: cord-279197-cesemos0 author: Block, Keith I. title: Integrative Cancer Therapies: Learning From COVID-19 date: 2020-06-21 words: 4120 flesch: 31 summary: In this journal, Yan et al 2 discussed the use of traditional Chinese medicine therapies with cancer patients afflicted with COVID-19. They also raised an alarm about therapies like massage and acupuncture that involve close contact with patients, and suggest they be rigidly considered or forbidden for cancer patients in endemic areas, with stronger personal protection provisions for both patients and therapists. keywords: cancer; covid-19; curcumin; intravenous; patients; quercetin; resveratrol; therapies; treatment; trials; vitamin cache: cord-279197-cesemos0.txt plain text: cord-279197-cesemos0.txt item: #1206 of 2876 id: cord-279238-d49jvws2 author: Folesani, Gianluca title: Cardiac surgery model during COVID-19 pandemic: now it’s time to ramp up date: 2020-07-09 words: 505 flesch: 53 summary: We created a specific COVID-19 route for suspected patients with dedicated ICU beds and one operation room. Patients with underlying cardiovascular diseases have an increased risk of developing into the severe form of COVID-19 4 , while health-care workers are exposed to the risk of contagion or to become vectors of transmission. keywords: covid-19; patients cache: cord-279238-d49jvws2.txt plain text: cord-279238-d49jvws2.txt item: #1207 of 2876 id: cord-279299-5djtiomq author: CAO, HUI-FANG title: A confirmed severe case of human infection with avian-origin influenza H7N9: A case report date: 2014-12-30 words: 2564 flesch: 41 summary: With the added complications of the different baseline statuses of patients and the atypical clinical manifestations, dynamic monitoring of pulmonary imaging is particularly important for the early identification of lung infections and diseases, since viral pneumonia characteristic changes can be detected. For patients with renal insufficiency, continuous hemofiltration applied at the bedside may be the primary method for improving the prognosis. keywords: avian; blood; diagnosis; h7n9; infection; influenza; levels; patient cache: cord-279299-5djtiomq.txt plain text: cord-279299-5djtiomq.txt item: #1208 of 2876 id: cord-279357-83hisxro author: de Leon, Jose title: Clozapine is strongly associated with the risk of pneumonia and inflammation date: 2020-04-16 words: 4953 flesch: 39 summary: Until there is a better definition of clozapine PMs, we recommend considering Asian clozapine PMs as those who reach concentrations of 350 ng/mL with clozapine doses <150 6 Until a better definition of clozapine PMs in non-Asians is established, we recommend considering non-Asian clozapine PMs as those who reach 350 ng/mL with clozapine doses <300 mg/day. keywords: clozapine; day; dose; infection; inflammation; patients; pneumonia; risk cache: cord-279357-83hisxro.txt plain text: cord-279357-83hisxro.txt item: #1209 of 2876 id: cord-279396-qmixem8i author: Carter, Chris title: COVID-19 Disease: a critical care perspective date: 2020-06-01 words: 5308 flesch: 43 summary: With the rapid expansion of critical care services, current policies and guidelines may be unrealistic due to the differing levels of staffing, the large influx of new staff not familiar with critical care and the dynamic and rapidly evolving COVID-19 situation. Ann Intensive Care Features, Evaluation and Treatment Coronavirus (COVID-19) Clinical guide for the management of critical care patients during the coronavirus pandemic An official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine clinical practice guideline: mechanical ventilation in adult patients with acute respiratory distress syndrome Lung recruitability in SARS-CoV-2 associated acute respiratory distress syndrome: a single-center, observational study Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury FDA advises patients on use of non-steroidal antiinflammatory drugs (NSAIDs) for COVID-19 Ibuprofen use and Coronavirus (COVID-19) Clinical management of persons admitted to hospital with suspected COVID-19 infection Godzilla in the corridor: The Ontario SARS crisis in historical perspective. keywords: care; covid-19; critical; disease; intensive; need; patients; risk; services; support; use cache: cord-279396-qmixem8i.txt plain text: cord-279396-qmixem8i.txt item: #1210 of 2876 id: cord-279435-ffgd2ets author: ALBalawi, Hani B title: COVID-19: Precautionary Guidelines for Ophthalmologists date: 2020-06-25 words: 3188 flesch: 46 summary: Highrisk or COVID-19 positive patients with urgent ophthalmic problems can be seen but after following local hospital guidelines and precautions for treating patients with COVID-19 or that of the Centers for Disease Control and Prevention (CDC) such as using an N95 mask, eye protection, and gowns ( Figure 1 ) In 99 patients with COVID-19 virus infection, chest pain, confusion, and nausea-vomiting were noted in addition to previous findings [15] . keywords: contact; coronavirus; covid-19; health; human; infection; ophthalmologists; patients; risk cache: cord-279435-ffgd2ets.txt plain text: cord-279435-ffgd2ets.txt item: #1211 of 2876 id: cord-279456-oouylyx9 author: Henchi, Sonia title: First COVID-19 sub-intensive respiratory unit in Europe: the Italian experience date: 2020-06-23 words: 1504 flesch: 42 summary: In UTISIR were admitted patients testing positive to SARS-CoV-2 throat swab with phenotype 3,4,5, ICU patients weaned from intubation, with tracheostomy and transferred from other low-intensity care departments of the hospital, when appropriated. In this paper, we describe how the first Sub-intensive Respiratory Unit in Europe completely dedicated to COVID-19 patients was organized and managed in our hospital. keywords: covid-19; cpap; icu; patients; unit; utisir cache: cord-279456-oouylyx9.txt plain text: cord-279456-oouylyx9.txt item: #1212 of 2876 id: cord-279480-nqp1pc9v author: Ring, Laurence E. title: What Obstetricians should know about Obstetric Anesthesia during the COVID-19 pandemic date: 2020-08-26 words: 2785 flesch: 31 summary: A randomized trial of phenylephrine infusion versus bolus dosing for nausea and vomiting during Cesarean delivery in obese women Antiemetics added to phenylephrine infusion during cesarean delivery: a randomized controlled trial Spinal-induced hypotension: Incidence, mechanisms, prophylaxis, and management: Summarizing 20 years of research Uterine Exteriorization Compared With In Situ Repair of Hysterotomy After Cesarean Delivery: A Randomized Controlled Trial Uterine exteriorization compared with in situ repair for Cesarean delivery: a systematic review and meta-analysis Compared to standard care in noninfected patients, the anesthesiologist may be more likely to replace a questionably functional epidural catheter in COVID-19 infected patients, in hopes to avoid urgent situations that may increase the odds for patient adverse outcomes (e.g. accidental dural puncture during a replacement of epidural catheter, or general anesthesia if urgent cesarean delivery) or avoidable exposures for healthcare providers (rushed replacement of neuraxial analgesia/anesthesia or general anesthesia in the operating room). keywords: analgesia; anesthesia; cesarean; covid-19; delivery; labor; neuraxial cache: cord-279480-nqp1pc9v.txt plain text: cord-279480-nqp1pc9v.txt item: #1213 of 2876 id: cord-279483-gwikyux2 author: Wong, Joshua Guoxian title: Risk prediction models to guide antibiotic prescribing: a study on adult patients with uncomplicated upper respiratory tract infections in an emergency department date: 2020-11-02 words: 4301 flesch: 40 summary: Cochrane Database of Syst Rev Over-prescribing of antibiotics and imaging in the management of uncomplicated URIs in emergency departments Trends in emergency department antibiotic prescribing for acute respiratory tract infections Ambulatory antibiotic prescribing for acute bronchitis and cough and hospital admissions for respiratory infections: time trends analysis Antibiotic use for viral acute respiratory tract infections remains common Antibiotic utilization for acute respiratory tract infections in U.S. emergency departments Predictors of frequent attenders of emergency department at an acute general hospital in Singapore Frequent attenders at the emergency department: an analysis of characteristics and utilisation trends. Furthermore, most studies on antibiotic prescribing focus on understanding behaviors and perceptions or finding associative factors for antibiotic prescribing decisions [22] [23] [24] [25] . keywords: antibiotics; data; infections; influenza; models; patients; prescribing; study cache: cord-279483-gwikyux2.txt plain text: cord-279483-gwikyux2.txt item: #1214 of 2876 id: cord-279513-m4jdc8ua author: Onesti, Concetta Elisa title: Oncological care organisation during COVID-19 outbreak date: 2020-08-26 words: 4161 flesch: 41 summary: A novel coronavirus from patients with pneumonia in China Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding The proximal origin of SARS-CoV-2 COVID-19 data Repository by the center for systems science and engineering (CSSE) at Johns Hopkins University SARS-CoV-2 transmission in patients with cancer at a tertiary care hospital in Wuhan, China Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Case-Fatality rate and characteristics of patients dying in relation to COVID-19 in Italy European Centre for Disease Prevention and Control -Covid-19 pandemic Cancer care during the spread of coronavirus disease 2019 (COVID-19) in Italy: young oncologists' perspective Radiation therapy during the coronavirus disease 2019 (covid-19) pandemic in Italy: a view of the nation's young oncologists COVID19 Prevention & Care A Cancer Specific Guideline Cancer Care Delivery Challenges Amidst Coronavirus Disease -19 (COVID-19) Outbreak: Specific Precautions for Cancer Patients and Cancer Care Providers to Prevent Spread Practice recommendations for risk-adapted head and neck cancer radiation therapy during the COVID-19 pandemic: an ASTRO-ESTRO consensus statement Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: an ESTRO-ASTRO consensus statement Management of lung nodules and lung cancer screening during the COVID-19 pandemic: chest expert panel report Neuro-Oncology management during the COVID-19 pandemic with a focus on who grade III and IV gliomas A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international Collaborative group Managing COVID-19 in the oncology clinic and avoiding the distraction effect Summary of international recommendations in 23 languages for patients with cancer during the COVID-19 pandemic Active and effective measures for the care of patients with cancer during the COVID-19 spread in China Incorporating telemedicine as part of COVID-19 outbreak response systems Dynamic profile of RT-PCR findings from 301 COVID-19 patients in Wuhan, China: a descriptive study SARS-CoV-2 viral load in upper respiratory specimens of infected patients Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens Sensitivity of chest CT for COVID-19: comparison to RT-PCR Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR Correlation of chest CT and RT-PCR testing for coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Performance of VivaDiag COVID-19 IgM/IgG rapid test is inadequate for diagnosis of COVID-19 in acute patients referring to emergency room department Antibody responses to SARS-CoV-2 in patients with COVID-19 Lower detection rates of SARS-COV2 antibodies in cancer patients versus health care workers after symptomatic COVID-19 Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Viral dynamics in mild and severe cases of COVID-19 Call for ensuring cancer care continuity during COVID-19 pandemic Provenance and peer review Not commissioned; externally peer reviewed. This, however, has often resulted in a lack of resources for routine patient care. keywords: cancer; care; cases; centres; covid-19; hospital; pandemic; patients; risk cache: cord-279513-m4jdc8ua.txt plain text: cord-279513-m4jdc8ua.txt item: #1215 of 2876 id: cord-279550-7u2hksxm author: Wang, Kai title: Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection date: 2020-08-03 words: 2671 flesch: 47 summary: Moreover, a SARS-CoV A c c e p t e d M a n u s c r i p t 14 antigen-specific memory B cell response was not detectable in recovered SARS patients at 6-years after disease onset, whereas SARS-CoV-specific memory T cells persisted in recovered SARS patients. NAb titers increased over time in parallel with the rise in IgG antibody levels, correlating well at week 3 (r = 0·41, p & 0·05). keywords: cov-2; covid-19; levels; nab; nabs; patients; sars cache: cord-279550-7u2hksxm.txt plain text: cord-279550-7u2hksxm.txt item: #1216 of 2876 id: cord-279557-hk77e3pp author: Drosten, Christian title: Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection date: 2013-06-17 words: 4220 flesch: 51 summary: The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. We report data for a patient who was admitted to the Klinikum Schwabing (Munich, Germany) for severe acute respiratory infection. keywords: coronavirus; cov; data; day; infection; mers; patient; respiratory; samples; virus cache: cord-279557-hk77e3pp.txt plain text: cord-279557-hk77e3pp.txt item: #1217 of 2876 id: cord-279570-lgbqpfh5 author: Fragkou, Paraskevi C. title: Clinical characteristics and outcomes of measles outbreak in adults: a multicenter retrospective observational study of 93 hospitalized adults in Greece date: 2020-08-26 words: 2748 flesch: 42 summary: 2019 global summary National Update on Measles Cases and Outbreaks -United States Ongoing measles outbreak in Greece related to the recent European-wide epidemic The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection -on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions Investigators, Adult patients hospitalized for measles in France, in the 21st century Clinical and laboratory features of measles in hospitalized adults Measles-related hospitalizations and associated complications in Jerusalem Cocirculation of genotypes D4 and D6 in Greece during the 2005 to 2006 measles epidemic Epidemiological, clinical and laboratory characteristics of the measles resurgence in the Republic of Serbia Clinical and immunological analysis of measles patients admitted to a Beijing hospital in 2014 during an outbreak in China Impact and longevity of measles-associated immune suppression: a matched cohort study using data from the THIN general practice database in the UK Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles C-reactive protein as a biomarker of severe H1N1 influenza C-Reactive Protein and Respiratory Viral Infection The course of Creactive protein response in untreated upper respiratory tract infection Changes in serum C-reactive protein during complicated and uncomplicated measles virus infections Bacterial pneumonia as a suprainfection in young adults with measles Severe measles pneumonia in adults with respiratory failure: role of ribavirin and high-dose vitamin A Severe measles pneumonitis in adults: evaluation of clinical characteristics and therapy with intravenous ribavirin Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection H1N1-Induced Venous Thromboembolic Events? In this study we aim to describe the clinical characteristics and complications of measles infection in hospitalized adults during the recent epidemic in Greece keywords: adults; infection; measles; patients; pneumonitis; study cache: cord-279570-lgbqpfh5.txt plain text: cord-279570-lgbqpfh5.txt item: #1218 of 2876 id: cord-279571-chiadufa author: Cui, Xiaoyang title: Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study date: 2020-07-24 words: 3931 flesch: 50 summary: Our findings show that admission SOFA score was an independent risk factor for AKI in COVID-19 patients, and patients with AKI had higher in-hospital mortality. The clinical symptoms of COVID-19 patients include fever, cough, and fatigue, and a small population of patients exhibit gastrointestinal symptoms. keywords: admission; aki; covid-19; early; fluid; late; patients; study cache: cord-279571-chiadufa.txt plain text: cord-279571-chiadufa.txt item: #1219 of 2876 id: cord-279667-ikfduu2k author: Ronnje, Louise title: Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery date: 2020-09-04 words: 3366 flesch: 45 summary: [19] found that elevated levels of IL-6 were associated with a significantly increased risk of mortality in COVID-19 patients but in this case the inflammatory markers (and liver enzyme tests) decreased significantly after the Caesarean section. Atypical presentation of HELLP could not be ruled out and the importance of a multidisciplinary team in the treatment and management of severe COVID-19 during pregnancy is critical for positive patient outcome. keywords: case; clinical; coronavirus; covid-19; day; infection; liver; patient; pregnancy cache: cord-279667-ikfduu2k.txt plain text: cord-279667-ikfduu2k.txt item: #1220 of 2876 id: cord-279719-z0wuajpx author: Martin-Fumadó, Carles title: Medico-legal and ethical considerations on resource limitation and clinical decisions during the COVID-19 pandemic date: 2020-07-15 words: 4958 flesch: 37 summary: 12 Over and above specific scenarios, such as the emergency department, healthcare systems always set priorities in medical care, and this involves macroassignation processes as well as the microassignation of medical resources. Determining the scopes and limits of what it is fair to demand depends on the way in which the right to medical care is defined and specified, together with the creation of criteria for the distribution of medical resources. keywords: care; covid-19; decision; justice; making; pandemic; patients; rationing; resources cache: cord-279719-z0wuajpx.txt plain text: cord-279719-z0wuajpx.txt item: #1221 of 2876 id: cord-279732-cea0nt8z author: Bentley, Suzanne K. title: Guidance and Patient Instructions for Proning and Repositioning of Awake, Non‐Intubated COVID‐19 Patients date: 2020-06-29 words: 964 flesch: 23 summary: Prior studies on proning awake, non-intubated patients with hypoxemic acute respiratory failure, 1,2 as well as evolving study of similar COVID-19 patients, [3] [4] [5] [6] coupled with experience and dramatic anecdotal evidence from the COVID-19 pandemic, suggest the importance of proning all such patients with COVID-19 to improve oxygenation and reduce respiratory effort. Mild COVID-19 patients often still have respiratory involvement that may benefit from these exercises. keywords: hours; patients; proning cache: cord-279732-cea0nt8z.txt plain text: cord-279732-cea0nt8z.txt item: #1222 of 2876 id: cord-279736-udsbcqfs author: Abdalkader, Mohamad title: Roadmap for Resuming Elective Neuroendovascular Procedures Following the First COVID-19 Surge date: 2020-07-27 words: 1888 flesch: 21 summary: key: cord-279736-udsbcqfs authors: Abdalkader, Mohamad; Sathya, Anvitha; Malek, Adel M.; Fifi, Johanna T.; Norbash, Alexander M.; Wakhloo, Ajay K.; Nguyen, Thanh N. title: Roadmap for Resuming Elective Neuroendovascular Procedures Following the First COVID-19 Surge date: 2020-07-27 journal: J Stroke Cerebrovasc Dis DOI: 10.1016/j.jstrokecerebrovasdis.2020.105177 sha: doc_id: 279736 cord_uid: udsbcqfs The COVID-19 pandemic led to prioritizing high-acuity care of COVID-19 patients, while deferring non-emergent neurointerventional procedures worldwide in order to both limit contagion and add capacity for the anticipated COVID-19 surge. More specifically, health care resources, health care workers, and personal protective equipment (PPE) were all reorganized to ensure availability for the anticipated care of COVID-19 patients. keywords: care; covid-19; patients; procedure; risk cache: cord-279736-udsbcqfs.txt plain text: cord-279736-udsbcqfs.txt item: #1223 of 2876 id: cord-279790-zzvetjrt author: Zeng, Liujun title: Strategic plan for management in oral and maxillofacial surgery during COVID-19 epidemic date: 2020-04-11 words: 992 flesch: 43 summary: [3] , and accordingly we can conduct preliminary screening of surgical patients. Oral and maxillofacial surgery generally involves the upper respiratory tract, and the surgical site is often contaminated by saliva, so when the electrosurgical equipment is used, powerful suction should be applied to reduce the diffusion of surgical smoke and aerosols. keywords: coronavirus; patients; virus cache: cord-279790-zzvetjrt.txt plain text: cord-279790-zzvetjrt.txt item: #1224 of 2876 id: cord-279846-g0ro8pbb author: Terrigno, Vittorio R title: Right Atrial Thrombus in a Patient With COVID-19 date: 2020-07-28 words: 1058 flesch: 42 summary: This may be beneficial in patients with COVID-19 who require prone positioning and frequent neurological checks as well as for COVID-19 patients who are at higher risk when receiving thrombolytic therapy. Due to hospital protocol during the COVID-19 pandemic and the family's wish, Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Incidence of thrombotic complications in critically ill ICU patients with COVID-19 COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC State-ofthe-Art Review In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. keywords: anticoagulation; covid-19; patients cache: cord-279846-g0ro8pbb.txt plain text: cord-279846-g0ro8pbb.txt item: #1225 of 2876 id: cord-280005-i9fp5rys author: Wang, Mengmei title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date: 2020-09-21 words: 3192 flesch: 42 summary: key: cord-280005-i9fp5rys authors: Wang, Mengmei; Zhao, Yang; Hu, Weihua; Zhao, Dong; Zhang, Yunting; Wang, Tao; Zheng, Zhishui; Li, Xiaochen; Zeng, Shaolin; Liu, Zhenlian; Lu, Li; Wan, Zhihui; Hu, Ke title: Treatment of COVID-19 Patients with Prolonged Post-Symptomatic Viral Shedding with Leflunomide -- a Single-Center, Randomized, Controlled Clinical Trial date: 2020-09-21 journal: Clin Infect Dis DOI: 10.1093/cid/ciaa1417 sha: doc_id: 280005 cord_uid: i9fp5rys OBJECTIVE: To evaluate the efficacy and safety of leflunomide, an approved dihydroorotate dehydrogenase inhibitor, to treat COVID-19 patients with prolonged post-symptomatic viral shedding. In COVID-19 patients with prolonged PCR positivity, no benefit in terms of the duration of viral shedding was observed with the combined treatment of leflunomide and IFN α-2a beyond IFN α-2a alone. keywords: covid-19; days; group; leflunomide; patients; shedding; treatment; trial cache: cord-280005-i9fp5rys.txt plain text: cord-280005-i9fp5rys.txt item: #1226 of 2876 id: cord-280030-neqycg6v author: Sewlall, Nivesh H. title: Clinical Features and Patient Management of Lujo Hemorrhagic Fever date: 2014-11-13 words: 6568 flesch: 46 summary: I. Clinical description and pathological findings A prospective study of the epidemiology and ecology of Lassa fever Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review An outbreak of Lassa fever on the Jos plateau Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice Lassa fever in France Ebola Hemorrhagic Fever: Novel Biomarker Correlates of Clinical Outcome 389: Viral Hemorrhagic Fevers Treatment of Marburg and Ebola hemorrhagic fevers: a strategy for testing new drugs and vaccines under outbreak conditions Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock Treatment of Bolivian hemorrhagic fever with intravenous ribavirin Brief report: treatment of a laboratory-acquired Sabia virus infection Treatment of Argentine hemorrhagic fever Review of the literature and proposed guidelines for the use of oral ribavirin as postexposure prophylaxis for Lassa fever Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review The effect of N-acetylcysteine on nuclear factor-kappa B activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor Efficacy and safety of recombinant factor VIIa for treatment of severe bleeding: a systematic review Low-dose recombinant factor VIIa for trauma patients with coagulopathy Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats Highvolume hemofiltration as salvage therapy in severe hyperdynamic septic shock Severe hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virus New opportunities for field research on the pathogenesis and treatment of Lassa fever Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations Some distinctive features of LHF relative to typical Lassa fever were the abrupt disease onset (typically indolent in Lassa fever) and the presence of DIC, which is generally not considered to be part of the pathogenesis of Lassa fever, although the matter has not been extensively studied [9] . keywords: arenavirus; cases; clinical; fever; hemorrhagic; infection; lassa; lujo; patient; rash; vhf; virus cache: cord-280030-neqycg6v.txt plain text: cord-280030-neqycg6v.txt item: #1227 of 2876 id: cord-280060-gzby85u9 author: Rello, Jordi title: Management of infections in critically ill returning travellers in the intensive care unit—II: clinical syndromes and special considerations in immunocompromised patients() date: 2016-04-28 words: 5495 flesch: 32 summary: Travel patterns and risk behavior in solid organ transplant recipients International travel patterns and travel risks for stem cell transplant recipients International travel in the immunocompromised patient: a cross-sectional survey of travel advice in 254 consecutive patients Symptoms of infectious diseases in immunocompromised travelers: a prospective study with matched controls Multidrug-resistant bacteria without borders: role of international trips in the spread of multidrug-resistant bacteria Infection in solid-organ transplant recipients Impact of antiviral preventive strategies on the incidence and outcomes of cytomegalovirus disease in solid organ transplant recipients Travel medicine and transplant tourism in solid organ transplantation Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register Tuberculosis associated with infliximab, a tumor necrosis factor alphaneutralizing agent Anti-tumour necrosis factor-induced visceral and cutaneous leishmaniasis: case report and review of the literature Bacterial infections in low-risk, febrile neutropenic patients Post-splenectomy and hyposplenic states Such patients may be instructed to start empirical antibiotics targeted at encapsulated bacteria immediately if any clinical signs or symptoms of infection ensue. keywords: disease; fever; haemorrhagic; infections; malaria; organ; patients; pneumonia; recipients; risk; therapy; transplant; travel; travellers cache: cord-280060-gzby85u9.txt plain text: cord-280060-gzby85u9.txt item: #1228 of 2876 id: cord-280070-c1bkhgaz author: Azadeh, Natalya title: The Role of Infection in Interstitial Lung Diseases A Review date: 2017-10-31 words: 6531 flesch: 34 summary: Sarcoidosis Vasc Diffuse Lung Dis Sarcoidosis: in search of the cause Evidence for mycobacteria in sarcoidosis Etiology of sarcoidosis: does infection play a role? Immunolocalization of cell-wall-deficient forms of Mycobacterium tuberculosis complex in sarcoidosis and in sinus histiocytosis of lymph nodes draining carcinoma Molecular evidence for the role of mycobacteria in sarcoidosis: a meta-analysis High prevalence of Mycobacterium tuberculosis DNA in biopsies from sarcoidosis patients from Catalonia Quantitative analysis of mycobacterial and propionibacterial DNA in lymph nodes of Japanese and European patients with sarcoidosis Is there any association between sarcoidosis and infectious agents? Infectious causes need to be considered in the diagnostic evaluation of patients with suspected IIP, since the histopathologic patterns of lung injury underlying some IIPs can also be seen in pulmonary infections (Table 1) . keywords: acute; fibrosis; ild; infection; interstitial; ipf; lung; patients; pneumonia; pulmonary; role cache: cord-280070-c1bkhgaz.txt plain text: cord-280070-c1bkhgaz.txt item: #1229 of 2876 id: cord-280097-f7ky61ds author: Zarogoulidis, Paul title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? date: 2011-01-07 words: 3170 flesch: 51 summary: Patients with positive flu test were transferred in an 8 bed unit with negative pressure especially designed to quarantine and isolate patients with airborne transmitted viral infections. We were unable to explain the reason that the majority of H1N1 patients were not obese in our study as in previous reported studies [9, 25] . keywords: group; h1n1; influenza; mean; negative; patients cache: cord-280097-f7ky61ds.txt plain text: cord-280097-f7ky61ds.txt item: #1230 of 2876 id: cord-280111-6hiuzkvz author: Maspero, Cinzia title: Available Technologies, Applications and Benefits of Teleorthodontics. A Literature Review and Possible Applications during the COVID-19 Pandemic date: 2020-06-17 words: 6917 flesch: 41 summary: Indeed, an application for smartphones that allows remote monitoring of orthodontic patients using an algorithm of artificial intelligence, has recently been developed. The Italian Society of Orthodontics (SIDO) has recently published the recommended guidelines on the management of orthodontic patients during the COVID-19 outbreak. keywords: management; monitoring; office; patients; review; studies; study; teleassistance; teleorthodontics; time; treatment; visits cache: cord-280111-6hiuzkvz.txt plain text: cord-280111-6hiuzkvz.txt item: #1231 of 2876 id: cord-280129-a97rvtzl author: Honore, Patrick M. title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date: 2020-06-16 words: 555 flesch: 40 summary: In our large cohort of COVID-19 patients, we had several patients who did not regain consciousness as expected, even when sedation had been stopped for 4-5 days. key: cord-280129-a97rvtzl authors: Honore, Patrick M.; Barreto Gutierrez, Leonel; Kugener, Luc; Redant, Sebastien; Attou, Rachid; Gallerani, Andrea; De Bels, David title: Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation date: 2020-06-16 journal: Crit Care DOI: 10.1186/s13054-020-03088-x sha: doc_id: 280129 cord_uid: a97rvtzl nan Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation Patrick M. Honore * , Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels We read with great interest the recent research letter by Cardoso et al. who describe the liver injury seen with COVID-19 keywords: liver; patients cache: cord-280129-a97rvtzl.txt plain text: cord-280129-a97rvtzl.txt item: #1232 of 2876 id: cord-280233-avmisu31 author: Chase, J. Geoffrey title: Safe doubling of ventilator capacity: a last resort proposal for last resorts date: 2020-05-14 words: 1644 flesch: 50 summary: In-parallel is a critical point, as inspiration and expiration all take place at the same time, so there is thus no change to respiratory rate (RR) and tidal volume or driving pressure are adjusted for the number of patients. In-series breathing means only 1 circuit volume (split between patients) is active at a time, but each patient's inspiratory effort is singular. keywords: patients; pressure; ventilator; volume cache: cord-280233-avmisu31.txt plain text: cord-280233-avmisu31.txt item: #1233 of 2876 id: cord-280241-h16s6wwm author: McStay, R. title: COVID-19: looking beyond the peak. Challenges and tips for radiologists in follow-up of a novel patient cohort date: 2020-10-08 words: 4860 flesch: 27 summary: Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) Association of cardiac injury with mortality in hospitalised patients with COVID-19 in Wuhan, China Neurological manifestations of hospitalised patients with COVID-19 in Wuhan, China: a retrospective case series study Myocardial injury and COVID-19: possible mechanisms Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical characteristics of 138 hospitalised patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China The variety of cardiovascular presentations of COVID-19 Myocarditis revealing COVID-19 infection in a young patient COVID-19 and cardiovascular disease Cardiac involvement in recovered COVID-19 patients identified by magnetic resonance imaging SARS-CoV-2-induced Kawasaki-like hyperinflammatory syndrome: a novel COVID phenotype in children COVID-19 and Kawasaki disease: novel virus and novel case COVID-19 and Kawasaki disease: finding the signal in the noise Kidney disease is associated with in-hospital death of patients with COVID-19 Gastrointestinal and liver manifestations in patients with COVID-19 Liver injury during highly pathogenic human coronavirus infections Neurological manifestations and complications of COVID-19: a literature review Posterior reversible encephalopathy syndrome (PRES) as a neurological association in severe COVID-19 Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: case report COVID-19 infection and circulation ACE2 levels: protective role in women and children. It would seem reasonable, therefore, to suggest that although patients may develop acute PE secondary to a severe illness and hospitalisation, the pronounced inflammatory response seen in a cohort of COVID-19 patients results in a substantial pro-thrombotic tendency. keywords: acute; covid-19; disease; follow; imaging; lung; patients; pneumonia cache: cord-280241-h16s6wwm.txt plain text: cord-280241-h16s6wwm.txt item: #1234 of 2876 id: cord-280278-gq1hnnwh author: Chi, Meng title: A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date: 2020-06-08 words: 808 flesch: 44 summary: Our appliance reduces the spread of droplets and aerosols from patients, blocking the airborne transmission route of the virus to a large extent and providing a new layer of protection for health care workers during advanced airway management. key: cord-280278-gq1hnnwh authors: Chi, Meng; Lou, Changming; Zhao, Xiuli; Sui, Xin; Han, Fei title: A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management date: 2020-06-08 journal: Crit Care DOI: 10.1186/s13054-020-02985-5 sha: doc_id: 280278 cord_uid: gq1hnnwh nan Health care workers are exposed to high-risk environments when patients infected with COVID-19 require advanced airway management. keywords: intubation; patient cache: cord-280278-gq1hnnwh.txt plain text: cord-280278-gq1hnnwh.txt item: #1235 of 2876 id: cord-280280-9jr7ekbu author: Bertoncelli, Deborah title: COVID19: potential cardiovascular issues in pediatric patients date: 2020-05-11 words: 3395 flesch: 20 summary: Children do not seem to count for a large proportion of COVID-19 disease infections. According to a morbidity/mortality report by the Centers for Disease Control of the United States, among the pediatric cases with information on underlying conditions, the most common underlying condition after chronic lung disease was cardiovascular disease (58, 59) . keywords: acute; children; coronavirus; cov-2; covid-19; disease; infection; patients; sars cache: cord-280280-9jr7ekbu.txt plain text: cord-280280-9jr7ekbu.txt item: #1236 of 2876 id: cord-280348-vrnxucye author: Argano, Christiano title: Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry date: 2020-07-27 words: 4677 flesch: 31 summary: In this observational study on the RePoSI registry, we assessed the distribution of comorbidities and the occurrence of outcomes in a population of elderly COPD in-patients admitted to the internal medicine and geriatric wards, with the aim to evaluate whether COPD subjects behave differently from non-COPD individuals. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. keywords: analysis; comorbidities; copd; data; disease; hospital; mortality; patients; study; subjects; year cache: cord-280348-vrnxucye.txt plain text: cord-280348-vrnxucye.txt item: #1237 of 2876 id: cord-280358-ru2hv6pz author: Auvinen, R. title: Comparison of the clinical characteristics and outcomes of hospitalized adult COVID-19 and influenza patients: a prospective observational study date: 2020-06-29 words: 4223 flesch: 46 summary: COVID-19 patients were hospitalized longer than influenza patients (6 days COVID-19 patients were hospitalized on average on day 10 of symptoms compared with day 3 for influenza patients ( Table 2 ). keywords: author; covid-19; funder; influenza; medrxiv; patients; perpetuity; preprint; study cache: cord-280358-ru2hv6pz.txt plain text: cord-280358-ru2hv6pz.txt item: #1238 of 2876 id: cord-280360-rh37d5wc author: Gibson, David S. title: Comparative analysis of synovial fluid and plasma proteomes in juvenile arthritis – Proteomic patterns of joint inflammation in early stage disease date: 2009-05-02 words: 8306 flesch: 38 summary: The group of selected synovial fluid proteins fell within~10 to 100 KDa molecular weight range. This study is concerned with revealing protein markers to allow us to not only track the process of inflammation in detail, but more importantly to dissecting out synovial protein expression patterns which may identify more reliable predictors of JIA outcome. keywords: analysis; arthritis; disease; expression; fluid; gel; inflammation; jia; joint; levels; patients; plasma; proteins; proteome; spots; study; synovial cache: cord-280360-rh37d5wc.txt plain text: cord-280360-rh37d5wc.txt item: #1239 of 2876 id: cord-280431-tuzdng4h author: Alinier, Guillaume title: 5 Basing a Nonclinician's Career upon Simulation The Personal Experience of a Physicist date: 2008-12-31 words: 3509 flesch: 37 summary: This chapter concerns the breed of people who start by selecting a nonclinician path and eventually work in clinical simulation. There are many different opportunities and responsibilities in the domain of clinical simulation, and nonclinicians could occupy almost any one of them. keywords: care; center; health; new; patient; simulation; skills; training cache: cord-280431-tuzdng4h.txt plain text: cord-280431-tuzdng4h.txt item: #1240 of 2876 id: cord-280507-1nf2ycp3 author: Álvarez‐Román, MT title: Clinical trials and Haemophilia during the COVID‐19’ pandemic: Madrid’s Experience date: 2020-05-16 words: 1091 flesch: 42 summary: During this period, we have had close contact with patients, sometimes was proactive contact by the patient, and sometimes a proactive contact performed by the investigator team. Patients were referred to a doctor when necessary, either at the haemophilia treatment centre or at the emergency department. keywords: coronavirus; medication; patients; trials cache: cord-280507-1nf2ycp3.txt plain text: cord-280507-1nf2ycp3.txt item: #1241 of 2876 id: cord-280551-9hoxy5ok author: Kim, Donghee title: Predictors of Outcomes of COVID-19 in Patients with Chronic Liver Disease: US Multi-center Study date: 2020-09-17 words: 3589 flesch: 44 summary: Patients presenting with GI symptoms of diarrhea (OR 1.89, 95% CI: 1.30-2.74) or nausea/vomiting (OR 1.84, 95% CI: 1.27-2.68) were more likely to have severe COVID-19 than patients without GI symptoms (Table 2) . J o u r n a l P r e -p r o o f Trends in the Burden of Chronic Liver Disease Among Hospitalized US Adults The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study Burden of liver diseases in the world Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study Liver injury in COVID-19: management and challenges Clinical Features of COVID-19-Related Liver Damage Clinical Characteristics and Outcomes of COVID-19 Among Patients with Pre-Existing Liver Disease in United States: A Multi-Center Research Network Study High rates of 30-day mortality in patients with cirrhosis and COVID-19 High Mortality Rates for SARS-CoV-2 Infection in Patients with Pre-existing Chronic Liver Disease and Cirrhosis: keywords: cld; covid-19; disease; liver; mortality; patients cache: cord-280551-9hoxy5ok.txt plain text: cord-280551-9hoxy5ok.txt item: #1242 of 2876 id: cord-280554-9jp85yzz author: Lamure, Sylvain title: Determinants of outcome in Covid-19 hospitalized patients with lymphoma: A retrospective multicentric cohort study date: 2020-10-13 words: 4553 flesch: 43 summary: This encourages the application of standard Covid-19 treatment, including intubation, for lymphoma patients with Covid-19 lymphoma diagnosis, under firstor second-line chemotherapy, or in remission. Other limitations were the retrospective nature of the study and the study design, which did not allow a direct comparison between lymphoma patients with Covid-19 and Covid-19 patients without lymphoma. keywords: covid-19; fees; lymphoma; patients; refractory; study; treatment; years cache: cord-280554-9jp85yzz.txt plain text: cord-280554-9jp85yzz.txt item: #1243 of 2876 id: cord-280628-ok62havd author: Groß, Sonja title: SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications date: 2020-04-30 words: 4463 flesch: 34 summary: This, and the fact that SARS-CoV-2 hijacks ACE2 for cell-entry, have spurred controversial discussions on the role of ACE2 in COVID-19 patients. We further highlight currently investigated and upcoming therapy options for COVID-19 patients with cardiac disease conditions. launched to determine the presence of anti-SARS-CoV-2 antibodies. keywords: ace2; angiotensin; cardiac; coronavirus; covid-19; disease; infection; patients; receptor; sars; system cache: cord-280628-ok62havd.txt plain text: cord-280628-ok62havd.txt item: #1244 of 2876 id: cord-280794-k591vqji author: Bauer, Melissa E. title: Neuraxial Procedures in COVID-19–Positive Parturients: A Review of Current Reports date: 2020-04-20 words: 842 flesch: 31 summary: Before performing a neuraxial procedure in these patients, it would be advisable to review a recent platelet count given that one-third of patients with COVID-19 infection have been reported to have thrombocytopenia compared with 7%-12% of patients during pregnancy alone. Because anesthesiologists must take into account the risk of meningitis or encephalitis associated with neuraxial procedures in the setting of untreated viremia, we reviewed publications reporting outcomes in COVID-19-positive pregnant women in the current pandemic in an attempt to address this concern. keywords: covid-19; patients; procedures cache: cord-280794-k591vqji.txt plain text: cord-280794-k591vqji.txt item: #1245 of 2876 id: cord-280821-kc0ut4oy author: Venturini, Elisabetta title: Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease date: 2020-09-24 words: 5485 flesch: 38 summary: At present, few clinical trials for COVID-19 treatment involving children are ongoing [8] . Currently, American guidelines on COVID-19 treatment published in May 2020, recommend both in children and adults to use lopinavir/ritonavir only in the context of clinical trials, given the lack of effectiveness reported now in literature [9, 12] . keywords: children; cov-2; covid-19; days; hydroxychloroquine; infection; patients; sars; therapy; treatment; use cache: cord-280821-kc0ut4oy.txt plain text: cord-280821-kc0ut4oy.txt item: #1246 of 2876 id: cord-280848-z0sbztkw author: Setzen, Michael title: COVID-19 and rhinology: A look at the future date: 2020-04-15 words: 2883 flesch: 43 summary: COVID-19 patients harbor the virus in the nasopharynx; as a result, the Stanford Rhinology Division has recommended avoiding aerosolized sprays and instead using pledgets to mitigate this risk in the outpatient setting. Several changes have been implemented by CMS for Medicare patients that make it easier to perform telehealth visits in Otolaryngology. keywords: covid-19; endoscopy; office; patients; procedures; telemedicine; visits cache: cord-280848-z0sbztkw.txt plain text: cord-280848-z0sbztkw.txt item: #1247 of 2876 id: cord-280944-uphs5gvl author: Stagnell, S. title: COVID and consent date: 2020-07-10 words: 873 flesch: 45 summary: SDF has huge potential within community dentistry and general dental practices, more so at this unprecedented time. NO. 1 | JULy 10 2020 UPFRONT Implications of COVID-19 for the safe management of general dental practice -a practical guide keywords: consent; patients; use cache: cord-280944-uphs5gvl.txt plain text: cord-280944-uphs5gvl.txt item: #1248 of 2876 id: cord-280961-fka8c69p author: Zhang, Rui title: CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city date: 2020-04-11 words: 3670 flesch: 46 summary: Severe patients were 20 years older on average and had comorbidities and an elevated lactate dehydrogenase (LDH) level. These findings may help clinicians to identify severe patients quickly at admission. keywords: 2019; cases; coronavirus; disease; findings; patients; pneumonia; sars cache: cord-280961-fka8c69p.txt plain text: cord-280961-fka8c69p.txt item: #1249 of 2876 id: cord-280984-2j8ckz14 author: Roux, CH title: Impact of home confinement during the COVID‐19 pandemic on medication use and disease activity in spondyloarthritis patients date: 2020-06-17 words: 788 flesch: 37 summary: Efficacy of high intensity exercise on disease activity and cardiovascular risk in active axial spondyloarthritis: a randomized controlled pilot study COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? American College of Rheumatology Guidance for the Management of Adult Patients with Rheumatic Disease During the COVID-19 Pandemic American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis Predicting response to anti-TNFα therapy among patients with axial spondyloarthritis (axSpA): results from BSRBR-AS. We investigated the impact of confinement on the medication intake and disease activity in SpA patients in a questionnaire‐based survey. keywords: disease; patients cache: cord-280984-2j8ckz14.txt plain text: cord-280984-2j8ckz14.txt item: #1250 of 2876 id: cord-280996-anq680a1 author: Agarwal, Arnav title: High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission date: 2020-06-15 words: 7124 flesch: 34 summary: The effects of high-flow nasal cannula on intubation and re-intubation in critically ill patients: a systematic review, meta-analysis and trial sequential analysis The impact of high-flow nasal cannula on the outcome of immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis High flow nasal therapy in immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis Use high-flow nasal cannula for acute respiratory failure patients in the emergency department: a meta-analysis study Effect of high-flow nasal cannula oxygen therapy in immunocompromised subjects with acute respiratory failure High-flow nasal oxygen vs standard oxygen therapy in immunocompromised patients with acute respiratory failure: a meta-analysis of randomized controlled trials Efficacy of high-flow nasal cannula therapy in intensive care units: a meta-analysis of physiological and clinical outcomes High-flow nasal cannula versus conventional oxygen therapy in patients with dyspnea and hypoxemia before hospitalization a systematic review and metaanalysis The impact of high flow nasal oxygen in the immunocompromised critically ill: a systematic review and metaanalysis The impact of high-flow nasal oxygen in the immunocompromised critically ill: a systematic review and metaanalysis High flow nasal cannula oxygen vs. conventional oxygen therapy and non-invasive ventilation in emergency department patients: a systematic review and meta-analysis High-flow nasal cannula in adults with acute respiratory failure and after extubation: a systematic review and meta-analysis Non-invasive oxygenation strategies in immunocompromised patients with acute hypoxemic respiratory failure: a pairwise and network meta-analysis of randomized controlled trials Initial non-invasive oxygenation strategies in subjects with de novo acute hypoxemic respiratory failure Use of high-flow nasal cannula for immunocompromise and acute respiratory failure: a systematic review and meta-analysis High-flow nasal cannula: a promising oxygen therapy for patients with severe bronchial asthma complicated with respiratory failure Value and safety of high flow oxygenation in the treatment of inpatient asthma: a randomized, double-blind, pilot study High-flow nasal cannula versus conventional oxygen therapy in relieving dyspnea in emergency palliative patients with do-not-intubate status: a randomized crossover study High-flow nasal cannula versus conventional oxygen therapy in emergency department patients with cardiogenic pulmonary edema: a randomized controlled trial keywords: acute; aerosol; cannula; certainty; covid-19; dispersion; failure; flow; hfnc; nasal; oxygen; patients; review; studies; therapy; ventilation cache: cord-280996-anq680a1.txt plain text: cord-280996-anq680a1.txt item: #1251 of 2876 id: cord-281003-7pdhxdzc author: Farmakis, Dimitrios title: COVID‐19 and thalassaemia: A position statement of the Thalassaemia International Federation date: 2020-07-13 words: 2839 flesch: 37 summary: The haemoglobinopathy units and clinics are thus advised to designate a dedicated room within the medical facility that will be used to provide medical care to thalassaemia patients who are suspected or confirmed COVID-19 patients. On the other hand, therapeutic advances of the past decades have resulted in a significant improvement in the once ominous prognosis of thalassaemia patients, and thus, patients with access to modern treatment modalities and well-organized follow-up programmes grow old and face a new spectrum of comorbidities related to ageing. keywords: blood; care; coronavirus; covid-19; disease; pandemic; patients; thalassaemia cache: cord-281003-7pdhxdzc.txt plain text: cord-281003-7pdhxdzc.txt item: #1252 of 2876 id: cord-281039-a7q5nzwn author: Rodilla, Enrique title: Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 date: 2020-09-28 words: 4808 flesch: 41 summary: Second, previous treatment with ACEIs/ARBs in hypertensive patients was not associated with a higher risk of all-cause mortality in hypertensive hospitalized COVID-19 patients compared to other antihypertensive drugs. Furthermore, the causal role of age in explaining coronary heart disease and stroke increases in parallel with age [17] . Treatment of HT with renin-angiotensin-aldosterone system (RAAS) inhibitors might have a beneficial effect on COVID-19 patients. keywords: aceis; age; angiotensin; arbs; cause; covid-19; group; mortality; patients; treatment cache: cord-281039-a7q5nzwn.txt plain text: cord-281039-a7q5nzwn.txt item: #1253 of 2876 id: cord-281060-1ud5hzlh author: Méndez Maestro, Irune title: Skin manifestations in patients hospitalized with confirmed COVID‐19 disease: a cross‐sectional study in a tertiary hospital date: 2020-09-24 words: 1589 flesch: 42 summary: 2, 3 It was not until March 26 that Recalcati's article 4 analyzed skin manifestations in COVID-19 patients for the first time. The objective of this study was to examine the skin of hospitalized patients with a confirmed diagnosis of COVID‐19 disease and describe the real prevalence of skin manifestations. keywords: covid-19; disease; manifestations; patients cache: cord-281060-1ud5hzlh.txt plain text: cord-281060-1ud5hzlh.txt item: #1254 of 2876 id: cord-281064-b69p44uq author: Ozder, Aclan title: A Novel Indicator Predicts 2019 Novel Coronavirus Infection in Subjects with Diabetes date: 2020-07-03 words: 3500 flesch: 46 summary: This study aimed to evaluate the diagnostic role of MPV in Covid patients with diabetes. We have retrospectively analyzed the MPV values of age-and sex-matched 160 laboratory confirmed Covid patients without diabetes admitted to the Covid out-patient clinic. keywords: covid; diabetes; infection; mean; mpv; patients; platelet cache: cord-281064-b69p44uq.txt plain text: cord-281064-b69p44uq.txt item: #1255 of 2876 id: cord-281106-vzb5xzza author: Zerwes, S. title: COVID-19-Infektion – Risiko für thrombembolische Komplikationen date: 2020-09-01 words: 1943 flesch: 29 summary: The aim of the present review article is to summarize the most relevant vascular complications in COVID-19 patients. With a rate of approximately 20%, deep vein thrombosis (DVT) of the leg is one of the most common thromboembolic events in COVID-19 patients requiring intensive care treatment. keywords: bei; cov-2; covid-19; der; die; eine; mit; nicht; patients; sars; syndrome; thrombosis; und; von cache: cord-281106-vzb5xzza.txt plain text: cord-281106-vzb5xzza.txt item: #1256 of 2876 id: cord-281130-9tawihti author: Schirinzi, Annalisa title: Pentraxin 3: Potential prognostic role in SARS-CoV-2 patients admitted to the emergency department date: 2020-11-02 words: 1037 flesch: 31 summary: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Biomarker associated with COVID-19 disease progression Presepsin in risk stratification of SARS-CoV-2 patients Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients Multimer formation and ligand recognition by the long pentraxin PTX3: similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component Cellspecific regulation of PTX3 by glucocorticoid hormones in hematopoietic and nonhematopoietic cells Plasma long pentraxin 3 (PTX3) concentration is a novel marker of disease activity in patients with communityacquired pneumonia Laboratory abnormalities in patients with COVID-2019 infection Taste and Smell Disorders in COVID-19 In patients with community-acquired pneumonia (CAP), the plasma concentration of PTX3, but not CRP, was correlated with the severity of CAP based on the pneumonia severity index (PSI), CURB-65, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, and the length of hospital stay (7) . keywords: crp; patients; ptx3 cache: cord-281130-9tawihti.txt plain text: cord-281130-9tawihti.txt item: #1257 of 2876 id: cord-281175-og3myz22 author: Tapper, Elliot B. title: The COVID-19 pandemic will have a long-lasting impact on the quality of cirrhosis care date: 2020-04-13 words: 2678 flesch: 38 summary: How will COVID-19 negatively impact quality care We are only beginning to understand the impact of the pandemic on care quality. In this article, we review how COVID-19 will impact cirrhosis care. keywords: care; cirrhosis; covid-19; pandemic; patients; quality; risk; telehealth cache: cord-281175-og3myz22.txt plain text: cord-281175-og3myz22.txt item: #1258 of 2876 id: cord-281276-rffp6qe2 author: Rhazi, Karima El title: Ethical issues related to the hydroxychloroquine treatment prescription for Covid-19 date: 2020-06-17 words: 3416 flesch: 43 summary: However, one could argue that the worldwide emergency, the rapid spread of the disease, and the high rates of disease mortality mainly at the beginning of the pandemic [9] , are sufficient reasons for prescribing this off-label treatment for covid-19 patients. To date, no drugs have demonstrated safety and efficacy in randomized controlled trials for patients with COVID-19. keywords: covid-19; drug; evidence; hydroxychloroquine; label; patients; treatment; use cache: cord-281276-rffp6qe2.txt plain text: cord-281276-rffp6qe2.txt item: #1259 of 2876 id: cord-281283-h6yai7sx author: Ma, Jun title: Emergency response strategy for containing COVID-19 within a psychiatric specialty hospital in the epicenter of the COVID-19 epidemic in China date: 2020-08-04 words: 2196 flesch: 32 summary: During this isolation period, patients are screened, confirmed patients are transferred to the ward for confirmed COVID-19 patients, suspected patients are transferred to the ward for suspected COVID-19 patients, and clean (uninfected) patients are treated in this ward. (2) A ward for suspected COVID-19 patients: this ward is used for patients with negative nucleic acid test results but with clinical and imaging manifestations similar to those of COVID-19 patients; secondary protections should be implemented. keywords: covid-19; hospital; outbreak; patients; ward cache: cord-281283-h6yai7sx.txt plain text: cord-281283-h6yai7sx.txt item: #1260 of 2876 id: cord-281298-qheq9lc8 author: Merks, Piotr title: The legal extension of the role of pharmacists in light of the COVID-19 global pandemic date: 2020-06-12 words: 2156 flesch: 43 summary: 8 During a time of pandemic pharmacists 54 should concentrate not only on reducing the possibility of virus spread but also on patients' 55 daily needs related to taking medicines. Exceptional renewal of chronic treatment by community pharmacists. keywords: covid-19; health; pandemic; patients; pharmacists; pharmacy; prescriptions cache: cord-281298-qheq9lc8.txt plain text: cord-281298-qheq9lc8.txt item: #1261 of 2876 id: cord-281332-5mddyv0n author: Wilson, Michael R. title: A novel cause of chronic viral meningoencephalitis: Cache Valley virus date: 2017-07-25 words: 4013 flesch: 36 summary: Reverse transcription polymerase chain reaction and immunohistochemistry subsequently confirmed the presence of Cache Valley virus in the brain biopsy tissue. Cache Valley virus, a mosquito‐borne orthobunyavirus, has only been identified in 3 immunocompetent North American patients with acute neuroinvasive disease. keywords: biopsy; brain; cache; chronic; csf; cvv; generation; meningoencephalitis; pathogen; patient; sequencing; valley; virus cache: cord-281332-5mddyv0n.txt plain text: cord-281332-5mddyv0n.txt item: #1262 of 2876 id: cord-281344-iswbgqqe author: Jonker, Leonie T. title: Perioperative telemonitoring of older adults with cancer: Can we connect them all? date: 2020-09-04 words: 3936 flesch: 33 summary: Although the increasing cancer incidence in older patients is widely recognised, older patients remain underrepresented in clinical cancer trials and eHealth studies. This is a retrospective analysis of a prospective cohort study with older patients (≥ 65 years) undergoing cancer-related surgery, who were identified for a perioperative telemonitoring study. keywords: cancer; data; hospital; non; participants; patients; study cache: cord-281344-iswbgqqe.txt plain text: cord-281344-iswbgqqe.txt item: #1263 of 2876 id: cord-281346-bjhdy8mg author: Palacios Cruz, M. title: COVID-19, a worldwide public health emergency() date: 2020-04-21 words: 3513 flesch: 45 summary: The WHO requests that national authorities report confirmed cases of novel coronavirus infection within 24 h of identifying them and provide the patients' minimum basic data set. The diagnosis of the disease has been reached based on virus-induced pneumonia based on the clinical symptoms observed in patients (similar to that of other respiratory viruses), to their history of exposure to other people with the virus, and the history of visits to areas affected. keywords: cases; china; coronavirus; disease; health; infection; ncov; novel; patients; sars cache: cord-281346-bjhdy8mg.txt plain text: cord-281346-bjhdy8mg.txt item: #1264 of 2876 id: cord-281391-0qkku2jd author: Miller-Handley, Hilary title: Treatment Options for COVID-19 in Patients with Reduced or Absent Kidney Function date: 2020-09-17 words: 4721 flesch: 41 summary: Janssen Medical Information Face Sheet The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Clinical Features of 69 Cases with Coronavirus Disease ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell-Induced Severe or Life-Threatening Cytokine Release Syndrome Effective treatment of severe COVID-19 patients with tocilizumab Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients ACTEMRA® (tocilizumab) injection, for intravenous or subcutaneous use JAK-inhibitors. Corticosteroids usage in COVID-19 was originally controversial, because some data in SARS patients found no difference between steroid usage and no steroid usage in clinical outcomes; although studies were small, and mostly non-randomized [40] . keywords: clinical; covid-19; disease; hydroxychloroquine; patients; sars; therapy; treatment; trials cache: cord-281391-0qkku2jd.txt plain text: cord-281391-0qkku2jd.txt item: #1265 of 2876 id: cord-281561-r10y2sgb author: Tiwari, Nidhi title: Novel β-Coronavirus (SARS-CoV-2): Current and Future Aspects of Pharmacological Treatments date: 2020-08-27 words: 6887 flesch: 34 summary: The drugs at present used in COVID-19 patients and ongoing clinical trials focusing on drug repurposing of various therapeutic classes of drug e.g. antiviral, anti-inflammatory and/or immunomodulatory drugs along with adjuvant/supportive care. From this review, our aim is to provide a basic overview about currently available drugsand drugs under clinical trial for COVID-19 patients. keywords: coronavirus; cov-2; covid-19; disease; drug; efficacy; et al; infection; novel; patients; safety; sars; studies; study; treatment cache: cord-281561-r10y2sgb.txt plain text: cord-281561-r10y2sgb.txt item: #1266 of 2876 id: cord-281566-6v5zfue6 author: Hamilos, Daniel L. title: Host-microbial interactions in patients with chronic rhinosinusitis date: 2013-11-28 words: 11737 flesch: 30 summary: The role of epithelial beta-defensins and cathelicidins in host defense of the lung Human beta-defensins and toll-like receptors in the upper airway Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3 Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin Fungal allergens induce cathelicidin LL-37 expression in chronic rhinosinusitis patients in a nasal explant model Human cathelicidin antimicrobial peptide is up-regulated in the eosinophilic mucus subgroup of chronic rhinosinusitis patients Structure and functions of endotoxin-binding peptides derived from CAP18 The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense PLUNC is a novel airway surfactant protein with anti-biofilm activity PLUNC: a multifunctional surfactant of the airways Reduced expression of antimicrobial PLUNC proteins in nasal polyp tissues of patients with chronic rhinosinusitis Expression and clinical significance of PLUNC protein in nasal polyp and chronic sinusitis tissue The new histologic classification of chronic rhinosinusitis Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray Antibody equivalent molecules of the innate immune system: parallels between innate and adaptive immune proteins Upregulation of surfactant protein A in chronic rhinosinusitis Expression and significance of surfactant A in nasal polyps of chronic rhinosinusitis Surfactant protein d expression in chronic rhinosinusitis patients and immune responses in vitro to Aspergillus and Alternaria in a nasal explant model Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood A population-based study of morbidity and mortality in mannose-binding lectin deficiency Increased serum complement component 3 and mannose-binding lectin levels in adult Chinese patients with chronic rhinosinusitis Serum amyloid A is an innate immune opsonin for Gram-negative bacteria Alterations in gene expression of complement components in chronic rhinosinusitis High nitric oxide production in human paranasal sinuses Nitric oxide and the paranasal sinuses Activation of the receptor induces production of NO and increases ciliary beat frequency in sinus epithelial cells. keywords: aureus; bacterial; biofilm; cells; chronic; crs; disease; epithelial; expression; fungal; human; infection; mucosal; nasal; patients; production; protein; receptor; rhinosinusitis; role; studies; study cache: cord-281566-6v5zfue6.txt plain text: cord-281566-6v5zfue6.txt item: #1267 of 2876 id: cord-281729-z321pebe author: Santos, Cláudia title: Pathophysiology of acute fibrinous and organizing pneumonia – Clinical and morphological spectra date: 2019-05-02 words: 3049 flesch: 31 summary: Although both diseases show similar clinical evolution, which led Travis to think that the AFOP pattern could represent a fibrinous variant of DAD, almost all patients with DAD require ventilation support whereas only 30% (5 patients) of first series of AFOP patients described needed it. The predominance of acute fibrin alveolar deposition pattern is helpful in raising AFOP differential diagnosis while organizing pneumonia pattern establishes a wider range of diagnosis that can go till solitary pulmonary nodule, remaining indefinite to suggest diagnosis. keywords: acute; afop; alveolar; fibrinous; organizing; patients; pattern; pneumonia cache: cord-281729-z321pebe.txt plain text: cord-281729-z321pebe.txt item: #1268 of 2876 id: cord-281733-bsq0ewac author: Veyseh, Maedeh title: Left gonadal vein thrombosis in a patient with COVID-19-associated coagulopathy date: 2020-09-07 words: 2468 flesch: 38 summary: 8 Concomitant VTE, a potential cause of unexplained deaths, has been frequently reported in COVID-19 cases. Our case emphasises the high risk of coagulopathy in COVID-19 cases, even without a severe systemic infection. keywords: case; covid-19; disease; patients; symptoms; thrombosis; vein cache: cord-281733-bsq0ewac.txt plain text: cord-281733-bsq0ewac.txt item: #1269 of 2876 id: cord-281752-64mrflcr author: Vespignani, Hervé title: Report of EEG Finding on Critically Ill Patients with COVID‐19 date: 2020-06-13 words: 2117 flesch: 42 summary: Unfortunately, unless patients have evidence of focal brain injury on examination, many hospitals are not performing routine MR imaging on COVID-19 patients, as this risks increased exposure and requires subsequent decontamination of the scanner. The reported onset of loss of consciousness or confusion and cognitive impairment in COVID-19 infected patients with EEGs revealing biphasic delta PDs may suggest an injury or localized brain defect attributed to encephalopathy related to a unique and acute CNS process. keywords: activity; brain; covid-19; delta; eeg; patient cache: cord-281752-64mrflcr.txt plain text: cord-281752-64mrflcr.txt item: #1270 of 2876 id: cord-281804-lhnw8jx5 author: Sonis, Jonathan D. title: Humanism in the Age of COVID-19: Renewing Focus on Communication and Compassion date: 2020-04-24 words: 1988 flesch: 29 summary: As many patients will be discharged despite ongoing symptoms and -as hospital capacity constraints grow -even potentially with evidence of moderate disease, post-discharge follow-up calls, in which a staff member contacts patients by phone following ED discharge, will continue to serve multiple purposes. While video and telephonic alternatives to bedside evaluation may facilitate communication with patients while maintaining physical separation to limit healthcare worker exposure and preserve PPE, these solutions may not be as effective in older patients, who commonly have hearing and visual impairment, challenges with manual dexterity due to arthritis, and cognitive impairment, all of which impede effective use of such technology. keywords: care; communication; compassion; covid-19; patients; staff cache: cord-281804-lhnw8jx5.txt plain text: cord-281804-lhnw8jx5.txt item: #1271 of 2876 id: cord-281887-b511bjdy author: Ribeiro, Reitan title: Perioperative Cancer Care in the Context of Limited Resources during the COVID-19 Pandemic: Brazilian Society of Surgical Oncology Recommendations date: 2020-09-26 words: 4744 flesch: 40 summary: The rational use of resources to reduce the risk of surgical cancer patients being operated on during the incubation period of a corona virus infection is important in this context. We present a protocol, focused on the patients’ outcomes, for safe and rational use of resources to reduce the risk of surgical cancer patients being operated on during the virus incubation period, in the context of areas with limited resources. Discussion. keywords: areas; cancer; covid-19; pandemic; patients; prevalence; resources; risk; screening; surgery; testing cache: cord-281887-b511bjdy.txt plain text: cord-281887-b511bjdy.txt item: #1272 of 2876 id: cord-281945-jvnjzjds author: Radnis, Caitlin title: Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia date: 2020-09-06 words: 2814 flesch: 38 summary: In this case series, we describe three cases of hypoxic brain injury seen on magnetic resonance imaging (MRI) in patients with hypoxemia secondary to COVID-19-related ARDS. The lack of severe observed hypoxemia in two of the cases suggests that unrecognized or asymptomatic hypoxemia may play a role in hypoxic brain injury related to COVID-19. keywords: acute; ards; brain; covid-19; hypoxemia; injury; patients cache: cord-281945-jvnjzjds.txt plain text: cord-281945-jvnjzjds.txt item: #1273 of 2876 id: cord-282021-m1lh7mzd author: El Shamy, Osama title: Telenephrology with Remote Peritoneal Dialysis Monitoring during Coronavirus Disease 19 date: 2020-04-28 words: 1571 flesch: 43 summary: For patients currently on PD, telemedicine and advances in remote PD monitoring have been paramount in managing PD patients remotely. The same holds true in Chicago, Illinois, a growing epicenter, where the Medical District Home Dialysis staff are calling PD patients 2-3 times per week. keywords: covid-19; dialysis; home; patients cache: cord-282021-m1lh7mzd.txt plain text: cord-282021-m1lh7mzd.txt item: #1274 of 2876 id: cord-282043-cs1oyohu author: Giustino, Gennaro title: Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar date: 2020-10-27 words: 1930 flesch: -10 summary: A survey by the European Society of Cardiology Fewer hospitalizations for acute cardiovascular conditions during the COVID-19 pandemic Dysregulation of immune response in patients with COVID-19 in Wuhan, China Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock Effects of TNFalpha on [Ca2þ]i and contractility in isolated adult rabbit ventricular myocytes Dysregulation of intracellular calcium transporters in animal models of sepsis-induced cardiomyopathy TNF alpha receptor expression in rat cardiac myocytes: TNF alpha inhibition of L-type Ca2þ current and Ca2þ transients Drug-induced mitochondrial dysfunction and cardiotoxicity Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 Echocardiographic findings in patients with COVID-19 with significant myocardial injury Echocardiographic findings in patients with COVID-19 pneumonia Spectrum of cardiac manifestations in COVID-19: a systematic echocardiographic study STsegment elevation in patients with Covid-19-a case series ST-elevation myocardial infarction in patients with COVID-19: clinical and angiographic outcomes Takotsubo cardiomyopathy in males with Covid-19 The variety of cardiovascular presentations of COVID-19 Fulminant COVID-19-related myocarditis in an infant Acute myocarditis associated with COVID-19 infection Myocarditis detected after COVID-19 recovery Diffuse myocardial inflammation in COVID-19 associated myocarditis detected by multiparametric cardiac magnetic resonance imaging Fulminant myocarditis due to COVID-19 Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19) COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC State-of-the-Art Review Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action Hypoxia downregulates protein S expression Severe arterial thrombosis associated with Covid-19 infection Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Cardiovascular adverse events in patients with cancer treated with bevacizumab: a meta-analysis of more than 20 000 patients Multifaceted effects of hydroxychloroquine in human disease Acute pulmonary embolism and COVID-19 pneumonia: a random association? retrospective study Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Risk of myocardial infarction and stroke after acute infection or vaccination Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Acute myocardial injury in patients hospitalized with COVID-19 infection: a review Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2 Host cell proteases: critical determinants of coronavirus tropism and pathogenesis The science underlying COVID-19: implications for the cardiovascular system SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS COVID-19-related myocarditis in a 21-year-old female patient Typical takotsubo syndrome triggered by SARS-CoV-2 infection Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) Myocardial localization of coronavirus in COVID-19 cardiogenic shock Detection of viral SARS-CoV-2 genomes and histopathological changes in endomyocardial biopsies. keywords: acute; coronavirus; covid-19; disease; infection; injury; patients cache: cord-282043-cs1oyohu.txt plain text: cord-282043-cs1oyohu.txt item: #1275 of 2876 id: cord-282097-a1pwq4fi author: Hoertel, N. title: Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study date: 2020-10-27 words: 4418 flesch: 36 summary: key: cord-282097-a1pwq4fi authors: Hoertel, N.; Sanchez, M.; Vernet, R.; Beeker, N.; Neuraz, A.; Alvarado, J.; Daniel, C.; Paris, N.; Gramfort, A.; Lemaitre, G.; Salamanca, E.; Bernaux, M.; Bellamine, A.; Burgun, A.; Limosin, F. title: Dexamethasone use and Mortality in Hospitalized Patients with Coronavirus Disease 2019: a Multicenter Retrospective Observational Study date: 2020-10-27 journal: nan DOI: 10.1101/2020.10.23.20218172 sha: doc_id: 282097 cord_uid: a1pwq4fi Objective: To examine the association between dexamethasone use and mortality among hospitalized patients for COVID-19. In this group of patients, there was a significant association between dexamethasone use and reduced mortality in both the crude, unadjusted analysis (hazard ratio (HR), 0.40; 95% CI, 0.18 to 0.87, p=0.021) and the adjusted multivariable analysis (HR, 0.46; 95% CI, 0.22 to 0.96, p=0.039). keywords: covid-19; dexamethasone; medrxiv; patients; preprint; support cache: cord-282097-a1pwq4fi.txt plain text: cord-282097-a1pwq4fi.txt item: #1276 of 2876 id: cord-282151-mai4eggf author: Bai, Lu title: Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date: 2015-12-16 words: 3765 flesch: 53 summary: key: cord-282151-mai4eggf authors: Bai, Lu; Gu, Li; Cao, Bin; Zhai, Xiao-Li; Lu, Min; Lu, Yong; Liang, Li-Rong; Zhang, Lei; Gao, Zi-Fen; Huang, Ke-Wu; Liu, Ying-Mei; Song, Shu-Fan; Wu, Lin; Yin, Yu-Dong; Wang, Chen title: Clinical Features of Pneumonia Caused by 2009 Influenza A(H1N1) Virus in Beijing, China date: 2015-12-16 journal: Chest DOI: 10.1378/chest.10-1036 sha: doc_id: 282151 cord_uid: mai4eggf BACKGROUND: Data on symptoms and radiographic changes in patients with pandemic 2009 influenza A(H1N1) (A[H1N1]) pneumonia during convalescence have not been reported. In our initial report of the A(H1N1) virus infection in China, the majority of patients had mild illness. keywords: a(h1n1; ards; group; infl; lung; manuscript; patients; uenza cache: cord-282151-mai4eggf.txt plain text: cord-282151-mai4eggf.txt item: #1277 of 2876 id: cord-282183-k0pn0ie2 author: Spiezia, Luca title: More severe hypercoagulable state in acute COVID-19 pneumonia as compared to other pneumonia. date: 2020-10-01 words: 1727 flesch: 33 summary: The results of our study show that COVID-19 patients admitted to medical wards for acute pneumonia had markedly hypercoagulable profiles on whole blood thromboelastometrycompared to COVID-19 negative patients with pneumonia -mainly -in a group of patients consecutively admitted to Internal Medicine wards of Padova University Hospital for acute pneumonia: cases were COVID-19 patients with pneumonia and controls were patients with pneumonia from different etiology. keywords: acute; covid-19; patients; pneumonia cache: cord-282183-k0pn0ie2.txt plain text: cord-282183-k0pn0ie2.txt item: #1278 of 2876 id: cord-282219-7kzbnymp author: Wu, Liu title: The effect of massage on the quality of life in patients recovering from COVID-19: A systematic review protocol date: 2020-06-05 words: 2458 flesch: 46 summary: [15] Massage therapy is characterized by the excellent therapeutic effect on analgesia, no side effect, easy to operate, low economic burden, and more beneficial to promote patients to recovery. We will include articles related to massage therapy of patients recovering from COVID-19. keywords: analysis; coronavirus; covid-19; data; massage; patients; quality; review cache: cord-282219-7kzbnymp.txt plain text: cord-282219-7kzbnymp.txt item: #1279 of 2876 id: cord-282361-gje78nb1 author: Gökce, Mehmet İlker title: How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE–IAU multicenter collaborative cohort study date: 2020-05-20 words: 3250 flesch: 40 summary: Regarding the unexpected and underestimated involvement of the world as well as modern medicine with COVID-19 pandemic in a truly unprepared status; many questions arose with respect to preoperative patient evaluation, as there was no standard approach and/or recommendations during problematic days. Also no alterations in method of anesthesia or stone related intervention was reported related to COVID-19 pandemic. keywords: anesthesia; covid-19; days; evaluation; patients; stone cache: cord-282361-gje78nb1.txt plain text: cord-282361-gje78nb1.txt item: #1280 of 2876 id: cord-282430-u5ukqc5z author: Fenton, Mark E. title: An Expanded COVID-19 Telemedicine Intermediate Care Model Using Repurposed Hotel Rooms date: 2020-10-15 words: 2175 flesch: 31 summary: Not only do patients who are positive for COVID-19 and are convalescing after acute care hospital admission transition there, but appropriate subacute patients identified in dedicated COVID-19 assessment centers and emergency rooms can also enter intermediate care according to established criteria (Table 1) . The Alveolar Recruitment Trial showed us that systematically performed recruitment maneuvers, known to cause alveolar overdistention, increased mortality rate in patients with acute respiratory distress syndrome (ARDS) (2) . keywords: care; covid-19; model; overdistention; patients; peep cache: cord-282430-u5ukqc5z.txt plain text: cord-282430-u5ukqc5z.txt item: #1281 of 2876 id: cord-282474-74273qgk author: Roehrig, Stefan title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-11 words: 2881 flesch: 51 summary: key: cord-282474-74273qgk authors: Roehrig, Stefan; Ait Hssain, Ali; Shallik, Nabil Al Hamid; Elsaid, Ingi Mohamed A.; Mustafa, Salma Faisal; Smain, Osama A. M.; Molokhia, Ashraf Abdulla; Lance, Marcus D. title: Flow controlled ventilation in Acute Respiratory Distress Syndrome associated with COVID-19: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-11 journal: Trials DOI: 10.1186/s13063-020-04708-1 sha: doc_id: 282474 cord_uid: 74273qgk OBJECTIVES: This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally ventilated patients (pressure control ventilation) in patients suffering from ARDS associated with COVID-19. keywords: ards; data; flow; patients; pressure; study; ventilation cache: cord-282474-74273qgk.txt plain text: cord-282474-74273qgk.txt item: #1282 of 2876 id: cord-282483-0zsvhoog author: Ghisa, Matteo title: Reorganization of the Functional Gastrointestinal Disorders Unit during the SARS-CoV-2 Outbreak - Practical Recommendations date: 2020-07-10 words: 663 flesch: 35 summary: Among the different areas of gastroenterology, the field of functional gastrointestinal disorders has witnessed a great reduction in human resources, infrastructures and available time slots, in order to make these resouces available for the fight COVID-19 2 . However, other diseases have not stopped to affect our patients and we confronted with the difficulties to provide the best care to patients with gastrointestinal diseases during this pandemic. keywords: covid-19; disorders; patients cache: cord-282483-0zsvhoog.txt plain text: cord-282483-0zsvhoog.txt item: #1283 of 2876 id: cord-282504-m3npy0om author: Kastritis, Efstathios title: Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID‐19 pandemic date: 2020-06-01 words: 4648 flesch: 37 summary: The use of ACE inhibitors or angiotensin-receptor blockers is limited in amyloidosis patients due to poor tolerance, but data do not support their discontinuation specifically for COVID-19(Hanff, et al 2020 , Vaduganathan, et al 2020 . The ISA drives an initiative to collect data of amyloidosis patients with COVID-19; ASH is also gathering data for patients with hematologic diseases and COVID-19, including patients with AL amyloidosis. keywords: 2020; amyloidosis; covid-19; et al; infection; patients; risk; therapy cache: cord-282504-m3npy0om.txt plain text: cord-282504-m3npy0om.txt item: #1284 of 2876 id: cord-282535-gnuhjs32 author: Cook, Gordon title: Real‐world assessment of the clinical impact of symptomatic infection with severe acute respiratory syndrome coronavirus (COVID‐19 disease) in patients with Multiple Myeloma receiving systemic anti‐cancer therapy. date: 2020-05-21 words: 1302 flesch: 42 summary: A disproportionate level of COVID-19 related mortality is noted in patients of Afro-Caribbean origin in our cohort ( Figure 1C ) compared to Caucasian patients but extreme caution is advised in relation to over interpreting this data given the actual low numbers of patients of non-Caucasian origin (n=10) reported in this audit despite the prevalence of MM(10) . This coupled with a median age at presentation of 70 years in a population with frequent co-existing medical conditions, means the outcomes of MM patients infected with COVID-19 warrants particular attention. keywords: covid-19; median; myeloma; patients cache: cord-282535-gnuhjs32.txt plain text: cord-282535-gnuhjs32.txt item: #1285 of 2876 id: cord-282589-xof56j98 author: Lopes, M. I. F. title: Beneficial effects of colchicine for moderate to severe COVID-19: an interim analysis of a randomized, double-blinded, placebo controlled clinical trial date: 2020-08-11 words: 3973 flesch: 50 summary: Clinical trials with larger numbers of patients should be conducted to further evaluate the efficacy and safety of colchicine as an adjunctive therapy for hospitalized patients with moderate to severe COVID-19. Clinical trials with larger numbers of patients should be conducted to further evaluate the efficacy and safety of colchicine as an adjunctive therapy for hospitalized patients with moderate to severe COVID-19. . keywords: colchicine; covid-19; day; days; group; patients; placebo; treatment cache: cord-282589-xof56j98.txt plain text: cord-282589-xof56j98.txt item: #1286 of 2876 id: cord-282610-zim7nond author: Proal, Amy title: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity date: 2018-12-04 words: 12434 flesch: 33 summary: Pathogens that persist inside human immune cells and associated tunneling nanotubuoles have been particularly hard to detect. Expanding research on the human microbiome now allows ME/CFS-associated pathogens to be studied as interacting members of human microbiome communities. keywords: activity; blood; cells; cfs; chronic; disease; et al; example; expression; gene; gut; host; human; immune; infection; microbes; microbial; microbiome; pathogens; patients; syndrome; viruses cache: cord-282610-zim7nond.txt plain text: cord-282610-zim7nond.txt item: #1287 of 2876 id: cord-282660-9x937eus author: Muñoz Vives, Josep Maria title: Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study date: 2020-05-06 words: 3219 flesch: 45 summary: Variables are described for the total number of included patients and separately for the number of patients who survived and those who had died. Variables are reported for the total number of included patients and also separately for the patients who survived and those who died. keywords: covid-19; fracture; hip; hospitals; mortality; patients; rate; study cache: cord-282660-9x937eus.txt plain text: cord-282660-9x937eus.txt item: #1288 of 2876 id: cord-282704-qg2o0ug4 author: Li, Xun title: Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China date: 2020-02-25 words: 2258 flesch: 55 summary: Malnutrition was common to severe patients. All the patients' albumin levels and 80% and 68% of patients' RBC and Hb levels were decreased, which indicates that malnutrition is common to severe patients. keywords: covid-19; levels; medrxiv; patients; preprint cache: cord-282704-qg2o0ug4.txt plain text: cord-282704-qg2o0ug4.txt item: #1289 of 2876 id: cord-282724-zzkqb0u2 author: Moore, Jason H. title: Ideas for how informaticians can get involved with COVID-19 research date: 2020-05-12 words: 7598 flesch: 28 summary: These are organized under sub-disciplines for biomedical informatics including Bioinformatics that focuses on basic science questions, Clinical Informatics that focuses on the delivery of healthcare, Clinical Research Informatics that focuses on research using clinical data, Consumer Health Informatics that focuses on the use of mobile devices and telemedicine, and Public Health informatics that focuses on research questions at the population or community level. Secure informatics platforms such as Integrating Bench to Bedside (i2b2) and the Shared Health Research Information Network (SHRINE), Trinetix, and Atlas play an important role in standardizing and harmonizing clinical data to common data models (CDMs) including i2b2, Patient-Centered Outcomes Research Network (PCORnet), Fast Healthcare Interoperability Resource (FHIR), and Observational Medical Outcomes Partnership (OMOP). keywords: analysis; cov-2; covid-19; data; disease; efforts; health; healthcare; informatics; models; pandemic; patients; public; research; researchers; sars; social; testing; tools cache: cord-282724-zzkqb0u2.txt plain text: cord-282724-zzkqb0u2.txt item: #1290 of 2876 id: cord-282730-pawasfh4 author: Contreras, Carlo M. title: Telemedicine: Patient-Provider Clinical Engagement During the COVID-19 Pandemic and Beyond date: 2020-05-08 words: 3570 flesch: 40 summary: This waiver also established equivalent reimbursement for video telemedicine visits and traditional in-person visits. At many institutions, the number of telemedicine visits dramatically increased within days following the institution of novel coronavirus pandemic restrictions on in-person clinical encounters. keywords: care; covid-19; data; pandemic; patients; telehealth; telemedicine; use; video; visits cache: cord-282730-pawasfh4.txt plain text: cord-282730-pawasfh4.txt item: #1291 of 2876 id: cord-282780-34j7gquo author: Lai, Kevin E. title: Tele-Neuro-Ophthalmology During the Age of COVID-19 date: 2020-06-26 words: 6301 flesch: 41 summary: The level of urgency dictates the type of visits available to the patient (e.g., in-person examination, video telemedicine visit, phone telemedicine visit, and interprofessional consultation) and the timeframe for management. If one seeks full integration of appointment scheduling, EHR, telemedicine visits, electronic medication orders, and patient portal communication, other platforms (e.g., AmWell, NextGen, and Zipnosis) offer more comprehensive services. keywords: care; content; covid-19; health; ipad; neuro; ophthalmology; patient; platform; services; telemedicine; testing; use; video; visit cache: cord-282780-34j7gquo.txt plain text: cord-282780-34j7gquo.txt item: #1292 of 2876 id: cord-282783-ps5jyjkl author: None title: Full Issue PDF date: 2020-09-30 words: 15963 flesch: 33 summary: Transthyretin amyloid cardiomyopathy: JACC state-of-the-art review Natural his A new staging system for cardiac transthyretin amyloidosis Cardiovascular disease mortality after chemotherapy or surgery for testicular nonseminoma: a populationbased study Testicular cancer: a Mechanisms of cisplatin nephrotoxicity White-Paper-1.pdf A new equation to estimate glomerular filtration rate Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel Marked impairment of protease-activated receptor type 1-mediated vasodilation and fibrinolysis in cigarette smokers: smoking, thrombin, and vascular responses in vivo Intra-arterial substance P mediated vasodilatation in the human forearm: pharmacology, reproducibility and tolerability Role of the endothelium in the vascular effects of the thrombin receptor (protease-activated receptor type 1) in humans Vascular effects of apelin in vivo in man The vasodilator action of nebivolol in forearm vasculature of subjects with essential hypertension Fire simulation and cardiovascular health in firefighters Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro Antiangiointravascular ultrasound imaging for coronary thrombosis after cisplatin-based chemotherapy Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis Arterial events in cancer patients-the case of acute coronary thrombosis Vascular toxic effects of cancer therapies Treatmentrelated cardiovascular toxicity in long-term survivors of testicular cancer Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer Impact of platinum-based chemotherapy on the progression of atherosclerosis Vascular fingerprint and vascular damage markers associated with vascular events in testicular cancer patients during and after chemotherapy Cardiovascular risk in long-term survivors of testicular cancer Long-term platinum retention after platinumbased chemotherapy in testicular cancer survivors: a 20-year follow-up study Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually Reduced mortality after allogeneic hematopoietic-cell transplantation Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study Vascular endothelium as 'novel' target of graft-versus-host disease Pericarditis in patients with chronic graft-vs-host disease National Institutes of Health hematopoietic cell transplantation late effects initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report Prevalence of outpatient cancer treatment in the United States: estimates from the Medical Panel Expenditures Survey (MPES) Chemotherapy-induced cardiotoxicity: detection, prevention, and management Long-term chemotherapy-related cardiovascular morbidity Cardiovascular disease in adult survivors of childhood cancer Epirubicin versus doxorubicin: which is the anthracycline of choice for the treatment of breast cancer? Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin Redox cycling of anthracyclines by cardiac mitochondria. However, elevations in TnI have also been observed in cancer patients receiving cancer therapy, including ICIs without any cardiotoxicities (23, 24) , thus suggesting that its utility may also be limited for the detection of iRC. keywords: age; anthracycline; cancer; cardiac; cardiotoxicity; cardiovascular; ccs; cell; checkpoint; chemotherapy; coronary; data; disease; doxorubicin; endothelial; events; factors; failure; heart; ibrutinib; immune; myocarditis; patients; risk; study; survivors; table; term; therapy; treatment; years cache: cord-282783-ps5jyjkl.txt plain text: cord-282783-ps5jyjkl.txt item: #1293 of 2876 id: cord-282867-kbyxdegu author: Shah, Sayed Zulfiqar Ali title: Scaling the Need, Benefits, and Risks Associated with COVID-19 Acute and Postacute Care Rehabilitation: A Review date: 2020-08-26 words: 4550 flesch: 35 summary: Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents Rehabilitation Research and Practice Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors Six month radiological and physiological outcomes in severe acute respiratory syndrome (SARS) survivors A major outbreak of severe acute respiratory syndrome in Hong Kong Rehabilitation and respiratory management in the acute and early post-acute phase Pathogenesis and natural history of osteonecrosis Avascular necrosis of bone in severe acute respiratory syndrome Steroidinduced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy Chest physiotherapy for pneumonia in adults Chest physiotherapy in primary pneumonia Epidemiology and outcome of acute respiratory failure in intensive care unit patients Effects of sputum on pulmonary function A randomised controlled trial of the effectiveness of an exercise training program in patients recovering from severe acute respiratory syndrome Pulmonary rehabilitation for patients with coronavirus disease 2019 (COVID-19) Acute care physiotherapy management of COVID-19 patients in Qatar: consensus-based recommendations A randomized evaluation of the acute efficacy, acceptability and tolerability of flutter and active cycle of breathing with and without postural drainage in non-cystic fibrosis bronchiectasis Endotracheal suction in intubated critically ill adult patients undergoing mechanical ventilation: a systematic review Chest physiotherapy in mechanically ventilated patients without pneumonia-a narrative review Chest physical therapy for children hospitalised with acute pneumonia: a randomised controlled trial Long-term comparative trial of two different physiotherapy techniques; postural drainage with percussion and autogenic drainage, in the treatment of cystic fibrosis Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study Respiratory physiotherapy in patients with COVID-19 infection in acute setting: a position paper of the Italian Association of Respiratory Physiotherapists (ARIR) According to consensus-based acute care physiotherapy recommendations developed in Qatar, rehabilitation patients could be categorized into the following six categories: Category A (paralyzed, ventilated, and sedated), Category B (ventilated and minimally sedated), Category C (no mechanical ventilation), Category C.1 (bedridden but minimally conscious), Category C.2 (conscious and active but dependent), and Category C.3 (independent, active, and conscious). keywords: acute; chest; coronavirus; covid-19; patients; physiotherapy; pneumonia; rehabilitation; sars; syndrome; techniques; treatment cache: cord-282867-kbyxdegu.txt plain text: cord-282867-kbyxdegu.txt item: #1294 of 2876 id: cord-282912-jegpgqqi author: Pilato, Emanuele title: Mechanical complications of Myocardial Infarction during Covid-19 Pandemic: An Italian single-Centre experience: Heart ruptures in covid-19 era date: 2020-09-18 words: 1396 flesch: 39 summary: key: cord-282912-jegpgqqi authors: Pilato, Emanuele; Pinna, Giovanni Battista; Parisi, Valentina; Manzo, Rachele; Comentale, Giuseppe title: Mechanical complications of Myocardial Infarction during Covid-19 Pandemic: An Italian single-Centre experience: Heart ruptures in covid-19 era date: 2020-09-18 journal: Heart Lung DOI: 10.1016/j.hrtlng.2020.09.004 sha: doc_id: 282912 cord_uid: jegpgqqi COVID-19 pandemic triggered in many patients the fear to go to the emergency rooms in order to avoid a possible infection. The large widespread of the infection and the great overload of the intensive care units made the hospital as possible contagion areas, so it triggered in many patients the fear to go to the emergency rooms [1] . keywords: acs; covid-19; patients; rupture cache: cord-282912-jegpgqqi.txt plain text: cord-282912-jegpgqqi.txt item: #1295 of 2876 id: cord-282956-f7if9e5q author: Yaghi, Shadi title: SARS2-CoV-2 and Stroke in a New York Healthcare System date: 2020-05-26 words: 2892 flesch: 35 summary: We compared the clinical characteristics of stroke patients with a concurrent diagnosis of COVID-19 to stroke patients without COVID-19 (contemporary controls). Our study also shows that the number of COVID-19 positive ischemic strokes has increased initially but seems to have peaked and then decreased. keywords: acute; controls; covid-19; disease; patients; stroke; study cache: cord-282956-f7if9e5q.txt plain text: cord-282956-f7if9e5q.txt item: #1296 of 2876 id: cord-282963-p04c5nn7 author: Oliveros, Estefania title: Rapid Deterioration of Hospital-Acquired COVID-19 in a Patient on Extracorporeal Left Ventricular Assist Support date: 2020-09-21 words: 1066 flesch: 41 summary: First, this case underscores the rapidity of deterioration in COVID-19 patients once hypoxia starts. First, this case underscores the rapidity of deterioration in COVID-19 patients once hypoxia starts. keywords: asymptomatic; case; covid-19; patients cache: cord-282963-p04c5nn7.txt plain text: cord-282963-p04c5nn7.txt item: #1297 of 2876 id: cord-283141-dh8j7lyl author: Haskologlu, Sule title: Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency date: 2020-03-11 words: 2607 flesch: 42 summary: Hematopoietic stem cell transplantation as treatment for patients with DOCK8 deficiency Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 (DOCK8) deficiency Haploidentical related donor hematopoietic stem cell transplantation for dedicator of cytokinesis 8 deficiency using post transplantation cyclophosphamide Curative treatment of autosomal-recessive hyper-IgE syndrome by hematopoietic cell transplantation Successful long-term correction of autosomal recessive hyper-IgE syndrome due to DOCK8 deficiency by hematopoietic stem cell transplantation Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency Successful allogeneic hematopoietic stem cell transplantation for DOCK8 deficiency Successful bone marrow transplantation for DOCK8 deficient hyper IgE syndrome Clinical and immunological correction of DOCK8 deficiency by allogeneic hematopoietic stem cell transplantation following a reduced toxicity conditioning regimen In DOCK8 deficiency donor cell engraftment post-genoidentical hematopoietic stem cell transplantation is possible without conditioning Successful hematopoietic stem cell transplantation after myeloablative conditioning in three patients with dedicator of cytokinesis 8 deficiency (DOCK8) related Hyper IgE syndrome Hematopoietic stem cell transplantation from unrelated donors in children with DOCK8 deficiency Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency Consensus conference on acute GVHD grading National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: We aimed to report the experience of our center and the result of the largest transplantation series of DOCK8 deficiency in our country. keywords: cell; deficiency; dock8; hsct; patients; transplantation cache: cord-283141-dh8j7lyl.txt plain text: cord-283141-dh8j7lyl.txt item: #1298 of 2876 id: cord-283165-mdkr9qo0 author: Russell, C.D. title: Diagnosis and features of hospital-acquired pneumonia: a retrospective cohort study date: 2015-12-15 words: 3887 flesch: 33 summary: The mortality rate during admission for patients with radiologically confirmed HAP was 20.4%, with 5.6% of patients requiring admission to the ICU and mechanical ventilation following HAP diagnosis. Improved accuracy of HAP diagnosis is essential, since around one-third of patients in our cohort were exposed to broad-spectrum antimicrobials potentially unnecessarily and may have had an alternative diagnosis requiring different investigation and management. keywords: admission; antimicrobials; diagnosis; hap; patients; pneumonia; sputum; study cache: cord-283165-mdkr9qo0.txt plain text: cord-283165-mdkr9qo0.txt item: #1299 of 2876 id: cord-283215-dgysimh5 author: Al-Jabir, Ahmed title: Impact of the coronavirus (COVID-19) pandemic on surgical practice - Part 2 (surgical prioritisation) date: 2020-05-12 words: 9062 flesch: 40 summary: An anaesthetic guideline for COVID-19 positive patients is required. For more at risk patients (such as the elderly or immunosuppressed) with a low tumour burden, a reduced dose (≥85% of the standard dose) is recommended. keywords: cancer; care; cases; coronavirus; covid-19; emergency; guidelines; hospital; management; pandemic; patients; procedures; risk; surgeons; surgery; transplant; treatment; triage cache: cord-283215-dgysimh5.txt plain text: cord-283215-dgysimh5.txt item: #1300 of 2876 id: cord-283231-ju71zm7w author: Yu, Juan title: RE: Respiratory Infectious Disease in Resource Limited Setting: Radiology Management Advice date: 2020-04-15 words: 560 flesch: 49 summary: Special examination rooms and passageways should be reserved for suspected patients. If there is no special examination room for suspected patients, try to divide the time period for the ordinary patients and suspected patients. keywords: examination; patients cache: cord-283231-ju71zm7w.txt plain text: cord-283231-ju71zm7w.txt item: #1301 of 2876 id: cord-283267-72wrzw09 author: Moores, Lisa K. title: Prevention, diagnosis and treatment of venous thromboembolism in patients with COVID-19: CHEST Guideline and Expert Panel Report date: 2020-06-02 words: 8243 flesch: 35 summary: An updated analysis High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Incidence of venous thromboembolism in hospitalized patients with COVID-19 Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom Risk assessment of venous thromboembolism and bleeding in COVID-19 patients Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: The incidence of VTE in COVID-19 patients is not well defined, but early reports suggest it may be higher than in non-COVID hospitalized patients with similar degrees of illness, even in the presence of prophylactic anticoagulation. keywords: anticoagulant; anticoagulation; bleeding; covid-19; evidence; lmwh; medical; patients; risk; studies; thromboembolism; thromboprophylaxis; vte cache: cord-283267-72wrzw09.txt plain text: cord-283267-72wrzw09.txt item: #1302 of 2876 id: cord-283513-3f4rsgzm author: Jaywant, Abhishek title: Behavioral interventions in acute COVID-19 recovery: A new opportunity for integrated care date: 2020-07-07 words: 1265 flesch: 29 summary: There are likely multifactorial physiologic and psychologic contributions to anxiety symptoms as neurologically-based sensory changes (e.g., dysautonomia) occur in deconditioned COVID-19 patients [3] . Patients are medically monitored and work towards rehabilitation goals with daily physical and occupational therapy (PT/OT). keywords: covid-19; patients cache: cord-283513-3f4rsgzm.txt plain text: cord-283513-3f4rsgzm.txt item: #1303 of 2876 id: cord-283517-7gd0f06m author: Deak, Eszter title: Right-Sizing Technology in the Era of Consumer-Driven Health Care date: 2017-08-01 words: 6867 flesch: 42 summary: Test results did suggest that some influence on physician behavior occurred, as patients diagnosed with influenza had fewer ancillary tests ordered (45% versus 53% of visits), fewer antibiotic prescriptions (11% versus 23%), and increased antiviral use (56% versus 19%) when the diagnosis was made in association with RIDT. The goal of the ACA was to improve the quality of and access to health care by transforming insurance coverage and lowering health care costs. keywords: care; clia; cost; health; impact; influenza; laboratory; mpoc; patient; results; technology; testing; tests; time; use cache: cord-283517-7gd0f06m.txt plain text: cord-283517-7gd0f06m.txt item: #1304 of 2876 id: cord-283583-pwlbrxn3 author: Zhang, Xiao-Ai title: Prevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012 date: 2015-01-09 words: 3788 flesch: 47 summary: SAFV infection might be associated with a wide clinical spectrum and contribute to HFMD. myocardium of a previously healthy child who experienced sudden death, suggesting that the virus might cause serious invasive infection in children 25 . However, given the insufficient systematic data, the epidemiological and genetic characteristics of SAFV infection remain ambiguous. keywords: cohort; detection; encephalitis; hfmd; patients; safv; samples; study cache: cord-283583-pwlbrxn3.txt plain text: cord-283583-pwlbrxn3.txt item: #1305 of 2876 id: cord-283682-4fcyoyea author: Chan, Edward D. title: Mycoplasma pneumoniae-Associated Bronchiolitis Causing Severe Restrictive Lung Disease in Adults Report of Three Cases and Literature Review date: 1999-04-30 words: 3976 flesch: 33 summary: There were two with respiratory bronchiolitis, one with panbronchiolitis, one patient with bronchiolitis obliterans organizing pneumonia (BOOP), and six with acute inflammatory bronchiolitis. Although the type of bronchiolitis was not described further, 12 the restrictive changes noted on pulmonary function tests would argue against constrictive bronchiolitis obliterans and would be more representative of BOOP or inflammatory bronchiolitis. keywords: alveolar; boop; bronchiolitis; chest; disease; lung; mycoplasma; obliterans; patient; pneumoniae cache: cord-283682-4fcyoyea.txt plain text: cord-283682-4fcyoyea.txt item: #1306 of 2876 id: cord-283719-zmizyx7e author: Cheng, Yuan-Yang title: Rehabilitation Programs for Patients with COronaVIrus Disease 2019: Consensus Statements of Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation date: 2020-08-17 words: 2816 flesch: 23 summary: 36 Rehabilitation interventions for such patients should include the following: (1) Active or active-assisted range of motion (ROM) exercise: Patients with moderate to severe disease who are able to actively move their extremities are encouraged to engage in active or active-assisted ROM exercises to maintain or improve joint integrity and prevent joint contracture and soft-tissue shortening. However, a formal exercise test should still be considered in patients with advanced CVD with proper clinical disinfection following CDC 11 (3) Pulmonary disease: Patients with previous chronic pulmonary diseases could develop much more airway secretions than those without. keywords: covid-19; disease; exercise; patients; rehabilitation; risk; training cache: cord-283719-zmizyx7e.txt plain text: cord-283719-zmizyx7e.txt item: #1307 of 2876 id: cord-283738-v3h7p297 author: Makar, Michael title: Gastrointestinal Findings in a Patient With COVID-19 date: 2020-06-11 words: 1431 flesch: 43 summary: We present a patient diagnosed with coronavirus who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. We present a patient diagnosed with COVID-19 who presented with several days of GI symptoms and discuss the relevance of GI disease and liver injury in these patients. keywords: covid-19; liver; patients; symptoms cache: cord-283738-v3h7p297.txt plain text: cord-283738-v3h7p297.txt item: #1308 of 2876 id: cord-283779-mudwcypl author: Lauretani, Fulvio title: Assessment and treatment of older individuals with COVID-19 multi-system disease: clinical and ethical implications date: 2020-05-11 words: 9739 flesch: 35 summary: As a consequence of multimorbidity, polypharmacy defined as the number of drugs reported at hospital admission and the potential drug-drug interactions require a careful evaluation in older COVID-19 patients. These principles have been often ignored, especially in older COVID-19 patients. keywords: acute; care; coronavirus; covid-19; day; days; disease; infection; mortality; nutritional; patients; phase; pulmonary; risk; sars; symptoms; syndrome; treatment; use; virus cache: cord-283779-mudwcypl.txt plain text: cord-283779-mudwcypl.txt item: #1309 of 2876 id: cord-283806-a6exd6dn author: Menardi, Endrj title: Telemedicine during COVID‐19 pandemic date: 2020-05-30 words: 684 flesch: 26 summary: Since 2015 most patients implanted with cardiac devices (Implantable Cardioverter Defibrillators (ICDs), Implantable Loop Recorders (ILRs), Pacemakers (PMs)) at Santa Croce e Carle Hospital (Cuneo, Italy) are remotely followed with home monitoring systems free of charge. From 2017 the home monitoring outpatient follow‐up service has been systematically organized mainly for the peculiar geographical features (typically mountainous, vast and with few roads) of the territory served by our hospital, making difficult for patients the access to the health care facilities. keywords: hospital; monitoring; patients cache: cord-283806-a6exd6dn.txt plain text: cord-283806-a6exd6dn.txt item: #1310 of 2876 id: cord-283826-lgyc3sro author: Stiehm, E. Richard title: Therapeutic Use of Immunoglobulins date: 2010-11-05 words: 9757 flesch: 33 summary: A randomized double-blind trial Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency High dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura Fcg receptor as regulators of immune responses Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc Identification of a receptor required for the anti-inflammatory activity of IVIG Mechanism of intravenous immune globulin therapy in antibody-mediated autoimmune diseases Accelerated autoantibody clearance by intravenous immunoglobulin therapy: Intravenous immune globulin for the prevention of bacterial infections in children with symptomatic human immunodeficiency virus infection Passive antibody therapies: progress and continuing challenges Antitoxin versus no antitoxin in scarlet fever Adjunctive treatment of streptococcal toxic shock syndrome using intravenous immunoglobulin: case report and review Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome Clinical usefulness of intravenous human immunoglobulins in invasive group keywords: antibodies; antibody; antitoxin; diseases; dose; high; human; igg; immune; immunodeficiency; immunoglobulin; infection; intravenous; ivig; patients; primary; studies; syndrome; therapy; treatment; use; virus cache: cord-283826-lgyc3sro.txt plain text: cord-283826-lgyc3sro.txt item: #1311 of 2876 id: cord-283969-wqrzaxsu author: Antonucci, Michele title: The impact of COVID-19 outbreak on urolithiasis emergency department admissions, hospitalizations and clinical management in central Italy: a multicentric analysis date: 2020-10-28 words: 2928 flesch: 36 summary: Patients and methods We conducted a multicentric retrospective analysis of ED admissions in three high volume urology departments (one directly involved in COVID-19 patients management and two not involved) in Rome - Italy between March and April 2020 and in the same period of 2019. In Italy not all the regions were affected by the same overload of COVID-19 cases; some cities had the opportunity to select the hospitals in which infected patients had to be admitted, leaving some structures free from COVID-19 patients. keywords: admissions; covid-19; emergency; pandemic; patients; stone; urolithiasis cache: cord-283969-wqrzaxsu.txt plain text: cord-283969-wqrzaxsu.txt item: #1312 of 2876 id: cord-284038-93s3ffoy author: Keyhanian, Kiandokht title: SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation date: 2020-11-07 words: 11721 flesch: 30 summary: Viruses Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Coupling viruses to dynein and kinesin-1. A first step in understanding SARS pathogenesis Propagation of swine hemagglutinating encephalomyelitis virus and pseudorabies virus in dorsal root ganglia cells Expression of the monoclonal antibody against nucleocapsid antigen of SARS-associated coronavirus in autopsy tissues from SARS patients. keywords: acute; brain; case; cells; cns; coronavirus; cov-2; covid-19; csf; disease; encephalitis; et al; human; infection; patients; pcr; r n; receptor; sars; study; symptoms; syndrome; system cache: cord-284038-93s3ffoy.txt plain text: cord-284038-93s3ffoy.txt item: #1313 of 2876 id: cord-284042-awl5bb0j author: Carrascosa, J.M. title: Cutaneous Manifestations in the Context of SARS-CoV-2 Infection (COVID-19)() date: 2020-10-15 words: 3954 flesch: 39 summary: A description of 74 cases from a tertiary university hospital in Spain Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients Clinical and histological characterization of vesicular COVID-19 rashes: A prospective study in a tertiary care hospital Acute urticaria with pyrexia as the first manifestations of a COVID-19 infection Acute urticaria with pyrexia as the first manifestations of a COVID-19 infection: Urticaria-like lesions in COVID-19 patients are not really urticaria. Hedou et al., 9 in response to the aforementioned article, reported skin lesions attributable to COVID-19 in 4.9% of patients with a positive polymerase chain reaction (PCR) test result in a series of 103 patients. keywords: cases; cov-2; covid-19; infection; lesions; manifestations; patients; sars; skin; symptoms cache: cord-284042-awl5bb0j.txt plain text: cord-284042-awl5bb0j.txt item: #1314 of 2876 id: cord-284163-3jmqzemf author: Seffer, Malin-Theres title: Heparin 2.0: A New Approach to the Infection Crisis date: 2020-07-02 words: 2986 flesch: 36 summary: This narrative review will give a brief overview regarding some of the extracorporeal devices that could be used to treat COVID-19 patients, including the Seraph® 100 Microbind® Affinity Blood Filter, produced by ExThera Medical (Martinez, CA, USA), first licensed in the European Economic Area in 2019. Interestingly detectable serum SARS-Cov-2 RNA in the blood of COVID-19 patients has been shown to be associated with elevated IL-6 concentration and poor prognosis keywords: blood; covid-19; extracorporeal; heparin; patients; seraph; surface cache: cord-284163-3jmqzemf.txt plain text: cord-284163-3jmqzemf.txt item: #1315 of 2876 id: cord-284175-5rre1kbn author: Elsaid, Ossama title: Ventricular Fibrillation Storm in Coronavirus 2019 date: 2020-08-29 words: 1091 flesch: 29 summary: The patient had heart failure with reduced ejection fraction and coronary artery disease Coronavirus Disease (COVID-19) Situation Reports Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19) Clinical Characteristics of Covid-19 in Cardiac Arrhythmias in COVID-19 Infection QT interval prolongation and torsade de pointes in patients with COVID-19 treated with hydroxychloroquine/azithromycin In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan COVID-19 and cardiac arrhythmias 1, 2 Due to the panoply of precipitating factors that can cause cardiac arrhythmia in COVID-19 patients, identifying the underlying culprit is crucial for proper management. keywords: covid-19; inflammation; patients; qtc cache: cord-284175-5rre1kbn.txt plain text: cord-284175-5rre1kbn.txt item: #1316 of 2876 id: cord-284188-ujdla954 author: Smith, Silas W. title: Virtual Urgent Care Quality and Safety in the Time of Coronavirus date: 2020-10-16 words: 5915 flesch: 46 summary: VUC patients are not directly comparable with ED patients; various complex factors contribute to decision thresholds to access these various care modalities. We performed a retrospective cohort analysis in a single hospital network of VUC patients from March 1, 2020 through April 20, 2020. keywords: care; comorbidities; covid-19; emergency; follow; health; pandemic; patients; period; telehealth; telemedicine; visit; vuc cache: cord-284188-ujdla954.txt plain text: cord-284188-ujdla954.txt item: #1317 of 2876 id: cord-284251-brn5izwo author: Melmed, Kara R. title: Risk factors for intracerebral hemorrhage in patients with COVID-19 date: 2020-09-24 words: 3643 flesch: 37 summary: In ICH patients, the indication for therapeutic anticoagulation was elevated D-dimer in 18 (54.5%) patients, while this was the indication in only 14.9% of patients without ICH (p < 0.001). Patients with ICH who were on therapeutic anticoagulation had a non-statistically significant higher mortality than ICH patients who were not on anticoagulation (14 vs To further determine the predictive value of markers of coagulation for ICH, the ROC curve for coagulation abnormalities was plotted (Fig. 2) . keywords: anticoagulation; covid-19; hemorrhage; ich; neuroimaging; patients; risk; use cache: cord-284251-brn5izwo.txt plain text: cord-284251-brn5izwo.txt item: #1318 of 2876 id: cord-284298-tcied4l5 author: Ojeahere, Margaret Isioma title: Management of psychiatric conditions and delirium during the COVID-19 pandemic across continents: The lessons thus far date: 2020-09-19 words: 6819 flesch: 32 summary: Lebanon has included hydroxychloroquine as part of the regimen used for COVID-19 patients in the ICU. The Thai village health volunteers have played important roles, not only for COVID-19 patients but in providing healthcare generally. keywords: care; cases; conditions; countries; covid-19; delirium; et al; health; management; pandemic; patients; psychiatric; r n cache: cord-284298-tcied4l5.txt plain text: cord-284298-tcied4l5.txt item: #1319 of 2876 id: cord-284332-p4c1fneh author: Bosma, Karen J. title: Pharmacotherapy for Prevention and Treatment of Acute Respiratory Distress Syndrome: Current and Experimental Approaches date: 2012-09-19 words: 14538 flesch: 29 summary: The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a metaanalysis of outcome data Efficacy of an expanded ventilator bundle for the reduction of ventilatorassociated pneumonia in the medical intensive care unit Continuous aspiration of subglottic secretions in the prevention of ventilatorassociated pneumonia in the postoperative period of major heart surgery Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial Thromboprophylaxis in medicalsurgical critically ill patients Stress ulcer prophylaxis in critically ill patients: resolving discordant meta-analyses Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial Effects of physical training on functional status in patients with prolonged mechanical ventilation Recent trends in acute lung injury mortality: 1996-2005 Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Effect of prone positioning in patients with acute respiratory distress syndrome: a metaanalysis Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis1 Hemodynamic and gas exchange response to inhaled nitric oxide and prone positioning in acute respiratory distress syndrome patients High-frequency oscillatory ventilation in adults: the Toronto experience High-frequency oscillatory ventilation for adult patients with ARDS Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome Ketoconazole prevents acute respiratory failure in critically ill surgical patients A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats Rosiglitazone attenuates the severity of sodium taurocholate-induced acute pancreatitis and pancreatitis-associated lung injury Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: phase IIb, multicenter, randomized, placebo-controlled, clinical trial Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial The Beta-Agonist Lung Injury Trial (BALTI): a randomized placebo-controlled clinical trial Randomized, placebo-controlled trial of an aerosolized beta-2 adrenergic agonist (albuterol) for the treatment of acute lung injury Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome: Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group Bovine surfactant therapy for patients with acute respiratory distress syndrome Venticute in patients with pneumonia or aspiration of gastric contents and intubation/ventilation/oxygenation impairment (BY2001/M1-007) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury Arachidonic acid remodeling in human inflammatory cells migrating to the lung in vivo Recent advances in genetic predisposition to clinical acute lung injury Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock Pharmacotherapy of acute lung injury and acute respiratory distress syndrome Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome Does programmed cell death (apoptosis) play a role in the development of multiple organ dysfunction in critically ill patients? keywords: acute; ali; alveolar; ards; day; distress; group; injury; lung; mortality; neutrophil; patients; phase; results; risk; studies; study; surfactant; syndrome; treatment; trial; ventilation cache: cord-284332-p4c1fneh.txt plain text: cord-284332-p4c1fneh.txt item: #1320 of 2876 id: cord-284365-g46myqe7 author: Guo, Qian title: Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study date: 2020-05-19 words: 4765 flesch: 39 summary: Future research could focus on the mediating role of coping strategies and gender differences in the stress-related symptoms of patients, and the cause and consequence of the stigma associated with the psychopathology symptoms of COVID-19 patients. Results revealed that COVID-19 patients, when compared to non-COVID controls, manifested higher levels of depression (P < 0.001), anxiety (P < 0.001), and post-traumatic stress symptoms (P < 0.001). keywords: covid-19; depression; et al; levels; patients; stress; study; symptoms cache: cord-284365-g46myqe7.txt plain text: cord-284365-g46myqe7.txt item: #1321 of 2876 id: cord-284387-cjziykrz author: Garcia-Castrillo, Luis title: European Society For Emergency Medicine position paper on emergency medical systems’ response to COVID-19 date: 2020-05-04 words: 2353 flesch: 38 summary: Potential case definition A person with acute respiratory infection and no other causes for the infection and at least one of the following: (1) travel or stay in countries with known outbreak, or in one of the countries where the virus has spread in the previous 14 days or (2) the patient is a member of a medical team working on patients infected with coronavirus or with a respiratory infection of an unknown cause or (3) has worked with or has been in close contact with patients with respiratory infections of unknown origin or of known SARS-CoV-2 origin in the previous 14 days. The suspected patients who will be sent to isolation wards or ICU, or transferred to a dedicated centre ward, or isolated at home should remain in a specific isolated area, minimising movements and contact with other patients within the ER. keywords: cases; coronavirus; emergency; healthcare; patients; sars cache: cord-284387-cjziykrz.txt plain text: cord-284387-cjziykrz.txt item: #1322 of 2876 id: cord-284454-malfatni author: McCall, W. Travis title: Caring for Patients From a School Shooting: A Qualitative Case Series in Emergency Nursing date: 2020-08-19 words: 5450 flesch: 44 summary: Emergency nurses are at risk for secondary traumatic stress, compassion fatigue, and burnout as a result of witnessing the trauma and suffering of patients. The traumatic events perceived as being most stressful for emergency nurses involve sudden death, children, and adolescents. keywords: care; emergency; emergency nurses; nurses; patients; school; shooting; stress; trauma cache: cord-284454-malfatni.txt plain text: cord-284454-malfatni.txt item: #1323 of 2876 id: cord-284526-a5kgo4ct author: Gavriilaki, Eleni title: Endothelial Dysfunction in COVID-19: Lessons Learned from Coronaviruses date: 2020-08-27 words: 6013 flesch: 26 summary: Translational lessons from animal models Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Clin Microbiol Infect: the official publication of the European Society of Clinical Microbiology and Infectious Diseases COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features A first case of meningitis/encephalitis associated with SARS-Coronavirus-2 Acute disseminated encephalomyelitis after SARS-CoV-2 infection Severe COVID-19 infection and thrombotic microangiopathy: success does not come easily A case-series study describing a possible pathophysiologic mechanism of severe COVID-19 infection unravelled the catastrophic microvascular injury syndrome mediated by complement cascade Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Autopsy findings and venous thromboembolism in patients with COVID-19 Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Pulmonary embolism in COVID-19 patients: awareness of an increased prevalence Incidence of venous thromboembolism in hospitalized patients with COVID-19 High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum Scientific and standardization committee communication: clinical guidance on the diagnosis, prevention and treatment of venous thromboembolism in hospitalized patients with COVID In parallel with autopsy findings, high rates of VTE (10 to 43%, especially PE) have been clinically diagnosed in COVID-19 patients in intensive care units (ICUs) keywords: acute; case; coronavirus; covid-19; disease; dysfunction; endothelial; icu; infection; patients; sars; study; syndrome cache: cord-284526-a5kgo4ct.txt plain text: cord-284526-a5kgo4ct.txt item: #1324 of 2876 id: cord-284545-vn60yd46 author: Sanyaolu, Adekunle title: Comorbidity and its Impact on Patients with COVID-19 date: 2020-06-25 words: 3752 flesch: 50 summary: In the USA, the Centers for Disease Control and Prevention (CDC) uses COVID-NET in 14 states to monitor the demographics of COVID-19 patients who are being hospitalized [6] . A meta-analysis study of COVID-19 patients, as depicted in Fig. 1 , showed fever (88.8%) as the most common symptom, followed by dry cough (68%) and fatigue (33%) keywords: comorbidities; coronavirus; covid-19; diabetes; disease; patients; risk cache: cord-284545-vn60yd46.txt plain text: cord-284545-vn60yd46.txt item: #1325 of 2876 id: cord-284576-nemh4wdo author: Sims, Jonathan T. title: Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19 date: 2020-09-10 words: 1652 flesch: 22 summary: Proceedings of the National Academy of 254 Sciences CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human 257 alveolar epithelial cells type II A systems approach to inflammation identifies therapeutic targets in SARS-260 CoV-2 infection Remdesivir in adults with severe 262 COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Comparison of an ordinal endpoint to time-to-event, longitudinal, and binary endpoints for use in 266 evaluating treatments for severe influenza requiring hospitalization Anticoagulant treatment is associated with 269 decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Prevalence of venous thromboembolism in patients 272 with severe novel coronavirus pneumonia Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and 275 call for action Soluble 277 CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with 278 and without overt ischemic heart disease Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular 283 diseases: the therapeutic potential of PARP inhibitors key: cord-284576-nemh4wdo authors: Sims, Jonathan T.; Krishnan, Venkatesh; Chang, Ching-Yun; Engle, Sarah M.; Casalini, Giacomo; Rodgers, George H.; Bivi, Nicoletta; Nickoloff, Brian J.; Konrad, Robert J.; de Bono, Stephanie; Higgs, Richard E.; Benschop, Robert J.; Ottaviani, Silvia; Cardoso, Anabela; Nirula, Ajay; Corbellino, Mario; Stebbing, Justin title: Characterization of the Cytokine Storm Reflects Hyperinflammatory Endothelial Dysfunction in COVID-19 date: 2020-09-10 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.08.031 sha: doc_id: 284576 cord_uid: nemh4wdo Background Physicians treating COVID-19 patients increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a cytokine storm. keywords: biomarkers; covid-19; cytokine; fig; patients cache: cord-284576-nemh4wdo.txt plain text: cord-284576-nemh4wdo.txt item: #1326 of 2876 id: cord-284804-6i5zbmm1 author: Pan, Feng title: Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study date: 2020-05-18 words: 4632 flesch: 46 summary: The consecutive admission records were reviewed retrospectively for the period from 27 January 2020 to 19 Regular bedside chest digital radiographs (DRs) were regularly performed every 1 to 3 days instead of conventional computed tomography (CT) scans after admission owing to the risk during the transfer of severe patients. Therefore, the dynamic monitoring of these laboratory parameters could estimate the prognosis in clinical practice for severe patients. keywords: admission; course; covid-19; death; event; group; lymphocyte; patients; study cache: cord-284804-6i5zbmm1.txt plain text: cord-284804-6i5zbmm1.txt item: #1327 of 2876 id: cord-284910-vjcrhwqz author: Kirresh, Ali title: COVID-19 infection and high intracoronary thrombus burden date: 2020-07-30 words: 1774 flesch: 28 summary: Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China Chimeric antigen receptor T cells for sustained remissions in leukemia A Case of Coronavirus Disease 2019 With Concomitant Acute Cerebral Infarction and Deep Vein Thrombosis Cerebral Venous Sinus Thrombosis as a Presentation of COVID-19 Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality Influenza and Cardiovascular Disease Is There a Causal Relationship? Coronary plaque instability in severe acute respiratory syndrome Review Article -High thrombus burden: a review of mechanisms and treatments Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke Hypochlorous acid, a macrophage product, induces endothelial apoptosis and tissue factor expression: involvement of myeloperoxidase-mediated oxidant in plaque erosion and thrombogenesis Coagulopathy and Antiphospholipid Antibodies in Patients with COVID-19 Pathogenesis of antiphospholipid syndrome: understanding the antibodies Association of Treatment Dose Anticoagulation With In-Hospital Survival Among Hospitalized Patients With COVID-19 DOACs vs LMWHs in hospitalized medical patients: a systematic review and meta-analysis that informed 2018 ASH guidelines Platelet Inhibition With Cangrelor and Crushed Ticagrelor in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention High rates of prasugrel and ticagrelor non-responder in patients treated with therapeutic hypothermia after cardiac arrest Impaired bioavailability and antiplatelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR) Effect of cangrelor on periprocedural outcomes in percutaneous coronary interventions: a pooled analysis of patient-level data TCT-79 efficacy of cangrelor in lesions with high-risk and low-risk angiographic characteristics: the CHAMPION PHOENIX trial Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): Pooled analysis of early reports High thrombus burden in myocardial infarction is a real challenge and has an increased risk of no reflow, slow reflow, and distal embolization (16) . keywords: burden; covid-19; patients; risk; thrombosis; thrombus cache: cord-284910-vjcrhwqz.txt plain text: cord-284910-vjcrhwqz.txt item: #1328 of 2876 id: cord-284944-hcgfe9wv author: Silvin, Aymeric title: Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19 date: 2020-08-05 words: 10810 flesch: 35 summary: Severe patients exhibited an expansion in the proportion of circulating neutrophils within the peripheral blood cell population (Figure 1E) , which was associated with an increase in their absolute number (Table S2) , as already reported . Focusing on neutrophil subsets, we noticed a slight increase in the fraction of CD10 Low CD101 + neutrophils in mild COVID-19 patients (Figure 1F) , whereas the fraction of CD10 Low CD101neutrophils was remarkably amplified in severe patients, suggesting an accumulation of immature subsets of neutrophils (Ng et al., 2019) in the peripheral blood of these patients ( Figure 1G and S1C-E). keywords: analysis; blood; calprotectin; cd14; cd16; cells; controls; covid-19; covid-19 patients; disease; et al; expression; figure; fraction; hla; levels; low; monocytes; neutrophils; patients; plasma cache: cord-284944-hcgfe9wv.txt plain text: cord-284944-hcgfe9wv.txt item: #1329 of 2876 id: cord-284979-lyt98od1 author: Sia, Charmaine Si Min title: Critical Coronavirus Disease 2019 in a Hemodialysis Patient: A Proposed Clinical Management Strategy date: 2020-07-30 words: 2863 flesch: 40 summary: So far, there are no specific studies using biomarkers to predict the risk of deterioration among COVID-19 ESKD patients, although ferritin and LDH have been found in many studies to be associated with severe illness and mortality in COVID-19 [4, 5] . During the previous 2003 SARS-CoV outbreak, dialysis patients were noted to have persistent viral shedding of up to 8 weeks [12] . keywords: case; covid-19; day; dialysis; disease; patients; pcr cache: cord-284979-lyt98od1.txt plain text: cord-284979-lyt98od1.txt item: #1330 of 2876 id: cord-284983-xvtkso79 author: Vigiola Cruz, Mariana title: Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital date: 2020-05-26 words: 3947 flesch: 35 summary: The controversy of placement of peritoneal dialysis catheters Comparison of early mechanical and infective complications in first time blind, bedside, midline percutaneous Tenckhoff Catheter insertion with ultra-short break-in period in diabetics and non-diabetics: setting new standards Infrastructure requirements for an urgent-start peritoneal dialysis program Urgent-start peritoneal dialysis: a chance for a new beginning Effect of prior abdominal surgery, peritonitis, and adhesions on catheter function and longterm outcome on peritoneal dialysis Operationalizing telehealth for home dialysis patients in the United States Minimizing the risk of COVID-19 among patients on dialysis On the frontline of the COVID-19 outbreak: keeping patients on long-term dialysis safe Acute renal failure in critically ill patients: a multinational, multicenter study COVID-19 and the inpatient dialysis unit: managing resources during contingency planning pre-crisis Acute kidney injury in critically Ill patients: a prospective randomized study of tidal peritoneal dialysis versus continuous renal replacement therapy Use of peritoneal dialysis in AKI: a systematic review Urgent-start dialysis: comparison of complications and outcomes between peritoneal dialysis and haemodialysis A global overview of the impact of peritoneal dialysis first or favored policies: an opinion Economic evaluation of urgent-start peritoneal dialysis versus urgent-start hemodialysis in the United States Critically Ill COVID-19 infected patients exhibit increased clot waveform analysis parameters consistent with hypercoagulability Hematological findings and complications of COVID-19 Randomized controlled trials for comparison of laparoscopic versus conventional open catheter placement in peritoneal dialysis patients: a meta-analysis What is the appropriate use of laparoscopy over open procedures in the current COVID-19 climate? Laparoscopy at all costs? keywords: bedside; catheter; covid-19; dialysis; icu; kidney; patients; placement; procedure cache: cord-284983-xvtkso79.txt plain text: cord-284983-xvtkso79.txt item: #1331 of 2876 id: cord-284995-8lyr3gs4 author: Fiorina, Laurent title: COVID-19 et troubles du rythme date: 2020-10-02 words: 1416 flesch: 46 summary: L'embolie pulmonaire (EP) a été rapportée comme une complication fréquente de la COVID-19 présente jusqu'à 13.5% des patients admis en soins intensifs et ceci malgré une anticoagulation préventive standard [23] . Plus récemment une étude portant sur les IRM cardiaques réalisées à des patients convalescents (après un temps médian de 71 jours) a retrouvé des anomalies dans 78% des cas et des signes de processus inflammatoire myocardique encore en cours dans 60% des cas et ce indépendamment de la sévérité initiale de la maladie keywords: covid-19; dans; des; patients; troubles cache: cord-284995-8lyr3gs4.txt plain text: cord-284995-8lyr3gs4.txt item: #1332 of 2876 id: cord-285226-4ydvjmr3 author: Sekhar, Laligam N. title: The Future of Skull Base Surgery: A View Through Tinted Glasses date: 2020-06-27 words: 3711 flesch: 39 summary: However, the essential requirements for skull base surgeons remain unchanged, namely: knowledge, attention to details, technical skill, innovation, judgement, and compassion. However, the essential 28 requirements for skull base surgeons remain unchanged, namely: knowledge, 29 attention to details, technical skill, innovation, judgement, and compassion. keywords: base; care; future; patients; robotics; robots; skull; surgeons; surgery; use cache: cord-285226-4ydvjmr3.txt plain text: cord-285226-4ydvjmr3.txt item: #1333 of 2876 id: cord-285291-pep4opiq author: Remy, Kenneth E. title: Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists* date: 2020-04-29 words: 7169 flesch: 29 summary: Part 2: Treatment Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report Treatment of acute pulmonary embolism: Update on newer pharmacologic and interventional strategies guidelines for management of venous thromboembolism: Prophylaxis for hospitalized and nonhospitalized medical patients Clinical Guidelines Committee of the American College of Physicians: Venous thromboembolism prophylaxis in hospitalized patients: A clinical practice guideline from the American College of Physicians Diagnosis of gastrointestinal bleeding: A practical guide for clinicians PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group: Effect of stress ulcer prophylaxis with proton pump inhibitors vs histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation: The PEPTIC randomized clinical trial Hyperglycemic crises in adult patients with diabetes Hyperosmolar hyperglycemic state: A historic review of the clinical presentation, diagnosis, and treatment Acute kidney injury enhances outcome prediction ability of sequential organ failure assessment score in critically ill patients Acute renal impairment in coronavirus-associated severe acute respiratory syndrome SMART Investigators and the Pragmatic Critical Care Research Group: Balanced crystalloids versus saline in critically ill adults Delirium in the critically ill patient Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU ICU delirium -a diagnostic and therapeutic challenge in the intensive care unit Sedation and delirium in the intensive care unit Incidence and prevalence of pressure injuries in adult intensive care patients: A systematic review and meta-analysis Risk factors for pressure injury development in critically ill patients in the intensive care unit: A systematic review protocol ICU-acquired weakness and recovery from critical illness Critical illness polyneuropathy and myopathy: A major cause of muscle weakness and paralysis Critical illness myopathy and neuropathy Pressure injury risk factors in adult critical care patients: A review of the literature Effectiveness of pressure ulcer prevention strategies for adult patients in intensive care units: A systematic review Treatment of pressure ulcers: A systematic review Management of acute alcohol withdrawal syndrome in critically ill patients Approach to the complicated alcohol withdrawal patient The use of dexmedetomidine as an adjuvant to benzodiazepine-based therapy to decrease the severity of delirium in alcohol withdrawal in adult intensive care unit patients: A systematic review Proxy decision making for incompetent patients. Acute decompensated heart failure (ADHF) is one of the main causes of respiratory distress in adult patients requiring the ICU (99) . keywords: acute; adults; care; covid-19; disease; distress; failure; heart; icu; management; mortality; patients; pressure; sedation; syndrome; treatment; trial; use; ventilation cache: cord-285291-pep4opiq.txt plain text: cord-285291-pep4opiq.txt item: #1334 of 2876 id: cord-285298-r7p44wpe author: Parsonage, William A. title: CSANZ Position Statement on the Evaluation of Patients Presenting With Suspected Acute Coronary Syndromes During the COVID-19 Pandemic # date: 2020-05-21 words: 2142 flesch: 37 summary: Intermediate risk patients who cannot be re-stratified as low risk by the criteria above should continue to be managed according to the existing 2016 Australian Clinical Guidelines for the Management of Acute Coronary Syndromes [1] . This proportion is unlikely to fall and may increase if lower risk patients are disproportionately discouraged from presenting. keywords: cardiac; chest; patients; risk; troponin cache: cord-285298-r7p44wpe.txt plain text: cord-285298-r7p44wpe.txt item: #1335 of 2876 id: cord-285354-bp2dozzg author: Costanzi, Andrea title: In response to: Surgery in the COVID-19 phase 2 Italian scenario: Lessons learned in Northern Italy spoke hospitals date: 2020-07-01 words: 1313 flesch: 48 summary: Nevertheless, after this simplified view of war-time medicine that required our availability in spoke hospitals to turn into COVID doctors, we feel that more planning is required to have the right specialists for COVID patients and to manage a second wave of the pandemic not as unprepared as we did. Minimally invasive surgery was considered a luxury in COVID patients. keywords: care; hospitals; patients; surgery cache: cord-285354-bp2dozzg.txt plain text: cord-285354-bp2dozzg.txt item: #1336 of 2876 id: cord-285360-svczr721 author: Ganesh, Aravind title: Ignorance is not bliss: managing uncertainty in acute stroke treatment in the COVID-19 era date: 2020-10-31 words: 1609 flesch: 25 summary: Recognizing the added risks of treatment delays or misses in these times, we may adopt a lower threshold for direct-to-mothership paradigms that bring stroke patients directly to comprehensive stroke centers to minimize blind spots. Prehospital triage of acute stroke patients during the COVID-19 pandemic Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations keywords: covid-19; information; pandemic; patient; stroke; treatment cache: cord-285360-svczr721.txt plain text: cord-285360-svczr721.txt item: #1337 of 2876 id: cord-285414-vd2d7db2 author: Yu, Qian title: Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients date: 2020-04-27 words: 3087 flesch: 44 summary: This finding is of significant clinical implications, not only in providing us a simpler way to identify high risk patients on CT, but also has potential to extend to chest radiographs, where upper lobe consolidations are easy to be perceived. The finding provided us a simpler way to identify high risk patients on CT that the elder with large consolidation in upper lungs should be paid more attention during the treatment of COVID-19. keywords: admission; clinical; covid-19; endpoints; patients; study cache: cord-285414-vd2d7db2.txt plain text: cord-285414-vd2d7db2.txt item: #1338 of 2876 id: cord-285467-uxfk6k3c author: Ragni, Enrico title: Management of osteoarthritis during COVID‐19 pandemic date: 2020-05-21 words: 7081 flesch: 25 summary: OA patients often show a large array of concomitant pathologies such as diabetes, inflammation and cardiovascular diseases that are again shared with COVID‐19 patients and may therefore increase complications. Predisposing comorbidities in OA patients At the moment, no studies have investigated a potential relationship between respiratory viral infections and the development of OA, as described for parainfluenza and coronavirus and the incidence of rheumatoid arthritis (30) . keywords: article; copyright; covid-19; disease; drugs; infection; nsaids; opioids; osteoarthritis; patients; pneumonia; rights; risk; sars; treatment; use cache: cord-285467-uxfk6k3c.txt plain text: cord-285467-uxfk6k3c.txt item: #1339 of 2876 id: cord-285469-b61y9ezi author: Hernández-Fernández, Francisco title: Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description date: 2020-07-09 words: 7016 flesch: 37 summary: Although our observed incidence of CVD in COVID-19 patients is slightly lower than reported (Mao et al., 2020) , deferred medical care, and the lower number of patients admitted with lacunar infarctions could have underestimated the actual incidence of CVD. Bivariates studies were designed to contrast the main variables among CVD patients, between ischaemic/haemorrhagic subtypes within the COVID-19 group, and to assess clinical prognosis. keywords: brain; cases; cerebral; cov-2; covid-19; cvd; et al; findings; infection; patients; sars; stroke; study cache: cord-285469-b61y9ezi.txt plain text: cord-285469-b61y9ezi.txt item: #1340 of 2876 id: cord-285472-cj5r3xt1 author: Kaur, Parminder title: Acute upper limb ischemia in a patient with COVID-19 date: 2020-05-13 words: 1119 flesch: 33 summary: WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19 Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV Will complement inhibition be the new target in treating COVID-19 related systemic thrombosis? The prevalence of thrombosis among patients with COVID-19 is not fully established as most of the literature focus on hospitalized patients who are more likely to have comorbid conditions than individuals with asymptomatic or mild disease burden. keywords: coronavirus; covid-19; disease; patients cache: cord-285472-cj5r3xt1.txt plain text: cord-285472-cj5r3xt1.txt item: #1341 of 2876 id: cord-285588-ug7upa3r author: Ajibade, Ayomikun title: Telemedicine in cardiovascular surgery during COVID‐19 pandemic: A systematic review and our experience date: 2020-08-16 words: 4143 flesch: 29 summary: The FIT@Home study conducted a 12-week home-based exercise training program for cardiac surgery patients, where patient status was tracked using a remote heart-rate monitor and regular telephone support. Combinations of regular virtual consultations and remote monitoring of clinical parameters are feasible for cardiac surgery patients and would be useful to assess and triage before surgery. keywords: cardiac; covid-19; health; heart; monitoring; pandemic; patients; surgery; telemedicine; use cache: cord-285588-ug7upa3r.txt plain text: cord-285588-ug7upa3r.txt item: #1342 of 2876 id: cord-285732-xew5ar1e author: Eperjesiova, Bianka title: Spontaneous Pneumomediastinum/Pneumothorax in Patients With COVID-19 date: 2020-07-03 words: 801 flesch: 40 summary: Spontaneous air leak is the travel of free air following distended ruptured alveoli via peribronchovascular sheaths into the mediastinum or the pleural space [1] . Radiological evidence of spontaneous air leak was found in seven patients (incidence 0.72%) with event onset 9±9 days (mean±SD) from COVID-19 symptom onset and 6±8 days (mean±SD) from admission. keywords: air; patients cache: cord-285732-xew5ar1e.txt plain text: cord-285732-xew5ar1e.txt item: #1343 of 2876 id: cord-285755-zblitbo0 author: Zhang, F. title: Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study date: 2020-03-24 words: 3071 flesch: 37 summary: Studies focused on cardiac injury in COVID-19 patients are scarce. Short-term prognosis of COVID-19 patients are discrepancy and in-hospital mortality risk are high in severe cases[1] keywords: cardiac; covid-19; ctni; disease; hospital; injury; patients cache: cord-285755-zblitbo0.txt plain text: cord-285755-zblitbo0.txt item: #1344 of 2876 id: cord-285757-fiqx4tll author: Mäkelä, M. J. title: Lack of Induction by Rhinoviruses of Systemic Type I Interferon Production or Enhanced MxA Protein Expression During the Common Cold date: 1999 words: 1826 flesch: 46 summary: 285757 cord_uid: fiqx4tll To study whether MxA protein expression is systemically upregulated during rhinovirus infection, blood specimens were collected from 40 patients with common cold and MxA expression in mononuclear cells analyzed by flow cytometry. Although we did not find IFN or clearly induced MxA protein expression in the peripheral blood of any subject with rhinovirus infection, we cannot rule out the possibly significant role of IFN in local epithelial response against the virus. keywords: ifn; mxa; patients; rhinovirus cache: cord-285757-fiqx4tll.txt plain text: cord-285757-fiqx4tll.txt item: #1345 of 2876 id: cord-285772-4xt4anq5 author: Huang, Rui title: Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study date: 2020-05-08 words: 3382 flesch: 56 summary: The age of severe patients was comparable with non-severe patients (median age 49.0 yr vs. 44.0 yr, P = 0.066) and the BMI index of severe patients was higher than non-severe patients (median BMI, 26.4 kg/m 2 vs. 24.2 kg/m 2 , P = 0.004). [ Compared to non-severe patients, severe patients presented higher percentage of shortness of breath (7.3% vs. 26.1%, P = 0.004), lower lymphocytes (median 0.8 ×10 9 /L vs. 1.2×10 9 /L, P<0.001) and albumin (ALB) levels (median 38.1 g/L vs. 41.1 g/L, P = 0.002). keywords: clinical; coronavirus; covid-19; patients; severe; study; wuhan cache: cord-285772-4xt4anq5.txt plain text: cord-285772-4xt4anq5.txt item: #1346 of 2876 id: cord-285818-eh12luma author: Louis, Shreya title: Continuous Electroencephalography Characteristics and Acute Symptomatic Seizures in COVID-19 Patients date: 2020-08-26 words: 3434 flesch: 46 summary: This high percentage of epileptiform abnormalities (EAs) in a specific brain region in COVID-19 patients behooves the question if this is a potential epileptic effect from the SARS-CoV-2 infection or if this is a limitation with the EEG requisition method itself; since patients did not receive the minimum required 21-electrode clinical EEG recommended by American Clinical Neurophysiological Society ACNS) (Sinha et al. 2016) . Since the primary aim was to characterize the cEEG findings of COVID-19 patients, we did not include patients with clinical concerns for COVID-19 disease who tested negative. keywords: ceeg; covid-19; findings; patients; seizures cache: cord-285818-eh12luma.txt plain text: cord-285818-eh12luma.txt item: #1347 of 2876 id: cord-285867-61y4aamj author: Kichloo, Asim title: Atezolizumab-Induced Bell’s Palsy in a Patient With Small Cell Lung Cancer date: 2020-10-13 words: 1978 flesch: 38 summary: Cancer immunotherapy: harnessing the immune system to battle cancer Immune checkpoint inhibitors: recent progress and potential biomarkers PD-1 pathway inhibitors: immunooncology agents for restoring antitumor immune responses Facial palsy induced by checkpoint blockade: a single center retrospective study Immunotherapy for lung cancer Fatal toxic effects associated with immune checkpoint inhibitors: a systematic review and meta-analysis Clinical characteristics and treatment of immune-related adverse events of immune checkpoint inhibitors Multifocal radiculoneuropathy during ipilimumab treatment of melanoma Checkpoint inhibitor immune therapy: systemic indications and ophthalmic side effects Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology Clinical Practice Guideline Autoimmune Bell's palsy following immunotherapy for metastatic melanoma: a report of 2 cases Paraneoplastic neurological syndromes in lung cancer patients with or without onconeural antibodies All authors have contributed equally to the study. [3] [4] [5] Neurotoxic complications as a result of immune checkpoint inhibitor therapies occur in roughly 1% of patients, according to a meta-analysis by Wang et al. 6 There are multiple hypotheses as to why immune checkpoint inhibitors may cause neurotoxic irAE. keywords: atezolizumab; checkpoint; immune; immunotherapy; palsy; patient cache: cord-285867-61y4aamj.txt plain text: cord-285867-61y4aamj.txt item: #1348 of 2876 id: cord-285897-ahysay2l author: Wu, Guangyao title: Development of a Clinical Decision Support System for Severity Risk Prediction and Triage of COVID-19 Patients at Hospital Admission: an International Multicenter Study date: 2020-07-02 words: 3809 flesch: 38 summary: General quarantine and symptomatic treatment at home or mobile hospital can be used for most non-severe patients, while a higher level of care and fast track to the intensive care unit (ICU) is needed for severe patients. There were significant difference for the proportion of severe patients among low, medium, and high-risk groups in the five test datasets (Figure 5 ). keywords: admission; covid-19; features; hospital; illness; laboratory; model; patients; risk cache: cord-285897-ahysay2l.txt plain text: cord-285897-ahysay2l.txt item: #1349 of 2876 id: cord-285907-xoiju5ub author: Chang, Shang-Miao title: Comparative study of patients with and without SARS WHO fulfilled the WHO SARS case definition date: 2005-05-31 words: 3610 flesch: 55 summary: SARS patients with an initially normal chest X-ray study developed infiltrates at a mean of 5 ± 3.44 days after onset of fever (21/22 SARS vs. 0/5 non-SARS). Being a health care worker and visiting a hospital where SARS patients had been treated were risk factors for SARS. keywords: chest; disease; fever; non; patients; sars cache: cord-285907-xoiju5ub.txt plain text: cord-285907-xoiju5ub.txt item: #1350 of 2876 id: cord-286096-h275nner author: Huijskens, Elisabeth G. W. title: Viral and bacterial aetiology of community‐acquired pneumonia in adults date: 2012-08-22 words: 3715 flesch: 42 summary: Year-round inclusion is important to cover the complete spectrum of respiratory virus infections, because several viruses are known to be found only in particular months of the year. InfA has been found as the second most frequent pathogen in CAP patients and the most common viral pathogen in all the age groups. keywords: antigen; community; pathogens; patients; pneumoniae; samples; sputum; viruses cache: cord-286096-h275nner.txt plain text: cord-286096-h275nner.txt item: #1351 of 2876 id: cord-286227-foeb0g7u author: Potekaev, Nikolai N. title: Clinical characteristics of dermatologic manifestations of COVID‐19 infection: case series of 15 patients, review of literature, and proposed etiological classification date: 2020-07-03 words: 1115 flesch: 35 summary: key: cord-286227-foeb0g7u authors: Potekaev, Nikolai N.; Zhukova, Olga V.; Protsenko, Denis N.; Demina, Olga M.; Khlystova, Elena A.; Bogin, Vlad title: Clinical characteristics of dermatologic manifestations of COVID‐19 infection: case series of 15 patients, review of literature, and proposed etiological classification date: 2020-07-03 journal: Int J Dermatol DOI: 10.1111/ijd.15030 sha: doc_id: 286227 cord_uid: foeb0g7u nan Presently, the exact dermatologic manifestations of COVID-19 infection, its characteristics, prevalence, temporal relationship to other clinical findings, and severity of underlying illness are still being evaluated. They excluded 60 of 148 patients from their study as they were taking new medications prior to developing symptoms of COVID-19 infection, indicating that a drug allergic reaction could not be excluded as a cause of their dermatologic presentation. keywords: covid-19; patient; year cache: cord-286227-foeb0g7u.txt plain text: cord-286227-foeb0g7u.txt item: #1352 of 2876 id: cord-286237-x6dr6rsh author: Maes, Bastiaan title: Treatment of severely ill COVID-19 patients with anti-interleukin drugs (COV-AID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-03 words: 11261 flesch: 42 summary: Ethical and legal aspects The study will be conducted cfr the latest version of the ICH E6 (R2) GCP guidelines, creating a standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical studies that provides assurance that the data and reported results are accurate and that the rights, integrity and confidentiality of study subjects are protected. Monitoring services will consist of the following (non-exhaustive list): -review of informed consents and the followed process -check on recruitment status -checking for protocol deviations/violations -checking GCP compatibility -check on safety reporting compliance -IMP handling and storage -review of study data … This study can be inspected at any time by regulatory agencies during or after completion of the study. keywords: anakinra; blood; care; covid-19; cytokine; data; days; hospital; il-1; il-6; improvement; injection; investigator; patients; siltuximab; study; subject; time; tocilizumab; treatment; trial; use cache: cord-286237-x6dr6rsh.txt plain text: cord-286237-x6dr6rsh.txt item: #1353 of 2876 id: cord-286293-f5qg7vcz author: Ullah, Waqas title: COVID-19 complicated by Acute Pulmonary Embolism and Right-Sided Heart Failure date: 2020-04-17 words: 1096 flesch: 39 summary: In the present case, the patient had elevated CRP and d-dimer levels with no other risk factor for pulmonary embolism, indicating COVID-19 related hypercoagulable state as possible etiology for thrombosis in the pulmonary vasculature. • To be able to make a differential diagnosis of pulmonary embolism in patients with COVID-19 with sudden onset of dyspnea and hypoxemia. keywords: covid-19; disease; embolism; patients cache: cord-286293-f5qg7vcz.txt plain text: cord-286293-f5qg7vcz.txt item: #1354 of 2876 id: cord-286334-d9v5xtx7 author: Li, Rui title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 words: 12986 flesch: 42 summary: Several strategies may help reduce the threat of AIV to equines, including reducing exposure of equines to poultry, birds, and other hosts of IAV, especially animals with clinical signs of influenza virus infection; monitoring AIV prevalence in domestic poultry around equines and routinely vaccinating domestic poultry with AIV vaccines; vaccinating susceptible equines with EI vaccines, especially farming equines in close contact with domestic poultry; and monitoring the prevalence of multiple AIV subtypes in equines, not merely that of those restricted to H3N8 subtype. 5 Low humidity and temperature increased the stability of influenza virus in aerosols and on surfaces. keywords: analysis; bacterial; cases; china; data; ecmo; epidemic; fig; genotype; hbv; hcv; hepatitis; hubei; human; infection; influenza; novel; patients; pneumonia; sequences; sequencing; study; subtype; transmission; virus cache: cord-286334-d9v5xtx7.txt plain text: cord-286334-d9v5xtx7.txt item: #1355 of 2876 id: cord-286403-gdkwabcj author: Rosovsky, Rachel P. title: Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium date: 2020-08-27 words: 2366 flesch: 29 summary: Existing hospital transfer policies for PE patients, regardless of COVID-19 status, should incorporate the following: There must be a well-defined clinical benefit or resources or services that are not available at the sending hospital, such as intensive care unit care, endovascular intervention or surgical services, ECMO, and neurosurgical services. There is emerging evidence that COVID-19 infected patients are prone to thrombosis and pulmonary embolism (PE). keywords: care; covid-19; embolism; patients; pert; treatment cache: cord-286403-gdkwabcj.txt plain text: cord-286403-gdkwabcj.txt item: #1356 of 2876 id: cord-286418-9ho5fg3h author: Jenkins, Ian title: Lessons from Walking the Medical Distancing Tightrope date: 2020-05-28 words: 2625 flesch: 42 summary: Patient care and education at the University of California, San Diego Health System had to change just as dramatically. At all levels, physicians and administrators worried that the distancing pendulum had swung too far away from direct patient care. keywords: care; covid; distancing; experience; hcw; health; hospital; patient; risk cache: cord-286418-9ho5fg3h.txt plain text: cord-286418-9ho5fg3h.txt item: #1357 of 2876 id: cord-286477-0euaaspo author: Li, Xiaochen title: Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan date: 2020-04-12 words: 3244 flesch: 51 summary: Severe patients treated with corticosteroids had higher LDH level compared 283 with severe patients without corticosteroid use pre-admission (P<0.05). Cox proportional hazard regression model was used for survival analysis in severe patients. keywords: admission; cases; covid-19; data; patients; sars; study cache: cord-286477-0euaaspo.txt plain text: cord-286477-0euaaspo.txt item: #1358 of 2876 id: cord-286525-0354438s author: Lee, Todd C. title: Tocilizumab versus the covid19 tempest: all’s well that ends well or much ado about nothing? date: 2020-09-29 words: 1440 flesch: 35 summary: As such, the tocilizumab group was further along in the illness trajectory with a median of One of the unexpected findings from this study was an observed lack of benefit from steroids in contrast to the RECOVERY randomized controlled trial results [4] or a recent meta-analysis of steroid trials in critically ill patients. The phase III COVACTA trial (NCT04317092) found tocilizumab did not reduce mortality in hospitalized patients with severe COVID-19 pneumonia keywords: covid-19; patients; tocilizumab; trial cache: cord-286525-0354438s.txt plain text: cord-286525-0354438s.txt item: #1359 of 2876 id: cord-286574-t9z2ynt5 author: None title: Speaker presentations date: 2017-09-30 words: 14868 flesch: 37 summary: Increased mortality and morbidity in resistant infections is due to treatment failure of antibiotic therapy which is associated with bacterial fitness, greater severity of underlying illness, delays in initiating effective therapy and lack of effective therapy (Friedman et al. 2016) . In this study, emticitrabine/tenofovir disoproxil fumarate (FTC/TDF or Truvada ® ) safely achieved a 44% per-protocol reduction in new HIV infections. keywords: amr; antibiotics; care; clones; colistin; control; countries; development; disease; drug; gram; health; hiv; impact; infection; mortality; mrsa; new; patients; pneumonia; prep; resistance; risk; sfts; species; strains; studies; testing; therapy; time; treatment; use cache: cord-286574-t9z2ynt5.txt plain text: cord-286574-t9z2ynt5.txt item: #1360 of 2876 id: cord-286607-5i406twr author: Esposito, Susanna title: The Gut Microbiota-Host Partnership as a Potential Driver of Kawasaki Syndrome date: 2019-04-05 words: 6229 flesch: 14 summary: The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease Detection of multiple superantigen genes in stools of patients with Kawasaki disease Mycoplasma pneumoniae infection in patients with Kawasaki disease Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan Effects of natural and chemically defined nutrients on Candida albicans water-soluble fraction (CAWS) vasculitis in mice Neutrophil activation and arteritis induced by C. albicans water-soluble mannoprotein-beta-glucan complex (CAWS) Induction of coronary arteritis with administration of CAWS (Candida albicans water-soluble fraction) depending on mouse strains Kawasaki disease may be a hyperimmune reaction of genetically susceptible children to variants of normal environmental flora The throat flora and its mitogenic activity in patients with Kawasaki disease Microbiologic studies on the small intestine in Kawasaki disease Immunohistochemical studies on small intestinal mucosa in Kawasakidisease Kawasaki disease and the pediatric gastroenterologist: a diagnostic challenge Characteristic role of intestinal microflora in Kawasaki disease The starting lineup: key microbial players in intestinal immunity and homeostasis Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide Anti-inflammatory effect of Lactobacillus casei on Shigellainfected human intestinal epithelial cells Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease Characterization of the gut microbiota of Kawasaki disease patients by metagenomic analysis Altered mucosal microbiome diversity and disease severity in Sjögren syndrome Alterations of the human gut microbiome in liver cirrhosis Eubiosis and dysbiosis: the two sides of the microbiota Further investigations of the intestinal microflora in larger cohorts of KS patients will provide clues to disentangle the pathogenesis of this disease and probably indicate disease-modifying agents or more rational KS-specific therapies. keywords: acute; children; disease; gut; human; immune; kawasaki; microbiota; patients; role; syndrome cache: cord-286607-5i406twr.txt plain text: cord-286607-5i406twr.txt item: #1361 of 2876 id: cord-286611-e1i1wemo author: Benziger, Catherine P. title: The Telehealth Ten: A Guide for a Patient-Assisted Virtual Physical Exam date: 2020-07-18 words: 1782 flesch: 57 summary: Telemedicine for Covid-19 Effect of self-monitoring and medication selftitration on systolic blood pressure in hypertensive patients at high risk of cardiovascular disease: the TASMIN-SR randomized clinical trial Self-monitoring of Blood Pressure in Patients With Hypertension-Related Multi-morbidity: Systematic Review and Individual Patient Data Meta-analysis Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial Images in clinical medicine. This evaluation can be enhanced using digital devices, such as wearables for heart rate and electrocardiogram (ECG) and home monitoring devices (scale, blood pressure cuff, and pulse oximeter), which are potentially available to patients. keywords: clue; heart; patients; step; telehealth cache: cord-286611-e1i1wemo.txt plain text: cord-286611-e1i1wemo.txt item: #1362 of 2876 id: cord-286638-bqxyb61p author: Singh, Awadhesh Kumar title: Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations date: 2020-04-09 words: 4831 flesch: 40 summary: Based on these findings and acknowledging the higher morbidities and mortality associated with comorbidities, researchers have recently proposed that the course of treatment and prognosis of COVID-19 should be stratified based on the absence or presence of co-morbidities in to type A, B and C. While Type A represents COVID-19 patients with pneumonia with no comorbidities, Type B denotes COVID-19 pneumonia with comorbidities; and Type C denotes COVID-19 pneumonia with multi-organ dysfunction [30] . High prevalence of diabetes makes it an important comorbidity in patients with COVID-19. keywords: coronavirus; covid-19; diabetes; disease; glucose; infection; patients; pneumonia; risk; sars; study cache: cord-286638-bqxyb61p.txt plain text: cord-286638-bqxyb61p.txt item: #1363 of 2876 id: cord-286683-mettlmhz author: Ortiz-Prado, Esteban title: Clinical, molecular and epidemiological characterization of the SARS-CoV2 virus and the Coronavirus disease 2019 (COVID-19), a comprehensive literature review date: 2020-05-30 words: 13331 flesch: 37 summary: medRxiv Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Temporal dynamics in viral shedding and transmissibility of COVID-19 Presumed asymptomatic carrier transmission of COVID-19 Potential presymptomatic transmission of SARS-CoV-2 Interferon-stimulated genes and their antiviral effector functions RIG-I in RNA virus recognition RNA recognition and signal transduction by RIG-I-like receptors Recognition of viral single-stranded RNA by Toll-like receptors Mechanisms of innate immune evasion in re-emerging RNA viruses Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections Immunopathogenesis of coronavirus infections: implications for SARS Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology Middle East respiratory syndrome Interaction of SARS and MERS coronaviruses with the antiviral interferon response SARS and MERS: recent insights into emerging coronaviruses Dysregulation of immune response in patients with COVID-19 in Wuhan Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of the macrophage activation syndrome: Re-analysis of a prior Phase III trial A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19) Effects of chloroquine on viral infections: an old drug against today's diseases Chloroquine is a potent inhibitor of SARS coronavirus infection and spread In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Baricitinib as potential treatment for 2019-nCoV acute respiratory disease COVID-19: consider cytokine storm syndromes and immunosuppression. Three recent examples of these viral jumps include SARS CoV, MERS-CoV and SARS CoV-2 virus. keywords: acute; cases; cells; china; clinical; coronavirus; cov-2; covid-19; disease; health; human; infection; influenza; mers; ncov; novel; novel coronavirus; patients; pneumonia; protein; r n; responses; sars; study; syndrome; treatment; use; vaccine; wuhan cache: cord-286683-mettlmhz.txt plain text: cord-286683-mettlmhz.txt item: #1364 of 2876 id: cord-286743-z0e5arlm author: Langer-Gould, Annette title: Early Identification of COVID-19 Cytokine Storm and Treatment with Anakinra or Tocilizumab date: 2020-08-06 words: 4303 flesch: 36 summary: Anakinra, a short-acting IL-1 receptor antagonist is the preferred treatment for severe forms of cytokine storm for patients with underlying conditions other than COVID-19, but its use was not reported for COVID-19 patients in China. In many clinical settings, tocilizumab and, to a lesser extent anakinra, are being used to treat COVID-19 patients with very little information to guide patient selection, dosing or monitoring of treatment response. keywords: anakinra; corticosteroids; covid19; patients; tocilizumab; treatment cache: cord-286743-z0e5arlm.txt plain text: cord-286743-z0e5arlm.txt item: #1365 of 2876 id: cord-286843-8qh1pblc author: Quah, Jessica title: Impact of microbial Aetiology on mortality in severe community-acquired pneumonia date: 2018-09-04 words: 4065 flesch: 34 summary: The immunology of influenza virusassociated bacterial pneumonia Integrated clinical, pathologic, Virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque Kinetics of coinfection with influenza a virus and Streptococcus pneumoniae Etiology of severe communityacquired pneumonia during the 2013 hajj-part of the MERS-CoV surveillance program Clinical and molecular characterization of rhinoviruses a, B, and C in adult patients with pneumonia Human rhinoviruses and severe respiratory infections: is it possible to identify at-risk patients early? viral pneumonia and acute respiratory distress syndrome Burden of acute respiratory disease of epidemic and pandemic potential in the WHO eastern Mediterranean region: a literature review Global threat of animal influenza viruses of zoonotic concern: then and now Surviving Sepsis campaign: international guidelines for Management of Severe Sepsis and Septic Shock Global and local epidemiology of communityacquired pneumonia: the experience of the CAPNETZ network Global changes in the epidemiology of community-acquired pneumonia Community-acquired pneumonia requiring hospitalization among U.S Adults Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia Empirical use of fluoroquinolones improves the survival of critically ill patients with tuberculosis mimicking severe pneumonia Impact of antibiotic therapy in severe community-acquired pneumonia: data from the Infauci study Predictive factors of mortality in severe community-acquired pneumonia: a model with data on the first 24h of ICU admission Viral infection in patients with severe pneumonia requiring intensive care unit admission Etiology of severe pneumonia in the very elderly Assessment of prognosis in patients with community-acquired pneumonia who require mechanical ventilation The authors would like to thank the following: Ms. Carmen Kam, the resident biostatistician for verification of the study statistical analysis; nurses Ms. Wang Xi Qin, Ms. Goh Yuan Xuan, Ms. Lim Qian Ru for assistance in data collection; senior medical technologist Ms. Heng Ying Xuan, Ms. Lee Hui Zi for assistance in performance of PCR tests; Dr. Tay Tunn Ren for her tutelage in manuscript writing. Polymerase chain reaction Etiology and outcome of severe community acquired pneumonia in immunocompetent adults Etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in Norway Epidemiology of community-acquired respiratory tract infections in adults The intensive care global study on severe acute respiratory infection (IC-GLOSSARI): a multicenter, multinational, 14-day inception cohort study Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia Molecular diagnosis of respiratory viruses The FilmArray® respiratory panel: an automated, broadly multiplexed molecular test for the rapid and accurate detection of respiratory pathogens Rapid viral diagnosis for acute febrile respiratory illness in children in the emergency department Clinical utility of on-demand multiplex respiratory pathogen testing among adult outpatients Burden of respiratory viruses in patients with acute respiratory failure Community-acquired polymicrobial pneumonia in the intensive care unit: aetiology and prognosis Clinical characteristics and outcomes in hospitalized patients with respiratory viral co-infection during the 2009 H1N1 influenza pandemic Management of severe communityacquired pneumonia: a survey on the attitudes of 468 physicians in Iberia and South America Clinical practice of respiratory virus diagnostics in critically ill patients with a suspected pneumonia: a prospective observational study Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the Management of Community-Acquired Pneumonia in adults Acute management and long-term survival among subjects with severe Middle East respiratory syndrome coronavirus pneumonia and ARDS Virus-induced acute respiratory distress syndrome: epidemiology, management and outcome Influenza a (H1N1) vs non-H1N1 ARDS: analysis of clinical course A prospective one-year microbiologic survey of combined pneumonia and respiratory failure The use of polymerase chain reaction amplification for the detection of viruses and Bacteria in severe communityacquired pneumonia keywords: cap; hospital; infections; mortality; pathogens; patients; pneumonia; study; viruses cache: cord-286843-8qh1pblc.txt plain text: cord-286843-8qh1pblc.txt item: #1366 of 2876 id: cord-286853-9gbel3pq author: Kim, Jiwon title: Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 date: 2020-10-27 words: 2131 flesch: 24 summary: key: cord-286853-9gbel3pq authors: Kim, Jiwon; Volodarskiy, Alexander; Sultana, Razia; Pollie, Meridith P.; Yum, Brian; Nambiar, Lakshmi; Tafreshi, Romina; Mitlak, Hannah W.; RoyChoudhury, Arindam; Horn, Evelyn M.; Hriljac, Ingrid; Narula, Nupoor; Kim, Sijun; Ndhlovu, Lishomwa; Goyal, Parag; Safford, Monika M.; Shaw, Leslee; Devereux, Richard B.; Weinsaft, Jonathan W. title: Prognostic Utility of Right Ventricular Remodeling Over Conventional Risk Stratification in Patients With COVID-19 date: 2020-10-27 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2020.08.066 sha: doc_id: 286853 cord_uid: 9gbel3pq BACKGROUND: Coronavirus disease 2019 (COVID-19) is a growing pandemic that confers augmented risk for right ventricular (RV) dysfunction and dilation; the prognostic utility of adverse RV remodeling in COVID-19 patients is uncertain. Whereas this study supports premise of our study, limited sample size and laboratory data prohibited assessment of whether the predictive utility of adverse RV remodeling dysfunction was additive to that of biomarker derived prognostic markers, which was a focus of the current research. keywords: covid-19; dilation; dysfunction; patients; remodeling; study cache: cord-286853-9gbel3pq.txt plain text: cord-286853-9gbel3pq.txt item: #1367 of 2876 id: cord-287048-5od0ssyk author: Areaux, Raymond G. title: Your eye doctor will virtually see you now: synchronous patient-to-provider virtual visits in pediatric tele-ophthalmology date: 2020-08-03 words: 3046 flesch: 38 summary: The arrival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or COVID-19) obliterated these barriers as executive orders forced patients, providers, and payors to adapt to an unprecedented, nearly instant, and enormous demand for virtual care. Prior to COVID-19, providers would identify patients during an office visit who might benefit from follow-up via SPPVV. keywords: care; covid-19; ophthalmology; patient; provider; sppvv; telemedicine; visits cache: cord-287048-5od0ssyk.txt plain text: cord-287048-5od0ssyk.txt item: #1368 of 2876 id: cord-287102-o19uwryp author: Amit, Moran title: Clinical Course and Outcomes of Severe Covid-19: A National Scale Study date: 2020-07-18 words: 4185 flesch: 48 summary: The following mortality rates have been found for Covid-19 patients in the ICU for whom outcome data are available (i.e., excluding patients who were still being treated in the ICU at the time of the report): 61% (Lombardy, Italy [2] ), 78% (New York City, NY, USA [4] ), 79% (Wuhan, China [11] ), 57% (Seattle, WA, USA [12] ), 85% (Washington state, USA [13] ), and 67% (China [3] )) Patients who died prior to ICU admission and patients without outcome data were excluded. keywords: age; covid-19; data; days; icu; israel; patients; years cache: cord-287102-o19uwryp.txt plain text: cord-287102-o19uwryp.txt item: #1369 of 2876 id: cord-287117-3v9nyagt author: Monteagudo, Luke Adam title: Continuous Intravenous Anakinra Infusion to Calm the Cytokine Storm in Macrophage Activation Syndrome date: 2020-04-21 words: 4643 flesch: 42 summary: HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis Prognostic factors and outcomes of adults with hemophagocytic lymphohistiocytosis Clinical features of adult patients with secondary hemophagocytic lymphohistiocytosis from causes other than lymphoma: an analysis of treatment outcome and prognostic factors A case of macrophage activation syndrome successfully treated with anakinra Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids Successful treatment of severe paediatric rheumatic diseaseassociated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: case series with 12 patients Benefit of anakinra in treating pediatric secondary hemophagocytic lymphohistiocytosis Successful treatment of cytomegalovirus associated hemophagocytic lymphohistiocytosis with the interleukin 1 inhibitor: anakinra Interleukin 1 receptor antagonist anakinra, intravenous immunoglobulin, and corticosteroids in the management of critically ill adult patients with hemophagocytic lymphohistiocytosis Safe usage of anakinra and dexamethasone to treat refractory hemophagocytic lymphohistiocytosis secondary to acute disseminated histoplasmosis in a patient with HIV/AIDS Hemophagocytic lymphohistiocytosis in an adult kidney transplant recipient successfully treated by plasmapheresis: a case report and review of the literature Enterovirus-associated HLH: addition of anakinra to IVIG and corticosteroids Pharmacokinetics of anakinra in subjects with different levels of renal function Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol Adult haemophagocytic syndrome Clinical features of haemophagocytic syndrome in patients with systemic autoimmune diseases: analysis of 30 cases Causes and significance of markedly elevated serum ferritin levels in an academic medical center How I treat hemophagocytic lymphohistiocytosis in the adult patient Update on the management of systemic juvenile idiopathic arthritis and role of IL-1 and IL-6 inhibition lump or to split in macrophage activation syndrome and hemophagocytic lymphohistiocytosis Intravenous anakinra treatment in a rare case of macrophage activation syndrome presenting as fulminant liver failure Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial COVID-19: consider cytokine storm syndromes and immunosuppression Ms Felicia Jones for administrative support and the fellows involved in the care of these patients. Gram-negative bacteremia might be associated with the length of time patients were on higher doses of anakinra because, in our experience, shorter courses in other patients and/or other diseases treated did not manifest similar problems. keywords: activation; anakinra; levels; mas; patients; syndrome cache: cord-287117-3v9nyagt.txt plain text: cord-287117-3v9nyagt.txt item: #1370 of 2876 id: cord-287161-hqrql1lh author: McGrail, D. E. title: COVID-19 Case Series at UnityPoint Health St. Lukes Hospital in Cedar Rapids, IA date: 2020-07-19 words: 2238 flesch: 44 summary: The most common presenting symptoms in COVID-19 patients were dyspnea (80%), cough (74%), fever (68%), and nausea(35%). In summary, we hope the knowledge gained through this study will help provide further insights into the epidemiological, clinical, laboratory and treatment outcomes of COVID-19 patients hospitalized in a community-based hospital in Iowa. keywords: azithromycin; covid-19; hospital; hydroxychloroquine; patients; ventilation cache: cord-287161-hqrql1lh.txt plain text: cord-287161-hqrql1lh.txt item: #1371 of 2876 id: cord-287210-sars5dmi author: Woo, Patrick C. Y. title: Clinical and Molecular Epidemiological Features of Coronavirus HKU1–Associated Community-Acquired Pneumonia date: 2005-12-01 words: 3384 flesch: 50 summary: key: cord-287210-sars5dmi authors: Woo, Patrick C. Y.; Lau, Susanna K. P.; Tsoi, Hoi-wah; Huang, Yi; Poon, Rosana W. S.; Chu, Chung-ming; Lee, Rodney A.; Luk, Wei-kwang; Wong, Gilman K. M.; Wong, Beatrice H. L.; Cheng, Vincent C. C.; Tang, Bone S. F.; Wu, Alan K. L.; Yung, Raymond W. H.; Chen, Honglin; Guan, Yi; Chan, Kwok-hung; Yuen, Kwok-yung title: Clinical and Molecular Epidemiological Features of Coronavirus HKU1–Associated Community-Acquired Pneumonia date: 2005-12-01 journal: J Infect Dis DOI: 10.1086/497151 sha: doc_id: 287210 cord_uid: sars5dmi BackgroundRecently, we described the discovery of a novel group 2 coronavirus, coronavirus HKU1 (CoV-HKU1), from a patient with pneumonia. NL63 infection in Canada New human coronavirus, HCoV-NL63, associated with severe lower respiratory tract disease in Australia Detection of human coronavirus NL63 in young children with bronchiolitis Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China Molecular epidemiology of the novel coronavirus causes severe acute respiratory syndrome Lung pathology of fatal severe acute respiratory syndrome Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China Viral replication in the nasopharynx is associated with diarrhea in patients with severe acute respiratory syndrome Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Evaluation of reverse transcription-PCR assays for rapid diagnosis of severe acute respiratory syndrome associated with a novel coronavirus Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients Viral loads in clinical specimens and SARS manifestations keywords: community; coronavirus; cov; hku1; patients; pneumonia; pol; sars cache: cord-287210-sars5dmi.txt plain text: cord-287210-sars5dmi.txt item: #1372 of 2876 id: cord-287222-wojyisu0 author: Zhou, Min title: Coronavirus disease 2019 (COVID-19): a clinical update date: 2020-04-02 words: 5692 flesch: 34 summary: Unlike influenza pneumonia, which usually exhibited unilateral GGO and significant solid nodules, only 6% of COVID-19 patients had solid nodules A majority of COVID-19 patients showed normal leucocyte count, and nearly one third had leucopenia keywords: china; clinical; coronavirus; covid-19; disease; infection; novel; patients; plasma; pneumonia; sars; study; syndrome; treatment; ventilation cache: cord-287222-wojyisu0.txt plain text: cord-287222-wojyisu0.txt item: #1373 of 2876 id: cord-287367-1sdt9zz8 author: Andrews, Denise title: Multiplex PCR point of care testing versus routine, laboratory-based testing in the treatment of adults with respiratory tract infections: a quasi-randomised study assessing impact on length of stay and antimicrobial use date: 2017-10-10 words: 6431 flesch: 45 summary: 20% of control arm patients and 24% of intervention arm patients had an RP detected. FilmArray® POC testing occurred on even days of the month (intervention) or routine, laboratory-based RP PCR testing +/− atypical serology on odd days (control). keywords: arm; control; filmarray; intervention; patients; poc; respiratory; results; stay; study; testing; time cache: cord-287367-1sdt9zz8.txt plain text: cord-287367-1sdt9zz8.txt item: #1374 of 2876 id: cord-287373-7xjn05k8 author: Lian, Xin title: Under the coronavirus disease 2019(COVID-19) pandemic circumstance, how to administrate cancer patients with fever during radiotherapy date: 2020-06-05 words: 374 flesch: 36 summary: Scientific and reasonable arrangements for the treatment and strict screen procedure for fever patient will ensure the maximization of the rights and interests of cancer patients. During the covid-19 pandemic, the center has added free online consultation In summary, for cancer patients receiving radiotherapy, especially for lung cancer patients, old age, late disease staging, combined with cardiovascular or cerebrovascular diseases and combined with chemotherapy, leukocyte abnormality and hypoalbuminemia as a cause of fever are more likely to happen during radiotherapy. keywords: fever; patients cache: cord-287373-7xjn05k8.txt plain text: cord-287373-7xjn05k8.txt item: #1375 of 2876 id: cord-287376-wxldnlih author: Krüger, Colin M. title: Can surgery follow the dictates of the pandemic “keep your distance”? Requirements with COVID-19 for hygiene, resources and the team date: 2020-08-03 words: 3982 flesch: 41 summary: Requirements with COVID-19 for hygiene, resources and the team date: 2020-08-03 journal: GMS Hyg Infect Control DOI: 10.3205/dgkh000354 sha: doc_id: 287376 cord_uid: wxldnlih Since the beginning of the pandemic, there have been restrictions in the daily care of surgical patients – both elective and emergency. Surgical patient care with reduced intensive care and inpatient bed capacity 4. keywords: aerosols; air; care; covid-19; operating; pandemic; patients; room; staff; surgery; team; ventilation cache: cord-287376-wxldnlih.txt plain text: cord-287376-wxldnlih.txt item: #1376 of 2876 id: cord-287468-e5h4tmy6 author: Lopez, Alexandre title: Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results date: 2020-08-08 words: 1990 flesch: 47 summary: The Surviving Sepsis Campaign guidelines on the management of Covid-19 patients concluded there was insufficient evidence to recommend the use of antiviral drugs and hydroxychloroquine in ICU patients [7] . The primary objective of our study was to assess the effects of hydroxychloroquine according to its plasma concentration in ICU patients. keywords: covid-19; hydroxychloroquine; icu; patients; plasma; target cache: cord-287468-e5h4tmy6.txt plain text: cord-287468-e5h4tmy6.txt item: #1377 of 2876 id: cord-287497-93oiiqqi author: Tagliamento, Marco title: Italian survey on managing immune checkpoint inhibitors in oncology during COVID‐19 outbreak date: 2020-06-14 words: 3231 flesch: 40 summary: Immunotherapy blockade on severity of COVID-19 in patients with lung cancers Outcome of cancer patients infected with COVID-19, including toxicity of cancer treatments Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study. Cancer patients have been reported to experience a more severe COVID‐19 syndrome; moreover, there are concerns of an interference between immune checkpoint inhibitors (ICIs) and SARS‐CoV‐2 pathogenesis. keywords: cancer; cov-2; covid-19; icis; patients; respondents; sars cache: cord-287497-93oiiqqi.txt plain text: cord-287497-93oiiqqi.txt item: #1378 of 2876 id: cord-287505-ihqzpdar author: Narain, Sonali title: Comparative Survival Analysis of Immunomodulatory Therapy for COVID-19 'Cytokine Storm' date: 2020-10-17 words: 3654 flesch: 37 summary: COVID-19 patients hospitalized between March 1, 2020 and April 24, 2020 were included. In the timeframe of this analysis, hydroxychloroquine, azithromycin, colchicine and vitamin C, either alone or in combination, were administered to COVID-19 patients as part of institutional protocols (Supplemental e- keywords: anakinra; corticosteroids; covid-19; disease; groups; mortality; patients; tocilizumab; treatment cache: cord-287505-ihqzpdar.txt plain text: cord-287505-ihqzpdar.txt item: #1379 of 2876 id: cord-287508-133inel2 author: Vasudevan, Rajiv S. title: Persistent Value of the Stethoscope in the Age of COVID-19 date: 2020-06-19 words: 3740 flesch: 29 summary: Stethoscopes are clinically valuable and integral to the doctor-patient connection; • Technological advancement will augment the utility of the stethoscope; • The stethoscope has high utility for assessment of COVID-19 patients; • Pathogen contamination in light of COVID-19 is a concern for the stethoscope; • Innovations in stethoscope hygiene will allow safe auscultation. Hand contamination, which has a clear connection to healthcare associated infections, is also an independent predictor of stethoscope contamination 26 . keywords: care; contamination; covid-19; healthcare; heart; hygiene; infection; patients; stethoscope; study cache: cord-287508-133inel2.txt plain text: cord-287508-133inel2.txt item: #1380 of 2876 id: cord-287515-oe7adj91 author: Rello, Jordi title: Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China date: 2020-03-03 words: 1385 flesch: 38 summary: However, as many patients can remain asymptomatic or with very low symptomatology and because criteria of hospital admission were not standardised, the proportion of patients requiring supportive techniques for hypoxemia is probably lower. Our colleagues in Wuhan, who placed their lives at risk by treating patients with COVID-19, recently reported their experience in a scenario of crisis management with limited resources [1] . keywords: coronavirus; covid-19; influenza; patients; pneumonia cache: cord-287515-oe7adj91.txt plain text: cord-287515-oe7adj91.txt item: #1381 of 2876 id: cord-287520-51kmd2ds author: Carneiro, Arie title: Impact of the COVID-19 Pandemic on the Urologist’s clinical practice in Brazil: a management guideline proposal for low- and middle-income countries during the crisis period date: 2020-05-20 words: 4546 flesch: 42 summary: After the procedure, COVID-19 positive patients should be admitted to the designated areas for suspected and / or confirmed patients with COVID-19, if the institution in question provides such area. While efforts should be directed to the care of COVID-19 patients, other conditions (especially urgencies and oncological cases) must continue to be assisted. keywords: bladder; cancer; cases; chemotherapy; covid-19; pandemic; patients; prostate; risk; treatment; use cache: cord-287520-51kmd2ds.txt plain text: cord-287520-51kmd2ds.txt item: #1382 of 2876 id: cord-287538-qbf5lv7d author: Nucera, Eleonora title: Latex Allergy: Current Status and Future Perspectives date: 2020-09-28 words: 6693 flesch: 35 summary: Guidance for Industry and Food and Drug Administration Staff Process for Making Available Guidance Documents Related to Coronavirus Disease Primary prevention of natural rubber latex allergy in the German health care system through education and intervention Efficacy of latex avoidance for primary prevention of latex sensitization in children with spina bifida Reduction of latex sensitization in spina bifida patients by a primary prophylaxis programme (five years experience) Safety of a powder-free latex allergy protocol in the operating theatre: a prospective, observational cohort study American Society of Anesthesiologists Committee on Occupational Health of Operating Room Personnel Latex allergy in housekeeping personnel Personal exposure to inhalable dust and the specific latex aero-allergen, Hev b6.02, in latex glove manufacturing in Thailand Use of protective gloves by hairdressers: a review of efficacy and potential adverse effects Occupational management of type I latex allergy Bensefa-Colas L. Accelerator-free gloves as alternatives in cases of glove allergy in healthcare workers Secondary prevention of latex allergy in children: analysis of results Outcome of a latex avoidance program in a high-risk population for latex allergy -a five-year follow-up study Prevention of latex allergy among health care workers and in the general population: latex protein content in devices commonly used in hospitals and general practice Emergency treatment of anaphylactic reactions. The following eligibility criteria were used for article inclusion: population: patients with latex allergy and/or at risk for anaphylaxis; intervention: any approaches or protocols that incorporated a strategy for latex allergy and anaphylaxis management; comparator: any studies irrespective of whether there was a comparator included in the study design; outcomes: any related to prevalence, diagnostics, and treatments including primary prevention and immunotherapy; and study design: experimental studies and observational studies. keywords: allergy; gloves; hev; ige; immunotherapy; latex; nrla; patients; prevention; reactions; risk; rubber; sensitization; slit; use cache: cord-287538-qbf5lv7d.txt plain text: cord-287538-qbf5lv7d.txt item: #1383 of 2876 id: cord-287544-n32iscmr author: Solaimanzadeh, Isaac title: Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 date: 2020-05-12 words: 5449 flesch: 37 summary: CCB patients were also significantly less likely to undergo intubation and mechanical ventilation. CCB patients were also significantly less likely to undergo intubation and mechanical ventilation. keywords: amlodipine; ccb; covid-19; disease; group; hypertension; nifedipine; patients; treatment cache: cord-287544-n32iscmr.txt plain text: cord-287544-n32iscmr.txt item: #1384 of 2876 id: cord-287558-yc8aw2pg author: Duffy, Eamon Y. title: Primary and Secondary Prevention of Cardiovascular Disease in the Era of the Coronavirus Pandemic date: 2020-04-20 words: 709 flesch: 27 summary: Given their higher risk of complications, secondary prevention cardiovascular patients are at the center of social distancing measures, and their cardiologists need to ensure effective communication channels. Telemedicine and remote monitoring will make it easier to frequently reach patients to optimize risk factor control, titrate medications, assess diets and physical activity levels, and integrate reminders to meet daily goals, among other capabilities. keywords: health; patients; prevention cache: cord-287558-yc8aw2pg.txt plain text: cord-287558-yc8aw2pg.txt item: #1385 of 2876 id: cord-287648-nhsn4cru author: Cameli, Matteo title: Usefulness of echocardiography to detect cardiac involvement in COVID‐19 patients date: 2020-07-12 words: 3047 flesch: 21 summary: The left atrium and the right ventricle: two supporting chambers to the failing left ventricle Standardization of left atrial, right ventricular, and right atrial deformation imaging using two-dimensional speckle tracking echocardiography: a consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging ACUTE HF score, a multiparametric prognostic tool for acute heart failure: a real-life study Prognostic Value of Right Ventricular Longitudinal Strain in Patients with COVID-19 Echocardiography to guide fluid therapy in critically ill patients: check the heart and take a quick look at the lungs Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected Serial evaluation of the SOFA score to predict outcome in critically ill patients Prognostic impact of left ventricular diastolic function in patients with septic shock Early diastolic dysfunction is associated with intensive care unit mortality in cancer patients presenting with septic shock Outcome prediction in sepsis: speckle tracking echocardiography based assessment of myocardial function Left ventricular global longitudinal strain is independently associated with mortality in septic shock patients Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP) vs low PEEP on mortality in patients with acute respiratory distress syndrome: a randomized clinical trial Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: Interim guidance. Accordingly, current reports suggest that the majority of COVID-19 patients with myocardial injury without evidence of epicardial coronary artery thrombosis, show imaging data supporting the diagnosis of acute myocarditis 21, 22 ; also, cases of fulminant myocarditis and fatal arrhythmias have been described. keywords: acute; coronavirus; covid-19; disease; echocardiography; injury; myocarditis; patients; syndrome cache: cord-287648-nhsn4cru.txt plain text: cord-287648-nhsn4cru.txt item: #1386 of 2876 id: cord-287732-abzpfdcu author: Martindale, Robert title: Nutrition Therapy in Critically Ill Patients with Coronavirus Disease (COVID‐19) date: 2020-05-27 words: 6234 flesch: 37 summary: Unless vasopressor dose is escalating and/or enteral feeding intolerance ensues (e.g. ileus, abdominal distention, vomiting), circulatory shock associated with SARS-CoV-2 should not be seen as a contraindication to trophic EN. 5 Early EN may not be preferred in a subset of COVID-19 patients with GI symptoms. Continuous postive pressure ventilation through helmet has been used exensively in Italy for COVID-19 patients, and nutition maybe provided more effectively and safely than mask NIPPV, but data are needed. keywords: article; care; copyright; covid-19; enteral; feeding; icu; nutrition; patients; recommendation; rights; risk; therapy cache: cord-287732-abzpfdcu.txt plain text: cord-287732-abzpfdcu.txt item: #1387 of 2876 id: cord-287742-y1j9x5ne author: Lee, Kai Wei title: Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis date: 2020-10-06 words: 6552 flesch: 38 summary: Ischemic stroke was the predominant stroke, and it was observed in 90.3% of stroke cases as compared to 9.7% patients presenting with hemorrhagic stroke. The following data were extracted from every study: the last name of the first author, year of publication, country, severity status, study design, patient characteristics (ethnicity composition, gender, and mean age), comorbidities (diabetes, hyperlipidemia, hypertension, ischemic heart disease, heart failure, previous stroke, chronic kidney disease/end-stage renal disease, number of stroke patients per overall participants, any information relevant to strokes such as the location of stroke [arterial or venous]), types of stroke (ischemic or haemorrhagic), classification of stroke, mortality rate, and blood parameters. keywords: analysis; coronavirus; covid-19; data; disease; infection; ischemic; meta; patients; review; risk; stroke; studies cache: cord-287742-y1j9x5ne.txt plain text: cord-287742-y1j9x5ne.txt item: #1388 of 2876 id: cord-287758-da11ypiy author: Mônica Vitalino de Almeida, Sinara title: COVID-19 therapy: what weapons do we bring into battle? date: 2020-09-10 words: 17493 flesch: 35 summary: More preclinical and clinical studies are required to prove whether dasatinib is really promising for COVID-19 patient treatment. SBV is also combined with other antiviral drugs, such as ledipasvir, velpatasvir and voxilaprevir. keywords: action; activity; antiviral; binding; cells; clinical; coronavirus; cov-2; covid-19; disease; drug; entry; fig; host; human; infection; inhibitor; mechanism; new; novel; patients; potential; pro; protein; receptor; replication; results; rna; sars; studies; study; syndrome; synthesis; targets; therapy; treatment cache: cord-287758-da11ypiy.txt plain text: cord-287758-da11ypiy.txt item: #1389 of 2876 id: cord-287765-nsdequl9 author: Taiwo, Olutosin title: Smart healthcare support for remote patient monitoring during covid-19 quarantine date: 2020-09-15 words: 7112 flesch: 46 summary: Health monitoring systems have evolved to assist convenient healthy living, more accessible communication between healthcare givers and patients for close monitoring, measurement of vital health parameters, routine consultation and overall healthy living. There have been many published articles in the area of smart health care system, e-health and remote healthcare. keywords: application; context; doctor; health; healthcare; home; mobile; monitoring; patient; smart; system; user cache: cord-287765-nsdequl9.txt plain text: cord-287765-nsdequl9.txt item: #1390 of 2876 id: cord-287786-zfe0el8i author: Dudoignon, Emmanuel title: Activation of the Renin-angiotensin-aldosterone system is associated with Acute Kidney injury in COVID-19 date: 2020-06-18 words: 1014 flesch: 43 summary: Here, we describe the renal response of patients with COVID-19 patients admitted to an intensive care unit (ICU), with a particular focus on the activation of the renin-angiotensin-aldosterone system. Abstract The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. keywords: aki; covid-19; patients; raas cache: cord-287786-zfe0el8i.txt plain text: cord-287786-zfe0el8i.txt item: #1391 of 2876 id: cord-287874-wl0wlxh6 author: Wang, Ling title: Quadruple therapy for asymptomatic COVID-19 infection patients date: 2020-05-03 words: 5535 flesch: 42 summary: After large-scale interpersonal infection, asymptomatic patients appear. Whether asymptomatic patients are contagious or not and whether they need medication are the arguments among clinical experts. keywords: arbidol; asymptomatic; covid-19; drug; ifn; infection; lopinavir; patients; ritonavir; treatment; virus cache: cord-287874-wl0wlxh6.txt plain text: cord-287874-wl0wlxh6.txt item: #1392 of 2876 id: cord-287895-63wy5ztb author: Aponte Martín, Diego Mauricio title: Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era date: 2020-07-04 words: 932 flesch: 53 summary: Coronavirus disease (COVID-2019) Situation Report 51 COVID-19 and Italy: what next? SARS-CoV-2 viral load in upper respiratory specimens of infected patients Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review Risk of bacterial exposure to the endoscopist's face during endoscopy SARS-CoV-2 viral load in upper respiratory specimens of infected patients Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient Aerosol and surface stability of SARS-CoV2 as compared with SARS-CoV-1 AGA Institute rapid recommendations for gastrointestinal procedures during the COVID-19 pandemic key: cord-287895-63wy5ztb authors: Aponte Martín, Diego Mauricio; Corso, Claudia; Fuentes, Carlos; Aponte Aparicio, Maria Valentina; Sabbagh, Luis Carlos title: Use of a new face shield for patients of the endoscopy unit to avoid aerosol exchange in the COVID-19 era date: 2020-07-04 journal: VideoGIE DOI: 10.1016/j.vgie.2020.05.033 sha: doc_id: 287895 cord_uid: 63wy5ztb nan In December 2019, a new coronavirus called SARS-CoV-2 emerged from a zoonotic source in Wuhan, China. keywords: endoscopy; patient; shield cache: cord-287895-63wy5ztb.txt plain text: cord-287895-63wy5ztb.txt item: #1393 of 2876 id: cord-287901-56goaqir author: Maudgil, D.D. title: Cost effectiveness and the role of the National Institute of Health and Care Excellence (NICE) in interventional radiology date: 2020-10-17 words: 5024 flesch: 36 summary: The role of cost effectiveness studies in ensuring the best allocation of resources is discussed, and the role of National Institute of Health and Care Excellence (NICE) in determining this. key: cord-287901-56goaqir authors: Maudgil, D.D. title: Cost effectiveness and the role of the National Institute of Health and Care Excellence (NICE) in interventional radiology date: 2020-10-17 journal: Clin Radiol DOI: 10.1016/j.crad.2020.09.017 sha: doc_id: 287901 cord_uid: 56goaqir Healthcare expenditure is continually increasing and projected to accelerate in the future, with an increasing proportion being spent on interventional radiology. keywords: care; cost; effectiveness; endovascular; health; outcomes; patients; time; treatment; trials; versus cache: cord-287901-56goaqir.txt plain text: cord-287901-56goaqir.txt item: #1394 of 2876 id: cord-287953-prn8cnvo author: Shin, Nina title: Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea date: 2017-05-21 words: 6255 flesch: 33 summary: Details of patient room design, costs, and estimated number of infected patients are shown in Table 10 under the parametric settings of the number of beds ( BEDS = 40), the occupancy rate ( α = .85), the number of visitors per patient ( β = 3), and the infectivity rate ( λ low = .01, λ base = .05, λ high = .07). The Korean government has been trying to optimize patient room design by increasing numbers of multi-patient rooms rather than single-patient rooms, in order to minimize overall healthcare cost for its citizens, as announced at the 2015 Health Insurance Policy Review Committee Conference in Seoul. keywords: healthcare; hospital; infection; infectivity; korea; mers; model; number; outbreak; patient; rate; room; system cache: cord-287953-prn8cnvo.txt plain text: cord-287953-prn8cnvo.txt item: #1395 of 2876 id: cord-287957-diyz54qy author: Deriba, Berhanu Senbeta title: Patient Satisfaction and Associated Factors During COVID-19 Pandemic in North Shoa Health Care Facilities date: 2020-10-13 words: 4257 flesch: 40 summary: Overall, 44.6% of patients with chronic disease were satisfied with the service they received from health facilities. Therefore, this study aimed to assess patient satisfaction and associated factors during the COVID-19 pandemic among chronic patients who had follow-up at public health facilities in the North Shoa Zone, Oromia region, Ethiopia. keywords: covid-19; data; disease; facilities; health; healthcare; hospital; participants; patient; satisfaction; study cache: cord-287957-diyz54qy.txt plain text: cord-287957-diyz54qy.txt item: #1396 of 2876 id: cord-287991-10jz1dz2 author: Goshen-Lago, Tal title: The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study date: 2020-08-26 words: 4504 flesch: 41 summary: Cancer patients who were SARS-CoV-2 IgG+ (n = 4) were matched to cancer patients who were SARS-CoV-2 IgG-in terms of age, gender, cancer type, and treatment protocol (n = 4). key: cord-287991-10jz1dz2 authors: Goshen-Lago, Tal; Szwarcwort-Cohen, Moran; Benguigui, Madeleine; Almog, Ronit; Turgeman, Ilit; Zaltzman, Nelly; Halberthal, Michael; Shaked, Yuval; Ben-Aharon, Irit title: The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study date: 2020-08-26 journal: Cancers (Basel) DOI: 10.3390/cancers12092421 sha: doc_id: 287991 cord_uid: 10jz1dz2 SIMPLE SUMMARY: Despite lack of concrete evidence, cancer patients were considered at the onset of the COVID19 pandemic as high-risk population for COVID19 infection. keywords: cancer; cells; cov-2; covid19; healthcare; patients; sars; study; workers cache: cord-287991-10jz1dz2.txt plain text: cord-287991-10jz1dz2.txt item: #1397 of 2876 id: cord-288009-8i3gsq9p author: Javor, S. title: Why not consider an endothelin receptor antagonist against SARS‐CoV‐2? date: 2020-04-25 words: 672 flesch: 39 summary: In patients with HIV infection, PAH is a life-threatening complication [14] . New therapeutic opportunities for COVID-19 patients with Tocilizumab: Possible correlation of interleukin-6 receptor inhibitors with osteonecrosis of the jaws Evaluation of the effect of bosentan treatment on proinflammatory cytokine serum levels in patients affected by systemic sclerosis Pulmonary arterial hypertension related to HIV: is inflammation related to IL-6 the cornerstone? keywords: bosentan; infection; patients cache: cord-288009-8i3gsq9p.txt plain text: cord-288009-8i3gsq9p.txt item: #1398 of 2876 id: cord-288033-9xu1ujcq author: Zeng, Jie title: How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital date: 2020-03-11 words: 431 flesch: 49 summary: The door-to-balloon time in NSTMI patients is less strict than that in STEMI patients. The emergency call should instruct patients to choose the nearest center that can complete primary percutaneous coronary intervention (PCI) treatment. keywords: patients; pci cache: cord-288033-9xu1ujcq.txt plain text: cord-288033-9xu1ujcq.txt item: #1399 of 2876 id: cord-288040-uuqfvvmk author: Kapoor, Saloni title: Developing a pediatric ophthalmology telemedicine program in the COVID-19 crisis date: 2020-09-02 words: 3081 flesch: 43 summary: Flowcharts were devised to schedule and implement telemedicine visits. Flowcharts were devised to schedule and implement telemedicine visits. keywords: care; ophthalmology; patients; person; telemedicine; visit cache: cord-288040-uuqfvvmk.txt plain text: cord-288040-uuqfvvmk.txt item: #1400 of 2876 id: cord-288051-wp8v2mc5 author: Sánchez-González, Álvaro title: What Should Be Known by a Urologist About the Medical Management of COVID-19’s Patients? date: 2020-09-01 words: 3624 flesch: 45 summary: The infection and isolation of many physicians reduced its availability to struggle against COVID-19, so it became essential to recruit surgical staff to assist COVID-19 patients. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Pharmacologic treatments for coronavirus disease 2019 (COVID-19) a review COVID-19) outbreak: what the department of radiology should know Compassionate use of remdesivir for patients with severe Covid-19 Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Effective treatment of severe COVID-19 patients with tocilizumab Why tocilizumab could be an effective treatment for severe COVID -19 ? keywords: coronavirus; cov-2; covid-19; days; disease; fig; infection; management; patients; sars; treatment cache: cord-288051-wp8v2mc5.txt plain text: cord-288051-wp8v2mc5.txt item: #1401 of 2876 id: cord-288067-36amafub author: Ashraf, Mohammad Ali title: COVID-19 in Iran, a comprehensive investigation from exposure to treatment outcomes date: 2020-04-24 words: 4375 flesch: 53 summary: [6] [7] [8] [9] This study is one of the first reports of COVID-19 patients from Iran. We presented the first 100 cases of COVID-19 patients in Tehran. keywords: covid-19; discharge; disease; hospital; medrxiv; patients; preprint; review; score cache: cord-288067-36amafub.txt plain text: cord-288067-36amafub.txt item: #1402 of 2876 id: cord-288102-iom6lu7o author: Han, Jing title: Analysis of factors affecting the prognosis of COVID-19 patients and viral shedding duration date: 2020-06-25 words: 4293 flesch: 47 summary: Severe patients were treated with lopinavir or ritonavir. One of the limitations of this study is that we assessed patients for only a limited time when they were hospitalised; thus, a longer follow-up period might be needed to further assess the prognosis of and viral shedding in cured COVID-19 patients. keywords: covid-19; duration; patients; prognosis; shedding; study; time; treatment cache: cord-288102-iom6lu7o.txt plain text: cord-288102-iom6lu7o.txt item: #1403 of 2876 id: cord-288158-6gicgsj8 author: Mahammedi, Abdelkader title: Imaging of Neurologic Disease in Hospitalized Patients with COVID-19: An Italian Multicenter Retrospective Observational Study date: 2020-05-21 words: 1106 flesch: 38 summary: Currently, we have a poor mechanistic understanding of the neurologic symptoms in patients with COVID-19, whether these are arising from critical illness or from direct central nervous system invasion of severe acute respiratory syndrome coronavirus 2 (10). Of the 31 patients without known past medical history (age range, 16-62 years) (29%), Our study demonstrated that the neurologic imaging features of hospitalized patients with COVID-19 were variable, without a specific pattern but dominated by acute ischemic infarcts and intracranial hemorrhages. keywords: acute; covid-19; mri; patients cache: cord-288158-6gicgsj8.txt plain text: cord-288158-6gicgsj8.txt item: #1404 of 2876 id: cord-288181-9thl46oe author: Fekkar, Arnaud title: Fungal Infection during COVID-19: Does Aspergillus Mean Secondary Invasive Aspergillosis? date: 2020-09-15 words: 1542 flesch: 34 summary: Nor can the criteria presented by Schauwvlieghe and colleagues rule out invasive pulmonary aspergillosis in the presented cases (2) . A clinical algorithm to diagnose invasive pulmonary aspergillosis in critically ill patients keywords: aspergillosis; covid-19; patients cache: cord-288181-9thl46oe.txt plain text: cord-288181-9thl46oe.txt item: #1405 of 2876 id: cord-288197-drto66xt author: Chen, Huijun title: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records date: 2020-02-12 words: 3939 flesch: 51 summary: Considering that SARS-CoV-2 has up to 85% sequence similarity with SARS, [11] [12] [13] [14] although none of our patients developed severe pneumonia or died of COVID-19 infection, we should be alert to the possibility that the disease course and prognosis of COVID-19 pneumonia could follow the same trend as SARS in pregnant women. Answers to these questions are essential for formulating the principles of obstetric treatment for pregnant women with COVID-19 infection. keywords: clinical; covid-19; infection; patients; pneumonia; samples; sars; women cache: cord-288197-drto66xt.txt plain text: cord-288197-drto66xt.txt item: #1406 of 2876 id: cord-288222-8fqfbys2 author: Hardy, Michaël title: Prothrombotic Disturbances of Hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational Study date: 2020-10-24 words: 1198 flesch: 37 summary: Published data so far are consistent with defective fibrinolysis in COVID-19 patients (which is not unique to this infectious condition), using viscoelastometric assays modified with tPA addition (5, 6, 9) . In light of these results and of the current knowledge on hemostasis disturbances of COVID-19 patients, we suggest that a close monitoring of a sensible set hemostatic parameters would be useful to assess individual thrombotic risk. keywords: covid-19; icu; levels; patients cache: cord-288222-8fqfbys2.txt plain text: cord-288222-8fqfbys2.txt item: #1407 of 2876 id: cord-288255-p8uzrsbd author: Goossens, Gijs H. title: Obesity and COVID-19: A Perspective from the European Association for the Study of Obesity on Immunological Perturbations, Therapeutic Challenges, and Opportunities in Obesity date: 2020-08-13 words: 7056 flesch: 32 summary: COVID-19: consider cytokine storm syndromes and immunosuppression Validation of predictors of disease severity and outcomes in COVID-19 patients: a descriptive and retrospective study APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort Apolipoprotein E -a multifunctional protein with implications in various pathologies as a result of its structural features Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders Angiotensin II receptors and angiotensin II receptor antagonists Physiology and pathophysiology of the adipose tissue renin-angiotensin system The renin-angiotensin system in the pathophysiology of type 2 diabetes Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2 Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor A pneumonia outbreak associated with a new coronavirus of probable bat origin Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. In COVID-19 patients, elevated plasma concentrations of both proinflammatory Th1 and anti-inflammatory Th2 cytokines were found [3] . keywords: adipose; angiotensin; coronavirus; cov-2; covid-19; disease; immune; infection; obesity; patients; people; risk; sars; tissue; treatment cache: cord-288255-p8uzrsbd.txt plain text: cord-288255-p8uzrsbd.txt item: #1408 of 2876 id: cord-288271-p074ffpt author: Mathies, D. title: A Case of SARS‐CoV‐2‐pneumonia with successful antiviral therapy in a 77‐year‐old male with heart transplant date: 2020-04-21 words: 2485 flesch: 46 summary: key: cord-288271-p074ffpt authors: Mathies, D.; Rauschning, D.; Wagner, U.; Mueller, F.; Maibaum, M.; Binnemann, C.; Waldeck, S.; Thinnes, K.; Braun, M.; Schmidbauer, W.; Hagen, RM.; Bickel, C. title: A Case of SARS‐CoV‐2‐pneumonia with successful antiviral therapy in a 77‐year‐old male with heart transplant date: 2020-04-21 journal: Am J Transplant DOI: 10.1111/ajt.15932 sha: doc_id: 288271 cord_uid: p074ffpt The SARS‐CoV‐2‐infection can be seen as a single disease but also affects patients with relevant comorbidities who may have an increased risk of a severe course of infection. Only a fistful of cases of a SARS-CoV 2-Infection in patients who received a solid organ transplant has been published so far [9, 10] . keywords: days; medication; patient; sars; therapy; transplant cache: cord-288271-p074ffpt.txt plain text: cord-288271-p074ffpt.txt item: #1409 of 2876 id: cord-288371-uyj4iske author: Arrieta, Oscar title: Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: The THOCOoP cooperative group date: 2020-06-20 words: 6676 flesch: 36 summary: patients with advanced non-small-cell lung cancer and poor performance status Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial) Telemedicine for cancer patients during COVID-19 pandemic: between threats and opportunities Hyperprogressive Disease in Patients With Advanced Non-Small Cell Lung Cancer Treated With PD-1/PD-L1 Inhibitors or With Single-Agent Chemotherapy Immune-related adverse events with immune checkpoint inhibitors in thoracic malignancies: focusing on non-small cell lung cancer patients Characteristics and outcomes of small cell lung cancer patients diagnosed during two lung cancer computed tomographic screening programs in heavy smokers American College of Chest Physicians evidence-based clinical practice guidelines A Meta-Analysis of Thoracic Radiotherapy for Small-Cell Lung Cancer Systematic review evaluating the timing of thoracic radiation therapy in combined modality therapy for limited-stage small-cell lung cancer Time between the first day of chemotherapy and the last day of chest radiation is the most important predictor of survival in limited-disease small-cell lung cancer Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission Carboplatin-or cisplatin-based chemotherapy in first-line treatment of small-cell lung cancer: the COCIS meta-analysis of individual patient data First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer Role of thoracic consolidation radiation in extensive stage small cell lung cancer: Relevant information has emerged regarding the higher risk of poor outcomes in lung cancer patients. keywords: cancer; cell; chemotherapy; clinical; covid-19; disease; lung; mesothelioma; non; pandemic; patients; phase; recommendation; treatment cache: cord-288371-uyj4iske.txt plain text: cord-288371-uyj4iske.txt item: #1410 of 2876 id: cord-288509-l6yn2er7 author: Kalu, Peter title: The rules for online clinical engagement in the COVID era date: 2020-08-22 words: 3026 flesch: 44 summary: Notably, the urgent need for remote consultations has brought strategies such as video consultation to the forefront of national digital health initiatives. Video consultations are increasingly common in primary care with the latest NHS long-term plan mandating access to online primary care services by 2023/24. keywords: care; consultations; consulting; online; patient; remote; video cache: cord-288509-l6yn2er7.txt plain text: cord-288509-l6yn2er7.txt item: #1411 of 2876 id: cord-288552-7lp07v5i author: Vahedi, Ensieh title: The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study date: 2020-06-19 words: 4922 flesch: 34 summary: While corticosteroids were not routinely recommended for treatment of COVID-19 patients, a retrospective cohort study of COVID-19 in Wuhan, China reported the benefits of methylprednisolone by decreasing the risk of death due to COVID-19 in patients who developed ARDS On the use of corticosteroids for 2019-nCoV pneumonia Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis Mesenchymal stem cell therapy for COVID-19: present or future A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 Lopinavir-ritonavir in severe COVID-19 Covid-19-the search for effective therapy Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza a virus Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection Inpatient use of Mobile continuous telemetry for COVID-19 patients treated with Hydroxychloroquine and azithromycin Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study A major outbreak of severe acute respiratory syndrome in Hong Kong Erythrocyte sedimentation rate and Creactive protein: how best to use them in clinical practice Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment Ni A-p. expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome Adaptive immune cells temper initial innate responses Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Acknowledgements keywords: combination; covid-19; disease; group; patients; regimen; study; treatment; use cache: cord-288552-7lp07v5i.txt plain text: cord-288552-7lp07v5i.txt item: #1412 of 2876 id: cord-288558-rthnj6wd author: Cheng, V. C. C. title: Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome date: 2004-02-15 words: 3807 flesch: 42 summary: Summary table of SARS cases by country A novel coronavirus associated with severe acute respiratory syndrome Identification of a novel coronavirus in patients with severe acute respiratory syndrome Coronavirus as a possible cause of severe acute respiratory syndrome Koch's postulates fulfilled for SARS virus Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Detection of SARS coronavirus (SCoV) by RT-PCR, culture, and serology in patients with acute respiratory syndrome (SARS) The lung and the gastrointestinal tract may react differently to SARS coronavirus infection. keywords: coronavirus; days; diarrhea; onset; patients; sars; severe; symptoms; syndrome cache: cord-288558-rthnj6wd.txt plain text: cord-288558-rthnj6wd.txt item: #1413 of 2876 id: cord-288575-srpc68t8 author: Yamakage, Michiaki title: Anesthesia in the times of COVID-19 date: 2020-05-25 words: 1317 flesch: 27 summary: Anesthesia Pediatric laryngoscopy and bronchoscopy during the COVID-19 pandemic: a four-center collaborative protocol to improve safety with perioperative management strategies and creation of a surgical tent with disposable drapes A process for daily checks when using anaesthetic machines to ventilate the lungs of COVID-19 patients: the 'domino switch' technique Management of CO 2 absorbent while using the anesthetic machine as a mechanical ventilator as a mechanical ventilator on patients with COVID Is regional anesthesia safe enough in suspected of confirmed COVID-19 patients? Much of the initial literature on the management of COVID-19 patients comes from Wuhan, China, with articles subsequently published worldwide [5] [6] [7] [8] . keywords: anesthesia; coronavirus; covid-19; patients cache: cord-288575-srpc68t8.txt plain text: cord-288575-srpc68t8.txt item: #1414 of 2876 id: cord-288580-onzzpkye author: HALAÇLI, Burçin title: Critically ill COVID-19 patient date: 2020-04-21 words: 3808 flesch: 41 summary: For this purpose, elective in-patient admissions and surgeries should be delayed and available wards could be adapted for stepping down other ICU patients in order to evacuate ICUs. In this review, we aimed to emphasize the crucial points regarding intensive care management of COVID-19 patients, which we have written not only for intensivists but also for all healthcare professionals. keywords: care; coronavirus; covid-19; icu; intubation; patients; pneumonia; pressure; risk; ventilation cache: cord-288580-onzzpkye.txt plain text: cord-288580-onzzpkye.txt item: #1415 of 2876 id: cord-288606-h8pmqwmk author: Alhmoud, Eman title: Anticoagulation clinic drive-up service during COVID-19 pandemic in Qatar date: 2020-07-03 words: 1944 flesch: 39 summary: This service can reduce the risk of exposure of anticoagulation patients to COVID-19 by reducing the contact time with the different personnel at the hospital and by maintaining those patients at a safe distance from others Coronavirus Disease 2019 (COVID-19) is a pandemic that has been spreading to more than 200 countries worldwide. This service is one of the efforts of healthcare providers to reduce the risk of exposure of anticoagulation patients to COVID-19 by reducing the contact time with the different personnel at the hospital and by maintaining those patients at a safe distance from others. keywords: anticoagulation; clinic; patients; service; testing cache: cord-288606-h8pmqwmk.txt plain text: cord-288606-h8pmqwmk.txt item: #1416 of 2876 id: cord-288697-9dywuhkc author: Noone, Rachel title: LETTER TO THE EDITOR: NEW ONSET PSYCHOSIS AND MANIA FOLLOWING COVID-19 INFECTION date: 2020-08-08 words: 1312 flesch: 43 summary: Relationships between neural activation during a reward task and peripheral cytokine levels in youth with diverse psychiatric symptoms A pilot resting-state functional connectivity study of the kynurenine pathway in adolescents with depression and healthy controls The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic Manipulation of brain kynurenines: Glial targets, neuronal effects, and clinical opportunities Infection and inflammation in schizophrenia and bipolar disorder Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? At discharge, Patient A continued to show residual increased speech latency and psychomotor retardation. keywords: patient cache: cord-288697-9dywuhkc.txt plain text: cord-288697-9dywuhkc.txt item: #1417 of 2876 id: cord-288790-5uzgenty author: Govil, Gaurav title: Rehabilitation of Arthroplasty Patient During Covid-19 date: 2020-05-24 words: 321 flesch: 39 summary: A guide Orthopaedics in times of COVID 19 The role of physical therapists in the medical response team following a natural disaster: Our experience in Nepal Total knee arthroplasty rehabilitation protocol: What makes the difference? Lack Management of orthopaedic patients during COVID-19 pandemic in India: keywords: rehabilitation cache: cord-288790-5uzgenty.txt plain text: cord-288790-5uzgenty.txt item: #1418 of 2876 id: cord-288810-ab7k70c4 author: Zheng, Yingyan title: Development and Validation of a Prognostic Nomogram Based on Clinical and CT Features for Adverse Outcome Prediction in Patients with COVID-19 date: 2020-06-24 words: 3376 flesch: 39 summary: Notably, patients who experienced adverse clinical outcomes tended to demonstrate crazy-paving sign to a more abnormal extent on admission. Clinical characteristics of coronavirus disease 2019 in China Fleischner Society: glossary of terms for thoracic imaging Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 patients Epidemiology, genetic recombination, and pathogenesis of coronaviruses Origin and evolution of pathogenic coronaviruses Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Prognostic Nomogram for Adverse Outcome Prediction in Patients with COVID-19 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Sexual dimorphism in innate immunity Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Radiology perspective of coronavirus disease 2019 (COVID-19): lessons from severe acute respiratory syndrome and Middle East respiratory syndrome Prognostic significance of crazy paving ground grass opacities in non-HIV pneumocystis Jirovecii pneumonia: an observational cohort study keywords: cohort; coronavirus; covid-19; features; patients; prognostic; validation cache: cord-288810-ab7k70c4.txt plain text: cord-288810-ab7k70c4.txt item: #1419 of 2876 id: cord-289006-7dv1zsp9 author: Tan, Kimberly-Anne title: Addressing Coronavirus Disease 2019 in Spine Surgery: A Rapid National Consensus Using the Delphi Method via Teleconference date: 2020-05-14 words: 4531 flesch: 36 summary: The efficacy of these swift draconian measures, guided in-part by bitter lessons learned during the 2003 SARS pandemic [3] , was reflected by the low rate of new COVID-19 cases, garnering Singapore international praise for what appeared an early flattening of the curve [4, 5] . However, given the inherently wide spectrum and time-sensitive nature in which spine pathologies tend to present, triaging spine cases while balancing the duties of a spine surgeon and managing COVID-19 cases has proven challenging (as discussed in a subsequent section). keywords: cases; covid-19; pandemic; patients; services; singapore; spinal; spine; surgeons; surgery; testing cache: cord-289006-7dv1zsp9.txt plain text: cord-289006-7dv1zsp9.txt item: #1420 of 2876 id: cord-289008-c4cu3vrp author: Wallis, Christopher J.D. title: Risks from Deferring Treatment for Genitourinary Cancers: A Collaborative Review to Aid Triage and Management During the COVID-19 Pandemic date: 2020-05-03 words: 9378 flesch: 41 summary: The timing of radical cystectomy for bacillus Calmette-Guerin failure: comparison of outcomes and risk factors for prognosis Transurethral resection of bladder tumour: the neglected procedure in the technology race in bladder cancer A systematic review and meta-analysis of delay in radical cystectomy and the effect on survival in bladder cancer patients Longer wait times increase overall mortality in patients with bladder cancer Delaying radical cystectomy after neoadjuvant chemotherapy for muscle-invasive bladder cancer is associated with adverse survival outcomes Delays in radical cystectomy for muscle-invasive bladder cancer A delay 8 weeks to neoadjuvant chemotherapy before radical cystectomy increases the risk of upstaging Assessing the impact of time to cystectomy for variant histology of urothelial bladder cancer Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China Effectiveness of adjuvant chemotherapy for locally advanced bladder cancer Radiotherapy with or without chemotherapy in muscleinvasive bladder cancer Efficacy and safety of dose-dense chemotherapy in urothelial carcinoma Clinical outcome after progressing to frontline and second-line Anti-PD-1/PD-L1 in advanced urothelial cancer Adverse event profile for immunotherapy agents compared with chemotherapy in solid organ tumors: a systematic review and meta-analysis of randomized clinical trials Advice regarding systemic therapy in patients with urological cancers during the COVID-19 pandemic Cancer statistics Cancer statistics, 2020 Co-morbidities in a retrospective cohort of prostate cancer patients Feasibility study: watchful waiting for localized low to intermediate grade prostate carcinoma with selective delayed intervention based on prostate specific antigen, histological and/or clinical progression 10-Year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer Ten-year mortality, disease progression, and treatmentrelated side effects in men with localised prostate cancer from the ProtecT randomised controlled trial according to treatment received Active surveillance for intermediate risk prostate cancer: survival outcomes in the Sunnybrook experience Impact of the length of time between diagnosis and surgical removal of urologic neoplasms on survival Timing of curative treatment for prostate cancer: a systematic review Evaluating the impact of length of time from diagnosis to surgery in patients with unfavourable intermediate-risk to very-high-risk clinically localised prostate cancer While acknowledging the significant psychologic burden associated with a cancer diagnosis, likely magnified by delays in treatment, physicians who treat cancer patients must be good stewards of limited health care resources, particularly in the time of a pandemic. keywords: cancer; carcinoma; covid-19; delays; disease; metastatic; outcomes; patients; risk; studies; survival; therapy; treatment cache: cord-289008-c4cu3vrp.txt plain text: cord-289008-c4cu3vrp.txt item: #1421 of 2876 id: cord-289046-frhpt8n9 author: Fix, Oren K. title: Telemedicine and Telehepatology During the COVID‐19 Pandemic date: 2020-05-21 words: 1475 flesch: 43 summary: As a result, there has been a sudden and substantial increase in telemedicine visits for urgent and nonurgent ambulatory care both related and unrelated to COVID-19, and patient satisfaction for telemedicine care has been consistently high. The Centers for Medicare and Medicaid Services (CMS) places substantial barriers to the use of telemedicine by restricting it to patients who reside in rural areas and who must travel to a local medical facility (e.g., doctor's office, hospital, dialysis facility, or skilled nursing facility) to receive telemedicine services from a doctor in a remote location. keywords: care; covid-19; patients; telemedicine cache: cord-289046-frhpt8n9.txt plain text: cord-289046-frhpt8n9.txt item: #1422 of 2876 id: cord-289054-fh95b5n4 author: Au Yong, Phui S. title: Reducing droplet spread during airway manipulation: lessons from the COVID-19 pandemic in Singapore date: 2020-04-15 words: 1183 flesch: 46 summary: We identified a potential shortcoming in that none of these measures reduced the production and spread of respiratory secretions, which contain the bulk of the viral burden. In summary, these low-cost, accessible, and disposable methods can reduce contamination by respiratory secretions at the source. keywords: intubation; mask; patient; tent cache: cord-289054-fh95b5n4.txt plain text: cord-289054-fh95b5n4.txt item: #1423 of 2876 id: cord-289064-435bp4rt author: Muniangi-Muhitu, Hermine title: Covid-19 and Diabetes: A Complex Bidirectional Relationship date: 2020-10-08 words: 5755 flesch: 32 summary: We consider roles for the immune system, the observed phenomenon of microangiopathy in severe Covid-19 infection and the potential for direct viral toxicity on metabolically-relevant tissues including pancreatic beta cells and targets of insulin action. The most common comorbidities with Covid-19 infection are metabolic diseases including diabetes, hypertension, obesity and cardiovascular disease (9, 10, 13) . keywords: ace2; cells; covid-19; diabetes; disease; immune; infection; insulin; patients; receptor; risk; sars; type cache: cord-289064-435bp4rt.txt plain text: cord-289064-435bp4rt.txt item: #1424 of 2876 id: cord-289088-7uoia564 author: Ding, Qiang title: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China date: 2020-03-30 words: 1520 flesch: 43 summary: We found that only one of five patients had T A B L E 1 Clinical characteristics of patients infected with COVID-19 and influenza virus when admitted to hospital Signs and symptoms patients) had diarrhea during the treatment period. key: cord-289088-7uoia564 authors: Ding, Qiang; Lu, Panpan; Fan, Yuhui; Xia, Yujia; Liu, Mei title: The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China date: 2020-03-30 journal: J Med Virol DOI: 10.1002/jmv.25781 sha: doc_id: 289088 cord_uid: 7uoia564 The outbreak of 2019 novel coronavirus (COVID‐19) infection emerged in Wuhan, China, in December 2019. keywords: clinical; influenza; patients; virus cache: cord-289088-7uoia564.txt plain text: cord-289088-7uoia564.txt item: #1425 of 2876 id: cord-289114-ifnk41oq author: Singh, Angaraj title: Effect of pre‐existing diseases on COVID‐19 infection and role of new sensors and biomaterials for its detection and treatment date: 2020-10-28 words: 6903 flesch: 48 summary: All rights reserved Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study Use of convalescent plasma therapy in SARS patients in Hong Kong Clinical Trials. All rights reserved A novel human coronavirus: Middle East respiratory syndrome human coronavirus Loneliness as a public health issue: the impact of loneliness on health care utilization among older adults Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor The mechanism of resistance to favipiravir in influenza The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response Isolation and characterization of viruses related to the SARS coronavirus from animals in Southern China Myocardial injury may be key in predicting COVID-19 fatalities The origin, transmission and clinical therapies on coronavirus disease-2019 (COVID-19) outbreak -an update on the Status Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2 cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan Accepted Article keywords: article; copyright; coronavirus; cov-2; covid-19; detection; et al; infection; novel; patients; pcr; plasma; rights; sars; treatment cache: cord-289114-ifnk41oq.txt plain text: cord-289114-ifnk41oq.txt item: #1426 of 2876 id: cord-289115-bntcn0m6 author: Thangaraju, Pugazhenthan title: Role of Dupilumab in Approved Indications of COVID-19 Patient: an Efficacy-Based Nonsystematic Critical Analysis date: 2020-09-10 words: 2138 flesch: 44 summary: There are isolated case reports and series that document a milder course of COVID-19 infection in patients who have already been on dupilumab therapy for treatment of conditions such as atopic dermatitis and chronic rhino-sinusitis with nasal polyp. The International League of Dermatological Society (ILDS) guidance in contrast asserts that current evidence does not justify the discontinuation of dupilumab therapy for AD in healthy subjects [8] . keywords: covid-19; dupilumab; infection; patients; therapy cache: cord-289115-bntcn0m6.txt plain text: cord-289115-bntcn0m6.txt item: #1427 of 2876 id: cord-289169-3u7qgxud author: Fang, Xiaowei title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 date: 2020-04-11 words: 496 flesch: 38 summary: More severe patients were treated with corticosteroids, leading to inconsistent baseline data (i.e., age, comorbidities and laboratory findings) between patients receiving corticosteroids and those who did not. key: cord-289169-3u7qgxud authors: Fang, Xiaowei; Mei, Qing; Yang, Tianjun; Li, Lei; Wang, Yinzhong; Tong, Fei; Geng, Shike; Pan, Aijun title: Low-dose corticosteroid therapy does not delay viral clearance in patients with COVID-1 date: 2020-04-11 journal: J Infect DOI: 10.1016/j.jinf.2020.03.039 sha: doc_id: 289169 cord_uid: 3u7qgxud nan drugs and symptomatic therapies. keywords: data; patients cache: cord-289169-3u7qgxud.txt plain text: cord-289169-3u7qgxud.txt item: #1428 of 2876 id: cord-289179-3zfur0zh author: Mascarin, Maurizio title: How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients date: 2020-04-11 words: 543 flesch: 19 summary: How to reorganize the access of children in a radiotherapy department in the era of COVID19, in order to protect themselves and elderly patients According to Liang 1 , as of Jan 31, 2020, based on a cohort of patients in China, 1% of coronavirus disease (COVID-19) cases had a history of cancer. Although direct evidence is lacking to support changing or withholding anticancer therapy in cancer patients 2,3 , the report showed that they had poorer outcomes from COVID-19, especially older patients 1 Our Cancer Institute, located in North-Eastern Italy, treats 120 outpatients daily with radiotherapy, coming from different Italian regions: 52% are over 65 years of age (several with co-morbidities) and 7% are younger than 10 years. keywords: patients; radiotherapy cache: cord-289179-3zfur0zh.txt plain text: cord-289179-3zfur0zh.txt item: #1429 of 2876 id: cord-289219-qjxdggz3 author: Sebio-García, Raquel title: Pulmonary Rehabilitation: Time for an Upgrade date: 2020-08-25 words: 1867 flesch: 25 summary: Since early 1980s, pulmonary rehabilitation has been acknowledged as a comprehensive intervention with hundreds of studies being performed over the past thirty years demonstrating its benefits on multiple outcomes; nevertheless, there are still multiple unresolved challenges, and new ones are currently emerging, with the COVID-19 outbreak now in the spotlight. In this editorial, these issues are summarized and discussed, while presenting some of the latest findings in research and clinical practice, with the ultimate goal of raising awareness of the future of pulmonary rehabilitation in the post COVID-19 era. keywords: covid-19; disease; patients; rehabilitation cache: cord-289219-qjxdggz3.txt plain text: cord-289219-qjxdggz3.txt item: #1430 of 2876 id: cord-289311-0wgafqdz author: Kim, Jee-Eun title: Neurological Complications during Treatment of Middle East Respiratory Syndrome date: 2017-06-30 words: 3560 flesch: 39 summary: Critical-illness polyneuropathy/myopathy appears frequently in ICU patients but was not thought JCN to be present in patient 1 because ophthalmoparesis and ptosis are very rare in critical-illness polyneuropathy/myopathy. However, we considered it unlikely that Wernicke's encephalopathy was present in patient 1 for several reasons: 1) he showed none of the typical changes associated with Wernicke's encephalopathy in brain MRI, which has particularly high sensitivity (97-100%) in patients without alcohol abuse, 17 2) the ptosis and complete ophthalmoplegia that were observed in this patient are rare in Wernicke's encephalopathy, 18 and 3) thiamine deficiency was not confirmed in laboratory tests and the patient did not have dietary deficiencies or alcoholism. keywords: cov; mers; patients; symptoms; syndrome; treatment; weakness cache: cord-289311-0wgafqdz.txt plain text: cord-289311-0wgafqdz.txt item: #1431 of 2876 id: cord-289322-5ciaonf0 author: Chen, X. title: Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study date: 2020-03-06 words: 3874 flesch: 52 summary: key: cord-289322-5ciaonf0 authors: Chen, X.; Zheng, F.; Qing, Y.; Ding, S.; Yang, D.; Lei, C.; Yin, Z.; Zhou, X.; Jiang, D.; Zuo, Q.; He, J.; Lv, J.; Chen, P.; Chen, Y.; Peng, H.; Li, H.; Xie, Y.; Liu, J.; Zhou, Z.; Luo, H. title: Epidemiological and clinical features of 291 cases with coronavirus disease 2019 in areas adjacent to Hubei, China: a double-center observational study date: 2020-03-06 journal: nan DOI: 10.1101/2020.03.03.20030353 sha: doc_id: 289322 cord_uid: 5ciaonf0 Abstract Background: The clinical outcomes of COVID-19 patients in Hubei and other areas are different. Interpretation: The epidemiological and clinical characteristics of COVID-19 patients in Hunan is different from patients in Wuhan. keywords: clinical; covid-19; group; patients; preprint; study; wuhan cache: cord-289322-5ciaonf0.txt plain text: cord-289322-5ciaonf0.txt item: #1432 of 2876 id: cord-289457-06gwrpu0 author: Berth, Sarah H. title: Secondary Causes of Myositis date: 2020-10-06 words: 3815 flesch: 25 summary: A randomized controlled phase II trial is underway examining tocilizumab treatment of myositis patients (ClinicalTrials.gov identifier: NCT02043548). A multicenter cooperative study Prostate cancer underlying acute, definitive dermatomyositis: successful treatment with radical perineal prostatectomy Cancerassociated myositis: clinical features and prognostic signs Sporadic inclusion body myositis: pilot study on the effects of a home exercise program on muscle function, histopathology and inflammatory reaction Improvement in aerobic capacity after an exercise program in sporadic inclusion body myositis Exercise in inflammatory myopathies, including inclusion body myositis Safety and efficacy of strength training in patients with sporadic inclusion body myositis Improvement in health and possible reduction in disease activity using endurance exercise in patients with established polymyositis and dermatomyositis: a multicenter randomized controlled trial with a 1-year open extension followup Benefits of intensive resistance training in patients with chronic polymyositis or dermatomyositis Community exercise is feasible for neuromuscular diseases and can improve aerobic capacity Rituximab in the treatment of inflammatory myopathies: a review Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series Longitudinal course of disease in a large cohort of myositis patients with autoantibodies recognizing the signal recognition particle Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: a randomized, placebophase trial Although this study did not meet its primary endpoint, 83% patients with refractory dermatomyositis or polymyositis met definition of improvement Abatacept as a successful therapy for myositis-a case-based review Abatacept for severe immune checkpoint inhibitor-associated myocarditis Abatacept in the treatment of adult dermatomyositis and polymyositis: a randomised, phase IIb treatment delayed-start trial JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis Tofacitinib citrate for refractory cutaneous dermatomyositis: an alternative treatment A case of refractory dermatomyositis responsive to tofacitinib. keywords: body; dermatomyositis; disease; inclusion; myositis; patients; polymyositis; study; treatment cache: cord-289457-06gwrpu0.txt plain text: cord-289457-06gwrpu0.txt item: #1433 of 2876 id: cord-289533-hip9qtu5 author: Smulever, Anabella title: Thyroid cancer in the Era of COVID-19 date: 2020-08-04 words: 2824 flesch: 36 summary: Although these studies show the first experiences related to COVID-19 in patients with cancer, probably the heterogeneous types of cancer, stages, and treatments would not allow drawing definitive conclusions than can be assumed in thyroid cancer patients. Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19) Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology on behalf of the TERAVOLT investigators: COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international Thyroid hormone action on innate immunity Modulating the function of the immune system by thyroid hormones and thyrotropin Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma The sympathetic nerveean integrative interface between two supersystems: the brain and the immune system Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations Thyroid disease in the time of COVID-19 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer Radioiodine-induced changes in lymphocyte subsets in patients with differentiated thyroid carcinoma Lindemann, Lymphocyte function following radioiodine therapy in patients with thyroid carcinoma Dynamic risk assessment in patients with differentiated thyroid cancer Suspicious cervical lymph nodes detected after thyroidectomy for papillary thyroid cancer usually remain stable over years in properly selected patients Hematologic toxicities in cancer patients treated with the multi-tyrosine kinase sorafenib: a meta-analysis of clinical trials A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma A phase 1 study of lenvatinib, multiple receptor tyrosine kinase inhibitor Covid-19 outbreak In Northern Italy: first practical indications for radiotherapy departments Author contributions All authors contributed to the study conception and design. keywords: cancer; covid-19; disease; infection; patients; risk; thyroid cache: cord-289533-hip9qtu5.txt plain text: cord-289533-hip9qtu5.txt item: #1434 of 2876 id: cord-289542-u86ujtur author: Razavian, Narges title: A validated, real-time prediction model for favorable outcomes in hospitalized COVID-19 patients date: 2020-10-06 words: 8075 flesch: 41 summary: To be effective, solutions involving machine learning must 4, 5 (1) address a clearly defined use case that clinical leaders will champion and (2) motivate changes in clinical management based on model predictions. These expected differences in model variables and outcomes challenge the generalizability of any predictive model, which emphasized the importance of prospective validation. keywords: care; covid-19; data; green; model; patients; performance; prediction; rate; risk; score; set; time; validation; variables cache: cord-289542-u86ujtur.txt plain text: cord-289542-u86ujtur.txt item: #1435 of 2876 id: cord-289553-gygvhzcc author: Alvarez, Roger A. title: Home Nitric Oxide Therapy for COVID-19 date: 2020-07-01 words: 1828 flesch: 31 summary: In a randomized and placebo-controlled trial of ambulatory patients with fibrotic lung disease requiring long-term oxygen, INOpulse therapy was associated with greater physical activity than placebo, and in an acute dose escalation study of patients with pulmonary hypertension associated with pulmonary fibrosis, iNO delivered through the INOpulse system lead to a 30% reduction in pulmonary vascular resistance, with improvements in Q _ and pulmonary artery compliance (15) . In Table 1 , we have summarized planned and ongoing clinical trials available that are testing NO gas therapy in COVID-19 patients. keywords: acute; ino; patients; risk; therapy cache: cord-289553-gygvhzcc.txt plain text: cord-289553-gygvhzcc.txt item: #1436 of 2876 id: cord-289574-engwi8h3 author: An, Peng-jiao title: Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications date: 2020-05-23 words: 3196 flesch: 30 summary: Unlike the cytokines profile of SARS patients, COVID-19 patients have a remarkable increase of anti-inflammatory cytokines IL-10 (Table 1) , which has been often seen in HLH patients in previous studies [61, 67, 68] . At the beginning of the epidemic, Huang et al reported that the plasma levels of IL2, IL7, GSCF, CXCL10, MCP1, MIP1A, and TNF-α were higher in COVID-19 patients in the intensive care unit (ICU) than those of COVID-19 patients outside the ICU keywords: cells; clinical; coronavirus; covid-19; cytokine; il-6; infection; patients; sars cache: cord-289574-engwi8h3.txt plain text: cord-289574-engwi8h3.txt item: #1437 of 2876 id: cord-289581-aozg3o9o author: None title: Abstracts der 54. Jahrestagung der Österreichischen Gesellschaft für Kinder- und Jugendheilkunde date: 2016-08-25 words: 16447 flesch: 49 summary: In der Typisierung der elterlichen und kindlichen Die Resultate der von uns durchgeführten Studie zeigen, dass die Prävalenz der DPN bei Kindern und Jugendlichen sehr hoch ist. keywords: age; als; alter; aortic; auch; auf; aufgrund; aus; background; bdg; bei; bei der; bis; children; conclusion; das; dass; dem; den; der; des; die; diese; disease; diskussion; durch; eine; einleitung; ergebnisse; erkrankungen; function; für; gabe; group; infants; insulin; ist; ivig; jugendlichen; kann; kinder; können; median; methoden; methods; mit; mittels; mtx; n =; nach; nicht; oder; ohne; patienten; patients; preterm; results; risk; schlussfolgerungen; score; sich; signifikant; sind; sowie; studie; study; syndrome; therapie; treatment; und; und diskussion; unter; von; vor; war; waren; werden; werte; wir; wird; wurde; years; zeigte; zur; zwischen; über cache: cord-289581-aozg3o9o.txt plain text: cord-289581-aozg3o9o.txt item: #1438 of 2876 id: cord-289612-4x5t4c5u author: Alsuliman, Tamim title: COVID-19 paraclinical diagnostic tools: Updates and future trends date: 2020-06-20 words: 7370 flesch: 45 summary: Therefore, it may be important to routinely detect viral RNA in stool specimens of COVID-19 patients during the hospitalization and recovery stage, and to perform transmission-based precautions for patients until the negative conversion of viral RNA in feces. Probably, combining RNA and antibody detections may significantly improve the sensitivity of pathogenic diagnosis for COVID-19 patients (p < 0.001), even in the early phase of 1-week since onset (p = 0.007). keywords: assay; cases; coronavirus; cov-2; covid-19; diagnosis; disease; infection; patients; pcr; results; rna; rrt; sars; study cache: cord-289612-4x5t4c5u.txt plain text: cord-289612-4x5t4c5u.txt item: #1439 of 2876 id: cord-289690-af6lsj1g author: Svobodova, Tamara title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 words: 3552 flesch: 37 summary: Chronic lung tissue changes and pulmonary alveolar proteinosis (PAP), as well as pulmonary arterial hypertension, have been described in adult patients [1, [7] [8] [9] . Despite the very low numbers of B cells, normal serum immunoglobulin levels of IgM and IgA and increased levels of IgG were present (23.6 g/l). keywords: cell; changes; deficiency; disease; ebv; gata-2; gata2; infection; lung; patient cache: cord-289690-af6lsj1g.txt plain text: cord-289690-af6lsj1g.txt item: #1440 of 2876 id: cord-289719-64ugdvfe author: Tenforde, Mark W. title: Characteristics of Adult Outpatients and Inpatients with COVID-19 — 11 Academic Medical Centers, United States, March–May 2020 date: 2020-07-03 words: 3172 flesch: 41 summary: Few studies have systematically collected data on COVID-19 patients from varied health care settings in the United States. A majority of COVID-19 patients reported working during the 2 weeks preceding illness, and few had the ability to telework, underscoring the need for enhanced measures to ensure workplace safety. keywords: cov-2; covid-19; outpatients; patients; sars; symptoms; testing cache: cord-289719-64ugdvfe.txt plain text: cord-289719-64ugdvfe.txt item: #1441 of 2876 id: cord-289775-40bi87iz author: Haines, David E. title: Heart Rhythm Society Expert Consensus Statement on Electrophysiology Laboratory Standards: Process, Protocols, Equipment, Personnel, and Safety date: 2014-05-07 words: 28552 flesch: 32 summary: Therefore, personnel dedicated to EP laboratory procedures are recommended. Although the risk of infection is extremely low with EP catheter procedures, 57 appropriate sterile techniques should be maintained. keywords: ablation; ablation procedures; american; anesthesia; area; cardiac; care; cases; catheter; catheter ablation; complications; control; data; device; dose; ep laboratory; ep patients; ep procedures; equipment; exposure; fluoroscopy; guidelines; health; heart; imaging; laboratories; lead; mapping; operator; patient; pediatric; physician; practice; process; radiation; requirements; risk; room; safety; sedation; staff; systems; time; training; use cache: cord-289775-40bi87iz.txt plain text: cord-289775-40bi87iz.txt item: #1442 of 2876 id: cord-289806-6ihptx6n author: Martinez, Rebecca title: Critical Obstetric Patients During the Coronavirus Disease 2019 Pandemic: Operationalizing an Obstetric Intensive Care Unit date: 2020-10-07 words: 3190 flesch: 35 summary: These paradigms are not unique to nursing; operating outside ones' scope of practice results in the delivery of care that is not as seamless as within teams that consistently work together with critical care patients. Leadership from the departments of anesthesia technicians, central venous access, extracorporeal membrane oxygenation (ECMO), facilities maintenance, ICU triage (adult and pediatric), nursing, nutrition, occupational and physical therapy, pharmacy, phlebotomy, respiratory therapy and social work committed to providing 24/7 coverage for OBICU patients should needs arise. keywords: anesthesia; attending; care; critical; nursing; obicu; obstetric; patients; team cache: cord-289806-6ihptx6n.txt plain text: cord-289806-6ihptx6n.txt item: #1443 of 2876 id: cord-289816-rlwoy8ms author: Tedeschi, Delio title: Acute myocardial infarction and large coronary thrombosis in a patient with COVID‐19 date: 2020-08-07 words: 1451 flesch: 30 summary: This case report highlights the clinical impact of ACS-STEMI in COVID-19 patients. This clinical case suggests that coronary thrombosis in COVID‐19 patients may be unresponsive to optimal pharmacological (GP IIb–IIIa infusion) and mechanical treatment (PCI). was transferred from another hospital to our institution. keywords: covid-19; infarction; patient; thrombosis cache: cord-289816-rlwoy8ms.txt plain text: cord-289816-rlwoy8ms.txt item: #1444 of 2876 id: cord-289828-3k088z9n author: De Salvo, Andrea title: How to be together and carry on our project activities during COVID‐19 pandemic in Rome date: 2020-08-03 words: 1052 flesch: 51 summary: Psychosocial dimensions of cancer in adolescents and young adults The experience of loneliness among young adult cancer patients Correlates of social support in young adults with advanced cancer Starting an adolescent and young adult program: some success stories and some obstacles to overcome Health and supportive care needs of young adult cancer patients and survivors Online communities as sources of peer support for people living with cancer: a commentary Internet-based program for coping with cancer: a randomized controlled trial with hematologic cancer patients Coping with cancer: a web-based educational program for early and middle adolescents Immediate psychological responses and associated factors during the initial stage of the 2019 coronavirus disease (COVID-19) epidemic among the general population in China Prevalence and correlates of high fear of cancer recurrence in late adolescents and young adults consulting a specialist adolescent and young adult (AYA) cancer service Recent research reported advantages of using online communities for patients with cancer. keywords: cancer; game; patients cache: cord-289828-3k088z9n.txt plain text: cord-289828-3k088z9n.txt item: #1445 of 2876 id: cord-289852-4uxb70rh author: Kassem, Dina H. title: Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis date: 2020-09-30 words: 6972 flesch: 34 summary: Thus, harnessing the immunomodulatory properties of mesenchymal stem cells (MSCs) to ameliorate that cytokine-storm can indeed provide a golden key for the treatment of COVID-19 patients, especially severe cases. Antimicrobial activity of mesenchymal stem cells: current status and new perspectives of antimicrobial peptide-based therapies Immunopathology of SARS-CoV-2 infection: immune cells and mediators, prognostic factors, and immune-therapeutic implications Corticosteroid therapy for critically Ill patients with middle east respiratory syndrome Mesenchymal stromal cell infusion modulates systemic immunological responses in stable COPD patients: a phase I pilot study Expanded umbilical cord mesenchymal stem cells (UC-MSCs) as a therapeutic strategy in managing critically ILL COVID-19 patients: the case for compassionate use Mesenchymal stem/stromal cell secretome for lung regeneration: the long way through pharmaceuticalization for the best formulation Human Wharton's jelly mesenchymal stem cells show unique gene expression compared with bone marrow mesenchymal stem cells using single-cell RNA-sequencing Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV Secretome of mesenchymal stromal cells prevents myofibroblasts differentiation by transferring fibrosis-associated microRNAs within extracellular vesicles Remdesivir for the treatment of covid-19 -preliminary report Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine -a new paradigm for tissue repair International society for extracellular vesicles and international society for cell and gene therapy statement on extracellular vesicles from mesenchymal stromal cells and other cells: considerations for potential therapeutic agents to suppress coronavirus disease-19 Pathogenic role of HMGB1 in SARS? keywords: cells; cov-2; covid-19; cytokine; et al; immune; infection; lung; mesenchymal; mscs; patients; sars; stem; storm cache: cord-289852-4uxb70rh.txt plain text: cord-289852-4uxb70rh.txt item: #1446 of 2876 id: cord-289854-p8okfa4b author: Flores, Gabriel title: Spontaneous Brainstem Hemorrhagic Stroke in the Setting of Novel Coronavirus Disease 2019 – A Case Report date: 2020-10-05 words: 1427 flesch: 38 summary: Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Hemorrhagic stroke and anticoagulation in COVID-19 COVID-19 and cerebral hemorrhage: proposed mechanisms (IN PRESS) COVID-19 and intracerebral haemorrhage: causative or coincidental Novel coronavirus disease 2019 and subarachnoid hemorrhage: a case report Neuroradiological features in COVID-19 patients: first evidence in a complex scenario (IN PRESS) Aphasia and cerebral haemorrhage complicating whooping-cough SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Angiotensin converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system Intracerebral hemorrhage without a bleeding diathesis has been reported only rarely in COVID-19 patients [4] . keywords: covid-19; hemorrhage; patients; risk cache: cord-289854-p8okfa4b.txt plain text: cord-289854-p8okfa4b.txt item: #1447 of 2876 id: cord-289859-b1k9uyp6 author: Hodges, Kevin title: Successful management of COVID‐19 and associated coagulopathy in a patient with durable left ventricular assist device date: 2020-08-13 words: 1058 flesch: 32 summary: 4, 5 These findings have prompted interest in the use of anticoagulation for management and prophylaxis in COVID-19 patients. We describe our institutional protocol for managing COVID‐19 infection in patients on mechanical circulatory support, focusing on the need for a thoughtful, multidisciplinary approach. keywords: covid-19; infection; management; patients cache: cord-289859-b1k9uyp6.txt plain text: cord-289859-b1k9uyp6.txt item: #1448 of 2876 id: cord-289930-7xm6q68s author: Li, Yang title: Corticosteroid prevents COVID-19 progression within its therapeutic window: a multicentre, proof-of-concept, observational study date: 2020-08-21 words: 4336 flesch: 38 summary: Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids benefits patients with LDH levels of less than two times the ULN, who may be in the early phase of excessive inflammation. Despite the fact that COVID-19 patients have mild symptoms and signs in their early stage, about 8-30% of patients would eventually develop severe illness. keywords: corticosteroids; disease; group; inflammation; patients; progression; study; window cache: cord-289930-7xm6q68s.txt plain text: cord-289930-7xm6q68s.txt item: #1449 of 2876 id: cord-289973-1mczuxsy author: Biran, Noa title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date: 2020-08-14 words: 5219 flesch: 38 summary: Patients who received tocilizumab showed a reduction in Creactive protein levels at 3, 7, and 14 days after administration of tocilizumab compared with patients who did not receive tocilizumab. key: cord-289973-1mczuxsy authors: Biran, Noa; Ip, Andrew; Ahn, Jaeil; Go, Ronaldo C; Wang, Shuqi; Mathura, Shivam; Sinclaire, Brittany A; Bednarz, Urszula; Marafelias, Michael; Hansen, Eric; Siegel, David S; Goy, Andre H; Pecora, Andrew L; Sawczuk, Ihor S; Koniaris, Lauren S; Simwenyi, Micky; Varga, Daniel W; Tank, Lisa K; Stein, Aaron A; Allusson, Valerie; Lin, George S; Oser, William F; Tuma, Roman A; Reichman, Joseph; Brusco, Louis; Carpenter, Kim L; Costanzo, Eric J; Vivona, Vincent; Goldberg, Stuart L title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study date: 2020-08-14 journal: The Lancet Rheumatology DOI: 10.1016/s2665-9913(20)30277-0 sha: doc_id: 289973 cord_uid: 1mczuxsy Summary Background Tocilizumab, a monoclonal antibody directed against the interleukin-6 receptor, has been proposed to mitigate the cytokine storm syndrome associated with severe COVID-19. keywords: covid19; data; health; icu; mortality; patients; propensity; protein; study; support; tocilizumab; treatment cache: cord-289973-1mczuxsy.txt plain text: cord-289973-1mczuxsy.txt item: #1450 of 2876 id: cord-290006-63sa00ju author: Ko, Jane P. title: Approach to Peribronchovascular Disease on CT date: 2018-12-20 words: 6396 flesch: 31 summary: Two radiologic patterns with a different prognosis Comparison of computed tomographic findings in pulmonary mucormycosis and invasive pulmonary aspergillosis Chronic pulmonary paracoccidioidomycosis (South American blastomycosis): High-resolution CT findings in 41 patients Radiographic and CT features of viral pneumonia Invasive pulmonary aspergillosis in acute leukemia: Characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis Role of procalcitonin in the management of infected patients in the intensive care unit A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the Diagnostic accuracy of xpert test in tuberculosis detection: A systematic review and metaanalysis Recent advances in diagnosing chronic pulmonary aspergillosis Beta-D-glucan testing is important for diagnosis of invasive fungal infections Role of serological tests in the diagnosis of mold infections Imaging of pulmonary vasculitis Pulmonary involvement in Churg-Strauss syndrome: An analysis of CT, clinical, and pathologic findings CT features of vasculitides based on the 2012 International Chapel Hill Consensus Conference Revised Classification The lung in systemic vasculitis: Radiological patterns and differential diagnosis Granulomatosis with polyangiitis (Wegener): Clinical aspects and treatment Pulmonary manifestations of wegener granulomatosis: CT findings in 57 patients and a review of the literature Thoracic manifestation of Churg-Strauss syndrome: Radiologic and clinical findings Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management Churg-Strauss syndrome: High resolution CT and pathologic findings Eosinophilic lung diseases: Diagnostic accuracy of thin-section CT in 111 patients Churg-Strauss syndrome: The spectrum of pulmonary CT findings in 17 patients Transbronchial lung biopsy for the diagnosis of IgG4-related lung disease IgG4-related Lung disease associated with autoimmune hemolytic anemia: Serial high-resolution CT findings in 22 patients Pneumonitis in non-small cell lung cancer patients receiving immune checkpoint immunotherapy: Incidence and risk factors Cryptogenic organizing pneumonia: CT findings in 43 patients Serial chest CT in cryptogenic organizing pneumonia: keywords: associated; disease; findings; infection; lung; lymphoma; nodules; organizing; patients; peribronchovascular; pneumonia; pulmonary cache: cord-290006-63sa00ju.txt plain text: cord-290006-63sa00ju.txt item: #1451 of 2876 id: cord-290028-oyd7vzj6 author: Unruh, Mark title: Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis date: 2020-10-20 words: 7695 flesch: 40 summary: Telehealth, a two-way video interaction between the patient and the therapist, overcomes accessibility challenges and has been identified by the American Academy of Sleep Medicine as having the potential to narrow the gap between the availability of sleep providers and the number of patients needing insomnia treatment Despite evidence for broad-ranging health effects of insomnia, very few clinical trials have tested the efficacy of treatments for HD patients. keywords: cbt; dialysis; hd patients; insomnia; participants; patients; placebo; sleep; study; therapy; trazodone; treatment; trial; use; week cache: cord-290028-oyd7vzj6.txt plain text: cord-290028-oyd7vzj6.txt item: #1452 of 2876 id: cord-290041-zxlq63n5 author: Srivastava, Arnav title: Delaying Surgery for Clinical T1b-T2bN0M0 Renal Cell Carcinoma: Oncologic Implications in the COVID-19 Era and Beyond date: 2020-10-20 words: 2996 flesch: 45 summary: The effect of surgical delay on kidney cancer outcomes has not been robustly evaluated. Specifically, we selected only those patients who underwent surgery to best model the effects of surgical delay on patients scheduled to receive surgery. keywords: delay; months; patients; staging; surgery; survival cache: cord-290041-zxlq63n5.txt plain text: cord-290041-zxlq63n5.txt item: #1453 of 2876 id: cord-290051-22gwwrpw author: Masaki, Shigenori title: Endotracheal intubation in patients with COVID-19 using an ultrathin flexible gastrointestinal endoscope date: 2020-10-16 words: 1275 flesch: 34 summary: Therefore, endotracheal intubation using this method may be useful in reducing the risk of exposure to severe acute respiratory syndrome coronavirus 2. Endotracheal intubation using an ultrathin flexible gastrointestinal endoscope is a quick and reliable procedure that can be performed while maintaining distance from the patient. Friedel D, Rawat K S-Editor: Zhang L L-Editor: A P-Editor: Wang LL Core Tip: Proximity of the operators to the patient is inevitable with conventional endotracheal intubation procedures. keywords: endotracheal; intubation cache: cord-290051-22gwwrpw.txt plain text: cord-290051-22gwwrpw.txt item: #1454 of 2876 id: cord-290065-ouua7wnq author: Kashi, Mahine title: Severe arterial thrombosis associated with Covid-19 infection date: 2020-05-16 words: 706 flesch: 35 summary: key: cord-290065-ouua7wnq authors: Kashi, Mahine; Jacquin, Aurélien; Dakhil, Bassel; Zaimi, Rym; Mahé, Emmanuel; Tella, Emilie; Bagan, Patrick title: Severe arterial thrombosis associated with Covid-19 infection date: 2020-05-16 journal: Thromb Res DOI: 10.1016/j.thromres.2020.05.025 sha: doc_id: 290065 cord_uid: ouua7wnq • Increased incidence of venous thrombosis has been demonstrated in SARS-CoV2 infected patients but no data are available for arterial thrombosis. We were also confronted with unusual extension or localization of arterial thrombosis diagnosed in a short period of time. keywords: covid-19; patients cache: cord-290065-ouua7wnq.txt plain text: cord-290065-ouua7wnq.txt item: #1455 of 2876 id: cord-290081-pjg00t7g author: Dunkerley, Sarah title: Patient care modifications and hospital regulations during the COVID-19 crisis created inequality and functional hazard for patients with orthopaedic trauma date: 2020-08-07 words: 2923 flesch: 53 summary: We prospectively analysed the outcomes of virtual fracture clinic patients from the 14th to the 28th of April, during peak lockdown. There is a large amount of evidence in the literature that virtual fracture clinics are a cost-efficient and cost-effective way of triaging trauma [2] [3] [4] [5] . keywords: clinic; face; follow; fracture; patients; time cache: cord-290081-pjg00t7g.txt plain text: cord-290081-pjg00t7g.txt item: #1456 of 2876 id: cord-290195-8uaai9nv author: Stebbing, Justin title: Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients date: 2020-05-30 words: 6616 flesch: 39 summary: Collectively, this limited case series provides preliminary evidence that baricitinib treatment may lower inflammatory burden and may result in a reduction in disease severity in COVID-19 patients. Following the recent publications by Stebbing et al.(Richardson et al., 2020a, Stebbing et al., 2020) , COVID-19 patients were treated with baricitinib in a pilot study in Milan, Italy. keywords: anti; baricitinib; cells; cov-2; covid-19; cytokine; data; disease; et al; fig; human; il-6; patients; sars; treatment cache: cord-290195-8uaai9nv.txt plain text: cord-290195-8uaai9nv.txt item: #1457 of 2876 id: cord-290200-csmisulw author: Friedlaender, Alex title: Rethinking the Optimal Duration of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer Throughout the COVID-19 Pandemic date: 2020-05-12 words: 4035 flesch: 41 summary: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Utility of incorporating next-generation sequencing (NGS) in an Asian nonsmall cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia Chemotherapy in combination with immune checkpoint inhibitors for the first-line treatment of patients with advanced non-small cell lung cancer: a systematic review and literaturebased meta-analysis Poor-performance status assessment of patients with non-small cell lung cancer remains vague and blurred in the immunotherapy era Pembrolizumab in patients with advanced non-small-cell lung cancer (KEYNOTE-001): 3-year results from an open-label, phase 1 study Five-year survival and correlates among patients with advanced melanoma, renal cell carcinoma, or nonsmall cell lung cancer treated with nivolumab CheckMate 153: randomized results of continuous vs 1-year fixed-duration nivolumab in patients with advanced non-small-cell lung cancer Five-year follow-up of nivolumab in previously treated advanced non-smallcell lung cancer: results from the CA209-003 study Long-term survival in patients with advanced non-small-cell lung cancer treated with atezolizumab versus docetaxel: results from the randomised phase III OAK study Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: a systematic review and meta-analysis Association of immune-related adverse events with nivolumab efficacy in non-small-cell lung cancer Association of checkpoint inhibitor-induced toxic effects with shared cancer and tissue antigens in non-small cell lung cancer Early immune-related adverse events and association with outcome in advanced non-small cell lung cancer patients treated with nivolumab: a prospective cohort study Evaluation of readministration of immune checkpoint inhibitors after immune-related adverse events in patients with cancer Three-year overall survival with durvalumab after chemoradiotherapy in stage III NSCLC-update from PACIFIC First subsequent treatment after discontinuation of durvalumab in unresectable, stage III NSCLC patients from PACIFIC Immunotherapy rechallenge after nivolumab treatment in advanced nonsmall cell lung cancer in the real-world setting: a national data base analysis Updated analysis of KEYNOTE-024: pembrolizumab versus platinumbased chemotherapy for advanced non-small-cell lung cancer with PD-L1 tumor proportion score of 50% or greater Costs and benefits of immunotherapies or depot medications for the treatment of drug abuse The activity of immune checkpoint inhibition in KRAS mutated non-small cell lung cancer: a single centre experience KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures Implementation of National Institute for Health and Care Excellence (NICE) Technology Assessment Guidance (TAG) 557: pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer (NSCLC)-successes and challenges in a cancer unit Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study Discontinuation of anti-PD-1 antibody therapy in the absence of disease progression or treatment limiting toxicity: clinical outcomes in advanced melanoma Early assessment of lung cancer immunotherapy response via circulating tumor DNA Circulating tumor DNA analysis to assess risk of progression after long-term response to PD-(L) 1 blockade in NSCLC Tissue-plasma TMB comparison and plasma TMB monitoring in patients with metastatic non-small cell lung cancer receiving immune checkpoint inhibitors Tumor mutation burden-from hopes to doubts Nivolumab plus ipilimumab in advanced non-small-cell lung cancer Association of the lung immune prognostic index with immune checkpoint inhibitor outcomes in patients with advanced non-small cell lung cancer Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Thoracic cancERs international coVid 19 cOLlaboraTion): First results of a global collaboration to address the impact of COVID-19 in patients with thoracic malignancies Expert recommendations on the management of patients with advanced non-small cell lung cancer during epidemic of COVID-19 (trial version). How we treat patients with lung cancer during the SARS-CoV-2 pandemic: primum non nocere Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates Immunotherapy in non-small-cell lung cancer patients with performance status 2: clinical decision making with scant evidence Pembrolizumab in patients with non-small-cell lung cancer of performance status 2 (PePS2): a single arm, phase 2 trial First-line pembrolizumab in advanced non-small cell lung cancer patients with poor performance status All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication. keywords: cancer; cell; duration; icpi; lung; patients; therapy; treatment cache: cord-290200-csmisulw.txt plain text: cord-290200-csmisulw.txt item: #1458 of 2876 id: cord-290267-ke696q8j author: Fang, Huilin title: Impact of comorbidities on clinical prognosis in 1280 patients with different types of COVID-19 date: 2020-10-13 words: 4882 flesch: 39 summary: Compared with ordinary patients, a significantly greater proportion of critical patients experienced cough (76.6% vs 65.6%, p<0.05), sputum production (28.2% vs 16 was significantly lower than that of ordinary and severe patients (25.0% vs 73.0%, 55.1%; p<0.05), and the cure rate of severe patients was also significantly lower than that of ordinary patients (73.0% vs 55.1%, p<0.05). In addition, the mortality rate of critical patients was significantly higher than that of ordinary and severe patients (47.6% vs 0.4%, 1.9%; p<0.05), and the mortality rate of severe patients was also significantly higher than that of ordinary patients (1.9% vs 0.4%, p<0.05). keywords: comorbidities; covid-19; diabetes; hypertension; p<0.05; patients; rate cache: cord-290267-ke696q8j.txt plain text: cord-290267-ke696q8j.txt item: #1459 of 2876 id: cord-290295-gl144dh9 author: Martínez-López, Joaquín title: Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality date: 2020-10-19 words: 4091 flesch: 30 summary: To our knowledge, this is the first large case-series study to describe comprehensively the clinical characteristics of COVID-19 in hospitalized MM patients, compare outcomes with a noncancer cohort of COVID-19 patients, and identify preadmission prognostic factors of inpatient mortality. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. keywords: covid-19; disease; factors; hospital; inpatient; mortality; myeloma; noncancer; patients cache: cord-290295-gl144dh9.txt plain text: cord-290295-gl144dh9.txt item: #1460 of 2876 id: cord-290326-umv0q4d7 author: Stachowska, Ewa title: Nutritional Support in Coronavirus 2019 Disease date: 2020-06-12 words: 5121 flesch: 32 summary: A meta-analysis conducted in ICU patients demonstrated that early enteral nutrition within 24 h of ICU admission reduced mortality compared with delayed enteral intake (odds ratio, 0.45; 95% CI, 0.21-0.95, p = 0.038) The data on nutritional support in COVID-19 patients is still elusive. keywords: body; care; coronavirus; covid-19; energy; icu; infection; nutrition; patients; protein; risk; therapy cache: cord-290326-umv0q4d7.txt plain text: cord-290326-umv0q4d7.txt item: #1461 of 2876 id: cord-290341-ei768v4s author: Anstey, D. Edmund title: The cardiac intensive care unit and the cardiac Intensivist during the COVID-19 surge in New York City() date: 2020-07-03 words: 4213 flesch: 38 summary: Further, if a high volume of COVID-19 patients are anticipated, efforts can be made to re-construct rooms to be negative pressure. This period has also seen an increase in the number of CICU patients present with primary non-cardiac illnesses but with underlying cardiac disease. keywords: cardiac; care; cicu; clinical; covid-19; pandemic; patients; team cache: cord-290341-ei768v4s.txt plain text: cord-290341-ei768v4s.txt item: #1462 of 2876 id: cord-290401-t87i3exo author: Bassetti, Matteo title: Principles of antimicrobial stewardship for bacterial and fungal infections in ICU date: 2017-09-12 words: 1641 flesch: 30 summary: Despite the lack of randomized trials, antifungal therapy for patients with complicated intra-abdominal infection is recommended when Candida spp. -d-Glucan and Candida albicans germ tube antibody in ICU patients with invasive candidiasis Antifungal de-escalation was not associated with adverse outcome in critically ill patients treated for invasive candidiasis: post hoc analyses of the AmarCAND2 study data keywords: control; infection; mortality; patients; source cache: cord-290401-t87i3exo.txt plain text: cord-290401-t87i3exo.txt item: #1463 of 2876 id: cord-290551-a02tueuu author: Singh, Shailendra title: Impact of Obesity on Outcomes of Patients with COVID-19 in United States: A Multicenter Electronic Health Records Network Study. date: 2020-08-21 words: 2720 flesch: 49 summary: Our study using a large nationally representative database showed that COVID-19 patients with any degree of obesity had a significantly higher risk of hospitalization and intubation or death compared to patients without obesity. Advanced age and male gender are major risk factors for worse prognosis and higher mortality in COVID-19 patients 6 . keywords: covid-19; data; diagnosis; group; obesity; patients; risk cache: cord-290551-a02tueuu.txt plain text: cord-290551-a02tueuu.txt item: #1464 of 2876 id: cord-290611-fhaguv3f author: Ghio, Stefano title: Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy date: 2020-09-22 words: 3763 flesch: 38 summary: key: cord-290611-fhaguv3f authors: Ghio, Stefano; Baldi, Enrico; Vicentini, Alessandro; Lenti, Marco Vincenzo; Di Sabatino, Antonio; Di Matteo, Angela; Zuccaro, Valentina; Piloni, Davide; Corsico, Angelo; Gnecchi, Massimiliano; Speciale, Francesco; Sabena, Anna; Oltrona Visconti, Luigi; Perlini, Stefano title: Cardiac involvement at presentation in patients hospitalized with COVID-19 and their outcome in a tertiary referral hospital in Northern Italy date: 2020-09-22 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02493-y sha: doc_id: 290611 cord_uid: fhaguv3f The correlation between myocardial injury and clinical outcome in COVID-19 patients is gaining attention in the literature. This datum, together with the observation that patients with elevated hs-TnI values at admission had laboratory and respiratory function data indicative of a more severe systemic infection, would support hypothesis that the increase of hs-TnI levels in COVID-19 patients is mainly the consequence of a more severe systemic disease rather being indicative of primary cardiac injury, as already described in the literature [19] . keywords: covid-19; hospital; patients; tni; values cache: cord-290611-fhaguv3f.txt plain text: cord-290611-fhaguv3f.txt item: #1465 of 2876 id: cord-290658-r2bqqovo author: Qian, Hao title: Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: a Retrospective in-ICU Study date: 2020-10-16 words: 3559 flesch: 38 summary: Consistently, the in-ICU cumulative survival curve of myocardial injury patients was significantly lower than that of non-myocardial injury patients (HR, 2.200; 95% CI 1.29 to 3.74; P=0.004) ( Figure 2b ). The only significant difference in therapy was that more non-myocardial injury patients received anticoagulation therapy than myocardial injury patients (69.4% vs. 39.0%, P<0.01) ( Table 2) . keywords: admission; covid-19; icu; injury; mortality; patients; study cache: cord-290658-r2bqqovo.txt plain text: cord-290658-r2bqqovo.txt item: #1466 of 2876 id: cord-290712-flj352ql author: Bi, Jianping title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? date: 2020-09-04 words: 1347 flesch: 38 summary: key: cord-290712-flj352ql authors: Bi, Jianping; Ma, Hong; Zhang, Dongsheng; Huang, Jing; Yang, Dongqin; Wang, Yajie; Verma, Vivek; Zhang, Tao; Hu, Desheng; Mei, Qi; Han, Guang; Li, Jian title: Does Chemotherapy Reactivate SARS-CoV-2 in Cancer Patients Recovered from Prior COVID-19 Infection? date: 2020-09-04 journal: Eur Respir J DOI: 10.1183/13993003.02672-2020 sha: doc_id: 290712 cord_uid: flj352ql Recovered COVID-19 cancer patients remain negative for SARS-CoV-2 after delivery of chemotherapy To the Editor: Cancer patients are particularly vulnerable to coronavirus disease 2019 (COVID-19) (1) (2) (3) . To our knowledge, this is the first study reporting that recovered COVID-19 cancer patients remain negative in the short-term for SARS-CoV-2 after delivery of chemotherapy. keywords: chemotherapy; covid-19; patients cache: cord-290712-flj352ql.txt plain text: cord-290712-flj352ql.txt item: #1467 of 2876 id: cord-290750-85731og8 author: Danese, Silvio title: Management of IBD during the COVID-19 outbreak: resetting clinical priorities date: 2020-03-25 words: 1800 flesch: 37 summary: United Eur Update on COVID19 for Patients with Crohn's Disease and Ulcerative Colitis Implications of COVID-19 for patients with pre-existing digestive diseases Advice on the use of masks in the community, during home care and in health care settings in the context of the novel coronavirus (2019-nCoV) outbreak: interim guidance has served as a Consultant or speaker for Ethicon, Frankenman, Oasis, Pfizer, Takeda and Sofar. As timely surgery is the other mainstay of IBD care, it is of deep concern that stopping scheduled surgery completely for several weeks for patients with IBD (allowing only oncological cases to undergo surgery) will soon result in increased numbers of emergency presentations and more complications from treatment delay. keywords: clinical; covid-19; disease; ibd; patients cache: cord-290750-85731og8.txt plain text: cord-290750-85731og8.txt item: #1468 of 2876 id: cord-290771-18dj37dj author: Tzeng, Ching-Wei D. title: Cancer Surgery Scheduling During and After the COVID-19 First Wave: The MD Anderson Cancer Center Experience date: 2020-05-18 words: 4872 flesch: 33 summary: Head and neck surgical oncology in the time of a pandemic: Subsite-specific triage guidelines during the COVID-19 pandemic Changing practice patterns in head & neck oncologic surgery in the early COVID-19 era Safety recommendations for evaluation and surgery of the head and neck during the COVID-19 pandemic Thoracic Surgery Outcomes Research Network Inc. COVID-19 guidance for triage of operations for thoracic malignancies: a consensus statement from thoracic surgery outcomes research network Management of cancer surgery cases during the COVID-19 pandemic: considerations COVID-19: Elective Case Triage Guidelines for Surgical Care Approaching surgical triage during the COVID-19 pandemic Surgical decision-making and prioritization for cancer patients at the onset of the COVID-19 pandemic: a multidisciplinary approach Neoadjuvant chemotherapy or primary surgery in stage IIIC or IV ovarian cancer Survival implications of time to surgical treatment of endometrial cancers Urology practice during COVID-19 pandemic COVID-19 Resources: Disease-Site Specific Management Resources Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. Based on early case reports, cancer patients with COVID-19 used greater hospital resources including ICU beds with higher mortality rates than the general population. keywords: april; cancer; care; case; chemotherapy; covid-19; disease; hospital; operations; patients; review; risk; surgery cache: cord-290771-18dj37dj.txt plain text: cord-290771-18dj37dj.txt item: #1469 of 2876 id: cord-290832-zmj59rc3 author: Recinella, Guerino title: Prognostic role of nutritional status in elderly patients hospitalized for COVID-19: a monocentric study date: 2020-10-08 words: 2989 flesch: 41 summary: We, therefore, believe that maximum attention should be paid to COVID-19 elderly patient with malnutrition and where possible start quickly a supplementary feeding. The association of GNRI with a respiratory parameter (PaO2/FiO2) provides a comprehensive prognostic tool for predicting adverse outcomes in elderly COVID-19 patients. keywords: covid-19; gnri; hospital; patients; risk; status; study cache: cord-290832-zmj59rc3.txt plain text: cord-290832-zmj59rc3.txt item: #1470 of 2876 id: cord-290836-jldfrec9 author: Laosa, Olga title: Rapid assessment at hospital admission of mortality risk from COVID-19: the role of functional status date: 2020-10-08 words: 1862 flesch: 50 summary: The role of functional status in determining poor outcomes in old patients with COVID- 46 19 has not been yet firmly established. key: cord-290836-jldfrec9 authors: Laosa, Olga; Pedraza, Laura; Álvarez-Bustos, Alejandro; Carnicero, Jose A.; Rodriguez-Artalejo, Fernando; Rodriguez-Mañas, Leocadio title: Rapid assessment at hospital admission of mortality risk from COVID-19: the role of functional status date: 2020-10-08 journal: J Am Med Dir Assoc DOI: 10.1016/j.jamda.2020.10.002 sha: doc_id: 290836 cord_uid: jldfrec9 Objective To evaluate the role of functional status along with other used clinical factors on the occurrence of death in patients hospitalized with COVID-19. keywords: covid-19; mortality; patients; risk; study cache: cord-290836-jldfrec9.txt plain text: cord-290836-jldfrec9.txt item: #1471 of 2876 id: cord-290856-6de0mwg0 author: Abbo, Aharon (Ronnie) title: Technological Developments and Strategic Management for Overcoming the COVID-19 Challenge within the Hospital Setting in Israel date: 2020-07-31 words: 4154 flesch: 33 summary: The system is currently being investigated in COVID-19 patients as a tool that could potentially assist in following up the respiratory status of the COVID-19 patients and assist in managing those who require mechanical ventilation. The use of existing ultrasound systems (point-of-care ultrasound [POCUS], handheld) to assess patient pulmonary status and diagnose lung pathologies has been reported in COVID-19 patients. keywords: care; control; covid-19; disease; health; hospital; medical; monitoring; patients; system; teams; temperature cache: cord-290856-6de0mwg0.txt plain text: cord-290856-6de0mwg0.txt item: #1472 of 2876 id: cord-290947-5ewpvo4j author: Carda, Stefano title: The role of physical and rehabilitation medicine in the COVID-19 pandemic: the clinician's view date: 2020-04-18 words: 1550 flesch: 35 summary: Cureus The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients A first Case of Meningitis/Encephalitis associated with SARS-Coronavirus-2 Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome Recovery from Dysphagia Symptoms after Oral Endotracheal Intubation in Acute Respiratory Distress Syndrome Survivors. A 5-Year Longitudinal Study Clinical observation and management of COVID-19 patients. keywords: covid-19; patients; pmr; rehabilitation; sato2 cache: cord-290947-5ewpvo4j.txt plain text: cord-290947-5ewpvo4j.txt item: #1473 of 2876 id: cord-290975-2kmvyovm author: Martinotti, Giovanni title: Psychopathological Burden and Quality of Life in Substance Users During the COVID-19 Lockdown Period in Italy date: 2020-09-03 words: 4251 flesch: 34 summary: Minerva Cardioangiol COVID-19 outbreak: Challenges for Addiction services in India Mitigating and learning from the impact of COVID-19 infection on addictive disorders Editorial: Challenges to Opioid Use Disorders During COVID-19 Opioid use disorder and the COVID 19 pandemic: A call to sustain regulatory easements and further expand access to treatment A clinical scale for the self-assessment of irritability A Rating Instrument For Anxiety Disorders Assessment of a new self-rating scale for post-traumatic stress disorder Manual for Beck Depression Inventory-II Validation of a substance craving questionnaire (SCQ) in Italian population The psychological impact of quarantine and how to reduce it: rapid review of the evidence Epidemic of COVID-19 in China and associated Psychological Problems Comparison of Prevalence and Associated Factors of Anxiety and Depression among People Affected by versus People Unaffected by Quarantine during the COVID-19 Epidemic in Southwestern China Mental Health, Risk Factors, and Social Media Use During the COVID-19 Epidemic and Cordon Sanitaire Among the Community and Health Professionals in Wuhan, China: Cross-Sectional Survey A longitudinal study on the mental health of general population during the COVID-19 epidemic in China A nationwide survey of psychological distress among italian people during the covid-19 pandemic: Immediate psychological responses and associated factors Mental health consequences during the initial stage of the 2020 Coronavirus pandemic (COVID-19) in Spain Transcranial Direct Current Stimulation Reduces Craving in Substance Use Disorders: A Double-blind, Placebo-Controlled Study Alcohol urges in alcohol-dependent drinkers: Further validation of the Alcohol Urge Questionnaire in an untreated community clinical population Craving and Other Transdiagnostic Dimensions in Addiction: Toward Personalized Neuromodulation Treatments Psychological stress, drug-related cues and cocaine craving Ecological momentary assessment of the effects of craving and affect on risk for relapse during substance abuse treatment Breaking good: Breaking ties with social groups may be good for recovery from substance misuse Medicines and risk/benefit decisions Association between alcohol craving and health-related quality of life among veterans with cooccurring conditions Effects of Exercise on Depression, Anxiety, Cognitive Control, Craving, Physical Fitness and Quality of Life in Methamphetamine-Dependent Patients Stress, craving and mood as predictors of early dropout from opioid agonist therapy Effects of anxiety and mood disorders on craving and substance use among patients with substance use disorder: An ecological momentary assessment study The association between depression and craving in alcohol dependency is moderated by gender and by alexithymia factors Telepsychiatry and other cutting edge technologies in Covid-19 pandemic: bridging the distance in mental health assistance Such a notion is relevant because substance craving is a known predictor of relapse after treatment for SUDs (36) . keywords: anxiety; covid-19; craving; health; life; pandemic; patients; study; substance; symptoms cache: cord-290975-2kmvyovm.txt plain text: cord-290975-2kmvyovm.txt item: #1474 of 2876 id: cord-291016-c83fs5ih author: Gori, Tommaso title: Perspective: cardiovascular disease and the Covid-19 pandemic date: 2020-04-10 words: 1624 flesch: 36 summary: Cardiovascular disease patients are at particularly high risk for mortality from Covid-19 due to their frailty and susceptibility for a myocardial involvement [1] . In addition, drugs used to treat Covid-19 patients have cardiovascular side effects (Table 1) , the burden of which will unfortunately need to be evaluated in retrospect. keywords: covid-19; disease; patients; risk; sars cache: cord-291016-c83fs5ih.txt plain text: cord-291016-c83fs5ih.txt item: #1475 of 2876 id: cord-291024-9g4om4sf author: Isakbaeva, Elmira T. title: SARS-associated Coronavirus Transmission, United States date: 2004-02-17 words: 3673 flesch: 48 summary: Communicable Disease Surveillance and Response (CSR) Cluster of severe acute respiratory syndrome cases among protected health care workers-Toronto A cluster of cases of severe acute respiratory syndrome in Hong Kong Outbreak of severe acute respiratory syndrome (SARS) at Amoy Gardens, Kowloon Bay, Hong Kong: main findings of the investigation Severe acute respiratory syndrome-Singapore Updated interim surveillance case definition for severe acute respiratory syndrome (SARS)-United States Interim laboratory biosafety guidelines for handling and processing specimens associated with severe acute respiratory syndrome (SARS) Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong Clinical course and management of SARS in health care workers in Toronto: a case series Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective investigation Address for correspondence: Elmira Isakbaeva Routine collection and testing of stool and sputum specimens of probable SARS case-patients may help the early detection of SARS-CoV infection. keywords: case; cov; household; illness; patient; sars; specimens cache: cord-291024-9g4om4sf.txt plain text: cord-291024-9g4om4sf.txt item: #1476 of 2876 id: cord-291025-u5z8zji3 author: Karami, Parisa title: Mortality of a pregnant patient diagnosed with COVID-19: A case report with clinical, radiological, and histopathological findings date: 2020-04-11 words: 2883 flesch: 45 summary: According to the released data to that date and considering the imaging findings on COVID-19 patients, results belonging to this patient were nonspecific for early stages of COVID -19 pneumonia. So far, few reports have provided information on the clinical and imaging follow up of pregnant patients with COVID-19. keywords: coronavirus; covid-19; disease; findings; patient cache: cord-291025-u5z8zji3.txt plain text: cord-291025-u5z8zji3.txt item: #1477 of 2876 id: cord-291052-nstfe15a author: Cag, Yasemin title: A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort date: 2020-08-27 words: 1937 flesch: 50 summary: In other words, if not correctly managed, this panic had the potential to consume hospital resources reserved for severe patients. key: cord-291052-nstfe15a authors: Cag, Yasemin; Icten, Sacit; Isik-Goren, Burcu; Baysal, Naciye Betul; Bektas, Begum; Selvi, Ece; Ergen, Pinar; Aydin, Ozlem; Ucisik, Ayse Canan; Yilmaz-Karadag, Fatma; Caskurlu, Hulya; Akarsu-Ayazoglu, Tulin; Kocoglu, Hasan; Uzman, Sinan; Nural-Pamukcu, Muge; Arslan, Ferhat; Bas, Gurhan; Kalcioglu, Mahmut Tayyar; Vahaboglu, Haluk title: A novel approach to managing COVID-19 patients; results of lopinavir plus doxycycline cohort date: 2020-08-27 journal: keywords: cases; covid-19; doxycycline; lopinavir; patients; treatment cache: cord-291052-nstfe15a.txt plain text: cord-291052-nstfe15a.txt item: #1478 of 2876 id: cord-291168-4u4cssky author: Martin-Villares, Cristina title: Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain date: 2020-08-04 words: 3223 flesch: 46 summary: To the best of our knowledge, this is the largest cohort of COVID-19 patients undergoing tracheostomy. In this pandemic scenario, with limited ICUs resources [10] , tracheostomy seems to help COVID-19 patients to get off the mechanical ventilation [11] , reducing the respiratory effort in patients with limited pulmonary reserves, shortening the dead space and enabling the suctioning of accumulated mucous. keywords: covid-19; data; hospital; pandemic; patients; tracheostomies; tracheostomy; ventilation; weaning cache: cord-291168-4u4cssky.txt plain text: cord-291168-4u4cssky.txt item: #1479 of 2876 id: cord-291176-evb6yt0r author: Giorgi Rossi, Paolo title: Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date: 2020-08-27 words: 4569 flesch: 42 summary: key: cord-291176-evb6yt0r authors: Giorgi Rossi, Paolo; Marino, Massimiliano; Formisano, Debora; Venturelli, Francesco; Vicentini, Massimo; Grilli, Roberto title: Characteristics and outcomes of a cohort of COVID-19 patients in the Province of Reggio Emilia, Italy date: 2020-08-27 journal: PLoS One DOI: 10.1371/journal.pone.0238281 sha: doc_id: 291176 cord_uid: evb6yt0r This is a population-based prospective cohort study on archive data describing the age- and sex-specific prevalence of COVID-19 and its prognostic factors. The cohort of COVID-19 patients includes all symptomatic patients who tested positive with PCR between February 27 and April 2, 2020. keywords: age; covid-19; death; disease; hospitalization; patients; risk; study cache: cord-291176-evb6yt0r.txt plain text: cord-291176-evb6yt0r.txt item: #1480 of 2876 id: cord-291244-o4isx15k author: Ikuyama, Yuichi title: Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date: 2020-05-31 words: 2390 flesch: 41 summary: China Novel Coronavirus Investigating and Research Team, A Novel Coronavirus from Patients with Pneumonia in China China Medical Treatment Expert Group for Covid-19, Clinical Characteristics of Coronavirus Disease 2019 in China Clinical features of patients infected with 2019 novel coronavirus in Characteristics of and Important Lessons From the Coronavirus 19 COVID-19) Outbreak in China: So far, there are few reports on critical patients with COVID-19 [2, [5] [6] [7] . keywords: clinical; coronavirus; covid-19; ecmo; patient; pneumonia; treatment cache: cord-291244-o4isx15k.txt plain text: cord-291244-o4isx15k.txt item: #1481 of 2876 id: cord-291265-qmylxndp author: Moravvej, Zahra title: COVID-19 pandemic: Ophthalmic practice and precautions in a tertiary eye hospital in Iran date: 2020-04-23 words: 1223 flesch: 46 summary: 4 Cases of conjunctivitis have been reported in COVID-19 patients. Medical specialties involve various examinations that may put patients and practitioners at risk of infection. keywords: covid-19; eye; hospital; infection; patients cache: cord-291265-qmylxndp.txt plain text: cord-291265-qmylxndp.txt item: #1482 of 2876 id: cord-291340-8gj0ofmp author: Misra, Anoop title: Balanced Nutrition is Needed in Times of COVID19 Epidemic in India: A Call for Action for all Nutritionists and Physicians date: 2020-08-27 words: 2151 flesch: 33 summary: In such patients mega doses are required in grams [23] . In this context proteins, vitamins, minerals, trace elements, prebiotics, probiotics, omega-3 polyunsaturated fatty acids and specific diets have been researched, but direct research on COVID19 patients are lacking. keywords: covid-19; covid19; diabetes; infections; mortality; nutrients; patients; vitamin cache: cord-291340-8gj0ofmp.txt plain text: cord-291340-8gj0ofmp.txt item: #1483 of 2876 id: cord-291388-tt9eq7e0 author: Wang, Jann-Tay title: Clinical Manifestations, Laboratory Findings, and Treatment Outcomes of SARS Patients date: 2004-05-17 words: 4357 flesch: 47 summary: We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital from March 8 to June 15, 2003. We conducted a prospective study on the clinical, radiologic, and hematologic findings of SARS patients with pneumonia, who were admitted to National Taiwan University Hospital (NTUH) from March 8 to June 15, 2003 . keywords: crp; death; disease; findings; level; patients; sars; study cache: cord-291388-tt9eq7e0.txt plain text: cord-291388-tt9eq7e0.txt item: #1484 of 2876 id: cord-291397-look6ddt author: Roberto, Palumbo title: Current treatment of COVID-19 in renal patients: hope or hype? date: 2020-09-28 words: 5842 flesch: 41 summary: Chloroquine is a potent inhibitor of SARS coronavirus infection and spread State Administration of Traditional Chinese Medicine (Trial Version 7) Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro RETRACTED: Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis Effect of high vs low doses of chloroquine diphosphate as adjunctive therapy for patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a randomized clinical trial Zika virus cell tropism in the developing human brain and inhibition by azithromycin Evaluation of Ebola virus inhibitors for drug repurposing Saudi critical care trials group, macrolides in critically ill patients with middle east respiratory syndrome Azithromycin for hospitalized patients with suspected or confirmed COVID-19, HAHPS (NCT04329832) Latest version Azithromycin for COVID-19 Treatment in Outpatients Nationwide, ACTION (NCT04332107) Latest version Surviving sepsis campaign: guidelines on the management of critically Ill adults with coronavirus disease 2019 (COVID-19) key: cord-291397-look6ddt authors: Roberto, Palumbo; Francesco, Londrino; Emanuela, Cordova; Giorgia, Gambardella; Pasquale, Niscola; Sara, Dominijanni title: Current treatment of COVID-19 in renal patients: hope or hype? date: 2020-09-28 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02510-0 sha: doc_id: keywords: clinical; coronavirus; cov-2; covid-19; disease; dose; infection; patients; pneumonia; renal; sars; treatment; use cache: cord-291397-look6ddt.txt plain text: cord-291397-look6ddt.txt item: #1485 of 2876 id: cord-291413-cgec7150 author: Al-Jehani, Hosam title: MENA-SINO Consensus Statement on Implementing Care Pathways for Acute Neurovascular Emergencies During the COVID-19 Pandemic date: 2020-08-25 words: 3767 flesch: 44 summary: Published and anecdotal reports suggest that during the pandemic, there has been a drastic reduction in the number of stroke patients being evaluated in the emergency room (ER) or being admitted to hospitals worldwide (6) . In theory, monitored anesthesia care (MAC) may prevent intense aerosolization; however, stroke patients undergoing MAC sedation may require supplemental oxygen via a nasal cannula mask or other methods, such as chin-lift or jaw thrust maneuvers, to improve oxygenation, which may increase the degree of airborne exposure to the anesthesia provider and other involved HCWs. keywords: care; challenges; covid-19; medical; pandemic; patients; stroke cache: cord-291413-cgec7150.txt plain text: cord-291413-cgec7150.txt item: #1486 of 2876 id: cord-291417-p49ukyhx author: Mikulska, Malgorzata title: Tocilizumab and steroid treatment in patients with COVID-19 pneumonia date: 2020-08-20 words: 4449 flesch: 38 summary: Indeed, some real life experiences in COVID-19 patients showed that the use of antiinflammatory treatments might be beneficial [12] . The OW-weighted Cox proportional hazard regression model was used to calculate the adjusted hazard-ratio (HR OW ) of tocilizumab/methylprednisolone/SOC vs SOC patients. keywords: covid-19; days; failure; methylprednisolone; patients; pneumonia; soc; tocilizumab; treatment cache: cord-291417-p49ukyhx.txt plain text: cord-291417-p49ukyhx.txt item: #1487 of 2876 id: cord-291430-rsu6xviv author: Zhang, Qian title: A Mysterious Paratracheal Mass: Parathyroid Carcinoma date: 2020-07-11 words: 1778 flesch: 45 summary: Parathyroid carcinoma patients had larger tumor sizes, higher mean serum calcium and PTH levels, and also had a higher incidence for hypercalcemic crisis comparing to patients with atypical adenomas. He was subsequently found to have parathyroid carcinoma as the cause of the acute encephalopathy with impressive serum calcium and parathyroid hormone levels. keywords: calcium; carcinoma; patient; serum cache: cord-291430-rsu6xviv.txt plain text: cord-291430-rsu6xviv.txt item: #1488 of 2876 id: cord-291469-cohrewj5 author: Cortese, Bernardo title: How is the cardiovascular patient managed during Covid‐19 pandemic? A report from the frontline date: 2020-05-20 words: 491 flesch: 50 summary: His father had died of sudden death after 3 days of remittent chest pain and dyspnea, but did not come to our emergency room for the Luckily, we expect that the vast majority of patients with cardiovascular disease in the Covid-era will survive, and will ultimately develop heart failure in the next few months. Which means that other areas, including Cardiovascular Departments, will go on suffering of this shift in resources, despite the restart of normal routine and expected increase in heart failure patients. keywords: pandemic; patients cache: cord-291469-cohrewj5.txt plain text: cord-291469-cohrewj5.txt item: #1489 of 2876 id: cord-291566-jwlvustd author: Wells Mulherin, Diana title: ASPEN Report on Nutrition Support Practice Processes With COVID‐19: The First Response date: 2020-07-16 words: 5732 flesch: 47 summary: Other clinicians are reporting a decrease in new home PN patients over the past few months, and patients receiving home PN are unable to get routine procedures and diagnostic tests. Information to support home PN patients is generally available electronically, such as medical records, patient laboratory results, and education information, and thus minimal changes to workflows were needed. keywords: care; clinicians; covid-19; home; hospital; nutrition; patients; support; team; time; use cache: cord-291566-jwlvustd.txt plain text: cord-291566-jwlvustd.txt item: #1490 of 2876 id: cord-291588-tp89j1kk author: Dorche, Maryam Sharifian title: Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic date: 2020-08-07 words: 5613 flesch: 31 summary: Front Public Health Acute Vision Loss in a Patient with COVID-19 Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report Quantitative evaluation of olfactory dysfunction in hospitalized patients with Coronavirus [2] (COVID-19) Bilateral transient olfactory bulbs edema during COVID-19-related anosmia Anosmia and olfactory tract neuropathy in a case of COVID-19 Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia Olfactory Bulb Magnetic Resonance Imaging in SARS-CoV-2-Induced Anosmia: The First Report Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients Anosmia and ageusia: common findings in COVID-19 patients younger age in ambulatory settings -a multicenter cross-sectional study COVID-19 presenting with ophthalmoparesis from cranial nerve palsy COVID-19 and herpes zoster co-infection presenting with trigeminal neuropathy Pearls and Oy-sters: Facial nerve palsy as a neurological manifestation of Covid-19 infection Guillain Barre syndrome associated with COVID-19 infection: A case report Early Guillain-Barré syndrome in coronavirus disease 2019 (COVID-19): a case report from an Italian COVID-hospital COVID-19 may induce Guillain-Barré syndrome Guillain-Barré syndrome related to COVID-19 infection Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Covid-19 and Guillain-Barré syndrome: More than a coincidence! In COVID-19 patients, possible mechanisms include infections, parenchymal damages, electrolyte imbalance, hypoxic, toxic and metabolic encephalopathies and non-convulsive status epilepticus. keywords: acute; barré; case; coronavirus; cov-2; covid-19; disease; guillain; infection; patients; sars; studies; syndrome cache: cord-291588-tp89j1kk.txt plain text: cord-291588-tp89j1kk.txt item: #1491 of 2876 id: cord-291624-fod0eyuj author: Malone, Robert W. title: COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms date: 2020-06-22 words: 6508 flesch: 35 summary: This modeling demonstrated that the different clinical outcomes exhibited by COVID-19 patients taking famotidine vs. cimetidine could be readily explained by the distinctive pharmacokinetic and pharmacodistribution properties of the two agents. It is towards the end of the rst week of symptoms that COVID-19 patients develop shortness of breath (SOB). keywords: activation; activity; cell; cimetidine; coronavirus; cov-2; covid-19; disease; famotidine; figure; histamine; infection; mast; patients; receptor; sars; symptoms; syndrome cache: cord-291624-fod0eyuj.txt plain text: cord-291624-fod0eyuj.txt item: #1492 of 2876 id: cord-291670-mqj071gp author: Raredon, M. S. B. title: Pressure-Regulated Ventilator Splitting (PReVentS): A COVID-19 Response Paradigm from Yale University date: 2020-04-06 words: 8503 flesch: 50 summary: Because ventilation with the PReVentS paradigm relies upon setting individual patient inspiratory pressures and expiratory pressures (similar to any pressure-controlled ventilation mode on a single patient ventilator), most adjustments should be familiar to the provider. â�¢ As the circuit is currently designed, negative circuit pressure near the patient will entrain room air through the negative-pressure relief valve -this will briefly decrease the FiO2 following in-line suctioning, or if the patient makes strong respiratory effort during the ventilator's expiratory phase. keywords: circuit; expiratory; license; lung; patient; peep; preprint; pressure; prevents; set; valve; ventilator cache: cord-291670-mqj071gp.txt plain text: cord-291670-mqj071gp.txt item: #1493 of 2876 id: cord-291686-kgewmqg5 author: Patel, Surendra title: Prioritizing cardiovascular surgical care in COVID‐19 pandemic: Shall we operate or defer? date: 2020-07-15 words: 1621 flesch: 39 summary: After reviewing a few available guidelines regarding cardiovascular surgery in COVID‐19, we conclude to perform only those surgeries which cannot be deferred to a certain period of time, to reduce the burden of the health care system of the country, provide optimal care to patients with COVID‐19, and to protect health care workers and cardiovascular patients from COVID‐19. Cardiovascular patients have a greater risk of acquiring COVID-19 infection, with morbidity and mortality much more in these patients in comparison to healthy individuals. keywords: covid-19; pandemic; patients; surgery cache: cord-291686-kgewmqg5.txt plain text: cord-291686-kgewmqg5.txt item: #1494 of 2876 id: cord-291687-kwu0otpi author: Judson, Gregory L. title: Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection date: 2020-06-13 words: 5583 flesch: 34 summary: The initial cohort study of COVID-19 patients included data from 552 hospitals in China with 1099 patients with COVID-19 disease [17] . Initial reports of myocarditis from China described cases of cardiogenic shock and reduced left ventricular ejection fraction among COVID-19 patients [37, 38] . keywords: acute; cardiac; china; coronavirus; cov-2; covid-19; disease; infection; injury; mortality; patients; sars cache: cord-291687-kwu0otpi.txt plain text: cord-291687-kwu0otpi.txt item: #1495 of 2876 id: cord-291697-wpnq9wc0 author: Riechelmann, Rachel P title: Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group date: 2020-05-22 words: 5873 flesch: 39 summary: A meta-analysis Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as firstline treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study Capecitabine and oxaliplatin for advanced esophagogastric cancer Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach A six-weekly (Q6W) dosing schedule for pembrolizumab based on an exposure-response (E-R) evaluation using modeling and simulation American College of Surgeons COVID-19: guidance for triage of non-emergent surgical procedures Staging investigations for oesophageal cancer: a meta-analysis Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a r Lancet Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial Optimal timing for postsurgical adjuvant therapy in patients with gastric cancer: a propensity score matching study Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer Cochrane database Syst Rev 8 CD010511 Pembrolizumab versus chemotherapy as second-line therapy for advanced esophageal cancer: phase III KEYNOTE-181 study Clinical Oncology COVID-19 Provider & Practice Information Centers for Disease Control and Prevention Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease Individual patient data meta-analysis of the value of microsatellite instability as a biomarker in gastric cancer PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and managemen Neoadjuvant herapy followed by resection versus upfront resection for resectable pancreatic cancer: a propensity score matched analysis Preoperative chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: results of the Dutch Randomized Phase III PREOPANC Total neoadjuvant therapy with FOLFIRINOX followed by individualized chemoradiotherapy for borderline resectable pancreatic adenocarcinoma: a phase 2 clinical trial FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine FOLFIRINOX until progression, FOLFIRINOX with maintenance treatment, or sequential treatment with gemcitabine and FOLFIRI.3 for first-line treatment of metastatic pancreatic cancer: a randomized phase II trial (PRODIGE 35-PANOPTIMOX) Randomized, multicenter, phase II rial of gemcitabine and cisplatin with or without veliparib in patients with pancreas adenocarcinoma and a germline BRCA/PALB2 mutation Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer American Association of Transplantation 2019-nCoV (Coronavirus): FAQs for Organ Donation and Transplantation Utility of positron emission tomography-computed tomography scan in detecting residual hepatocellular carcinoma post treatment: Series of case reports IMbrave150: a randomized phase III study of 1L atezolizumab plus bevacizumab vs sorafenib in locally advanced or metastatic hepatocellular carcinoma Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial Sorafenib in advanced hepatocellular carcinoma Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled Safety and efficacy of sorafenib in patients with Child-Pugh B advanced hepatocellular carcinoma Guidelines for the management of neuroendocrine tumours by the Brazilian gastrointestinal tumour group Ecancermedicalscience 11 716 Sunitinib malate for the treatment of pancreatic neuroendocrine tumors A randomized study of temozolomide or temozolomide and capecitabine in patients with advanced pancreatic neuroendocrine tumors: a trial of the ECOG-ACRIN Cancer Research Group (E2211) Opportunist and serious infections in patients with neuroendocrine tumours treated with everolimus: a multicenter study of real world patients International expert consensus statement regarding radiotherapy treatment options for rectal cancer during the COVID 19 pandemic Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial Randomized phase II trial of chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: CAO/ARO/AIO-12 Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study Total neoadjuvant therapy with short course radiation compared to concurrent chemoradiation in rectal cancer Achieving a complete clinical response after neoadjuvant chemoradiation that does not require surgical resection: it may take longer than you think! However, few data on the outcomes of cancer patients infected by SARS CoV-2 exist. keywords: cancer; chemotherapy; clinical; covid-19; disease; eor; metastatic; neoadjuvant; patients; phase; recommendations; surgery; treatment; tumours cache: cord-291697-wpnq9wc0.txt plain text: cord-291697-wpnq9wc0.txt item: #1496 of 2876 id: cord-291855-wtwz94sy author: Tambone, Vittoradolfo title: Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic date: 2020-06-16 words: 1150 flesch: 36 summary: It is therefore mandatory to explore alternative solutions; these include increasing available beds and healthcare providers, implementing alternative, though suboptimal, approaches (where appropriate), transferring patients to other clinical units, etc. Having applied standard clinical evaluation criteria for the appropriate treatment of patients with COVID-19, including consideration of prognosis, if a hospital then finds itself unable to provide optimal treatment (e.g., due to a disproportion between the number of patients and the availability of beds, healthcare providers, ventilators, and drugs in the ICU), it becomes necessary to evaluate, case by case, how to achieve justice and the best possible good for the greatest number of patients. keywords: criteria; good; patients; resources cache: cord-291855-wtwz94sy.txt plain text: cord-291855-wtwz94sy.txt item: #1497 of 2876 id: cord-291873-inzzywps author: Tognetto, Daniele title: Managing ophthalmic practices in a referral emergency COVID‐19 hospital in north‐east Italy date: 2020-06-01 words: 722 flesch: 41 summary: To diminish the risk of contamination, some healthcare facilities, included our hospital, were assigned as referral regional care centre for COVID-19 patients. For positive patients, a dedicated operating theatre with negative pressure laminar flow is provided. keywords: covid-19; patients; risk cache: cord-291873-inzzywps.txt plain text: cord-291873-inzzywps.txt item: #1498 of 2876 id: cord-292054-x0saq938 author: Hashizume, Misato title: Outlook of IL-6 signaling blockade for COVID-19 pneumonia date: 2020-10-05 words: 3801 flesch: 37 summary: In the USA, FDA declared the emergency use authorization for use of IL-6 immunoassay for COVID-19 patients [32] . Additionally, no new safety findings were observed with the use of sarilumab in COVID-19 patients [48] . keywords: cell; covid-19; il-6; patients; phase; pneumonia; study; tocilizumab; treatment cache: cord-292054-x0saq938.txt plain text: cord-292054-x0saq938.txt item: #1499 of 2876 id: cord-292056-dtdyxhq4 author: Ghogawala, Zoher title: Editorial. COVID-19 and spinal surgery date: 2020-04-17 words: 1396 flesch: 44 summary: As elective surgery has been reduced in hospitals, many spinal surgeons have been asked to participate in the care of medical patients. The mortality rates have been higher in Spain and Italy, and the numbers of infected patients have overwhelmed hospitals. keywords: covid-19; patients; spinal; surgeons; surgery cache: cord-292056-dtdyxhq4.txt plain text: cord-292056-dtdyxhq4.txt item: #1500 of 2876 id: cord-292094-vmsdhccp author: Mandell, Lionel A. title: Infectious Diseases Society of America/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults date: 2007-03-01 words: 28417 flesch: 34 summary: A statewide initiative to improve the care of hospitalized pneumonia patients: The Connecticut Pneumonia Pathway Project Implementation of an evidencebased guideline to reduce duration of intravenous antibiotic therapy and length of stay for patients hospitalized with community-acquired pneumonia: a randomized controlled trial Improving the quality of care for patients with pneumonia in very small hospitals Early mobilization of patients hospitalized with community-acquired pneumonia A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. For other patients with CAP, the recommendations for diagnostic testing focus on patients in whom the diagnostic yield is thought to be greatest. keywords: admission; adults; antibiotic; cap; care; community; criteria; culture; disease; evidence; factors; guidelines; hospital; icu; infection; influenza; level; management; mortality; pathogens; patients; pneumococcal; pneumonia; recommendation; resistance; respiratory; results; risk; sputum; studies; study; therapy; treatment; use cache: cord-292094-vmsdhccp.txt plain text: cord-292094-vmsdhccp.txt item: #1501 of 2876 id: cord-292315-7vwybku8 author: Jung, Gyuwon title: Too Much Information: Assessing Privacy Risks of Contact Trace Data Disclosure on People With COVID-19 in South Korea date: 2020-06-18 words: 7868 flesch: 47 summary: Front Public Health DOI: 10.3389/fpubh.2020.00305 sha: doc_id: 292315 cord_uid: 7vwybku8 Introduction: With the COVID-19 outbreak, South Korea has been making contact trace data public to help people self-check if they have been in contact with a person infected with the coronavirus. Despite its benefits in suppressing the spread of the virus, publicizing contact trace data raises concerns about individuals' privacy. keywords: cases; contact; data; disclosure; information; level; location; patient; places; privacy; risk; trace cache: cord-292315-7vwybku8.txt plain text: cord-292315-7vwybku8.txt item: #1502 of 2876 id: cord-292335-al6v3b9x author: Crotty, Matthew P. title: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date: 2015-11-18 words: 4446 flesch: 29 summary: Pandemic 2009 influenza A in Argentina: a study of 337 patients on mechanical ventilation Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness Critically ill infants and children with influenza A (H1N1) in pediatric intensive care units in Argentina Critically ill patients with 2009 influenza A (H1N1) infection in Canada Community acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A (H1N1) virus Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States Critical care services and 2009 H1N1 influenza in Australia and New Zealand Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1)-United States Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections Lung pathology in fatal novel human influenza A (H1N1)infection Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children Viral etiology of severe pneumonia among Kenyan infants and children Incidence of respiratory pathogens in persons hospitalized with pneumonia in two provinces in Thailand A preliminary study of pneumonia etiology among hospitalized children in Kenya Etiology of community-acquired pneumonia in hospitalized children in northern Taiwan Viral coinfections in children with invasive pneumococcal disease Temporal association between rhinovirus circulation in the community and invasive pneumococcal disease in children Clinical and molecular characterization of rhinoviruses A, B, and C in adult patients with pneumonia Infection with human metapneumovirus predisposes mice to severe pneumococcal pneumonia Viral enhancement of nasal colonization with Haemophilus influenzae type b in the infant rat Epidemiology and predictors of multidrug-resistant community-acquired and health care-associated pneumonia Pneumonia pathogen characterization is an independent determinant of hospital readmission Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients The effect of rapid respiratory viral diagnostic testing on antibiotic use in a children's hospital Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study Impact of rapid detection of viral and atypical bacterial pathogens by real-time polymerase chain reaction for patients with lower respiratory tract infection Antibiotic-resistant bugs in the 21st century: a clinical super-challenge A comparison of culture-positive and culture-negative health-care-associated pneumonia Epidemiological differences between sepsis syndrome with bacteremia and culture-negative sepsis Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance A new method of classifying prognostic comorbidity in longitudinal studies: development and validation Measurement of adult antibacterial drug use in 130 US hospitals: comparison of defined daily dose and days of therapy Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults Strategies to prevent antimicrobial resistance in the intensive care unit Burden of Clostridium difficile infection in the United States Clostridium difficile infection The use of antimicrobial agents after diagnosis of viral respiratory tract infections in hospitalized adults: antibiotics or anxiolytics The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 U.S. adult intensive care units The problem with cephalosporins Does antibiotic exposure increase the risk of methicillin-resistant Staphylococcus aureus (MRSA) isolation? key: cord-292335-al6v3b9x authors: Crotty, Matthew P.; Meyers, Shelby; Hampton, Nicholas; Bledsoe, Stephanie; Ritchie, David J.; Buller, Richard S.; Storch, Gregory A.; Kollef, Marin H.; Micek, Scott T. title: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship date: 2015-11-18 journal: Crit Care DOI: 10.1186/s13054-015-1120-5 sha: doc_id: 292335 cord_uid: al6v3b9x INTRODUCTION: keywords: antibacterials; course; days; infection; patients; pneumonia; study; therapy; virus cache: cord-292335-al6v3b9x.txt plain text: cord-292335-al6v3b9x.txt item: #1503 of 2876 id: cord-292345-zc209dfx author: Carroll, Elizabeth title: Catastrophic Intracranial Hemorrhage in Two Critically Ill Patients with COVID-19 date: 2020-05-26 words: 1583 flesch: 45 summary: However, brain autopsies from other patients with COVID-19 have reportedly demonstrated hyperemic and edematous parenchyma [2] . Although it has been noted that COVID-19 may increase risk for acute cerebrovascular events, including both ischemic and hemorrhagic stroke [2] , to our knowledge, this is the first report of patients with COVID-19 who had catastrophic intracranial hemorrhages. keywords: anticoagulation; covid-19; patients cache: cord-292345-zc209dfx.txt plain text: cord-292345-zc209dfx.txt item: #1504 of 2876 id: cord-292350-cmrtg91a author: Mondal, Samhati title: Thromboembolic disease in COVID-19 patients: A brief narrative review date: 2020-09-14 words: 4006 flesch: 20 summary: key: cord-292350-cmrtg91a authors: Mondal, Samhati; Quintili, Ashley L.; Karamchandani, Kunal; Bose, Somnath title: Thromboembolic disease in COVID-19 patients: A brief narrative review date: 2020-09-14 journal: J Intensive Care DOI: 10.1186/s40560-020-00483-y sha: doc_id: 292350 cord_uid: cmrtg91a Corona virus 2 (SARS-CoV2/ Severe Acute Respiratory Syndrome Corona Virus 2) infection has emerged as a global health crisis. Table 1 & 2 summarize the various thrombotic complications noted in COVID-19 patients as published as of June 6 th , 2020 obtained by a literature search on PubMed and EMBASE using combinations of the following MeSH terms: COVID-19, SARS-COV2, novel corona virus, thrombosis, thromboembolic complications, pulmonary embolism. keywords: acute; anticoagulation; complications; covid-19; disease; patients; pulmonary; risk; thrombosis; venous cache: cord-292350-cmrtg91a.txt plain text: cord-292350-cmrtg91a.txt item: #1505 of 2876 id: cord-292387-2xv3wgaq author: D′Agostino, Armando title: Brief Psychotic Disorder During the National Lockdown in Italy: An Emerging Clinical Phenomenon of the COVID-19 Pandemic date: 2020-08-06 words: 4566 flesch: 40 summary: 13 Suicidal behavior in ATPD/ BPD patients is quite common (36%-55%) and usually associated with mood instability and agitation. The absence of personality disorders or premorbid dysfunction in the history of BPD patients is typically reported [35] [36] [37] and reflects the characteristics of our patients. keywords: cases; covid-19; disorder; episode; lockdown; pandemic; patients; psychosis; symptoms cache: cord-292387-2xv3wgaq.txt plain text: cord-292387-2xv3wgaq.txt item: #1506 of 2876 id: cord-292394-91b3mm6c author: Ashish, A. title: Early CPAP reduced mortality in covid-19 patients. Audit results from Wrightington, Wigan and Leigh Teaching Hospitals NHS Foundation Trust. date: 2020-06-02 words: 1717 flesch: 51 summary: Patients given early CPAP and in particular within 48 hours of admission, are shown to have a better outcome (a significant probability of lower mortality) than patients who received late CPAP (more than 48 hours after admission). For this analysis we have employed a Binomial (logit) generalised mixed model (Pinheiro and Bates, 2000) , with patient outcome as response, and for the fixed effect the time of CPAP (continuous), squared Oxygen (continuous) and early CPAP (binary). keywords: covid-19; cpap; patients; use cache: cord-292394-91b3mm6c.txt plain text: cord-292394-91b3mm6c.txt item: #1507 of 2876 id: cord-292474-dmgd99d6 author: Berardi, Giammauro title: Continuing our work: transplant surgery and surgical oncology in a tertiary referral COVID-19 center date: 2020-06-04 words: 4612 flesch: 38 summary: As a further issue, it has already been shown that cancer patients are more susceptible to COVID-19 infections: 1% of COVID-19 patients in China had a history of cancer as compared to 0.29% among normal Chinese population [2] . Italy was one of the first western countries diagnosing COVID-19 patients in late January and was certainly the one suffering the most by the sudden outbreak of the disease. keywords: cancer; cases; covid-19; icu; outbreak; pandemic; patients; surgery; transplantations cache: cord-292474-dmgd99d6.txt plain text: cord-292474-dmgd99d6.txt item: #1508 of 2876 id: cord-292485-vk5xy3zn author: Prasad, Narayan title: The adverse effect of COVID pandemic on the care of patients with kidney diseases in India date: 2020-07-06 words: 3492 flesch: 48 summary: The total number of dialysis patients in these centres came down from 2517 to 2404. Despite these efforts, reports of dialysis patients suffering extreme adversity and even deaths were reported in the lay press. keywords: care; dialysis; hospitals; india; lockdown; patients; public; sector cache: cord-292485-vk5xy3zn.txt plain text: cord-292485-vk5xy3zn.txt item: #1509 of 2876 id: cord-292493-lx7zfgoi author: Firstenberg, Michael S. title: Isolation protocol for a COVID-2019 patient requiring emergent surgical intervention: case presentation date: 2020-04-19 words: 2355 flesch: 47 summary: The family did not visit him during his hospitalization due to the concern of COVID-2019 and subsequent anticipated need for self-quarantine, which is now hospital policy as well to not have visitors for suspect or confirmed COVID-2019 patients. Nevertheless, as the number of positive cases continue to growwith the associated morbidity and mortality, it is critical to control further spread via implementation and strict compliance with isolation precautions, as healthcare workers and other patients are at significant risk for exposure [2] . keywords: blood; covid-2019; icu; patient; room; team cache: cord-292493-lx7zfgoi.txt plain text: cord-292493-lx7zfgoi.txt item: #1510 of 2876 id: cord-292561-iy06b9h9 author: Miesbach, Wolfgang title: COVID-19: Coagulopathy, Risk of Thrombosis, and the Rationale for Anticoagulation date: 2020-07-17 words: 4900 flesch: 40 summary: These laboratory changes are consistent with previous studies which showed that hypoalbuminemia, lymphopenia, and C-reactive protein 4 mg/dL were the predictive factors for the progression of pneumonia to respiratory failure in MERS-CoV-infected patients and that elevated lactate dehydrogenase (LDH) levels were associated with hospital-acquired infection with SARS-CoV. 16 Similar to SARS and MERS, there is a link between inflammation and severe organ damage in COVID-19 patients. 32 Coagulopathy has been described in studies that document clinical and laboratory changes in COVID-19 patients in up to 50% of those with severe manifestations. keywords: acute; coagulopathy; covid-19; dimer; levels; patients; risk; sars; syndrome; thrombosis cache: cord-292561-iy06b9h9.txt plain text: cord-292561-iy06b9h9.txt item: #1511 of 2876 id: cord-292620-t8ocqm6g author: Somani, S. title: Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19 date: 2020-05-22 words: 2773 flesch: 43 summary: Finally, returning patients had shorter LOS on index hospitalization with notably a lower frequency of ICU care and inpatient anticoagulation. key: cord-292620-t8ocqm6g authors: Somani, S.; Richter, F.; Fuster, V.; De Freitas, J.; Naik, N.; Sigel, K.; Mount Sinai Covid Informatics Center,; Boettinger, E. P.; Levin, M. A.; Fayad, Z.; Just, A. C.; Charney, A.; Zhao, S.; Glicksberg, B. S.; Lala, A.; Nadkarni, G. title: Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19 date: 2020-05-22 journal: medRxiv : the preprint server for health sciences DOI: 10.1101/2020.05.17.20104604 sha: doc_id: keywords: covid-19; discharge; hospital; medrxiv; patients; preprint; return cache: cord-292620-t8ocqm6g.txt plain text: cord-292620-t8ocqm6g.txt item: #1512 of 2876 id: cord-292826-lus0tqmi author: Joseph, Tony title: Trauma care in a low-COVID pandemic environment: A new normal date: 2020-06-12 words: 1268 flesch: 37 summary: There will also need to be a re-evaluation of the way that trauma care is delivered with careful consideration of the indication for any trauma -related procedure from intubation to acute surgical care. The insidious nature of early COVID infection, compromised cognition and the unreliability of a subset of trauma patients all result in a significant proportion needing to be initially treated as if they were infected. keywords: care; pandemic; patients; trauma cache: cord-292826-lus0tqmi.txt plain text: cord-292826-lus0tqmi.txt item: #1513 of 2876 id: cord-292856-7hjzzxtm author: Viasus, Diego title: Influenza A(H1N1)pdm09-related pneumonia and other complications date: 2012-10-31 words: 4223 flesch: 27 summary: 8, 24 One study 27 found that 70% of patients with influenza A(H1N1)pdm09 virus infection and invasive group A Streptococcus died, compared with an overall mortality rate of 2-6% for hospitalized influenza A(H1N1)pdm09 patients in other studies. Community-acquired respiratory coinfection in critically ill patients with pandemic 2009 influenza A(H1N1) virus Pulmonary imaging of pandemic influenza H1N1 infection: relationship between clinical presentation and disease burden on chest radiography and CT During the herald wave of the pandemic bacterial pneumonia relatively rare with fatal swine influenza (H1N1) pneumonia: if chest films have no focal segmental/lobar infiltrates, antibiotic therapy is unnecessary A 1-year prospective study of the infectious etiology in patients hospitalized with acute exacerbations of COPD Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Children with asthma hospitalized with seasonal or pandemic influenza Clinical findings and demographic factors associated with intensive care unit admission in Utah due to 2009 novel influenza A (H1N1) infection Hospitalizations for pandemic (H1N1) 2009 among Maori and Pacific Islanders Surveillance of the first 205 confirmed hospitalised cases of pandemic H1N1 influenza in Ireland Factors associated with severe disease in hospitalized adults with pandemic (H1N1) 2009 in Spain Prognosis of 2009 A(H1N1) influenza in hospitalized pregnant women in a context of early diagnosis and antiviral therapy Clinical presentation and prognosis of the 2009 H1N1 influenza A infection in HIV-1-infected patients: a Spanish multicenter study Early use of glucocorticoids was a risk factor for critical disease and death from pH1N1 infection Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis Risk factors for hospitalization and severe outcomes of 2009 pandemic H1N1 influenza in Quebec Timing of oseltamivir administration and outcomes in hospitalized adults with pandemic 2009 influenza A(H1N1) virus infection The role of pneumonia scores in the emergency room in patients infected by 2009 H1N1 infection Severity assessment tools in ICU patients with 2009 Influenza A (H1N1) pneumonia Influenza as a trigger for acute myocardial infarction or death from cardiovascular disease: a systematic review Acute myocarditis mimicking acute myocardial infarction associated with pandemic 2009 (H1N1) influenza A virus Cardiac manifestations in patients with pandemic (H1N1) 2009 virus infection needing intensive care Electrocardiographic abnormalities in patients with novel H1N1 influenza virus infection Pediatric neurological complications of 2009 pandemic influenza A (H1N1) keywords: a(h1n1)pdm09; admission; bacterial; chronic; complications; disease; infection; influenza; pandemic; patients; pneumonia; virus cache: cord-292856-7hjzzxtm.txt plain text: cord-292856-7hjzzxtm.txt item: #1514 of 2876 id: cord-292952-z7ajsf2r author: Wong, Anselm title: COVID‐19 and toxicity from potential treatments: Panacea or poison date: 2020-05-12 words: 1426 flesch: 48 summary: Remdesivir has been used previously to treat Ebola and recently has been prescribed to a small cohort study of COVID-19 patients. This pandemic has proven to be a challenge given that there is no immediate cure, no vaccine is currently available and medications or treatments being used are still undergoing clinical trials. keywords: covid-19; hydroxychloroquine; overdose; patients cache: cord-292952-z7ajsf2r.txt plain text: cord-292952-z7ajsf2r.txt item: #1515 of 2876 id: cord-293086-6282sb6b author: Liddell, Kathleen title: Who gets the ventilator? Important legal rights in a pandemic date: 2020-05-11 words: 5506 flesch: 43 summary: They take the view that when Current controversy there are multiple critically ill patients, each with an equal ethical claim to be ventilated and not enough ventilators for all, doctors should prioritise patients who are more likely to recover swiftly (thereby clearing the ventilators for other patients in need). Approximately 2.5% of patients need mechanical ventilation while their body fights the infection. keywords: care; covid-19; doctors; law; nhs; patients; rights; treatment; triage; ventilator cache: cord-293086-6282sb6b.txt plain text: cord-293086-6282sb6b.txt item: #1516 of 2876 id: cord-293143-1k170shh author: Dieninghoff, Doris title: Fatal HBoV-1 infection in adult female cystic fibrosis patient date: 2016-07-18 words: 1752 flesch: 42 summary: Speculations on the importance of an episomal genomic form of human bocavirus Comparison of tissue distribution, persistence, and molecular epidemiology of parvovirus B19 and novel human parvoviruses PARV4 and human bocavirus Persistence of human bocavirus DNA in immunocompromised children The human bocavirus is associated with some lung and colorectal cancers and persists in solid tumors Bocavirus episome in infected human tissue contains non-identical termini Human bocavirus 1 infects commercially available primary human airway epithelium cultures productively Detection of head-to-tail DNA sequences of human bocavirus in clinical samples Latent infection of Human Bocavirus accompanied by flare of chronic cough, fatigue, and episodes of viral replication in an immunocompetent adult patient Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia Human bocavirus can be cultured in differentiated human airway epithelial cells Replication of an autonomous human parvovirus in non-dividing human airway epithelium is facilitated through the DNA damage and repair pathways In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia Development of cystic fibrosis and noncystic fibrosis airway cell lines Detection of HBoV DNA in idiopathic lung fibrosis Acute human bocavirus infection in MDS patient Case report: Human bocavirus associated pneumonia as cause of acute injury, Cologne Low copy number detection of HBoV DNA in BAL of asymptomatic adult patients Human bocavirus in an immunocompromised child presenting with severe diarrhea New molecular approaches in the diagnosis of acute diarrhea: The human bocavirus is associated with some lung and colorectal cancers and persists in solid tumors Screening of human bocavirus in surgically excised cancer specimens Human bocavirus 1 primary infection and shedding in infants Community surveillance of respiratory viruses among families in the Utah better identification of germs-longitudinal viral epidemiology (BIG-LoVE) study Respiratory infections with human bocavirus keywords: bocavirus; hbov; human; infection; patient cache: cord-293143-1k170shh.txt plain text: cord-293143-1k170shh.txt item: #1517 of 2876 id: cord-293167-3bd3adip author: Nepal, Gaurav title: Neurological manifestations of COVID-19: a systematic review date: 2020-07-13 words: 5554 flesch: 43 summary: Acute respiratory distress syndrome, acute heart injury or failure, acute kidney injury, sepsis, disseminated intravascular coagulation, and lifethreatening metabolic derangements have all been reported in COVID-19 patients, particularly among those with underlying comorbidities or advanced age In this systematic review, we evaluate various neurological manifestations reported in COVID-19 patients and hypothesize their underlying pathophysiology. keywords: acute; case; china; coronavirus; cov-2; covid-19; infection; manifestations; patients; sars; studies; study; symptoms cache: cord-293167-3bd3adip.txt plain text: cord-293167-3bd3adip.txt item: #1518 of 2876 id: cord-293180-f1ulk9ce author: Li, R W K title: Severe Acute Respiratory Syndrome (SARS) and the GDP. Part II: Implications for GDPs date: 2004-08-14 words: 4294 flesch: 46 summary: SARS patients are unlikely to seek dental treatment in the early acute phase of the disease owing to the rapid course of the disease and the onset of fever as a primary symptom. Exclusion from duty is recommended if symptoms develop during the 10 days following unprotected exposure to SARS patients (or visit to high-risk areas), and for 10 days after the resolution of symptoms. keywords: aerosol; air; contact; control; dental; disease; health; infection; patient; sars; use cache: cord-293180-f1ulk9ce.txt plain text: cord-293180-f1ulk9ce.txt item: #1519 of 2876 id: cord-293285-w8c3ma8l author: Lanza, F title: Reflection on passive immunotherapy in those who need most: some novel strategic arguments for obtaining safer therapeutic plasma or autologous antibodies from recovered COVID ‐19 infected patients date: 2020-05-14 words: 1507 flesch: 31 summary: All rights reserved convalescent plasma, obtainable by plasmapheresis of recovered COVID 19 attacks, who would be volunteering to donate plasma or immunoglobulin-containing fractions has been proposed and implemented with success in COVID 19 cases (Chen et al, 2020; Shen et al, 2020 ; WHO, 2020; Casadevall et al, 2020; Seghatchian et al, 2020) . Based on this consideration, it might be postulated that either the preventive or the therapeutic use of convalescent plasma may be beneficial in chemotherapy-treated cancer patients, possibly mitigating the impact of COVID-19 (Dholaria B, et al, 2020) . keywords: covid; patients; plasma cache: cord-293285-w8c3ma8l.txt plain text: cord-293285-w8c3ma8l.txt item: #1520 of 2876 id: cord-293333-mqoml9o5 author: Scharbarg, Emeric title: From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves date: 2020-10-03 words: 5786 flesch: 55 summary: The subsystem (2) will be strongly observable if and only if the matrix has full rank, which happens if and only if The different notions of observability are peculiar of time delay systems. Since the health status is far from being homogeneous over a full country and since the health system consists in a network of major regional hospitals, it is worth to take advantage of the availability and agility of local hospital data rather than just merging them in some centralized information system. keywords: covid-19; dynamics; hospital; model; number; patients; time cache: cord-293333-mqoml9o5.txt plain text: cord-293333-mqoml9o5.txt item: #1521 of 2876 id: cord-293472-d3iwlpsr author: Afilalo, Marc title: Evaluation and Management of Seasonal Influenza in the Emergency Department date: 2012-04-06 words: 9922 flesch: 31 summary: The epidemiology of influenza 1948-1953 Safety and efficacy of nebulized zanamivir in hospitalized patients with serious influenza Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial Oral oseltamivir treatment of influenza in children Viral shedding in children with influenza virus infections treated with neuraminidase inhibitors Duration of influenza A virus shedding in hospitalized patients and implications for infection control Viral loads and duration of viral shedding in adult patients hospitalized with influenza Prolonged shedding of amantadineresistant influenzae A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis Common emergence of amantadineand rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults Prolonged excretion of amantadine-resistant influenza A virus quasi species after cessation of antiviral therapy in an immunocompromised patient Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy Prolonged shedding of multidrugresistant influenza A virus in an immunocompromised patient The effects of influenza virus infection on FEV1 in asthmatic children. Public Health Agency of Canada APPENDIX 1: REFERENCES FOR TABLE 4 Manufacturer's product information or product insert Comparison of Binax NOW and Directigen for rapid detection of influenza A and B Evaluation of three immunoassay kits for rapid detection of influenza A and B Comparison of rapid diagnostic techniques for respiratory syncytial virus and influenza A virus respiratory infections in young children Comparison of a new neuraminidase detection assay with an enzyme immunoassay, immunofluorescence, and culture for rapid detection of influenza A and B viruses in nasal wash specimens Application of Directigen FLU-A for the detection of influenza A virus in human and nonhuman specimens Comparison of Directigen FLU-A with viral isolation and direct immunofluorescence for the rapid detection and identification of influenza A virus Comparison of rapid detection methods for influenza A and their value in health care management of institutionalized geriatric patients Evaluation of a rapid enzyme immunoassay for detection of influenza A virus Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus Evaluation of the Directigen FluA1B test for rapid diagnosis of influenza virus type A and B infections Clinical evaluation of the ZstatFlu-II test: a chemiluminescence rapid diagnostic test for influenza virus Comparison of the Directigen Flu A1B test, the QuickVue Influenza test, and clinical case definition to viral culture and reverse transcription-PCR for rapid diagnosis of influenza virus infection Comparison of lateral-flow immunoassay and enzyme immunoassay with viral culture for rapid detection of influenza virus in nasal wash specimens from children Comparison of the Denka Seiken INFLU A-B Quick and BD Directigen Flu A1B kits with fluorescent-antibody staining and shell vial culture methods for rapid detection of influenza viruses Suboptimal detection of influenza virus in adults by the Directigen Flu A1B enzyme immunoassay and correlation of results with the number of antigen-positive cells detected by cytospin immunofluorescence Comparison of four clinical specimen types for detection of influenza A and B viruses by optical immunoassay (FLU OIA test) and cell culture methods Evaluation of a rapid optical immunoassay for influenza viruses (FLU OIA test) in comparison with cell culture and reverse transcription-PCR Evaluation of Biostar FLU OIA assay for rapid detection of influenza A and B viruses in respiratory specimens Evaluation of an optical immunoassay for the rapid detection of influenza A and B viral antigens A flu optical immunoassay (ThermoBioStar's FLU OIA): a diagnostic tool for improved influenza management Simultaneous detection and typing of influenza viruses A and B by a nested reverse transcription-PCR: comparison to virus isolation and antigen detection by immunofluorescence and optical immunoassay (FLU OIA) Evaluation of diagnostic tests for influenza in a pediatric practice Evaluation of a rapid test (QuickVue) compared with the shell vial assay for detection of influenza virus clearance after antiviral treatment Influenza virological surveillance in children: the use of the QuickVue rapid diagnostic test QuickVue influenza test for rapid detection of influenza A and B viruses in a pediatric population Clinical evaluation of an immunochromatography test for rapid diagnosis of influenza Evaluation of immunochromatography method for rapid detection of influenza A and B viruses Evaluation of new rapid influenza virus detection kit-QUICK S-INFLU A/B SEIKEN Comparison of a new lateral-flow chromatographic membrane immunoassay to viral culture for rapid detection and differentiation of influenza A and B viruses in respiratory specimens Evaluation of a neuraminidase detection assay for the rapid detection of influenza A and B virus in children New point of care test is highly specific but less sensitive for influenza A and B in children and adults Evaluation of an immunochromatography test using enzyme immunoassay for rapid detection influenza A and B viruses Comparison of three rapid diagnostic kits using immunochromatography for detection of influenza A viruses Evaluation of an immunochromatography test kit for rapid diagnosis of influenza Evaluation of flow-through immunoassay for rapid detection of influenza A and B viruses keywords: care; children; detection; health; hours; illness; infection; influenza; influenza virus; onset; patients; persons; symptoms; test; treatment; virus; viruses cache: cord-293472-d3iwlpsr.txt plain text: cord-293472-d3iwlpsr.txt item: #1522 of 2876 id: cord-293522-gg706q8s author: Toumi, Mondher title: Commentary on “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial” by Gautret et al date: 2020-05-13 words: 5239 flesch: 48 summary: The patients who refused to receive hydroxychloroquine were used as control patients, as were noneligible patients. [21] , we could assess the proportion of patients who were negative at 65% for hydroxychloroquine arm compared with 12.5% for the control arm, which is still statistically significant (p = 0.0012) and very clinically relevant. keywords: clinical; control; coronavirus; covid-19; health; hydroxychloroquine; patients; results; study; treatment cache: cord-293522-gg706q8s.txt plain text: cord-293522-gg706q8s.txt item: #1523 of 2876 id: cord-293547-29i3u83s author: Pfaar, O title: COVID‐19 pandemic: Practical considerations on the organization of an allergy clinic – an EAACI/ARIA Position Paper date: 2020-06-12 words: 8815 flesch: 37 summary: Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Coronavirus disease (COVID-2019) situation reports Asthma and Allergy Foundation of America (aafa) Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Coronavirus disease (COVID-19) technical guidance: Patient management Eleven faces of coronavirus disease 2019 Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI statement Treatment of chronic RhinoSinusitis with nasal polyps (CRSwNP) in the COVID-19 pandemic -An EAACI Position Paper Is diet partly responsible for differences in COVID-19 death rates between and within countries? ARIA-EAACI statement on Asthma and COVID-19 COVID-19 in a designated infectious diseases hospital outside Hubei Province Distinct characteristics of COVID-19 patients with initial rRT-PCR-positive and rRT-PCR-negative results for SARS-CoV-2 Advanced forecasting of SARS-CoV-2-related deaths in Italy Is global BCG vaccination-induced trained immunity relevant to the progression of SARS-CoV-2 pandemic? Chronic rhinosinusitis (CRS) affects approximately 5-12% of the general population worldwide and is regarded as a chronic airway disease, that, according to WHO recommendations, may be a risk factor for COVID-19 patients keywords: allergy; article; asthma; care; case; clinic; copyright; cov-2; covid-19; disease; eaaci; health; infection; pandemic; patients; rights; risk; sars; symptoms; treatment cache: cord-293547-29i3u83s.txt plain text: cord-293547-29i3u83s.txt item: #1524 of 2876 id: cord-293570-gh6ykmea author: Gupta, Rajib K. title: Spectrum of podocytopathies in new-onset nephrotic syndrome following COVID-19 disease: a report of 2 cases date: 2020-08-04 words: 3489 flesch: 47 summary: While all published case reports describe CG as the glomerular pathology, we describe a non-CG pathology (MCD) in one of our cases, thereby adding to the repertoire of renal pathology described in association with COVID-19 patients. Our case report describes a rare presenting complaint of COVID-19 patients with kidney involvementthat of new-onset nephrotic syndrome. keywords: biopsy; case; covid-19; disease; patients; podocyte; renal cache: cord-293570-gh6ykmea.txt plain text: cord-293570-gh6ykmea.txt item: #1525 of 2876 id: cord-293575-h3wc7j4v author: Adrish, Muhammad title: Association of smoking status with outcomes in hospitalised patients with COVID-19 date: 2020-10-05 words: 2661 flesch: 50 summary: Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research. key: cord-293575-h3wc7j4v authors: Adrish, Muhammad; Chilimuri, Sridhar; Mantri, Nikhitha; Sun, Haozhe; Zahid, Maleeha; Gongati, Sudharsan; Fortuzi, Ked; Jog, Abhishrut Pramod; Purmessur, Pravish; Singhal, Ravish title: Association of smoking status with outcomes in hospitalised patients with COVID-19 date: 2020-10-05 journal: BMJ Open Respir Res DOI: 10.1136/bmjresp-2020-000716 sha: doc_id: 293575 cord_uid: h3wc7j4v INTRODUCTION: keywords: covid-19; disease; illness; patients; smokers; smoking; study cache: cord-293575-h3wc7j4v.txt plain text: cord-293575-h3wc7j4v.txt item: #1526 of 2876 id: cord-293634-4rryqbnu author: Rosen, Kelsey title: Delivering Telerehabilitation to COVID-19 Inpatients:A Retrospective Chart Review Suggests It Is a Viable Option date: 2020-07-16 words: 3593 flesch: 30 summary: Patients assessed via telerehabilitation were provided individualized therapeutic exercises based on early anecdotal reports of high fatigability in patients with COVID-19 and clinical knowledge of therapeutic interventions for similar disease processes such as acute respiratory distress syndrome [3, 14, 15, 23] . The purpose of the inpatient telerehabilitation PT program for COVID-19 patients was to safely assess barriers to discharge, deliver patient education, and provide a home exercise program (HEP) all while minimizing staff exposure. keywords: covid-19; discharge; home; inpatient; patients; program; telerehabilitation; therapists cache: cord-293634-4rryqbnu.txt plain text: cord-293634-4rryqbnu.txt item: #1527 of 2876 id: cord-293704-tnik6sd3 author: Tey, Jeremy title: Navigating the challenges of the COVID-19 outbreak: perspectives from the radiation oncology service in singapore date: 2020-03-31 words: 3514 flesch: 48 summary: It highlights the challenges that radiation oncology departments in Singapore face and the appropriate recommended responses. It highlights the challenges that radiation oncology departments in Singapore face and the appropriate recommended responses. keywords: covid-19; oncology; outbreak; patients; radiation; radiotherapy; singapore; staff; treatment cache: cord-293704-tnik6sd3.txt plain text: cord-293704-tnik6sd3.txt item: #1528 of 2876 id: cord-293730-dlqo6fep author: Caratozzolo, Salvatore title: The impact of COVID-19 on health status of home-dwelling elderly patients with dementia in East Lombardy, Italy: results from COVIDEM network date: 2020-09-12 words: 3730 flesch: 42 summary: Influenza Other Respir Viruses Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 Pneumonia in Wuhan, China Characteristics and outcomes of patients hospitalized for COVID-19 and cardiac disease in Northern Italy Clinical characteristics of coronavirus disease 2019 in China Hypertension and COVID-19 Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19 Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension Italy: Non COVID-19 and COVID-19 patients differed for frequency of diabetes (18.5% vs. 37.9%, p < 0.001), COPD (7.3% vs. 18.9%, p < 0.001), and previous flu vaccination (56.7% vs. 37.9%, p < 0.001). keywords: covid-19; dementia; disease; health; home; patients; psy; study; symptoms cache: cord-293730-dlqo6fep.txt plain text: cord-293730-dlqo6fep.txt item: #1529 of 2876 id: cord-293740-4c3yemi3 author: Ferrando, Carlos title: Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS date: 2020-07-29 words: 4340 flesch: 50 summary: We examined the clinical features, ventilatory management, and clinical outcomes of COVID-19 ARDS patients, and compared some results with other relevant studies in non-COVID-19 ARDS patients. Our findings in a cohort of over 700 patients are in line with preliminary studies of COVID-19 ARDS patients [23, 24] . keywords: ards; covid-19; day; lung; non; patients; pressure; studies; study cache: cord-293740-4c3yemi3.txt plain text: cord-293740-4c3yemi3.txt item: #1530 of 2876 id: cord-293852-r72c6584 author: Greco, S. title: Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era date: 2020-10-31 words: 8171 flesch: 32 summary: However, in the heart of both SARS-CoV infected mice and of SARS patients, decreased ACE2-levels were observed [64] , suggesting a complex virus/receptor dynamic that needs to be elucidated. Interestingly, in the hearts of both SARS-CoV infected mice and SARS patients, macrophage infiltration with evidence of myocardial damage was observed [64] . keywords: ace2; cardiac; cardiovascular; cells; coronavirus; cov-2; covid-19; disease; expression; heart; human; infection; noncoding; patients; response; rna; rnas; sars cache: cord-293852-r72c6584.txt plain text: cord-293852-r72c6584.txt item: #1531 of 2876 id: cord-293922-knzv4jvj author: Zuo, Y. title: Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients date: 2020-09-02 words: 3051 flesch: 44 summary: A recent study of hospitalized COVID-19 patients also detected elevations of both PAI-1 and tPA, particularly among critically-ill COVID-19 patients [23] ; however, the mechanistic role of the elevated tPA among COVID-19 patients was not specifically investigated [23] . It has been suggested that high PAI-1 levels overcome the effects of local tPA and produce a net prothrombotic hypofibrinolytic state in COVID-19 patients [23] . keywords: covid-19; fibrinolysis; levels; medrxiv; patients; preprint; tpa cache: cord-293922-knzv4jvj.txt plain text: cord-293922-knzv4jvj.txt item: #1532 of 2876 id: cord-293964-hz5uow2b author: Hermann, Matthias title: Feasibility and Efficacy of Cardiopulmonary Rehabilitation following COVID-19 date: 2020-07-22 words: 2747 flesch: 45 summary: [8] [9] [10] However, as the whole COVID-19 condition is so new, there are scarce data available about feasibility, safety and success of in-patient CR in COVID-19 patients. Therefore, we retrospectively analyzed a cohort of COVID-19 patients in a single center inpatient rehabilitation clinic and describe performance and outcome during CR. keywords: covid-19; days; health; patients; rehabilitation; ventilation cache: cord-293964-hz5uow2b.txt plain text: cord-293964-hz5uow2b.txt item: #1533 of 2876 id: cord-294057-fbox3a5q author: Schlegl, Sandra title: Bulimia nervosa in times of the COVID‐19 pandemic—Results from an online survey of former inpatients date: 2020-08-07 words: 2819 flesch: 44 summary: The COVID‐19 pandemic might pose special challenges to patients with eating disorders (EDs) by interfering with daily routines. The aim of this study was to investigate the impact of the current pandemic on patients with bulimia nervosa (BN). keywords: covid-19; eating; pandemic; patients cache: cord-294057-fbox3a5q.txt plain text: cord-294057-fbox3a5q.txt item: #1534 of 2876 id: cord-294064-vdpak3fm author: Iqbal, Muhammad Rafaih title: Single centre concept of ‘cold site’ elective surgery during the peak of COVID-19 pandemic: A cohort study date: 2020-10-06 words: 3039 flesch: 56 summary: 19.56% (63/322) of the patients were deemed unfit for CS elective surgery (Figure 2 ). As these systems got overwhelmed with the emergency care of the infected patients, widespread cancellations of elective surgery occurred. keywords: covid-19; pandemic; patients; study; surgery cache: cord-294064-vdpak3fm.txt plain text: cord-294064-vdpak3fm.txt item: #1535 of 2876 id: cord-294073-65h2mkdy author: Ke, Jia title: Strategies and recommendations for the management of gastrointestinal surgery during the COVID-19 pandemic: experience shared by Chinese surgeons date: 2020-07-03 words: 4156 flesch: 35 summary: Most importantly, the task force should have overall control regarding the balance between the resources being used for COVID-19 patients (e.g. personal protection equipment [PPE] , ventilators, intensive care unit [ICU] beds, physicians) and those that would be used for surgical patients. Clinical characteristics of coronavirus disease 2019 in China Detection of SARS-CoV-2 in different types of clinical specimens Evidence for gastrointestinal infection of SARS-CoV-2 Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study A multidisciplinary team approach for triage of elective cancer surgery at the Massachusetts General Hospital during the novel coronavirus COVID-19 Outbreak Recommendations for general surgery clinical practice in novel coronavirus pneumonia situation Implications of COVID-19 for patients with pre-existing digestive diseases Advice for Endoscopy Teams during COVID-19 COVID-19 outbreak and surgical practice: unexpected fatality in perioperative period Characterization of smoke generated during the use of surgical knife in laparotomy surgeries COVID-19: Guidance for Triage of Non-Emergent Surgical Procedures. keywords: cancer; covid-19; patients; precautions; procedures; risk; sars; surgery cache: cord-294073-65h2mkdy.txt plain text: cord-294073-65h2mkdy.txt item: #1536 of 2876 id: cord-294079-px9c20il author: Chua, Horng-Ruey title: Ensuring Sustainability of Continuous Kidney Replacement Therapy in the Face of Extraordinary Demand: Lessons From the COVID-19 Pandemic date: 2020-06-04 words: 3930 flesch: 32 summary: The pandemic has placed unprecedented demands on the supply of CKRT machines and consumables, which is worsened by the global lockdown and disrupted supply chains. We have diversified our sources of CKRT machines from multiple vendors to ensure a continuity of supply. keywords: acute; catheter; citrate; ckrt; covid-19; filter; fluids; kidney; patients; replacement; therapy cache: cord-294079-px9c20il.txt plain text: cord-294079-px9c20il.txt item: #1537 of 2876 id: cord-294108-uvnh0s9r author: Dube, Taru title: Repurposed Drugs, Molecular Vaccines, Immune‐Modulators, and Nanotherapeutics to Treat and Prevent COVID‐19 Associated with SARS‐CoV‐2, a Deadly Nanovector date: 2020-10-25 words: 13897 flesch: 38 summary: COVID-19 patients seeking intensive care unit (ICU) are particularly older and more likely to carry pre-existing comorbid conditions like hypertension and related heart diseases followed by diabetes. To date, apart from the emergency use approval of the antiviral drug favilavir in China, India, Russia, and parts of the Middle East and the emergency use approval of remdesivir by the US-FDA and Japan in COVID-19 patients, there are no approved therapeutic molecules to treat the COVID-19 pandemic. keywords: care; cells; cov-2; covid-19; covid-19 patients; disease; dose; drug; efficacy; host; human; iii; infection; patients; phase; potential; protein; response; rna; safety; sars; therapeutics; treatment; trial; use; vaccine; virus cache: cord-294108-uvnh0s9r.txt plain text: cord-294108-uvnh0s9r.txt item: #1538 of 2876 id: cord-294139-78c5h7la author: Yamakawa, Mai title: Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis date: 2020-08-29 words: 3100 flesch: 38 summary: Forest plots for characteristics of stroke patients with COVID-19 (random-effects model); (A): The frequency of stroke Days from COVID-19 symptom onset to stroke; (C): D-dimer; (D): Case fatality rate Funding: None. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. keywords: case; covid-19; patients; risk; stroke; studies; study cache: cord-294139-78c5h7la.txt plain text: cord-294139-78c5h7la.txt item: #1539 of 2876 id: cord-294184-jte9xx5e author: Macleod, Jack title: Surgery during COVID-19 crisis conditions: can we protect our ethical integrity against the odds? date: 2020-06-12 words: 2749 flesch: 44 summary: Good Practice for Surgeons and Surgical Teams -Royal College of Surgeons Clinical guide for the management of cardiothoracic surgery patients during the Coronavirus pandemic Coronary artery bypass grafting vs. percutaneous coronary intervention for patients with three-vessel disease: final fiveyear follow-up of the SYNTAX trial Clinical outcomes with percutaneous coronary revascularization vs coronary artery bypass grafting surgery in patients with unprotected left main coronary artery disease: a meta-analysis of 6 randomized trials and 4,686 patients Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial The heart score for the assessment of patients with chest pain in the emergency department: a multinational validation study Principles of biomedical ethics The right and the good Origin and uses of primum non nocere--above all, do no harm! The lack of clear guidance lead to discussion in regards to how we treat urgent cardiac surgery patients to the best of our department's ability. keywords: covid-19; patients; principles; risk; standard; surgery cache: cord-294184-jte9xx5e.txt plain text: cord-294184-jte9xx5e.txt item: #1540 of 2876 id: cord-294270-do6i6ymq author: Banu, Buyukaydin title: Pneumonia date: 2019-11-29 words: 7323 flesch: 32 summary: The mechanisms that increase the incidence and mortality rates in elderly pneumonia patients are not fully understood. Mortality in elderly patients may be 25% higher than in the general population (10%). keywords: age; cap; cases; community; infection; mortality; pathogens; patients; pneumonia; risk; therapy; treatment; years cache: cord-294270-do6i6ymq.txt plain text: cord-294270-do6i6ymq.txt item: #1541 of 2876 id: cord-294294-66udu5y4 author: Bullock, Travis S. title: Outpatient surgery in patients with ankle fractures minimises hospital admissions and utilisation of healthcare resources date: 2020-08-08 words: 3199 flesch: 37 summary: Therefore, future studies will have to identify specific criteria that will allow for identifying which specific subset of patients is amenable to outpatient ankle fracture surgery. key: cord-294294-66udu5y4 authors: Bullock, Travis S.; Gutierrez-Naranjo, Jose M.; DelBello, Robert G.; Karia, Ravi A.; Zelle, Boris A. title: Outpatient surgery in patients with ankle fractures minimises hospital admissions and utilisation of healthcare resources date: 2020-08-08 journal: Int Orthop DOI: 10.1007/s00264-020-04768-7 sha: doc_id: 294294 cord_uid: 66udu5y4 PURPOSE: keywords: ankle; days; fractures; hospital; outpatient; patients; study; surgery cache: cord-294294-66udu5y4.txt plain text: cord-294294-66udu5y4.txt item: #1542 of 2876 id: cord-294336-fqobpo47 author: Soy, Mehmet title: Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic date: 2020-06-25 words: 5795 flesch: 36 summary: On the other hand, unlike primary HLH patients, observed differences in the pattern of T lymphocyte activation and differentiation in sHLH patients may imply differences in the pathogenesis of these two conditions. Numerous serum proinflammatory cytokine levels, including IL-1, IL-2, IL-6, IL-12, IL-16, IL-18, TNF-, and IFN-γ, were found to be significantly high in HLH patients sera. keywords: activation; covid-19; cytokine; diagnosis; hlh; lymphohistiocytosis; macrophage; mas; patients; phlh; syndrome; treatment cache: cord-294336-fqobpo47.txt plain text: cord-294336-fqobpo47.txt item: #1543 of 2876 id: cord-294349-ps3qlho2 author: Al-Sharif, Eman title: Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye date: 2020-09-03 words: 7059 flesch: 40 summary: In a previous case-control study conducted in China among healthcare providers who were taking care of SARS patients, all the 69 providers adhering to the four infection control measures (gown, gloves, mask and hand hygiene practices) did not contract the infection, while all the 13 infected staff omitted at least one of the four control measures [65] . In terms of ocular manifestations, a study published by Wu and colleagues on ocular findings in COVID-19 patients showed that approximately one-third of patients (12/38, 31.6%) had eye manifestations such as conjunctival redness, chemosis, tearing and increased secretions. keywords: conjunctival; coronavirus; cov-2; covid-19; disease; eye; human; infection; mers; patients; sars; studies; symptoms; transmission cache: cord-294349-ps3qlho2.txt plain text: cord-294349-ps3qlho2.txt item: #1544 of 2876 id: cord-294371-xot2oj2t author: Citgez, Bulent title: Management of Breast Cancer during the COVID-19 Pandemic date: 2020-06-10 words: 2226 flesch: 43 summary: In this review, we tried to explain how to prevent the negative effects of the COVID-19 pandemic on the diagnosis and treatment of breast cancer patients. Medications in breast cancer patients receiving NAC can suppress the development of a fever or other symptoms, and COVID-19 disease may remain asymptomatic until they develop sepsis. keywords: breast; cancer; covid-19; pandemic; patients; treatment cache: cord-294371-xot2oj2t.txt plain text: cord-294371-xot2oj2t.txt item: #1545 of 2876 id: cord-294443-w6p3f5qc author: Nadar, Sunil K. title: Managing hypertension during the COVID-19 pandemic date: 2020-05-14 words: 1644 flesch: 40 summary: The vasoprotective axes of the reninangiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases Clinical implications of SARS-Cov2 interaction with renin angiotensin system A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury Effects of ACE-inhibitors and angiotensin receptor blockers on inflammation European society of Hypertension statement Heart failure society of America joint statement Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin ii receptor blockers with mortality among patients with hypertension hospitalized with COVID-19 Reninangiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Hypertension and the prothrombotic state Indeed, hospitals have reported a decrease in the number of patients attending emergency departments with myocardial infarctions and cerebrovascular accidents [1, 2] . keywords: ace; covid-19; hypertension; inhibitors; patients cache: cord-294443-w6p3f5qc.txt plain text: cord-294443-w6p3f5qc.txt item: #1546 of 2876 id: cord-294487-hcuzxhb3 author: Shenoi, Susan title: Telemedicine in pediatric rheumatology: this is the time for the community to embrace a new way of clinical practice date: 2020-10-31 words: 2104 flesch: 33 summary: A proposed variation of the validated pediatric gait arms legs spine examination (pGALS) called the video pGALS (VpGALS) as a means of conducting virtual pediatric rheumatology physical examination is presented. This may include an in person telepresenter, multiple virtual support staff to help coordinate after visit care, and, other specialists and members of the multidisciplinary team (MDT). keywords: care; examination; patient; rheumatology; telemedicine; video; visits cache: cord-294487-hcuzxhb3.txt plain text: cord-294487-hcuzxhb3.txt item: #1547 of 2876 id: cord-294527-fct2y5vn author: Guadarrama-Ortiz, Parménides title: Neurological Aspects of SARS-CoV-2 Infection: Mechanisms and Manifestations date: 2020-09-04 words: 8837 flesch: 29 summary: (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Multiple organ infection and the pathogenesis of SARS Pathological study of the 2019 novel coronavirus disease. In this regard, there is increasing preoccupation with the neuroinvasive potential of SARS-CoV-2 due to the observation of neurological manifestations in COVID-19 patients. keywords: acute; barré; cells; clinical; coronavirus; cov-2; covid-19; disease; guillain; human; immune; individuals; infection; manifestations; patients; sars; symptoms; syndrome cache: cord-294527-fct2y5vn.txt plain text: cord-294527-fct2y5vn.txt item: #1548 of 2876 id: cord-294557-4h0sybiy author: Stogiannos, N. title: Coronavirus disease 2019 (COVID-19) in the radiology department: What radiographers need to know date: 2020-06-04 words: 6731 flesch: 41 summary: A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship with D-Dimer levels Clinical and CT features in pediatric patients with COVID-19 infection: different points of adults CT features of novel coronavirus pneumonia (COVID-19) in children Differences in clinical and imaging presentation of pediatric patients with COVID-19 in comparison to adults Clinical and CT imaging features of the COVID-19 pneumonia: focus on pregnant women and children Medical Imaging plays an important auxiliary role in the diagnosis of Covid-19 patients, mainly those most seriously affected. keywords: chest; coronavirus; covid-19; diagnosis; disease; findings; imaging; infection; management; patients; role cache: cord-294557-4h0sybiy.txt plain text: cord-294557-4h0sybiy.txt item: #1549 of 2876 id: cord-294593-mh1uh1b3 author: Boloori, Alireza title: Misalignment of Stakeholder Incentives in the Opioid Crisis date: 2020-10-16 words: 6459 flesch: 31 summary: A cost-standardized enhanced recovery pathway for mastectomy decreases length of stay Evaluation of the fentanyl patch-for-patch program in Ontario Implementation of a pharmacy consult to reduce co-prescribing of opioids and benzodiazepines in a veteran population Quality measures to reduce opioid use after common soft tissue hand and wrist procedures Evaluation of machine-learning algorithms for predicting opioid overdose risk among medicare beneficiaries with opioid prescriptions The effect of a federal controlled substance act schedule change on hydrocodone combination products claims in a Medicaid population State legal restrictions and prescription-opioid use among disabled adults Goals of chronic pain management: Do patients and primary care physicians agree and does it matter? Patient-clinician communication about pain: A conceptual model and narrative review Methadone and buprenorphine for the management of opioid dependence: A systematic review and economic evaluation Exploring the concepts of abstinence and recovery through the experiences of long-term opiate substitution clients An observation of lower rates of drug use over time in community syringe exchangers Integrating screening, brief intervention, and referral to treatment (SBIRT) into clinical practice settings: A brief review Use of drug treatment services among adults with opioid use disorder: Rates, patterns, and correlates Integrating buprenorphine treatment into office-based practice: A qualitative study Policy pathways to address provider workforce barriers to buprenorphine treatment How Much Does Opioid Treatment Cost Risk factors for discontinuation of buprenorphine treatment for opioid use disorders in a multi-state sample of Medicaid enrollees Characteristics and prescribing practices of clinicians recently waivered to prescribe buprenorphine for the treatment of opioid use disorder Motivations for non-prescribed buprenorphine use in a time of treatment expansion The role of patient payment method in premature discharge from methadone maintenance treatment Acceptability of naloxone dispensing among pharmacists Gohns, A. Barriers to, and incentives for, the transfer of opioid-dependent people on methadone maintenance treatment from secondary care to primary health care Hospital nurses' attitudes toward patients with a history of illicit drug use Empowerment and pathologization: A case study in Norwegian mental health and substance abuse services Assessing service and treatment needs and barriers of youth who use illicit and non-medical prescription drugs in Northern Ontario Adoption of evidence-based clinical innovations: The case of buprenorphine use by opioid treatment programs Delivering opioid maintenance treatment in rural and remote settings Addressing Workforce Needs for Medication Treatment of Opioid Use Disorder Expanding the Use of Medications to Treat Individuals with Substance Use Disorders Federal Resources for Rural Communities to Help Address Substance Use Disorder and Opioid Misuse CVS Health Expands Efforts to Educate Patients about Naloxone Implementation of the hub and spoke model for opioid use disorders in California: Rationale, design and anticipated impact Participation in a hospital incentive program for follow-up treatment for opioid use disorder Help is on the way: Medicare coverage of opioid treatment programs Effects of global payment and accountable care on medication treatment for alcohol and opioid use disorders Behavioral contingencies improve counseling attendance in an adaptive treatment model Comparing adaptive stepped care and monetary-based voucher interventions for opioid dependence Effects of lower-cost incentives on stimulant abstinence in methadone maintenance treatment: A National Drug Abuse Treatment Clinical Trials Network study The cost-effectiveness of prize-based and voucher-based contingency management in a population of cocaine-or opioid-dependent outpatients Community opioid treatment perspectives on contingency management: Perceived feasibility, effectiveness, and transportability of social and financial incentives Adding an internet-delivered treatment to an efficacious treatment package for opioid dependence Effects of incentives for naltrexone adherence on opiate abstinence in heroin-dependent adults A financial incentive program to improve appointment attendance at a safety-net hospital-based primary care hepatitis C treatment program Effects of time-based administration of abstinence reinforcement targeting opiate and cocaine use I's on the prize: A systematic review of individual differences in Contingency Management treatment response Application of a discrete choice experiment approach to support the design of a hepatitis C testing service in primary care Acceptability and willingness to pay for contingency management interventions among parents of young adults with problematic opioid use Factors contributing to the rise of buprenorphine misuse Diversion of methadone and buprenorphine from opioid substitution treatment: Patients who regularly sell or share their medication Contingency management in cocaine abusers: A dose-effect comparison of goods-based versus cash-based incentives Counselor attitudes toward the use of motivational incentives in addiction treatment Improving substance abuse treatment enrollment in community syringe exchangers Improving treatment enrollment and re-enrollment rates of syringe exchangers: 12-month outcomes A mobile technology platform integrating motivational coaching, adherence monitoring, and electronic pill dispensing for enhancing buprenorphine/naloxone adherence during opioid use disorder treatment: A pilot study Acceptability and feasibility of a mobile health application for video directly observed therapy of buprenorphine for opioid use disorders in an office-based setting Development of an integrated digital health intervention to promote engagement in and adherence to medication for opioid use disorder Health status of employed and unemployed methadone patients Maintenance of reinforcement to address the chronic nature of drug addiction A community-based trial of vocational problem-solving to increase employment among methadone patients Combining stepped-care approaches with behavioral reinforcement to motivate employment in opioid-dependent outpatients A therapeutic workplace for the long-term treatment of drug addiction and unemployment: Eight-year outcomes of a social business intervention Employment-based reinforcement of adherence to an FDA approved extended release formulation of naltrexone in opioid-dependent adults: A randomized controlled trial Financial incentives promote engagement in employment services for unemployed adults in treatment for opioid use disorder Health benefits in 2019: key: cord-294593-mh1uh1b3 authors: Boloori, Alireza; Arnetz, Bengt B.; Viens, Frederi; Maiti, Taps; Arnetz, Judith E. title: Misalignment of Stakeholder Incentives in the Opioid Crisis date: 2020-10-16 journal: keywords: care; health; incentives; management; opioid; oud; pain; patients; prescribing; providers; review; sud; treatment; use cache: cord-294593-mh1uh1b3.txt plain text: cord-294593-mh1uh1b3.txt item: #1550 of 2876 id: cord-294617-i8j36bol author: Dhar, Shabir A title: My fear, my morals: a surgeon’s perspective of the COVID crisis date: 2020-10-14 words: 1916 flesch: 63 summary: As the number and range of COVID patients needing surgical intervention grows, me and my surgical colleagues are increasingly realizing that we have to join the battle at the deep end, first up. Even as one department is designated entirely for operating only COVID positive patients, we wonder how long their forbearance will last. keywords: choice; pandemic; patient; risk; surgeon cache: cord-294617-i8j36bol.txt plain text: cord-294617-i8j36bol.txt item: #1551 of 2876 id: cord-294628-ecg13s7a author: Chia, Ming Li title: Managing COVID-19 in a Novel, Rapidly Deployable Community Isolation Quarantine Facility date: 2020-09-17 words: 3681 flesch: 49 summary: Patients who needed further investigations or were acutely ill were transferred to a general hospital via an ambulance dedicated to patients with COVID-19. This article shares the authors' experience in operating these massive-scale isolation facilities while prioritizing safety for all and ensuring holistic patient care in the face of a public health crisis and lean health care resources. keywords: care; covid-19; facility; health; hospital; isolation; monitoring; patients; singapore cache: cord-294628-ecg13s7a.txt plain text: cord-294628-ecg13s7a.txt item: #1552 of 2876 id: cord-294636-xes8g0x4 author: Brindle, Mary E. title: Approaching Surgical Triage During the COVID-19 Pandemic date: 2020-05-07 words: 2134 flesch: 45 summary: 7. Develop pathways to transfer surgical patients to centers with greater capacity if resources become scarce. Surgical systems that have not deferred nonurgent operations may be too late to mount the necessary response to COVID-19. keywords: cases; pandemic; patients; resources; triage cache: cord-294636-xes8g0x4.txt plain text: cord-294636-xes8g0x4.txt item: #1553 of 2876 id: cord-294700-pb5k21da author: Dulek, Daniel E title: Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute COVID-19 in Pediatric Patients date: 2020-08-18 words: 14549 flesch: 30 summary: A single center experience Rapid and Severe Covid-19 Pneumonia with Severe Acute Chest Syndrome in a Sickle Cell Patient Successfully Treated with Tocilizumab Off-label Use of Tocilizumab in Patients with SARS-CoV-2 Infection Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2 COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study Clinical Manifestations and Outcomes of Critically Ill Children and Adolescents with COVID-19 in New York City Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Autopsy Findings and Venous Thromboembolism in Patients With COVID-19 Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis COVID-19 and its implications for thrombosis and anticoagulation Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19 Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Type I IFN immunoprofiling in COVID-19 patients Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Favorable Anakinra Responses in Severe Covid-19 Patients with Secondary Hemophagocytic Lymphohistiocytosis Tocilizumab for the treatment of severe coronavirus disease 2019 Interleukin-6: A Masterplayer in the Cytokine Network Impaired immune and acute-phase responses in interleukin-6-deficient mice Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection HBV replication is significantly reduced by IL-6 Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis Up-regulation of IL-6 and TNF-alpha induced by SARS-coronavirus spike protein in murine macrophages via NF-kappaB pathway Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB Lack of innate interferon responses during SARS coronavirus infection in a vaccination and reinfection ferret model Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding Tocilizumab for treatment of mechanically ventilated patients with COVID-19 Tocilizumab in patients with severe COVID-19: a retrospective cohort study Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized COVID-19 Patients: Survival and Clinical Outcomes Pilot prospective open, single-arm multicentre study on offlabel use of tocilizumab in patients with severe COVID-19 Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study Effective treatment of severe COVID-19 patients with tocilizumab Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: A single center study of 100 patients in Pneumatosis Intestinalis and Intestinal Perforation in a Transaminase Levels and Hepatic Events During Tocilizumab Treatment: Pooled Analysis of Long-Term Clinical Trial Safety Data in Rheumatoid Arthritis Letter to the Editor: Acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab Anakinra for severe forms of COVID-19: a cohort study Canakinumab in a subgroup of patients with COVID-19 Critical regulation of early Th17 cell differentiation by interleukin-1 signaling Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1 Anakinra Therapy for Non-cancer Inflammatory Diseases Rilonacept and canakinumab European Group Of Clinical I. Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate Randomized, double-blind, placebo-controlled trial of the efficacy and safety of rilonacept in the treatment of systemic juvenile idiopathic arthritis Efficacy and safety of rilonacept Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes Highlights of Prescribing Information Critical Assessment of Pharmacokinetic Drug-Drug Interaction Potential of Tofacitinib, Baricitinib and Upadacitinib, the Three Approved Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment The convalescent sera option for containing COVID-19 Use of convalescent plasma therapy in SARS patients in Hong Kong Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Treatment With Convalescent Plasma for Critically Ill Patients With SARS-CoV-2 Infection Effectiveness of convalescent plasma therapy in severe COVID-19 patients Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea Treatment with convalescent plasma for COVID-19 patients in Wuhan Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19: A Randomized Clinical Trial Profile of IgG and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Antibody responses to SARS-CoV-2 in patients with COVID-19 Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19 Effect of Convalescent Plasma Therapy on Viral Shedding and Survival in COVID-19 Patients First case of convalescent plasma transfusion in a child with COVID-19-associated severe aplastic anemia Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry Administration FaD Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection Passively acquired antibodies suppress humoral but not cell-mediated immunity in mice immunized with live attenuated respiratory syncytial virus vaccines Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infection Deployment of convalescent plasma for the prevention and treatment of COVID-19 Currently available intravenous immunoglobulin contains antibodies reacting against severe acute respiratory syndrome coronavirus 2 antigens Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14+CD16++ monocytes in common variable immunodeficiency (CVID) patients Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis Update on the use of immunoglobulin in human disease: A review of evidence Interleukin 1 Receptor Antagonist Anakinra, Intravenous Immunoglobulin, and Corticosteroids in the Management of Critically Ill Adult Patients With Hemophagocytic Lymphohistiocytosis Thrombocytopenia in patients with severe acute respiratory syndrome (review) Incidence and Outcome of Severe and Nonsevere Thrombocytopenia Associated With Zika Virus Infection-Puerto Rico Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis Macrophage Activation Syndrome High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease Type I interferons in infectious disease Interferon-lambda orchestrates innate and adaptive mucosal immune responses COVID-19 and emerging viral infections: The case for interferon lambda A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection 96weeks treatment of tenofovir alafenamide vs. tenofovir disoproxil fumarate for hepatitis B virus infection Korean Association for the Study of the L. KASL clinical practice guidelines for management of chronic hepatitis B keywords: acute; anakinra; children; clinical; coronavirus; cov-2; covid-19; covid-19 patients; cytokine; data; disease; evidence; infection; inflammatory; p t; patients; pediatric; sars; studies; syndrome; therapy; tocilizumab; treatment; use cache: cord-294700-pb5k21da.txt plain text: cord-294700-pb5k21da.txt item: #1554 of 2876 id: cord-294768-bs6thjw2 author: Alonso-Fernández, Alberto title: Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective study date: 2020-08-25 words: 4656 flesch: 43 summary: D-dimer, platelet count, and, C reactive protein values were significantly higher among PE patients. The proportion of patients with PE diagnosed during the first days (when laboratory data was obtained by protocol) was higher (66.7%) than the proportion of PE patients diagnosed during follow-up (when laboratory data was obtained at the discretion of the clinician) (42.9%). keywords: covid-19; dimer; patients; pneumonia; pulmonary; risk; study; values cache: cord-294768-bs6thjw2.txt plain text: cord-294768-bs6thjw2.txt item: #1555 of 2876 id: cord-294788-9usyb1nn author: Baek, Woong Kee title: A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2 date: 2020-05-03 words: 4478 flesch: 41 summary: Patients with mild symptoms presented with an elevation of cytokines within the reference ranges, while severe patients showed markedly elevated levels [19] . The pathophysiology behind the peripheral leukopenia in severe patients is not fully understood. keywords: cells; coronavirus; cov-2; covid-19; disease; infection; patients; sars; symptoms; syndrome cache: cord-294788-9usyb1nn.txt plain text: cord-294788-9usyb1nn.txt item: #1556 of 2876 id: cord-294810-mq9vjnro author: Huang, Qiong title: Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China date: 2020-05-14 words: 3441 flesch: 49 summary: Severe COVID-19 patients present with any of the following: (1) shortness of breath, plus respiratory rate ≥ 30 breaths/min, (2) in resting state, oxygen saturation (SpO2) ≤ 93%, and 3) arterial partial pressure of oxygen (PaO2)/Fraction of inspiration oxygen (FiO2) ≤ 300 mmHg. Objective The study was aimed to describe the clinical characteristics, laboratory parameters, and therapeutic methods of COVID-19 patients in Hunan, China. keywords: coronavirus; covid-19; disease; patients; study; symptoms; treatment; type; wuhan cache: cord-294810-mq9vjnro.txt plain text: cord-294810-mq9vjnro.txt item: #1557 of 2876 id: cord-294907-i836d6im author: Alabdali, Abdullah title: The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak at King Abdul-Aziz Medical City-Riyadh from Emergency Medical Services Perspective date: 2020-05-20 words: 3297 flesch: 44 summary: The high mortality rate in MERS-CoV and high health-care-associated infections, including health care personnel acquired infections, required local hospitals to ensure that ambulance services personnel understand the risk of transporting such patients. This article reported the overall experience of a Saudi hospitalbased Emergency Medical Services (EMS) system with MERS-CoV: logistics of transfer, transfer policies, methods of monitoring personnel with CoV exposure, and training provided to EMS personnel. keywords: ambulance; cases; cov; ems; medical; mers; outbreak; patients cache: cord-294907-i836d6im.txt plain text: cord-294907-i836d6im.txt item: #1558 of 2876 id: cord-294933-oc2glu4a author: Cinesi Gómez, César title: Clinical consensus recommendations regarding non-invasive respiratory support in the adult patient with acute respiratory failure secondary to SARS-CoV-2 infection date: 2020-06-19 words: 5647 flesch: 39 summary: An official clinical practice guideline of the Severe acute respiratory syndrome (SARS) ---lessons for future pandemics MERS transmission and risk factors: a systematic review Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza Highlights in acute respiratory failure High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure British Thoracic Society/Intensive Care Society Guideline for the ventilatory management of acute hypercapnic respiratory failure in adults Extracorporeal membrane oxygenation for critically ill adults Noninvasive ventilation in acute hypercapnic respiratory failure Effectiveness of noninvasive positive pressure ventilation in the treatment of acute respiratory failure in severe acute respiratory syndrome Noninvasive mechanical ventilation in severe pneumonia due to H1N1 virus Pandemic 2009 influenza A in Argentina: a study of 337 patients on mechanical ventilation Early non-invasive ventilation treatment for severe influenza pneumonia Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists. A fundamental element in the management of ARF in COVID-19 patients in monitoring ---preferably of a non-invasive nature. keywords: covid-19; disease; failure; flow; healthcare; infection; management; nasal; nimv; oxygen; patients; sars; therapy; use; ventilation cache: cord-294933-oc2glu4a.txt plain text: cord-294933-oc2glu4a.txt item: #1559 of 2876 id: cord-294959-xy8976jz author: Hsu, Elisabeth title: Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage date: 2020-06-30 words: 977 flesch: 61 summary: Other patients who were in the early or mild stage recovered much sooner, usually within three to four days taking Allium fistulosum congee. key: cord-294959-xy8976jz authors: Hsu, Elisabeth; Zhu, Buxian; Ding, Zewan title: Allium fistulosum congee as a home remedy to ward off the corona virus at an early stage date: 2020-06-30 journal: keywords: allium; fistulosum; stage cache: cord-294959-xy8976jz.txt plain text: cord-294959-xy8976jz.txt item: #1560 of 2876 id: cord-294969-57xgqf2g author: Green, Bart N. title: Rapid Deployment of Chiropractic Telehealth at 2 Worksite Health Centers in Response to the COVID-19 Pandemic: Observations from the Field date: 2020-06-11 words: 5988 flesch: 49 summary: WSHCs are clinics where employees, and sometimes the dependents of employees, have access to a variety of health care services at or near the workplace of the employees. This is a descriptive report of how we transitioned from in-clinic to telehealth care during the COVID-19 pandemic. keywords: care; chiropractic; clinic; covid-19; home; patient; rtvc; services; telehealth; time; use; video cache: cord-294969-57xgqf2g.txt plain text: cord-294969-57xgqf2g.txt item: #1561 of 2876 id: cord-295086-tc3re52f author: Lu, Guoguang title: Dynamic changes in routine blood parameters of a severe COVID-19 case date: 2020-05-13 words: 1751 flesch: 45 summary: Dynamic changes in routine blood parameters might be helpful for the prognosis of COVID-19 patients and evaluation of the treatment effect. Currently, the number of COVID-19 patients is rapidly increasing worldwide, and some countries and regions, such as Africa, lack medical resources [2] . keywords: admission; blood; day; patient cache: cord-295086-tc3re52f.txt plain text: cord-295086-tc3re52f.txt item: #1562 of 2876 id: cord-295123-x2gxgave author: Zhou, Wei title: Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia date: 2020-02-21 words: 1726 flesch: 28 summary: Besides, salvage corticosteroids treatment for severe patients with advanced ARDS could alleviate the pulmonary fibrosis and prevent progressive pathological deterioration 11 , which provides a good framework for explaining why some critical patients with SARS infection benefit from rescue corticosteroids therapy. Of note, as documented in a series of randomized clinical trials (RCT), low or physiologic dose of corticosteroids treatment did not reduce mortality from septic shock caused by primary lung infections, but it could bring clinical benefits to secondary outcomes, such as earlier reversal of shock, shorter duration to exit from ICU and mechanical ventilation 9, 10 . keywords: corticosteroids; ncov; patients; therapy; treatment cache: cord-295123-x2gxgave.txt plain text: cord-295123-x2gxgave.txt item: #1563 of 2876 id: cord-295144-tyyc81uc author: Stradner, Martin H. title: Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic date: 2020-10-09 words: 9915 flesch: 28 summary: A single center experience Efficacy and safety of tocilizumab in severe COVID-19 patients: a single-centre retrospective cohort study Interleukin-6 receptor blocking with intravenous tocilizumab in COVID-19 severe acute respiratory distress syndrome: a retrospective case-control survival analysis of 128 patients Tocilizumab in patients with severe COVID-19: a retrospective cohort study Interleukin-6 receptor blockade with subcutaneous tocilizumab in severe COVID-19 pneumonia and hyperinflammation: a case-control study Outcomes in patients with severe COVID-19 disease treated with tocilizumab -a case-controlled study Tocilizumab for treatment of mechanically ventilated patients with COVID-19. Pre-publication reports describe a specific monocyte population in COVID-19 patients, not seen in healthy donors or other viral infections. keywords: case; clinical; cohort; coronavirus; course; cov-2; covid-19; disease; infection; inflammatory; patients; risk; rmd; sars; study; syndrome; treatment cache: cord-295144-tyyc81uc.txt plain text: cord-295144-tyyc81uc.txt item: #1564 of 2876 id: cord-295216-eff02z0i author: Ahluwalia, Ranbir title: The impact of imposed delay in elective pediatric neurosurgery: an informed hierarchy of need in the time of mass casualty crisis date: 2020-05-20 words: 5230 flesch: 42 summary: I malformation associated with extensive syrinx Time course of syringomyelia resolution following decompression of Chiari malformation Type I Chiari I malformation associated with syringomyelia: a retrospective study of 316 surgically treated patients Comparison of posterior fossa decompression with and without duraplasty for the surgical treatment of Chiari malformation Type I in pediatric patients: a metaanalysis Pediatric epilepsy surgery: could age be a predictor of outcomes Developmental outcome after epilepsy surgery in infancy Early and late epilepsy surgery in focal epilepsies associated with long-term epilepsy-associated tumors Factors associated with seizure freedom in the surgical resection of glioneuronal tumors Dysembryoplastic neuroepithelial tumors in childhood: long-term outcome and prognostic features Epilepsy surgery for glioneuronal tumors in childhood: avoid loss of time Endoscopic versus open repair for craniosynostosis in infants using propensity score matching to compare outcomes: a multicenter study from the Pediatric Craniofacial Collaborative group Age at time of craniosynostosis repair predicts increased complication rate. [15] noted thin-walled, small, and closely packed vascularization in pediatric patients with cerebellar hemorrhage from pilocytic astrocytomas 10]. keywords: age; cases; chiari; children; epilepsy; months; patients; pediatric; surgery; syrinx cache: cord-295216-eff02z0i.txt plain text: cord-295216-eff02z0i.txt item: #1565 of 2876 id: cord-295323-snrt9odv author: Yadav, Sandeep Kumar title: Creating Backup Management Resources for Spine Care during the Coronavirus Disease 2019 Pandemic date: 2020-05-14 words: 1138 flesch: 40 summary: We ensured that the hospital stays of postoperative patients were minimized. We share our experience with two ends of the spectra that we currently observe in spine patients. keywords: patients; time; use cache: cord-295323-snrt9odv.txt plain text: cord-295323-snrt9odv.txt item: #1566 of 2876 id: cord-295332-wlnss6bg author: AL Shareef, Khaled title: Cytokine Blood Filtration Responses in COVID-19 date: 2020-05-28 words: 2684 flesch: 44 summary: medRxiv Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19) Regulation of interferon production as a potential strategy for CO-VID-19 treatment Clinical trials on drug repositioning for CO-VID-19 treatment The epidemiology and pathogenesis of coronavirus disease (CO-VID-19) outbreak Multiscale biofluidic and nanobiotechnology approaches for treating sepsis in extracorporeal circuits Cytokine removal with high cut-off membrane: review of literature Early report: the use of Cytosorb™ haemabsorption column as an adjunct in managing severe sepsis: initial experiences, review and recommendations What have we learned about the use of cytosorb adsorption columns? Cytokine reduction in the setting of an ARDS-associated inflammatory response with multiple organ failure Severe myoglobinuric acute kidney injury in a kidney recipient: rapid recovery after hemodialysis with the super high-flux membrane Theralite® Organ dysfunction during continuous veno-venous high cut-off hemodialysis in patients with septic acute kidney injury: a prospective observational study Application of endotoxin and cytokine adsorption haemofilter in septic acute kidney injury due to Gram-negative bacterial infection Continuous renal replacement therapy with the adsorbing filter oXiris in septic patients: a case series Bodelsson M. Endotoxin and cytokine reducing properties of the oXiris membrane in patients with septic shock: a randomized crossover double-blind study Septic shock due to infected giant venous malformation complicated by massive bleeding Continuous renal replacement therapy with a polymethyl methacrylate membrane hemofilter suppresses inflammation in patients after open-heart surgery with cardiopulmonary bypass Effect of HA330 resin-directed hemoadsorption on a porcine acute respiratory distress syndrome model. The oXiris membrane has been investigated in septic shock patients for cytokine reduction. keywords: covid-19; cytokine; group; membrane; patients; treatment cache: cord-295332-wlnss6bg.txt plain text: cord-295332-wlnss6bg.txt item: #1567 of 2876 id: cord-295371-ccqne6nu author: Stoj, Victoria J. title: Dermatology residents and the care of patients with coronavirus disease 2019 (COVID-19) date: 2020-04-04 words: 611 flesch: 53 summary: Health care workers in Italy make up approximately 9% of confirmed COVID-19 cases in that country as of March 10, 2020. The bottom line is that to fulfill your obligation as a professional in the house of medicine, ensure medical care is delivered to those in need (distributive justice), help patients, and do no harm (beneficence and nonmaleficence,) and for your own dignity, do not call a lawyer! keywords: care; covid-19 cache: cord-295371-ccqne6nu.txt plain text: cord-295371-ccqne6nu.txt item: #1568 of 2876 id: cord-295414-v10454ns author: Baktash, Vadir title: Vitamin D status and outcomes for hospitalised older patients with COVID-19 date: 2020-08-26 words: 3787 flesch: 40 summary: These patients were investigated with real-time reverse transcriptase-PCR (RT-PCR) assay for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on nasopharyngeal swab, blood tests including vitamin D levels (25-hydroxyvitamin D (25(OH)D), basic observations, and chest X-ray (CXR) and/or chest CT. All patients had vitamin D levels checked in keeping with good medical practice. keywords: covid-19; deficiency; infection; outcomes; patients; serum; study; vitamin cache: cord-295414-v10454ns.txt plain text: cord-295414-v10454ns.txt item: #1569 of 2876 id: cord-295514-vhymj0rw author: Lim, Peter A title: Impact of a viral respiratory epidemic on the practice of medicine and rehabilitation: Severe acute respiratory syndrome date: 2004-08-01 words: 5282 flesch: 41 summary: Care was also taken when using nasal intermittent positive pressure ventilation devices for respiratory rehabilitation patients. Rehabilitation patients were not allowed to move around or interact with each other. keywords: care; contact; health; hospital; infection; medicine; patients; rehabilitation; sars; singapore; staff; syndrome; therapy cache: cord-295514-vhymj0rw.txt plain text: cord-295514-vhymj0rw.txt item: #1570 of 2876 id: cord-295523-5pv7kw6i author: Picchianti Diamanti, Andrea title: Cytokine Release Syndrome in COVID-19 Patients, A New Scenario for an Old Concern: The Fragile Balance between Infections and Autoimmunity date: 2020-05-08 words: 7916 flesch: 31 summary: SARS patients with a more severe disease displayed higher serum levels of pro-inflammatory cytokines (IFN-γ, IL-1, IL-6) and chemokines (including IL-8) Indeed, in CRS patients, infections principally involve the respiratory tract. keywords: activation; anti; arthritis; cells; cov-2; covid-19; crs; cytokine; disease; il-6; infection; patients; response; sars; syndrome; tnf; treatment cache: cord-295523-5pv7kw6i.txt plain text: cord-295523-5pv7kw6i.txt item: #1571 of 2876 id: cord-295700-lzaxzuwe author: Shi, Shaobo title: Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 date: 2020-05-11 words: 3846 flesch: 38 summary: Table 3 summarized the distribution of death-related complications in included patients, including ARDS (98.4%), acute respiratory failure (90.3%), acute myocardial injury (30.6%), acute heart failure (19.4%), multiple organ failure syndrome (9.7%), shock (6.5%), and sudden death (1.6%). Similar to SARS in 2003, acute respiratory distress syndrome (ARDS) is usually considered to be an acute process confined to the lungs and results in a high mortality rate in COVID-19 patients. keywords: age; covid-19; death; disease; hospital; injury; patients; risk cache: cord-295700-lzaxzuwe.txt plain text: cord-295700-lzaxzuwe.txt item: #1572 of 2876 id: cord-295703-no45mgyd author: ALTAY, O. title: Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 date: 2020-10-05 words: 3980 flesch: 43 summary: A randomized controlled trial Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis L-Carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow Acetyl-L-Carnitine Supplementation During HCV Therapy With Pegylated Interferon-α 2b Plus Ribavirin: Effect on Work Performance; A Randomized Clinical Trial Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of heart positive Serine Metabolism Supports Macrophage IL-1β Production Long-Term l-Serine Administration Reduces Food Intake and Improves Oxidative Stress and Sirt1/NFκB Signaling in the Hypothalamus of Aging Mice Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults Nicotinamide riboside is uniquely and orally bioavailable in mice and humans Extrapulmonary manifestations of COVID-19 Abnormal Liver Tests in COVID-19: A Retrospective Observational Cohort Study of 1827 Patients in a Major U.S. Hospital Network Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 Prevalence and Characteristics of Gastrointestinal Symptoms in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the United States: A Multicenter Cohort Study Abnormal liver function tests in COVID-19 patients: relevance and potential pathogenesis L-Serine Supplementation Attenuates Alcoholic Fatty Liver by Enhancing Homocysteine Metabolism in Mice and Rats Serine Is an Essential Metabolite for Effector T Cell Expansion Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Moreover, a large number of clinical trials have been performed for repositioning existing drugs for effective treatment of COVID-19 patients (7, 8) . keywords: cmcs; covid-19; day; license; medrxiv; patients; placebo; preprint; study; treatment cache: cord-295703-no45mgyd.txt plain text: cord-295703-no45mgyd.txt item: #1573 of 2876 id: cord-295794-glcg36si author: Seghers, Victor J. title: After the initial COVID-19 surge: a phased radiology departmental re-opening plan date: 2020-08-22 words: 4753 flesch: 33 summary: As radiology departments begin recovery operations, some will attempt to restore familiar routines, processes and workflows. Greater awareness of the negative impact of implicit bias within radiology departments as well as recruitment and mentorship programs to prioritize diversity and inclusion can ensure that faculty and staff better reflect the communities in which they serve. keywords: cov-2; covid-19; department; hospital; imaging; operations; patients; plan; radiology; reopening; staff; teams; testing cache: cord-295794-glcg36si.txt plain text: cord-295794-glcg36si.txt item: #1574 of 2876 id: cord-295798-x7or932x author: Ferrey, Antoney J. title: A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease date: 2020-03-28 words: 3037 flesch: 42 summary: [17] ; however, whereas an emerging agent for COVID-19 infection is remdesivir [18] , unfortunately patients with ESRD are excluded from current trials. First Case of 2019 Novel Coronavirus in the United States Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study Q&A: keywords: case; coronavirus; covid-19; day; dialysis; disease; infection; patients; symptoms cache: cord-295798-x7or932x.txt plain text: cord-295798-x7or932x.txt item: #1575 of 2876 id: cord-295800-w0dup04b author: So, Loletta K-Y title: Development of a standard treatment protocol for severe acute respiratory syndrome date: 2003-05-10 words: 2402 flesch: 42 summary: In this emerging disease that frequently has rapid deterioration, the inclusion of control patients was not possible or ethical. Staff washed hands with antiseptic rubs after every contact with patients or contaminated objects and after taking off protective garments. keywords: days; methylprednisolone; patients; syndrome; treatment cache: cord-295800-w0dup04b.txt plain text: cord-295800-w0dup04b.txt item: #1576 of 2876 id: cord-295971-jtv1jj2z author: Cho, Sun Young title: MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study date: 2016-07-09 words: 4639 flesch: 52 summary: The emergency room has its own radiology suite for emergency room patients only. Patients' demographic information, underlying disease, dates of emergency room visit, duration of stay with exact arrival and departure times, and location within the emergency room were collected. keywords: care; cov; emergency; group; infection; mers; patient; room; zone cache: cord-295971-jtv1jj2z.txt plain text: cord-295971-jtv1jj2z.txt item: #1577 of 2876 id: cord-296013-6ej3pd0u author: Trinidad, John title: Telemedicine for Inpatient Dermatology Consultations in Response to the COVID-19 Pandemic date: 2020-04-24 words: 328 flesch: 16 summary: 5 Dermatologists are poised to 58 utilize teledermatology to increase access to dermatologic care for hospitalized patients, reduce 59 the risk of infection of patients, trainees and staff, and reduce the use of precious resources such 60 as personal protective equipment (PPE) and medical supplies. Outpatient 55 teledermatology services have the potential to increase access to dermatology care, and to 56 address health care disparities for urban-underserved and rural populations. keywords: care cache: cord-296013-6ej3pd0u.txt plain text: cord-296013-6ej3pd0u.txt item: #1578 of 2876 id: cord-296018-lgx5k2kp author: Lee, Jong-Bin title: Evaluation of prognosis related to compliance with supportive periodontal treatment in patients with chronic periodontitis: a clinical retrospective study date: 2019-04-17 words: 5383 flesch: 46 summary: A summary of current work The pathogenesis of human periodontitis: an introduction Oral hygiene and maintenance of periodontal support Oral hygiene related to long-term effects of periodontal therapy Clinical periodontology and implant dentistry Compliance with supportive periodontal therapy and its relation to the bleeding index Awareness of patients with periodontal disease under treatments at initial and maintenance phase What factors influence patient compliance with supportive periodontal therapy in a general practice setting? Gender differences in reported dental fear and fear of dental pain Supportive periodontal therapy and dental implants: an analysis of patients' compliance Compliance with maintenance therapy in a private periodontal practice Supportive post-implant therapy: patient compliance rates and impacting factors: 3-year follow-up Compliance with supportive periodontal therapy Tooth loss in periodontal patients Oral microbial biofilms and plaque-related diseases: microbial communities and their role in the shift from oral health to disease Retrospective study of tooth loss in 92 treated periodontal patients Effect of supportive periodontal therapy on the prevention of tooth loss in Korean adults Impact of patient compliance on tooth loss during supportive periodontal therapy: a systematic review and meta-analysis Initial extractions and tooth loss during supportive care in a periodontal population seeking comprehensive care Retrospective evaluation of the influence of the interleukin-1 genotype on radiographic bone levels in treated periodontal patients over 10 years We certify that this study was an academic study conducted in our department and that all information in this study has been fully acknowledged. Chronic periodontitis patients were classified based on their compliance level, and factors affecting PC-SPT and the prognosis of PC-SPT were investigated. keywords: bone; patients; spt; study; teeth; treatment cache: cord-296018-lgx5k2kp.txt plain text: cord-296018-lgx5k2kp.txt item: #1579 of 2876 id: cord-296113-syi2fwuo author: Peng, Mian title: Two mechanically ventilated cases of COVID-19 successfully managed with a sequential ventilation weaning protocol: Two case reports date: 2020-08-06 words: 2624 flesch: 45 summary: A MV protocol attentive to intubation/extubation timing, prone positioning early in MV, infection control, and sequential withdrawal of respiratory support, may be an effective regimen for patients with critical COVID-19. The viral pathogen severe acute respiratory syndrome-related novel coronavirus (SARS-CoV-2, also known as 2019 novel coronavirus or 2019-nCoV), which has been determined to have originated in Wuhan, China, has infected patients around the globe and produced the ongoing grave pandemic keywords: coronavirus; covid-19; patients; sars; weaning cache: cord-296113-syi2fwuo.txt plain text: cord-296113-syi2fwuo.txt item: #1580 of 2876 id: cord-296182-hhswage4 author: Meng, Lingzhong title: Intubation and Ventilation amid the COVID-19 Outbreak: Wuhan’s Experience date: 2020-04-08 words: 6539 flesch: 37 summary: Ventilator management for hypoxemic respiratory failure attributable to H1N1 novel swine origin influenza virus High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome Nursing and infection-control issues during high-frequency oscillatory ventilation Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome: A comparison between volume and pressure-regulated breathing modes Ventilator management for acute respiratory distress syndrome associated with avian influenza A (H7N9) virus infection: A case series Prone positioning in severe acute respiratory distress syndrome Lung recruitment maneuvers for ARDS patients: A systematic review and meta-analysis Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation ACURASYS Study Investigators: Neuromuscular blockers in early acute respiratory distress syndrome Early neuromuscular blockade in the acute respiratory distress syndrome Neuromuscular blockade in acute respiratory distress syndrome: A systematic review and meta-analysis of randomized controlled trials ESICM H1N1 Registry Contributors: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1) v influenza A infection Corticosteroids as adjunctive therapy in the treatment of influenza Corticosteroids as adjunctive therapy in the treatment of influenza: An updated Cochrane systematic review and meta-analysis González-Martín JM; dexamethasone in ARDS network: Dexamethasone treatment for the acute respiratory distress syndrome: A multicentre, randomised controlled trial Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) acute respiratory distress syndrome Extracorporeal life support: The next step in moderate to severe ARDS-A review and meta-analysis of the literature Elbourne D; CESAR trial collaboration: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomised controlled trial Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc Bayesian analysis of a randomized clinical trial A novel coronavirus outbreak of global health concern A review of isolation gowns in healthcare: Fabric and gown properties Prone position for acute respiratory distress syndrome. Approximately 3.2% of patients with COVID-19 required intubation and invasive ventilation at some point in the disease course. keywords: airway; china; covid-19; infection; intubation; lung; oxygenation; patients; pressure; syndrome; ventilation; wuhan cache: cord-296182-hhswage4.txt plain text: cord-296182-hhswage4.txt item: #1581 of 2876 id: cord-296219-zzg9hds0 author: Battaglini, Denise title: Neurological Manifestations of Severe SARS-CoV-2 Infection: Potential Mechanisms and Implications of Individualized Mechanical Ventilation Settings date: 2020-08-12 words: 7500 flesch: 24 summary: Furthermore, mechanical ventilation, commonly used in the management of COVID-19 patients, can itself induce an inflammatory response, causing distal organ failure. Despite the paucity of evidence, there are three key hypotheses for the neurological manifestations of COVID-19 patients (Figure 1) : (1) viral neurotropism; (2) a hyperinflammatory and hypercoagulable state; and (3) brainlung crosstalk. keywords: acute; brain; cells; coronavirus; cov-2; covid-19; disease; infection; levels; lung; oxygen; patients; pressure; sars; study; syndrome cache: cord-296219-zzg9hds0.txt plain text: cord-296219-zzg9hds0.txt item: #1582 of 2876 id: cord-296331-i4hyzqcv author: Adapa, Sreedhar title: COVID-19 Pandemic Causing Acute Kidney Injury and Impact on Patients With Chronic Kidney Disease and Renal Transplantation date: 2020-06-04 words: 5101 flesch: 47 summary: medRxiv Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Clinical Characteristics of Coronavirus Disease 2019 in China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Critically Ill Patients With COVID-19 in Washington State A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 Clinical features and treatment of COVID-19 patients in northeast Chongqing Clinical Features of Patients Infected with the 2019 Novel Coronavirus (COVID-19 Coronavirus epidemic: preparing for extracorporeal organ support in intensive care Blood Purification Therapy and Engineering Technology Branch of the Chinese Medical Advocacy Council, and the Blood Purification Therapeutic Committee of the Army. medRxiv Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Kidney impairment is associated with in-hospital death of COVID-19 patients. keywords: aki; coronavirus; covid-19; creatinine; disease; infection; kidney; mortality; ncov; patients; sars; studies; transplant cache: cord-296331-i4hyzqcv.txt plain text: cord-296331-i4hyzqcv.txt item: #1583 of 2876 id: cord-296440-18vpg419 author: Beurnier, Antoine title: Characteristics and outcomes of asthmatic patients with COVID-19 pneumonia who require hospitalisation date: 2020-07-30 words: 3554 flesch: 44 summary: Indeed, sputum analysis showed that ACE2 expression levels are significantly lower in asthma patients taking ICS than in those not taking ICS, especially when high doses are administrated [19] . However, more concern has been recently raised about thrombosis and pulmonary embolism in COVID-19 patients [28] , underscoring that this complication may be more prevalent in this patient population. keywords: asthma; asthmatics; cases; covid-19; non; patients; pneumonia; sars cache: cord-296440-18vpg419.txt plain text: cord-296440-18vpg419.txt item: #1584 of 2876 id: cord-296494-6kn4mr04 author: Saban-Ruiz, J. title: COVID-19: A Personalized Cardiometabolic Approach for Reducing Complications and Costs. The Role of Aging Beyond Topics date: 2020-05-12 words: 6450 flesch: 39 summary: Even more interesting, taking into account that at least 50% of COVID-19 patients have hyperglycaemia on admission or in the first days of hospitalization (25) , the transmembrane domain has a potential N-glycation site (26) that in COVID-19 would deserve further research. COVID-19 patients who develop myocardial injury, usually DM and/or elderly patients, have a more acute presentation, with higher incidence of ADSR and more frequent need for assisted ventilation than those without myocardial injury (64) . keywords: ace2; acute; aging; cardiometabolic; cardiovascular; coronavirus; covid-19; diabetes; disease; failure; heart; patients; risk; sars cache: cord-296494-6kn4mr04.txt plain text: cord-296494-6kn4mr04.txt item: #1585 of 2876 id: cord-296562-3h2oqb9k author: Guillén, Lucía title: Preemptive interleukin-6 blockade in patients with COVID-19 date: 2020-10-08 words: 4881 flesch: 36 summary: Baseline levels and the initial response after TCZ administration of some biomarkers were also useful to predict the clinical outcome; a lower NLR on admission, and lower platelet/d-dimer ratio and hs-cardiac troponin I at 48 h following TCZ initiation were associated with favorable TCZ response. Baseline characteristics of included patients are shown in Table 1 . keywords: biomarkers; covid-19; disease; il-6; levels; non; patients; responders; response; tcz; therapy; tocilizumab cache: cord-296562-3h2oqb9k.txt plain text: cord-296562-3h2oqb9k.txt item: #1586 of 2876 id: cord-296588-q2716lda author: Hanson, Kimberly E title: Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19 date: 2020-06-16 words: 10186 flesch: 40 summary: In addition, the limited data showing poor outcomes in COVID-19 positive patients undergoing a major surgical procedure requiring intubation informed decisions to reduce this risk for asymptomatic patients We also did not identify test accuracy studies directly assessing the performance of SARS-CoV-2 NAATs in asymptomatic individuals. keywords: asymptomatic; c r; cov-2; covid-19; evidence; individuals; p t; patients; s c; sars; studies; test; testing cache: cord-296588-q2716lda.txt plain text: cord-296588-q2716lda.txt item: #1587 of 2876 id: cord-296605-p67twx7a author: LAU, Arthur Chun-Wing title: Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS) date: 2004-03-10 words: 4848 flesch: 34 summary: In this article, we aim to focus on the management of the subgroup of SARS patients who are critically ill. In one-third to half of SARS patients, fever may recur while on immunomodulatory treatment due to superimposed infections, too rapid tailing of corticosteroids or persistently severe and uninhibited cytokine storm. keywords: acute; clinical; corticosteroids; failure; icu; infection; patients; pressure; sars; syndrome; treatment; ventilation cache: cord-296605-p67twx7a.txt plain text: cord-296605-p67twx7a.txt item: #1588 of 2876 id: cord-296607-h2zwlyz7 author: Watson, Ryan A. title: Anti-coagulant and anti-platelet therapy in the COVID-19 patient: a best practices quality initiative across a large health system date: 2020-06-09 words: 7740 flesch: 32 summary: COVID-19 patients may present with hemodynamic instability and increased biomarkers of cardiac injury, specifically troponin and B-Type Natriuretic Peptide. COVID-19 patients, commonly present with shortness of breath secondary to viral pneumonia with critically ill patients progressing to acute respiratory distress syndrome (ARDS). keywords: american; anticoagulation; bleeding; covid-19; disease; fibrillation; management; mortality; patients; prophylaxis; risk; stroke; therapy; thrombosis; use cache: cord-296607-h2zwlyz7.txt plain text: cord-296607-h2zwlyz7.txt item: #1589 of 2876 id: cord-296676-2anl2agl author: Goldberg, Michael F. title: Neuroradiologic manifestations of COVID-19: what the emergency radiologist needs to know date: 2020-08-21 words: 4172 flesch: 40 summary: Retrospective observational study of brain magnetic resonance imaging findings in patients with acute SARS-CoV-2 infection and neurological manifestations SARS2-CoV-2 and stroke in a New York healthcare system Neurologic features in severe SARS-CoV-2 infection Large-vessel stroke as a presenting feature of Covid-19 in the young Cerebrovascular disease in COVID-19 SARS2-CoV-2 and stroke in a New York healthcare system Urgent carotid endarterectomy in a COVID-19 patient: standard approach with some adjustments Neurovascular complications in COVID-19 infection: case series Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical features and treatment of COVID-19 patients in Northeast Chongqing Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Analysis of risk factors for the thromboembolic events from 88 patients with COVID-19 pneumonia in Wuhan, China: a retrospective report Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 Endothelial cell infection and endotheliitis in COVID-19 SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Uriel N (2020) COVID-19 and cardiovascular disease Large artery ischaemic stroke in severe acute respiratory syndrome (SARS) A report from a large medical system in New York City reported a 0.9% incidence of acute ischemic stroke (AIS) in 3556 hospitalized COVID-19 patients in the spring of 2020 keywords: brain; case; cov-2; covid-19; disease; infection; patients; sars cache: cord-296676-2anl2agl.txt plain text: cord-296676-2anl2agl.txt item: #1590 of 2876 id: cord-296694-2js639bk author: Price, Laura C title: Thrombosis and COVID-19 pneumonia: the clot thickens! date: 2020-06-18 words: 2397 flesch: 34 summary: Patients: Awareness of an Increased Prevalence High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis VTE Incidence and Risk Factors in Patients With Severe Sepsis and Septic Shock Endothelial cell infection and endotheliitis in COVID-19 Clinical and immunological features of severe and moderate coronavirus disease 2019 COVID-19 and its implications for thrombosis and anticoagulation Hypercoagulability of COVID-19 patients in Intensive Care Unit. In this edition of the European Respiratory Journal, Bompard et al. refine this further by describing a 50% cumulative incidence of pulmonary embolism (PE), diagnosed by CT-pulmonary angiogram (PA), in COVID-19 patients admitted to ICU in two hospitals of the University of Paris (ERJ ref Bompard). keywords: anticoagulation; coronavirus; covid-19; icu; patients; thrombosis cache: cord-296694-2js639bk.txt plain text: cord-296694-2js639bk.txt item: #1591 of 2876 id: cord-296773-5o4hr6ir author: Zeneli, A. title: Mitigating strategies and nursing response for cancer care management during the COVID‐19 pandemic: an Italian experience date: 2020-10-02 words: 4702 flesch: 33 summary: This enabled us to provide planned cancer treatments and diagnostic To minimize the overall risk of poor outcomes in cancer patients treated in our centre by ensuring treatment continuity and by protecting patients, caregivers and healthcare professionals from the SARS-CoV-2 infection Patient, caregiver and employee safety, patient health outcomes, use of resources Adopted strategies and instruments for achieving goals Risk assessment to screen those with flu-like symptoms and refer them to their general practitioner for early communication, isolation and treatment for COVID-19 to prevent severe disease; telephone triage of patients before planning their visit to hospital; triaging patients and their caregivers before their access to cancer services; Continuity of essential services, appropriate case management Communication instruments An ad hoc computerized triage tool to support healthcare professionals in the decision-making process and in documenting their evaluations (Fig. 1) Establishment of a separate and dedicated pathway inside the hospital for the clinical and instrumental assessment of suspected COVID-19 cases; creation of separate itineraries within the hospital for administration staff and for healthcare professionals and patients (Fig. 2) ; reorganization of waiting rooms and common areas such as cafeterias and meeting rooms to favour social distancing; dedicated and easily noticeable stations in each cancer service containing PPEs and ready-to-use kits for surface cleaning and disinfection of reusable devices and surfaces between patients; controlling the access of lay caregivers accompanying patients to the healthcare environment to limit the spread of the virus by promoting social distancing and by reducing the number of people inside the hospital building; introduction of smart working for administration staff, procedures whilst maintaining a safe environment for patients and healthcare professionals. This was obviously a sensitive issue because of the complex needs of cancer patients. keywords: cancer; covid-19; emergency; healthcare; nurses; nursing; pandemic; patients; policies; professionals; response cache: cord-296773-5o4hr6ir.txt plain text: cord-296773-5o4hr6ir.txt item: #1592 of 2876 id: cord-296881-2g81sjnl author: Nabil, Ahmed title: Current coronavirus (SARS-CoV-2) epidemiological, diagnostic and therapeutic approaches: An updated review until June 2020 date: 2020-07-20 words: 4818 flesch: 30 summary: COVID-19 patients observed to have a dysfunction in the renin-angiotensin system (RAS). MSCs transplantation improved the outcome of COVID-19 patients. keywords: acute; cases; cells; coronavirus; cov-2; covid-19; disease; effects; infection; patients; potential; sars; treatment cache: cord-296881-2g81sjnl.txt plain text: cord-296881-2g81sjnl.txt item: #1593 of 2876 id: cord-296936-5gkx4jxa author: An, M. H. title: Treatment Response to Hydroxychloroquine and Antibiotics for mild to moderate COVID-19: a retrospective cohort study from South Korea date: 2020-07-07 words: 3791 flesch: 42 summary: Based on a recent study from China, about 80% of COVID-19 patients show non-severe symptoms(3) The authors reviewed the electronic medical records of included patients and collected epidemiological, clinical, historical, laboratory, and treatment outcomes data. keywords: covid-19; hydroxychloroquine; license; patients; preprint; study; treatment cache: cord-296936-5gkx4jxa.txt plain text: cord-296936-5gkx4jxa.txt item: #1594 of 2876 id: cord-297001-4g3wb8qi author: Tal, Shir title: Venous Thromboembolism Complicated with COVID-19: What Do We Know So Far? date: 2020-05-12 words: 4638 flesch: 44 summary: In view of the high thromboembolic risk in patients with COVID-19 despite anticoagulation treatment [14] , and in view of the thrombotic coagulopathy and extremely high D-dimers with no evidence of clinical bleeding in COVID-19 patients, some institutes like our own recommend considering higher prophylactic doses of anticoagulation such as enoxaparin 0.5 mg/kg b.i.d. or enoxaparin 1mg/kg once daily. In addition, antiphospholipid antibodies that can arise transiently in patients with critical illness and various infections may possibly develop among COVID-19 patients as well. keywords: coronavirus; covid-19; diagnosis; dimer; disease; patients; risk; treatment; vte cache: cord-297001-4g3wb8qi.txt plain text: cord-297001-4g3wb8qi.txt item: #1595 of 2876 id: cord-297093-ld89vmct author: Clark, Kristina E N title: Safety of intravenous Anakinra in COVID-19 with evidence of hyperinflammation, a case series date: 2020-08-04 words: 3245 flesch: 41 summary: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical features of patients infected with 2019 novel coronavirus in Wuhan The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality COVID-19: Immunology and treatment options Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients A Dynamic Immune Response Shapes COVID-19 Progression. Our aim is to report our experience on the beneficial effects of intravenous anakinra in patients with SARS-CoV-2 and evidence of hyperinflammation. keywords: anakinra; covid-19; day; days; ferritin; patients; use cache: cord-297093-ld89vmct.txt plain text: cord-297093-ld89vmct.txt item: #1596 of 2876 id: cord-297127-nhgm09db author: Hasseli, Rebecca title: National registry for patients with inflammatory rheumatic diseases (IRD) infected with SARS-CoV-2 in Germany (ReCoVery): a valuable mean to gain rapid and reliable knowledge of the clinical course of SARS-CoV-2 infections in patients with IRD date: 2020-09-02 words: 4096 flesch: 40 summary: With recruitment of more patients in the near future the trend of lower hospitalisation rates in patients with IRD treated with bDMARDs compared to those treated with csDMARDs will be further investigated. (D) Distribution of comorbidities (in %): 41% had no comorbidities, 37% suffered from AHT, 15% from other relevant comorbidities, 13% from CVD, 9% each from bronchial asthma and DM, 8% each from COPD and CRF, 6% from OSP, 5% from cancer/history of cancer, 2% from ILD, 1% from PAH and 15% from other relevant comorbidities, 30% had more than two comorbidities. keywords: course; cov-2; covid-19; disease; infection; ird; patients; risk; sars cache: cord-297127-nhgm09db.txt plain text: cord-297127-nhgm09db.txt item: #1597 of 2876 id: cord-297132-lhfa9fl5 author: Aghagoli, Ghazal title: Neurological Involvement in COVID-19 and Potential Mechanisms: A Review date: 2020-07-13 words: 5953 flesch: 31 summary: Clin Basic Evid Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Neuroinvasion by human respiratory coronaviruses Activation of glial cells by human coronavirus OC43 infection Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan Detection of coronavirus RNA and antigen in multiple sclerosis brain Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-α Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2 Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Awareness of the possible neurological manifestations in COVID-19 patients is of utmost importance to assist providers in the recognition, treatment, and management of potentially life-threatening neurologic complications. keywords: ace2; acute; brain; cells; clinical; coronavirus; cov-2; covid-19; human; infection; injury; patients; sars cache: cord-297132-lhfa9fl5.txt plain text: cord-297132-lhfa9fl5.txt item: #1598 of 2876 id: cord-297138-t8b3914h author: Duijker, G. title: Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial date: 2015-04-02 words: 6835 flesch: 43 summary: The distributions of the daily WURSS-21 scores in virus-positive intervention and control group patients are depicted in Fig. Even in the sub-sample of virus positive patients, our sample was very heterogeneous as several types of viruses were identified. keywords: crp; data; day; group; influenza; intervention; patients; placebo; plants; study; symptoms; time; virus; wurss-21 cache: cord-297138-t8b3914h.txt plain text: cord-297138-t8b3914h.txt item: #1599 of 2876 id: cord-297208-f4ob3ox6 author: Pisano, Antonio title: Cardiothoracic surgery at the time of COVID-19 pandemic: lessons from the East (and from a previous epidemic) for western battlefields date: 2020-05-06 words: 1377 flesch: 19 summary: 6 report other important measures which, in our opinion, should be shared at a nationwide (or at least regional) level, particularly the division of staff members into separate surgical teams (to avoid, as mentioned, cross-contamination among healthcare workers in case of accidental exposure to undiagnosed COVID-19 patients), the clear distinction of personnel caring for COVID-19 patients from that caring for other patients (including with regard to highly skilled teams such as those of extracorporeal membrane oxygenation services), and the need for infectious disease specialist consultation and agreement of the heads of both cardiology and cardiothoracic surgery departments before admitting any new patient. Given the wide spread of contagion (which is likely largely underestimated due to the hypothesized high number of asymptomatic or mildly symptomatic infections 5,12 ), the major concern of clinicians who are not directly involved in the care of COVID-19 patients, but work in high-specialty settings such as cardiac surgery, is the inadvertent admission of patients with undiagnosed SARS-CoV-2 infection, with the consequent risk of spreading contagion among healthcare workers but especially among patients whose comorbidities and clinical conditions possibly predispose them to worse outcomes following SARS-CoV-2 infection. keywords: cardiothoracic; covid-19; patients; surgery cache: cord-297208-f4ob3ox6.txt plain text: cord-297208-f4ob3ox6.txt item: #1600 of 2876 id: cord-297327-19dfgfz6 author: Drożdżal, Sylwester title: COVID-19: Pain Management in Patients with SARS-CoV-2 Infection—Molecular Mechanisms, Challenges, and Perspectives date: 2020-07-20 words: 5681 flesch: 37 summary: This narrative review summarizes current knowledge regarding challenges associated with pain assessment and management in COVID-19 patients. It is believed that myalgia in COVID-19 patients might reflect the generalized inflammation and cytokine response [34] . keywords: coronavirus; cov-2; covid-19; disease; effects; infection; management; opioids; pain; patients; sars; symptoms; treatment; use cache: cord-297327-19dfgfz6.txt plain text: cord-297327-19dfgfz6.txt item: #1601 of 2876 id: cord-297414-zq16s9ud author: Koh, Adrian H. C. title: What COVID-19 has taught us: lessons from around the globe date: 2020-06-13 words: 1780 flesch: 43 summary: This is especially important for patients at higher risk of contracting the virus, such as elderly patients, and those who are immunocompromised such as diabetic patients. Tele-ophthalmology refers to the practice of caring for patients remotely when the ophthalmologist and patient are not physically present with each other [9] . keywords: care; covid-19; health; ophthalmology; pandemic; patients; telemedicine cache: cord-297414-zq16s9ud.txt plain text: cord-297414-zq16s9ud.txt item: #1602 of 2876 id: cord-297425-vcqqssm8 author: Aries, James A. title: Clinical Outcome of Coronavirus Disease 2019 in Haemato‐oncology Patients date: 2020-05-18 words: 1404 flesch: 40 summary: The initial reports from China show that patients with cancer are over‐represented among individuals who develop severe Covid‐19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. (3) The initial reports from China show that patients with cancer are over-represented among individuals who develop severe Covid-19 after contracting the virus.(4) Patients with haematological malignancies are expected to be at increased risk of adverse outcomes from this viral infection, due being immunosuppressed as a consequence of the underlying cancer, and from the effects of therapy. keywords: cancer; covid-19; disease; patients cache: cord-297425-vcqqssm8.txt plain text: cord-297425-vcqqssm8.txt item: #1603 of 2876 id: cord-297494-6yxmaihl author: Katsurada, Naoko title: The impact of virus infections on pneumonia mortality is complex in adults: a prospective multicentre observational study date: 2017-12-06 words: 4343 flesch: 37 summary: This multicentre prospective study enrolled pneumonia patients aged ≥15 years from September 2011 to August 2014. Studies have shown that viral infection is common in pneumonia patients keywords: comorbidities; disease; influenza; mortality; patients; pneumonia; study; viruses cache: cord-297494-6yxmaihl.txt plain text: cord-297494-6yxmaihl.txt item: #1604 of 2876 id: cord-297506-1xjgsz4y author: Jansen, Jaclyn H. title: A novel presentation of COVID-19 via community acquired infection date: 2020-03-31 words: 498 flesch: 60 summary: On follow-up, patient tested positive for COVID-19 with declining respiratory status over the next 24 h. Features, evaluation and treatment coronavirus (COVID-19) Clinical characteristics of coronavirus disease 2019 in china Update: public health response to the coronavirus disease 2019 outbreak -United States keywords: covid-19; patient cache: cord-297506-1xjgsz4y.txt plain text: cord-297506-1xjgsz4y.txt item: #1605 of 2876 id: cord-297518-6y2uzcde author: Leulseged, T. W. title: Determinants of Developing Symptomatic Disease in Ethiopian COVID-19 Patients date: 2020-10-13 words: 3325 flesch: 44 summary: The aim of the study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia. Results: The result of the multivariable binary logistic regression shows that age group (AOR= 1.818, 95% CI= 1.210, 2.731, p-value=0.004 for 30-39 years; AOR= 1.611, 95% CI= 1.016, 2.554, p-value=0.043 for 40-49 years and AOR= 4.076, 95% CI= 2.582, 6.435, p-value=0.0001 for years and above), sex (AOR= 1.672, 95% CI= 1.216, 2.299, p-value=0.002) and history of diabetes mellitus (AOR= 2.406, 95% CI= 1.384, 4.181, p-value=0.002) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients. keywords: covid-19; disease; license; patients; preprint; symptomatic; symptoms cache: cord-297518-6y2uzcde.txt plain text: cord-297518-6y2uzcde.txt item: #1606 of 2876 id: cord-297532-ktiwfcop author: De Fata Salvatores, Gaia title: Patients with bullous disorders during COVID‐19 period: management and adherence to treatment date: 2020-05-26 words: 560 flesch: 34 summary: It mainly occurs in elderly patients that usually present other comorbidities such as cardiovascular and respiratory problems. key: cord-297532-ktiwfcop authors: De Fata Salvatores, Gaia; Villani, Alessia; Fabbrocini, Gabriella; Di Guida, Adriana title: Patients with bullous disorders during COVID‐19 period: management and adherence to treatment date: 2020-05-26 journal: Dermatol Ther DOI: 10.1111/dth.13697 sha: doc_id: keywords: covid-19; patients cache: cord-297532-ktiwfcop.txt plain text: cord-297532-ktiwfcop.txt item: #1607 of 2876 id: cord-297638-ab70s980 author: Stephens, Angela J. title: General Guidelines in the Management of an Obstetrical Patient on the Labor and Delivery Unit during the COVID-19 Pandemic date: 2020-04-28 words: 4538 flesch: 36 summary: However, there remains no evidence that NSAIDs worsen disease outcomes in COVID-19 patients. For these individuals, the risk/benefit ratio for ACS would suggest the benefits do not seem to outweigh the risks of facilitating or worsening COVID-19 infection. keywords: covid-19; delivery; health; infection; labor; patients; respiratory; trial; weeks; women cache: cord-297638-ab70s980.txt plain text: cord-297638-ab70s980.txt item: #1608 of 2876 id: cord-297759-arg71du6 author: Triantafyllou, Tania title: Esophageal cancer: challenges, concerns, and recommendations for management amidst the COVID-19 pandemic date: 2020-06-22 words: 3745 flesch: 24 summary: Cancer patients, and more precisely, immunocompromised patients, may be susceptible to severe illness with potentially fatal consequences [6] . However, existing data on the association between cancer and COVID-19 remain insufficient because of the small numbers of cancer patients that have been investigated, mainly in Eastern countries. keywords: cancer; covid-19; esophageal; pandemic; patients; risk; surgery; therapy; treatment cache: cord-297759-arg71du6.txt plain text: cord-297759-arg71du6.txt item: #1609 of 2876 id: cord-297832-picpuzvo author: Salazar, Rafael title: Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation date: 2020-10-06 words: 1775 flesch: 39 summary: A consensus for acute bronchospasm associated with SARS-CoV-2 infection is the use of mechanical ventilation [8] ; however, Zareifopoulos warns of the lack of evidence about the long-term benefits in patients on IMV [4] . To improve ventilatory mechanics and ultimately postpone the need for IMV due to acute bronchospasm in patients diagnosed with COVID-19, we put in place a therapeutic approach consisting of early respiratory therapy and pharmacological bronchospasm rescue approach. keywords: bronchospasm; covid-19; patients; score cache: cord-297832-picpuzvo.txt plain text: cord-297832-picpuzvo.txt item: #1610 of 2876 id: cord-297836-y9vt6wvu author: Tan, Yi Quan title: Re: Kristian D. Stensland, Todd M. Morgan, Alireza Moinzadeh, et al. Considerations in the Triage of Urologic Surgeries During the COVID-19 Pandemic. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2020.03.027: The Forgotten Urological Patient During the COVID-19 Pandemic: Patient Safety Safeguards date: 2020-05-08 words: 772 flesch: 39 summary: Patient safety is defined as the avoidance, prevention, and amelioration of adverse outcomes or injuries stemming from the processes of healthcare [3] . Amid the reduction of manpower and resources, patient safety may be compromised by deviations away from standard safety protocols because of fatigue or mental lapses, with J o u r n a l P r e -p r o o f disastrous consequences. keywords: covid-19; pandemic; patients cache: cord-297836-y9vt6wvu.txt plain text: cord-297836-y9vt6wvu.txt item: #1611 of 2876 id: cord-297840-z5l6vdsr author: Río, Francisco García title: Air Travel and Respiratory Disease date: 2007-02-28 words: 16168 flesch: 49 summary: Grupo Aula Médica Hypoxaemia during air travel in patients with chronic obstructive pulmonary disease Altitude exposures during aircraft flights: flying higher Oxygen concentrations in commercial aircraft flights Air travel and oxygen therapy in cardiopulmonary patients Air travel hypoxemia with chronic obstructive pulmonary disease Servera Pieras E. El pulmón y los viajes en avión Oxygen supplementation for chronic obstructive pulmonary disease patients during air travel Hypoxaemia in chronic obstructive pulmonary disease patients during a commercial flight Philadelphia: WB Saunders Company Air medical transport of cardiac patients Inflight arterial saturation: continuous monitoring by pulse oximetry Applied Respiratory Physiology Detection and correction of hypoxemia associated with air travel Altitude hypoxaemia and the arterial-toalveolar oxygen ratio Hypoxemia during air travel Changes in cardiac output during air ambulance repatriation Ventilation-perfusion inequality in normal humans during exercise at sea level and simulated altitude Limits of human lung function at high altitude Predicted gas exchange on the summit of Mt High altitude medicine and physiology. In other patients, in-flight hypoxemia should be estimated if they have a PaO 2 less than 70 mm keywords: air; air travel; aircraft; altitude; cabin; case; disease; flight; gas; health; hypoxia; level; medical; oxygen; pao; passengers; patients; pressure; pulmonary; risk; travel; use cache: cord-297840-z5l6vdsr.txt plain text: cord-297840-z5l6vdsr.txt item: #1612 of 2876 id: cord-297870-m7n43k4p author: Azevedo, Rafael Bellotti title: Covid-19 and the cardiovascular system: a comprehensive review date: 2020-07-27 words: 5113 flesch: 27 summary: Hence, the presence of heart disease is an important risk factor regarding the prognosis of COVID-19 patients evolving with acute myocardial injury The pathophysiology regarding myocardial damage caused by COVID-19 infection is not completely elucidated. keywords: ace2; cardiac; cov-2; covid-19; disease; hypertension; infection; injury; patients; risk; sars cache: cord-297870-m7n43k4p.txt plain text: cord-297870-m7n43k4p.txt item: #1613 of 2876 id: cord-298034-0ntxm28a author: Tepper, Joel E. title: Ethical Issues in Radiation Oncology During a Pandemic date: 2020-05-22 words: 1416 flesch: 47 summary: We need to consider not just the impact of radiation therapy on that patient, but also the impact on other patients, health care workers, and society at large. In addition, and as important, having additional patients in the department increases the risk of infecting other patients and their family members, and of infecting health care personnel. keywords: patient; situations; therapy cache: cord-298034-0ntxm28a.txt plain text: cord-298034-0ntxm28a.txt item: #1614 of 2876 id: cord-298056-svwtfshi author: Fabio, Ciceri title: Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy date: 2020-06-12 words: 3321 flesch: 37 summary: We identified J o u r n a l P r e -p r o o f Director-General's opening remarks at the media briefing on COVID-19 The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study Novel Coronavirus(2019-nCoV) Situation Report -11 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Clinical Characteristics of Coronavirus Disease 2019 in China Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Body composition phenotypes in pathways to obesity and the metabolic syndrome ARDS in Obese Patients: Specificities and Management Acute respiratory distress syndrome Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region Clinical and virological data of the first cases of COVID-19 in Europe: a case series Fast reshaping of intensive care unit facilities in a large metropolitan hospital in Milan, Italy: facing the COVID-19 pandemic emergency Fleischner Society: glossary of terms for thoracic imaging Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the The Novel Coronavirus Disease (COVID-19) Threat for Patients with Cardiovascular Disease and Cancer Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Functional exhaustion of antiviral lymphocytes in COVID-19 patients Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review The First Case of COVID-19 Treated With the Complement C3 Inhibitor AMY-101 The authors thank the entire staff of the San Raffaele Scientific Institute, working every day to ensure the best quality of care to patients and their families. In a large cohort of COVID-19 patients of European origin, main risk factors for mortality were older age, comorbidities, low lymphocyte count and high RALE. keywords: china; covid-19; data; disease; hospital; mortality; patients; risk; score cache: cord-298056-svwtfshi.txt plain text: cord-298056-svwtfshi.txt item: #1615 of 2876 id: cord-298067-awo3smgp author: Li, Huanjie title: Transmission Routes Analysis of SARS-CoV-2: A Systematic Review and Case Report date: 2020-07-10 words: 4863 flesch: 45 summary: Fecal transmission mode accounts for a small proportion of respiratory virus transmission. Summarizing the published articles, including SARS-CoV and SARS-CoV-2, we combined with epidemiological and clinical data to analyze the possible routes of asymptomatic patients with virus infection in order to provide the basis for suppressing the spread of the virus, and antiviral treatment and advice for the protection of medical staff. keywords: cases; cov-2; infection; patients; samples; sars; transmission; virus cache: cord-298067-awo3smgp.txt plain text: cord-298067-awo3smgp.txt item: #1616 of 2876 id: cord-298094-ctikhqvr author: Elias, Pierre title: The Prognostic Value of Electrocardiogram at Presentation to Emergency Department in Patients With COVID-19 date: 2020-08-15 words: 4172 flesch: 47 summary: 6 Electrocardiographic (ECG) abnormalities have been described but there have been no large studies of ECG abnormalities in COVID-19 patients nor their correlation with clinical outcomes. We propose that in the setting of triaging COVID-19 patients in the ED, ECG be treated as a sixth vital sign. keywords: abnormalities; covid-19; disease; ecg; patients; presentation cache: cord-298094-ctikhqvr.txt plain text: cord-298094-ctikhqvr.txt item: #1617 of 2876 id: cord-298325-2gm4fnqi author: Shah, Sonia title: Novel use of home pulse oximetry monitoring in COVID‐19 patients discharged from the emergency department identifies need for hospitalization date: 2020-06-17 words: 4002 flesch: 47 summary: All rights reserved Accepted Article Global Surveillance for human infection with coronavirus disease (COVID-19) Clinical progression of patients with COVID-19 in Shanghai A multicentre prospective observational study comparing arterial blood gas values to those obtained by pulse oximeters used in adult patients attending Australian and New Zealand hospitals Acute respiratory failure Relating oxygen partial pressure, saturation and content: the haemoglobin-oxygen dissociation curve Oxygen saturations less than 92% are associated with major adverse events in outpatients with pneumonia: a population-based cohort study Critical care crisis and some recommendations during the COVID-19 epidemic in China Pathological findings of COVID-19 associated with acute respiratory distress syndrome COVID-19 pneumonia: different respiratory treatments for different phenotypes? Evaluation and Treatment Coronavirus (COVID-19) Cytokine Storm in COVID-19 and Treatment Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan novel coronavirus (2019-nCoV) outbreak: A new challenge Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Rational use of personal protective equipment for coronavirus disease (COVID-19) and considerations during severe shortages Pulse oximetry: understanding its basic principles facilitates appreciation of its limitations Evaluating the accuracy of commercially available finger pulse oximeters in a hospital setting Risk factors for disease progression in hospitalized patients with COVID-19: a retrospective cohort study The importance of hypertension as a risk factor for severe illness and mortality in COVID-19 Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 -United States Risk factors for disease severity, unimprovement, and mortality in COVID-19 patients in Wuhan, China False-negative of RT-PCR and prolonged nucleic acid However, there are currently no data to guide the use of home pulse oximetry in COVID-19 patients or its validity in identifying disease progression. keywords: covid-19; home; patients; pulse; spo; study cache: cord-298325-2gm4fnqi.txt plain text: cord-298325-2gm4fnqi.txt item: #1618 of 2876 id: cord-298403-ilpzj2sv author: Mintz, Yoav title: Minimally Invasive Surgery is the Key to Patient and Operating room team Safety During the COVID19 Pandemic as well as in the “new normal” or chronic Pandemic State to come date: 2020-08-18 words: 747 flesch: 26 summary: Based on a review of the guidelines and recommendations with regard to the surgical approach (laparoscopy vs. laparotomy) as well as the literature regarding operations on COVID positive patients, we herein provide an educated pathway for the surgical approach for COVID-19 positive patients during the current pandemic and in the chronic pandemic state to come, highlighting the protection of OR teams until immunization becomes available. Obviously, however, emergent and oncological surgery for COVID-19 positive patients cannot always be postponed. keywords: laparoscopy; patients cache: cord-298403-ilpzj2sv.txt plain text: cord-298403-ilpzj2sv.txt item: #1619 of 2876 id: cord-298516-0eda4mzs author: Fadlallah, Ali title: LASIK procedures during COVID-19 date: 2020-08-05 words: 587 flesch: 47 summary: COVID-19 Guidelines for Triage of Ophthalmology Patients Steps Healthcare Facilities Can Take Now to Prepare for COVID-19 Social distancing was adopted by limiting the distance in the waiting room to 2 m between patients and by keeping a 20-minute interval between each patient admission. keywords: covid-19; patients; study cache: cord-298516-0eda4mzs.txt plain text: cord-298516-0eda4mzs.txt item: #1620 of 2876 id: cord-298679-w0yp4u19 author: Iftimie, Simona title: Risk factors associated with mortality in hospitalized patients with SARS-CoV-2 infection. A prospective, longitudinal, unicenter study in Reus, Spain date: 2020-09-03 words: 3589 flesch: 42 summary: Wuhan studies report that the incidence of cancer is higher in COVID-19 patients than in the general population [34, 35] . One aspect that caught our attention is that, despite our hospital being the reference center for Oncology in our province, the number of cancer patients infected with COVID-19 was relatively low. keywords: coronavirus; cov-2; covid-19; disease; mortality; patients; sars; study cache: cord-298679-w0yp4u19.txt plain text: cord-298679-w0yp4u19.txt item: #1621 of 2876 id: cord-298787-4vo9gpiu author: Frost, Holly M. title: Epidemiology and Clinical Presentation of Parainfluenza Type 4 in Children: A 3-Year Comparative Study to Parainfluenza Types 1–3 date: 2013-10-16 words: 3900 flesch: 48 summary: Human parainfluenza virus-associated hospitalizations among children less than five years of age in the United States Diagnosis and clinical significance of parainfluenza virus infections in children Hospitalized pediatric parainfluenza virus infections in a medical center Population-based surveillance for hospitalizations associated with respiratory syncytial virus, influenza virus, and parainfluenza viruses among young children Viral etiology of acute respiratory infections in hospitalized and outpatient children in Buenos Aires, Argentina Respiratory viruses in laryngeal croup of young children Human parainfluenza virus 4 outbreak and the role of diagnostic tests Epidemiology and clinical impact of parainfluenza virus infections in otherwise healthy infants and young children <5 years old Parainfluenza virus infection of young children: estimates of the population-based burden of hospitalization Detection and identification of human parainfluenza viruses 1, 2, 3, and 4 in clinical samples of pediatric patients by multiplex reverse transcription-PCR A prospective study of parainfluenza virus type 4 infections in children attending daycare Epidemiology and clinical presentation of the four human parainfluenza virus types Human parainfluenza virus type 4 infection in Chinese children with lower respiratory tract infections: a comparison study Infections due to parainfluenza virus type 4 in children Parainfluenza virus type 4: case report and review of the literature Human parainfluenza type 4 infections Research electronic data capture (REDCap)-a metadata-driven methodology and workflow process for providing translational research informatics support Seasonal trends of human parainfluenza viral infections: United States Relationship between five common viruses and febrile seizure in children Multicentered study of viral acute lower respiratory infections in children from four cities of Argentina, 1993-1994 Pediatric hospitalizations for croup (laryngotracheobronchitis): biennial increases associated with human parainfluenza virus 1 epidemics Strain variation in parainfluenza virus type 4 Parainfluenza virus type 3: seasonality and risk of infection and reinfection in young children Rapid viral diagnosis for acute febrile respiratory illness in children in the emergency department Diagnostic value of respiratory virus detection in symptomatic children using real-time PCR Diagnostic value of real-time polymerase chain reaction to detect viruses in young children admitted to the paediatric intensive care unit with lower respiratory tract infection Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial Detecting respiratory viruses in asymptomatic children Persistence of rhinovirus and enterovirus RNA after acute respiratory illness in children Heterogeneity in viral shedding among individuals with medically attended influenza A virus infection Financial support. Clinical presentation and severity of HPIV-4 infections most closely resembled those of HPIV-3 infections; however, HPIV-4 did not have the same predisposition for patients with underlying medical conditions as HPIV-3. HPIV-4 was the only HPIV type not associated with croup. keywords: children; hpiv-4; infections; parainfluenza; patients; respiratory; virus cache: cord-298787-4vo9gpiu.txt plain text: cord-298787-4vo9gpiu.txt item: #1622 of 2876 id: cord-298894-t5hyfum3 author: Rifino, Nicola title: Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, Italy date: 2020-10-07 words: 4694 flesch: 41 summary: Although soon after all Italian regions reported patients with COVID-19, the highest number of cases was in Eastern Lombardy [2] , specifically in the Bergamo's province with 11,313 confirmed COVID-19 patients up to April 30th 2020 Patients with peripheral nervous system involvement had more frequently severe ARDS compared to patients with cerebrovascular disease (87.1% vs 42%; difference = 45.1% 95% CI 42.0–48.2; χ(2)= 14.306; p < 0.0002) and with altered mental status (87.1% vs 55.6%; difference = 31.5% 95% CI 27.5–37.5%; χ(2)= 7.055; p < 0.01). keywords: acute; cases; cov-2; covid-19; csf; disease; infection; involvement; patients; sars; study cache: cord-298894-t5hyfum3.txt plain text: cord-298894-t5hyfum3.txt item: #1623 of 2876 id: cord-298967-vjyh1xvh author: Bertossi, Dario title: Safety guidelines for non‐surgical facial procedures during covid‐19 outbreak date: 2020-06-07 words: 2006 flesch: 45 summary: In our largely elective field, both staff and resources should ideally be allocated through careful protocols in order to prevent COVID-19 infection. In response to this pandemic, our focus group has developed a process to stratify procedures and clinical levels with protocols that aim to minimize the risk of contagion and the diffusion of COVID-19 infection. keywords: coronavirus; covid-19; guidelines; infection; patients; procedures; sars cache: cord-298967-vjyh1xvh.txt plain text: cord-298967-vjyh1xvh.txt item: #1624 of 2876 id: cord-298974-69xjc5yq author: Adegboye, Oyelola A. title: Network Analysis of MERS Coronavirus within Households, Communities, and Hospitals to Identify Most Centralized and Super-Spreading in the Arabian Peninsula, 2012 to 2016 date: 2018-05-07 words: 4312 flesch: 45 summary: Reducing contact formation especially within the hospital by restricting hospital visitation for MERS patient families and reducing the number of healthcare workers with access to MERS patients will certainly have significant effect on the spread of MERS disease. There were 1113 isolated cases while the number of recorded contacts per MERS patient is between 1 (n=210) and 17 (n=1), with a mean of 0.27 (SD = 0.76). keywords: cases; centrality; healthcare; hospital; infection; mers; network; nodes; patient cache: cord-298974-69xjc5yq.txt plain text: cord-298974-69xjc5yq.txt item: #1625 of 2876 id: cord-299024-jkqdzt87 author: Mangner, Norman title: Paraneoplastic syndrome and SARS-CoV-2 – incremental effect of two thrombogenic conditions? date: 2020-10-21 words: 1073 flesch: 31 summary: This case describes a patient with non-bacterial thrombotic aortic valve endocarditis that developed despite treatment with a factor-Xa-inhibitor and who subsequently suffered a myocardial infarction and two strokes within a short period of time in the context of a paraneoplastic syndrome and asymptomatic SARS-CoV-2 infection. Paraneoplastic syndromes are often linked to increased thrombogenicity; however, non-bacterial thrombotic aortic valve endocarditis is rare even in the situation of cancer. keywords: covid-19; infection; sars cache: cord-299024-jkqdzt87.txt plain text: cord-299024-jkqdzt87.txt item: #1626 of 2876 id: cord-299082-s8bm40vy author: Wang, Yueying title: Cardiac arrhythmias in patients with COVID‐19 date: 2020-07-26 words: 3724 flesch: 31 summary: An example of reversible electrical storm Incessant monomorphic ventricular tachycardia during febrile illness in a patient with Brugada syndrome: fatal electrical storm Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure Fever increases the risk for cardiac arrest in the Brugada syndrome Hyperthermia influences the effects of sodium channel blocking drugs in human-induced pluripotent stem cell-derived cardiomyocytes Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic Antihypertensive treatment with ACEI/ARB of patients with COVID-19 complicated by hypertension Angiotensin II and angiotensin 1-7: which is their role in atrial fibrillation? CaMKII as a target for arrhythmia suppression Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure Cardiac and arrhythmic complications in patients with COVID-19 Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias Acute regional left atrial ischemia causes acceleration of atrial drivers during atrial fibrillation Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro Electrophysiologic studies on the risks and potential mechanism underlying the proarrhythmic nature of azithromycin Azithromycin causes a novel proarrhythmic syndrome Toxicity of macrolide antibiotics on isolated heart mitochondria: a justification for their cardiotoxic adverse effect Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Multilead QT screening is necessary for QT measurement: implications for management of patients in the COVID-19 era Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin Expert recommendations for clinical management of myocardial injury associated with coronavirus disease Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies COVID-19) This is followed by a discussion on the underlying mechanisms, with proposals of preventative and therapeutic strategies for treating cardiac arrhythmias in COVID-19 patients. keywords: acute; arrhythmias; azithromycin; cardiac; clinical; coronavirus; covid-19; patients; sars; syndrome cache: cord-299082-s8bm40vy.txt plain text: cord-299082-s8bm40vy.txt item: #1627 of 2876 id: cord-299124-g70v4crs author: Lancaster, Elizabeth M. title: Impact of the COVID-19 pandemic on an academic vascular practice and a multi-disciplinary limb preservation program date: 2020-09-12 words: 2178 flesch: 37 summary: 9 Faculty, fellows, and residents provide care for vascular patients at the main UCSF campus as 10 well as two partner hospitals; the San Francisco Veteran Affairs (SFVA) Medical Center and 11 Zuckerberg San Francisco General Hospital (ZSFG, a safety net/community hospital). We did not experience an 19 inability to admit CLTI patients requiring hospital-level care during this period, nor was there a 20 lack of access to the operating room for high priority limb revascularization procedures. keywords: care; clti; limb; pandemic; patients; vascular cache: cord-299124-g70v4crs.txt plain text: cord-299124-g70v4crs.txt item: #1628 of 2876 id: cord-299156-1dwsm3ie author: Shemer, Asaf title: Ocular involvement in coronavirus disease 2019 (COVID-19): a clinical and molecular analysis date: 2020-09-14 words: 3521 flesch: 52 summary: It should also be noted that when COVID-19 patients were questioned on redness or discharge in the 30 days prior to admission, five (Patients #2, #3 and three additional patients) responded positively (compared to none in the control group, p = 0.001, Table 3 ). COVID-19 patients were clinically categorized to mild, moderate or severe on a daily basis according to a risk assessment calculated using the Modified Early Warning Score (MEWS) keywords: conjunctival; cov-2; covid-19; disease; patients; sars cache: cord-299156-1dwsm3ie.txt plain text: cord-299156-1dwsm3ie.txt item: #1629 of 2876 id: cord-299222-vmofcrim author: Rivas‐Pollmar, María Isabel title: Thromboprophylaxis in a patient with COVID‐19 and severe hemophilia A on emicizumab prophylaxis date: 2020-06-11 words: 1575 flesch: 32 summary: Blood Emicizumab Prophylaxis in Patients Who Have Hemophilia A without Inhibitors Emicizumab Prophylaxis in Hemophilia A with Inhibitors Accepted Article 176 Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19 SARS-CoV-2 and viral sepsis: observations and hypotheses Incidence of thrombotic complications in critically ill ICU patients with COVID-19 High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Monitoring low molecular weight heparins at therapeutic levels: dose-responses of, and correlations and differences between aPTT, anti-factor Xa and thrombin generation assays VJY were responsable for the clinical management of the patient, SGB was the nurse who administered the treatment, and NBC was responsible for the laboratory tests. This mild and favourable course of our patient with SHA on emicizumab prophylaxis could be interpreted in the same way as for around 85% of COVID-19 patients, i.e. neither the hemophilia nor the emicizumab treatment has a significant influence on the course of the disease, or that, however SHA and/or emicizumab and/or HIV status has any protective effect against inflammation and immunothrombosis per se. keywords: covid-19; emicizumab; patients; prophylaxis cache: cord-299222-vmofcrim.txt plain text: cord-299222-vmofcrim.txt item: #1630 of 2876 id: cord-299254-kqpnwkg5 author: Sun, Yingcheng title: INSMA: An integrated system for multimodal data acquisition and analysis in the intensive care unit date: 2020-04-28 words: 4610 flesch: 36 summary: The prototype system has been tested using ICU patient data from ECG to understand how variability in the heartbeat time-series can be used to dynamically track patient state [19] . All three modules are developed using MFC and C/C++, so that they all run in the same operating environment and use compatible data formats, and therefore provide a complete solution for data acquisition, parsing and visualization. keywords: acquisition; analysis; care; data; icu; information; insma; monitor; patient; system; time; visualization cache: cord-299254-kqpnwkg5.txt plain text: cord-299254-kqpnwkg5.txt item: #1631 of 2876 id: cord-299333-qu0bmov5 author: Reddy, Gireesh B. title: Clinical Characteristics and Multisystem Imaging Findings of COVID-19: An Overview for Orthopedic Surgeons date: 2020-08-17 words: 4421 flesch: 28 summary: The most common abdominal imaging findings in COVID-19 ICU patients include small and large bowel wall thickening, non-enhancing bowel, pneumatosis, portal venous gas, and bowel perforation, all related to bowel and mesenteric ischemia, infarction, and necrosis ( Fig. 14) In addition to the widely known pulmonary symptoms, COVID-19 patients may initially present with atypical neurologic, gastrointestinal, cardiac, and musculoskeletal imaging findings (Table 1) , which are more likely to be undiagnosed. keywords: acute; coronavirus; covid-19; disease; findings; imaging; manifestations; patients; pulmonary; symptoms; syndrome cache: cord-299333-qu0bmov5.txt plain text: cord-299333-qu0bmov5.txt item: #1632 of 2876 id: cord-299346-f13xly6q author: Awad, Mohamed E. title: Perioperative Considerations in Urgent Surgical Care of Suspected and Confirmed Coronavirus Disease 2019 Orthopaedic Patients: Operating Room Protocols and Recommendations in the Current Coronavirus Disease 2019 Pandemic date: 2020-04-10 words: 4218 flesch: 35 summary: Our recommendations for using face masks and respirators varies depending on the setting and activity ( ½T1 Table 1 Of note, the regular surgical helmet cannot replace the need of respirator while operating on suspected/ confirmed COVID-19 patients. [15] A recent study investigating SARS-CoV-2 from clinical specimens found that RNA virus detected in blood samples from confirmed COVID-19 patients (3 of 307; 1%). keywords: care; contamination; coronavirus; covid-19; disease; face; pandemic; patients; ppe; risk; use cache: cord-299346-f13xly6q.txt plain text: cord-299346-f13xly6q.txt item: #1633 of 2876 id: cord-299449-226dd23u author: Bernhardt, Denise title: Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas date: 2020-05-05 words: 4203 flesch: 34 summary: Results of a phase II study Short Course versus Standard Course of Radiotherapy in Glioblastoma Multiforme Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Gene Silencing and Benefit From Temozolomide in Glioblastoma Central nervous system cancers, version 1.2017 featured updates to the NCCN guidelines Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised Pulmonary Toxicity of Cytotoxic and Immunosuppressive Agents: A Review Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma Maintenance therapy with tumor-Treating fields plus temozolomide vs temozolomide alone for glioblastoma a randomized clinical trial Dexamethasone in glioblastoma multiforme therapy: Mechanisms and controversies Clinical evidence does not support corticosteroid treatment for This practice recommendation presents a pragmatic framework and consensus-based mitigation strategies for the treatment of HGG patients during the SARS-CoV-2 pandemic. keywords: c r; cov-2; p t; pandemic; patients; sars; treatment cache: cord-299449-226dd23u.txt plain text: cord-299449-226dd23u.txt item: #1634 of 2876 id: cord-299489-6v225vte author: Gómez-Hernández, María Teresa title: TWICE LUCKY: ELDERLY PATIENT SURVIVING BOTH COVID-19 AND SERENDIPITOUS LUNG CARCINOMA date: 2020-07-25 words: 506 flesch: 37 summary: Besides, since it is imperative to ensure the safety of health-care workers not only to safeguard continuous patient care but also to ensure they do not transmit the virus, high-sensibility diagnostic tests should be routinely performed to identify current and past infection (serologic tests) and to ensure that patients who have overcome the disease are no longer contagious (nucleic acid tests). 19 is associated with poor prognosis for patients undergoing thoracic operation, especially for those with COPD. keywords: covid-19; patient cache: cord-299489-6v225vte.txt plain text: cord-299489-6v225vte.txt item: #1635 of 2876 id: cord-299570-1xz5r95f author: Martínez-García, M title: Telemedicina con telemonitorización en el seguimiento de pacientes con COVID-19 date: 2020-06-05 words: 1611 flesch: 50 summary: Sanitaria de Lugo entre el 17 de marzo y el 17 de abril de 2020. Entendemos que este sistema ha contribuido a que el flujo de pacientes fuese ordenado y a que las visitas espontáneas a Urgencias hayan sido la excepción. keywords: con; covid-19; los; pacientes; patients; que; seguimiento cache: cord-299570-1xz5r95f.txt plain text: cord-299570-1xz5r95f.txt item: #1636 of 2876 id: cord-299621-m4kdkmey author: Kumar, A. title: Outbreak of Middle East respiratory syndrome coronavirus, Saudi Arabian experience date: 2017-08-31 words: 1871 flesch: 36 summary: Hospital outbreak of Middle East respiratory syndromecoronavirus Coronavirus: diagnostics epidemiology and transmission None. In addition, portable HEPA filter machines (8) were procured to be used in respiratory illness rooms identified at high risk patient care locations viz: haemodialysis unit, Outpatient services, Special care baby unit, Paediatric services, Obstetric and Internal Medicine wards. keywords: cov; hospital; infection; mers; patients; respiratory cache: cord-299621-m4kdkmey.txt plain text: cord-299621-m4kdkmey.txt item: #1637 of 2876 id: cord-299679-6z9e5gi6 author: Rello, Jordi title: Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers date: 2020-05-21 words: 1965 flesch: 34 summary: The facts during the third epidemic Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Coagulopathy and antiphospholipid antibodies in patients with covid-19 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease in patients with coagulopathy Endemic human coronaviruses in hospitalized adults with community-acquired pneumonia: results from the Louisville Pneumonia Study Towards precision medicine in sepsis: a position paper from the European Society of Clinical Microbiology and Infectious Diseases Coronavirus disease 2019 (COVID-19): a critical care perspective beyond China Utility of point-of-care lung ultrasound for initial assessment of acute respiratory distress syndrome patients in the emergency department COVID-19 pneumonia different respiratory treatment for different phenotypes? Testing for respiratory viruses in adults with severe lower respiratory infections Clinical and CT features in pediatric patients with COVID-19 infection: different points from adults Severe 2009 A/H1N1v influenza in pregnant women in Spain Coronaviruses and immunosuppressed patients. keywords: acute; hypoxaemia; lung; patients; phenotype; sars cache: cord-299679-6z9e5gi6.txt plain text: cord-299679-6z9e5gi6.txt item: #1638 of 2876 id: cord-299681-smhto9em author: Elsaie, Mohamed L. title: Herpes zoster might be an indicator for Latent COVID 19 infection date: 2020-05-23 words: 693 flesch: 44 summary: Patients: A Review Herpes Zoster-Typical and atypical presentations Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis Epub ahead of print Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Clinical Features of COVID-19 and Factors Associated with Severe Clinical Course: A Systematic Review and Meta-Analysis Epub ahead of print COVID-19: immunopathology and its implications for therapy Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Functional exhaustion of antiviral lymphocytes in COVID-19 patients Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients key: cord-299681-smhto9em authors: Elsaie, Mohamed L.; Youssef, Eman A.; Nada, Hesham A. title: Herpes zoster might be an indicator for Latent COVID 19 infection date: 2020-05-23 journal: Dermatol Ther DOI: 10.1111/dth.13666 sha: doc_id: 299681 cord_uid: smhto9em Various cutaneous manifestations have been observed in patients with COVID‐19 infection. keywords: covid-19; infection; patients cache: cord-299681-smhto9em.txt plain text: cord-299681-smhto9em.txt item: #1639 of 2876 id: cord-299750-zkrlm3ds author: Cui, Wei title: Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China date: 2010-05-31 words: 4967 flesch: 47 summary: Persons aged 50 years or older showed a low incidence of 2009 H1N1 influenza infection, this may be due to protection by preexisting immunity resulting from previous exposure to H1N1 influenza infection, along with reduced outdoor activity by these individuals because of the fear of H1N1 infection. In our study, almost 80% of the hospitalizations due to H1N1 influenza infection involved individuals who were between the ages of 18 and 49 years. keywords: days; h1n1; illness; infection; influenza; pandemic; patients; study; virus cache: cord-299750-zkrlm3ds.txt plain text: cord-299750-zkrlm3ds.txt item: #1640 of 2876 id: cord-299784-xxxdjfbc author: Bettari, Luca title: Exploring Personal Protection During High-Risk PCI in a COVID-19 Patient: Impella CP Mechanical Support During ULMCA Bifurcation Stenting date: 2020-04-10 words: 749 flesch: 35 summary: Guidance for Wearing and Removing Personal Protective Equipment in Healthcare Settings for the Care of Patients With Suspected or Confirmed COVID Chewed ticagrelor tablets provide faster platelet inhibition compared to integral tablets: the inhibition of platelet aggregation after administration of three different ticagrelor formulations (IPAAD-Tica) study, a randomised controlled trial Antibacterial activity of ticagrelor in conventional antiplatelet dosages against antibiotic-resistant gram-positive bacteria Coronavirus disease 2019 and influenza Hemodynamics and its predictors during Impellaprotected PCI in high risk patients with reduced ejection fraction Realworld use of the Impella 2.5 circulatory support system in complex high-risk percutaneous coronary intervention: the USpella Registry Supported high-risk percutaneous coronary intervention with the Impella 2.5 device the Europella registry Catheterization laboratory considerations during the coronavirus (COVID-19) pandemic: from ACC's Interventional Council and SCAI KEY WORDS COVID-19, high-risk PCI, personal protection equipment APPENDIX We report the first case of a patient with COVID-19 and acute coronary syndromes treated in Italy for unprotected LMCA stenosis with protected percutaneous coronary intervention. keywords: impella; patient; risk cache: cord-299784-xxxdjfbc.txt plain text: cord-299784-xxxdjfbc.txt item: #1641 of 2876 id: cord-299835-92karhpl author: Ho, Khek Y. title: Mild Illness Associated with Severe Acute Respiratory Syndrome Coronavirus Infection: Lessons from a Prospective Seroepidemiologic Study of Health-Care Workers in a Teaching Hospital in Singapore date: 2004-02-17 words: 3528 flesch: 48 summary: The present study is the first to document SARS infection in HCWs with normal chest radiographs. The second important finding we observed is that individuals who did not have direct contact with patients with SARS also both developed clinical SARS and experienced seroconversion with milder illness. keywords: contact; hcws; hospital; patients; samples; sars; syndrome cache: cord-299835-92karhpl.txt plain text: cord-299835-92karhpl.txt item: #1642 of 2876 id: cord-299881-weptfpa2 author: Halvachizadeh, Sascha title: The impact of SARS-CoV-2 (COVID-19) pandemic on trauma bay management and guideline adherence in a European level-one-trauma centre date: 2020-07-28 words: 3334 flesch: 41 summary: It is assumed that admission rates of trauma patients have been influenced by patients avoiding trauma submissions. Transportation of trauma patients through the hospital should be avoided. keywords: bay; covid-19; data; group; number; pandemic; patients; study; trauma cache: cord-299881-weptfpa2.txt plain text: cord-299881-weptfpa2.txt item: #1643 of 2876 id: cord-300038-1fjb6b8e author: Cantini, Fabrizio title: Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact date: 2020-04-23 words: 1264 flesch: 41 summary: On this basis, we assessed the safety of baricitinib therapy combined with lopinavir-ritonavir in moderate COVID-19 pneumonia patients and we evaluated its clinical impact. These results were likely due to the rapid action of the drug and the short median interval of 6 days from symptoms-onset and therapy starting, The major limitations of this pilot study were its open-label design with no randomization and the low number of treated patients. keywords: baricitinib; covid-19; patients; therapy; treatment cache: cord-300038-1fjb6b8e.txt plain text: cord-300038-1fjb6b8e.txt item: #1644 of 2876 id: cord-300044-vn4c6wh7 author: Kim, Ji Won title: From White Count to White Out() date: 2015-08-05 words: 2856 flesch: 40 summary: Viral bronchiolitis typically presents with upper respiratory symptoms followed by lower respiratory infection resulting in wheezing and rales in children younger than two years of age. Within 12 hours of admission, he was transferred to the pediatric intensive care unit for worsening respiratory distress. keywords: chest; diagnosis; hyper; hypoxia; igm; patients; pneumonia; syndrome cache: cord-300044-vn4c6wh7.txt plain text: cord-300044-vn4c6wh7.txt item: #1645 of 2876 id: cord-300080-l0fyxtva author: Venkat, Arvind title: Ethical Issues in the Response to Ebola Virus Disease in US Emergency Departments: A Position Paper of the American College of Emergency Physicians, the Emergency Nurses Association and the Society for Academic Emergency Medicine date: 2015-03-10 words: 8371 flesch: 37 summary: Another ethical consideration is the reputational impact upon hospitals caring for Ebola patients. It is therefore imperative, in the face of a disease such as Ebola that has generated such public scrutiny and at times hysteria, for hospitals to be cognizant of their ethical responsibility to support the efforts of designated treatment centers as well as frontline facilities that might encounter Ebola patients and potentially be perceived adversely by the public. keywords: care; disease; duty; ebola; emergency; emergency departments; emergency nurses; emergency physicians; evd; healthcare; outbreak; patients cache: cord-300080-l0fyxtva.txt plain text: cord-300080-l0fyxtva.txt item: #1646 of 2876 id: cord-300183-z3fwtwqb author: Ahmed, Taha title: Community and healthcare system-related factors feeding the phenomenon of evading medical attention for time-dependent emergencies during COVID-19 crisis date: 2020-08-25 words: 3449 flesch: 44 summary: The data from various countries of Europe show a 25%-40% drop in STEMI presentations and admissions as compared with during the peak of pandemic. [8] [9] [10] In the USA, a comparable decrease in STEMI presentations is reported in different states irrespective of the state's burden of COVID-19. keywords: care; complications; covid-19; healthcare; infarction; pandemic; patient; presentation; stemi cache: cord-300183-z3fwtwqb.txt plain text: cord-300183-z3fwtwqb.txt item: #1647 of 2876 id: cord-300303-d4qmtysd author: de Azambuja, Evandro title: ESMO Management and treatment adapted recommendations in the COVID-19 era: Breast Cancer date: 2020-05-20 words: 6990 flesch: 25 summary: CC declares consultancy/advisory role/speaker's bureau: Pfizer Cancer guidelines during the COVID-19 pandemic Fair allocation of scarce medical resources in the time of Covid-19 Impact of nonpharmaceutical interventions (NPIs) to reduce COVID-19 mortality and healthcare demand Essential care of critical illness must not be forgotten in the COVID-19 pandemic Measuring performance on the healthcare access and quality index for 195 countries and territories and selected subnational locations: a systematic analysis from the global burden of disease study 2016 Cancer, COVID-19 and the precautionary principle: prioritizing treatment during a global pandemic Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China COVID-19: operational guidance for maintaining essential health services during an outbreak interim guidance Identify priority problems and goals to improve the model of care ESMO-Magnitude of clinical benefit scale version 1.1 Contributing to a global effort Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13 722 women Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data The financial burden and distress of patients with cancer: understanding and stepping-up action on the financial toxicity of cancer treatment Delay in breast cancer: implications for stage at diagnosis and survival Prognosis after ipsilateral breast tumor recurrence and locoregional recurrences in patients treated by breast-conserving therapy in five national surgical adjuvant breast and bowel project protocols of node-negative breast cancer Adjuvant therapy after excision and radiation of isolated postmastectomy locoregional breast cancer recurrence: definitive results of a phase III randomized trial (SAKK 23/82) comparing tamoxifen with observation Efficacy of chemotherapy for ER-negative and ER-positive isolated locoregional recurrence of breast cancer: final analysis of the CALOR trial Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations Risk score for drugassociated QTc prolongation. While the score has been applied to a several novel compounds for breast cancer treatment, mostly in the advanced setting, less scoring has been performed in the early breast cancer setting, particularly with chemotherapy regimens, and this should be considered when balancing risk and benefits. keywords: breast; breast cancer; cancer; care; clinical; covid-19; health; healthcare; interventions; oncology; pandemic; patients; priority; setting; treatment cache: cord-300303-d4qmtysd.txt plain text: cord-300303-d4qmtysd.txt item: #1648 of 2876 id: cord-300344-57vxlctl author: Roof, Kevin S. title: Virtual On Treatment Visits: Implementation, Patient Perspectives, Barriers, Limitations, Benefits and Opportunities. date: 2020-10-16 words: 4339 flesch: 49 summary: On March 30, 2020, CMS authorized use of telemedicine for management of radiation oncology patients under treatment (2) . However we believe this is the first report on the use of telemedicine for radiation oncology patient under treatment visits. keywords: centers; patients; person; physician; question; radiation; visits; votvs cache: cord-300344-57vxlctl.txt plain text: cord-300344-57vxlctl.txt item: #1649 of 2876 id: cord-300356-oorac5he author: Nair, Girish B. title: Community-Acquired Pneumonia: An Unfinished Battle date: 2011-10-05 words: 7388 flesch: 35 summary: Eur Respir Severe community-acquired pneumonia: validation of the Infectious Diseases Society of America/American Thoracic Society guidelines to predict an intensive care unit admission Validation of the Infectious Disease Society of America/American Thoracic Society 2007 guidelines for severe community-acquired pneumonia PIRO score for community-acquired pneumonia: a new prediction rule for assessment of severity in intensive care unit patients with community-acquired pneumonia SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia Quality of care, process, and outcomes in elderly patients with pneumonia Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia Comparison of levofloxacin and cefotaxime combined with ofloxacin for ICU patients with community-acquired pneumonia who do not require vasopressors Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock Early switch from intravenous to oral antibiotics in hospitalized patients with bacteremic community-acquired Streptococcus pneumoniae pneumonia Predicting bacteremia in patients with community-acquired pneumonia Rapid diagnosis of bacteremic pneumococcal infections in adults by using the Binax NOW Streptococcus pneumoniae urinary antigen test: a prospective, controlled clinical evaluation Utility of a pneumonia severity index in the optimization of the diagnostic and therapeutic effort for community-acquired pneumonia Trends in legionnaire's disease, 1980-1998: declining mortality and new patterns of diagnosis Current and potential usefulness of pneumococcal urinary antigen detection in hospitalized patients with community-acquired pneumonia to guide antimicrobial therapy Cardiovascular and inflammatory biomarkers to predict short-and long-term survival in community-acquired pneumonia: results from the German Competence Network, CAPNETZ Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia Procalcitonin-Guided Antibiotic Therapy and Hospitalisation in Patients with Lower Respiratory Tract Infections (ProHOSP) Study Group. keywords: antibiotic; cap; community; disease; factors; icu; illness; infection; mortality; patients; pneumonia; respiratory; risk; therapy cache: cord-300356-oorac5he.txt plain text: cord-300356-oorac5he.txt item: #1650 of 2876 id: cord-300445-qzu4gz2d author: Zhang, Xiao-lei title: Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives date: 2020-09-23 words: 7259 flesch: 34 summary: Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients. Later, under a limited emergency-use authorization from the FDA, hydroxychloroquine in combination with azithromycin was used to treat COVID-19 patients in the USA, although the mechanisms of the anti-COVID-19 effects remain unclear. keywords: azithromycin; cardiac; cardiovascular; chloroquine; cov-2; covid-19; disease; effects; hydroxychloroquine; infection; injury; patients; risk; sars; treatment cache: cord-300445-qzu4gz2d.txt plain text: cord-300445-qzu4gz2d.txt item: #1651 of 2876 id: cord-300458-jeuwaj50 author: Maisch, Bernhard title: COVID-19—What we know and what we need to know: There are more questions than answers date: 2020-04-23 words: 1160 flesch: 50 summary: key: cord-300458-jeuwaj50 authors: Maisch, Bernhard; Dörr, Rolf title: COVID-19—What we know and what we need to know: There are more questions than answers date: 2020-04-23 journal: Herz DOI: 10.1007/s00059-020-04929-9 sha: doc_id: 300458 cord_uid: jeuwaj50 nan COVID-19-What we know and what we need to know: There are more questions than answers This collection of short statements from the editors of HERZ/ The electrophysiologists have regularly observed an increase of arrhythmias in myocarditis patients, but it is unclear whether this also holds for ventricular tachycardias in overt cardiac inflammation, which might be cytokine driven. keywords: covid-19; pandemic; patients; virus cache: cord-300458-jeuwaj50.txt plain text: cord-300458-jeuwaj50.txt item: #1652 of 2876 id: cord-300510-fhpkdqr0 author: Mojoli, Francesco title: Our recommendations for acute management of COVID-19 date: 2020-05-08 words: 1085 flesch: 32 summary: Rapid response to COVID-19 outbreak in Northern Italy: how to convert a classic infectious disease ward into a COVID-19 response centre Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial Critical care management of adults with community-acquired severe respiratory viral infection Clinical management of severe acute respiratory infection when Novel coronavirus (2019-nCoV) infection is suspected: Interim Guidance 28 Esophageal and transpulmonary pressure in the clinical setting: meaning, usefulness and perspectives Lung ultrasound for critically ill patients Assessment of lung aeration and recruitment by CT scan and ultrasound in acute respiratory distress syndrome patients Lung ultrasound for early diagnosis of ventilator-associated pneumonia Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Thrombotic events in SARS-Cov 2 patients: an urgent call for ultrasound screening Setup of a dedicated coronavirus intensive care unit: logistical aspects Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations 7. Perform early intubation if poor response to continuous positive airway pressure in terms of oxygenation: do not trust patients' relatively good respiratory mechanics and feeling of improved dyspnoea, since these patients may have relatively normal lung compliance and the only clinical sign of fatigue may be high respiratory rate. keywords: care; coronavirus; lung; patients; pressure cache: cord-300510-fhpkdqr0.txt plain text: cord-300510-fhpkdqr0.txt item: #1653 of 2876 id: cord-300559-vuuxthx2 author: Deng, Ming title: Obesity as a Potential Predictor of Disease Severity in Young COVID‐19 Patients: A Retrospective Study date: 2020-06-29 words: 4170 flesch: 49 summary: [34, 35] , and the risk of thrombosis is high for severe COVID-19 patients Logistic regression analysis showed that male, high body mass index (especially obesity), elevated fasting blood glucose and urinary protein positive are all risk factors for severe young COVID‐19 patients. keywords: albumin; article; cases; copyright; covid-19; liver; obesity; patients; study cache: cord-300559-vuuxthx2.txt plain text: cord-300559-vuuxthx2.txt item: #1654 of 2876 id: cord-300608-eju7wnb9 author: Sheervalilou, Roghayeh title: COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease date: 2020-05-26 words: 7424 flesch: 38 summary: The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: Implication for infection prevention and control measures Updates on Wuhan 2019 novel coronavirus epidemic Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: Involvement of p38 MAPK and ERK Prevalence and risk factors for posttraumatic stress disorder: A cross-sectional study among survivors of the Wenchuan Dipeptidylpeptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV Positive RT-PCR test results in patients recovered from COVID-19 Sex differences in clinical findings among patients with coronavirus disease 2019 (COVID-19) and severe condition Early transmission dynamics in Wuhan, China, of novel coronavirusinfected pneumonia Hypokalemia and clinical implications in patients with coronavirus disease 2019 (COVID-19) Case of the index patient who caused tertiary transmission of Coronavirus disease 2019 in Korea: The application of lopinavir/ ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR Therapeutic effects of dipyridamole on COVID-19 patients with coagulation dysfunction The reproductive number of COVID-19 is higher compared to SARS coronavirus Molecular epidemiology, evolution and phylogeny of SARS coronavirus Application of artificial neural networks for automated analysis of cystoscopic images: 5.3 | COVID-19 detection tests: Pathogenic laboratory testing, real-time RT-PCR, and sequencing of nucleic acid Table 3 (Ai et al., 2020; Bai et al., 2020; Chen, Zhao, et al., 2020; Shi et al., 2020; Tian et al., 2020; Wang, Kang, et al., 2020; Wu & McGoogan, 2020; Yan et al., 2020; Yang et al., 2020) and Table 4 represent 2020 studies on diagnosis of COVID-19 infected patients and related clinical trials, respectively. keywords: cases; china; clinical; coronavirus; cov-2; covid-19; diagnosis; disease; et al; human; infection; novel; patients; pneumonia; sars; study; treatment cache: cord-300608-eju7wnb9.txt plain text: cord-300608-eju7wnb9.txt item: #1655 of 2876 id: cord-300697-p96i25uc author: Chen, Taojiang title: A severe coronavirus disease 2019 patient with high-risk predisposing factors died from massive gastrointestinal bleeding: a case report date: 2020-09-29 words: 2189 flesch: 37 summary: Endoscopy Gastrointestinal Bleeding in Patients with Severe SARS-CoV-2 Novel Insights Into Illness Progression and Risk Profiles for Mortality in Non-survivors of COVID-19 SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease Disease Control and Prevention Bureau of National Health and Health Commission: Guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (Trial Version 7) (in Chinese) Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patient with COVID-19 High-dose intravenous immunoglobulin as a therapeutic option for deteriorating patients with coronavirus disease 2019 Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective Digestive system involvement of novel coronavirus infection: prevention and control infection from a gastroenterology perspective Hypothesis: Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19 Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Not applicable. We aimed to share some experience for prevention of disease progression in COVID-19 patients with defined risk factors, in order to improve the outcomes in such patients. keywords: covid-19; disease; infection; patient; risk; sars cache: cord-300697-p96i25uc.txt plain text: cord-300697-p96i25uc.txt item: #1656 of 2876 id: cord-300774-5mrkmctl author: Hernández-Mora, Miguel Górgolas title: Compassionate Use of Tocilizumab in Severe SARS-CoV2 Pneumonia date: 2020-10-25 words: 4339 flesch: 42 summary: We provided tocilizumab on a compassionate-use basis to patients with SSP hospitalized (excluding intensive care and intubated cases) who required oxygen support to have a saturation >93%. Patients received at least one dose of 400 mg intravenous tocilizumab during March 8-2020, through April 20-2020. keywords: administration; cases; covid-19; oxygen; patients; study; support; tcz; tocilizumab; treatment cache: cord-300774-5mrkmctl.txt plain text: cord-300774-5mrkmctl.txt item: #1657 of 2876 id: cord-300811-l4y7df2f author: Aggarwal, Gaurav title: Association of Cardiovascular Disease with Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis date: 2020-04-28 words: 2541 flesch: 39 summary: key: cord-300811-l4y7df2f authors: Aggarwal, Gaurav; Cheruiyot, Isaac; Aggarwal, Saurabh; Wong, Johnny; Lippi, Giuseppe; Lavie, Carl J.; Henry, Brandon M.; Sanchis-Gomar, Fabian title: Association of Cardiovascular Disease with Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis date: 2020-04-28 journal: Curr Probl Cardiol DOI: 10.1016/j.cpcardiol.2020.100617 sha: doc_id: 300811 cord_uid: l4y7df2f Observational studies have reported an association between underlying cardiovascular diseases (CVD) and worse prognosis in COVID-19 patients, but this still remains unclear. We conducted a meta-analysis of recent studies that reported the association of CVD with worse prognosis and increased mortality in COVID-19 patients. keywords: covid-19; cvd; disease; mortality; patients; studies cache: cord-300811-l4y7df2f.txt plain text: cord-300811-l4y7df2f.txt item: #1658 of 2876 id: cord-300866-cso6l6ze author: Bao, Yi title: Clinical Features of COVID-19 in a Young Man with Massive Cerebral Hemorrhage—Case Report date: 2020-05-23 words: 4256 flesch: 46 summary: The treatment of COVID-19 patients with intracerebral hemorrhage suggesting that antiviral treatment was effective. Contact history of the epidemic area and close contact history of COVID-19 confirmed patients were denied. keywords: blood; clinical; cov-2; covid-19; density; hemorrhage; infection; patient; sars; treatment cache: cord-300866-cso6l6ze.txt plain text: cord-300866-cso6l6ze.txt item: #1659 of 2876 id: cord-300963-1n1f8mf2 author: Gajendran, Mahesh title: Inflammatory bowel disease amid the COVID-19 pandemic: impact, management strategies, and lessons learned date: 2020-10-12 words: 6697 flesch: 43 summary: Patients with COVID-19 have lymphopenia, whereas in IBD patients, lymphocyte levels are usually normal or elevated. Hence, there is an ongoing concern over the impact of COVID-19 on IBD patients and their susceptibility to it. keywords: bowel; cells; coronavirus; covid-19; disease; ibd; ibd patients; infection; management; pandemic; patients; risk; rna; sars; study cache: cord-300963-1n1f8mf2.txt plain text: cord-300963-1n1f8mf2.txt item: #1660 of 2876 id: cord-300995-tqz2bkdo author: Tagliaferri, Luca title: Skin cancer triage and management during COVID‐19 pandemic date: 2020-04-25 words: 1413 flesch: 36 summary: We suggest practical recommendations about follow-up and treatment of skin cancer patients during the COVID-19 pandemic. A useful approach, as already suggested by other authors, is to identify the different classes of priorities, both for the patients and for health professionals [5, 6] .Only a few national and international societies have released specific recommendations for skin cancer patients [7] . keywords: cancer; covid-19; patients; risk cache: cord-300995-tqz2bkdo.txt plain text: cord-300995-tqz2bkdo.txt item: #1661 of 2876 id: cord-301011-xbuqd0j5 author: Felten-Barentsz, Karin M title: Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19 date: 2020-06-18 words: 3953 flesch: 32 summary: Therefore, we recommend to not detach the ventilation system for the purpose of respiratory function testing, respiratory muscle training, or breathing exercises. The team may decide that benefits of respiratory muscle training outweigh the safety risks. keywords: covid-19; hospital; mobilization; muscle; patients; recommendations; support; therapists; training cache: cord-301011-xbuqd0j5.txt plain text: cord-301011-xbuqd0j5.txt item: #1662 of 2876 id: cord-301079-n1nytr6k author: Tan, Li title: Air and surface contamination by SARS-CoV-2 virus in a tertiary hospital in Wuhan, China date: 2020-07-27 words: 3558 flesch: 51 summary: Third, the sensitivity and specificity of RT-PCR tests on surface contamination samples might not be same as those from human specimens. Contamination rates was slightly higher near severe/critical patients compared to those near mild patients, although not statistically significant (p <0.05). keywords: air; contamination; patients; samples; sars; surfaces cache: cord-301079-n1nytr6k.txt plain text: cord-301079-n1nytr6k.txt item: #1663 of 2876 id: cord-301087-9vl5pqi7 author: Teh, Benjamin W. title: Risks and burden of viral respiratory tract infections in patients with multiple myeloma in the era of immunomodulatory drugs and bortezomib: experience at an Australian Cancer Hospital date: 2014-12-10 words: 2634 flesch: 37 summary: Whilst the epidemiology, clinical outcomes and risk factors associated with viral RTI (vRTI) are well known in the haematopoietic stem cell transplant (HSCT) setting and supported by appropriate management guidelines, these characteristics have not been reported in myeloma patients managed with novel agents This study highlights the need for awareness of RV infections amongst myeloma patients and that a subgroup at high risk for complications can be identified. keywords: episodes; influenza; myeloma; patients; study; treatment; vrti cache: cord-301087-9vl5pqi7.txt plain text: cord-301087-9vl5pqi7.txt item: #1664 of 2876 id: cord-301146-no9pw4gn author: Lattenist, R. title: COVID-19 in Adult Patients with Hematological Disease: Analysis of Clinical Characteristics and Outcomes date: 2020-07-07 words: 868 flesch: 45 summary: Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China COVID-19 in persons with haematological cancers Survival study of hospitalised patients with concurrent COVID-19 and haematological malignancies Case fatality rate of cancer patients with COVID-19 in a New York hospital system Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study Acknowledgements All authors contributed to the management of patients. However, data on patients with COVID-19 and an underlying hematological disease as well as on specific risks factors in this particularly immunocompromised population are scarce [2] [3] [4] [5] . keywords: covid-19; patients; study cache: cord-301146-no9pw4gn.txt plain text: cord-301146-no9pw4gn.txt item: #1665 of 2876 id: cord-301148-duttw9xn author: Golestanieraghi, Majid title: Early application of prone position for management of Covid-19 patients date: 2020-05-26 words: 203 flesch: 39 summary: We had 10 cases of COVID-19 patients with hypoxemia (PaO 2 /FiO 2 <150) which were awake and non-agitated. As Clinical features of patients infected with 2019 novel coronavirus in Wuhan Novel Wuhan (2019-nCoV) coronavirus Effect of the prone position on patients with hydrostatic pulmonary edema compared with patients with acute respiratory distress syndrome and pulmonary fibrosis Body positioning may affect lung recruitability in COVID-19-related ARDS keywords: patients cache: cord-301148-duttw9xn.txt plain text: cord-301148-duttw9xn.txt item: #1666 of 2876 id: cord-301281-yur5hs2h author: Zelek, Wioleta M. title: Complement Inhibition with the C5 Blocker LFG316 in Severe COVID-19 date: 2020-11-01 words: 1682 flesch: 34 summary: COVID-19 does not lead to a typical acute respiratory distress syndrome Efficacy of prone position in acute respiratory distress syndrome patients: a pathophysiology-based review Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome Respiratory pathophysiology of mechanically ventilated patients with COVID-19: a cohort study Electrical impedance tomography for positive end-expiratory pressure titration in COVID-19-related acute respiratory distress syndrome Respiratory mechanics of COVID-19-versus non-COVID-19-associated acute respiratory distress syndrome Recruitability and effect of PEEP in SARS-Cov-2-associated acute respiratory distress syndrome Lung recruitability in COVID-19-associated acute respiratory distress syndrome: a single-center observational study Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Temporal changes of CT findings in 90 patients with COVID-19 pneumonia: a longitudinal study Complement, a target for therapy in inflammatory and degenerative diseases Targeting complement pathways in polytrauma-and sepsis-induced multiple-organ dysfunction Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases Explore COVID-19 IPH group; Explore COVID-19 Marseille Immunopole group. Notably, Edwards and colleagues (2) developed a clinical screening tool to identify OSA patients with low ArTH Resp based on three predictive variables obtained from standard overnight sleep studies (i.e., polysomnograms [PSGs]): 1) nadir oxygen saturation keywords: blockade; complement; covid-19; patients cache: cord-301281-yur5hs2h.txt plain text: cord-301281-yur5hs2h.txt item: #1667 of 2876 id: cord-301340-lhh04pum author: Jamieson, Frances B. title: Human Torovirus: A New Nosocomial Gastrointestinal Pathogen date: 1998-11-17 words: 3411 flesch: 35 summary: We used McNemar's x 2 test to compare concordance of matched pairs of gastroenteritis patients and asymptomatic controls described in study 1. Particles resembling toroviruses have been reported in stools of gastroenteritis patients, although in some cases they were designated coronavirus-like particles [15, [31] keywords: diarrhea; gastroenteritis; patients; specimens; stool; study; torovirus cache: cord-301340-lhh04pum.txt plain text: cord-301340-lhh04pum.txt item: #1668 of 2876 id: cord-301342-ikvpkhfp author: Xue, Katherine S title: Parallel evolution of influenza across multiple spatiotemporal scales date: 2017-06-27 words: 6118 flesch: 40 summary: A virus Clinical outcomes associated with respiratory virus detection before allogeneic hematopoietic stem cell transplant Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses Deep sequencing reveals potential antigenic variants at low frequencies in Influenza A Virus-Infected humans Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution Unifying the epidemiological and evolutionary dynamics of pathogens An equivalence principle for the incorporation of favorable mutations in asexual populations Human immunodeficiency virus type 1 env evolves toward ancestral states upon transmission to a new host Intrahost evolutionary dynamics of canine influenza virus in naive and partially immune dogs Universal primer set for the full-length amplification of all influenza A viruses Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae Substitutions near the receptor binding site determine Major antigenic change during influenza virus evolution Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations Fast gapped-read alignment with bowtie 2 HIV evolutionary dynamics within and among hosts HIV evolution: ctl escape mutation and reversion after transmission Immune history shapes specificity of pandemic H1N1 influenza antibody responses Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season A predictive fitness model for influenza Predicting evolution Cutadapt removes adapter sequences from high-throughput sequencing reads Measurements of Intrahost viral diversity are extremely sensitive to systematic errors in variant calling Antigenic drift of influenza A (H3N2) virus in a persistently infected immunocompromised host is similar to that occurring in the community The natural history of influenza infection in the severely immunocompromised vs nonimmunocompromised hosts Intra-and interhost evolutionary dynamics of equine influenza virus Genetic draft, selective interference, and population genetics of rapid adaptation Predicting evolution from the shape of genealogical trees Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy Quantifying influenza virus diversity and transmission in humans Evolutionary analysis of the dynamics of viral infectious disease The genomic and epidemiological dynamics of human influenza A virus Emerging oseltamivir resistance in seasonal and pandemic influenza A/ H1N1 EMBOSS: the european molecular Biology Open Software Suite Antigenic and genetic variation in influenza A (H1N1) virus isolates recovered from a persistently infected immunodeficient child Intrahost dynamics of antiviral resistance in influenza A virus reflect complex patterns of segment linkage, reassortment, and natural selection Deep sequencing of Influenza A virus from a human challenge study reveals a selective bottleneck and only limited Intrahost Genetic diversification RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies Clonal interference in the evolution of influenza Influenza A virus transmission bottlenecks are defined by infection route and recipient host The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor Refinement of the influenza virus hemagglutinin by simulated annealing GGTREE: an R package forvisualization and annotation of phylogenetic trees with theircovariates and otherassociated data Population genomics of intrapatient HIV-1 evolution We thank Choli Lee and Seungsoo Kim for assistance with sequencing; Darneshia Smith for sample management; Louise Kimball and Alpana Waghmare for interpretation of patient clinical data; and Seungsoo Kim, Alexander Greninger, and Trevor Bedford for comments and discussion about the manuscript. The selective pressures at these various scales reflect complex molecular, immunological, and epidemiological constraints (Grenfell et al., 2004; Pybus and Rambaut, 2009; Luksza and Lässig, 2014; Neher et al., 2016) , which have formed the basis of recent efforts to forecast influenza evolution (Luksza and Lässig, 2014; Neher et al., 2016 , Neher et al., 2014 Lässig et al., 2017) . keywords: et al; evolution; figure; host; influenza; mutations; patients; samples; sites cache: cord-301342-ikvpkhfp.txt plain text: cord-301342-ikvpkhfp.txt item: #1669 of 2876 id: cord-301391-5dvf1mi0 author: Islam, Md. Milon title: Breathing Aid Devices to Support Novel Coronavirus (COVID-19)Infected Patients date: 2020-08-19 words: 4402 flesch: 51 summary: We described the most recent developed breathing aid devices such as oxygen therapy devices, ventilator, and CPAP throughout the review. Oxygen therapy devices [30, 31] are an appropriate solution for the COVID-19 patients, generally available in hospitals as well as ambulance. keywords: air; breathing; cost; covid-19; cpap; devices; oxygen; patients; support; therapy; ventilator cache: cord-301391-5dvf1mi0.txt plain text: cord-301391-5dvf1mi0.txt item: #1670 of 2876 id: cord-301402-andxwyi3 author: Ding, Benjamin Tze Keong title: Operating in a Pandemic: Lessons and Strategies from an Orthopaedic Unit at the Epicenter of COVID-19 in Singapore date: 2020-05-06 words: 3905 flesch: 34 summary: When managing patients with COVID-19, double gloves are utilized to preserve PPE, and not to reduce the risk of viral transmission, such that only the outer gloves need to be changed when soiled or when managing multiple patients 19 . At an organizational level, there were dedicated isolation wards and triage areas, training and monitoring of hospital staff in infection-control procedures, strict enforcement of droplet precautions for COVID-19 patients, and minimization of staff exposure to high-risk aerosol-generating procedures. keywords: care; covid-19; health; infection; n95; pandemic; patients; ppe; surgery; transmission; use; workers cache: cord-301402-andxwyi3.txt plain text: cord-301402-andxwyi3.txt item: #1671 of 2876 id: cord-301521-mpm43aga author: Teixeira, Andre Luiz Schuh title: La urgencia de implementar y ampliar la telepsiquiatría durante la crisis de COVID-19: perspectiva de los psiquiatras que inician su carrera date: 2020-06-12 words: 940 flesch: 38 summary: key: cord-301521-mpm43aga authors: Teixeira, Andre Luiz Schuh; Spadini, Alex Vicente; Pereira-Sanchez, Victor; Ojeahere, Margaret Isioma; Morimoto, Kana; Chang, Alice; de Filippis, Renato; Soler-Vidal, Joan title: La urgencia de implementar y ampliar la telepsiquiatría durante la crisis de COVID-19: perspectiva de los psiquiatras que inician su carrera date: 2020-06-12 journal: Rev Psiquiatr Salud Ment DOI: 10.1016/j.rpsm.2020.06.001 sha: doc_id: 301521 cord_uid: mpm43aga nan If few months ago, psychiatrists were told that their practice would be transformed and mental health care would be compelled to reinvent due to a respiratory syndrome, few would have believed it. The current one has the potential to show that technology can facilitate access to mental health care. keywords: care; health; patients; telepsychiatry cache: cord-301521-mpm43aga.txt plain text: cord-301521-mpm43aga.txt item: #1672 of 2876 id: cord-301579-q23nhmgs author: Tabaza, Luai title: Robotic‐assisted percutaneous coronary intervention in a COVID‐19 patient date: 2020-05-20 words: 1112 flesch: 28 summary: R-PCI has been approved for coronary interventions and has had increasing adoption in elective and complex procedures globally. key: cord-301579-q23nhmgs authors: Tabaza, Luai; Virk, Hafeez ul Hassan; Janzer, Sean; George, Jon C. title: Robotic‐assisted percutaneous coronary intervention in a COVID‐19 patient date: 2020-05-20 journal: Catheter Cardiovasc Interv DOI: 10.1002/ccd.28982 sha: doc_id: 301579 cord_uid: q23nhmgs Coronavirus disease‐2019 (COVID‐19) pandemic is the biggest global health threat in the 21st century. keywords: covid-19; intervention; patient; pci cache: cord-301579-q23nhmgs.txt plain text: cord-301579-q23nhmgs.txt item: #1673 of 2876 id: cord-301590-70qmpccs author: Campos, António title: The Paradigm Shift of Ophthalmology in the COVID-19 Era date: 2020-09-14 words: 3014 flesch: 44 summary: The manuscript management system is completely online and includes a very quick and fair peer-review system JM and HA volunteered to assist COVID-19 patients at the emergency dedicated tent and ward in the months of March, April and May 2020.We thank Anália Carmo, MD, MSc, PhD, http://orcid.org/ 0000-0002-7704-4736, from the Laboratory of Molecular Biology/Virology, Clinical Pathology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, All authors made a significant contribution to the work reported, being involved in the conception, study design, execution, acquisition of data, analysis and interpretation. We are facing a different sort of challenge now: how to accommodate the usual huge number of patients previous to the COVID-19 outbreak in the waiting rooms, while respecting the new demands from the healthcare authorities to reduce the number of waiting patients to a half or one-third. keywords: cov-2; covid-19; injections; number; patients; rooms; sars; visits cache: cord-301590-70qmpccs.txt plain text: cord-301590-70qmpccs.txt item: #1674 of 2876 id: cord-301592-n5ns3m34 author: Ivaska, Lauri title: Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection date: 2017-01-07 words: 4145 flesch: 42 summary: Blood MxA levels were lower in virus positive patients at the follow-up visit (110 [70e218] mg/L; median [IQR]) than they were during the febrile pharyngitis episode (780 [180e1190] mg/L). Furthermore, an elevated blood MxA level, as a marker of type I or type III interferon production, demonstrated an active innate immune response against acute virus infection in the majority of patients with a detected virus. keywords: blood; children; gas; group; mxa; patients; pharyngitis; study; virus; viruses cache: cord-301592-n5ns3m34.txt plain text: cord-301592-n5ns3m34.txt item: #1675 of 2876 id: cord-301779-y07xjnpe author: Fox, Sharon E title: Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans date: 2020-05-27 words: 3289 flesch: 39 summary: Autopsy can considerably contribute to our understanding of many disease processes and could provide crucial information to guide management of patients with coronavirus disease 2019 (COVID-19). Features of diffuse alveolar damage, including hyaline membranes, were present, even in patients who had not been ventilated. keywords: appendix; covid-19; figure; findings; infection; lungs; patients; sars cache: cord-301779-y07xjnpe.txt plain text: cord-301779-y07xjnpe.txt item: #1676 of 2876 id: cord-301800-ssdzd43t author: Atal, Shubham title: Approval of Itolizumab for COVID-19: A Premature Decision or Need of The Hour? date: 2020-10-13 words: 4516 flesch: 40 summary: DCGI gives Nod for Restricted Emergency Use to Itolizumab for moderate to severe COVID-19 patients ?o=rn&id=58171 &SEO=cuba-autho rizes -the-use-of-itoli zumab -in-cases -of-covid -19 Emergency use authorization Itolizumab-a humanized anti-CD6 monoclonal antibody with a better side effects profile for the treatment of psoriasis Itolizumab provides sustained remission in plaque psoriasis: a 5-year follow-up experience An anti-CD6 monoclonal antibody (Itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients A multi-centre, open label, two arm randomized, pivotal phase 2 trial to study the efficacy and safety of itolizumab in COVID-19 complications Biocon to give more data on itolizumab after use in covid-19 treatment rejected Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab A clinical exploratory study with itolizumab, an anti-CD6 monoclonal antibody, in patients with rheumatoid arthritis Alzumab (Itolizumab) solution for iv infusion Rationale for targeting CD6 as a treatment for autoimmune diseases Safety, efficacy and pharmacokinetics of T1h, a humanized anti-CD6 monoclonal antibody, in moderate to severe chronic plaque psoriasis-results from a randomized phase II trial Efficacy and safety of itolizumab, a novel anti-CD6 monoclonal antibody, in patients with moderate to severe chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, phase-III study Itolizumab, an anti-CD6 monoclonal antibody, as a potential treatment for COVID-19 complications IL-6 inhibitors in the treatment of serious COVID-19: a promising therapy? On the basis of the results of this phase II trial, itolizumab was granted approval for 'restricted emergency use' for this indication in COVID-19 patients in July 2020 keywords: approval; covid-19; drug; itolizumab; patients; phase; study; treatment; trial; use cache: cord-301800-ssdzd43t.txt plain text: cord-301800-ssdzd43t.txt item: #1677 of 2876 id: cord-301805-sb0ij8k7 author: Fuentes, Blanca title: Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study date: 2020-11-04 words: 3839 flesch: 37 summary: Intervention After the participants sign the informed consent form, they will be implanted a CGM subcutaneously to monitor glucose levels for 96 h. These devices are of common use in the management of type 1 diabetes and they have been proven to be safe in stroke patients when used in research studies. Recruitment started on Glycemic variability: a strong independent predictor of mortality in critically ill patients Glucose variability is associated with intensive care unit mortality* Glycemic variability and acute ischemic stroke: the missing link? Effects of glycemic variability and hyperglycemia in acute ischemic stroke on post-stroke cognitive impairments Range of glucose as a glycemic variability and 3-month outcome in diabetic patients with acute ischemic stroke Management of hyperglycemia in patients with acute ischemic stroke: comparison of two strategies Outcome prediction in acute stroke patients by continuous glucose monitoring Post stroke dysglycemia and acute infarct volume growth: a study using continuous glucose monitoring Variability of blood glucose concentration and short-term mortality in critically ill patients Increased glycemic variability is independently associated with length of stay andmortality in noncritically ill hospitalized patients Glycemia in Acute Stroke II study: a call to improve post-stroke hyperglycemia management in clinical practice Sliding scale insulin-time to stop sliding Various blood glucose parameters that indicate hyperglycemia after intravenous thrombolysis in acute ischemic stroke could predict worse outcome Glucose and stroke: What about glycemic variability? Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults Continuous glucose monitoring in insulintreated patients in non-ICU settings Glucose variability; does it matter? keywords: acute; content; follow; glucose; hyperglycemia; manuscript; patients; revision; stroke; study cache: cord-301805-sb0ij8k7.txt plain text: cord-301805-sb0ij8k7.txt item: #1678 of 2876 id: cord-301811-ykpiorgo author: Tanaka, Takuma title: Estimation of the percentages of undiagnosed patients of the novel coronavirus (SARS-CoV-2) infection in Hokkaido, Japan by using birth-death process with recursive full tracing date: 2020-10-28 words: 5533 flesch: 53 summary: If the individuals who came into contact with diagnosed patients had been so intensively tested that a much larger number of asymptomatic patients had been diagnosed, the analysis would have needed an extended model including asymptomatic diagnosed patients. Moreover, our model cannot utilize information on asymptomatic diagnosed patients. keywords: asymptomatic; contact; individuals; model; number; patients; tracing cache: cord-301811-ykpiorgo.txt plain text: cord-301811-ykpiorgo.txt item: #1679 of 2876 id: cord-301832-6czrdmzb author: Leber, Danielle title: PC-FACS September 1, 2020 date: 2020-09-06 words: 2363 flesch: 45 summary: Fourth, when patients who use ventilators in their daily lives (eg, home ventilation) present to acute care, their ventilators should not be reallocated to other patients. This article provides some insights that can help palliative care practitioners give more accurate prognostic information to older patients with onset of disability and their families. keywords: adrd; care; disability; palliative; patients; recovery; spd cache: cord-301832-6czrdmzb.txt plain text: cord-301832-6czrdmzb.txt item: #1680 of 2876 id: cord-301947-b6nwaost author: Millán-Oñate, José title: Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin date: 2020-04-24 words: 3712 flesch: 45 summary: Even, there is a lack of case reports of COVID-19 patients recovering from SARS-CoV-2 infection [21, 22] . In Colombia, the Ministry of Health and the Colombian Association of Infectious Diseases [38] , have considered the possible use of chloroquine for COVID-19 patients, in those hospitalized under close medical observation, as was our case. keywords: case; chloroquine; clinical; coronavirus; cov-2; covid-19; day; patient; sars; treatment cache: cord-301947-b6nwaost.txt plain text: cord-301947-b6nwaost.txt item: #1681 of 2876 id: cord-301992-oin1m0uq author: Ferreira, Cristine Homsi Jorge title: A guide to physiotherapy in urogynecology for patient care during the COVID-19 pandemic date: 2020-09-28 words: 4350 flesch: 32 summary: Telephysiotherapy is an option for continuity of care during the pandemic, especially considering that education is a large component in physiotherapy, opening new perspectives for the development of practice and research in urogynecology and pelvic health. Physiotherapy is a profession that focuses on human movement and functionality [5] , basing its interventions on thorough evaluation of general aspects regarding symptoms and specific aspects related to pelvic floor muscle (PFM) function and dysfunctions in the field of women's health. keywords: care; floor; health; pandemic; patients; pelvic; physiotherapy; treatment; use; women cache: cord-301992-oin1m0uq.txt plain text: cord-301992-oin1m0uq.txt item: #1682 of 2876 id: cord-302062-wqmynngg author: Sierra-Hidalgo, Fernando title: Large artery ischemic stroke in severe COVID-19 date: 2020-06-27 words: 1147 flesch: 41 summary: key: cord-302062-wqmynngg authors: Sierra-Hidalgo, Fernando; Muñoz-Rivas, Nuria; Torres Rubio, Pedro; Chao, Kateri; Villanova Martínez, Mercedes; Arranz García, Paz; Martínez-Acebes, Eva title: Large artery ischemic stroke in severe COVID-19 date: 2020-06-27 journal: J Neurol DOI: 10.1007/s00415-020-09967-1 sha: doc_id: 302062 cord_uid: wqmynngg nan The coronavirus disease 2019 (COVID-19) pandemic has spread rapidly all around the world. Ischemic stroke occurred a median of 11.5 days after the onset of COVID-19 symptoms (interquartile range, IQR 2.8-16.3). keywords: covid-19; ischemic; patients; stroke cache: cord-302062-wqmynngg.txt plain text: cord-302062-wqmynngg.txt item: #1683 of 2876 id: cord-302115-r39ser2c author: Matricardi, Paolo Maria title: The first, holistic immunological model of COVID‐19: implications for prevention, diagnosis, and public health measures date: 2020-05-02 words: 3743 flesch: 37 summary: medRxiv preprint 2020 Minimum infective dose of the major human respiratory and enteric viruses transmitted through food and the environment SARS-CoV-2 viral load and the severity of COVID-19 Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case Data SARS-CoV-2 viral load in upper respiratory specimens of infected patients Chest CT Findings in Cases from the Cruise Ship Diamond Princess Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for Accepted Article Among them, hospital doctors frequently exposed to COVID-19 patients are, unfortunately, highly represented. keywords: article; copyright; coronavirus; cov-2; covid-19; patients; pneumonia; respiratory; rights; sars cache: cord-302115-r39ser2c.txt plain text: cord-302115-r39ser2c.txt item: #1684 of 2876 id: cord-302177-8w3ojgd4 author: Cavayas, Yiorgos Alexandros title: Early experience with critically ill patients with COVID-19 in Montreal date: 2020-09-15 words: 4084 flesch: 53 summary: A significant proportion of ICU patients likely acquired the virus in healthcare facilities, highlighting the importance of appropriate infection control policies. 11, 12 Intensive care unit admission criteria for COVID-19 patients included an oxygen requirement of [ 5 LÁmin -1 accompanied with signs of respiratory distress. keywords: care; cases; covid-19; hospital; icu; imv; mortality; outcomes; patients; ventilation cache: cord-302177-8w3ojgd4.txt plain text: cord-302177-8w3ojgd4.txt item: #1685 of 2876 id: cord-302215-sqrbj5r4 author: Vanden Eynde, Jean Jacques title: COVID-19: An Update about the Discovery Clinical Trial date: 2020-05-14 words: 3343 flesch: 44 summary: [2] , for a potential treatment, we analyzed the evolution of the number of clinical trials on April 8, April 28, and May 4. Comparison with clinical trials reported in the Chinese Clinical Trial Registry keywords: combination; covid-19; hydroxychloroquine; patients; remdesivir; treatment; trial cache: cord-302215-sqrbj5r4.txt plain text: cord-302215-sqrbj5r4.txt item: #1686 of 2876 id: cord-302226-0rhgmtbo author: Bajpai, Vijeta title: Spectrum of respiratory viral infections in liver disease patients with cirrhosis admitted in critical care unit date: 2019 words: 2255 flesch: 40 summary: Pneumonia in patients with cirrhosis: Risk factors associated with mortality and predictive value of prognostic models Community-acquired pneumonia in patients with liver cirrhosis: Clinical features, outcomes, and usefulness of severity scores High mortality of pneumonia in cirrhotic patients with ascites Bacterial infections in cirrhosis: A position statement based on the EASL special conference Bacterial infections in end-stage liver disease: Current challenges and future directions Bacterial infections in patients with liver cirrhosis Influenza A/ H1N1pdm 09 infection in liver disease patients requiring ICU care A/H1N1/09 influenza is associated with high mortality in liver cirrhosis Clinical impact of A/H1/N1/09 influenza in patients with cirrhosis: Experience from a nosocomial cluster of infection Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the infectious diseases society of America and the American thoracic society Predictive value of testing nasopharyngeal samples for respiratory viruses in the setting of lower respiratory tract disease Comparison of viral infection in healthcare-associated pneumonia (HCAP) and community-acquired pneumonia (CAP) Incidence of respiratory viruses in patients with community-acquired pneumonia admitted to the intensive care unit: Results from the severe influenza pneumonia surveillance (SIPS) project Influenza A/H1/N1/09 infection in patients with cirrhosis has a poor outcome: A case series Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang Viral and bacterial co-infection in severe pneumonia triggers innate immune responses and specifically enhances IP-10: A translational study Viral-bacterial interactions in the respiratory tract Secondary bacterial infections associated with influenza pandemics We would like to thank all the innocent patients for agreeing in the study and for donating their clinical samples. Specimens obtained from the upper airway as TS/NS are often used for RV testing in pneumonia patients due to ease of specimen collection in comparison to bronchoscopy collected BAL sample. keywords: ccus; cirrhosis; patients; pneumonia; rvs; study cache: cord-302226-0rhgmtbo.txt plain text: cord-302226-0rhgmtbo.txt item: #1687 of 2876 id: cord-302244-uwicyuhk author: Hoilat, Gilles J title: Percutaneous Mechanical Pulmonary Thrombectomy in a Patient With Pulmonary Embolism as a First Presentation of COVID-19 date: 2020-08-01 words: 1198 flesch: 45 summary: One retrospective study performed by Bompard et al. reported that out of 137 patients who underwent CT pulmonary angiography, 50% of them were found to have acute pulmonary embolism COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure Coagulation and sepsis Clinical characteristics of coronavirus disease 2019 in China Pulmonary embolism in patients with Covid-19 pneumonia Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Pulmonary embolism in patients with COVID-19: time to change the paradigm of computed tomography The incidence of acute pulmonary embolism in a patient with COVID-19 remains unknown [6] . keywords: covid-19; embolism; patients; pulmonary cache: cord-302244-uwicyuhk.txt plain text: cord-302244-uwicyuhk.txt item: #1688 of 2876 id: cord-302316-raf5rlkq author: Brüssow, Harald title: COVID‐19: From pathogenesis models to the first drug trials date: 2020-06-23 words: 6948 flesch: 40 summary: A Chinese study used anakinra in severe COVID-19 patients who could not receive intensive care due to overwhelming patient numbers. The Authors Isolation of SARS-CoV-2-related coronavirus from malayan pangolins Pathological findings of COVID-19 associated with acute respiratory distress syndrome Effective treatment of severe COVID-19 patients with tocilizumab Effect of convalescent plasma therapy on viral shedding and survival in COVID-19 patients SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues I thank Jacqueline Steinhauser, and Kenneth Timmis and Lutz Br€ ussow for critical reading of the manuscript. keywords: cell; cov-2; covid-19; disease; group; infection; interferon; lung; patients; sars; study; treatment; trial; virus cache: cord-302316-raf5rlkq.txt plain text: cord-302316-raf5rlkq.txt item: #1689 of 2876 id: cord-302382-eifh95zm author: Owji, Hajar title: Immunotherapeutic approaches to curtail COVID-19 date: 2020-08-21 words: 11329 flesch: 34 summary: Immunology The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells TNF-[alpha] inhibition for potential therapeutic modulation of SARS coronavirus infection Anti-inflammatory effect of thalidomide on H1N1 influenza virus-induced pulmonary injury in mice CD24 and Siglec-10 selectively repress tissue damage-induced immune responses CD24 and By contrast, a retrospective analysis of 401 patients with severe SARS revealed that corticosteroids led to reduced mortality rate and shortened hospital stay [163] . keywords: antibodies; antibody; cells; convalescent; coronavirus; cov-2; covid-19; cytokine; disease; human; immune; infection; inhibitors; monoclonal; patients; plasma; protein; responses; sars; syndrome; system; treatment cache: cord-302382-eifh95zm.txt plain text: cord-302382-eifh95zm.txt item: #1690 of 2876 id: cord-302389-h7jm1etb author: Moazenzadeh, Mansoor title: First reported case of unrepaired tetralogy of Fallot complicated with coronavirus disease-19 (COVID-19) date: 2020-06-11 words: 1662 flesch: 42 summary: Regarding the different physiology and anatomy of adult patients with CHDs, efforts are necessary to be made by related national and international societies of adult CHDs to collect data from a number of assumed and established cases to better recognise the prognosis of this special group and to develop specific protocols for treating adult CHDs patients who are infected by COVID-19. Although the prevalence of the disease has not yet been fully established and numerous articles have been reported in recent weeks about the disease, there is still little evidence of the course of the disease among adult patients with CHD. keywords: adult; covid-19; disease; patients; right cache: cord-302389-h7jm1etb.txt plain text: cord-302389-h7jm1etb.txt item: #1691 of 2876 id: cord-302403-kahi8cbc author: Miller, Robert F. title: Pulmonary Infections date: 2009-05-15 words: 18178 flesch: 41 summary: The course of HIV infection can be divided clinically into several distinct periods: Acquisition of the virus Seroconversion, with or without a clinical illness (primary HIV infection) Tuberculosis HIV infection is associated with at least a 40-fold increased risk of an individual having active tuberculosis develop compared with noninfected subjects. keywords: bacterial; bal; blood; cd4; cells; counts; diagnosis; disease; drug; haart; hiv; hiv infection; individuals; infection; patients; pcp; pneumonia; prophylaxis; pulmonary; risk; therapy; treatment; tuberculosis cache: cord-302403-kahi8cbc.txt plain text: cord-302403-kahi8cbc.txt item: #1692 of 2876 id: cord-302413-7a80jff2 author: Brown, Timothy S. title: The Effect of The COVID-19 Pandemic On Electively Scheduled HIP and KNEE Arthroplasty Patients in THE United States date: 2020-04-22 words: 1851 flesch: 51 summary: 47 48 We administered a novel questionnaire to our elective hip and knee patients affected by 50 the COVID-19 pandemic. We aimed to assess the effect this had on our elective primary arthroplasty patients by distributing a specifically designed survey to patients across six institutions identified through the AAHKS Research Committee. keywords: anxiety; covid-19; hip; pandemic; patients cache: cord-302413-7a80jff2.txt plain text: cord-302413-7a80jff2.txt item: #1693 of 2876 id: cord-302448-2r4rtixg author: Kharma, Nadir title: Anticoagulation in critically ill patients on mechanical ventilation suffering from COVID-19 disease, The ANTI-CO trial: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-07 words: 1837 flesch: 47 summary: key: cord-302448-2r4rtixg authors: Kharma, Nadir; Roehrig, Stefan; Shible, Ahmed Atef; Elshafei, Moustafa Sayed; Osman, Dema; Elsaid, Ingi Mohamed; Mustafa, Salma Faisal; Aldabi, Asjad; Smain, Osamah A.M.; Lance, Marcus D. title: Anticoagulation in critically ill patients on mechanical ventilation suffering from COVID-19 disease, The ANTI-CO trial: A structured summary of a study protocol for a randomised controlled trial date: 2020-09-07 journal: Trials DOI: 10.1186/s13063-020-04689-1 sha: doc_id: 302448 cord_uid: 2r4rtixg OBJECTIVES: To assess the effect of anticoagulation with bivalirudin administered intravenously on gas-exchange in patients with COVID-19 and respiratory failure using invasive mechanical ventilation. The protocol is registered before starting subject recruitment under the title: “Anticoagulation in patients suffering from COVID-19 disease. keywords: bivalirudin; data; group; patients; protocol; treatment cache: cord-302448-2r4rtixg.txt plain text: cord-302448-2r4rtixg.txt item: #1694 of 2876 id: cord-302459-grs2x26l author: Matin, Farhana title: A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer date: 2018-04-27 words: 8323 flesch: 39 summary: The translational potential of microRNAs as biofluid markers of urological tumours Phase 2 study of circulating microRNA biomarkers in castration-resistant prostate cancer Human seminal fluid as a source of prostate cancer-specific microRNA biomarkers Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease Circulating microRNAs predict biochemical recurrence in prostate cancer patients MicroRNA Theranostics in Prostate Cancer Precision Medicine miRNet -dissecting miRNA-target interactions and functional associations through network-based visual analysis Circulating microRNA profiling identifies a subset of metastatic prostate cancer patients with evidence of cancerassociated hypoxia Plasma miRNAs as biomarkers to identify patients with castration-resistant metastatic prostate cancer Effects of pooling samples on the performance of classification algorithms: a comparative study Next Generation Sequencing of Pooled Samples: Guideline for Variants' Filtering Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lower Prostate-specific antigen and prostate cancer: prediction, detection and monitoring Diagnostic, prognostic and predictive value of cell-free miRNAs in prostate cancer: a systematic review A circulating miRNA assay as a first-line test for prostate cancer screening PSA testing for men at average risk of prostate cancer Prostate-Specific Antigen (PSA)-Based Population Screening for Prostate Cancer: An Evidence-Based Analysis Phase of care prevalence for prostate cancer in New South Wales, Australia: A population-based modelling study Prostate cancer screening in Australia: Position statement Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement The relationship between amniotic fluid miRNAs and congenital obstructive nephropathy A Computational Approach for Predicting Role of Human MicroRNAs in MERS-CoV Genome Novel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profiling A novel microRNAs expression signature for hepatocellular carcinoma diagnosis and prognosis MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells miR-98 inhibits expression of TWIST to prevent progression of non-small cell lung cancers MicroRNA-98-5p inhibits cell proliferation and induces cell apoptosis in hepatocellular carcinoma via targeting IGF2BP1 Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy miR-152 controls migration and invasive potential by targeting TGFalpha in prostate cancer cell lines MicroRNA profiling of novel African American and Caucasian Prostate Cancer cell lines reveals a reciprocal regulatory relationship of miR-152 and DNA methyltranferase 1 Clinical significance of miRNA host gene promoter methylation in prostate cancer Evaluation of Plasma miR-21 and miR-152 as Diagnostic Biomarkers for Common Types of Human Cancers Extracellular vesicle transfer of cancer pathogenic components Exosomal tumor microRNA modulates premetastatic organ cells MicroRNAs and metastasis: small RNAs play big roles Exosomes in diagnosis and therapy of prostate cancer Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: key: cord-302459-grs2x26l authors: Matin, Farhana; Jeet, Varinder; Moya, Leire; Selth, Luke A.; Chambers, Suzanne; Clements, Judith A.; Batra, Jyotsna title: A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer date: 2018-04-27 journal: Sci Rep DOI: 10.1038/s41598-018-24424-w sha: doc_id: 302459 cord_uid: grs2x26l Prostate cancer is diagnosed in over 1 million men every year globally, yet current diagnostic modalities are inadequate for identification of significant cancer and more reliable early diagnostic biomarkers are necessary for improved clinical management of prostate cancer patients. keywords: analysis; cancer; cell; cohort; data; discovery; expression; mir-152; mirna; patients; plasma; prostate; prostate cancer; samples; study; validation cache: cord-302459-grs2x26l.txt plain text: cord-302459-grs2x26l.txt item: #1695 of 2876 id: cord-302576-fv2ib5vc author: Barisione, Emanuela title: Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems date: 2020-09-28 words: 5460 flesch: 32 summary: This study uses an innovative cryobiopsy approach for the post-mortem sampling of lung tissues from COVID-19 patients demonstrating the progression of fibrosis in time and correlation with computed tomography features. Following the report of endotheliitis present in COVID-19 patients [27, 28] , this feature was also actively looked for but to no avail. keywords: covid-19; days; disease; findings; histologic; lesions; lung; patients; patterns; phase; sars; study cache: cord-302576-fv2ib5vc.txt plain text: cord-302576-fv2ib5vc.txt item: #1696 of 2876 id: cord-302667-ei151qpd author: Sekar, Raghul title: Challenges Faced by an Otolaryngology Resident During Covid-19 Pandemic: An Indian Perspective date: 2020-09-01 words: 1567 flesch: 47 summary: They shuffle between working with COVID positive patients and returning to treat non-COVID patients in their respective department following a period of quarantine. COVID-19 being primarily a respiratory disease, has tremendous implications in otolaryngology training and patient care. keywords: care; covid; pandemic; patients; residents cache: cord-302667-ei151qpd.txt plain text: cord-302667-ei151qpd.txt item: #1697 of 2876 id: cord-302684-r4ger87o author: Whisenant, Jennifer G. title: TERAVOLT: Thoracic Cancers International COVID-19 Collaboration date: 2020-05-16 words: 2010 flesch: 28 summary: One publication noted that the use of corticosteroids, which are frequently administered to thoracic cancer patients during treatment and for symptom management, may worsen the sequelae of acute respiratory distress syndrome (ARDS) in patients with COVID-19 (Russell et al., 2020) . Many societies have provided treatment recommendations for patients with malignancies during this pandemic, thereby revisiting our standards of care for cancer patients and allowing for a better risk/benefit ratio. keywords: cancer; covid-19; malignancies; patients; risk; thoracic cache: cord-302684-r4ger87o.txt plain text: cord-302684-r4ger87o.txt item: #1698 of 2876 id: cord-302695-vyo3w2a4 author: Albertini, Laetitia title: Observational study on off-label use of tocilizumab in patients with severe COVID-19 date: 2020-09-10 words: 5029 flesch: 58 summary: ► Fifteen percent of COVID-19 patients who suddenly deteriorate 7 or 8 days after the appearance of the symptoms develop acute respiratory distress syndrome. Treated patients tended to be intubated less during the course of the disease (2/22 vs 6/22, 95% CI −0.4 to 0.1; p=0.12). keywords: control; control group; covid-19; days; group; oxygen; patients; tcz; tcz group cache: cord-302695-vyo3w2a4.txt plain text: cord-302695-vyo3w2a4.txt item: #1699 of 2876 id: cord-302756-343y63e5 author: Thachil, J title: Understanding the COVID‐19 coagulopathy spectrum date: 2020-05-21 words: 2230 flesch: 37 summary: Overt bleeding is rare in COVID-19 patients although there are patients who develop disseminated intravascular coagulation (DIC) in common with many patients who are critically unwell. All rights reserved COVID-19 COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country Targeting complement pathways in polytrauma-and sepsis-induced multiple-organ dysfunction Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): a case series Hypercoaguability of COVID-19 patients in Intensive Care Unit. keywords: article; coagulation; copyright; covid-19; patients; system cache: cord-302756-343y63e5.txt plain text: cord-302756-343y63e5.txt item: #1700 of 2876 id: cord-302788-kg8zwysg author: Conrad, Rachel C. title: Duties toward Patients with Psychiatric Illness date: 2020-06-29 words: 1923 flesch: 32 summary: Psychiatric patients have significantly increased risks of suicide, sudden cardiac death, all-cause mortality, and being victims of violence. The therapeutic potential for telehealth services for mental health care may create new outpatient treatment options for some populations. keywords: care; health; illness; patients; psychiatric cache: cord-302788-kg8zwysg.txt plain text: cord-302788-kg8zwysg.txt item: #1701 of 2876 id: cord-302800-852w35od author: Liu, Xuebing title: Clinical characteristics of hospitalised patients with schizophrenia who were suspected to have coronavirus disease (COVID-19) in Hubei Province, China date: 2020-04-19 words: 3605 flesch: 42 summary: The mean age (SD) of COVID-19 suspected patients was 43.1 (2.6). The mean age (SD) of COVID-19 suspected patients was 43.1 (2.6). keywords: covid-19; group; health; mental; patients; schizophrenia cache: cord-302800-852w35od.txt plain text: cord-302800-852w35od.txt item: #1702 of 2876 id: cord-302806-1e99cygs author: Bozkurt, Banu title: The COVID-19 Pandemic: Clinical Information for Ophthalmologists date: 2020-04-29 words: 3692 flesch: 47 summary: They also stated that for this reason, healthcare workers' compliance with personal protective equipment guidelines (M3G: mask, gown, gloves, and goggles/face shield) is imperative during the examination and treatment of SARS patients. In a study including 22 patients in France, COVID-19 positive patients were given 600 mg of hydroxychloroquine per day for 10 days and it was observed that virus load decreased by 50% when used alone and by up to 100% when used in combination with azithromycin. 37 keywords: 2019; contact; coronavirus; covid-19; disease; examination; novel; patients; samples; sars cache: cord-302806-1e99cygs.txt plain text: cord-302806-1e99cygs.txt item: #1703 of 2876 id: cord-302821-b9ikg0xy author: Gawałko, Monika title: COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications date: 2020-09-01 words: 3693 flesch: 14 summary: (74, 75) Little data are available on the value of rhythm and rate control strategies in AF patients with COVID-19 patients. Here, we review the available evidence for prevalence and incidence of AF in patients infected with the severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) and discuss disease management approaches and potential treatment options for COVID-19 infected AF patients. keywords: ace2; acute; coronavirus; covid-19; disease; fibrillation; infection; patients; sars cache: cord-302821-b9ikg0xy.txt plain text: cord-302821-b9ikg0xy.txt item: #1704 of 2876 id: cord-302862-znnlyz3y author: Lim, Peter A.C. title: Transverse Myelitis date: 2019-04-17 words: 4788 flesch: 32 summary: Comparison of spinal cord presentations of multiple sclerosis Discriminatory features of acute transverse myelitis: a retrospective analysis of 45 patients Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-aquaporin 4 antibodies Acute myelitis due to Zika virus infection Clinical and evoked potential changes in acute transverse myelitis following methyl prednisolone Residual bladder dysfunction 2 to 10 years after acute transverse myelitis Transverse myelitis in children: long-term urological outcomes Involvement of the entire spinal cord and medulla oblongata in acute catastrophic-onset transverse myelitis in SLE Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease Point: should phrenic nerve stimulation be the treatment of choice for spinal cord injury? Effective management of intractable neuropathic pain using an intrathecal morphine pump in a patient with acute transverse myelitis Effects of locomotor training after incomplete spinal cord injury: a systematic review Robot-assisted gait training (Lokomat) improves walking function and activity in people with spinal cord injury: a systematic review Powered exoskeletons for walking assistance in persons with central nervous system injuries: a narrative review Nerve transfers for restoration of upper extremity motor function in a child with upper extremity deficits due to transverse myelitis: case report Spasticity and joint contractures are common complications with spinal cord injury and management may be straightforward or extremely difficult, requiring several interventions simultaneously. keywords: acute; bladder; bowel; cord; devices; level; myelitis; nerve; pain; patient; recovery; spinal; transverse cache: cord-302862-znnlyz3y.txt plain text: cord-302862-znnlyz3y.txt item: #1705 of 2876 id: cord-302864-2xnq1oq7 author: Quartuccio, Luca title: Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care date: 2020-05-15 words: 3186 flesch: 43 summary: To conclude, our study showed that TOCI treated patients COVID-19 pneumonia were at the highest risk of cytokine storm [32] . Aging (Albany NY) Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis Prediction for Progression Risk in Patients with COVID-19 Pneumonia: the CALL Score Clinical Course and Outcomes of Critically Ill Patients With SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study Clinical Characteristics of Coronavirus Disease 2019 in China Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Risk of thrombosis in Sjögren syndrome: the open question of endothelial function immune-mediated dysregulation Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan On the alert for cytokine storm: Immunopathology in COVID-19. keywords: covid-19; cytokine; data; group; patients; study; toci; tocilizumab cache: cord-302864-2xnq1oq7.txt plain text: cord-302864-2xnq1oq7.txt item: #1706 of 2876 id: cord-302997-39o08tt1 author: Ceruti, S. title: Reduced mortality and shorten ICU stay in SARS-COV-2 pneumonia: a low PEEP strategy date: 2020-05-08 words: 3557 flesch: 47 summary: Patients presenting partial respiratory failure combining peripheral saturation (SpO 2 ) lower than 85% and dyspnea (or mental confusion), or patients with dyspnea (or mental confusion) alone, were eligible to be admitted in ICU. During daily screening of the lower limb ultrasound, COVID-19 ICU patients showed a high prevalence rate of DVTs and PEs, even under preventive anticoagulation. keywords: covid-19; icu; license; medrxiv; patients; peep; preprint cache: cord-302997-39o08tt1.txt plain text: cord-302997-39o08tt1.txt item: #1707 of 2876 id: cord-303017-4zx94rm6 author: Barbieri, Antonio title: Can Beta-2-Adrenergic Pathway Be a New Target to Combat SARS-CoV-2 Hyperinflammatory Syndrome?—Lessons Learned From Cancer date: 2020-09-30 words: 3572 flesch: 31 summary: An emerging target of JAK2 inhibitor Fedratinib Distinct immune response in two MERS-CoV-infected patients: Can we go from bench to bedside Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus Molecular mechanisms of b2-adrenergic receptor function, response, and regulation Beta-adrenergic receptors, from their discovery and characterization through their manipulation to beneficial clinical application Autoradiographic visualization of betaadrenoceptor subtypes in human lung Bidirectional role of b2-adrenergic receptor in autoimmune diseases b2-Adrenergic agonists bias TLR-2 and NOD2 activated dendritic cells towards inducing an IL-17 immune response Regulation of Differentiation and Function of Helper T Cells by Lymphocyte-Derived Catecholamines via a 1 -and b 2 -Adrenoceptors Lymphocyte-derived catecholamines induce a shift of Th1/Th2 balance toward Th2 polarization Stress-induced alterations in interferon production and class II histocompatibility antigen expression Nondegradative role of Atg5-Atg12/Atg16L1 autophagy protein complex in antiviral activity of interferon gamma Type I and Type II Interferons Inhibit the Translation of Murine Norovirus Proteins Identification of interferon-g, as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity Enhancement of mouse natural killer cell activity by type II interferon Gammainterferon is one of several direct B cell-maturing lymphokines Distinct Requirements for IFNs and STAT1 in NK Cell Function ILC1 Confer Early Host Protection at Initial Sites of Viral Infection Long acting propranolol and HSP-70 rich tumor lysate reduce tumor growth and enhance immune response against fibrosarcoma in Balb/c mice Propranolol attenuates hemorrhage and accelerates wound healing in severely burned adults Propranolol for disruptive behaviors in nursing home residents with probable or possible Alzheimer disease: A placebo-controlled study Propranolol treatment of assaultive patients with organic brain disease: A double-blind crossover, placebo-controlled study Perioperative inhibition of b-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome Propranolol Attenuates Surgical Stress-Induced Elevation of the Regulatory T Cell Response in Patients Undergoing Radical Mastectomy Perioperative COX-2 and b-Adrenergic Blockade Improves Metastatic Biomarkers in Breast Cancer Patients in a Phase-II Randomized Trial Effect of b-blockers on platelet aggregation: A systematic review and meta-analysis The effects of aspirin and nonselective beta blockade on the acute prothrombotic response to psychosocial stress in apparently healthy subjects Beta-receptor blockade decreases elevated plasma levels of factor VIII: C in patients with deep vein thrombosis Role of endothelial nitric oxide synthase (eNOS) in chronic stress-promoted tumour growth The stress hormone norepinephrine increases migration of prostate cancer cells in vitro and in vivo Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice Anti-IL6R role in treatment of COVID-19-related ARDS Propranolol and the treatment of rheumatoid arthritis The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy b-Adrenergic receptors (b-AR) regulate VEGF and IL-6 production by divergent pathways in high b-AR-expressing breast cancer cell lines Norepinephrine and adenosine-5'-triphosphate synergize in inducing IL-6 production by human dermal microvascular endothelial cells Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: Coronaviruses-drug discovery and therapeutic options The emerging novel Middle East respiratory syndrome coronavirus: The knowns and unknowns Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection Middle East Respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease A novel coronavirus from patients with pneumonia in China Multiple organ infection and the pathogenesis of SARS Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. keywords: adrenergic; beta; blockers; cells; covid-19; il-6; patients; propranolol; response; sars cache: cord-303017-4zx94rm6.txt plain text: cord-303017-4zx94rm6.txt item: #1708 of 2876 id: cord-303054-s1clwunc author: Velly, Lionel title: Guidelines: Anaesthesia in the context of COVID-19 pandemic date: 2020-06-05 words: 9243 flesch: 35 summary: A Narrative Review Evolving status of the 2019 novel coronavirus infection: Proposal of conventional serologic assays for disease diagnosis and infection monitoring Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 Value of Diagnostic Testing for SARS-CoV-2/COVID-19 Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study Epidemiology of COVID-19 Among Children in China Pediatric anesthetic implications of COVID-19-A review of current literature Pediatric Airway Management in COVID-19 patients -Consensus Guidelines from the Society for Pediatric Anesthesia's Pediatric Difficult Intubation Collaborative and the Canadian Pediatric Anesthesia Society Proposal for International Standardization of the Use of Lung Ultrasound for Patients With COVID-19: In addition, some peculiarities of COVID-19 patients (risk of drug interactions, worsening of the condition, etc.) are to be taken into account. keywords: anaesthesia; care; children; consultation; context; cov-2; covid-19; disease; health; infection; intervention; management; mask; pandemic; patient; procedure; risk; sars; surgery; type cache: cord-303054-s1clwunc.txt plain text: cord-303054-s1clwunc.txt item: #1709 of 2876 id: cord-303065-dyg2baog author: Williams, Michael title: Patient-Centered Surgical Care Meets the Social Determinants of Health date: 2020-09-25 words: 908 flesch: 40 summary: Secondary victims of this potential shift in utilization of surgical care will be those patients who are either uninsured or currently qualify for their state's Medicaid program, which provides health insurance for low-income adults and children. The authors have taken an important step in reframing the discussion of surgical care and its value, from the patient's perspective, differing from the preponderance of the literature which often focuses on either physician or health system-centric perspectives, goals and outcomes. keywords: care; health; patients cache: cord-303065-dyg2baog.txt plain text: cord-303065-dyg2baog.txt item: #1710 of 2876 id: cord-303145-rc5luali author: Banach, Maciej title: Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic date: 2020-05-07 words: 2404 flesch: 34 summary: The aim of this document is to share practical recommendations about the management of FH patients and optimisation of their treatment during the COVID-19 pandemic. FH patients are a group with important healthcare needs who require frequent and continued medical attention. keywords: covid-19; cvd; patients; risk; therapy cache: cord-303145-rc5luali.txt plain text: cord-303145-rc5luali.txt item: #1711 of 2876 id: cord-303192-il3s8lgp author: Tam, Lai‐Shan title: Care for patients with rheumatic diseases during COVID‐19 pandemic: A position statement from APLAR date: 2020-05-27 words: 1801 flesch: 20 summary: Rheumatologists need to be vigilant in preventing rheumatic disease patients from contracting the disease during this pandemic, especially patients with chronic lung problems (eg scleroderma with lung fibrosis) and chronic kidney disease (eg lupus nephritis) and those on high-dose glucocorticoids and immunosuppressants (Appendix 1). 6 Globally the quality of evaluation, monitoring and treatment of comorbidities in rheumatic disease patients is variable with considerable scope for improvement. keywords: anti; coronavirus; covid-19; disease; patients; risk; treatment cache: cord-303192-il3s8lgp.txt plain text: cord-303192-il3s8lgp.txt item: #1712 of 2876 id: cord-303244-5tfrmsm7 author: Kugasia, Irfanali R. title: Amiodarone Toxicity Presenting with Acute Onset of Systemic Inflammatory Response Syndrome and Multiorgan Failure Mimicking Sepsis date: 2020-10-23 words: 2398 flesch: 43 summary: We present an unusual case of amiodarone toxicity which manifested with multiorgan failure and systemic inflammatory response syndrome that mimicked sepsis. Herein, we describe an unusual case of amiodarone toxicity that presented with acute onset of fever, multiorgan failure, and systemic inflammatory response syndrome that masqueraded as sepsis from a low cumulative dose of approximately 75 g. A 73-year-old man presented to our hospital in February 2020 with fever and flu-like symptoms of body aches, fatigue, and malaise for 10 days. keywords: acute; amiodarone; patient; toxicities; toxicity cache: cord-303244-5tfrmsm7.txt plain text: cord-303244-5tfrmsm7.txt item: #1713 of 2876 id: cord-303349-0kn7apl3 author: Lippi, Giuseppe title: Hemoglobin value may be decreased in patients with severe coronavirus disease 2019 date: 2020-04-02 words: 876 flesch: 42 summary: key: cord-303349-0kn7apl3 authors: Lippi, Giuseppe; Mattiuzzi, Camilla title: Hemoglobin value may be decreased in patients with severe coronavirus disease 2019 date: 2020-04-02 journal: The final meta-analysis entailed the estimation of the weighted mean difference (WMD) and 95% confidence interval (95% CI) of hemoglobin values between subjects with or without severe disease. keywords: disease; hemoglobin; patients cache: cord-303349-0kn7apl3.txt plain text: cord-303349-0kn7apl3.txt item: #1714 of 2876 id: cord-303363-uu9hb1c9 author: Karimi, Mehran title: Implications of SARSr-CoV 2 infection in thalassemias: Do patients fall into the “high clinical risk” category? date: 2020-05-11 words: 3276 flesch: 31 summary: A first step in understanding SARS pathogenesis Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) -China Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis Clinical features of patients infected with 2019 novel coronavirus in Wuhan Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Beta-thalassemia Prevalence and predictors of cardiac and liver iron overload in patients with thalassemia: A multicenter study based on real-world data A Concise Review on the Frequency, Major Risk Factors and Surveillance of Hepatocellular Carcinoma (HCC) in β-Thalassemias: Past, Present and Future Perspectives and the ICET-A Experience Early Cardiac Involvement and Risk Factors for the Development of Arrhythmia in Patients With β-Thalassemia Major Thyroid Disorders in Homozygous β-Thalassemia: Current Knowledge, Emerging Issues and Open Problems An ICET-A survey on occult and emerging endocrine complications in patients with β-thalassemia major: Conclusions and recommendations SARS-CoV-2 infection in beta thalassemia: preliminary data from the Italian experience Coronavirus Disease 2019: Coronaviruses and Blood Safety The medical concerns of patients with thalassemias at the time of COVID-19 outbreak: The personal experience and the international recommendations THE COVID-19 PANDEMIC AND HAE-MOGLOBIN DISORDERS. Green tea and chamomile, which contain the natural antioxidant, and lastly, probiotics are recommended and beneficial in thalassemia patients against viral infections (29) . keywords: coronavirus; covid-19; disease; immune; infection; iron; patients; risk; sars; thalassemia cache: cord-303363-uu9hb1c9.txt plain text: cord-303363-uu9hb1c9.txt item: #1715 of 2876 id: cord-303460-abutfxtf author: Searle, Tamara title: Screen rhytides: the cosmetic legacy of COVID‐19 date: 2020-08-21 words: 166 flesch: 37 summary: 3 COVID-19 lockdown restrictions necessarily prohibited access to most aesthetic injectable treatments and as cosmetic clinics start to reopen, cosmetic dermatologists are likely to have a backlog of patients. key: cord-303460-abutfxtf authors: Searle, Tamara; Ali, Faisal R.; Al‐Niaimi, Firas title: Screen rhytides: the cosmetic legacy of COVID‐19 date: 2020-08-21 journal: Dermatol Ther DOI: 10.1111/dth.14211 sha: doc_id: 303460 cord_uid: abutfxtf nan contraction may reduce the length of time that botulinum toxin exerts its effects, resulting in an increased demand for more sessions of botulinum toxin with shorter intervals between each treatment. keywords: patients cache: cord-303460-abutfxtf.txt plain text: cord-303460-abutfxtf.txt item: #1716 of 2876 id: cord-303483-wendrxee author: Rubin, Geoffrey D. title: The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society date: 2020-04-07 words: 4318 flesch: 28 summary: Separate ratings were obtained for COVID-19 positive patients and either COVID-19 negative patients or patients for whom COVID-19 testing is unavailable (Fig 2, Q6 & Q7) . For COVID-19 positive patients, imaging establishes baseline pulmonary status and identifies underlying cardiopulmonary abnormalities that may facilitate risk stratification for clinical worsening. keywords: covid-19; disease; imaging; infection; patients; risk; test; testing; transmission cache: cord-303483-wendrxee.txt plain text: cord-303483-wendrxee.txt item: #1717 of 2876 id: cord-303517-8971aq02 author: Cajamarca-Baron, Jairo title: SARS-CoV-2 (COVID-19) in Patients with some Degree of Immunosuppression date: 2020-10-16 words: 9107 flesch: 33 summary: In this review, we will focus on describing the literature on SARS-COV-2 infection in patients with some degree of immunosuppression, other than rheumatological diseases, among these, cancer patients, transplant recipients, primary immunodeficiency, and HIV patients. Therefore, special recommendations should be considered for these patients, such as postponing adjuvant chemotherapy or elective surgery in people with stable cancer, especially in endemic areas, adopting stricter personal protection measures for cancer patients or cancer survivors, and considering stricter surveillance or treatment when cancer patients are infected with SARS-CoV-2. keywords: cancer; cases; china; coronavirus; cov-2; covid-19; disease; immunosuppression; infection; management; patients; response; results; risk; sars; transplant; treatment; use cache: cord-303517-8971aq02.txt plain text: cord-303517-8971aq02.txt item: #1718 of 2876 id: cord-303600-96vtj89w author: Kapoor, Deeksha title: Elective Gastrointestinal Surgery in COVID Times date: 2020-10-22 words: 3571 flesch: 44 summary: Tele-consultations were performed extensively to maintain the line of care and guide the management of surgical patients, especially those with GI cancers. The hospital, being actively involved in treating COVID patients, undertook various measures like setting up a dedicated flu clinic, the segregation of buildings into COVID and non-COVID blocks, the separation of entry/exit, and the complete isolation of the movement circuit for COVID-positive or suspected patients. keywords: cancer; covid; covid-19; pandemic; patients; period; procedures; surgery cache: cord-303600-96vtj89w.txt plain text: cord-303600-96vtj89w.txt item: #1719 of 2876 id: cord-303661-etb19d6y author: Shin, Hyoung-Shik title: Empirical Treatment and Prevention of COVID-19 date: 2020-06-22 words: 4022 flesch: 38 summary: Tenofovir disoproxil fumarate/ emtricitabine (TDF/FTC), which has been prescribed for HIV-infected or hepatitis B virusinfected patients for a long time can be used safely as a short-term medicine for COVID-19 patients. Risk-adapted treatment strategy For COVID-19 patients Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity A review of unfractionated heparin and its monitoring Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics Teicoplanin: an alternative drug for the treatment of COVID-19? keywords: coronavirus; cov-2; covid-19; hypersensitivity; immunity; patients; pneumonia; sars; symptoms; treatment; virus cache: cord-303661-etb19d6y.txt plain text: cord-303661-etb19d6y.txt item: #1720 of 2876 id: cord-303703-ekhwb5xb author: Mash, Bob title: Primary care management of the coronavirus (COVID-19) date: 2020-03-31 words: 3047 flesch: 60 summary: : A descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan Novel Coronavirus Pneumonia Emergency Response Epidemiology Team 2019-nCoV quick reference for health workers Guidelines for case-finding, diagnosis, management and public health response in South Africa Clinical management of suspected or confirmed COVID-19 disease Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected I declare that I have no financial or personal relationships that may have inappropriately influenced me in writing this article. Mild cases can be managed at home with self-isolation, symptomatic treatment and follow-up if the disease worsens. keywords: care; case; covid-19; infection; patients; people; swab cache: cord-303703-ekhwb5xb.txt plain text: cord-303703-ekhwb5xb.txt item: #1721 of 2876 id: cord-303718-7bpap31f author: Binder, Adam F. title: Treating Hematologic Malignancies During a Pandemic: Utilizing Telehealth and Digital Technology to Optimize Care date: 2020-06-26 words: 3124 flesch: 30 summary: Tools for enabling decentralized care include (10) telehealth visits, home based care, and remote patient monitoring. The swift adoption of decentralization strategies like telehealth visits, home-based care, and remote patient monitoring can allow physicians treating hematologic malignancies to maintain care while mitigating the risk of nosocomial SARS-COV-2 infection. keywords: cancer; care; covid-19; home; monitoring; patients; telehealth; treatment; visits cache: cord-303718-7bpap31f.txt plain text: cord-303718-7bpap31f.txt item: #1722 of 2876 id: cord-303787-dx1n8jap author: Vonck, Kristl title: Neurological manifestations and neuro‐invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 date: 2020-05-16 words: 3812 flesch: 33 summary: Viruses Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome A first Case of Meningitis/Encephalitis associated with SARS-Coronavirus-2 Angiotensin-converting enzyme 2 in the brain: Properties and future directions The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Accepted Article The increase in D-Dimer levels appears to be higher in COVID-19 patients with CVD compared to patients without CVD (median levels of 900 microg/l) but this is a finding that will need to be further investigated and documented 3, 9 . keywords: acute; article; copyright; cov-2; covid-19; manifestations; patients; sars; symptoms cache: cord-303787-dx1n8jap.txt plain text: cord-303787-dx1n8jap.txt item: #1723 of 2876 id: cord-303791-yw80ndg6 author: Ashique, Karalikkattil T. title: Teledermatology in the Wake of COVID -19 Scenario: An Indian Perspective date: 2020-05-10 words: 3660 flesch: 45 summary: This helps increase correctness as the instructions can be verbally conveyed at ease to the pharmacy and even alternative medications can be suggested at ease â�¢ WhatsApp business account is one app that can be exploited for teledermatology consultations. The business account also has the advantage of setting automated replies to messages which can be used to convey information, instructions, and disclaimers about teledermatology consultations to anyone who connects. keywords: consultations; covid-19; doctor; india; patient; teledermatology; telemedicine; time cache: cord-303791-yw80ndg6.txt plain text: cord-303791-yw80ndg6.txt item: #1724 of 2876 id: cord-303816-c4z9ys3q author: Xu, YuShuang title: Diagnostic methods and drug therapies in patients with ischemic colitis date: 2020-09-16 words: 5057 flesch: 37 summary: Ischemic colitis (IC) is the most prevalent ischemic injury of thegastrointestinal tract. PubMed and Cochrane Library were searched toretrieve all published studies reporting the diagnostic methods and drugtherapies in patients with ischemic colitis. keywords: acute; colitis; colon; diagnosis; disease; drug; ischemic; patients; risk; studies; treatment cache: cord-303816-c4z9ys3q.txt plain text: cord-303816-c4z9ys3q.txt item: #1725 of 2876 id: cord-303819-w1785lap author: Cortegiani, Andrea title: Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19 date: 2020-07-11 words: 3477 flesch: 47 summary: Evidence from available data suggests that monitoring baseline and subsequent (e.g. daily) ECG during treatment especially in high risk patients with known risk. Although this trial seems appropriately powered and has a low risk of bias, delayed initiation of treatment (usually ≥3 days) and the use of self-reported outcomes make it Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review Hydroxychloroquine in the management of patients with COVID-19: the need for an evidence base A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 Chloroquine for COVID-19: rationale, facts, hopes Including non-randomized studies on intervention effects RoB 2: A revised tool for assessing risk of bias in randomised trials ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing risk-of-bias assessments Synthesizing and presenting findings using other methods | Cochrane Training A pilot study of hydroxychloroquine in coronavirus disease-19 (COVID-19) Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19 Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Early J o u r n a l P r e -p r o o f treatment of COVID-19 patients with hydroxychloroquine and azithromycin: keywords: covid-19; hcq; hydroxychloroquine; patients; risk; studies; treatment cache: cord-303819-w1785lap.txt plain text: cord-303819-w1785lap.txt item: #1726 of 2876 id: cord-303860-jpy373ph author: Huang, Zhifeng title: Occupational Exposure to SARS-CoV-2 in Burns Treatment During the COVID-19 Epidemic: Specific Diagnosis and Treatment Protocol date: 2020-04-23 words: 3086 flesch: 41 summary: Following an in-depth study of the latest literature on COVID-19 diagnosis and treatment, we reviewed the protocols surrounding hospitalization of patients with extensive burns in our hospital and, in accordance with the epidemiological characteristics of COVID-19, developed an algorithm for protection during diagnosis and treatment of burn patients. Because of systemic inflammatory response syndrome and large amount of rehydration treatment, burn patients are prone to pulmonary edema. keywords: coronavirus; covid-19; healthcare; infection; patients; protection; treatment cache: cord-303860-jpy373ph.txt plain text: cord-303860-jpy373ph.txt item: #1727 of 2876 id: cord-303880-zv4nbz9p author: Tsikala Vafea, Maria title: Emerging Technologies for Use in the Study, Diagnosis, and Treatment of Patients with COVID-19 date: 2020-06-24 words: 5492 flesch: 39 summary: 19 Re-cently, deep learning models, the core algorithms of AI, have been used to develop a thoracic CT image analysis system, which can automatically detect COVID-19 patients and quantify the disease burden. Frontline healthcare practitioners, including CT and MRI technicians, are at high risk for contracting the virus given their frequent exposure to COVID-19 patients. keywords: coronavirus; covid-19; data; development; disease; health; learning; models; pandemic; patients; sars; use; vaccine; virus cache: cord-303880-zv4nbz9p.txt plain text: cord-303880-zv4nbz9p.txt item: #1728 of 2876 id: cord-304010-n4gxxl5i author: Sung, Ho Kyung title: Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January–May 2020 date: 2020-07-28 words: 3423 flesch: 52 summary: World Health Organization Estimates of the severity of coronavirus disease 2019: a model-based analysis Korean Society of Infectious Diseases; Korean Society of Pediatric Infectious Diseases Report on the epidemiological features of coronavirus disease 2019 (COVID-19) outbreak in the Clinical Outcomes of COVID-19 Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Remdesivir for the treatment of Covid-19 -Preliminary report Operating protocols of a community treatment center for isolation of patients with coronavirus disease Clinical course of asymptomatic and mildly symptomatic patients with coronavirus disease admitted to community treatment centers Observational study of hydroxychloroquine in hospitalized patients with Covid-19 A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 Towards a better response to the next wave of the pandemic, the clinical course and outcomes of COVID-19 patients need to be defined. keywords: age; covid-19; need; oxygen; patients; therapy cache: cord-304010-n4gxxl5i.txt plain text: cord-304010-n4gxxl5i.txt item: #1729 of 2876 id: cord-304090-l5rocsk5 author: Akbar, Aelia title: A Cross-Sectional Survey on Telemedicine Use for Doctor-Patient Communication date: 2020-09-12 words: 2730 flesch: 49 summary: Patient characteristics, computer use and prior use of patient portal did not affect their opinion about health questions being answered prior to their visit. The opinion about use of health app by doctors to professionally evaluate health conditions did not differ by patient characteristics, frequency of computer use or use of patient portal, but it differed by education level. keywords: communication; computer; health; patient; use cache: cord-304090-l5rocsk5.txt plain text: cord-304090-l5rocsk5.txt item: #1730 of 2876 id: cord-304248-sxbyxnxn author: Aiolfi, Alberto title: MANAGEMENT OF PERSISTENT PNEUMOTHORAX WITH THORACOSCOPY AND BLEBS RESECTION IN COVID-19 PATIENTS date: 2020-04-27 words: 772 flesch: 41 summary: Drains were removed on POD 2. Reports on imaging findings of COVID-19 patients are now emerging [3] . As described for ARDS, lungs of COVID-19 patients with significant interstitial involvement, seem physiologically small with low compliance and reduced elastance. keywords: patients; pneumothorax cache: cord-304248-sxbyxnxn.txt plain text: cord-304248-sxbyxnxn.txt item: #1731 of 2876 id: cord-304255-7xs9cit7 author: Parrish, Richard K. title: What Does Telemedicine Mean for the Care of Patients With Glaucoma in the Age of COVID-19? date: 2020-08-13 words: 899 flesch: 45 summary: 7 Technologies may be improving our ability to care for glaucoma patients; however, 'laying on of hands' will not likely be replaced by 'laying on of digital images' in the immediate future without better tools, better access, and guaranteed benefit for all patients. The 'silent thief' begins to tell its secrets Telemedicine for glaucoma: guideline and recommendation Self-tonometry as a complement in the investigation of glaucoma patients keywords: glaucoma; patients; telemedicine cache: cord-304255-7xs9cit7.txt plain text: cord-304255-7xs9cit7.txt item: #1732 of 2876 id: cord-304271-vyayyk50 author: Qin, Yuan-Yuan title: Effectiveness of glucocorticoid therapy in patients with severe coronavirus disease 2019: protocol of a randomized controlled trial date: 2020-03-05 words: 3999 flesch: 31 summary: [2] However, other coronaviruses, such as those associated with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), may cause severe respiratory disease, and have caused a total of more than 10,000 laboratory-confirmed cases globally in the past two decades, with a 10% and 34.4% case-fatality rate, respectively. Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 6) 2020 The Third International Consensus definitions for sepsis and septic shock (Sepsis-3) Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong Development of a standard treatment protocol for severe acute respiratory syndrome High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome A major outbreak of severe acute respiratory syndrome in Hong Kong A cluster of cases of severe acute respiratory syndrome in Hong Kong keywords: acute; coronavirus; glucocorticoid; patients; sars; study; syndrome; therapy; treatment cache: cord-304271-vyayyk50.txt plain text: cord-304271-vyayyk50.txt item: #1733 of 2876 id: cord-304280-2a84u4tm author: Masic, Izet title: Public Health Aspects of COVID-19 Infection with Focus on Cardiovascular Diseases date: 2020-03-17 words: 4697 flesch: 37 summary: Then, a few days ago, French researchers showed in a very small group of patients that the concomitant administration of hydroxychloroquine and azithromycin (Sumamed) had an even better effect in COVID-19 patients. Published case reports from the Chinese Centers for Disease Control indicate patients with underlying comorbid conditions have a heighted risk for contracting COVID-19 and a worse prognosis; depending on the report, between 25% and 50% of COVID-19 patients present with underlying conditions. keywords: care; covid-19; disease; health; infection; pandemic; patients; risk; sars; treatment; virus cache: cord-304280-2a84u4tm.txt plain text: cord-304280-2a84u4tm.txt item: #1734 of 2876 id: cord-304321-y177sqee author: Cho, Ryan H. W. title: Pearls of experience for safe and efficient hospital practices in otorhinolaryngology—head and neck surgery in Hong Kong during the 2019 novel coronavirus disease (COVID-19) pandemic date: 2020-05-15 words: 4380 flesch: 39 summary: Moreover, COVID-19 patients as young as 3 days have been reported [23] . Recommendations on implementing isolation precautions in hospital settings Rational use of personal protective equipment for coronavirus disease (COVID-19): Interim guidance Considerations for recommending extended use and limited reuse of filtering facepiece respirators in health care settings Recovering the infective route of super-spreaders SARS-CoV-2 viral load in upper respiratory specimen of infected patients Suggestions for prevention of 2019 novel coronavirus infection in otolaryngology head and neck surgery medical staff Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Tracheostomy during SARS Tumor progression in waiting time for radiotherapy in head and neck cancer Recurrent thyroid cancer: role of surgery versus radioactive iodine Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement A case report of neonatal COVID-19 infection in China A case series of children with 2019 novel coronavirus infection: clinical and epidemiological features Successful telemedicine programs in otolaryngology Validation study of portable device for the diagnosis of obstructive sleep apnea according to the new AASM scoring criteria: Watch-PAT 100 Diagnosis of obstructive sleep apnea by peripheral arterial tonometry: meta-analysis Infection control in audiological practice Infection prevention and control guidelines for audiology Health care workers are at high risk of catching COVID-19. keywords: cases; china; coronavirus; covid-19; healthcare; hospital; infection; pandemic; patients; personnel; procedures; sars cache: cord-304321-y177sqee.txt plain text: cord-304321-y177sqee.txt item: #1735 of 2876 id: cord-304399-7t2mu13s author: Wynne, Keona Jeane title: Dying individuals and suffering populations: applying a population-level bioethics lens to palliative care in humanitarian contexts: before, during and after the COVID-19 pandemic date: 2020-06-19 words: 12083 flesch: 40 summary: Based on this logic, if human and material resources are scarce, those patients triaged as expectant will not be allocated palliative care resources in order to maximise the quality life years or utility for individuals for whom curative interventions are an option. key: cord-304399-7t2mu13s authors: Wynne, Keona Jeane; Petrova, Mila; Coghlan, Rachel title: Dying individuals and suffering populations: applying a population-level bioethics lens to palliative care in humanitarian contexts: before, during and after the COVID-19 pandemic date: 2020-06-19 journal: J Med Ethics DOI: 10.1136/medethics-2019-105943 sha: doc_id: 304399 cord_uid: 7t2mu13s BACKGROUND: Humanitarian crises and emergencies, events often marked by high mortality, have until recently excluded palliative care—a specialty focusing on supporting people with serious or terminal illness or those nearing death. keywords: bioethics; care; covid-19; crises; dying; emergencies; emergency; euthanasia; groups; guide; health; level; life; palliative; pandemic; patients; population; resources; response cache: cord-304399-7t2mu13s.txt plain text: cord-304399-7t2mu13s.txt item: #1736 of 2876 id: cord-304418-k9owyolj author: Le Maréchal, M. title: COVID-19 in clinical practice: a narrative synthesis date: 2020-09-29 words: 6303 flesch: 43 summary: Thromboembolic complications Several works have described the high incidence in COVID-19 patients of both venous and arterial thromboembolic diseases. Cardiac injuries have been described in COVID-19 patients. keywords: cases; china; coronavirus; covid-19; days; disease; group; infection; patients; remdesivir; sars; study; syndrome; treatment; viral cache: cord-304418-k9owyolj.txt plain text: cord-304418-k9owyolj.txt item: #1737 of 2876 id: cord-304457-8g36h1bz author: Idelsis, E.-M. title: Effect and safety of combination of interferon alpha-2b and gamma or interferon alpha-2b for negativization of SARS-CoV-2 viral RNA. Preliminary results of a randomized controlled clinical trial. date: 2020-08-01 words: 5864 flesch: 40 summary: Negativization for HeberFERON treated patients was related to a significant increase in lymphocytes counts and an also significant reduction in CRP as early as 7 days after commencing the therapeutic schedule. Earlier increase in lymphocytes percentage was observed only for HeberFERON treated patients (p=0.0141) with a marked trend for increment in lymphocytes concentrations. keywords: clinical; cov-2; covid-19; group; heberferon; ifn; medrxiv; patients; preprint; sars; treatment; trial cache: cord-304457-8g36h1bz.txt plain text: cord-304457-8g36h1bz.txt item: #1738 of 2876 id: cord-304474-hfv43e9m author: Marchese, Valentina title: Strongyloides infection manifested during immunosuppressive therapy for SARS-CoV-2 pneumonia date: 2020-09-10 words: 2395 flesch: 34 summary: Pneumonia: a systematic review of the literature Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 Pneumonia in Wuhan Dexamethasone in hospitalized patients with Covid-19-preliminary report Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: a single center Tocilizumab in patients with severe COVID-19: a retrospective cohort study ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors) To date, no case of strongyloidiasis related to severe COVID-19 treatment has been reported. keywords: covid-19; infection; patients; strongyloides; strongyloidiasis; tocilizumab; treatment cache: cord-304474-hfv43e9m.txt plain text: cord-304474-hfv43e9m.txt item: #1739 of 2876 id: cord-304479-uxp1kg86 author: Goodarzi, Pedram title: Coronavirus disease 2019 (COVID-19): Immunological approaches and emerging pharmacologic treatments date: 2020-08-08 words: 8115 flesch: 35 summary: Furthermore, there are some open clinical trials for the therapeutic assessment of methylprednisolone on COVID-19 patients [57] . [58] , shows that at least six different published studies on the effect of corticosteroids on COVID-19 patients. keywords: antiviral; cells; convalescent; coronavirus; cov-2; covid-19; disease; human; infection; patients; plasma; pneumonia; remdesivir; sars; study; therapy; treatment cache: cord-304479-uxp1kg86.txt plain text: cord-304479-uxp1kg86.txt item: #1740 of 2876 id: cord-304573-3nhglbw4 author: Bola, Sumrit title: COVID-19 and the return to head and neck outpatient activity in the United Kingdom: what is the new normal? date: 2020-11-06 words: 3407 flesch: 46 summary: Realising that some NHS Trust may have remote sites for outpatient clinics, entries were only excluded from the study if the place of work and data entry were identical. All otolaryngology survey responders were still performing flexible nasendoscopy (FNE) in outpatient clinic whilst 5 non-otolaryngologist reported that FNE was no longer performed due to safety concerns or an unsuitable room. keywords: clinic; nasendoscopy; outpatient; patients; responders; room cache: cord-304573-3nhglbw4.txt plain text: cord-304573-3nhglbw4.txt item: #1741 of 2876 id: cord-304593-cugypxp0 author: Dhillon, M. S. title: Changing Pattern of Orthopaedic Trauma Admissions During COVID-19 Pandemic: Experience at a Tertiary Trauma Centre in India date: 2020-08-28 words: 3017 flesch: 48 summary: Implementation of lockdown led to remarkable decline in public mobility, which was hypothesised, would affect the epidemiology and profile of trauma patients presenting to the orthopaedic department. We could discern almost a doubling of trauma patients once the strict phase of the first lockdown was over, with road accidents becoming more than three times the number as compared to lockdown 1. keywords: day; lockdown; number; patients; phase; trauma cache: cord-304593-cugypxp0.txt plain text: cord-304593-cugypxp0.txt item: #1742 of 2876 id: cord-304601-e6qlx1r6 author: Garcez, Flavia Barreto title: Delirium and adverse outcomes in hospitalized patients with COVID‐19. date: 2020-08-24 words: 3486 flesch: 36 summary: We found that even after these adjustments, delirium remained an independent predictor of adverse outcomes in the hospital, underlining its role as a prognostic marker in COVID-19 patients. We identified delirium occurrence using the Chart‐based Delirium Identification Instrument (CHART‐DEL). keywords: article; care; covid-19; delirium; hospital; outcomes; patients; rights cache: cord-304601-e6qlx1r6.txt plain text: cord-304601-e6qlx1r6.txt item: #1743 of 2876 id: cord-304602-jpxjiaru author: Anneser, Johanna title: Dying patients with COVID-19: What should Hospital Palliative Care Teams (HPCTs) be prepared for? date: 2020-06-23 words: 1656 flesch: 51 summary: Many physicians and nurses in ordinary wards may be unfamiliar with the treatment of dying patients, and their workload is immense during a pandemic wave. SIGNIFICANCE OF RESULTS: COVID-19 patients who are not eligible for ICU treatment may have a particularly high need for palliative care. keywords: care; covid-19; palliative; patients cache: cord-304602-jpxjiaru.txt plain text: cord-304602-jpxjiaru.txt item: #1744 of 2876 id: cord-304791-wv4qu9xm author: Carfora, Vincenzo title: Anticoagulant treatment in COVID-19: a narrative review date: 2020-08-18 words: 3579 flesch: 34 summary: To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) Outcomes in patients with hyperglycemia affected by COVID-19: can we do more on glycemic control? Lille ICU Haemostasis COVID-19 group (2020) Pulmonary embolism in COVID-19 patients: awareness of an increased prevalence Pulmonary post-mortem findings in a large series of COVID-19 cases from Northern Italy Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study D-dimer is associated with severity of coronavirus disease 2019 (COVID-19): a pooled analysis Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19) ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) Inflammation and thrombosis: the clot thickens Dysregulation of immune response in patients with COVID-19 in Wuhan, China The role of inflammation in venous thromboembolism Proteinase activated receptors in fibroproliferative lung disease Coagulation cascade proteinases in lung injury and fibrosis Will complement inhibition be the new target in treating COVID-19 related systemic thrombosis? Effective treatment of severe COVID-19 patients with tocilizumab Eculizumab treatment in patients with COVID-19: preliminary results from real life ASL Napoli 2 keywords: activation; cascade; complement; coronavirus; covid-19; disease; patients; pulmonary; sars; state cache: cord-304791-wv4qu9xm.txt plain text: cord-304791-wv4qu9xm.txt item: #1745 of 2876 id: cord-304798-j2tyjo1j author: Rapkiewicz, Amy V. title: Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series date: 2020-06-25 words: 5322 flesch: 37 summary: A recent autopsy series of COVID-19 cases incorporating endothelial electron microscopy demonstrated ultrastructural endothelial damage and increased angiogenesis as compared to cases of fatal influenza, with differential regulation of genes related to angiogenesis and inflammation [24] . Troponin elevation is common in COVID-19 patients and is associated with increased risk of death keywords: cardiac; cases; covid-19; disease; heart; megakaryocytes; patients; platelet; pulmonary; series; thrombi; thrombosis cache: cord-304798-j2tyjo1j.txt plain text: cord-304798-j2tyjo1j.txt item: #1746 of 2876 id: cord-304949-mf3utolt author: Porzio, Giampiero title: Home Care for Cancer Patients During COVID-19 Pandemic: The Double Triage Protocol date: 2020-03-31 words: 1326 flesch: 46 summary: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study who-director-general-s-openingremarks-at-the-media-briefing-on-covid Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Cancer care after natural disaster: different countries, similar problems Home care for cancer patients after an earthquake: the experience of the 'L'Aquila per la Vita' Home Care Unit Italian Ministry of Health recommendations for 'case' definition The PERSONS score for symptoms assessment in simultaneous care setting: a pilot study The PERSONS score: a new tool for cancer patients' symptom assessment in simultaneous care and home care settings Successful validation of the palliative prognostic score in terminally ill cancer patients. At that time, there was availability of neither literature data nor previously published experiences related to oncological home care during natural disasters. keywords: cancer; care; home; patients cache: cord-304949-mf3utolt.txt plain text: cord-304949-mf3utolt.txt item: #1747 of 2876 id: cord-304972-aktfbriw author: Cots, Josep M. title: Recommendations for Management of Acute Pharyngitis in Adults date: 2015-06-30 words: 6005 flesch: 45 summary: This benefit was greater for adult patients, those with greater symptomatology and those with streptococcal AP. These tests offer the advantage of diagnosing streptococcal AP in a few minutes, with an associated specificity greater than 95% when used in patients with 2 or more Centor criteria. keywords: acute; antibiotics; criteria; gabhs; group; patients; pharyngitis; streptococcal; symptoms; throat; treatment; use cache: cord-304972-aktfbriw.txt plain text: cord-304972-aktfbriw.txt item: #1748 of 2876 id: cord-305076-v56y5nyt author: Singh, Parmvir title: Disseminated Intravascular Coagulation: A Devastating Systemic Disorder of Special Concern with COVID‐19 date: 2020-07-23 words: 2914 flesch: 39 summary: 1, 8, 9 They are elevated in 40% of critically ill patients, 80% of trauma patients, and nearly 100% of DIC patients. The hypercoagulable state of DIC results in microvascular occlusion beginning distally and advancing proximally. keywords: coagulation; covid-19; dic; fulminans; gangrene; patients; purpura; skin cache: cord-305076-v56y5nyt.txt plain text: cord-305076-v56y5nyt.txt item: #1749 of 2876 id: cord-305134-s7h6bpof author: Mackman, Nigel title: Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses date: 2020-07-13 words: 6427 flesch: 35 summary: Pulmonary thrombosis and microvascular thrombosis are observed in autopsy studies, and this may contribute to the severe hypoxia observed in COVID-19 patients. It is likely that multiple systems contribute to thrombosis in COVID-19 patients, such as activation of coagulation, platelet activation, hypofibrinolysis, endothelial cell dysfunction, inflammation, neutrophil extracellular traps, and complement. keywords: activation; acute; cells; coagulation; coronavirus; covid-19; infection; lung; patients; sars; study; syndrome; thrombosis cache: cord-305134-s7h6bpof.txt plain text: cord-305134-s7h6bpof.txt item: #1750 of 2876 id: cord-305139-851v2qr3 author: Peys, Elise title: Haemoptysis as the first presentation of COVID-19: a case report date: 2020-10-22 words: 2558 flesch: 49 summary: Among COVID-19 patients, fever, cough and fatigue are the most commonly reported clinical symptoms. The role of bronchoscopy in COVID-19 patients during the SARS-CoV-2 pandemic Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations keywords: case; cov-2; covid-19; haemoptysis; patient; range; reference cache: cord-305139-851v2qr3.txt plain text: cord-305139-851v2qr3.txt item: #1751 of 2876 id: cord-305205-ilxxkm0f author: Cochennec, Frédéric title: Impact of intraoperative adverse events during branched and fenestrated aortic stent grafting on postoperative outcome date: 2014-09-30 words: 2943 flesch: 37 summary: Impact of intraoperative adverse events during branched and fenestrated aortic stent grafting on postoperative outcome Fenestrated and branched endovascular aneurysm repairs (FEVAR and BEVAR) have become an attractive alternative to open repair for complex abdominal aortic aneurysms (CAAAs) and thoracoabdominal aortic aneurysms (TAAAs). It is likely that continuous improvements in endovascular and imaging technologies will improve the safety of complex endovascular aortic procedures. keywords: aneurysms; aortic; branched; complications; ioaes; patients; stent cache: cord-305205-ilxxkm0f.txt plain text: cord-305205-ilxxkm0f.txt item: #1752 of 2876 id: cord-305283-1bg1ykui author: ElSeirafi, Mohamed MA. title: Efficacy and safety of tocilizumab in critically ill adults with COVID-19 infection in Bahrain: A report of 5 cases date: 2020-06-23 words: 1917 flesch: 44 summary: Tocilizumab: A Review in Rheumatoid Arthritis Clinical outcomes in COVID-19 patients treated with tocilizumab: An individual patient data systematic review The Covid Irccs Tocilizumab for treatment of severe COVID-19 patients: Preliminary results from SMAtteo COvid19 REgistry (SMACORE). We observed in the present study that COVID-19 patients with severe lung injury responded dramatically following the introduction of tocilizumab. keywords: covid-19; lung; patient; therapy; tocilizumab cache: cord-305283-1bg1ykui.txt plain text: cord-305283-1bg1ykui.txt item: #1753 of 2876 id: cord-305304-d3x734nu author: Birnbaum, Yochai title: Inferior ST-Elevation Myocardial Infarction Presenting When Urgent Primary Percutaneous Coronary Intervention Is Unavailable: Should We Adhere to Current Guidelines? date: 2020-07-15 words: 3732 flesch: 38 summary: A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients Inferior myocardial infarction. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group Is thrombolytic therapy really better than conventional treatment in acute inferior myocardial infarction? Randomized comparison of coronary thrombolysis achieved with double-bolus reteplase (recombinant plasminogen activator) and front-loaded, accelerated alteplase (recombinant tissue plasminogen activator) in patients with acute myocardial infarction. keywords: elevation; infarction; level; patients; stemi; study; therapy cache: cord-305304-d3x734nu.txt plain text: cord-305304-d3x734nu.txt item: #1754 of 2876 id: cord-305397-4dx3q6o6 author: Ashraf, Muddasir title: Seizures Related to Coronavirus Disease (COVID-19): Case Series and Literature Review date: 2020-07-24 words: 1872 flesch: 53 summary: We present three cases of COVID-19 patients with seizures. The development of headaches, encephalitis, strokes, and epileptic seizures are among the many neurological symptoms that are manifesting within COVID-19 patients [1] . keywords: covid-19; disease; patient; seizures cache: cord-305397-4dx3q6o6.txt plain text: cord-305397-4dx3q6o6.txt item: #1755 of 2876 id: cord-305405-me4gebvm author: Conway, J. title: Characteristics of patients with diabetes hospitalised for COVID-19 infection-a brief case series report date: 2020-09-21 words: 3187 flesch: 45 summary: The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) -China Impact of diabetes mellitus on clinical outcomes in patients affected by Covid-19 Outcomes in Patients With Hyperglycemia Affected by COVID-19: Can We Do More on Glycemic Control? Hyperglycaemia on admission to hospital and COVID-19 Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? key: cord-305405-me4gebvm authors: Conway, J.; Gould, A.; Westley, R.; Raju, S.; Oklopcic, A.; Broadbent, A.; Abdelhafiz, AH.; Sinclair, AJ. title: Characteristics of patients with diabetes hospitalised for COVID-19 infection-a brief case series report date: 2020-09-21 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108460 sha: doc_id: 305405 cord_uid: me4gebvm Objectives Diabetes has been shown to be a risk factor for corona virus disease-2019 (COVID-19) infection. keywords: cohort; covid-19; diabetes; infection; patients; risk; study cache: cord-305405-me4gebvm.txt plain text: cord-305405-me4gebvm.txt item: #1756 of 2876 id: cord-305422-t8azymo7 author: Yi, Ye title: COVID-19: what has been learned and to be learned about the novel coronavirus disease date: 2020-03-15 words: 8317 flesch: 47 summary: In SARS patients, it has been demonstrated that fever (99%-100%), dry cough (29%-75%), dyspnea (40%-42%), diarrhea (20-25%), and sore throat (13-25%) were the major symptoms and ventilation support was required for approximately 14%-20% of the patients [45] . Cardiac events were also the main reason for death in SARS patients [55, 65, 99] . keywords: acute; cases; china; coronavirus; cov-2; covid-19; disease; human; infection; mers; novel; outbreak; patients; sars; study; syndrome; treatment cache: cord-305422-t8azymo7.txt plain text: cord-305422-t8azymo7.txt item: #1757 of 2876 id: cord-305479-o47mv4uw author: Feng, Xiaobo title: Clinical Characteristics and Short-Term Outcomes of Severe Patients With COVID-19 in Wuhan, China date: 2020-08-06 words: 3639 flesch: 45 summary: In addition, univariate and multivariate Cox analyses of potential factors for poor outcome patients indicated that cytokine storms and uncontrolled inflammation responses as well as liver, kidney, and cardiac dysfunction are related to the development of a poor outcome. Previous studies have shown that 20% of COVID-19 patients developed critical disease due to hypoxia or respiratory failure. keywords: characteristics; clinical; coronavirus; covid-19; group; outcome; patients; study cache: cord-305479-o47mv4uw.txt plain text: cord-305479-o47mv4uw.txt item: #1758 of 2876 id: cord-305498-8tmtvw1r author: Singh Saraj, K. title: Modification of Neurosurgical Practice during Corona Pandemic: Our Experience at AIIMS Patna And Long Term Guidelines date: 2020-09-10 words: 4195 flesch: 58 summary: Neurosurgery department formulated their own strategy for successful and covid free management of neurosurgical patients along with zero transmission rate among doctors and staff. Here we are discussing our department response, guidelines, drawbacks and analysis of one of the most important emergency services at AIIMS Patna with safe execution and management of neurosurgical patients. keywords: cases; covid; department; emergency; neurosurgical; pandemic; patients; period; residents cache: cord-305498-8tmtvw1r.txt plain text: cord-305498-8tmtvw1r.txt item: #1759 of 2876 id: cord-305520-7gxmdo56 author: Lim, Wei Sing title: Widefield imaging with Clarus fundus camera vs slit lamp fundus examination in assessing patients referred from the National Health Service diabetic retinopathy screening programme date: 2020-10-20 words: 3845 flesch: 44 summary: Virtual clinics could indeed help to meet the increased demand for hospital eye clinic appointments as Lee et al. showed that twice as many patients can be seen in virtual clinics compared to slit lamp examination clinics in the same time period [4] . One patient was assessed by the virtual grader to need intravitreal anti-VEGF for diabetic Comparing diabetic retinopathy grading between virtual examination and clinical examination Table 3 shows how the diabetic retinopathy grading performed after Clinical examination (slit lamp examination and OCT) correlates with that done virtually with Clarus fundus photos and OCT (A, B) . keywords: diabetic; examination; face; fundus; imaging; patients; retinopathy cache: cord-305520-7gxmdo56.txt plain text: cord-305520-7gxmdo56.txt item: #1760 of 2876 id: cord-305534-936peb1n author: Johnson, Kemmian D. title: Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19 date: 2020-08-13 words: 6730 flesch: 34 summary: The main reason for the development of these symptoms is the presence of severe pneumonia in COVID-19 patients. However, the pulmonary symptoms can vary in COVID-19 patients, possibly due to variation in severity of disease at the time of presentation. keywords: acute; coronavirus; cov-2; covid-19; disease; injury; manifestations; patients; sars; study; syndrome cache: cord-305534-936peb1n.txt plain text: cord-305534-936peb1n.txt item: #1761 of 2876 id: cord-305582-3hmsknon author: Li, Lei title: Therapeutic strategies for critically ill patients with COVID-19 date: 2020-04-20 words: 6194 flesch: 35 summary: Available drug options that come from the clinical experience of treating SARS, MERS and other previous influenza virus have been used for the treatment of COVID-19 patients. Considering the high incidence of bacterial infection for critically ill patients with COVID-19, it is essential to test the kinetics of procalcitonin (PCT) and C-reaction protein (CRP) in COVID-19 patients for timely diagnosis and intervention of bacterial infection. keywords: 2019; acute; antiviral; coronavirus; covid-19; infection; influenza; ncov; patients; sars; syndrome; therapy; treatment; ventilation cache: cord-305582-3hmsknon.txt plain text: cord-305582-3hmsknon.txt item: #1762 of 2876 id: cord-305650-su6furzi author: Sud, Karan title: Echocardiographic Findings in COVID-19 Patients with Significant Myocardial Injury date: 2020-06-05 words: 566 flesch: 31 summary: key: cord-305650-su6furzi authors: Sud, Karan; Vogel, Birgit; Bohra, Chandrashekar; Garg, Vaani; Talebi, Soheila; Lerakis, Stamatios; Narula, Jagat; Argulian, Edgar title: Echocardiographic Findings in COVID-19 Patients with Significant Myocardial Injury date: 2020-06-05 journal: J Am Soc Echocardiogr DOI: 10.1016/j.echo.2020.05.030 sha: doc_id: 305650 cord_uid: su6furzi nan Myocardial injury has been commonly described in COVID-19 patients, and has been suggested to have prognostic significance.(1) The population was selected from the total number of COVID-19 patients admitted to our hospital during this time period. keywords: covid-19; patients cache: cord-305650-su6furzi.txt plain text: cord-305650-su6furzi.txt item: #1763 of 2876 id: cord-305786-06dpjik8 author: Sandora, Thomas J. title: Pneumonia in Hospitalized Children date: 2005-07-09 words: 7824 flesch: 29 summary: In developing countries, which account for more than 95% of episodes of clinical pneumonia worldwide, researchers estimate that more than 150 million new cases occur annually in children younger than 5 years [4] . Lower respiratory tract illness in the first year of life Pneumonia: an eleven-year study in a pediatric practice Global estimate of the incidence of clinical pneumonia among children under five years of age Practice guidelines for the management of community-acquired pneumonia in adults: Infectious Diseases Society of America Community-acquired pneumonia in children Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children Guidelines for the management of community acquired pneumonia in childhood Role of different routes of tracheal colonization in the development of pneumonia in patients receiving mechanical ventilation Acute respiratory infections Diagnosis and interventions in lower respiratory tract infections keywords: age; cases; chest; children; community; diagnosis; effusions; hospital; infection; patients; pneumonia; study; therapy; treatment cache: cord-305786-06dpjik8.txt plain text: cord-305786-06dpjik8.txt item: #1764 of 2876 id: cord-305838-i0ck2oo0 author: Kouri, Andrew title: CHEST Reviews: Addressing reduced laboratory-based pulmonary function testing during a pandemic date: 2020-07-08 words: 4890 flesch: 28 summary: [17] [18] [19] [20] Access to reliable pulmonary function data is particularly critical for lung transplant patients when weekly monitoring with spirometry is the gold standard care during the first 3 months post-transplant when the risk of acute graft rejection is highest. In asthma care, mHealth applications supporting patient self-management through education, medication reminders, symptom monitoring, and action plan provision have been shown to improve asthma control, medication and action plan adherence, and quality of life. keywords: asthma; copd; diagnosis; function; lung; management; oscillometry; patients; pulmonary; spirometry; testing cache: cord-305838-i0ck2oo0.txt plain text: cord-305838-i0ck2oo0.txt item: #1765 of 2876 id: cord-305959-x061q8t7 author: Davoudi-Monfared, Effat title: A Randomized Clinical Trial of the Efficacy and Safety of Interferon β-1a in Treatment of Severe COVID-19 date: 2020-08-20 words: 4746 flesch: 46 summary: In this randomized clinical trial, the efficacy and safety of IFN ␤-1a were evaluated in patients with severe COVID-19. The present study was the first randomized, open-label, controlled trial that assessed the efficacy and safety of IFN ␤-1a in the treatment of patients diagnosed with severe COVID-19. keywords: clinical; control; covid-19; group; ifn; interferon; mortality; patients; study; treatment cache: cord-305959-x061q8t7.txt plain text: cord-305959-x061q8t7.txt item: #1766 of 2876 id: cord-306016-2gudro8v author: Pelt, Christopher E. title: The Rapid Response to the COVID-19 Pandemic by the Arthroplasty Divisions at Two Academic Referral Centers date: 2020-04-21 words: 3754 flesch: 39 summary: Finally, this 129 approach failed to account for the urgent/complex cases that may have warranted surgery more 130 expediently than other patients due to the potential for ongoing and/or irreversible damage with 131 prolonged delay. In order to ensure and provide for adequate health care resources in terms of hospital capacity, personnel and personal protective equipment (PPE), service lines such as adult reconstruction and lower limb arthroplasty have stopped or substantially limited elective surgeries and have been forced to re-engineer care processes for a high-volume of patients. keywords: arthroplasty; care; covid-19; elective; health; pandemic; patients; surgery cache: cord-306016-2gudro8v.txt plain text: cord-306016-2gudro8v.txt item: #1767 of 2876 id: cord-306062-g9hk1iq5 author: Silverman, Dustin A. title: Respiratory and pulmonary complications in head and neck cancer patients: Evidence‐based review for the COVID‐19 era date: 2020-04-30 words: 4748 flesch: 32 summary: Complications resulting from COVID-19 infection are significant, and immunocompromised patients, including cancer patients, appear particularly susceptible. Cancer patients and immunocompromised hosts are particularly susceptible to lung infection. keywords: aspiration; cancer; head; hnscc; mortality; neck; patients; pneumonia; risk; treatment cache: cord-306062-g9hk1iq5.txt plain text: cord-306062-g9hk1iq5.txt item: #1768 of 2876 id: cord-306090-i8sriw08 author: Tan, Zihui title: Protecting health care workers in the front line: Innovation in COVID-19 pandemic date: 2020-05-15 words: 1669 flesch: 48 summary: The protection of health care workers (HCWs) is vital in continuing patient care in health care systems that are currently challenged by the pandemic, but also important in ensuring they do not spread the virus. The protection of health care workers is vital in continuing patient care in health care systems that are currently challenged by the pandemic, but also important in ensuring they do not spread the virus. keywords: care; health; pandemic; patients; testing cache: cord-306090-i8sriw08.txt plain text: cord-306090-i8sriw08.txt item: #1769 of 2876 id: cord-306092-5bi2q3jj author: Choi, Hee Joung title: Relationship between the Clinical Characteristics and Intervention Scores of Infants with Apparent Life-threatening Events date: 2015-05-13 words: 3350 flesch: 41 summary: Many studies have investigated potential predictors of subsequent events in ALTE patients. Accordingly, we could have missed some portion of ALTE patients. keywords: alte; events; infants; intervention; life; patients; study cache: cord-306092-5bi2q3jj.txt plain text: cord-306092-5bi2q3jj.txt item: #1770 of 2876 id: cord-306108-ja0wyr5w author: B K, Anupama title: A Review of Acute Myocardial Injury in Coronavirus Disease 2019 date: 2020-06-03 words: 4760 flesch: 28 summary: In general, as the presence of CVD and myocardial injury in COVID-19 patients has been associated with more severe outcomes and increased mortality, triaging patients with COVID-19 according to the presence of underlying CVD and evidence of myocardial injury for prioritized treatment strategies may be reasonable [25] . Among various cardiac complications, acute cardiac injury with elevated cardiac biomarkers has been described in early studies from China on hospitalized patients with COVID-19. keywords: acute; cardiac; covid-19; disease; injury; myocarditis; patients; sars; troponin cache: cord-306108-ja0wyr5w.txt plain text: cord-306108-ja0wyr5w.txt item: #1771 of 2876 id: cord-306149-sd0s0jup author: Ratanarat, Ranistha title: Critical Care Management of Patients with COVID-19: Early Experience in Thailand date: 2020-05-18 words: 3098 flesch: 40 summary: The objective of this report is to outline our initial experience with the management of COVID-19 patients requiring intensive care unit (ICU) admission. Chest computed tomography (CT) findings in COVID-19 patients are more specific, showing bilateral, multi-lobar ground-glass opacification with the so-called crazy paving. keywords: care; cases; coronavirus; covid-19; disease; patients; thailand; therapy cache: cord-306149-sd0s0jup.txt plain text: cord-306149-sd0s0jup.txt item: #1772 of 2876 id: cord-306154-nm0g79ih author: JEGANATHAN, Sumithra title: Adherence and Acceptability of Telehealth Appointments for High Risk Obstetrical Patients During the COVID-19 Pandemic date: 2020-09-22 words: 1988 flesch: 44 summary: 262 A strength of this study includes the use of a digital appointment system to record patient visits, 265 which enabled an accurate assessment of the rates of attended and missed appointments between 266 the two time periods. Objective The study aims to: 1) Describe patient and provider attitudes toward telehealth for delivery of high risk obstetrical care in a large health care system with both urban and suburban settings. keywords: care; patient; telehealth; visits cache: cord-306154-nm0g79ih.txt plain text: cord-306154-nm0g79ih.txt item: #1773 of 2876 id: cord-306266-8qdrshz3 author: Scully, Crispian title: Respiratory medicine date: 2014-06-25 words: 13246 flesch: 40 summary: Respiratory infections must also be eradicated; sputum should first be sent for culture and sensitivity, but antimicrobials such as amoxicillin should be started without await ing results. Immunocompromised persons (e.g. those with human immunode ficiency virus/acquired immune deficiency syndrome [HIV/AIDS] and transplant recipients) and people with bronchiectasis or cystic fibrosis are also susceptible to respiratory infections by a range of opportun istic microbes. keywords: asthma; blood; cases; cause; chest; copd; cough; diagnosis; disease; drugs; dyspnoea; infection; influenza; lung; obstruction; oxygen; patients; people; pneumonia; pulmonary; result; risk; sputum; symptoms; syndrome; table; therapy; treatment; tuberculosis cache: cord-306266-8qdrshz3.txt plain text: cord-306266-8qdrshz3.txt item: #1774 of 2876 id: cord-306351-ka6asw3m author: Alsuliman, Tamim title: A review of potential treatments to date in COVID-19 patients according to the stage of the disease date: 2020-05-30 words: 6067 flesch: 42 summary: key: cord-306351-ka6asw3m authors: Alsuliman, Tamim; Alasadi, Lugien; Alkharat, Banan; Srour, Micha; Alrstom, Ali title: A review of potential treatments to date in COVID-19 patients according to the stage of the disease date: 2020-05-30 journal: Curr Res Transl Med DOI: 10.1016/j.retram.2020.05.004 sha: doc_id: 306351 cord_uid: ka6asw3m Abstract Introduction and motivation: Since the end of 2019, the COVID-19 pandemic has affected millions of people worldwide. Since human safety data for Remdesivir are available from several clinical trials that tested Remdesivir's efficacy against Ebola virus, several clinical trials are already being held in the United States and China to investigate its efficacy treating COVID-19 patients [7, 26, 32] . keywords: coronavirus; cov-2; covid-19; data; disease; hcq; patients; pneumonia; sars; stage; study; treatment; trials; use cache: cord-306351-ka6asw3m.txt plain text: cord-306351-ka6asw3m.txt item: #1775 of 2876 id: cord-306377-s9j21zsy author: Yan, Li title: A machine learning-based model for survival prediction in patients with severe COVID-19 infection date: 2020-03-01 words: 3469 flesch: 50 summary: We apply the following diagnostic criteria [4] : 1) Epidemiological history: Traveled or lived in Wuhan within 14 days before onset; Had contact with patients with fever and respiratory symptoms from Wuhan within 14 days before onset; Had contact with COVID-19 patients (positive for COVID-19 nucleic acid) within 14 days before onset; Or part of a familial cluster of onsets; 2) Clinical manifestations: Fever and/or respiratory symptoms; Normal or decreased total white blood cell count or decreased lymphocyte count during early stage of onset; Typical imaging features. After February 19th, 2020, there were 26 new cleared severe patients, which were thus picked for the test together with other 3 cleared severe patients from Ying Cheng People's Hospital for testing. keywords: covid-19; data; features; license; model; patients; preprint; set; xgboost cache: cord-306377-s9j21zsy.txt plain text: cord-306377-s9j21zsy.txt item: #1776 of 2876 id: cord-306595-ru725fbr author: Ammor, Othmane title: Hidroxicloroquina / cloroquina y azitromicina en pacientes con COVID-19: estudio prospectivo de parámetros eléctricos date: 2020-09-11 words: 863 flesch: 50 summary: A receiver operating characteristic (ROC) curve analysis was J o u r n a l P r e -p r o o f carried out to explore a QTc threshold at baseline for which there would be no risk of major QTc prolongation. In our study, the association of chloroquine/hydroxychloroquine and azithromycin induced significant QTc prolongation in 33 of 87 patients (38%), but a severe prolongation was noted in only 13 (15%) patients (QTc > 500 ms or delta QTc > 60ms). keywords: hydroxychloroquine; patients; qtc cache: cord-306595-ru725fbr.txt plain text: cord-306595-ru725fbr.txt item: #1777 of 2876 id: cord-306646-6c7n0xir author: Crimi, Claudia title: Resumption of Respiratory Outpatient Services in the COVID-19 era: experience from Southern Italy date: 2020-07-02 words: 1249 flesch: 41 summary: The Sars-CoV-2 infection is mainly transmitted by respiratory droplets 3 and close contact, and both respiratory clinicians and patients are at increased risk for transmission during the outpatient visit and the pulmonary function testing procedures. Patients scheduled for an outpatient visit may also suffer from common respiratory symptoms that can mimic or represent undiagnosed cases of COVID-19. keywords: covid-19; date; function; outpatient; patients cache: cord-306646-6c7n0xir.txt plain text: cord-306646-6c7n0xir.txt item: #1778 of 2876 id: cord-306670-c2jm0g88 author: Zhang, Yan title: Association of Diabetes Mellitus with Disease Severity and Prognosis in COVID-19: A Retrospective Cohort Study date: 2020-05-22 words: 3136 flesch: 38 summary: Other laboratory findings showed no significant differences between the two groups of patients with respect to serum levels of CRP, PCT, and LDH, but COVID-19 patients Next, we compared the severity, treatment, and short-term prognosis of the COVID-19 patients with and without diabetes in Table 3 . The laboratory findings on admission showed that leucocytes and neutrophils count and the proportion of increased leucocytes were higher in COVID-19 patients with diabetes than those without, which might be explained by the fact that patients with diabetes were more susceptible to pathogens after a viral infection due to lower immune function. keywords: china; clinical; covid-19; diabetes; disease; patients; prognosis; study cache: cord-306670-c2jm0g88.txt plain text: cord-306670-c2jm0g88.txt item: #1779 of 2876 id: cord-306790-82nltfk3 author: Sheikh, Abu Baker title: Inferior Wall Myocardial Infarction in Severe COVID-19 Infection: A Case Report date: 2020-09-28 words: 2025 flesch: 37 summary: There is an emerging need to streamline these presentations to improve the health care provided to COVID-19 patients by using a triage system to classify patients with severe symptoms and those at risk of complications. With the ever-increasing number of COVID-19 patients, it is imperative to explore the factors related to the disease to aid patient management until a definitive vaccine is ready, as the disease is not limited to the respiratory system alone. keywords: acute; covid-19; disease; infarction; patients; pneumonia cache: cord-306790-82nltfk3.txt plain text: cord-306790-82nltfk3.txt item: #1780 of 2876 id: cord-306896-khn8epxd author: D'Souza, Ayman title: Tracheostomy intervention in intubated COVID positive patients: A survey of current clinical practice among ENT surgeons date: 2020-06-05 words: 1540 flesch: 43 summary: We therefore conducted this international survey to assess tracheostomy intervention in intubated COVID-19 positive patients amongst ENT Surgeons. While this survey represents a snap-shot of current activity in a rapidly changing clinical environment, it does nonetheless suggest that there is a place for tracheostomy intervention in COVID-19 positive intubated patients, but that this intervention is performed later (on average day 14) than would be classically recommended (days 7-10). keywords: intervention; patients; survey; tracheostomy cache: cord-306896-khn8epxd.txt plain text: cord-306896-khn8epxd.txt item: #1781 of 2876 id: cord-306997-84pjfawk author: Melazzini, Federica title: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy date: 2020-11-08 words: 3667 flesch: 39 summary: Since 100% of VTE patients had a Padua score greater than 4, we suggest performing upper and lower limb venous ultrasound in COVID-19 patients with a score > 4, as well as routinely in ICU patients to identify and treat DVT as soon as possible. Supplementary Table 1 shows characteristics and differences between VTE patients admitted to intensive care unit (ICU) and VTE general ward patients. keywords: clinical; covid-19; hospital; non; patients; risk; study; vte cache: cord-306997-84pjfawk.txt plain text: cord-306997-84pjfawk.txt item: #1782 of 2876 id: cord-307100-w33e2078 author: Douedi, Steven title: Successful Maternal and Fetal Outcomes in COVID-19 Pregnant Women: An Institutional Approach date: 2020-07-27 words: 1413 flesch: 47 summary: COVID-19 infection management in pregnant patients has been poorly defined and explained in the literature. What we know COVID-19) and pregnancy: What obstetricians need to know Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia Successful maternal and fetal outcomes in COVID-19 pregnant women… © None. keywords: covid-19; day; patient cache: cord-307100-w33e2078.txt plain text: cord-307100-w33e2078.txt item: #1783 of 2876 id: cord-307160-1vz0gw1w author: Morais-Almeida, Mário title: COVID-19, asthma, and biologic therapies: What we need to know date: 2020-05-16 words: 3565 flesch: 31 summary: Based on the information available, we are providing the current knowledge regarding the management of severe asthma patients with biologics during the COVID-19 pandemic. Biologic therapies should be used in severe asthma patients who qualify for them, in order to limit the need for OCS as much as possible (37). keywords: asthma; biologics; cov-2; covid-19; data; pandemic; patients; safety; sars cache: cord-307160-1vz0gw1w.txt plain text: cord-307160-1vz0gw1w.txt item: #1784 of 2876 id: cord-307217-0agij3z3 author: Sun, Qiulian title: Evolution of computed tomography manifestations of eleven patients with severe coronavirus disease 2019 (COVID‐19) pneumonia date: 2020-08-08 words: 979 flesch: 49 summary: CONCLUSIONS: Most of patients with severe COVID‐19 pneumonia showed marked improvement of acute exudative lesions on chest imagings, and satisfactory prognosis of severe COVID‐19 pneumonia could be achieved after active treatment. All rights reserved Eleven patients admitted to Taizhou Hospital of Wenzhou Medical University from January 24 to February 10, 2020 were diagnosed with severe COVID-19 pneumonia. keywords: covid-19; patients; pneumonia cache: cord-307217-0agij3z3.txt plain text: cord-307217-0agij3z3.txt item: #1785 of 2876 id: cord-307258-66lwpblq author: Li, Weixia title: Anesthesia Management and Perioperative Infection Control in Patients With the Novel Coronavirus date: 2020-03-29 words: 3114 flesch: 38 summary: All anesthesia machines used in infected patients or those with unknown status should be treated using disinfection standards established for communicable fungi, viruses, and vegetative bacteria. The latter leads to an acceptable choice of materials and techniques for personal protection and prevention of cross-contamination to other patients and staff. keywords: anesthesia; care; coronavirus; covid-19; infection; novel; patients; pneumonia cache: cord-307258-66lwpblq.txt plain text: cord-307258-66lwpblq.txt item: #1786 of 2876 id: cord-307285-bxy0zsc7 author: Dar Odeh, Najla title: COVID-19: Present and Future Challenges for Dental Practice date: 2020-04-30 words: 4713 flesch: 40 summary: Following the recommended cross-infection control procedures, spreading awareness based on evidence and not misconceptions, identifying emergency cases indicated for dental treatment, and practicing effective tele-dentistry when needed can all be helpful for dental patients and community as a whole. Realizing the severity of outcomes associated with this disease and its high rate of transmission, dentists were instructed by regulatory authorities, such as the American Dental Association, to stop providing treatment to dental patients except those who have emergency complaints. keywords: cases; covid-19; dental; dentists; drug; healthcare; infection; patients; treatment; virus cache: cord-307285-bxy0zsc7.txt plain text: cord-307285-bxy0zsc7.txt item: #1787 of 2876 id: cord-307287-zpq6byml author: Poulsen, Nadia Nicholine title: Cyclosporine and COVID‐19: Risk or Favorable? date: 2020-08-10 words: 4462 flesch: 26 summary: Two drugs have shown promising effect on COVID-19 patients, Remdesivir proved in a recent trial to reduce time to recovery, but had no effect on mortality 1 . The first group had a mortality of 50% and the second group only 12.5% thus supporting the idea that continuous use of cyclosporine might be beneficial in COVID-19 patients. keywords: coronavirus; covid-19; cyclosporine; disease; patients; recipients; replication; respiratory; sars; syndrome; transplant cache: cord-307287-zpq6byml.txt plain text: cord-307287-zpq6byml.txt item: #1788 of 2876 id: cord-307309-s0t4kp2x author: Liang, Ying title: Symptoms, Management and Healthcare Utilization of COPD Patients During the COVID-19 Epidemic in Beijing date: 2020-10-14 words: 3016 flesch: 41 summary: A recent report from American Thoracic Society Patient Education emphasized that an action plan for COPD patients is important and helps patients to manage the lung condition and monitor the symptoms. Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the global burden of disease study 2017 Chronic obstructive pulmonary disease in China: a nationwide prevalence study Determinants of smoking cessation in patients with COPD treated in the outpatient setting Smoking cessation in chronic obstructive pulmonary disease patients aged 40 years or older in China Seasonal and regional variations in chronic obstructive pulmonary disease exacerbation rates in adults without cardiovascular risk factors All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. keywords: copd; covid-19; disease; epidemic; patients; symptoms cache: cord-307309-s0t4kp2x.txt plain text: cord-307309-s0t4kp2x.txt item: #1789 of 2876 id: cord-307653-nyr6mtj1 author: Palmeira, Patricia title: Why is SARS-CoV-2 infection milder among children? date: 2020-05-11 words: 3461 flesch: 22 summary: The Facts During the Third Epidemic COVID-19 in posttransplant patients-report of 2 cases Clinical course of COVID-19 in a series of patients with chronic arthritis treated with immunosuppressive targeted therapies Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease A pneumonia outbreak associated with a new coronavirus of probable bat origin Adaptive immune responses to primary and secondary dengue virus infections Antibodydependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS Clinical features of patients infected with 2019 novel coronavirus in Wuhan Pathological findings of COVID-19 associated with acute respiratory distress syndrome Hemophagocytic lymphohistiocytosis: a rare diagnosis, an even rarer opportunity to appraise our understanding of the immune system Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis Macrophage activation syndrome: A severe and frequent manifestation of acute pancreatitis in 362 childhood-onset compared to 1830 adult-onset systemic lupus erythematosus patients Development and initial validation of the MS score for diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis Refined characterization and reference values of the pediatric T-and B-cell compartments Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study Non-specific effects of BCG vaccine on viral infections CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses BCG Vaccination Enhances the Immunogenicity of Subsequent Influenza Vaccination in Healthy Volunteers: A Randomized, Placebo-Controlled Pilot Study Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of COVID-19 and Kawasaki Disease: Novel Virus and Novel Case Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study This is relevant because other clinical studies indicate that COVID-19 patients have lymphocytopenia with high levels of several cytokines and chemokines, such as G-CSF, IP-10, MCP-1, MIP-1a, and TNF-a (48, 49) . keywords: ace2; angiotensin; children; cov-2; covid-19; disease; infection; patients; sars cache: cord-307653-nyr6mtj1.txt plain text: cord-307653-nyr6mtj1.txt item: #1790 of 2876 id: cord-307660-onz6vfre author: Titanji, Boghuma K title: Use of Baricitinib in Patients with Moderate and Severe COVID-19 date: 2020-06-29 words: 1088 flesch: 36 summary: Coronavirus Disease 2019 -Situation report number 148 COVID-19: consider cytokine storm syndromes and immunosuppression Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Baricitinib as potential treatment for 2019-nCoV acute respiratory disease COVID-19: combining antiviral and anti-inflammatory treatments Baricitinib therapy in COVID-19: A pilot study on safety and clinical impact Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID-19 patients IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes Estimates of the severity of coronavirus disease 2019: a model-based analysis Baricitinib for the treatment of rheumatoid arthritis and systemic lupus erythematosus: a 2019 update THU0211 Meta-analysis of serious infections with baricitinib, tofacitinib and biologic dmards in rheumatoid arthritis In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vincent Marconi and Raymond F Schinazi are partially funded by -Emory University Center for AIDS Research (AI050409). Severe COVID-19 patients met any of the following criteria; respiratory rate (RR) >30 times/min, oxygen saturation by pulse oximetry 93% at rest or PaO2/FiO2<300 mmHg. keywords: baricitinib; covid-19; disease; patients cache: cord-307660-onz6vfre.txt plain text: cord-307660-onz6vfre.txt item: #1791 of 2876 id: cord-307690-1qqyixun author: Preti, Emanuele title: Personality Disorders in Time of Pandemic date: 2020-11-10 words: 5276 flesch: 28 summary: Trends Psychiatry Psychother Psychological and behavioural responses to coronavirus disease 2019: the role of personality Cognitive therapy of personality disorders Specific types of personality disorders Cognitive and brain function in schizotypal personality disorder Schizotypal personality disorder: a current review Neurophysiological evidence of impaired self-monitoring in schizotypal personality disorder and its reversal by dopaminergic antagonism The Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE): further description and extended norms Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring Personality disorders in homeless drop-in center clients Study of the influence of mental disorders on the problems of social rehabilitation Schizoid personality traits among the homeless mentally III: a quantitative and qualitative report Personality disorders and treatment drop out in the homeless Borderline personality disorder: hypothalamus pituitary adrenal axis and findings from neuroimaging studies Neural correlates of emotional action control in anger-prone women with borderline personality disorder Relationship between personality dimensions and psychological well-being among university students during pandemic lockdown Comparison of attachment styles in borderline personality disorder and obsessive-compulsive personality disorder Cluster B personality traits and attachment Reviewing the clinical significance of 'fear of abandonment' in borderline personality disorder Trust and rejection sensitivity in personality disorders Postdisaster course of alcohol use disorders in systematically studied survivors of 10 disasters Tobacco use after experiencing a major natural disaster: analysis of a longitudinal study of 2063 young adults Consumption of cigarettes, alcohol, and marijuana among New York City residents six months after the September 11 terrorist attacks Suicidal thoughts and behaviors and social isolation: a narrative review of the literature Heightened sensitivity to facial expressions of emotion in borderline personality disorder Affective temperament, attachment style, and the psychological impact of the COVID-19 outbreak: an early report on the Italian general population Temperament traits and personality disorders. Predictors for personality disorders Depression in histrionic personality disorder Exploring the structure of narcissism: toward an integrated solution The narcissism spectrum model: a synthetic view of narcissistic personality Initial construction and validation of the Pathological Narcissism Inventory Narcissistic subtypes and contingent self-esteem: do all narcissists base their self-esteem on the same domains? Grandiose and entitled, but still fragile: a network analysis of pathological narcissistic traits Abdelrahman M Personality traits, risk perception, and protective behaviors of Arab residents of Qatar during the COVID-19 pandemic Pathological narcissism and narcissistic personality disorder Factorial structure of traits delineating personality disorders in clinical and general population samples Coronavirus (COVID-19) in the United Kingdom: a personality-based perspective on concerns and intention to self-isolate Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and metaanalysis with comparison to the COVID-19 pandemic Obsessive-compulsive personality disorder and component personality traits Intolerance of uncertainty and obsessivecompulsive personality disorder Relationship between hypochondriasis and obsessivecompulsive personality disorder: close relatives separated by nosological schemes? keywords: cluster; covid-19; disorders; measures; mitigation; pandemic; patients; pds; personality; traits cache: cord-307690-1qqyixun.txt plain text: cord-307690-1qqyixun.txt item: #1792 of 2876 id: cord-307710-dlpfbnb1 author: Neradi, Deepak title: Management of Orthopaedic Patients During COVID-19 Pandemic in India: A Guide date: 2020-04-27 words: 1582 flesch: 53 summary: These patients should be managed as COVID positive patients and strict precautions should be taken to avoid transmission to caregivers or to other patients. Ensure that the healthcare staff including the doctor, nurses and paramedical staff have no signs and symptoms related to COVID-19 infection or any contact with COVID patients in the past 14 days and it is better to screen the health care staff, if feasible. keywords: care; covid-19; health; india; patients cache: cord-307710-dlpfbnb1.txt plain text: cord-307710-dlpfbnb1.txt item: #1793 of 2876 id: cord-307758-a4sgt66g author: Hong, Ching-Ye title: Acute respiratory symptoms in adults in general practice date: 2004-06-17 words: 3928 flesch: 52 summary: key: cord-307758-a4sgt66g authors: Hong, Ching-Ye; Lin, Raymond TP; Tan, Elaine SL; Chong, Phui-Nah; Tan, Yvette SL; Lew, Yii-Jen; Loo, Liat-Hui title: Acute respiratory symptoms in adults in general practice date: 2004-06-17 journal: The purpose of this study was to determine the infective aetiology in patients who presented to primary care doctors with acute respiratory symptoms. keywords: culture; group; infections; pathogens; patients; pcr; study; symptoms; virus cache: cord-307758-a4sgt66g.txt plain text: cord-307758-a4sgt66g.txt item: #1794 of 2876 id: cord-307808-0t6sw0zp author: Romanick-Schmiedl, Sue title: Telemedicine — maintaining quality during times of transition date: 2020-06-01 words: 1595 flesch: 33 summary: In general, history taking for such patients is more comprehensive than for focused follow-up visits. Although telehealth offers solutions for basic access to health care in the midst of the current pandemic, it is not yet uniformly integrated into regular health-care systems and, as a 'disruptive process' , it necessitates major adaptations to existing frameworks 4 . keywords: care; health; patient; person; telemedicine cache: cord-307808-0t6sw0zp.txt plain text: cord-307808-0t6sw0zp.txt item: #1795 of 2876 id: cord-307862-a082sghm author: ten Cate, Hugo title: Thrombosis management in times of COVID-19 epidemy; a Dutch perspective date: 2020-04-20 words: 1231 flesch: 34 summary: While normally, a Wells rule or similar algorithm will be applied to work up such patients (and ECG recording of course) with a d-dimer test in case of a low suspicion for PE, the threat is that in the present situation this part of the diagnostic pathway is forgotten. [1] has caused major shifts in healthcare organization, towards far more and acute attention for patients suspected from COVID-19 infection at the potential cost of less attention for regular care. keywords: covid-19; infection; patients cache: cord-307862-a082sghm.txt plain text: cord-307862-a082sghm.txt item: #1796 of 2876 id: cord-308002-abgv87e4 author: Porta, Camillo title: Editorial debate: Challenges an oncologist has to face during the SARS-CoV-2 pandemic within a universal healthcare system date: 2020-05-04 words: 737 flesch: 46 summary: org/ licenses/ by-nc/ 4. 0/. Covid-19 and Italy: what next? Ethical prioritization of patients during disaster triage: a systematic review of current evidence Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13 Editorial debate: challenges we oncologists, working within a universal healthcare system, have to face in these hard times Mortality within 30 days of chemotherapy: a clinical governance benchmarking issue for oncology patients Why do our patients get chemotherapy until the end of life? Now, in order to protect our patients from the unnecessary harm that may result from being admitted to hospital during a pandemic, as well as to preserve valuable resources for the management of Covid-19 patients, we should start revising this attitude. keywords: healthcare; patients cache: cord-308002-abgv87e4.txt plain text: cord-308002-abgv87e4.txt item: #1797 of 2876 id: cord-308010-ix0xi5jb author: Mcloughlin, Benjamin C. title: Functional and cognitive outcomes after COVID-19 delirium date: 2020-07-14 words: 2273 flesch: 41 summary: To ascertain delirium prevalence and outcomes in COVID-19. Nonetheless, our data are strengthened by the consistent and systematic approach to delirium detection and robust methods for follow-up. keywords: covid-19; delirium; mortality; outcomes; patients cache: cord-308010-ix0xi5jb.txt plain text: cord-308010-ix0xi5jb.txt item: #1798 of 2876 id: cord-308071-1bk3xuwf author: Lang, Christian title: Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient date: 2020-08-25 words: 2438 flesch: 38 summary: 11, 12 The case we present here extends the reports from China by showing that lung transplantation can be done in patients with positive RT-PCR results, provided that Vero cell cultures confirm non-infectivity. 15 As donor organs are a scarce resource, it is important to consider lung transplantation only for patients with irreversibly damaged lungs. keywords: covid-19; day; lung; patient; pcr; sars; transplantation cache: cord-308071-1bk3xuwf.txt plain text: cord-308071-1bk3xuwf.txt item: #1799 of 2876 id: cord-308075-1ftswsm8 author: Segura, Patricia Sanz title: Involvement of the digestive system in COVID-19. A review date: 2020-10-09 words: 4834 flesch: 36 summary: Epub ahead of print Air surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection First case of 2019 novel coronavirus in the United States Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: A descriptive, cross-sectional multicenter study Prevalence and characteristics of gastrointestinal symptoms in patients with SARS-CoV-2 infection in the United States: A multicenter cohort study. In the latest update, of 12 May 2020, the controlled cohort was 491 patients; up to that date, notably, there was a 36% mortality rate in patients with cirrhosis ----much higher than the mortality rate in other patients with non-cirrhosis chronic liver disease (7%) and that in patients with a liver transplant (20%). keywords: cases; covid-19; disease; endoscopy; infection; liver; patients; risk; sars; studies; symptoms cache: cord-308075-1ftswsm8.txt plain text: cord-308075-1ftswsm8.txt item: #1800 of 2876 id: cord-308112-w96ncfla author: Gautret, Philippe title: Nullane salus extra ecclesiam date: 2020-08-01 words: 739 flesch: 34 summary: By bringing together the sparse published data on the subject, it may become possible to carefully compare, a selection of outcomes in patients treated with chloroquine derivatives with matched patients receiving another treatment or standard care. Our group conducted such an analysis using aggregated data from published studies matched with our own observational data showing that patients treated with a combination of hydroxychloroquine and azithromycin (HCQ-AZ) were three times less likely to die than matched patients treated either with lopinavir-ritonavir or standard care. keywords: data; patients cache: cord-308112-w96ncfla.txt plain text: cord-308112-w96ncfla.txt item: #1801 of 2876 id: cord-308169-a0ft6wdy author: Custovic, A. title: EAACI position statement on asthma exacerbations and severe asthma date: 2013-11-06 words: 7718 flesch: 30 summary: Recent joint modelling of longitudinal observations on wheezing from parental reports and medical records identified a novel phenotype of persistent troublesome wheeze with high rates of severe asthma exacerbations and healthcare utilization (24) . A decline in lung function has also been associated with severe asthma exacerbations in adult asthma (4) . keywords: airway; asthma; care; childhood; children; clinical; control; disease; exacerbations; lung; need; patients; risk; studies; study; treatment cache: cord-308169-a0ft6wdy.txt plain text: cord-308169-a0ft6wdy.txt item: #1802 of 2876 id: cord-308184-w8ewm8ve author: Sarzi-Puttini, Piercarlo title: How to handle patients with autoimmune rheumatic and inflammatory bowel diseases in the COVID-19 era: An expert opinion date: 2020-05-05 words: 3437 flesch: 32 summary: Although the available data do not suggest that there is a specific risk of SARS-CoV-2 infection and morbidity in IBD patients receiving immunosuppressive treatment, it is known that opportunistic infections have deleterious effects on such patients, which suggests that the risks and benefits of the treatment should be balanced before continuing its administration. However, to the best of our knowledge, the only data concerning the risk of SARS-CoV-2 infection in IBD patients come from just one study [19] , and there are no data concerning the risk in rheumatic patients. keywords: covid-19; diseases; drugs; ibd; infection; patients; risk; treatment cache: cord-308184-w8ewm8ve.txt plain text: cord-308184-w8ewm8ve.txt item: #1803 of 2876 id: cord-308195-nlibv0u4 author: Arleo, T. L. title: Clinical Course and Outcomes of coronavirus disease 2019 (COVID-19) in Rheumatic Disease Patients on Immunosuppression: A case Cohort Study at a Single Center with a Significantly Diverse Population date: 2020-10-27 words: 3588 flesch: 40 summary: In hospitalized rheumatic disease patients, one potential confounder is that rheumatic disease patients admitted to the hospital experience poor outcomes regardless of COVID-19 infection key: cord-308195-nlibv0u4 authors: Arleo, T. L.; Tong, D. C.; Shabto, J. M.; O'Keefe, G. D.; Khosroshahi, A. title: Clinical Course and Outcomes of coronavirus disease 2019 (COVID-19) in Rheumatic Disease Patients on Immunosuppression: A case Cohort Study at a Single Center with a Significantly Diverse Population date: 2020-10-27 journal: nan DOI: 10.1101/2020.10.26.20219154 sha: doc_id: 308195 cord_uid: nlibv0u4 Objectives To determine clinical course and outcomes in rheumatic disease patients with coronavirus disease 2019 (COVID-19) and compare results to uninfected patients. keywords: covid-19; disease; license; medrxiv; patients; preprint cache: cord-308195-nlibv0u4.txt plain text: cord-308195-nlibv0u4.txt item: #1804 of 2876 id: cord-308212-l8flyso7 author: Kong, Ha Eun title: Applying the ethical principles of resource allocation to drugs in limited supply during a public health crisis date: 2020-04-21 words: 566 flesch: 38 summary: While the benefit of antimalarials to COVID-19 patients remains 61 uncertain, high-quality evidence supports continuing treatment in patients with severe SLE. Random selection can be used for selecting among patients with comparable prognoses. keywords: covid-19; patients cache: cord-308212-l8flyso7.txt plain text: cord-308212-l8flyso7.txt item: #1805 of 2876 id: cord-308252-qwoo7b1l author: Cardinale, Vincenzo title: Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis date: 2020-09-16 words: 4606 flesch: 30 summary: As previously demonstrated in SARS-CoV-1, gastrointestinal manifestations are significant extrapulmonary complaints in Covid-19 patients [8] [9] [10] [11] . Covid-19 patients are at a high risk of both venous and arterial thromboembolism keywords: coronavirus; cov-2; covid-19; damage; disease; gut; infection; liver; patients; response; sars; syndrome cache: cord-308252-qwoo7b1l.txt plain text: cord-308252-qwoo7b1l.txt item: #1806 of 2876 id: cord-308313-3speddao author: Jaspard, Marie title: Linezolid-Associated Neurologic Adverse Events in Patients with Multidrug-Resistant Tuberculosis, France date: 2020-08-17 words: 4292 flesch: 38 summary: We therefore evaluated the occurrence and management of neurologic and ophthalmologic adverse effects among MDR TB patients receiving a linezolid-based treatment regimen. However, in a study of MDR TB patients in India, the high rate of neuropathy was explained by a higher proportion of malnourished patients (27) . keywords: effects; linezolid; months; neuropathy; patients; treatment; tuberculosis cache: cord-308313-3speddao.txt plain text: cord-308313-3speddao.txt item: #1807 of 2876 id: cord-308390-ei96iuw3 author: Wu, Junping title: Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy date: 2020-11-04 words: 551 flesch: 38 summary: This case series suggests that ozonated autohemotherapy may be an alternative noninvasive medical treatment for COVID-19 patients. These findings 53 indicate that ozonated autohemotherapy may be a new strategy to treat patients infected 54 with betacoronaviruses. keywords: autohemotherapy; patients cache: cord-308390-ei96iuw3.txt plain text: cord-308390-ei96iuw3.txt item: #1808 of 2876 id: cord-308445-3j2q83ll author: Rhim, Jung-Woo title: Pandemic 2009 H1N1 virus infection in children and adults: A cohort study at a single hospital throughout the epidemic date: 2012-03-26 words: 4933 flesch: 45 summary: The influence of vaccination on the clinical features of hemorrhagic fever with renal syndrome in the last 5 years The changing epidemiology of HIVinfected patients in the intensive care unit Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza Canadian Critical Care Trials Group H1N1 Collaborative: Critically ill patients with 2009 influenza A (H1N1) infection in Canada A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan the HUS Investigation Team: Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany -preliminary report Fatal cases of 2009 pandemic influenza A (H1N1) in Korea World Health Organization: WHO guidelines for pharmacological management of pandemic influenza A (H1N1) 2009 and other influenza viruses. Because there have been no controlled-clinical trials that use corticosteroids to treat influenza patients since the last pandemic (1968 Hong Kong flu), the efficacy of corticosteroids on influenza infection is not known [36] . keywords: age; group; h1n1; influenza; pandemic; patients; pneumonia; virus cache: cord-308445-3j2q83ll.txt plain text: cord-308445-3j2q83ll.txt item: #1809 of 2876 id: cord-308466-f0iu6sje author: Ko, Fanny W. title: Acute exacerbation of COPD date: 2016-03-30 words: 8629 flesch: 27 summary: 9 Impairment of working ability or early retirement in COPD patients due to physical disability contributes to a substantial socioeconomic loss and health expenditure. A recent Cochrane review found no difference in outcomes for nebulizers and MDI with spacers in patients with acute asthma; 55 a similar appraisal of the evidence specific to COPD patients is awaited. keywords: aecopd; antibiotics; chronic; copd; disease; exacerbations; hospital; management; mortality; patients; respiratory; risk; studies; study; treatment; use cache: cord-308466-f0iu6sje.txt plain text: cord-308466-f0iu6sje.txt item: #1810 of 2876 id: cord-308491-fc46k594 author: Mossa-Basha, Mahmud title: Policies and Guidelines for COVID-19 Preparedness: Experiences from the University of Washington date: 2020-04-08 words: 3312 flesch: 45 summary: We have created scanner throughput plans, including designated CT scanners and imaging suites for COVID-19 positive patients. At our hospitals, imaging rooms are 8 closed for 1 hour for airborne precautions in rooms with a minimum of 6 air exchanges per hour. keywords: air; care; covid-19; hospital; imaging; patient; radiology; room cache: cord-308491-fc46k594.txt plain text: cord-308491-fc46k594.txt item: #1811 of 2876 id: cord-308803-i934doud author: PONNAPA REDDY, M. title: Prone positioning of non-intubated patients with COVID-19 - A Systematic Review and Meta-analysis date: 2020-10-14 words: 4160 flesch: 41 summary: Necessity Is the Mother of Invention Prone position for acute respiratory failure in adults Prone positioning improves oxygenation in spontaneously breathing nonintubated patients with hypoxemic acute respiratory failure: A retrospective study Prone positioning in non-intubated patients with COVID-19: raising the bar Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients Alternatives to Invasive Ventilation in the COVID-19 Pandemic Relationship between gas exchange response to prone position and lung recruitability during acute respiratory failure Prone position improves mechanics and alveolar ventilation in acute respiratory distress syndrome COVID-19 Does Not Lead to a Typical Preferred reporting items for systematic reviews and metaanalyses: the PRISMA statement COAP Living Evidence on COVID-19 Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barre syndrome: From systematic review to living systematic review Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses Ottawa2013 Methodological quality of case series studies Correlation between the levels of SpO2and PaO2 Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range Metaprop: a Stata command to perform meta-analysis of binomial data Measuring inconsistency in meta-analyses Bias in meta-analysis detected by a simple, graphical test Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study Prone Positioning of Non-Intubated Patients with COVID-19 Reduced ICU demand with early CPAP and proning in COVID-19 at Bradford: a single centre cohort Early awake prone position combined with high-flow nasal oxygen therapy in severe COVID-19: a case series Prone positioning in high-flow nasal cannula for COVID-19 patients with severe hypoxemia: a pilot study Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit Prone and Lateral Positioning in Spontaneously Breathing Patients With COVID-19 key: cord-308803-i934doud authors: PONNAPA REDDY, M.; SUBRAMANIAM, A.; LIM, Z. J.; ZUBAREV, A.; AFROZ, A.; BILLAH, B.; TIRUVOIPATI, R.; RAMANATHAN, K.; WONG, S. N.; BRODIE, D.; FAN, E.; SHEKAR, K. title: Prone positioning of non-intubated patients with COVID-19 - A Systematic Review and Meta-analysis date: 2020-10-14 journal: nan DOI: 10.1101/2020.10.12.20211748 sha: doc_id: 308803 cord_uid: i934doud Purpose: Several studies have reported adopting prone positioning (PP) in non-intubated patients with COVID-19-related hypoxaemic respiratory failure. keywords: covid-19; license; oxygenation; patients; preprint; review; studies cache: cord-308803-i934doud.txt plain text: cord-308803-i934doud.txt item: #1812 of 2876 id: cord-308906-et7duogt author: Di, Gaohong title: Simple and Effective Primary Assessment of Emergency Patients in a COVID-19 Outbreak Area: A Retrospective, Observational Study date: 2020-08-20 words: 3675 flesch: 43 summary: This result indicated that the preoperative classification system used with emergency patients based on body temperature measurements and chest CT scans was effective for patients who presented mild symptoms or were the incubation period. 2, 5 However, most emergency patients present with fever and leukocytosis, which made it more challenging to screen and identify atypical patients, DovePress asymptomatic patients, and patients who were still in the incubation period for COVID-19 infection. keywords: covid-19; crp; emergency; infection; patients; study; surgery; time cache: cord-308906-et7duogt.txt plain text: cord-308906-et7duogt.txt item: #1813 of 2876 id: cord-308907-elz62jlg author: Joob, Beuy title: 2019 Novel coronavirus and awareness date: 2020-05-04 words: 271 flesch: 62 summary: Multistep of disease transmission from China mainland to second Hence, we have to be aware of the possibility of disease in any patients with suspicious clinical feature regardless of the history of travel or contact to possible infected cases. keywords: disease cache: cord-308907-elz62jlg.txt plain text: cord-308907-elz62jlg.txt item: #1814 of 2876 id: cord-308968-m4pzsfkd author: Mercadante, Amanda R. title: Choosing Evolution over Extinction: Integrating Direct Patient Care Services and Value-Based Payment Models into the Community-Based Pharmacy Setting date: 2020-07-24 words: 6376 flesch: 44 summary: The following search terms were utilized: health care payment model, pharmacy model, value-based payment, fee for service, community pharmacy role, pharmacist services, community pharmacy services. Four collaborative payment models have been proposed, offering methods to quell the monetary problems that exist and are predicted to continue with the closure of community pharmacies and sustained influence of PBMs. keywords: care; community; health; healthcare; model; patients; payment; pbms; pharmacies; pharmacy; plans; services cache: cord-308968-m4pzsfkd.txt plain text: cord-308968-m4pzsfkd.txt item: #1815 of 2876 id: cord-308979-qhlvd2mt author: Sumino, Kaharu C. title: Detection of Severe Human Metapneumovirus Infection by Real-Time Polymerase Chain Reaction and Histopathological Assessment date: 2005-09-15 words: 4301 flesch: 35 summary: Moreover, the prevalence and other characteristics of hMPV infection in the clinical setting of patients undergoing bronchoscopy for respiratory tract infections still need to be defined. In the present study, we add several critical pieces to the diagnostic and clinical matrix for hMPV infection: (1) we detected hMPV at a frequency similar to that of other respiratory tract viruses in patients who underwent bronchoscopy for suspected respiratory tract infection; (2) we quantitatively detected hMPV by real-time PCR in bronchoscopy samples from patients with severe respiratory tract illness but not in those without symptoms or signs of respiratory tract infection; (3) we used a viral culture system to develop a specific antisense probe for hMPV and then demonstrated hMPV mRNA in the lung tissue samples; and (4) we found organizing and acute lung injury and the prominent formation of smudge cells in the lung tissue samples of these patients, thereby suggesting that this pattern may be characteristic of hMPV infection. keywords: cells; hmpv; illness; infection; lung; patients; samples; tract; virus cache: cord-308979-qhlvd2mt.txt plain text: cord-308979-qhlvd2mt.txt item: #1816 of 2876 id: cord-309001-erm705tg author: Liu, Q. title: Laboratory findings and a combined multifactorial approach to predict death in critically ill patients with COVID-19: a retrospective study date: 2020-06-30 words: 3457 flesch: 48 summary: (1) Combination of predictors and development of predictive model Three laboratory indicators were combined to provide a predictive probability value for the outcome of death in COVID-19 patients, which was expressed in terms of PRE. The cohort study from Jin Yin-tan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) also found that DD greater than 1 μg/ml was the risk factor of death in COVID-19 patients. keywords: clinical; coronavirus; covid-19; death; disease; patients; study cache: cord-309001-erm705tg.txt plain text: cord-309001-erm705tg.txt item: #1817 of 2876 id: cord-309024-pu830bn9 author: Bernardo, Luca title: Severe prolonged neutropenia following administration of tocilizumab in a patient affected by COVID-19: a case report and brief review of the literature date: 2020-09-14 words: 2963 flesch: 35 summary: Higher serum procalcitonin and IL-6 levels predict worse diagnosis for acute respiratory distress syndrome patients with multiple organ dysfunction Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China COVID-19: consider cytokine storm syndromes and immunosuppression Effective treatment of severe COVID-19 patients with tocilizumab A review of recent advances using tocilizumab in the treatment of rheumatic diseases Tocilizumab (Actemra) Efficacy and safety of tocilizumab in Korean patients with active rheumatoid arthritis Adverse effects of biologics: a network meta-analysis and Cochrane overview Longterm safety and efficacy of tocilizumab in patients with rheumatoid arthritis: a cumulative analysis of up to 4.6 years of exposure Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials Tocilizumab-induced neutropenia in rheumatoid arthritis patients with previous history of neutropenia: case series and review of literature How to approach neutropenia Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials Effects of tocilizumab on neutrophil function and kinetics Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia? Chinese Clinical Trial Registry. • Black patients are more likely to have lower neutrophil counts than patients of other ethnicities due to a genetic predisposition. keywords: coronavirus; covid-19; infections; neutropenia; patients; tocilizumab cache: cord-309024-pu830bn9.txt plain text: cord-309024-pu830bn9.txt item: #1818 of 2876 id: cord-309026-l2rh9bie author: Sweiss, Nadera J. title: When the game changes: Guidance to adjust sarcoidosis management during the COVID-19 pandemic date: 2020-04-29 words: 1539 flesch: 35 summary: Sarcoidosis patients may have an increased risk of a poor outcome and death from COVID-19 infection for several reasons. In sarcoidosis patients with organ or life-threatening disease, a significant dose reduction or discontinuation of therapy may be contraindicated because of the risk of severe unfavorable outcomes. keywords: covid-19; disease; patients; sarcoidosis cache: cord-309026-l2rh9bie.txt plain text: cord-309026-l2rh9bie.txt item: #1819 of 2876 id: cord-309194-jtouafgd author: Lu, Xiao title: Lung ultrasound score in establishing the timing of intubation in COVID-19 interstitial pneumonia: A preliminary retrospective observational study date: 2020-09-03 words: 3673 flesch: 40 summary: Our study examined COVID-19 patients with interstitial pneumonia, using the clinical application of LUS to assess intubation timing. From February 14, 2020 to March 6, 2020, COVID-19 patients were admitted in the ICU of the Cancer Center of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. keywords: covid-19; intubation; lung; lus; patients; study; ultrasound cache: cord-309194-jtouafgd.txt plain text: cord-309194-jtouafgd.txt item: #1820 of 2876 id: cord-309207-n8u8ddv7 author: Lechien, Jerome R. title: Loss of Smell and Taste in 2013 European Patients With Mild to Moderate COVID-19 date: 2020-05-26 words: 904 flesch: 47 summary: At the time of evaluation, 573 of 1754 patients regained their sense of smell, 60.9% of them between 5 and 14 days after the onset of smell loss; mean duration of olfactory dysfunction was 8.4 days (SD, 5.1). Using a standardized online questionnaire, we collected clinical and epidemiologic data from hospitalized patients on discharge day and from ambulatory patients after the resolution of key symptoms (such as cough, fever, dyspnea, headache, myalgia, and arthralgia) (Figure) . keywords: loss; patients; smell cache: cord-309207-n8u8ddv7.txt plain text: cord-309207-n8u8ddv7.txt item: #1821 of 2876 id: cord-309214-v2iqgjc4 author: Nougier, Christophe title: Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis date: 2020-07-15 words: 2632 flesch: 35 summary: Interestingly, ICU patients with thrombotic complications had a more thrombogenic TEM-tPA profile compared to Covid-19 patients without thrombosis ( Figure 1B) . The discrepancy between the frequency of thrombotic complications and the intensity of antithrombotic prophylaxis administered to Covid-19 patients is intriguing. keywords: covid-19; generation; icu; levels; patients; thrombin; thrombosis; tpa cache: cord-309214-v2iqgjc4.txt plain text: cord-309214-v2iqgjc4.txt item: #1822 of 2876 id: cord-309236-p4c2d5y3 author: Khurram, Ruhaid title: Spontaneous tension pneumothorax and acute pulmonary emboli in a patient with COVID-19 infection date: 2020-08-11 words: 2414 flesch: 35 summary: World health organisation coronavirus disease (COVID-19) Dashboard Tension pneumothorax in a patient with COVID-19 Spontaneous pneumothorax and subcutaneous emphysema in COVID-19 patient: case report Spontaneous pneumomediastinum in COVID-19 COVID-19 with spontaneous pneumomediastinum SARS-CoV-2 pulmonary infection revealed by subcutaneous emphysema and pneumomediastinum COVID-19 with cystic features on computed tomography: a case report Acute pulmonary embolism in COVID-19 related hypercoagulability Severe pulmonary embolism in COVID-19 patients: a call for increased awareness Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Diagnostic performance of CT and reverse transcriptasepolymerase chain reaction for coronavirus disease 2019: Routine blood test results on admission were as follows: haemoglobin: 129 g/L; white cell count: 11.2×10 9 /L; platelets: 538×10 9 /L; neutrophils: Following initial management for the tension pneumothorax, a repeat chest radiograph demonstrated lung re-expansion with a small residual pneumothorax, but with no mediastinal shift; peripheral ground glass airspace opacities were accentuated, in keeping with COVID-19 infection (figure 2). keywords: case; chest; covid-19; oxygen; patient; pneumothorax cache: cord-309236-p4c2d5y3.txt plain text: cord-309236-p4c2d5y3.txt item: #1823 of 2876 id: cord-309238-7lbt0f03 author: Koratala, Abhilash title: Need for Objective Assessment of Volume Status in Critically Ill Patients with COVID-19: The Tri-POCUS Approach date: 2020-05-27 words: 2777 flesch: 33 summary: In addition, LUS-derived aeration scores can be used to monitor response to therapy and for prognostication in COVID-19 patients with ARDS [19] . Moreover, FoCUS can be performed in COVID-19 patients undergoing prone ventilation, albeit with a minor modification in the image acquisition technique [22] . keywords: covid-19; fluid; management; patients; status; ultrasound; volume cache: cord-309238-7lbt0f03.txt plain text: cord-309238-7lbt0f03.txt item: #1824 of 2876 id: cord-309302-n6cd2fc3 author: Wang, Li title: Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic date: 2020-09-23 words: 5685 flesch: 42 summary: A study [43] analyzed 1590 patients with COVID-19 as of January 31, 2020, 18 (1%) had a history of cancer, 28% of cancer patient were lung cancer patients. key: cord-309302-n6cd2fc3 authors: Wang, Li; Jiang, Man; Qu, Jialin; Zhou, Na; Zhang, Xiaochun title: Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic date: 2020-09-23 journal: Infect Agent Cancer DOI: 10.1186/s13027-020-00322-7 sha: doc_id: 309302 cord_uid: n6cd2fc3 keywords: cancer; coronavirus; covid-19; epidemic; health; infection; lung; novel; patients; pneumonia; protein; sars; study; symptoms; treatment cache: cord-309302-n6cd2fc3.txt plain text: cord-309302-n6cd2fc3.txt item: #1825 of 2876 id: cord-309323-yflng8m3 author: Thomas, T. title: COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status date: 2020-05-16 words: 6967 flesch: 31 summary: The present study evaluated the serum metabolism of COVID-19 patients (n=33), identified by a positive nucleic acid test of a nasopharyngeal swab, as compared to COVID-19-negative control patients (n=16). Increased circulating levels of glucose and free fatty acids were also observed, consistent with altered carbon homeostasis in COVID-19 patients. keywords: acid; covid-19; figure; il-6; levels; medrxiv; medrxiv preprint; metabolism; patients; perpetuity; preprint; review; sars; subjects; version cache: cord-309323-yflng8m3.txt plain text: cord-309323-yflng8m3.txt item: #1826 of 2876 id: cord-309360-cpis1l4u author: Barrios-López, J. M. title: Ischaemic stroke and SARS-CoV-2 infection: A causal or incidental association? date: 2020-05-28 words: 3155 flesch: 35 summary: Materials and methods We describe the cases of 4 patients with ischaemic stroke and COVID-19 who were attended at our hospital. We also conducted a review of studies addressing the possible mechanisms involved in the aetiopathogenesis of ischaemic stroke in these patients. keywords: causal; cov-2; covid-19; hypercoagulability; ictus; infection; inflammation; patients; sars; stroke; study cache: cord-309360-cpis1l4u.txt plain text: cord-309360-cpis1l4u.txt item: #1827 of 2876 id: cord-309370-g8d3w7it author: Insausti-García, Alfredo title: Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state date: 2020-07-30 words: 2087 flesch: 34 summary: Some studies have shown an incidence of venous and arterial thrombotic events in more than 30% of COVID-19 patients, with venous thromboembolic events being the most common (27%). Parallel to the alteration of coagulation, an exacerbated proinflammatory cytokines response has been observed in Covid-19 patients (CRP, Ferritin, IL-2, IL6, IL-7, IL-10, IP-10, TNFα, etc.), although the cause of this cytokine storm is not yet clear. keywords: covid-19; disease; edema; papillophlebitis; patients; sars cache: cord-309370-g8d3w7it.txt plain text: cord-309370-g8d3w7it.txt item: #1828 of 2876 id: cord-309395-5yan9fcn author: Kazory, Amir title: SARS-CoV-2 (COVID-19) and intravascular volume management strategies in the critically ill date: 2020-04-16 words: 3775 flesch: 30 summary: Constantly reminding ourselves of the currently available evidence on fluid resuscitation strategies, and judiciously applying those principles to the specific features of this disease as we learn them (e.g., high percentage of heart failure, volume overload, and circulatory failure), is likely to help optimize the care of these patients. However, Liu et al showed that after correcting serum creatinine levels for fluid balance, the incidence of AKI was lower with a restrictive fluid strategy. keywords: acute; covid-19; failure; fluid; management; patients; sepsis; shock cache: cord-309395-5yan9fcn.txt plain text: cord-309395-5yan9fcn.txt item: #1829 of 2876 id: cord-309421-725u6dau author: Wechsler, Michael E. title: SOURCE: a phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy and safety of tezepelumab in reducing oral corticosteroid use in adults with oral corticosteroid dependent asthma date: 2020-10-13 words: 5803 flesch: 38 summary: Therefore, asthma treatments that allow a reduction in OCS dose or complete cessation of treatment with OCS, while maintaining control of asthma symptoms, would reduce morbidity and improve patient health-related quality of life (HRQoL). Systematic literature review of systemic corticosteroid use for asthma management Effect of dexamethasone on glucose tolerance and fat metabolism in a diet-induced obesity mouse model High-fat diet and glucocorticoid treatment cause hyperglycemia associated with adiponectin receptor alterations Corticosteroid effects on proximal femur bone loss Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study The cumulative burden of oral corticosteroid side effects and the economic implications of steroid use Doseresponse relationship between long-term systemic corticosteroid use and related complications in patients with severe asthma Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma Oral glucocorticoid-sparing effect of benralizumab in severe asthma Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma TROPOS: designing a clinical trial to evaluate the oral corticosteroid-sparing effect of a biologic in severe asthma Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial Liberty asthma QUEST: phase 3 randomized, double-blind, placebo-controlled, parallel-group study to evaluate dupilumab efficacy/safety in patients with uncontrolled, moderate-to-severe asthma Omalizumab for asthma in adults and children Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity Directional secretory response of double stranded RNA-induced thymic stromal lymphopoetin (TSLP) and CCL11/eotaxin-1 in human asthmatic airways Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: the role of thymic stromal lymphopoietin Tezepelumab in adults with uncontrolled asthma Effects of an anti-TSLP antibody on allergen-induced asthmatic responses Tezepelumab treatment effect on annualized rate of exacerbations by baseline biomarkers in uncontrolled severe asthma patients: phase 2b PATHWAY study Development of a glucocorticoid toxicity index (GTI) using multicriteria decision analysis Tezepelumab granted Breakthrough Therapy Designation by US FDA Accessed 16 Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE trial Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations keywords: asthma; control; dose; effect; ocs; patients; phase; reduction; study; tezepelumab; treatment cache: cord-309421-725u6dau.txt plain text: cord-309421-725u6dau.txt item: #1830 of 2876 id: cord-309441-obojsf04 author: Pirau, Letitia title: Case Series: Evidence of Borderzone Ischemia in Critically-Ill COVID-19 Patients Who “Do Not Wake Up” date: 2020-09-23 words: 2748 flesch: 31 summary: An important problem encountered in the care of COVID-19 patients who require intubation for ARDS and acute hypoxic respiratory failure is prolonged unresponsiveness following discontinuation of sedation (7) . A pro-thrombotic state is well-documented in COVID-19 patients (10, 11) . keywords: admission; covid-19; days; injury; patients; sedation cache: cord-309441-obojsf04.txt plain text: cord-309441-obojsf04.txt item: #1831 of 2876 id: cord-309482-frawgvk7 author: Cook, T. M. title: Kicking on while it’s still kicking off – getting surgery and anaesthesia restarted after COVID‐19 date: 2020-06-01 words: 2673 flesch: 45 summary: Repatriation of these key elements to their proper places in peri-operative pathways is a prerequisite to any return to pre-pandemic levels of planned surgery. However, waiting for 3 months may underestimate the reality, and non-urgent surgery may be delayed much longer. keywords: care; covid-19; need; pandemic; patients; staff; surgery cache: cord-309482-frawgvk7.txt plain text: cord-309482-frawgvk7.txt item: #1832 of 2876 id: cord-309507-oe4i6v5x author: Sacchelli, L. title: Sexually Transmitted Infections during the COVID‐19 outbreak: comparison of patients referring to the service of sexually transmitted diseases during the sanitary emergency with those referring during the common practice date: 2020-06-03 words: 891 flesch: 49 summary: Moreover, the profile of patients and the type of medical provisions required changed. Patients characteristics and medical provisions before and after the lockdown were consistent with the literature 3,6,7 . keywords: lockdown; patients; service cache: cord-309507-oe4i6v5x.txt plain text: cord-309507-oe4i6v5x.txt item: #1833 of 2876 id: cord-309517-yh4d414y author: Yu, Chao title: Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study date: 2020-08-12 words: 3503 flesch: 35 summary: Recently, one report revealed that the rates of virus infection through close contact with symptomatic patients and with asymptomatic patients were 6.30% and 4.11%, respectively [8] . Thus, the exact radiographic characteristics of asymptomatic patients needs further investigation. keywords: asymptomatic; carriers; covid-19; disease; patients; study cache: cord-309517-yh4d414y.txt plain text: cord-309517-yh4d414y.txt item: #1834 of 2876 id: cord-309561-m43v332d author: Cuffaro, Luca title: Dementia care and COVID-19 pandemic: a necessary digital revolution date: 2020-06-17 words: 1414 flesch: 26 summary: Digital triage for people with multiple sclerosis in the age of COVID-19 pandemic COVID-19): Tips for Dementia Caregivers No lockdown for neurological diseases during COVID19 pandemic infection Telemedicine in neurology: telemedicine work Group of the American Academy of neurology update The effect of telemedicine on cognitive decline in patients with dementia Neuropsychological test administration by videoconference: a systematic review and metaanalysis Evaluating the feasibility of frequent cognitive assessment using the Mezurio smartphone app: observational and interview study in adults with elevated dementia risk Feasibility, reliability, and validity of a smartphone based application for the assessment of cognitive function in the elderly Development of a smartphone application for the objective detection of attentional deficits in delirium Emerging roles for telemedicine and smart technologies in dementia care Technology-driven interventions for caregivers of persons with dementia: a systematic review E-care: a telecommunications technology intervention for family caregivers of dementia patients Using smartphones to address the needs of persons with Alzheimer's disease Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Luca Cuffaro and Francesco Di Lorenzo contributed equally to this work. National and International Societies have made several recommendations about dementia care addressed to all dementia patients and their caregivers [2] . keywords: caregivers; dementia; patients; people; telemedicine cache: cord-309561-m43v332d.txt plain text: cord-309561-m43v332d.txt item: #1835 of 2876 id: cord-309706-kikx05dj author: MacDonald, Scott title: Implementing a 2019 coronavirus disease airway management strategy for a provincial critical care and ground transport program date: 2020-06-03 words: 1556 flesch: 38 summary: As an example, the NS provincial strategy for airway management for COVID-19 patients highlights a combined effort of many moving parts culminating in a cohesive plan to manage and transport the sickest patients in the province. LifeFlight had to ensure that they could safely apply these hospital-based recommendations around airway management for COVID-19 patients. EHS, working closely with other clinical leaders within the health authority, used this resource document as a springboard to inform changes to usual practice related to COVID-19. keywords: airway; care; covid-19; management; patients cache: cord-309706-kikx05dj.txt plain text: cord-309706-kikx05dj.txt item: #1836 of 2876 id: cord-309728-7vfotgrr author: Johnson, Kristen M. title: Managing COVID‐19 in Renal Transplant Recipients: A Review of Recent Literature and Case Supporting Corticosteroid‐sparing Immunosuppression date: 2020-05-26 words: 3206 flesch: 31 summary: Very little data are currently available regarding the optimal medical management of renal transplant patients testing positive for SARS-CoV-2 including strategies for reducing or modifying immunosuppression. The authors cited that the use of corticosteroids to maintain immunosuppression in these patients likely increased the risk for these infections and warrants caution with the use of corticosteroids in maintaining immunosuppression for transplant patients with SARS-CoV-2. keywords: cov-2; day; disease; immunosuppression; patients; recipients; sars; transplant cache: cord-309728-7vfotgrr.txt plain text: cord-309728-7vfotgrr.txt item: #1837 of 2876 id: cord-309735-bwa1zo07 author: Cerfolio, Robert J. title: Many Ways to Skin A Cat date: 2020-07-24 words: 595 flesch: 61 summary: Permissive apnea may work in many patients but a large number of Covid-19 patients are already hypercapnic and profoundly hypoxic. Reply to the Editor: Marudi and colleagues have presented an alternative method for performing tracheostomy in Covid -19 patients [1] in response to our article [2] . keywords: cat; patients cache: cord-309735-bwa1zo07.txt plain text: cord-309735-bwa1zo07.txt item: #1838 of 2876 id: cord-309751-7elnvjk3 author: Abdelnasser, Mohammad Kamal title: COVID-19. An update for orthopedic surgeons date: 2020-07-01 words: 5223 flesch: 45 summary: Managing COVID-19 patients with surgical emergencies and trauma with the risk of self-infection have led to a higher degree of anxiety and depression [32] . Suspected or confirmed COVID-19 patients should be isolated in a separate room and should keep at least 6 feet distance from other patients or non-treating staff. keywords: care; covid-19; elective; infection; operating; orthopedic; pandemic; patients; practice; room; surgery; training; trauma cache: cord-309751-7elnvjk3.txt plain text: cord-309751-7elnvjk3.txt item: #1839 of 2876 id: cord-309829-3dlfcy31 author: Parupudi, Tejasvi title: Evidence-based point-of-care technology development during the COVID-19 pandemic date: 2020-11-09 words: 4776 flesch: 40 summary: Diagnostic tests are actively useful and improve patient outcomes only when they are used in the right settings. [8] described emerging diagnostic platforms, developmental phases of diagnostic tests and the role of smartphone capabilities such as connectivity, databasing and onboard hardware in formulating evidencebased disease response for policy makers and healthcare systems worldwide. keywords: blood; care; cov-2; covid-19; detection; disease; patient; point; sars; testing; tests; use cache: cord-309829-3dlfcy31.txt plain text: cord-309829-3dlfcy31.txt item: #1840 of 2876 id: cord-309962-phwq8rsf author: Vetter, Monica Hagan title: Chemotherapy directly followed by PARP inhibition as an alternative to surgery in patients with BRCA- mutated ovarian cancer – a potential management strategy in the era of COVID-19 date: 2020-05-23 words: 726 flesch: 46 summary: Patients with epithelial ovarian cancer (EOC) represent a group of patients with high utilization 48 of healthcare. 2 55 56 Patients with BRCA mutations represent a unique group of EOC patients due to their 57 exquisite platinum-sensitivity and impressive progression-free survival with PARP inhibitor 58 maintenance. keywords: chemotherapy; patients cache: cord-309962-phwq8rsf.txt plain text: cord-309962-phwq8rsf.txt item: #1841 of 2876 id: cord-310001-qng7h5cj author: Tomlins, Jennifer title: Clinical features of 95 sequential hospitalised patients with novel coronavirus 2019 disease (COVID-19), the first UK cohort date: 2020-04-27 words: 1290 flesch: 43 summary: Numerous other case series of hospitalised patients in China have provided valuable insight into the clinical features of disease, risk factors for severity and case fatality rate. Coronavirus Disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up Clinical Characteristics of Coronavirus Disease 2019 in China Olfactory and gustatory dysfunctions as a clinical presentation of mild-tomoderate forms of the coronavirus disease (COVID-19): a multicenter European study Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. keywords: care; days; disease; patients cache: cord-310001-qng7h5cj.txt plain text: cord-310001-qng7h5cj.txt item: #1842 of 2876 id: cord-310010-oxgb6xnv author: Dalmau, Josep title: “Time to recharge” date: 2020-06-11 words: 1024 flesch: 36 summary: The current standard of care is rituximab, but approximately only 50% of patients benefit from it use. It was recently shown that the MYD88 L265P mutation is the most common mutation in patients with Waldenström macroglobulinemia and IgM-monoclonal gammopathy of undetermined significance. keywords: monoclonal; patients; sarcoidosis cache: cord-310010-oxgb6xnv.txt plain text: cord-310010-oxgb6xnv.txt item: #1843 of 2876 id: cord-310069-ay4af6xr author: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? date: 2020-07-21 words: 1249 flesch: 46 summary: key: cord-310069-ay4af6xr authors: Tobin, Martin J. title: Does making a diagnosis of ARDS in COVID-19 patients matter? date: 2020-07-21 journal: Chest DOI: 10.1016/j.chest.2020.07.028 sha: doc_id: 310069 cord_uid: ay4af6xr nan The question Do patients with COVID-19 develop typical ARDS? is arousing fevered debate. Other commentators consider high compliance measurements as grounds for doubting typical ARDS in COVID-19 patients. keywords: ards; covid-19; patients cache: cord-310069-ay4af6xr.txt plain text: cord-310069-ay4af6xr.txt item: #1844 of 2876 id: cord-310084-taaz6mhs author: Fatehi, Poya title: Acute Ischemic and Hemorrhagic Stroke and COVID-19: Case Series date: 2020-10-01 words: 3012 flesch: 49 summary: Evidence from previous studies have indicated that patients with severe coronavirus disease might experience respiratory failure with an urgent need for artificial respiration, and other organ dysfunction [7] . His first symptoms were cough and shortness of breath 1 week before hospitalization when he was referred to an allergy specialist and was diagnosed with coronavirus disease after testing for RT-PCR and a confirmative CT scan of the chest. keywords: blood; brain; coronavirus; covid-19; patient; scan cache: cord-310084-taaz6mhs.txt plain text: cord-310084-taaz6mhs.txt item: #1845 of 2876 id: cord-310117-19qsszns author: Huang, Yao title: Clinical characteristics of 17 patients with COVID-19 and systemic autoimmune diseases: a retrospective study date: 2020-06-16 words: 3706 flesch: 47 summary: Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research. This proportion was significantly higher than the study reported on 1099 patients, 7 presumably because more patients with severe COVID-19 were admitted to Tongji Hospital. keywords: aids; clinical; covid-19; disease; hospital; patients; study; tongji; wuhan cache: cord-310117-19qsszns.txt plain text: cord-310117-19qsszns.txt item: #1846 of 2876 id: cord-310166-gt6icwul author: Yang, Xiang-Hong title: Expert recommendations on blood purification treatment protocol for patients with severe COVID-19(): Recommendation and consensus date: 2020-04-28 words: 3131 flesch: 41 summary: The specific contents include the choice of mode of blood purification treatment, establishment of vascular access, choice of blood purification filter, anticoagulation scheme, treatment dose, and initial parameter settings. Based on the experiences of performing blood purification for patients with severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome combined with the first-line clinical practice of blood purification in the treatment of patients with severe COVID-19, we formulated a process of blood purification treatment for patients with severe COVID-19. keywords: aki; blood; coronavirus; covid-19; patients; purification; step; treatment cache: cord-310166-gt6icwul.txt plain text: cord-310166-gt6icwul.txt item: #1847 of 2876 id: cord-310177-4jw1lkli author: Simcock, R. title: Beyond Performance Status date: 2020-07-16 words: 6167 flesch: 46 summary: An examination of the time-related patient characteristics in the palliative oncology literature Predictive model for survival in patients with advanced cancer Predicting life expectancy in patients with metastatic cancer receiving palliative radiotherapy: the TEACHH model Immunotherapy in nonesmall-cell lung cancer patients with performance status 2: clinical decision making with scant evidence Patient performance status and cancer immunotherapy efficacy: a meta-analysis Analysis of heterogeneity in survival benefit of immunotherapy in oncology according to patient demographics and performance status: a systematic review and meta-analysis of overall survival data Poor-performance status assessment of patients with non-small cell lung cancer remains vague and blurred in the immunotherapy era Impact of performance status on treatment outcomes: a real-world study of advanced urothelial cancer treated with checkpoint inhibitors Immune checkpoint inhibitors in real-world treatment of older adults with nonesmall cell lung cancer Rising to the challenge of multimorbidity Frailty in elderly people Frailty and multimorbidity: a systematic review and meta-analysis Prospective comparison of the Montreal Cognitive Assessment (MoCA) and the Mini Mental State Examination (MMSE) in geriatric oncology Delaying and reversing frailty: a systematic review of primary care interventions The G8 screening tool enhances prognostic value to ECOG performance status in elderly cancer patients: a retrospective, single institutional study Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study Comparison of ECOG/WHO performance status and ASA score as a measure of functional status Frailty in the perioperative setting Handgrip weakness, low fat-free mass, and overall survival in non-small cell lung cancer treated with curative-intent radiotherapy Patient-reported versus objectively-measured physical function and mortality risk among cancer survivors The correlative strength of objective physical assessment against the ECOG performance status assessment in individuals diagnosed with cancer Physical function as a prognostic biomarker among cancer survivors Short physical performance battery, usual gait speed, grip strength and vulnerable elders survey each predict functional decline among older women with breast cancer PRISMA-7: a case-finding tool to identify older adults with moderate to severe disabilities Moving beyond Karnofsky and ECOG Performance Status assessments with new technologies Assessing the older cancer patient International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer Developing a cancer-specific geriatric assessment: a feasibility study Reliability, validity, and feasibility of a computer-based geriatric assessment for older adults with cancer Feasibility of geriatric assessment in community oncology clinics Time to stop saying geriatric assessment is too time consuming Comprehensive geriatric assessment: making the most of the aging years Comprehensive geriatric assessment: a meta-analysis of controlled trials Geriatric assessment-identified deficits in older cancer patients with normal performance status Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO Guideline for Geriatric Oncology Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG) These benefits of a CGA would seem obvious and international guidance for the management of older cancer patients recommends the process as a standard [54, 62, 63] . keywords: assessment; cancer; ecog; frailty; oncology; patients; performance; score; status; treatment cache: cord-310177-4jw1lkli.txt plain text: cord-310177-4jw1lkli.txt item: #1848 of 2876 id: cord-310205-j57x9ke6 author: Alcaide, Maria L. title: Pharyngitis and Epiglottitis date: 2007-06-08 words: 7569 flesch: 39 summary: The role of streptococcus in the pathogenesis of rheumatic fever Rapid diagnosis of pharyngitis caused by group A streptococci Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis Management of acute pharyngitis in adults: reliability of rapid streptococcal tests and clinical findings Treatment failures and carriers: perception or problems? Antibiotics for sore throat Are cephalosporins superior to penicillin for treatment of acute streptococcal pharyngitis? Principles of appropriate antibiotic use of acute pharyngitis in adults Antibiotic treatment of children with sore throat Antibiotic treatment of adults with sore throat by community primary care physicians: a national survey Clinical significance and pathogenesis of viral respiratory infections A collaborative study of the aetiology of acute respiratory infection in Britain 1961-4. keywords: acute; adults; cases; children; disease; fever; gas; group; infection; patients; pharyngitis; streptococcal; therapy; throat; treatment cache: cord-310205-j57x9ke6.txt plain text: cord-310205-j57x9ke6.txt item: #1849 of 2876 id: cord-310240-otf9ruvj author: Prohaska, Stefanie title: Intravenous immunoglobulin fails to improve ARDS in patients undergoing ECMO therapy date: 2018-02-26 words: 3638 flesch: 46 summary: Indeed, in a recent retrospective analysis of 543 patients, high IgG levels were associated with high mortality in sepsis patients [18] . ARDS patients suffer from severe hypoxemia, and extracorporeal membrane oxygenation (ECMO) therapy may be necessary to ensure oxygenation. keywords: ards; control; days; group; ivig; patients; therapy cache: cord-310240-otf9ruvj.txt plain text: cord-310240-otf9ruvj.txt item: #1850 of 2876 id: cord-310405-7fah22nu author: Mathur, Sachin title: Development of an enhanced Acute Care Surgery service in response to the COVID-19 global pandemic: Assessment of clinical patient outcomes and staff psychological well-being date: 2020-06-25 words: 3076 flesch: 50 summary: Low risk patients (no recent travel, contact with COVID-19 patient or fever/respiratory symptoms) underwent surgery in the main OR however anesthetic staff-maintained use of N95 respirators for intubation with standard PPE for surgeons. Early co-ordination with the ID, ER, OR, porters and cleaning departments were able to protocolise the movement of suspect COVID-19 patients to limit staff exposure. keywords: care; covid-19; eacs; patients; service; staff; surgery; team cache: cord-310405-7fah22nu.txt plain text: cord-310405-7fah22nu.txt item: #1851 of 2876 id: cord-310539-8zk3hkgj author: Barengolts, Elena title: PERSEVERE OR PERIL: DIABETES CARE IN TIMES OF COVID-19 date: 2020-08-08 words: 1942 flesch: 42 summary: The other therapies in trials include convalescent plasma (from COVID-19 recovered patients), anti-angiogenic (bevacizumab), thalidomide, and modifiers of the gut microbiome (7) . However, in a retrospective cohort analysis of more than 500,000 adults, only ~30% and ~20% among DM patients had flu and pneumococcal vaccines, respectively, far below the recommendations (11) . keywords: coronavirus; covid-19; diabetes; mortality; patients cache: cord-310539-8zk3hkgj.txt plain text: cord-310539-8zk3hkgj.txt item: #1852 of 2876 id: cord-310597-zy6ckr53 author: Essa, Hani title: Hypertension management in cardio-oncology date: 2020-08-03 words: 4759 flesch: 32 summary: A retrospective analysis of nearly 5000 patients with renal cell carcinoma demonstrated that treatment associated hypertension with sunitinib was significantly and independently associated with improved clinical outcomes. key: cord-310597-zy6ckr53 authors: Essa, Hani; Dobson, Rebecca; Wright, David; Lip, Gregory Y. H. title: Hypertension management in cardio-oncology date: 2020-08-03 journal: J Hum Hypertens DOI: 10.1038/s41371-020-0391-8 sha: doc_id: 310597 cord_uid: zy6ckr53 Cancer is one of the leading causes of death worldwide. keywords: agents; analysis; cancer; hypertension; inhibitors; oncology; patients; risk; treatment; vegf cache: cord-310597-zy6ckr53.txt plain text: cord-310597-zy6ckr53.txt item: #1853 of 2876 id: cord-310661-hrvuhkq9 author: Patell, Rushad title: Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID‐19 date: 2020-07-21 words: 3382 flesch: 37 summary: This article is protected by copyright Factors at admission associated with bleeding risk in medical patients: findings from the IMPROVE investigators Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH Biased estimation of thrombosis rates in cancer studies using the method of Kaplan and Meier Thromboembolism in hospitalized neutropenic cancer patients Predicting risk of venous thromboembolism in hospitalized cancer patients: Utility of a risk assessment tool Prevention of venous thromboembolism in medical patients with enoxaparin: a subgroup analysis of the MEDENOX study Thromboprophylaxis with dalteparin in medical patients: which patients benefit? key: cord-310661-hrvuhkq9 authors: Patell, Rushad; Bogue, Thomas; Bindal, Poorva; Koshy, Anita; Merrill, Mwanasha; Aird, William C; Bauer, Kenneth A; Zwicker, Jeffrey I title: Incidence of thrombosis and hemorrhage in hospitalized cancer patients with COVID‐19 date: 2020-07-21 journal: J Thromb Haemost DOI: 10.1111/jth.15018 sha: doc_id: 310661 cord_uid: hrvuhkq9 BACKGROUND: keywords: cancer; cohort; covid-19; events; incidence; patients; thrombosis cache: cord-310661-hrvuhkq9.txt plain text: cord-310661-hrvuhkq9.txt item: #1854 of 2876 id: cord-310663-504p29hv author: Gambardella, Jessica title: Arginine and Endothelial Function date: 2020-08-06 words: 7203 flesch: 14 summary: Both clinical and preclinical studies are examined, analyzing the effects of arginine supplementation in hypertension, ischemic heart disease, aging, peripheral artery disease, and diabetes mellitus. L-arginine, hereinafter referred to as arginine, is a semi-essential or conditionally essential amino acid, since it can be synthetized by healthy individuals but not by preterm infants On these grounds, based on the positive effects of arginine on endothelial function, we can also speculate that arginine supplementation could be helpful, while not being harmful, for contrasting endothelial dysfunction in COVID-19 patients. keywords: administration; arginase; arginine; cardiovascular; diabetes; disease; dysfunction; effects; endothelial; heart; hypertension; insulin; nitric; oxide; patients; study; supplementation cache: cord-310663-504p29hv.txt plain text: cord-310663-504p29hv.txt item: #1855 of 2876 id: cord-310676-125o0o7x author: Liu, Qibin title: Prediction of the clinical outcome of COVID-19 patients using T lymphocyte subsets with 340 cases from Wuhan, China: a retrospective cohort study and a web visualization tool date: 2020-04-11 words: 2813 flesch: 47 summary: As several other research teams pointed out, the potential risk factors of older age, high SOFA score, and d-dimer greater than 1 µg/L could help clinicians to identify patients with poor prognosis at an early stage 12 . Older patients (>65 years) with comorbidities and ARDS are at increased risk of death 14 . While age and underlying diseases are known risk factors for poor prognosis, patients with a less damaged immune system at the time of hospitalization had higher chance of recovery. keywords: coronavirus; covid-19; lymphocyte; patients; subsets; wuhan cache: cord-310676-125o0o7x.txt plain text: cord-310676-125o0o7x.txt item: #1856 of 2876 id: cord-310685-gi2ycrfk author: Geiling, James title: Critical Care of the Morbidly Obese in Disaster date: 2010-10-31 words: 5095 flesch: 42 summary: Unlike normal events, in which most survivors find their own conveyance to the closest hospital, obese patients will most likely not be able to do that, relying therefore on emergency medical services (EMS). Because of the increased needs and comorbidities of obese patients, they pose additional challenges to this surge strategy. keywords: care; disaster; emergency; health; management; medical; medicine; needs; obesity; patients; resources; support cache: cord-310685-gi2ycrfk.txt plain text: cord-310685-gi2ycrfk.txt item: #1857 of 2876 id: cord-310690-50z2kdaj author: Maschmeyer, Georg title: How to manage lung infiltrates in adults suffering from haematological malignancies outside allogeneic haematopoietic stem cell transplantation date: 2016-01-05 words: 6466 flesch: 21 summary: Diagnostic Microbiology and Infectious Diseases Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period Incidence and prognostic value of respiratory events in acute leukemia ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis Intensive care in patients with newly diagnosed malignancies and a need for cancer chemotherapy Serum galactomannan-based early detection of invasive aspergillosis in hematology patients receiving effective antimold prophylaxis Cytomegalovirus infection and non-neutropenic fever after autologous stem cell transplantation: high rates of reactivation in patients with multiple myeloma and lymphoma The diagnostic value of halo and reversed halo signs for invasive mold infections in compromised hosts Enteral nutrition may cause false-positive results of Aspergillus galactomannan assay in absence of gastrointestinal diseases Human metapneumovirus pneumonia in patients with hematological malignancies The reversed halo sign: update and differential diagnosis Outbreak of Legionnaires' disease in immunosuppressed patients at a cancer centre: usefulness of universal urine antigen testing and early levofloxacin therapy Pneumocystis pneumonia in HIV-infected and immunocompromised non-HIV infected patients: a retrospective study of two centers in China Plasmalyte as a cause of false-positive results for Aspergillus galactomannan in bronchoalveolar lavage fluid Pneumonia in febrile neutropenic patients and in bone marrow and blood stem-cell transplant recipients: use of high-resolution computed tomography Pneumonia in neutropenic patients Fourth European Conference on Infections in Leukaemia (ECIL-4). In patients without a conclusive microbiological finding and a lack of response to antimicrobial treatment, re-assessment including thoracic CT scan and eventually also bronchoscopy and BAL should be arranged after 7 d. Clinical outcome of proven invasive mould infection (aspergillosis or mucormycosis) in neutropenic patients is poor (Lin et al, 2001) , so that early mould-active antifungal treatment should be added to a broad-spectrum anti-pseudomonal beta-lactam in patients whose LI do not have the typical radiological pattern of PcP or lobar bacterial pneumonia (Maschmeyer et al, 2015) . keywords: aspergillus; bal; diagnosis; et al; patients; pneumonia; pulmonary; samples; therapy; treatment cache: cord-310690-50z2kdaj.txt plain text: cord-310690-50z2kdaj.txt item: #1858 of 2876 id: cord-310779-4puiao40 author: Mehta, Pooja title: Telehealth and Nutrition Support During the Covid-19 Pandemic date: 2020-07-14 words: 2357 flesch: 46 summary: Thus it is not surprising that slow 111 internet connection and poor connection to wireless networks negatively impacts communication 112 between health care providers and patients during telehealth visits. 40 One-on-one visits 42 Perhaps one of the most intuitive first steps in using telehealth is to transform existing 43 outpatient one-on-one visits to telehealth visits with an RDN. keywords: care; covid-19; pandemic; patients; providers; telehealth; visits cache: cord-310779-4puiao40.txt plain text: cord-310779-4puiao40.txt item: #1859 of 2876 id: cord-310823-xksu8fn1 author: Anand, Abhinav title: Obesity and mortality in COVID-19: cause or association? date: 2020-09-16 words: 617 flesch: 47 summary: The authors matched the two cohorts for multiple risk factors for mortality; however, the severity of COVID-19 at presentation, which is an important determinant of outcomes, was not matched. In another study of more than 17 million patients, stage 1 obesity was associated with an increased risk {Hazard ratio 1.05 (1.0-1.11)} of mortality when adjusted for other risk factors. keywords: obesity; patients cache: cord-310823-xksu8fn1.txt plain text: cord-310823-xksu8fn1.txt item: #1860 of 2876 id: cord-310891-yfouizjb author: Korada, Sai Krishna C. title: Management of COVID-19 in a Durable Left Ventricular Assist Device Recipient: A Continuity of Care Perspective date: 2020-08-20 words: 1870 flesch: 39 summary: 1 Hypertension, diabetes, and cardiovascular disease increase the risk of adverse outcomes with COVID-19 infection. Management of COVID-19 infection has largely been guided by standard respiratory care, case reports, expert opinion, small randomized clinical trials, and prior experience with SARS-CoV-1, MERS, and H1N1. keywords: covid-19; disease; infection; lvad; management; patient cache: cord-310891-yfouizjb.txt plain text: cord-310891-yfouizjb.txt item: #1861 of 2876 id: cord-310901-oooat8xj author: Arca, Karissa N. title: COVID‐19 and Headache Medicine: A Narrative Review of Non‐Steroidal Anti‐Inflammatory Drug (NSAID) and Corticosteroid Use date: 2020-07-10 words: 4431 flesch: 39 summary: The risks or benefits of steroid use during the COVID-19 pandemic may be dependent on the timing of administration during the disease course. Comparing the data regarding steroid use from prior viral outbreaks and the information available from the current pandemic, it remains unclear if steroids offer benefit or harm when administered to patients with COVID-19. keywords: coronavirus; covid-19; headache; nsaids; pandemic; patients; respiratory; risk; steroids; treatment; use cache: cord-310901-oooat8xj.txt plain text: cord-310901-oooat8xj.txt item: #1862 of 2876 id: cord-310902-cfci8lef author: Freites Nuñez, Dalifer D title: Risk factors for hospital admissions related to COVID-19 in patients with autoimmune inflammatory rheumatic diseases date: 2020-08-07 words: 3989 flesch: 39 summary: To describe patients with autoimmune inflammatory rheumatic diseases (AIRD) who had COVID-19 disease; to compare patients who required hospital admission with those who did not and assess risk factors for hospital admission related to COVID-19. The incidence and severity of COVID-19 disease seem to be higher in patients with risk factors, such as advanced age and associated comorbidities, mainly hypertension, diabetes, heart disease and previous respiratory diseases. keywords: admission; age; covid-19; data; disease; hospital; patients; risk; study cache: cord-310902-cfci8lef.txt plain text: cord-310902-cfci8lef.txt item: #1863 of 2876 id: cord-310917-9sk8gdh8 author: Ahmed, Kamran title: Global challenges to urology practice during the COVID‐19 pandemic date: 2020-05-15 words: 985 flesch: 41 summary: Broadly, urological patients can be divided into three main groups: oncological patients, patients with life-threatening conditions (such as obstructive uropathies) not related to oncology, and benign conditions Subsequently, more resources such as ventilators and personal protective equipment (PPE) can be directed towards patients with coronavirus and secondly elective surgical patients will not unnecessarily be exposed to the virus. keywords: coronavirus; patients; procedures cache: cord-310917-9sk8gdh8.txt plain text: cord-310917-9sk8gdh8.txt item: #1864 of 2876 id: cord-310974-hz37yf39 author: Crolley, Valerie E. title: COVID-19 in cancer patients on systemic anti-cancer therapies: outcomes from the CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London) cohort study date: 2020-10-23 words: 3542 flesch: 43 summary: Alternatively, other studies found that treatment with immunotherapy did not impact mortality negatively in COVID-19 positive cancer patients, 11 and it is hypothesised that immunotherapy may reduce the risk of developing the cytokine storm primarily responsible for the development of ARDS in COVID-19. COVID-19 patients who had received chemotherapy were not more likely to be admitted to ICU (adj. keywords: cancer; covid-19; outcomes; patients; risk; study; treatment cache: cord-310974-hz37yf39.txt plain text: cord-310974-hz37yf39.txt item: #1865 of 2876 id: cord-310976-24b3c3a4 author: Parikh, Neil R. title: Time-Driven Activity-Based Costing Analysis of Telemedicine Services in Radiation Oncology date: 2020-10-01 words: 1640 flesch: 40 summary: From a patient's perspectivedincluding 2 fewer roundtrips to the department (given telemedicine consultation visit and follow-up visits)d232 minutes are saved throughout the entire course of treatment. A modified workflow incorporating telemedicine visits and work-from-home capability conferred savings to a department as well as significant time and costs to health care workers and patients alike. keywords: minutes; patient; telemedicine; time; workflow cache: cord-310976-24b3c3a4.txt plain text: cord-310976-24b3c3a4.txt item: #1866 of 2876 id: cord-311000-abntwzuy author: Sommer, Adir C. title: Telemedicine in ophthalmology in view of the emerging COVID-19 outbreak date: 2020-08-19 words: 7069 flesch: 30 summary: In a recent study on 200 adult glaucoma patients, telemedicine was demonstrated to be equally effective at identifying glaucomatous disease progression, when compared with in-clinic visits, and was supported as having a role in long-term care for glaucoma patients when combined with regular in-person examination, even regardless of special circumstances such as patients residing in distant rural areas, or the current COVID-19 outbreak [64] . Incidental findings while telescreening for diabetic retinopathy The detection of spontaneous venous pulsation with smartphone video ophthalmoscopy Accuracy and Reliability of a Handheld, Nonmydriatic Fundus Camera for the Remote Detection of Optic Disc Edema Diagnosis of retinal detachments by a tele-ophthalmology screening program Teleophthalmology for age-related macular degeneration and diabetic retinopathy screening: a systematic review and meta-analysis Imaging in retinopathy of prematurity Pediatric diabetic retinopathy telescreening Open-angle glaucoma: epidemiology, clinical presentation, and diagnosis Philadelphia telemedicine glaucoma detection and follow-up study: methods and screening results Philadelphia telemedicine glaucoma detection and follow-up study: analysis of unreadable fundus images Telemedicine for glaucoma: Guidelines and Recommendations Telemedicine in long-term care of glaucoma patients Two-year outcomes of a pilot glaucoma suspect telemedicine monitoring program Results from the first teleglaucoma pilot project in Addis Ababa Tele-glaucoma vs clinical evaluation: the New Jersey Health Foundation Prospective Clinical Study Glaucoma screening: where are we and where do we need to go? Acceptability and use of glaucoma virtual clinics in the UK: a national survey of clinical leads Teleophthalmology for anterior segment disease Diagnostic accuracy of technology-based eye care services: the technology-based eye care services compare trial part I Optometry-facilitated teleophthalmology: an audit of the first year in Western Australia Novel use of telemedicine for corneal tissue evaluation in eye banking: establishing a standardized approach for the remote evaluation of donor corneas for transplantation Telemedicine in the correctional setting: a scoping review Military teleconsultation services facilitate prompt recognition and treatment of a case of syphilitic uveitis aboard a United States Navy aircraft carrier at sea during combat operations without evacuation capability Concept and uptake of just-a-minute clinical pearl: a novel tele-ophthalmology teaching tool Informed consent in refractive surgery: in-person vs telemedicine approach Tele-oncology: a validation study of choroidal and iris nevi Tele-ophthalmology for the monitoring of choroidal and iris nevi: a pilot study Robotic remote controlled stereo slit lamp Medical and legal aspects of telemedicine in ophthalmology Evaluating new ophthalmic digital devices for safety and effectiveness in the context of rapid technological development Review of economic evaluations of teleophthalmology as a screening strategy for chronic eye disease in adults Artificial intelligence screening for diabetic retinopathy: the real-world emerging application Artificial intelligence and deep learning in ophthalmology keywords: amd; care; conditions; covid-19; disease; examination; eye; fundus; glaucoma; patients; retinopathy; screening; study; telemedicine; teleophthalmology cache: cord-311000-abntwzuy.txt plain text: cord-311000-abntwzuy.txt item: #1867 of 2876 id: cord-311043-nidu7om2 author: Erdinc, Burak title: Spontaneous Retroperitoneal Bleed Coincided With Massive Acute Deep Vein Thrombosis as Initial Presentation of COVID-19 date: 2020-08-15 words: 2083 flesch: 42 summary: A pneumonia outbreak associated with a new coronavirus of probable bat origin Hypercoagulability of COVID-19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Thrombosis in hospitalized patients with COVID-19 in a New York City Health System Autopsy findings and venous thromboembolism in patients with COVID-19 {Epub ahead of print Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 COVID and coagulation: bleeding and thrombotic manifestations of SARS-CoV2 infection Coagulation abnormalities and thrombosis in patients with Here we present a case of COVID-19 infection that reports both thrombosis and bleeding. keywords: acute; bleeding; covid-19; dic; patients; thrombosis cache: cord-311043-nidu7om2.txt plain text: cord-311043-nidu7om2.txt item: #1868 of 2876 id: cord-311044-kjx0z1hc author: Rubio-Pérez, Inés title: COVID-19: key concepts for the surgeon date: 2020-05-28 words: 4654 flesch: 47 summary: Surgical specialists are facing an unprecedented situation: they must collaborate in the ER or medical wards attending these patients, while still needing to make decisions about surgical patients with probable COVID-19. Several cases of atypical pneumonia of unclear origin were detected. keywords: cases; cov-2; covid-19; disease; health; patients; risk; sars; symptoms; treatment; virus cache: cord-311044-kjx0z1hc.txt plain text: cord-311044-kjx0z1hc.txt item: #1869 of 2876 id: cord-311074-j3fw4dfc author: Alviset, Sophie title: Continuous Positive Airway Pressure (CPAP) face-mask ventilation is an easy and cheap option to manage a massive influx of patients presenting acute respiratory failure during the SARS-CoV-2 outbreak: A retrospective cohort study date: 2020-10-14 words: 4848 flesch: 44 summary: Optimal respiratory support for COVID-19 patients presenting with acute hypoxemic respiratory failure, however, remains unknown. The role of face-mask CPAP in managing acute hypoxemic respiratory failure in COVID-19 patients warrants further investigation in larger prospective studies and comparison with other ways to manage hypoxemic respiratory failure, such as high flow nasal oxygen cannula keywords: covid-19; cpap; failure; hypoxemic; icu; intubation; patients; respiratory; study; ventilation cache: cord-311074-j3fw4dfc.txt plain text: cord-311074-j3fw4dfc.txt item: #1870 of 2876 id: cord-311176-dlwph5za author: Alshahrani, Mohammed S. title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus date: 2018-01-10 words: 3697 flesch: 44 summary: Blood flow (L min −1 ), revolutions per minute, and sweep gas among ECMO patients had a mean (SD) of 3.8 (0.77), 3148.7 ECMO-related mechanical complications occurred in 3 (18%) patients; one patient developed pneumothorax that was treated with chest tube insertion, and two patients had major bleeding immediately after the initiation of ECMO. In regard to infection control issues, caregivers safety of ECMO patients was organized and maintained by aggressive measures which were applied strictly and monitored closely with all admissions were taken to airborne isolated rooms which impacted the containment of the virus plus applying the universal protective personal measures all the time during the patients encounter. keywords: cov; ecmo; group; mers; oxygenation; patients; study; syndrome; use cache: cord-311176-dlwph5za.txt plain text: cord-311176-dlwph5za.txt item: #1871 of 2876 id: cord-311215-x3b7ewo2 author: Chao, Tiffany N. title: Tracheotomy in Ventilated Patients With COVID-19 date: 2020-05-05 words: 2046 flesch: 45 summary: 2. Tracheotomy before 21 days should not be routinely performed in COVID-19 patients solely for prolonged ventilator dependence, given the high risk of transmission and poor prognosis of patients requiring intubation and ventilation in the existing literature. Other indications for tracheotomy in COVID-19 patients should be considered on a caseby-case basis, such as patients with a known difficult airway. keywords: covid-19; days; patients; tracheotomy; ventilation cache: cord-311215-x3b7ewo2.txt plain text: cord-311215-x3b7ewo2.txt item: #1872 of 2876 id: cord-311275-ysr9nqun author: Chuaychoo, Benjamas title: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients date: 2019-07-03 words: 3167 flesch: 38 summary: key: cord-311275-ysr9nqun authors: Chuaychoo, Benjamas; Ngamwongwan, Sopita; Kaewnaphan, Bualan; Athipanyasilp, Niracha; Horthongkham, Navin; Kantakamalakul, Wannee; Muangman, Nisa title: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients date: 2019-07-03 journal: J Clin Virol DOI: 10.1016/j.jcv.2019.07.001 sha: doc_id: 311275 cord_uid: ysr9nqun BACKGROUND: Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients. There were a few data of adult hospitalized patients with RSV infection, with high complications, in Thailand; [3, 12, 13] however, additional clinical data are required for planning patient management and also disease prevention in this region. keywords: acute; adult; infection; patients; pneumonia; rsv; virus cache: cord-311275-ysr9nqun.txt plain text: cord-311275-ysr9nqun.txt item: #1873 of 2876 id: cord-311341-7ox30d2u author: Goenka, Anuj title: Implementation of Telehealth in Radiation Oncology: Rapid Integration During COVID-19 and its Future Role in our Practice date: 2020-10-09 words: 4359 flesch: 43 summary: A HIPAA compliant platform, Amwell Telehealth (American Well Corporation, Boston MA), was selected to deliver telehealth care. Nevertheless, we continue to recommend two-way audio-video encounters as the standard of telehealth care to the extent possible, as J o u r n a l P r e -p r o o f we believe the video aspect of the visit is a very valuable component of being able to offer appropriate clinical advice and establish a patient-physician relationship. keywords: audio; care; patient; person; telehealth; video; visits cache: cord-311341-7ox30d2u.txt plain text: cord-311341-7ox30d2u.txt item: #1874 of 2876 id: cord-311373-ngs7baoc author: Hu, Nannan title: Emergency Management of Mental Hospitals during the Outbreak of COVID-19 date: 2020-05-08 words: 473 flesch: 57 summary: A review of historical classics, research evidence and current prevention programs Online mental health services in China during the COVID-19 outbreak COVID-19 in China chance of infections in hospital. The convenience of internet and smart phones made it possible for psychiatrists and mental health centers to provide online medical care during the COVID-19 epidemic. keywords: covid-19; health cache: cord-311373-ngs7baoc.txt plain text: cord-311373-ngs7baoc.txt item: #1875 of 2876 id: cord-311418-7core0y3 author: Kutsenko, Oleksandra title: Guest Editorial: Radiology Nurses Can Raise the Impact on Promoting IR date: 2020-04-02 words: 445 flesch: 46 summary: key: cord-311418-7core0y3 authors: Kutsenko, Oleksandra title: Guest Editorial: Radiology Nurses Can Raise the Impact on Promoting IR date: 2020-04-02 journal: J Radiol Nurs DOI: 10.1016/j.jradnu.2020.03.003 sha: doc_id: 311418 cord_uid: 7core0y3 nan The second critical focus is to expand the net of healthcare professionals who understand the clinical scenarios and has a good report with patients and other clinicians. They can pre-screen the patients at the emergency rooms and initiate IR consults, maintain long-term comprehensive wound care for patients with chronic limb ischemia, or participate in interdisciplinary tumor boards and provide patient stewardship during oncologic treatments. keywords: patients cache: cord-311418-7core0y3.txt plain text: cord-311418-7core0y3.txt item: #1876 of 2876 id: cord-311579-4jhoatkw author: Bhatt, Harshil title: Venous thromboembolism and COVID-19: a case report and review of the literature date: 2020-10-15 words: 1765 flesch: 42 summary: A novel coronavirus from patients with pneumonia in China Anticoagulation in COVID-19 Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV, and lessons from the past Incidence of venous thromboembolism in hospitalized patients with COVID-19 Humanitas COVID-19 Task Force. The breakdown of these clots leads to elevation of D-dimer levels and fibrin degradation product levels, both of which are associated with poor prognosis in COVID-19 patients, including the need for intensive care unit (ICU) admission, and even death keywords: anticoagulation; coronavirus; covid-19; patient; pulmonary cache: cord-311579-4jhoatkw.txt plain text: cord-311579-4jhoatkw.txt item: #1877 of 2876 id: cord-311673-z4hkw17g author: Uzzan, Mathieu title: Why is SARS-CoV-2 infection more severe in obese men? The gut lymphatics - lung axis hypothesis date: 2020-06-23 words: 2975 flesch: 32 summary: Higher risk of death was further reported for males with cardiovascular comorbidities within COVID-19 ICU patients [3, 4] . Further investigations demonstrated that peripheral inflammatory monocytes and T cells through their production of GM-CSF may incite cytokine storm in severe COVID-19 patients [15, 16] . keywords: cells; covid-19; fat; inflammation; patients; sars; syndrome cache: cord-311673-z4hkw17g.txt plain text: cord-311673-z4hkw17g.txt item: #1878 of 2876 id: cord-311682-npi03i7q author: Malicki, J title: Impact of COVID-19 on the performance of a radiation oncology department at a major comprehensive cancer centre in Poland during the first ten weeks of the epidemic date: 2020-08-16 words: 3221 flesch: 46 summary: Every week thereafter, we reviewed the case mix and status of treated patients based on radiotherapy accepting new patients who met newly elaborated national and international radiotherapy and COVID-19 guidelines. Due to the risk of widespread contagion and the restrictions imposed by the state of epidemic, treatment for medical conditions unrelated to COVID-19 has been severely affected, including radiotherapy for cancer patients. keywords: cancer; covid-19; measures; number; patients; precautionary; radiotherapy; staff cache: cord-311682-npi03i7q.txt plain text: cord-311682-npi03i7q.txt item: #1879 of 2876 id: cord-311730-189vax2m author: Becker, Richard C. title: Covid-19 treatment update: follow the scientific evidence date: 2020-04-27 words: 4518 flesch: 34 summary: The number of clinical trials in Covid-19 patients, either planned or ongoing is increasing on a daily basis. [3] ( On March 28, 2020 the United States Food and Drug Administration (FDA issued) an emergency use authorization (EUA) permitting chloroquine phosphate (medical grade) and hydroxychloroquine sulfate to be added to the strategic national stockpile (SNS) (Fig. 2) . keywords: chloroquine; covid-19; disease; drug; effects; health; hydroxychloroquine; patients; potential; qtc; research; sars; treatment cache: cord-311730-189vax2m.txt plain text: cord-311730-189vax2m.txt item: #1880 of 2876 id: cord-311752-stqrf50k author: Akbariqomi, Mostafa title: Clinical characteristics and outcome of hospitalized COVID-19 patients with diabetes: A single-center, retrospective study in Iran date: 2020-09-24 words: 2629 flesch: 38 summary: A single center study World Health Organization Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019-COVID-NET, 14 States Communicating the risk of death from novel coronavirus disease (COVID-19) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Clinical management of severe acute respiratory infection when novel coronavirus ( 2019-nCoV) infection is suspected: interim guidance Acute Respiratory Distress Syndrome: The Berlin Definition Sex difference and smoking predisposition in patients with COVID-19 ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19 Current smoking, former smoking, and adverse outcome among hospitalized COVID-19 patients: a systematic review and meta-analysis Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis Clinical characteristics and risk factors for mortality of COVID-19 patients with diabetes in Wuhan, China: a two-center, retrospective study Clinical characteristics and outcomes of patients with severe covid-19 with diabetes Clinical characteristics and outcomes of patients with diabetes and COVID-19 in association with glucose-lowering medication Diabetes is a risk factor for the progression and prognosis of COVID-19 The alteration of Th1/Th2/Th17/Treg paradigm in patients with type 2 diabetes mellitus: relationship with diabetic nephropathy Cells of innate and adaptive immunity in type 2 diabetes and obesity COVID-19 and diabetes: Knowledge in progress Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission COVID-19 patients with hypertension have more severe disease: a multicenter retrospective observational study A: chest CT of a 29-year-old male patient without diabetes; B: chest CT from a 49-year-old male patient with diabetes %) Diabetes status of COVID-19 patients and frequent monitoring of glycemia would be helpful to prevent deteriorating clinical conditions. keywords: characteristics; covid-19; diabetes; disease; patients; study cache: cord-311752-stqrf50k.txt plain text: cord-311752-stqrf50k.txt item: #1881 of 2876 id: cord-311816-j8c2lk7y author: D’Elia, Emilia title: Coronavirus Disease 2019: Where are we and Where are we Going? Intersections Between Coronavirus Disease 2019 and the Heart date: 2020-06-29 words: 1703 flesch: 35 summary: This has imposed a significant burden on our hospital in terms of healthcare personnel, dedicated spaces (including intensive care areas) and time spent by clinicians, who are committed to assisting COVID-19 patients. In all this, the fact that comorbidities play a key role in the clinical evolution of COVID-19 patients and affect prognosis has been demonstrated and deserves attention. keywords: cardiac; coronavirus; covid-19; disease; patients cache: cord-311816-j8c2lk7y.txt plain text: cord-311816-j8c2lk7y.txt item: #1882 of 2876 id: cord-311838-ymn96yj4 author: LIU)刘茜玮(, Qianwei title: Analysis of the Influence of the Psychology Changes of Fear Induced by the COVID-19 Epidemic on the Body date: 2020-07-15 words: 4204 flesch: 38 summary: key: cord-311838-ymn96yj4 authors: LIU)刘茜玮(, Qianwei; ZHAO)赵国桢(, Guozhen; JI)嵇波(, Bo; LIU)刘翼天(, Yitian; ZHANG)张靖宇(, Jingyu; MOU)牟秋杰(, Qiujie; SHI)石天宇(, Tianyu title: Analysis of the Influence of the Psychology Changes of Fear Induced by the COVID-19 Epidemic on the Body date: 2020-07-15 journal: World J Acupunct Moxibustion DOI: 10.1016/j.wjam.2020.06.007 sha: doc_id: 311838 cord_uid: ymn96yj4 In this paper, the theory of Fear injury kidney in traditional Chinese medicine is systematically reviewed, and it is found that long-term or excessive psychological changes of fear are likely to damage kidney qi and kidney essence. A new measure designed to assess anticipatory dementia in older adults Design and validation of a new instrument to assess fear of falling in Parkinson's disease Emotional distress impacts fear of the future among breast cancer survivors not the reverse Self-efficacy for labor and childbirth fears in nulliparous pregnant women Validity and time course of surgical fear as measured with with the Surgical Fear Questionnaire in patients undergoing cataract surgery Fear of progression in patients with cancer, diabetes mellitus and chronic arthritis Comparison of self-report and behavioral proceduresfor assessing acrophobia Fear of flying assessment: A contribution to the Italian validation of two self-report measures A fear schedule for use in behavior therapy Exploring the relationship between fear of positive evaluation and social anxiety Measuring co-presence and social presence in virtual environments-psychometric construction of a German scale for a fear of public speaking scenario Annual Review of Cybertherapy and Telemedicine The measurement of fear of crime The Fear of COVID-19 Scale: Development and Initial Validation 58 patients with phobia were mainly treated with acupuncture keywords: anxiety; covid-19; deficiency; epidemic; essence; fear; kidney; patients; psychological cache: cord-311838-ymn96yj4.txt plain text: cord-311838-ymn96yj4.txt item: #1883 of 2876 id: cord-311847-2czqs84q author: Pennisi, Manuela title: SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms date: 2020-07-31 words: 9018 flesch: 36 summary: The differences in the sequence of spike proteins between SARS-CoV and SARS-CoV-2 will enable scientists to identify epitopes in COVID-19 patients for the development of monoclonal antibodies against this virus. COVID-19: Consider cytokine storm syndromes and immunosuppression Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A retrospective analysis The interface between stroke and infectious disease: Infectious diseases leading to stroke and infections complicating stroke The clinical pathology of severe acute respiratory syndrome (SARS): A report from Progression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19 Analysis of the clinical effect of olfactory training on olfactory dysfunction after upper respiratory tract infection Anosmia in COVID-19: A Bumpy Road to Establishing a Cellular Mechanism Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients A Mouse Model of SARS-CoV-2 Infection and Pathogenesis Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences Smell and taste dysfunction in patients with SARS-CoV-2 infection: A review of epidemiology, pathogenesis, prognosis, and treatment options. keywords: ace2; acute; brain; cells; cns; coronavirus; cov-2; covid-19; covs; disease; human; infection; olfactory; patients; sars; study; syndrome; viral cache: cord-311847-2czqs84q.txt plain text: cord-311847-2czqs84q.txt item: #1884 of 2876 id: cord-311848-8n9ee57a author: Giesen, Nicola title: Evidence-based Management of COVID-19 in Cancer Patients – Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) date: 2020-09-21 words: 7686 flesch: 37 summary: 57-60 If caring for COVID-19 patients, we strongly recommend that 185 HCWs wear FFP2/N95 respirators (AII t ) and personal protective equipment including gloves, gowns 186 and eye protection such as goggles or face shields (AII r ). 11 Given that many targeted agents adversely affect immune 303 function we marginally support discontinuation of targeted therapy in COVID-19 patients (CIII). keywords: aii; cancer; cohort; coronavirus; cov-2; covid-19; disease; infection; patients; risk; sars; study; therapy; treatment cache: cord-311848-8n9ee57a.txt plain text: cord-311848-8n9ee57a.txt item: #1885 of 2876 id: cord-311942-oju4gosw author: Grewal, Parneet title: Acute Ischemic Stroke and COVID-19: Experience From a Comprehensive Stroke Center in Midwest US date: 2020-08-20 words: 2746 flesch: 42 summary: Systemic thrombotic complications occurred in 3 (23%) COVID-19 AIS patients. To validate our findings, to further identify mechanisms of stroke and outcome variables, we compared our cohort with stroke patients from the same time frame in 2020 along with historical cohort from 2019. keywords: ais; covid-19; data; group; patients; stroke cache: cord-311942-oju4gosw.txt plain text: cord-311942-oju4gosw.txt item: #1886 of 2876 id: cord-311957-3rmm1hfb author: Faes, C. title: Time between Symptom Onset, Hospitalisation and Recovery or Death: a Statistical Analysis of Different Time-Delay Distributions in Belgian COVID-19 Patients date: 2020-07-21 words: 5796 flesch: 54 summary: key: cord-311957-3rmm1hfb authors: Faes, C.; Abrams, S.; Van Beckhoven, D.; Meyfroidt, G.; Vlieghe, E.; Hens, N. title: Time between Symptom Onset, Hospitalisation and Recovery or Death: a Statistical Analysis of Different Time-Delay Distributions in Belgian COVID-19 Patients date: 2020-07-21 journal: nan DOI: 10.1101/2020.07.18.20156307 sha: doc_id: 311957 cord_uid: 3rmm1hfb Background There are different patterns in the COVID-19 outbreak in the general population and amongst nursing home patients. There are different patterns in the COVID-19 outbreak in the general population and amongst nursing home patients. keywords: age; length; patients; stay; symptom onset; time cache: cord-311957-3rmm1hfb.txt plain text: cord-311957-3rmm1hfb.txt item: #1887 of 2876 id: cord-311970-o9xao5rl author: Ayerbe, Luis title: The association between treatment with heparin and survival in patients with Covid-19 date: 2020-05-31 words: 1858 flesch: 46 summary: However, the use of heparin in Covid-19 patients is still supported by limited evidence. While the nature of the hypoperfusion of lungs in Covid-19 patients is still not fully understood, our findings support that there is a thrombotic component in the development of respiratory distress for these patients keywords: covid-19; heparin; mortality; patients cache: cord-311970-o9xao5rl.txt plain text: cord-311970-o9xao5rl.txt item: #1888 of 2876 id: cord-312012-6a7i72bk author: Scalea, Joseph R. title: The Distancing of Surgeon From Patient in the Era of COVID-19: Bring on the Innovation date: 2020-04-13 words: 1305 flesch: 77 summary: We knew that patients all around the world were dying, and that nearly 200,000 people had already contracted it. In 2020, when blood tests are simply ordered in the computer, seamlessly collected, magically resulted, and acted upon, our inability to determine who was sick and who was not added perceived distance between patient and diagnosis. keywords: barriers; patient; surgeons cache: cord-312012-6a7i72bk.txt plain text: cord-312012-6a7i72bk.txt item: #1889 of 2876 id: cord-312033-iarl77n0 author: López Barreda, Rodrigo title: Poverty, quality of life and psychological wellbeing in adults with congenital heart disease in Chile date: 2020-10-08 words: 4065 flesch: 46 summary: A hypothesis Quality of life of patients with congenital heart diseases Living with CHD: quality of life (QOL) in early adult life Quality of life of adult congenital heart disease patients: a systematic review of the literature Medical factors that predict quality of life for young adults with congenital heart disease: What matters most? Patient-reported outcomes in adults with congenital heart disease: Inter-country variation, standard of living and healthcare system factors Personality traits, quality of life and perceived health in adolescents with congenital heart disease Depression and anxiety in adults with congenital heart disease: a pilot study Psychosocial functioning of the adult with congenital heart disease: a 20-33 years follow-up Hopelessness among adults with congenital heart disease: Cause for despair or hope? key: cord-312033-iarl77n0 authors: López Barreda, Rodrigo; Guerrero, Alonso; de la Cuadra, Juan Cristóbal; Scotoni, Manuela; Salas, Wilbaldo; Baraona, Fernando; Arancibia, Francisca; Uriarte, Polentzi title: Poverty, quality of life and psychological wellbeing in adults with congenital heart disease in Chile date: 2020-10-08 journal: PLoS One DOI: 10.1371/journal.pone.0240383 sha: doc_id: 312033 cord_uid: iarl77n0 The objective of this study was to assess the quality of life and psychological wellbeing of adults with congenital heart disease (CHD) in Chile, and to identify other associated factors. keywords: chd; disease; health; heart; life; patients; qol; quality; study cache: cord-312033-iarl77n0.txt plain text: cord-312033-iarl77n0.txt item: #1890 of 2876 id: cord-312057-4zfaqkxm author: Leppla, Idris E. title: Optimizing Medication Treatment of Opioid Use Disorder During COVID-19 (SARS-CoV-2) date: 2020-05-14 words: 1667 flesch: 45 summary: Another advantage of a video conferencing modality that can accommodate multiple participants (ie, Zoom) is that patients may participate in group sessions with other patients for collective accountability and sharing of experiences. Critical conversations between clinicians and patients, as well as cost-benefit for continued treatment to individual patients is crucial. keywords: buprenorphine; methadone; opioid; patients; treatment cache: cord-312057-4zfaqkxm.txt plain text: cord-312057-4zfaqkxm.txt item: #1891 of 2876 id: cord-312063-5c2w2ct1 author: McCollum, Lauren title: Cognitive Impairment Evaluation and Management date: 2020-08-10 words: 5701 flesch: 37 summary: a systematic review and meta-analysis Sleep and alzheimer disease pathology-a bidirectional relationship Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease Cognitive Impairment Evaluation and Management Mild Cognitive Impairment Report of the Quality Standards Subcommittee of the American Academy of Neurology Neurocognitive aspects of hypothyroidism Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function The diagnosis and management of mild cognitive impairment: a clinical review Diagnosis and management of dementia: review The effects of aging and Alzheimer's disease on cerebral cortical anatomy: specificity and differential relationships with cognition Neuroimaging in dementia Progression of atrophy in Alzheimer's disease and related disorders Cardiovascular risk factors and small vessel disease of the brain: Blood pressure, white matter lesions, and functional decline in older persons Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study A clinicopathological investigation of white matter hyperintensities and alzheimer's disease neuropathology White matter hyperintensities in alzheimer's disease: a lesion probability mapping study Neuroimaging correlates of cerebral microbleeds: the ARIC Study (Atherosclerosis Risk in Communities) Normal pressure hydrocephalus TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia Effect of common neuropathologies on progression of late life cognitive impairment CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis Validation and utilization of amended diagnostic criteria in Creutzfeldt-Jakob disease surveillance High diagnostic accuracy of RT-QuIC assay in a prospective study of patients with suspected sCJD Autoimmune encephalitides and rapidly progressive dementias Rapidly progressive dementia Outcome over seven years of healthy adults with and without subjective cognitive impairment Specific features of subjective cognitive decline predict faster conversion to mild cognitive impairment Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis A comprehensive update on treatment of dementia Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia Acetylcholinesterase inhibitors in Alzheimer's disease Memantine for alzheimer's disease: an updated systematic review and meta-analysis Memantine in moderate-to-severe Alzheimer's disease Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebocontrolled trial (MMM 300) Memantine for dementia Exercise programs for people with dementia Can exercise improve cognitive symptoms of alzheimer's disease? key: cord-312063-5c2w2ct1 authors: McCollum, Lauren; Karlawish, Jason title: Cognitive Impairment Evaluation and Management date: 2020-08-10 journal: Med Clin North Am DOI: 10.1016/j.mcna.2020.06.007 sha: doc_id: 312063 cord_uid: 5c2w2ct1 Clinicians should use a systematic approach to evaluating patients presenting with a concern for cognitive impairment. keywords: cognitive; dementia; diagnosis; disease; impairment; mci; patients; people; risk; sleep; symptoms; treatment cache: cord-312063-5c2w2ct1.txt plain text: cord-312063-5c2w2ct1.txt item: #1892 of 2876 id: cord-312065-nqy7m38f author: Peng, Philip W. H. title: Infection control and anesthesia: Lessons learned from the Toronto SARS outbreak date: 2003 words: 4587 flesch: 60 summary: However, another cluster of SARS patients was discovered on May 23, 2003. In April, a number of health care workers contracted the infection during their care of SARS patients despite increased protective precautions. keywords: acute; anesthesia; care; case; control; health; infection; intubation; patient; sars; syndrome; toronto cache: cord-312065-nqy7m38f.txt plain text: cord-312065-nqy7m38f.txt item: #1893 of 2876 id: cord-312192-hxhohtmj author: Zhu, Lan title: Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China date: 2020-04-18 words: 3426 flesch: 44 summary: Serving as control patients without immunosuppression, the 10 family members with confirmed COVID-19 pneumonia had a mean age of 42.3 AE 14.4 yr, which was similar to that of the infected transplant recipients (45.0 AE 14.0 yr, p > 0.05). To evaluate the clinical features and outcomes of COVID-19 pneumonia in kidney transplant recipients. keywords: chen; covid-19; disease; patients; pneumonia; recipients; transplant cache: cord-312192-hxhohtmj.txt plain text: cord-312192-hxhohtmj.txt item: #1894 of 2876 id: cord-312199-jy3izkou author: Kraus, Kent R. title: Is There Benefit in Keeping Early Discharge Patients Overnight After Total Joint Arthroplasty? date: 2020-07-16 words: 2128 flesch: 41 summary: TJA outpatients receive few, if any, medical interventions prior to discharge, but the type and quantity of medical interventions provided for TJA patients who stay overnight in the hospital is unknown. 90-day all cause readmission rates were similar in patients who received (2.5%) and did not receive (3.3%) a clinical intervention. keywords: arthroplasty; interventions; patients; total cache: cord-312199-jy3izkou.txt plain text: cord-312199-jy3izkou.txt item: #1895 of 2876 id: cord-312209-3yi1w44v author: Bernstein, David N title: Transforming the Orthopaedic Patient Experience Through Telemedicine date: 2020-05-27 words: 1502 flesch: 41 summary: All of this is imperative for optimal orthopaedic patient care, regardless of whether a patient is seen in-person or via telemedicine. Longterm, sustainable orthopaedic telemedicine care is now within reach. keywords: care; orthopaedic; patient; telemedicine cache: cord-312209-3yi1w44v.txt plain text: cord-312209-3yi1w44v.txt item: #1896 of 2876 id: cord-312212-h5j4f0xq author: Dooley, Anjali B. title: Use of Telemedicine for Sexual Medicine Patients date: 2020-07-30 words: 7369 flesch: 48 summary: Telemedicine (TM) will play a significant role in contemporary practices that diagnose and treat sexual medicine patients. The purpose of this article is to improve the understanding of the concept and the trends of using TM to provide care for sexual medicine patients. keywords: face; healthcare; medicine; patients; practice; providers; requirements; services; state; technology; time; use; visit cache: cord-312212-h5j4f0xq.txt plain text: cord-312212-h5j4f0xq.txt item: #1897 of 2876 id: cord-312249-k7dp776s author: Srinivasan, L. title: Split ventilation with pressure regulators for patient-specific tidal volumes date: 2020-07-06 words: 824 flesch: 40 summary: Pressures to each test lung varied between 20 to 38 cmH2O. These data suggest that gas pressure regulators could enable independent tidal volume control during split ventilation, when used with patient-level respiratory monitoring and associated alarms. key: cord-312249-k7dp776s authors: Srinivasan, L.; Rishel, C. A.; Larson, B. J.; Yoo, J.; Shelton, N. title: Split ventilation with pressure regulators for patient-specific tidal volumes date: 2020-07-06 journal: nan DOI: 10.1101/2020.07.03.20145409 sha: doc_id: 312249 cord_uid: k7dp776s As a measure of last resort during the COVID-19 pandemic, single mechanical ventilators have been repurposed to support multiple patients. keywords: patients; pressure; ventilator cache: cord-312249-k7dp776s.txt plain text: cord-312249-k7dp776s.txt item: #1898 of 2876 id: cord-312313-guphuppy author: Patel, Zara M title: Letter: Precautions for Endoscopic Transnasal Skull Base Surgery During the COVID-19 Pandemic date: 2020-04-15 words: 1578 flesch: 44 summary: 3 Healthcare providers are at high risk of infection when taking care of COVID-19 patients without PPE. When endonasal surgery cannot be postponed in a COVID-19 positive patient, based on guidelines now being used in China, we have recommended to our institutional officials that we utilize full powered air purifying respirator (an enclosed powered system with high efficiency particulate air filter), acknowledging that they have challenging decisions surrounding allocation of limited resources that are urgently needed by our critical care teams taking care COVID-19 patients. keywords: colleagues; covid-19; otolaryngology; patients; surgery cache: cord-312313-guphuppy.txt plain text: cord-312313-guphuppy.txt item: #1899 of 2876 id: cord-312388-pc89ybxw author: Singhania, Namrata title: Current Overview on Hypercoagulability in COVID-19 date: 2020-08-04 words: 4218 flesch: 38 summary: That study also compared patients with COVID-19-associated acute respiratory distress syndrome (ARDS) with a matched cohort of non-COVID-19 ARDS patients and found the rate of PE was higher in COVID-19 patients [11.7% vs. 2.1%; odds ratio (OR) 6.2, 95% CI 1.6-23.4; p < 0.008]. Clinical characteristics of coronavirus disease 2019 in China An atypical presentation of novel coronavirus disease 2019 (COVID-19) COVID-19 and coagulopathy: frequently asked questions Endothelial cell infection and endotheliitis in COVID-19 Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 The factor VIII acute phase response requires the participation of NFκB and C/EBP Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans Post-mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction Hypercoagulability of COVID-19 patients in Intensive Care Unit. keywords: acute; anticoagulation; covid-19; dimer; dose; icu; levels; patients; vte cache: cord-312388-pc89ybxw.txt plain text: cord-312388-pc89ybxw.txt item: #1900 of 2876 id: cord-312467-kbhljong author: Boilève, Alice title: COVID-19 management in a cancer center: the ICU storm date: 2020-07-31 words: 4119 flesch: 44 summary: In this regard, some cancer centers have their own ICU (dedicated to cancer patients only) that would receive COVID-19 patients in the context of pandemic. They received a time-limited training resulting in a 2-day observation course with their ICU colleagues before caring ICU patients. keywords: beds; cancer; care; covid-19; hospital; icu; pandemic; patients; workers cache: cord-312467-kbhljong.txt plain text: cord-312467-kbhljong.txt item: #1901 of 2876 id: cord-312486-rumqopg0 author: Jacob, Chaim Oscar title: On the genetics and immunopathogenesis of COVID-19 date: 2020-09-10 words: 11535 flesch: 38 summary: -1 beta in macrophages Influence of glutamine on cytokine production by human gut in vitro Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts A whole-genome association study of major determinants for host control of HIV-1 IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes LY6E impairs coronavirus fusion and confers immune control of viral disease Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients Imbalanced host response to SARS-CoV-2 drives development of COVID-19 Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome Virus-host interactome and proteomic survey of PBMCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis Immunology of COVID-19: current state of the science Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression in patients with severe acute respiratory syndrome Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area Host and environmental factors influencing individual human cytokine responses COVID-19: consider cytokine storm syndromes and immunosuppression A single-cell atlas of the peripheral immune response in patients with severe COVID-19 Inhibition of natural killer cell cytotoxicity by interleukin-6: implications for the pathogenesis of macrophage activation syndrome Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage Dysregulation of immune response in patients with COVID-19 in Wuhan, China Heightened innate immune responses in the respiratory tract of COVID-19 patients Clinical features of patients infected with 2019 novel coronavirus in Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice Complement evasion strategies of viruses: an overview The Complement System in COVID-19: Friend and Foe? Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis Highly pathogenic coronavirus N protein aggravates lung injury by MASP-2-mediated complement over-activation. Functional exhaustion of antiviral lymphocytes in COVID-19 patients Clinical and immunological features of severe and moderate coronavirus disease 2019 Complex immune dysregulation in COVID-19 patients with severe respiratory failure Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent Coronaviruses and immunosuppressed patients: the facts during the third epidemic Uneventful course in patients with inflammatory bowel disease during the severe acute respiratory syndrome coronavirus 2 Outbreak in Northern Italy Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly decimates human spleens and lymph nodes Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implication Longitudinal analyses reveal immunological misfiring in severe COVID-19 Mouse model of SARS-CoV-2 reveals inflammatory role of type I Interferon signaling Persistence of memory in times of COVID-19 Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls No one is naïve: the significance of heterologous T-cell immunity Heterologous immunity between viruses Heterologous T cell immunity in severe hepatitis C virus infection Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing Neutralizing Antibody Responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications Convergent antibody responses to SARS-CoV-2 in convalescent individuals Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 SARS-CoV-2 proteome microarray for global profiling of COVID-19 specific IgG and IgM responses Viral kinetics and antibody responses in patients with COVID-19. keywords: ace2; activation; cells; children; complement; coronavirus; cov-2; covid-19; cytokine; disease; expression; host; human; infection; patients; response; risk; sars; syndrome; system; virus cache: cord-312486-rumqopg0.txt plain text: cord-312486-rumqopg0.txt item: #1902 of 2876 id: cord-312572-i7r28wdc author: Sosnowski, Roman title: Uro-oncology in the era of social distancing: the principles of patient-centered online consultations during the COVID-19 pandemic date: 2020-07-28 words: 3199 flesch: 42 summary: We are aware that this population comprises a heterogeneous group of patients, and while some appointments are simple follow-up visits that can be easily and safely managed online, other patients, especially some new patients or patients presenting with complications may require a physical encounter anyway, but still we believe that online consultations, if performed properly, may play a great role during the ongoing pandemic. These preventive procedures are of particular importance in the elderly and in cancer patients, as this population is at increased risk of serious complications due to COV-ID-19 keywords: care; consultation; pandemic; patient; risk; telemedicine cache: cord-312572-i7r28wdc.txt plain text: cord-312572-i7r28wdc.txt item: #1903 of 2876 id: cord-312609-gv1khfmo author: Fatima, Nida title: Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic date: 2020-08-06 words: 1850 flesch: 38 summary: The inclusion criteria included patients presenting with acute stroke who eventually were found to be positive COVID-19. Our systematic review determined the underlying risk factors leading to stroke among COVID-19 patients, and outcomes among these patients. keywords: covid-19; disease; patients; review; stroke cache: cord-312609-gv1khfmo.txt plain text: cord-312609-gv1khfmo.txt item: #1904 of 2876 id: cord-312614-63qzissw author: Latham, Stephen R. title: Avoiding Ineffective End‐of‐Life Care: A Lesson from Triage? date: 2020-06-29 words: 1163 flesch: 55 summary: The trouble is-and this was spotted in each of the hospitals with which I was involved-that at the moment of triage implementation, there will already be many Covid-19 patients lying in ICU beds and attached to ventilators who would not have been offered those resources under the triage standards. by STEPHEN R. LATHAM L ike many bioethicists, I've been involved in the last few weeks with hospitals' efforts to articulate triage policies-helping to draft one in my own state and consulting with hospitals in two others. keywords: care; patients; triage cache: cord-312614-63qzissw.txt plain text: cord-312614-63qzissw.txt item: #1905 of 2876 id: cord-312632-g4250q6l author: Cai, Xiaofang title: Clinical Characteristics of 5 COVID-19 Cases With Non-respiratory Symptoms as the First Manifestation in Children date: 2020-05-12 words: 4658 flesch: 44 summary: Although the patient had no fever or cough, because of a suspicion of contact history with COVID-19 patients (both parents and grandparents were suspected of having COVID-19), a chest CT scan was performed and showed bilateral lung pneumonia with local consolidation (Figures 5A,B) . Wang et al. reported that 10.1% of adult COVID-19 patients initially presented with diarrhea and nausea 1 to 2 days before the development of fever and dyspnea (10) . keywords: cases; children; coronavirus; cov-2; covid-19; disease; emergency; patients; sars; symptoms cache: cord-312632-g4250q6l.txt plain text: cord-312632-g4250q6l.txt item: #1906 of 2876 id: cord-312677-rwznqiib author: Razmi, Mahdieh title: Immunomodulatory-Based Therapy as a Potential Promising Treatment Strategy against Severe COVID-19 Patients: A Systematic Review date: 2020-08-29 words: 6565 flesch: 33 summary: A single center experience Tocilizumab treatment in severe COVID-19 patients attenuates the inflammatory storm incited by monocyte centric immune interactions revealed by single-cell analysis Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab Off-label use of tocilizumab in patients with SARS-CoV-2 infection Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in severe patients with COVID-19 Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients Interleukin-6 blockade for severe COVID-19 Tocilizumab for the treatment of severe coronavirus disease 2019 Use of Tocilizumab for COVID-19-Induced Cytokine Release Syndrome: A Cautionary Case Report Acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab Tocilizumab for cytokine storm syndrome in COVID-19 pneumonia: an increased risk for candidemia? Use of siltuximab in patients with COVID-19 pneumonia requiring ventilatory support, medRxiv preprint Use of anakinra in severe COVID-19: a case report Targeting the inflammatory cascade with anakinra in moderate to severe COVID-19 pneumonia: case series Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells Treatment of Severe COVID-19 with human Umbilical Cord Mesenchymal Stem Cells Intravenous infusion of human umbilical cord Wharton's jellyderived mesenchymal stem cells as a potential treatment for patients with COVID-19 pneumonia Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19 Effectiveness of convalescent plasma therapy in severe COVID-19 patients Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Treatment With Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Treatment with convalescent plasma for COVID-19 patients in Wuhan, China Use of Convalescent Plasma Therapy in Two COVID-19 Patients with Acute Respiratory Distress Syndrome in Korea High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease Recovery of severely ill COVID-19 patients by intravenous immunoglobulin (IVIG) treatment: A case series Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19 Clinical Efficacy of Intravenous Immunoglobulin Therapy in Critical Patients with COVID-19: WHO, Coronavirus disease 2019 (COVID-19) Situation Report -92 Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China Epidemiology, Pathogenesis, and Control of COVID-19 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in COVID-19: immunopathology and its implications for therapy Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs Influence factors of death risk among COVID-19 patients in Wuhan, China: a hospital-based case-cohort study Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients Clinical features of patients infected with 2019 novel coronavirus in Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Effective treatment of severe COVID-19 patients with tocilizumab COVID-19 infection: the perspectives on immune responses Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure Clinical features and treatment of COVID-19 patients in northeast Chongqing Transplantation of ACE2(-) keywords: case; coronavirus; cov-2; covid-19; covid-19 patients; cytokine; disease; patients; sars; studies; study; therapy; treatment cache: cord-312677-rwznqiib.txt plain text: cord-312677-rwznqiib.txt item: #1907 of 2876 id: cord-312684-3i2r2ahr author: Iba, Toshiaki title: Coagulopathy in COVID‐19 date: 2020-06-18 words: 3637 flesch: 35 summary: [11] reported the reduced antithrombin activities in COVID-19 patients compared to healthy control (85% vs. 99%; p < 0.001), the activity was maintained above 80%. It is not known whether similar criteria are appropriate for COVID-19 patients. keywords: coagulation; coagulopathy; coronavirus; covid-19; infection; patients; sars; syndrome cache: cord-312684-3i2r2ahr.txt plain text: cord-312684-3i2r2ahr.txt item: #1908 of 2876 id: cord-312748-9v2bmbod author: Guo, Zhen title: Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date: 2020-09-04 words: 3126 flesch: 28 summary: In ECMO patients, acquired antithrombin deficiency is a result of hemodilution, initiation of coagulation cascade, and consumption due to the use of heparin. Criteria for antithrombin supplementation in adult ECMO patients are not well defined. keywords: antithrombin; coagulation; coronavirus; covid-19; ecmo; extracorporeal; patients; study; support cache: cord-312748-9v2bmbod.txt plain text: cord-312748-9v2bmbod.txt item: #1909 of 2876 id: cord-312754-3yhxcfr2 author: Allen, Bradley D. title: Society for Cardiovascular Magnetic Resonance (SCMR) guidance for re-activation of cardiovascular magnetic resonance practice after peak phase of the COVID-19 pandemic date: 2020-08-10 words: 3681 flesch: 31 summary: COVID-19 positive patients will generally be at higher risk of transmitting the disease to healthcare workers and other patients. In COVID-19 positive patients, isolated waiting and changing areas are necessary. keywords: cardiovascular; cmr; covid-19; healthcare; imaging; pandemic; patients; research; time; workers cache: cord-312754-3yhxcfr2.txt plain text: cord-312754-3yhxcfr2.txt item: #1910 of 2876 id: cord-312795-0e4esl2o author: Puig-Domingo, M. title: COVID-19 and endocrine diseases. A statement from the European Society of Endocrinology date: 2020-04-11 words: 2639 flesch: 38 summary: Increased risk of morbidity and mortality in patients with diabetes regarding COVID-19 infection Older adults and those with serious chronic medical conditions like heart disease, lung disease, and diabetes are at the highest risk for complications from COVID-19 infection. This is also the case for COVID-19 infection [1] . keywords: covid-19; diabetes; disease; infection; patients; risk cache: cord-312795-0e4esl2o.txt plain text: cord-312795-0e4esl2o.txt item: #1911 of 2876 id: cord-312798-2cbgnv1h author: Varma, Niraj title: HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic date: 2020-06-11 words: 3549 flesch: 29 summary: In COVID-19 patients receiving prior antiarrhythmic therapy, there should be a thorough consideration of risk vs benefit before initiating any QT-prolonging COVID-19 therapies, especially considering their unproven value. Clinical characteristics of Covid-19 in New York City Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) Transient complete heart block in a patient with critical COVID-19 A young woman presenting with a viral prodrome, palpitations, dizziness, and heart block Cardiac and arrhythmic complications in patients with COVID-19 Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) Guidance on minimizing risk of drug-induced ventricular arrhythmia during treatment of COVID-19: a statement from the Canadian Heart Rhythm Society How to protect the protectors: 10 lessons to learn for doctors fighting the COVID-19 coronavirus Inpatient use of mobile continuous telemetry for COVID-19 patients treated with hydroxychloroquine and azithromycin ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry Comparison of QT interval readings in normal sinus rhythm between a smartphone heart monitor and a 12-lead ECG for healthy volunteers and inpatients receiving sotalol or dofetilide A wearable remote monitoring system for the identification of subjects with a prolonged QT interval or at risk for drug-induced long QT syndrome Can smartphone wireless ECGs be used to accurately assess ECG intervals in pediatrics? keywords: care; covid-19; ecg; health; hydroxychloroquine; monitoring; patients; qtc; risk cache: cord-312798-2cbgnv1h.txt plain text: cord-312798-2cbgnv1h.txt item: #1912 of 2876 id: cord-312846-ef7m4875 author: Nerina, Denaro title: Coronavirus Disease 19 (COVID-19) during chemoradiation for locally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) date: 2020-05-14 words: 828 flesch: 47 summary: The choice to continue RT treatment even during COVID 19 infection reflects the most recent indications of the ASTRO-ESTRO Consensus in which it emerged a strong agreement to continue RT in patients with SARS-CoV-2-related mild symptoms who had completed more than two weeks of treatment and an agreement to continue radiotherapy in patients with SARS-CoV-2-related mild symptoms, irrespective to the received treatment at that point. At this time, no clinical HNC-specific data on COVID-19 patients are available -but each choice requires an individualized risk/benefit assessment and a multidisciplinary agreement. keywords: covid-19; patient; treatment cache: cord-312846-ef7m4875.txt plain text: cord-312846-ef7m4875.txt item: #1913 of 2876 id: cord-312847-2cg3ylfl author: Carter, Chris title: COVID-19 Disease: assessment of a critically ill patient date: 2020-06-01 words: 5891 flesch: 44 summary: Part 3: cultural and behavioural factors Critical care outreach: capturing nurses' contributions Communication as a basic skill in critical care COVID-19: a synthesis of clinical experience in UK intensive care settings Clinical guide for the management of critical care patients during the coronavirus pandemic Role of air distribution in SARS transmission during the largest nosocomial outbreak in Hong Kong Clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected Unintentional endotracheal tube cuff deflation during routine checks: a simulation study A nurse's survival guide to critical care Optimizing oxygenation in the mechanically ventilated patient Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients Critical care nursing made incredibly easy Patient Safety: Pulse Oximetry Training Manual Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 140 patients infected by SARS-CoV-2 in Wuhan Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Cardiac monitoring and the use of a systematic approach in interpreting electrocardiogram rhythms Undertaking an accurate and comprehensive assessment of the acutely ill adult Assessing acutely ill patients on general wards Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19 COVID-19: consider cytokine storm syndromes and immunosuppression Best practices for managing pain, sedation and delirium in the mechanically ventilated patient Early mobilization of mechanically ventilated patients. 8 A major change in the assessment process is that COVID-19 patients may be initially assessed by redeployed staff and not a qualified Critical Care Nurse. keywords: assessment; blood; care; clinical; covid-19; disease; pain; patients; position; pressure; risk; score; signs; ventilation cache: cord-312847-2cg3ylfl.txt plain text: cord-312847-2cg3ylfl.txt item: #1914 of 2876 id: cord-312918-iof45k1r author: Ortolani, Claudio title: Hydroxychloroquine and dexamethasone in COVID-19: who won and who lost? date: 2020-09-09 words: 4649 flesch: 40 summary: These three ‘Recovery’ RCTs concluded definitely: (a) that treatment with hydroxychloroquine provides no benefits in patients hospitalized with COVID-19; (b) that treatment with dexamethasone reduced deaths by one-third in COVID-19 patients that were mechanically ventilated, and by one-fifth in patients receiving oxygen only; (c) that the combination of Lopinavir and Ritonavir is not effective in reducing mortality in COVID-19 hospitalized patients. Given the importance of resolving this disparity of opinion, it was essential to carry out randomized and controlled studies on a large sample of COVID-19 patients evaluating the results in relation to the severity of the disease. keywords: clinical; cov-2; covid-19; dexamethasone; hydroxychloroquine; patients; results; sars; study; treatment cache: cord-312918-iof45k1r.txt plain text: cord-312918-iof45k1r.txt item: #1915 of 2876 id: cord-313028-0nhgxoim author: Huang, Chaolin title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China date: 2020-01-24 words: 4834 flesch: 46 summary: KDIGO clinical practice guideline for acute kidney injury CDC definitions for nosocomial infections Association between cardiac injury and mortality in hospitalized patients infected with avian influenza A (H7N9) virus Coronaviruses post-SARS: update on replication and pathogenesis A major outbreak of severe acute respiratory syndrome in Hong Kong Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoVinfected rhesus macaques SARS: systematic review of treatment effects Corticosteroids as adjunctive therapy in the treatment of influenza Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Origin and evolution of pathogenic coronaviruses Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting We acknowledge all health-care workers involved in the diagnosis and treatment of patients in Wuhan; we thank the Chinese National Health Commission for coordinating data collection for patients with 2019-nCoV infection; we thank WHO and the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) for sharing data collection templates publicly on the website; and we thank Prof Chen Wang and Prof George F Gao for guidance in study design and interpretation of results. Plasma levels of IL5, IL12p70, IL15, Eotaxin, and RANTES were similar between healthy adults and patients infected with 2019-nCoV. Further comparison between ICU and non-ICU patients showed that plasma concentrations of IL2, IL7, IL10, GCSF, IP10, MCP1, MIP1A, and TNFα were higher in ICU patients than non-ICU patients. keywords: acute; clinical; coronavirus; data; icu; infection; mers; ncov; novel; patients; respiratory; sars cache: cord-313028-0nhgxoim.txt plain text: cord-313028-0nhgxoim.txt item: #1916 of 2876 id: cord-313082-n3bo9jw1 author: Tenenbein, Paul title: The case for routine screening for SARS-CoV-2 before surgery date: 2020-06-03 words: 3819 flesch: 44 summary: La plupart des interventions chirurgicales nécessitent une intubation/extubation et d'autres interventions médicales générant des aérosols, ce qui augmente le risque de transmission nosocomiale aux travailleurs de la santé qui prennent soin du patient pendant et après la chirurgie. suffisamment précis pour altérer la prise en charge du patient et les précautions de contrôle des infections. keywords: chirurgie; cov-2; covid-19; des; les; patients; que; sars; surgery; test; testing cache: cord-313082-n3bo9jw1.txt plain text: cord-313082-n3bo9jw1.txt item: #1917 of 2876 id: cord-313118-dv5xq2k4 author: Davis, Eric M. title: Neurologic Manifestations of Systemic Disease: Sleep Disorders date: 2020-08-06 words: 6176 flesch: 33 summary: Systemic diseases often have sleep manifestations and this report will help the clinician identify key risk factors linking sleep disorders to systemic diseases so as to optimize the overall care of the patient. This review will introduce the accepted organization of sleep disorders, review important features in history taking and evaluation, and survey the systemic diseases that have important comorbidities with particular sleep disorders. keywords: airway; apnea; cardiovascular; chronic; disease; disorders; insomnia; osa; patients; risk; sleep; syndrome; therapy; treatment; trial cache: cord-313118-dv5xq2k4.txt plain text: cord-313118-dv5xq2k4.txt item: #1918 of 2876 id: cord-313136-ab56mg6j author: Pavoni, Vittorio title: Evaluation of coagulation function by rotation thromboelastometry in critically ill patients with severe COVID-19 pneumonia date: 2020-05-11 words: 2629 flesch: 39 summary: [3] [4] ; moreover, a pooled analysis showed that D-dimer values are considerably higher in COVID-19 patients with severe disease than those without [5] . ROTEM analysis confirms that patients with severe COVID-19 pneumonia had a hypercoagulation state that persisted over time. keywords: coagulation; covid-19; icu; patients; sepsis; time cache: cord-313136-ab56mg6j.txt plain text: cord-313136-ab56mg6j.txt item: #1919 of 2876 id: cord-313227-6zwkfzab author: Scala, Stefania title: Fighting the Host Reaction to SARS-COv-2 in Critically Ill Patients: The Possible Contribution of Off-Label Drugs date: 2020-05-27 words: 3882 flesch: 26 summary: Med Hypotheses Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis CXCR4 knockdown prevents inflammatory cytokine expression in macrophages by suppressing activation of MAPK and NF-kappaB signaling pathways CXCR4 inhibitor attenuates ovalbumin-induced airway inflammation and hyperresponsiveness by inhibiting Th17 and Tc17 cell immune response Plerixafor enables safe, rapid, efficient mobilization of hematopoietic stem cells in sickle cell disease patients after exchange transfusion Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection COVID-19 infection in a patient with multiple sclerosis treated with fingolimod Benefitrisk profile of sphingosine-1-phosphate receptor modulators in relapsing and secondary progressive multiple sclerosis The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. CXCR4-mediated inflammatory responses is based on the efficient chemotaxis function of inflammatory cells, such as neutrophils, lymphocytes, and monocytes (66) . keywords: cells; coronavirus; covid-19; cytokines; immune; infection; lung; macrophages; patients; sars; tnf; virus cache: cord-313227-6zwkfzab.txt plain text: cord-313227-6zwkfzab.txt item: #1920 of 2876 id: cord-313239-0gl43af5 author: Moreno, Courtney C. title: CT colonography’s role in the COVID-19 pandemic: a safe(r), socially distanced total colon examination date: 2020-08-03 words: 2825 flesch: 38 summary: Guidance from the Centers for Disease Control and Prevention and directives from state officials resulted in the postponement of elective procedures including cancer screening at facilities to prevent community spread and to preserve the healthcare workforce, facilities, and personal protective equipment (PPE) for an anticipated surge of COVID-19 patients [2] . Though undesirable at any time, a screening procedure-associated perforation is especially undesirable in the COVID-19 era as it would result in unnecessary hospitalization, utilization of healthcare resources, and potential patient exposure to hospitalized COVID-19 patients. keywords: cancer; colonoscopy; covid-19; ctc; healthcare; pandemic; patients; screening cache: cord-313239-0gl43af5.txt plain text: cord-313239-0gl43af5.txt item: #1921 of 2876 id: cord-313294-ffgo56gl author: Bertsimas, D. title: Personalized Prescription of ACEI/ARBs for Hypertensive COVID-19 Patients date: 2020-11-04 words: 7317 flesch: 41 summary: Pharmacologic treatments for coronavirus disease 2019 (covid-19): a review A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer Estimation and inference of heterogeneous treatment effects using random forests Good or bad: application of raas inhibitors in covid-19 patients with cardiovascular comorbidities Remdesivir in adults with severe covid-19: a randomised, double-blind, placebo-controlled, multicentre trial WHO (2020) The derivation cohort is comprised of data from 2,842 hypertensive patients from HOPE registry's hospitals in Spain and from HM Hospitals, also in Spain is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint Match treated and untreated populations based on clinical features and other treatments. keywords: acei; arbs; covid-19; data; models; morbidity; mortality; patients; preprint; prescription; rate; risk; treatment cache: cord-313294-ffgo56gl.txt plain text: cord-313294-ffgo56gl.txt item: #1922 of 2876 id: cord-313349-ikjivfce author: Finsterer, Josef title: Causes of hypogeusia/hyposmia in SARS‐CoV2 infected patients date: 2020-04-20 words: 1140 flesch: 41 summary: 1 Involvement of only four cranial nerves may be due to non-systematic investigations of cranial nerves but more likely is that patients experiencing visual impairment (cranial nerve II), double vision (cranial nerves III, IV, VI), hypoacusis (cranial nerve VIII), dysphagia, or dysarthria (cranial nerves IX, X) would definitely communicate such complaints. However, the cause of abnormal taste/smelling in COVID-19 patients remains elusive. keywords: cov2; patients; sars; taste cache: cord-313349-ikjivfce.txt plain text: cord-313349-ikjivfce.txt item: #1923 of 2876 id: cord-313353-uwwih8v3 author: Di Tano, Giuseppe title: Late Pulmonary Embolism after COVID-19 Pneumonia despite Adequate Rivaroxaban Treatment date: 2020-06-18 words: 1337 flesch: 35 summary: Autopsy specimens from COVID-19 patients showed that pulmonary arteries at the hilum were free of thromboemboli, whereas small-vessel thrombus formation was seen in the periphery of the lung parenchyma in the majority of cases, supporting the concept of a hypercoagulative status, and a high frequency of pulmonary micro-thrombosis [6, 7] . This case highlights the risk of thrombotic complications after COVID-19 infection, raises some concern about their underlying mechanisms, and supports the use of effective anti-thrombotic therapy. keywords: acute; covid-19; infection; therapy cache: cord-313353-uwwih8v3.txt plain text: cord-313353-uwwih8v3.txt item: #1924 of 2876 id: cord-313468-lloh1b0y author: Fernández‐Aranda, Fernando title: COVID Isolation Eating Scale (CIES): Analysis of the impact of confinement in eating disorders and obesity—A collaborative international study date: 2020-09-20 words: 4656 flesch: 32 summary: The fear of COVID-19 scale: Development and initial validation Diagnostic and statistical manual of mental disorders COVID-19 and eating disorders during confinement: Analysis of factors associated with resilience and aggravation of symptoms Structural equation modelling: Adjudging model fit Intolerance of uncertainty in eating disorders: A systematic review and meta-analysis The psychological impact of the COVID-19 epidemic on college students in China Development and initial validation of the COVID-19 anxiety scale Identity statuses in prebariatric patients with obesity: Associations with eating disorder symptoms, psychological complaints, and coping behaviour? Exploring the ways in which COVID-19 and lockdown has affected the lives of adult patients with anorexia nervosa and their carers Statistical power for the behavioral sciences Addiction psychiatry and COVID-19-impact on patients and service provision Eating disorders during the COVID-19 pandemic and quarantine: An overview of risks and recommendations for treatment and early intervention Coronavirus disease 2019 (COVID-19) and obesity. Factors F1, F2, F3 and F4 were also developed to allow for assessment prior and following COVID-19 confinement. keywords: changes; cies; confinement; covid-19; eating; et al; health; impact; obesity; patients; study cache: cord-313468-lloh1b0y.txt plain text: cord-313468-lloh1b0y.txt item: #1925 of 2876 id: cord-313474-1gux1gsi author: None title: Physicians Abstracts date: 2015-03-20 words: 51535 flesch: 53 summary: TRM at 1 year was 9% in Arm A, and 15% in Arm B and 16% in Arm C. Two year OS and DFS for each arm are: arm A -62.2% and 56%; arm B -68% and 59% and 48% and 48% for arm C. For the 115 pts who received standard risk transplants (i.e., pts with high risk forms of AML, ALL or NHL in 1 o CR, AML in 2 o CR, MDS RA/RCMD, CML in 1 o CP or MM in CR1), 2 year OS and DFS are: arm A -60% and 59%; arm B -74% and 65%; arm C -50% and 50%, with relapse rates at 2 yrs of arm All pts engrafted promptly (median d þ 10, range þ 9 -þ 12).TRM (grade II-IV) at 12mos is 18% (95% CI: 8% -31%). keywords: acute; age; allogeneic; aml; analysis; blood; cd34; cells; chronic; cmv; conclusion; conditioning; data; days; disclosure; disease; donor; dose; follow; graft; group; gvhd; hct; high; hla; hsct; incidence; interest; introduction; leukemia; levels; matched; materials; median; methods; months; mortality; n ¼; non; p ¼; patients; post; pts; range; recipients; relapse; response; results; ric; risk; specific; stem; study; survival; t cells; therapy; time; transplantation; treatment; years cache: cord-313474-1gux1gsi.txt plain text: cord-313474-1gux1gsi.txt item: #1926 of 2876 id: cord-313494-a4pms2ub author: Sampedro, Ana Diez title: COVID-19 and Advanced Practice Registered Nurses (APRNs): Frontline update #1 date: 2020-06-18 words: 3759 flesch: 39 summary: Additionally, there is emerging evidence from the frontline that nurses and other healthcare workers are experiencing significant emotional distress as a result of providing direct patient care during this pandemic. Current physician shortages have exacerbated the need for APRNs to fill vital patient care roles as hospitals across the United States (U.S.) are inundated with sick patients. keywords: aprns; care; coronavirus; covid-19; disease; health; pandemic; patients; practice; use cache: cord-313494-a4pms2ub.txt plain text: cord-313494-a4pms2ub.txt item: #1927 of 2876 id: cord-313528-rp15vi1o author: Wallace, Douglas W. title: An adapted emergency department triage algorithm for the COVID‐19 pandemic date: 2020-08-10 words: 2117 flesch: 35 summary: Government of Canada Respiratory care committee of Chinese Thoracic S. Expert consensus on preventing nosocomial transmission during respiratory care for critically ill patients infected by 2019 novel coronavirus pneumonia Expert recommendations for tracheal intubation in critically ill patients with novel coronavirus disease 2019 Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient Management of Patients with Confirmed 2019-nCoV SARS-Co-V-2 viral load in upper respiratory specimens of infected patients 1-Minute Sit-to-Stand Test: systematic review of procedures, performance, and clinimetric properties Step oximetry test: a validation study Association between hypoxemia and mortality in patients with COVID-19 Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment. 1, 2 Widespread community transmission is occurring in the United States (US) and health systems around the world continue to face challenges in the management of COVID-19 patients. keywords: algorithm; care; coronavirus; covid-19; pandemic; patients; triage cache: cord-313528-rp15vi1o.txt plain text: cord-313528-rp15vi1o.txt item: #1928 of 2876 id: cord-313529-xm76ae08 author: Liu, Wen-Kuan title: Detection of human bocavirus from children and adults with acute respiratory tract illness in Guangzhou, southern China date: 2011-12-14 words: 2970 flesch: 53 summary: HBoV infection has recently attracted increasing attention all over the world. [13] [14] , and only a few papers have described the characteristics of HBoV infection in adult patients [16, 25, 26] . keywords: bocavirus; children; hbov; human; infection; patients; samples; years cache: cord-313529-xm76ae08.txt plain text: cord-313529-xm76ae08.txt item: #1929 of 2876 id: cord-313628-6610z7xk author: Igbinosa, Irogue title: Use of Remdesivir for Pregnant Patients with Severe Novel 2019 Coronavirus Disease date: 2020-08-07 words: 710 flesch: 45 summary: However, recent data demonstrates that dexamethasone may improve outcomes in patients with COVID-19 and thus should also be considered as potential treatment for pregnant patients 7 . Data from a randomized controlled trial during the Ebola epidemic suggests safety of remdesivir in pregnancy 4 ; however, pregnant women have largely been excluded from clinical trials for COVID -19 treatment options 5 . keywords: patients; remdesivir cache: cord-313628-6610z7xk.txt plain text: cord-313628-6610z7xk.txt item: #1930 of 2876 id: cord-313684-61hkogdh author: Samaddar, Arghadip title: Pathophysiology and Potential Therapeutic Candidates for COVID-19: A Poorly Understood Arena date: 2020-09-17 words: 11716 flesch: 34 summary: There are currently four ongoing clinical trials of umifenovir for COVID-19 treatment: one in comparison with the basic treatment 6 , and the other three comparing the effects in combination with oseltamivir 7 , lopinavir/ ritonavir 8 , and carrimycin. Currently, there are no clinically proven antiviral drugs or biologics for the treatment of COVID-19 patients. keywords: acute; antiviral; cells; combination; coronavirus; cov-2; covid-19; covid-19 patients; disease; et al; host; immune; infection; mers; patients; protein; receptors; response; rna; sars; therapy; treatment; trial; viral; virus cache: cord-313684-61hkogdh.txt plain text: cord-313684-61hkogdh.txt item: #1931 of 2876 id: cord-313693-qmkrn7pr author: Wong, Bonnie C. K. title: Possible Role of Aerosol Transmission in a Hospital Outbreak of Influenza date: 2010-11-15 words: 4204 flesch: 42 summary: Pandemic (H1N1) Infection prevention and control in health care for confirmed or suspected cases of pandemic (H1N1) 2009 and influenza-like illnesses Interim guidance on infection control measures for 2009 H1N1 influenza in healthcare settings, including protection of healthcare personnel Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review Surgical mask vs N95 respirator Aerosol Transmission of Influenza • CID 2010:51 (15 November) • 1183 for preventing influenza among health care workers: a randomized trial Novel H1N1 influenza and respiratory protection for health care workers Transmission of influenza A in human beings Evidence of airborne transmission of the severe acute respiratory syndrome virus Temporal-spatial analysis of severe acute respiratory syndrome among hospital inpatients Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units Role of ventilation in airborne transmission of infectious agents in the built environment-a multidisciplinary systematic review Review of aerosol transmission of influenza A virus Aerosol transmission of influenza A virus: a review of new studies Outcomes of adults hospitalized with severe influenza Factors associated with early hospital discharge of adult influenza patients A major outbreak of severe acute respiratory syndrome in Hong Kong Seasonality of influenza A(H3N2) virus: a Hong Kong perspective Lack of cross-immune reactivity against influenza H5N1 from seasonal influenza vaccine in humans Fluent 6.2 user's guide Removal of exhaled particles by ventilation and deposition in a multibed airborne infection isolation room How far droplets can move in indoor environments-revisiting Wells evaporation-falling curve of droplets Exhaled air dispersion distances during noninvasive ventilation via different respironics face masks Noninvasive positive-pressure ventilation: an experimental model to assess air and particle dispersion Exhaled air dispersion during oxygen delivery via a simple oxygen mask The guinea pig as a transmission model for human influenza viruses Transmission of influenza virus via aerosols and fomites in the guinea pig model Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice Measurement of airborne influenza virus in a hospital emergency department Influenza virus in human exhaled breath: an observational study Investigation of a nosocomial outbreak of severe acute respiratory syndrome (SARS) in Toronto, Canada Possible SARS coronavirus transmission during cardiopulmonary resuscitation Why did outbreaks of severe acute respiratory syndrome occur in some hospital wards but not in others? Cross-sectional and longitudinal factors predicting influenza vaccination in Hong Kong Chinese elderly aged 65 and above Willingness of Hong Kong healthcare workers to accept pre-pandemic influenza vaccination at different WHO alert levels: two questionnaire surveys Influenza virus transmission is dependent on relative humidity and temperature Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises Under natural conditions, influenza virus is transmitted predominantly via droplets and direct contact [13] . keywords: aerosol; air; bay; infection; influenza; outbreak; patients; transmission; virus; ward cache: cord-313693-qmkrn7pr.txt plain text: cord-313693-qmkrn7pr.txt item: #1932 of 2876 id: cord-313728-08kwkbmd author: Binda, Barbara title: Follow-up and Management of Kidney Transplant Recipients During the COVID-19 Lockdown: the experience of an Italian Transplant Center, Including Two Cases of COVID-19 Pneumonia date: 2020-06-28 words: 3214 flesch: 34 summary: On April 29 the Italian Medicines Agency states that, in this emergency phase, the use of hydroxychloroquine can be considered in COVID-19 patients of any severity, evaluating the risk/benefit ratio in each individual case. A recent retrospective cohort study in COVID-19 patients showed that early, low-dose, short-term administration of methylprednisolone was associated with better clinical outcomes in patients with severe COVID-19 pneumonia, and should be considered before the occurrence of acute respiratory distress syndrome [17] . keywords: covid-19; disease; infection; kidney; lockdown; patients; recipients; sars; transplant cache: cord-313728-08kwkbmd.txt plain text: cord-313728-08kwkbmd.txt item: #1933 of 2876 id: cord-313785-8tipkksu author: d'Ettorre, Gabriella title: Challenges in the Management of SARS-CoV2 Infection: The Role of Oral Bacteriotherapy as Complementary Therapeutic Strategy to Avoid the Progression of COVID-19 date: 2020-07-07 words: 3790 flesch: 35 summary: The WHO, CDC, and FDA have not taken a position on the use of Tocilizumab in COVID-19, even though China's National Health Commission recommends it for use in COVID-19 patients but only if elevated IL-6 levels are present (15) . The collection of clinical data, examination, and nursing of COVID-19 patients is challenging for the risk of virus transmission. keywords: bacteriotherapy; covid-19; data; group; gut; infection; lung; oral; oxygen; patients; virus cache: cord-313785-8tipkksu.txt plain text: cord-313785-8tipkksu.txt item: #1934 of 2876 id: cord-313836-mcm0xmzw author: Di Micco, Pierpaolo title: Venous Thromboembolism and Its Association with COVID-19: Still an Open Debate date: 2020-09-27 words: 1097 flesch: 20 summary: The molecular biology of coronaviruses Recent insights into emerging coronaviruses SARS to novel coronavirus: Old lessons and new lessons Covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate Acute Pulmonary Embolism and COVID-19 Clotting Factors in COVID-19: Epidemiological Association and Prognostic Values in Different Clinical Presentations in an Italian Cohort Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Autopsy Findings and Venous Thromboembolism in Patients with COVID-19 Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients COVID-19 coagulopathy in Caucasian patients COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Clinical impact of pre-admission antithrombotic therapy in hospitalized patients with COVID-19: A multicenter observational study Is thromboprophylaxis with high-dose enoxaparin really necessary for COVID-19 patients? The prevalence of PE in COVID-19 patients ranges from 15% to 40%; this large difference across clinical studies may be due tothe size and heterogeneity of sample populations, presenting significant differences in clinical characteristics, pre-admission pharmacological treatments and anticoagulation regimens used for VTE prophylaxis during the hospitalization [14] keywords: covid-19; patients; vte cache: cord-313836-mcm0xmzw.txt plain text: cord-313836-mcm0xmzw.txt item: #1935 of 2876 id: cord-313860-mzs3ya0s author: Giulietti, Federico title: Pharmacological Approach to Smoking Cessation: An Updated Review for Daily Clinical Practice date: 2020-06-23 words: 7010 flesch: 45 summary: Smoking cessation reduces subsequent cardiovascular events and mortality. Nicotine replacement therapy (NRT), varenicline, bupropion and cytisine are the main pharmacological strategies available for smoking cessation. keywords: bupropion; cessation; disease; nicotine; nrt; patients; quit; smokers; smoking; symptoms; tobacco; use; varenicline cache: cord-313860-mzs3ya0s.txt plain text: cord-313860-mzs3ya0s.txt item: #1936 of 2876 id: cord-313894-stgx36h5 author: Ürün, Yüksel title: Survey of the Impact of COVID-19 on Oncologists’ Decision Making in Cancer date: 2020-08-05 words: 4287 flesch: 40 summary: The impact of COVID-19 outbreak on uro-oncological practice across Europe: Which burden of activity are we facing ahead? Risks from deferring treatment for genitourinary cancers: A collaborative review to aid triage and management during the COVID-19 pandemic Case fatality rate of cancer patients with COVID-19 in a New York hospital system The experience of treating patients with cancer during the COVID-19 pandemic in China TERAVOLT (Thoracic cancERs international coVid 19 cOLlaboraTion): First results of a global collaboration to address the impact of COVID-19 in patients with thoracic malignancies Managing patients with cancer during the COVID-19 pandemic: Frontline experience from Wuhan Patients with cancer appear more vulnerable to SARS-COV-2: A multicenter study during the COVID-19 outbreak Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China Outcome of cancer patients infected with COVID-19, including toxicity of cancer treatments SARS-CoV-2 transmission in patients with cancer at a tertiary care hospital in Wuhan, China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Caring for patients with cancer in the COVID-19 era European Association of Urology Guidelines Office Rapid Reaction Group: An organisation-wide collaborative effort to adapt the European Association of Urology Guidelines recommendations to the coronavirus disease 2019 era Advice regarding systemic therapy in patients with urological cancers during the COVID-19 pandemic Considerations in the triage of urologic surgeries during the COVID-19 pandemic The shifting landscape of genitourinary oncology during the COVID-19 pandemic and how Italian oncologists reacted: Results from a national survey How to guarantee the best of care to patients with cancer during the COVID-19 epidemic: The Italian experience Oncology practice during the COVID-19 pandemic The COVID-19 and Cancer Consortium (CCC19): A collaborative effort to understand the effects of COVID-19 on patients with cancer Impact of the COVID-19 pandemic on the symptomatic diagnosis of cancer: The view from primary care Lessons from a pooled meta-analysis Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: A population-based study (N = 4532) Impact of anti-androgenic therapies on COVID-19: An observational study in male population from a COVID-19 regional centre of Lombardy (Italy) Treatment of the immune-related adverse effects of immune checkpoint inhibitors: A review Determinants of severity in cancer patients with COVID-19 illness Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients Ethics and resource scarcity: ASCO recommendations for the oncology community during the COVID19 pandemic Crowdsourcing a crisis response for COVID-19 in oncology keywords: cancer; covid-19; oncologists; pandemic; participants; patients; risk; survey; treatment cache: cord-313894-stgx36h5.txt plain text: cord-313894-stgx36h5.txt item: #1937 of 2876 id: cord-313976-q5j5kr1v author: Alaarag, Ahmed title: Clinical and angiographic characteristics of patients with STEMI and confirmed diagnosis of COVID-19: an experience of Tanta University Hospital date: 2020-10-06 words: 3012 flesch: 45 summary: [21] in a study performed in 4 countries in COVID-19 patients with STEMI primary PCI was the treatment strategy in 24% of patients, while fibrinolytic therapy was the treatment in 76% of patients. key: cord-313976-q5j5kr1v authors: Alaarag, Ahmed; Hassan, Timoor; Samir, Sameh; Naseem, Mohamed title: Clinical and angiographic characteristics of patients with STEMI and confirmed diagnosis of COVID-19: an experience of Tanta University Hospital date: 2020-10-06 journal: Egypt Heart J DOI: 10.1186/s43044-020-00103-y sha: doc_id: 313976 cord_uid: q5j5kr1v BACKGROUND: Patients with established cardiovascular diseases have a poor prognosis when affected by the coronavirus disease 2019 (COVID-19). keywords: burden; covid-19; myocardial; patients; stemi; study; thrombus cache: cord-313976-q5j5kr1v.txt plain text: cord-313976-q5j5kr1v.txt item: #1938 of 2876 id: cord-313989-bc7q8swu author: Nicholls, Stephen J. title: Optimising Secondary Prevention and Cardiac Rehabilitation for Atherosclerotic Cardiovascular Disease During the COVID-19 Pandemic: A Position Statement from the Cardiac Society of Australia and New Zealand (CSANZ) # date: 2020-04-30 words: 3648 flesch: 30 summary: International guidelines for the care of CVD patients during the COVID-19 pandemic includes advice to address CVD risk factors and promote recovery [12] , and cardiac rehabilitation programs have well-established efficacy for supporting patients with lifestyle change [13] . Perceived or actual loss commonly results in depression and is more prevalent in CVD patients [31] . keywords: cardiac; cardiovascular; care; covid-19; cvd; health; heart; patients; prevention; risk cache: cord-313989-bc7q8swu.txt plain text: cord-313989-bc7q8swu.txt item: #1939 of 2876 id: cord-314070-8qz23nn4 author: Gubbi, Sriram title: Catecholamine physiology and its implications in patients with COVID-19 date: 2020-10-28 words: 5344 flesch: 24 summary: key: cord-314070-8qz23nn4 authors: Gubbi, Sriram; Nazari, Matthew A; Taieb, David; Klubo-Gwiezdzinska, Joanna; Pacak, Karel title: Catecholamine physiology and its implications in patients with COVID-19 date: 2020-10-28 journal: Lancet Diabetes Endocrinol DOI: 10.1016/s2213-8587(20)30342-9 sha: doc_id: 314070 cord_uid: 8qz23nn4 PPGL are well studied disease processes in which the effects of catecholamines are easily discernible and therefore their potential biochemical and physiological influences in patients with COVID-19 can be explored. keywords: acute; adrenoceptor; catecholamines; covid-19; cytokine; disease; effects; excess; hypertension; patients; ppgl; risk; syndrome cache: cord-314070-8qz23nn4.txt plain text: cord-314070-8qz23nn4.txt item: #1940 of 2876 id: cord-314088-ktj17dvq author: Mancini, Francesca title: Personalized care management for persons with Parkinson's disease: A telenursing solution date: 2020-08-19 words: 2700 flesch: 39 summary: We hypothesized that adding telenursing to usual care could fill a gap in currently available services, including offering patients easy accessibility to a nurse with specific expertise in PD. Some symptoms remain poorly recognized and inadequately treated, which negatively impacts on the quality of life (QoL) of patients and their caregivers. keywords: disease; motor; parkinson; patient; symptoms; telenursing cache: cord-314088-ktj17dvq.txt plain text: cord-314088-ktj17dvq.txt item: #1941 of 2876 id: cord-314106-r3axl3w1 author: Porembskaya, Olga title: Pulmonary Artery Thrombosis: A Diagnosis That Strives for Its Independence date: 2020-07-18 words: 7558 flesch: 36 summary: In this cohort of patients, the combination of PA thrombosis with DVT was registered only in 15-23% and primary PA thrombosis in more than 75% [3, 15] . In this review, we discuss potential mechanisms of PA thrombosis in situ. keywords: activation; branches; cells; endothelial; factor; hypoxia; pa thrombosis; patients; platelet; protein; pulmonary; thrombin; thrombosis; venous cache: cord-314106-r3axl3w1.txt plain text: cord-314106-r3axl3w1.txt item: #1942 of 2876 id: cord-314152-wd153s1g author: Noor, Farha Musharrat title: Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis date: 2020-09-12 words: 4770 flesch: 50 summary: A study of 302 patients from Italy Reply to COVID-19 in persons with haematological cancers: A focus on myeloid neoplasms and risk factors for mortality Clinical characteristics and prognostic factors in COVID-19 patients aged≥ 80 years Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy Baseline chronic comorbidity and mortality in laboratory-confirmed COVID-19 cases: Results from the PRECOVID study in Spain COVID-19: clinical course and outcomes of 36 hemodialysis patients in Spain Clinical course and prognostic factors of COVID-19 infection in an elderly hospitalized population Risk factors for mortality and respiratory support in elderly patients hospitalized with COVID-19 in Korea Neurological diseases as mortality predictive factors for patients with COVID-19: A retrospective cohort study Initial gastrointestinal manifestations in patients with SARS-CoV-2 in 112 patients from veracruz (Southeastern Mexico) Predicting mortality due to SARS-CoV-2: A mechanistic score relating obesity and diabetes to COVID-19 outcomes in Mexico Clinical profile of 100 confirmed COVID-19 patients admitted in dhaka medical college hospital Mortality and survival of COVID-19 Identifying Patients at Greatest risk of mortality due to COVID-19: A new England perspective Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study Characteristics, risk factors and outcomes among the first consecutive 1096 patients diagnosed with COVID-19 Characteristics, comorbidities, 30-day outcome and in-hospital mortality of patients hospitalised with COVID-19 in a Swiss area-a retrospective cohort study Performance of pneumonia severity index and CURB-65 in predicting 30-day mortality in patients with COVID-19 Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort Comparison of confirmed COVID-19 with SARS and MERS cases-clinical characteristics, laboratory findings, radiographic signs and outcomes: A systematic review and meta-analysis Coronavirus: Covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate Age and multimorbidity predict death among COVID-19 patients: results of the SARS-RAS study of the Italian Society of hypertension Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong Predictors of mortality in Middle East respiratory syndrome (MERS) Comorbidity and its impact on 1590 patients with covid-19 in China: A nationwide analysis Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian centre study on tocilizumab versus standard of care This meta-analysis revealed that the mortality rate among COVID-19 patients was highest in the European region and older age, gender, ICU patients, patients with comorbidity had a high risk for case fatality. keywords: analysis; covid-19; disease; factors; mortality; patients; risk; studies; study cache: cord-314152-wd153s1g.txt plain text: cord-314152-wd153s1g.txt item: #1943 of 2876 id: cord-314171-431buxxr author: Dariya, Begum title: Understanding novel COVID-19: its impact on organ failure and risk assessment for diabetic and cancer patients date: 2020-05-06 words: 6905 flesch: 47 summary: Earlier research showed that about 6.7% of SARS patients possessed acute kidney injury (AKI), leading to a mortality of almost 91.7% Organizations around the world debated potential therapeutic strategies for treating COVID-19 patients and public health strategies. keywords: ace2; angiotensin; cells; clinical; coronavirus; cov-2; covid-19; host; patients; protein; r n; receptor; sars; virus cache: cord-314171-431buxxr.txt plain text: cord-314171-431buxxr.txt item: #1944 of 2876 id: cord-314218-6znw9zcz author: Baron, D. M. title: Patient blood management during the COVID–19 pandemic: a narrative review date: 2020-05-06 words: 3409 flesch: 35 summary: The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial Randomized clinical trial of preoperative oral versus intravenous iron in anaemic patients with colorectal cancer Preoperative management of colorectal cancer-induced iron deficiency anemia in clinical practice: data from a large observational cohort Intravenous iron isomaltoside 1000 (Monofer(R)) reduces postoperative anaemia in preoperatively non-anaemic patients undergoing elective or subacute coronary artery bypass graft, valve replacement or a combination thereof: a randomized doubleblind placebo-controlled clinical trial (the PROTECT trial) Effect of ultra-shortterm treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial Intravenous ferric carboxymaltose versus standard care in the management of postoperative anaemia: a prospective, open-label, randomised controlled trial Effect of intravenous ferric carboxymaltose on hemoglobin response among patients with acute isovolemic anemia following gastrectomy: the FAIRY randomized clinical trial Clinical characteristics of coronavirus disease 2019 in China Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Patient blood management in the intensive care unit Safety and efficacy of erythropoiesis-stimulating agents in critically ill patients admitted to the intensive care unit: a systematic review and meta-analysis Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 Time course of hemoglobin concentrations in nonbleeding intensive care unit patients Interventions to prevent iatrogenic anemia: a Laboratory Medicine Best Practices systematic review Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan Old, older, the oldest: red blood cell storage and the potential harm of using older red blood cell concentrates A consensus redefinition of transfusion-related acute lung injury Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Early reports have described mild anaemia in COVID-19 patients admitted to the ICU keywords: anaemia; blood; clinical; covid-19; iron; management; pandemic; patients; surgery cache: cord-314218-6znw9zcz.txt plain text: cord-314218-6znw9zcz.txt item: #1945 of 2876 id: cord-314280-kf2bo06e author: Brissot, Eolia title: Management of patients with acute leukemia during the COVID-19 outbreak: practical guidelines from the acute leukemia working party of the European Society for Blood and Marrow Transplantation date: 2020-06-11 words: 2159 flesch: 38 summary: Moreover, Liang et al. reported that 1% of COVID-19 patients had a history of cancer, higher than that of the overall Chinese population (0.29%), with lung cancer being the most frequently found. Another aspect which may probably be even more relevant in cancer patients is their inability to receive the necessary care in time, under the changed scenario of a viral pandemic management. keywords: acute; allo; case; covid-19; leukemia; patients; risk cache: cord-314280-kf2bo06e.txt plain text: cord-314280-kf2bo06e.txt item: #1946 of 2876 id: cord-314349-rhm1ii3d author: Kraft, Miquel title: Incidence, features, outcome and impact on health system of de-novo abdominal surgical diseases in patients admitted with COVID-19 date: 2020-08-28 words: 2715 flesch: 41 summary: Sub-analyses were performed with a consecutive group of COVID-19 patients admitted during the study period, who did not require surgical consultation. COVID-19 patients might develop de-novo surgical diseases during hospitalization, requiring surgical consultation and treatment. keywords: consultation; covid-19; diseases; icu; patients; surgery cache: cord-314349-rhm1ii3d.txt plain text: cord-314349-rhm1ii3d.txt item: #1947 of 2876 id: cord-314378-cs9ggqwk author: Singh, Prateush title: The Effects of a Novel Global Pandemic (COVID-19) on a Plastic Surgery Department date: 2020-04-29 words: 1425 flesch: 46 summary: According to the National Audit Office, £16 billion is spent on elective NHS care per year, 8 with waiting lists for elective plastic surgery procedures up to 12 months long. We need clarity on the hierarchy of procedures that can be delayed, and such patients should be counseled by appropriate professionals to minimize the psychological outcomes of these cancellations. keywords: covid-19; patients; plastic; procedures cache: cord-314378-cs9ggqwk.txt plain text: cord-314378-cs9ggqwk.txt item: #1948 of 2876 id: cord-314449-ukqux772 author: Curtis, L.T. title: Prevention of hospital-acquired infections: review of non-pharmacological interventions date: 2008-06-02 words: 9002 flesch: 34 summary: 11 Pathogens from hospital water are another underappreciated and underdiagnosed source of hospital infection. Contaminated environmental surfaces (such as bedside rails) are also an under-recognised source of hospital infections. keywords: air; analysis; catheters; cleaning; control; hand; hospital; infections; interventions; mrsa; patients; rates; risk; rooms; studies; study; urinary; use; water cache: cord-314449-ukqux772.txt plain text: cord-314449-ukqux772.txt item: #1949 of 2876 id: cord-314537-8a1vqale author: Guo, Fuzheng title: An effective screening and management process in the outpatient clinic for patients requiring hospitalization during the COVID‐19 pandemic date: 2020-04-21 words: 595 flesch: 41 summary: This process aims to detect asymptomatic patients and suspected patients of COVID-19, to minimize the incidence of nosocomial infections and to prevent hospitals from becoming epidemic foci in the long run. This would be regarded as the basic clinical data in case of hospital admission, and it would also help to identify asymptomatic patients with only radiological abnormalities. keywords: covid-19; patients cache: cord-314537-8a1vqale.txt plain text: cord-314537-8a1vqale.txt item: #1950 of 2876 id: cord-314649-1y3ocvz1 author: Franks, Caroline E title: Elevated Cardiac Troponin I Is Associated with Poor Outcomes in COVID-19 Patients at an Academic Medical Center in Midwestern USA date: 2020-06-02 words: 765 flesch: 42 summary: It showed that patients with modest elevations of cTnI (0.03 -0.09 ng/mL) had an adjusted hazard ratio for mortality of 1.77 compared to those with undetectable cTnI while those with cTnI values > 0.09 ng/mL had a hazard ratio of 3.23 for mortality. key: cord-314649-1y3ocvz1 authors: Franks, Caroline E; Scott, Mitchell G; Farnsworth, Christopher W title: Elevated Cardiac Troponin I Is Associated with Poor Outcomes in COVID-19 Patients at an Academic Medical Center in Midwestern USA date: 2020-06-02 journal: J Appl Lab Med DOI: 10.1093/jalm/jfaa092 sha: doc_id: 314649 cord_uid: 1y3ocvz1 nan Early reports from China suggest that cardiac troponin values > 99th percentile upper reference limit (99th% URL) are powerful predictors of poor outcomes in COVID-19 patients (1, 2) . keywords: ctni; patients cache: cord-314649-1y3ocvz1.txt plain text: cord-314649-1y3ocvz1.txt item: #1951 of 2876 id: cord-314694-g0pes5o3 author: Cortiula, F. title: Managing COVID-19 in the oncology clinic and avoiding the distraction effect date: 2020-03-19 words: 1164 flesch: 42 summary: Nosocomial infections in patients with cancer Features of postoperative immune suppression are reversible with interferon gamma and independent of interleukin-6 pathways Myeloid suppressor cells in cancer and autoimmunity Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Risk of COVID-19 for patients with cancer On the origin and continuing evolution of SARS-CoV-2 surveillance are required to detect possible cases before they can lead to transmission, and the reservoir for the virus must be limited to humans. key: cord-314694-g0pes5o3 authors: Cortiula, F.; Pettke, A.; Bartoletti, M.; Puglisi, F.; Helleday, T. title: Managing COVID-19 in the oncology clinic and avoiding the distraction effect date: 2020-03-19 journal: Ann Oncol DOI: 10.1016/j.annonc.2020.03.286 sha: doc_id: 314694 cord_uid: g0pes5o3 nan The safety and management of cancer patients in the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is urgent and most cancer clinics need to establish a contingency plan. keywords: cancer; cov-2; covid-19; patients cache: cord-314694-g0pes5o3.txt plain text: cord-314694-g0pes5o3.txt item: #1952 of 2876 id: cord-314826-usfvulc2 author: Sharifipour, Ehsan title: Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU date: 2020-09-01 words: 4346 flesch: 38 summary: key: cord-314826-usfvulc2 authors: Sharifipour, Ehsan; Shams, Saeed; Esmkhani, Mohammad; Khodadadi, Javad; Fotouhi-Ardakani, Reza; Koohpaei, Alireza; Doosti, Zahra; EJ Golzari, Samad title: Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU date: 2020-09-01 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05374-z sha: doc_id: 314826 cord_uid: usfvulc2 BACKGROUND: COVID-19 is known as a new viral infection. To date, few studies have investigated bacterial superinfections in COVID-19 patients. keywords: aureus; bacteria; baumannii; covid-19; icu; infections; mortality; patients; staphylococcus; study cache: cord-314826-usfvulc2.txt plain text: cord-314826-usfvulc2.txt item: #1953 of 2876 id: cord-315056-ohyb6oa0 author: Xu, Juanjuan title: Clinical characteristics and outcomes of severe or critical COVID-19 patients presenting no respiratory symptoms or fever at onset date: 2020-10-29 words: 4431 flesch: 48 summary: Due to the varied range of atypical symptoms in COVID-19 patients, it is difficult to diagnose atypical COVID-19 patients simply according to symptoms. key: cord-315056-ohyb6oa0 authors: Xu, Juanjuan; Yin, Zhengrong; Liu, Yu; Wang, Sufei; Duan, Limin; An, Yi; Fan, Jinshuo; Liao, Tingting; Jin, Yang; Chen, Jianguo title: Clinical characteristics and outcomes of severe or critical COVID-19 patients presenting no respiratory symptoms or fever at onset date: 2020-10-29 journal: Engineering (Beijing) DOI: 10.1016/j.eng.2020.09.009 sha: doc_id: 315056 cord_uid: ohyb6oa0 It is difficult to identify suspected cases of atypical patients with coronavirus disease 2019 (COVID-19), and data on severe or critical patients are scanty. keywords: admission; china; coronavirus; covid-19; fever; patients; sars; study; symptoms cache: cord-315056-ohyb6oa0.txt plain text: cord-315056-ohyb6oa0.txt item: #1954 of 2876 id: cord-315116-u7btx7nt author: Cabrera-Tasayco, Fiorella del Pilar title: Biosafety Measures at the Dental Office After the Appearance of COVID-19: A Systematic Review date: 2020-07-27 words: 2894 flesch: 41 summary: In addition, in early April, the American Dental Association (ADA) published guidelines for protective measures in dental offices to maintain biosecurity and thereby minimize the risk of COVID-19 transmission before, during, and after dental care. Therefore, this literature review aims to determine the biosecurity measures required in dental offices after the appearance of COVID-19, seeking to provide dental health personnel with updates on the biosecurity and disinfection standards recommended to date, and their adaptation to the needs and ways of working of each. keywords: care; coronavirus; covid-19; dental; dentistry; health; patient cache: cord-315116-u7btx7nt.txt plain text: cord-315116-u7btx7nt.txt item: #1955 of 2876 id: cord-315149-71bmj5il author: Caballero Bermejo, Antonio F. title: Sarilumab versus standard of care for the early treatment of COVID-19 pneumonia in hospitalized patients: SARTRE: a structured summary of a study protocol for a randomised controlled trial date: 2020-09-16 words: 11238 flesch: 40 summary: Also, it will stick to the recommendations given by the consensus documents of the scientific journals3,4 to improve reliability and value of medical research literature by promoting transparent and accurate reporting of clinical research studies. The Principal Investigator may decide to conduct final analysis of study data at any time, even while some subjects may remain in long-term follow-up. keywords: clinical; consent; covid-19; data; dose; failure; following; il6; intervention; investigator; patients; protocol; sarilumab; soc; sponsor; study; treatment; trial cache: cord-315149-71bmj5il.txt plain text: cord-315149-71bmj5il.txt item: #1956 of 2876 id: cord-315157-2p45frlk author: Donell, Simon T. title: Preparation for the next COVID-19 wave: The European Hip Society and European Knee Associates recommendations date: 2020-08-17 words: 4618 flesch: 46 summary: The theory of second waves is based on the 1918-1920 Spanish flu pandemic, which may have started in a US Army camp in Kansas, a British camp in Etaples in France, or possibly German concentration camps [19] . Close monitoring of the Rt value is essential in predicting the risk of a resurgence or second wave of a pandemic. keywords: arthroplasty; cases; covid-19; elective; hip; knee; orthopaedic; pandemic; patients; recommendations; wave cache: cord-315157-2p45frlk.txt plain text: cord-315157-2p45frlk.txt item: #1957 of 2876 id: cord-315181-emf4i6ir author: Ryoo, Nayoung title: Coping with Dementia in the Middle of the COVID-19 Pandemic date: 2020-10-27 words: 7142 flesch: 33 summary: However, current research report anosmia alone or in combination of parageusia among COVID-19 patients while they showed no significant nasal congestion or rhinorrhea as influenza or rhinovirus. This cytokine storm also triggers embolic cerebrovascular accidents, 14 and Li et al. 28 claims that hypercoagulable status of COVID-19 patients can lead to blood clots in both cerebral arteries and cerebral veins causing stroke and cerebral venous thrombosis. keywords: brain; care; coronavirus; covid-19; delirium; dementia; dementia patients; disease; health; home; infection; pandemic; patients; symptoms cache: cord-315181-emf4i6ir.txt plain text: cord-315181-emf4i6ir.txt item: #1958 of 2876 id: cord-315188-a9pvugjt author: Choi, Min Hyuk title: Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea date: 2020-06-23 words: 4149 flesch: 39 summary: In previous studies of COVID-19 patients [8, 12] , mild cases were defined as patients who experienced mild symptoms, with no manifestations of pneumonia on chest imaging. The use of the triage algorithm and KCDC classification for COVID-19 patients saves medical resources, allowing more efficient treatment and management of patients. keywords: cases; covid-19; disease; group; medical; patients; progression; study; symptoms; treatment cache: cord-315188-a9pvugjt.txt plain text: cord-315188-a9pvugjt.txt item: #1959 of 2876 id: cord-315195-m2xqlct8 author: Alfano, Gaetano title: Peritoneal dialysis in the time of coronavirus disease 2019 date: 2020-07-16 words: 2084 flesch: 39 summary: In addition, PD patients have the advantage of reducing close contact with health-care workers, who can be potentially affected by SARS-CoV-2 infection [5] . As a result, radical changes have been made to the care of PD patients as a consequence of new and emerging COVID-19-related issues (Table 1) . keywords: care; covid-19; dialysis; health; patients cache: cord-315195-m2xqlct8.txt plain text: cord-315195-m2xqlct8.txt item: #1960 of 2876 id: cord-315249-yclnl87n author: Read, R. C. title: Infection in acute exacerbations of chronic bronchitis: a clinical perspective date: 1999-12-31 words: 2662 flesch: 36 summary: Patients with pneumonia treated with high dose penicillin and subsequently shown to be infected with penicillin-resistant pneumococci, showed no increase in severity of outcome compared to patients with sensitive strains (32) . Co-existing cardiopulmonary disease such as ischaemic heart disease, and also diabetes, have been linked to poor outcome in COPD patients (38) . keywords: aecb; chronic; copd; exacerbations; patients; therapy cache: cord-315249-yclnl87n.txt plain text: cord-315249-yclnl87n.txt item: #1961 of 2876 id: cord-315297-o8mwmjql author: Stephens, Elizabeth H. title: COVID-19: Crisis Management in Congenital Heart Surgery date: 2020-04-14 words: 2828 flesch: 35 summary: While each hospital strives to carefully monitor and appropriately care for COVID-19 patients, in-house patients and healthcare providers may be positive prior to symptom onset or knowledge of their status, putting incoming surgical patients and their families at risk. Strategies to limit healthcare personnel exposure during the institution of ECMO and the care of COVID-19 patients on ECMO need also be employed. keywords: care; covid-19; exposure; patients; resources; risk; surgery cache: cord-315297-o8mwmjql.txt plain text: cord-315297-o8mwmjql.txt item: #1962 of 2876 id: cord-315311-azamwuzl author: Grattagliano, Ignazio title: The changing face of family medicine in the covid and post‐covid era date: 2020-06-07 words: 1987 flesch: 36 summary: This is particularly important for elderly and fragile patients (i.e. people with important disabilities and/or multiple chronicity with a significant reduction of autonomy) to whom the FD's approach should consider the different social and health situations: elderly patients living with a caregiver, patients who live alone or in a closed community with or without a family behind them. All rights reserved home care of paucisymptomatic COVID patients, as well as for the post-hospitalization setting for stabilized but not yet healed patients. keywords: care; health; patients; people cache: cord-315311-azamwuzl.txt plain text: cord-315311-azamwuzl.txt item: #1963 of 2876 id: cord-315397-cm3mc7we author: Park, H. C. title: Clinical Outcome of Asymptomatic COVID-19 Infection Among a Large Nationwide Cohort of 5,621 Hospitalized Patients in Korea date: 2020-10-27 words: 1120 flesch: 55 summary: The prediction model for patient mortality was developed through risk factor analysis among asymptomatic patients. The age-adjusted Charlson comorbidity index score (CCIS) was the most potent predictor for patient mortality in asymptomatic patients. keywords: asymptomatic; patients; preprint cache: cord-315397-cm3mc7we.txt plain text: cord-315397-cm3mc7we.txt item: #1964 of 2876 id: cord-315424-i3nnennw author: Willer, Brittany L. title: The otolaryngologist’s and anesthesiologist’s collaborative role in a pandemic: a large quaternary pediatric center’s experience with COVID-19 preparation and simulation date: 2020-06-10 words: 2608 flesch: 31 summary: Since both the pediatric otolaryngologist and anesthesiologist are directly involved in emergency airway interventions, both specialties impact the safety of caring for COVID-19 patients and are a part of overall hospital pandemic preparedness. The following guidelines were developed as pathways for escalating airway expertise in COVID-19 patients: Once the anesthesiology team arrives, they assume all airway responsibilities and determine who remains in the room during endotracheal intubation. keywords: airway; covid-19; management; pandemic; patients; pediatric; team cache: cord-315424-i3nnennw.txt plain text: cord-315424-i3nnennw.txt item: #1965 of 2876 id: cord-315486-pjb5v1tc author: Wu, Xiaojun title: Different Laboratory Abnormalities in COVID-19 Patients with Hypertension or Diabetes date: 2020-09-30 words: 1335 flesch: 39 summary: Are patients with hypertension and diabetes mellitus at increased risk for covid-19 infection? Effect of angiotensinconverting enzyme inhibition and angiotensin ii receptor blockers on cardiac angiotensin-converting enzyme 2 China Medical Treatment Expert Group for C (2020a) Comorbidity and its impact on 1590 patients with covid-19 in China: a nationwide analysis Clinical characteristics of coronavirus disease 2019 in China Risk factors associated with disease severity and length of hospital stay in covid-19 patients Temporal radiographic changes in covid-19 patients: relationship to disease severity and viral clearance Recent advances in immunity and hypertension Renin-angiotensin-aldosterone system inhibitors and risk of covid-19 Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in wuhan Clinical course and risk factors for mortality of adult inpatients with covid-19 in wuhan, China: a retrospective cohort study Sars-cov-2 viral load in upper respiratory specimens of infected patients Acknowledgements We acknowledge all the patients involved in this study, and appreciate all the frontline medical and nursing staff involved in the diagnosis and treatment of patients in Wuhan. What else might explain the poorer clinical outcomes of COVID-19 patients with hypertension or diabetes? To explore this question, we re-analysed the same cohort of 99 COVID-19 patients discharged from the general wards of Renmin Hospital of Wuhan University between 5 February 2020 and 14 March 2020 (Ethics approval No: WDRY2020-K124) (Liu et al. 2020a, b) . keywords: covid-19; diabetes; hypertension; patients cache: cord-315486-pjb5v1tc.txt plain text: cord-315486-pjb5v1tc.txt item: #1966 of 2876 id: cord-315490-xs5v3uc3 author: Kessler, Remi A. title: Neurosurgical management of brain and spine tumors in the COVID-19 era: an institutional experience from the epicenter of the pandemic date: 2020-05-05 words: 3986 flesch: 37 summary: Due to the staggering number of COVID-19 patients, the Mount Sinai Health System has reallocated resources and space for patients who become oxygen dependent and may ultimately require mechanical ventilation. Nevertheless, our institutional experience and subsequent changes to patient management will inevitably differ given that our hospital is located in the epicenter of the pandemic across the US, and faces distinct challenges, including an intensive care unit that is currently at triple its normal full capacity due to COVID-19 patients. keywords: care; cases; coronavirus; covid-19; hospital; management; new; pandemic; patient; tumor cache: cord-315490-xs5v3uc3.txt plain text: cord-315490-xs5v3uc3.txt item: #1967 of 2876 id: cord-315569-e56c5g8h author: Aminian, Ali title: Bariatric Surgical Practice During the Initial Phase of COVID-19 Outbreak date: 2020-04-20 words: 1807 flesch: 40 summary: Another small series of COVID-19 patients reported high morbidity and mortality in surgical patients [1] . The aim of this report is to describe the clinical presentation and outcomes of bariatric surgical patients during the initial phase of COVID-19 outbreak. keywords: covid-19; days; infection; patients; surgery cache: cord-315569-e56c5g8h.txt plain text: cord-315569-e56c5g8h.txt item: #1968 of 2876 id: cord-315574-jq1p5t8w author: Copland, Michael title: Canadian Society of Nephrology COVID-19 Rapid Response Team Home Dialysis Recommendations date: 2020-05-29 words: 4254 flesch: 48 summary: We have also suggested surgical mask use when members of the health team must interact with home dialysis patients due to the high risk of COVID-19 complications in this population. As the presentation of COVID-19 may be atypical in dialysis patients, we have suggested surgical mask use for patients who will be in contact with the health care team. keywords: care; covid-19; dialysis; health; home; mask; patients; team; training cache: cord-315574-jq1p5t8w.txt plain text: cord-315574-jq1p5t8w.txt item: #1969 of 2876 id: cord-315598-qwh72inx author: Mendoza, Jose Luis Accini title: ACTUALIZACION DE LA DECLARACIÓN DE CONSENSO EN MEDICINA CRITICA PARA LA ATENCIÓN MULTIDISCIPLINARIA DEL PACIENTE CON SOSPECHA O CONFIRMACIÓN DIAGNÓSTICA DE COVID-19 date: 2020-10-06 words: 69660 flesch: 31 summary: y los que tienen menos probabilidades de beneficiarse (él «demasiado enfermo»), no prestan suficiente atención a las diferencias entre grupos en términos de la duración de los cuidados intensivos necesarios para lograr resultados. Se recomienda aplicar la escala SOFA al menos cada 48 horas sumado al criterio de fragilidad y años de vida saludables salvados estos criterios podrían ser válidos en pacientes con fallo terapéutico a las medidas óptimas y orientar decisiones de deescalamiento de medidas y de nivel de complejidad de atención cuando la demanda potencial supera la oferta (capacidad y capacidades), estas decisiones deben ser tomadas idealmente en junta médica. keywords: 2019; 2020; acuerdo con; acute; además de; aguda; alto; amci; analysis; análisis de; asociado con; aumento de; bajo; calidad de; care; casos de; clinical; clínica; clínica de; clínicos; comité de; como el; como la; como los; como se; como una; compromiso; con covid-19; con el; con enfermedad; con hipoxemia; con infección; con la; con los; con mayor; con neumonía; con que; con sars; con sdra; con sospecha; con su; con un; condiciones de; considerar la; contar con; contra; control; coronavirus; cov-2; criterios de; crítico con; cual se; cuando se; cuenta la; de acuerdo; de aerosoles; de alta; de amci; de atención; de baja; de cada; de contaminación; de coronavirus; de covid-19; de cuidados; de de; de dificultad; de enfermedad; de esta; de estos; de estudios; de falla; de forma; de hcq; de hipoxemia; de il-6; de infección; de ingreso; de intubación; de la; de los; de manera; de marzo; de menor; de oxígeno; de pacientes; de protección; de salud; de ser; de soporte; de su; de tórax; de un; de ventilación; de vida; deben; del; del virus; dentro; desde el; después de; diagnóstico de; disease; disminución de; disminuir el; disponibilidad de; distress; donde; dosis; dosis de; duración de; durante la; días; días de; el consentimiento; el cual; el de; el diagnóstico; el día; el estudio; el grupo; el inicio; el manejo; el momento; el más; el nivel; el número; el paciente; el pronóstico; el riesgo; el sars; el tiempo; el traslado; el uso; elevación de; embargo; en china; en contra; en cuenta; en el; en este; en la; en los; en salud; en su; en uci; en un; entre el; entre la; entre los; es una; estado de; este; estrategia de; está; evidencia de; evitar la; fin de; final de; fue de; fuera de; fueron; grupo de; hasta el; horas; infección por; inicio de; intensive; la administración; la capacidad; la cual; la decisión; la disponibilidad; la enfermedad; la evidencia; la falla; la hcq; la hipoxemia; la infección; la intubación; la mortalidad; la oxigenación; la pandemia; la presencia; la presión; la relación; la respuesta; la salud; la seguridad; la terapia; la toma; la uci; la utilización; la valoración; la vida; la vía; las; los casos; los cuales; los días; los estudios; los síntomas; luego de; manejo de; mayor; mayoría de; mecánica; medición de; medidas de; mejorar la; mejoría; menor; más de; necesidad de; nivel de; niveles; número de; o por; o se; objetivo de; otros; pacientes con; pacientes covid-19; pacientes críticos; pacientes que; pacientes y; para el; para la; para los; para pacientes; para que; para sars; para su; parte de; patients; pcr; pero; personal de; plasma; por covid-19; por el; por la; por los; por sars; por un; posibilidad de; presión; protocolo de; pueden; pulmonar; punto de; que; que el; que la; que los; que puede; que se; que una; realización de; realizar; recomendación se; recomienda la; recomienda que; reducción de; renal; respiratoria; resultados; retiro de; review; riesgo de; salud y; sars; se debe; se han; se puede; se recomienda; según la; ser; severa; severidad de; shock; si el; si la; si se; sin; sobre el; sobre la; son de; sospecha de; syndrome; síndrome de; tasa de; tener; tener en; teniendo en; tiempo de; tipo de; todos los; tormenta de; trabajadores de; tratamiento de; treatment; uci y; un estudio; un paciente; una; unidad de; uso de; utilizar; ventilation; viral; y al; y cols; y como; y con; y de; y el; y en; y es; y la; y los; y para; y por; y puede; y que; y se; y su; y una cache: cord-315598-qwh72inx.txt plain text: cord-315598-qwh72inx.txt item: #1970 of 2876 id: cord-315696-43wmazxa author: Marinaki, Smaragdi title: A Systematic Review of COVID-19 Infection in Kidney Transplant Recipients: A Universal Effort to Preserve Patients’ Lives and Allografts date: 2020-09-16 words: 6026 flesch: 40 summary: Initial report from the US epicenter Infection in solid-organ transplant recipients COVID-19 in kidney transplant recipients A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement Coronavirus Disease (COVID-19) in Kidney and Liver Transplant Patients: A Single-Center Experience Interleukin-6 receptor antagonist therapy to treat SARS-CoV-2 driven inflammatory syndrome in a kidney transplant recipient Threatening drug-drug interaction in a kidney transplant patient with coronavirus disease 2019 (COVID-19) A catabolic state in a kidney transplant recipient with COVID-19 Immunosuppressive therapy maintenance in a kidney transplant recipient with SARS-CoV-2 pneumonia: A case report A familial cluster, including a kidney transplant recipient Coronavirus disease 2019 in renal transplant recipients: Report of two cases COVID-19) in a Renal Transplant Patient Fatal SARS-CoV-2 infection in a renal transplant recipient COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine COVID-19 in kidney transplant recipients Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation? Should cyclosporine be useful in renal transplant recipients affected by SARS-CoV-2? SARS-CoV-2 infection in kidney transplant recipients: keywords: case; covid-19; disease; infection; kidney; ktx; outcomes; patients; recipients; renal; transplant; transplantation cache: cord-315696-43wmazxa.txt plain text: cord-315696-43wmazxa.txt item: #1971 of 2876 id: cord-315730-fzgxuak7 author: Penman, Sophie L. title: Safety perspectives on presently considered drugs for the treatment of COVID‐19 date: 2020-07-17 words: 12087 flesch: 30 summary: As such, it is likely that many of the AEs observed in the Ebola study will translate to COVID-19 patients treated with remdesivir. However, a recent study found that only 4.1 % of COVID-19 patients receiving remdesivir treatment suffered serious (grade 3 or 4) transaminase elevations, with there being no significant difference between the remdesivir-and placebo-treated groups (Beigel et al., 2020) . keywords: anakinra; arthritis; baricitinib; coronavirus; cov-2; covid-19; covid-19 patients; disease; dose; drug; et al; hydroxychloroquine; ifn; infection; liver; patients; potential; remdesivir; rheumatoid; risk; safety; sars; study; tocilizumab; treatment; trial; use cache: cord-315730-fzgxuak7.txt plain text: cord-315730-fzgxuak7.txt item: #1972 of 2876 id: cord-315834-ashjw2xs author: Guo, Lingxi title: Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: The MuLBSTA Score date: 2019-12-03 words: 4029 flesch: 42 summary: Viral pneumonia patients were classified into two groups: survival group and 90-day death group. The mean age of viral pneumonia patients was 63.56 (SD 19.08) years and 61.2% were male. keywords: influenza; mortality; patients; pneumonia; risk; score; study cache: cord-315834-ashjw2xs.txt plain text: cord-315834-ashjw2xs.txt item: #1973 of 2876 id: cord-315871-anguylf1 author: Aschendorff, A. title: Quality of cochlear implant rehabilitation under COVID-19 conditions date: 2020-10-09 words: 3989 flesch: 42 summary: The importance of exchange among rehabilitation patients was evaluated, as was the reduction in contacts resulting from the hygiene measures. The majority of the rehabilitation patients (55.3%) considered conversations with other rehabilitation patients important or very important. keywords: coronavirus; hygiene; measures; pandemic; patients; rehabilitation; therapy cache: cord-315871-anguylf1.txt plain text: cord-315871-anguylf1.txt item: #1974 of 2876 id: cord-315970-m5o962yw author: Di Ciaula, Agostino title: COVID‐19, internists and resilience: the north‐south Italy outbreak. date: 2020-06-01 words: 3986 flesch: 44 summary: On May 20, infected subjects were 26,596 and COVID-19 related deaths were 2,454, about 7-and 12-fold lower, respectively, than in northern Italy. The staff was therefore re-located in the so-called grey zone equipped with up to 64 beds, occupying the whole 5th floor of the Asclepios block, a 5-floor building entirely dedicated to COVID-19 patients (Figure 4) . keywords: article; covid-19; deaths; health; infection; italy; northern; number; patients; subjects cache: cord-315970-m5o962yw.txt plain text: cord-315970-m5o962yw.txt item: #1975 of 2876 id: cord-316003-xt59voyt author: Say, Daphne S. title: Risk Stratification and Personal Protective Equipment Use in Pediatric Endoscopy During the Coronavirus Disease 2019 Outbreak: A Single-center Protocol date: 2020-03-31 words: 1468 flesch: 35 summary: At the same time, we also recognize the need to conserve PPE and other needed resources in anticipation of the surge of COVID-19 patients that require hospitalization. We describe our center's methodology for pediatric patient risk stratification to facilitate responsible use of endoscopic resources during this crisis. keywords: endoscopy; patients; procedures; risk cache: cord-316003-xt59voyt.txt plain text: cord-316003-xt59voyt.txt item: #1976 of 2876 id: cord-316029-z708c3ex author: Brunsdon, Priya title: Clinical Pharmacology Considerations for Developing Small‐Molecule Treatments for COVID‐19 date: 2020-07-12 words: 4969 flesch: 32 summary: A systematic review Gentamicin volume of distribution in critically ill septic patients Antimicrobial pharmacokinetic and pharmacodynamic issues in the critically ill with severe sepsis and septic shock Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics The Impact of Renal Impairment on Patient Drug Response -Assessing the Need for a Consensus Approach Acute kidney injury in patients hospitalized with COVID-19 Kidney involvement in COVID-19 and rationale for extracorporeal therapies COVID-19 and kidney failure in the acute care setting: our experience from Seattle Pharmacokinetic principles during continuous renal replacement therapy: drugs and dosage Assessment of the impact of renal impairment on systemic exposure of new molecular entities: evaluation of recent new drug applications Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection Virological assessment of hospitalized patients with COVID-2019 Working to supply remdesivir for COVID-19 Inhalation drug delivery devices: technology update A review of nebulized drug delivery in COPD Determination of the relative bioavailability of salbutamol to the lungs and systemic circulation following nebulization Practical strategies for a safe and effective delivery of aerosolized medications to patients with COVID-19 A guide to drug therapy in patients with enteral feeding tubes: dosage form selection and administration methods Therapeutic concerns when oral medications are administered nasogastrically Clogged feeding tubes: a clinician's thorn Medication administration through enteral feeding tubes Estimates of the severity of coronavirus disease 2019: a model-based analysis A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease Rates of Cases, Hospitalizations and Deaths by Race/Ethnicity Group COVID-19: They are based on the major observed disease complications that impact drug absorption, distribution, metabolism, and elimination. keywords: absorption; acute; administration; covid-19; disease; dosing; drug; hemodialysis; patients; therapies; treatment cache: cord-316029-z708c3ex.txt plain text: cord-316029-z708c3ex.txt item: #1977 of 2876 id: cord-316067-mlcczr8c author: Ng, Jia H. title: Outcomes of patients with end-stage kidney disease hospitalized with COVID-19 date: 2020-08-15 words: 4311 flesch: 43 summary: Impact of age, race and ethnicity on dialysis patient survival and kidney transplantation disparities Causes of death in dialysis patients: J o u r n a l P r e -p r o o f racial and gender differences Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis Association of inflammatory markers with the severity of COVID-19: This inherent survival advantage may partly explain our finding of improved hospital survival of Black ESKD patients with COVID-19. keywords: covid-19; death; dialysis; eskd; hospital; mortality; patients; risk cache: cord-316067-mlcczr8c.txt plain text: cord-316067-mlcczr8c.txt item: #1978 of 2876 id: cord-316083-f1h2j6jx author: Alamri, Ahmad title: None date: 2020-05-21 words: 1432 flesch: 47 summary: We think that a systematic (or focused) screening of health care workers might be helpful to provide evidence-based epidemiological data, and reduce the general anxiety cause by a probable underestimation of cases. The actual number of cases is unknown and is probably underestimated, since asymptomatic cases have been reported with unknown frequency [13] , and that mild infections could have passed unnoticed. keywords: cases; health; patients; sars cache: cord-316083-f1h2j6jx.txt plain text: cord-316083-f1h2j6jx.txt item: #1979 of 2876 id: cord-316095-jzyb4jn5 author: Falahchai, Mehran title: Dental care management during the COVID‐19 outbreak date: 2020-09-19 words: 5607 flesch: 46 summary: During the COVID-19 pandemic, digital dentistry can greatly help in emergency management of dental patients whose temporary restorations are lost. Person-to-person transmission is very common among the family members and also healthcare workers who are in direct contact with COVID-19 patients and carriers. keywords: care; coronavirus; covid-19; dental; emergency; infection; patients; procedures; room; transmission; treatment; use cache: cord-316095-jzyb4jn5.txt plain text: cord-316095-jzyb4jn5.txt item: #1980 of 2876 id: cord-316117-o29773cz author: Menzella, Francesco title: Pharmacologicaltreatment of COVID-19: lights and shadows date: 2020-05-19 words: 4471 flesch: 38 summary: Specifically, a cytokine profile resembling MAS has been noted in COVID-19 patients, with increased interleukin (IL)-1β, IL-2, IL-6, IL-17, IL-8, tumor necrosis factor, and C-C motif chemokine ligand 2. 12 Current recommendations for the treatment of COVID-19 severe cases consist of using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality. Fighting viruses with antibiotics: an overlooked path Teicoplanin potently blocks the cell entry of 2019-nCoV Coagulopathy and antiphospholipid antibodies in patients with Covid-19 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Renin-angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension Preliminary identification of potential vaccine targets for the COVID-19 coronavirus (SARS-CoV-2) based on SARS-CoV immunological studies A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease Lack of peripheral memory B cell responses in recovered patients with severe acute respiratory syndrome: a six-year follow-up study Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection A sequence homology and bioinformatic approach can predict candidate targets for immune responses to SARS-CoV-2 Johnson Announces a Lead Vaccine Candidate for COVID-19 Department of Health & Human Services; and Commitment to Supply One Billion Vaccines Worldwide for Emergency Pandemic Use Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice Optimization of the production process and characterization of the yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1), a SARS vaccine candidate Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. keywords: coronavirus; cov-2; covid-19; drugs; efficacy; infection; patients; pneumonia; remdesivir; sars; syndrome; treatment cache: cord-316117-o29773cz.txt plain text: cord-316117-o29773cz.txt item: #1981 of 2876 id: cord-316118-ph582weg author: Frajkova, Zofia title: Postintubation Dysphagia During COVID-19 Outbreak-Contemporary Review date: 2020-05-28 words: 5106 flesch: 36 summary: The aim of this review is to summarize available information on possible mechanisms of postintubation dysphagia in COVID-19 patients. Recommendations regarding the diagnosis and management of postintubation dysphagia in COVID-19 patients are described in this contemporary review. keywords: aspiration; covid-19; dysphagia; intubation; oral; patients; postintubation; risk; screening; swallowing cache: cord-316118-ph582weg.txt plain text: cord-316118-ph582weg.txt item: #1982 of 2876 id: cord-316135-kevyw19w author: Nikoupour, Hamed title: Pediatric liver transplantation and COVID-19: a case report date: 2020-10-06 words: 1662 flesch: 47 summary: For pediatric patients with organ transplantations, extreme caution should be taken, to limit and prevent their contact with COVID-19 during the outbreak, as these patients are highly susceptible to severe forms of the disease. [5] reported in-hospital infection rates in a large series of pediatric patients to be 9.4%, moreover infections constituted 35.2% of all causes of death in this population. keywords: covid-19; liver; patient; pediatric cache: cord-316135-kevyw19w.txt plain text: cord-316135-kevyw19w.txt item: #1983 of 2876 id: cord-316137-6zdxfv8v author: Wang, Yuanyuan title: Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching date: 2020-11-05 words: 4552 flesch: 49 summary: Of these, 22% of severe patients and up to 78% of critically ill patients had death as the outcome. The National Health Commission of the People's Republic of China (2020a, 2020b) recommended the traditional Chinese medicine (TCM), which has a long history in treating influenza-like diseases and proven to be effective in treating severe acute respiratory syndrome (SARS) epidemic in 2003 (Chen and Nakamura, 2004; Lau et al., 2005; Leung, 2007) , to be used jointly with modern treatment for COVID-19 patients. keywords: care; china; chm; clinical; covid-19; day; disease; granules; group; patients; study cache: cord-316137-6zdxfv8v.txt plain text: cord-316137-6zdxfv8v.txt item: #1984 of 2876 id: cord-316170-ihh0pxov author: Chang, De title: Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection date: 2020-05-01 words: 1295 flesch: 50 summary: Patients were discharged after their recovery and confirmation of virus-negative status by at least two consecutive real-time PCRs (3) . There was only one case of a false-negative result in our study: patient 6 had a negative test result followed by a positive detection and then two consecutive negative tests. keywords: patients; symptoms; virus cache: cord-316170-ihh0pxov.txt plain text: cord-316170-ihh0pxov.txt item: #1985 of 2876 id: cord-316306-vfez5k02 author: Bini, Stefano A. title: Digital Orthopaedics. A Glimpse into the Future in The Midst of a Pandemic date: 2020-04-22 words: 2609 flesch: 36 summary: The orthopaedic community has risen to the challenge of caring for patients sheltering 392 in place by exploring and adopting a set of digital health technologies that have extended the 393 community's ability to triage and deliver care in the most appropriate venue, whether that be at 394 home, the clinic or the hospital. The best results come from adaptation 402 rather than reinvention Impact of scribes on physician satisfaction, patient satisfaction, and 405 charting efficiency: a randomized controlled trial Healthcare ex Machina: Are conversational agents ready for 407 prime time in oncology Rehabilitation In-Home Therapy Compared with Traditional Care After Total Knee Arthroplasty: 411 VERITAS, a Randomized Controlled Trial Telehealth Care Navigation for Arthroplasty Patients: A Retrospective Case Series A fiasco in the making? keywords: adoption; care; covid-19; digital; health; orthopaedics; patients; technologies cache: cord-316306-vfez5k02.txt plain text: cord-316306-vfez5k02.txt item: #1986 of 2876 id: cord-316370-t802kjpk author: Szperka, Christina L. title: Migraine Care in the Era of COVID‐19: Clinical Pearls and Plea to Insurers date: 2020-04-03 words: 4043 flesch: 41 summary: A randomized clinical trial Eptinezumab for prevention of chronic migraine: A randomized phase 2b clinical trial Eptinezumab in episodic migraine: A randomized, double-blind, placebo-controlled study (PROMISE-1) Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): Randomised, placebo controlled, crossover study Prophylactic treatment of migraine with an angiotensin II receptor blocker: A randomized controlled trial ACE and ARB agents in the prophylactic therapy of migraine-how effective are they? Efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the preventative treatment of episodic migraine in adults Efficacy of lisinopril in migraine prophylaxis -An open label study HFSA/ACC/ AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19 Randomised clinical trial comparing melatonin 3 mg, amitriptyline 25 mg and placebo for migraine prevention Use of melatonin versus valproic acid in prophylaxis of migraine patients: A double-blind randomized clinical trial. Further, given that nearly 1/5 of households in the United States reported a layoff or reduction in work hours related to coronavirus by March 14, 2020, 3 it is imperative that insurance providers minimize or eliminate copays for migraine medications. keywords: acute; care; covid-19; days; headache; migraine; patients; treatment; trial cache: cord-316370-t802kjpk.txt plain text: cord-316370-t802kjpk.txt item: #1987 of 2876 id: cord-316376-76beuk0c author: Medeiros, Augusto Kreling title: Higher frequency of hepatic steatosis at CT among COVID-19-positive patients date: 2020-07-18 words: 4132 flesch: 36 summary: Major strengths include the fact that this is the first study to compare steatosis on CT between positive and negative COVID-19 patients; the sample size, which has allowed statistical power to identify the higher frequency of liver steatosis among SARS-CoV2 positive patients; finally, as CT studies were performed on the same scanner (to avoid exposure of patients without flu syndrome), with a variable protocol according to their body habitus, inter-scanner variability that could have affected measurements did not compromise the results, allowing uniformity. These findings are in accordance with other recent studies linking obesity and COVID-19 infection, as there is an intricate relationship between liver steatosis, metabolic syndrome and obesity. keywords: covid-19; disease; group; liver; obesity; patients; steatosis; study cache: cord-316376-76beuk0c.txt plain text: cord-316376-76beuk0c.txt item: #1988 of 2876 id: cord-316432-xemz7zn9 author: Talaie, Haleh title: Is there any potential management against COVID-19? A systematic review and meta-analysis date: 2020-08-18 words: 5097 flesch: 33 summary: National Institutes of Health Drug-eluting stents versus bare metal stents for saphenous vein graft revascularisation: a meta-analysis of randomised trials Immunosuppressive drugs to reduce the mortality rate in patients with moderate to severe paraquat poisoning: a meta-analysis Legionella prevalence and risk of legionellosis in Japanese households Quantifying heterogeneity in a metaanalysis Bioaccumulation of potentially toxic elements (PTEs) in muscleTilapiaspp fish: a systematic review, meta-analysis, and non-carcinogenic risk assessment Toxocara eggs in public places worldwide-a systematic review and meta-analysis The global seroprevalence of toxoplasma gondii in pigs: a systematic review and meta-analysis The global seroprevalence of toxoplasma DARU J Pharm Sci gondii among wild boars: a systematic review and meta-analysis Seroprevalence estimates for toxocariasis in people worldwide: A systematic review and meta-analysis Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Lopinavir-ritonavir versus hydroxychloroquine for viral clearance and clinical improvement in patients with mild to moderate coronavirus disease 2019 Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York state Full-length title: Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome Treatment Response to Hydroxychloroquine, Lopinavir/Ritonavir, and Antibiotics for Moderate COVID 19: A First Report Pharmacol Outcomes South Korea. medRxiv Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial Treatment of 5 critically ill patients with COVID-19 with convalescent plasma Treatment with convalescent plasma for COVID-19 patients in Wuhan Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma Mortality reduction in 46 severe Covid-19 patients treated with hyperimmune plasma. keywords: analysis; coronavirus; covid-19; meta; mortality; patients; plasma; review; studies; study; therapy; treatment cache: cord-316432-xemz7zn9.txt plain text: cord-316432-xemz7zn9.txt item: #1989 of 2876 id: cord-316522-fbw9x3ik author: Reiss, Allison B. title: A Telemedicine Approach to Covid-19 Assessment and Triage date: 2020-09-10 words: 3800 flesch: 47 summary: The most common laboratory abnormality in Covid-19 patients is lymphopenia, with decrease in lymphocyte count more profound in severe cases [60, 61] . The most common laboratory abnormality in Covid-19 patients is lymphopenia, with decrease in lymphocyte count more profound in severe cases [60, 61] . keywords: coronavirus; covid-19; disease; infection; patients; risk; screening; telemedicine; visit cache: cord-316522-fbw9x3ik.txt plain text: cord-316522-fbw9x3ik.txt item: #1990 of 2876 id: cord-316572-7ei96rrn author: Touska, P title: The role of transoral fine needle aspiration in expediting diagnosis and reducing risk in head and neck cancer patients in the coronavirus disease 2019 (COVID-19) era: a single-institution experience date: 2020-09-02 words: 3267 flesch: 33 summary: Transoral fine needle aspiration cytology offers a low-risk means of rapidly diagnosing patients with oral cavity or oropharyngeal lesions. Diagnostic outcomes were retrospectively evaluated for a series of patients undergoing transoral fine needle aspiration cytology of oral cavity and oropharyngeal lesions during the COVID-19 pandemic. keywords: covid-19; diagnosis; lesions; neck; needle; patients; transoral cache: cord-316572-7ei96rrn.txt plain text: cord-316572-7ei96rrn.txt item: #1991 of 2876 id: cord-316616-j82q99in author: Su, Yen-Bo title: Cardiovascular manifestation and treatment in COVID-19 date: 2020-05-19 words: 4455 flesch: 28 summary: In addition, 71% of COVID-19 patients who died fulfilled the International Society on Thrombosis and Haemostasis (ISTH) criteria for DIC, compared with only 0.6% among survivors. 34 Gilead has initiated several trials in United States and China to evaluate the effect of remdesivir in COVID-19 patients with different disease severity (https://www.gilead.com/purpose/ advancing-global-health/covid-19/remdesivir-clinical-trials). keywords: cardiac; coronavirus; covid-19; disease; infection; injury; levels; mortality; patients; pneumonia; sars; treatment cache: cord-316616-j82q99in.txt plain text: cord-316616-j82q99in.txt item: #1992 of 2876 id: cord-316647-jj8anf5g author: Shang, You title: Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China date: 2020-06-06 words: 13606 flesch: 35 summary: However, considering the suggestion that restrictive fluid volume management strategy should be adopted for COVID-19 patients complicated by ARDS based on the premise of sufficient tissue perfusion, we suggest CRRT initiation in severe patients within 24 h when they show rank 2 AKI under KDIGO criteria or accompanied with cytokine storm syndrome. There are still no targeted therapies for COVID-19 patients. keywords: acute; aki; ards; care; coronavirus; covid-19; covid-19 patients; disease; expert; grade; infection; lung; mortality; patients; rationale; recommendation; risk; sedation; study; syndrome; therapy; treatment; use; ventilation cache: cord-316647-jj8anf5g.txt plain text: cord-316647-jj8anf5g.txt item: #1993 of 2876 id: cord-316666-qif1k62t author: Ghati, Nirmal title: Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial date: 2020-10-30 words: 4405 flesch: 39 summary: Patients with early discharge (due to clinical improvement and patient's preference for home isolation) will be followed up by alternate day telephonic contact till 10 th day of drug regimen. The safety of these drugs in COVID-19 patients will also be evaluated. keywords: aspirin; atorvastatin; covid-19; days; disease; group; infection; patients; statins; study; therapy; trial cache: cord-316666-qif1k62t.txt plain text: cord-316666-qif1k62t.txt item: #1994 of 2876 id: cord-316673-ffkh13xm author: Andina, David title: Chilblains in children in the setting of COVID‐19 pandemic date: 2020-05-22 words: 1365 flesch: 40 summary: Severe acral ischemic lesions due to thrombosis have been observed in COVID-19 patients, usually admitted to intensive care units with very severe disease. In other instances, patients showed swollen toes with dusky, violaceous discoloration. keywords: cases; chilblains; children; lesions; patients cache: cord-316673-ffkh13xm.txt plain text: cord-316673-ffkh13xm.txt item: #1995 of 2876 id: cord-316728-vyfkmniu author: Benyounes, Nadia title: Echocardiography in Confirmed and Highly Suspected Symptomatic COVID-19 Patients and Its Impact on Treatment Change date: 2020-09-16 words: 3456 flesch: 43 summary: To explore echocardiography's impact on the management of COVID-19 patients. is is why we had to perform TTEs/TEEs on COVID-19 patients admitted to our institution. keywords: change; covid-19; echocardiography; patients; study; treatment; troponin cache: cord-316728-vyfkmniu.txt plain text: cord-316728-vyfkmniu.txt item: #1996 of 2876 id: cord-316743-q6gbxghx author: Madhu, S. V. title: Post COVID-19 diabetes care—lessons and challenges date: 2020-06-04 words: 1692 flesch: 37 summary: DPP4 inhibitors are another class of antidiabetic agents which are believed to have a potential to reduce the incidence and severity of complications associated with COVID-19 infections particularly in diabetic patients. A high degree of alertness with frequent self-monitoring of blood glucose levels is certainly advisable in known diabetic patients particularly insulin users to reduce the risk of being affected with COVID-19 infection and avoid any undesirable consequence should they get infected. keywords: covid-19; diabetes; infections; patients cache: cord-316743-q6gbxghx.txt plain text: cord-316743-q6gbxghx.txt item: #1997 of 2876 id: cord-316764-ps89rxuy author: Liu, Zheng title: At the center of the COVID‐19 pandemic: Lessons learned for otolaryngology‐head and neck surgery in China date: 2020-05-12 words: 1777 flesch: 37 summary: A fever clinic has been set up to identify patients with COVID-19 and to separate them from COVID-19 negative patients with fever and/or respiratory symptoms similar to those found in COVID-19. Patients who have remained in Beijing for over 14 days are permitted to enter, and patients are scheduled for surgical procedures only when the test for COVID-19 is negative. keywords: beijing; covid-19; hospital; medical; patients; tracheostomy cache: cord-316764-ps89rxuy.txt plain text: cord-316764-ps89rxuy.txt item: #1998 of 2876 id: cord-316835-qf0c91vr author: McLeod, Jacob M. title: Nontraumatic Osteonecrosis of the Distal Tibia: A Case Presentation and Review of the Literature date: 2016-08-18 words: 4422 flesch: 44 summary: Just as with the hip, initial surgical correction of ankle ON is aimed at sparing the joint, at least during the early stages of the disease. To our knowledge, no case reports have illustrated the use of implantable total ankle arthroplasty to treat ankle ON. keywords: ankle; bone; case; head; hip; osteonecrosis; patient; review; tibia; treatment cache: cord-316835-qf0c91vr.txt plain text: cord-316835-qf0c91vr.txt item: #1999 of 2876 id: cord-316845-k9zvsfvj author: Robertson, Mary M. title: Gilles de la Tourette Syndrome: advice in the times of COVID-19 date: 2020-04-28 words: 3764 flesch: 48 summary: Finally, it has been shown that elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict progression in COVID-19 patients (Zheng et al., 2020b). Coronavirus particles are surrounded by a fatty outer layer called an envelope and usually are spherical when visualised under an electron microscope, with a corona of club-shaped spikes on their surface (Wu et al., 2020). keywords: anxiety; covid-19; gts; pandemic; patients; sars; symptoms cache: cord-316845-k9zvsfvj.txt plain text: cord-316845-k9zvsfvj.txt item: #2000 of 2876 id: cord-316873-2gwl9m94 author: Crowley, Jerome title: Adult Extracorporeal Membrane Oxygenation Patient Selection During Coronavirus Disease 2019: The Value of a Review Panel During Coronavirus Disease 2019 date: 2020-06-23 words: 318 flesch: 31 summary: Recommendations to improve survival Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) Survival rate in acute kidney injury superimposed COVID-19 patients: a systematic review and meta-analysis Copyright © 2020 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. This is critically important for patient selection but also device selection with the ability to offer cardiac, respiratory, and renal support through hybrid ECMO configurations. keywords: disease; patient cache: cord-316873-2gwl9m94.txt plain text: cord-316873-2gwl9m94.txt item: #2001 of 2876 id: cord-316938-64jxtg9y author: Blasi, Annabel title: In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation date: 2020-08-06 words: 3076 flesch: 36 summary: The high thrombosis risk in COVID-19 patients has been linked to a hypercoagulable state that has not been well-defined. Test results were compared between COVID-19 patients and healthy controls, and between patients admitted to the ICU and the ward, using the Mann-Whitney U test. keywords: article; coagulation; covid-19; icu; levels; patients; plasma; thrombin cache: cord-316938-64jxtg9y.txt plain text: cord-316938-64jxtg9y.txt item: #2002 of 2876 id: cord-316987-3nhqx2qn author: London, Viktoriya title: Caring for Pregnant Patients with COVID-19: Practical Tips Getting from Policy to Practice date: 2020-05-07 words: 1826 flesch: 45 summary: Two aspects of outpatient care needed to be considered: (1) how to change practice to minimize viral exposure of healthy patients and providers, and (2) how to utilize outpatient resources to off-load some of the inpatient burden of taking care of COVID-19 patients. Intravenous (IV) extension tubing should be utilized to allow the IV pumps to be placed outside the rooms, decreasing nurses' exposure to COVID-19 patients. keywords: care; coronavirus; covid-19; labor; patients cache: cord-316987-3nhqx2qn.txt plain text: cord-316987-3nhqx2qn.txt item: #2003 of 2876 id: cord-317028-f3bpwm5j author: Olmsted, Russell N. title: Prevention by Design: Construction and Renovation of Health Care Facilities for Patient Safety and Infection Prevention date: 2016-08-09 words: 5191 flesch: 38 summary: FGI also needs to facilitate development of best practice and alternative concept guidance for health care design. Incorporation of health care facility guidelines; for example, FGI 3. keywords: care; construction; control; design; facilities; guidelines; health; infection; patient; prevention; risk; rooms; surfaces; water cache: cord-317028-f3bpwm5j.txt plain text: cord-317028-f3bpwm5j.txt item: #2004 of 2876 id: cord-317075-zegearxa author: Madenidou, Anastasia-Vasiliki title: Real-life experience of tocilizumab use in COVID-19 patients date: 2020-06-17 words: 885 flesch: 41 summary: Tocilizumab treatment in COVID-19: a single center experience COVID-19 in solid organ transplant recipients: initial report from the US epicenter Interleukin-6 blockade for severe COVID-19 Effective treatment of severe COVID-19 patients with tocilizumab Offlabel use of tocilizumab in patients with SARS-CoV-2 infection Letter to the Editor: acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab Rapid and severe Covid-19 pneumonia with severe acute chest syndrome in a sickle cell patient successfully treated with tocilizumab A case of novel coronavirus disease 19 in a chronic hemodialysis patient presenting with gastroenteritis and developing severe pulmonary disease Covid-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine Case study: a patient with asthma, Covid-19 pneumonia and cytokine release syndrome treated with corticosteroids and tocilizumab First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report A.-V.M. would like to thank Dr Jessica Manson, Rheumatology consultant at University College London Hospital, who instilled in her the interest in hyperinflammation syndromes. key: cord-317075-zegearxa authors: Madenidou, Anastasia-Vasiliki; Bukhari, Marwan title: Real-life experience of tocilizumab use in COVID-19 patients date: 2020-06-17 journal: Rheumatology (Oxford) DOI: 10.1093/rheumatology/keaa325 sha: doc_id: 317075 cord_uid: zegearxa nan the majority of patients (42.4%) had one dose of 8 mg/ kg or 400 mg intravenously. keywords: covid-19; patients; tocilizumab cache: cord-317075-zegearxa.txt plain text: cord-317075-zegearxa.txt item: #2005 of 2876 id: cord-317085-qc8bfb9g author: Zhang, Nan title: Risk Factors for Poor Outcomes of Diabetes Patients With COVID-19: A Single-Center, Retrospective Study in Early Outbreak in China date: 2020-09-24 words: 4757 flesch: 49 summary: Furthermore, the value of hs-CRP, ESR and PCT in the severe patients were significantly higher than those value in non-severe patients (p < 0.05). A retrospective cohort study was undertaken on diabetic patients with COVID-19 infection in Central Hospital of Wuhan, a designated medical institution in SARS-CoV-2 infection. keywords: clinical; covid-19; diabetes; events; infection; iqr; patients; sars; study cache: cord-317085-qc8bfb9g.txt plain text: cord-317085-qc8bfb9g.txt item: #2006 of 2876 id: cord-317151-cxx5pcln author: Papa, Alfredo title: Covid-19 and the management of patients with inflammatory bowel disease: a practical decalogue for the post-pandemic phase date: 2020-10-24 words: 5035 flesch: 37 summary: Coronavirus situation report Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms Evidence for gastrointestinal infection of SARS-CoV-2 Challenges in the care of IBD patients during the CoVID-19 pandemic: report from a Red Zone area in Northern Italy Serious infection and mortality in patients with Crohn's disease: more than 5 years of follow-up in the TREAT registry Anti-TNFalpha agents in inflammatory bowel disease and course of COVID-19 Impact of COVID-19 pandemic on the daily management of biotechnological therapy in inflammatory bowel disease patients: reorganisational response in a high-volume Italian inflammatory bowel disease centre European Crohn's and Colitis Organization. A retrospective study from the United States including a large cohort of IBD patients reported that the incidence rate of COVID-19 per 1000 IBD patients was of 0.61 in patients treated with anti-TNF-α and 1 in those not in treatment with anti-TNF-α (p = 0.618). keywords: bowel; covid-19; disease; face; ibd; pandemic; patients; sars; surgery; therapy; use cache: cord-317151-cxx5pcln.txt plain text: cord-317151-cxx5pcln.txt item: #2007 of 2876 id: cord-317242-e7000i2u author: Gandhi, Darshan title: Review of X-ray and computed tomography scan findings with a promising role of point of care ultrasound in COVID-19 pandemic date: 2020-09-28 words: 2932 flesch: 47 summary: Volume rendered chest CT imaging has been successfully utilized in COVID-19 patients to delineate disease, demonstrate September 28, 2020 Volume 12 Issue 9 newly developed lesions and ascertain their distribution The full spectrum of chest CT findings observed in COVID-19 disease includes ground-glass opacification (pure, with crazy-paving, or with accompanying consolidation), pure consolidation, air bronchograms, pleural effusions, lymphadenopathy (Figures 3, 4 and 5) keywords: chest; covid-19; disease; findings; patients cache: cord-317242-e7000i2u.txt plain text: cord-317242-e7000i2u.txt item: #2008 of 2876 id: cord-317265-n6x0r58i author: Singh, Varsha title: Can Vitamins, as Epigenetic Modifiers, Enhance Immunity in COVID-19 Patients with Non-communicable Disease? date: 2020-07-13 words: 3942 flesch: 26 summary: The purpose of this review is to provide evidence to consider vitamins as epigenetic modifiers to enhance immunity and reduce inflammatory response in COVID-19 patients with non-communicable diseases. It is noteworthy that this individualized approach has a potential of obtaining positive results for COVID-19 patients, if individuals are thoroughly tested and treated according to their unique metabolic function. keywords: cancer; covid-19; disease; factors; ncds; non; patients; response; risk; system; vitamin cache: cord-317265-n6x0r58i.txt plain text: cord-317265-n6x0r58i.txt item: #2009 of 2876 id: cord-317344-wznzmssz author: Iannitti, T. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 words: 24555 flesch: 38 summary: The study showed the following results: one hundred subjects completed the study (48 in the probiotic combination group and 52 in the placebo group); the probiotic combination was not superior to the placebo in relieving symptoms of IBS (42.6% versus 42.3% improvement); the decrease of abdominal pain between the first and the fourth week of treatment was significantly higher in probiotic treated patients (À41.9 versus À24.2%, P ¼ 0.048). Sixty six patients (88%) were symptom-free after the 24th month of treatment: 11 of group M1, 8 of group M2, 15 of group LM1, 12 of group LM2 and 20 in group L. Four patients (5.33%) suspended the treatment during the follow-up: all experienced recurrence of symptoms (100%), and two of them developed diverticulitis (50%). keywords: activity; administration; authors; bacteria; bowel; cells; colon; daily; day; days; diarrhea; disease; effect; et al; group; ibs; lactobacillus; microbiota; p ¼; pain; patients; placebo; placebo group; probiotic; pylori; rhamnosus; strains; study; symptoms; therapy; treatment; trial; use; weeks cache: cord-317344-wznzmssz.txt plain text: cord-317344-wznzmssz.txt item: #2010 of 2876 id: cord-317468-pnxni1x5 author: Louie, Philip K. title: Early Peri-operative Outcomes Were Unchanged in Patients Undergoing Spine Surgery During the COVID-19 Pandemic in New York City date: 2020-09-15 words: 3491 flesch: 33 summary: Recognizing not only that the pandemic would likely preclude elective surgery for several months, but also that delay of surgical treatment for several months could result in permanent disability or neurological impairment in a subset of spine surgery patients, the following essential surgery criteria were determined: progressive weakness on exam or weakness with active denervation on electromyography, myelopathy with cord at risk, fracture or trauma with spinal instability, or cauda equina syndrome ( Table 1 ). Furthermore, a subgroup comparison was performed among pandemic study patients who underwent surgery before versus after the suspension of elective procedures. keywords: cov-2; pandemic; patients; post; sars; study; surgery cache: cord-317468-pnxni1x5.txt plain text: cord-317468-pnxni1x5.txt item: #2011 of 2876 id: cord-317535-zep5axfo author: Azpiazu Landa, N. title: Ischemic-hemorrhagic stroke in patients with Covid-19 date: 2020-11-07 words: 1967 flesch: 36 summary: COVID-19 and the Heart Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Anestesiología y los anestesiólogos en la COVID-19 Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid -19 First case of 2019 novel coronavirus disease with Encephalitis Coexistence of Covid -19 and Acute Ischemic Stroke Report of Four Cases key: cord-317535-zep5axfo authors: Azpiazu Landa, N.; Velasco Oficialdegui, C.; Intxaurraga Fernández, K.; Gonzalez Larrabe, I.; Riaño Onaindia, S.; Telletxea Benguria, S. title: Ischemic-hemorrhagic stroke in patients with Covid-19 date: 2020-11-07 journal: nan DOI: 10.1016/j.redare.2020.08.001 sha: doc_id: 317535 cord_uid: zep5axfo Coronavirus associated severe acute respiratory syndrome (SARS-CoV-2) causes a worldwide syndrome called Covid-19 that has caused 5,940,441 infections and 362,813 deaths until May 2020. keywords: covid-19; days; disease; infection; patients; sars cache: cord-317535-zep5axfo.txt plain text: cord-317535-zep5axfo.txt item: #2012 of 2876 id: cord-317566-6ch6na31 author: Epstein, Robert S. title: Patient Burden and Real-World Management of Chemotherapy-Induced Myelosuppression: Results from an Online Survey of Patients with Solid Tumors date: 2020-07-08 words: 4854 flesch: 37 summary: Usefulness of the perform questionnaire to measure fatigue in cancer patients with anemia: a prospective, observational study Experiencing neutropenia: quality of life interviews with adult cancer patients Patient and health care provider perceptions of cancerrelated fatigue and pain Patient perceptions of symptoms and concerns during cancer chemotherapy: 'affects my family' is the most important Changing patient perceptions of the side effects of cancer chemotherapy The social and emotional toll of chemotherapy-patients' perspectives The impact of medical visits for chemotherapy-induced anemia and neutropenia on the patient and caregiver: a national survey Transfusions and patient burden in chemotherapyinduced anaemia in France A retrospective study to evaluate the time burden associated with outpatient red blood transfusions indicated for anemia due to concomitantly administered chemotherapy in cancer patients Real-world burden of myelosuppression in patients with small cell lung cancer (SCLC): retrospective, longitudinal data analysis Use and patterns of supportive care among patients receiving myelosuppressive chemotherapy for breast cancer, colorectal cancer, lung cancer, or non-Hodgkin's lymphoma in US clinical practice Patterns of chemotherapy-associated toxicity and supportive care in US oncology practice: a nationwide prospective cohort study Current burden of chemotherapy induced anemia and patterns of erythropoiesis-stimulating agents utilization Nordyke RJ. Use of erythropoiesis-stimulating agents among chemotherapy patients with hemoglobin Adv Ther exceeding 12 grams per deciliter Transfusion practice patterns in patients with anemia receiving myelosuppressive chemotherapy for nonmyeloid cancer: results from a prospective observational study Guidelines for the use of platelet transfusions Chemotherapy dose intensity and overall survival among patients with advanced breast or ovarian cancer Role of nurses in the assessment and management of chemotherapy-related side effects in cancer patients The patient-healthcare professional relationship and communication in the oncology outpatient setting: a systematic review Patients' perceptions of physician-patient discussions and adverse events with cancer therapy Covid-19: keywords: cancer; chemotherapy; cim; effects; myelosuppression; participants; patients; survey; treatment cache: cord-317566-6ch6na31.txt plain text: cord-317566-6ch6na31.txt item: #2013 of 2876 id: cord-317575-srg9cyqp author: Chien, Chen‐Yu title: Proactive measures for the pandemic COVID‐19 infection in outpatient clinics of Otolaryngology Department date: 2020-06-03 words: 459 flesch: 44 summary: However, patients suspected of having foreign body impaction or head and neck cancers still require fiberscope examination. A study noted that for 83% of patients in Singapore, viral shedding from the nasopharynx continued for 7 days or longer. keywords: nose; patients cache: cord-317575-srg9cyqp.txt plain text: cord-317575-srg9cyqp.txt item: #2014 of 2876 id: cord-317604-j8b64a1a author: Sahay, Sandeep title: Management of hospitalized patients with pulmonary arterial hypertension and COVID-19 infection date: 2020-06-15 words: 2064 flesch: 27 summary: New onset fever, cough or myalgias might suggest COVID-19 infection; however, PAH patients receiving intravenous continuous prostacyclin infusions can present with high grade fever due to catheter infection. There are some anecdotal data suggesting that ERA can block angiotensin II receptors, which are needed for viral entry into the cells, thus offering some potential protection in PAH patients. keywords: covid-19; fees; hypertension; infection; pah; patients; risk cache: cord-317604-j8b64a1a.txt plain text: cord-317604-j8b64a1a.txt item: #2015 of 2876 id: cord-317689-gp4x54pe author: Galanopoulou, Aristea S. title: EEG findings in acutely ill patients investigated for SARS‐CoV‐2/COVID‐19: A small case series preliminary report date: 2020-05-17 words: 4721 flesch: 41 summary: A significant difference was seen in prevalence of positive blood cultures among COVID-19 negative patients (4/6, 66.7% vs COVID-19 positive (0/21, 0%) (P = .0009). We attempted a comparison with COVID-19 negative patients who would have been more likely to have similar clinical presentation and EEG indications as the COVID-19-positive patients. keywords: covid-19; eeg; eegs; events; negative; patients; positive; seizures; study cache: cord-317689-gp4x54pe.txt plain text: cord-317689-gp4x54pe.txt item: #2016 of 2876 id: cord-317809-umb8j63t author: Salari, Abolfazl title: COVID-19 pandemic & head and neck cancer patients management: The role of virtual multidisciplinary team meetings date: 2020-04-08 words: 858 flesch: 31 summary: Dedicate most of the health system facilities to this disease, whether in terms of physical facilities, finances, and equipment or in terms of staffing for COVID-19 patients, limits the services available to other patients, especially cancer patients. On the other hand, cancer patients who require surgery may be at risk of coronavirus infection due to hospitalization, infection by the ventilator during anesthesia, and ICU infection. keywords: patients; treatment cache: cord-317809-umb8j63t.txt plain text: cord-317809-umb8j63t.txt item: #2017 of 2876 id: cord-317811-mxsujb5u author: Migliaccio, Raffaella title: Dementia and COVID-19 Lockdown: More Than a Double Blow for Patients and Caregivers date: 2020-07-06 words: 2661 flesch: 52 summary: This huge modification in everyday life, associated with the inability of dementia patients to manage the present situation, makes these current times hugely demanding for patients and their families. This could involve reducing the number of patients per care unit and the number of healthcare professionals per patient, as well as the implementation of technology to maintain contact with the outside world. keywords: caregivers; covid-19; dementia; health; pandemic; patients cache: cord-317811-mxsujb5u.txt plain text: cord-317811-mxsujb5u.txt item: #2018 of 2876 id: cord-317918-pl625ela author: Ripa, Marco title: Secondary Infections in Patients Hospitalized with COVID-19: Incidence and Predictive Factors date: 2020-10-24 words: 910 flesch: 34 summary: Aim of our study was to describe the incidence and predictive factors of secondary infections in patients with COVID-19. Patients hospitalized with COVID-19 had a high incidence of secondary infections. keywords: covid-19; infections; patients cache: cord-317918-pl625ela.txt plain text: cord-317918-pl625ela.txt item: #2019 of 2876 id: cord-317932-5sqj2klm author: Stevens, Jacob S. title: Dashboards to facilitate nephrology disaster planning in the COVID-19 era date: 2020-07-03 words: 1904 flesch: 42 summary: The high incidence and mortality among patients with AKI requiring RRT, coupled with the expansion of non-traditional ICU spaces, created substantial turnover and movement making it challenging to track patient volumes. 1 Resource planning required the ability to track patient censuses in real time to ensure patients were evenly distributed. keywords: crrt; number; patients; sharing; therapy cache: cord-317932-5sqj2klm.txt plain text: cord-317932-5sqj2klm.txt item: #2020 of 2876 id: cord-317952-4oa9hfb4 author: Bourgonje, Arno R. title: Angiotensin‐converting enzyme‐2 (ACE2), SARS‐CoV‐2 and pathophysiology of coronavirus disease 2019 (COVID‐19) date: 2020-05-17 words: 12115 flesch: 33 summary: Safety concerns of clinical images and skin biopsies Urticarial eruption in COVID-19 infection A case of COVID-19 pneumonia in a young male with full body rash as a presenting symptom Reply to COVID-19 can present with a rash and be mistaken for Dengue: Petechial rash in a patient with COVID-19 infection COVID-19 can present with a rash and be mistaken for Dengue Immune thrombocytopenic purpura in a patient with Covid-19 A distinctive skin rash associated with Coronavirus Disease Cutaneous manifestations in COVID-19: a first perspective Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study A case report of neonatal COVID-19 infection in China Novel coronavirus infection and pregnancy Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China Vertical transmission of coronavirus disease 2019 (COVID-19) from infected pregnant mothers to neonates: Possible explanations of male predominance among COVID-19 patients may be differences in exposure, smoking behaviour, other lifestyle factors, differences in chromosomal ACE2 expression, ACE2 expression in testicular tissue, sex hormone-driven immune system regulation, or gender differences in RAAS regulation [37, [42] keywords: ace2; acute; angiotensin; article; cells; clinical; copyright; coronavirus; cov-2; covid-19; disease; expression; human; immune; infection; injury; patients; potential; rights; role; sars; study; treatment cache: cord-317952-4oa9hfb4.txt plain text: cord-317952-4oa9hfb4.txt item: #2021 of 2876 id: cord-317966-ut6tzc8s author: Kocak, Burak title: A Case Report of Oligosymptomatic Kidney Transplant Patients with COVID-19: Do They Pose a Risk to Other Recipients? date: 2020-05-15 words: 2114 flesch: 42 summary: Thus, kidney transplant patients who are on steroids and other immunosuppressive drugs may exhibit unusual clinical courses resulting from coronavirus infection. It is a well-known entity that viral infections may cause atypical symptoms and signs in transplant patients due to the chronic immunosuppression. keywords: coronavirus; covid-19; disease; home; patients; transplant cache: cord-317966-ut6tzc8s.txt plain text: cord-317966-ut6tzc8s.txt item: #2022 of 2876 id: cord-318021-4qrf5m8s author: Wolfensberger, A. title: Development and validation of a semi-automated surveillance system—lowering the fruit for non-ventilator-associated hospital-acquired pneumonia (nvHAP) prevention() date: 2019-03-25 words: 3616 flesch: 37 summary: This would translate to a calculated workload for nvHAP surveillance in our 950-bed tertiary care centre of approximately 40 min per workday when using the semiautomatic surveillance system. This approach significantly reduces manual surveillance workload, thus making continuous nvHAP surveillance feasible as a pivotal element for successful prevention efforts. keywords: hospital; nvhap; patients; pneumonia; prevention; risk; surveillance; system cache: cord-318021-4qrf5m8s.txt plain text: cord-318021-4qrf5m8s.txt item: #2023 of 2876 id: cord-318063-bainw3d6 author: Haque, Mainul title: Health care-associated infections – an overview date: 2018-11-15 words: 8259 flesch: 37 summary: in Intensive Care Unit of a Tertiary Care Hospital Surveillance and Prevention of healthcare associated infections Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections The clinical and economic consequences of nosocomial central venous catheter-related infection: are antimicrobial catheters useful? Department of Health & Human Services Central line-associated blood stream infections: characteristics and risk factors for mortality over a 5.5-year period Central line-associated bloodstream infections among critically-ill patients in the era of bundle care Central line-associated bloodstream infection in hospitalized children with peripherally inserted central venous catheters: extending risk analyses outside the intensive care unit Surgical Site Infections Centers for Disease Control and Prevention. Reduction in the Prevalence of Healthcare-Associated Infections in U. S. Acute Care Hospitals Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey Burden of Six Healthcare-Associated Infections on European Population Health: Estimating Incidence-Based Disability-Adjusted Life Years through a Population Prevalence-Based Modelling Study Prevalence, incidence burden, and clinical impact of healthcare-associated infections and antimicrobial resistance: a national prevalent cohort study in acute care hospitals in Greece The Burden of Healthcare-Associated Infections in Southeast Asia: A Systematic Literature Review and Meta-analysis Point prevalence and risk factors of hospital acquired infections in a cluster of university-affiliated hospitals in Shiraz, Iran Investigating potential sources of transmission of healthcare-associated infections in a regional hospital Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America National Healthcare Safety Network (NHSN) Team and Participating NHSN Facilities. keywords: care; catheter; control; hand; hcais; health; healthcare; hospital; hygiene; infections; patients; pneumonia; prevention; resistance; ssis; study; surgery; surgical cache: cord-318063-bainw3d6.txt plain text: cord-318063-bainw3d6.txt item: #2024 of 2876 id: cord-318094-losjbgn6 author: Alan, Nima title: Inter-facility transfer of patients with traumatic intracranial hemorrhage and GCS 14–15: The pilot study of a screening protocol by neurosurgeon to avoid unnecessary transfers date: 2020-10-15 words: 3539 flesch: 47 summary: Interhospital transfer of neurosurgical patients: implications of timing on hospital course and clinical outcomes Comparison of management outcome of primary and secondary referred patients with traumatic extradural haematoma in a neurosurgical unit Interhospital transfer of neurosurgical patients to a high-volume tertiary care center: opportunities for improvement Interfacility neurosurgical transfers: an analysis of nontraumatic inpatient and emergency department transfers with implications for improvements in care identification and cost of potentially avoidable transfers to a tertiary care neurosurgery service: A pilot study Interhospital transfer of pediatric neurosurgical patients Recovery after mild traumatic brain injury in patients presenting to US Level I trauma centers: A transforming research and clinical knowledge in traumatic brain injury (TRACK-TBI) Study Redefining Mild Traumatic Brain Injury (mTBI) delineates cost effective triage Which transfers can we avoid: Multi-state analysis of factors associated with discharge home without procedure after ED to ED transfer for traumatic injury The pilot study of a screening protocol by neurosurgeon to avoid unnecessary transfers date: 2020-10-15 journal: J Clin Neurosci DOI: 10.1016/j.jocn.2020.09.050 sha: doc_id: 318094 cord_uid: losjbgn6 We sought to evaluate feasibility and cost-reduction potential of a pilot screening program involving neurosurgeon tele-consultation for inter-facility transfer decisions in TBI patients with GCS 14–15 and abnormal CT head at a community hospital. keywords: care; gcs; patients; study; tbi; transfer; trauma cache: cord-318094-losjbgn6.txt plain text: cord-318094-losjbgn6.txt item: #2025 of 2876 id: cord-318167-b25g6zkp author: Einollahi, Behzad title: A patient affected by critical COVID-19 pneumonia, successfully treated with convalescent plasma date: 2020-11-05 words: 1573 flesch: 36 summary: Prolonged viral shedding in a lymphoma patient with COVID-19 infection receiving convalescent plasma Convalescent (immune) plasma treatment in a myelodysplastic COVID-19 patient with disseminated tuberculosis Convalescent plasma: new evidence for an old therapeutic tool? Potential interventions for novel coronavirus in China: a systematic review Hypothesis to explain the severe form of COVID-19 in Northern Italy Use of convalescent plasma therapy in SARS patients in Hong Kong Retrospective comparison of convalescent plasma with continuing highdose methylprednisolone treatment in SARS patients Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol Effectiveness of convalescent plasma therapy in severe COVID-19 patients Convalescent plasma as a potential therapy for COVID-19 Treatment of 5 critically ill patients with COVID-19 with convalescent plasma Low Dose Radiation Therapy and Convalescent Plasma: How a Hybrid Method May Maximize Benefits for COVID-19 Patients Treatment with convalescent plasma for COVID-19 patients in Wuhan Successful treatment with plasma exchange followed by intravenous immunoglobulin in a critically ill patient with COVID-19 Therapeutic plasma exchange in adults with severe COVID-19 infection Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study Current studies of convalescent plasma therapy for COVID-19 may underestimate risk of antibody-dependent enhancement Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease COVID-19 convalescent plasma transfusion Thanks to guidance and advice from Clinical Research Development Unit of Baqiyatallah Hospital J o u r n a l P r e -p r o o f All authors contributed equally to the drafting ,designing and writing of the manuscript and provided critical revision. As the primary immune response arises after 10-14 days since viral infection, CP is more beneficial if administered as soon as possible in COVID-19 patients affected by ARDS and multi-organ disease syndrome, not later than 14 days since symptoms onset [15, 19, 20] . keywords: convalescent; covid-19; patient; plasma; therapy cache: cord-318167-b25g6zkp.txt plain text: cord-318167-b25g6zkp.txt item: #2026 of 2876 id: cord-318229-29cgwivt author: Baier, Claas title: Molecular characteristics and successful management of a respiratory syncytial virus outbreak among pediatric patients with hemato-oncological disease date: 2018-02-13 words: 5700 flesch: 43 summary: We therefore focused on patient to patient transmission early during the outbreak by strict isolation precautions for RSV infected patients and contacts. Looking exclusively at the molecular analysis, it is not possible to disclose the exact transmission pathway of RSV A. RSV A might have been introduced to the ward by an infected patient (index patient) on the ward (maybe case 1) and was then successively transmitted from patient to patient. keywords: case; infection; outbreak; patients; pediatric; rsv; syncytial; transmission; virus; ward cache: cord-318229-29cgwivt.txt plain text: cord-318229-29cgwivt.txt item: #2027 of 2876 id: cord-318262-w8oixzdg author: Chevance, A title: Ensuring mental health care during the SARS-CoV-2 epidemic in France: a narrative review date: 2020-04-22 words: 6753 flesch: 33 summary: To date, there is no structured data available on the epidemiology, clinical presentation and prognosis of psychiatric patients with COVID-19. This organization remains tenable because for the moment Ensuring the follow-up of psychiatric patients in a forced ambulatory situation. keywords: care; confinement; context; covid-19; disorders; epidemic; health; hospital; measures; medical; patients; people; population; psychiatric; risk cache: cord-318262-w8oixzdg.txt plain text: cord-318262-w8oixzdg.txt item: #2028 of 2876 id: cord-318282-ocgfgx9r author: Boyce, John M title: Meticillin-resistant Staphylococcus aureus date: 2005-10-31 words: 8590 flesch: 41 summary: Despite the absence of extensive data, reports of recent percentages of up to 70% of nosocomial MRSA infections confirm the urgent need for an effective antimicrobial usage policy for our country. The main principles are promotion of hand disinfection, identification of MRSA risk patients (carriers and contacts of known MRSA cases), rapid microbiological identification of MRSA, contact isolation of MRSA cases, and treatment of MRSA infections. keywords: aureus; care; community; control; health; hospital; infections; methicillin; mrsa; patients; resistance; screening; staphylococcus; strains; surveillance; vancomycin cache: cord-318282-ocgfgx9r.txt plain text: cord-318282-ocgfgx9r.txt item: #2029 of 2876 id: cord-318311-aakpbbvl author: Du, Na title: The experience of prevention measures taken by the psychiatric hospital during the emergence of asymptomatic patients with COVID-19 date: 2020-05-30 words: 1150 flesch: 47 summary: Due to the high infectivity of the COVID-19, without proper countermeasures, any input of infected patients would contaminate the entire ward. Thus, how to do an excellent job in epidemic prevention in psychiatric hospitals became a big challenge. keywords: hospital; patient; ward cache: cord-318311-aakpbbvl.txt plain text: cord-318311-aakpbbvl.txt item: #2030 of 2876 id: cord-318312-v1c3qm7h author: Fischer, Quentin title: Case report of anterior ST-elevation myocardial infarction in a patient with coronavirus disease-2019 date: 2020-05-19 words: 1645 flesch: 39 summary: While the general management of ACS has been well-defined in international guidelines, reports of ACS in COVID-19 patients are scarce, and there is no clear recommendation as regard to optimal treatment in such patients. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic COVID-19 and the cardiovascular system Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People's Hospital Case report of anterior STEMI in a patient with COVID-19 keywords: covid-19; elevation; infarction; patient cache: cord-318312-v1c3qm7h.txt plain text: cord-318312-v1c3qm7h.txt item: #2031 of 2876 id: cord-318326-q9fnbg8n author: Cacciapuoti, Sara title: Immunocytometric analysis of COVID patients: A contribution to personalized therapy? date: 2020-08-29 words: 3566 flesch: 42 summary: Such reduction involves B and T lymphocytes, both reduced in about a half of COVID patients, differently from previous studies that reported a main reduction of T lymphocytes [3, 26] and an increase of the percentage and of the absolute number of B lymphocytes, particularly in severe COVID patients [6] . key: cord-318326-q9fnbg8n authors: Cacciapuoti, Sara; De Rosa, Annunziata; Gelzo, Monica; Megna, Matteo; Raia, Maddalena; Pinchera, Biagio; Pontarelli, Agostina; Scotto, Riccardo; Scala, Emanuele; Scarano, Francesco; Scalia, Giulia; Castaldo, Giuseppe; Fabbrocini, Gabriella; Gentile, Ivan; Parrella, Roberto title: Immunocytometric analysis of COVID patients: A contribution to personalized therapy? date: 2020-08-29 journal: Life Sci DOI: 10.1016/j.lfs.2020.118355 sha: doc_id: 318326 cord_uid: q9fnbg8n AIMS: keywords: covid; covid-19; il-6; lymphocytes; number; patients; serum cache: cord-318326-q9fnbg8n.txt plain text: cord-318326-q9fnbg8n.txt item: #2032 of 2876 id: cord-318333-rzhrgp5q author: Hou, Jiabao title: COVID-19 infection, a potential threat to surgical patients and staff? A retrospective cohort study date: 2020-09-03 words: 3271 flesch: 41 summary: Although the SAPS Ⅱ scores in surgical patients with COVID-19 were not higher than that in normal surgical patients, 17 two surgical patients (11.76%) died of COVID-19-associated complications, which was much higher than the reported overall case-fatality rate of 4.3% in COVID-19 patients without surgery 3 and was also higher than the case-fatality rate of 7.9% in noncardiac surgical patients. 20 Interestingly, the numbers, not the distribution, of CD3+ and CD4+ cells in COVID-19 surgical patients were lower than those in mild COVID-19 patients without surgery and were similar to those in severe COVID-19 patients, 21 which meant that COVID-19 seriously inhibited the immune function of T lymphocytes after surgery. keywords: covid-19; infection; patients; pneumonia; staff; study; surgery cache: cord-318333-rzhrgp5q.txt plain text: cord-318333-rzhrgp5q.txt item: #2033 of 2876 id: cord-318355-38x3f3ee author: Yang, Yang title: Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with Sars‐COV‐2 date: 2020-07-17 words: 3963 flesch: 42 summary: There was a moderate correlation between the value of SMD and age, and high IMF deposition was more common in older patients in our study, but high IMF deposition was still a significant risk factor for critical illness when age was adjusted statistically. Furthermore, visceral adiposity or high IMF deposition increased the risk of mechanical ventilation (p=0.013, p<0.001; respectively). keywords: adipose; covid-19; deposition; illness; imf; muscle; patients; tissue; visceral cache: cord-318355-38x3f3ee.txt plain text: cord-318355-38x3f3ee.txt item: #2034 of 2876 id: cord-318369-y3wtfqrn author: Pan, Lingai title: How to optimize the Radiology protocol during the global COVID-19 epidemic: Keypoints from Sichuan Provincial People's Hospital date: 2020-08-05 words: 1247 flesch: 48 summary: One CT machine was arranged in a fixed room only for fever clinic patients .One for emergency patients with or without general respiratory symptoms and two for routine CT(scheduled patients without any respiratory symptoms). In case of clinical suspected patients, launch the MDT consultation, do not miss any suspected patient. keywords: covid-19; epidemic; patients; room cache: cord-318369-y3wtfqrn.txt plain text: cord-318369-y3wtfqrn.txt item: #2035 of 2876 id: cord-318520-hgjv7ot9 author: Mohamed, Sherif title: Death due to Cardiac Arrest in a Young Female With Highly Suspected COVID-19: A Case Report date: 2020-08-30 words: 1949 flesch: 41 summary: As COVID-19 patients are commonly having clotting disorders, endothelial and organ dysfunction, coagulopathy, and liable for pulmonary thromboembolism (PTE), it is important to select those COVID-19 patients who are at higher risk of PTE, and practice CT pulmonary angiography (CTPA) for the diagnosis of PTE, especially in case of significant increase of D-dimer values. Acute pulmonary embolism (PE), reported in COVID-19 patients, has been shown to be a cause of clinical deterioration in viral types of pneumonia, as well [7] . keywords: case; covid-19; disease; patients; pulmonary cache: cord-318520-hgjv7ot9.txt plain text: cord-318520-hgjv7ot9.txt item: #2036 of 2876 id: cord-318694-370ccaoc author: Khanna, Niharika title: Utilizing the Learning Health System Adaptation to guide Family Medicine Practice to COVID-19 response date: 2020-10-16 words: 1613 flesch: 39 summary: Scheduled televisits with COVID-19 positive patients helped allay anxiety, encouraged chronic disease care, tobacco cessation, and medication adherence. There was a pressing need for innovation in order to meet the needs of the population that needed outreach, COVID-19 care and preventive services. keywords: care; covid-19; health; pandemic; patients; staff cache: cord-318694-370ccaoc.txt plain text: cord-318694-370ccaoc.txt item: #2037 of 2876 id: cord-318803-xpa49sxt author: McFee, Robin B. title: Gulf War Servicemen and Servicewomen: The Long Road Home and the Role of Health Care Professionals to Enhance the Troops' Health and Healing date: 2008-05-31 words: 24570 flesch: 50 summary: Given MVA are a leading cause of death among adolescents and clearly a worrisome cause of death among newly returning war veterans, it is important for clinicians to alert troop patients about this risk and the cofactors that are likely to be at play-alcohol and other substance abuse, 77 exhaustion, work, stress, or coping related, medication effect. [116] Military health care includes TRICARE/CHAMPUS (Civilian Health and Medical Program of the Uniformed Services) and CHAMPVA (Civilian Health and Medical Program of the Department of Veterans Affairs), as well as care provided by the Department of Veterans Affairs. keywords: abuse; afghanistan; blast; care; combat; deployment; family; fever; gulf; gulf war; health; health care; illness; illnesses; injuries; injury; iraq; military; patients; persian; ptsd; return; risk; services; symptoms; tbi; trauma; treatment; troops; u.s; veterans; war; women cache: cord-318803-xpa49sxt.txt plain text: cord-318803-xpa49sxt.txt item: #2038 of 2876 id: cord-318808-1cfwj5uq author: Li, Ying title: Comparison of Hospitalized Patients with pneumonia caused by COVID-19 and influenza A in children under 5 years date: 2020-06-12 words: 1656 flesch: 45 summary: Two group of COVID-19 patients (n=57) and influenza A patients (n=59) were enrolled. Results The proportions of cough (70.2%), fever (54.4%) and gastrointestinal symptoms (14.1%) in COVID-19 patients were lower than those of influenza A patients (98.3%, P<0.001; 84.7%, P<0.001; and 35.6%, P=0.007; respectively). keywords: children; covid-19; influenza; patients cache: cord-318808-1cfwj5uq.txt plain text: cord-318808-1cfwj5uq.txt item: #2039 of 2876 id: cord-318830-a3n4c5d1 author: Brook, Olga R. title: Feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients date: 2020-09-17 words: 3857 flesch: 50 summary: Research using autopsy tissue for this project was approved by institutional IRB. In one patient, sampling of the heart was limited, although representative, because of altered anatomy with tissue cores including portions of stomach and lung, likely due to anterior pleural adhesions and hiatal hernia. keywords: autopsy; lung; needle; patients; samples; study; tissue; ultrasound cache: cord-318830-a3n4c5d1.txt plain text: cord-318830-a3n4c5d1.txt item: #2040 of 2876 id: cord-318873-zwot69s3 author: Braunstein, Eric D. title: Inpatient Cardiac Monitoring Using a Patch‐Based Mobile Cardiac Telemetry System During the COVID‐19 Pandemic date: 2020-08-27 words: 4536 flesch: 34 summary: There were 432 total patient-days of mobile telemetry monitoring; of those the QT-interval was able to be measured in 400, 92.6% of the time. A prospective cohort study was performed of inpatients hospitalized during the pandemic who had mobile telemetry devices placed; patients were studied up until the time of discharge or death. keywords: arrhythmias; mobile; monitoring; patients; system; telemetry cache: cord-318873-zwot69s3.txt plain text: cord-318873-zwot69s3.txt item: #2041 of 2876 id: cord-318909-h5b7mncf author: Liguori, Claudio title: Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection date: 2020-05-19 words: 3480 flesch: 38 summary: Although the involvement of nervous system during SARS-CoV2 infection has been extensively proposed, [10] [11] [12] few studies focused the investigation on neurological symptoms in patients with 7 The largest study examining the neurological manifestations of hospitalized patients with COVID-19 was a retrospective analysis achieved by reviewing patients' clinical charts. A part the respiratory illness, an increasing number of reports pointed out that SARS-CoV2 can also affect the nervous system, since neurological manifestations may occur quite frequently in hospitalized patients. keywords: cov2; covid-19; hospitalization; infection; patients; sars; sns cache: cord-318909-h5b7mncf.txt plain text: cord-318909-h5b7mncf.txt item: #2042 of 2876 id: cord-318944-13zk6cco author: Bizzoca, Maria Eleonora title: Covid-19 Pandemic: What Changes for Dentists and Oral Medicine Experts? A Narrative Review and Novel Approaches to Infection Containment date: 2020-05-27 words: 11704 flesch: 45 summary: 7. Before dental session patient should rinse and gargle with a specific mouthwash. The first problem raised with respect to COVID-19, is related to the easy spread of viral agents in the air during dental procedures [12] keywords: agents; air; blood; care; contact; control; covid-19; droplets; gloves; hand; health; human; infection; order; patient; procedures; protection; respiratory; risk; surfaces; transmission; use; virus; water cache: cord-318944-13zk6cco.txt plain text: cord-318944-13zk6cco.txt item: #2043 of 2876 id: cord-318954-pj5lsvsa author: Arabi, Yaseen title: Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol date: 2015-11-19 words: 3968 flesch: 43 summary: The study also has an independent data safety monitoring board (DSMB) which is responsible for reviewing reports submitted to the regarding safety of study patients, protocol adherence and may making recommendations to continue or terminate the study based on safety analysis results. Clinical and laboratory data will be collected at baseline, 30 min after first dose, 30 min after second dose, study days 1, 3, 5, 7, 14, and 28. keywords: cov; days; infection; mers; patients; plasma; study; therapy cache: cord-318954-pj5lsvsa.txt plain text: cord-318954-pj5lsvsa.txt item: #2044 of 2876 id: cord-319013-oytqcifa author: Focosi, Daniele title: Convalescent Plasma Therapy for COVID-19: State of the Art date: 2020-08-12 words: 7487 flesch: 25 summary: A proof of concept single arm multicenter interventional trial Improved clinical symptoms and mortality on severe/critical COVID-19 patients utilizing convalescent plasma transfusion Convalescent plasma treatment of severe COVID-19: a matched control study Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial Early safety indicators of COVID-19 convalescent plasma in 5,000 patients Safety update: COVID-19 convalescent plasma in 20,000 hospitalized patients COVID-19) patients with convalescent plasma Get rid of the bad first: therapeutic plasma exchange with convalescent plasma for severe COVID-19 The successful use of therapeutic plasma exchange for severe COVID-19 acute respiratory distress syndrome with multiple organ failure Efficacy of therapeutic plasma exchange in severe COVID-19 patients Successful treatment of plasma exchange followed by intravenous immunoglobulin in a critically ill patient with 2019 novel coronavirus infection Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19 Global Vaccine Business Unit on the latest on the coronavirus and Takeda Is it time to rethink UK restrictions on blood donation? Hepatitis E virus in blood components: a prevalence and transmission study in southeast England Pork products associated with human infection caused by an emerging phylotype of hepatitis E virus in England and Wales Hepatitis E risks: pigs or blood-that is the question SARS-coronavirus replication in human peripheral monocytes/macrophages Epitopes required for antibody-dependent enhancement of Ebola virus infection Antibodydependent enhancement of Ebola virus infection Influence of Fc␥RIIA and MBL polymorphisms on severe acute respiratory syndrome Immune phenotyping based on neutrophil-tolymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19 Viral kinetics and antibody responses in patients with COVID-19 Global profiling of SARS-CoV-2 specific IgG/IgM responses of convalescents using a proteome microarray Neutralizing antibodies responses to SARS-CoV-2 in COVID-19 inpatients and convalescent patients Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins Anti-SARS-CoV IgG response in relation to disease severity of severe acute respiratory syndrome The potential danger of suboptimal antibody responses in COVID-19 Symptomatic SARS-CoV-2 infections display specific IgG Fc structures Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19 Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study Currently available intravenous immunoglobulin (Gamunex © -C and Flebogamma © DIF) contains antibodies reacting against SARS-CoV-2 antigens High-dose intravenous immunoglobulin as a therapeutic option for deteriorating patients with coronavirus disease 2019 ABO blood group and susceptibility to severe acute respiratory syndrome Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complementmediated inactivation Harnessing the natural anti-glycan immune response to limit the transmission of enveloped viruses such as SARS-CoV-2 Specific asparagine-linked glycosylation sites are critical for DC-SIGN-and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry Structural, glycosylation and antigenic variation between 2019 novel coronavirus (2019-nCoV) and SARS coronavirus (SARS-CoV) After demonstration that blood group O health care workers were less likely to become infected with SARS-CoV (137), a research group proved that anti-A blood group natural isoagglutinins (which can also be found in CP plasma from blood group O and B donors) inhibit SARS-CoV entry into competent cells (138) . keywords: antibodies; antibody; blood; case; convalescent; coronavirus; covid-19; disease; donors; group; patients; plasma; sars; syndrome; therapy; titers; transfusion; treatment cache: cord-319013-oytqcifa.txt plain text: cord-319013-oytqcifa.txt item: #2045 of 2876 id: cord-319037-77l9wdyb author: Gavriilaki, Eleni title: A New Era in Endothelial Injury Syndromes: Toxicity of CAR-T Cells and the Role of Immunity date: 2020-05-29 words: 6412 flesch: 29 summary: The CD3ζ chain provides signals required for T cell activation. Finally, fourth generation CARs are also called TRUCKs (CAR redirected T cells that deliver a transgenic product to the targeted tumor tissue) or armored CARs. keywords: activation; allogeneic; car; cell; complement; endothelial; hct; injury; neurotoxicity; pathway; patients; syndrome; transplantation cache: cord-319037-77l9wdyb.txt plain text: cord-319037-77l9wdyb.txt item: #2046 of 2876 id: cord-319218-mejvlkfg author: Marandino, Laura title: The Shifting Landscape of Genitourinary Oncology During the COVID-19 Pandemic and how Italian Oncologists Reacted: Results from a National Survey date: 2020-04-20 words: 954 flesch: 31 summary: First, Italian oncologists are still in favor of considering delivery of the best treatment option for genitourinary cancer patients through inclusion in clinical trials (61%), although most of them (54%) underlined the unavoidable more stringent selection and the need to face severe logistic difficulties, as indicated in Fig. Besides this consideration, a number of critical dilemmas have emerged regarding indications for cancer therapies and management of associated side effects. keywords: covid-19; oncologists; patients cache: cord-319218-mejvlkfg.txt plain text: cord-319218-mejvlkfg.txt item: #2047 of 2876 id: cord-319333-jwbgytwd author: Radmard, Sara title: Inpatient Neurology Consultations During the Onset of the SARS-CoV-2 New York City Pandemic: A Single Center Case Series date: 2020-07-10 words: 3408 flesch: 41 summary: However, we are not able to comment on how these levels compare to COVID-19 patients without neurologic symptoms in our inpatient population, COVID-19 patients in the outpatient setting, nor to healthy controls. Novel coronavirus infection (COVID-19) in humans: a scoping review and meta-analysis Clinical features of patients infected with 2019 novel coronavirus in Wuhan Neurologic alterations due to respiratory virus infections Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study Neurologic features in severe SARS-CoV-2 infection Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Macrothrombosis and stroke in patients with mild Covid-19 infection Large-vessel stroke as a presenting feature of Covid-19 in the young Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan COVID-19: ICU delirium management during SARS-CoV-2 pandemic Pathological findings of COVID-19 associated with acute respiratory distress syndrome Epidemiology of acute symptomatic seizures among adult medical admissions Seizures associated with coronavirus infections Acute ischaemic stroke and infection: recent and emerging concepts Why now? keywords: cov-2; covid-19; data; disease; infection; patients; sars; stroke cache: cord-319333-jwbgytwd.txt plain text: cord-319333-jwbgytwd.txt item: #2048 of 2876 id: cord-319400-lghjiw5p author: Chaix, B. title: Psychological Distress during the COVID-19 pandemic in France: a national assessment of at-risk populations date: 2020-05-15 words: 3264 flesch: 53 summary: This pandemic also represents a significant concern to cancer patients, who are at high risk of complications due to several predisposing factors (18) (19) (20) . They are also able to provide medical information to breast cancer patients with a level of quality comparable to physicians, as shown in the phase 3 randomized controlled trial INCASE (NCT03556813) (13) . keywords: covid-19; depression; distress; health; patients; pdi; risk; study cache: cord-319400-lghjiw5p.txt plain text: cord-319400-lghjiw5p.txt item: #2049 of 2876 id: cord-319567-4t5t8bcx author: Şentürk, Mert title: Thoracic Anesthesia of Patients with Suspected or Confirmed 2019 Novel Coronavirus Infection: Preliminary Recommendations for Airway Management by the EACTA Thoracic Subspecialty Committee date: 2020-04-11 words: 4329 flesch: 43 summary: Anaesthesia Subspecialty group has considered these challenges and developed a preliminary set of expert recommendations regarding the airway management and ventilation of COVID-19 thoracic patients. The group has considered a broad spectrum of issues regarding thoracic anesthesia in COVID-19 patients and decided to focus on overall approaches to general and specific aspects of airway management, preparation for anaesthesia, lung isolation/separation and ventilation. keywords: airway; anesthesia; cases; covid-19; intubation; management; patients; surgery; thoracic; ventilation cache: cord-319567-4t5t8bcx.txt plain text: cord-319567-4t5t8bcx.txt item: #2050 of 2876 id: cord-319615-p2labgd8 author: Schulman, Sam title: Coronavirus Disease 2019, Prothrombotic Factors, and Venous Thromboembolism date: 2020-05-11 words: 3049 flesch: 41 summary: Most of the events (n ¼ 29) were in ICU patients and 21 of the 33 events were symptomatic with the remainder found through screening for DVT. 22 Stroke was also, albeit at a slightly lower incidence, diagnosed in sepsis patients remaining in sinus rhythm. keywords: care; covid-19; icu; incidence; patients; thromboembolism; venous cache: cord-319615-p2labgd8.txt plain text: cord-319615-p2labgd8.txt item: #2051 of 2876 id: cord-319706-2e9jrv0s author: Ebinger, Joseph E. title: Pre-existing traits associated with Covid-19 illness severity date: 2020-07-23 words: 4912 flesch: 32 summary: For the total sample of Covid-19 patients, we used parametric tests to compare normally distributed continuous variables and non-normally distributed or categorical variables, respectively. CONCLUSIONS AND RELEVANCE: In our healthcare system, greater Covid-19 illness severity is seen in patients who are older, male, African American, obese, with diabetes, and with greater overall comorbidity burden. keywords: age; care; covid-19; illness; intubation; male; patients; risk; severity; sex cache: cord-319706-2e9jrv0s.txt plain text: cord-319706-2e9jrv0s.txt item: #2052 of 2876 id: cord-319742-ypkt01rn author: Asgharpour, Masoumeh title: Effectiveness of extracorporeal blood purification (hemoadsorption) in patients with severe coronavirus disease 2019 (COVID-19) date: 2020-08-20 words: 3502 flesch: 36 summary: The upper limit point of serum IL-6 level in COVID-19 patients who had no severe pneumonia was reported 24.3 pg/mL, and the increased expression of IL-6 in serum is expected to predict the severity of the COVID-19 pneumonia and a poor prognosis of patients [20] . Extracorporeal hemoadsorption could improve the general condition in most of recruited patients with severe coronavirus disease; however, large prospective multicenter trials in carefully selected patients are needed to definitely evaluate the efficacy of hemoperfusion in COVID-19 patients. keywords: blood; covid-19; cytokine; disease; extracorporeal; hemoperfusion; patients; study cache: cord-319742-ypkt01rn.txt plain text: cord-319742-ypkt01rn.txt item: #2053 of 2876 id: cord-319805-b6ypt5d0 author: Siepmann, Timo title: Association of history of cerebrovascular disease with severity of COVID-19 date: 2020-08-06 words: 5102 flesch: 36 summary: Investigation of early cohorts of COVID-19 patients in China focused on the effects of classic cardiovascular risk factors such as arterial hypertension and coronary heart disease or comorbidity in general [6, 7] . To approach this question, we assessed individual multicenter data from three cohorts of COVID-19 patients treated during the first months of the pandemic in Germany. keywords: covid-19; cvd; data; disease; history; patients; risk; severity; studies; study cache: cord-319805-b6ypt5d0.txt plain text: cord-319805-b6ypt5d0.txt item: #2054 of 2876 id: cord-319823-sp5wibeh author: Brown, Sherry-Ann title: Innovation in Precision Cardio-Oncology During the Coronavirus Pandemic and Into a Post-pandemic World date: 2020-08-14 words: 5153 flesch: 17 summary: Telemedicine for Covid-19 Virtual visits for care of patients with heart failure in the Era of COVID-19: a statement from the heart failure society of America COVID-19 Emergency Declaration Blanket Waivers for Health Care Providers A practical approach to the management of cancer patients during the novel coronavirus disease 2019 (COVID-19) pandemic: an international collaborative group Cardio-oncology care in the time of COVID-19 and the role of telehealth Transition to a virtual multidisciplinary tumor board during the COVID-19 pandemic: University of Pittsburgh experience Telehealth transformation: COVID-19 and the rise of virtual care Preventive behaviors conveyed on youtube to mitigate transmission of COVID-19: cross-sectional study The role of youtube and the entertainment industry in saving lives by educating and mobilizing the public to adopt behaviors for community mitigation of COVID-19: successive sampling design study Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study Building trust while influencing online COVID-19 content in the social media world Mining physicians' opinions on social media to obtain insights into COVID-19: mixed methods analysis Measuring the outreach efforts of public health authorities and the public response on facebook during the COVID-19 pandemic in early 2020: cross-country comparison Global sentiments surrounding the COVID-19 pandemic on twitter: analysis of twitter trends Tracking social media discourse about the COVID-19 pandemic: development of a public coronavirus twitter data set Digital technology and COVID-19 Available online at Wearable devices for ambulatory cardiac monitoring: JACC state-of-the-art review Feasibility of a voice-enabled automated platform for medical data collection: cardioCube A protocol integrating remote patient monitoring patient reported outcomes and cardiovascular biomarkers Mobile health in cardiology: a review of currently available medical apps and equipment for remote monitoring Effectiveness of remote patient monitoring after discharge of hospitalized patients with heart failure: the better effectiveness after transition -heart failure (BEAT-HF) randomized clinical trial Impact of remote monitoring on clinical outcomes for patients with heart failure and atrial fibrillation: results from the REM-HF trial Assessment of heart failure patients' interest in mobile health apps for self-care: survey study Value of telemonitoring and telemedicine in heart failure management Wearable technology and how this can be implemented into clinical practice a mobile health platform to disseminate validated institutional measurements during the COVID-19 outbreak: utilizationfocused evaluation study Using mHealth to support COVID-19 education, self-assessment, and symptom monitoring: an observational study in The Netherlands COVID-19 contact tracing and data protection can go together Rapid implementation of a COVID-19 remote patient monitoring program HRS/EHRA/APHRS/LAHRS/ACC/AHA worldwide practice update for telehealth and arrhythmia monitoring during and after a pandemic A web-and app-based connected care solution for COVID-19 in-and outpatient care: qualitative study and application development Efficacy and safety of an mhealth app and wearable device in physical performance for patients with hepatocellular carcinoma: development and usability study A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: the ACTIVATE trial The HOPE pilot study: harnessing patient-reported outcomes and biometric data to enhance cancer care Noninvasive vocal biomarker is associated with pulmonary hypertension Vocal biomarker is associated with hospitalization and mortality among heart failure patients Voice signal characteristics are independently associated with coronary artery disease Increasing physical activity amongst overweight and obese cancer survivors using an alexa-based intelligent agent for patient coaching: protocol for the physical activity by technology help (PATH) trial How Drones are Used for Life-Saving Healthcare 2020 The consequent exponentially increasing genetic knowledge combined with deep cardiovascular phenotyping of cancer patients may allow us to identify genetic variants predicting either increased susceptibility or tolerance for specific drug-induced cardiotoxicity and thereby to risk stratify patients based on their genetic backgrounds (84) . keywords: cancer; cardio; cardiovascular; care; covid-19; data; disease; health; heart; monitoring; oncology; pandemic; patients; survivors cache: cord-319823-sp5wibeh.txt plain text: cord-319823-sp5wibeh.txt item: #2055 of 2876 id: cord-319849-3shr5grg author: Cheruiyot, Isaac title: Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients date: 2020-11-03 words: 3063 flesch: 37 summary: Cerebrovascular disease is associated with an increased disease severity in patients with coronavirus disease 2019 (COVID-19): a pooled analysis of published literature Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study Impact of cerebrovascular and cardiovascular diseases on mortality and severity of COVID-19-systematic review, meta-analysis, and meta-regression Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis Humanitas COVID-19 Task Force (2020) Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases Hypercoagulability of COVID-19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom Acute ischemic stroke complicating common carotid artery thrombosis during a severe COVID-19 infection Hemorrhagic presentations of COVID-19: risk factors for mortality Stroke in patients with SARS-CoV-2 infection: case series Cerebrovascular disease in patients with COVID-19: a review of the literature and case series Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report Hemorrhagic stroke and anticoagulation in COVID-19 Basal ganglia involvement and altered mental status: a unique neurological manifestation of coronavirus disease Neurologically devastating intraparenchymal hemorrhage in COVID-19 patients on extracorporeal membrane oxygenation: a case series Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description A prospective clinical study of detailed neurological manifestations in patients with COVID-19 Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study Neurologic manifestations of hospitalized patients with coronavirus disease Coronavirus disease 2019 and stroke in Iran: a case series and effects on stroke admissions Letter to editor: severe brain haemorrhage and concomitant COVID-19 Infection: a neurovascular complication of COVID-19 Clinical and imaging characteristics in patients with SARS-CoV-2 infection and acute intracranial hemorrhage Neurological manifestations and COVID-19: Thereafter, a pooled analysis incorporating only cohort studies in which all hospitalized patients were studied within a specified period of time was conducted to estimate pooled incidence of intracranial hemorrhage in COVID-19 patients using the Meta-Analyst (software version 5.26.14, Center for Evidence-Based Medicine, Brown University, Providence, USA). keywords: case; covid-19; disease; hemorrhage; ich; patients; stroke; studies cache: cord-319849-3shr5grg.txt plain text: cord-319849-3shr5grg.txt item: #2056 of 2876 id: cord-319930-ymqnb54a author: Kremer, Stéphane title: Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study date: 2020-06-16 words: 3190 flesch: 30 summary: N is the total number of patients with available data, and n the number of positive patients. Describe the neuroimaging findings (excluding ischemic infarcts) in patients with severe COVID-19 infection. keywords: brain; covid-19; data; flair; hemorrhagic; lesions; mri; patients cache: cord-319930-ymqnb54a.txt plain text: cord-319930-ymqnb54a.txt item: #2057 of 2876 id: cord-320149-3q4q98a6 author: Di Carlo, Davide Tiziano title: Exploring the clinical association between neurological symptoms and COVID-19 pandemic outbreak: a systematic review of current literature date: 2020-08-01 words: 3485 flesch: 33 summary: An official clinical practice guideline of the The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses COVID-19 in a designated infectious diseases hospital outside Hubei Province COVID-19 with different severity: a multi-center study of clinical features Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study Olfactory and gustatory dysfunctions as a clinical presentation of mildto-moderate forms of the coronavirus disease (COVID-19): a multicenter European study The clinical and chest CT features associated with severe and critical COVID-19 pneumonia Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan Characteristics of COVID-19 infection in Beijing Clinical features and treatment of COVID-19 patients in northeast Chongqing Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Characteristics of emergency department patients with COVID-19 at a single site in Northern California: clinical observations and public health implications Clinical characteristics and outcomes of COVID-19 patients with a history of stroke in Wuhan China COVID-19 related neuroimaging findings: a signal of thromboembolic complications and a strong prognostic marker of poor patient outcome Imaging in neurological disease of hospitalized COVID-19 patients: an Italian multicenter retrospective observational study Brain imaging use and findings in COVID-19: a single academic center experience in the epicenter of disease in the United States Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study Human Coronaviruses: respiratory pathogens revisited as infectious neuroinvasive, neurotropic, and neurovirulent agents Middle East respiratory syndrome Nervous system involvement after infection with COVID-19 and other coronaviruses The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 Minireview: overview of the renin-angiotensin system-an endocrine and paracrine system Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Multiple organ infection and the pathogenesis of SARS Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 First case of 2019 novel coronavirus disease with encephalitis The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients Respiratory failure alone does not suggest central nervous system invasion by SARS-CoV-2 Reninangiotensin system: an old player with novel functions in skeletal muscle A first case of meningitis/encephalitis associated with SARS-Coronavirus-2 COVID-19-associated meningoencephalitis complicated with intracranial hemorrhage: a case report MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Characteristics of ischaemic stroke associated with COVID-19 COVID-19 presenting as stroke Stroke epidemiology: advancing our understanding of disease mechanism and therapy Hospitalization for infection and risk of acute ischemic stroke: the Cardiovascular Health Study Guillain-Barré syndrome associated with SARS-CoV-2 Early Guillain-Barré syndrome in coronavirus disease 2019 (COVID-19): a case report from an Italian COVID-hospital Miller Fisher syndrome and polyneuritis cranialis in COVID-19 Guillain Barre syndrome associated with COVID-19 infection: a case report Acute symptomatic seizures in critically Ill patients with COVID-19: is there an association? Data were obtained for the whole population and subsequently we divided it into two groups: severe patients and non-severe patients, according to the American Thoracic Society guidelines for community-acquired pneumonia keywords: clinical; coronavirus; covid-19; disease; infection; patients; sars; studies; syndrome cache: cord-320149-3q4q98a6.txt plain text: cord-320149-3q4q98a6.txt item: #2058 of 2876 id: cord-320184-wacoz5t9 author: Thirumalaikolundusubramanian, Ponniah title: Ethics, Legality, and Education in the Practice of Cardiology date: 2014-08-15 words: 8822 flesch: 35 summary: to provide a written notice of their privacy policy to all those who seek medical care for the first time. Periodical analyses of judgments related to health care issues, health care professionals, and health services at national and international levels, as well as identification of the causes, to find methods to avert them can be undertaken at educational and industrial levels. keywords: care; clinical; consent; doctors; education; ethics; health; health care; information; issues; law; medical; medicine; patients; physicians; practice; quality cache: cord-320184-wacoz5t9.txt plain text: cord-320184-wacoz5t9.txt item: #2059 of 2876 id: cord-320267-n21jryi2 author: AlShoaibi, Naeem A. title: Saudi Heart Rhythm Society Task Force on Management of Potential Arrhythmogenicity Associated with Pharmacotherapy for COVID-19 date: 2020-09-20 words: 3494 flesch: 38 summary: 41, 42 On-therapy QT assessment for high risk patients (QT ≥500 ms) should include a QT interval obtained 2-4 hours after the first dose, then again after 48 hours, then 96 hours. While no proven effective intervention exists, it is appropriate ethically to offer these experimental interventions to COVID-19 patients after taking into account all legal considerations. keywords: cardiac; covid-19; hydroxychloroquine; interval; patients; prolongation; risk cache: cord-320267-n21jryi2.txt plain text: cord-320267-n21jryi2.txt item: #2060 of 2876 id: cord-320349-6hbuq0k7 author: Zhou, Hua title: Development of early warning and rapid response system for patients with novel coronavirus pneumonia (COVID-19): A research protocol date: 2020-08-21 words: 3504 flesch: 37 summary: After admission, EWRRS performs an initial assessment of COVID-19 patient disease severity based on past medical history, clinical symptoms, vital signs, and other auxiliary examinations. The intervention is implementation of EWRRS to detect early signs of clinical deterioration of COVID-19 patients, to provide timely and efficient treatment suggestions by the system. keywords: cases; clinical; covid-19; data; patients; symptoms; system; treatment; warning cache: cord-320349-6hbuq0k7.txt plain text: cord-320349-6hbuq0k7.txt item: #2061 of 2876 id: cord-320445-pdvkyzci author: Fry, Alicia M. title: Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand date: 2007-04-01 words: 3908 flesch: 43 summary: The association of HBoV infection with pneumonia requiring hospitalization and with viral coinfections and the clinical and epidemiologic characteristics of HBoV infections during the study period are described. We compared HBoV infection in patients with pneumonia with that in asymptomatic control patients enrolled between 1 September 2004 and 31 August 2005 in the same hospitals in Thailand. keywords: children; hbov; illness; infection; patients; pneumonia; viruses cache: cord-320445-pdvkyzci.txt plain text: cord-320445-pdvkyzci.txt item: #2062 of 2876 id: cord-320477-zbp8a8dr author: Fung, Timothy H.M. title: Addressing COVID‐19 fear to improve clinic attendance for patients with wet age‐related macular degeneration date: 2020-06-18 words: 695 flesch: 45 summary: Patients who attended were provided with a self-completion survey whilst a telephone survey was conducted for patients who did not attend their appointment. key: cord-320477-zbp8a8dr authors: Fung, Timothy H.M.; Kuet, Mong‐Loon; Patel, Moneesh K.; Puri, Pankaj title: Addressing COVID‐19 fear to improve clinic attendance for patients with wet age‐related macular degeneration date: 2020-06-18 journal: Acta Ophthalmol DOI: 10.1111/aos.14520 sha: doc_id: 320477 cord_uid: zbp8a8dr nan I n line with the recommendations from national (Royal College of Ophthalmologists, 2020) and international (American Academy of Ophthalmology, 2020) ophthalmology societies, only urgent or emergent care is being provided in our ophthalmology department. keywords: clinic; patients cache: cord-320477-zbp8a8dr.txt plain text: cord-320477-zbp8a8dr.txt item: #2063 of 2876 id: cord-320572-94fvtj4a author: Wendel Garcia, Pedro David title: Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort date: 2020-07-06 words: 5418 flesch: 38 summary: Following the critical developments in ICUs in regions experiencing early inception of the pandemic, the European-based, international RIsk Stratification in COVID-19 patients in the Intensive Care Unit (RISC-19-ICU) registry was created to provide near real-time assessment of patients developing critical illness due to COVID-19. Following the critical spread of the disease in China, Italy and Spain, on March 13, 2020 the European-based RIsk Stratification in COVID-19 patients in the ICU (RISC-19-ICU) registry was launched to allow nearreal time assessment of the main clinical characteristics of critically ill patients during the emerging COVID-19 pandemic. keywords: acute; analysis; care; covid-19; data; disease; icu; model; mortality; patients; registry; study; survivors cache: cord-320572-94fvtj4a.txt plain text: cord-320572-94fvtj4a.txt item: #2064 of 2876 id: cord-320599-hxn4bgec author: Liontos, Michalis title: Chemotherapy resumption in ovarian cancer patient diagnosed with COVID-19 date: 2020-07-30 words: 807 flesch: 46 summary: Cancer patients on chemotherapy may develop SARS-CoV-2 antibodies less frequently. Taken into account these issues, most 34 national and international oncological societies have issued guidelines that assist 35 management of cancer patients throughout this crisis [3] . keywords: cancer; covid-19; patient cache: cord-320599-hxn4bgec.txt plain text: cord-320599-hxn4bgec.txt item: #2065 of 2876 id: cord-320612-vam0bli3 author: Höring, Steffen title: Management of a Hospital-Wide COVID-19 Outbreak Affecting Patients and Healthcare Workers date: 2020-10-26 words: 3417 flesch: 44 summary: The reduction of contacts between geriatric patients was partially challenging since several patients suffered from cognitive impairment and did not follow social distancing recommendations or single-room isolation. Most affected patients were bedridden and had no contact with other patients. keywords: cov-2; covid-19; hospital; infection; outbreak; patients; sars cache: cord-320612-vam0bli3.txt plain text: cord-320612-vam0bli3.txt item: #2066 of 2876 id: cord-320632-369kax2m author: Song, Yang title: COVID-19 Treatment: Close to a Cure? – A Rapid Review of Pharmacotherapies for the Novel Coronavirus date: 2020-07-04 words: 5670 flesch: 42 summary: In another prospective observational study, IVIG was used in SARS patients with severe leukopenia or thrombocytopenia, and it appeared to be effective for controlling cytopenia by increasing leukocyte and platelet counts. In COVID-19 patients with ARDS, treatment with steroids is associated with decreased risk of death compared to the patients who did not receive steroids (46% vs 61.8%) keywords: clinical; coronavirus; covid-19; disease; group; lpv; patients; remdesivir; ribavirin; sars; study; syndrome; therapy; treatment cache: cord-320632-369kax2m.txt plain text: cord-320632-369kax2m.txt item: #2067 of 2876 id: cord-320634-x7a3k5xu author: Salna, Michael title: Reply: A problem of “ethic” proportions date: 2020-08-11 words: 844 flesch: 44 summary: Clinical wards once uncomfortable caring for patients requiring nonrebreather masks managed dozens of ventilated patients, providers who had never set foot in an ICU mastered ventilator optimization to reduce peak and plateau pressures, and mammography technicians learned to use chest radiograph machines. Commentary: Implications of COVID-19 for cardiac surgery: priorities and decisions Adverse events while awaiting myocardial revascularization: a systematic review and meta-analysis The rapid transformation of cardiac surgery practice in the COVID-19 pandemic: insights and keywords: life; patient; years cache: cord-320634-x7a3k5xu.txt plain text: cord-320634-x7a3k5xu.txt item: #2068 of 2876 id: cord-320663-xypg6evo author: Market, Marisa title: Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies date: 2020-06-23 words: 14058 flesch: 29 summary: A natural killer cell receptor for HLA-B allotypes Molecular clones of the p58 NK cell receptor reveal immunoglobulinrelated molecules with diversity in both the extra-and intracellular domains HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b) TLR-mediated activation of NK cells and their role in bacterial/viral immune responses in mammals Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection Human NK cells and herpesviruses: mechanisms of recognition, response and adaptation Cytokine regulation of natural killer cell effector functions Coordinated and distinct roles for IFN-αβ, IL-12, and IL-15 regulation of NK cell responses to viral infection Developmental and functional control of natural killer cells by cytokines. Despite their vital role in viral infection, the contribution of NK cells in fighting SARS-CoV-2 has not yet been directly investigated. keywords: acute; cancer; cells; coronavirus; cov-2; covid-19; cytokine; disease; human; ifn; immune; infection; killer; levels; mers; nk cells; patients; respiratory; response; role; sars; studies; syndrome; therapy; type cache: cord-320663-xypg6evo.txt plain text: cord-320663-xypg6evo.txt item: #2069 of 2876 id: cord-320695-gq7k331z author: Sairras, Shellice title: Heart Failure Hospitalizations and Risk Factors among the Multi-Ethnic Population from a Middle Income Country: The Suriname Heart Failure Studies date: 2020-09-11 words: 4239 flesch: 40 summary: The aim of this Suriname Heart Failure I (SUHF–I) study, is to assess baseline characteristics of HF admitted patients in order to set up the prospective interventional SUHF-II study to longitudinally determine the effectiveness of a comprehensive HF management program in HF patients. Currently, the Thorax Center Paramaribo (TCP), the reference center for cardiac care in Suriname, is developing a comprehensive HF program to improve the delivery of healthcare to HF patients and improve their quality of life with the aim to reduce HF re (hospitalizations). keywords: admissions; factors; failure; heart; management; patients; risk; study; suriname cache: cord-320695-gq7k331z.txt plain text: cord-320695-gq7k331z.txt item: #2070 of 2876 id: cord-320788-ln8ddyuj author: Wang, Chun-Hua title: Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS date: 2005-05-11 words: 4407 flesch: 44 summary: Persistent high-resolution computed tomography (HRCT) abnormalities occur in SARS patients up to 40 days after recovery. At 60 days, compared to normal controls, SARS patients had increased cellularity of BALF with increased alveolar macrophages (AM) and CD8 cells. keywords: bal; cd8; cells; days; hrct; patients; sars; score; syndrome; therapy; virus cache: cord-320788-ln8ddyuj.txt plain text: cord-320788-ln8ddyuj.txt item: #2071 of 2876 id: cord-320811-9sm7iz5x author: Harkin, Denis W. title: Ethics for surgeons during the COVID-19 pandemic, review article date: 2020-06-08 words: 3530 flesch: 38 summary: However, it is vital that infection prevention and control measures are robust, patients risk stratified by COVID-19 testing and staff protected with personalprotective equipment (PPE) and environmental shielding, otherwise isolated or sick staff will further deplete surgical care. Reference Guide to Consent for Examination or Treatment Interventions to Improve Patient Comprehension in Informed Consent for Medical and Surgical Procedures: An Updated Systematic Review Implications for the use of telehealth in surgical patients during the COVID-19 pandemic World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects Economic Recovery After the COVID-19 Pandemic: Resuming Elective Orthopedic Surgery and Total Joint Arthroplasty Medical error in the care of the unrepresented: disclosure and apology for a vulnerable patient population â�¢ The Covid-19 pandemic is a devastating global healthcare emergency with seismic impact on how modern surgical services function.â�¢ Surgeons worry, that whilst healthcare-resources are directed against the pandemic, double effect may predict these benevolent public health efforts will cause unintended maleficent effects through delays to surgical treatment.â�¢ The practice of surgery is distinguished by good judgement in the face of uncertainty, we must strive to act ethically, do the right thing, advocate for our patients, and be honest in the face of uncertainty. keywords: care; covid-19; healthcare; medical; pandemic; patients; surgeons cache: cord-320811-9sm7iz5x.txt plain text: cord-320811-9sm7iz5x.txt item: #2072 of 2876 id: cord-320831-owfnttqr author: Klimek, Ludger title: Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA: Position paper of the German ARIA Group(A) in cooperation with the Austrian ARIA Group(B), the Swiss ARIA Group(C), German Society for Applied Allergology (AEDA)(D), German Society for Allergology and Clinical Immunology (DGAKI)(E), Society for Pediatric Allergology (GPA)(F) in cooperation with AG Clinical Immunology, Allergology and Environmental Medicine of the DGHNO-KHC(G) and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-05-28 words: 3690 flesch: 36 summary: AIT aims at inducing allergen-specific immune tolerance in allergic patients by utilizing effects on several immune mechanisms (Table 1) , including T cells, B cells, innate lymphoid cells (ILCs), and effector cells, such as eosinophils, mast cells, and basophils The start of AIT in allergic patients without known SARS-CoV-2 exposure who do not show COVID-19 symptoms, but whose current SARS-CoV-2 infection and immune status are unknown, requires a thorough examination for signs of SARS-CoV-2 infection during the indication for AIT, and the same examination should be repeated at the start of AIT. keywords: ait; allergen; allergy; cells; covid-19; disease; immunotherapy; infection; patients; risk; sars; symptoms cache: cord-320831-owfnttqr.txt plain text: cord-320831-owfnttqr.txt item: #2073 of 2876 id: cord-320864-k9zksbyt author: Remes-Troche, J. M. title: Recommendations for the reopening and activity resumption of the neurogastroenterology units in the face of the COVID-19 pandemic. Position of the Sociedad Latinoamericana de Neurogastroenterología date: 2020-11-01 words: 4674 flesch: 40 summary: but due to the fact that the epidemiologic behavior, protective equipment avail-ability, serologic diagnostic test performance capacity for corroborating immunity, and socioeconomic context are different throughout Latin America, a group of experts that are members of the Sociedad Latinoamericana de Neurogastroenterología (SLNG) had a virtual meeting to formulate a consensus document with recommendations for the performance of gastrointestinal motility tests. According to the International Anorectal Physiology Working Group (IAPWG) and the London classification, the conventional indications for performing anorectal function tests (primarily anorectal manometry [ARM]) 17 are: 1) constipation and/or defecation disorder symptom evaluation, 2) fecal incontinence (FI) evaluation, 3) painful anorectal disorder evaluation, 4) preoperative and postoperative evaluation of ileorectal anastomoses, rectopexy, fistulotomies, etc., and 5) evaluation of obstetric trauma. keywords: case; country; covid-19; infection; motility; pandemic; patients; performance; recommendations; risk; tests; use cache: cord-320864-k9zksbyt.txt plain text: cord-320864-k9zksbyt.txt item: #2074 of 2876 id: cord-320877-1i0hzfjk author: KIYKAÇ ALTINBAŞ, Şadıman title: Gynecological laparoscopic surgery in the shade of COVID-19 pandemic date: 2020-06-23 words: 2815 flesch: 40 summary: Since January, in the three months, changing in the actual policies and getting out of the routine, the decision of the route of surgery either by traditional open surgery or laparoscopic surgery is being discussed and stated regarding surgical safety concerns [2] . Recently, international societies have made recommendations based on published reasonable data and expert opinion about laparoscopic surgery during coronavirus outbreak. keywords: covid-19; laparoscopy; pandemic; patients; surgery; transmission; use cache: cord-320877-1i0hzfjk.txt plain text: cord-320877-1i0hzfjk.txt item: #2075 of 2876 id: cord-320892-dcfi5u04 author: Kaidi, Austin C. title: Timing and Tips for Total Hip Arthroplasty in a Critically Ill COVID-19 Patient with a Femoral Neck Fracture: A Case Report date: 2020-07-14 words: 1297 flesch: 32 summary: A Meta-Analysis and Meta-Regression 228 of over 190,000 Patients Early 231 and ultra-early surgery in hip fracture patients improves survival Early Surgery Confers 1-Year Mortality Benefit 234 in Hip-Fracture Patients Hip Fracture 237 Covid-19 in Critically Ill Patients in the 239 Seattle Region -Case Series Characteristics and Early Prognosis of 241 COVID-19 Infection in Fracture Patients Novel Coronavirus Infection in Clinical course and risk factors for mortality of adult inpatients 249 with COVID-19 in Wuhan, China: a retrospective cohort study The effect of intravertebral anesthesia on bone cement 252 implantation syndrome in aged patients A single-center 5-year retrospective study Hypercoagulability Syndrome in Patients With Coronavirus Disease Critically Ill Expert consensus on management principles of 259 orthopedic emergency in the epidemic of coronavirus disease 2019 Preventive strategy for the clinical treatment of hip fractures in 262 the elderly during the COVID-19 outbreak: Wuhan’s experience Understanding Bone Cement Implantation Syndrome Postoperative 276 30-day complications after cemented/hybrid versus cementless total hip arthroplasty in 277 osteoarthritis patients > 70 years: A multicenter study from the Lundbeck Foundation 278 Centre for Fast-track Hip and Knee replacement database and the Danish Hip Arthroplasty 279 Diagnosis and management of bone cement 281 implantation syndrome: Case report and brief review Complications of cemented long-stem hip 284 arthroplasties in metastatic bone disease A 70-year-old man with intraoperative hypoxia and 287 hypotension during total hip replacement Total Hip Arthroplasty or Hemiarthroplasty 290 for Hip Fracture However, the optimal timing of surgery in patients with novel coronavirus disease 2019 (COVID-19) infection remains unknown. keywords: covid-19; fracture; hip; patient cache: cord-320892-dcfi5u04.txt plain text: cord-320892-dcfi5u04.txt item: #2076 of 2876 id: cord-320930-9yiu0080 author: Liu, Zeming title: Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan date: 2020-07-14 words: 3153 flesch: 46 summary: We found that COVID-19 patients with DM were older and the proportion of patients with cardiovascular disease were higher among COVID-19 patients with DM than COVID-19 patients without DM. Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. keywords: cases; covid-19; diabetes; disease; patients; study cache: cord-320930-9yiu0080.txt plain text: cord-320930-9yiu0080.txt item: #2077 of 2876 id: cord-321030-isc3p46t author: Rodriguez Socarrás, Moises title: Telemedicine and Smart Working: Recommendations of the European Association of Urology date: 2020-07-10 words: 4621 flesch: 47 summary: It is expected that many patients will spend long periods of confinement at home, so the occurrence/exacerbation of urological symptoms or the interruption of follow-up may generate anxiety and a feeling of helplessness. Many patients will need requisitions for laboratory or imaging tests, some of them with relative urgency. keywords: care; covid-19; data; face; health; pandemic; patients; telemedicine; urology; use; working cache: cord-321030-isc3p46t.txt plain text: cord-321030-isc3p46t.txt item: #2078 of 2876 id: cord-321064-pe8466n1 author: Saraceni, Francesco title: Severe COVID‐19 in a patient with chronic graft‐versus‐host disease after hematopoietic stem cell transplant successfully treated with ruxolitinib date: 2020-07-14 words: 1090 flesch: 37 summary: In vitro antiviral activity and projection of optimized dosing design of Hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey A journey through infectious risk associated with ruxolitinib Ruxolitinibassociated infections: a systematic review and meta-analysis A trial of Lopinavir-Ritonavir in adults hospitalized with severe covid-19 COVID-19: combining antiviral and anti-inflammatory treatments COVID-19: consider cytokine storm syndromes and immunosuppression Baricitinib as potential treatment for 2019-nCoV acute respiratory disease Clinical features of patients infected with 2019 novel coronavirus in Wuhan Pathological findings of COVID-19 associated with acute respiratory distress syndrome Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease Pharmacologic inhibition of JAK1/JAK2 signaling reduces experimental murine acute GVHD while preserving GVT effects Ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease Efficacy, safety and survival with ruxolitinib in patients with myelofibrosis: results of a median 2-year follow-up of COMFORT-I Severe COVID-19 in a patient with chronic graft-versushost disease after hematopoietic stem cell transplant successfully treated with ruxolitinib He was then discharged with a follow-up appointment scheduled 3 months later, confirming ruxolitinib treatment up to the next visit. keywords: cell; covid-19; ruxolitinib; treatment cache: cord-321064-pe8466n1.txt plain text: cord-321064-pe8466n1.txt item: #2079 of 2876 id: cord-321149-hffj7s4o author: Schmidt, Matthieu title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 words: 5370 flesch: 41 summary: Systemic inflammatory response syndrome is a major contributor to COVID-19-associated coagulopathy: insights from a prospective single center cohort study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Severe pulmonary embolism in COVID-19 patients: a call for increased awareness High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Mechanical ventilation management during extracorporeal membrane oxygenation for acute respiratory distress syndrome. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome and posterior probability of mortality benefit in a post hoc Bayesian analysis of a randomized clinical trial Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19) Extracorporeal life support organization coronavirus disease 2019 interim guidelines: a consensus document from an international group of interdisciplinary extracorporeal membrane oxygenation providers Preparing for the most critically ill patients with COVID-19: the potential role of extracorporeal membrane oxygenation Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): pooled analysis of early reports Extracorporeal membrane oxygenation for coronavirus disease 2019-induced acute respiratory distress syndrome: a multicenter descriptive study COVID-19, ECMO, and lymphopenia: a word of caution Clinical management of severe acute respiratory infection when COVID-19 disease is suspected The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material Emergency circulatory support in refractory cardiogenic shock patients in remote institutions: a pilot study (the cardiac-RESCUE program) Retrieval of severe acute respiratory failure patients on extracorporeal membrane oxygenation: any impact on their outcomes? keywords: ards; care; covid-19; ecmo; extracorporeal; hospital; icu; membrane; oxygenation; patients; pressure; state cache: cord-321149-hffj7s4o.txt plain text: cord-321149-hffj7s4o.txt item: #2080 of 2876 id: cord-321237-ynhdii60 author: Shahroor, S. H. title: Adaptive split ventilator system enables parallel ventilation, individual monitoring and ventilation pressures control for each lung simulators date: 2020-04-17 words: 3814 flesch: 44 summary: As in single patient ventilation, the alarm of low MV went off, the inspiratory TV as the expiratory TV measures were lower than before .We The split ventilator succeeded in supporting each simulated patient in balanced ventilation distribution with no disturbances while being challenged with clinical events of Co-vent patient. keywords: control; lung; patient; preprint; setup; split; ventilator cache: cord-321237-ynhdii60.txt plain text: cord-321237-ynhdii60.txt item: #2081 of 2876 id: cord-321311-v2i1caug author: Weller, Michael title: How we treat patients with brain tumour during the COVID-19 pandemic date: 2020-05-13 words: 2746 flesch: 33 summary: Patients with curatively operated tumours, for example, schwannomas or meningiomas, who have no evidence of recurrent disease must not be placed in the same category as patients with recurrent glioblastoma, but having a brain tumour is still often perceived as stigmatising. key: cord-321311-v2i1caug authors: Weller, Michael; Preusser, Matthias title: How we treat patients with brain tumour during the COVID-19 pandemic date: 2020-05-13 journal: ESMO Open DOI: 10.1136/esmoopen-2020-000789 sha: doc_id: 321311 cord_uid: v2i1caug The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. keywords: cancer; care; covid-19; patients; risk cache: cord-321311-v2i1caug.txt plain text: cord-321311-v2i1caug.txt item: #2082 of 2876 id: cord-321346-epsp3bbm author: Luppa, Peter B. title: Point-of-care testing (POCT): Current techniques and future perspectives date: 2011-03-21 words: 4896 flesch: 46 summary: In the past few years, the market for POCT systems grew yearly by more than 10%, but this rapid growth has been slightly dampened since 2007. Type 5 -Continuous measurement with POCT systems. keywords: analysis; blood; care; detection; laboratory; patient; poct; results; sample; systems; testing; time; usa; use cache: cord-321346-epsp3bbm.txt plain text: cord-321346-epsp3bbm.txt item: #2083 of 2876 id: cord-321461-1s3y9kc5 author: Rajdev, Kartikeya title: Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence date: 2020-08-31 words: 2474 flesch: 42 summary: Physicians should have a low threshold for suspecting stroke in COVID-19 patients, and close observation should be kept on such patients particularly those with clinical evidence of traditional risk factors. However, treating physicians should have a low threshold for suspecting stroke in COVID-19 patients, and close observation should be kept on such patients particularly those with clinical evidence of traditional risk factors. keywords: ace2; covid-19; ischemic; patient; risk; stroke cache: cord-321461-1s3y9kc5.txt plain text: cord-321461-1s3y9kc5.txt item: #2084 of 2876 id: cord-321472-n4nnmlv1 author: Oliveira, E. title: ICU Outcomes and Survival in Patients with Severe COVID-19 in the Largest Health Care System in Central Florida date: 2020-08-31 words: 4020 flesch: 41 summary: No evidence of rapid antiviral clearance or clinical benefit with the combination of hydroxychloroquine and azithromycin in patients with severe COVID-19 infection A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 Convalescent plasma as a potential therapy for COVID-19 Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients with Acute Respiratory Distress Syndrome: A Randomized Clinical Trial Prone positioning in severe acute respiratory distress syndrome The Surviving Sepsis Campaign Bundle: 2018 update Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease A study on the efficacy of APACHE-IV for predicting mortality and length of stay in an intensive care unit in Iran Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Management of COVID-19 Respiratory Distress Past and Present ARDS Mortality Rates: A Systematic Review COVID-19 and African Americans The Relationship of Health Insurance and Mortality: Is Lack of Insurance deadly? Effects of temperature variation and humidity on the death of COVID-19 in Wuhan Innovation and Transformation in the Response to Covid-19: Seven Areas Where Clinicians Need to Lead Clinical outcomes in COVID-19 patients treated with tocilizumab: An individual patient data systematic review Treatment with Convalescent Plasma for Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): Pooled analysis of early reports Evaluating the efficacy of dexamethasone in the treatment of patients with persistent acute respiratory distress syndrome: study protocol for a randomized controlled trial Dexamethasone treatment for the acute respiratory distress syndrome: a multicenter, randomized controlled trial We would like to acknowledge the following AdventHealth Critical Care Consortium Research Observations from Wuhan have shown mortality rates of approximately 52% in COVID-19 patients with ARDS keywords: care; covid-19; icu; license; mortality; outcomes; patients; preprint; study cache: cord-321472-n4nnmlv1.txt plain text: cord-321472-n4nnmlv1.txt item: #2085 of 2876 id: cord-321543-qdmvn44h author: Webb, J. B. title: Computational Simulation to Assess Patient Safety of Uncompensated COVID-19 Two-patient Ventilator Sharing Using the Pulse Physiology Engine date: 2020-05-26 words: 5537 flesch: 37 summary: We undertook a computational simulation of dual patient ventilation with a single ventilator using a computational whole-body simulation model to produce informed clinical parameters addressing noted assumptions and assertions. [21] and no computational simulation literature to inform multiple patient shared ventilation, nor specific definition of similar mechanical support needs [16] . keywords: compliance; covid-19; license; lung; model; parameters; patient; preprint; pulse; simulation; ventilator cache: cord-321543-qdmvn44h.txt plain text: cord-321543-qdmvn44h.txt item: #2086 of 2876 id: cord-321552-lsz1onrj author: Membrilla, Javier A. title: Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross‐Sectional Study date: 2020-09-28 words: 4354 flesch: 43 summary: In migraine patients, COVID-19 headache tends to last longer, is more severe and presents earlier in the course of the disease than in patients without migraine. We found that patients with migraine tend to have longer and more intense episodes of COVID-19 headaches. keywords: covid-19; headache; migraine; pain; patients; sars; study; symptoms cache: cord-321552-lsz1onrj.txt plain text: cord-321552-lsz1onrj.txt item: #2087 of 2876 id: cord-321594-x5wv9p7n author: Jiang, Wen title: Equal Access to Telemedicine during COVID‐19 Pandemic: A Pediatric Otolaryngology Perspective date: 2020-10-05 words: 3334 flesch: 47 summary: We evaluated the percentage of telemedicine visits completed by patients whose primary language is Spanish or other languages and compared it to the percentage of in-person visits completed. We conducted a retrospective review of telemedicine visits completed between March 23 and May 1, 2020 when our pediatric otolaryngology clinic was closed for routine outpatient visits due to county-mandated stay-at-home restrictions during the COVID-19 pandemic. keywords: access; care; level; patients; technology; telemedicine; visits cache: cord-321594-x5wv9p7n.txt plain text: cord-321594-x5wv9p7n.txt item: #2088 of 2876 id: cord-321651-7e8dwcur author: Jazieh, Abdul-Rahman title: Managing Oncology Services During a Major Coronavirus Outbreak: Lessons From the Saudi Arabia Experience date: 2020-03-27 words: 2728 flesch: 44 summary: Patients were transported via hospital ambulance if their condition was unstable; patients in stable condition were transferred by private car. The main objectives of this committee were to communicate to the oncology department staff the information received from the daily Hospital Command Center meetings, discuss the current status of the outbreak in the whole hospital, and assess the risk for oncology patients. keywords: cancer; care; infection; oncology; patients; plan; staff cache: cord-321651-7e8dwcur.txt plain text: cord-321651-7e8dwcur.txt item: #2089 of 2876 id: cord-321697-yua3apfi author: Crigna, Adriana Torres title: Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope? date: 2020-10-29 words: 10912 flesch: 32 summary: In breast tumour studies, many differentially expressed miRNA have been detected in breast cancer patients compared with healthy women. Additionally, 4 upregulated plasma miRNA (miR-148b, miR-376c, miR-409-3p and miR-801) managed to discriminate breast cancer patients from controls [166] . keywords: analysis; biomarkers; blood; breast; cancer; cell; cfdna; crc; detection; diabetes; disease; dna; levels; lung; mirna; patients; patterns; plasma; potential; prostate; serum; stress; study; tumour cache: cord-321697-yua3apfi.txt plain text: cord-321697-yua3apfi.txt item: #2090 of 2876 id: cord-321748-9a54ekac author: Kim, Sang Il title: Walk-Through Screening Center for COVID-19: an Accessible and Efficient Screening System in a Pandemic Situation date: 2020-04-14 words: 2852 flesch: 53 summary: For these reasons, SAFETY and the SAFETY-based WT center were designed. At the entrance of the waiting zone, there was a tablet personal computer (PC) for registration and chairs were placed inside the waiting zone to allow waiting patients to sit > 2 m apart. keywords: booth; center; disinfectant; patient; screening cache: cord-321748-9a54ekac.txt plain text: cord-321748-9a54ekac.txt item: #2091 of 2876 id: cord-321768-oevswvvd author: Duan, Ya-qi title: Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients date: 2020-08-07 words: 2311 flesch: 44 summary: We found a dominant presence of macrophages and a general deficiency of T cells and B cells in the lung tissues from deceased COVID-19 patients. In summary, our data highlight a defect of germinal center structure in deceased COVID-19 patients leading to an impaired humoral immunity. keywords: cells; covid-19; lung; patients; tissues cache: cord-321768-oevswvvd.txt plain text: cord-321768-oevswvvd.txt item: #2092 of 2876 id: cord-321784-nubu5fuz author: Salazar, E. title: Treatment of COVID-19 Patients with Convalescent Plasma in Houston, Texas date: 2020-05-13 words: 3568 flesch: 54 summary: Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients Use of convalescent plasma therapy in SARS patients in Hong Kong Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Global initiative on sharing all influenza data -from vision to reality Convalescent plasma as a potential therapy for COVID The effectiveness of convalescent etiology: a systematic review and exploratory meta-analysis Clinical characteristics of fatal and recovered cases of Effective treatment of severe COVID-19 patients with tocilizumab GS-5734™) in Participants With Severe Coronavirus Disease (COVID-19) National Institutes of Health. https://doi.org/10.1101/2020.05.08.20095471 doi: medRxiv preprint A confounding variable in many convalescent plasma studies is the addition of other treatment regimens, such as antivirals and anti-inflammatory compounds. keywords: convalescent; covid-19; medrxiv; patients; plasma; preprint; sars; transfusion cache: cord-321784-nubu5fuz.txt plain text: cord-321784-nubu5fuz.txt item: #2093 of 2876 id: cord-321788-z2y1ywdq author: Dong, J. title: Chest CT Scan of Hospitalized Patients with COVID-19: A Case-Control Study date: 2020-04-11 words: 1993 flesch: 53 summary: Patients in this study were different from Wuhan patients in the paper 3 . Methods: We proposed to use a retrospective case-control study to give a comparison between suspected patients and confirmed patients in the clinical characteristics. keywords: clinical; medrxiv; patients; preprint cache: cord-321788-z2y1ywdq.txt plain text: cord-321788-z2y1ywdq.txt item: #2094 of 2876 id: cord-321801-w66v5kzh author: Grabala, Jolanta title: Possibilities of using ultrasound for diagnosis of invasive pulmonary mucormycosis – A case study date: 2017-08-31 words: 2460 flesch: 32 summary: key: cord-321801-w66v5kzh authors: Grabala, Jolanta; Grabala, Michał; Onichimowski, Dariusz; Grabala, Paweł title: Possibilities of using ultrasound for diagnosis of invasive pulmonary mucormycosis – A case study date: 2017-08-31 journal: Polish Annals of Medicine DOI: 10.1016/j.poamed.2016.11.004 sha: doc_id: 321801 cord_uid: w66v5kzh Abstract Introduction Mucormycosis is a rare but highly lethal fungal infection, usually affecting immunocompromised patients. Aim To present and analyze the diagnostic capabilities of transthoracic ultrasonography in invasive pulmonary mucormycosis. keywords: diagnosis; fungal; lung; mucormycosis; patient; pulmonary; tus cache: cord-321801-w66v5kzh.txt plain text: cord-321801-w66v5kzh.txt item: #2095 of 2876 id: cord-321837-0r86qxz1 author: Zimmerman, Peta-Anne title: A healthy degree of suspicion: A discussion of the implementation of transmission based precautions in the emergency department date: 2016-08-31 words: 3579 flesch: 36 summary: Reported versus observed adherence to contact precautions: a pilot study Here's what U.S. health experts learned from ebola one year later Lessons learned: protection of healthcare workers from infectious disease risks Emerging and re-emerging infectious diseases: a potential pandemic threat Risk of infection following a visit to the emergency department: a cohort study The initial hospital response to an epidemic Measuring social contacts in the emergency department The use and need for standard precautions and transmission-based precautions in the emergency department Health care-acquired viral respiratory diseases Emergency department triage revisited Infection control management of patients with suspected highly infectious diseases in emergency departments: data from a survey in 41 facilities in 14 European countries Novel influenza A (H1N1) virus infections among health-care personnel -United States Tuberculosis transmission risk and infection control in a hospital emergency department in Lima Factors related to missed diagnosis of incidental scabies infestations in patients admitted through the emergency department to inpatient services The 2003 SARS outbreak and its impact on infection control practices The potential to transmit Mycobacterium tuberculosis at a South African tertiary teaching hospital TB infection prevention and control experiences of South African nurses -a phenomenological study Outbreak of acute gastroenteritis among emergency department staff Appraisal of recommended respiratory infection control practices in primary care and emergency department settings Pertussis in an elderly Asian-American man: a case report Emergency department presentation of children with tuberculosis Infection control in the management of highly pathogenic infectious diseases: consensus of the European Network of Infectious Disease A 37-year-old man with confusion, rash, and severe leg pain Community-associated methicillin-resistant Staphylococcus aureus: implications for emergency department nursing Community-associated methicillin-resistant Staphylococcus aureus Medical consequences of biological warfare: the ten commandments of management Emergency department evaluation of the febrile traveler Respiratory hygiene in the emergency department Health care workers' perceptions of respiratory and gastrointestinal algorithms for patient management in emergency care settings Nurses and the control of infectious diseases: understanding epidemiology and disease transmission is vital to nursing care Emergency care staff can improve survival rates from sepsis A curriculum for training healthcare workers in the management of highly infectious diseases The prevalence and triage characteristics of patients presenting with infection to one tertiary referral hospital Predicting pertussis in a pediatric emergency department population Changing health care worker behavior in relation to respiratory disease transmission with a novel training approach that uses biosimulation Emergency departments (EDs) in the United Kingdom (UK) are not prepared for emerging biological threats and bioterrorism Respiratory hygiene in emergency departments: compliance, beliefs, and perceptions An intervention to improve compliance with transmission precautions for influenza in the emergency department: successes and challenges Evaluation of preprocessing techniques for chief complaint classification Fever detection from free-text clinical records for biosurveillance Pandemic influenza triage in the clinical setting Evaluation of syndromic algorithms for detecting patients with potentially transmissible infectious diseases based on computerised emergency-department data Evaluation of natural language processing from emergency department computerized medical records for intra-hospital syndromic surveillance Syndromic surveillance: hospital emergency department participation during the Kentucky Derby Festival Point-of-care tests for infection control: should rapid testing be in the laboratory or at the front line? Emergency department clinical staff, particularly those who have first contact with presenting patients, must be familiar with common infectious disease as well as those that are emerging or re-emerging locally and globally [13, 20, 31, 32] . keywords: care; emergency; infection; patients; precautions; tbp; transmission cache: cord-321837-0r86qxz1.txt plain text: cord-321837-0r86qxz1.txt item: #2096 of 2876 id: cord-321983-566pbuic author: Liu, Wei title: Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease date: 2020-02-28 words: 3809 flesch: 41 summary: We investigated factors affecting the outcomes of COVID-19 patients to evaluate the prognosis and further improve the treatment of patients with COVID-19 associated pneumonia with the hope of reducing mortality. This study aims to investigate the factors affecting the progression of pneumonia in COVID-19 patients. keywords: anti; covid-19; group; patients; pneumonia; progression cache: cord-321983-566pbuic.txt plain text: cord-321983-566pbuic.txt item: #2097 of 2876 id: cord-322009-0cwljo0c author: Ma, Ling title: Coinfection of SARS-CoV-2 and Other Respiratory Pathogens date: 2020-08-26 words: 3797 flesch: 36 summary: To differentiate between respiratory infections caused by SARS-CoV-2 and other respiratory pathogens during the COVID-19 outbreak in Wuhan, we simultaneously tested for SARS-CoV-2 and pathogens associated with CAP to determine the incidence and impact of respiratory coinfections in COVID-19 patients. Coinfections in COVID-19 patients are common. keywords: coinfection; cov-2; covid-19; group; pathogens; patients; sars; study cache: cord-322009-0cwljo0c.txt plain text: cord-322009-0cwljo0c.txt item: #2098 of 2876 id: cord-322052-zsbisk3b author: Bohórquez-Rivero, José title: Letter to the Editor: Humanization of Neurosurgery: Incorporation of a New Concept in Times of COVID-19 date: 2020-08-24 words: 1097 flesch: 36 summary: This attitude on the part of physicians can produce despair and provoke an emotional crisis in patients. Challenges neurosurgeons are facing include, among others, the advent of new technologies, an increasingly impersonal physician-patient relationship, loss of interest in the emotional aspects of the patient, differences in public versus private care, loss of autonomy to make decisions about patients, loss of interest in performing an adequate physical examination, and hospitals becoming increasingly less humanized. keywords: humanization; neurosurgery; patient cache: cord-322052-zsbisk3b.txt plain text: cord-322052-zsbisk3b.txt item: #2099 of 2876 id: cord-322054-whjisspt author: Zhang, S. title: Concerns about disease management and psychological stress in SAPHO patients during the COVID-19 epidemic date: 2020-05-11 words: 3485 flesch: 48 summary: As a group affected by the epidemic prevention and control measures, chronic disease patients are classified as level 4 population together with susceptible people and the public. However, considering the double impact of the epidemic on the physical and mental health of chronic disease patients, it is suggested that more attention should be paid to their psychological and medical care. keywords: covid-19; disease; epidemic; patients; preprint; sapho; syndrome cache: cord-322054-whjisspt.txt plain text: cord-322054-whjisspt.txt item: #2100 of 2876 id: cord-322063-96suqyfg author: Kampmeier, Stefanie title: A nosocomial cluster of vancomycin resistant enterococci among COVID-19 patients in an intensive care unit date: 2020-09-22 words: 2413 flesch: 35 summary: In recent years, the incidence of VRE infections has increased worldwide, including in Germany [11] . VRE infections are associated with significant mortality, in particular in patients with multiple co-morbidities and keywords: cluster; control; covid-19; infection; patients; samples; vancomycin; vre cache: cord-322063-96suqyfg.txt plain text: cord-322063-96suqyfg.txt item: #2101 of 2876 id: cord-322066-m8dphaml author: Kutscher, Eric title: Primary Care Providers: Discuss COVID-19-Related Goals of Care with Your Vulnerable Patients Now date: 2020-05-06 words: 804 flesch: 54 summary: Patients often require a prolonged intubation of 10-14 days, and patients who are older, have cardiovascular disease (including hypertension), diabetes, or malignancy have worse outcomes. Thus, in this time of medical crisis, we must step up to help patients better understand this pandemic. keywords: covid-19; patients cache: cord-322066-m8dphaml.txt plain text: cord-322066-m8dphaml.txt item: #2102 of 2876 id: cord-322102-4fi0y96f author: Zimmermann, Matthias title: Approaches to the management of patients in oral and maxillofacial surgery during COVID-19 pandemic date: 2020-04-04 words: 4695 flesch: 44 summary: When surgery is performed on COVID-19 patients, adequate personal protective equipment is crucial. In order to save resources and to avoid unnecessary exposure to infected patients, there is the need to schedule interventions depending on their priority. keywords: cov-2; covid-19; infection; patients; sars; surgery; transmission cache: cord-322102-4fi0y96f.txt plain text: cord-322102-4fi0y96f.txt item: #2103 of 2876 id: cord-322104-f1dukpso author: Niederman, M.S. title: PNEUMONIA | Community Acquired Pneumonia, Bacterial and Other Common Pathogens date: 2006-05-13 words: 10695 flesch: 32 summary: While most studies have focused on the in-hospital mortality of CAP, one recent evaluation of CAP patients over the age of 65 found that while the short-term risk (in-hospital mortality) of illness was an 11% death rate, the mortality rate at 1 year was over 40%, emphasizing that for many patients, CAP is a marker of underlying serious comorbidity, and a predictor of poor outcome, even after hospital discharge, for a variety of reasons. With these data in mind, new guidelines have suggested that CAP patients should not receive the same antibiotic as in the recent past, with a relatively arbitrary cutoff of defining this time interval as 'within the past 3 months'. keywords: cap; disease; factors; gram; illness; immune; infection; mortality; organisms; pathogens; patients; pneumonia; resistance; risk; therapy cache: cord-322104-f1dukpso.txt plain text: cord-322104-f1dukpso.txt item: #2104 of 2876 id: cord-322259-khknne8s author: de Roquetaillade, C. title: Unusual arterial thrombotic events in Covid-19 patients date: 2020-09-10 words: 1320 flesch: 41 summary: Arterial thrombotic events included acute coronary occlusions (n = 9), stroke (n = 6), limb ischemia (n = 3), splenic infarcts (n = 3), aortic thrombosis (n = 2) and occlusive mesenteric ischemia (n = 1). Reported arterial thrombotic events were acute coronary occlusions (n=9), stroke (n=6), limb ischemia (n=3), splenic infarcts (n=3), aortic thrombosis (n=2) activity tested in 2 patients was normal. keywords: arterial; covid-19; events; patients cache: cord-322259-khknne8s.txt plain text: cord-322259-khknne8s.txt item: #2105 of 2876 id: cord-322322-woz6lwdu author: Marcum, Michelle title: COVID‐19 pandemic and impact on cancer clinical trials: An academic medical center perspective date: 2020-07-10 words: 3156 flesch: 37 summary: key: cord-322322-woz6lwdu authors: Marcum, Michelle; Kurtzweil, Nicky; Vollmer, Christine; Schmid, Lisa; Vollmer, Ashley; Kastl, Alison; Acker, Kelly; Gulati, Shuchi; Grover, Punita; Herzog, Thomas J.; Ahmad, Syed A.; Sohal, Davendra; Wise‐Draper, Trisha M. title: COVID‐19 pandemic and impact on cancer clinical trials: An academic medical center perspective date: 2020-07-10 journal: Cancer Med DOI: 10.1002/cam4.3292 sha: doc_id: 322322 cord_uid: woz6lwdu The COVID‐19 pandemic changed health‐care operations around the world and has interrupted standard clinical practices as well as created clinical research challenges for cancer patients. In addition, the decision whether to continue cancer clinical trials became a safety concern regarding the treatment effect on cancer patients' vulnerability for COVID-19 contraction, potential viral exposure risk to clinical trial staff, and potential impact of an infected clinical trial cancer patient on study outcomes. keywords: cancer; covid-19; pandemic; patients; research; risk; study; treatment; trials cache: cord-322322-woz6lwdu.txt plain text: cord-322322-woz6lwdu.txt item: #2106 of 2876 id: cord-322394-b18fv3r3 author: Eichberg, Daniel G title: Telemedicine in Neurosurgery: Lessons Learned from a Systematic Review of the Literature for the COVID-19 Era and Beyond date: 2020-07-20 words: 4478 flesch: 34 summary: Another limitation is the complexity in comparing results of telemedicine studies within neurosurgical subspecialties. Evolving requirements for patient and physician safety and rapid regulatory changes have stimulated interest in neurosurgical telemedicine in the COVID-19 era. keywords: care; encounter; face; neurosurgery; patients; stroke; studies; study; telemedicine; total; visits cache: cord-322394-b18fv3r3.txt plain text: cord-322394-b18fv3r3.txt item: #2107 of 2876 id: cord-322439-86dojc70 author: Celarier, Thomas title: Covid-19: Adapting the geriatric organisations to respond to the pandemic date: 2020-06-11 words: 1396 flesch: 42 summary: Also, deaths in nursing homes account for almost 40% of all deaths (1), while nursing homes residents represent only 1% of the French population (2) . Associated with this new organization, mobile teams propose medical care to nursing home patients at their places of residence and, if necessary, in coordination with the palliative care and/or home hospitalization teams (16, 17) . keywords: covid-19; hospital; nursing; patients cache: cord-322439-86dojc70.txt plain text: cord-322439-86dojc70.txt item: #2108 of 2876 id: cord-322448-s04e6po9 author: Gadsby, Naomi J. title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia date: 2016-04-01 words: 4378 flesch: 30 summary: Comprehensive molecular testing of single lower respiratory tract (LRT) specimens achieved pathogen detection in 87% of CAP patients compared with 39% with culture-based methods. One limitation of our study was that it was restricted to CAP patients who could produce a sputum specimen. keywords: bacterial; cap; community; culture; detection; patients; pcr; pneumonia; specimens; time cache: cord-322448-s04e6po9.txt plain text: cord-322448-s04e6po9.txt item: #2109 of 2876 id: cord-322497-hdy3va8e author: LUBANSU, Alphonse title: COVID-19 impact on neurosurgical practice: lockdown attitude and experience of a European academic center. date: 2020-09-03 words: 1166 flesch: 38 summary: limited clinical neurosurgical experience including COVID-19 patients have been reported. The mortality rate of COVID-19 patients was remarkably high (45%), and even higher in patients that underwent surgical intervention (77 %). keywords: covid-19; infection; patients; test cache: cord-322497-hdy3va8e.txt plain text: cord-322497-hdy3va8e.txt item: #2110 of 2876 id: cord-322534-eikz07zz author: Allahyari, Abolghasem title: Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trial date: 2020-06-26 words: 1251 flesch: 49 summary: Patients with acute lymphoid and myeloid leukemias in the first line treated with curative intent, patients with high-grade non-Hodgkin's lymphoma treated with leukemia protocols and patients with non-metastatic breast and colon cancer in the first line of treatment will enter the study. key: cord-322534-eikz07zz authors: Allahyari, Abolghasem; Rahimi, Hossein; Khadem-Rezaiyan, Majid; Mozaheb, Zahra; Seddigh-Shamsi, Mohsen; Bary, Alireza; Kamandi, Mostafa; Azimi, Sajad Ataei; HasanAbadi, Saeed Eslami; Noferesti, Alireza; Shariatmaghani, Somayeh Sadat; Rafatpanah, Houshang; Khatami, Shohreh; Imani, Afshin Jabbar; Mortazi, Hassan; Nodeh, Mohammad Moeini title: Effect of hydroxychloroquine on COVID-19 prevention in cancer patients undergoing treatment: a structured summary of a study protocol for a randomised controlled trial date: 2020-06-26 journal: Trials DOI: 10.1186/s13063-020-04485-x sha: doc_id: 322534 cord_uid: eikz07zz OBJECTIVES: keywords: covid-19; patients; protocol; trial cache: cord-322534-eikz07zz.txt plain text: cord-322534-eikz07zz.txt item: #2111 of 2876 id: cord-322552-95bj65qf author: Sang, Charlie Joseph title: ST Elevations in the Era of COVID-19 date: 2020-08-06 words: 2657 flesch: 37 summary: This scenario also raises important questions in the management of COVID-19 patients with ST elevation myocardial infarction in the United States, where percutaneous coronary intervention (PCI) is the standard of care. The use of ticagrelor in the setting of COVID-19 myocardial infarction requires further attention. keywords: acute; coronary; covid-19; disease; myocardial; myopericarditis; patients cache: cord-322552-95bj65qf.txt plain text: cord-322552-95bj65qf.txt item: #2112 of 2876 id: cord-322590-twnlaq24 author: Hoyer, Carolin title: Changes in Demographic and Diagnostic Spectra of Patients with Neurological Symptoms Presenting to an Emergency Department During the COVID-19 Pandemic: A Retrospective Cohort Study date: 2020-09-30 words: 3057 flesch: 34 summary: The year 2017 was chosen because data from ED patients of that year were fully and readily available, allowing for a rapid and timely comparative analysis with the COVID-19 epoch in 2020. In calendar week 1-15 of 2017, a total of 1511 patients presented with neurological symptoms to the ED, while in calendar weeks 1-15 of 2020, there were 1403 neurological ED patients. keywords: care; covid-19; department; emergency; pandemic; patients; weeks cache: cord-322590-twnlaq24.txt plain text: cord-322590-twnlaq24.txt item: #2113 of 2876 id: cord-322663-a58e6pp8 author: Giacomelli, Andrea title: 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: a prospective cohort study date: 2020-05-22 words: 3165 flesch: 43 summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges WHO Director-General's opening remarks at the media briefing on COVID-19 -11 Clinical features of patients infected with 2019 novel coronavirus in Wuhan A Novel Coronavirus from Patients with Pneumonia in China Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: COVID-19: the gendered impacts of the outbreak Kidney disease is associated with in-hospital death of patients with COVID-19 Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Clinical Characteristics of Coronavirus Disease 2019 in China Analysis of Epidemiological and Clinical features in older patients with Corona Virus Disease keywords: admission; covid-19; death; disease; epidemic; patients; study cache: cord-322663-a58e6pp8.txt plain text: cord-322663-a58e6pp8.txt item: #2114 of 2876 id: cord-322746-28igib4l author: Gosche, John R. title: Acute, subacute, and chronic cervical lymphadenitis in children date: 2007-06-06 words: 4727 flesch: 31 summary: The symptoms associated with acute cervical lymphadenitis reflect these pathophysiologic events. Laboratory tests are seldom required as part of the workup for acute cervical lymphadenitis. keywords: children; disease; infections; lymphadenitis; lymphadenopathy; nodal; nodes; patients; skin; therapy cache: cord-322746-28igib4l.txt plain text: cord-322746-28igib4l.txt item: #2115 of 2876 id: cord-322799-opf1qwgl author: Hiremath, Channabasavaraj Shivalingaiah title: IACTS guidelines: practice of cardiovascular and thoracic surgery in the COVID-19 era date: 2020-08-11 words: 3944 flesch: 47 summary: There is a proven increased risk in morbidity and mortality in COVID-19 patients undergoing cardiac surgery [13] . Deferring care to such patients can aggravate risk and potentially turn fatal. keywords: cardiac; care; cases; covid-19; guidelines; health; patient; risk; surgery; swab; use cache: cord-322799-opf1qwgl.txt plain text: cord-322799-opf1qwgl.txt item: #2116 of 2876 id: cord-322861-q7uk6rdp author: Zanon, Ezio title: How haemophilia A impacts severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) treatment: a case report date: 2020-07-16 words: 2118 flesch: 40 summary: Even if much more data are needed to ascertain the real thrombotic risk of haemophilia A in COVID-19 patients, it’s clear that the FVIII and vWF should be strictly monitored in order to promptly establish an adequate treatment and avoid the onset of thromboembolic events, even fatal, causing many deaths in COVID-19 patients. In addition to respiratory complications, several changes in the coagulation processes have been observed in COVID-19 patients such as elevated D-dimer, reduced platelet count, disseminated intravascular coagulation (DIC), thrombotic microangiopathies (2, 3) . keywords: coagulation; covid-19; haemophilia; levels; n.v; patient cache: cord-322861-q7uk6rdp.txt plain text: cord-322861-q7uk6rdp.txt item: #2117 of 2876 id: cord-322867-1yxxe5d3 author: Hartman, William R title: Hospitalized COVID-19 Patients treated with Convalescent Plasma in a Mid-size City in the Midwest date: 2020-07-14 words: 2902 flesch: 44 summary: (8-10) We describe our experience treating a series of COVID-19 patients with severe or life-threatening disease with convalescent plasma. Our results are consistent with other early reports of outcomes in COVID-19 patients transfused with convalescent plasma. keywords: convalescent; covid-19; disease; life; patients; plasma cache: cord-322867-1yxxe5d3.txt plain text: cord-322867-1yxxe5d3.txt item: #2118 of 2876 id: cord-322868-o3r0y6bz author: Williams, E. J. title: Routine measurement of serum procalcitonin allows antibiotics to be safely withheld in patients admitted to hospital with SARS-CoV-2 infection. date: 2020-07-02 words: 2833 flesch: 37 summary: STHNFT guidelines recommended that antibiotics could be withheld in COVID-19 patients with a PCT value of ≤ 0.25ng/ml unless felt necessary by a senior clinician, as concomitant bacterial infection is unlikely in such patients [19] . It is possible that some patients may have been readmitted to other regional hospitals, but this is felt unlikely as the Treatment of Community-Acquired Pneumonia During the Coronavirus Disease 2019 (COVID-19) Pandemic Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis Impact of Procalcitonin-Guided Antibiotic Management on Antibiotic Exposure and Outcomes: Real-world Evidence Improved sensitivity using a dual target, E and RdRp assay for the diagnosis of SARS-CoV-2 infection: Experience at a large NHS Foundation Trust in the UK Effectiveness of a procalcitonin algorithm to guide antibiotic therapy in respiratory tract infections outside of study conditions: a post-study survey Metrics for quantifying antibiotic use in the hospital setting: results from a systematic review and international multidisciplinary consensus procedure Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: clusterrandomised, single-blinded intervention trial Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial Assessment of Procalcitonin as a Diagnostic Marker of Underlying Infection in Patients with Febrile Neutropenia Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein Procalcitonin and Proinflammatory Cytokine Clearance during Continuous Venovenous Haemofiltration in Septic Patients keywords: antibiotics; covid-19; infection; negative; patients; pct; procalcitonin cache: cord-322868-o3r0y6bz.txt plain text: cord-322868-o3r0y6bz.txt item: #2119 of 2876 id: cord-322893-av8hj005 author: MacKoul, Paul title: Laparoscopic-assisted myomectomy with uterine artery occlusion at a freestanding ambulatory surgery center: a case series date: 2020-06-16 words: 4551 flesch: 38 summary: Received: 17 January 2020 Accepted: 2 June 2020 Uterine myomas: an overview of development, clinical features, and management The frequency of uterine leiomyomas Myomectomy: technique and current indications Hysteroscopic morcellation of submucous myomas: a systematic review Comparison of robotic, laparoscopic, and abdominal myomectomy in a community hospital Comparative study between robotic laparoscopic myomectomy and abdominal myomectomy Roboticassisted laparoscopic myomectomy compared with standard laparoscopic myomectomy: a retrospective matched control study Laparoscopically assisted myomectomy: a report of a new technique in 57 cases Laparoscopically assisted myomectomy versus abdominal myomectomy in short-term outcomes: a prospective study Laparoscopy vs laparoscopically assisted myomectomy in the management of uterine myomas: a prospective study Recurrence of uterine myoma after myomectomy: open myomectomy versus laparoscopic myomectomy Laparoscopic-assisted myomectomy with bilateral uterine artery occlusion/ligation May-Jun) Hemostatic techniques for myomectomy: an evidence-based approach Combined laparoscopic uterine artery occlusion and myomectomy versus laparoscopic myomectomy: a direct-comparison meta-analysis of short-and long term outcomes in women with symptomatic leiomyomas Are morbidly obese patients suitable for ambulatory surgery? The patients were further grouped into three categories based on BMI: non-obese patients (BMI < 30 kg/m 2 ), obese patients (BMI > 30 and < 40 kg/m 2 ), and morbidly obese patients (BMI >40 kg/m 2 ), and the comorbidities and surgical outcomes of each group were compared. keywords: artery; blood; bmi; lam; laparoscopic; myomectomy; obese; patients; surgery cache: cord-322893-av8hj005.txt plain text: cord-322893-av8hj005.txt item: #2120 of 2876 id: cord-322957-clf8f90t author: Crespo, Javier title: Resumption of activity in gastroenterology departments. Recommendations by SEPD, AEEH, GETECCU and AEG date: 2020-04-28 words: 5301 flesch: 46 summary: General recommendations regarding the treatment of patients with IBD, which must remain in force during the gradual resumption of activities: a. Patients must not discontinue medication or visits to the infusion center, or start self-medication, without consulting with their doctor first. A possible reason explaining this lower number of cases of COVID-19 in IBD patients may be this population's adherence to protective measures. keywords: activity; care; cov-2; covid-19; disease; ibd; infection; pandemic; patients; phase; recommendations; risk; sars cache: cord-322957-clf8f90t.txt plain text: cord-322957-clf8f90t.txt item: #2121 of 2876 id: cord-322990-q07yy5k8 author: Garutti, Mattia title: Seven Shades of Black Thoughts: COVID-19 and Its Psychological Consequences on Cancer Patients date: 2020-07-10 words: 2206 flesch: 44 summary: COVID-19 is plaguing people not only physically but also psychologically, and cancer patients are particularly exposed to this emotional threat. Herein, we describe the psychological threats posed by COVID-19 to cancer patients. keywords: cancer; care; covid-19; loneliness; patients; support cache: cord-322990-q07yy5k8.txt plain text: cord-322990-q07yy5k8.txt item: #2122 of 2876 id: cord-323024-blc3mnbj author: Bernard-Valnet, R. title: CSF of SARS-CoV-2 patients with neurological syndromes reveals hints to understand pathophysiology date: 2020-11-04 words: 3506 flesch: 42 summary: The presence of SARS-CoV-2 antibodies was explained by a rupture of the blood brain barrier (passive transfer) in 6/16 (37,5%), but an intrathecal synthesis of SARS-CoV2-specific antibodies was present in 2/17.As compared to SARS-CoV-2-negative NIND patients, the CSF of IND patients exhibited the highest level of chemokines (CCL4, CCL5, CXCL8, CXCL10, CXCL12, and CXCL13), followed the CSF of MS patients (CXCL12, and CXCL13). There was no difference between COVID-19 patients with neurological diseases compared to NIND even if some chemokines (CCL4, CCL5, CXCL8, andCXCL10) tended to be higher than NIND. keywords: antibodies; brain; cov-2; covid-19; csf; patients; preprint; sars cache: cord-323024-blc3mnbj.txt plain text: cord-323024-blc3mnbj.txt item: #2123 of 2876 id: cord-323092-j2u0ny2u author: Crosby, James C. title: COVID‐19: A review of therapeutics under investigation date: 2020-04-19 words: 3905 flesch: 44 summary: There is another single ongoing observational trial examining the efficacy of anti-SARS-CoV-2 inactivated convalescent plasma in COVID-19 patients, the results of which remain to be seen. Some anecdotal evidence is emerging regarding its use in COVID-19 patients. keywords: chloroquine; convalescent; coronavirus; cov-2; covid-19; disease; patients; plasma; sars; treatment; use cache: cord-323092-j2u0ny2u.txt plain text: cord-323092-j2u0ny2u.txt item: #2124 of 2876 id: cord-323133-gdg50omp author: Buzatto, G. P. title: The pathogens profile in children with otitis media with effusion and adenoid hypertrophy date: 2017-02-23 words: 4245 flesch: 36 summary: S. pneumoniae and M. catarrhalis were detected more often in middle ear washes from OME patients than controls. Although total virus detection was not statistically different from controls at the middle ear washes (p = 0.065), adenovirus was detected in higher proportions in adenoid samples of OME patients than controls (p = 0.019). keywords: adenoid; bacteria; children; detection; ear; media; middle; ome; otitis; patients cache: cord-323133-gdg50omp.txt plain text: cord-323133-gdg50omp.txt item: #2125 of 2876 id: cord-323180-3ih0i81s author: Pardo, Emmanuel title: Nutritional support for critically ill patients with COVID-19: New strategy for a new disease? date: 2020-10-12 words: 1079 flesch: 35 summary: Expert groups suggest starting, in high risk patients, at 25% of caloric target, regardless of nutrition route, and increasing slowly while closely monitoring serum phosphate, magnesium and potassium, especially during the first 72 hours of ICU stay. In case of formal contraindication to EN or severe feeding intolerance, refractory to prokinetic treatment or post-pyloric tube, total parenteral nutrition should be introduced either early in malnourished patients or at day 4-7 in low nutritional risk patients. keywords: covid-19; icu; nutrition; patients cache: cord-323180-3ih0i81s.txt plain text: cord-323180-3ih0i81s.txt item: #2126 of 2876 id: cord-323225-ou7pppum author: Mondal, R. N. title: Socio-demographic, clinical, hospital admission and oxygen requirement characteristics of COVID-19 patients of Bangladesh date: 2020-08-16 words: 3353 flesch: 56 summary: key: cord-323225-ou7pppum authors: Mondal, R. N.; Razzak Sarker, M. A.; Das, A.; Ahsan, M. A. K.; Jahan, S. M. S.; Sultana, A.; Sultana, J.; Rani, M. title: Socio-demographic, clinical, hospital admission and oxygen requirement characteristics of COVID-19 patients of Bangladesh date: 2020-08-16 journal: nan DOI: 10.1101/2020.08.14.20175018 sha: doc_id: 323225 cord_uid: ou7pppum Abstract Background: Clinical presentation hospital admission and outcome of COVID-19 pandemic are different from one country to another. Conclusion: COVID-19 patients were mostly male health worker. keywords: covid-19; hospital; license; medrxiv; patients; preprint; study; symptoms cache: cord-323225-ou7pppum.txt plain text: cord-323225-ou7pppum.txt item: #2127 of 2876 id: cord-323255-elwfiima author: Huijskens, E. G. W. title: Evaluation of Patients with Community‐Acquired Pneumonia Caused by Zoonotic Pathogens in an Area with a High Density of Animal Farms date: 2015-07-27 words: 3778 flesch: 45 summary: We evaluated patients with community‐acquired pneumonia (CAP) with known and unknown aetiology in an area with a high livestock density and a potential association with animal farms in the proximity. The presence and number of farm animals within 1 km of the patients' home address were assessed using geographic information system (GIS) and were compared between cases and age‐matched control subjects. keywords: animal; burnetii; cap; number; patients; presence cache: cord-323255-elwfiima.txt plain text: cord-323255-elwfiima.txt item: #2128 of 2876 id: cord-323273-q53wf6au author: Olivia Li, Ji-Peng title: Digital technology, tele-medicine and artificial intelligence in ophthalmology: A global perspective date: 2020-09-06 words: 13440 flesch: 23 summary: The 1640 foundation of this integration project enabled the safe delivery of eye care services 1641 during the COVID-19 pandemic with many primary and urgent eye care services 1642 enabling non-hospital patient care (NHS Scotland 2020). Can we predict the future growth of demand on UK Eye 2491 Care Services? Optical coherence tomography machine learning 2494 classifiers for glaucoma detection: a preliminary study Automated Grading of Age-Related Macular Degeneration From Color Fundus 2498 Images Using Deep Convolutional Neural Networks Expert Diagnosis of Plus Disease in Retinopathy of Prematurity From 2505 Computer-Based Image Analysis A telemedicine program for diabetic retinopathy in a Veterans 2509 Joslin Vision Network Eye Health Care Model MEDICARE TELEMEDICINE HEALTH 2512 CARE PROVIDER FACT SHEET Automated Detection of Glaucoma From Topographic Features of 2516 the Optic Nerve Head in Color Fundus Photographs Comparison of machine learning and traditional classifiers in glaucoma 2520 diagnosis Healthy China 2030: moving from blueprint to action 2522 with a new focus on public health Characteristics of severe retinopathy of prematurity patients in 2524 China: a repeat of the first epidemic? Gene expression inference 2526 with deep learning 2528 'Peripapillary atrophy detection by sparse biologically inspired feature manifold Artificial 2531 Intelligence in Diabetic Eye Disease Screening EFFECTIVENESS OF DIFFERENT MONITORING MODALITIES IN THE 2535 DETECTION OF NEOVASCULAR AGE-RELATED MACULAR 2536 DEGENERATION: keywords: age; care; covid-19; data; deep; degeneration; detection; diabetic; diagnosis; digital; disease; eye; fundus; glaucoma; health; healthcare; learning; ophthalmology; patients; prematurity; retinopathy; screening; services; study; telemedicine; use; visual cache: cord-323273-q53wf6au.txt plain text: cord-323273-q53wf6au.txt item: #2129 of 2876 id: cord-323293-4gmnkg09 author: Sobhani, Navid title: Mutant p53 as an Antigen in Cancer Immunotherapy date: 2020-06-08 words: 8079 flesch: 45 summary: To corroborate such a possibility, a recent study showed that a T cell receptor-like (TCLR) antibody, initially made for a wild-type antigen, was capable of discriminating between mutant p53 and wild-type p53, specifically killing more cancer cells expressing mutant p53 than wild-type p53 in vitro and inhibiting the tumour growth of mice injected with mutant p53 cancer cells than mice with wild-type p53 cancer cells. The p53 protein is an unusually shaped tetramer that binds directly to DNA TP53 mutations in human cancers: origins, consequences, and clinical use Gain of function mutations in p53 p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM A common gain of function of p53 cancer mutants in inducing genetic instability Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis Mutant p53R270H gain of function phenotype in a mouse model for oncogene-induced mammary carcinogenesis Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53 TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73 A Subset of Tumor-Derived Mutant Forms of p53 Down-Regulate p63 and p73 through a Direct Interaction with the p53 Core Domain Regulators of oncogenic mutant TP53 gain of function. keywords: abs; antibodies; cancer; carcinoma; cells; immune; mut; mutant; p53; patients; protein; serum; studies; tumor cache: cord-323293-4gmnkg09.txt plain text: cord-323293-4gmnkg09.txt item: #2130 of 2876 id: cord-323314-y3k9dntf author: Aggarwal, Sandeep title: Obesity and Metabolic Surgery Society of India (OSSI) Recommendations for Bariatric and Metabolic Surgery Practice During the COVID-19 Pandemic date: 2020-08-22 words: 2792 flesch: 43 summary: Obes Surg The impact of COVID-19 pandemic on obesity and bariatric surgery Safer through surgery: American Society for Metabolic and Bariatric Surgery statement regarding metabolic and bariatric surgery during the COVID-19 pandemic Recommendations for metabolic and bariatric surgery during the COVID-19 pandemic from IFSO Joint Statement: roadmap for resuming elective surgery after COVID-19 pandemic SAGES and EAES recommendations for minimally invasive surgery during COVID-19 pandemic Surgical practice recommendations for minimal access surgeons during COVID 19 pandemic-Indian inter society directives Bariatric surgical practice during the initial phase of COVID-19 outbreak Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery A structured approach for safely reintroducing bariatric surgery in a COVID-19 environment published online ahead of print Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Conversion of operating theatre from positive to negative pressure environment Surgery in COVID-19 patients: operational directives Consensus guidelines for managing the airway in patients with COVID −19: guidelines from the Difficult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetists COVID operation theatre-advisory and position statement of Indian Society of Anaesthesiologists COVID-19 & the general surgical department-measures to reduce spread of SARS-COV-2 among surgeons Detecting hepatitis B virus in surgical smoke emitted during laparoscopic surgery Is there a role for ERAS program implementation to restart bariatric surgery after the peak of COVID-19 pandemic? Recommendations for surgery during the novel coronavirus (COVID-19) epidemic Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations In view of the above and considering obesity and bariatric surgery to be of equal importance as other chronic lifethreatening diseases and cancer, the Obesity and Metabolic Surgery Society of India (OSSI) decided to frame recommendations which will help bariatric surgeons to prepare for the possible recommencement of bariatric surgery in the near future. keywords: bms; covid-19; obesity; pandemic; patients; recommendations; risk; surgery cache: cord-323314-y3k9dntf.txt plain text: cord-323314-y3k9dntf.txt item: #2131 of 2876 id: cord-323446-w2ci1bfr author: Pan, Feng title: Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia date: 2020-02-13 words: 2830 flesch: 52 summary: Based on quartiles of patients from day 0 to day 26 involvement, 4 stages of lung CT were defined: Stage 1 (0-4 days): ground glass opacities (GGO) in 18/24 (75%) patients with the total CT score of 2±2; (2)Stage-2 (5-8d days): increased crazy-paving pattern 9/17 patients (53%) with a increase in total CT score (6±4, p=0.002); (3) Stage-3 (9-13days): consolidation 19/21 (91%) patients with the peak of total CT score (7±4); (4) Stage-4 (≥14 days): gradual resolution of consolidation 15/20 (75%) patients with a decreased total CT score (6±4) without crazy-paving pattern. keywords: covid-19; days; patients; pneumonia; total cache: cord-323446-w2ci1bfr.txt plain text: cord-323446-w2ci1bfr.txt item: #2132 of 2876 id: cord-323463-osf6t7cw author: Cercenado, Emilia title: Update on bacterial pathogens: virulence and resistance date: 2008-04-30 words: 15034 flesch: 38 summary: CA-MRSA infections refer to MRSA infections in patients lacking established MRSA risk factors and without a previous history of MRSA infection or colonization: they do not have a medical history in the past year of hospitalization, healthcare-related admission (to a nursing home, skilled nursing facility or hospice), dialysis, surgery, or implantation of a permanent indwelling catheter or other medical devices 8, 14 . However, there is now an increasing number of reports of MRSA infections in the community that have not escaped from the hospitals, and no longer can MRSA be considered as an exclusively nosocomial pathogen. keywords: aureus; authors; cases; children; community; control; disease; hospital; incidence; infections; isolates; mrsa; patients; pertussis; resistance; samples; staphylococcus; strains; study; treatment; use; vaccination; vaccine; vancomycin cache: cord-323463-osf6t7cw.txt plain text: cord-323463-osf6t7cw.txt item: #2133 of 2876 id: cord-323470-lpeeugdf author: Ates, Omer Faruk title: Thorax magnetic resonance imaging findings in patients with coronavirus disease (COVID-19) date: 2020-08-15 words: 3331 flesch: 47 summary: One of the disadvantages of MRI in pneumonia patients is imaging time and artifacts. In this study, similar to our study, a perfect match was found between MRI findings and CT findings. keywords: covid-19; imaging; mri; patients; pneumonia; study cache: cord-323470-lpeeugdf.txt plain text: cord-323470-lpeeugdf.txt item: #2134 of 2876 id: cord-323489-ro7kbnu3 author: Arenas, María Dolores title: Protection of nephrology health professionals during the COVID-19 pandemic date: 2020-10-06 words: 4139 flesch: 39 summary: This exposure can result from contact with other patients or with co-workers. There are a number of reasons why the protection of healthcare professionals has to be one of the main objectives in the SARS-CoV-2 pandemic: 1) They are necessary to guarantee the continuity of care; 2) They have a high risk of contagion due to their front-line exposure to infected patients; and 3) keywords: coronavirus; covid-19; equipment; healthcare; hospital; patients; professionals; risk; staff cache: cord-323489-ro7kbnu3.txt plain text: cord-323489-ro7kbnu3.txt item: #2135 of 2876 id: cord-323538-9dlr6kqh author: Malard, Florent title: COVID-19 outcomes in patients with hematologic disease date: 2020-05-06 words: 1604 flesch: 41 summary: We observed an overrepresentation of patients with MM in our cohort (although MM is not overrepresented in our department), suggesting that such patients are particularly vulnerable, owning to the immunosuppression associated with the disease and its treatment, in particular steroids. key: cord-323538-9dlr6kqh authors: Malard, Florent; Genthon, Alexis; Brissot, Eolia; van de Wyngaert, Zoe; Marjanovic, Zora; Ikhlef, Souhila; Banet, Anne; Lapusan, Simona; Sestilli, Simona; Corre, Elise; Paviglianiti, Annalisa; Adaeva, Rosa; M.’Hammedi-Bouzina, Fella; Labopin, Myriam; Legrand, Ollivier; Dulery, Rémy; Mohty, Mohamad title: COVID-19 outcomes in patients with hematologic disease date: 2020-05-06 journal: keywords: covid-19; hematologic; infection; patients cache: cord-323538-9dlr6kqh.txt plain text: cord-323538-9dlr6kqh.txt item: #2136 of 2876 id: cord-323582-7y8pt72r author: Ahamad, Martuza title: A Machine Learning Model to Identify Early Stage Symptoms of SARS-Cov-2 Infected Patients date: 2020-06-20 words: 4458 flesch: 51 summary: • Identification of the significant symptoms of COVID-19 patients by analyzing their association using five different machine learning approaches. We calculated the coefficient values for each feature that are significant for COVID-19 patients. keywords: accuracy; age; covid-19; data; features; infection; machine; patients; symptoms cache: cord-323582-7y8pt72r.txt plain text: cord-323582-7y8pt72r.txt item: #2137 of 2876 id: cord-323647-q67fa0m3 author: Misra, Durga Prasanna title: Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates date: 2020-09-02 words: 6153 flesch: 32 summary: In this French RCT (the BBQ trial), patients with recurrent pregnancy loss shall be treated with HCQ 400 mg daily or placebo starting pre-conception until the 10 th week of pregnancy, with the objective of assessing whether treatment improves pregnancy outcomes in such patients [18] . THerapy in ST-Segment Elevation MYocardial InfarctionS: a randomized double-blind, placebocontrolled trial (TETHYS Trial) Low-dose methotrexate for the prevention of atherosclerotic events Colchicine as an anti-inflammatory and cardioprotective agent Colchicine revisited The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation Colchicine improves survival, left ventricular remodeling, and chronic cardiac function after acute myocardial infarction Effects of colchicine on atherosclerotic plaque stabilization: a multimodality imaging study in an animal model Colchicine reduces platelet aggregation by modulating cytoskeleton rearrangement via inhibition of cofilin and LIM domain kinase 1 Can the thiol/disulfide imbalance be a predictor of colchicine resistance in familial mediterranean fever? Colchicine therapy and plaque stabilization in patients with acute coronary syndrome: a CT coronary angiography study Effect of shortterm colchicine treatment on endothelial function in patients with coronary artery disease Colchicine as a novel therapy for suppressing chemokine production in patients with an acute coronary syndrome: a pilot study The Low Dose Colchicine after Myocardial Infarction (LoDoCo-MI) study: a pilot randomized placebo controlled trial of colchicine following acute myocardial infarction The effect of low-dose colchicine in patients with stable coronary artery disease: the LoDoCo2 trial rationale, design, and baseline characteristics COLIN trial: value of colchicine in the treatment of patients with acute myocardial infarction and inflammatory response Efficacy and safety of low-dose colchicine after myocardial infarction Role of colchicine in stroke prevention: an updated meta-analysis The role of colchicine in treating postoperative and post-catheter ablation atrial fibrillation Comparative transcriptome analysis to elucidate the therapeutic mechanism of colchicine against atrial fibrillation The effect of colchicine on the echocardiographic constrictive physiology after coronary artery bypass graft surgery Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys Effectiveness of colchicine therapy in 4 cases of retroperitoneal fibrosis associated with autoinflammatory diseases Use of colchicine to prevent recurrence of ear keloids. keywords: colchicine; covid-19; disease; drugs; effects; hcq; hydroxychloroquine; methotrexate; patients; placebo; risk; treatment; trial cache: cord-323647-q67fa0m3.txt plain text: cord-323647-q67fa0m3.txt item: #2138 of 2876 id: cord-323705-n2rec4i8 author: Varatharaj, Aravinthan title: Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study date: 2020-06-25 words: 5255 flesch: 31 summary: These complications are relatively uncommon, but such patients are often the most severely affected, neces sitating protracted intensive care admis sion and often resulting in poor outcomes. Neurologic manifestations of hospitalized patients with coronavirus disease Olfactory and gustatory dysfunctions as a clinical presentation of mildto moderate forms of the coronavirus disease (COVID19): a multicenter European study Selfreported olfactory and taste disorders in SARSCoV2 patients: a crosssectional study A first case of meningitis/ encephalitis associated with SARSCoronavirus2 COVID19associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features Neurological associations of COVID19 Neurological manifestations of influenza infection in children and adults: results of a National British Surveillance Study Neurological complications during treatment of Middle East respiratory syndrome Coagulation disorders in coronavirus infected patients: COVID19, SARSCoV1, MERSCoV and lessons from the past Psychiatric and neuropsychiatric presentations associated with severe coronavirus infection: a systematic review and metaanalysis with comparison to the COVID19 pandemic Neurologic features in severe SARSCoV2 infection The Association of British Neurologists The British Association of Stroke Physicians. keywords: acute; cases; clinical; complications; covid19; data; health; infection; patients; psychiatric; status; stroke; study cache: cord-323705-n2rec4i8.txt plain text: cord-323705-n2rec4i8.txt item: #2139 of 2876 id: cord-323713-bc00vths author: Volpi, Stefano title: Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome date: 2019-05-29 words: 3228 flesch: 40 summary: Monitoring of peripheral blood type I interferon signature during ruxolitinib treatment did not show a stable decrease. During three years of ruxolitinib treatment, P1 presented three flares of the skin lesions requiring brief cycles of steroids. keywords: age; disease; fig; ifn; lung; patients; ruxolitinib; savi; table; treatment; type cache: cord-323713-bc00vths.txt plain text: cord-323713-bc00vths.txt item: #2140 of 2876 id: cord-323761-9m177ozm author: Wang, Huijie title: Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety date: 2020-02-22 words: 6840 flesch: 37 summary: In a systematic review of 13 randomized-placebo controlled trials, the use of anticholinergic tiotropium ameliorates asthma control in patients with moderate symptomatic asthma who have already received medium-to-high doses ICS or ICS/LABA [44] , while there are few studies on the use of anticholinergics in asthma patients during pregnancy. It is generally believed that one-third of asthma patients are aggravated due to pregnancy, and most occur in the middle of pregnancy; one-third improved, and no significant changes are observed in the remaining 1/3 of patients. keywords: asthma; control; effects; ics; outcomes; patients; pregnancy; risk; studies; study; treatment; use; women cache: cord-323761-9m177ozm.txt plain text: cord-323761-9m177ozm.txt item: #2141 of 2876 id: cord-323787-9lq8rkih author: Bösch, Florian title: Attenuated early inflammatory response in solid organ recipients with COVID‐19 date: 2020-06-26 words: 1677 flesch: 45 summary: Thus, it can be assumed that transplant patients under immunosuppression and plagued with numerous comorbidities are at particular risk for an unfavorable course of COVID-19. key: cord-323787-9lq8rkih authors: Bösch, Florian; Börner, Nikolaus; Kemmner, Stephan; Lampert, Christopher; Jacob, Sven; Koliogiannis, Dionysios; Stangl, Manfred; Michel, Sebastian; Kneidinger, Nikolaus; Schneider, Christian; Fischereder, Michael; Irlbeck, Michael; Denk, Gerald; Werner, Jens; Angele, Martin K.; Guba, Markus O. title: Attenuated early inflammatory response in solid organ recipients with COVID‐19 date: 2020-06-26 journal: Clin Transplant DOI: 10.1111/ctr.14027 sha: doc_id: 323787 cord_uid: 9lq8rkih Immunosuppression leaves transplanted patients at particular risk for severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection. keywords: covid-19; immunosuppression; patients; transplant cache: cord-323787-9lq8rkih.txt plain text: cord-323787-9lq8rkih.txt item: #2142 of 2876 id: cord-323809-bocidwg4 author: Patel, Dhwanil title: COVID-19 EXTRAPULMONARY ILLNESS - The Impact of COVID-19 on Nephrology Care date: 2020-07-25 words: 3421 flesch: 40 summary: All these risk factors are commonly found in patients with CKD and hence in kidney transplant patients. A small preprint study from a Chinese dialysis unit suggested the course may be milder in dialysis patients compared to other patient cohorts [26] keywords: acute; aki; covid-19; dialysis; disease; kidney; patients; transplant cache: cord-323809-bocidwg4.txt plain text: cord-323809-bocidwg4.txt item: #2143 of 2876 id: cord-323816-3m1iu9j2 author: Singh, Awadhesh Kumar title: Impact of COVID-19 and comorbidities on health and economics: Focus on developing countries and India date: 2020-08-27 words: 2694 flesch: 35 summary: Despite the huge number of COVID-19 patients, India still has low volume research at the moment. A similar finding of disproportionately higher asymptomatic (46.3%) COVID-19 patients were also observed from Kuwait keywords: comorbidities; countries; covid-19; diabetes; india; mortality; patients cache: cord-323816-3m1iu9j2.txt plain text: cord-323816-3m1iu9j2.txt item: #2144 of 2876 id: cord-323831-1qadv7r1 author: Coleman, H title: Severe acute respiratory syndrome coronavirus-2 in post-laryngectomy patients: case series of four patients date: 2020-06-23 words: 2004 flesch: 48 summary: key: cord-323831-1qadv7r1 authors: Coleman, H; Sutherland, J; Calder, N title: Severe acute respiratory syndrome coronavirus-2 in post-laryngectomy patients: case series of four patients date: 2020-06-23 journal: The Journal of laryngology and otology DOI: 10.1017/s0022215120001310 sha: doc_id: 323831 cord_uid: 1qadv7r1 OBJECTIVE: To report our experience of diagnosis, investigation and management in patients who had undergone laryngectomy secondary to previous squamous cell carcinoma, who were subsequently infected with severe acute respiratory syndrome coronavirus-2 during the coronavirus disease 2019 pandemic. This study focuses on post-laryngectomy patients admitted with SARS-CoV-2 infection during the outbreak peak (1 March to 1 May 2020) • keywords: cov-2; laryngectomy; patient; sars cache: cord-323831-1qadv7r1.txt plain text: cord-323831-1qadv7r1.txt item: #2145 of 2876 id: cord-323906-ro078y52 author: Sardu, Celestino title: Implications of AB0 blood group in hypertensive patients with covid-19 date: 2020-08-14 words: 3590 flesch: 37 summary: In this prospective study, we analyzed covid-19 hypertensive patients consecutively admitted to the Department of Infectious Disease at University of Campania Luigi Vanvitelli, Naples, Italy between February 10, 2020 and April 20, 2020. Such a negative correlation between hypertension and clinical prognosis in covid-19 patients has been deeply investigated in recent trials [1, 2] . keywords: blood; blood group; covid-19; data; death; group; infection; injury; patients; study cache: cord-323906-ro078y52.txt plain text: cord-323906-ro078y52.txt item: #2146 of 2876 id: cord-323910-lms3xw4k author: Putman, Michael title: Antirheumatic Disease Therapies for the Treatment of COVID‐19: A Systematic Review and Meta‐analysis date: 2020-08-02 words: 4594 flesch: 38 summary: Included studies described one or more relevant clinical outcomes in five or more people who were infected with SARS‐CoV‐2 and were treated with antirheumatic disease therapy between 01/01/2019 and 05/29/2020. Infectious Diseases (except HIV/AIDS) Tocilizumab therapy reduced intensive care unit admissions and/or mortality in COVID-19 patients Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: results from a single Italian Centre study on tocilizumab versus standard of care keywords: bias; cohort; covid-19; disease; hydroxychloroquine; mortality; patients; risk; studies; study cache: cord-323910-lms3xw4k.txt plain text: cord-323910-lms3xw4k.txt item: #2147 of 2876 id: cord-323913-v32c2vda author: Istúriz, Raul E. title: Global Distribution of Infectious Diseases Requiring Intensive Care date: 2006-07-31 words: 7134 flesch: 41 summary: Prostration is common in severe disease and may progress to stupor and coma. The excess morbidity and mortality associated with influenza epidemics and the increased hospitalization costs are secondary to severe cases of the disease [28] . keywords: acute; areas; care; cases; disease; failure; fever; hepatitis; high; infection; liver; mortality; patients; rabies; sepsis; syndrome; treatment; virus cache: cord-323913-v32c2vda.txt plain text: cord-323913-v32c2vda.txt item: #2148 of 2876 id: cord-323940-ubazgvov author: Cafiero, Concetta title: Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease date: 2020-10-13 words: 7372 flesch: 26 summary: • PharmGKB website provides a diverse array of PGx information, from annotations of the primary literature to guidelines for adjusting drug treatment based on genetic information. To our knowledge, although a considerable number of ADR episodes in Covid-19 patients have to date been described in the literature, there has been no pharmacogenetic study attempting to correlate the clinical outcomes of drug treatment with gene variants. keywords: coronavirus; cov2; covid-19; disease; drug; effects; efficacy; infection; patients; pharmacogenetic; response; sars; studies; study; therapy; toxicity; treatment; use; variants cache: cord-323940-ubazgvov.txt plain text: cord-323940-ubazgvov.txt item: #2149 of 2876 id: cord-323965-6mzzibj8 author: Kapoor, Krishan Mohan title: COVID‐19 Pandemic: Consensus Guidelines for Preferred Practices in an Aesthetic Clinic date: 2020-05-16 words: 3358 flesch: 44 summary: The general guidelines for aesthetic procedures also included minimum conversations with the patient during the procedure, not allowing the patient attendant to be in the procedure room, and also avoid the helping staff/nurse to be in the procedure room while the procedure is being performed, if possible. In aesthetic clinics, most procedures are provided on one to one basis by the physician or therapist. keywords: clinic; consensus; covid-19; guidelines; infection; patient; procedure; risk; staff cache: cord-323965-6mzzibj8.txt plain text: cord-323965-6mzzibj8.txt item: #2150 of 2876 id: cord-323980-rcyjthze author: Willems, Laurent M. title: SARS-CoV-2-related rapid reorganization of an epilepsy outpatient clinic from personal appointments to telemedicine services: A German single-center experience date: 2020-10-06 words: 4382 flesch: 33 summary: Patients with epilepsy may be a highly vulnerable group for such supply problems, given the driving restrictions applied to patients with ongoing seizures [43] . When the SARS-CoV-2 pandemic reached Europe in 2020, a German governmental order forced clinics to immediately suspend elective care, causing a problem for patients with chronic illnesses such as epilepsy. keywords: care; cov-2; covid-19; epilepsy; face; patients; sars; telemedicine cache: cord-323980-rcyjthze.txt plain text: cord-323980-rcyjthze.txt item: #2151 of 2876 id: cord-324007-hapzf0fl author: McGeer, Allison J. title: Diagnostic Testing or Empirical Therapy for Patients Hospitalized with Suspected Influenza: What to Do? date: 2009-01-01 words: 2895 flesch: 31 summary: [16] , who demonstrated that hospitalized patients receiving treatment with rimantadine and zanamivir shed influenza virus for several days after hospital admission. Such a policy will have a low risk of adverse events and a low risk of increasing selective pressure for the development of resistant strains of influenza virus. keywords: hospital; influenza; oseltamivir; patients; therapy; treatment cache: cord-324007-hapzf0fl.txt plain text: cord-324007-hapzf0fl.txt item: #2152 of 2876 id: cord-324041-lqokztor author: Saussez, Sven title: Anosmia: an evolution of our understanding of its importance in COVID-19 and what questions remain to be answered date: 2020-09-09 words: 3083 flesch: 36 summary: Loss of sense of smell as marker of COVID-19 infection Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Loss of smell and taste in 2013 European patients with mild to moderate COVID-19 Psychophysical olfactory tests and detection of COVID-19 in patients with sudden onset olfactory dysfunction: a prospective study Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry Smell dysfunction: a biomarker for COVID-19 Anosmia in COVID-19 patients Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study Early recovery following new onset anosmia during the COVID-19 pandemic: an observational cohort study Smell and taste recovery in COVID-19 patients: A 60 day objective and prospective study Elevated ACE2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-COV-2 entry and replication Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2) In that way, we observed that severe patients have less ear, nose and throat complaints than mild patients [2, 3] , where the ENT symptoms are prevalent. keywords: anosmia; covid-19; infection; loss; olfactory; patients cache: cord-324041-lqokztor.txt plain text: cord-324041-lqokztor.txt item: #2153 of 2876 id: cord-324060-vvexfg1c author: Bogdanos, Dimitrios P. title: When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients? date: 2020-03-31 words: 2737 flesch: 46 summary: key: cord-324060-vvexfg1c authors: Bogdanos, Dimitrios P.; Daniil, Zoi; Zakynthinos, Epaminondas; Gourgoulianis, Konstantinos; Sakkas, Lazaros I. title: When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients? date: 2020-03-31 journal: The safety profile of the drug specifically for COVID-19 treated patients is also a topic of intense research. keywords: chloroquine; coronavirus; covid-19; drug; hydroxychloroquine; patients; pneumonia; treatment cache: cord-324060-vvexfg1c.txt plain text: cord-324060-vvexfg1c.txt item: #2154 of 2876 id: cord-324125-wau2xq0x author: Qiu, Chao title: Epidemiologic report and serologic findings for household contacts of three cases of influenza A (H7N9) virus infection date: 2013-12-16 words: 1821 flesch: 48 summary: Consistent with the observations in studies of H7N9 virus transmission in animal models, our results indicate that compared with globally disseminated seasonal and pandemic influenza viruses, the H7N9 virus is not readily transmitted in certain household settings Antibodies against H7N9 virus in serum samples were tested using hemagglutination inhibition and pseudovirus based neutralization assays. keywords: case; contacts; h7n9; influenza; virus cache: cord-324125-wau2xq0x.txt plain text: cord-324125-wau2xq0x.txt item: #2155 of 2876 id: cord-324148-bllyruh8 author: Loubet, Paul title: Characteristics of human metapneumovirus infection in adults hospitalized for community-acquired influenza-like illness in France, 2012-2018: a retrospective observational study date: 2020-04-10 words: 1553 flesch: 40 summary: This was a retrospective, observational, multicenter cohort study using prospectively collected data from adult patients hospitalized during influenza virus circulation, for at least 24h, for community-acquired ILI (with symptom onset <7 days). In our post-hoc analysis of 3148 hospitalized adult patients with community-acquired ILI, 211 hMPV was found in 3% of the samples. keywords: hmpv; infection; influenza; patients cache: cord-324148-bllyruh8.txt plain text: cord-324148-bllyruh8.txt item: #2156 of 2876 id: cord-324159-jv3lknl8 author: Ashraf, Muddasir title: Acute Stroke in a Young Patient With Coronavirus Disease 2019 in the Presence of Patent Foramen Ovale date: 2020-09-03 words: 1737 flesch: 45 summary: We did start the patient on prophylactic enoxaparin sodium, which is the standard of care in stroke patients admitted to the hospital for deep venous thrombosis prophylaxis. Large-vessel stroke as a presenting feature of COVID-19 in the young Incidence of thrombotic complications in critically ill ICU patients with COVID-19 High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in The Factor VIII acute phase response requires the participation of NFkappaB and C/EBP Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases COVID-19-associated hyperviscosity: a link between inflammation and thrombophilia? Hypercoagulability of COVID-19 patients in the intensive care unit: a report of thromboelastography findings and other parameters of Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Exploring possible mechanisms for COVID-19 induced thrombocytopenia: unanswered questions The versatile heparin in COVID-19 Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Lupus anticoagulant and abnormal coagulation tests in patients with Covid-19 keywords: acute; covid-19; patients; stroke cache: cord-324159-jv3lknl8.txt plain text: cord-324159-jv3lknl8.txt item: #2157 of 2876 id: cord-324175-5c4ijkpm author: Kassas, Mohamed El title: COVID-19 in Egypt: Through Crisis to Adaptation; a gastroenterologist’s Perspective date: 2020-07-19 words: 2417 flesch: 36 summary: High levels of care for liver disease patients are not provided universally everywhere in Egypt, and sometimes patients have to travel for hundred kilometers to reach tertiary care centers where they are followed up. First, cancer patients are exposed to infection while on their way to cancer centers to receive their medications. keywords: covid-19; egypt; hepatitis; infection; liver; pandemic; patients cache: cord-324175-5c4ijkpm.txt plain text: cord-324175-5c4ijkpm.txt item: #2158 of 2876 id: cord-324232-nupi7f72 author: Villar, Jesús title: Rationale for Prolonged Corticosteroid Treatment in the Acute Respiratory Distress Syndrome Caused by Coronavirus Disease 2019 date: 2020-04-29 words: 2382 flesch: 31 summary: Recommendations for COVID-19 clinical management Treatment of severe acute respiratory syndrome with glucosteroids: The Guangzhou experience An exploratory reanalysis of the randomized trial on efficacy of corticosteroids as rescue therapy for the late phase of acute respiratory distress syndrome Second, they ignored the positive findings of two large studies (5,327 patients with severe acute respiratory syndrome [SARS] keywords: ards; corticosteroids; covid-19; patients; syndrome; treatment cache: cord-324232-nupi7f72.txt plain text: cord-324232-nupi7f72.txt item: #2159 of 2876 id: cord-324245-cfiekxr4 author: Giorgi-Pierfranceschi, Matteo title: Prevalence of asymptomatic deep vein thrombosis in patients hospitalized with SARS-CoV-2 pneumonia: a cross-sectional study date: 2020-08-25 words: 3775 flesch: 33 summary: Prophylaxis in Medical Patients with Enoxaparin Study Group Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients Investigators ARTEMIS (2006) Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomized placebo-controlled trial Venous thromboembolism prophylaxis with unfractionated heparin in the hospitalized medical patient: the case for thrice daily over twice daily dosing Duration of venous thromboembolism risk across a continuum in medically ill hospitalized patients Chemical prophylaxis to prevent venous thromboembolism in morbid obesity: literature review and dosing recommendations Venous thromboembolism prophylaxis in critically ill patients Venous thromboembolism in the ICU: main characteristics, diagnosis and thromboprophylaxis VTE incidence and risk factors in patients with severe sepsis and septic shock A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score Scoring systems for estimating risk of venous thromboembolism in hospitalized medical patients Publication WHO REFERENCE NUMBER: WHO/COVID-19/laboratory/2020 Ultrasound for lower extremity deep venous thrombosis: multidisciplinary recommendations from the society of radiologists in ultrasound consensus conference Detection of deep-vein thrombosis by real-time B-mode ultrasonography Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Autopsy findings and venous thromboembolism in patients with COVID-19 Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study Prevent Medical Thromboprophylaxis Study Group, Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients Cao Bin (2020) VTE represents a frequent and potentially fatal complication in hospitalized patients. keywords: covid-19; dvt; patients; pneumonia; prophylaxis; risk; standard; study; thromboembolism cache: cord-324245-cfiekxr4.txt plain text: cord-324245-cfiekxr4.txt item: #2160 of 2876 id: cord-324314-os1btxx1 author: Park, Jaehyeon title: Departments of Radiation Oncology Must Prepare for COVID-19 Outbreak date: 2020-04-25 words: 763 flesch: 53 summary: The movement, space, and treatment time of the infected person should be separated from general treatment patients. The therapist contact between treatment rooms or visits to treatment room by doctors should be minimized. keywords: patients; room; treatment cache: cord-324314-os1btxx1.txt plain text: cord-324314-os1btxx1.txt item: #2161 of 2876 id: cord-324529-xbrdtxnz author: Wang, Ming title: Clinical characteristics and risk factors of liver injury in COVID-19: a retrospective cohort study from Wuhan, China date: 2020-10-07 words: 4055 flesch: 45 summary: There were significant differences in laboratory findings between COVID-19 patients with or without liver injury, including higher white blood cell, neutrophil and lower lymphocyte count in liver injury patients than those without. Liver injury is a common complication in COVID-19 patients. keywords: covid-19; data; disease; injury; liver; liver injury; patients; risk; study cache: cord-324529-xbrdtxnz.txt plain text: cord-324529-xbrdtxnz.txt item: #2162 of 2876 id: cord-324601-s3rgxtg6 author: Mhimbira, F. title: Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in Tanzania: a cohort study date: 2019-01-31 words: 3262 flesch: 38 summary: TB patients and controls did not differ in the prevalence of respiratory viruses (Odds Ratio [OR] 1.00, 95%CI 0.71–1.44), but respiratory bacteria were less frequently detected in TB patients (OR 0.70, 95%CI 0.53–0.94). TB patients with respiratory viruses tended to have more frequent lung cavitations (aOR 1.6, 95%CI 0.93–2.7; p 0.089). keywords: controls; household; pathogens; patients; study; tuberculosis; viruses cache: cord-324601-s3rgxtg6.txt plain text: cord-324601-s3rgxtg6.txt item: #2163 of 2876 id: cord-324619-y7gilopu author: Alam, S.B. title: Severe acute respiratory syndrome coronavirus‐2 may be an underappreciated pathogen of the central nervous system date: 2020-07-15 words: 5255 flesch: 28 summary: A retrospective study from China found that COVID-19 patients over 60 years old and with neurologic comorbidities were at a higher risk of developing neurologic impairments such as impaired consciousness and cerebrovascular accidents (18). It is possible that COVID-19 patients that have experienced SARS-CoV-2 infection of the CNS via the neuromuscular junction could experience similar complications and long-term follow-up of these patients should be prioritized. keywords: article; brain; cells; cns; coronavirus; cov-2; covid-19; disease; human; infection; patients; sars cache: cord-324619-y7gilopu.txt plain text: cord-324619-y7gilopu.txt item: #2164 of 2876 id: cord-324635-27q3nxte author: Bouza, Emilio title: The situation of infection in the elderly in Spain: a multidisciplinary opinion document date: 2020-09-08 words: 15951 flesch: 42 summary: In a study conducted in China, in 6 sentinel hospitals, it was observed that 31.64% of elderly patients with respiratory infection had a viral aetiology (41.8% among extra-hospital infections and 25.7% among fecting the elderly vary depending on the clinical environment (home, nursing home, hospital) and the functional status of the patient. It is interesting to note the safety of using the same therapeutic options in elderly patients, including faecal microbiota transplantation [29, 30] . keywords: age; care; cases; community; control; data; diseases; emergency; health; healthcare; homes; hospital; infections; information; life; nursing; patients; people; pneumonia; population; prevalence; prevention; problems; spain; spanish; study; term; tract; treatment; use; years cache: cord-324635-27q3nxte.txt plain text: cord-324635-27q3nxte.txt item: #2165 of 2876 id: cord-324666-fvk72o0p author: Alharbi, Musa title: Regression of ETV6-NTRK3 Infantile Glioblastoma After First-Line Treatment With Larotrectinib date: 2020-06-30 words: 2060 flesch: 33 summary: This patient case highlights the importance of genomic profiling for pediatric brain tumors to identify targetable alterations. 9 High-grade gliomas (HGGs) account for approximately 10% of pediatric brain tumors and are the second most common malignant CNS tumor after medulloblastoma. keywords: fusion; glioblastoma; larotrectinib; patient; pediatric; trk; tumors cache: cord-324666-fvk72o0p.txt plain text: cord-324666-fvk72o0p.txt item: #2166 of 2876 id: cord-324669-qca0uwxo author: Radermecker, Coraline title: Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19 date: 2020-09-14 words: 4897 flesch: 34 summary: Meng et al., 2017; Barnes et al., 2020) , and fibrosis (Chrysanthopoulou et al., 2014; Savchenko et al., 2014) , three features encountered in severe forms of COVID-19 patients (Ackermann et al., 2020; Wang et al., 2020; Guan et al., 2020; Zhou et al., 2020; Connors and Levy, 2020) . Moreover, NET components have been detected in the sera of COVID-19 patients and correlated with disease severity (Zuo et al., 2020; Middleton et al., 2020) . keywords: cit; covid-19; et al; formation; lung; mpo; nets; neutrophil; patients; sections; table; traps cache: cord-324669-qca0uwxo.txt plain text: cord-324669-qca0uwxo.txt item: #2167 of 2876 id: cord-324679-rds8o5z4 author: Grant, Vincent J. title: The Past, Present, and Future of Simulation-based Education for Pediatric Emergency Medicine date: 2016-05-26 words: 5712 flesch: 30 summary: [13] [14] Because these patients are some of the more complex within the PEM environment, from both a clinical and team dynamics standpoint, simulation training is a natural fit for pediatric trauma and has been shown to improve the quality of care provided in different studies. As discussed above, these skills remain the predominant focus of simulation training in fellowship programs. keywords: care; education; emergency; environment; family; patient; pediatric; pem; simulation; skills; team; training cache: cord-324679-rds8o5z4.txt plain text: cord-324679-rds8o5z4.txt item: #2168 of 2876 id: cord-324798-qh0cxp10 author: Tanaka, Miho title: Forgoing life-sustaining treatment – a comparative analysis of regulations in Japan, Korea, Taiwan, and England date: 2020-10-16 words: 12041 flesch: 49 summary: Meanwhile, the Taiwan Act interprets the terminal stage more conservatively and considers terminal patients to be those who have been diagnosed as having an incurable disease or injury, and who cannot avoid death shortly based on the best available medical evidence. Moreover, patients who are diagnosed with such incurable diseases might feel threatened because the regulatory framework such as law or guidelines would classify them as terminal patients who can have their treatments withdrawn. keywords: act; care; countries; decision; end; family; forgoing; guideline; life; life care; lst; medical; patient; stage; treatment cache: cord-324798-qh0cxp10.txt plain text: cord-324798-qh0cxp10.txt item: #2169 of 2876 id: cord-324809-16zvqizl author: Mehta, Neil title: Surveillance and Monitoring of Hepatocellular Carcinoma During the COVID-19 Pandemic date: 2020-07-08 words: 4805 flesch: 21 summary: Waitlisted patients who will benefit from urgent LT should be prioritized for surveillance whereas it would be reasonable to extend surveillance interval by a short period in HCC patients with lower risk tumor features and those more than 2 years since their last treatment. HCC patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 keywords: carcinoma; cirrhosis; covid-19; hcc; hepatocellular; imaging; liver; patients; risk; surveillance; treatment cache: cord-324809-16zvqizl.txt plain text: cord-324809-16zvqizl.txt item: #2170 of 2876 id: cord-324810-92fosk3c author: Sharma, Sat title: Role of Antimicrobial Agents in the Management of Exacerbations of COPD date: 2012-08-23 words: 9362 flesch: 33 summary: Antimicrob Agents sis of risk factors for infection due to penicillin resistant and multidrug resistant Chemother the treatment of acute exacerbation of chronic bronchitis: results of a randomized, double-blind study Randomized, double-blind study comparing 5-and 7-treatment of adults with lower respiratory tract infections and effects on long day regimens of oral levofloxacin in patients with acute exacerbations of term outcome Comparison of 5-day, short cause azithromycin levofloxacin in the outpatient treatment of acute bacterial exacerbations of 97-107 chronic bronchitis Efficacy and tolerability of gatifloxacin A comparison of 5-day courses of in community treatment of acute exacerbations of chronic bronchitis. J Int ment of patients with acute bacterial exacerbation of chronic bronchitis Studio Multicentrico con Moxifloxacina nel release clarithromycin tablets and amoxicillin/clavulanate tablets in the treat-Trattamento delle Riacutizzazioni de Bronchite Cronica Short-term and long-term outcomes of comparative study of clarithromycin modified release and amoxicillin/clavumoxifloxacin compared to standard antibiotic treatment in acute exacerbations lanic acid in the treatment of acute exacerbation of chronic bronchitis A review of the comparative in vitro activities of 12 antimicrobial agents, with a focus on five new respiratory quinolones. keywords: acute; aecopd; antimicrobial; bacterial; bronchitis; chronic; disease; exacerbations; failure; influenzae; patients; resistance; sputum; study; therapy; treatment cache: cord-324810-92fosk3c.txt plain text: cord-324810-92fosk3c.txt item: #2171 of 2876 id: cord-324843-r43u7sld author: Kockuzu, Esra title: Comprehensive Analysis of Severe Viral Infections of Respiratory Tract admitted to PICUs during the Winter Season in Turkey date: 2019-06-17 words: 3751 flesch: 45 summary: The critically ill child with novel H1N1 influenza A: a case series Continued high incidence of children with severe influenza A(H1N1) pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational populationbased study Human bocavirus and KI/WU polyomaviruses in pediatric intensive care patients Human metapneumovirus infection among children hospitalized with acute respiratory illness Human coronavirus in the 2014 winter season as a cause of lower respiratory tract infection Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Premorbid factors and outcomes associated with respiratory virus infections in a pediatric intensive care unit Hospital-acquired viral infection increases mortality in children with severe viral respiratory infection An investigation into the prevalence and outcome of patients admitted to a pediatric intensive care unit with viral respiratory tract infections in Cape Town, South Africa The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics WHO estimates of the causes of death in children Extrapulmonary manifestations of severe respiratory syncytial virus infection-a systematic review Atypical extrapulmonary presentations of severe respiratory syncytial virus infection requiring intensive care Human bocavirus infection as a cause of severe acute respiratory tract infection in children Critically ill patients with 2009 influenza A(H1N1) infection in Canada Critically ill children with pandemic influenza (H1N1) in pediatric intensive care units in Turkey keywords: age; children; infections; influenza; mortality; patients; viruses cache: cord-324843-r43u7sld.txt plain text: cord-324843-r43u7sld.txt item: #2172 of 2876 id: cord-324859-0yuhb5dl author: Mulchandani, Rubina title: Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis date: 2020-11-02 words: 6722 flesch: 39 summary: Well‐designed and adequately powered prospective studies are needed to amplify the current evidence and provide definitive answers to dilemmas regarding timing and type of anti‐COVID‐19 therapy particularly in severe patients. 58 53% M Not given 13 55 The number of T cells and CD8 + T cells was significantly lower in severe patients than that in the mild cases. keywords: analysis; coronavirus; covid-19; cytokine; disease; il-6; inflammatory; levels; meta; patients; studies; study cache: cord-324859-0yuhb5dl.txt plain text: cord-324859-0yuhb5dl.txt item: #2173 of 2876 id: cord-324880-s1oqkqef author: Xu, Lili title: A fatal case associated with respiratory syncytial virus infection in a young child date: 2018-05-11 words: 3289 flesch: 41 summary: RSV infections: state of the art The burden of respiratory syncytial virus infection in young children Updated guidance for Palivizumab prophylaxis among infants and young children at increased risk of hospitalization for respiratory syncytial virus infection Predicting deterioration in previously healthy infants hospitalized with respiratory syncytial virus infection Examination of neurological prognostic markers in patients with respiratory syncytial virus-associated encephalopathy Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein Extrapulmonary manifestations of severe respiratory syncytial virus infection-a systematic review Risk factors for respiratory syncytial virus associated apnoea Neurological complications of respiratory syncytial virus infection: case series and review of literature Reflex apnoea response and inflammatory mediators in infants with respiratory tract infection Detection of subgroup B respiratory syncytial virus in the cerebrospinal fluid of a patient with respiratory syncytial virus pneumonia Respiratory syncytial virus-related encephalitis: magnetic resonance imaging findings with diffusion-weighted study The Spectrum and burden of influenza-associated neurological disease in children: combined encephalitis and influenza sentinel site surveillance from Australia PCR on cerebrospinal fluid to show influenzaassociated acute encephalopathy or encephalitis Influenza-associated acute encephalopathy in Japanese children in 1994-2002 Neurologic complications associated with novel influenza a (H1N1) virus infection in children Encephalitis and encephalopathy associated with an influenza epidemic in Japan Detection of influenza virus RNA by reverse transcription-PCR and proinflammatory cytokines in influenza-virus-associated encephalopathy This study was approved by the Ethical Review Committee of Beijing Children's Hospital. key: cord-324880-s1oqkqef authors: Xu, Lili; Gao, Hengmiao; Zeng, Jiansheng; Liu, Jun; Lu, Cong; Guan, Xiaolei; Qian, Suyun; Xie, Zhengde title: A fatal case associated with respiratory syncytial virus infection in a young child date: 2018-05-11 journal: BMC Infect Dis DOI: 10.1186/s12879-018-3123-8 sha: doc_id: 324880 cord_uid: s1oqkqef BACKGROUND: Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. keywords: disease; encephalitis; fever; infection; influenza; patient; rsv; symptoms; virus cache: cord-324880-s1oqkqef.txt plain text: cord-324880-s1oqkqef.txt item: #2174 of 2876 id: cord-324918-36om8n2d author: Guha, Chandana title: Suspension and resumption of kidney transplant programs during the COVID‐19 pandemic: perspectives from patients, caregivers and potential living donors‐a qualitative study date: 2020-07-08 words: 3497 flesch: 45 summary: This study aims to describe the perspectives of kidney transplant candidates, caregivers and potential donors on the suspension and resumption of kidney transplant programs. key: cord-324918-36om8n2d authors: Guha, Chandana; Tong, Allison; Baumgart, Amanda; Scholes‐Robertson, Nicole; Isbel, Nicole; Kanellis, John; Campbell, Scott; Coates, Toby; Chadban, Steven title: Suspension and resumption of kidney transplant programs during the COVID‐19 pandemic: perspectives from patients, caregivers and potential living donors‐a qualitative study date: 2020-07-08 journal: Transpl Int DOI: 10.1111/tri.13697 sha: doc_id: 324918 cord_uid: 36om8n2d BACKGROUND: Many countries have suspended kidney transplantation programs during the COVID‐19 pandemic because of concerns for patient safety and the shortage of healthcare resources. keywords: covid-19; kidney; patients; programs; suspension; transplant; transplantation cache: cord-324918-36om8n2d.txt plain text: cord-324918-36om8n2d.txt item: #2175 of 2876 id: cord-324944-ixh3ykrc author: Mitsakakis, Konstantinos title: Diagnostic tools for tackling febrile illness and enhancing patient management date: 2018-12-05 words: 20813 flesch: 41 summary: This review gives an overview of diagnostic technologies featuring a platform based approach: (i) assay (nucleic acid amplification technologies are examined); (ii) cartridge (microfluidic technologies are presented); (iii) instrument (various detection technologies are discussed); and at the end proposes a way that such technologies can be interfaced with electronic clinical decision-making algorithms towards a broad and complete diagnostic ecosystem. Nucleic acid amplification technologies (NAATs) are based on sequence-specific recognition and amplification of unique target regions in the genome of pathogens to be detected. keywords: acid; amplification; assay; blood; care; cartridge; detection; diagnosis; diseases; dna; e.g.; febrile; fever; fig; health; infections; malaria; management; nucleic; patients; pcr; platform; point; process; reaction; reagents; sample; specific; system; target; technologies; technology; test; time; tools; use; virus cache: cord-324944-ixh3ykrc.txt plain text: cord-324944-ixh3ykrc.txt item: #2176 of 2876 id: cord-325201-yoy7kdli author: Timsit, Jean-François title: Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics date: 2015-03-26 words: 9133 flesch: 38 summary: Under this context, recent studies shed more light on the aminoglycoside PK/PD properties in ICU patients. Energy deficit in ICU patients is mainly caused by reduced intake due to under-prescribed calories and frequent feeding interruptions. keywords: candida; care; colonization; escalation; icu; infections; intensive; mortality; patients; pneumonia; sepsis; shock; study; therapy; treatment; use cache: cord-325201-yoy7kdli.txt plain text: cord-325201-yoy7kdli.txt item: #2177 of 2876 id: cord-325234-skshcrh1 author: Jin, Tingxu title: SARS-CoV-2 presented in the air of an intensive care unit (ICU) date: 2020-08-15 words: 4279 flesch: 41 summary: Therefore, with an objective to test the hypothesis of airborne transmission of SARS-CoV-2, it is necessary to 1) determine whether SARS-CoV-2 particles are present in the indoor air and 2) determine whether recovered patients are still shedding virus, thus providing much-needed environmental evidence for the management of COVID-19 patients during the recovery period. Therefore, our study aims to 1) determine whether SARS-CoV-2 particles are present in the indoor air, with an objective to test the hypothesis of airborne transmission of SARS-CoV-2, and 2) determine whether recovered patients are still shedding SARS-CoV-2 particles, thus providing much-needed environmental evidence for the management of COVID-19 patients during the recovery period. keywords: air; cov-2; covid-19; patients; samples; sars; study; transmission cache: cord-325234-skshcrh1.txt plain text: cord-325234-skshcrh1.txt item: #2178 of 2876 id: cord-325307-agaau27o author: Giavedoni, Priscila title: Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity date: 2020-10-12 words: 4311 flesch: 34 summary: Second, we provide an accurate description of the prevalence of skin lesions in COVID-19 patients. Moreover, differentiating chilblain-like lesions from idiopathic and lupus-associated chilblain lesions, and other types of lesions such as generalized maculopapular or urticarial eruptions from drug reactions, is essential, given the frequency and characteristics of the former and the difficulties posed by the latter due to the large number of drugs usually concomitantly received by COVID-19 patients. keywords: cases; chilblain; covid-19; disease; hospital; lesions; patients; skin; study cache: cord-325307-agaau27o.txt plain text: cord-325307-agaau27o.txt item: #2179 of 2876 id: cord-325316-uffxyas1 author: Gagliano, Annalisa title: COVID-19 Epidemic in the Middle Province of Northern Italy: Impact, Logistics, and Strategy in the First Line Hospital date: 2020-03-24 words: 3121 flesch: 43 summary: The crisis unit was formed involving hospital staff (general health, nursing), department directors, logistics heads, representatives of critical units in the management of COVID-19 patients, and press coordinator. In the same way, decentralized management of the first phase in the frontline hospital has allowed other structures, albeit in different ways, to prepare suitable space and line of management for COVID-19 patients. keywords: beds; coronavirus; covid-19; health; hospital; management; patients cache: cord-325316-uffxyas1.txt plain text: cord-325316-uffxyas1.txt item: #2180 of 2876 id: cord-325421-1ysn0kyr author: Christensen, Johanna title: Covid-19 Viremia, Serologies and Clinical Course in a Case Series of Transplant Recipients date: 2020-09-03 words: 2551 flesch: 48 summary: The many faces of the anti-COVID immune response Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study Early detection of SARS-CoV-2 antibodies in COVID-19 patients as a serologic marker of infection Validation of a Clinical-Grade Assay to Measure Donor-Derived Cell-Free DNA in Solid Organ Transplant Recipients Clinical features of patients infected with 2019 novel coronavirus in Wuhan A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster COVID-19 Testing: The Threat of False-Negative Results Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: Patients Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19 Treatment with convalescent plasma for COVID-19 patients in Wuhan Convalescent plasma: A possible treatment of COVID-19 in India Endothelial cell infection and endotheliitis in COVID-19 Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury Graft-derived cell-free DNA as an early organ integrity biomarker after transplantation of a marginal HELLP syndrome donor liver Johanna Christensen: keywords: covid-19; patients; sars; time; transplant cache: cord-325421-1ysn0kyr.txt plain text: cord-325421-1ysn0kyr.txt item: #2181 of 2876 id: cord-325511-ot66dj3i author: Kim, Philip title: Managing Intrathecal Drug Delivery Devices in a Global Pandemic date: 2020-05-13 words: 724 flesch: 48 summary: 2. Have patient wear masks or cover to reduce spread. Many patients have combination of therapies that may cause sudden severe and life-threatening withdrawal reactions such as intrathecal clonidine as with hypertensive crisis and cardiomyopathy (1, 2) . keywords: covid-19; intrathecal; life cache: cord-325511-ot66dj3i.txt plain text: cord-325511-ot66dj3i.txt item: #2182 of 2876 id: cord-325619-qmszgw66 author: Ferrari, Andrea title: Children with cancer in the time of COVID‐19: An 8‐week report from the six pediatric onco‐hematology centers in Lombardia, Italy date: 2020-05-26 words: 978 flesch: 34 summary: :e28327 Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Prevalence and characteristics of acute respiratory virus infections in pediatric cancer patients Flash survey on SARS-CoV-2 infections in pediatric patients on anti-cancer treatment Risk of COVID-19 for patients with cancer How young patients with cancer perceive the COVID-19 (coronavirus) epidemic in Milan, Italy: is there room for other fears? Although preliminary, our findings suggest that anticancer treatments for pediatric patients can continue with no major adjustments. keywords: cancer; cases; covid-19; patients cache: cord-325619-qmszgw66.txt plain text: cord-325619-qmszgw66.txt item: #2183 of 2876 id: cord-325628-pa3dkz2f author: Wang, Jinsong title: Strategy for treating vascular emergencies during the COVID-19 pandemic in China date: 2020-06-01 words: 1200 flesch: 40 summary: Clinicians treating COVID-19 patients face considerable danger of occupational exposure due to the highly infectious nature of the virus and precautions must be taken to prevent medical staff infections. Patients who have unstable vital signs and cannot be screened should be treated as if they 20 were confirmed COVID-19 patients. keywords: covid-19; patients; treatment; vascular cache: cord-325628-pa3dkz2f.txt plain text: cord-325628-pa3dkz2f.txt item: #2184 of 2876 id: cord-325631-c7jwizpj author: Masetti, Chiara title: High mortality in COVID‐19 patients with mild respiratory disease date: 2020-06-29 words: 2541 flesch: 38 summary: Clinical evaluation of COVID-19 patients depends on the severity of the disease, and since no proven therapy has been so far approved, hospitalization is warranted for observation and supportive care. In our analysis, our aim was to identify risk factors for a predictor model in COVID-19 patients accessing to ER with mild symptoms. keywords: analysis; clinical; coronavirus; covid-19; disease; mortality; patients cache: cord-325631-c7jwizpj.txt plain text: cord-325631-c7jwizpj.txt item: #2185 of 2876 id: cord-325649-zzhsrytw author: Rispoli, Rossella title: Spine surgery in Italy in the COVID-19 era: Proposal for assessing and responding to the regional state of emergency date: 2020-08-07 words: 2783 flesch: 44 summary: The alert level data points relative to the FVG Region of northeast Italy are shown in white points in The proposal for prioritizing surgical activities in relation to health care system alert levels is given in All these patients were admitted urgently due to the onset with neurological deficits and, in one case, for early signs of infection. By the time of the World Health Organization (WHO) classification of the novel coronavirus as a global pandemic (1) , many hospitals in northern Italy were already overcrowded by COVID-19 patients, especially intensive care units, where about 50% of all available ICU beds were occupied by COVID-19 patients ( 2 ) . keywords: care; covid-19; health; patients; spine; surgery; system cache: cord-325649-zzhsrytw.txt plain text: cord-325649-zzhsrytw.txt item: #2186 of 2876 id: cord-325655-1fktmpbj author: Sun, Dan-Qin title: Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study date: 2020-05-26 words: 914 flesch: 40 summary: However, the current definition of AKI does not provide a measurement of loss of kidney function because serum creatinine level is not a sensitive marker of early tubular injury (elevation of serum creatinine requires damage/dysfunction of >50% of the nephron mass), whereas biomarkers of tubular injury provide information on early kidney injury and response to noxious stimuli Previous studies have reported that ∼10% of infected patients may develop acute kidney injury (AKI), which is a strong prognostic factor increasing risk of death keywords: kidney; patients cache: cord-325655-1fktmpbj.txt plain text: cord-325655-1fktmpbj.txt item: #2187 of 2876 id: cord-325700-f102uk2m author: Fraser, Douglas D. title: Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers date: 2020-10-21 words: 5712 flesch: 33 summary: Although plasma kynurenine effectively discriminated COVID19+ patients from healthy control subjects, determination of COVID19 status in ICU patients required further specificity that was optimally provided by an arginine/kynurenine ratio. None. MEASUREMENTS AND MAIN RESULTS: Age- and sex-matched healthy controls and ICU patients that were either coronavirus disease 2019 positive or coronavirus disease 2019 negative were enrolled. keywords: arginine; control; coronavirus; coronavirus disease; covid19; creatinine; disease; icu; kynurenine; metabolites; patients; ratio; subjects cache: cord-325700-f102uk2m.txt plain text: cord-325700-f102uk2m.txt item: #2188 of 2876 id: cord-325766-hbppklm5 author: Brienza, Nicola title: Acute Kidney Injury in Coronavirus Disease 2019 Infected Patients: A Meta-Analytic Study date: 2020-07-02 words: 2925 flesch: 47 summary: All trials reporting the incidence of AKI in COVID-19 patients were searched using MEDLINE, the Cochrane Library, and EMBASE databases (last update April 26, 2020). All trials reporting the incidence of AKI in COVID-19 patients were analyzed. keywords: aki; covid-19; kidney; patients; studies; trials cache: cord-325766-hbppklm5.txt plain text: cord-325766-hbppklm5.txt item: #2189 of 2876 id: cord-325783-pqonn0as author: Nicholls, John M title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 words: 4029 flesch: 44 summary: The histological changes of uncomplicated viral pneumonias are rarely described, and reports tend to be derived from post-mortem examination of patients who succumb to the pneumonia; thus, they may not be representative of the majority of pneumonia patients, who survive. key: cord-325783-pqonn0as authors: Nicholls, John M; Poon, Leo LM; Lee, Kam C; Ng, Wai F; Lai, Sik T; Leung, Chung Y; Chu, Chung M; Hui, Pak K; Mak, Kong L; Lim, Wilna; Yan, Kin W; Chan, Kwok H; Tsang, Ngai C; Guan, Yi; Yuen, Kwok Y; Malik Peiris, JS title: Lung pathology of fatal severe acute respiratory syndrome date: 2003-05-24 journal: Lancet DOI: 10.1016/s0140-6736(03)13413-7 sha: doc_id: 325783 cord_uid: pqonn0as BACKGROUND: Severe acute respiratory syndrome (SARS) is a novel infectious disease with global impact. keywords: coronavirus; disease; influenza; lung; march; patients; pneumonia; sars; syndrome cache: cord-325783-pqonn0as.txt plain text: cord-325783-pqonn0as.txt item: #2190 of 2876 id: cord-325793-5vrr7msw author: Lahiry, Anup K. title: Dermatosurgery Practice and Implications of COVID-19 Pandemic: Recommendations by IADVL SIG Dermatosurgery (IADVL Academy) date: 2020-05-10 words: 1927 flesch: 56 summary: If possible, room for suspected COVID-19 patients should be different from those for other emergent surgical patients. If possible, preoperative assessment of surgical patients should ideally include COVID-19 testing. keywords: care; covid-19; need; patient; staff; use cache: cord-325793-5vrr7msw.txt plain text: cord-325793-5vrr7msw.txt item: #2191 of 2876 id: cord-325863-3t73v4ng author: Foss, Francine M. title: Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant patient on Ruxolitinib date: 2020-06-25 words: 1991 flesch: 37 summary: Recommendations on how to manage immunosuppression agents in allogeneic transplant patients who are infected with SARS CoV-2 have not been clearly established. We recently diagnosed COVID19 infection in a patient who was on oral ruxolitinib for management of graft-vs-host disease after allogeneic stem cell transplant and report on his presentation and the evolution of his clinical course. keywords: cell; coronavirus; disease; ruxolitinib; sars; stem cache: cord-325863-3t73v4ng.txt plain text: cord-325863-3t73v4ng.txt item: #2192 of 2876 id: cord-325869-3mvjc805 author: Silvestris, Nicola title: A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave? date: 2020-06-11 words: 2466 flesch: 37 summary: The systematic collection of well-annotated biological samples from COVID-19 infected cancer patients is an essential part of our proposal. key: cord-325869-3mvjc805 authors: Silvestris, Nicola; Apolone, Giovanni; Botti, Gerardo; Ciliberto, Gennaro; Costantini, Massimo; De Paoli, Paolo; Franceschi, Silvia; Opocher, Giuseppe; Paradiso, Angelo; Pronzato, Paolo; Sgambato, Alessandro; De Maria, Ruggero title: A moonshot approach toward the management of cancer patients in the COVID-19 time: what have we learned and what could the Italian network of cancer centers (Alliance Against Cancer, ACC) do after the pandemic wave? date: 2020-06-11 journal: keywords: cancer; covid-19; data; infection; italy; patients; research cache: cord-325869-3mvjc805.txt plain text: cord-325869-3mvjc805.txt item: #2193 of 2876 id: cord-325933-1qvpofvp author: Samrah, Shaher M title: Depression and Coping Among COVID-19-Infected Individuals After 10 Days of Mandatory in-Hospital Quarantine, Irbid, Jordan date: 2020-10-06 words: 3514 flesch: 42 summary: Symptoms of depression were common among both symptomatic and asymptomatic quarantined COVID-19 patients. Although variable degrees of fear, anxiety, anger, and depression are suspected to be observed in COVID-19-infected population during their quarantine, most studies in the literature focused on the psychosocial disturbances among health-care providers and potential contacts of COVID-19 patients. keywords: care; covid-19; depression; health; patients; quarantine; study; symptoms cache: cord-325933-1qvpofvp.txt plain text: cord-325933-1qvpofvp.txt item: #2194 of 2876 id: cord-325963-d0hvukbu author: Faes, Christel title: Time between Symptom Onset, Hospitalisation and Recovery or Death: Statistical Analysis of Belgian COVID-19 Patients date: 2020-10-17 words: 5591 flesch: 52 summary: There are different patterns in the COVID-19 outbreak in the general population and amongst nursing home patients. But, while the LoS in hospital for patients that recover increases with age for all age groups, the survival time of hospitalized patients that died is lower for the age groups seniors (median time of 6.7 days) and elderly (median time of 5.7 days) as compared to the working age group (median time of 12.1 days). keywords: age; days; hospital; onset; patients; symptom; time cache: cord-325963-d0hvukbu.txt plain text: cord-325963-d0hvukbu.txt item: #2195 of 2876 id: cord-325970-ivtunxrd author: Yerramilli, Divya title: Palliative Radiotherapy for Oncologic Emergencies in the setting of COVID-19: Approaches to Balancing Risks and Benefits date: 2020-04-08 words: 2726 flesch: 21 summary: Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial A predictive model for survival in metastatic cancer patients attending an outpatient palliative radiotherapy clinic Predicting life expectancy in patients with metastatic cancer receiving palliative radiotherapy: the TEACHH model Refining the TEACHH Model: Towards Improved Clinical Utility in the Modern Era How to Protect Yourself COVID-19) Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: Final results of the first two studies by the radiation therapy oncology group A new scoring system to predicting the survival of patients treated with whole-brain radiotherapy for brain metastases Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. Recent data from China and Italy have demonstrated that cancer patients have a higher risk of contracting the virus, as well as a higher case-fatality rate (9) (10) (11) (12) . keywords: cancer; palliative; patients; radiation; radiotherapy; treatment cache: cord-325970-ivtunxrd.txt plain text: cord-325970-ivtunxrd.txt item: #2196 of 2876 id: cord-325971-volbaipv author: Neupane, Karun title: Potential Treatment Options for COVID-19: A Comprehensive Review of Global Pharmacological Development Efforts date: 2020-06-26 words: 3026 flesch: 40 summary: Several drugs are being tested in the trials, and the United States Food and Drugs Administration (FDA) has given Emergency Use Authorization (EUA) for remdesivir to treat COVID-19 patients on May 1, 2020 The clinical management of COVID-19 patients is focused on alleviating clinical symptoms by general and symptom-specific supportive care keywords: coronavirus; covid-19; patients; remdesivir; results; sars; treatment; trials cache: cord-325971-volbaipv.txt plain text: cord-325971-volbaipv.txt item: #2197 of 2876 id: cord-326017-qw4qynqv author: Laskar, Partha title: “Tomorrow Never Dies”: Recent Advances in Diagnosis, Treatment, and Prevention Modalities against Coronavirus (COVID-19) amid Controversies date: 2020-08-06 words: 14817 flesch: 35 summary: Thus, early, rapid, and accurate diagnosis of COVID-19 patients is becoming very crucial to control the sources of infection and to prevent further community spread. Such tests have proven lung histology (lung damage or holes/honeycomb-like appearance) of COVID-19 patients [70] . keywords: 2019; amplification; antiviral; cases; coronavirus; cov-2; covid-19; data; detection; development; disease; drug; health; human; iii; infection; methods; number; pandemic; patients; pcr; pneumonia; research; rna; sars; time; treatment; use cache: cord-326017-qw4qynqv.txt plain text: cord-326017-qw4qynqv.txt item: #2198 of 2876 id: cord-326023-vwukiwe4 author: Leung, Char title: Risk factors for predicting mortality in elderly patients with COVID-19: a review of clinical data in China date: 2020-04-27 words: 2688 flesch: 47 summary: While dyspnoea and chest pain/discomfort were more commonly seen in deceased patients as they represented severe pneumonia, fever was more prominent in surviving patients. Two searches were performed, one with the search terms death, pneumonia and age for the clinical data of deceased patients whereas the other with the search terms discharge, pneumonia and age for the clinical data of surviving patients that served as controls. keywords: clinical; covid-19; mortality; patients; study cache: cord-326023-vwukiwe4.txt plain text: cord-326023-vwukiwe4.txt item: #2199 of 2876 id: cord-326185-gjte739i author: Mukherjee, Pratik title: Adaptability and responsiveness: keys to operational measures in a regional hospital radiology department during the current COVID-19 pandemic date: 2020-06-19 words: 6159 flesch: 46 summary: Internet Walk-Up X-ray Booth Offers Quick Scans to COVID-19 Patients Additional staff (radiologists, radiographers, nurses and other radiology department support staff) were rostered over the weekends to clear the extra workload. keywords: cases; covid-19; department; disease; hospital; infection; pandemic; patients; radiology; singapore; staff cache: cord-326185-gjte739i.txt plain text: cord-326185-gjte739i.txt item: #2200 of 2876 id: cord-326272-ya3r0h1t author: Dobesh, Paul P. title: Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID‐19 date: 2020-10-01 words: 8611 flesch: 41 summary: All rights reserved There have also been observational trials that have compared rates of VTE in COVID-19 patients to historical controls without COVID-19 (Table 3) . The rate of PE was 3-fold higher in COVID-19 patients compared to those without, but was also more than 2-fold higher than influenza patients specifically during the same time frame. keywords: anticoagulation; article; coronavirus; covid-19; dimer; disease; icu; patients; prophylaxis; risk; sars; thrombosis; venous; vte cache: cord-326272-ya3r0h1t.txt plain text: cord-326272-ya3r0h1t.txt item: #2201 of 2876 id: cord-326354-fhafg41x author: Pesavento, Raffaele title: The hazard of (sub)therapeutic doses of anticoagulants in non‐critically ill patients with Covid‐19: the Padua province experience date: 2020-07-21 words: 2836 flesch: 36 summary: All rights reserved Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance A Novel Coronavirus from Patients with Pneumonia in China A novel coronavirus outbreak of global health concern Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-Accepted Article This article is protected by copyright. The results of prospective randomized studies, including severe patients, are warranted. keywords: antithrombotic; bleeding; covid-19; doses; patients; study cache: cord-326354-fhafg41x.txt plain text: cord-326354-fhafg41x.txt item: #2202 of 2876 id: cord-326468-xcy7v1tf author: Mehta, R. M. title: A shorter symptom-onset to remdesivir treatment (SORT) interval is associated with a lower mortality in moderate-to-severe COVID-19: A real-world analysis date: 2020-11-10 words: 3701 flesch: 47 summary: Although not statistically significant, the median LOHS was numerically lower in patients with SORT interval ≤9 days compared with >9 days (10 v 12 days; P = .34). Patients with SORT interval ≤9 days showed favorable outcomes with lower mortality (18.1% vs 33.7%) compared with SORT interval >9 days, with the difference driven largely by the severe subset. keywords: covid-19; days; interval; mortality; patients; remdesivir; sort cache: cord-326468-xcy7v1tf.txt plain text: cord-326468-xcy7v1tf.txt item: #2203 of 2876 id: cord-326643-obfvi3ms author: Lo Giudice, Roberto title: The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) in Dentistry. Management of Biological Risk in Dental Practice date: 2020-04-28 words: 4580 flesch: 52 summary: Especially when treating in urgent situations or emergencies during the virus pandemic [6] , clinicians should not underestimate the possibility of infection from asymptomatic patients, and all dental treatment should be considered high-risk. This paper aims to discuss and suggest the most appropriate procedures in every aspect of dental practice to reduce infection risk. keywords: contact; droplets; infection; patient; risk; sars; use; virus cache: cord-326643-obfvi3ms.txt plain text: cord-326643-obfvi3ms.txt item: #2204 of 2876 id: cord-326703-akn92p1r author: Bartoletti, Michele title: Development and validation of a prediction model for severe respiratory failure in hospitalized patients with SARS-Cov-2 infection: a multicenter cohort study (PREDI-CO study) date: 2020-08-08 words: 2210 flesch: 48 summary: 319 To conclude, we developed and validated an individual risk score including eight strong predictors 320 of SRF to identify at hospital admission patients with COVID-19 diagnosis deserving a high level of 321 care and a prompt medical treatment. mg/dl, and LDH ≥350 IU/L. Our model and risk score performed 281 similarly even in different cohorts, as defined by different hospitals, providing independent 282 validation. keywords: cohort; patients; risk; score; srf; validation cache: cord-326703-akn92p1r.txt plain text: cord-326703-akn92p1r.txt item: #2205 of 2876 id: cord-326747-zwp13awk author: Sever, Mustafa title: Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date: 2009-12-28 words: 3977 flesch: 49 summary: All hospitals' emergency departments (ED) medical records which explain above were retrospectively analyzed for evaluation of accidental chlorine exposure patients for year 2007. The respiratory system is the most adversely affected of all organ systems by chlorine gas exposure [11] and complications are generally immediate with severe exposure, including acute respiratory distress syndrome (ARDS), respiratory failure, pneumomediastinum and death keywords: chlorine; exposure; gas; group; patients; treatment cache: cord-326747-zwp13awk.txt plain text: cord-326747-zwp13awk.txt item: #2206 of 2876 id: cord-326751-fn43p19j author: Herold, Christian J. title: Community-acquired and nosocomial pneumonia date: 2004-01-29 words: 8606 flesch: 31 summary: The patient was diagnosed to have E. coli pneumonia Fig. Diffuse interstitial pneumonias are most commonly caused by viruses and protozoa, and are rarely seen in bacterial pneumonias. keywords: acute; air; cap; chest; diagnosis; disease; fig; infection; lung; patients; pneumonia; pulmonary cache: cord-326751-fn43p19j.txt plain text: cord-326751-fn43p19j.txt item: #2207 of 2876 id: cord-326752-45ckkv01 author: Barnett, Brian title: Keeping the wolf at bay: Infection prevention and control measures for inpatient psychiatric facilities in the time of COVID-19 date: 2020-07-12 words: 1250 flesch: 29 summary: Due to cognitive limitations and severe mental illness, many patients also struggle with attending to activities of daily living, such as bathing and hand hygiene [11, 12] . Patients are frequently admitted to psychiatric facilities directly from areas at high risk for COVID-19 dissemination, such as hospitals, correctional facilities, nursing homes, emergency rooms and homeless shelters. keywords: covid-19; patients cache: cord-326752-45ckkv01.txt plain text: cord-326752-45ckkv01.txt item: #2208 of 2876 id: cord-326785-le2t1l8g author: None title: Pathological Society of Great Britain and Ireland. 163rd meeting, 3–5 July 1991 date: 2005-06-15 words: 22778 flesch: 36 summary: SSCs in the Connective tissue were Melled with the antibody along With a number of other cells (lymphocytes) within the germinal centres. These results show that sadium iodoacetate reduces cell number and interferes wqth the manufacture of matrix components. keywords: acp; adhesion; age; analysis; antibodies; antibody; antigen; areas; associated; benign; biopsies; biopsy; bone; breast; carcinoma; cases; cells; changes; chronic; common; day; days; diagnosis; disease; distribution; dna; electron; epithelium; evidence; expression; features; formation; gene; grade; group; high; hpv; human; increase; inflammatory; kidney; lesions; light; lor; low; lung; malignant; material; mean; microscopy; model; muscle; negative; non; normal; number; paraffin; pathology; patients; present; protein; range; renal; response; results; sections; specimens; staining; study; system; technique; thought; time; tissue; treatment; tumour; turnours; type; wlth; years cache: cord-326785-le2t1l8g.txt plain text: cord-326785-le2t1l8g.txt item: #2209 of 2876 id: cord-326807-dii4u9gj author: Kow, Chia Siang title: Use of low-molecular-weight heparin in COVID-19 patients date: 2020-06-17 words: 252 flesch: 29 summary: Higher than traditional, 2 standard prophylactic dose of LMWH as adopted in authors' institution should be encouraged Higher-than-usual rate of thromboprophylaxis failure may be due to an increasingly recognized Upsurge of deep venous thrombosis in patients affected by COVID-4 19: Preliminary data and possible explanations Incidence of venous thromboembolism in 7 hospitalized patients with COVID-19 The procoagulant pattern of patients with COVID-10 19 acute respiratory distress syndrome Hypercoagulability of COVID-19 patients in 13 Intensive Care Unit. According to the authors, administration of anticoagulant doses of low-molecular-weight heparin 20 (LMWH) in hospitalized COVID-19 patients, instead of prophylactic doses, was the current practice in their institution. keywords: covid-19 cache: cord-326807-dii4u9gj.txt plain text: cord-326807-dii4u9gj.txt item: #2210 of 2876 id: cord-326834-eeldyj2u author: Graziani, Desirée title: Characteristics and Prognosis of COVID-19 in Patients with COPD date: 2020-10-12 words: 4371 flesch: 40 summary: The demographic and clinical characteristics of COVID-19 patients with and without COPD are shown in Table 1 . The demographic and clinical characteristics of COVID-19 patients with and without COPD are shown in Table 1 . keywords: copd; covid-19; data; disease; mortality; patients; population; study cache: cord-326834-eeldyj2u.txt plain text: cord-326834-eeldyj2u.txt item: #2211 of 2876 id: cord-326851-0jxdnm1l author: Lee, Sang M. title: Lessons Learned from Battling COVID-19: The Korean Experience date: 2020-10-16 words: 9670 flesch: 46 summary: This study attempts to present directions for potential changes in the crisis response systems of public healthcare worldwide, by analyzing COVID-19 pandemic response cases, both successes and failures, in Korea. On 10 March 2020, the Korean government established residential treatment centers to treat confirmed COVID-19 patients while maintaining their quarantine. keywords: cases; covid-19; covid-19 pandemic; crisis; daegu; government; healthcare; hospital; infection; korea; pandemic; patients; people; public; response; spread; system; virus cache: cord-326851-0jxdnm1l.txt plain text: cord-326851-0jxdnm1l.txt item: #2212 of 2876 id: cord-326883-j7pbe50g author: Stöbe, Stephan title: Echocardiographic characteristics of patients with SARS-CoV-2 infection date: 2020-08-14 words: 4854 flesch: 32 summary: Tagging images (s-v) of apical (s, t) and basal SAX (u, v) document abnormal basal rotation Table 3 Analyses of myocardial rotational LV deformation in a control group of healthy individuals (n = 20) Mean values of radial and circumferential strain as well as rotation of the apical and basal LV segments are shown: global radial strain of apical LV segments (GRS apical), apical rotation, global circumferential strain of apical LV segments (GCS apical), global radial strain of basal LV segments (GRS basal), basal rotation, and global circumferential strain of basal LV segments (GCS basal) Additional findings included a biphasic pattern with maximum post-systolic or negative regional radial strain predominantly basal (n = 5/14 patients, 36%); the absence or dispersion of basal LV rotation (n = 6/14 patients, 43%); a reduced or positive regional circumferential strain in more than one segment (n = 7/14 patients, 50%); a net rotation showing late post-systolic twist or biphasic pattern (n = 8/14 patients, 57%); a net rotation showing polyphasic pattern and/or higher maximum net values during diastole (n = 8/14 patients, 57%). keywords: basal; cov-2; deformation; patients; rotation; sars; segments; strain cache: cord-326883-j7pbe50g.txt plain text: cord-326883-j7pbe50g.txt item: #2213 of 2876 id: cord-326984-o27rp468 author: CHIEN, Jung‐Yien title: Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome date: 2006-10-16 words: 3574 flesch: 45 summary: Therefore, even though IL-6 concentrations were lower in SARS patients than in CAP patients, it still appeared to be an important element of the pathogenesis of lung injury in SARS. The mean ratio of IL‐6 to IL‐10 in SARS patients (4.84; range 0.41–21) was significantly higher than that in CAP patients (2.95; range 0.02–10.57) (P = 0.04). keywords: cap; chemokine; cytokine; levels; lung; patients; sars; syndrome cache: cord-326984-o27rp468.txt plain text: cord-326984-o27rp468.txt item: #2214 of 2876 id: cord-326991-m0lfk0a9 author: Nuñez, Jorge H. title: Rethinking Trauma Hospital Services in one of Spain's Largest University Hospitals during the COVID-19 pandemic. How can we organize and help? Our experience. date: 2020-09-25 words: 4020 flesch: 52 summary: Daily telematics-obtained information on the status of COVID-19 positive patients is vital. At the beginning of the first week, healthcare personnel only used surgical masks in the hospital, and we only tested emergency room patients who reported symptoms. keywords: covid-19; emergency; healthcare; hospital; pandemic; patients; surgeries; trauma cache: cord-326991-m0lfk0a9.txt plain text: cord-326991-m0lfk0a9.txt item: #2215 of 2876 id: cord-326994-y8p724s4 author: Mohamad, Osama title: Delaying Dilemmas: Coronavirus Complications Impacting the Management of Prostate Cancer date: 2020-10-01 words: 342 flesch: 61 summary: after lengthy discussions regarding reasonable and safe delays for UIR patients, 2 the patient elected to delay SBRT due to his concerns about viral exposure. What is your recommended fractionation for UIR patients? 2. keywords: patient; prostate cache: cord-326994-y8p724s4.txt plain text: cord-326994-y8p724s4.txt item: #2216 of 2876 id: cord-327017-b2refzfw author: Elbeddini, Ali title: Pharmacist intervention amid the coronavirus disease 2019 (COVID-19) pandemic: from direct patient care to telemedicine date: 2020-05-27 words: 1627 flesch: 45 summary: key: cord-327017-b2refzfw authors: Elbeddini, Ali; Yeats, Aniko title: Pharmacist intervention amid the coronavirus disease 2019 (COVID-19) pandemic: from direct patient care to telemedicine date: 2020-05-27 journal: J Pharm Policy Pract DOI: 10.1186/s40545-020-00229-z sha: doc_id: 327017 cord_uid: b2refzfw The coronavirus disease (COVID-19) pandemic has placed enormous pressures on the Canadian healthcare system. Fortunately, many pharmacy services can be delivered over the phone, but the question arises about whether the quality of care by virtual means is on par with that of direct patient care. keywords: care; covid-19; pandemic; patients cache: cord-327017-b2refzfw.txt plain text: cord-327017-b2refzfw.txt item: #2217 of 2876 id: cord-327125-86ocr70d author: Iehara, Tomoko title: Statement on the prevention and treatment of COVID‐19 in patients with pediatric cancer in Japan date: 2020-06-22 words: 318 flesch: 40 summary: Clinical features of patients infected with 2019 novel coronavirus in Wuhan SARS-CoV-2 infection in children Clinical and epidemiological features of 36 children China: an observational cohort study Challenges posed by COVID-19 to children with cancer Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2 2, 3 Three of 171 cases of pediatric infections in Wuhan required intensive care including ventilator use and one of these cases was a leukemia patient undergoing maintenance therapy. keywords: patients cache: cord-327125-86ocr70d.txt plain text: cord-327125-86ocr70d.txt item: #2218 of 2876 id: cord-327148-dzozl70h author: Tahmassebi, Ramon title: Reflections from London’s Level-1 Major Trauma Centres during the COVID crisis date: 2020-06-26 words: 2477 flesch: 40 summary: Predictably, many patients could be willingly postponed or even discharged by telephone, seemingly confirming that traditional practice around out-patient follow-up is outdated and open to modernisation [12] . We describe the impact of this on the provision of major trauma care in a major capital city. keywords: care; covid-19; hospital; pandemic; patient; staff; surgery; trauma cache: cord-327148-dzozl70h.txt plain text: cord-327148-dzozl70h.txt item: #2219 of 2876 id: cord-327165-vlyfbiem author: Montorfano, Lisandro title: Colorectal surgery obesity-related morbidity during COVID-19 date: 2020-07-09 words: 2362 flesch: 37 summary: The disease has rapidly spread around the world and has been acknowledged as an international public health emergency because of a lack of sufficient resources to care for the increasing number of patients with acute respiratory distress syndrome due to COVID-19 One of the most commonly reported complications of Tocilizumab in patients with rheumatologic conditions is the increased risk of lower gastrointestinal perforations. keywords: bowel; care; coronavirus; covid-19; patients; perforation; tocilizumab cache: cord-327165-vlyfbiem.txt plain text: cord-327165-vlyfbiem.txt item: #2220 of 2876 id: cord-327214-kcbxyhhh author: Eketunde, Adenike O title: A Review of Postmortem Findings in Patients With COVID-19 date: 2020-07-28 words: 2733 flesch: 38 summary: There is a strong association with the hyperinflammatory state, which can be explained by most of the signs and symptoms that are exhibited by COVID-19 patients, including most of the pathological findings. According to Merad and Martin's study, the hyper inflammation in severe COVID-19 patients shared similarities with cytokine release syndromes, including macrophages activation syndrome. keywords: coronavirus; covid-19; disease; findings; macrophages; patients; sars cache: cord-327214-kcbxyhhh.txt plain text: cord-327214-kcbxyhhh.txt item: #2221 of 2876 id: cord-327349-rxb6zfoc author: Au, Lewis title: Cancer, COVID-19, and antiviral immunity: the CAPTURE study date: 2020-09-03 words: 4534 flesch: 25 summary: key: cord-327349-rxb6zfoc authors: Au, Lewis; Boos, Laura Amanda; Swerdlow, Anthony; Byrne, Fiona; Shepherd, Scott T.C.; Fendler, Annika; Turajlic, Samra title: Cancer, COVID-19, and antiviral immunity: the CAPTURE study date: 2020-09-03 journal: Cell DOI: 10.1016/j.cell.2020.09.005 sha: doc_id: 327349 cord_uid: rxb6zfoc The SARS-CoV-2 pandemic has posed a significant challenge for risk evaluation and mitigation amongst cancer patients. Susceptibility to and severity of COVID-19 in cancer patients has not been studied in a prospective and broadly applicable manner. keywords: cancer; capture; cov-2; covid-19; immune; infection; outcomes; patients; response; risk; sars; study cache: cord-327349-rxb6zfoc.txt plain text: cord-327349-rxb6zfoc.txt item: #2222 of 2876 id: cord-327370-zo0n8wf6 author: Vadukul, Prakash title: Massive pulmonary embolism following recovery from COVID-19 infection: inflammation, thrombosis and the role of extended thromboprophylaxis date: 2020-09-13 words: 3120 flesch: 34 summary: COVID-19 infection: origin, transmission, and characteristics of human coronaviruses Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Facing COVID-19 in the ICU: vascular dysfunction, thrombosis, and dysregulated inflammation Blood coagulation in immunothrombosis-At the frontline of intravascular immunity Coagulation abnormalities and thrombosis in patients with COVID-19 Interleukin 6 and haemostasis Interleukin 6 regulates psoriasiform inflammationassociated thrombosis Interleukin-6 in COVID-19: a systematic review and metaanalysis SARS-CoV-2 and COVID-19: Is interleukin-6 (IL-6) the 'culprit lesion' of ARDS onset? key: cord-327370-zo0n8wf6 authors: Vadukul, Prakash; Sharma, Deepak S; Vincent, Paul title: Massive pulmonary embolism following recovery from COVID-19 infection: inflammation, thrombosis and the role of extended thromboprophylaxis date: 2020-09-13 journal: BMJ Case Rep DOI: 10.1136/bcr-2020-238168 sha: doc_id: 327370 cord_uid: zo0n8wf6 COVID-19 is the infectious disease caused by a recently discovered SARS-CoV-2. keywords: care; covid-19; disease; infection; patients; risk; thrombosis; vte cache: cord-327370-zo0n8wf6.txt plain text: cord-327370-zo0n8wf6.txt item: #2223 of 2876 id: cord-327397-8rxjju0t author: Zhang, H.-Y. title: A Multicentre Study of 2019 Novel Coronavirus Disease Outcomes of Cancer Patients in Wuhan, China date: 2020-03-26 words: 3507 flesch: 53 summary: In this multicentre retrospective study, we reported the largest cohort of cancer patients with of COVID-19 patients develop ARDS, 7 while the incidence rate of ARDS in our cancer cohort was 16.42%. Two previous case series from China have suggested that cancer patients are at a higher risk of COVID-19 pneumonia, but the reports were limited by small numbers and few clinical information. keywords: cancer; covid-19; license; patients; preprint; treatment cache: cord-327397-8rxjju0t.txt plain text: cord-327397-8rxjju0t.txt item: #2224 of 2876 id: cord-327413-zdbnoy1q author: Bendjelid, Karim title: Hemodynamic monitoring of Covid-19 patients. Classical methods and new paradigms date: 2020-09-04 words: 1314 flesch: 31 summary: Interestingly, when analysing the data, the authors found that the majority of COVID-19 ICU patients required vasopressor support, with certain changes in cardiac function patterns warranting echocardiographic monitoring. Indeed, the key information to know regarding vasopressor requirements in COVID-19 ICU patients is the mean dose used. keywords: care; covid-19; monitoring; patients cache: cord-327413-zdbnoy1q.txt plain text: cord-327413-zdbnoy1q.txt item: #2225 of 2876 id: cord-327415-nu1msnui author: Kadiane-Oussou, N’dri Juliette title: COVID-19: comparative clinical features and outcome in 114 patients with or without pneumonia (Nord Franche-Comte Hospital, France) date: 2020-10-10 words: 1732 flesch: 51 summary: In a recent published 140 article, we suggested that neurologic symptoms in COVID-19 were more frequently described in Patients with COVID-19 pneumonia are usually hospitalized for observation and supportive care (13) 154 (in our study, 95% of patients in group P were hospitalized). Patients with 156 COVID-19 pneumonia may become critically ill; more than a fifth of patients in group P were 157 transferred to ICU for ARDS with a mean duration of hospitalization in ICU of 12 days and a high 158 lethality as compared to the mortality described in China (7). keywords: covid-19; group; patients; pneumonia cache: cord-327415-nu1msnui.txt plain text: cord-327415-nu1msnui.txt item: #2226 of 2876 id: cord-327432-ogw27tob author: Zhang, Feng-jian title: Expert Consensus on Nurses’ Human Caring for COVID-19 Patients in Different Sites date: 2020-08-07 words: 3322 flesch: 34 summary: Patients with common fever, suspected infection, and confirmed COVID-19 infection, should be classified and managed in different ways by following guidelines; (10) Assess the basic needs of patients, and provide warm food and warm water according to their needs. Invite the psychologist or relevant specialist to intervene for severe psychological problems; (7) Assist patients in arranging further consultation and other matters; (8) Record the patient's special problems or conditions for other healthcare workers to pay attention to in future follow-up; (9) Provide necessary assistance for patients to return to their work; (1) Receive patient forwardly and warmly with polite manner and moderate voice, and introduce the name and role to the patients; (2) Keep the clinic area spacious, and decorate the area with clear signs, warm colors, green plants, and positive energy posters; (3) Design a quick physical examination process, guide the recovered person to finish the examination at different times. keywords: caring; covid-19; health; human; needs; patients; treatment cache: cord-327432-ogw27tob.txt plain text: cord-327432-ogw27tob.txt item: #2227 of 2876 id: cord-327442-e02y93f6 author: Kastritis, Efstathios title: Systemic autoimmune diseases, anti-rheumatic therapies, COVID-19 infection risk and patient outcomes date: 2020-07-11 words: 4050 flesch: 32 summary: Treatment adherence of patients with systemic rheumatic diseases in COVID-19 pandemic COVID-19, rheumatic diseases and immunosuppressive drugs: an appeal for medication adherence Coronavirus disease 2019 (COVID-19) and anti-rheumatic drugs Virusassociated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A (H1N1) infection Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus COVID-19: a new virus, but a familiar receptor and cytokine release Syndrome The many faces of the anti-COVID immune response Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China Current concepts in the diagnosis and management of cytokine release syndrome Recommendations for the management of hemophagocytic lymphohistiocytosis in adults On the alert for cytokine storm: immunopathology in COVID-19 Immunosuppression for hyperinflammation in COVID-19: a double-edged sword? Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis Risk factors for reported influenza and influenza-like symptoms in patients with rheumatoid arthritis Greek Rheumatology Society and Professional Association of Rheumatologists (ERE-EPERE) (2020) Recommendations regarding COVID-19 infection in rheumatic patients in Greece Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia Scarpellini P, Dagna L (2020) Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Effective treatment of severe COVID-19 patients with tocilizumab Favorable Anakinra responses in severe COVID-19 patients with secondary hemophagocytic lymphohistiocytosis Baricitinib for COVID-19: a suitable treatment? Baricitinib as potential treatment for 2019-nCoV acute respiratory disease COVID-19: combining antiviral and antiinflammatory treatments Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a 6-day follow up: a pilot observational study Observational study of hydroxychloroquine in hospitalized patients with Covid-19 A rush to judgment? Clinical course of COVID-19 in a series of patients with chronic arthritis treated with immunosuppressive targeted therapies Rheumatic disease and COVID-19: initial data from the COVID-19 Global Rheumatology Alliance provider registries Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physicianreported registry Incidence and clinical course of COVID-19 in patients with connective tissue diseases: a descriptive observational analysis Rituximab for granulomatosis with polyangiitis in the pandemic of covid-19: lessons from a case with severe pneumonia A (2020) Identifying rheumatic disease patients at high risk and requiring shielding during the COVID-19 pandemic WHO Coronavirus Disease Geoepidemiology of autoimmune rheumatic diseases COVID-19 pandemic: is a gender-defined dosage effect responsible for the high mortality rate among males Conflict of interest None for this manuscript, for all authors. keywords: anti; covid-19; data; diseases; hydroxychloroquine; infection; patients; risk cache: cord-327442-e02y93f6.txt plain text: cord-327442-e02y93f6.txt item: #2228 of 2876 id: cord-327481-m9r0p84v author: Duployez, Nicolas title: Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19 date: 2020-07-21 words: 3867 flesch: 40 summary: Serum profiling of COVID-19 patients has revealed a distinct inflammatory response characterized by high levels of interleukin-6 (IL-6) and reduced type I interferon Overall, mutations in DNMT3A and/or TET2 were present in 36% (44/122) of COVID-19 patients and were found in 80% (44/55) of those with CH. keywords: cohort; covid-19; hematopoiesis; mutations; patients; tet2; years cache: cord-327481-m9r0p84v.txt plain text: cord-327481-m9r0p84v.txt item: #2229 of 2876 id: cord-327545-y3vejwtr author: Shannon, Vickie R. title: Multinational Association of Supportive Care in Cancer (MASCC) 2020 clinical practice recommendations for the management of immune-related adverse events: pulmonary toxicity date: 2020-09-03 words: 5725 flesch: 28 summary: The relative risk and incidence of immune checkpoint inhibitors related pneumonitis in patients with advanced cancer: a meta-analysis Incidence of programmed cell death 1 inhibitor-related pneumonitis in patients with advanced cancer: a systematic review and meta-analysis Programmed death-1/programmed death ligand-1 inhibitor-related pneumonitis and radiographic patterns PD-1 inhibitor-related pneumonitis in advanced cancer patients: radiographic patterns and clinical course Pneumotoxicity associated with immune checkpoint inhibitor therapies Recurrent pleural effusions and cardiac tamponade as possible manifestations of pseudoprogression associated with nivolumab therapy-a report of two cases Rapid granulomatosis with polyangiitis induced by immune checkpoint inhibition Case report of ipilimumab-induced diffuse, nonnecrotizing granulomatous lymphadenitis and granulomatous vasculitis Sarcoidosis-like reactions induced by checkpoint inhibitors Systemic sarcoidosis first manifesting in a tattoo in the setting of immune checkpoint inhibition Sarcoid-Like Granulomatosis of the lung related to immunecheckpoint inhibitors: distinct clinical and imaging features of a unique immune-related adverse event Pembrolizumab in patients with advanced nonsmall-cell lung cancer (KEYNOTE-001): 3-year results from an open-label, phase 1 study Risk of pneumonitis associated with programmed cell death 1 inhibitors in cancer patients: a meta-analysis Safety and tolerability of PD-1/PD-L1 inhibitors compared with chemotherapy in patients with advanced cancer: a meta-analysis Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial Incidence of pneumonitis with use of programmed death 1 and programmed death-ligand 1 inhibitors in non-small cell lung cancer: a systematic review and meta-analysis of trials Nivolumab and ipilimumab versus ipilimumab in untreated melanoma Nivolumab in previously untreated melanoma without BRAF mutation Diagnosis, monitoring and management of immune-related adverse drug reactions of anti-PD-1 antibody therapy Combined immune checkpoint blockade (anti-PD-1/anti-CTLA-4): evaluation and management of adverse drug reactions PD-1 blockade expands intratumoral memory t cells Targeting tumor-infiltrating macrophages decreases tumorinitiating cells, relieves immunosuppression, and improves chemotherapeutic responses PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: a systematic analysis of the literature Overall survival (OS) and safety results from a phase 3 trial of ipilimumab (IP) at 3 mg/kg vs 10 mg/kg in patients with metastatic melanoma (MEL) KEYNOTE-001 Investigators (2015) Pembrolizumab for the treatment of non-small-cell lung cancer Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features Relationship between prior radiotherapy and checkpoint-inhibitor pneumonitis in patients with advanced nonsmall-cell lung cancer Immune-checkpoint inhibitors associated with interstitial lung disease in cancer patients Use of immune checkpoint inhibitors in the treatment of patients with cancer and preexisting autoimmune disease Use of immune checkpoint inhibitors in the treatment of patients with cancer and preexisting autoimmune disease Immune checkpoint inhibitor therapy in patients with autoimmune disease Significant risk of graft-versus-host disease with exposure to checkpoint inhibitors before and after allogeneic transplantation Fatal graft-versus-host disease after allogeneic stem cell transplantation in a patient recently exposed to nivolumab Immune checkpointbased therapy in myeloid malignancies: a promise yet to be fulfilled PD-1/ PD-L1 inhibitors in haematological malignancies: update 2017 Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial Immune checkpoint inhibitors in challenging populations Pre-existing autoimmune disease and the risk of immunerelated adverse events among patients receiving checkpoint inhibitors for cancer Pulmonary sarcoid-like granulomatosis induced by ipilimumab Peripheral lung cancer: Existing tumor burden in the lung, prior lung irradiation, and co-morbidities, such as COPD among lung cancer patients, may limit the lung's tolerance to additional injury and explain the higher rates of pneumonitis in this group of patients [33, 34] . keywords: cancer; cell; checkpoint; disease; grade; ici; immune; inhibitors; lung; patients; pd-1; pneumonitis; therapy cache: cord-327545-y3vejwtr.txt plain text: cord-327545-y3vejwtr.txt item: #2230 of 2876 id: cord-327577-c0d09cyk author: Zamora, Alberto title: Heart failure, zip code, and telemetry: a trinomial in need of understanding date: 2020-08-31 words: 1784 flesch: 39 summary: A ran-domised, controlled, parallel-group, unmasked trial Is telehealthcare for heart failure patients cost-effective? The growing number of cuttingedge treatments and technologies for advanced heart failure offer more options than ever before which is why early diagnosis of these patients is important so as to avoid reaching an optimum therapeutic option too late and also to assess when the patient would be a candidate for palliative care programmes to improve their quality of life. keywords: care; chf; failure; heart; patients; population cache: cord-327577-c0d09cyk.txt plain text: cord-327577-c0d09cyk.txt item: #2231 of 2876 id: cord-327597-fgnrujsf author: Han, Susie A. title: Clinical and Ethical Considerations in Allocation of Ventilators in an Influenza Pandemic or Other Public Health Disaster: A Comparison of the 2007 and 2015 New York State Ventilator Allocation Guidelines date: 2020-07-14 words: 5101 flesch: 37 summary: Patients are not competing against other patients and a triage officer or committee is not permitted to compare patients with one another. While this policy may deter chronic care patients from going to a hospital for fear of losing ventilator access, this policy balances the need to protect vulnerable populations with the principle of treating all patients in need of a ventilator equally. keywords: care; guidelines; health; pandemic; patient; sofa; therapy; triage; ventilator cache: cord-327597-fgnrujsf.txt plain text: cord-327597-fgnrujsf.txt item: #2232 of 2876 id: cord-327609-no58ucyq author: Murkey, Jamie A. title: Hepatitis E Virus–Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing date: 2017-06-13 words: 1954 flesch: 30 summary: Validation of metagenomic next-generation sequencing tests for universal pathogen detection Neurobrucellosis: unexpected answer from metagenomic next-generation sequencing Hepatitis E virus reinfections in solid-organ-transplant recipients can evolve into chronic infections Hepatitis E virus infection among solid organ transplant recipients, the Netherlands Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants Hepatitis E virus and neurologic disorders Evidence of hepatitis E virus breaking through the blood-brain barrier and replicating in the central nervous system A cloud-compatible bioinformatics pipeline for ultrarapid pathogen identification from next-generation sequencing of clinical samples Treatment of HEV infection in patients with a solid-organ transplant and chronic hepatitis Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient Evidence of hepatitis E virus transmission by renal graft We would like to thank the patient for participating in the PDAID research study. We demonstrate the power of clinical mNGS in elucidating the cause of uncommon and unexpected infections and identify a case of chronic HEV infection most likely transmitted through the transplanted lungs the patient had received 6 years prior. keywords: chronic; hepatitis; hev; infection; patient; transplant; virus cache: cord-327609-no58ucyq.txt plain text: cord-327609-no58ucyq.txt item: #2233 of 2876 id: cord-327611-g2ssh0fk author: Ishkanian, Amy title: Clinical Conundrum: Dysphagia in a Patient with COVID-19 and Progressive Muscle Weakness date: 2020-10-31 words: 762 flesch: 42 summary: Based on repeated SLP assessments over the course of 2 weeks, the patient continued to have severe pharyngeal dysphagia with an inability to trigger a swallow or manage her secretions. Results revealed severe pharyngeal dysphagia marked by diffuse pharyngeal weakness impacting hyolaryngeal excursion, UES distention, tongue base retraction, and pharyngeal stripping wave, resulting in severe pharyngeal residue and moderate-high risk of aspiration. keywords: covid-19; dysphagia; patient cache: cord-327611-g2ssh0fk.txt plain text: cord-327611-g2ssh0fk.txt item: #2234 of 2876 id: cord-327622-ezgufe24 author: Kaur, Ramandeep title: Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19 date: 2020-09-23 words: 6338 flesch: 37 summary: Influenza Other Respir Viruses Dynamics of infectious disease transmission by inhalable respiratory droplets Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings Survival of influenza viruses on environmental surfaces Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1 High-flow nasal cannula for COVID-19 patients: low risk of bio-aerosol dispersion Dispersal of respiratory droplets with open vs closed oxygen delivery masks: implications for the transmission of severe acute respiratory syndrome Year in review 2019: high-flow nasal cannula (HFNC) oxygen therapy for adult patients High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis Use of high flow nasal therapy to treat moderate to severe hypoxemic respiratory failure in Exhaled air dispersion during high flow nasal cannula therapy versus CPAP via different masks Preliminary findings on control of dispersion of aerosols and droplets during high-velocity nasal insufflation therapy using a simple surgical mask: implications for the high-flow nasal cannula Acute febrile respiratory illness in the ICU: reducing disease transmission Expert Consensus on Preventing Nosocomial Transmission During Respiratory Care for Critically Ill Patients Infected by 2019 Novel coronavirus pneumonia Everyone with asthma should have a metered dose inhaler and a spacer Nasal high flow in management of children with status asthmaticus: a retrospective observational study Epoprostenol delivered via high flow nasal cannula for ICU subjects with severe hypoxemia comorbid with pulmonary hypertension or right heart dysfunction The clinical impact of flow titration on epoprostenol delivery via high flow nasal cannula for ICU patients with pulmonary hypertension or right ventricular dysfunction: a retrospective cohort comparison study The ratio of nasal cannula gas flow to patient inspiratory flow on trans-nasal pulmonary aerosol delivery for adults: an in vitro study Decrease the flow setting to improve trans-nasal pulmonary aerosol delivery via high-flow nasal cannula to infants and toddlers Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial Noninvasive ventilation of patients with acute respiratory distress syndrome. Influenza Other Respir Viruses Exhaled air dispersion during noninvasive ventilation via helmets and a total facemask Staff safety during emergency airway management for COVID-19 in Hong Kong Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients Emergency tracheal intubation in 202 patients with COVID-19 in Wuhan, China: lessons learnt and international expert recommendations ventilatory and intensive care Expert recommendations for tracheal intubation in critically ill patients with noval coronavirus disease Barrier enclosure during endotracheal intubation New device and technique to protect intubation operators against COVID-19 COVID-19): anesthetic concerns, including airway management and infection control High-flow nasal cannula therapy as apneic oxygenation during endotracheal intubation in critically ill patients in the intensive care unit: a systematic review and metaanalysis Mask ventilation and dispersion of exhaled air Effect of ventilator circuit changes on ventilator-associated pneumonia: a systematic review and meta-analysis Trends in tracheostomy for mechanically ventilated patients in the United States Tracheotomy in ventilated patients with COVID-19 CORONA-steps for tracheotomy in COVID-19 patients: a staff-safe method for airway management Negativepressure aerosol cover for COVID-19 tracheostomy Does endotracheal tube clamping prevent air leaks and maintain positive endexpiratory pressure during the switching of a ventilator in a patient in an intensive care unit? keywords: aerosol; air; covid-19; dispersion; filter; flow; intubation; mask; nasal; patients; respiratory; transmission; ventilation cache: cord-327622-ezgufe24.txt plain text: cord-327622-ezgufe24.txt item: #2235 of 2876 id: cord-327632-2hz94uuw author: Lv, Na title: Management of oral medicine emergencies during COVID-19: A study to develop practice guidelines date: 2020-08-07 words: 2815 flesch: 38 summary: A brief summary and discussion on the management of oral medicine patients during COVID-19 emergency are proposed as follows, focusing on remote assistance devices and classification of emergencies. key: cord-327632-2hz94uuw authors: Lv, Na; Sun, Ming; Polonowita, Ajith; Mei, Li; Guan, Guangzhao title: Management of oral medicine emergencies during COVID-19: keywords: cell; conferencing; covid-19; emergencies; management; medicine; patient; video cache: cord-327632-2hz94uuw.txt plain text: cord-327632-2hz94uuw.txt item: #2236 of 2876 id: cord-327641-hqnem2zs author: Ji, Ying-Jie title: Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone date: 2016-11-03 words: 5872 flesch: 54 summary: Multivariate analyses showed that blood viral load (P = 0.005), confusion (P = 0.010), abdominal pain (P = 0.003), conjunctivitis (P = 0.035), and vomiting (P = 0.004) were factors independently associated with the outcomes of EVD patients. Factors such as high blood viral load, confusion, abdominal pain, vomiting and conjunctivitis were associated with poor prognosis for EVD patients. keywords: age; blood; ebola; ebov; evd; hospital; patients; rate; survival; treatment; virus cache: cord-327641-hqnem2zs.txt plain text: cord-327641-hqnem2zs.txt item: #2237 of 2876 id: cord-327690-di7hfghi author: Yang, Xiaobo title: Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study date: 2020-02-24 words: 3860 flesch: 49 summary: In three previously published studies of crtically ill patients, the patient numbers were too small to summarise the characteristics and mortality of these patients with SARS-CoV-2 pneumonia. 4 Trials on remdesivir are about to recruit both mild to moderate patients (NCT04252664) and severe patients (NCT04257656) infected with SARS-CoV-2. keywords: acute; clinical; cov-2; infection; patients; pneumonia; sars cache: cord-327690-di7hfghi.txt plain text: cord-327690-di7hfghi.txt item: #2238 of 2876 id: cord-327720-m6cofbj6 author: Chakrabarti, Amitabha title: Understanding the practice of thoracic surgery during the COVID-19 pandemic date: 2020-08-11 words: 2776 flesch: 44 summary: The procedures that can be carried out in a hospital are based on the prevalence of COVID-19 patients within the hospital and availability of hospital resources. Based on the prevalence of COVID-19 patients within the hospital, availability of hospital resources, and the rate of change (in terms of increasing prevalence of infections and resource depletion), a compass statement has been introduced giving additional direction to navigate volume restriction, based on perceived risk to patients and hospital staff. keywords: covid-19; health; hospital; pandemic; patients; risk; surgery; thoracic cache: cord-327720-m6cofbj6.txt plain text: cord-327720-m6cofbj6.txt item: #2239 of 2876 id: cord-327764-4nlg26p5 author: Sun, Da-wei title: The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: a sentinel? date: 2020-05-14 words: 5153 flesch: 44 summary: Thus, it is assumed by this study that the functional damage of CD4+T cells makes COVID-19 patients susceptible to severe disease, and the excessive exhaustion of CD8+T cells impairs cellular immune response to 2019-nCoV in severe patients [27] . Importantly, it may be that the functional damage of CD4+T cells that makes COVID-19 patients susceptible to severe disease, and the excessive exhaustion of CD8+T cells that impairs cellular immune response to 2019-nCoV in severe patients according to the literature review [27] . keywords: blood; cases; cells; covid-19; disease; group; lung; patients; study; type cache: cord-327764-4nlg26p5.txt plain text: cord-327764-4nlg26p5.txt item: #2240 of 2876 id: cord-327818-1abweqko author: Kersebaum, Dilara title: The early influence of COVID-19 pandemic-associated restrictions on pain, mood, and everyday life of patients with painful polyneuropathy date: 2020-10-14 words: 5226 flesch: 43 summary: Consequently, chronic pain patients might exceptionally be affected by the pandemic due to medical concerns and the change of social life. Because the BPI User Guide does not recommend specific cutoff points, 8 we chose this categorization because the intensity 4 is usually considered to be the threshold for inclusion in pain studies. keywords: assessment; change; health; intensity; life; pain; pandemic; patients; regulations; score; study cache: cord-327818-1abweqko.txt plain text: cord-327818-1abweqko.txt item: #2241 of 2876 id: cord-327820-4bm7b934 author: Li, Ning title: Management strategies for the burn ward during COVID-19 pandemic date: 2020-04-02 words: 2479 flesch: 42 summary: This paper establishes some management strategies for burn ward based on our own experience and the Chinese national and international public health issues regarding ward management as well as the specific characteristics of the burn ward during the respiratory infectious diseases(1-2). This paper provides some strategies regarding management of burn ward during the epidemic of COVID-19 or other respiratory infectious diseases. keywords: burn; control; covid-19; infection; management; patients; ward cache: cord-327820-4bm7b934.txt plain text: cord-327820-4bm7b934.txt item: #2242 of 2876 id: cord-327827-oliw4ee5 author: Sweid, Ahmad title: Letter: Thrombotic Neurovascular Disease in COVID-19 Patients date: 2020-06-04 words: 1051 flesch: 44 summary: Unusual trends have been seen in AIS patients who are COVID-19 positive; while it is too early to establish direct causality, our preliminary data can be used to raise awareness in the population. Moreover, cerebrovascular insult was the primary manifestation of COVID-19 in patients who did not have the fulminant virus manifestations present. keywords: covid-19; occlusion; patients; sars cache: cord-327827-oliw4ee5.txt plain text: cord-327827-oliw4ee5.txt item: #2243 of 2876 id: cord-327836-6o66a4i5 author: Zuily, S title: Thrombose artérielle et veineuse au cours du COVID-19 date: 2020-08-07 words: 2180 flesch: 44 summary: Même si les caractéristiques des patients COVID-19 semblent différentes, l'absence de données scientifiques incite à adopter les mêmes attitudes médicamenteuses qu'avec les patients sans COVID-19. [2, 3] chez les patients présentant un COVID-19 nécessitant une hospitalisation et entre 17 % keywords: cours; covid-19; des; les; par; patients; pour; une cache: cord-327836-6o66a4i5.txt plain text: cord-327836-6o66a4i5.txt item: #2244 of 2876 id: cord-327961-ysatxwph author: Wang, Le title: Risk factors of 90-day rehospitalization following discharge of pediatric patients hospitalized with mycoplasma Pneumoniae pneumonia date: 2019-11-12 words: 3227 flesch: 37 summary: Because pneumonia is a complex heterogenous disease that can be caused by a variety of pathogens, 1) studying pneumonia patients with the same infectious pathogen can reduce heterogeneity, 2) exclusion of patients with underlying diseases can improve the ability to detect readmission risk factors associated with the current acute infections. There are 155 cases of single pathogen coinfection, 30 cases of two pathogens, 4 cases of 3 pathogens discharge; 2) at the index hospital stay, readmission patients manifested different characteristics; 3) co-infection with influenza A increased the risk of 90-day readmission. keywords: children; hospital; mpp; patients; pneumonia; readmission; risk; study cache: cord-327961-ysatxwph.txt plain text: cord-327961-ysatxwph.txt item: #2245 of 2876 id: cord-327989-6p39cx2e author: Everaert, Bert title: Emerging cardiological issues during the COVID‐19 pandemic date: 2020-05-16 words: 1986 flesch: 39 summary: Furthermore, the pandemic puts stress on the organization of cardiac health care, both for COVID-19 patients as well as for the acute and chronic care of cardiac patients in which patient as well as physician-related delays in treatment could potentially lead to harm. In a recent report of Shi et al. 2 hospitalized COVID-19 patients in Wuhan, China, presenting with elevated high-sensitive cardiac troponin I levels had a higher frequency of complications such as ARDS (58.5% vs. 14.7%) and acute kidney injury (8.5 vs. 0.3%), required more invasive mechanical ventilation (22% vs. 4.2%) and had a significant increase in in-hospital mortality than patients without cardiac injury (51.2% vs. 4.5%). keywords: cardiac; covid-19; disease; patients; risk cache: cord-327989-6p39cx2e.txt plain text: cord-327989-6p39cx2e.txt item: #2246 of 2876 id: cord-328039-xt17gvcp author: Olson, Michael C. title: RadioGraphics Update: Venous Thrombosis and Hypercoagulability in the Abdomen and Pelvis—Findings in COVID-19 date: 2020-07-10 words: 1628 flesch: 22 summary: Some data suggest that the hypoxia induced by COVID-19 pneumonia may result in hypoxia-reperfusion and resultant cell death. In contradistinction, some studies have shown prolonged aPTT in patients with confirmed COVID-19, often in conjunction with the presence of lupus anticoagulant antibodies. keywords: covid-19; imaging; injury; patients; thrombosis cache: cord-328039-xt17gvcp.txt plain text: cord-328039-xt17gvcp.txt item: #2247 of 2876 id: cord-328040-5qd05e4r author: Zhao, Xin-Ying title: Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study date: 2020-04-29 words: 3419 flesch: 50 summary: To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described. A considerable proportion of COVID-19 patients develop severe pneumonia, pulmonary edema, acute respiratory distress syndrome, and even multiple organ failure within a short time. keywords: cases; covid-19; disease; patients; sars; study; wuhan cache: cord-328040-5qd05e4r.txt plain text: cord-328040-5qd05e4r.txt item: #2248 of 2876 id: cord-328068-qoz85x3r author: Alanio, Alexandre title: The presence of Pneumocystis jirovecii in critically ill patients with COVID-19 date: 2020-11-04 words: 1386 flesch: 41 summary: However, to the best of our knowledge, this is the first study evaluating the prevalence of P. jirovecii in COVID-19 patients. We found an unexpectedly high proportion of critically ill COVID-19 patients detected with P. jirovecii (10/108 patients; 9.3%), similarly to previous findings in influenza patients (3/45; ~7%). keywords: covid-19; jirovecii; patients cache: cord-328068-qoz85x3r.txt plain text: cord-328068-qoz85x3r.txt item: #2249 of 2876 id: cord-328113-eczjjc2v author: D’Alessandro, Angelo title: Serum Proteomics in COVID-19 Patients: Altered Coagulation and Complement Status as a Function of IL-6 Level date: 2020-07-30 words: 4675 flesch: 28 summary: Nonetheless, to date, no study has measured coagulation protein levels in COVID-19 patients. While the levels of pro-inflammatory cytokines such as interleukin-6 (IL-6) have been associated with the severity of the disease, little is known about the impact of IL-6 levels on the proteome of COVID-19 patients. keywords: complement; cov-2; covid-19; covid-19 patients; disease; figure; il-6; il-6 levels; levels; patients; protein; sars; sera; serum cache: cord-328113-eczjjc2v.txt plain text: cord-328113-eczjjc2v.txt item: #2250 of 2876 id: cord-328147-61gtx2h2 author: Lopez-Mendez, Ivan title: Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19) date: 2020-10-21 words: 2665 flesch: 44 summary: In COVID-19 patients, the prevalence of liver steatosis and advanced liver fibrosis by noninvasive assessment prediction models was high and was not associated with clinical outcomes; 96.8% of COVID-19 patients had at least one abnormal LFT. Liver function tests (LFT) abnormalities are reported in up to 50% of COVID-19 patients, metabolic comorbidities are associated with poorer outcomes. keywords: covid-19; fibrosis; liver; outcomes; patients; prevalence; study cache: cord-328147-61gtx2h2.txt plain text: cord-328147-61gtx2h2.txt item: #2251 of 2876 id: cord-328214-2azb8789 author: Piper-Vallillo, Andrew J. title: COVID-19 Infection in a Lung Cancer Patient Population: Incidence, Presentation and Alternative Diagnostic Considerations date: 2020-11-12 words: 4122 flesch: 37 summary: COVID-19 positive patients (n = 24) were predominantly current or former smokers (87%), white (84%) and older (median age 75 years , range 57-87) Findings from larger cohorts, such as the CCC19 consortium, have also indicated age and poor PS are risk factors for mortality/poor outcomes in COVID-19 positive oncology patients. keywords: cancer; covid-19; infection; lung; patients; population; testing; therapy cache: cord-328214-2azb8789.txt plain text: cord-328214-2azb8789.txt item: #2252 of 2876 id: cord-328220-toeq4xq0 author: Smith, Kelly title: Practical Considerations in Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID-19 date: 2020-07-06 words: 3213 flesch: 34 summary: Understanding of these abnormalities is continually evolving, but these conditions may pose a risk to COVID-19 patients beyond the risk typically seen in critically ill patients. 3, 4 Poissy et al 5 reported an increased incidence of pulmonary embolism (PE) amongst COVID-19 patients admitted to an intensive care unit. keywords: anticoagulation; covid-19; patients; prophylaxis; risk; therapy; tier; vte cache: cord-328220-toeq4xq0.txt plain text: cord-328220-toeq4xq0.txt item: #2253 of 2876 id: cord-328289-3h3kmjlz author: Iadecola, Costantino title: Effects of COVID-19 on the nervous system date: 2020-08-19 words: 6543 flesch: 28 summary: Furthermore, several autopsy series have revealed a notable lack of immune cell infiltration (Kantonen et al., 2020; Reichard et al., 2020; Solomon et al., 2020) . Consistent with hypoxic brain injury, autopsy studies in COVID-19 have shown neuronal damage in brain regions most vulnerable to hypoxia, including neocortex, hippocampus and cerebellum (Kantonen et al., 2020; Reichard et al., 2020; Solomon et al., 2020) . keywords: acute; brain; cells; covid-19; disease; encephalitis; entry; et al; evidence; human; infection; manifestations; patients; sars; system; virus cache: cord-328289-3h3kmjlz.txt plain text: cord-328289-3h3kmjlz.txt item: #2254 of 2876 id: cord-328294-gii1b7s7 author: Doty, Richard L. title: Olfaction and Its Alteration by Nasal Obstruction, Rhinitis, and Rhinosinusitis date: 2009-01-02 words: 10877 flesch: 33 summary: Within the field of otorhinolaryngology, they have revealed that 1) surgical and medical interventions in patients with rhinosinusitis do not, on average, lead to complete recovery of olfactory function, despite common beliefs to the contrary, and 2) associations are generally lacking between measures of airway patency and olfactory function in such cases. [17] [18] ; third, significant loss of olfactory function occurs after the age of 65 years, with more than half of persons between 65 and 80 years of age and more than three-quarters of those 80 years of age and older having such loss 16, 18, 19 ; fourth, women, on average, retain the ability to smell longer than men 16 ; fifth, the decreased smell ability associated with smoking is present in prior cigarette smokers, and recovery to presmoking levels, while possible, can take years, depending on the amount and duration of prior smoking 20 ; and sixth, olfactory function is compromised in urban residents and in workers in some industries, including the paper and chemical manufacturing industries. keywords: detection; disease; function; identification; loss; nasal; odor; olfactory; patients; rhinitis; scores; smell; studies; study; surgery; test; threshold; upsit cache: cord-328294-gii1b7s7.txt plain text: cord-328294-gii1b7s7.txt item: #2255 of 2876 id: cord-328307-378cfb23 author: Shirazi, Samira title: Sudden cardiac death in COVID-19 patients, a report of three cases date: 2020-07-03 words: 1985 flesch: 47 summary: Clinical features of patients infected with 2019 novel coronavirus in Wuhan • First report of COVID-19 in Lancet Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China • First report of COVID-19 in JAMA From SARS to MERS, thrusting coronaviruses into the spotlight Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study • First report of complete heart block from our institution New clinical experiences and evaluation of clinical and paraclinical features of deceased patients with COVID-19 infection referred to Shahid Mostafa Khomeini Hospital of Ilam • Introduces a hypothesis that cytokine storm may induce QT prolongation and torsades de pointes Association of cardiovascular manifestations with in-hospital outcomes in patients with COVID-19: a hospital staff data. key: cord-328307-378cfb23 authors: Shirazi, Samira; Mami, Sanaz; Mohtadi, Negar; Ghaysouri, Abas; Tavan, Hamed; Nazari, Ali; Kokhazadeh, Taleb; Mollazadeh, Reza title: Sudden cardiac death in COVID-19 patients, a report of three cases date: 2020-07-03 journal: keywords: covid-19; death; hospital; patients cache: cord-328307-378cfb23.txt plain text: cord-328307-378cfb23.txt item: #2256 of 2876 id: cord-328384-jzfr2t3p author: Mudatsir, Mudatsir title: Predictors of COVID-19 severity: a systematic review and meta-analysis date: 2020-09-09 words: 4577 flesch: 37 summary: Furthermore, pulmonary embolism and deep vein thrombosis were also observed in patients with severe COVID-19 73, 74 , which suggests that D-dimer might play a prominent role in governing the severity of COVID-19 patients. Publisher Full Text Pathological findings of COVID-19 associated with acute respiratory distress syndrome The Clinical Manifestations and Chest Computed Tomography Findings of Coronavirus Disease 2019 (COVID-19) Patients in China: A Proportion Meta-Analysis Laboratory findings of COVID-19: a systematic review and meta-analysis Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis PubMed Abstract | Publisher Full Text | Free Full Text COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network -United States Predictors of COVID-19 severity: a systematic review and meta-analysis. keywords: analysis; covid-19; data; disease; levels; meta; patients; review; risk; studies; study cache: cord-328384-jzfr2t3p.txt plain text: cord-328384-jzfr2t3p.txt item: #2257 of 2876 id: cord-328438-irjo0l4s author: Krittanawong, Chayakrit title: Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management date: 2020-10-09 words: 10205 flesch: 24 summary: Historically, medical device data have been kept in databases owned and maintained by industry and accessible by health-care providers, yet with more limited accessibility for patients. key: cord-328438-irjo0l4s authors: Krittanawong, Chayakrit; Rogers, Albert J.; Johnson, Kipp W.; Wang, Zhen; Turakhia, Mintu P.; Halperin, Jonathan L.; Narayan, Sanjiv M. title: Integration of novel monitoring devices with machine learning technology for scalable cardiovascular management date: 2020-10-09 journal: keywords: arrhythmias; cardiac; care; data; detection; devices; ecg; fibrillation; health; heart; learning; machine; management; monitoring; patients; rate; study; technology; use; wearable cache: cord-328438-irjo0l4s.txt plain text: cord-328438-irjo0l4s.txt item: #2258 of 2876 id: cord-328484-4iptwc3n author: Li, Tao title: Clinical Characteristics of 312 Hospitalized Older Patients with COVID-19 in Wuhan, China date: 2020-07-15 words: 3082 flesch: 46 summary: High levels of d-dimer had a reported association with pneumonia severity in emergency department, which also applied to older COVID-19 patients. But substantial numbers of severe episodes occur in older patients. keywords: cases; clinical; coronavirus; covid-19; patients; study cache: cord-328484-4iptwc3n.txt plain text: cord-328484-4iptwc3n.txt item: #2259 of 2876 id: cord-328487-glwslgjy author: Iannaccone, Sandro title: ROLE OF REHABILITATION DEPARTMENT FOR ADULT COVID-19 PATIENTS: THE EXPERIENCE OF THE SAN RAFFAELE HOSPITAL OF MILAN date: 2020-06-04 words: 1954 flesch: 31 summary: glwslgjy Abstract The rapid evolution of the health emergency linked to the spread of SARS-CoV-2 requires specifications for the rehabilitative management of COVID-19 patients. The symptomatic evolution of COVID-19 patients is characterized by two phases: an acute phase in which respiratory symptoms prevail, and a post-acute phase in which patients can show symptoms related to prolonged immobilization, to previous and current respiratory dysfunctions as well as cognitive and emotional disorders. keywords: care; covid-19; hospital; patients; rehabilitation cache: cord-328487-glwslgjy.txt plain text: cord-328487-glwslgjy.txt item: #2260 of 2876 id: cord-328513-81yvcgul author: Bellastella, Giuseppe title: Revisitation of autoimmune hypophysitis: knowledge and uncertainties on pathophysiological and clinical aspects date: 2016-08-08 words: 9664 flesch: 31 summary: Longitudinal behavior of autoimmune GH deficiency: from childhood to transition age Antipituitary antibodies in idiopathic hyperprolactinemic patients Effect of long-term cabergoline therapy on the immunological pattern and pituitary function of patients with idiopathic hyperprolactinaemia positive for antipituitary antibodies Long-term clinical course of IgG4-related systemic disease accompanied by hypophysitis IgG4-related disease Hypophysitis presented as inflammatory pseudotumor in immunoglobulin G4-related systemic disease IgG4 breaking the rules IgG4-related hypophysitis: a new addition to the hypophysitis spectrum A case of IgG4-related hypophysitis without pituitary insufficiency From Japan with love: another tessera in the hypophysitis mosaic Endocrine side-effects of anti-cancer drugs: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4 Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis Effect of cancer treatment on hypothalamic-pituitary function Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma Ipilimumab treatment associated pituitary hypophysitis: clinical presentation and imaging diagnosis Ipilimumab-induced autoimmune hypophysitis: a differential for sellar mass lesions Anticytotoxic T-lymphocyte antigen-4 induced autoimmune hypophysitis: a case report and literature review Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights Pituitary medicine from discovery to patientfocused outcomes Lymphocytic hypophysitis with lachrymal, salivary and thyroid gland involvement Lymphocytic hypophysitis with cystic MRI appearance Primary pituitary lymphoma presenting as hypophysitis Hypocortisolism in survivors of severe acute respiratory syndrome (SARS) They show massive pituitary infiltration by lymphocytes (T more than B lymphocytes, mainly of the CD4 class), plasma cells and macrophages, grouped in aggregates surrounding atrophic acini of pituitary cells [33] keywords: antibodies; apa; autoimmune; cases; cells; diagnosis; disease; hormone; hypophysitis; igg4; lyh; patients; pituitary; results cache: cord-328513-81yvcgul.txt plain text: cord-328513-81yvcgul.txt item: #2261 of 2876 id: cord-328525-80xk3gln author: Baier, Claas title: Influenza and respiratory syncytial virus screening for the detection of asymptomatically infected patients in hematology and oncology date: 2018-09-24 words: 3391 flesch: 35 summary: The 6 patients showed an increase in viral load during their clinical course and were therefore presumably detected during the incubation period. 13 of the 23 (57%) asymptomatic patients were in twoand four-bed rooms at the time the screening test was reported positive (4 positive for RSV, 9 positive for influenza virus). Competing interests Respiratory syncytial virus -a comprehensive review Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe Community acquired respiratory virus infections in cancer patients -Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology Respiratory viruses in transplant recipients: more than just a cold. keywords: control; infection; influenza; patients; rsv; screening; virus cache: cord-328525-80xk3gln.txt plain text: cord-328525-80xk3gln.txt item: #2262 of 2876 id: cord-328569-1lx3fkv3 author: Bagate, François title: Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndrome date: 2020-11-04 words: 3769 flesch: 44 summary: During the first SARS-CoV outbreak in 2004, a pilot study reported the efficacy of iNO in a limited series of severe patients, with reversal of pulmonary hypertension, improved hypoxemia and shortened duration of mechanical ventilation [20] . The NO Almitrine Study Group Inhaled nitric oxide and vasoconstrictors in acute respiratory distress syndrome Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome Acute respiratory distress syndrome: the Berlin Definition Formal guidelines: management of acute respiratory distress syndrome Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review Potential for lung recruitment estimated by the recruitment-toinflation ratio in acute respiratory distress syndrome a clinical trial Prevalence and prognosis of cor pulmonale during protective ventilation for acute respiratory distress syndrome Prevalence and prognosis of shunting across patent foramen ovale during acute respiratory distress syndrome The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. keywords: acute; almitrine; ards; covid-19; distress; ino; patients; pulmonary; study; syndrome cache: cord-328569-1lx3fkv3.txt plain text: cord-328569-1lx3fkv3.txt item: #2263 of 2876 id: cord-328607-lzai90zq author: Augoustides, John G. title: Cardiovascular Consequences and Considerations of Coronavirus Infection – Perspectives for the Cardiothoracic Anesthesiologist and Intensivist During the Coronavirus Crisis date: 2020-04-09 words: 2076 flesch: 29 summary: Cardiovascular and Thoracic Section, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Clinical characteristics of coronavirus disease 2019 in China Clinical features of patients with 2019 novel coronavirus in Wuhan, China Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study Outbreak of a new coronavirus: What anaesthetists should know Anesthetic management of patients undergoing aortic dissection repair with suspected severe acute respiratory syndrome coronavirus-2 infection Perioperative echocardiography: Key considerations during the coronavirus pandemic Protecting high-risk cardiac patients during the COVID-19 outbreak Extracorporeal membrane oxygenation À crucial considerations during the coronavirus crisis Guidance document: Extracorporeal membrane oxygenation for COVID-19 patients with severe cardiopulmonary failure Anesthetic management of patients with suspected or confirmed 2019 novel coronavirus infection during emergency procedure Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected -interim guidance Cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic COVID-19 infection À implications for perioperative and critical care physicians Evidence from a meta-analysis Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) Potential effects of coronaviruses on the cardiovascular system: A review Viral myocarditis À incidence, diagnosis and management Cardiovascular magnetic resonance in myocarditis: A JACC white paper Catheterization laboratory considerations during the coronavirus-19 (COVID-19) pandemic: From ACC's Interventional Council and SCAI CSC expert consensus on principles of clinical management of patients with severe emergent cardiovascular disease during the COVID-19 epidemic Coronavirus disease 2019 (COVID-19) and cardiovascular disease SARS Àcoronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS COVID-19 and the cardiovascular system Angiotensin II for the treatment of COVID-19-related vasodilatory shock Coronaviruses and the cardiovascular system: Acute and long-term implications SARS-CoV2: Should inhibitors of the renin-angiotensin system be withdrawn in patients with COVID-19? Inflammation and thrombosis: [1] [2] [3] [4] In the cohort of patients with severe COVID-19, the risks of admission to an intensive care unit are high owing to critical conditions such as acute respiratory distress syndrome, cardiovascular collapse, and acute renal failure. keywords: angiotensin; coronavirus; covid-19; management; myocarditis; patients cache: cord-328607-lzai90zq.txt plain text: cord-328607-lzai90zq.txt item: #2264 of 2876 id: cord-328640-4g7revha author: Douedi, Steven title: Novel coronavirus 2019 (COVID-19): A case report and review of treatments date: 2020-05-08 words: 2282 flesch: 44 summary: Further studies and clinical trials are required to fully understand the role of remdesivir and other medications in COVID-19 infected patients. A chest X-ray ( Fig. 1 ) was performed showing bilateral opacities throughout the lung fields with predominance of the lower lung lobes she was admitted for possible pneumonia with isolation precautions for suspected COVID-19 and was started on oxygen via nasal cannula and on 1-gram ceftazidime intravenously every 8 hours and 500 mg azithromycin orally daily. keywords: coronavirus; covid-19; day; hydroxychloroquine; patient; treatment cache: cord-328640-4g7revha.txt plain text: cord-328640-4g7revha.txt item: #2265 of 2876 id: cord-328786-gkd9xcxa author: Mohammad, Laila Malani title: Necessity of brain imaging in COVID-19 infected patients presenting with acute neurological deficits date: 2020-08-13 words: 1083 flesch: 35 summary: These cases highlight the importance of early head imaging in COVID-19 patients with a poor neurological exam. According to a recent review of the stroke hospitalizations in a major center in New York, while the overall reported rates of strokes in COVID-19 patients were low, this patient population presenting with CVAs tended be younger and more severe compared to non-COVID patients, as seen in our two cases. keywords: covid-19; exam; patients cache: cord-328786-gkd9xcxa.txt plain text: cord-328786-gkd9xcxa.txt item: #2266 of 2876 id: cord-328814-s3963anw author: XU, Jing title: Exploration on the feasibility of moxibustion in prevention and treatment of COVID-19 from the perspective of modern medical mechanism date: 2020-06-11 words: 3457 flesch: 40 summary: Feasibility of yiqi xuanbi decoction in treating pulmonary fibrosis after new crown pneumonia Effects of Moxibustion of Feishu (BL13) and Gaohuangshu (BL43) on expression of E-cad Gene in lung epithelial cells in BLMA5-induced pulmonary fibrosis rats Regulation of E-cad, α-SMA and vimentin through moxibustion at Feishu and Gaohuangshu of pulmonary fibrosis rats Combined with Qiangli Zhike Capsule (强力止咳宁胶囊) on Chronic Bronchitis Clinical observation of yang-supplementing fire moxibustion for chronic obstructive pulmonary disease in stable stage Contribution of physicians in the south of the Five Ridges in acupuncture and moxibustion treatment of plague and cholera Clinical observation of moxibustion in the treatment of 79 cases of epidemic hemorrhagic fever Observation on the effect of moxibustion on renal function of epidemic hemorrhagic fever 20 cases of condyloma acuminatum treated with moxibustion Retrospective analysis of Mr. Xie Xiliang's medical records accumulated in 30 years on direct moxibustion for treating hepatitis B Clinical observation of treating refractory pulmonary tuberculosis with garlic moxibustion A pneumonia outbreak associated with a new coronavirus of probable bat origin Nine cases of the chronic stage of SARS treated by moxibustion Clinical observation of heat-sensitive moxibustion treatment for coronavirus disease Discussion on the effect pathways of preventing and treating coronavirus disease 2019 by acupuncture and moxibustion from the regulation of immune inflammatory response On TCM diagnosis and treatment program of Coronavirus Disease 2019 in Hunan province by national TCM Master XIONG Jibo Discussion on traditional Chinese medicine prevention and treatment strategies of Coronavirus Disease 2019 (COVID-19) from the perspective of cold-dampness pestilence The role of immunological testing and intervention in reproductive medicine: A fertile collaboration? Analysis of novel coronavirus pneumonia related blood test indexes in 80 cases Clinical characteristics and laboratory results of 3 886 patients with fever and cough Therapeutic effect of ginger warming and moxibustion on children's cough variant asthma and its influence to on immune function Regulation effect of moxibustion with small moxa-cone about the size of a wheat grain at zusanli point on cellular immune function in elderly bedridden patients Clinical study on the effect of Du-moxibustion therapy on the symptom and levels of serum supplement C3 and C4 in yang-deficiency subjects The effect of moxibustion shenque point on immune function of digestive tract cancer patients undergoing chemotherapy Effect of moxibustion on survival status and nutritional metabolic factor in tumor-bearing rats with gastric cancer Effect of solar-term moxibustion on hemorheology and immune function in patients with subhealth status of yang deficiency Molecular pathways in virus-induced cytokine production Therapeutic strategies for COVID-19 based on its pathophysiological mechanisms Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Effect of electroacupuncture stimulation of Feishu (BL 13) on lung index, serum and lung IL-10 and and TNF-α levels in mice with viral pneumonia Effect of mild moxibustion on bacterial infection and inflammation in mice and related autophagy mechanism Effect of moxibustion on body weight and peripheral and cerebral cortical IL-6 and IL-10 levels in fatigue rats Mechanism study on NIK/NF-κB/VEGF pathway, anti-inflammation and analgesia in RA treated with moxibustion Effect of moxibustion on TGF-β1, HIF-1α and VEGF levels in patients with rheumatoid arthritis (RA) Effects of moxa-moxibustion plus infrared illumination on community acquired pneumonia and immune function Thinking of the effect of integrated Chinese and western medicine on COVID-19 Dynamic changes of serum SARS-coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge keywords: body; covid-19; disease; effect; function; moxibustion; patients; treatment; yang cache: cord-328814-s3963anw.txt plain text: cord-328814-s3963anw.txt item: #2267 of 2876 id: cord-328829-yywxmioq author: Boixeda, Ramon title: Microbiological study of patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the usefulness of analytical and clinical parameters in its identification (VIRAE study) date: 2012-05-25 words: 3828 flesch: 36 summary: This prospective observational study of patients admitted for AE-COPD (VIR-AE) included a 2-year follow-up period and was intended to identify the infectious etiology of COPD exacerbations (whether viral or bacterial), as well as to describe the clinical features and analytical variables used to differentiate the cause of exacerbation. A study of stable and exacerbated outpatients using the protected specimen brush Respiratory viral infections in adults with and without chronic obstructive pulmonary disease Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations Prevalence of viral infection detected by PCR and RT-PCR in patients with acute exacerbation of COPD: a systematic review Diagnosis and management of chronic obstructive pulmonary disease: joint guidelines of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) and the Latin Antibiotics in chronic obstructive pulmonary disease exacerbations. keywords: copd; disease; etiology; exacerbations; patients; sputum; study; techniques cache: cord-328829-yywxmioq.txt plain text: cord-328829-yywxmioq.txt item: #2268 of 2876 id: cord-328895-p75b7jii author: Kim, Yeon-Yong title: Effects of patients’ motives in choosing a provider on determining the type of medical institution date: 2017-11-22 words: 2726 flesch: 41 summary: Balancing Health Needs, Services, and Technology Assessment of primary care level in Korea and comparison with the developed countries MERS outbreak in Korea: hospital-to-hospital transmission Evidence of a broken healthcare delivery system in Korea: unnecessary hospital outpatient utilization among patients with a single chronic disease without complications The impact of outpatient coinsurance rate increase on outpatient healthcare service utilization in tertiary and general hospital The relationships among quality, value, satisfaction and behavioral intention in health care provider choice: a South Korean study A study for the factors on choosing hospitals and patients satisfaction between geriatric hospitals and general hospitals Do patients always prefer quicker treatment? 1,2 Starfield 3 evaluated the elements composing the primary health care system of a country and reported that the lower the level of primary health care, the more it affected health outcomes, health care expenditures, and patient satisfaction. keywords: care; factors; health; hospitals; patient; quality cache: cord-328895-p75b7jii.txt plain text: cord-328895-p75b7jii.txt item: #2269 of 2876 id: cord-329152-1ixylnny author: Gupta, Shaili title: Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System date: 2020-04-24 words: 3496 flesch: 44 summary: Portable forced air system was used to create such rooms in an ICU section too that was devoted to COVID-19 patient care. 4.2 ICU and on-ward policy of care was devised and revised in real-time to continue state-of-the-art management of COVID-19 patients, with a multidisciplinary team approach, involving General Medicine, Cardiology, Infectious Diseases, Infection Prevention, Pulmonary and Critical Care Medicine, and Pharmacy. keywords: care; clinical; covid-19; healthcare; hospital; pandemic; patients; response; rooms cache: cord-329152-1ixylnny.txt plain text: cord-329152-1ixylnny.txt item: #2270 of 2876 id: cord-329215-awxfetdj author: Carter, Chris title: COVID-19 Disease: invasive ventilation date: 2020-06-01 words: 5520 flesch: 40 summary: Mechanical ventilation in the critically ill patient: international nursing perspectives Emergency Intubation outside Operating Room/Intensive Care Unit Settings: Are We Following the Recommendations for Safe Practice? Clinical guide for the management of critical care patients during the coronavirus pandemic Consensus guidelines for managing the airway in patients with COVID-19 Device or target? The monitoring of ventilated patients must include ECG, pulse oximetry and End Tidal Carbon Dioxide (EtCO 2 ). keywords: airway; care; circuit; complications; covid-19; ett; intubation; oxygenation; patients; pressure; ventilation; weaning cache: cord-329215-awxfetdj.txt plain text: cord-329215-awxfetdj.txt item: #2271 of 2876 id: cord-329344-06uk5sjp author: Neumann-Podczaska, Agnieszka title: COVID 19 - Clinical Picture in the Elderly Population: A Qualitative Systematic Review date: 2020-07-23 words: 5928 flesch: 40 summary: Description: Ground Glass Opacities (GGO) was the most commonly reported observation in radiological imaging of older COVID-19 patients. 10-18, 24-26, 28 Besides a risk for secondary infection or ARDS, older COVID-19 patients are prone to renal injury over the course of the disease. keywords: clinical; covid-19; data; disease; findings; patients; population; review; studies; study cache: cord-329344-06uk5sjp.txt plain text: cord-329344-06uk5sjp.txt item: #2272 of 2876 id: cord-329351-g9qlo3xh author: Toraih, Eman A. title: Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID‐19 patients: A meta‐regression and Decision tree analysis date: 2020-06-12 words: 1907 flesch: 42 summary: In addition, meta-analysis showed that COVID-19 patients who developed complications were more likely to have adverse outcomes with higher risk of mortality ( Furthermore, as depicted in Table 2 patients who received antibiotics (OR = 3.36, 95%CI = 1.66 to 6.77, p = 0.001), glucocorticoids (OR = 3.52, 95%CI = 2.51 to 4.93, p <0.001), immunoglobulins (OR = 3.41, 95%CI = 1.90 to 6.14, p <0.001), and hydroxychloroquine (OR = 6.67, 95%CI = 2.0 to 22.2, p = 0.002) had higher risk for poor prognosis. Table S1 summarizes pooled estimates for seven cardiac biomarkers, eight comorbidities, and nine secondary complications in COVID-19 patients with severe presentation compared to non-severe cohorts, who developed secondary cardiac injury versus not, ICU admitted patients versus general ward patients and survived versus expired. keywords: analysis; covid-19; mortality; patients cache: cord-329351-g9qlo3xh.txt plain text: cord-329351-g9qlo3xh.txt item: #2273 of 2876 id: cord-329444-t8ixrdpq author: Persaud., Yudy K. title: Ten Rules for Implementation of a Telemedicine Program to Care for Patients with Asthma date: 2020-10-08 words: 2576 flesch: 47 summary: key: cord-329444-t8ixrdpq authors: Persaud., Yudy K.; Portnoy, Jay title: Ten Rules for Implementation of a Telemedicine Program to Care for Patients with Asthma date: 2020-10-08 journal: J Allergy Clin Immunol Pract DOI: 10.1016/j.jaip.2020.10.005 sha: doc_id: 329444 cord_uid: t8ixrdpq nan has been shown to be effective for treating patients with asthma, only 6% of allergy practices used TM, 67 making allergy/immunology the specialty with the lowest adoption rate of any of the surveyed 68 specialties. You can use the free version and send the link via a 398 free text platform (. i.e. textfree.us) Patient does not need to download an App Telemedicine Association Home telemonitoring and remote feedback between clinic visits for asthma Telehealth delivery of adherence 518 and medication management system improves outcomes in inner-city children with asthma Telemedicine is as effective as in-person visits for patients 521 with asthma Do Patients of Subspecialist 523 Physicians Benefit from Written Asthma Action Plans? Real-world evaluation of a mobile 525 health application in children with asthma Written individualised management plans for asthma in children and adults The uses of telemedicine to improve asthma control keywords: asthma; health; patient; telemedicine; use; visit cache: cord-329444-t8ixrdpq.txt plain text: cord-329444-t8ixrdpq.txt item: #2274 of 2876 id: cord-329453-ry1diso2 author: Hammer, Mark M. title: Radiologist Reporting and Operational Management for Patients with Suspected COVID-19 date: 2020-06-11 words: 2507 flesch: 30 summary: Primary outcome was percentage of COVID-19 reports using recommended terminology; secondary outcome was percentages of suspected and unsuspected patients diagnosed with COVID-19. Results Among 77,400 total reports, 1,083 suggested COVID-19 based on imaging findings; 774 (71%) of COVID-19 reports used recommended terminology. keywords: covid-19; findings; imaging; patients; reports cache: cord-329453-ry1diso2.txt plain text: cord-329453-ry1diso2.txt item: #2275 of 2876 id: cord-329564-tmi1u224 author: Arashiro, Takeshi title: COVID-19 in 2 Persons with Mild Upper Respiratory Tract Symptoms on a Cruise Ship, Japan date: 2020-06-17 words: 1998 flesch: 52 summary: Coronavirus disease (COVID-19) outbreak Regarding COVID-19 cases on a cruise ship Cabinet order to designate novel coronavirus infection 2019 as designated infectious disease Clinical features of patients infected with 2019 novel coronavirus in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China A novel coronavirus emerging in China-key questions for impact assessment Emergency ministerial meeting on COVID-19 organized by the African Union and the Africa Centres for Disease Control and Prevention Discharge criteria for COVID-19 patients SARS-CoV-2 viral load in upper respiratory specimens of infected patients The work was supported by Major Project of Wenzhou Municipal Science and Technology Bureau (ZY202004). Other case-patients who had been on other floors denied any direct contact with confirmed patients from floor 7, but they shared common building facilities (e.g., restrooms, elevators). keywords: case; day; patients; ship; symptoms cache: cord-329564-tmi1u224.txt plain text: cord-329564-tmi1u224.txt item: #2276 of 2876 id: cord-329582-y4gyw8vz author: Tham, Hui-Yu title: Is There Still a Role for Physical Consultation in Colorectal Cancer Surveillance? date: 2020-08-31 words: 846 flesch: 39 summary: 5 Studies comparing CRC surveillance outcomes between GPs and specialists showed comparable outcomes in quality of life, disease recurrence rates, and time to detection of recurrence. Regardless, much work is required before any overhaul of CRC surveillance. keywords: cancer; patients; surveillance cache: cord-329582-y4gyw8vz.txt plain text: cord-329582-y4gyw8vz.txt item: #2277 of 2876 id: cord-329727-h47q76y8 author: Sisó-Almirall, Antoni title: Prognostic factors in Spanish COVID-19 patients: A case series from Barcelona date: 2020-08-21 words: 3445 flesch: 48 summary: This study summarizes the clinical, biological and radiological characteristics, evolution and prognostic factors of patients with COVID-19 disease in primary and community healthcare. A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Clinical Characteristics of Covid-19 in New York City Utility of hyposmia and hypogeusia for the diagnosis of COVID-19 COVID-19)-United States The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia keywords: 95%ci; admission; covid-19; death; icu; patients cache: cord-329727-h47q76y8.txt plain text: cord-329727-h47q76y8.txt item: #2278 of 2876 id: cord-329741-604gtqx9 author: Tombetti, Enrico title: Novel Pharmacotherapies for Recurrent Pericarditis: Current Options in 2020 date: 2020-06-19 words: 5751 flesch: 33 summary: Autoimmunity is suggested by the occurrence of RP in many systemic autoimmune diseases and by the detection of high titers of AHA and AIDA in up to 67.5% of IRP patients [5•] . Available IL-1 antagonists include anakinra and canakinumab [1••] , while rilonacept is a third molecule currently being studied on IRP patients by a phase 2 trial. keywords: agents; anakinra; anti; colchicine; disease; il-1; irp; patients; pericarditis; recurrent; therapy; treatment cache: cord-329741-604gtqx9.txt plain text: cord-329741-604gtqx9.txt item: #2279 of 2876 id: cord-329766-9bwdb6o2 author: Liu, Xiaofan title: Temporal radiographic changes in COVID-19 patients: relationship to disease severity and viral clearance date: 2020-06-24 words: 3194 flesch: 44 summary: The median viral clearance day for pneumonia patients was 21, ranging from 6 to 43; while in severe pneumonia patients, it was 20, ranging from 7.5 to 40.5 (Fig. 4B, p > 0.05) . The median values of days when the peak HRCT scores were reached in pneumonia or severe pneumonia patients were 12 vs. 14, respectively (p = 0.048). keywords: clearance; covid-19; disease; hrct; patients; pneumonia cache: cord-329766-9bwdb6o2.txt plain text: cord-329766-9bwdb6o2.txt item: #2280 of 2876 id: cord-329856-0m5mc320 author: Ahmad, Shandar title: Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date: 2020-06-04 words: 3765 flesch: 50 summary: However, the way in which a given viral variant might actually impact different patient age groups has not been well investigated. However, severity of infection, fatality rates, and treatment responses across different countries, age groups, and demographic groups suggest that the nature of infection is diverse, and a timely investigation of the same is needed for evolving sound treatment and preventive strategies. keywords: age; covid-19; data; groups; infection; patient; population cache: cord-329856-0m5mc320.txt plain text: cord-329856-0m5mc320.txt item: #2281 of 2876 id: cord-329863-r2vqsg5r author: Salamanna, Francesca title: Overt and non-overt disseminated intravascular coagulation and the potential role of heparin in the COVID-19 pandemic outbreak date: 2020-10-16 words: 2772 flesch: 33 summary: Clinical characteristics of coronavirus disease 2019 in China Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study Non-overt coagulopathy in non-ICU patients with mild to moderate COVID-19 pneumonia Evaluation of the diagnostic performance of fibrin monomer in comparison to d-dimer in patients with overt and nonovert disseminated intravascular coagulation Chapter 146 -Excessive Bleeding and Bruising Cutaneous manifestations in COVID-19: a first perspective COVID-19 can present with a rash and be mistaken for Dengue Hypothesis for potential pathogenesis of SARS-CoV-2 infection -a review of immune changes in patients with viral pneumonia Clinical observation and management of COVID-19 patients Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Heparin therapy improving hypoxia in COVID-19 patients -a case series The potential of low molecular weight heparin to mitigate cytokine storm in severe COVID-19 patients: a retrospective clinical study. [15] [16] Several data showed that patients with severe COVID-19 who did not survive may meet the criteria for overt DIC, evidencing that this form of DIC is a strong predictor of mortality in patients developing pneumonia. keywords: coagulation; coronavirus; covid-19; dic; heparin; overt; patients cache: cord-329863-r2vqsg5r.txt plain text: cord-329863-r2vqsg5r.txt item: #2282 of 2876 id: cord-329877-vish6v8e author: Lapinsky, Stephen E. title: ICU management of severe acute respiratory syndrome date: 2003-05-09 words: 2641 flesch: 42 summary: This means timing blood analysis and administration of any therapies to minimize entries and use of video camera equipment or windows to monitor SARS patients without direct staff exposure. SARS patients should never be transported while being supported by bag-valve-mask ventilation, and should preferably be intubated. keywords: disease; patients; risk; sars; staff; syndrome; therapy cache: cord-329877-vish6v8e.txt plain text: cord-329877-vish6v8e.txt item: #2283 of 2876 id: cord-329985-5rji08p7 author: Robba, Chiara title: Distinct phenotypes require distinct respiratory management strategies in severe COVID-19 date: 2020-05-11 words: 4384 flesch: 35 summary: The experience in COVID-19 patients from Wuhan was similar, with a high rate of noninvasive support failure and need for intubation and mechanical ventilation in 76% of cases; nevertheless, there was no difference in mortality between patients receiving noninvasive vs invasive ventilation . Continuous infusion of neuromuscular blocking agents (NMBA) should be reserved for COVID-19 patients in which intermittent dosing may not suffice, such as: patients undergoing prone positioning, persistent ventilator asynchrony, and those with high plateau pressures (Alhazzani et al., 2013) . keywords: chest; covid-19; failure; patients; ventilation cache: cord-329985-5rji08p7.txt plain text: cord-329985-5rji08p7.txt item: #2284 of 2876 id: cord-329989-176cvimy author: Federico, Antonio title: Scientific publishing in the COVID-19 era: successes and pitfalls date: 2020-07-02 words: 1746 flesch: 36 summary: These data, though limited, indicate that brainstem involvement may play a role in respiratory failure and perhaps in the high death rate of COVID-19 patients. Moreover, the weaning failure from mechanical ventilation due to central respiratory drive depression may underlie the unusually long stay in the ICU reported for COVID-19 patients. keywords: authors; covid-19; data; pandemic; patients cache: cord-329989-176cvimy.txt plain text: cord-329989-176cvimy.txt item: #2285 of 2876 id: cord-330050-05nnihst author: Li, Yang title: Emergency trauma care during the outbreak of corona virus disease 2019 (COVID-19) in China date: 2020-05-15 words: 4386 flesch: 42 summary: To regulate the emergency treatment of trauma patients during the outbreak, we drafted this paper from a trauma surgeon perspective according to practical experience in Wuhan. The article illustrates the general principles for the triage and evaluation of trauma patients during the outbreak of COVID-19, indications for emergency surgery, and infection prevention and control for medical personnel, providing a practical algorithm for trauma care providers during the outbreak period. keywords: care; china; coronavirus; covid-19; infection; novel; operation; outbreak; patients; personnel; trauma cache: cord-330050-05nnihst.txt plain text: cord-330050-05nnihst.txt item: #2286 of 2876 id: cord-330061-q4xi260z author: Ferreira, João Guimarães title: Pneumothorax as a late complication of COVID-19 date: 2020-08-31 words: 2424 flesch: 41 summary: Coronavirus disease (COVID-19): situation report -200 Deep impact of COVID-19 in the healthcare of Latin America: the case of Brazil Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Severe Covid-19 Frequency and distribution of chest radiographic findings in COVID-19 positive patients Sensitivity of chest CT for COVID-19: comparison to RT-PCR Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection Laboratory abnormalities in patients with COVID-2019 infection Dexamethasone in hospitalized patients with Covid-19: preliminary report Therapeutic strategies for critically ill patients with COVID-19 SARS-CoV-2 infection associated with spontaneous pneumothorax Diseases of the diaphragm, chest wall, pleura and mediastinum Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Analysis of 92 deceased patients with Covid-19 Coronavirus disease 2019 (COVID-19): a systematic review of imaging findings in 919 patients Spontaneous pneumothorax and subcutaneous emphysema in COVID-19 patient: case report Pathological findings of COVID-19 associated with acute respiratory distress syndrome Whereas some patients with COVID-19 developed pneumothorax in association with risk factors, such as mechanical ventilation, in others the only factor was the viral pneumonia itself 19 . keywords: cases; chest; covid-19; day; disease; patients; pneumothorax cache: cord-330061-q4xi260z.txt plain text: cord-330061-q4xi260z.txt item: #2287 of 2876 id: cord-330136-o8df8szx author: Fan, Hua title: Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored date: 2020-05-11 words: 2170 flesch: 49 summary: Therefore, it is of great clinical significance to explore the clinical features and factors influencing prognosis of COVID-19 patients. This study enrolled COVID-19 patients, including 47 non-survivors and 26 survivors, admitted to the ICU. keywords: covid-19; patients; survivors; tni cache: cord-330136-o8df8szx.txt plain text: cord-330136-o8df8szx.txt item: #2288 of 2876 id: cord-330359-c0l5xq5m author: Curran, J title: Reducing potential aerosol generation in flexible nasolaryngoscopy: a novel method date: 2020-07-09 words: 1374 flesch: 55 summary: A device was developed that patients can wear to reduce potential aerosol contamination of the surroundings. In the context of an upper airway procedure requiring suction, use of a telemonitor and camera is recommended, instead of the eyepiece on the endoscope, to increase the distance between the operator and patient, and minimise aerosol inhalation. keywords: device; mask; patient; use cache: cord-330359-c0l5xq5m.txt plain text: cord-330359-c0l5xq5m.txt item: #2289 of 2876 id: cord-330368-rk31cwl4 author: Bowden, Kasey title: Harnessing the Power of Hospitalists in Operational Disaster Planning: COVID-19 date: 2020-07-13 words: 2463 flesch: 40 summary: The last guiding principle was conscientiousness of resources (people, systems, and cost), knowing that any plan needed sustainability, particularly since successfully flattening the curve would mean prolonging the plateau and thus prolongation of the surge of COVID-19 patients over time. To increase capacity while limiting the number of providers in the hospital, strategies were developed for remote patient care from home. keywords: care; covid-19; hospital; medicine; patients; providers; teams cache: cord-330368-rk31cwl4.txt plain text: cord-330368-rk31cwl4.txt item: #2290 of 2876 id: cord-330369-75cotmn2 author: López, Verónica title: Recommendations on management of the SARS-CoV-2 coronavirus pandemic (Covid-19) in kidney transplant patients date: 2020-04-06 words: 3483 flesch: 42 summary: The Spanish Nephrology Society (www.senefro.org) and the Spanish Transplant Society (www.setrasplante.org) are conveying the recommendations of measures for prevention and contingency against COVID-19 in kidney patients, including kidney transplant patients. Most of the transplant centers in Spain already have cases of kidney transplant patients affected by COVID-19 that have not been published. keywords: coronavirus; covid-19; dose; infection; kidney; patients; population; transplant cache: cord-330369-75cotmn2.txt plain text: cord-330369-75cotmn2.txt item: #2291 of 2876 id: cord-330431-9txstz4n author: Nomikos, Iakovos N title: What Else but Covid-19 Pandemic? Lessons Learned date: 2020-07-11 words: 2564 flesch: 40 summary: As knowledge develops about the risks for cancer patients during the pandemic, major considerations for management include that both the cancer condition itself and its treatment may increase risk of serious COVID-19 complications. For this reason, many publications suggested recommendations for the prioritisation, treatment, and triage of cancer patients during the COVID-19 pandemic [13] . keywords: cancer; care; covid-19; health; pandemic; patients; treatment cache: cord-330431-9txstz4n.txt plain text: cord-330431-9txstz4n.txt item: #2292 of 2876 id: cord-330492-kbob8z48 author: Vervoort, Dominique title: Assessing the Collateral Damage of the Novel Coronavirus: A Call to Action for the Post-COVID-19 Era date: 2020-04-30 words: 1559 flesch: 34 summary: These include ensuring that a separate emergency team remains active and able to accept cases, minimizing crossover infections among patients and health workers, dedicating select hospitals, catheterization labs, operating rooms, and wards to non-COVID-19 patients, and allowing other healthcare personnel to become available when COVID-19 patients surge. Furthermore, it may include the need to have dedicated hospitals caring for COVID-19 patients only, whilst other hospitals outside heavily-hit areas take care of non-COVID-19 patients. keywords: care; covid-19; health; patients; time cache: cord-330492-kbob8z48.txt plain text: cord-330492-kbob8z48.txt item: #2293 of 2876 id: cord-330573-rr2r8245 author: Stockmann, Helena title: CytoResc – “CytoSorb” Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trial date: 2020-06-26 words: 1703 flesch: 48 summary: Approximately 8 - 10 % of COVID-19 patients present with a serious clinical course and need for hospitalization, 8% of hospitalized patients need ICU-treatment. However, in a number of patients a severe hyperinflammatory response with excessively elevated proinflammatory cytokines causes vasoplegic shock resistant to vasopressor therapy. keywords: cytosorb; patients; protocol; study; trial cache: cord-330573-rr2r8245.txt plain text: cord-330573-rr2r8245.txt item: #2294 of 2876 id: cord-330597-nftwj0d5 author: Hopfer, Helmut title: Hunting coronavirus by transmission electron microscopy – a guide to SARS‐CoV‐2‐associated ultrastructural pathology in COVID‐19 tissues date: 2020-09-27 words: 4639 flesch: 41 summary: All rights reserved SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States Culture-Based Virus Isolation To Evaluate Potential Infectivity of Clinical Specimens Tested for COVID-19 Detection and Isolation of SARS-CoV-2 in Serum, Urine, and Stool Specimens of COVID-19 Patients from the Republic of Korea Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms Molecular Biology Coronaviruses post-SARS: update on replication and pathogenesis An Overview of Their Replication and Pathogenesis A Novel Coronavirus from Patients with Pneumonia in China Proliferative growth of SARS coronavirus in How COVID-19 spreads Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 Reducing transmission of SARS-CoV-2 Community-Acquired Respiratory Viruses in Transplant Patients: Diversity, Impact, Unmet Clinical Needs SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes Accepted Article keywords: article; copyright; coronavirus; covid-19; electron; infection; membrane; patients; replication; sars cache: cord-330597-nftwj0d5.txt plain text: cord-330597-nftwj0d5.txt item: #2295 of 2876 id: cord-330655-crfj5adf author: Haider, Asim title: COVID-19 and the Brain: Acute Encephalitis as a Clinical Manifestation date: 2020-10-03 words: 1607 flesch: 39 summary: Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients Possible central nervous system infection by SARS coronavirus Nervous system involvement after infection with COVID-19 and other coronaviruses First case of 2019 novel coronavirus disease with encephalitis Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms COVID-19: consider cytokine storm syndromes and immunosuppression How to carry out and interpret EEG recordings in COVID-19 patients in ICU? Brain MRI findings in patients in the intensive care unit with COVID-19 infection Neurologic features in severe SARS-CoV-2 infection Brain MRI findings in severe COVID-19: a retrospective observational study SARS-CoV-2-associated acute hemorrhagic, necrotizing encephalitis (AHNE) presenting with cognitive impairment in a 44-year-old woman without comorbidities: a case report Patients with severe symptoms are more likely to develop neurological symptoms than patients with mild or moderate disease [3] . keywords: acute; covid-19; disease; encephalitis; patients cache: cord-330655-crfj5adf.txt plain text: cord-330655-crfj5adf.txt item: #2296 of 2876 id: cord-330666-puhijixa author: Carrico, Ruth M. title: Changing health care worker behavior in relation to respiratory disease transmission with a novel training approach that uses biosimulation date: 2007-02-02 words: 3397 flesch: 42 summary: We used pre-/posttest knowledge assessments and observations of HCW-patient interactions to evaluate the impact of the visual demonstration of respiratory disease transmission on PPE use by HCWs. If the patient-subject interaction was appropriate, the observers evaluated the subject's behavior with regard to PPE use. keywords: care; group; patient; ppe; respiratory; study; training; use cache: cord-330666-puhijixa.txt plain text: cord-330666-puhijixa.txt item: #2297 of 2876 id: cord-330676-urr9oqfc author: Keny, Dr Swapnil title: Emergency and Urgent Orthopaedic Surgeries in non covid patients during the COVID 19 pandemic: Perspective from India date: 2020-05-12 words: 2212 flesch: 44 summary: Surgical patients may be classified into three risk categories for COVID-19: confirmed and suspected patients, high-risk patients, and low-risk patients (11) . Aligning the interests of clinicians, patients, hospital and government policy makers can be especially difficult (1, 2) . keywords: covid; covid-19; emergency; patients; surgeries; surgery cache: cord-330676-urr9oqfc.txt plain text: cord-330676-urr9oqfc.txt item: #2298 of 2876 id: cord-330701-k68b0wqe author: Gerc, Vjekoslav title: Cardiovascular Diseases (CVDs) in COVID-19 Pandemic Era date: 2020-06-17 words: 5524 flesch: 45 summary: Patients with CVDs must be observed by health professionals (specialists of cardiology, family practitioners, epidemiologists, etc) with special preventive measures regarding COVID-19 infection (1). A Review Effective treatment of severe COVID-19 patients with tocilizumab TH17 responses in cytokine storm of CO-VID-19: an emerging target of JAK2 inhibitor fedratinib COVID-19: consider cytokine storm syndromes and immunosuppression Flooded by the torrent: the COVID-19 drug pipeline Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic Sleep and Motion Disorders of Physicians and Nurses Working in Hospitals Facing the Pandemic of COVID-19 Pharmacologist's view of the new corona virus keywords: cells; covid-19; disease; heart; hypertension; infection; patients; sars; storm; system; virus cache: cord-330701-k68b0wqe.txt plain text: cord-330701-k68b0wqe.txt item: #2299 of 2876 id: cord-330831-3b7vfv9b author: Hao, Fengyi title: A quantitative and qualitative study on the neuropsychiatric sequelae of acutely ill COVID-19 inpatients in isolation facilities date: 2020-10-19 words: 8243 flesch: 41 summary: A greater proportion of COVID-19 patients experienced impulsivity (p = 0.016) and insomnia (p = 0.039) than psychiatric patients and healthy controls. COVID-19 patients reported a higher psychological impact of the outbreak than psychiatric patients and healthy controls, with half of them having clinically significant symptoms of posttraumatic stress disorder. keywords: anxiety; covid-19; covid-19 patients; depression; health; impact; infection; isolation; outbreak; pandemic; patients; stress; study; symptoms cache: cord-330831-3b7vfv9b.txt plain text: cord-330831-3b7vfv9b.txt item: #2300 of 2876 id: cord-330856-j1wqrc8v author: Matoori, Simon title: Addressing intimate partner violence during the COVID-19 pandemic and beyond: how radiologists can make a difference date: 2020-10-06 words: 3071 flesch: 37 summary: The most common anatomic locations of fractures in IPV patients. The aim of this Special Report is to raise awareness of IPV among radiologists and to suggest strategies by which to identify and support IPV victims. keywords: care; health; ipv; partner; patient; radiologists; victims; violence cache: cord-330856-j1wqrc8v.txt plain text: cord-330856-j1wqrc8v.txt item: #2301 of 2876 id: cord-330869-k5ro0edf author: Kumar Singh, Awadhesh title: Assessment of risk, severity, mortality, glycemic control and antidiabetic agents in patients with diabetes and COVID-19: A Narrative Review date: 2020-06-11 words: 5036 flesch: 38 summary: A Nationwide Analysis of China Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Clinical features and treatment of COVID-19 patients in northeast Chongqing Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Clinical Features of 69 Cases with Coronavirus Disease Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Clinical Characteristics of Coronavirus Disease 2019 in China Epidemiology Working Group for Ncip Epidemic Response. The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 26 2019 -United States Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol Hospitalization and 30-day fatality in 121,263 COVID-19 outpatient cases Predicting mortality due to SARS-CoV-2: A mechanistic score relating obesity and diabetes to COVID-19 outcomes in Mexico Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia -A systematic review, meta-analysis, and meta-regression Diabetes is a risk factor for the progression and prognosis of COVID-19 Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes Clinical course and risk factors or mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese center for disease control and prevention Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States OpenSAFELY: factors associated with COVID-19-related hospital death in the linked electronic health records of 17 million adult NHS patients Clinical considerations for patients with diabetes in times of COVID-19 epidemic Practical recommendation Lancet Diabetes & Endocrinology Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations Guidelines for the management of diabetes in care homes during the Covid-19 pandemic COVID-19 and endocrine diseases Our Response to COVID-19 as Endocrinologists and Diabetologists Should anti-diabetic medications be reconsidered amid COVID-19 pandemic? keywords: coronavirus; covid-19; diabetes; disease; increase; meta; mortality; patients; prevalence; risk; studies cache: cord-330869-k5ro0edf.txt plain text: cord-330869-k5ro0edf.txt item: #2302 of 2876 id: cord-330870-l0ryikhv author: Eubanks, Allison title: Obstetric Simulation for a Pandemic date: 2020-07-23 words: 3233 flesch: 41 summary: In the current COVID-19 pandemic, simulating obstetrical patient care from presentation to the hospital triage through postpartum care can prepare teams for even the most complicated patients while increasing their ability to protect themselves and their patients. Conclusion: In the current COVID-19 pandemic, simulating obstetrical patient care from presentation to the hospital triage through postpartum care can prepare teams for even the most complicated patients while increasing their ability to protect themselves and their patients. keywords: care; covid-19; pandemic; patients; room; simulation; teams cache: cord-330870-l0ryikhv.txt plain text: cord-330870-l0ryikhv.txt item: #2303 of 2876 id: cord-330877-nsx4b4rm author: Elcioglu, Omer Celal title: COVİD-19 infection in a membranous nephropathy patient treated with rituximab date: 2020-09-04 words: 2094 flesch: 49 summary: However, clinical studies have shown that ACEi or ARBs do not increase morbidity or mortality in COVID-19 patients [18] [19] [20] . In this period, one of our group of patients who are challenging us for follow-up and treatment are those who should start or continue to use immunosuppressive therapy. keywords: covid-19; immunosuppressive; kidney; march; patients; treatment cache: cord-330877-nsx4b4rm.txt plain text: cord-330877-nsx4b4rm.txt item: #2304 of 2876 id: cord-330918-hsy8h1vb author: Song, Jia title: A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19 date: 2020-07-28 words: 2942 flesch: 45 summary: Epidemiological, demographic, clinical, and laboratory data, as well as treatments, complications, and outcomes were extracted from electronic medical records and compared between elderly patients (aged ≥60 years) and younger patients (aged <60 years). Elderly patients had more complications than younger patients, including acute respiratory distress syndrome (ARDS; 9/25, 36% vs. 5/44, 11.4%) and cardiac injury (7/25, 28% vs. 1/44, 2.3%), and they were more likely to be admitted to the intensive care unit (6/25, 24% vs. 2/44, 4.5%). keywords: china; clinical; coronavirus; covid-19; patients; study cache: cord-330918-hsy8h1vb.txt plain text: cord-330918-hsy8h1vb.txt item: #2305 of 2876 id: cord-330963-w24q8sn7 author: Langston, Amelia A. title: Allocating Scarce Healthcare Resources during Pandemics: Making the Case for Patients with Advanced and Metastatic Cancer date: 2020-08-03 words: 1645 flesch: 30 summary: key: cord-330963-w24q8sn7 authors: Langston, Amelia A.; Quest, Tammie E.; Abernethy, Eli Rowe; Campbell, Gavin Paul; Owonikoko, Taofeek K.; Pentz, Rebecca D. title: Allocating Scarce Healthcare Resources during Pandemics: Making the Case for Patients with Advanced and Metastatic Cancer date: 2020-08-03 journal: Oncologist DOI: 10.1634/theoncologist.2020-0442 sha: doc_id: 330963 cord_uid: w24q8sn7 The oncology community is concerned that cancer patients will be unfairly classified in pandemic allocation guidances. In preparing for such scenarios, we propose several measures to assist with fair allocation of resources to cancer patients. keywords: cancer; patients; resources; survival cache: cord-330963-w24q8sn7.txt plain text: cord-330963-w24q8sn7.txt item: #2306 of 2876 id: cord-331109-a8e7r80d author: Ibrahim, Yassmin S. title: Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19 date: 2020-08-31 words: 2365 flesch: 42 summary: Moreover, Bhayana et al. 20 reported bowel wall abnormalities in 31% of abdominal CT scan images in COVID-19 patients, including pneumatosis and portal venous gas. Therefore, this could be a potential mechanism of paralytic ileus in severe COVID-19 cases. keywords: bowel; cases; covid-19; ileus; infection; patients; sars cache: cord-331109-a8e7r80d.txt plain text: cord-331109-a8e7r80d.txt item: #2307 of 2876 id: cord-331114-lumfg138 author: Berkman, Samuel A title: Methodological Issues and Controversies in COVID-19 Coagulopathy: A Tale of Two Storms date: 2020-09-03 words: 6284 flesch: 38 summary: This strategy is reinforced by the low incidence of bleeding observed in COVID patients compared with other causes of DIC such as obstetrical ones. While the major bleeding in trials involving COVID patients thus far appears to be low, full-dose anti-coagulation in such ill patients is not benign. keywords: anti; coagulation; covid; covid-19; cytokine; dose; hydroxychloroquine; patients; storm; thrombosis; trial; venous cache: cord-331114-lumfg138.txt plain text: cord-331114-lumfg138.txt item: #2308 of 2876 id: cord-331165-2yn1n3eq author: Tauben, David J. title: Optimizing telehealth pain care after COVID-19 date: 2020-08-20 words: 5918 flesch: 23 summary: management A crisis in chronic pain care: an ethical analysis. The effectiveness of exercise-based telemedicine on pain, physical activity and quality of life in the treatment of chronic pain: a systematic review Improving pain care with Project ECHO in community health centers Cognitive-behavioral-based physical therapy for patients with chronic pain undergoing lumbar spine surgery: a randomized controlled trial Australian Government Department of Health. keywords: access; care; covid-19; management; pain; pain management; patient; person; providers; review; services; systematic; telehealth; treatment cache: cord-331165-2yn1n3eq.txt plain text: cord-331165-2yn1n3eq.txt item: #2309 of 2876 id: cord-331268-kzy33hdb author: Lynch, Sharon G. title: Multiple sclerosis date: 1996-01-31 words: 13858 flesch: 43 summary: Multiple sclerosis and human Tcell lymphotrophic retroviruses Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients HTLV1 and tropical spastic paraparesis The G and Brahic M analysis of human Tlymphotrophic virus sequences in multiple sclerosis tissue Serologic studies of MS patients, controls, and patients with other neurologic diseases: antibodies to HTLV I Human T lymphotrophic virus type I may not be associated with multiple sclerosis in Japan Detection of human T-cell lymphoma virus type I DNA and antigen in spinal fluid and blood of patients with chronic progressive myelopathy Detection of coronavirus RNA and antigen in multiple sclerosis brain Bacterial toxin superantigens activate human T lymphocytes reactive with myelin autoantigens V-Beta specific stimulation of human T cells by staphylococcal toxins Findings in multiple sclerosis Problems of experimental trials of therapy in multiple sclerosis: report by the panel on evaluation of experimental trials of therapy in multiple sclerosis Influenza1 encephalopathy and post-influenza1 encephalitis Lyme disease: recommendations for diagnosis and treatment Human T-lymphocyte virus type I antibodies in the serum of patients with tropical spastic paraparesis in the Seychelles The diagnosis of childhood neurodegenerative disorders presenting as dementia in adults Textbook of child neurology Risk of developing multiple sclerosis after uncomplicated optic neuritis: a long-term prospective study Transverse myelitis: retrospective analysis of 33 cases, with differentiation of cases associated with multiple sclerosis and parainfectious events Long-term follow-up of acute partial transverse myelopathy Early risk of multiple sclerosis following isolated acute syndromes of the brainstem and spinal cord Prognostic significance of brain MRI at presentation with a clinically isolated syndrome suggestive of MS: a five-year follow-up study neuromyelitis optica and Schilder's myelinoclastic diffuse sclerosis Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up Multiple sclerosis: early prognostic guidelines Studies on the natural history of multiple sclerosis: eight early prognostic features of the later course of the illness Cardiovascular testing and exercise prescription in multiple sclerosis patients Multiple sclerosis. keywords: abnormalities; cell; chronic; diagnosis; disease; findings; lesions; mri; myelin; neuritis; optic; pain; patients; problems; progressive; sclerosis; spasticity; study; symptoms; therapy; treatment; use cache: cord-331268-kzy33hdb.txt plain text: cord-331268-kzy33hdb.txt item: #2310 of 2876 id: cord-331270-12zx0o2p author: Rico, Timóteo Matthies title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date: 2020-09-30 words: 5889 flesch: 46 summary: Results showed intervention group patients experienced fewer side effects compared to the control group in cycle 1 (p < 0.05), in general. The degree of satisfaction that cancer patients express about the information they receive has been associated with positive health outcomes, specifically regarding quality of life, performance status, side effects, and psychological well-being [18] . keywords: cancer; chemotherapy; cycle; effects; group; intervention; messages; patients; text; treatment cache: cord-331270-12zx0o2p.txt plain text: cord-331270-12zx0o2p.txt item: #2311 of 2876 id: cord-331273-1fixwxuo author: Abejón González, David title: How to restart the interventional activity in the COVID‐19 era. The experience of a private Pain Unit in Spain date: 2020-09-23 words: 4436 flesch: 35 summary: As the situation continues, the need to reinstate attention for chronic pain patients grows. In the crisis generated by the COVID-19 pandemic, we must agree on the recommendations that guarantee the safety and maintains health care for chronic pain patients. keywords: activity; article; chronic; covid-19; infection; opioids; pain; pandemic; patients; recommendations; system; use cache: cord-331273-1fixwxuo.txt plain text: cord-331273-1fixwxuo.txt item: #2312 of 2876 id: cord-331317-q01uos7a author: Suh, Gee Young title: Early Intervention Can Improve Clinical Outcome of Acute Interstitial Pneumonia date: 2015-12-30 words: 4104 flesch: 42 summary: In our institution, from as early as 1996 our standard approach to ventilating acute lung injury patients was low tidal volume (ie, 6 to 8 mL/kg) with a moderate level of PEEP. The high survival rate of our patients is sharply contrasted with the rate in early reports on AIP patients and is more similar to the rates in more recent reports (Table 3 ). keywords: acute; aip; day; lung; patients; pneumonia; range; therapy cache: cord-331317-q01uos7a.txt plain text: cord-331317-q01uos7a.txt item: #2313 of 2876 id: cord-331434-2x9m37cw author: Kumar Jain, Vijay title: Fracture management during COVID-19 pandemic: A systematic review and meta-analysis date: 2020-06-30 words: 4999 flesch: 50 summary: BMJ evidence-based medicine Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan Is operative delay associated with increased mortality of hip fracture patients? Notingham hip fracture score(NFHS) and clinical frailty score(CFS) added together to make a SHIFT score may be used to select hip fracture cases for surgery in the COVID era, with patient to be considered for non-operative care if the score is more than 12, due to high risk og mortality in this group(53%).The mortality risk was 34% with score 9-12 and just 2% with score less than 9. ASJ Rabie H et al keywords: care; cases; covid; covid-19; emergency; fractures; mortality; pandemic; patients; risk; studies; surgery cache: cord-331434-2x9m37cw.txt plain text: cord-331434-2x9m37cw.txt item: #2314 of 2876 id: cord-331449-0sow1im8 author: Saha, Shivangi title: Managing Burns During COVID-19 Outbreak date: 2020-05-30 words: 2420 flesch: 50 summary: COVID-19: protecting health-care workers Management of elderly burn patients Training | Personal Protective Equipment (PPE) | Public Health Planners | Ebola (Ebola Virus Disease) | CDC COVID-19: the case for health-care worker screening to prevent hospital transmission The incubation period of coronavirus disease 2019 (covid-19) from publicly reported confirmed cases: estimation and application Personal protective equipment during the COVID-19 pandemic-a narrative review Recommendations for the regulation of medical practices of burn treatment during the outbreak of the coronavirus disease 2019 Management strategy of novel coronavirus pneumonia in burn and wound care ward CT imaging features of 2019 novel coronavirus (2019-nCoV) Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR COVID-19: In this review, we aim to highlight the key considerations for burn care teams while dealing with burn patients during the COVID-19 pandemic. keywords: burn; care; coronavirus; covid-19; disease; patients; procedures cache: cord-331449-0sow1im8.txt plain text: cord-331449-0sow1im8.txt item: #2315 of 2876 id: cord-331452-y5lhawqo author: Lentz, Skyler title: High-Risk Airway Management in the Emergency Department: Diseases and Approaches Part I date: 2020-05-12 words: 2868 flesch: 26 summary: 17 Post-intubation cardiac arrest occurs in 150 approximately 2%, though one series reported a higher rate of 4.2% in emergency intubations. 10 151 The reported incidence of cardiac arrest in those with pre-intubation hypotension is even higher 152 at 12-15% of emergency intubations. keywords: airway; emergency; failure; intubation; management; patients; risk cache: cord-331452-y5lhawqo.txt plain text: cord-331452-y5lhawqo.txt item: #2316 of 2876 id: cord-331481-zeaqi1uc author: Al-Ani, Fatimah title: Thrombosis risk associated with COVID-19 infection. A scoping review date: 2020-05-27 words: 4642 flesch: 38 summary: We conducted a scoping review using a single engine search for studies assessing thrombosis and coagulopathy in COVID-19 patients. In case reports of COVID-19 patients, PE was identified in patients with no VTE risk factors 28 . keywords: covid-19; disease; patients; risk; studies; study; survivors; thrombosis cache: cord-331481-zeaqi1uc.txt plain text: cord-331481-zeaqi1uc.txt item: #2317 of 2876 id: cord-331487-jh34klbg author: Sivapalan, Pradeesh title: Proactive Prophylaxis With Azithromycin and HydroxyChloroquine in Hospitalised Patients With COVID-19 (ProPAC-COVID): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-10 words: 6407 flesch: 42 summary: The length of hospitalisation is observed to be relatively long, 10-15 days (3) , which in itself is a problem as hospitals can quickly reach the maximum capacity for hospitalisation and the proportion of patients who become critically ill have, based on the observations reported so far, had a mortality rate of> 60% (4), and overall mortality for admitted patients in China with COVID-19 infection is apparently unusually high for viral respiratory tract infections with an estimate of 25% (2). Annual monitoring after 5 years of treatment is recommended, however in risk patients initially annual control, see also Chloroquine derivatives (inflammatory rheumatic diseases), side effects. keywords: azithromycin; consent; covid-19; data; days; group; hydroxychloroquine; information; intervention; medication; patients; project; study; treatment; trial cache: cord-331487-jh34klbg.txt plain text: cord-331487-jh34klbg.txt item: #2318 of 2876 id: cord-331500-l3hkn2li author: Luyt, Charles-Edouard title: Pulmonary infections complicating ARDS date: 2020-11-11 words: 7549 flesch: 20 summary: However, some preventive measures deserve a special focus in the context of ARDS patients (Fig. 6) : (1) oral care with chlorhexidine is suspected to worsen respiratory failure; (2) selective digestive decontamination (SDD) deserves to be discussed in such high-risk patients, as it has been proven to be effective in reducing mortality in ICU patients and likely lowers VAP rates. Acute respiratory distress syndrome Changes in prevalence of health care-associated infections in US Hospitals Ventilator-associated pneumonia and ICU mortality in severe ARDS patients ventilated according to a lung-protective strategy Ventilator-associated pneumonia in ARDS patients: the impact of prone positioning. keywords: acute; ards; care; ecmo; icu; infection; lung; patients; pneumonia; pulmonary; risk; syndrome; trial; vap; ventilator cache: cord-331500-l3hkn2li.txt plain text: cord-331500-l3hkn2li.txt item: #2319 of 2876 id: cord-331519-ye4dtna5 author: Garibaldi, B. T. title: Patient trajectories and risk factors for severe outcomes among persons hospitalized for COVID-19 in the Maryland/DC region date: 2020-05-26 words: 4523 flesch: 51 summary: Conclusions: A combination of demographic and clinical features on admission is strongly associated with progression to severe disease or death in a US cohort of COVID-19 patients. An elevated D-dimer is associated with increased risk of death in COVID-19 patients independent of documented thromboembolic disease, but could also indicate an increased risk of thrombosis. keywords: author; covid-19; death; disease; funder; medrxiv; patients; peer; preprint; review cache: cord-331519-ye4dtna5.txt plain text: cord-331519-ye4dtna5.txt item: #2320 of 2876 id: cord-331533-0toegbv8 author: Leiker, Brenna title: COVID – 19 CASE STUDY IN EMERGENCY MEDICINE PREPAREDNESS AND RESPONSE; FROM PERSONAL PROTECTIVE EQUIPMENT TO DELIVERGY OF CARE date: 2020-07-27 words: 12834 flesch: 46 summary: Staff was re-allocated to essential areas such as the ED, ICU, home health, and nursing homes to help test and care for COVID patients. The physical space of the emergency room was re-evaluated to best triage and isolate COVID patients. keywords: areas; care; cases; coronavirus; covid; covid-19; emergency; exposure; hospital; intubation; march; mask; northshore; oxygen; pandemic; patients; ppe; protocols; room; staff; testing; time; use cache: cord-331533-0toegbv8.txt plain text: cord-331533-0toegbv8.txt item: #2321 of 2876 id: cord-331547-uqmjhhna author: Bonalumi, Giorgia title: A call to action becomes practice: cardiac and vascular surgery during the COVID-19 pandemic based on the Lombardy emergency guidelines date: 2020-06-25 words: 4239 flesch: 47 summary: A cross-sectional study COVID-19 outbreak In Northern Italy viewpoint of the Milan area surgical community The COVID-19 outbreak and its impact on hospitals in Italy: the model of cardiac surgery Ministero della salute, Italia, National Plan for Hospital Waiting List jsp?lingua=italiano&id=2824 Chinese society of anesthesiology expert consensus on anesthetic management of cardiac surgical patients with suspected or confirmed coronavirus disease 2019 Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 Critically ill COVID-19 infected patients exhibit increased clot waveform analysis parameters consistent with hypercoagulability Associations between immune-suppressive and stimulating drugs and novel COVID-19-a systematic review of current evidence COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension Renin-angiotensin system blockers and the COVID-19 pandemic: at present there is no evidence to abandon renin-angiotensin system blockers Conflict of interest: none declared. Further studies are needed to quantify the number of cardiovascular patients who died of SARS-CoV-2. keywords: area; covid-19; emergency; hospital; hub; patients; results; screening; spoke; system cache: cord-331547-uqmjhhna.txt plain text: cord-331547-uqmjhhna.txt item: #2322 of 2876 id: cord-331604-jf6ybip5 author: Moratto, Daniele title: Flow Cytometry Identifies Risk Factors and Dynamic Changes in Patients with COVID-19 date: 2020-06-27 words: 1908 flesch: 35 summary: Clinical characteristics of coronavirus disease 2019 in China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical course and risk factors for mortality of adult inpatients with COVID-19 in China: a retrospective cohort study Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy Antibody responses to SARS-CoV-2 in patients with COVID-19 Viral kinetics and antibody responses in patients with COVID-19 Complex immune dysregulation in COVID-19 patients with severe respiratory failure Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion Altered monocyte phenotype in HIV-1 infection tends to normalize with integrase-inhibitor-based antiretroviral therapy Inhibition of Bruton tyrosine kinase in patients with severe COVID-10 Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Furthermore, patients with severe disease had a significantly reduced number of TCRγδ + T cells, and an abnormal distribution of CD8 + T cell subsets, with lower proportion of naïve cells and increased percentage of effector CD45RA keywords: admission; clinical; covid-19; disease; patients; phenotype cache: cord-331604-jf6ybip5.txt plain text: cord-331604-jf6ybip5.txt item: #2323 of 2876 id: cord-331762-b0yufidn author: Rudski, Lawrence title: Multimodality Imaging in Evaluation of Cardiovascular complications in Patients with COVID-19 date: 2020-07-22 words: 5051 flesch: 24 summary: Imaging findings typically associated with chronic cardiac conditions such as LVH and LV dilatation, have been well described in acute cardiac presentations of COVID-19 patients and have demonstrated significant reversibility and may not be reliable markers to judge chronicity of cardiac dysfunction (31) . Below are the key summary points from this expert panel guidance regarding the use of multimodality imaging in COVID-19 patients: • TTE is usually the initial cardiovascular imaging modality used to guide management. keywords: acute; cardiac; coronary; covid-19; disease; heart; imaging; injury; management; patients cache: cord-331762-b0yufidn.txt plain text: cord-331762-b0yufidn.txt item: #2324 of 2876 id: cord-331827-amg309uz author: Keske, Şiran title: Human metapneumovirus infection: Diagnostic impact of radiologic imaging date: 2019-02-01 words: 1610 flesch: 34 summary: Radiologic findings of hMPV infection have not been reported to be different from other viral pathogens in studies with high sample sizes; 8 however, it has been reported that studies including radiologic findings of hMPV infections were commonly done among immunocompromised hosts. Clinical LRSI is a syndrome characterized by symptoms consistent with respiratory tract infection (such as fever, cough, sputum, and dyspnea) and lung auscultation findings (crackles, rhonchus, and decreased lung sounds). keywords: findings; hmpv; infection; metapneumovirus; patients cache: cord-331827-amg309uz.txt plain text: cord-331827-amg309uz.txt item: #2325 of 2876 id: cord-331915-7idktu7c author: Cieslak, Theodore J title: A Brief History of Biocontainment date: 2016-10-20 words: 4072 flesch: 39 summary: Singapore and South Korea are currently constructing HLCC facilities, and several Middle Eastern states are exploring this possibility. Although based on very small numbers of patients, the mortality among EVD patients managed in these units was 18 % during the West African outbreak [1••], compared to a casefatality rate of 70 % among all patients and 64 % among patients managed in conventional hospitals (albeit in resource-poor African nations) keywords: biocontainment; care; ebola; facilities; facility; hlcc; infection; laboratory; patients; slammer; units cache: cord-331915-7idktu7c.txt plain text: cord-331915-7idktu7c.txt item: #2326 of 2876 id: cord-332013-bl5d4xkc author: Sánchez-Álvarez, J. Emilio title: Status of SARS-CoV-2 infection in patients on renal replacement therapy Report of the COVID-19 Registry of the Spanish Society of Nephrology (SEN) date: 2020-04-27 words: 3620 flesch: 49 summary: Dialysis patients with SARS-CoV-2 infection have a higher risk of dying than transplant patients, this circumstance is probably related to older age and comorbidity (a variable not recorded in the Registry). Periodic analyzes of the information recorded will be carried out to obtain conclusions about the impact of this infection on RRT patients in Spain and the effect of different strategies dealing with this disease. keywords: cov-2; data; infection; patients; pneumonia; registry; rrt; sars cache: cord-332013-bl5d4xkc.txt plain text: cord-332013-bl5d4xkc.txt item: #2327 of 2876 id: cord-332036-op6s8tr4 author: Feldman, Candace H. title: Widening Disparities Among Patients with Rheumatic Diseases in the COVID‐19 Era: An Urgent Call to Action date: 2020-05-07 words: 1614 flesch: 25 summary: Chicago Sun Times A Prospective Study of the Impact of Current Poverty, History of Poverty, and Exiting Poverty on Accumulation of Disease Damage in Systemic Lupus Erythematosus Racial and ethnic disparities in disease activity in patients with rheumatoid arthritis Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage Lupus Erythematosus Mortality in the United States Association of socioeconomic and demographic factors with utilization of rheumatology subspecialty care in systemic lupus erythematosus Disease Outcomes and Care Fragmentation Among Patients With Systemic Lupus Erythematosus Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Recently, MassHealth, Massachusetts' Medicaid organization, which covers nearly 2 million residents, waived this one-month supply limit, and other states including Illinois, Indiana and Ohio have attempted to preserve hydroxychloroquine access for rheumatology patients. keywords: care; health; lupus; patients cache: cord-332036-op6s8tr4.txt plain text: cord-332036-op6s8tr4.txt item: #2328 of 2876 id: cord-332055-lrpfzsog author: DeVos, Elizabeth title: Approach to Adult Patients with Acute Dyspnea date: 2015-11-27 words: 4420 flesch: 40 summary: Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia Prognostic role of echocardiography among patients with acute pulmonary embolism and a systolic arterial pressure of 90 mm Hg or higher Right ventricular dilatation on bedside echocardiography performed by emergency physicians aids in the diagnosis of pulmonary embolism Critical issues in the evaluation and management of adult patients presenting to the emergency department with suspected pulmonary embolism Usefulness of preemptive anticoagulation in patients with suspected pulmonary embolism: a decision analysis Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer Prospective multicenter evaluation of the pulmonary embolism rule-out criteria Prognostic significance of dyspnea in patients referred for cardiac stress testing Management of emergency department patients with primary spontaneous pneumothorax: needle aspiration or tube thoracostomy? Clinical presentation of patients with tension pneumothorax: a systematic review Metabolic acidosis in the critically ill: part 1. Patients with panic disorder often describe symptoms similar to those of patients with true airway obstruction despite their normal pulmonary function. keywords: acute; breath; cardiac; chest; dyspnea; lung; management; patients; pneumonia; respiratory; symptoms cache: cord-332055-lrpfzsog.txt plain text: cord-332055-lrpfzsog.txt item: #2329 of 2876 id: cord-332087-xwturwju author: McGlynn, Fergal title: Argatroban for therapeutic anticoagulation for heparin resistance associated with Covid-19 infection date: 2020-08-24 words: 1451 flesch: 49 summary: They recommend LMWH or UFH for therapeutic anticoagulation, for any indication, over direct oral anticoagulation (DOAC), and recommend considering measuring anti-Xa levels for anticoagulant monitoring. They also recommend measuring anti-Xa levels in patients with Covid-19 who are anticoagulated with heparin. keywords: anti; covid-19; heparin; patients cache: cord-332087-xwturwju.txt plain text: cord-332087-xwturwju.txt item: #2330 of 2876 id: cord-332145-rw16o02g author: Chen, Patrick M. title: Evolving Healthcare Delivery in Neurology During the Coronavirus Disease 2019 (COVID-19) Pandemic date: 2020-05-29 words: 2969 flesch: 39 summary: An important task moving forward is to be methodical in our collection of data for COVID-19 neurologic patients if we are the truly understand its role in the central nervous system. Acute stroke alerts present the most direct potential interface with COVID-19 patients. keywords: care; covid-19; disease; hospital; pandemic; patients; risk; stroke; telemedicine cache: cord-332145-rw16o02g.txt plain text: cord-332145-rw16o02g.txt item: #2331 of 2876 id: cord-332150-j76726no author: De Stefano, Ludovico title: A “Window of Therapeutic Opportunity” for Anti-Cytokine Therapy in Patients With Coronavirus Disease 2019 date: 2020-10-06 words: 3623 flesch: 9 summary: Microorganisms Efficacy and safety of tocilizumab in severe COVID-19 patients: a singlecentre retrospective cohort study Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized COVID-19 Patients: Survival and Clinical Outcomes Profiling COVID-19 pneumonia progressing into the cytokine storm syndrome: Results from a single Italian Centre study on tocilizumab versus standard of care Safety and efficacy of anti-il6-receptor tocilizumab use in severe and critical patients affected by coronavirus disease 2019: A comparative analysis Early use of low dose tocilizumab in patients with COVID-19: A retrospective cohort study with a complete follow-up Tocilizumab in patients with severe COVID-19: a retrospective cohort study Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study Anakinra for severe forms of COVID-19: a cohort study Beneficial impact of Baricitinib in COVID-19 moderate pneumonia; multicentre study Efficacy Evaluation of Early, Low-Dose, Short-Term Corticosteroids in Adults Hospitalized with Non-Severe COVID-19 Pneumonia: A Retrospective Cohort Study Effect of Systemic Glucocorticoids on Mortality or Mechanical Ventilation in Patients With COVID-19 Factors associated with COVID-19-related death using OpenSAFELY The role of host genetics in the immune response to SARS-CoV-2 and COVID-19 susceptibility and severity Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection Viral and host factors related to the clinical outcome of COVID-19 Hypothesis for potential pathogenesis of SARSCoV-2 infection -a review of immune changes in patients with viral pneumonia COVID-19: immunopathology and its implications for therapy The Many Faces of the anti-COVID Immune Response Clinical and immunologic features in severe and moderate forms of Coronavirus Disease SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion Functional exhaustion of antiviral lymphocytes in COVID-19 patients Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. keywords: covid-19; cytokine; disease; patients; sars; study; syndrome; tocilizumab cache: cord-332150-j76726no.txt plain text: cord-332150-j76726no.txt item: #2332 of 2876 id: cord-332153-fczf3lzc author: Azkur, Ahmet Kursat title: Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19 date: 2020-05-12 words: 6190 flesch: 41 summary: Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Cell-free hemoglobin: a novel mediator of acute lung injury The Acute Respiratory Distress Syndrome: Mechanisms and Perspective Therapeutic Approaches Management of Critically Ill Adults With COVID-19 Treatment for severe acute respiratory distress syndrome from COVID-19 Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma An inhaled tumor necrosis factor-alpha-derived TIP peptide improves the pulmonary function in experimental lung injury The clinical pathology of severe acute respiratory syndrome (SARS): a report from Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates Autopsy in suspected COVID-19 cases Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19 Clinical characteristics of 25 death cases with COVID-19: a retrospective review of medical records in a single medical center Liver impairment in COVID-19 patients: a retrospective analysis of 115 cases from a single center in Wuhan city Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis Kidney disease is associated with in-hospital death of patients with COVID-19 Accepted Article 15 Anticoagulation therapy is recommended for COVID-19 patients, when the D- This article is protected by copyright. keywords: acute; article; cells; copyright; coronavirus; cov-2; covid-19; cytokine; disease; patients; rights; sars; storm cache: cord-332153-fczf3lzc.txt plain text: cord-332153-fczf3lzc.txt item: #2333 of 2876 id: cord-332180-dw4h69tp author: Cheng, Fu-Yuan title: Using Machine Learning to Predict ICU Transfer in Hospitalized COVID-19 Patients date: 2020-06-01 words: 4130 flesch: 39 summary: The non-ICU bed to ICU transfer rate in our cohort was 3.7 percent, which created an extreme class imbalance between the majority class (feature vectors without the occurrence of ICU transfer within 24 h) and the minority class (feature vectors with ICU transfer within 24 h). Low sample size and class imbalance resulting from low ICU transfer rates are major limitations to this version of the model, which resulted in low precision. keywords: care; cohort; covid-19; data; icu; model; patients; risk; transfer; variables cache: cord-332180-dw4h69tp.txt plain text: cord-332180-dw4h69tp.txt item: #2334 of 2876 id: cord-332233-01rdlf8l author: Tully, Thomas N. title: CHAPTER 12 MICE AND RATS date: 2009-12-31 words: 12450 flesch: 54 summary: Inducing and maintaining mouse patients under anesthesia can be very challenging. Therefore, inhalant anesthetic agents (e.g., isofl urane, sevofl urane) are recommended for anesthetizing mouse patients. keywords: animals; blood; cage; disease; examination; hair; mice; mouse; parasites; patient; rats; rodents; skin; treatment; urine; virus; water cache: cord-332233-01rdlf8l.txt plain text: cord-332233-01rdlf8l.txt item: #2335 of 2876 id: cord-332278-2p64ab2z author: Vivas, David title: Recomendaciones sobre el tratamiento antitrombótico durante la pandemia COVID-19. Posicionamiento del Grupo de Trabajo de Trombosis Cardiovascular de la Sociedad Española de Cardiología date: 2020-06-19 words: 3080 flesch: 42 summary: Furthermore, although primary angioplasty is the preferred reperfusion strategy in patients with ST-segment elevation acute myocardial infarction, fibrinolysis can be considered in patients with an estimated time from diagnosis to coronary intervention of more than 120 minutes, in infected patients with poor clinical status that hinders transfer, or in those at low risk of bleeding and with symptom onset less than 3 hours previously. In addition, the situation has also greatly influenced usual care in patients not infected with COVID-19. keywords: cov-2; drugs; lmwh; patients; risk; sars; therapy cache: cord-332278-2p64ab2z.txt plain text: cord-332278-2p64ab2z.txt item: #2336 of 2876 id: cord-332480-3uodkrkp author: Bonam, Srinivasa Reddy title: Adjunct immunotherapies for the management of severely ill COVID-19 patients date: 2020-04-30 words: 5451 flesch: 35 summary: 12, 13 Plasma obtained from COVID-19 patients, in particular moribund patients, demonstrated increased concentrations of various inflammation-related cytokines and chemokines implicated in the recruitment of immune cells including interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-2, IL-6, IL-7, IL-8, IL-9, IL-17, granulocyte-colony stimulating factor (G-CSF), granulocytemacrophage colony-stimulating factor (GM-CSF), interferon (IFN)-γ, C-X-C motif chemokine 10 (CXCL10), chemokine ligand 2 (CCL2), CCL3 and CCL4. 1, 14, 15 In addition, COVID-19 patients showed relatively increased neutrophil counts in the blood. keywords: antibody; cells; cov-2; covid-19; disease; patients; plasma; sars; syndrome; therapy; treatment; viral cache: cord-332480-3uodkrkp.txt plain text: cord-332480-3uodkrkp.txt item: #2337 of 2876 id: cord-332650-05oz5zwz author: Fiorelli, Silvia title: Perspectives in surgical and anaesthetic management of lung cancer in the era of coronavirus disease 2019 (COVID-19) date: 2020-08-26 words: 3277 flesch: 33 summary: Alternatively, some hospitals should be committed to treating COVID-19 patients exclusively (hub hospitals), whereas other medical centres can continue to treat ordinary non-infected cases (COVID-19-free spoke hospitals) Particulate respirators, designed to block 95-99% of aerosol particles and recommended during management of COVID-19 patients, should be routinely used during thoracic anaesthesia. keywords: cancer; covid-19; lung; management; pandemic; patients; surgery; thoracic cache: cord-332650-05oz5zwz.txt plain text: cord-332650-05oz5zwz.txt item: #2338 of 2876 id: cord-332709-0plblo4k author: Zodda, David title: Optimizing Non-invasive Oxygenation for COVID-19 Patients Presenting to the Emergency Department with Acute Respiratory Distress: A Case Report date: 2020-06-22 words: 2378 flesch: 46 summary: With limited resources and ventilators available, emergency physicians working at a hospital within the epicenter of the United States outbreak developed a stepwise, non-invasive oxygenation strategy for treating COVID-19 patients presenting with severe hypoxia and acute respiratory distress. Our case highlights a stepwise, organized approach to providing non-invasive oxygenation for COVID-19 patients presenting with severe hypoxia and acute respiratory distress. keywords: covid-19; non; oxygen; oxygenation; patients cache: cord-332709-0plblo4k.txt plain text: cord-332709-0plblo4k.txt item: #2339 of 2876 id: cord-332774-t5untewz author: Vaccaro, Alexander R. title: Practice Management During the COVID-19 Pandemic date: 2020-04-13 words: 4905 flesch: 44 summary: As Pennsylvania may be one of the first states to peek, plateau, and subside with the COVID-19 surge, this puts the regional policies and group practices in position to model a restart plan. The suddenness of this mandate and the concomitant spread of the COVID-19 virus left many hospital systems, orthopaedic practices, and patients with notable anxiety and confusion as to the near, intermediate, and long-term future of our healthcare system. keywords: benefits; covid-19; employees; groups; office; patients; period; practice; providers; salary; staff; time cache: cord-332774-t5untewz.txt plain text: cord-332774-t5untewz.txt item: #2340 of 2876 id: cord-332778-rf47ptj6 author: Vivarelli, Silvia title: Cancer Management during COVID-19 Pandemic: Is Immune Checkpoint Inhibitors-Based Immunotherapy Harmful or Beneficial? date: 2020-08-10 words: 7465 flesch: 40 summary: key: cord-332778-rf47ptj6 authors: Vivarelli, Silvia; Falzone, Luca; Grillo, Caterina Maria; Scandurra, Giuseppa; Torino, Francesco; Libra, Massimo title: Cancer Management during COVID-19 Pandemic: Is Immune Checkpoint Inhibitors-Based Immunotherapy Harmful or Beneficial? date: 2020-08-10 journal: Cancers (Basel) DOI: 10.3390/cancers12082237 sha: doc_id: 332778 cord_uid: rf47ptj6 The coronavirus disease 2019 (COVID-19) is currently representing a global health threat especially for fragile individuals, such as cancer patients. It was demonstrated that cancer patients have an increased risk of developing a worse symptomatology upon severe acute respiratory syndrome associated coronavirus-2 (SARS-CoV-2) infection, often leading to hospitalization and intensive care. keywords: cancer; cancer patients; cov-2; covid-19; icis; immune; infection; pandemic; patients; sars; study cache: cord-332778-rf47ptj6.txt plain text: cord-332778-rf47ptj6.txt item: #2341 of 2876 id: cord-332788-8lq9qygn author: Manda, Sudhir title: Feasibility of Long-Term Proteasome Inhibition in Multiple Myeloma by In-Class Transition from Bortezomib to Ixazomib date: 2020-07-06 words: 4420 flesch: 43 summary: [24] suggest that the effectiveness of extended treatment with ixazomib-Rd appears similar to efficacy reported in clinical trials, 25 and that the combination is well tolerated with low rates of grade 3/4 PN. 19, 20, 25 The US MM-6 study is investigating the novel iCT approach with the aim of increasing PI-based treatment duration and adherence, maintaining HRQoL, and improving outcomes in NDMM patients, with a study design that allows centers to follow their standard-of-care procedures for first-line bortezomib-based induction therapy. The US MM-6 study was therefore designed to evaluate a novel iCT approach in the community-based setting with the aims of increasing PI-based treatment duration and adherence, maintaining HRQoL, and improving outcomes in a representative, real-world, community population of NDMM patients. keywords: bortezomib; data; ixazomib; patients; study; therapy; treatment cache: cord-332788-8lq9qygn.txt plain text: cord-332788-8lq9qygn.txt item: #2342 of 2876 id: cord-332861-7b5pzmk6 author: Zhang, Zhan title: Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases date: 2020-02-07 words: 2085 flesch: 58 summary: It is speculated that the number of immune cells in the blood decreased due to a large number of them were lost or exuded to the infectious site to participate in the body's defense response. In this study, the male had a more severe decrease in immune cells and more severe conditions than the female. keywords: cells; female; patient; symptoms; urine cache: cord-332861-7b5pzmk6.txt plain text: cord-332861-7b5pzmk6.txt item: #2343 of 2876 id: cord-332992-8rmqg4rf author: de Vries, A. A. F. title: SARS-CoV-2/COVID-19: a primer for cardiologists date: 2020-07-15 words: 9215 flesch: 31 summary: Front Public Health Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection Complement as a target in COVID-19? COVID-19: immunopathology and its implications for therapy Immune-inflammatoryparameters in COVID-19 cases: a systematic review and meta-analysis AntibodyresponsestoSARS-CoV-2 in patients with COVID-19 IgA-Ab response to spike glycoprotein of SARS-CoV-2 in patients with COVID-19: a longitudinal study Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals Diagnostic testing for severe acute respiratory syndrome-related coronavirus 2: a narrative review Towards effective diagnostic assays for COVID-19: a review Coronavirus pandemic-therapy and vaccines Vaccines for SARS-CoV-2: lessons from other coronavirus strains AreviewofSARS-CoV-2 and the ongoing clinical trials Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization The challenges of vaccine development against a new virus during a pandemic The current and future state of vaccines, antivirals and gene therapies against emerging coronaviruses A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease COVID-19: Transmission, prevention, and potential therapeutic opportunities Renin-angiotensin system inhibition in COVID-19 patients A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: efficacy, safety and clinical trials The possible mechanisms of action of 4-aminoquinolines (chloroquine/hydroxychloroquine) against SARS-CoV-2 infection (COVID-19): a role for iron homeostasis? Based on previous research on SARS-CoV and MERS-CoV and various animal models of virus-induced acute lung injury as well as haematological and biochemical laboratory findings in COVID-19 patients, the following scenarios can be envisioned [33, 34, 48, 49] . keywords: antibody; cells; coronavirus; cov-2; covid-19; disease; human; immune; infection; injury; onset; particles; patients; protein; rna; sars; transmission; vaccines; viral; virus cache: cord-332992-8rmqg4rf.txt plain text: cord-332992-8rmqg4rf.txt item: #2344 of 2876 id: cord-333024-1yrmun3z author: von Lilienfeld-Toal, Marie title: Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology date: 2016-09-25 words: 6272 flesch: 28 summary: The emergency use authorization of peramivir for treatment of 2009 H1N1 influenza Ribavirin therapy in bone marrow transplant recipients with viral respiratory tract infections Management of RSV infections in adult recipients of hematopoietic stem cell transplantation Oral ribavirin therapy for respiratory syncytial virus infections in moderately to severely immunocompromised patients Impact of aerosolized ribavirin on mortality in 280 allogeneic haematopoietic stem cell transplant recipients with respiratory syncytial virus infections An outbreak of respiratory syncytial virus infection in hematopoietic stem cell transplantation outpatients: good outcome without specific antiviral treatment The natural history of respiratory syncytial virus infection in cancer and transplant patients: implications for management Congenital anomalies induced in hamster embryos with ribavirin Oral ribavirin for treatment of respiratory syncitial virus and parainfluenza 3 virus infections post allogeneic haematopoietic stem cell transplantation Successful systemic high-dose ribavirin treatment of respiratory syncytial virus-induced infections occurring preengraftment in allogeneic hematopoietic stem cell transplant recipients Control of an outbreak of human parainfluenza virus 3 in hematopoietic stem cell transplant recipients Parainfluenza virus type 3 infections in a hematology unit Donor leukocyte infusion as therapy of life-threatening adenoviral infections after T-cell-depleted bone marrow transplantation First-in-man clinical results with good manufacturing practice (GMP)-compliant polypeptide-expanded adenovirus-specific T cells after haploidentical hematopoietic stem cell transplantation Human metapneumovirus infection after allogeneic hematopoietic stem cell transplantation Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients RNA respiratory viral infections in solid organ transplant recipients Comparison of four clinical specimen types for detection of influenza A and B viruses by optical immunoassay (FLU OIA test) and cell culture methods Performance of virus isolation and Directigen Flu A to detect influenza A virus in experimental human infection Comparison of nasopharyngeal flocked swabs and nasopharyngeal wash collection methods for respiratory virus detection in hospitalized children using real-time polymerase chain reaction Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses Comparison among nasopharyngeal swab, nasal wash, and oropharyngeal swab for respiratory virus detection in adults with acute pharyngitis RSV testing in bronchiolitis: which nasal sampling method is best? Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction Comparative study of nasopharyngeal aspirate and nasal swab specimens for diagnosis of acute viral respiratory infection Comparison of sampling methods for the detection of human rhinovirus RNA Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding Evaluation of the Prodesse Hexaplex multiplex PCR assay for direct detection of seven respiratory viruses in clinical specimens Rapid identification viruses from nasal pharyngeal aspirates in acute viral respiratory infections by RT-PCR and electrospray ionization mass spectrometry Pulmonary imaging of pandemic influenza H1N1 infection: relationship between clinical presentation and disease burden on chest radiography and CT Confirmed swine-origin influenza A(H1N1) viral pneumonia: computed tomographic findings in the immunocompetent and the immunocompromised 64 multidetector CT findings of influenza A (H1N1) virus in patients with hematologic malignancies Thoracic CT findings of novel influenza A (H1N1) infection in immunocompromised patients CT manifestations of respiratory syncytial virus infection in lung transplant recipients Pulmonary manifestation of novel swine-origin influenza A (H1N1) virus (S-OIV) infection in immunocompromised patients: initial findings with multidetector computed tomography Radiographic and highresolution CT findings of influenza virus pneumonia in patients with hematologic malignancies Human metapneumovirus (HMPV) associated pulmonary infections in immunocompromised adultseinitial CT findings, disease course and comparison to respiratory-syncytial-virus (RSV) induced pulmonary infections Physical interventions to interrupt or reduce the spread of respiratory viruses Contributing and terminating factors of a large RSV outbreak in an Adult Hematology and Transplant Unit Current management of parainfluenza pneumonitis in immunocompromised patients: a review Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation Disseminated adenovirus infections after allogeneic hematopoietic stem cell transplantation: incidence, risk factors and outcome Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children Description of an adenovirus A31 outbreak in a paediatric haematology unit Biopsy-proven adenoviral diarrhea responding to low-dose cidofovir The authors thank Ramona Kraft for technical assistance with the retrieval of full papers. key: cord-333024-1yrmun3z authors: von Lilienfeld-Toal, Marie; Berger, Annemarie; Christopeit, Maximilian; Hentrich, Marcus; Heussel, Claus Peter; Kalkreuth, Jana; Klein, Michael; Kochanek, Matthias; Penack, Olaf; Hauf, Elke; Rieger, Christina; Silling, Gerda; Vehreschild, Maria; Weber, Thomas; Wolf, Hans-Heinrich; Lehners, Nicola; Schalk, Enrico; Mayer, Karin title: Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology date: 2016-09-25 journal: keywords: cancer; cell; crv; evidence; infection; influenza; patients; recipients; stem; table; transplantation; treatment; use; virus cache: cord-333024-1yrmun3z.txt plain text: cord-333024-1yrmun3z.txt item: #2345 of 2876 id: cord-333113-0k6xlmem author: Tran, V.-T. title: Association between corticosteroids and intubation or death among patients with COVID-19 pneumonia in non-ICU settings: an observational study using of real-world data from 51 hospitals in France and Luxembourg date: 2020-09-18 words: 5879 flesch: 51 summary: Fourth, identification of patients eligible in the study was performed manually with a patient-by-patient screening of all patients hospitalized in the study centres within the study dates. key: cord-333113-0k6xlmem authors: Tran, V.-T.; Mahevas, M.; Bani Sadr, F.; Robineau, O.; Perpoint, T.; Perrodeau, E.; Gallay, L.; Ravaud, P.; Goehringer, F.; Lescure, X.; COCORICO, title: Association between corticosteroids and intubation or death among patients with COVID-19 pneumonia in non-ICU settings: an observational study using of real-world data from 51 hospitals in France and Luxembourg date: 2020-09-18 journal: nan DOI: 10.1101/2020.09.16.20195750 sha: doc_id: 333113 cord_uid: 0k6xlmem Objective To assess the effectiveness of corticosteroids on outcomes of patients with mild COVID-19 pneumonia. keywords: corticosteroids; ctc; ctc group; day; group; license; patients; preprint cache: cord-333113-0k6xlmem.txt plain text: cord-333113-0k6xlmem.txt item: #2346 of 2876 id: cord-333142-ek7hct52 author: Patel, Shivani A. title: The Integrated Tracking, Referral, and Electronic Decision Support, and Care Coordination (I-TREC) program: scalable strategies for the management of hypertension and diabetes within the government healthcare system of India date: 2020-11-09 words: 6258 flesch: 35 summary: A second measure of reach is the number of patients seeking care for hypertension and diabetes who have an eCRF, which will be measured through health facility data. Using patient health data from the eCRF, we will assess processes of care and changes in blood pressure and blood glucose outcomes over time among patients with hypertension or diabetes who seek care at I-TREC program facilities in a facility-based evaluation component. keywords: care; community; data; diabetes; ecrf; facilities; facility; health; healthcare; hypertension; india; patient; program; system; trec cache: cord-333142-ek7hct52.txt plain text: cord-333142-ek7hct52.txt item: #2347 of 2876 id: cord-333175-klnxnxwm author: Hussein, Mohammad H. title: Asthma in COVID-19 patients: An extra chain fitting around the neck? date: 2020-11-11 words: 2656 flesch: 45 summary: Univariate analysis revealed that asthma patients were more likely to be obese (75% versus 54.2%, p = 0.001), with a higher frequency of intubation (40.3% versus 27.8%, p = 0.036), and required a longer duration of hospitalization (15.1 ± 12.5 versus 11.5 ± 10.6, p = 0.015). key: cord-333175-klnxnxwm authors: Hussein, Mohammad H.; Toraih, Eman A.; Attia, Abdallah S.; Burley, Nicholas; Zhang, Allen D.; Roos, Jackson; Houghton, August; Aniemeka, Nedum; Omar, Mahmoud; Aboueisha, Mohamed; Shama, Mohamed A.; Duchesne, Juan; Kandil, Emad title: Asthma in COVID-19 patients: An extra chain fitting around the neck? date: 2020-11-11 journal: keywords: asthma; asthmatic; covid-19; disease; outcomes; patients cache: cord-333175-klnxnxwm.txt plain text: cord-333175-klnxnxwm.txt item: #2348 of 2876 id: cord-333183-xyuj1j57 author: Lee, Lennard Y W title: COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study date: 2020-05-28 words: 4496 flesch: 40 summary: Mortality from COVID-19 in cancer patients appears to be principally driven by age, gender, and comorbidities. We are not able to identify evidence that cancer patients on cytotoxic chemotherapy or other anticancer treatment are at an increased risk of mortality from COVID-19 disease compared with those not on active treatment. keywords: anticancer; cancer; chemotherapy; covid-19; data; mortality; patients; risk; treatments cache: cord-333183-xyuj1j57.txt plain text: cord-333183-xyuj1j57.txt item: #2349 of 2876 id: cord-333340-ekok0mp5 author: Graf, Erin H. title: Appropriate Use and Future Directions of Molecular Diagnostic Testing date: 2020-02-06 words: 5779 flesch: 24 summary: Another randomized controlled trial found no difference in length of stay or antibiotic usage, including duration, comparing adult patients who received syndromic panel testing with those who received conventional microbiologic testing [16] . However, retrospective analyses have the benefit of knowing the final diagnosis while at the time of clinical presentation, it may have been appropriate to order syndromic panel testing [43] . keywords: care; clinical; detection; impact; molecular; panel; patients; sequencing; stewardship; studies; testing; time cache: cord-333340-ekok0mp5.txt plain text: cord-333340-ekok0mp5.txt item: #2350 of 2876 id: cord-333375-d7cgvjsm author: Phoon, Laiyee title: Recommendations on diagnosis and treatment in hepatobiliary surgery under 2019-nCoV epidemic date: 2020-06-12 words: 2348 flesch: 38 summary: Most hepatobiliary diseases are associated with metabolic disorders, and the 2019-nCoV virus has been shown to have a detrimental effect on liver function, and sometimes can cause severe conditions and even death in patients [11] . Therefore, it is critical to talk with patient and learn about their epidemiological history. keywords: coronavirus; diagnosis; ncov; patients; surgery; treatment cache: cord-333375-d7cgvjsm.txt plain text: cord-333375-d7cgvjsm.txt item: #2351 of 2876 id: cord-333429-bq7kfpby author: Shi, Ding title: Clinical characteristics and factors associated with long-term viral excretion in patients with SARS-CoV-2 infection: a single center 28-day study date: 2020-07-02 words: 3517 flesch: 49 summary: Underlying diseases has been shown to be related to prolonged viral shedding in SARS patients [6] . Several studies have reported that the use of corticosteroids is associated with delayed viral RNA clearance in MERS or SARS patients and even with higher mortality in influenza pneumonia keywords: group; patients; rna; sars; shedding; virus cache: cord-333429-bq7kfpby.txt plain text: cord-333429-bq7kfpby.txt item: #2352 of 2876 id: cord-333451-p2plpeew author: Raab, Anja M. title: Significant demands on healthcare resources during the COVID crisis date: 2020-05-13 words: 957 flesch: 46 summary: Positioning and mobilization are effective methods of respiratory therapy. There are various methods and devices for respiratory therapy with different objectives. keywords: care; covid-19; patients; respiratory cache: cord-333451-p2plpeew.txt plain text: cord-333451-p2plpeew.txt item: #2353 of 2876 id: cord-333453-v3gap8kj author: Dima, Mirabela title: First neonates with severe acute respiratory syndrome coronavirus 2 infection in Romania: Three case reports date: 2020-08-14 words: 3022 flesch: 44 summary: A novel coronavirus from patients with pneumonia in China Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and metaanalysis SARS-CoV-2 infection in children Epidemiology of COVID-19 among children in China Kawasaki-like disease: emerging complication during the COVID-19 pandemic A case report of neonatal acute respiratory failure due to SARS-CoV-2 Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults First case of neonate infected with novel coronavirus pneumonia in China National Institute of Public Health Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: a review Severe COVID-19 during pregnancy and possible vertical transmission Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia Detection of SARS-CoV-2 in human breastmilk Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation Flowchart showing the reverse transcription polymerase chain reaction test results of the newborns and their mothers Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up Epidemiology and prevention of neonatal candidiasis: fluconazole for all neonates? [9] In Romania, at the moment the official national registry for COVID-19 cases states that the group age 0 to 9 years accounts for approximately 2.5% of the cases. keywords: candidiasis; cases; cov-2; covid-19; patients; sars cache: cord-333453-v3gap8kj.txt plain text: cord-333453-v3gap8kj.txt item: #2354 of 2876 id: cord-333470-0a0i6vjn author: Lombe, Dorothy C title: Zambia’s National Cancer Centre response to the COVID-19 pandemic—an opportunity for improved care date: 2020-05-28 words: 3350 flesch: 44 summary: This COVID-19 crisis is being seen as an opportunity to develop a robust referral system so that cancer patients do not have to wait for treatment in Lusaka or travel to and fro across the country but instead arrive for scheduled visits. The adjustment of workflows due to the epidemic has seen positive shifts in some aspects of service delivery for cancer patients in this low middle-income country ( Figure 1 ). keywords: cancer; care; cases; centre; covid-19; health; pandemic; patients; staff; treatment cache: cord-333470-0a0i6vjn.txt plain text: cord-333470-0a0i6vjn.txt item: #2355 of 2876 id: cord-333528-9mczqtje author: Mattogno, P. P. title: Transnasal endoscopic skull base surgery during COVID-19 pandemic: algorithm of management in an Italian reference COVID center date: 2020-06-03 words: 1076 flesch: 40 summary: In patients requiring urgent surgery, we adopted our Institutional protocol for surgical emergencies in COVID+ patients. Encouraging and implementing strict protection measures to providers and patients will prevent the further spreading of the COVID-19 infection in hospital settings where the care to selected patient requiring urgent surgery must continue. keywords: covid-19; endoscopic; patients; surgery cache: cord-333528-9mczqtje.txt plain text: cord-333528-9mczqtje.txt item: #2356 of 2876 id: cord-333588-3krh1xzx author: Sharma, Amita title: Pediatric Dentistry during Coronavirus Disease-2019 Pandemic: A Paradigm Shift in Treatment Options date: 2020 words: 2601 flesch: 51 summary: 14 Pulpectomies in primary teeth should be avoided as it might require multiple sittings depending on the clinical condition of the tooth and extensive instrumentation during biomechanical preparation shall increase patient and dentist's contact time. In case of avulsion of primary tooth, control of bleeding should be the main mode of treatment followed by pain management of the child. keywords: case; dentistry; patient; pediatric; pulp; tooth; treatment cache: cord-333588-3krh1xzx.txt plain text: cord-333588-3krh1xzx.txt item: #2357 of 2876 id: cord-333654-8rg99di5 author: Pillai, Presaad title: COVID-19 AND MAJOR ORGAN THROMBOEMBOLISM: MANIFESTATIONS IN NEUROVASCULAR AND CARDIOVASCULAR SYSTEMS. date: 2020-10-24 words: 4130 flesch: 30 summary: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis Procoagulant activity during viral infections Targeting the cytokine storm for therapeutic benefit Modulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory Drugs Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Pandemic H1N1 Influenza Infection and Vascular Thrombosis PAMPs and DAMPs as triggers for DIC Disseminated intravascular coagulation Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia COVID-19 coagulopathy: an indepth analysis of the coagulation system D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19 Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past A major outbreak of severe acute respiratory syndrome in Hong Kong Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected with Pulmonary CT Angiography The clinical pathology of severe acute respiratory syndrome (SARS): a report from China Immunohistochemical, and Ultrastructural Findings of a Fatal Case of Middle East Respiratory Syndrome Coronavirus Infection in the United Arab Emirates Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19 Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Extremely High Incidence of Lower Extremity Deep Venous Thrombosis in 48 Patients With Severe COVID-19 in Wuhan Incidence and associated factors of deep vein thrombosis in Thai surgical ICU patients without chemoprophylaxis: one year study Deep Vein Thrombosis among Intensive Care Unit Patients Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients Acute cerebrovascular disease following COVID-19: a single center, retrospective, observational study COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: Characteristics of ischaemic stroke associated with COVID-19 COVID-19 and the cardiovascular system Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Cardiovascular manifestations and treatment considerations in COVID-19 Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Risk of peripheral arterial thrombosis in COVID-19 Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) ST-Elevation Myocardial Infarction in Patients With COVID-19: keywords: coronavirus; covid-19; dimer; disease; patients; pulmonary; sars; thromboembolism; thrombosis cache: cord-333654-8rg99di5.txt plain text: cord-333654-8rg99di5.txt item: #2358 of 2876 id: cord-333684-j1sg46w9 author: Filippi, Federica title: COVID‐19 era: A chance to learn something new about monitoring psoriatic patients in biological therapy date: 2020-06-10 words: 796 flesch: 29 summary: Non-urgent blood tests were also suspended, including monitoring in psoriatic patients undergoing biological therapy 7 . If this is not so, it could be the starting point for a further lengthening of the monitoring time of psoriatic patients considered responders to biological therapy. keywords: months; patients; therapy cache: cord-333684-j1sg46w9.txt plain text: cord-333684-j1sg46w9.txt item: #2359 of 2876 id: cord-333688-bykbyojs author: Wang, Junxue title: Persistent SARS-COV-2 RNA positivity in a patient for 92 days after disease onset: A case report date: 2020-08-21 words: 2622 flesch: 45 summary: Positive viral nucleic acid test results show remaining viral genetic activity in these patients, and there have been reports of infectious viruses isolated from patient samples However, his nucleic acid test result was positive on Day 92 after discharge, showing that the aforementioned antiviral regimen did not have significant effects on the negative conversion of nucleic acid tests results. keywords: acid; cov-2; nucleic; patient; sars cache: cord-333688-bykbyojs.txt plain text: cord-333688-bykbyojs.txt item: #2360 of 2876 id: cord-333696-3ci9re9a author: Alomari, Safwan O. title: COVID-19 and the Central Nervous System date: 2020-08-04 words: 4426 flesch: 40 summary: We believe that this association between smoking and COVID-19 neurological manifestations, if proven, might be of great impact, since all the people worldwide are currently at high risk of being exposed to smoking and COVID-19 infection. Patients with COVID-19 infection should be evaluated early for neurological symptoms. keywords: acute; brain; case; coronavirus; cov-2; covid-19; disease; encephalitis; infection; patients; sars cache: cord-333696-3ci9re9a.txt plain text: cord-333696-3ci9re9a.txt item: #2361 of 2876 id: cord-333698-e73d9lbu author: Lechien, Jerome R. title: Features of Mild-to-Moderate COVID-19 Patients with Dysphonia. date: 2020-06-04 words: 1774 flesch: 47 summary: The prevalence of the following symptoms was higher in dysphonic patients compared with non-dysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea and vomiting. To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients. keywords: covid-19; dysphonia; group; pain; patients; symptoms cache: cord-333698-e73d9lbu.txt plain text: cord-333698-e73d9lbu.txt item: #2362 of 2876 id: cord-333749-45v6b4tc author: Xie, Guogang title: The role of peripheral blood eosinophil counts in COVID‐19 patients date: 2020-06-20 words: 4006 flesch: 51 summary: Fatigue was more common in COVID-19 patients, suspected patients and influenza pneumonia patients than other types of pneumonia patients (66.7%, 58.3%, 66.7% vs 39.8%). All rights reserved severe patients and 9 severe patients had been discharged, while three severe patients had received mechanical ventilation and one of them had died finally. keywords: article; blood; copyright; counts; covid-19; eos; patients; pneumonia cache: cord-333749-45v6b4tc.txt plain text: cord-333749-45v6b4tc.txt item: #2363 of 2876 id: cord-333808-deifddar author: McGregor, Bradley A title: Remote Oncology Care: Review of Current Technology and Future Directions date: 2020-08-31 words: 3283 flesch: 24 summary: Cancer stat facts: cancer of any site Hospitalizations during systemic therapy for metastatic lung cancer: a systematic review of real world vs clinical trial outcomes Impact of observation status on hospital use for patients with cancer Hospitalisations and emergency department visits in cancer patients receiving systemic therapy: systematic review and metaanalysis Hospital admission of cancer patients: avoidable practice or necessary care Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients Treatment-related complications of systemic therapy and radiotherapy The future of wearable technologies and remote monitoring in health care Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial Cryptogenic stroke and underlying atrial fibrillation Two-year survival comparing web-based symptom monitoring vs routine surveillance following treatment for lung cancer Cost-effectiveness of web-based patient-reported outcome surveillance in patients with lung cancer Overall survival results of a trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial Cancer patient care during COVID-19 Managing cancer care during the COVID-19 pandemic: agility and collaboration toward a common goal Coronavirus: what people with cancer should know Automated home monitoring and management of patient-reported symptoms during chemotherapy: results of the symptom care at home RCT Enhancing patient-provider communication with the electronic self-report assessment for cancer: a randomized trial Automated symptom alerts reduce postoperative symptom severity after cancer surgery: a randomized controlled clinical trial A randomized trial of the electronic Lung Cancer Symptom Scale for quality-of-life assessment in patients with advanced non-small-cell lung cancer The effect of real-time electronic monitoring of patient-reported symptoms and clinical syndromes in outpatient workflow of medical oncologists: E-MOSAIC, a multicenter cluster-randomized phase III study (SAKK 95/06) Electronic self-report assessment for cancer and selfcare support: results of a multicenter randomized trial Effects of an internet support system to assist cancer patients in reducing symptom distress: a randomized controlled trial A mobile app to stabilize daily functional activity of breast cancer patients in collaboration with the physician: a randomized controlled clinical trial Web-based collaborative care intervention to manage cancer-related symptoms in the palliative care setting Validation of the cancer care monitor items for physical symptoms and treatment side effects using expert oncology nurse evaluation The patient care monitor-neutropenia index: development, reliability, and validity of a measure for chemotherapy-induced neutropenia Use of a webbased app to improve breast cancer symptom management and adherence for aromatase inhibitors: a randomized controlled feasibility trial Symptom management implementation of patient reported outcomes in oncology (SIMPRO) THRIVE study protocol: a randomized controlled trial evaluating a web-based app and tailored messages to improve adherence to adjuvant endocrine therapy among women with breast cancer The eSMART study protocol: a randomised controlled trial to evaluate electronic symptom management using the advanced symptom management system (ASyMS) remote technology for patients with cancer The patient remote intervention and symptom management system (PRISMS) -a Telehealth-mediated intervention enabling real-time monitoring of chemotherapy side-effects in patients with haematological malignancies: study protocol for a randomised controlled trial The HOPE trial: helping our patients excel Home telemonitoring for patients with lung cancer (HTPLC) Self-monitoring and reminder texts to increase physical activity after cancer II (SmartPaceII) Electronic patient self-reporting of adverse-events: patient information and aDvice (eRAPID): a randomised controlled trial in systemic cancer treatment Effects of an interactive mHealth innovation for early detection of patient-reported symptom distress with focus on participatory care: protocol for a study based on prospective, randomised, controlled trials in patients with prostate and breast cancer Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study Observer error in grading performance status in cancer patients Performance status score: do patients and their oncologists agree? Wearable activity monitors to assess performance status and predict clinical outcomes in advanced cancer patients Wearable activity monitors in oncology trials: current use of an emerging technology Fitbit usage in patients with breast cancer undergoing chemotherapy Large-scale assessment of a smartwatch to identify atrial fibrillation Implantable devices track cardiac events in cancer patients In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. keywords: cancer; care; monitoring; oncology; outcomes; patients; study; symptom; treatment; trial cache: cord-333808-deifddar.txt plain text: cord-333808-deifddar.txt item: #2364 of 2876 id: cord-333816-cznwzcn9 author: Chung, Michael title: CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) date: 2020-02-04 words: 2677 flesch: 46 summary: Chest CT is a key component of the diagnostic work-up for patients with suspected infection, and our investigation has shown some imaging findings frequently encountered in affected patients. In summary, this work represents an early investigation of chest CT findings in the 2019 novel coronavirus (2019-nCoV), with the intention of creating familiarity with common imaging manifestations of the disease. keywords: chest; disease; lung; ncov; patients cache: cord-333816-cznwzcn9.txt plain text: cord-333816-cznwzcn9.txt item: #2365 of 2876 id: cord-333876-fhxkpbq7 author: Rucker, Janet C. title: Cerebellum—Editorial Regarding Consensus Paper Consensus on Virtual Management of Vestibular Disorders: Urgent Versus Expedited Care. Shaikh et al., doi.org/10.1007/s12311-020—01178-8: The Return of the House Call: Evaluating Acutely Ill Patients with Vertigo in the Era of Virtual Health Care date: 2020-09-02 words: 1637 flesch: 20 summary: For example, the currently recruiting AVERT (Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage) trial is a multicenter, phase II clinical trial comparing standard emergency department care for AVS patients with an algorithm-determined diagnosis based on an automated video-oculographic recording interpretation [15] . Dizziness presentations in U.S. emergency departments Normal head impulse test differentiates acute cerebellar strokes from vestibular neuritis International survey of emergency physicians' priorities for clinical decision rules Disconnect between charted vestibular diagnoses and emergency department management decisions: a cross-sectional analysis from a nationally representative sample Nystagmus assessments documented by emergency physicians in acute dizziness presentations: a target for decision support? Use of BPPV processes in emergency department dizziness presentations: a population-based study Pitfalls in the diagnosis of cerebellar infarction Factors associated with misdiagnosis of acute stroke in young adults Missed diagnosis of stroke in the emergency department: a crosssectional analysis of a large population-based sample HINTS to diagnose stroke in the acute vestibular syndrome: threestep bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging HINTS outperforms ABCD2 to screen for stroke in acute continuous vertigo and dizziness Head impulse test in unilateral vestibular loss: vestibulo-ocular reflex and catch-up saccades Telethrombolysis: stroke consultation by telemedicine Recommendations for the implementation of telemedicine within stroke systems of care: a policy statement from the AVERT Phase II Trial: Acute videooculography for vertigo in emergency rooms for rapid triage Impulsive testing of semicircular-canal function using videooculography Head impulse testing using video-oculography Consensus on virtual management of vestibular disorders: urgent versus expedited care Dizziness and vertigo: the skillfull examination A new diagnostic approach to the adult patient with acute dizziness Questionnaire-based diagnosis of benign paroxysmal positional vertigo Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations keywords: emergency; examination; patients; stroke; vertigo cache: cord-333876-fhxkpbq7.txt plain text: cord-333876-fhxkpbq7.txt item: #2366 of 2876 id: cord-334002-irbpehts author: Silva, Michelle A title: Telehealth treatment engagement with Latinx populations during the COVID-19 pandemic date: 2020-10-08 words: 1426 flesch: 34 summary: Despite the potential for greater access to care for Latinx communities, the consequences of long-standing mistrust, stigma, and an existing ambivalence towards mental health treatment need to be considered. We propose the use of T-HOLA (the word hola means hello in Spanish), an acronym designed to offer practical guidance to providers engaging Latinx patients in telehealth interventions through the application of motivational interviewing skills and consideration of cultural values: (1) orient to Telehealth; (2) engage in T: orient to telehealth An initial step is to provide the patient with an orientation to the telehealth platform. keywords: health; patient; telehealth; use cache: cord-334002-irbpehts.txt plain text: cord-334002-irbpehts.txt item: #2367 of 2876 id: cord-334075-ruqd2c1j author: Der Sarkissian, Samuel title: Response of a tertiary dermatology department to COVID‐19 date: 2020-04-21 words: 658 flesch: 46 summary: A significant rise in case numbers is expected in the coming weeks. We have defined urgent surgical cases as melanoma, and squamous cell carcinoma and other cutaneous tumours in high-risk areas or immunosuppressed patients. keywords: cases; department; dermatology cache: cord-334075-ruqd2c1j.txt plain text: cord-334075-ruqd2c1j.txt item: #2368 of 2876 id: cord-334092-50r3h7jv author: Loungani, Rahul S. title: A care pathway for the cardiovascular complications of COVID-19: Insights from an institutional response date: 2020-05-03 words: 4007 flesch: 24 summary: Our algorithm ( Figure 1 ) recommends evaluation of cardiac biomarkers of all confirmed COVID-19 patients requiring admission to the hospital for prognostication and during any acute decompensation to screen for cardiac dysfunction. It has helped organize our internal discussions around management of cardiovascular complications and provides clear guidance to providers on the frontlines who may be less familiar with the care of cardiovascular patients. keywords: acute; cardiac; cardiovascular; care; covid-19; disease; infection; injury; patients; risk cache: cord-334092-50r3h7jv.txt plain text: cord-334092-50r3h7jv.txt item: #2369 of 2876 id: cord-334188-bggt1i2e author: Solari, Domenico title: The nose lid for the endoscopic endonasal procedures during COVID-19 era: technical note date: 2020-08-11 words: 2607 flesch: 36 summary: Nonetheless, it remains advisable to strictly adhere to COVID-19 protocols and carefully evaluate patients and procedures, in order to ensure safety and eventually limit the contagion. Helmet modification to PPE with 3D printing during the COVID-19 pandemic at Duke University Medical Center: a novel technique SAGES and EAES recommendations for minimally invasive surgery during COVID-19 pandemic Safety recommendations for evaluation and surgery of the head and neck during the COVID-19 pandemic Covid-19 patients and surgery: guidelines and checklist proposal Letter: The Risk of COVID-19 infection during neurosurgical procedures: a review of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) modes of transmission and proposed neurosurgery-specific measures for mitigation Applications of 3D printing technology to address COVID-19 related supply shortages COVID-19 pandemic: effects and evidence-based recommendations for otolaryngology and head and neck surgery practice High risk of COVID-19 infection for head and neck surgeons Endonasal neurosurgery during the COVID-19 pandemic: the Singapore perspective Sichuan University Covid-ERG (2020) Epidemiology, treatment, and epidemic prevention and control of the coronavirus disease 2019: a review Letter: precautions for endoscopic transnasal skull base surgery during the COVID-19 pandemic keywords: covid-19; lid; mask; nose; pandemic; patients; surgery cache: cord-334188-bggt1i2e.txt plain text: cord-334188-bggt1i2e.txt item: #2370 of 2876 id: cord-334212-3gqzeakb author: Chun, Tristen T. title: Phlegmasia Cerulea Dolens Associated with Acute COVID-19 Pneumonia Despite Supratherapeutic Warfarin Anticoagulation date: 2020-10-19 words: 596 flesch: 40 summary: On hospital day 1 following admission to our tertiary care center, the 6 patient underwent lower extremity venography, placement of a retrievable filter and mechanical 7 thrombectomy using ClotTriever® (Inari Medical) with successful restoration of patency in the 8 left popliteal, femoral and iliac veins (FIGURE 2). A high index of suspicion is required by vascular surgeons in patients presenting with this novel virus. keywords: acute; covid-19; patient cache: cord-334212-3gqzeakb.txt plain text: cord-334212-3gqzeakb.txt item: #2371 of 2876 id: cord-334235-ymsiihwd author: Gray, Belinda title: Patients with Genetic Heart Disease and COVID-19: A Cardiac Society of Australia and New Zealand (CSANZ) Consensus Statement date: 2020-04-30 words: 1182 flesch: 39 summary: • We recommend that Brugada syndrome patients with fever that is unresponsive to paracetamol should seek urgent specialist cardiology advice as they may require more intensive monitoring. However, we have identified areas of consensus among specialists from the Cardiac Society of Australia and New Zealand (CSANZ) Cardiovascular Genetics Diseases Council with regards to managing patients with genetic heart disease in this current COVID-19 pandemic. keywords: covid-19; patients; risk cache: cord-334235-ymsiihwd.txt plain text: cord-334235-ymsiihwd.txt item: #2372 of 2876 id: cord-334324-remrcm2q author: Kunal, Shekhar title: Cardiovascular complications and its impact on outcomes in COVID-19 date: 2020-11-04 words: 3297 flesch: 40 summary: Summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus-Infected pneumonia in Wuhan Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study Cardiac involvement in a patient with Coronavirus Disease 2019 (COVID-19) Myocarditis in a patient with COVID-19: a cause of raised troponin and ECG changes COVID-19 complicated by acute pulmonary embolism and right-sided heart failure Initial ELSO Guidance Document: ECMO for COVID-19 patients with severe cardiopulmonary failure Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography Cardiac and arrhythmic complications in patients with COVID-19 Novel coronavirus 19 (COVID-19) associated sinus node dysfunction: a case series Urgent guidance for navigating and circumventing the QTc-Prolonging and Torsadogenic potential of possible pharmacotherapies for Coronavirus Disease 19 (COVID-19) The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin Assessment of QT Intervals in a case series of patients with Coronavirus Disease 2019 (COVID-19) infection treated with Hydroxychloroquine alone or in combination with Azithromycin in an intensive care unit Risk of QT Interval prolongation associated with use of Hydroxychloroquine with or without concomitant Azithromycin among hospitalized patients testing positive for Coronavirus Disease Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: Limited data exists regarding the involvement of cardiovascular system in COVID-19 patients. keywords: acute; cardiac; coronavirus; covid-19; injury; patients cache: cord-334324-remrcm2q.txt plain text: cord-334324-remrcm2q.txt item: #2373 of 2876 id: cord-334367-w96iqo6q author: Devlin, John W. title: Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults With Coronavirus Disease 2019 date: 2020-06-12 words: 4229 flesch: 28 summary: Although multiple studies demonstrate the salutary impact of Bundle use on ICU patient care, outcomes, and healthcare costs in non-COVID-19 patients (21) (22) (23) (24) , important COVID-19-related issues and barriers may preclude the routine use of the Bundle in this population, particularly at centers experiencing a surge of critically ill adults with COVID-19. Society of Critical Care Medicine and the American Society for Parenteral and Enteral Nutrition Incidence of propofol-related infusion syndrome in critically ill adults: A prospective, multicenter study Early neuromuscular blockade in the acute respiratory distress syndrome Clinical practice guidelines for sustained neuromuscular blockade in the adult critically ill patient Demand for Ventilator Drugs 'Unprecedented Repurposing valproate, enteral clonidine, and phenobarbital for comfort in adult ICU patients: A literature review with practical considerations The Medical Letter on Drugs and Therapeutics: Some Drugs for COVID-19. keywords: adults; bundle; care; covid-19; critical; delirium; icu; pain; patients; sedation; strategies; use cache: cord-334367-w96iqo6q.txt plain text: cord-334367-w96iqo6q.txt item: #2374 of 2876 id: cord-334408-w0yxz7zb author: Rosca, Paola title: Isolating the isolated: Implications of COVID-19 quarantine measures on in-patient detoxification treatment for substance use disorders date: 2020-07-06 words: 2232 flesch: 42 summary: These has been done in Israel, by temporary converting 12 vacant private in-patient beds for persons with alcohol use disorder, to in-patient beds for SUD patients. Staff, and clinicians needed for stabilization of SUD patients are not always available in mental health hospitals, nor are staff always well acquainted with specialized addiction treatment. keywords: health; patients; quarantine; services; staff; treatment cache: cord-334408-w0yxz7zb.txt plain text: cord-334408-w0yxz7zb.txt item: #2375 of 2876 id: cord-334495-7y1la856 author: Agricola, Eustachio title: Heart and Lung Multimodality Imaging in COVID-19 date: 2020-06-24 words: 6796 flesch: 25 summary: As many as 40% hospitalized patients presenting with COVID-19 have pre-existing history of cardiovascular disease and current estimates report a proportion of myocardial injury in COVID-19 patients ranging up to 12%. The use of integrated heart and lung multimodality imaging plays a central role in different clinical settings and is essential in diagnosis, risk stratification and management of COVID-19 patients. keywords: acute; cardiac; chest; cov-2; covid-19; disease; imaging; involvement; lung; lus; patients; respiratory; risk; sars cache: cord-334495-7y1la856.txt plain text: cord-334495-7y1la856.txt item: #2376 of 2876 id: cord-334524-8uqnlpvc author: Johannson, Kerri A. title: Remote Monitoring in Idiopathic Pulmonary Fibrosis: Home Is Where the Bluetooth-enabled Spirometer Is date: 2020-08-01 words: 1531 flesch: 41 summary: Beyond simple spirometry, home monitoring in IPF has extended to include measures of physical activity, symptoms, quality of life, and medication tolerability (4) (5) (6) (7) . In this issue of the Journal, Moor and colleagues (pp. 393-401) build on their previous work with data from a multicenter randomized controlled trial of home monitoring in patients with IPF (8) . keywords: care; home; lung; monitoring; patients cache: cord-334524-8uqnlpvc.txt plain text: cord-334524-8uqnlpvc.txt item: #2377 of 2876 id: cord-334715-902pfxyz author: Sirico, Domenico title: Cardiac imaging in congenital heart disease during the coronavirus disease-2019 pandemic: recommendations from the Working Group on Congenital Heart Disease of the Italian Society of Cardiology date: 2020-06-01 words: 2549 flesch: 32 summary: CT and MR machine gantries, and reporting stations (monitor, mouse and keyboards) should be sanitized after every contact with suspected patients. (2) Scheduled echocardiogram in known CHD patient whose cardiac status has changed from previous ultrasound investigation but is otherwise clinically stable. keywords: cardiac; covid-19; gloves; hands; infection; patients; wash cache: cord-334715-902pfxyz.txt plain text: cord-334715-902pfxyz.txt item: #2378 of 2876 id: cord-334773-yw2qgv13 author: Lisco, Giuseppe title: Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review date: 2020-08-10 words: 7912 flesch: 27 summary: Unfortunately, inconclusive deductions are currently available for considering concomitant medications favourable (as well as detrimental) factors in COVID-19 patients with T2D. Despite some putative mechanisms have been identified and some speculative hypothesis have also been formulated indicating that some anti-diabetes medications may improve clinical course in COVID-19 (pioglitazone, gliflozins, DPP-IV inhibitors, GLP-1RA), further studies are needed to clarify the issue. Considering that pancreatic islets express ACE 2 , glucose impairment in COVID-19 diabetic patients could be attributable to a partial insulin deficiency keywords: cardiovascular; coronavirus; cov-2; covid-19; diabetes; disease; glucose; immune; infection; obesity; patients; prognosis; response; risk; sars; t2d cache: cord-334773-yw2qgv13.txt plain text: cord-334773-yw2qgv13.txt item: #2379 of 2876 id: cord-334790-lav794w0 author: Jin, Huijuan title: Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists date: 2020-04-01 words: 3564 flesch: 46 summary: Therefore, neurologists should be vigilant when seeing COVID-19 infected patients and look for any signs suspicious for intracranial infection, and if possible, MRI of head with and without contrast should be performed. In other patients, their temperature may drop, but their pneumonia actually progressed. keywords: coronavirus; cov-2; covid-19; disease; infection; patients; sars; symptoms; treatment cache: cord-334790-lav794w0.txt plain text: cord-334790-lav794w0.txt item: #2380 of 2876 id: cord-334835-j6u8t8j2 author: Berenguer, Juan title: Characteristics and predictors of death among 4,035 consecutively hospitalized patients with COVID-19 in Spain date: 2020-08-04 words: 1740 flesch: 48 summary: Recent studies with COVID-19 patients indicate that 252 younger hospitalized individuals were more likely to be obese (23) and that obesity is associated 253 with severe pictures (23-25) and increased mortality (14). We aimed to analyse the characteristics and predictors of death in hospitalized patients with COVID-19 in Spain. keywords: age; covid-19; death; mortality; patients cache: cord-334835-j6u8t8j2.txt plain text: cord-334835-j6u8t8j2.txt item: #2381 of 2876 id: cord-334881-x9nxxled author: Di Lorenzo, Giuseppe title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 words: 3254 flesch: 35 summary: key: cord-334881-x9nxxled authors: Di Lorenzo, Giuseppe; Di Trolio, Rossella; Kozlakidis, Zisis; Busto, Giuseppina; Ingenito, Concetta; Buonerba, Luciana; Ferrara, Claudia; Libroia, Annamaria; Ragone, Gianluca; Ioio, Concetta dello; Savastano, Beatrice; Polverino, Mario; De Falco, Ferdinando; Iaccarino, Simona; Leo, Emilio title: COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature date: 2020-05-21 journal: Crit Rev Oncol Hematol DOI: 10.1016/j.critrevonc.2020.102991 sha: doc_id: 334881 cord_uid: x9nxxled BACKGROUND: It is reasonable to think that cancer patients undergoing chemotherapy, targeted therapy or immunotherapy could have a more aggressive course if positive for Coronavirus disease CoV-2 (COVID- 19). Thus, during this COVID-19 crisis, cancer patients are regarded as a highly vulnerable group. keywords: cancer; coronavirus; covid-19; disease; drugs; patients; study; therapy; treatment cache: cord-334881-x9nxxled.txt plain text: cord-334881-x9nxxled.txt item: #2382 of 2876 id: cord-335033-cwhm7v0s author: Vergano, Marco title: Clinical ethics recommendations for the allocation of intensive care treatments in exceptional, resource-limited circumstances: the Italian perspective during the COVID-19 epidemic date: 2020-04-22 words: 1550 flesch: 36 summary: In the worst-case scenario of complete saturation of ICU resources, a first come, first served criterion is not recommended, as it would ultimately result in denying access to ICU care to a large number of potentially curable patients. Moreover, the patients who are affected by the application of new, more stringent criteria of eligibility for ICU admission (and/or their proxies) should be Allocation of ICU resources is a complex and delicate task. keywords: admission; care; icu; patients cache: cord-335033-cwhm7v0s.txt plain text: cord-335033-cwhm7v0s.txt item: #2383 of 2876 id: cord-335078-z7k59k8o author: Burton-Papp, Helmi C. title: Conscious prone positioning during non-invasive ventilation in COVID-19 patients: experience from a single centre date: 2020-07-31 words: 3768 flesch: 38 summary: All NIV and prone patients (N=20) Only NIV (N=13) Age, year* 53.4 ± 8.3 54.6 ± 9.1 51.3 ± 6.8 Male sex, n (%) (55%) (42.9%) (61.5%) Duration of symptoms (days) † 7 (6) 7 (4.25) 9 (6.5) NHS England COVID-19 specific guidance suggests that prone position may be of use in NIV patients to improve ventilation/perfusion mismatch, work of breathing and oxygenation 13 . keywords: covid-19; data; niv; patients; positioning; proning; ventilation cache: cord-335078-z7k59k8o.txt plain text: cord-335078-z7k59k8o.txt item: #2384 of 2876 id: cord-335095-epsi5qq7 author: Feng, Gong title: Clinical Features of COVID-19 Patients in Xiaogan City date: 2020-08-24 words: 2804 flesch: 51 summary: The objectives are to study the clinical features of COVID-19 patients and assess the relationship between the severity of COVID-19, age, and C-reactive protein (CRP) levels. This study documented COVID-19 patients. keywords: age; covid-19; crp; disease; levels; patients; severity; xiaogan cache: cord-335095-epsi5qq7.txt plain text: cord-335095-epsi5qq7.txt item: #2385 of 2876 id: cord-335140-njg0ln33 author: Freeman, Ciara L title: Covid‐19 and Myeloma: what are the implications for now and in the future? date: 2020-05-19 words: 3365 flesch: 36 summary: We also need to consider that the way we deliver care to myeloma patients may forever be changed as a result of the outbreak of COVID-19. For myeloma patients, who are frequently elderly, may have co-morbidities, variable frailty or mobility issues this is probably one of the most welcome strategies that has been employed -and perhaps will be one of the most positive changes to emerge from this pandemic (7) (8) (9) . keywords: article; care; copyright; covid-19; myeloma; patients; rights; risk; treatment cache: cord-335140-njg0ln33.txt plain text: cord-335140-njg0ln33.txt item: #2386 of 2876 id: cord-335141-ag3j8obh author: Higgins, G.C. title: FFP3 reusable respirators for COVID-19; adequate and suitable in the healthcare setting date: 2020-06-30 words: 22066 flesch: 48 summary: When asked Would you think other patients would like to have a similar AR leaflet before surgery and Would you like to see further AR leaflets to be developed in the future? In addition to those directly working in the respiratory, infectious, cardiology, nephrology, psychology, and ICU departments and COVID-19 patients, all members of the general population may encounter the new coronavirus. keywords: article; authors; care; clinic; covid-19; data; face; flap; free; hand; health; hospital; information; lymphedema; lymphorrhea; nhs; pandemic; patients; plastic; plastic surgery; practice; publication; reconstruction; risk; scar; service; skin; social; staff; study; surgeons; surgery; therapy; time; trainees; training; trauma; treatment; use; wound cache: cord-335141-ag3j8obh.txt plain text: cord-335141-ag3j8obh.txt item: #2387 of 2876 id: cord-335168-3ofarutr author: Bhat, Yasmeen Jabeen title: Impact of COVID-19 Pandemic on Dermatologists and Dermatology Practice date: 2020-05-10 words: 3364 flesch: 34 summary: Indian Council of Medical Research Potential of chloroquine and hydroxychloroquine to treat COVID-19 causes fears of shortages among people with systemic lupus erythematosus A case of exacerbation of psoriasis after oseltamivir and hydroxychloroquine in a patient with COVID-19: Will cases of psoriasis increase after COVID-19 pandemic? The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro Dermatology Residents and the care of COVID-19 Patients Self medications and poor compliance of dermatology patients in addition to lack of proper treatment protocols and monitoring are a serious concern in the present scenario. keywords: covid-19; dermatologists; dermatology; india; infection; medical; pandemic; patients; risk; use cache: cord-335168-3ofarutr.txt plain text: cord-335168-3ofarutr.txt item: #2388 of 2876 id: cord-335198-qp964238 author: Kotsimbos, T. title: Pandemic Treatments on Trial: The bigger picture date: 2020-08-03 words: 2728 flesch: 35 summary: Negotiating the deep chasm between frameworks is a key challenge for treating clinicians so that we don't get lost in a multitude of poorly controlled studies but leap towards a hierarchy of larger clinical trials arranged according to likelihood of success based on early but uncertain signals in smaller numbers of patients. From early, uncontrolled results that reported a clinical improvement in 68% of 53 analyzable patients (10) through to a negative RCT study result involving 236 patients which was stopped early due to reduced case numbers in China resulting in a trial with reduced power to detect any smaller clinically significant benefit with any certainty (11) to further preliminary reports of potentially positive results in larger trials sponsored by the remdisivir patent holder (12) . keywords: covid-19; pandemic; patients; potential; therapies; treatment; trial cache: cord-335198-qp964238.txt plain text: cord-335198-qp964238.txt item: #2389 of 2876 id: cord-335265-kuc3v5m9 author: Elghazawy, Hagar title: Implementation of breast cancer continuum of care in low- and middle-income countries during the COVID-19 pandemic date: 2020-07-27 words: 7108 flesch: 32 summary: Characteristics of COVID-19 patients dying in Italy: report based on available data on Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Call for ensuring cancer care continuity during COVID-19 pandemic Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study Case fatality rate of cancer patients with COVID-19 in a New York hospital system COVID-19 rapid guideline: delivery of systemic anticancer treatments guidance Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. Coronavirus disease (COVID-19) situation reports Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak New country classifications by income level Global Health Initiatives of the International Oncology Community Radiation therapy availability in Africa and Latin America: two models of low and middle income countries COVID-19 and its ramifications for cancer patients in low-resource settings: Ghana as a case study Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Breast cancer-thinking globally Drivers of advanced stage at breast cancer diagnosis in the multicountry African breast cancer -disparities in outcomes (ABCDO) study ASCO resource-stratified guidelines: methods and opportunities Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan COVID-19 and cancer: lessons from a pooled meta-analysis Global Cancer Observatory: Cancer Today. keywords: breast; cancer; care; clinical; covid-19; disease; infection; lmic; oncology; pandemic; patients; radiotherapy; risk; surgery; therapy; treatment cache: cord-335265-kuc3v5m9.txt plain text: cord-335265-kuc3v5m9.txt item: #2390 of 2876 id: cord-335312-yp73z008 author: Bergsland, Emily K. title: North American Neuroendocrine Tumor Society Guide for Neuroendocrine Tumor Patient Health Care Providers During COVID-19 date: 2020-05-19 words: 3412 flesch: 38 summary: Hospital resources are all routed to COVID-19 patients, there is no ventilator or ICU capacity, or operating room supplies are exhausted. If there is a pressing need for treatment, one might consider starting with a lower outpatient dose, both to avoid the need to do dosimetry (which would require additional visits to the hospital) and to avoid taking up an inpatient bed (radiation safety rooms at many centers may be located on wards designated for COVID-19 patients). keywords: care; covid-19; nets; patients; risk; therapy; treatment; tumor cache: cord-335312-yp73z008.txt plain text: cord-335312-yp73z008.txt item: #2391 of 2876 id: cord-335338-wzxjn5ip author: Wei, Lan title: Pathology of the thyroid in severe acute respiratory syndrome() date: 2006-09-25 words: 3538 flesch: 41 summary: Influences of thyrocalcitonin, parathyroid hormone, neutral phosphate and vitamin D3 Pathological changes and pathogenesis of fatal severe acute respiratory syndrome Immunopathogenesis of coronavirus infections: implications for SARS Pathogenesis of severe acute respiratory syndrome How the SARS coronavirus causes disease: host or organism? SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways However, it is possible that there is an alternative explanation for osteonecrosis related to loss of calcitonin-producing cells in SARS thyroid glands. keywords: acute; apoptosis; calcitonin; cells; patients; sars; syndrome; thyroid cache: cord-335338-wzxjn5ip.txt plain text: cord-335338-wzxjn5ip.txt item: #2392 of 2876 id: cord-335351-8hdok02n author: Hashmi, Muhammad Daniyal title: Assessing the need for transfer to the intensive care unit for Coronavirus-19 disease: Epidemiology and risk factors date: 2020-10-27 words: 3792 flesch: 52 summary: Co-morbid illnesses are not associated with the risk for ICU transfer while two initial lab values (ALC <0.8 10 3 /ml and ferritin >1000 ng/mL ) identify those at higher risk for ICU admission. Neither baseline clinical factors nor the CURB-65 score perform well as screening tests to categorize these subjects as likely to progress to ICU care. keywords: care; covid-19; icu; need; patients; risk; score; transfer cache: cord-335351-8hdok02n.txt plain text: cord-335351-8hdok02n.txt item: #2393 of 2876 id: cord-335382-fk4um9nw author: Farver, Carol F. title: Molecular Basis of Pulmonary Disease date: 2012-08-10 words: 32359 flesch: 38 summary: In hyperoxia-induced cell death, hyperoxia may induce the expression of angiopoietin 2 (Ang2) in lung epithelial cells. Annual report to the nation on the status of cancer Pathology and Genetics of Tumours of the Lung, Pleura AJCC Cancer Staging Manual varying), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released Diagnosis and management of lung cancer executive summary: ACCP evidence-based clinical practice guidelines Genetics of preneoplasia: Lessons from lung cancer Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH Lung cancer preneoplasia Characterizing the cancer genome in lung adenocarcinoma Focus on lung cancer New molecularly targeted therapies for lung cancer High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints Genetic and molecular alterations Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma Hereditary cancers disclose a class of cancer genes Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers Molecular oncogenesis of lung cancer Molecular genetics of lung cancer The P16/cyclin D1/ keywords: airways; alveolar; asthma; carcinoids; cases; cause; cell lung; cells; changes; chest; chronic; disease; epithelium; factor; features; fibrosis; figure; form; gene; human; infections; inflammatory; injury; lesions; loss; lung; lung cancer; lung disease; macrophages; mechanisms; mutations; organisms; pathogenesis; pathology; patients; pneumonia; present; proliferation; protein; pulmonary; response; result; role; sarcoidosis; studies; surfactant; tissue; tumor; type cache: cord-335382-fk4um9nw.txt plain text: cord-335382-fk4um9nw.txt item: #2394 of 2876 id: cord-335465-sckfkciz author: Gupta, Rishi K. title: Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study date: 2020-09-25 words: 5056 flesch: 27 summary: The most discriminating univariable predictor is admission oxygen saturation (SpO2) on room air for deterioration models and patient age for mortality models. Importantly, prognostic models may have additional value in patient stratification for emerging drug therapies [6, 7] . keywords: covid-19; deterioration; hospital; models; mortality; patients; prediction; predictors; prognostic; risk; study cache: cord-335465-sckfkciz.txt plain text: cord-335465-sckfkciz.txt item: #2395 of 2876 id: cord-335540-lahu5dno author: Granata, Tiziana title: Did the COVID‐19 pandemic silence the needs of people with epilepsy? date: 2020-09-19 words: 2442 flesch: 45 summary: We describe the impact of the pandemic on epilepsy care in three tertiary epilepsy centres from Spain and Italy, the most affected European countries. The activities related to epilepsy care were reduced to less than 10% and were deprioritized. keywords: care; centres; covid-19; eeg; epilepsy; pandemic; patients cache: cord-335540-lahu5dno.txt plain text: cord-335540-lahu5dno.txt item: #2396 of 2876 id: cord-335576-b34nc3ay author: Tsai, Andrew title: Impact of tocilizumab administration on mortality in severe COVID-19 date: 2020-11-05 words: 2921 flesch: 38 summary: A clinical trial evaluating sarilumab in COVID-19 patients was discontinued after failing to meet its primary and key secondary endpoints, and instead revealed negative trends in clinical status of patients who were not mechanically ventilated as baseline 24 . The TOCIVID-19 phase 2 trial Roche rheumatoid arthritis drug fails to help COVID-19 patients in Italian study COVID-19) Treatment Guidelines keywords: analysis; covid-19; cytokine; data; patients; propensity; study; tocilizumab cache: cord-335576-b34nc3ay.txt plain text: cord-335576-b34nc3ay.txt item: #2397 of 2876 id: cord-335593-cjb0daps author: Romagnolo, Alberto title: Neurological comorbidity and severity of COVID-19 date: 2020-08-04 words: 3436 flesch: 33 summary: A scoping review on the occurrence of neurological diseases in COVID-19 patients reported a prevalence of about 8% [12] . Nevertheless, this review highlighted the methodological heterogeneity in the reviewed papers, which limit a reliable estimation of prevalence of neurological diseases in COVID-19 patients, as well as their association with the infection severity. keywords: association; comorbidities; covid-19; data; diseases; infection; patients cache: cord-335593-cjb0daps.txt plain text: cord-335593-cjb0daps.txt item: #2398 of 2876 id: cord-335597-anrzcsrt author: None title: 44. Jahrestagung der Österreichischen Gesellschaft für Pneumologie date: 2020-10-26 words: 14654 flesch: 44 summary: Methods: We performed single cell RNA sequencing on pulmonary arteries isolated from donors and pulmonary hypertension patients. Arteries in pulmonary hypertension patients displayed altered composition of EC population characterized by the diminished presence of one cell cluster. keywords: age; analysis; asthma; background; cell; cohort; conclusions; copd; covid-19; data; disease; eine; exercise; function; inflammatory; lung; mean; median; methods; mit; months; mortality; p =; pain; patients; pulmonary; results; score; study; survival; symptoms; therapy; treatment; years cache: cord-335597-anrzcsrt.txt plain text: cord-335597-anrzcsrt.txt item: #2399 of 2876 id: cord-335680-wsczl68g author: Brown, Charles A. title: Myocarditis and idiopathic dilated cardiomyopathy date: 1995-09-30 words: 3393 flesch: 32 summary: In patients with clinical heart failure and myocarditis, nonspecific findings such as left ventricular systolic dysfunction, enlarged left ventricular cavity size, and increased wall thickness and wall motion abnormalities may be seen on echocardiography. key: cord-335680-wsczl68g authors: Brown, Charles A.; O'Connell, John B. title: Myocarditis and idiopathic dilated cardiomyopathy date: 1995-09-30 journal: The American Journal of Medicine DOI: 10.1016/s0002-9343(99)80164-8 sha: doc_id: 335680 cord_uid: wsczl68g Abstract Idiopathic dilated cardiomyopathy (IDC) accounts for 25% of cases of heart failure in the United States. keywords: biopsy; disease; failure; heart; idc; myocarditis; patients; ventricular cache: cord-335680-wsczl68g.txt plain text: cord-335680-wsczl68g.txt item: #2400 of 2876 id: cord-335719-tnimrff9 author: Wang, Chia-shi title: eHealth in kidney care date: 2020-04-01 words: 1473 flesch: 33 summary: Multiple other studies have reported high participant satisfaction with kidney eHealth interventions for a variety of reasons, including ease of use, low burden and increased frequency and quality of interactions with health-care staff 6 . A 2019 Cochrane review concluded that overall, the evidence for eHealth interventions is of low quality and insufficient to guide clinical practice in kidney disease 6 . keywords: care; disease; ehealth; kidney; patients cache: cord-335719-tnimrff9.txt plain text: cord-335719-tnimrff9.txt item: #2401 of 2876 id: cord-335744-haj5a7tf author: Chibbaro, Salvatore title: How SARS-CoV-2 is forcing us to reconsider and reorganize our daily neurosurgical practice date: 2020-05-13 words: 1699 flesch: 30 summary: One theatre was dedicated to urgent COVID-19 patients, one to urgent non COVID-19 confirmed patients (24/7), and one to 48-hour-deferrable patients (a.k.a. In fact, the geographical characteristics of our region and the strong bond with other units allowed us to transfer critical patients a few kilometers away to Germany, a country with more ICU beds available, and to other centers in our region where elective neurosurgical practice had not been disrupted as much as in Strasbourg. keywords: covid-19; crisis; pandemic; patients; practice cache: cord-335744-haj5a7tf.txt plain text: cord-335744-haj5a7tf.txt item: #2402 of 2876 id: cord-335759-io18c6z0 author: Sprik, Petra title: Feasibility and acceptability of a telephone-based chaplaincy intervention in a large, outpatient oncology center date: 2020-07-04 words: 5524 flesch: 45 summary: After having experienced the telephone-based chaplaincy intervention, survey participants were asked how they would prefer to receive chaplain interventions from a list of options available for multi-select. Vision VISN 20 Annual Report The feasibility and acceptability of a chaplain-led intervention for caregivers of seriously ill patients: a caregiver outlook pilot study Feasibility and acceptability of a telephone-based chaplaincy intervention to decrease parental spiritual struggle The impact of lay pastoral telecare on the spiritual well-being of church attenders Using patientreported religious/spiritual concerns to identify patients who accept chaplain interventions in an outpatient oncology setting A qualitative study of patient and family perceptions of chaplain presence during posttrauma care What do I do? keywords: acceptability; care; chaplain; intervention; patients; phone; survey; telephone cache: cord-335759-io18c6z0.txt plain text: cord-335759-io18c6z0.txt item: #2403 of 2876 id: cord-335795-hdko0zdw author: Wamsley, Christine E title: Trends and Challenges of Telehealth in an Academic Institution: The Unforeseen Benefits of the COVID-19 Global Pandemic date: 2020-07-22 words: 5008 flesch: 44 summary: The majority of telehealth patients have been between 30 and 79 years old. distribution such that elderly populations comprised a greater proportion of telehealth patients as time passed (ages 60-79 years, Figure 3 ). keywords: care; covid-19; pandemic; patient; person; plastic; state; surgery; telehealth; telemedicine; utsw; visits cache: cord-335795-hdko0zdw.txt plain text: cord-335795-hdko0zdw.txt item: #2404 of 2876 id: cord-335802-1kiqfy68 author: Azoulay, Elie title: Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset date: 2020-08-11 words: 3519 flesch: 43 summary: In the earliest descriptions of COVID-19 patients hospitalised in Wuhan, China, time from viral symptom onset to dyspnoea was 5 days and time to hospital admission was 7 days Interventions that are currently used in COVID-19 patients might impact different clinical endpoints according to time since viral symptom onset. keywords: admission; covid-19; icu; mortality; onset; patients; symptom; time cache: cord-335802-1kiqfy68.txt plain text: cord-335802-1kiqfy68.txt item: #2405 of 2876 id: cord-335892-hwahcec5 author: Marshall, Elena title: Prevalence of hydroxychloroquine retinopathy using 2018 Royal College of Ophthalmologists diagnostic criteria date: 2020-06-25 words: 3010 flesch: 41 summary: Hydroxychloroquine toxicity was identified as either anatomical abnormality (on SD-OCT or fundus autofluorescence (FAF)) or ring-like or partial ring-like scotoma on central 10-2 visual field assessment. All images and field tests were assessed for signs of hydroxychloroquine toxicity and for other pathology. keywords: field; hydroxychloroquine; patients; retinopathy; test; toxicity; years cache: cord-335892-hwahcec5.txt plain text: cord-335892-hwahcec5.txt item: #2406 of 2876 id: cord-335916-fh28qrt7 author: Liu, Cuiwei title: COVID-19 in cancer patients: risk, clinical features, and management date: 2020-08-15 words: 3945 flesch: 33 summary: Given that cancer patients without COVID-19 also have a high risk of these complications, attributing these symptoms in COVID-19 cancer patients solely to underlying cancer is difficult. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72314 cases from the Chinese center for disease control and prevention Clinical characteristics of 2019 novel coronavirus infection in China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan Patients with cancer appear more vulnerable to SARS-COV-2: a multicenter study during the COVID-19 outbreak COVID-19 and cancer: what we know so far Nosocomial infections in patients with cancer Selective depletion of regulatory T cell subsets by docetaxel treatment in patients with nonsmall cell lung cancer Features of postoperative immune suppression are reversible with interferon gamma and independent of interleukin-6 pathways Myeloid suppressor cells in cancer and autoimmunity Case fatality rate of cancer patients with COVID-19 in a New York hospital system Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: a multicentre, retrospective, cohort study COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis Outcome of cancer patients infected with COVID-19, including toxicity of cancer treatments COVID-19 in breast cancer patients: a cohort at the institute curie hospitals in the Paris area Clinical characteristics and outcomes of cancer patients With COVID-19 Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Pathological findings of COVID-19 associated with acute respiratory distress syndrome Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Clinical features of 69 cases with coronavirus disease 2019 in Wuhan, China Review of the 2019 novel coronavirus (COVID-19) based on current evidence Relationships among lymphocyte subsets, cytokines, and the pulmonary inflammation Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Compassionate use of remdesivir for patients with severe covid-19 Therapeutic management of patients with COVID-19: a systematic review Dexamethasone in hospitalized patients with Covid-19 -preliminary report Potential effect of blood purification therapy in reducing cytokine storm as a late complication of critically ill COVID-19 Cytokine storm drugs move from CAR T to COVID-19 Preventing cytokine storm syndrome in COVID-19 using α-1 adrenergic receptor antagonists Seeking and destroying the evils from the inside-translating cancer immunity to fight COVID-19 Cytokine storm and immunomodulatory therapy in COVID-19: role of chloroquine and anti-IL-6 monoclonal antibodies Should we stimulate or suppress immune responses in COVID-19? keywords: cancer; covid-19; patients; risk; sars; study; therapy; treatment cache: cord-335916-fh28qrt7.txt plain text: cord-335916-fh28qrt7.txt item: #2407 of 2876 id: cord-335918-uc225mhn author: None title: COVID-19 Guidance for Triage of Operations for Thoracic Malignancies: A Consensus Statement from Thoracic Surgery Outcomes Research Network date: 2020-04-09 words: 1487 flesch: 33 summary: COVID-19: towards controlling of a pandemic Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Clinical Characteristics of Coronavirus Disease 2019 in China Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State Minimise nosocomial spread of 2019-nCoV when treating acute respiratory failure Effects of Delayed Surgical Resection on Short-Term and Long-Term Outcomes in Clinical Stage I Non-Small Cell Lung Cancer Defining the Ideal Time Interval Between Planned Induction Therapy and Surgery for Stage IIIA Non-Small Cell Lung Cancer Delay in diagnostic workup and treatment of esophageal cancer Does the timing of esophagectomy after chemoradiation affect outcome? Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China A systematic review and meta-analysis of stereotactic body radiation therapy for colorectal pulmonary metastases Lobectomy versus stereotactic body radiotherapy in healthy patients with stage I lung cancer Survival of Primary SBRT Compared to Surgery for Operable Stage I/II Non-Small Cell Lung Cancer Surveillance versus esophagectomy in esophageal cancer patients with a clinical complete response after induction chemoradiation Outcome of delayed versus timely esophagectomy after chemoradiation for esophageal adenocarcinoma Therefore, cancer patients and the oncology teams that treat them are likely to face difficult decisions between suboptimal management strategies. keywords: cancer; covid-19; patients; surgery cache: cord-335918-uc225mhn.txt plain text: cord-335918-uc225mhn.txt item: #2408 of 2876 id: cord-335975-m6lkrehi author: None title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: 89523 flesch: 50 summary: The aim of this study was to compare the outcome of ICU patients having received carbapenems to those having received a carbapenem-sparing agent (CSA). Conclusion: Severe hypoxemia, independently from ARDS, worsens the prognosis of ICU patients. keywords: acute; admission; age; aim; analysis; antibiotic; ards patients; blood; brain; cardiac; care; cases; characteristics; children; clinical; conclusion; criteria; data; days; death; diagnosis; disease; drug; duration; factors; failure; fig; group; high; hospital; icu; icu admission; icu mortality; icu patients; impact; incidence; increase; infection; intensive; introduction; intubation; january; length; level; low; management; mean; median; medical; methods; min; mortality; n =; niv; non; outcome; p =; patients; period; pneumonia; post; pressure; prognosis; rate; respiratory; results; resuscitation; risk; score; sepsis; septic; severity; shock; shock patients; stay; studies; study; study period; therapy; time; treatment; unit; use; vap; ventilation; volume; vs.; years cache: cord-335975-m6lkrehi.txt plain text: cord-335975-m6lkrehi.txt item: #2409 of 2876 id: cord-335977-f00758o2 author: Martin-Loeches, I. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 words: 4307 flesch: 35 summary: key: cord-335977-f00758o2 authors: Martin-Loeches, I.; Lisboa, T.; Rhodes, A.; Moreno, R. P.; Silva, E.; Sprung, C.; Chiche, J. D.; Barahona, D.; Villabon, M.; Balasini, C.; Pearse, R. M.; Matos, R.; Rello, J. title: Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection date: 2010-11-24 journal: Intensive Care Med DOI: 10.1007/s00134-010-2078-z sha: doc_id: 335977 cord_uid: f00758o2 INTRODUCTION: The main objective of this study is therefore to assess the effect on survival of early corticosteroid therapy compared with those who did not receive corticosteroids or received them subsequently as rescue therapy, in a cohort of patients hospitalized with severe presentation of pandemic (H1N1)v influenza A infection in the ICU. keywords: acute; admission; corticosteroid; hospital; icu; infection; influenza; pandemic; patients; pneumonia; therapy; use cache: cord-335977-f00758o2.txt plain text: cord-335977-f00758o2.txt item: #2410 of 2876 id: cord-336000-v88bq4bx author: Barco, Stefano title: Enoxaparin for primary thromboprophylaxis in ambulatory patients with coronavirus disease-2019 (the OVID study): a structured summary of a study protocol for a randomized controlled trial date: 2020-09-09 words: 20408 flesch: 38 summary: OVID may increase the level of safety compared to standard of care for study patients because frequent telephone visits are planned (Day 3, 7, 14, 30, 90) . Source data must be available at the site to document the existence of the study participants and substantiate the integrity of study data collected. keywords: acute; analysis; anti; bleeding; center; covid-19; covid-19 patients; data; days; dose; enoxaparin; events; hospitalization; information; investigator; medical; outcome; patients; risk; study; study center; test; thromboprophylaxis; treatment; trial; use; vte cache: cord-336000-v88bq4bx.txt plain text: cord-336000-v88bq4bx.txt item: #2411 of 2876 id: cord-336053-cjq7szcn author: Mottola, Filiberto Fausto title: Cardiovascular System in COVID-19: Simply a Viewer or a Leading Actor? date: 2020-08-27 words: 5641 flesch: 37 summary: Patients: Awareness of an Increased Prevalence Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Sanchis-Gomar, F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19) Clinical features of patients infected with 2019 novel coronavirus in Association of Coronavirus Disease 2019 (COVID-19) with Myocardial Injury and Mortality SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus The Variety of Cardiovascular Presentations of COVID-19 Coinvolgimento cardiaco in un paziente con malattia coronavirus 2019 (COVID-19) Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems during the COVID-19 Pandemic Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: Results from 8 years of autopsies in 34 892 subjects Seasonal Influenza Infections and Cardiovascular Disease Mortality COVID-19 and the cardiovascular system Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study SARS-CoV-2: A potential novel etiology of fulminant myocarditis Characteristics and Outcomes of Recipients of Heart Transplant with Coronavirus Disease European Heart Rhythm Association (EHRA) consensus document on management of arrhythmias and cardiac electronic devices in the critically ill and post-surgery patient, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin American Heart Rhythm Society (LAHRS) Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy Systemic inflammation and arrhythmic risk: Lessons from rheumatoid arthritis Cardioimmunology of arrhythmias: The role of autoimmune and inflammatory cardiac channelopathies Cardiotoxicity of antimalarial drugs Drug-induced ventricular tachycardia Heart conduction disorders in long-term treatment with chloroquine. While ECG monitoring is always available for COVID-19 patients admitted to ICU, in patients hospitalized in non-intensive rooms, clinicians should monitor QT-intervals according to the risk factors. keywords: acute; cardiac; coronavirus; covid-19; damage; disease; heart; increase; infection; patients; risk; sars cache: cord-336053-cjq7szcn.txt plain text: cord-336053-cjq7szcn.txt item: #2412 of 2876 id: cord-336194-5v395xae author: Darafsheh, Arash title: Mitigating disruptions, and scalability of radiation oncology physics work during the COVID‐19 pandemic date: 2020-05-20 words: 3045 flesch: 40 summary: : scope of practice for clinical medical physics A special report of current state of the medical physicist workforce -results of the 2012 ASTRO Comprehensive Workforce Study A program to train medical physicists for direct patient care responsibilities The solo practice of medical physics in radiation oncology Clinical medical physicists play a vital role in ensuring safe and effective delivery of radiotherapy in a cancer clinic. keywords: cancer; covid-19; medical; oncology; pandemic; patients; physics; radiation; radiotherapy; team cache: cord-336194-5v395xae.txt plain text: cord-336194-5v395xae.txt item: #2413 of 2876 id: cord-336201-fl606l3b author: Daryabor, Gholamreza title: The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System date: 2020-07-22 words: 13880 flesch: 25 summary: The endocrine part is made of different cell types, including α, β, δ, and ε cells that secrete glucagon, insulin, somatostatin, and ghrelin hormones, respectively. A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2 Novel clearance mechanisms of platelets Flow cytometric analysis of platelets type 2 diabetes mellitus reveals 'angry' platelets Platelet activity and hypercoagulation in type 2 diabetes Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus Increased levels of soluble adhesion molecules in type 2 (non-insulin dependent) diabetes mellitus are independent of glycaemic control Molecular mechanisms underpinning microparticle-mediated cellular injury in cardiovascular complications associated with diabetes Association between mean platelet volume in the pathogenesis of type 2 diabetes mellitus and diabetic macrovascular complications in Japanese patients Increased erythrocyte-and platelet-derived microvesicles in newly diagnosed type 2 diabetes mellitus Type 2 diabetes and cardiovascular disease: have all risk factors the same strength? Advanced glycation end products induce a prothrombotic phenotype in mice via interaction with platelet CD36 Central role of the P2Y12 receptor in platelet activation Long non-coding RNA metallothionein 1 pseudogene 3 promotes p2y12 expression by sponging miR-126 to activate platelet in diabetic animal model Introduction to the human gut microbiota Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection Faecalibacterium prausnitzii-derived microbial anti-inflammatory molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression Considering gut microbiota in treatment of type 2 diabetes mellitus Metformin effect on gut microbiota: insights for HIV-related inflammation The bacterium Akkermansia muciniphila: a sentinel for gut permeability and its relevance to HIV-related inflammation High glucose decreases intracellular glutathione concentrations and upregulates inducible nitric oxide synthase gene expression in intestinal epithelial cells The role of iron in diabetes and its complications Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKCalpha-dependent manner Betacell deficit and increased beta-cell apoptosis in humans with type 2 diabetes Fatty acid-induced lipotoxicity in pancreatic beta-cells during development of type 2 diabetes Mesenchymal stem cell therapy in type 2 diabetes mellitus Establishment of insulin-producing cells from human embryonic stem cells underhypoxic condition for cell based therapy Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction A simple method for the generation of insulin producing cells from bone marrow mesenchymal stem cells Secretagogin affects insulin secretion in pancreatic beta-cells by regulating actin dynamics and focal adhesion Secretagogin regulates insulin signaling by direct insulin binding. keywords: cells; diabetes; diabetes mellitus; disease; dm patients; dysfunction; endothelial; et al; expression; glucose; human; immune; individuals; infections; inflammation; insulin; levels; macrophages; mellitus; mice; patients; resistance; risk; role; t2 dm; type cache: cord-336201-fl606l3b.txt plain text: cord-336201-fl606l3b.txt item: #2414 of 2876 id: cord-336252-e92omqyr author: Chen, Tracy Yixin title: COVID‐19 pneumonia in kidney transplant recipients: Focus on immunosuppression management date: 2020-07-06 words: 1884 flesch: 26 summary: Initial report from the US epicenter A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia Covid-19 and kidney transplantation The COVID-19 Pandemic in the US Effectiveness and safety of two different antithymocyte globulins used in induction therapy in kidney transplant recipients: a single-center experience Polyclonal anti T-lymphocyte antibody therapy monitoring in kidney transplant recipients: comparison of CD3+ T cell and total lymphocyte counts Monitoring of CD3(+) T-cell count in patients receiving antithymocyte globulin induction after cadaveric renal transplantation Effect of rabbit antithymocyte globulin on acute and chronic active antibody-mediated rejection after kidney transplantation Direct antiviral mechanisms of interferon-gamma Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic Cyclosporin A and tacrolimus reduce T-cell polyfunctionality but not interferon-γ responses directed at cytomegalovirus Pathogen-specific T cell polyfunctionality is a correlate of T cell efficacy and immune protection T cell exhaustion during persistent viral infections Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) Fighting COVID-19 exhausts T cells Dysregulation of Immune Response in Patients With Coronavirus Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome Immunosuppression for hyperinflammation in COVID-19: a double-edged sword? keywords: covid-19; disease; kidney; patients; pneumonia; transplant cache: cord-336252-e92omqyr.txt plain text: cord-336252-e92omqyr.txt item: #2415 of 2876 id: cord-336258-dxps48bo author: Lee, Anne W.M. title: Advocacy to provide good quality oncology services during the COVID-19 pandemic – Actions at 3-Levels date: 2020-05-08 words: 2150 flesch: 44 summary: Not only is the cumulated number of COVID-19 patients substantially lower in other provinces, the drop in new cases occurred much earlier (Fig. 1B) . diagnostic PCR test is extensively provided to screen all high-risk cohorts and patients requiring admission As a designated hospital responsible for convalescent care of COVID-19 patients and screening of foreign citizens/visitors, special measures are implemented to ensure safety for all staffs and patients, while continuing to provide essential clinical services as far as we can. keywords: covid-19; hospital; patients; services; staffs; treatment cache: cord-336258-dxps48bo.txt plain text: cord-336258-dxps48bo.txt item: #2416 of 2876 id: cord-336268-azgswke8 author: Porcel-Vazquez, Juan A. title: Usefulness of PCR Screening in the Initial Triage of Trauma Patients During COVID-19 Pandemic date: 2020-07-13 words: 3452 flesch: 43 summary: Initial triage to perform quantitative reverse transcription polymerase chain reaction (RT-qPCR) based on symptoms of respiratory disease and chest x-ray and/or based on epidemiological criteria in the emergency department (ED) may be not enough to avoid nosocomial infection or unprotected hospitalization and surgery for health care workers due to the significant incidence of asymptomatic COVID-19 patients. Unfortunately, a high proportion of COVID-19 patients (56%) present no or mild symptoms, 8 thus hindering their management. keywords: covid-19; health; infection; patients; period; symptoms cache: cord-336268-azgswke8.txt plain text: cord-336268-azgswke8.txt item: #2417 of 2876 id: cord-336306-hvy9ukhh author: Zhu, Jieyun title: Clinical characteristics of 3,062 COVID‐19 patients: a meta‐analysis date: 2020-04-15 words: 2119 flesch: 50 summary: We also performed a manual search of the references lists of included studies to avoid omitting any eligible study. This study has several strengths, including its large sample size and high quality of included studies. keywords: analysis; covid-19; meta; patients; studies; study cache: cord-336306-hvy9ukhh.txt plain text: cord-336306-hvy9ukhh.txt item: #2418 of 2876 id: cord-336314-xf6zvvl8 author: Hu, Lijuan title: Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia date: 2020-05-26 words: 898 flesch: 42 summary: The initial manifestation of severe COVID-19 pneumonia patients was hypoxemic respiratory failure, accompanied by rapid increased reactive heart rate and susceptibility to supraventricular arrhythmia Taken together, heart rate monitoring of severe COVID-19 pneumonia patients should be strengthened during treatment, and catecholamines should be appropriately applied when necessary. keywords: bradycardia; patients; sinus cache: cord-336314-xf6zvvl8.txt plain text: cord-336314-xf6zvvl8.txt item: #2419 of 2876 id: cord-336336-f01khqqr author: Singh, Rajat title: Therapeutic Strategy for Coronavirus Disease 2019 in Patients on Durable Left Ventricular Assist Device Support date: 2020-05-13 words: 350 flesch: 23 summary: In conclusion, management of advanced heart failure patients on durable mechanical circulatory support with COVID-19 infection is challenging given the presence of complex comorbidities and unique physiology of this patient population. (1) The author raised several important questions regarding the complexity in management of LVAD patients with COVID-19 infection. keywords: patients cache: cord-336336-f01khqqr.txt plain text: cord-336336-f01khqqr.txt item: #2420 of 2876 id: cord-336368-sudi4mdx author: Thiruvenkatarajan, Venkatesan title: High-flow nasal cannula versus standard oxygen therapy assisting sedation during endoscopic retrograde cholangiopancreatography in high risk cases (OTHER): study protocol of a randomised multicentric trial date: 2020-05-29 words: 4230 flesch: 41 summary: A prospective assessment of sedation-related adverse events and patient and endoscopist satisfaction in ERCP with anesthesiologist-administered sedation Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures A screening instrument for sleep apnea predicts airway maneuvers in patients undergoing advanced endoscopic procedures High-flow nasal interface improves oxygenation in patients undergoing bronchoscopy A nasal high-flow system prevents hypoxia in dental patients under intravenous sedation Clinical evidence on high flow oxygen therapy and active humidification in adults High-flow nasal cannula oxygen therapy in adults High-flow nasal oxygen availability for sedation decreases the use of general anesthesia during endoscopic retrograde cholangiopancreatography and endoscopic ultrasound Optimizing oxygenation and intubation conditions during awake fibre-optic intubation using a high-flow nasal oxygen-delivery system Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE): a physiological method of increasing apnoea time in patients with difficult airways SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Not applicable. ERCP procedures are unique in terms of their presentation. keywords: ercp; flow; groups; hfnc; nasal; oxygen; patients; procedure; sedation; trial cache: cord-336368-sudi4mdx.txt plain text: cord-336368-sudi4mdx.txt item: #2421 of 2876 id: cord-336390-ptnpgh3j author: Passamonti, Francesco title: Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study date: 2020-08-13 words: 4679 flesch: 32 summary: Raccomandazioni per il corretto prelievo, conservazione e analisi sul tampone oro/rino-faringeo per la diagnosi di COVID-19 Sorveglianza Integrata COVID-19 in Italia COVID-19 in solid organ transplant recipients: initial report from the US epicenter Characteristics and outcomes of recipients of heart transplant with coronavirus disease 2019 Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19 Observational study of hydroxychloroquine in hospitalized patients with Covid-19 Effective treatment of severe COVID-19 patients with tocilizumab The role of JAK2 inhibitors in MPNs 7 years after approval Outcomes of COVID-19 in patients with CLL: a multicenter, international experience The study is supported by the charity Associazione italiana contro le leucemie, linfomi e mieloma-Varese Onlus. As of Aug 2, 2020, there have been more than 18·1 million cases of SARS-CoV-2 infection worldwide, with comorbidities shown to affect disease severity and patient outcomes. keywords: cohort; covid-19; data; disease; malignancies; malignancy; mortality; non; patients; population; study; survival cache: cord-336390-ptnpgh3j.txt plain text: cord-336390-ptnpgh3j.txt item: #2422 of 2876 id: cord-336395-v157jzvv author: Battaglini, Denise title: Chest physiotherapy: an important adjuvant in critically ill mechanically ventilated patients with COVID-19 date: 2020-08-17 words: 7012 flesch: 29 summary: Recent manuscripts on respiratory physiotherapy in COVID-19 patients provided general recommendations but did not focus on critically ill COVID-19 cases (Lazzeri et al., 2020; Thomas et al., 2020) . Sputum production was reported in about 34% of COVID-19 patients (Guan et al., 2020) , thus suggesting that, by promoting mucus clearance during mechanical ventilation, early physiotherapy interventions (such as subglottic secretion drainage, postural hygiene, and ventilator hyperinflation) may produce beneficial effects in this new critically ill population (Thomas et al., 2020) . keywords: chest; covid-19; et al; extubation; icu; lung; patients; physiotherapy; position; pressure; risk; thomas; ventilator cache: cord-336395-v157jzvv.txt plain text: cord-336395-v157jzvv.txt item: #2423 of 2876 id: cord-336423-rs4bma9b author: Endersby, Ryan Vincent William title: Barrier Devices for Reducing Aerosol and Droplet Transmission in Coronavirus Disease 2019 Patients: Advantages, Disadvantages, and Alternative Solutions date: 2020-05-12 words: 644 flesch: 53 summary: Brown et al 1 and Babazade et al 4 describe the use of plastic drapes, whereas Lai and Chang 2 and Tsai 3 describe rigid box designs. Rigid box designs significantly limit forearm and hand movements and might require some practice to achieve competence in use. keywords: plastic cache: cord-336423-rs4bma9b.txt plain text: cord-336423-rs4bma9b.txt item: #2424 of 2876 id: cord-336438-mlgxiyur author: Huda, Farhanul title: Covid-19 and surgery: Challenging issues in the face of new normal – A narrative review date: 2020-10-23 words: 4931 flesch: 46 summary: It's bad for you and for hospitals American College of Surgeons, COVID-19 Guidelines for triage of cancer surgery patients Guiding Principles for Cancer Surgery during the COVID-19 Pandemic Emergency surgery in suspected COVID-19 patients with acute abdomen: case series and perspectives Emergency Surgery in Suspected COVID-19 Patients With Acute Abdomen: Case Series and Perspectives National Health Commission of the People's Republic of China, Diagnosis and treatment of novel coronavirus pneumonia COVID-19 and the Risk to Health Care Workers: A Case Report AMASI (Association of Minimal Access Surgeons of India) Guidelines for Conducting Minimal Access Surgery during COVID-19 Pandemic SAGES and EAES recommendations for minimally invasive surgery during COVID-19 pandemic Guiding airway management and personal protective equipment for COVID-19 intubation teams Appropriate Use of Laparoscopy over Open Procedures in the Current COVID-19-19 Climate? It should retrieve data on the availability of resources and their utilization, COVID-19 awareness data amongst HCWs and community, management of COVID-19 patients, and errors during management, complications, and the means to rectify those. keywords: care; consent; covid-19; hospital; infection; pandemic; patients; risk; surgery cache: cord-336438-mlgxiyur.txt plain text: cord-336438-mlgxiyur.txt item: #2425 of 2876 id: cord-336450-2ndan331 author: Shaw, Katharina S. title: Response to “Patient preference for cellulitis treatment: at-home care is preferred to hospital-based treatment” date: 2020-08-07 words: 426 flesch: 31 summary: Moreover, given that patients may be reluctant to seek hospital-74 based care, we highlight the need to remain accessible to patients in the outpatient setting or 75 through virtual visits, particularly during periods of stress on local hospital systems. key: cord-336450-2ndan331 authors: Shaw, Katharina S.; Karagounis, Theodora K.; Yin, Lu; Gibbon, Grace; Betensky, Rebecca A.; Lo Sicco, Kristen I.; Femia, Alisa N. title: Response to “Patient preference for cellulitis treatment: at-home care is preferred to hospital-based treatment” date: 2020-08-07 journal: J Am Acad Dermatol DOI: 10.1016/j.jaad.2020.07.120 sha: doc_id: 336450 cord_uid: 2ndan331 nan preference of patients for at-home treatment of cellulitis rather than hospital-based care. keywords: hospital; patients cache: cord-336450-2ndan331.txt plain text: cord-336450-2ndan331.txt item: #2426 of 2876 id: cord-336462-7dltsav4 author: Trovik, Linn Hereide title: Hemophagocytic lymphohistiocytosis and miliary tuberculosis in a previously healthy individual: a case report date: 2020-11-11 words: 4241 flesch: 33 summary: Choose BMC Treatment outcomes and prognostic factors in adult patients with secondary hemophagocytic lymphohistiocytosis not associated with malignancy A consensus review on malignancy-associated hemophagocytic lymphohistiocytosis in adults COVID-19: consider cytokine storm syndromes and immunosuppression High serum ferritin concentration in an AIDS patient with miliary tuberculosis Immune thrombocytopenia secondary to tuberculosis: a case and review of literature Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: an analysis of 8 clinical cases HLH associated with disseminated tuberculosis Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations However, these findings could not exclude TB infection. keywords: bone; diseases; failure; hlh; infection; lymphohistiocytosis; miliary; patient; treatment; tuberculosis cache: cord-336462-7dltsav4.txt plain text: cord-336462-7dltsav4.txt item: #2427 of 2876 id: cord-336488-opjjowcq author: Kenanidis, Eustathios title: Organizing an Orthopaedic Department During COVID-19 Pandemic to Mitigate In-Hospital Transmission: Experience From Greece date: 2020-06-17 words: 3388 flesch: 39 summary: Pregnant, immunocompromised or over 60 years of age staff were protected; thus, we preferred to involve healthy younger personnel for the care of COVID-19 patients [12] . Two operating theatre complexes with negative pressure and ventilation systems and an integrated high-efficiency particulate air (HEPA) filter to decrease viral dissemination were chosen for surgery of COVID-19 patients [7, 9, 12, 15] . keywords: care; covid-19; hospital; orthopaedic; patients; sars; surgery; transmission cache: cord-336488-opjjowcq.txt plain text: cord-336488-opjjowcq.txt item: #2428 of 2876 id: cord-336543-ydrmlujj author: Cavalli, Eugenio title: Entangling COVID-19 associated thrombosis into a secondary antiphospholipid antibody syndrome: Diagnostic and therapeutic perspectives (Review) date: 2020-06-25 words: 5864 flesch: 30 summary: cOVId-19 pathophysiology: A review al; china Medical Treatment Expert group for covid-19: clinical characteristics of coronavirus disease 2019 in china The epidemiology and pathogenesis of coronavirus disease (cOVId-19) outbreak Physiological and pathological regulation of AcE2, the SARS-coV-2 receptor A pneumonia outbreak associated with a new coronavirus of probable bat origin differential expression of neuronal AcE2 in transgenic mice with overexpression of the brain renin-angiotensin system Boone cE and deconde AS: Association of chemosensory dysfunction and cOVId-19 in patients presenting with influenza-like symptoms Early transmission dynamics in Wuhan, china, of novel coronavirus-infected pneumonia Updated understanding of the outbreak of 2019 novel coronavirus (2019-ncoV) in Wuhan, china Features, evaluation and treatment coronavirus The extent of transmission of novel coronavirus in Wuhan, china, 2020 Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia cOVId-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis Analysis of coagulation parameters in patients with cOVId-19 in Shanghai, china Venous and arterial thromboembolic complications in cOVId-19 patients admitted to an academic hospital in Supported by the ESc Working group on Pulmonary circulation and Right Ventricular Function: cOVId-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JAcc State-of-the-Art Review Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy More on cOVId-19 coagulopathy in caucasian patients Thromboembolic events and apparent heparin resistance in patients infected with SARS-coV-2 The pathogenesis and treatment of the 'cytokine Storm' in cOVId-19 In the eye of the cOVId-19 cytokine storm complement associated microvascular injury and thrombosis in the pathogenesis of severe cOVId-19 infection: A report of five cases complement as a target in cOVId-19? Will complement inhibition be the new target in treating cOVId-19-related systemic thrombosis? The beneficial effects observed with hydroxychloroquine in APS patients (26, 43) has also been claimed in cOVId-19 patients but it needs, however, formal demonstration (43, 44) . keywords: abs; anti; aps; covid-19; infection; patients; sars; syndrome; thrombosis cache: cord-336543-ydrmlujj.txt plain text: cord-336543-ydrmlujj.txt item: #2429 of 2876 id: cord-336554-n8n5ii5k author: Singh, Thakur Uttam title: Drug repurposing approach to fight COVID-19 date: 2020-09-05 words: 13068 flesch: 39 summary: Further, darunavir has been used (600 mg tablet every 12 h) along with other anti-viral drugs and supportive therapy in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy [33] . Hydroxychloroquine phosphate (400 mg tablet every 12 h as a loading dose followed 200 mg tablet every 12 h for 10 days) or chloroquine phosphate (250 mg of two tablet every 12 h for 10 days) along with other anti-viral drugs and supportive therapy have been used in the clinical management of COVID-19 patients presented with a range of MEWS from less than 3 to more than 4 in Italy keywords: antiviral; arbidol; clinical; coronavirus; cov2; covid-19; disease; dose; drug; effects; hydroxychloroquine; infection; inhibitors; interferon; lopinavir; patients; protease; remdesivir; ribavirin; ritonavir; sars; study; therapy; tocilizumab; treatment; trial; use cache: cord-336554-n8n5ii5k.txt plain text: cord-336554-n8n5ii5k.txt item: #2430 of 2876 id: cord-336563-hwemigk7 author: Bhimraj, Adarsh title: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 date: 2020-04-27 words: 8317 flesch: 36 summary: A Randomized Control Trial (THDMS-COVID19) High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection Compassionate Use of Remdesivir for Patients with Severe COVID-19 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Vascular and upper gastrointestinal effects of nonsteroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis Nonsteroidal antiinflammatory drugs may affect the presentation and course of community-acquired pneumonia Risks Related to the Use of Non-Steroidal Anti-Inflammatory Drugs in Community-Acquired Pneumonia in Adult and Pediatric Patients Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection (ENACOVID) HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19 Treating COVID-19-Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics Editorial Concern-Possible Reporting of the Same Patients With COVID-19 in Different Reports Steroid therapy and the risk of osteonecrosis in SARS patients: a dose-response meta-analysis The Ebola clinical trials: a precedent for research ethics in disasters Clinical research ethics for critically ill patients: a pandemic proposal Early observational research and registries during the 2009-2010 influenza A pandemic Choosing outcomes for clinical trials: a pragmatic perspective In an open label treatment trial, lopinavir-ritonavir with ribavirin reduced the mortality and requirement of intensive care support of hospitalized SARS patients compared with historical control keywords: clinical; covid-19; disease; evidence; guideline; outcomes; panel; patients; recommendations; risk; sars; studies; treatment; trials; use cache: cord-336563-hwemigk7.txt plain text: cord-336563-hwemigk7.txt item: #2431 of 2876 id: cord-336614-u6alc6rs author: Pérez-Belmonte, Luis M. title: Differences between Clinical Protocols for the Treatment of Coronavirus Disease 2019 (COVID-19) in Andalusia, Spain date: 2020-09-19 words: 4741 flesch: 31 summary: The clinical presentation of the novel COVID-19 may vary from mild cases with fever, fatigue, and cough to moderate-severe cases involving pneumonia and multiorgan failure [10] , and several factors may predispose COVID-19 patients to adverse outcomes. The potential harm, such as delayed viral clearance, increased risk of secondary infection, and hyperglycemia episodes, have led to caution in their routine use in COVID-19 patients unless the patient had other conditions for which these are indicated keywords: covid-19; heparin; hospital; hydroxychloroquine; lopinavir; patients; pneumonia; protocols; treatment cache: cord-336614-u6alc6rs.txt plain text: cord-336614-u6alc6rs.txt item: #2432 of 2876 id: cord-336621-0w3rroir author: Kim, Kyoung Ok title: A first step toward understanding patient safety date: 2016-07-25 words: 3336 flesch: 43 summary: National Patient Safety Agency (GB) GB): National Patient Safety Agency Healthcare safety committee in Japan: mandatory accountability reporting system and punishment A legal framework for improving patient safety in Korea Anaesthesiology as a model for patient safety in health care Development of the NOTECHS (non-technical skills) system for assessing pilots' CRM skills Simulation-based training in anaesthesia crisis resource management (ACRM): a decade of experience Anaesthetists' Non-Technical Skills (ANTS): evaluation of a behavioural marker system Anaesthetists' non-technical skills Foundation History National Patient Safety Foundation (US) National Patient Safety Foundation The characteristics of patient safety culture in Japan, Taiwan and the United States Nurses' perception of error reporting and patient safety culture in Korea Experience and perception on patient safety culture of employees in hospitals Improving verbal communication in critical care medicine New York, Little, Brown and Company Intercultural communication in cognitive values: Americans and Koreans Medical team training: applying crew resource management in the Veterans Health Administration Perspective: a culture of respect, part 1: the nature and causes of disrespectful behavior by physicians Because implementation of the existing system and program requires time, dedication, and financial support, the Korean healthcare industry is in urgent need of developing patient safety policies and putting them into practice to improve patient safety before it is too late. keywords: error; healthcare; human; industry; patient; reporting; safety; system cache: cord-336621-0w3rroir.txt plain text: cord-336621-0w3rroir.txt item: #2433 of 2876 id: cord-336782-0zkb39v1 author: Fraile Gutiérrez, V. title: Narrative review of ultrasound in the management of the critically ill patient with SARS-CoV-2 infection (COVID-19): clinical applications in intensive care medicine date: 2020-11-02 words: 6663 flesch: 39 summary: Recomendations of the Cardiological Intensive Care and CPR Working Group of the Spanish Society of Intensive Care and Coronary Units Point-of-care lung ultrasound in patients with COVID-19 -a narrative review Chinese Critical Care Ultrasound Study G. Findings of lung ultrasonography of novel corona virus pneumonia during the 2019-2020 epidemic COVID-19 outbreak: less stethoscope, more ultrasound Lung ultrasound and B-lines quantification inaccuracy: B sure to have the right solution Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents COVID-19 Lo que el técnico tiene que saber Products with emerging viral pathogens and human coronavirus claims for use against SARS-CoV-2 Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) Verification of Endotracheal Tube Placement The assessment of four different methods to verify tracheal tube placement in the critical care setting Comparison of three different methods to confirm tracheal tube placement in emergency intubation ) for confirming endotracheal tube placement during emergency intubation Confirmation of endotracheal tube placement after intubation using the ultrasound sliding lung sign BLUE-protocol and FALLS-protocol: two applications of lung ultrasound in the critically ill A bedside ultrasound sign ruling out pneumothorax in the critically ill. Lung sliding Thoracic ultrasonography: a narrative review Chest ultrasound in acute respiratory distress syndrome Global and regional diagnostic accuracy of lung ultrasound compared to CT in patients with acute respiratory distress syndrome Relevance of lung ultrasound in the diagnosis of acute respiratory failure: the BLUE protocol Six versus eight and twenty-eight scan sites for B-line assessment: differences in examination time and findings Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment Ultrasound assessment of lung aeration loss during a successful weaning trial predicts postextubation distress* Diagnosis of pneumothorax by radiography and ultrasonography: a meta-analysis Pleural ultrasonography versus chest radiography for the diagnosis of pneumothorax: review of the literature and meta-analysis Thelung point: an ultrasound sign specific to pneumothorax Sonographic diagnosis of pneumothorax Focused abdominal sonogram for trauma: the learning curve of nonradiologist clinicians in detecting hemoperitoneum Pleural ultrasonography Whole Body Ultrasonography in the Critically Ill Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Tissue Plasminogen Activator (tPA) treatment for COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): a case series Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Real-time ultrasound-guided catheterisation of the internal jugular vein: a prospective comparison with the landmark technique in critical care patients Guidelines for performing ultrasound guided vascular cannulation: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists Guidelines on the use of ultrasound guidance for vascular access Anatomical variations in the internal jugular veins of cancer patients affecting central venous access. keywords: acute; cardiac; care; cov-2; covid-19; echocardiography; fig; lung; lung ultrasound; patients; pattern; sars; ultrasound; ventricular cache: cord-336782-0zkb39v1.txt plain text: cord-336782-0zkb39v1.txt item: #2434 of 2876 id: cord-336784-24qizp9k author: Robinson, Victoria A title: Validation of the Provincial Transfer Authorization Centre database: a comprehensive database containing records of all inter-facility patient transfers in the province of Ontario date: 2006-10-06 words: 3035 flesch: 46 summary: Understanding the dynamics of these transfers will provide the foundation to better quantify the impact patient transfers have on the health care system and patient care, including their heavy cost burden. Future research plans for the PTAC database include modelling the relationship of the spread of disease to patient movement among hospitals using Monte Carlo simulation, the linking of patient transfer data to hospital outcome databases and other data sources and modelling patient movement throughout the healthcare system. keywords: data; facility; patient; ptac; record; transfer cache: cord-336784-24qizp9k.txt plain text: cord-336784-24qizp9k.txt item: #2435 of 2876 id: cord-336790-29im4gxw author: Violetis, Odyssefs A. title: COVID-19 Infection and Haematological Involvement: a Review of Epidemiology, Pathophysiology and Prognosis of Full Blood Count Findings date: 2020-06-29 words: 2667 flesch: 38 summary: A novel coronavirus from patients with pneumonia in China Identification of a novel coronavirus in patients with severe acute respiratory syndrome Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome Cardiovascular disease and COVID-19 Neurologic manifestations of hospitalized patients with coronavirus disease COVID-19 and its implications for thrombosis and anticoagulation COVID-19 and thrombotic or thromboembolic disease : implications for prevention, antithrombotic therapy and follow-up Covid-19 and the digestive system COVID-19: consider cytokine storm and immunosuppression Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis Complex immune dysregulation in COVID-19 patients with severe respiratory failure Dysregulation of immune response in patients with COVID-19 in Wuhan, China The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks Eosinophil count in severe coronavirus disease 2019 Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa Hematological findings and complications of COVID-19 Hematologic parameters in patients with COVID-19 infection Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington state Suppressed T cell-mediated immunity in patients with COVID-19: a clinical retrospective study in Wuhan Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis Mechanism of thrombocytopenia in COVID-19 patients Platelet biogenesis in the lung circulation Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia A meta-analysis conducted by Lippi G. et al. included 9 studies with a total of 1779 COVID-19 patients examining the association between thrombocytopenia and severity of the disease. keywords: coronavirus; count; covid-19; disease; infection; patients cache: cord-336790-29im4gxw.txt plain text: cord-336790-29im4gxw.txt item: #2436 of 2876 id: cord-336810-77wq9laa author: Klocperk, Adam title: Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19 date: 2020-09-17 words: 4688 flesch: 36 summary: Individually, laboratory abnormalities have been reported in COVID-19 patients, including an elevation of inflammatory markers and liver enzymes, abnormal renal function tests, and an elevated serum soluble interleukin 2 (IL-2) receptor (sIL2R) and IL-6. As a contribution to the current knowledge pool, our report describes a representative cohort of COVID-19 patients hospitalized during the pandemic in a large Czech hospital. keywords: cells; course; covid-19; disease; elevation; figure; liver; markers; patients; sars; study cache: cord-336810-77wq9laa.txt plain text: cord-336810-77wq9laa.txt item: #2437 of 2876 id: cord-336882-x9e6r0h0 author: Sambare, Tanmaya title: Preparing for an Era of Episode-Based Care in Total Joint Arthroplasty date: 2020-09-22 words: 1191 flesch: 26 summary: Recent developments related to value improvement in total joint arthroplasty suggest episode-based payment is likely to become standard practice given the current healthcare environment. Consequently, developing episode-based care models for total joint arthroplasty is in the best interests of surgeons, health systems, and patients. keywords: arthroplasty; care; joint; patient cache: cord-336882-x9e6r0h0.txt plain text: cord-336882-x9e6r0h0.txt item: #2438 of 2876 id: cord-337010-dgy7qbl5 author: Tomazini, B. M. title: COVID-19-associated ARDS treated with DEXamethasone (CoDEX): Study design and rationale for a randomized trial. date: 2020-06-26 words: 5125 flesch: 42 summary: Also, due to the lack of data about ventilator free days in COVID-19 patients, the sample size will be updated using the pooled standard deviation of ventilator free days of the first interim analysis, unless by the time of the first interim analysis all patients have been recruited. Unidentified patient data will be collected through an electronic online data capture tool (REDCap) 22 23 . keywords: ards; covid-19; data; days; license; medrxiv; medrxiv preprint; patients; preprint; trial; use cache: cord-337010-dgy7qbl5.txt plain text: cord-337010-dgy7qbl5.txt item: #2439 of 2876 id: cord-337088-xxyhmn1t author: Malhotra, Naveen title: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement regarding COVID-19 date: 2020-03-28 words: 1323 flesch: 50 summary: key: cord-337088-xxyhmn1t authors: Malhotra, Naveen; Joshi, Muralidhar; Datta, Rashmi; Bajwa, Sukhminder Jit Singh; Mehdiratta, Lalit title: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement regarding COVID-19 date: 2020-03-28 journal: Indian J Anaesth DOI: 10.4103/ija.ija_288_20 sha: doc_id: 337088 cord_uid: xxyhmn1t nan Indian Society of Anaesthesiologists issues the following advisory and position statement to ensure safety of patients and the anaesthesiologists during the Corona Virus Disease 2019 in India. Infection Prevention and Control policies have to be followed religiously. Anaesthesiologist interaction with patients with COVID-19 can occur in Accident and Emergency Department/Trauma Centre for emergency airway management; Critical Care/Intensive Care Units; Pre-Anaesthetic Check Up (PAC) Clinics and Pain Clinics; Perioperative Anaesthesia Care; and Anaesthesia at remote locations: endoscopy, ECT, Radiology (MRI) etc., The anaesthesiologists have to take care of the patients as well as themselves. keywords: anaesthesiologists; care; clinics; pac; patients cache: cord-337088-xxyhmn1t.txt plain text: cord-337088-xxyhmn1t.txt item: #2440 of 2876 id: cord-337094-aa3ourc6 author: Ramella, Vittorio title: Microsurgical reconstruction in the time of COVID‐19 date: 2020-05-15 words: 564 flesch: 48 summary: For these reasons and for the patient's comorbidities, we decided on conservative non-microsurgical treatment (debridement, external fixation and direct closure of the wound) to simplify the postoperative management of the Covid-19 positive patient. It is well known that timely start of surgical treatment is associated with higher survival rates in patients with head and neck cancer (Graboyes et al., 2019) . keywords: covid-19; patient cache: cord-337094-aa3ourc6.txt plain text: cord-337094-aa3ourc6.txt item: #2441 of 2876 id: cord-337115-vtjsigod author: Liao, Xuelian title: Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China date: 2020-02-05 words: 1387 flesch: 42 summary: Clinical features of patients infected with 2019 novel coronavirus in Wuhan A novel coronavirus outbreak of global health concern Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic Intensive care unit preparedness during pandemics and other biological threats From SARS to avian influenza preparedness in Hong Kong Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected A risk classification model to predict mortality among laboratory-confirmed avian influenza A H7N9 patients: a population-based observational cohort study A comparison of the quick sequential (sepsis-related) organ failure assessment score and the national early warning score in non-ICU patients with/without infection Coronavirus infections-more than just the common cold Data sharing and outbreaks: best practice exemplified Third, we assigned special work such as patient screening, consultation, and transfer to designated staff to minimize the number of health workers who had contact with patients with nCoV infection. keywords: care; infection; ncov; patients; staff cache: cord-337115-vtjsigod.txt plain text: cord-337115-vtjsigod.txt item: #2442 of 2876 id: cord-337120-irpm5g7g author: Lee, Bruce Y. title: The Role of Internists During Epidemics, Outbreaks, and Bioterrorist Attacks date: 2007-01-13 words: 3380 flesch: 37 summary: Although Internists may feel compelled to acquiesce to every patient's needs, their primary responsibility in public health emergencies is the public. Responding to the epidemic of severe acute respiratory syndrome A major outbreak of severe acute respiratory syndrome in Hong Kong The outbreak of West Nile virus infection in the New York City area in 1999 The public and the smallpox threat BioSTORM: a system for automated surveillance of diverse data sources Data, network, and application: technical description of the Utah RODS Winter Olympic Biosurveillance System Role of data aggregation in biosurveillance detection strategies with applications from ESSENCE Index case of fatal inhalational anthrax due to bioterrorism in the United States Emergency preparedness and response Accuracy of screening for inhalational anthrax after a bioterrorist attack Anthrax as a biological weapon, 2002: updated recommendations for management Bioterrorism and critical care NATO Handbook on the medical aspects of NBC defensive operations AmedP-6 Departments of the Army, the Navy, and the Air Force APIC Bioterrorism Task Force and CDC Hospital Infections Program Bioterrorism Working Group bioterrorism readiness plan: a template for healthcare facilities A massive outbreak in Milwaukee of cryptosporidium infection transmitted through the public water supply An outbreak of hepatitis A associated with green onions Crow deaths as a sentinel surveillance system for West Nile virus in the northeastern United States Dead crow densities and human cases of West Nile virus Tularemia transmitted by insect bites-Wyoming Clinical decision making during public health emergencies: ethical considerations Symptoms of posttraumatic stress disorder and depression among children in tsunami-affected areas in southern Thailand Mental health problems among adults in tsunami-affected areas in southern Thailand Surveillance for World Trade Center disaster health effects among survivors of collapsed and damaged buildings Media exposure in children one hundred miles from a terrorist bombing Posttraumatic stress two years after the Oklahoma City bombing in youths geographically distant from the explosion Referral gridlock: primary care physicians and mental health services Posttraumatic stress disorder in rural primary care: improving care for mental health following bioterrorism The impact of terrorism on brain, and behavior: what we know and what we need to know. keywords: attacks; bioterrorist; care; disease; emergency; health; internists; patients; public; state cache: cord-337120-irpm5g7g.txt plain text: cord-337120-irpm5g7g.txt item: #2443 of 2876 id: cord-337262-88qpfu6b author: File, Thomas M. title: 26 Community-Acquired Pneumonia, Bacterial date: 2012-12-31 words: 3515 flesch: 30 summary: Because false-positive blood cultures may be more common than pathogen-positive blood cultures from patients admitted to a general ward, they may have limited benefit for such patients and are considered optional in recent guidelines. Such patients often have necrotizing pneumonia and abscesses (see Figure 26 -2). keywords: cap; cause; mrsa; patients; pneumonia; risk; therapy; treatment cache: cord-337262-88qpfu6b.txt plain text: cord-337262-88qpfu6b.txt item: #2444 of 2876 id: cord-337297-fkw8780t author: Fan, Siyuan title: Neurological Manifestations in Critically Ill Patients With COVID-19: A Retrospective Study date: 2020-07-10 words: 4703 flesch: 36 summary: Similarly, in a previous report of COVID-19 patients with ischemic stroke, all six stroke patients had large-vessel occlusion and three of them had multiterritory infarcts (21) . Furthermore, compared with patients without a cerebrovascular event, a significantly higher prevalence of antiphospholipid antibodies was observed in stroke patients. keywords: case; complications; coronavirus; covid-19; disease; ischemic; patients; sars; stroke; study cache: cord-337297-fkw8780t.txt plain text: cord-337297-fkw8780t.txt item: #2445 of 2876 id: cord-337302-fpz2jfuj author: Abdihamid, Omar title: The Landscape of COVID-19 in Cancer Patients: Prevalence, Impacts, and Recommendations date: 2020-09-23 words: 5970 flesch: 43 summary: The infection rate of SARS-CoV-2 in cancer patients in China was 0.79% (12 of 1524 patients; 95% CI, 0.31.2%). The case fatality rate of COVID-19 in the overall population ranges from 2.3 to 8.0%; among these, the case fatality rate for cancer patients is at 5.6%. keywords: cancer; care; china; coronavirus; cov-2; covid-19; disease; pandemic; patients; risk; sars; study; treatment cache: cord-337302-fpz2jfuj.txt plain text: cord-337302-fpz2jfuj.txt item: #2446 of 2876 id: cord-337338-7uj2r0gy author: Ohlstein, Jason F. title: Telemedicine in Otolaryngology in the COVID‐19 Era: Initial Lessons Learned date: 2020-08-02 words: 3257 flesch: 42 summary: Distribution of reported reasons for declining Telemedicine visits. Date of visit was calculated by counting the number of days from initiation of shelter in place orders to date of scheduled clinic visit, median visit dates were created for those who accepted and declined Telemedicine visits. keywords: care; covid-19; otolaryngology; patients; study; telemedicine; visit cache: cord-337338-7uj2r0gy.txt plain text: cord-337338-7uj2r0gy.txt item: #2447 of 2876 id: cord-337431-3rrvm787 author: Dimopoulos, G title: Viral Profile of COPD Exacerbations According to Patients§ date: 2015-02-23 words: 3224 flesch: 37 summary: RESULTS : 247 patients (median age: 69.3±9.5 years) were recruited and categorized into group A: non-elderly patients [n=81 (32.8%), median age 58±5.99] and group B: elderly patients [n=166 (67.2%), median age 74.8±4.8] years. Up to date most of the efforts are small single center cohorts that have tried to study elderly patients together with specific characteristics and risk factors associated with certain infection keywords: aecopd; copd; disease; infections; non; patients; pulmonary; study cache: cord-337431-3rrvm787.txt plain text: cord-337431-3rrvm787.txt item: #2448 of 2876 id: cord-337487-1lbopaso author: Hansildaar, Romy title: Cardiovascular risk in inflammatory arthritis: rheumatoid arthritis and gout date: 2020-09-01 words: 9481 flesch: 27 summary: However, over the past 20 years several nontraditional risk factors, such as chronic inflam mation, have emerged as amplifiers of cardiovascular disease risk. The recognition of an increased cardiovascular disease risk in arthritis prompted the European League Against Rheumatism (EULAR) to set out evidencebased recom mendations for the management of cardiovascular disease risk in inflammatory arthritis, and these guidelines were updated in 2017. keywords: arthritis; cardiovascular; disease; effects; failure; gout; heart; inflammation; management; mortality; patients; review; rheumatoid; rheumatoid arthritis; risk; study; therapy; treatment; urate cache: cord-337487-1lbopaso.txt plain text: cord-337487-1lbopaso.txt item: #2449 of 2876 id: cord-337520-qp0ga6q8 author: Binning, Mandy title: Cardiopulmonary resuscitation causing thoracolumbar hyperextension with severe spinal cord injury: A case report date: 2020-09-03 words: 1641 flesch: 42 summary: E-mail address: kjgreenb@gmail.com (K. Greenberg). of the ribs and sternum, are the most frequently reported complications of chest compressions. Multiple bilateral rib fractures compatible with sequela of chest compressions were also demonstrated. keywords: cpr; patient; spinal cache: cord-337520-qp0ga6q8.txt plain text: cord-337520-qp0ga6q8.txt item: #2450 of 2876 id: cord-337622-rc9pejmo author: Sansom‐Daly, Ursula M. title: Grappling with the ‘human’ problem hiding behind the technology: Telehealth during and beyond COVID‐19 date: 2020-07-06 words: 2636 flesch: 51 summary: -Safety discussed with new patients upfront, also ensuring we had their home contact details in case concerns arose. This was especially helpful as rapport-building for new patients. keywords: article; copyright; face; patients; rights; telehealth cache: cord-337622-rc9pejmo.txt plain text: cord-337622-rc9pejmo.txt item: #2451 of 2876 id: cord-337644-aobdzwpx author: Pianta, L. title: Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date: 2020-05-24 words: 1745 flesch: 47 summary: There were 14 patients in group 1 (standard treatment) (7 females and 7 males, aged 33-73 years), and 15 patients in group 2 (acetic acid treatment) (11 males and 4 females, aged 49-80 years). The aim of this paper is to evaluate the effect of acetic acid, the active component of vinegar, as a potential disinfectant agent for upper airways. keywords: acid; covid-19; group; patients; symptoms cache: cord-337644-aobdzwpx.txt plain text: cord-337644-aobdzwpx.txt item: #2452 of 2876 id: cord-337665-roelk7i5 author: Bhattacharjee, Hemanga K. title: Emergency Surgery during COVID-19: Lessons Learned date: 2020-09-30 words: 2953 flesch: 50 summary: Operating upon COVID-19 patients is both resource consuming and stressful for the surgeons. Although he had no known contact with COVID-19 patients but a few of his symptoms resembled that of COVID-19. keywords: covid-19; emergency; hospital; pandemic; patients; surgery; volvulus cache: cord-337665-roelk7i5.txt plain text: cord-337665-roelk7i5.txt item: #2453 of 2876 id: cord-337896-mct29erg author: Kornbluth, Asher title: Management of Inflammatory Bowel Disease and COVID-19 in New York City 2020: The Epicenter of IBD in the First Epicenter of the Global Pandemic date: 2020-09-03 words: 5119 flesch: 50 summary: Our extensive experience in caring for IBD patients with COVID-19 stems from our practice in which we have a very large IBD patient population of Ashkenazi Orthodox and Hasidic Jews that comprises nearly 75% of our cohort. SECURE-IBD Database Public Data Update New York Times Corona Virus Map and Cases Count COVID-19 (Coronavirus): What IBD Patients Should Know BSG) advice for management of inflammatory bowel diseases during the COVID-19 pandemic AGA clinical practice update on management of inflammatory bowel disease during the COVID-19 pandemic: expert commentary IOIBD COVID-19 Webinars and Guidelines. keywords: cov-2; covid-19; disease; ibd; new; nyc; office; patients; practice; sars; visits cache: cord-337896-mct29erg.txt plain text: cord-337896-mct29erg.txt item: #2454 of 2876 id: cord-337898-ncrbd8rp author: Pal, Rimesh title: Comment on “Is the type of diabetes treatment relevant to outcome of COVID‐19?” date: 2020-05-27 words: 1080 flesch: 37 summary: The concept of harnessing the pleiotropic antiinflammatory properties of anti-diabetic medications in management of early/advanced COVID-19 in people with diabetes mellitus (DM) is intriguing. Pioglitazone improves glucose metabolism and modulates skeletal muscle TIMP-3-TACE dyad in type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled, mechanistic study Should anti-diabetic medications be reconsidered amid COVID-19 pandemic? keywords: covid-19; diabetes; patients cache: cord-337898-ncrbd8rp.txt plain text: cord-337898-ncrbd8rp.txt item: #2455 of 2876 id: cord-337906-qis8h3r3 author: Suresh Kumar, Vishnu Charan title: Transaminitis is an indicator of mortality in patients with COVID-19: A retrospective cohort study date: 2020-09-27 words: 3093 flesch: 48 summary: The existing literature points towards diarrhea as the most common GI complaint in COVID-19 patients [6, 7, 9, 10] . AIM: To describe the demographic and clinical characteristics of COVID-19 positive patients and study the association between transaminitis and all-cause mortality. keywords: coronavirus; covid-19; patients; study; transaminitis cache: cord-337906-qis8h3r3.txt plain text: cord-337906-qis8h3r3.txt item: #2456 of 2876 id: cord-337926-6ddvqowr author: Farrell, Sarah title: Recommendations for the Care of Pediatric Orthopaedic Patients During the COVID Pandemic date: 2020-04-14 words: 3107 flesch: 41 summary: These guidelines, based on expert opinion and best available evidence, provide a framework for the management of pediatric orthopaedic patients during the COVID pandemic. The authors would also like to thank Wendy Krishnaswamy, RN, for providing her valued perspective from a nursing standpoint on orthopaedic patient management and consideration of patient families. keywords: covid; healthcare; management; orthopaedic; pandemic; patients; surgeons; treatment cache: cord-337926-6ddvqowr.txt plain text: cord-337926-6ddvqowr.txt item: #2457 of 2876 id: cord-337965-z39q8ebq author: Kvernland, Alexandra title: Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System date: 2020-08-24 words: 3755 flesch: 32 summary: Moreover, there are limited data on the incidence of hemorrhagic stroke patients with COVID- 19. Larger studies are needed to further validate the clinical characteristics we found significant and further studies to evaluate the risks and benefits of therapeutic anticoagulation in stroke patients with COVID-19. keywords: anticoagulation; controls; covid-19; diagnosis; hemorrhagic; patients; stroke; study; time cache: cord-337965-z39q8ebq.txt plain text: cord-337965-z39q8ebq.txt item: #2458 of 2876 id: cord-337994-pkklt77i author: Brouqui, P. title: Remdesivir investigational trials in COVID-19: a critical reappraisal date: 2020-06-07 words: 2082 flesch: 55 summary: Altogether, any serious adverse 116 event is reported in 27.7% of treated patient among them 4.7% of acute kidney injury. 125 As today no study convincingly supports the use of remdesivir in severe patients. keywords: covid-19; patients; remdesivir; treatment cache: cord-337994-pkklt77i.txt plain text: cord-337994-pkklt77i.txt item: #2459 of 2876 id: cord-337995-z4rcczki author: Moris, Dimitrios title: Kidney Transplant Recipients Infected By COVID‐19: Review of the Initial Published Experience date: 2020-07-23 words: 2738 flesch: 33 summary: Regarding radiographic findings in KTx COVID-19 patients, 78.5% presented with bilateral ground glass opacities in both chest plain radiograph and CT-scan of the chest 18, 19, 21-28, 30-34, 36-42, 44, 46-54 . All rights reserved A novel coronavirus outbreak of global health concern Challenges in Abdominal Organ Transplantation During the COVID-19 Pandemic Coronavirus breakthrough: dexamethasone is first drug shown to save lives Tocilizumab's efficacy in COVID-19 patients is determined by the presence of cytokine storm COVID-19 in solid organ transplantation patients: A systematic review Evidence Supporting Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 While Presymptomatic or Asymptomatic COVID-19 in solid organ transplant recipients: keywords: article; covid-19; kidney; ktx; patients; recipients; transplant cache: cord-337995-z4rcczki.txt plain text: cord-337995-z4rcczki.txt item: #2460 of 2876 id: cord-338023-gb5jgqcg author: Obara, Shinju title: Anesthesiologist behavior and anesthesia machine use in the operating room during the COVID-19 pandemic: awareness and changes to cope with the risk of infection transmission date: 2020-08-27 words: 2823 flesch: 32 summary: The effects of such measures even in COVID-19 patients should be studied in the future. APSF/ASA Guidance on Purposing Anesthesia Machines as ICU Ventilators A process for daily checks when using anaesthetic machines to ventilate the lungs of COVID-19 patients: the 'domino switch' technique Remote control and monitoring of Ge Aisys anesthesia machines repurposed as intensive care unit ventilators Shared ventilation: toward safer ventilator splitting in resource emergencies International guidelines and recommendations for surgery during Covid-19 pandemic: a systematic review Air contamination with SARS-CoV-2 in the operating room Human papillomavirus DNA in surgical smoke during cervical loop electrosurgical excision procedures and its impact on the surgeon Electrocautery, diathermy, and surgical energy devices: are surgical teams at risk during the COVID-19 pandemic? keywords: anesthesia; cov-2; covid-19; infection; patients; sars; use cache: cord-338023-gb5jgqcg.txt plain text: cord-338023-gb5jgqcg.txt item: #2461 of 2876 id: cord-338131-6y96eyoq author: Galvez, A. title: Perforated Marginal Ulcer in a COVID-19 Patient. Laparoscopy in these Trying Times? date: 2020-05-24 words: 1335 flesch: 44 summary: Despite current surgical recommendations [1] advising against routine laparoscopy in COVID-19 patients for aerosolization concerns; a laparoscopic approach was decided given availability of laparoscopic high-efficiency particulate air (HEPA) filters (PlumePort® ActiV®. Recent reports of poor outcomes in COVID-19 patients undergoing extensive open abdominal surgery [2] were also taken into account. keywords: approach; covid-19; day; management; patient cache: cord-338131-6y96eyoq.txt plain text: cord-338131-6y96eyoq.txt item: #2462 of 2876 id: cord-338135-zwo7e7gy author: Melis, Daniele title: Clinical efficacy, speed of improvement and safety of apremilast for the treatment of adult Psoriasis during COVID‐19 pandemic date: 2020-05-30 words: 1520 flesch: 40 summary: Real world case series are suggesting a more consistent improvement, and with this additional personal investigation on 48 patients, we signal that 58% of patients achieved PASI50, and 19% PASI75 improvement in the first 8 weeks of treatment. Results at 16‐week are remarkable, with overall 55% of patients achieving PASI 75, 21% PASI 90 and 14% PASI 100. keywords: apremilast; pasi; patients; psoriasis cache: cord-338135-zwo7e7gy.txt plain text: cord-338135-zwo7e7gy.txt item: #2463 of 2876 id: cord-338146-am5gg1qd author: Bindi, E. title: Meckel's diverticulum perforation in a newborn positive to Sars-Cov-2 date: 2020-08-29 words: 1737 flesch: 44 summary: With the explosion of the Sars-Cov-2 pandemic, work has multiplied in the literature on the clinical conditions of infected patients, but only a few of these take surgical patients into consideration. As far as we know, in Literature there are no cases of pediatric patients with surgical pathology related to coronavirus disease 2019 (COVID-19), and let alone, there is still no data on a possible relationship between the infection and the onset of surgical complications. keywords: diverticulum; meckel; patient cache: cord-338146-am5gg1qd.txt plain text: cord-338146-am5gg1qd.txt item: #2464 of 2876 id: cord-338182-cetv78ba author: Zurita-Cruz, Jessie title: The Impact of a History of Pre-maturity on Viral Respiratory Infections in Children Under 2 Years of Age: A Propensity Score-Matching Analysis of in-hospital Complications and Mortality date: 2020-09-18 words: 3518 flesch: 36 summary: Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study Community-acquired pneumonia requiring hospitalization Infant immune response to respiratory viral infections Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Respiratory syncytial virus Respiratory syncytial virus hospitalizations in healthy preterm infants: systematic review Human respiratory syncytial virus: infection and pathology Challenges in estimating RSV-associated mortality rates Morbidity of parainfluenza 3 outbreak in preterm infants in a neonatal unit Apnea as a presenting symptom in humann metapneumovirus infection Does viral co-infection influence the severity of acute respiratory infection in children? Pediatric acute lung injury epidemiology and natural history study: incidence and outcome of the acute respiratory distress syndrome in children Attenuated interleukin-8/leukocyte immunoresponse in preterm infants compared with term infants hospitalized with respiratory syncytial virus bronchiolitis: a pilot study 15. Regarding hospital complications, the multivariate model showed that invasive medical procedures (OR = 6.13), history of pre-maturity (OR = 2.54), and male sex (OR = 1.78) increased the risk for complications (Table 4A) . keywords: age; complications; history; hospital; maturity; patients; pre cache: cord-338182-cetv78ba.txt plain text: cord-338182-cetv78ba.txt item: #2465 of 2876 id: cord-338192-2v9dbc9h author: Dai, J. D. title: How many patients will need ventilators tomorrow? date: 2020-05-21 words: 3712 flesch: 62 summary: Among L t patients who are not on vent yet on day t, we need to separate them into three types: L 1 t , L 2 t , and L 3 t . . Therefore, we created a simulation model that would generate the number of daily vent-starts and daily hospital census numbers. keywords: day; patients; type; vent cache: cord-338192-2v9dbc9h.txt plain text: cord-338192-2v9dbc9h.txt item: #2466 of 2876 id: cord-338346-e3fk6gz2 author: Oliveros, Estefania title: Coronavirus Disease 2019 and Heart Failure: A Multiparametric Approach date: 2020-08-14 words: 2484 flesch: 37 summary: The Heart Failure Society of America (HFSA) and the Heart Failure Association of the European Society of Cardiology have ensured that HF patients are appropriately informed during the novel COVID-19 pandemic. Similarly, a joint HFSA, America College of Cardiology (ACC) and American Heart Association statement said there were no experimental or clinical data demonstrating beneficial or adverse outcomes with background use of ACE inhibitors, ARBs or other RAAS antagonists among COVID-19 patients with a history of cardiovascular disease treated with such agents. keywords: angiotensin; covid-19; disease; heart; pandemic; patients cache: cord-338346-e3fk6gz2.txt plain text: cord-338346-e3fk6gz2.txt item: #2467 of 2876 id: cord-338362-6zwvkqag author: Cohen, Donald F. title: Ethical practice during the COVID-19 pandemic date: 2020-04-08 words: 948 flesch: 51 summary: 1 We also are engaging in social distancing by reducing the close contact between other patients as well as staff members, thus limiting the risk of harm to patients, staff members, and ourselves. 3 We also are conserving personal protective equipment (PPE) that can be used for patients with urgent needs. keywords: ethics; patients; practice cache: cord-338362-6zwvkqag.txt plain text: cord-338362-6zwvkqag.txt item: #2468 of 2876 id: cord-338419-n8cmv8mf author: Carmelo, Juliana de Carvalho title: Impact of COVID-19 on the daily routine of radiology clinics date: 2020-09-16 words: 1737 flesch: 47 summary: 11 With its high transmissibility and the possibility of asymptomatic carriers, COVID-19 presents a high risk of infection for dental radiology professionals, who could consequently transmit the disease to others. Consequently, many oral problems have been neglected during this period, since patients avoid social interactions and postpone important diagnostic exams. keywords: covid-19; disease; health; patient; transmission cache: cord-338419-n8cmv8mf.txt plain text: cord-338419-n8cmv8mf.txt item: #2469 of 2876 id: cord-338517-1mxcssjj author: Ishay, Yuval title: Antibody response to SARS‐Co‐V‐2, diagnostic and therapeutic implications date: 2020-08-26 words: 7408 flesch: 29 summary: Prior to and concurrently with the isolation of specific antibodies, SARS-CoV S1-specific serum from convalescent SARS patients or from animals was proposed to cross-neutralize the SARS-CoV-2 infection by reducing S proteinmediated SARS-CoV-2 entry (30) . Convalescent plasma or immunoglobulins were effective in SARS patients whose condition continued to deteriorate. keywords: antibodies; antibody; cells; convalescent; coronavirus; cov-2; covid-19; disease; immune; infection; nabs; patients; plasma; response; sars cache: cord-338517-1mxcssjj.txt plain text: cord-338517-1mxcssjj.txt item: #2470 of 2876 id: cord-338600-wpfcxnyu author: Stewart, Cameron title: Mental Capacity Assessments for COVID-19 Patients: Emergency Admissions and the CARD Approach date: 2020-11-09 words: 3109 flesch: 46 summary: We examine the principles of mental capacity and make recommendations on how to assess the capacity of COVID-19 patients to consent to emergency medical treatment. In this article we define mental capacity, restate the legal test, and provide practical advice on how to assess the capacity of COVID-19 patients in emergency and critical care settings, including a short list of questions which flag capacity issues which we refer to as the CARD approach. keywords: capacity; consent; covid-19; decision; information; patients; treatment cache: cord-338600-wpfcxnyu.txt plain text: cord-338600-wpfcxnyu.txt item: #2471 of 2876 id: cord-338602-6n309bnp author: Gadotti, Ana Carolina title: IFN-γ is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection date: 2020-09-23 words: 2892 flesch: 49 summary: Besides it, cytokine storm is also present in severe patients due to elevation of interleukins such as TNF-α, IL-6, IL-8, and IL-10 2, 3 . Lancet Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors. keywords: cells; covid-19; disease; ifn; levels; patients cache: cord-338602-6n309bnp.txt plain text: cord-338602-6n309bnp.txt item: #2472 of 2876 id: cord-338605-3i5pvcgu author: Antoun, Lina title: Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome A prospective cohort study date: 2020-07-15 words: 2331 flesch: 48 summary: [10] of more than 400 pregnant patients hospitalised with COVID-19 suggest an increased potential for adverse maternal outcomes in pregnant patients hospitalised with confirmed COVID-19 infection; while the risk of an intrauterine vertical transmission is inconclusive . Nasal swabs were performed to screen for COVID-19 in seven infants 7/19 (37%) who were delivered to mothers with severe symptoms (one test was not performed as guidance for not routinely performing screening test on the neonates born to COVID-19 patient was changed to routine screening soon after the data collection started). keywords: covid-19; infection; outcomes; patients; pregnancy cache: cord-338605-3i5pvcgu.txt plain text: cord-338605-3i5pvcgu.txt item: #2473 of 2876 id: cord-338666-gg9qcpmz author: Rubin, Geoffrey A. title: Restructuring Electrophysiology During the COVID-19 Pandemic: A Practical Guide From a New York City Hospital Network date: 2020-04-27 words: 4864 flesch: 37 summary: The aims of these recommendations are to outline: (1) essential practical steps to approaching procedures, as well as outpatient and inpatient care of EP patients, with relevant examples, (2) successful strategies to minimize exposure risk to patients and clinical staff while also balancing resource utilization, (3) challenges related to redeployment and restructuring of clinical and support staff, and (4) considerations regarding continued collaboration with clinical and administrative colleagues to implement these changes. Further staff responsibilities include designating colleagues to coordinate research efforts with Institutional Review Board and other departments on topics of more urgent COVID-related interest (e.g., QTc in the setting of COVID-19 treatment, obtaining 7-lead ECGs off telemetry in units since unable to perform frequent 12-lead ECGs on COVID-19 patients). keywords: care; challenges; covid-19; crisis; device; home; hospital; medical; pandemic; patients; risk; staff; system cache: cord-338666-gg9qcpmz.txt plain text: cord-338666-gg9qcpmz.txt item: #2474 of 2876 id: cord-338668-z2z4gte2 author: Veraldi, Stefano title: Seborrheic dermatitis and masks date: 2020-08-13 words: 788 flesch: 56 summary: All patients used anti‐coronavirus‐19 (COVID‐19) face mask for many hours per day. All patients used anticoronavirus-19 (COVID-19) face mask for 6 to 10 hours per day; 7 out of 20 patients (35%) were physicians, obstetricians or nurses. keywords: face; patients cache: cord-338668-z2z4gte2.txt plain text: cord-338668-z2z4gte2.txt item: #2475 of 2876 id: cord-338683-nzgnpi6f author: Karligkiotis, Apostolos title: Changing paradigms in sinus and skull base surgery as the COVID‐19 pandemic evolves: Preliminary experience from a single Italian tertiary care center date: 2020-06-08 words: 4310 flesch: 37 summary: However, after March 23, 2020, indications for PPE use changed and, since then, surgical procedures in COVID-19 negative patients required the use of the highest individual protection standards (at least FFP2 masks), in consideration of the significant number of false negatives resulting from the swab tests currently used. Table 4 provides a summary of the survey conducted, highlighting data regarding exposition to COVID-19 positive patients, the use of PPE and the diagnostic tests performed. keywords: base; care; covid-19; health; pandemic; patients; period; skull; surgery cache: cord-338683-nzgnpi6f.txt plain text: cord-338683-nzgnpi6f.txt item: #2476 of 2876 id: cord-338729-v2suoj3c author: Streicher, Caroline title: Could Tocilizumab be an Attractive Therapeutic Option for Elderly Patients with Severe COVID-19? A Case Report date: 2020-09-20 words: 1639 flesch: 43 summary: Recently, there have been an increased number of studies on the use of tocilizumab treatment for severe COVID-19 patients, but more information is needed on its effectiveness and safety, notably for the treatment of elderly patients. To date, no therapy has been approved for the treatment of COVID-19, but targeting IL-6 with tocilizumab treatment could be a potential therapeutic option for patients with COVID-19-induced CRS keywords: covid-19; day; patients; tocilizumab; treatment cache: cord-338729-v2suoj3c.txt plain text: cord-338729-v2suoj3c.txt item: #2477 of 2876 id: cord-338741-gy3ovkrt author: Sethi, Atin title: Evaluation of Current Therapies for COVID-19 Treatment date: 2020-07-22 words: 5592 flesch: 44 summary: The authors suggested that physicians should test for SARS-CoV-2 antibodies in hospitalized patients before treatment with convalescent plasma. In patients with mechanical ventilation, dexamethasone reduced mortality by 1/3, and by 1/5 in those receiving oxygen alone. keywords: control; cov-2; covid-19; efficacy; hydroxychloroquine; patients; sars; study; treatment; trial; use cache: cord-338741-gy3ovkrt.txt plain text: cord-338741-gy3ovkrt.txt item: #2478 of 2876 id: cord-338756-jzz250o1 author: Zhang, Nan title: Epidemiologic and clinical characteristics of 42 deaths caused by SARS-CoV-2 infection in Wuhan, China: A retrospective study date: 2020-07-15 words: 1647 flesch: 49 summary: Impaired consciousness level, markers of renal impairment and coagulation abnormalities may be poor prognostic factors A Novel Coronavirus from Patients with Pneumonia in China A novel coronavirus outbreak of global health concern Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China A pneumonia outbreak associated with a new coronavirus of probable bat origin Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia The data suggested that disseminated intravascular coagulation (DIC) was associated with the outcomes of death, in patients with COVID-19 infection. keywords: covid-19; infection; patients; risk cache: cord-338756-jzz250o1.txt plain text: cord-338756-jzz250o1.txt item: #2479 of 2876 id: cord-338900-8ojah695 author: MacDonald, David S. MacDonald title: Guidelines for Oral and Maxillofacial Imaging: COVID-19 Considerations date: 2020-10-26 words: 5711 flesch: 37 summary: COVID-19 Considerations date: 2020-10-26 journal: Oral Surg Oral Med Oral Pathol Oral Radiol DOI: 10.1016/j.oooo.2020.10.017 sha: doc_id: 338900 cord_uid: 8ojah695 SARS-CoV-2, the virus causing the current COVID-19 pandemic, is not only highly infectious but can induce serious outcomes in vulnerable individuals including dental patients and dental health care providers (DHCP). A meta-analysis The emerging role of maxillofacial radiology in the diagnosis and management of patients with complex periodontitis Accuracy of extraoral bite-wing radiography in detecting proximal caries and crestal bone loss The choice of gold standard for evaluating tests for caries diagnosis Intraoral versus extraoral bitewing radiography in detection of enamel proximal caries: an ex vivo study Ex vivo evaluation of new 2D and 3D dental radiographic technology for detecting caries Patient risk related to common dental radiographic examinations: the impact of 2007 International Commission on Radiological Protection recommendations regarding dose calculation Effective dose of dental CBCT -a meta analysis of published data and additional data for 9 CBCT units Clinical decision making and importance of AAOMR/AAE position statement for CBCT examination in endodontic cases Validity of micro-CT for in vitro caries detection: a systematic review and metaanalysis The effects of orthodontic materials on the accuracy of periapical radiography-based caries detection Diagnostic accuracy of different display types in detection of recurrent caries under restorations by using CBCT Precision of cone beam CT to assess periodontal bone defects: a systematic review and meta-analysis Periodontal disease Accuracy and usefulness of CBCT in periodontology: A systematic review of the literature Ex vivo comparison of CBCT and digital periapical radiographs for the quantitative assessment of periodontal defects Impact of CBCT on treatment decision related to surgical removal of impacted maxillary third molars: does CBCT change the surgical approach? Cone-beam computed tomography (CBCT) in the UBC Graduate Orthodontic Program International/American/Canadian Association of Dental Research. keywords: air; caries; cbct; control; covid-19; dental; disease; dpr; intraoral; pandemic; patients; radiography; use cache: cord-338900-8ojah695.txt plain text: cord-338900-8ojah695.txt item: #2480 of 2876 id: cord-338965-ewuqsfsf author: Alotaibi, Fawzia E. title: Emergence of carbapenem-resistant Enterobacteriaceae isolated from patients in a university hospital in Saudi Arabia. Epidemiology, clinical profiles and outcomes date: 2017-06-20 words: 5558 flesch: 42 summary: Introduction of OXA-48-producing Enterobacteriaceae to Israeli hospitals by medical tourism Country-to-country transfer of patients and the risk of multi-resistant bacterial infection Rapid spread of carbapenem resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium Novel carbapenem hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae Detection and spread of Escherichia coli possessing the plasmid-borne carbapenemase KPC-2 in Brooklyn Outcomes of carbapenemresistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality Outcome of carbapenem resistant Klebsiella pneumoniae bloodstream infections Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia Nosocomial outbreak of 487 VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 488 15: molecular basis, clinical risk factors, and outcome Carriage rate of carbapenem-resistant Klebsiella pneumoniae in hospitalised patients during a national outbreak Antimicrobial susceptibility patterns of KPC-producing or CTX-M-producing Enterobacteriaceae Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns Infection with panresistant Klebsiella pneumoniae: a report of 2 cases and a brief review of the literature Treatment options for infections caused by carbapenem-resistant Enterobacteriaceae: can we apply precision medicine to antimicrobial chemotherapy? Early detection of colonized cases allows appropriate implementation of contact precautions and prevents transmission to other patients and staff keywords: blood; carbapenem; carbapenemase; clinical; cre; cultures; days; hospital; infection; isolates; klebsiella; patients; pneumoniae cache: cord-338965-ewuqsfsf.txt plain text: cord-338965-ewuqsfsf.txt item: #2481 of 2876 id: cord-338968-b1gg2ha7 author: La Rosée, Felicitas title: Ruxolitinib in COVID-19 Hyperinflammation and Haematologic Malignancies date: 2020-08-20 words: 1091 flesch: 29 summary: Rojas and Sarmiento and a few other authors of anecdotic reports on patients with malignancies and COV-ID-19 provide meaningful insight on patients, who hardly entered clinical trials on COVID-19 protocols due to their malignant comorbidity [3] [4] [5] [6] In this issue of Acta Haematologica, Rojas and Sarmiento [4] from Chile report on 3 patients with progressive COVID-19 successfully treated with rux 10 mg b.i.d., thereby adding anecdotal evidence to the list of positive reports on rux in COVID-19 patients with moderate or severe disease. keywords: covid-19; dex; patients; treatment cache: cord-338968-b1gg2ha7.txt plain text: cord-338968-b1gg2ha7.txt item: #2482 of 2876 id: cord-339009-wcoch07b author: File, Thomas M. title: Severe Acute Respiratory Syndrome: Pertinent Clinical Characteristics and Therapy date: 2012-08-23 words: 6029 flesch: 43 summary: The majority of cases have been reported among healthcare providers and family members of SARS patients. All staff entering these infected and 13 infected healthcare providers who had documentrestricted areas follow strict and stepwise 'gowning' and 'degowned contacts with SARS patients (table V) . keywords: acute; cases; coronavirus; cov; days; disease; illness; onset; patients; sars; syndrome; transmission cache: cord-339009-wcoch07b.txt plain text: cord-339009-wcoch07b.txt item: #2483 of 2876 id: cord-339015-qn8wbnlw author: Kayingo, Gerald title: Bacteria and Viruses: The Bogeymen in the Intensive Care Unit date: 2019-03-06 words: 2381 flesch: 29 summary: P. aeruginosa is one of the leading causes of morbidity in ICU patients, especially those with VAP. It is also a common cause of ICU infections associated with devices and catheters, infections in the urinary tract, and surgical site infections. keywords: icu; infections; organisms; patients; sepsis; species; therapy cache: cord-339015-qn8wbnlw.txt plain text: cord-339015-qn8wbnlw.txt item: #2484 of 2876 id: cord-339021-mhdaov1f author: Hong, Kyung Soo title: Clinical Features and Outcomes of 98 Patients Hospitalized with SARS-CoV-2 Infection in Daegu, South Korea: A Brief Descriptive Study date: 2020-05-01 words: 2197 flesch: 49 summary: Levels of all proinflammatory cytokines were significantly higher in ICU patients. In our study, diabetes mellitus tended to be more common in ICU patients (23.1% vs. 7.1%, p=0.096). keywords: acute; care; clinical; icu; patients; study cache: cord-339021-mhdaov1f.txt plain text: cord-339021-mhdaov1f.txt item: #2485 of 2876 id: cord-339044-qy4jab37 author: Li, Man title: Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter Study date: 2020-08-25 words: 2593 flesch: 46 summary: In addition to age factors, we also found D-dimer levels >1,000 ng/L, and platelet counts < 125 × 10 9 /L on admission were associated with fatal outcomes in COVID-19 patients. (21) have reported that while COVID-19 patients with significantly elevated platelet count during treatment were on an average hospitalized longer, the platelet count at admission was lower in severely ill patients (169.67 ± 48.95) compared to those who were not severely ill (192.26 ± 58.12). keywords: covid-19; disease; factors; patients; risk; study; wuhan cache: cord-339044-qy4jab37.txt plain text: cord-339044-qy4jab37.txt item: #2486 of 2876 id: cord-339266-glmshsh6 author: Yin, R. title: Clinical characteristics of 106 patients with neurological diseases and co-morbid coronavirus disease 2019: a retrospective study date: 2020-05-05 words: 4584 flesch: 48 summary: [1] [2] [3] From December 2019 to 15 April 2020, the number of COVID-19 patients worldwide reached 2 million, and the mortality has exceeded 120,000. Novel Coronavirus (2019-nCoV) Situation Report-22 COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients First case of 2019 Novel Coronavirus Disease with Encephalitis A New Symptom of COVID-19: keywords: covid-19; diseases; group; license; patients; preprint; study cache: cord-339266-glmshsh6.txt plain text: cord-339266-glmshsh6.txt item: #2487 of 2876 id: cord-339267-p3djwg7v author: Taylor, Sally title: Exploring the experiences of patients, general practitioners and oncologists of prostate cancer follow-up: A qualitative interview study date: 2020-08-01 words: 5782 flesch: 55 summary: National Institute of Clinical Excellence (NICE) guidelines recommend that remote follow up should be considered for prostate cancer patients after at least 6 months of regular follow up (NICE, 2019); but they do not specify exactly what this should include and what is expected of primary care. NICE recommend that prostate cancer patients should have their PSA checked at least every 6 months for the first 2 years, and then at least once a year after that (NICE, 2019) but do not specify exactly when re-referral to their specialist teams should be take place. keywords: cancer; care; follow; patients; prostate; psa cache: cord-339267-p3djwg7v.txt plain text: cord-339267-p3djwg7v.txt item: #2488 of 2876 id: cord-339333-7tpnbr8q author: CHEN, YUXIAN title: Comparative serum proteome expression of the steroid-induced femoral head osteonecrosis in adults date: 2014-11-12 words: 3633 flesch: 44 summary: Serum protein samples prepared as described above were diluted 1:25 in Laemmli buffer and resolved by 10% SDS-PAGE (Invitrogen Life Technologies, Carlsbad, CA, USA). The differential expression of serum proteins from patients with SONFH and healthy volunteers was analyzed by the proteomics method. keywords: analysis; head; itih4; patients; protein; samples; serum; sonfh; study cache: cord-339333-7tpnbr8q.txt plain text: cord-339333-7tpnbr8q.txt item: #2489 of 2876 id: cord-339355-zkkj8a83 author: Siripanthong, Bhurint title: Coronavirus disease 2019 is delaying the diagnosis and management of chest pain, acute coronary syndromes, myocarditis and heart failure date: 2020-07-01 words: 2331 flesch: 22 summary: Furthermore, the way in which certain centers approach the diagnosis of ACS or myocardial infarction in COVID-19 patients may have contributed to the decline in the apparent incidence of ischemic heart disease. While there is some rationale to limiting troponin tests to COVID-19 patients with overt cardiac symptoms, especially in the setting of over-burdened clinical resources and the potential for unnecessary staff viral exposure, restricted cardiac enzyme testing could potentially miss true ACS and other cardiac pathology when relatively minor cardiac symptoms are overshadowed by more severe respiratory symptoms. keywords: acs; cardiac; covid-19; disease; elevation; infarction; patients cache: cord-339355-zkkj8a83.txt plain text: cord-339355-zkkj8a83.txt item: #2490 of 2876 id: cord-339406-81a7fkpj author: Borghi, M. O. title: Prevalence, specificity, and clinical association of anti-phospholipid antibodies in COVID-19 patients: are the antibodies really guilty? date: 2020-06-19 words: 3153 flesch: 51 summary: Importantly, aPL in COVID-19 patients are mainly reacting against β 2 -glycoprotein I (β 2 GPI) but display an epitope specificity different from antibodies found in APS patients. This data is in line with the unusual epitope specificity of anti-β 2 GPI antibodies documented in Figure 2 , supporting the hypothesis that aPL found in COVID-19 patients are different from aPL found in APS patients. keywords: anti; antibodies; apl; covid-19; patients; preprint cache: cord-339406-81a7fkpj.txt plain text: cord-339406-81a7fkpj.txt item: #2491 of 2876 id: cord-339436-0k73tlna author: Giagulli, Vito Angelo title: Worse progression of COVID‐19 in men: Is Testosterone a key factor? date: 2020-06-11 words: 7901 flesch: 32 summary: [116] These therapeutic aspects emphasized the concept that a blunted antibody response (particularly IgG) may precipitate a severe clinical course in COVID-19 patients. Circulation Endogenous sex hormones and the prospective association with cardiovascular disease and mortality in men: The Tromsø Study Cardiovascular Outcomes and All-cause Mortality Following Measurement of Endogenous Testosterone Levels Low serum testosterone and mortality in older men Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID-19 Thromboembolic risk and anticoagulant therapy in COVID-19 patients: Emerging evidence and call for action Venous thrombosis and arteriosclerosis obliterans of lower extremities in a very severe patient with 2019 novel coronavirus disease: a case report Effects of age, gender and menstrual cycle on platelet function assessed by impedance aggregometry Platelet activation status decreases after menopause Mean platelet volume in a patient with male hypogonadotropic hypogonadism: The relationship between low testosterone, metabolic syndrome, impaired fasting glucose and cardiovascular risk Endogenous testosterone, fibrinolysis, and coronary heart disease risk in hyperlipidemic men Relationship between sex hormones and haemostatic factors in healthy middle-aged men Coronavirus infections and immune responses SARS-CoV-2 and viral sepsis: observations and hypotheses Focus on Receptors for Coronaviruses with Special Reference to Angiotensin-converting Enzyme 2 as a Potential Drug Target -A Perspective. keywords: article; cells; cov-2; covid-19; hypogonadism; immune; levels; male; men; obesity; patients; prognosis; response; risk; sars; serum cache: cord-339436-0k73tlna.txt plain text: cord-339436-0k73tlna.txt item: #2492 of 2876 id: cord-339455-b8nu34vv author: Sakr, Yasser title: The clinical spectrum of pulmonary thromboembolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: A European case series date: 2020-09-25 words: 2412 flesch: 34 summary: The datasets used and analysed during the current report are available from the corresponding author on reasonable request Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography Antiphospholipid antibodies are not elevated in patients with severe COVID-19 pneumonia and venous thromboembolism Thrombotic risk in COVID-19: a case series and case-control study Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Diagnosing Pulmonary Thromboembolism in COVID-19: A Stepwise Clinical and Imaging Approach COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action SARS-2 Coronavirus-Associated Hemostatic Lung Abnormality in COVID-19: Is It Pulmonary Thrombosis or Pulmonary Embolism? Microthrombotic Complications of COVID-19 Are Likely Due to Embolism of Circulating Endothelial Derived Ultralarge Von Willebrand Factor (eULVWF) Decorated-Platelet Strings Endotheliitis and Endothelial Dysfunction in Patients with COVID-19: Its Role in Thrombosis and Adverse Outcomes High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Incidence of thrombotic complications in critically ill ICU patients with COVID-19 High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Pulmonary Embolism in Patients With COVID-19: Awareness of an Increased Prevalence Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2 Incidence of venous thromboembolism in hospitalized patients with COVID-19 Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past Systemic endothelial dysfunction: A common pathway for COVID-19, cardiovascular and metabolic diseases COVID-19 and haemostasis: a position paper from Italian Society on Thrombosis and Haemostasis (SISET) Acute Pulmonary Embolism in COVID-19 Patients on CT Angiography and Relationship to D-Dimer Levels Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study Pulmonary embolism in patients with COVID-19 pneumonia Thrombotic complications of patients admitted to intensive care with COVID-19 at a teaching hospital in the United Kingdom Enoxaparin 40 mg per Day Is Inadequate for Venous Thromboembolism Prophylaxis After Thoracic Surgical Procedure Efficacy and safety of highdose thromboprophylaxis in morbidly obese inpatients Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 keywords: associated; covid-19; hospital; patients; pte; therapy; thromboembolism cache: cord-339455-b8nu34vv.txt plain text: cord-339455-b8nu34vv.txt item: #2493 of 2876 id: cord-339467-ewqxf02j author: Liang, Ying title: Differential diagnosis of coronavirus disease 2019 from pneumonias caused by other etiologies in a fever clinic in Beijing date: 2020-10-20 words: 1556 flesch: 48 summary: Compared with non-COVID-19 patients, a higher proportion of COVID-19 patients had an identified epidemiological history (89.5% vs. 32.8%, P < 0.001). In non-COVID-19 patients, infiltrates on the CT scan mainly involved 1-2 lung lobes, while in COVID-19 patients, lesions involving 4-5 lobes were more common (COVID-19 vs. In this study, we found that epidemiological history was extremely important for identification of suspected cases of COVID-19 and for differential diagnosis. keywords: cases; covid-19; non; patients; study cache: cord-339467-ewqxf02j.txt plain text: cord-339467-ewqxf02j.txt item: #2494 of 2876 id: cord-339471-1510mzmy author: Ikizler, T. Alp title: COVID-19 in Dialysis Patients: Adding a Few More Pieces to the Puzzle date: 2020-05-08 words: 1714 flesch: 39 summary: There is prolonged positivity of pharyngeal swabs in MHD patients. These data highlight the importance of diligent oversight and care of MHD patients during COVID-19 pandemic. keywords: covid-19; disease; mhd; patients cache: cord-339471-1510mzmy.txt plain text: cord-339471-1510mzmy.txt item: #2495 of 2876 id: cord-339474-tsdq1rgz author: Rosen, Tony title: Managing Older Adults with Presumed COVID‐19 in the Emergency Department: A Rational Approach to Rationing date: 2020-07-13 words: 3279 flesch: 39 summary: In many EDs, pulmonary / critical care physicians, hospitalists, anesthesiologists, geriatricians, palliative care clinicians and other specialists have become more involved in ED patient care during this pandemic. The ED is often the first location where decisions about care for older adult patients with presumed or confirmed COVID-19 are made. keywords: age; care; decision; making; patients; providers; rationing cache: cord-339474-tsdq1rgz.txt plain text: cord-339474-tsdq1rgz.txt item: #2496 of 2876 id: cord-339504-8svo2w3u author: Lima, Rodrigo Moreira e title: Recommendations for local-regional anesthesia during the COVID-19 pandemic date: 2020-06-10 words: 2843 flesch: 33 summary: Regional anesthesia is not contra-indicated for COVID-19 positive patients. [24, 25] Anesthesia can be performed with routine care for COVID-19 negative patients who are not at risk. keywords: anesthesia; blocks; covid-19; disease; mask; patients; risk cache: cord-339504-8svo2w3u.txt plain text: cord-339504-8svo2w3u.txt item: #2497 of 2876 id: cord-339517-93nuovsj author: Consolo, Ugo title: Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio Emilia date: 2020-05-15 words: 5657 flesch: 46 summary: Section 3 was composed of questions investigating the impact of the COVID-19 outbreak on dental practice, which were the most common protective personal equipment (PPE) used before the COVID-19 outbreak and whether habitual PPE had been changed after the outbreak. We also investigated the association between the impact of COVID-19 on dental practice and level of concern about the professional future. keywords: anxiety; covid-19; dental; dentists; future; infection; pandemic; patients; survey cache: cord-339517-93nuovsj.txt plain text: cord-339517-93nuovsj.txt item: #2498 of 2876 id: cord-339568-th2xmhb6 author: Yan, Meitian title: Analysis of the diagnostic value of serum specific antibody testing for coronavirus disease 2019 date: 2020-06-27 words: 1870 flesch: 47 summary: sex, comorbidity status, symptoms, and severity of illness IgG antibody levels in compared groups varied as follows: significantly higher in males than females, 10.75 S/co(IQR23.79) and 6.82 S/co(IQR17.48), respectively; significantly higher in patients with comorbidity than patients without, 9.84 S/co(IQR23.53) and 6.58 S/co(IQR17.89), respectively; significantly higher in symptomatic patients than asymptomatic patients, 8 .48 S/co(IQR20.70) and 2.96 S/co(IQR12.48), respectively; significantly higher in the severe patient group than non-severe patient group, 11.05 S/co(IQR24.65) and 7.04 S/co(IQR18.50), respectively. On admission, the positive rate of IgG antibodies in non-severe patients was significantly higher than that in severe patients (p < 0.05). keywords: antibodies; coronavirus; igg; patients; sars cache: cord-339568-th2xmhb6.txt plain text: cord-339568-th2xmhb6.txt item: #2499 of 2876 id: cord-339589-dl2qpc0t author: Thachil, Jecko title: SARS-2 Coronavirus–Associated Hemostatic Lung Abnormality in COVID-19: Is It Pulmonary Thrombosis or Pulmonary Embolism? date: 2020-05-12 words: 2212 flesch: 33 summary: Since there is a crucial link between inflammation and thrombosis, more so in COVID-19 patients, are patients who are on immunosuppressants less likely to get severe pulmonary disease and complications? It is important to distinguish pulmonary microthrombi from pulmonary emboli in COVID-19 patients. keywords: covid-19; hemostasis; microthrombi; patients; pulmonary; thrombosis cache: cord-339589-dl2qpc0t.txt plain text: cord-339589-dl2qpc0t.txt item: #2500 of 2876 id: cord-339614-28s205p8 author: Dover, Jeffrey S. title: A Path to Resume Aesthetic Care: Executive Summary of Project AesCert Guidance Supplement—Practical Considerations for Aesthetic Medicine Professionals Supporting Clinic Preparedness in Response to the SARS-CoV-2 Outbreak date: 2020-05-01 words: 12539 flesch: 32 summary: Depending on the nature, duration and overall extent of the individual's activity in the office, including interactions with other patients, employees and others, the practice may need to consider further prophylactic measures up to and including temporary office closure, in order to minimize further exposure, ensure adequate site remediation, and assess the risk of further transmission. For all these reasons, consider limiting all such AGPs to one or more designated treatment rooms with appropriate air handling, containment and evacuation systems, in order to avoid exposing other treatment rooms or office areas. keywords: care; contact; covid-19; exposure; face; guidance; health; mask; office; patient; ppe; practice; procedures; risk; room; safety; staff; time; treatment; treatment room; use cache: cord-339614-28s205p8.txt plain text: cord-339614-28s205p8.txt item: #2501 of 2876 id: cord-339656-u0cpklsv author: de Groot-Mijnes, Jolanda D.F. title: Identification of New Pathogens in the Intraocular Fluid of Patients With Uveitis date: 2010-11-30 words: 4020 flesch: 40 summary: Of the human parechovirus–positive patients, 1 was immunocompromised and had panuveitis. To determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis. keywords: hsv; human; intraocular; patients; pcr; rubella; samples; uveitis; virus cache: cord-339656-u0cpklsv.txt plain text: cord-339656-u0cpklsv.txt item: #2502 of 2876 id: cord-339679-9hghy9pd author: Gurley, Emily S. title: Person-to-Person Transmission of Nipah Virus in a Bangladeshi Community date: 2007-07-17 words: 4026 flesch: 48 summary: No asymptomatic cases of Nipah virus infection were documented in contacts of Nipah virus patients who consented to provide a blood specimen (n = 20). We defi ned suspected case-patients with Nipah virus illness as persons with fever and altered mental status (serious illness) residing or working in the outbreak area or persons who had fever and cough or headache (mild illness) and who were contacts of patients with Nipah virus infection or resided in the outbreak area. keywords: case; confi; contact; illness; infection; nipah; outbreak; patient; person; transmission; virus cache: cord-339679-9hghy9pd.txt plain text: cord-339679-9hghy9pd.txt item: #2503 of 2876 id: cord-339686-oybnk1j8 author: Suassuna, José Hermógenes Rocco title: Technical note and clinical instructions for Acute Kidney Injury (AKI) in patients with Covid-19: Brazilian Society of Nephrology and Brazilian Association of Intensive Care Medicine date: 2020-08-26 words: 5774 flesch: 37 summary: These data did not suggest a higher incidence of AKI in patients with Covid-19 when compared to other patients with the same severity profile 17 . For this reason, there was an initial recommendation to restrict the entry of nephrologists and dialysis nurses in the cohorts allocated Covid-19 patients. keywords: acute; aki; care; cases; clinical; cov-2; covid-19; dialysis; injury; kidney; patients; renal; risk; rrt; sars cache: cord-339686-oybnk1j8.txt plain text: cord-339686-oybnk1j8.txt item: #2504 of 2876 id: cord-339695-3ij5pjjy author: Nopp, Stephan title: Risk of venous thromboembolism in patients with COVID‐19: A systematic review and meta‐analysis date: 2020-09-25 words: 4717 flesch: 36 summary: All rights reserved Pulmonary Embolism in COVID-19 Patients: Awareness of an Increased Prevalence Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Acute Pulmonary Embolism Associated with COVID-19 Pneumonia Detected by Pulmonary CT Angiography Venous Thromboembolism in Critically Ill Patients with Covid-19: Results of a Screening Study for Deep Vein Thrombosis Clinical Characteristics of Covid-19 in Remdesivir for the Treatment of Covid-19 -Preliminary Report Impact of anticoagulation prior to COVID-19 infection: a propensity score-matched cohort study Anakinra for severe forms of COVID-19: a cohort study Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 ( Therefore, the true underlying burden of VTE in COVID-19 patients is still not fully understood. keywords: analysis; covid-19; data; icu; patients; rates; risk; studies; study; vte cache: cord-339695-3ij5pjjy.txt plain text: cord-339695-3ij5pjjy.txt item: #2505 of 2876 id: cord-339705-x8l3zgfd author: Patil, Vijaykumar title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 words: 19197 flesch: 47 summary: International conference on communication and signal processing IEEE Dermatoglyphic characteristics of patients with rheumatoid arthritis Plantar and digital dermatoglyphic patterns in Malawian patients with diabetes, hypertension and diabetes with hypertension An approach for minutia extraction in latent fingerprint matching Fingerprint pattern examination of right hand thumb in relation to Blood Group Efficacy of fingerprint to determine gender and blood group Distribution of fingerprint patterns among medical students Dermatoglyphics study of fingerprints pattern's variations of a group of type II diabetic mellitus patients in erbil City Design and development of blood sample analyzer using intelligent machine vision techniques A study on relationship between dermatoglyphics and hypertension Detection of pre-diabetics by palmar prints: a computer study leading to a low-cost tool A case study on dermatoglyphics in rheumatoid arthritis Approaches to determination of a full profile of blood group genotypes: single nucleotide variant mapping and massively parallel sequencing Study of fingerprint patterns in type II diabetes mellitus Study of fingerprint patterns in type II diabetes mellitus Dermatoglyphics: an economical tool for prediction of diabetes mellitus A new method to assess asymmetry in fingerprints could be used as an early indicator of type 2 diabetes mellitus Study of fingerprint patterns in relation to gender and blood group Use of palmar dermatoglyphics in rheumatoid arthritis: a case-control study An automatic system to detect human blood group of many individuals in a parellel manner using image processing Application of dermatoglyphic traits for diagnosis of diabetic type 1 patients Spectrophotometric approach for automatic human blood typing Development of an automatic electronic system to human blood typing The study of dermatoglyphics in diabetics of North Coastal Andhra Pradesh population Pattern of fingerprints and their relation with blood groups Dermatoglyphics-quantitative analysis in rheumatoid arthritis Fingertip patterns: a diagnostic tool to predict diabetes mellitus An integrated fiberoptic-microfluidic device for agglutination detection and blood typing A study of fingerprints in relation to gender and blood group Finger ridge count and fingerprint pattern in maturity onset diabetes mellitus Determination and classification of blood types using image processing techniques Dermatoglyphics in rheumatoid arthritis Dermatoglyphics in rheumatoid arthritis Comparative study on the dermatoglyphic pattern among diabetic (type-2) and non-diabetic adults in North Indian population Dermatoglyphic patterns among type 2 diabetic adults in North Indian population Finger print pattern in different blood groups Forensic ABO blood grouping by 4 SNPs analyses using an ABI PRISMR 3100 genetic analyser Evaluation of ABO subtyping by DNA sequencing Finger dermatoglyphic patterns in diabetes mellitus Dermatoglyphics: a diagnostic tool to predict diabetes Utility of dermatoglyphics in Type II diabetes mellitus (T2DM) to assess the risk for IHD: Apilot study A study of dermatoglyphic pattern in relation to ABO, Rh blood group and gender among the population of Chhattisgarh Dermatoglyphics: blueprints of human cognition on fingerprints A cost-effective method for blood group detection using fingerprints Comparative study of the fingerprint pattern among diabetic (type 1) & non-diabetic children in Koya City Modis medical jurisprudence and toxicology Qualitative analysis of primary fingerprint pattern indifferent blood group and gender in Nepalese Study of dermatoglyphics in patients with type II diabetes mellitus essential hypertension in the age group between 35-55 Years International conference on automatic control and dynamic optimization techniques (ICAC-DOT). key: cord-339705-x8l3zgfd authors: Patil, Vijaykumar; Ingle, D. R. title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 journal: Artif Intell Rev DOI: 10.1007/s10462-020-09891-w sha: doc_id: 339705 cord_uid: x8l3zgfd In the current era of the digital world, the hash of any digital means considered as a footprint or fingerprint of any digital term but from the ancient era, human fingerprint considered as the most trustworthy criteria for identification and it also cannot be changed with time even up to the death of an individual. keywords: arches; blood; blood bunch; blood gathering; blood group; blood type; controls; diabetes; examination; females; fingerprint; fingerprint patterns; gathering; groups; guys; hand; hypertension; image; left; loops; mellitus; patients; patterns; ridge; right; type; whorls cache: cord-339705-x8l3zgfd.txt plain text: cord-339705-x8l3zgfd.txt item: #2506 of 2876 id: cord-339737-7qdjea6f author: Sbidian, E. title: Hydroxychloroquine with or without azithromycin and in-hospital mortality or discharge in patients hospitalized for COVID-19 infection: a cohort study of 4,642 in-patients in France date: 2020-06-19 words: 6053 flesch: 37 summary: For all IPT-weighting based analyses, standardized differences of the means were computed before and after IPTW to assess imbalance of the covariates between treatment groups. Table 2 shows unadjusted clinical outcomes by treatment group. keywords: azi; covid-19; day; discharge; drug; hcq; license; medrxiv; mortality; patients; preprint; treatment cache: cord-339737-7qdjea6f.txt plain text: cord-339737-7qdjea6f.txt item: #2507 of 2876 id: cord-339811-dms0rlmr author: Choudhury, Noura title: Training Oncologists in the Time of COVID‐19 date: 2020-06-05 words: 1494 flesch: 45 summary: In mid-March, to minimize the risk of asymptomatic carrier spread of infection to patients and preserve the workforce for potential inpatient redeployment, medical oncology fellows were asked to refrain from direct patient care in outpatient clinics and instead work remotely from home. When not redeployed, it may seem reasonable to allow fellows time for self-directed learning, rather than mandate inclusion into the new, virtual framework that represents our reality. keywords: cancer; care; new; time cache: cord-339811-dms0rlmr.txt plain text: cord-339811-dms0rlmr.txt item: #2508 of 2876 id: cord-339885-mpzgrogd author: Zhan, Yangqing title: Respiratory virus is a real pathogen in immunocompetent community-acquired pneumonia: comparing to influenza like illness and volunteer controls date: 2014-09-02 words: 3892 flesch: 42 summary: Compared with virus negative patients, sorethroat and fatigue was more common, leukocytosis and neutrophilia was less common in viral pneumonia patients, although fatigue and neutrophilia had no statistical significance. **Comparisons were made between virus positive patients and virus negative patients by non-parametric Kruskal-Wallis test for quantitative characteristics and Fisher's exact or Chi-square test for categorical variables, respectively. keywords: cap; community; infection; influenza; patients; pneumonia; study; virus cache: cord-339885-mpzgrogd.txt plain text: cord-339885-mpzgrogd.txt item: #2509 of 2876 id: cord-339913-ps4nvvaz author: Ma, Min title: How cardiologists respond to COVID-19: the experience of West China Hospital, China date: 2020-07-16 words: 1405 flesch: 35 summary: The intervention procedure for suspected patients with low risk in the emergency should be followed as usual. (II) High-risk suspected patients with viral infection should undergo a consultation by the on-duty physician in the catheterization room. While preventing COVID-19 and controlling its transmission, the diagnosis and treatment of patients with acute coronary syndrome (ACS) cannot be ignored. keywords: department; emergency; patients; room cache: cord-339913-ps4nvvaz.txt plain text: cord-339913-ps4nvvaz.txt item: #2510 of 2876 id: cord-339940-80757pwu author: Zaidi, S. Javed title: A novel approach to the diagnosis and treatment of hemoptysis in infants: A case series date: 2018-09-18 words: 2383 flesch: 35 summary: This case series focuses on infants, a small subset of hemoptysis patients, to underscore the importance of the presence of APCs in this cohort. Cardiac catheterization and coil embolization of aorto‐pulmonary collateral vessels (APCs) is uncommon in pediatric hemoptysis patients without congenital heart disease. keywords: apcs; cardiac; embolization; hemoptysis; patients cache: cord-339940-80757pwu.txt plain text: cord-339940-80757pwu.txt item: #2511 of 2876 id: cord-339956-o5o2yz1u author: Albahri, O.S. title: Helping Doctors Hasten COVID-19 Treatment: Towards a Rescue Framework for the Transfusion of Best Convalescent Plasma to the Most Critical Patients based on Biological Requirements via ML and Novel MCDM Methods date: 2020-06-20 words: 8697 flesch: 42 summary: Firstly, weights are assigned to the serological/protein biomarker and PaO 2 /FiO 2 criteria used in the prioritisation of CPs and COVID-19 patients. This stage aims to eliminate two critical issues (i.e. multi-criteria and trade-off issues) through ranking alternatives (i.e. CPs and/or COVID-19 patients). keywords: basis; blood; covid-19; cps; criteria; criterion; decision; evaluation; framework; matrix; mcdm; methods; multi; patients; plasma; prioritisation; protein cache: cord-339956-o5o2yz1u.txt plain text: cord-339956-o5o2yz1u.txt item: #2512 of 2876 id: cord-340000-1e66aqih author: Ho, Ivy K. title: The Role of Social Cognition in Medical Decision Making with Asian American Patients date: 2020-09-14 words: 4836 flesch: 34 summary: Drawing from research on medical decision making for Black American patients, we hypothesize that providers' perceptions of Asian Americans patients have implications for patient-provider interactions and communication and for treatment decisions. There are several reasons for these disparities, and one possible contributor is provider perceptions of Asian Americans, which in turn can affect their medical decision making when treating Asian American patients. keywords: americans; asian; healthcare; medical; minority; patients; providers; racial; stereotypes cache: cord-340000-1e66aqih.txt plain text: cord-340000-1e66aqih.txt item: #2513 of 2876 id: cord-340051-r9kn34wd author: MEI, Xue title: Observations about Symptomatic and Asymptomatic infections of 494 patients with COVID-19 in Shanghai,China date: 2020-07-06 words: 3228 flesch: 46 summary: METHODS: To retrospectively analyze the clinical data of 494 confirmed COVID-19 patients admitted to a designated hospital in Shanghai from January 20, 2020, to March 31, 2020, we compared the clinical manifestations in different populations and their influencing factors in COVID-19 patients. The majority of COVID-19 patients (91.7%) had early symptoms. keywords: acid; days; nucleic; patients; symptoms; test cache: cord-340051-r9kn34wd.txt plain text: cord-340051-r9kn34wd.txt item: #2514 of 2876 id: cord-340070-de7sfccy author: Pérez-Martinez, Antonio title: Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain date: 2020-08-29 words: 2307 flesch: 40 summary: Very little information is available about pediatric patients with underlying diseases, and data in children with immunosuppression is almost non-existent. Data from cancer pediatric patients is scarce. keywords: cases; children; covid-19; disease; patients cache: cord-340070-de7sfccy.txt plain text: cord-340070-de7sfccy.txt item: #2515 of 2876 id: cord-340164-vzdyy656 author: Karimi, Zohreh title: The Lived Experience of Nurses Caring for Patients with COVID-19 in Iran: A Phenomenological Study date: 2020-08-20 words: 3685 flesch: 51 summary: In addition to all the hardships and difficulties caused by heightened pressure in COVID-19 care centres, the fear of dying has become a challenge distracting nurses from genuine patient care; nurses have experienced being consumed by imagining the loss of life or the expectation of death causing them to distance themselves from care. Nurses need more support in the setting of COVID-19 care because nursing care practices are at serious risk. keywords: care; coronavirus; covid-19; nurses; participants; patients; study cache: cord-340164-vzdyy656.txt plain text: cord-340164-vzdyy656.txt item: #2516 of 2876 id: cord-340204-3gm58qza author: Mahmoodpoor, Ata title: Management of Critically Ill Patients with COVID-19: What We Learned and What We Do date: 2020-06-10 words: 1706 flesch: 43 summary: Almost five percent of COVID-19 patients require intensive care medicine admission, and most of them are complicated with acute respiratory distress syndrome (ARDS) There are some nonspecific therapeutic agents for COVID-19 patients, but the antiviral efficacy of these drugs is not yet known (2) . keywords: care; covid-19; management; patients; treatment cache: cord-340204-3gm58qza.txt plain text: cord-340204-3gm58qza.txt item: #2517 of 2876 id: cord-340232-cadu5ah8 author: Aliter, Kholoud F. title: Thrombin Inhibition by Argatroban: Potential Therapeutic Benefits in COVID-19 date: 2020-09-01 words: 5326 flesch: 31 summary: These effects provide a strong rationale for the use of thrombin inhibitors in treating COVID-19 patients. In this review, we describe the clinical features of COVID-19, the thrombin’s roles in various pathologies, and the potential of argatroban in COVID-19 patients. keywords: activation; argatroban; cells; coagulation; covid-19; drug; expression; factor; inflammation; patients; potential; thrombin; treatment; virus cache: cord-340232-cadu5ah8.txt plain text: cord-340232-cadu5ah8.txt item: #2518 of 2876 id: cord-340253-lpner9f8 author: D’Amario, Domenico title: Sex-Related Differences in Dilated Cardiomyopathy with a Focus on Cardiac Dysfunction in Oncology date: 2020-08-08 words: 5945 flesch: 28 summary: Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management Characteristics and survival of patients with chemotherapy-induced cardiomyopathy undergoing heart transplantation Management of end stage heart failure Myocardial expression of fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy Testosterone and interleukin-1β increase cardiac remodeling during coxsackievirus B3 myocarditis via serpin A 3n Age and gender effects on the extent of myocardial involvement in acute myocarditis: a cardiovascular magnetic resonance study Dilated cardiomyopathy Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy Cardiac myosin-Th17 responses promote heart failure in human myocarditis Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy Gonadectomy of male BALB/c mice increases Tim-3(+) alternatively activated M2 macrophages, Tim-3(+) T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis Sex differences in translocator protein 18 kDa (TSPO) in the heart: implications for imaging myocardial inflammation Mechanistic pathways of sex differences in cardiovascular disease IL-33 independently induces eosinophilic pericarditis and cardiac dilation: ST2 improves cardiac function Cardiovascular effects of androgenicanabolic steroids Effects of gonadectomy and hormonal replacement on rat hearts Gender differences in the cardiovascular effect of sex hormones Sex differences in the long-term prognosis of dilated cardiomyopathy Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy Prevalence and prognostic implications of longitudinal ejection fraction change in heart failure Acute heart failure twenty-nine years after treatment for childhood cancer Variations of circulating cardiac biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients Early increases in multiple biomarkers predict subsequent cardiotoxicity in patients with breast cancer treated with doxorubicin, taxanes, and trastuzumab Role of troponins I and T and N-terminal prohormone of brain natriuretic peptide in monitoring cardiac safety of patients with early-stage human epidermal growth factor receptor 2-positive breast cancer receiving trastuzumab: a Herceptin adjuvant study cardiac marker substudy Catestatin in acutely decompensated heart failure patients: insights from the CATSTAT-HF study Cardiovascular events in cancer survivors Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption Conflicting gender-related differences in the natural history of patients with idiopathic dilated cardiomyopathy Sex-and age-based differences in the natural history and outcome of dilated cardiomyopathy Barber G increased risk of cardiac dysfunction after anthracyclines in girls The article provide one of the first and most comprehensive description of prospective changes of echocardiographic variables in patients exposed to doxorubicin, highlighting the importance of sex for risk stratification A population-based study of cardiac morbidity among Hodgkin lymphoma patients with preexisting heart disease Clinical and preclinical evidence of sex-related differences in anthracycline-induced cardiotoxicity Predictive factors for severe toxicity of sunitinib in unselected patients with advanced renal cell cancer Risk of heart failure in breast cancer patients after anthracycline and trastuzumab treatment: a retrospective cohort study Cancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis Immune checkpoint inhibitor-related adverse cardiovascular events in patients with lung cancer Major cardiac events and the value of echocardiographic evaluation in patients receiving anthracycline-based chemotherapy Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition Cardiovascular effects of systemic cancer treatment Sex differences in cancer immunotherapy efficacy, biomarkers and therapeutic strategy Gender-related differences in heart failure: beyond the one-sizefits-all paradigm ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF) Are beta-blockers needed in patients receiving spironolactone for severe chronic heart failure? Cardio-oncology is a medical subspecialty dedicated to providing comprehensive CV care to cancer patients from cancer diagnosis to survivorship. keywords: cancer; cardiac; cardiomyopathy; dcm; differences; disease; dysfunction; failure; heart; patients; risk; sex; study; women cache: cord-340253-lpner9f8.txt plain text: cord-340253-lpner9f8.txt item: #2519 of 2876 id: cord-340314-5oz3013n author: Mazzitelli, Maria title: Use of subcutaneous tocilizumab in patients with COVID‐19 pneumonia date: 2020-05-15 words: 638 flesch: 44 summary: A single center experience First case of COVID-19 in a patient with multiple myeloma successfully treated with tocilizumab Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report COVID-19 in a patient with systemic sclerosis treated with tocilizumab for SSc-ILD Pharmacokinetic and Pharmacodynamic Analysis of Subcutaneous Tocilizumab in Patients With Rheumatoid Arthritis From 2 Randomized, Controlled Trials: SUMMACTA and BREVACTA New therapeutic opportunities for COVID-19 patients with Tocilizumab: Possible correlation of interleukin-6 receptor inhibitors with osteonecrosis of the jaws Letter to the Editor: Acute hypertriglyceridemia in patients with COVID-19 receiving tocilizumab We want to thank all our patients and our nurses. key: cord-340314-5oz3013n authors: Mazzitelli, Maria; Arrighi, Eugenio; Serapide, Francesca; Pelle, Maria Chiara; Tassone, Bruno; Lionello, Rosaria; Marrazzo, Giuseppina; Laganà, Domenico; Costanzo, Francesco Saverio; Matera, Giovanni; Trecarichi, Enrico Maria; Torti, Carlo title: Use of subcutaneous tocilizumab in patients with COVID‐19 pneumonia date: 2020-05-15 journal: J Med Virol DOI: 10.1002/jmv.26016 sha: doc_id: 340314 cord_uid: 5oz3013n Over the last months, pandemic SARS‐CoV‐2 caused a significant challenge for clinicians. keywords: covid-19; patients; tocilizumab cache: cord-340314-5oz3013n.txt plain text: cord-340314-5oz3013n.txt item: #2520 of 2876 id: cord-340383-psjga23p author: Simpson, Brenda Baird title: Patient Care Services Staffing Support During a Pandemic date: 2020-10-01 words: 2073 flesch: 46 summary: In addition to patients with the COVID-19 virus, there is a baseline of emergent patients that continue to need inpatient care for conditions such as trauma, stroke, and heart attack, particularly given the service Providing adequate patient care staffing during a pandemic requires creative teamwork. NGMC nursing care is led by nurses of all levels with respect for the expertise all nurses bring to the decision-making process. keywords: care; ngmc; nursing; pandemic; patient; staffing cache: cord-340383-psjga23p.txt plain text: cord-340383-psjga23p.txt item: #2521 of 2876 id: cord-340415-6fte7krp author: Thevarajan, Irani title: Clinical presentation and management of COVID‐19 date: 2020-07-17 words: 4292 flesch: 36 summary: The majority of patients presenting with coronavirus disease 2019 (COVID‐19) experience a mild illness that can usually be managed in the community. Patients require careful monitoring and early referral to hospital if any signs of clinical deterioration occur. keywords: care; covid-19; days; disease; hospital; infection; management; patients; sars; treatment cache: cord-340415-6fte7krp.txt plain text: cord-340415-6fte7krp.txt item: #2522 of 2876 id: cord-340430-x4oitcyh author: Horgan, T. J. title: Oral and Maxillofacial Surgery Patient Satisfaction with Telephone Consultations during the COVID-19 pandemic date: 2020-08-25 words: 2741 flesch: 48 summary: A high proportion of patients agreed that telephone consultations were as punctual as face to face, while 83.48% found telephone consultation to be as convenient. New patients reported lower levels of compliance which may suggest these consultations are less amenable to telephone consultation. keywords: consultations; patients; satisfaction; study; survey; telephone cache: cord-340430-x4oitcyh.txt plain text: cord-340430-x4oitcyh.txt item: #2523 of 2876 id: cord-340536-azlajqbe author: Bartolo, Michelangelo title: Urgent Measures for the Containment of the Coronavirus (Covid-19) Epidemic in the Neurorehabilitation/Rehabilitation Departments in the Phase of Maximum Expansion of the Epidemic date: 2020-04-30 words: 2658 flesch: 30 summary: Furthermore, in some areas due to the lack of beds, rehabilitation facilities are now being occupied with other patients, with consequent difficulty in hospitalizing patients, for example, discharged from stroke units. The following indications are suggested in order to make the reorganization of rehabilitation activities homogeneous, whether they are carried out in hospitalization or outpatient settings or at home, with the main aim of limiting patient flows within the facilities and maintaining staff safety. keywords: activities; care; cases; covid-19; epidemic; health; patients; rehabilitation cache: cord-340536-azlajqbe.txt plain text: cord-340536-azlajqbe.txt item: #2524 of 2876 id: cord-340542-jz7ca041 author: Lara Álvarez, Miguel Ángel title: Covid-19 mortality in cancer patients in a Madrid hospital during the first 3 weeks of the epidemic date: 2020-08-03 words: 1456 flesch: 43 summary: key: cord-340542-jz7ca041 authors: Lara Álvarez, Miguel Ángel; Revuelta, Jacobo Rogado; Portero, Berta Obispo; Méndez, Cristina Pangua; Montero, Gloria Serrano; Alfonso, Ana López title: Covid-19 mortality in cancer patients in a Madrid hospital during the first 3 weeks of the epidemic date: 2020-08-03 journal: Med Clin (Engl Ed) DOI: 10.1016/j.medcle.2020.05.012 sha: doc_id: 340542 cord_uid: jz7ca041 Abstract Background and objective The Covid-19 pandemic especially affects cancer patients with higher incidence and mortality according to published series of original pandemic foci. The study aims to determine the mortality in our center due to covid-19 in cancer patients during the first 3 weeks of the epidemic. keywords: cancer; covid-19; disease; patients cache: cord-340542-jz7ca041.txt plain text: cord-340542-jz7ca041.txt item: #2525 of 2876 id: cord-340576-dabcs3w5 author: Nishikawa, Hiroki title: Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis date: 2020-07-24 words: 8158 flesch: 36 summary: 2017 Gut Microbiota Dysbiosis in Patients With Non-Alcoholic Fatty Liver Disease Aberrant IgA Responses to the Gut Microbiota During Infancy Precede Asthma and Allergy Development Microbiota Transfer Therapy Alters Gut Ecosystem and Improves Gastrointestinal and Autism Symptoms: An Open-Label Study Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells Development of a Novel Frailty Index to Predict Mortality in Patients With End-Stage Liver Disease Combined Albumin-Bilirubin Grade and Skeletal Muscle Mass as a Predictor in Liver Cirrhosis Health-Related Quality of Life in Chronic Liver Diseases: A Strong Impact of Hand Grip Strength Resting Energy Expenditure and Nutritional State in Patients With Liver Cirrhosis before and after Liver Transplantation Frailty Associated With Waitlist Mortality Independent of Ascites and Hepatic Encephalopathy in a Multicenter Study Sarcopenia in cirrhosis: From pathogenesis to interventions Myosteatosis and Sarcopenia Are Associated With Hepatic Encephalopathy in Patients with Cirrhosis Reduced handgrip strength is predictive of poor survival among patients with liver cirrhosis: A sex-stratified analysis Prognostic significance of low skeletal muscle mass compared with protein-energy malnutrition in liver cirrhosis Review article: Malnutrition/sarcopenia and frailty in patients with cirrhosis Energy metabolism in patients with acute and chronic liver disease Clinical Significance of Therapy Using Branched-Chain Amino Acid Granules in Patients with Liver Cirrhosis and Hepatocellular Carcinoma Sarcopenia and cognitive impairment in liver cirrhosis: A viewpoint on the clinical impact of minimal hepatic encephalopathy Efficacy of Branched-Chain Amino Acid Supplementation and Walking Exercise for Preventing Sarcopenia in Patients with Liver Cirrhosis Supplementation with branched-chain amino acids ameliorates hypoalbuminemia, prevents sarcopenia, and reduces fat accumulation in the skeletal muscles of patients with liver cirrhosis Management of refractory ascites attenuates muscle mass reduction and improves survival in patients with decompensated cirrhosis Muscle atrophy as pre-sarcopenia in Japanese patients with chronic liver disease: Computed tomography is useful for evaluation The stratification of cirrhosis Slow walking speed overlapped with low handgrip strength in chronic liver disease patients with hepatocellular carcinoma Recommendation from the working group for creation of sarcopenia assessment criteria Growing research on sarcopenia in Asia Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. In addition, the energy metabolism of LC patients is in a hypercatabolic state, and when fasting early in the morning, they are in the same degree of starvation as when a healthy person fasts for 2-3 days keywords: bacteria; cirrhosis; disease; dysbiosis; encephalopathy; gut; hepatic; lc patients; liver; microbiota; muscle; patients; rifaximin; sarcopenia cache: cord-340576-dabcs3w5.txt plain text: cord-340576-dabcs3w5.txt item: #2526 of 2876 id: cord-340650-mwsa326c author: Elangovan, E. J. title: Rationale and prognosis of repurposed drugs with risk stratification of patients in oxygen support in COVID-19: A systematic review and meta-analysis date: 2020-10-06 words: 6406 flesch: 47 summary: [5.39-140.24 ]) of severe COVID-19 patients ( Figure 1 ). Vs. 37.5% STD) in viral load negativity within 72 hrs after CP transfusion in severe COVID-19 patients [44] . keywords: covid-19; license; medrxiv; mortality; patients; perpetuity; preprint; rate; studies; study; treatment cache: cord-340650-mwsa326c.txt plain text: cord-340650-mwsa326c.txt item: #2527 of 2876 id: cord-340651-g3518bq2 author: Hsu, Chung-Hua title: An Evaluation of the Additive Effect of Natural Herbal Medicine on SARS or SARS-like Infectious Diseases in 2003: A Randomized, Double-blind, and Controlled Pilot Study date: 2007-05-29 words: 3367 flesch: 56 summary: A 52-bed ward was rebuilt as negative pressure seclusion rooms to admit SARS patients. In fact, many anecdotal reports have been proposed on the use of NHM for SARS patients, unfortunately none was a controlled trial (20) . keywords: chest; day; diseases; nhm; patients; sars; study; syndrome; treatment cache: cord-340651-g3518bq2.txt plain text: cord-340651-g3518bq2.txt item: #2528 of 2876 id: cord-340660-ocvy1ge2 author: Mehmood, Maham A title: Methicillin-Resistant Staphylococcus Aureus: A Very Rare Cause of Meningitis date: 2020-09-10 words: 2113 flesch: 39 summary: High index of suspicion should be kept for physicians as bacterial meningitis is a medical emergency and if untreated, has a high mortality rate. After rigorous counselling, patient agreed for lumbar puncture (10 days into her illness) and the results were confirmatory for bacterial meningitis with gram stain positive for gram-positive cocci and bacterial antigen for Staphylococcus aureus (as seen in Table 1 ). keywords: aureus; blood; meningitis; mrsa; patient; therapy cache: cord-340660-ocvy1ge2.txt plain text: cord-340660-ocvy1ge2.txt item: #2529 of 2876 id: cord-340687-99ad1rwq author: Abourida, Yassamine title: Management of Severe COVID-19 in Pregnancy date: 2020-07-27 words: 2532 flesch: 41 summary: Information for healthcare professionals Analysis of vaginal delivery outcomes among pregnant women in Wuhan, China during the COVID-19 pandemic Estimation of the epidemic properties of the 2019 novel coronavirus: a mathematical modeling study The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients Pneumonia in pregnancy Organisation et prise en charge de la grossesse, de l'accouchement et du post-partum durant la période de pandémie COVID-19 Systematic review of hydroxychloroquine use in pregnant patients with autoimmune diseases Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France Hydroxychloroquine and azithromycin as a treatment of COVID-19: preliminary results of an open-label non-randomized clinical trial Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients Evidence for and against vertical transmission for severe acute respiratory syndrome coronavirus 2 Unlikely SARS-CoV-2 vertical transmission from mother to child: a case report Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn Severe COVID-19 during pregnancy and possible vertical transmission Coronavirus disease 2019 (COVID-19) pandemic and pregnancy Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Perinatal transmission of COVID-19 associated SARS-CoV-2: should we worry? Coronavirus disease 2019 in pregnant women: a report based on 116 cases Two cases of coronavirus 2019-related cardiomyopathy in pregnancy Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis Placental pathology in COVID-19 positive mothers: preliminary findings Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway Regulation of ferritin genes and protein COVID-19) infection in pregnancy. keywords: cov-2; covid-19; delivery; infection; pregnancy; sars; transmission cache: cord-340687-99ad1rwq.txt plain text: cord-340687-99ad1rwq.txt item: #2530 of 2876 id: cord-340710-dmow5p7k author: Lagana, Stephen M. title: Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data date: 2020-08-13 words: 4542 flesch: 45 summary: As the focus of this study is liver pathology, the lungs were considered only in the context of how the pulmonary findings may relate to liver injury. The role of immunosuppression and allograft recipient status on liver injury associated with COVID-19 will need further study. keywords: acute; cases; covid-19; hepatitis; injury; liver; patients; pcr; steatosis cache: cord-340710-dmow5p7k.txt plain text: cord-340710-dmow5p7k.txt item: #2531 of 2876 id: cord-340766-aic570x8 author: Kim, Se Jin title: Outcomes of Early Administration of Cidofovir in Non-Immunocompromised Patients with Severe Adenovirus Pneumonia date: 2015-04-15 words: 3634 flesch: 37 summary: We described the clinical characteristics and treatment outcomes of early cidofovir treatment of severe AdV pneumonia in non-immunocompromised patients. In the present study, we described favorable outcomes to antiviral therapy with cidofovir in non-immunocompromised adult patients with severe AdV pneumonia. keywords: adenovirus; adv; cidofovir; days; patients; pneumonia; study cache: cord-340766-aic570x8.txt plain text: cord-340766-aic570x8.txt item: #2532 of 2876 id: cord-340786-12vzsl6p author: Pinto, Susana title: New technologies and Amyotrophic Lateral Sclerosis – Which step forward rushed by the COVID-19 pandemic? date: 2020-08-05 words: 5245 flesch: 25 summary: The present work reviews the current technologies for ALS patients already in place or being under evaluation with published publications, prompted by the COVID-19 pandemic. Videoconferences connect the multidisciplinary ALS teams at the tertiary centres to the patients at home, or to the local community hospitals/ health centres (12, 21, 22) Two Australian tertiary hospitals established regular videoconferences with the local hospitals or community health services assisting ALS patients living far from the hospitals, thereby replacing the regular multidisciplinary in-clinic 3-mo consults (12) . keywords: als; care; clinic; data; disease; health; home; motor; patients; sclerosis; telemedicine cache: cord-340786-12vzsl6p.txt plain text: cord-340786-12vzsl6p.txt item: #2533 of 2876 id: cord-340799-1awmtj52 author: Krajewska, Joanna title: Review of practical recommendations for otolaryngologists and head and neck surgeons during the COVID-19 pandemic: Recommendations for otolaryngologists during the COVID-19 pandemic date: 2020-06-06 words: 7948 flesch: 41 summary: The estimated prevalence of cough in COVID-19 patients ranged between 60 and 82%, while the prevalence of dyspnea ranged between 9% and 37% [25] . Similarly, no recommendation for performing tracheotomy within 7 days in COVID-19 patients with ARDS has been proposed [47] . keywords: cases; cov-2; covid-19; head; individuals; infection; nasal; neck; pandemic; patients; procedures; risk; sars; surgery; tracheostomy; virus cache: cord-340799-1awmtj52.txt plain text: cord-340799-1awmtj52.txt item: #2534 of 2876 id: cord-340811-w4x4falm author: Frizzelli, Annalisa title: What happens to people’s lungs when they get coronavirus disease 2019? date: 2020-05-11 words: 1781 flesch: 37 summary: The levels of inflammatory cytokines (IL-1, TNF-α) are high in the lungs of COVID-19 patients and these cytokines are strong inducers of HA-synthase-2 (HAS2) in CD31+ endothelium, EpCAM+ lung alveolar epithelial cells, and fibroblasts (13) . Recent data suggest that COVID-19 patients who are hypoxemic respond well to PEEP, indicating a crucial role for NIV, as a therapeutic measure to prevent intubation (27) . keywords: coronavirus; covid-19; disease; novel; patients; pneumonia cache: cord-340811-w4x4falm.txt plain text: cord-340811-w4x4falm.txt item: #2535 of 2876 id: cord-340826-2530zdeq author: Hwang, Jong-moon title: Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study date: 2020-07-08 words: 2932 flesch: 47 summary: CONCLUSIONS: Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD. Regarding underlying diseases, we found that chronic lung disease and AD increase the mortality rate in COVID-19 patients. keywords: age; chronic; covid-19; disease; patients; study cache: cord-340826-2530zdeq.txt plain text: cord-340826-2530zdeq.txt item: #2536 of 2876 id: cord-340857-teq5txm9 author: Galloro, Giuseppe title: SAFETY IN DIGESTIVE ENDOSCOPY PROCEDURES IN THE COVID ERA RECOMMENDATIONS IN PROGRES OF THE ITALIAN SOCIETY OF DIGESTIVE ENDOSCOPY date: 2020-05-13 words: 3418 flesch: 38 summary: In addition the CDC and some other Authors detected the virus in the feces of CoViD-19 positive patients (in up to 54% of the cases), suggesting a potential fecal-oral transmission (31, 32) . A possible explanation could be that the first reports of new corona virus infection were correlated to the hospitalization of a high number of workers of the Huanan Seafood Wholesale Market, most of whom were male (13) . keywords: coronavirus; covid-19; digestive; disease; endoscopy; infection; patients; risk; symptoms cache: cord-340857-teq5txm9.txt plain text: cord-340857-teq5txm9.txt item: #2537 of 2876 id: cord-340880-2qop8tcp author: Hyman, Jaime B. title: Timing of Intubation and In-Hospital Mortality in Patients With Coronavirus Disease 2019 date: 2020-10-21 words: 3669 flesch: 34 summary: The challenge for clinicians is to determine which hypoxemic COVID-19 patients are at greatest risk of further respiratory decompensation in order to optimize timing of intubation and initiation of mechanical ventilation, without intubating patients who could have done well on noninvasive ventilation. In this large, multihospital, retrospective cohort study of COVID-19 positive patients who underwent mechanical ventilation during the peak of the COVID-19 pandemic in New York City, we found that timing of intubation had a small but significant association with improved survival. keywords: admission; hospital; intubation; mortality; patients; time; ventilation cache: cord-340880-2qop8tcp.txt plain text: cord-340880-2qop8tcp.txt item: #2538 of 2876 id: cord-340908-8q7i5ds3 author: D’Ambrosi, Riccardo title: Guidelines for Resuming Elective Hip and Knee Surgical Activity Following the COVID-19 Pandemic: An Italian Perspective date: 2020-10-13 words: 1843 flesch: 40 summary: People Who Are at Increased Risk for Severe Illness Surgery in COVID-19 patients: operational directives Personal protective equipment during the COVID-19 pandemic -a narrative review Ten Weeks to Crush the Curve How to analyze the Visual Analogue Scale: Myths, truths and clinical relevance COVID-19 coronavirus: recommended personal protective equipment for the orthopaedic and trauma surgeon Adding Examples to the ASA-Physical Status Classification Improves Correct Assignment to Patients Characteristics of SARS-CoV-2 patients dying in Italy: Report based on available data on Practical considerations for performing regional anesthesia: lessonslearned from the COVID-19 pandemic Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis Safe Selection of Outpatient Joint Arthroplasty Patients With Medical Risk Stratification: the Outpatient Arthroplasty Risk Assessment Score Developing a standardized approach to virtual clinic follow-up of hip and knee arthroplasty Risk factors of critical and mortal COVID-19 cases: A systematic literature review and meta-analysis key: cord-340908-8q7i5ds3 authors: D’Ambrosi, Riccardo; Biazzo, Alessio; Masia, Francesco; Izzo, Vincenzo; Confalonieri, Norberto; Ursino, Nicola; Verde, Francesco title: Guidelines for Resuming Elective Hip and Knee Surgical Activity Following the COVID-19 Pandemic: An Italian Perspective date: 2020-10-13 journal: HSS J DOI: 10.1007/s11420-020-09809-w sha: doc_id: 340908 cord_uid: 8q7i5ds3 nan At our institution in Italy, we developed a protocol to establish treatment recommendations for patients with orthopedic pathology who needed surgery during the COVID-19 pandemic. keywords: cov-2; covid-19; patients; risk; surgery cache: cord-340908-8q7i5ds3.txt plain text: cord-340908-8q7i5ds3.txt item: #2539 of 2876 id: cord-340984-blkhfhe2 author: Gklinos, Panagiotis title: Neurological manifestations of COVID-19: a review of what we know so far date: 2020-05-26 words: 2677 flesch: 41 summary: The above-mentioned clinical case series in Wuhan, China, showed that 36.4% of COVID-19 patients had neurological symptoms at onset. Continuing documentation of neurological symptoms and signs, timely CSF testing, EEG, and brain autopsies of COVID-19 patients who did not survive may help us understand better the neurological manifestations of the novel coronavirus as well as the pathophysiological mechanisms of CNS involvement. keywords: coronavirus; cov-2; covid-19; patients; sars; symptoms cache: cord-340984-blkhfhe2.txt plain text: cord-340984-blkhfhe2.txt item: #2540 of 2876 id: cord-341063-3rqnu5bu author: None title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 words: 98736 flesch: 48 summary: Since altered liver function has also been described in ICU patients without sepsis [1, 2] , the influence of sepsis may be overestimated. The aim of this work is to analyze the connection between serum and fecal levels of AMM in ICU patients. keywords: acute; admission; adult patients; age; aim; aki; analysis; ards; arrest; assessment; baseline; blood; brain; cardiac; care; care patients; care unit; cases; changes; clinical; cohort; complications; conclusions; control; correlation; criteria; critical; data; day mortality; days; decrease; diagnosis; difference; discharge; duration; dysfunction; early; effect; emergency; end; factors; failure; fig; flow; fluid; following; group; hospital; hospital mortality; hours; icu admission; icu mortality; icu patients; icu stay; impact; incidence; increase; infection; injury; introduction; length; levels; lung; mean; median; medical; methods; min; model; months; mortality; non; organ; outcome; p<0.001; parameters; patients; period; population; post; pressure; protocol; rate; renal; results; risk; risk patients; score; sepsis; septic; severity; shock; significant; sofa; stay; studies; study; support; surgery; surgery patients; survival; survivors; table; test; therapy; time; total; transfusion; treatment; unit; use; value; ventilation; volume; years cache: cord-341063-3rqnu5bu.txt plain text: cord-341063-3rqnu5bu.txt item: #2541 of 2876 id: cord-341076-ox2ckhqu author: Cenzato, Marco title: Editorial. Neurosurgery in the storm of COVID-19: suggestions from the Lombardy region, Italy (ex malo bonum) date: 2020-04-10 words: 1263 flesch: 40 summary: In our albeit preliminary experience, opening the hospital doors to neurosurgeons coming from other institutions has offered an unprecedented opportunity of collaboration and integration of teams, which will ultimately serve as a model not only to cope with catastrophic events but also to establish a basis for a higher level of rationalization of neurosurgical patient care. Since about 10% of COVID-19 patients require admission to the ICU due to serious respiratory insufficiency, it soon became evident before the pandemic that the number of available ICU beds within the region (a total of 720) was by far not enough. keywords: cases; hub; patients; region cache: cord-341076-ox2ckhqu.txt plain text: cord-341076-ox2ckhqu.txt item: #2542 of 2876 id: cord-341118-h5t87vf8 author: Torres‐Navarro, Ignacio title: A case of cefditoren‐induced Acute Generalized Exanthematous Pustulosis during COVID‐19 pandemics. Severe Cutaneous Adverse Reactions (SCARs) are an issue date: 2020-05-26 words: 631 flesch: 48 summary: All rights reserved Cutaneous manifestations in COVID-19: a first perspective Acute generalized exanthematous pustulosis (AGEP)--a clinical reaction pattern Recent advances in the understanding of severe cutaneous adverse reactions Acute generalized exanthematous pustulosis: a case series of 13 patients in Brazil Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection Acknowledgments: The patient in this manuscript has given written informed consent to the publication of her case details. All rights reserved Dear editor, We read with interest the article by Recalcati et al. about the report of cutaneous manifestations in COVID-19 patients. keywords: article; copyright cache: cord-341118-h5t87vf8.txt plain text: cord-341118-h5t87vf8.txt item: #2543 of 2876 id: cord-341197-e8m4oxma author: Soleimani, Abbas title: Effects of angiotensin receptor blockers (ARBs) on in-hospital outcomes of patients with hypertension and confirmed or clinically suspected COVID-19 date: 2020-09-12 words: 3649 flesch: 43 summary: After adjustment for the same confounders in the whole cohort and hypertensive patients, Cox proportional hazard models (Figure 1 and Supplementary We observed no significant difference between female and male patients, either in the whole cohort or hypertensive patients, in terms of in-hospital outcomes; however, female hypertensive patients were more likely to incur ARDS rather than male hypertensive patients (P=0.014) (Supplementary Table 4 ). [15] [16] nevertheless, some studies suggest that ACEI/ARBs were associated with improved outcomes in COVID-19 patients. keywords: aki; arbs; covid-19; disease; hospital; hypertensive; outcomes; patients cache: cord-341197-e8m4oxma.txt plain text: cord-341197-e8m4oxma.txt item: #2544 of 2876 id: cord-341202-1pg7rq2d author: Manicone, Francesca title: The last bed dilemma burns out COVID-19 triage: a viewpoint from Medical and Law students date: 2020-08-12 words: 1322 flesch: 46 summary: In our view, this solution would suitably respond to two essential problems: a patient otherwise discarded by the guidelines might be given a chance to survive based on physician clinical experience whereas, if nonetheless the meeting withheld the bed, the physician would relieve his stress, sharing, to the greatest extent possible, the burden with the team. As its etymology suggests, trier means the culling, the sorting and allocation of patients, treatments or resources, historically attempted by a plethora of methods. keywords: care; covid-19; health; patient cache: cord-341202-1pg7rq2d.txt plain text: cord-341202-1pg7rq2d.txt item: #2545 of 2876 id: cord-341234-2zgfcrwc author: Hallak, Jorge title: Concise practice recommendations for the provision of andrological services and assisted reproductive technology for male infertility patients during the SARS-CoV-2 in Brazil date: 2020-09-02 words: 3616 flesch: 33 summary: key: cord-341234-2zgfcrwc authors: Hallak, Jorge; Esteves, Sandro C. title: Concise practice recommendations for the provision of andrological services and assisted reproductive technology for male infertility patients during the SARS-CoV-2 in Brazil date: 2020-09-02 journal: Int Braz J Urol DOI: 10.1590/s1677-5538.ibju.2020.06.03 sha: doc_id: 341234 cord_uid: 2zgfcrwc nan The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS--CoV-2), responsible for the disease so-called CO-VID-19, represents the most exceptional health, social, economic, and humanitarian crisis known to humankind since the H1N1 flu of 1918. SARS-CoV-2 pandemic and repercussions for male infertility patients: A proposal for the individualized provision of andrological services Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. keywords: care; cov-2; infertility; men; pandemic; patients; sars; semen; sperm cache: cord-341234-2zgfcrwc.txt plain text: cord-341234-2zgfcrwc.txt item: #2546 of 2876 id: cord-341284-jmqdnart author: Panagopoulos, Periklis title: Lopinavir/ritonavir as a third agent in the antiviral regimen for SARS-CoV-2 infection date: 2020-06-12 words: 1553 flesch: 49 summary: Lymphocytes were more significantly increased in patients of group A. Ferritin serum levels were also decreased significantly in these patients. New treatment options for patients with severe symptoms and ways of reducing transmission in the community are taken into consideration. keywords: group; lopinavir; patients; ritonavir cache: cord-341284-jmqdnart.txt plain text: cord-341284-jmqdnart.txt item: #2547 of 2876 id: cord-341314-1mav631s author: Caso, Valeria title: No lockdown for neurological diseases during COVID19 pandemic infection date: 2020-04-08 words: 1706 flesch: 36 summary: At the end of the procedure, the patient is transferred to the Infectious Disease ward or a dedicated Intensive Care Unit (ICU) dedicated to COVID-19 patients based on neurological conditions. Baracchini et al., in this brief report published in this current issue, are sharing how the University Hospital of Padua, with a catchment area of about 950.000 people, structured a pathway for acute stroke patients before admitting them to our Stroke Unit [9] . keywords: care; covid-19; patients; stroke; unit cache: cord-341314-1mav631s.txt plain text: cord-341314-1mav631s.txt item: #2548 of 2876 id: cord-341359-c34gyuv6 author: Larson, Derek T title: Clinical Outcomes of Coronavirus Disease 2019 With Evidence-based Supportive Care date: 2020-05-30 words: 1206 flesch: 35 summary: Notes A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical features and short-term outcomes of 221 patients with COVID-19 in Wuhan Effectiveness of convalescent plasma therapy in severe COVID-19 patients An epidemiological study on COVID-19: a rapidly spreading disease Characteristics of COVID-19 infection in Beijing The risks of prescribing hydroxychloroquine for treatment of COVID-19-first, do no harm Covid-19-a reminder to reason Acknowledgments. We believe this is attributable to multiple factors, including a focus on supportive care that is well established to benefit patients and a conservative intubation strategy. keywords: care; covid-19; disease; patients cache: cord-341359-c34gyuv6.txt plain text: cord-341359-c34gyuv6.txt item: #2549 of 2876 id: cord-341415-g781zhu6 author: Jhaveri, Kenar D. title: Thrombotic microangiopathy in a patient with COVID-19 date: 2020-06-07 words: 1006 flesch: 43 summary: Due to worsening hypoxemia, patient received convalescent plasma treatment as part of an expanded access trial. AKI is not uncommon in patients with COVID-19 (8) . keywords: complement; covid-19; kidney; patient cache: cord-341415-g781zhu6.txt plain text: cord-341415-g781zhu6.txt item: #2550 of 2876 id: cord-341531-w788qwya author: Montero Feijoo, A. title: Practical recommendations for the perioperative management of patients with suspicion or serious infection by coronavirus SARS-CoV date: 2020-05-04 words: 3720 flesch: 39 summary: key: cord-341531-w788qwya authors: Montero Feijoo, A.; Maseda, E.; Adalia Bartolomé, R.; Aguilar, G.; González de Castro, R.; Gómez-Herreras, J. I.; García Palenciano, C.; Pereira, J.; Ramasco Rueda, F.; Samso, E.; Suárez de la Rica, A.; Tamayo Medel, G.; Varela Durán, M. title: Practical recommendations for the perioperative management of patients with suspicion or serious infection by coronavirus SARS-CoV date: 2020-05-04 journal: nan DOI: 10.1016/j.redare.2020.03.002 sha: doc_id: 341531 cord_uid: w788qwya Abstract In December 2019, the Wuhan Municipal Health and health Commission (Hubei Province, China) reported a series of cases of pneumonia of unknown aetiology. The vast majority of these viruses cause mild upper respiratory tract infections in immunocompetent adults, and can cause more severe symptoms in patients with risk factors. keywords: cases; cov-2; mask; operating; patients; ppe; room; sars cache: cord-341531-w788qwya.txt plain text: cord-341531-w788qwya.txt item: #2551 of 2876 id: cord-341591-ib8lsvku author: Simpson, J. Keith title: Informed consent, duty of disclosure and chiropractic: where are we? date: 2020-11-04 words: 8922 flesch: 41 summary: In this way, CCEs indirectly influence patient care and safety through their role of ensuring the standards of training delivered by chiropractic educational institutions [70] . The chiropractic research community reviewed the ICA reports and found they provided no valid clinical scientific evidence that chiropractic care can impact the immune system [16] . keywords: care; chiropractic; consent; disclosure; duty; health; information; law; patient; physician; practitioner; professional; subluxation cache: cord-341591-ib8lsvku.txt plain text: cord-341591-ib8lsvku.txt item: #2552 of 2876 id: cord-341627-21m8rdhy author: Buda, Natalia title: Lung ultrasound in the diagnosis of COVID-19 infection - A case series and review of the literature date: 2020-06-25 words: 2486 flesch: 41 summary: key: cord-341627-21m8rdhy authors: Buda, Natalia; Segura-Grau, Elena; Cylwik, Jolanta; Wełnicki, Marcin title: Lung ultrasound in the diagnosis of COVID-19 infection - Lung ultrasound (LUS) is a dynamically developing diagnostic method used in intensive care, cardiology and nephrology, it can also be helpful in diagnosing and monitoring pneumonia. keywords: coronavirus; covid-19; diagnosis; examination; lung; patients; ultrasound cache: cord-341627-21m8rdhy.txt plain text: cord-341627-21m8rdhy.txt item: #2553 of 2876 id: cord-341670-o1v63zg8 author: Estevez-Ordonez, Dagoberto title: Letter: Perioperative and Critical Care Management of a Patient With Severe Acute Respiratory Syndrome Corona Virus 2 Infection and Aneurysmal Subarachnoid Hemorrhage date: 2020-05-20 words: 889 flesch: 43 summary: Postoperative CT angiogram of the head showed appropriate clip reconstruction with no compromise of M2 MCA branches. She was discharged home on postoperative day 6 with a modified Rankin scale of 1. 12 keywords: coronavirus; cov-2; patient; sars cache: cord-341670-o1v63zg8.txt plain text: cord-341670-o1v63zg8.txt item: #2554 of 2876 id: cord-341919-8gnthufw author: Basi, Saajan title: Clinical course of a 66-year-old man with an acute ischaemic stroke in the setting of a COVID-19 infection date: 2020-08-23 words: 4197 flesch: 45 summary: As of April 2020, no comprehensive data of the relationship between ischaemic stroke and COVID-19 has been published, however early retrospective case series from three hospitals in Wuhan, China have indicated that up to 36% of COVID-19 patients had neurological manifestations, including stroke. 13 Other hypothesised reasons for stroke development in COVID-19 patients are the development of hypercoagulability, as a result of critical illness or new onset of arrhythmias, caused by severe infection. keywords: admission; care; covid-19; oxygen; patient; pneumonia; sars; stroke cache: cord-341919-8gnthufw.txt plain text: cord-341919-8gnthufw.txt item: #2555 of 2876 id: cord-341933-dwki1hwu author: Jeong, Han-Gil title: Therapeutic Temperature Modulation for a Critically Ill Patient with COVID-19 date: 2020-06-03 words: 1082 flesch: 40 summary: Considering extracorporeal membrane oxygenation (ECMO) as the last resort, we applied therapeutic temperature modulation for management of hyperpyrexia. Therapeutic temperature modulation may have successfully offloaded the failing cardiorespiratory system from metabolic cost and hyperinflammation induced by hyperpyrexia. keywords: day; patient; syndrome; temperature cache: cord-341933-dwki1hwu.txt plain text: cord-341933-dwki1hwu.txt item: #2556 of 2876 id: cord-341999-nosdj7b2 author: Conti, A. title: Evolution of COVID‐19 infection in 4 psoriatic patients treated with biological drugs date: 2020-05-07 words: 604 flesch: 32 summary: However, few reports are available on the course of COVID-19 infection in psoriatic patients treated with biological drugs (2) . key: cord-341999-nosdj7b2 authors: Conti, A.; Lasagni, C.; Bigi, L.; Pellacani, G. title: Evolution of COVID‐19 infection in 4 psoriatic patients treated with biological drugs date: 2020-05-07 journal: J Eur Acad Dermatol Venereol DOI: 10.1111/jdv.16587 sha: doc_id: 341999 cord_uid: nosdj7b2 Since December 2019, the pandemic coronavirus disease (2019‐nCoV; COVID‐19) has changed the approach to all dermatological diseases; in particular, psoriatic patients undergoing immunosuppressive drugs, such as biologics, can potentially show an increase risk of infection (1). keywords: infection; patients cache: cord-341999-nosdj7b2.txt plain text: cord-341999-nosdj7b2.txt item: #2557 of 2876 id: cord-342068-zhk3wmou author: Khazanie, Prateeti title: Forced Choices: Ethical Challenges in Cardiology During the COVID-19 Pandemic date: 2020-05-11 words: 1342 flesch: 37 summary: During the 2009 H1N1 pandemic the Institute of Medicine developed a crisis standards of care (CSC) framework 3 for ethically allocating resources in times of scarcity, which is now adapted for possible use in critical care resource triage in the COVID-19 pandemic. Implementing critical care triage under CSC must happen acutely and without long-term relationships. keywords: cardiologists; care; patients; triage cache: cord-342068-zhk3wmou.txt plain text: cord-342068-zhk3wmou.txt item: #2558 of 2876 id: cord-342139-t2tukk0z author: Livingston, Gill title: Prevalence, management, and outcomes of SARS-CoV-2 infections in older people and those with dementia in mental health wards in London, UK: a retrospective observational study date: 2020-10-05 words: 6642 flesch: 50 summary: Implementation of the long-standing policy of parity of esteem for mental health so that resources are as available to mental health patients is urgently needed. In some Trusts, resources to protect mental health patients and staff were unavailable at the time they became available for those admitted locally with physical illness, with patients in intensive care units being tested from March 3, 2020, 32 and symptomatic patients in general hospital wards being tested before March 28, 2020. keywords: care; cov-2; covid-19; dementia; health; mental; patients; people; sars; study; trusts cache: cord-342139-t2tukk0z.txt plain text: cord-342139-t2tukk0z.txt item: #2559 of 2876 id: cord-342246-tnjtd9n3 author: Özçelik Korkmaz, Müge title: Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection date: 2020-10-03 words: 4427 flesch: 48 summary: Hyposmia can generally be caused by upper respiratory tract infections; however, these symptoms can be present in COVID-19 patients without any nasal symptoms, suggesting the direct viral damage to the chemosensory system [9] . These datas suggest that otological and vestibular symptoms should also be questioned in COVID-19 patients. keywords: clinical; covid-19; patients; smell; study; symptoms; taste; terms cache: cord-342246-tnjtd9n3.txt plain text: cord-342246-tnjtd9n3.txt item: #2560 of 2876 id: cord-342303-ddulfe06 author: Ismael, Julia title: Multidisciplinary approach to COVID-19 and cancer: consensus from scientific societies in Argentina date: 2020-05-13 words: 7129 flesch: 39 summary: Cancer patients are a very special population in this setting since they are more susceptible to viral infections than the general population. To review the evidence available in order to create a multi-institutional position from the perspective of scientific societies in Argentina involved in the management of cancer patients. keywords: cancer; cancer patients; care; cases; covid-19; health; infection; palliative; pandemic; panel; patients; recommendations; risk; therapy; treatment cache: cord-342303-ddulfe06.txt plain text: cord-342303-ddulfe06.txt item: #2561 of 2876 id: cord-342451-yfy5jcw6 author: Rigamonti, Andrea title: Cerebral venous thrombosis associated with coronavirus infection: an underestimated entity? date: 2020-06-29 words: 813 flesch: 41 summary: Prominent changes in blood coagulation of patients with SARS-CoV-2 infection Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action Neurologic manifestations of hospitalized patients with coronavirus disease Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations More specifically, Ddimer, fibrinogen and fibrinogen degradation product are significantly increased, whereas AT III levels are lower in COVID-19 patients compared with a healthy control population [3] . keywords: covid-19; patients; thrombosis cache: cord-342451-yfy5jcw6.txt plain text: cord-342451-yfy5jcw6.txt item: #2562 of 2876 id: cord-342519-tjr6dvtt author: Souza, Thiago Moreno L. title: H1N1pdm Influenza Infection in Hospitalized Cancer Patients: Clinical Evolution and Viral Analysis date: 2010-11-30 words: 5170 flesch: 42 summary: Because the analysis of this novel viral infection in cancer patients is an important component of the 2009 pandemics, we conducted a prospective cohort study aimed at evaluating the clinical course of influenza infection, the duration of viral shedding, H1N1pdm evolution and the emergence of antiviral resistance in hospitalized cancer patients with a severe H1N1pdm infection in a reference cancer center during the winter of 2009 in Brazil. Prolonged influenza A H1N1pdm shedding was observed in cancer patients. keywords: cancer; days; h1n1pdm; infection; influenza; oseltamivir; pandemic; patients; shedding; table; virus cache: cord-342519-tjr6dvtt.txt plain text: cord-342519-tjr6dvtt.txt item: #2563 of 2876 id: cord-342555-5r9aa7u5 author: Eghtesadi, Marzieh title: Breaking Social Isolation Amidst COVID‐19: A Viewpoint on Improving Access to Technology in Long‐Term Care Facilities date: 2020-04-24 words: 1607 flesch: 35 summary: For older patients isolated in LTC facilities, providing them with these technology-dependent amenities and social contacts could potentially decrease their sense of loneliness and increase their self-perceived health, similarly to the benefits seen with physically going outdoors. In addition to the known risks to older adults and those with chronic conditions, we are already seeing evidence that people with lower socioeconomic status are disproportionally affected by this virus 4, 5 (higher burden of chronic medical conditions leading to higher risk of morbidity and mortality; less ability overall to socially distance leading to higher risk of infection; less financial cushioning leading to worse financial distress, etc). keywords: care; health; pandemic; patients cache: cord-342555-5r9aa7u5.txt plain text: cord-342555-5r9aa7u5.txt item: #2564 of 2876 id: cord-342569-ja96xfns author: Azer, Samy A. title: COVID-19: Pathophysiology, diagnosis, complications and Investigational therapeutics date: 2020-08-05 words: 2672 flesch: 39 summary: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias Liver injury during highly pathogenic human coronavirus infections Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features Clinical characteristics of 3,062 COVID-19 patients: a metaanalysis Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea Laboratory diagnosis of emerging human coronavirus infections -the state of the art Sensitive and specific monoclonal antibody-based capture enzyme immunoassay for detection of nucleocapsid antigen in sera from patients with severe acute respiratory syndrome Whole body point of care ultrasound for COVID-19: a multisystem approach to a multi-system disease A diagnostic model for coronavirus disease 2019 (COVID-19) based on radiological semantic and clinical features: a multi-center study Epidemiological and initial clinical characteristics of patients with family aggregation of COVID-19 The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients A geroscience perspective on COVID-19 mortality Panton-Valentine Leukocidin-Secreting Staphylococcus aureus Approximately 5% of COVID-19 patients require to be admitted to intensive care unit because they develop severe disease complicated with acute respiratory distress syndrome keywords: acute; coronavirus; cov-2; covid-19; disease; infection; patients; protein; sars cache: cord-342569-ja96xfns.txt plain text: cord-342569-ja96xfns.txt item: #2565 of 2876 id: cord-342603-k0f33p3l author: Spyropoulos, Alex C. title: Scientific and Standardization Committee Communication: Clinical Guidance on the Diagnosis, Prevention and Treatment of Venous Thromboembolism in Hospitalized Patients with COVID‐19 date: 2020-05-27 words: 3805 flesch: 22 summary: Initial data support a high incidence of thromboembolic disease, and especially VTE, in hospitalized COVID-19 patients, as well as poorer outcomes for COVID-19 patients with pre-existing cardiovascular disease [3, 7] . Early reports suggest a high incidence of VTE in hospitalized COVID-19 patients, particularly those with severe illness, that is similar to the high VTE rates observed in patients with other viral pneumonias, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS-CoV) keywords: article; covid-19; lmwh; management; patients; risk; thromboprophylaxis; vte cache: cord-342603-k0f33p3l.txt plain text: cord-342603-k0f33p3l.txt item: #2566 of 2876 id: cord-342786-dl8vjwfn author: Sattar, Yasar title: COVID-19 Cardiovascular Epidemiology, Cellular Pathogenesis, Clinical Manifestations and Management date: 2020-07-14 words: 5274 flesch: 32 summary: A study reports that heart failure is a common manifestation of COVID-19 patients, seen in 23% of affected patients [47] . Hypertension is frequently seen in COVID-19 patients however it is unclear whether it is a risk factor for acquiring COVID-19. keywords: angiotensin; cardiac; coronavirus; cov-2; covid-19; disease; dysfunction; infection; patients; receptor; risk; sars; syndrome cache: cord-342786-dl8vjwfn.txt plain text: cord-342786-dl8vjwfn.txt item: #2567 of 2876 id: cord-342808-yonbowkb author: Francque, Sven title: Innovative liver research continues during the current pandemic date: 2020-05-24 words: 2009 flesch: 30 summary: Patients with advanced liver disease as well as liver transplant patients likely represent vulnerable patient cohorts with an increased risk of infection and/or a severe course of COVID-19. Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable covalently closed circular DNA Stopping nucleos(t)ide analogue treatment in Caucasian hepatitis B patients after HBeAg seroconversion is associated with high relapse rates and fatal outcomes Treating chronic hepatitis delta: the need for surrogate markers of treatment efficacy TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection PPARa gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis Combined alcoholic and non-alcoholic steatohepatitis Health-related quality of life and patient-reported outcome measures in NASH-related cirrhosis Features and outcome of AIH patients without elevation of IgG Liver transplantation for late-onset presentations of acute liver failure in Wilson's disease: the UK experience over 2 decades Hepatobiliary MR contrast agents are useful to diagnose hepatocellular carcinoma in patients with Budd-Chiari syndrome Evaluation of liver tumour response by imaging keywords: disease; hepatitis; liver; patients; treatment cache: cord-342808-yonbowkb.txt plain text: cord-342808-yonbowkb.txt item: #2568 of 2876 id: cord-342809-wrxejwms author: Song, Jungeun title: Characteristics of First Visit Pediatric Patients with Suicidal Ideation and Behavior: An 8-Year Retrospective Chart Review date: 2020-10-01 words: 4172 flesch: 43 summary: Among male patients, the ratio of patients increased gradually from elementary to middle to high school levels. *p＜0.05 ually from elementary to middle to high school levels. keywords: group; health; patients; problems; school; study; suicide cache: cord-342809-wrxejwms.txt plain text: cord-342809-wrxejwms.txt item: #2569 of 2876 id: cord-342810-41dghl0c author: Nguyen, Thanh N. title: Subarachnoid hemorrhage guidance in the era of the COVID-19 pandemic -An opinion to mitigate exposure and conserve personal protective equipment date: 2020-06-05 words: 3909 flesch: 34 summary: In patients in whom aneurysm securing is delayed for unavoidable reasons, empiric use of prothrombotic agents such as aminocaproic acid or tranexamic acid should be avoided due to the presumptive increased risk of disseminated intravascular coagulation or pro-thrombotic conditions in COVID-19 patients. Maintain euvolemia during the aneurysm procedure but take care to avoid hypervolemia / overresuscitation given the risk of pulmonary complications in COVID-19 patients may be worsened by excessive fluid intake. keywords: care; clinical; covid-19; hemorrhage; pandemic; patients; ppe; procedure; risk; room; sah cache: cord-342810-41dghl0c.txt plain text: cord-342810-41dghl0c.txt item: #2570 of 2876 id: cord-342841-b1rucgmg author: Di Carlo, Francesco title: Telepsychiatry and other cutting edge technologies in Covid‐19 pandemic: bridging the distance in mental health assistance date: 2020-09-18 words: 5261 flesch: 38 summary: Considering the experiences from past serious virus pandemics, improvement of mental health care are needed [69] . Accepted Article Mental Health, Risk Factors, and Social Media Use During the COVID-19 Epidemic and Cordon Sanitaire Among the Community and Health Professionals in Wuhan, China: Cross-Sectional Survey Mental health consequences during the initial stage of the 2020 Coronavirus pandemic (COVID-19) in Spain Epidemic of COVID-19 in China and associated Psychological Problems Patients with mental health disorders in the COVID-19 epidemic Preventing problematic internet use during the COVID-19 pandemic: Consensus guidance Problematic Internet use (PIU), personality profiles and emotion dysregulation in a cohort of young adults: trajectories from risky behaviors to addiction Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) Mental Health Response to the COVID-19 Outbreak in China Global mental health and COVID-19. keywords: article; care; copyright; covid-19; health; pandemic; patients; review; services; treatment; use cache: cord-342841-b1rucgmg.txt plain text: cord-342841-b1rucgmg.txt item: #2571 of 2876 id: cord-342857-vj6sw2ne author: McCullough, Peter A. title: Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection date: 2020-08-07 words: 2216 flesch: 24 summary: As with azithromycin, doxycycline has the Because ambulatory centers and clinics have been reticent to have face-to-face visits for COVID-19 patients, telemedicine is a reasonable platform for monitoring. A randomized, double-blind, placebo-controlled trial Can Zn Be a Critical Element in COVID-19 Treatment? Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19 Risk Factors for Mortality in Patients with COVID-19 in Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology Macrolides and viral infections: focus on azithromycin in COVID-19 pathology Outcomes of 3,737 COVID-19 patients treated with hydroxychloroquine/azithromycin and other regimens in Marseille, France: A retrospective analysis Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France Early Outpatient Treatment of Symptomatic Patients that Should be Ramped-Up Immediately as Key to the Pandemic Crisis Clinical failure with and without empiric atypical bacteria coverage in hospitalized adults with community-acquired pneumonia: a systematic review and meta-analysis Doxycycline as a potential partner of COVID-19 therapies Therapeutic Potential for Tetracyclines in the Treatment of COVID-19Pharmacotherapy 2020 Doxycycline Is a Costeffective Therapy for Hospitalized Patients With Community-Acquired Pneumonia an antiviral for COVID-19 A review of the safety of favipiravir -a keywords: coronavirus; covid-19; disease; patients; sars; therapy; treatment cache: cord-342857-vj6sw2ne.txt plain text: cord-342857-vj6sw2ne.txt item: #2572 of 2876 id: cord-342930-f7cw2ca6 author: Portincasa, Piero title: Hepatic consequences of COVID-19 infection. Lapping or biting? date: 2020-06-01 words: 3018 flesch: 39 summary: This is particularly true if patients are older or have a pre-existing history of liver diseases. The mechanisms and strategies to protect from hepatic ischemia-32 reperfusion injury Liver -guardian, modifier and target of sepsis Specific ACE2 expression in cholangiocytes may 39 cause liver damage after 2019-nCoV infection Ischaemia reperfusion injury in liver 41 transplantation: Cellular and molecular mechanisms Immune responses in COVID-19 and potential vaccines: 1 Lessons learned from SARS and MERS epidemic Pathogen recognition and Toll-like receptor targeted therapeutics in innate 3 immune cells Infection of neonatal 5 mice with sindbis virus results in a systemic inflammatory response syndrome Systemic viral infections and collateral damage in the liver Evolution of the immune system in humans from infancy 10 to old age MCP-1 Expression in an Autocrine Manner in Hepatocytes during Acute Mouse Liver Injury signaling axis is a key mediator of hepatic ischemia-reperfusion injury Mitochondrial 17 oxidative injury in rat fatty livers exposed to warm ischemia-reperfusion The reduced 20 tolerance of rat fatty liver to ischemia reperfusion is associated with mitochondrial oxidative injury People who are at higher risk for severe illness Study of the relationship SARS and hepatitis virus B Care of patients 26 with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper The global burden of liver disease: the major 29 impact of China Prevention of SARS-CoV-2 infection in patients with 31 decompensated cirrhosis Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population 34 Utilizing Ultrasound and Liver Biopsy: A Prospective Study Systematic review: the epidemiology and natural history of 36 non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults Prevalence of 39 nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition 40 Examination Survey Changes in the prevalence 1 of the most common causes of chronic liver diseases in the United States from Exercising the hepatobiliary-gut axis. keywords: coronavirus; covid-19; damage; disease; infection; injury; liver; patients; study cache: cord-342930-f7cw2ca6.txt plain text: cord-342930-f7cw2ca6.txt item: #2573 of 2876 id: cord-342979-pvewvmmf author: Martínez-del Río, Jorge title: Comparative analysis between the use of renin-angiotensin system antagonists and clinical outcomes of hospitalized patients with COVID-19 respiratory infection date: 2020-11-12 words: 4399 flesch: 45 summary: Methods This is an observational study of 921 consecutive patients admitted with COVID-19 respiratory infection to Hospital General Universitario Ciudad Real from March 1 to April 30, 2020. Conclusions RAS inhibitor treatment prior to admission in patients with COVID-19 respiratory infection was associated with lower risk of the primary composite endpoint and did not show neither impact on mortality nor need for invasive mechanical ventilation, even if these drugs were prescribed during hospitalization. keywords: acei; arbs; infection; patients; risk; study cache: cord-342979-pvewvmmf.txt plain text: cord-342979-pvewvmmf.txt item: #2574 of 2876 id: cord-343023-e1uv7t6p author: Zhang, Jingchen title: Failure of early extubation among cases of coronavirus disease-19 respiratory failure: Case report and clinical experience date: 2020-07-02 words: 1712 flesch: 43 summary: The First Affiliated Hospital Covid-19 in critically Ill patients in the seattle region -case series Predicting success of high-flow nasal cannula in pneumonia patients with hypoxemic respiratory failure: the utility of the ROX index Clinical characteristics of coronavirus disease 2019 in China Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China A weaning protocol administered by critical care nurses for the weaning of patients from mechanical ventilation Editor: Maya Saranathan. [1] Relevant clinical manifestations included long course of disease, rapid progression of respiratory failure among critical patients, of whom most required mechanical ventilation (MV) for life support. keywords: disease; extubation; patients cache: cord-343023-e1uv7t6p.txt plain text: cord-343023-e1uv7t6p.txt item: #2575 of 2876 id: cord-343052-dc9s2rau author: Murgo, Salvatore title: Haemoptysis treated by bronchial artery embolisation in severe acute respiratory syndrome coronavirus 2: case report date: 2020-09-05 words: 1876 flesch: 41 summary: Baseline laboratory values showed a slightly prolonged activated partial thromboplastin time (APTT) and increased D-dimer level which have both been reported in COVID-19 patients and associated with poor prognosis (Tang et al. 2020) . The lungs are the target organ for SARS-CoV-2, and progressive respiratory failure is the primary cause of death in COVID-19 patients. keywords: covid-19; embolisation; haemoptysis; patient cache: cord-343052-dc9s2rau.txt plain text: cord-343052-dc9s2rau.txt item: #2576 of 2876 id: cord-343201-98scxky8 author: Thibault, Ronan title: How the Covid-19 epidemic is challenging our practice in clinical nutrition—feedback from the field date: 2020-09-16 words: 5825 flesch: 36 summary: In an analysis of data from the Hong Kong cohort of patients and a meta-analysis, authors found that 17.6% of Covid-19 patients had GI symptoms and virus RNA fragments were detected in stool samples from 48.1% patient, even in stools collected after respiratory samples became negative [15] . Challenge 8-clinical situations and organizational constraints that may make EN unfeasible need to be known There are obvious clinical situations and organizational constraints increasing the risk of EN complications and the constraints related to NGT and EN are probably higher in Covid-19 patients than in standard medical patients: Issue 1-despite the absence of data in Covid-19 patients, the risk of EN complications may be higher in patients requiring high outflow oxygen Many patients are still receiving high flow nasal cannula therapy or noninvasive ventilation in many centers keywords: care; clinical; covid-19; epidemic; hospital; malnutrition; ngt; nutrition; patients; risk; support cache: cord-343201-98scxky8.txt plain text: cord-343201-98scxky8.txt item: #2577 of 2876 id: cord-343205-zjw4fbfd author: Bhaskar, Sonu title: Telemedicine as the New Outpatient Clinic Gone Digital: Position Paper From the Pandemic Health System REsilience PROGRAM (REPROGRAM) International Consortium (Part 2) date: 2020-09-07 words: 9177 flesch: 25 summary: A randomized controlled trial using high-fidelity simulation Self-management maintenance inhalation therapy with eHealth (SELFIE): observational study on the use of an electronic monitoring device in respiratory patient care and research Telemedicine in primary care for patients with chronic conditions: the ValCrònic Quasi-Experimental study Impact of telemonitoring home care patients with heart failure or chronic lung disease from primary care on healthcare resource use (the TELBIL study randomised controlled trial) Home-based telemonitoring of simple vital signs to reduce hospitalization in heart failure patients: real-world data from a community-based hospital Home telemonitoring of non-invasive ventilation decreases healthcare utilisation in a prospective controlled trial of patients with amyotrophic lateral sclerosis Adjusted cost analysis of video televisits for the care of people with amyotrophic lateral sclerosis Telehealth exercise-based cardiac rehabilitation: a systematic review and meta-analysis Feasibility and acceptability of inpatient palliative care E-family meetings during COVID-19 pandemic Telemedically augmented palliative care: Such patients are also at high risk of infection and poor outcomes, including mortality, among COVID-19-positive patients (3) . keywords: access; care; covid-19; disease; health; healthcare; heart; issues; management; monitoring; pandemic; patients; physician; rehabilitation; review; risk; stroke; systems; technologies; telehealth; telemedicine; use cache: cord-343205-zjw4fbfd.txt plain text: cord-343205-zjw4fbfd.txt item: #2578 of 2876 id: cord-343308-5i31ysee author: Liu, Juan title: Detection of SARS‐CoV‐2 by RT‐PCR in anal from patients who have recovered from coronavirus disease 2019 date: 2020-04-14 words: 359 flesch: 51 summary: A Potential Shedding Rout Molecular and serological investigation of2019-nCoV infected patients: implication of multiple shedding routes Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China. key: cord-343308-5i31ysee authors: Liu, Juan; Xiao, Yong; Shen, Yuan; Shi, Chao; Chen, Yujun; Shi, Ping; Gao, Yumeng; Wang, Yiqing; Lu, Bin title: Detection of SARS‐CoV‐2 by RT‐PCR in anal from patients who have recovered from coronavirus disease 2019 date: 2020-04-14 journal: J Med Virol DOI: 10.1002/jmv.25875 sha: doc_id: 343308 cord_uid: 5i31ysee keywords: coronavirus; patients cache: cord-343308-5i31ysee.txt plain text: cord-343308-5i31ysee.txt item: #2579 of 2876 id: cord-343393-8hdygwip author: Kudsi, Omar Yusef title: Robotic Low Anterior Resection for a Distal Sigmoid Colon Cancer during the COVID‐19 Pandemic – a Video Vignette date: 2020-08-13 words: 351 flesch: 42 summary: Laparoscopic vs. open total mesorectal excision in unselected patients with rectal cancer: impact on early outcome Sages and eaes recommendations regarding surgical response to covid-19 crisis How to manage smoke evacuation and filter pneumoperitoneum during laparoscopy to minimize potential viral spread: different methods from SoMe Coronavirus pandemic and Colorectal surgery: practical advice based on the Italian experience Accepted Article Colorectal Dis DOI: 10.1111/codi.15310 sha: doc_id: 343393 cord_uid: 8hdygwip The COVID‐19 pandemic brings unprecedented challenges for both surgeons and patients. keywords: pandemic; patients cache: cord-343393-8hdygwip.txt plain text: cord-343393-8hdygwip.txt item: #2580 of 2876 id: cord-343437-cz1w9od9 author: Kahaly, George J title: Management of Graves‘Thyroidal And Extrathyroidal Disease – An Update date: 2020-09-14 words: 6264 flesch: 17 summary: Endocrine practice : official journal of the American College of Endocrinology and the Sensitivity, specificity, and cost-effectiveness of the sensitive thyrotropin assay in the diagnosis of thyroid disease in ambulatory patients Applications of a new chemiluminometric thyrotropin assay to subnormal measurement European survey of clinical practice patterns in the management of Graves' disease TSH receptor autoantibody immunoassay in patients with Graves' disease: improvement of diagnostic accuracy over different generations of methods. Archives of internal medicine Analysis of 754 cases of antithyroid druginduced agranulocytosis over 30 years in Japan Antithyroid-drug-induced agranulocytosis complicated by life-threatening infections Graves' disease is more frequent with an initial dose of 30 mg daily than with 15 mg daily Agranulocytosis induced by propylthiouracil: evidence of a drug dependent antibody reacting with granulocytes, monocytes and haematopoietic progenitor cells Drug-induced neutropenia associated with antineutrophil cytoplasmic antibodies (ANCA): possible involvement of complement in granulocyte cytotoxicity Current understanding of the mechanisms of idiosyncratic druginduced agranulocytosis Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study Genetic variants associated with antithyroid druginduced agranulocytosis: a genome-wide association study in a European population Clinical presentation and management of drug-induced agranulocytosis Antineutrophil Cytoplasmic Antibody-Positive Small-Vessel Vasculitis Associated with Antithyroid Drug Therapy: How Significant Is the Clinical Problem? Endocrine practice : official journal of the American College of Endocrinology and the Analysis of 90 cases of antithyroid drug-induced severe hepatotoxicity over 13 years in China Antithyroid drug-related hepatotoxicity in hyperthyroidism patients: a population-based cohort study Clinical associations between thyroid and liver diseases Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum Maternal hyperthyroidism and congenital malformation in the offspring Maternal and perinatal outcome in thyrotoxicosis complicating pregnancy Maternal Thyroid Function in Early Pregnancy and Child Neurodevelopmental Disorders: A Danish Nationwide Case-Cohort Study Therapy of endocrine disease: antithyroid drug use in early pregnancy and birth defects: time windows of relative safety and high risk? keywords: antithyroid; disease; drug; graves; hyperthyroidism; orbitopathy; patients; receptor; risk; study; therapy; thyroid; treatment; tsh cache: cord-343437-cz1w9od9.txt plain text: cord-343437-cz1w9od9.txt item: #2581 of 2876 id: cord-343443-ljehete1 author: Kissling, Sébastien title: Collapsing glomerulopathy in a COVID-19 patient. date: 2020-04-15 words: 890 flesch: 36 summary: However, the exact mechanisms underlying renal injury in patients with COVID-19 are unclear as renal pathology data are lacking. Kidney disease is associated with in-hospital death of patients with COVID-19 Clinical Characteristics of 138 Hospitalized Patients With Novel Coronavirus-Infected Pneumonia in Wuhan, China A Novel Coronavirus from Patients with Pneumonia in China HIV-associated nephropathies: epidemiology, pathology, mechanisms and treatment Acute cytomegalovirus infection complicated by collapsing glomerulopathy Parvovirus-B19-associated complications in renal transplant recipients HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes Should COVID-19 Concern Nephrologists? keywords: acute; covid-19; patient cache: cord-343443-ljehete1.txt plain text: cord-343443-ljehete1.txt item: #2582 of 2876 id: cord-343452-4m0ub9iv author: Barkama, Ravit title: Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019 date: 2020-09-15 words: 4254 flesch: 40 summary: The majority of COVID-19 patients suffering from ARDS require invasive mechanical ventilation. Similar to other reports on MSCs (32), PLX-PAD is negative for both ACE2 and TMPRSS2; therefore, it can be safely used in COVID-19 patients without being a further target for SARS-CoV-2. PLX-PAD was administered via intramuscular injection. keywords: cells; covid-19; data; days; disease; mesenchymal; pad; patients; plx; stromal; treatment cache: cord-343452-4m0ub9iv.txt plain text: cord-343452-4m0ub9iv.txt item: #2583 of 2876 id: cord-343490-94vkfrtw author: Handaya, Adeodatus Yuda title: Covid-19 mimicking symptoms in emergency gastrointestinal surgery cases during pandemic: a case series date: 2020-10-24 words: 1407 flesch: 45 summary: All patients need to be examined for COVID-19, including in digestive surgery emergency cases. The COVID-19 pandemic has changed the ways patients are admitted and treated, including in emergency digestive surgery cases. keywords: case; covid-19; emergency; patient; surgery cache: cord-343490-94vkfrtw.txt plain text: cord-343490-94vkfrtw.txt item: #2584 of 2876 id: cord-343566-epvswt7f author: Wang, Zhao-Hua title: Critically Ill Patients with Coronavirus Disease 2019 in a Designated ICU: Clinical Features and Predictors for Mortality date: 2020-07-20 words: 3295 flesch: 47 summary: Several previous descriptive cohort studies have reported epidemiological, demographic, and clinical characteristics of COVID-19 patients, as well as severe cases. SARS-CoV-2 could also cause myocardial injury, as assessed by increased troponin I level accompanying increased cardiovascular symptoms in COVID-19 patients. keywords: covid-19; data; hospital; mortality; patients; sars; sofa; study; survivors cache: cord-343566-epvswt7f.txt plain text: cord-343566-epvswt7f.txt item: #2585 of 2876 id: cord-343715-y594iewi author: Gavriatopoulou, Maria title: Organ-specific manifestations of COVID-19 infection date: 2020-07-27 words: 8776 flesch: 34 summary: Cerebrovascular disease represents another mechanism explaining neurological signs and symptoms in COVID-19 patients, although the rate of acute stroke admissions has been significantly reduced over the COVID-19 pandemic [125] . Among COVID-19 patients who suffered a stroke, the rate of cryptogenic and embolic strokes was higher, and events were more severe and affected younger patients [126, 129] . keywords: ace2; acute; cells; china; coronavirus; cov-2; covid-19; disease; infection; injury; manifestations; patients; pneumonia; sars; study; symptoms; syndrome cache: cord-343715-y594iewi.txt plain text: cord-343715-y594iewi.txt item: #2586 of 2876 id: cord-343743-6k3soh1l author: Chaudhary, Sachin title: Antifibrotics in COVID-19 Lung Disease: Let Us Stay Focused date: 2020-09-09 words: 3353 flesch: 34 summary: Health Qual Life Outcomes Correlation between pneumonia severity and pulmonary complications in middle east respiratory syndrome Follow-up chest radiographic findings in patients with MERS-CoV after recovery Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection -clinicopathological and ultrastructural study The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors The longterm impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study Pathology and pathogenesis of severe acute respiratory syndrome Abnormal pulmonary function in COVID-19 patients at time of hospital discharge Clinical features of patients infected with 2019 novel coronavirus in Wuhan COVID-19 pneumonia: different respiratory treatments for different phenotypes? Now, months since the initial description in Wuhan, China, with almost 10 million infected worldwide and about half a million deaths, the clinical and the scientific communities have learned much and pivoted to high-quality evidence for the management of COVID-19 patients. keywords: ards; covid-19; fibrosis; lung; patients; pulmonary; survivors; syndrome cache: cord-343743-6k3soh1l.txt plain text: cord-343743-6k3soh1l.txt item: #2587 of 2876 id: cord-343773-9f7ew8uj author: Volo, T. title: Elective tracheostomy during COVID-19 outbreak: to whom, when, how? Early experience from Venice, Italy date: 2020-07-12 words: 3626 flesch: 47 summary: The need for prolonged invasive mechanical ventilation in COVID-19 patients is placing the otorhinolaryngologist in front of an increasing request for tracheostomy. The mortality rate of COVID-19 patients admitted to ICU that underwent tracheostomy was 18%. keywords: covid-19; days; dimer; patients; risk; sofa; study; tracheostomy cache: cord-343773-9f7ew8uj.txt plain text: cord-343773-9f7ew8uj.txt item: #2588 of 2876 id: cord-343797-kpmz5kwg author: Lee, Martin Beng‐Huat title: GOING TO WAR ON COVID19: MOBILIZING AN ACADEMIC NEPHROLOGY GROUP PRACTICE date: 2020-07-04 words: 2877 flesch: 40 summary: Doctors could also be re-deployed to the emergency department and hospital pandemic ward teams to care for COVID-19 patients. In ICU, continuous renal replacement therapy (CRRT) and sustained low efficiency dialysis (SLED) for COVID-19 patients was performed using dedicated machines. keywords: care; covid-19; dialysis; disease; hospital; nephrology; patients cache: cord-343797-kpmz5kwg.txt plain text: cord-343797-kpmz5kwg.txt item: #2589 of 2876 id: cord-343819-1uki4b3d author: Mian, Muhammad S title: Pathological Findings and Management of COVID-19 Patients: A Brief Overview of Modern-day Pandemic date: 2020-05-15 words: 4661 flesch: 46 summary: Two drugs, remdesevir and chloroquine, have shown some good results, but it is too soon to state their efficacy as there is limited data on the effectiveness of these drugs in COVID-19 patients. In this review article, we aim to identify and highlight clinical features, pathological and radiological findings, and possible treatment options for COVID-19 patients and to organize the little information we have on this pathogen. keywords: coronavirus; covid-19; disease; findings; patients; pneumonia; symptoms; treatment cache: cord-343819-1uki4b3d.txt plain text: cord-343819-1uki4b3d.txt item: #2590 of 2876 id: cord-343832-xg3swuzs author: Pugliese, Daniela title: The management of Inflammatory Bowel Diseases in the era of COVID-19 pandemic: when “non-urgent” does not mean “deferrable” date: 2020-06-18 words: 1744 flesch: 33 summary: Transition from paediatric to adult health care setting is a crucial phase for IBD patients, requiring structured programs, joint paediatric-adult clinic and an approach tailored to the patients. 8 b) IBD patients with cancer: The management of IBD patients with cancer requires a strong multidisciplinary collaboration between gastroenterologists and oncologists. Risks and benefits of introducing/maintaining IBD medical therapies should be balanced for each patient, according to IBD clinical activity and cancer diagnosis. keywords: bowel; disease; ibd; patients; risk; treatment cache: cord-343832-xg3swuzs.txt plain text: cord-343832-xg3swuzs.txt item: #2591 of 2876 id: cord-343876-2inr4mcy author: Xie, Qin title: COVID-19 patients managed in psychiatric inpatient settings due to first-episode mental disorders in Wuhan, China: clinical characteristics, treatments, outcomes, and our experiences date: 2020-10-02 words: 4839 flesch: 35 summary: Because COVID-19 patients with new onset of mental disorders are different from psychiatric patients infected with SARS-CoV-2 and most COVID-19 patients in real-world clinical practice have no mental disorders before the infection, we did not include SARS-CoV-2-infected psychiatric patients as subjects. During the outbreak of COVID-19, the selection of an appropriate treatment setting for COVID-19 patients with mental disorders is a dilemma: in respiratory treatment settings these patients are more likely to not adhere with The main findings of this comparative study are 1) adjustment disorder and acute and transient psychotic disorders, with associated acute stress were the main clinical diagnoses in the COVID-19 group and some other disorders had their organic basis such as delirium due to infection and chloroquine-induced psychosis, while serious mental illnesses (SMIs) and alcohol use disorders were overrepresented in the control group, a common feature of inpatients of most Chinese psychiatric hospitals; 2) a wide range of psychiatric symptoms were found in COVID-19 patients with mental disorders on admission, including psychotic symptoms, aggressive behaviors, and anxiety symptoms; 3) the most common respiratory symptom of COVID-19 patients was cough, followed by fever, chills, and fatigue; and 4) mental disorders and COVID-19 of most patients were successfully treated after symptomatic and supportive treatments, including conventional psychotropic treatment and antiviral treatment, and, COVID-19 patients left the hospital earlier than psychiatric patients without COVID-19, on average by 16 days after admission. keywords: covid-19; covid-19 patients; disorders; group; hospital; patients; psychiatric; symptoms; treatment cache: cord-343876-2inr4mcy.txt plain text: cord-343876-2inr4mcy.txt item: #2592 of 2876 id: cord-343877-jzkaee16 author: Newdick, Chris title: Tragic choices in intensive care during the COVID-19 pandemic: on fairness, consistency and community date: 2020-08-07 words: 5266 flesch: 47 summary: Public authorities have wide discretion in making resource allocation decisions. We have sought to clarify for clinicians and front-line workers a framework which echoes in many respects the ethical frameworks developed for CCG resource allocation decisions more broadly, and which, subject to certain constraints and formalised processes, the law has accommodated. keywords: care; community; consistency; decision; individual; making; patients; rights cache: cord-343877-jzkaee16.txt plain text: cord-343877-jzkaee16.txt item: #2593 of 2876 id: cord-343897-f4imrltt author: Weimer, Louis H. title: Neuromuscular disorders in pregnancy date: 2020-08-04 words: 10286 flesch: 41 summary: Some options are strictly contraindicated, but many have limited available medical evidence for pregnancy risks. Pregnancy does not specifically cause generalized or polyneuropathy. keywords: cases; conditions; delivery; disease; dystrophy; et al; muscle; muscular; nerve; neuropathy; onset; patients; pregnancies; pregnancy; risk; study; syndrome; treatment; weakness; women cache: cord-343897-f4imrltt.txt plain text: cord-343897-f4imrltt.txt item: #2594 of 2876 id: cord-343917-67qjqxqh author: Dabrowska, Dominika title: Staying Ahead of the Curve: Modified Approach to Emergency Caesarean Section Under General Anaesthesia in COVID-19 Pandemic date: 2020-04-30 words: 3444 flesch: 41 summary: The aim of this review is to highlight the key recommendations related to obstetric anaesthesia from scientific bodies in the United Kingdom and United States and to summarize recently developed and implemented clinical pathways for care of obstetric patients – specifically those requiring urgent general anaesthesia for caesarean section within a large maternity unit in London. The key messages of this guidance are as follows: -COVID-19 diagnosis itself is not considered a contraindication for neuraxial anaesthesia -Early epidural analgesia may reduce the need for general anaesthesia for emergent caesarean delivery -All healthcare workers should implement droplet and contact precautions -Since the care of COVID-19 patients is time intensive, additional staffing may be needed and back-up strategies may need to be developed. keywords: anaesthesia; covid-19; delivery; general; intubation; patients; team; theatre cache: cord-343917-67qjqxqh.txt plain text: cord-343917-67qjqxqh.txt item: #2595 of 2876 id: cord-343970-anocx4y1 author: Bansal, Rashika title: Metabolic Syndrome and COVID 19: Endocrine-Immune-Vascular Interactions Shapes Clinical Course date: 2020-06-30 words: 6538 flesch: 33 summary: ACE2 is expressed in pancreatic islets, vascular endothelium, and adipose tissue, and the SARS-CoV-2 -ACE2 interaction in these tissues, along with other factors, govern the spectrum and the severity of clinical manifestations among COVID-19 patients with metabolic syndrome. This review describes the spectrum of clinical features, the likely pathophysiologic mechanisms and potential implications for the management of metabolic syndrome in COVID-19 patients. keywords: ace2; angiotensin; cell; coronavirus; cov-2; covid-19; diabetes; disease; infection; inflammatory; obesity; patients; risk; sars; type cache: cord-343970-anocx4y1.txt plain text: cord-343970-anocx4y1.txt item: #2596 of 2876 id: cord-343973-n5ogyxz7 author: Ip, Andrew title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 words: 4336 flesch: 40 summary: key: cord-343973-n5ogyxz7 authors: Ip, Andrew; Berry, Donald A.; Hansen, Eric; Goy, Andre H.; Pecora, Andrew L.; Sinclaire, Brittany A.; Bednarz, Urszula; Marafelias, Michael; Berry, Scott M.; Berry, Nicholas S.; Mathura, Shivam; Sawczuk, Ihor S.; Biran, Noa; Go, Ronaldo C.; Sperber, Steven; Piwoz, Julia A.; Balani, Bindu; Cicogna, Cristina; Sebti, Rani; Zuckerman, Jerry; Rose, Keith M.; Tank, Lisa; Jacobs, Laurie G.; Korcak, Jason; Timmapuri, Sarah L.; Underwood, Joseph P.; Sugalski, Gregory; Barsky, Carol; Varga, Daniel W.; Asif, Arif; Landolfi, Joseph C.; Goldberg, Stuart L. title: Hydroxychloroquine and tocilizumab therapy in COVID-19 patients—An observational study date: 2020-08-13 journal: PLoS One DOI: 10.1371/journal.pone.0237693 sha: doc_id: 343973 cord_uid: n5ogyxz7 Hydroxychloroquine has been touted as a potential COVID-19 treatment. This retrospective observational cohort study of 2512 hospitalized COVID-19 patients within a 13-hospital network did not find the empirical use of hydroxychloroquine with or without co-treatment with azithromycin to be associated with a reduction in mortality (adjusted HR, 0.99 for any hydroxychloroquine during hospitalization keywords: azithromycin; covid-19; drug; hospital; hydroxychloroquine; observational; patients; study; tocilizumab; treatment cache: cord-343973-n5ogyxz7.txt plain text: cord-343973-n5ogyxz7.txt item: #2597 of 2876 id: cord-344004-z7pn7u6u author: Shaha, Ashok R. title: Thyroid surgery during COVID‐19 pandemic: Principles and philosophies date: 2020-04-27 words: 2055 flesch: 52 summary: In a referral center or a tertiary care cancer center it is fairly common to receive consultations regarding thyroid problems or thyroid tumors. We need to explain every patient that thyroid tumors grow slowly and there is no need for active and emergent intervention. keywords: cancer; covid-19; health; patients; thyroid cache: cord-344004-z7pn7u6u.txt plain text: cord-344004-z7pn7u6u.txt item: #2598 of 2876 id: cord-344017-qldawc8m author: Edouard, S. title: Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France date: 2020-11-11 words: 4022 flesch: 40 summary: We used it to assess the serological status of hundreds of COVID-19 patients and controls; as such, an assay has been only reported on a very small group of patients [14, 15] . key: cord-344017-qldawc8m authors: Edouard, S.; Colson, P.; Melenotte, C.; Di Pinto, F.; Thomas, L.; La Scola, B.; Million, M.; Tissot-Dupont, H.; Gautret, P.; Stein, A.; Brouqui, P.; Parola, P.; Lagier, J.-C.; Raoult, D.; Drancourt, Michel title: Evaluating the serological status of COVID-19 patients using an indirect immunofluorescent assay, France date: 2020-11-11 journal: keywords: cov-2; covid-19; days; igg; outcome; patients; sars; sera cache: cord-344017-qldawc8m.txt plain text: cord-344017-qldawc8m.txt item: #2599 of 2876 id: cord-344104-592r71l1 author: Ardati, Amer K. title: Be Prepared date: 2020-03-17 words: 1120 flesch: 35 summary: 9,10 Regional variations in length of stay suggest a substantial opportunity to systematically reduce resource utilization in acute coronary syndrome patients nationwide. The Queen Mary Hospital STEMI report identifies 2 areas of concern for patients requiring acute cardiac care: (1) delays in presentation and (2) delays in treatment. keywords: care; healthcare; management; need; patients cache: cord-344104-592r71l1.txt plain text: cord-344104-592r71l1.txt item: #2600 of 2876 id: cord-344117-lr6roxej author: Vieira, Ana Luisa Silveira title: Role of point-of-care ultrasound during the COVID-19 pandemic: our recommendations in the management of dialytic patients date: 2020-06-03 words: 4408 flesch: 41 summary: Moreover, dialysis patients are more vulnerable to infection due to suppression of the immune system. Reports from health services around the world have indicated that patients with diabetes mellitus and hypertension, two of the main causes of ESRD worldwide, and also advanced age and cardiovascular complications, two frequent accompanying conditions in dialysis patients, are more susceptible to SARS-CoV-2 infection and more prone to develop severe COVID-19 pneumonia, eventually requiring intensive care treatment keywords: covid-19; disease; lines; lung; lus; patients; pneumonia; ultrasound cache: cord-344117-lr6roxej.txt plain text: cord-344117-lr6roxej.txt item: #2601 of 2876 id: cord-344120-7t5ce2hb author: Baroutjian, Amanda title: SARS-CoV-2 pharmacologic therapies and their safety/effectiveness according to level of evidence date: 2020-09-01 words: 5292 flesch: 49 summary: While we await higher quality evidence from randomized control trials and meta-analyses, these results provide some context on the efficacy of pharmacologic therapy in COVID-19 patients. In the absence of a vaccine available to the public, there is a great need for level 1 evidence from randomized controlled trials and meta-analyses to support the development of evidence-based guidelines to treat COVID-19 patients. keywords: clinical; covid-19; day; days; group; improvement; patients; time cache: cord-344120-7t5ce2hb.txt plain text: cord-344120-7t5ce2hb.txt item: #2602 of 2876 id: cord-344131-e7phs0jd author: Ford, Richard B. title: Section 4 Diagnostic and Therapeutic Procedures date: 2012-12-31 words: 40231 flesch: 50 summary: Doing so can enhance significantly the patient's tolerance for the displacement of skin during the period of administration and, in small patients, prevent hypothermia. Additional training and/or experience is recommended for performing tracheoscopy in small patients. keywords: administration; animal; aspiration; biopsy; biopsy needle; bladder; blood; bone; catheter; cats; cells; collection; contrast; culture; disease; dogs; end; examination; figure; fluid; hair; hours; marrow; material; nasal; needle; patient; place; pressure; procedure; sample; site; skin; slide; syringe; technique; tissue; tract; tube; urinary; urine; use cache: cord-344131-e7phs0jd.txt plain text: cord-344131-e7phs0jd.txt item: #2603 of 2876 id: cord-344135-pyibu6rj author: Zuo, Peiyuan title: Decreased prealbumin level is associated with increased risk of mortality in hospitalized elderly patients with COVID-19 date: 2020-07-03 words: 3735 flesch: 38 summary: AST = aspartate transaminase; Hs-cTnI, High-sensitive cardiac troponin I. Obesity and impaired metabolic health in patients with COVID-19 Special considerations for nutritional studies in elderly Low prealbumin concentration was associated with increased risk of worse outcomes (all-cause death, ICU admission and mechanical ventilation) in elderly COVID-19 patients The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up Transthyretin as a marker to predict outcome in critically ill patients Prealbumin improves death risk prediction of BNP-added Seattle Heart Failure Model: results from a pilot study in elderly chronic heart failure patients Serum prealbumin and its changes over time are associated with mortality in acute kidney injury Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan Clinical and CT features of early-stage patients with COVID-19: a retrospective analysis of imported cases in Shanghai, China Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease Prealbumin in nutrition evaluation Serum prealbumin: an independent marker of short-term energy intake in the presence of multiple-organ disease involvement The acute phase protein response in patients receiving subcutaneous IL-6 CRP/prealbumin, a novel inflammatory index for predicting recurrence after radical resection in gastric cancer patients: post hoc analysis of a randomized phase III trial Malnutrition in acute care patients: a narrative review Back to the Future: Lessons Learned From the 1918 SARS-CoV-2 and Zuo Peiyuan: Conceptualization, Methodology, Writing -Original Draft Each of the authors confirms that this manuscript has not been previously published and is not currently under consideration by any other journal. Univariate and multivariate logistic regression models were employed to evaluate the correlation between prealbumin and in-hospital outcomes (in-hospital mortality, ICU admission and mechanical ventilation) in elderly COVID-19 patients. keywords: admission; covid-19; disease; patients; prealbumin; risk; study cache: cord-344135-pyibu6rj.txt plain text: cord-344135-pyibu6rj.txt item: #2604 of 2876 id: cord-344185-jz6ui4w3 author: Aziz, Aleha title: Building an Obstetric Intensive Care Unit during the COVID-19 Pandemic at a Tertiary Hospital and Selected Maternal-Fetal and Delivery Considerations date: 2020-07-24 words: 4150 flesch: 29 summary: Responding rapidly to early warning signs of respiratory decompensation or worsening disease, following treatment protocols and best practices, working with interdisciplinary subspecialists, encouraging collaboration between physicians and nursing, and evaluating shortcomings in the system, were important elements in developing an effectively functioning OBICU that prioritized patient care and was optimized to provide the best possible outcomes for patients. As the subspecialist experts in critical care of obstetric patients, the MFM specialists and obstetric anesthesia physicians co-led the provision of critical care due to their understanding of physiological changes in pregnancy affecting health status, awareness regarding processes with potential for in-utero compromise, and alertness of complications endangering fetal well-being. keywords: care; covid-19; critical; delivery; labor; management; obicu; patients; physician; team; unit cache: cord-344185-jz6ui4w3.txt plain text: cord-344185-jz6ui4w3.txt item: #2605 of 2876 id: cord-344191-veug3dae author: Weiling, Lydia Li title: Digital health for patients with chronic pain during the COVID-19 pandemic date: 2020-08-10 words: 896 flesch: 32 summary: The Mental Health Consequences of COVID-19 and 203 Physical Distancing: The Need for Prevention and Early Intervention Chronic pain after COVID-19: implications for 206 rehabilitation Telecare collaborative 208 management of chronic pain in primary care: a randomized clinical trial COVID-19 transforms health care 211 through telemedicine: evidence from the field Managing patients with chronic pain during 214 the COVID-19 outbreak: considerations for the rapid introduction of remotely 215 supported (eHealth) pain management services Telemedicine for chronic pain management during 217 COVID-19 pandemic Video consultations for covid-19. key: cord-344191-veug3dae authors: Weiling, Lydia Li; Ming Kai, Alton Chew; Gunasekeran, Dinesh Visva title: Digital health for patients with chronic pain during the COVID-19 pandemic date: 2020-08-10 journal: keywords: chronic; pain; patients cache: cord-344191-veug3dae.txt plain text: cord-344191-veug3dae.txt item: #2606 of 2876 id: cord-344270-874i31h8 author: Radke, Robert M title: Adult congenital heart disease and the COVID-19 pandemic date: 2020-06-10 words: 4678 flesch: 35 summary: For example, patients with severely reduced systolic ventricular function would be considered high-risk individuals irrespective of underlying heart defect, whereas some patients with more complex lesions such as repaired tetralogy of Fallot or transposition of the great arteries after arterial switch operation with pristine haemodynamics are classified as lower risk patients. Based on the anatomy of the underlying cardiac lesion and additional physiological considerations such as symptoms, Review box 1 summary of specific considerations for severely affected AChD patients Key issues for critical care management of COVID-19 patients with congenital heart disease general considerations ► Admit to secondary or tertiary adults with congenital heart disease (ACHD) centre. keywords: achd; ards; care; covid-19; disease; heart; patients; right; risk; sars cache: cord-344270-874i31h8.txt plain text: cord-344270-874i31h8.txt item: #2607 of 2876 id: cord-344271-5aynmdsk author: de Souza Luna, Luciano Kleber title: Spectrum of Viruses and Atypical Bacteria in Intercontinental Air Travelers with Symptoms of Acute Respiratory Infection date: 2007-03-01 words: 2308 flesch: 51 summary: Respiratory infections during air travel Aircraft cabin air recirculation and symptoms of the common cold Prevalence of respiratory symptoms among female flight attendants and teachers Transmission of infectious diseases during commercial air travel Community-acquired pneumonia Identification of a novel coronavirus in patients with severe acute respiratory syndrome Internally controlled real-time PCR monitoring of adenovirus DNA load in serum or plasma of transplant recipients Amplicon sequencing and improved detection of human rhinovirus in respiratory samples Cloning of a human parvovirus by molecular screening of respiratory tract samples Single-run, parallel detection of DNA from three pneumonia-producing bacteria by real-time polymerase chain reaction Evidence of human coronavirus HKU1 and human bocavirus in Australian children Detection of human bocavirus in Japanese children with lower respiratory tract infections Enhanced identification of viral and atypical bacterial pathogens in lower respiratory tract samples with nucleic acid amplification tests Surveillance of respiratory virus infections in adult hospital admissions using rapid methods Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season Respiratory samples ( ) from n p 214 172 patients were available. keywords: contact; detection; flight; patients; samples cache: cord-344271-5aynmdsk.txt plain text: cord-344271-5aynmdsk.txt item: #2608 of 2876 id: cord-344302-p0v6sl9x author: Gubitosa, James C title: COVID-19-Associated Acute Limb Ischemia in a Patient on Therapeutic Anticoagulation date: 2020-09-25 words: 3104 flesch: 36 summary: Role of endothelial inflammation Arterial thromboembolic complications in COVID-19 in low-risk patients despite prophylaxis Endothelial cell infection and endotheliitis in COVID-19 Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases Prominent changes in blood coagulation of patients with SARS-CoV-2 infection Hypercoagulability of COVID-19 patients in intensive care unit. A case series by Gonzalez et al. described three cases of peripheral arterial thrombosis in COVID-19 patients [7] . keywords: anticoagulation; covid-19; patient; reference; thrombosis cache: cord-344302-p0v6sl9x.txt plain text: cord-344302-p0v6sl9x.txt item: #2609 of 2876 id: cord-344389-aj9q73f0 author: Brosnahan, Shari B. title: COVID-19 Pneumonia Hospitalizations Followed by Re-presentation for Presumed Thrombotic Event date: 2020-06-23 words: 1670 flesch: 35 summary: These observations have raised our concern regarding a continued hypercoagulable state in COVID-19 patients despite clinical stability that exists post-hospitalization; patients with certain risk factors may benefit from extended VTE prophylaxis. 15 While classic disseminated intravascular coagulation (DIC) has also been identified in certain COVID-19 patients, the incidence of this is seemingly rare. keywords: covid-19; discharge; patients; prophylaxis; thrombosis cache: cord-344389-aj9q73f0.txt plain text: cord-344389-aj9q73f0.txt item: #2610 of 2876 id: cord-344431-2wq7msqz author: Holzinger, Felix title: Self-referred walk-in patients in the emergency department – who and why? Consultation determinants in a multicenter study of respiratory patients in Berlin, Germany date: 2020-09-10 words: 7367 flesch: 39 summary: Utilization motives of non-urgent ED patients have been evaluated in various settings Much has been written about non-urgent ED patients and inappropriate utilization. keywords: access; care; consultation; department; emergency; health; motives; network; non; patients; self; srw; study; utilization cache: cord-344431-2wq7msqz.txt plain text: cord-344431-2wq7msqz.txt item: #2611 of 2876 id: cord-344486-iu5flbcl author: Chiotos, Kathleen title: Multicenter interim guidance on use of antivirals for children with COVID-19/SARS-CoV-2 date: 2020-09-12 words: 8619 flesch: 24 summary: Antiviral Activity and Safety of Darunavir/Cobicistat for the Treatment of COVID-19 Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis Stopping lopinavir/ritonavir in COVID-19 patients: duration of the drug interacting effect Clinical Characteristics and Disease Progression in Early-Stage COVID-19 Patients in South Korea Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study Guidance statement: Remdesivir is suggested for children with severe COVID-19. keywords: children; coronavirus; covid-19; data; days; disease; hydroxychloroquine; patients; pediatric; remdesivir; risk; sars; study; treatment; trial; use cache: cord-344486-iu5flbcl.txt plain text: cord-344486-iu5flbcl.txt item: #2612 of 2876 id: cord-344508-a67vsux2 author: Campanile, Fabio Cesare title: Acute cholecystitis during COVID-19 pandemic: a multisocietary position statement date: 2020-06-08 words: 2397 flesch: 36 summary: Langenbeck's Arch Surg Laparoscopic approach to acute abdomen from the Consensus Development Conference of the Società Italiana di Chirurgia Endoscopica e nuove tecnologie (SICE) WSES and SICG guidelines on acute calcolous cholecystitis in elderly population Surgical smoke and infection control Detecting hepatitis B virus in surgical smoke emitted during laparoscopic surgery SARS-C oV-2 is present in peritoneal fluid in COVID-19 patients. E-published ahead-of-print A low cost, safe and effective method for smoke evacuation in laparoscopic surgery for suspected coronavirus patients Systematic review of cholecystostomy as a treatment option in acute cholecystitis Cholecystectomy in elderly: challenge and critical analysis of available evidence Outcome comparison between percutaneous cholecystostomy and cholecystectomy: a 10-year population-based analysis Emergent cholecystectomy is superior to percutaneous cholecystostomy tube placement in critically ill patients with emergent calculous cholecystitis Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial Early percutaneous cholecystostomy in severe acute cholecystitis reduces the complication rate and duration of hospital stay Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations All the authors contributed equally to this article. keywords: acute; cholecystectomy; cholecystitis; covid-19; patients; surgery cache: cord-344508-a67vsux2.txt plain text: cord-344508-a67vsux2.txt item: #2613 of 2876 id: cord-344668-9m1vnpmo author: Nitkunan, Arani title: COVID-19: switching to remote neurology outpatient consultations date: 2020-05-04 words: 1732 flesch: 55 summary: ► Remote consultations cannot be a substitute for all face-to-face consultations; outside the COVID-19 context, we should consider individualised standards for such consultations. 1 2 There is a lack of research data on using remote consultations for new neurology outpatients and only low-level evidence for their use in general practice. keywords: consultations; face; patient; telephone cache: cord-344668-9m1vnpmo.txt plain text: cord-344668-9m1vnpmo.txt item: #2614 of 2876 id: cord-344693-znw3dru4 author: Lima, Brian title: COVID‐19 in recent heart transplant recipients: Clinicopathologic features and early outcomes date: 2020-07-08 words: 1845 flesch: 33 summary: To the best of our knowledge, the outcomes of HTx patients infected with COVID-19 within the early post-transplant period have not been previously reported, nor have the findings of electron microscopy to evaluate direct myocardial involvement of SARS-CoV-2 in immunosuppressed patients. Increased risk of severe illness is suggested by a recent study which reported a mortality rate of 25% among HTx patients with COVID-19 in a single transplant center. keywords: cases; covid-19; disease; heart; htx; patients; transplant cache: cord-344693-znw3dru4.txt plain text: cord-344693-znw3dru4.txt item: #2615 of 2876 id: cord-344709-5hy1e4t1 author: Patel, Brijesh V. title: Pulmonary Angiopathy in Severe COVID-19: Physiologic, Imaging, and Hematologic Observations date: 2020-09-01 words: 4519 flesch: 32 summary: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus: a first step in understanding SARS pathogenesis SARS-coronavirus open reading Frame-3a drives multimodal necrotic cell death Thrombosis as an intravascular effector of innate immunity Eicosanoid storm in infection and inflammation Early intravascular events are associated with development of acute respiratory distress syndrome: a substudy of the LIPS-A clinical trial Natural history of venous thromboembolism Pandemic H1N1 influenza infection and vascular thrombosis Acute thrombotic vascular events complicating influenza-associated pneumonia Acute pulmonary embolism and COVID-19 pneumonia: a random association? COVID-19 complicated by acute pulmonary embolism Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2,540 severely injured patients Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis Thromboelastography in patients with severe sepsis: a prospective cohort study The rate of deep vein thrombosis doubles in trauma patients with hypercoagulable thromboelastography Author disclosures are available with the text of this article at www.atsjournals.org. Dilated peripheral vessels were present in 21/33 (63.6%) patients with at least two assessable lobes (including 10/21 [47.6%] with no evidence of acute pulmonary emboli). keywords: acute; covid-19; dect; lung; patients; perfusion; pneumonia; vascular; vessels cache: cord-344709-5hy1e4t1.txt plain text: cord-344709-5hy1e4t1.txt item: #2616 of 2876 id: cord-344729-sjjedgws author: Bhaskar, Sonu title: Acute Neurological Care in the COVID-19 Era: The Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium Pathway date: 2020-05-29 words: 3717 flesch: 36 summary: • To ensure the quality of stroke care for COVID-19 stroke patients, such patients could be admitted to other wards for COVID-19 positive patients. However, these latter guidelines do not address the issue of separating COVID-19 patients from others in terms of scanning equipment, radiology suites, and decontamination protocols. keywords: acute; covid-19; healthcare; infection; management; pandemic; patients; stroke; workers cache: cord-344729-sjjedgws.txt plain text: cord-344729-sjjedgws.txt item: #2617 of 2876 id: cord-344765-agt60ksx author: Bhogal, R.H. title: Approach to upper GastroIntestinal cancer surgery during the COVID-19 pandemic – Experience from a UK cancer centre date: 2020-05-30 words: 664 flesch: 22 summary: Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China COVID-19 infection in patients following hepato-pancreatico-biliary intervention: An early experience This framework has allowed us to triage Upper GI cancer patients in a resource-limited environment and safely deliver the maximum number of potentially curative operations during the COVID-19 pandemic. keywords: cancer; patients; surgery cache: cord-344765-agt60ksx.txt plain text: cord-344765-agt60ksx.txt item: #2618 of 2876 id: cord-344853-s2p2csrx author: Hendren, Nicholas S. title: Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome date: 2020-04-16 words: 6698 flesch: 27 summary: Med J Chinese People's Liberation Army Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer Pathological study of impact of SARS coronavirus on heart and its conduction system in SARS patients. In this document, we focus on a prominent myocarditis-like syndrome involving acute myocardial injury often associated with reduced left ventricular ejection fraction in the absence of obstructive coronary artery disease. keywords: acovcs; acute; cardiac; coronavirus; cov-2; covid-19; disease; heart; injury; myocarditis; patients; sars; syndrome cache: cord-344853-s2p2csrx.txt plain text: cord-344853-s2p2csrx.txt item: #2619 of 2876 id: cord-344939-rgxqobfw author: Ng, C. W. Q. title: Maintaining breast cancer care in the face of COVID‐19 date: 2020-08-24 words: 1482 flesch: 38 summary: The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials International guidelines on radiation therapy for breast cancer during the COVID-19 pandemic COVID-19: Global radiation oncology's targeted response for pandemic preparedness The authors acknowledge the breast care team at National University Hospital for collating the operational numbers used to complete Table 1 , and for their continued efforts to provide the best care for patients. Systems are strained though adequate, with significant rerouting of resources to COVID-19 care. keywords: breast; cancer; care; covid-19; patients cache: cord-344939-rgxqobfw.txt plain text: cord-344939-rgxqobfw.txt item: #2620 of 2876 id: cord-344967-t88pedeb author: Tang, Hon Lok title: Severe acute respiratory syndrome in haemodialysis patients: a report of two cases date: 2003-10-17 words: 1671 flesch: 59 summary: We describe here two end-stage renal failure patients, both receiving chronic haemodialysis, who acquired the disease after contact with SARS patients and had different outcomes. He had a history of contact with SARS patients. keywords: day; days; patient; sars cache: cord-344967-t88pedeb.txt plain text: cord-344967-t88pedeb.txt item: #2621 of 2876 id: cord-345028-56hg62be author: Flinspach, Armin Niklas title: Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients—A Case Series and Systematic Review date: 2020-10-21 words: 4122 flesch: 29 summary: To the best of our knowledge, no studies have investigated the effect of isoflurane sedation in patients suffering from C-ARDS so far, and it remains understudied whether the observed pathophysiologic pulmonary abnormalities, such as exudative and proliferative phases of a diffuse alveolar injury, might have an impact on the feasibility of volatile sedation (25) (26) (27) . In this first report of applying volatile sedation in patients with C-ARDS, we demonstrated the feasibility of isoflurane sedation in five cases. keywords: anesthetics; ards; care; coronavirus; covid-19; isoflurane; patients; sedation; ventilation cache: cord-345028-56hg62be.txt plain text: cord-345028-56hg62be.txt item: #2622 of 2876 id: cord-345044-2fez1gu0 author: Proenca‐Modena, José Luiz title: Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children date: 2019-03-18 words: 3198 flesch: 27 summary: Although HAdV infections are generally asymptomatic in immunocompetent individuals, acute HAdV diseases have a significant impact on children (especially under 4 years of age), elderly, immunosuppressed individuals, and military recruits. The near 50% detection rate of the HAdV genome reported herein confirms previous findings and agrees with adenoids being preferred sites of HAdV infection when compared with PTs. keywords: adenoids; adenovirus; copies; hadv; human; patients cache: cord-345044-2fez1gu0.txt plain text: cord-345044-2fez1gu0.txt item: #2623 of 2876 id: cord-345092-1ztfcpsb author: Iwasaki, Masae title: Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications date: 2020-10-08 words: 11452 flesch: 39 summary: Retrospective study Structure analysis of the receptor binding of 2019-nCoV. Biochemical and Biophysical Research Communications Kidney disease is associated with in-hospital death of patients with COVID-19 A simple approximate mathematical model to predict the number of severe acute respiratory syndrome cases and deaths Cytokine storm and sepsis disease pathogenesis Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis Angiotensin II activates programmed myocyte cell death in vitro Activation of the AT(2) receptor of angiotensin II induces neurite outgrowth and cell migration in microexplant cultures of the cerebellum Nitric oxide, a new second messenger involved in the action of angiotensin II on neuronal differentiation of NG108-15 cells The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19) Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: Implications for pathogenesis and virus transmission pathways Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system The spike protein of SARS-CoV-a target for vaccine and therapeutic development The Apelin-APJ axis is an endogenous counterinjury mechanism in experimental acute lung injury Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection Acute respiratory distress syndrome: The Berlin definition Renin-angiotensin system revisited Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19 Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding Kawasaki disease complicated with macrophage activation syndrome: A systematic review Hydroxychloroquine and azithromycin as a treatment of COVID-19: Results of an open-label nonrandomized clinical trial The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response Remdesivir for 5 or 10 days in patients with severe covid-19 Compassionate use of remdesivir for patients with severe covid-19 Clinical characteristics of coronavirus disease 2019 in China Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry The emerging role of ACE2 in physiology and disease Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. This review summarizes the current evidence and understanding of the underlying mechanisms of SARS-CoV-2, ACE2 and inflammation co-mediated multi-organ injury or failure in COVID-19 patients. keywords: ace2; acute; ang2; angiotensin; cells; coronavirus; cov-2; covid-19; covid-19 patients; cytokine; disease; host; il-6; infection; injury; lung; patients; protein; receptor; sars; study; syndrome cache: cord-345092-1ztfcpsb.txt plain text: cord-345092-1ztfcpsb.txt item: #2624 of 2876 id: cord-345296-4z7yfj5s author: Ho, Mei-Shang title: Neutralizing Antibody Response and SARS Severity date: 2005-11-17 words: 4603 flesch: 32 summary: Autopsies of SARS patients have found the virus to be widespread throughout a variety of tissues and organs (8) . To validate the consistency of the interhospital practices in patient care in relation to the severity of patients, we collected and analyzed anonymous and computerized clinical data, focusing on oxygen supplementation and respiratory therapy, on a sample of SARS patients from 3 hospitals that represented 3 healthcare accreditation levels in Taiwan: a major medical center (National Taiwan University Hospital), a regional teaching hospital (Taipei Mackay Memorial Hospital), and a district hospital (Taipei Hospital). keywords: acute; antibody; illness; infection; patients; sars; syndrome; weeks cache: cord-345296-4z7yfj5s.txt plain text: cord-345296-4z7yfj5s.txt item: #2625 of 2876 id: cord-345371-pjbviagq author: Lisi, Lucia title: Approaching Coronavirus Disease 2019: mechanisms of action of repurposed drugs with potential activity against SARS-CoV-2 date: 2020-07-23 words: 10674 flesch: 18 summary: Among them, the international Solidarity trial launched by the WHO on March 2020 with the aim to find an effective treatment for COVID-19 patients by comparing four different treatments (i.e., lopinavir/ritonavir, lopinavir/ritonavir plus interferon-β, chloroquine/hydroxychloroquine or remdesivir) against standard of care (see also sections 2 and 3). Besides exerting potential direct antiviral effects, baricitinib might prevent the dysregulated production of pro-inflammatory cytokines typically observed in COVID-19 patients via the inactivation of interleukin-6 (IL6)-JAK-signal transducer and activator of transcription (STAT) pathway (this activity will be more deeply discussed in section 3, especially regarding the JAK inhibitor ruxolitinib). keywords: acute; cells; coronavirus; cov-2; covid-19; covid-19 patients; disease; hydroxychloroquine; infection; interferon; patients; pneumonia; protein; remdesivir; ritonavir; rna; sars; study; syndrome; tocilizumab; treatment; use cache: cord-345371-pjbviagq.txt plain text: cord-345371-pjbviagq.txt item: #2626 of 2876 id: cord-345381-9cckppk2 author: Klimek, Ludger title: Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Ärzteverband Deutscher Allergologen (AeDA)(A), Deutsche Gesellschaft für Allergologie und Klinische Immunologie (DGAKI)(B), Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)(C), Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI)(D), Luxemburgische Gesellschaft für Allergologie und Immunologie (LGAI)(E), Österreichische Gesellschaft für Pneumologie (ÖGP)(F) in co-operation with the German, Austrian, and Swiss ARIA groups(G), and the European Academy of Allergy and Clinical Immunology (EAACI)(H) date: 2020-09-07 words: 6158 flesch: 34 summary: Epub ahead of print SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan High IL-6/IFN-γ ratio could be associated with severe disease in COVID-19 patients The society for immunotherapy of cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response Why judiciously timed anti-IL 6 therapy may be of benefit in severe COVID-19 infection. COVID-19 patients with a history of respiratory disease develop ARDS more frequently (58 vs. 42%; 14 vs. 11 patients; of these, 4 vs. 2 patients with asthma; n = 50) ARDS = acute respiratory distress syndrome. keywords: asthma; atopic; biologicals; cells; coronavirus; course; cov-2; covid-19; disease; infection; pandemic; patients; risk; sars; therapy; treatment; type cache: cord-345381-9cckppk2.txt plain text: cord-345381-9cckppk2.txt item: #2627 of 2876 id: cord-345445-9t1vebey author: Radmanesh, Alireza title: COVID-19–associated Diffuse Leukoencephalopathy and Microhemorrhages date: 2020-05-21 words: 2233 flesch: 29 summary: Although initial reports of brain imaging findings in patients with COVID-19 showed ischemic and hemorrhagic complications (2, 5) , there are now increasing reports of other findings such as patchy demyelinating lesions (6) and acute hemorrhagic necrotizing encephalopathy involving the thalami and medial temporal lobes (3). Patients with abnormal white matter T2 hyperintensities (more than expected for agerelated microangiopathy on the basis of visual qualitative assessment) and/or microhemorrhages (4 mm in size) were included in the series. keywords: brain; matter; microhemorrhages; patients; relationships; white cache: cord-345445-9t1vebey.txt plain text: cord-345445-9t1vebey.txt item: #2628 of 2876 id: cord-345517-ji4cet51 author: Duarte de Araújo, António Manuel Silva title: Copd: will there be room for nebulisers after the current covid-19 pandemic? date: 2020-09-16 words: 1343 flesch: 31 summary: In the future, a dual inhibitor of phosphodiesterase 3 and phosphodiesterase 4 enzymes, developed for use as nebulisation, could be used as maintenance therapy for COPD patients, because of the bronchodilator and anti-inflammatory related effects.8 In a recent systematic review and meta-analysis, high doses of nebulised budesonide during hospitalisation, seemed to be non-inferior to systemic corticosteroids, in the treatment of COPD acute exacerbations.9 Nebulised corticosteroids can also be preferable versus oral prednisolone in patients with diabetes mellitus or with heart failure, because of the mineralocorticoid effects and fluid retention related to systemic corticosteroids. A subgroup of COPD patients is known to present chronic bronchial infection, and the use of antibiotics can be associated with reduction of bacterial load.10 Low doses of nebulised antibiotics can provide higher tissue concentration with fewer bacterial-resistance related issues. keywords: copd; inhalers; nebulisers; patients cache: cord-345517-ji4cet51.txt plain text: cord-345517-ji4cet51.txt item: #2629 of 2876 id: cord-345546-v7t26oos author: Wilenius, Lukas title: Attention-Deficit/Hyperactivity Disorder Patients May Have Undiagnosed Narcolepsy date: 2020-06-04 words: 3231 flesch: 51 summary: Our aim was to clarify the prevalence of narcolepsy symptoms among adult ADHD patients as compared to controls of the same age and gender. As such, narcolepsy could be masked in ADHD patients. keywords: adhd; iron; levels; narcolepsy; patients; serum; symptoms cache: cord-345546-v7t26oos.txt plain text: cord-345546-v7t26oos.txt item: #2630 of 2876 id: cord-345611-xv62h83a author: Cavalcanti, A. B. title: Hydroxychloroquine alone or in combination with azithromycin to prevent major clinical events in hospitalised patients with coronavirus infection (COVID-19): rationale and design of a randomised, controlled clinical trial date: 2020-05-26 words: 4292 flesch: 42 summary: key: cord-345611-xv62h83a authors: Cavalcanti, A. B.; Zampieri, F. G.; Azevedo, L. C.; Rosa, R. G.; Avezum, A.; Veiga, V. C.; Lopes, R. D.; Kawano-Dourado, L.; Damiani, L. P.; Pereira, A. J.; Serpa Neto, A.; Furtado, R.; Tomazini, B.; Bozza, F. A.; Maia, I. S.; Falavigna, M.; Lisboa, T. C.; Fonseca, H.; Machado, F. R.; Berwanger, O.; Investigators, COALITION COVID-19 Brazil I title: Hydroxychloroquine alone or in combination with azithromycin to prevent major clinical events in hospitalised patients with coronavirus infection (COVID-19): rationale and design of a randomised, controlled clinical trial date: 2020-05-26 journal: nan DOI: 10.1101/2020.05.19.20106997 sha: doc_id: 345611 cord_uid: xv62h83a Introduction: Hydroxychloroquine and its combination with azithromycin have been suggested to improve viral clearance in patients with COVID-19, but its effect on clinical outcomes remains uncertain. https://doi.org/10.1101/2020.05.19.20106997 doi: medRxiv preprint Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomised clinical trial Online ahead of print Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19 Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in P atients With COVID-19 in New York State Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomised Clinical Trial Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Statement: Defining standard protocol items for clinical trials A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19 Repeated assessments of results in clinical trials of cancer treatment Design and analysis of randomized clinical trials requiring prolonged observation of each patient. keywords: covid-19; days; hydroxychloroquine; license; medrxiv; patients; preprint; protocol; study cache: cord-345611-xv62h83a.txt plain text: cord-345611-xv62h83a.txt item: #2631 of 2876 id: cord-345628-a4c46m2w author: Unudurthi, Sathya D. title: Cardiac inflammation in COVID-19: Lessons from heart failure date: 2020-09-21 words: 7735 flesch: 25 summary: Different types of immune cells play an important role in promoting and regulating cardiac inflammation, and timing as well as identity of inflammatory cell infiltration in heart may vary, depending on the stimulus Inflammation Mechanisms Underlying Ischemic Cardiac Injury: Cardiac ischemia caused by formation of an occlusive thrombus within the coronary artery leads to myocyte necrosis, triggering intense sterile inflammation and immune cell infiltration in hearts. key: cord-345628-a4c46m2w authors: Unudurthi, Sathya D.; Luthra, Priya; Bose, Rajendran J.C.; McCarthy, Jason; Kontaridis, Maria Irene title: Cardiac inflammation in COVID-19: Lessons from heart failure date: 2020-09-21 journal: Life Sci DOI: 10.1016/j.lfs.2020.118482 sha: doc_id: 345628 cord_uid: a4c46m2w Cardiovascular disease (CVD) is the most common co-morbidity associated with COVID-19 and the fatality rate in COVID-19 patients with CVD is highest compared to other comorbidities, such as hypertension and diabetes. keywords: cells; coronavirus; cov-2; covid-19; disease; et al; heart; infection; infiltration; inflammation; injury; ischemic; mechanisms; patients; remodeling; sars cache: cord-345628-a4c46m2w.txt plain text: cord-345628-a4c46m2w.txt item: #2632 of 2876 id: cord-345632-iha2c5zo author: Hamdy, Sherif M title: Management Strategies of Patients with Neuromyelitis Optica Spectrum Disorder During the COVID-19 Pandemic Era date: 2020-08-17 words: 3994 flesch: 25 summary: Here, however, we examined the evidence of NMOSD disease-modifying therapies (DMTs) use during the present period and highlighted different scenarios including treatment of relapses as well as initiation and maintenance of DMTs in order to optimize care of NMOSD patients in the COVID-19 era. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified as the cause of coronavirus disease 2019 , is the third known virus of the coronaviridae family to cause outbreaks of severe acute respiratory syndrome. 13 Tailored recommendations for neurologists managing NMOSD patients are currently needed, especially in the case of patients acquiring COVID-19. keywords: covid-19; disease; infection; management; neuromyelitis; nmosd; optica; pandemic; patients; risk; spectrum; treatment cache: cord-345632-iha2c5zo.txt plain text: cord-345632-iha2c5zo.txt item: #2633 of 2876 id: cord-345655-fb4vv4my author: Islam, M. Z. title: Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in Bangladesh date: 2020-10-29 words: 3425 flesch: 52 summary: key: cord-345655-fb4vv4my authors: Islam, M. Z.; Riaz, B. K.; Islam, A. N. M. S.; Khanam, F.; Akhter, J.; Choudhury, R.; Farhana, N.; Jahan, N. A.; Uddin, M. J.; Efa, S. S. title: Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28th day of the disease course: a retrospective cohort study in Bangladesh date: 2020-10-29 journal: Epidemiology and infection DOI: 10.1017/s0950268820002630 sha: doc_id: 345655 cord_uid: fb4vv4my Diverse risk factors intercede the outcomes of coronavirus disease 2019 (COVID-19). Therefore, it is irrefutably obligatory to determine the risk factors to avert the aggressive consequences of COVID-19 patients. keywords: covid-19; disease; mortality; patients; risk; study cache: cord-345655-fb4vv4my.txt plain text: cord-345655-fb4vv4my.txt item: #2634 of 2876 id: cord-345680-10phij1x author: Terpos, Evangelos title: Hematological findings and complications of COVID‐19 date: 2020-05-23 words: 2695 flesch: 32 summary: A polymorphisms in the promoter region of TNF-alpha gene associate with enhanced apoptosis of lymphocytes in HIV-1 subtype C infected individuals from North India IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha Increased TNF-alpha-induced apoptosis in lymphocytes from aged humans: changes in TNF-alpha receptor expression and activation of caspases Simulation of the clinical and pathological manifestations of Coronavirus Disease 2019 (COVID-19) in golden Syrian hamster model: implications for disease pathogenesis and transmissibility The official French guidelines to protect patients with cancer against SARS-CoV-2 infection Inhibitory effect of tumor cellderived lactic acid on human T cells Clinical characteristics of coronavirus disease 2019 in China Clinical features of patients infected with 2019 novel coronavirus in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore Hematologic parameters in patients with COVID-19 infection Haematological parameters in severe acute respiratory syndrome A major outbreak of severe acute respiratory syndrome in Hong Kong Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients Dysregulation of immune response in patients with COVID-19 in Wuhan, China Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State Covid-19 in critically ill patients in the seattle region -case series Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. 36 2.2 | The emerging role of biomarkers procalcitonin, ferritin and C-reactive protein in the prognosis Coagulation disorders are relatively frequently encountered among COVID-19 patients, especially among those with severe disease. keywords: blood; china; coronavirus; covid-19; disease; lymphocyte; patients cache: cord-345680-10phij1x.txt plain text: cord-345680-10phij1x.txt item: #2635 of 2876 id: cord-345727-bcxkycjh author: Karimata, Yosuke title: Clinical Features of Human Metapneumovirus Pneumonia in Non-Immunocompromised Patients: An Investigation of Three Long-Term Care Facility Outbreaks date: 2018-09-15 words: 3381 flesch: 40 summary: Patients with hMPV infection were identified during 3 independent LTCF outbreaks in Okinawa, a subtropical region of Japan. During the outbreaks, 105 patients with hMPV infections (30 confirmed cases and 75 probable cases) were identified. keywords: cases; hmpv; human; infection; metapneumovirus; outbreak; patients; pneumonia cache: cord-345727-bcxkycjh.txt plain text: cord-345727-bcxkycjh.txt item: #2636 of 2876 id: cord-345762-khvcoqti author: Scott, Ian A. title: COVID‐19 pandemic and the tension between the need to act and the need to know date: 2020-08-06 words: 3441 flesch: 30 summary: This author also spoke to the media extolling the virtues of AC in all COVID-19 patients admitted to intensive care and announced that the Mount Sinai hospital system had changed its protocols to begin giving such patients therapeutic doses of AC. Hopefully, the same problems will not occur with remdesivir, whichdespite limited and conflicting evidence of clinical improvement from only two placebo-controlled RCT 19, 20 and one non-controlled cohort study 5has now become a 'standard of care' in the United States for COVID-19 patients with severe pneumonia. keywords: adaptive; covid-19; drug; patients; therapies; treatment; trial cache: cord-345762-khvcoqti.txt plain text: cord-345762-khvcoqti.txt item: #2637 of 2876 id: cord-345779-frspku51 author: Pinto, Antonio title: Interventional radiology in gynaecology and obstetric practice: safety issues date: 2020-09-30 words: 4390 flesch: 26 summary: ©e B: Role of interventional radiology in the management of infection Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous imageguided interventions A Primer to understanding the elements of medical malpractice Quality improvement guidelines for recording patient radiation dose in the medical record Ethics policies and procedures in imaging and interventional radiology Informed consent for radiation in interventional radiology procedures Practical recommendations for the application of DE 59/2013 Physicians' liability in interventional radiology and endovascular therapy Informed consent for interventional radiology procedures: a survey detailing current European practice Use of contrast media in diagnostic imaging: medico-legal considerations Interventional radiology in the pregnant patient for obstetric and nonobstetric indications: organizational, anesthetic, and procedural issues Patient-centered radiology Improving the informed consent conversation: a standardized checklist that Is patient centered, quality driven, and legally sound FIGURES Figure 1 Interventional radiology: a half century of innovation Evaluation of tablet ultrasound for routine abdominal interventional procedures Role of the interventional radiologist in treating obstetric-gynecologic pathology Transarterial embolization of peripheral high-flow arteriovenous malformation with ethylene vinyl alcohol copolymer (Onyx®): single-center 10-year experience Traumatic and spontaneous hemothorax due to intercostal arteries hemorrhage: what the interventional radiologist needs to know Role of interventional radiology in managing gastrointestinal bleedings Obstetric and gynecologic emergencies: a review of indications and interventional techniques Beyond hemostasis: spectrum of gynecologic and obstetric indications for transcatheter embolization Arterial bleeding in pelvic trauma: priorities in angiographic embolization Acute active bleedings after pelvic trauma: imaging and endovascular treatment Obstetric (nonfetal) complications Predelivery uterine arteries embolization in patients with placental implant anomalies: a cost-effective procedure Interventional radiology in pregnancy complications: indications, technique, and methods for minimizing radiation exposure Role of interventional procedures in obstetrics and gynecology Role of interventional radiology in obstetric and gynecological diseases Uterine fibroid embolization efficacy and safety: 15 years experience in an elevated turnout rate center The role of interventional radiology in obstetric and gynaecology practice Uterine artery embolization with gelfoam for acquired symptomatic uterine arterio venous shunting Severe metrorrhagia in patients with advanced gynecologic cancer: endovascular treatment benefits in acute and chronic setting Postpartum hemorrhage: what every radiologist needs to know Role of interventional radiology in treating obstetric haemorrhages Predelivery uterine arteries embolization in patients affected by placental implant anomalies Radiology and patient safety Quality improvement guidelines for preventing wrong site, wrong procedure, and wrong person errors: application of the joint commission universal protocol for preventing wrong site, wrong procedure, wrong person surgery to the practice of interventional radiology Reducing error and improving efficiency during vascular interventional radiology: im plementation of a preprocedural team keywords: care; consent; embolization; errors; patient; procedure; radiology; safety; suite cache: cord-345779-frspku51.txt plain text: cord-345779-frspku51.txt item: #2638 of 2876 id: cord-345860-d02x3151 author: Thome, Johannes title: The impact of the COVID-19 outbreak on the medico-legal and human rights of psychiatric patients date: 2020-05-29 words: 1742 flesch: 24 summary: Considering these value-based principles, practical advices for mental health workers on how to protect and defend the rights of patients with severe mental illness in the circumstances of a pandemic may include: (a) close links being built and maintained with nonmedical professionals (such as those within the legal sector) involved in psychiatric patient care; (b) regular contact with external agents being maintained to ensure that no unilateral decisions are taken without prior consultation with mental health experts, representatives of patients, and their relatives; (c) expert information about the medical (and not just psychiatric) background of patients being communicated to these external agents with a special emphasis on the presence of infectious disease and on possible preventive measures; (d) the use of electronic means of communication being used as a possible route to guaranteeing patients' access to their fundamental rights while simultaneously protecting the health of their legal representatives; and (e) awareness being created for the special needs of vulnerable groups (such as psychiatric patients) by mental health professionals in collaboration with decision-makers in social services and political and legal institutions. We believe that this represents a paradigm shift in psychiatric care and that the consideration of the fundamental rights of psychiatric patients as “less important” than infection control measures compel mental health professionals to “advocate for … patients and their caregivers” in this time of crisis [1]. keywords: covid-19; health; patients; rights cache: cord-345860-d02x3151.txt plain text: cord-345860-d02x3151.txt item: #2639 of 2876 id: cord-346015-bzeqs5oh author: Wang, Yeming title: Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial date: 2020-04-29 words: 5241 flesch: 39 summary: The median age of study patients was 65 years (IQR 56-71); sex distribution was 89 (56%) men versus 69 (44%) women in the remdesivir group and 51 (65%) versus 27 (35%) in the placebo group (table 1). In patients with use of remdesivir within 10 days after symptom onset, 28-day mortality was not significantly different between the groups, although numerically higher in the placebo group; by contrast, in the group of patients with late use, remdesivir patients had numerically higher 28-day mortality, although there was no significant difference. keywords: clinical; covid-19; days; group; patients; placebo; remdesivir; sars; study; time; treatment; trial cache: cord-346015-bzeqs5oh.txt plain text: cord-346015-bzeqs5oh.txt item: #2640 of 2876 id: cord-346061-pbghgitg author: Passanisi, Stefano title: Quarantine Due to the COVID-19 Pandemic From the Perspective of Pediatric Patients With Type 1 Diabetes: A Web-Based Survey date: 2020-07-31 words: 2350 flesch: 39 summary: Psychological and behavioral disorders in T1D pediatric patients have been demonstrated to be related to negative health outcomes, such as brittle glycemic control and high risk of acute and chronic complications (12) . Aim of this study was to investigate the behavioral responses during the quarantine due to the COVID-19 pandemic in a cohort of Italian pediatric patients with T1D. From April 15 to May 1, 2020 we conducted a crosssectional survey based on an on-line questionnaire. keywords: children; diabetes; patients; quarantine; t1d cache: cord-346061-pbghgitg.txt plain text: cord-346061-pbghgitg.txt item: #2641 of 2876 id: cord-346062-q0trgj12 author: Robert, René title: Ethical dilemmas due to the Covid-19 pandemic date: 2020-06-17 words: 5719 flesch: 40 summary: Indeed, in addition to the elements linked to the lack of available beds, several factors in the decisionmaking process were sources of concern: reduction of the minimum time necessary to make such occasionally life-or-death decisions, decrease due to containment measures in the essential time to be spent with relatives and pressure from the continuous flow of arriving ICU patients. As another application of the societal concept, it has been proposed to prioritize for ICU care the caregivers who have become critically ill, not due to their intrinsic quality or for so as to reward them, but rather for the possibility, once they are cured, of being returning to the operational caregiving circuit keywords: beds; care; covid-19; decision; family; health; icu; life; members; pandemic; patients; risk cache: cord-346062-q0trgj12.txt plain text: cord-346062-q0trgj12.txt item: #2642 of 2876 id: cord-346205-vqgcq3qt author: Sengillo, Jesse D. title: Importance of Patient Advocacy During the COVID-19 Pandemic date: 2020-09-19 words: 516 flesch: 56 summary: His anxiety about his new diagnosis came with many big questions, like What's next?, Who will take care of me?, and Can I afford treatment? The COVID-19 pandemic has exposed many weaknesses in the US Healthcare System, the most obvious of which include well-documented challenges with resource allocation, social injustices realized from disparate patient outcomes, and as the above case illustrates, a lack of access to specialty care for the uninsured. Now that patients and providers don a mask during visits, the lenses we use fog quickly from breath escaping under the mask. keywords: care; patient cache: cord-346205-vqgcq3qt.txt plain text: cord-346205-vqgcq3qt.txt item: #2643 of 2876 id: cord-346241-w076l97s author: Zhang, Hua title: Dynamic CT assessment of disease change and prognosis of patients with moderate COVID-19 pneumonia date: 2020-09-19 words: 4327 flesch: 45 summary: The analyzed clinical data included the following characteristics: age, sex, exposure history, disease course, laboratory results, symptoms, comorbid conditions, and CT score focusing on the characteristics of pulmonary lesions, including (a) lesion size and distribution characteristics, (b) number of lung segments involved, (c) patterns of the lesion including GGO, consolidation, vascular thickening, bronchial wall thickening, crazy-paving pattern, (d) and other signs associated with the lesion (for example, adjacent pleural thickening, pleural effusion, and mediastinal lymphadenopathy). Each patient had a different magnitude of CT scores; however, they share a consistent quadratic pattern in that the total CT score increased initially and then decreased during the course. keywords: covid-19; days; patients; pneumonia; score; symptoms; thickening cache: cord-346241-w076l97s.txt plain text: cord-346241-w076l97s.txt item: #2644 of 2876 id: cord-346276-1dcp05rd author: Bonfá, Eloisa title: How COVID-19 is changing rheumatology clinical practice date: 2020-11-02 words: 4812 flesch: 48 summary: Patients from the rheumatology unit were transferred to the Orthopaedic Institute, along with patients from almost all specialized clinical wards. Consequently, the ceasing of medication or inappropriate self-management occurred in many patients across the country, resulting in flares of disease in some patients. keywords: care; covid-19; disease; face; hospital; pandemic; patients; research; rheumatology cache: cord-346276-1dcp05rd.txt plain text: cord-346276-1dcp05rd.txt item: #2645 of 2876 id: cord-346288-9to4sdfq author: Haimovich, A. title: Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation date: 2020-05-12 words: 5021 flesch: 39 summary: Between March 1, 2020 and April 27, 2020, there were a total of 1,792 admissions for COVID-19 patients. (a) Quick Covid Severity Index (qCSI) (b) Covid Severity Index (CSI) Figure 4 : Calibration of qCSI and CSI on external validation dataset Consistent with clinical observations, we noted a significant rate of progression to critical respiratory illness within the first 24 hours of hospitalization in COVID-19 patients. keywords: clinical; cohort; covid-19; data; hours; illness; model; patients; qcsi; study; validation; values cache: cord-346288-9to4sdfq.txt plain text: cord-346288-9to4sdfq.txt item: #2646 of 2876 id: cord-346345-jc9bq0zu author: Smith, Colin M title: COVID-19-associated brief psychotic disorder date: 2020-08-11 words: 2612 flesch: 34 summary: Although studies investigating the treatment of COVID-19 psychosis have not been undertaken, treatment of secondary psychosis should be geared towards treating the underlying illness while managing psychotic symptoms with antipsychotics and benzodiazepines at the lowest possible dose. Further, one patient had a comorbid panic disorder, which may lead to heightened vulnerability to psychotic illness, and another was experiencing homelessness and was on 120 mg of methadone for opioid use disorder, again confounding the diagnosis of COVID-19 psychosis. keywords: case; covid-19; history; patients; psychosis; sars; symptoms cache: cord-346345-jc9bq0zu.txt plain text: cord-346345-jc9bq0zu.txt item: #2647 of 2876 id: cord-346389-gbmnoo84 author: Callender, Lauren A. title: The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19 date: 2020-08-11 words: 10050 flesch: 29 summary: Engineering Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Gilead Announces Results From Phase 3 Trial of Remdesivir in Patients With Moderate COVID-19 Available online at Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus Survival after mesenchymal stromal cell therapy in steroidrefractory acute graft-versus-host disease: systematic review and metaanalysis Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia Extraordinary GUrich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment Effective treatment of severe COVID-19 patients with tocilizumab Favorable changes of CT findings in a patient with COVID-19 pneumonia after treatment with tocilizumab Tocilizumab, an anti-IL6 receptor antibody, to treat Covid-19-related respiratory failure: a case report Rapid and severe Covid-19 pneumonia with severe acute chest syndrome in a sickle cell patient successfully treated with tocilizumab Dissection of the effects of jak and btk inhibitors on the functionality of healthy and malignant lymphocytes COVID-19: combining antiviral and anti-inflammatory treatments Baricitinib for COVID-19: a suitable treatment? TH17 responses in cytokine storm of COVID-19: an emerging target of JAK2 inhibitor fedratinib Baricitinib restrains the immune dysregulation in COVID-19 patients. Given that comorbidities are associated with high mortality among COVID-19 patients, a better understanding of the biological mechanisms that underpin this risk are needed to enable development of appropriate preventative and therapeutic strategies. keywords: cases; cells; china; comorbidities; coronavirus; cov-2; covid-19; covid-19 patients; disease; immune; individuals; infection; patients; risk; sars; study; treatment; use cache: cord-346389-gbmnoo84.txt plain text: cord-346389-gbmnoo84.txt item: #2648 of 2876 id: cord-346459-tkt5ldyo author: Jie, Li Shao title: Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan, China date: 2020-11-06 words: 2475 flesch: 39 summary: We explored the risk factors for condition changes in COVID-19 pneumonia patients after admission. Elderly patients are more susceptible to disease changes after COVID-19 pneumonia; COVID-19 pneumonia patients who develop disease changes after admission have higher neutrophil ratios, increased D-dimer levels, chest imaging changes, and glucocorticoid usage. keywords: admission; changes; condition; covid-19; disease; patients; pneumonia cache: cord-346459-tkt5ldyo.txt plain text: cord-346459-tkt5ldyo.txt item: #2649 of 2876 id: cord-346496-crhv0gnt author: Sun, Ying title: Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience date: 2020-04-24 words: 3407 flesch: 45 summary: Histological characteristics in the lung of COVID-19 patients showed diffuse alveolar damage and interstitial lymphocytes infiltrates [11] . key: cord-346496-crhv0gnt authors: Sun, Ying; Dong, Yanli; Wang, Lifeng; Xie, Huan; Li, Baosen; Chang, Christopher; Wang, Fu-sheng title: Characteristics and prognostic factors of disease severity in patients with COVID-19: keywords: covid-19; disease; ferritin; groups; levels; lymphocyte; patients; severity cache: cord-346496-crhv0gnt.txt plain text: cord-346496-crhv0gnt.txt item: #2650 of 2876 id: cord-346539-kxnrf5g5 author: Riggioni, Carmen title: A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2 date: 2020-06-14 words: 15806 flesch: 41 summary: All rights reserved hypersensitivity reactions to drugs may occur more often during the pandemic due to the increased use of drugs and drug interactions, which can result in morbilliform rash, erythroderma, Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia Effect of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China: a modelling study Presumed Asymptomatic Carrier Transmission of COVID-19 Eleven faces of coronavirus disease 2019 The proximal origin of SARS-CoV-2 Phylogenetic network analysis of SARS-CoV-2 genomes Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Distribution of ACE2, CD147, cyclophilins, CD26 and other SARS-CoV-2 associated molecules in various human tissues and immune cells in health and disease SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses Distribution of ACE2, CD147, CD26 and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes The potential danger of suboptimal antibody responses in COVID-19 Resistance to coronavirus infection in amino peptidase N-deficient pigs Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26 ACE1 polymorphism and progression of SARS Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance Antibody responses to SARS-CoV-2 in patients with COVID-19 Long-term coexistence of SARS-CoV-2 with antibody response in COVID-19 patients Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients The Multifaceted B Cell Response in Allergen Immunotherapy COVID-19 Autopsies EAACI position paper on how to classify cutaneous manifestations of drug hypersensitivity Lung eosinophils-A novel virus sink that is defective in asthma? On the other hand, a retrospective study on SARS patients in Hong Kong suggested a better survival rate in patients treated with prednisolone for milder pneumonia or methylprednisolone in more severe cases. keywords: ace2; article; asthma; cases; cells; children; copyright; coronavirus; cov-2; covid-19; covid-19 patients; data; days; disease; figure; human; infection; non; pandemic; patients; reserved; responses; rights; risk; sars; studies; study; transmission; treatment; use cache: cord-346539-kxnrf5g5.txt plain text: cord-346539-kxnrf5g5.txt item: #2651 of 2876 id: cord-346558-u1e0kzmm author: Cattaruzza, Maria Sofia title: Tobacco smoking and COVID-19 pandemic: old and new issues. A summary of the evidence from the scientific literature date: 2020-05-11 words: 3537 flesch: 39 summary: A meta-analysis based on 15 studies and recently published in pre-print (i.e., without having received a peer-review), showed that 63% of COVID-19 patients with COPD had a severe form of the disease compared to 33% among patients without COPD; the relative risk (RR) was 1.9 (95% CI: 1.4-2.4). The hypothesis that nicotine may have a protective role in COVID-19 patients, has also contributed to the debate on the angiotensin-converting enzyme 2 (ACE2). keywords: covid-19; disease; patients; prevalence; smokers; smoking; studies; tobacco cache: cord-346558-u1e0kzmm.txt plain text: cord-346558-u1e0kzmm.txt item: #2652 of 2876 id: cord-346594-tbsxgz43 author: Tang, Sydney C. W. title: Peritoneal dialysis: the ideal bridge from conservative therapy to kidney transplant date: 2020-07-11 words: 3028 flesch: 35 summary: Hemodialysis patients are at risk of bacteremia during the first 90 days of access creation, whereas the risk of peritonitis for PD patients was not different over time. For hemodialysis patients, although there is no concern about treatment related peritonitis, they are susceptible to vascular access infection and appear to be more susceptible to infection than PD patients. keywords: dialysis; hemodialysis; kidney; patients; peritoneal; therapy cache: cord-346594-tbsxgz43.txt plain text: cord-346594-tbsxgz43.txt item: #2653 of 2876 id: cord-346607-1mewok8l author: Oesterle, Tyler S. title: Substance Use Disorders and Telehealth in the COVID-19 Pandemic Era: A New Outlook date: 2020-10-21 words: 4952 flesch: 40 summary: Many longitudinal outcome studies have allowed researchers to look at which aspects of SUD treatment patient have deemed most helpful to their recovery. A number of studies have shown group based treatment by videoconference, both support groups and treatment groups, including those targeting tobacco, alcohol and opioid use disorders have been shown to provide safe intervention, high patient satisfaction and appear to have similar outcomes to in person treatments. keywords: alcohol; care; covid-19; group; health; interventions; patients; sud; telehealth; treatment; use cache: cord-346607-1mewok8l.txt plain text: cord-346607-1mewok8l.txt item: #2654 of 2876 id: cord-346616-kr500kgj author: Qian, Song-Zan title: Clinical Characteristics and Outcomes of Severe and Critical Patients With 2019 Novel Coronavirus Disease (COVID-19) in Wenzhou: A Retrospective Study date: 2020-09-04 words: 2827 flesch: 43 summary: Compared with severe patients, critical patients were older, more likely to exhibit low platelet counts and high blood urea nitrogen, and were in hospital for longer. Compared with severe patients, critical patients were older, more likely to exhibit low platelet counts and high blood urea nitrogen, and were in hospital for longer. keywords: acute; clinical; covid-19; injury; patients; study cache: cord-346616-kr500kgj.txt plain text: cord-346616-kr500kgj.txt item: #2655 of 2876 id: cord-346664-ilebaqx3 author: Rahul title: Non-COVID Surgical Emergency During the Nationwide Lockdown due to Corona Pandemic: a Critical Appraisal date: 2020-08-10 words: 2677 flesch: 50 summary: Through this study, we intend to assess any change in number and pattern of non-COVID surgical emergencies during the lockdown as well as the interventions required. In group 2, an increase (17%) in number of patients was noted. keywords: emergencies; hospital; lockdown; number; patients; study cache: cord-346664-ilebaqx3.txt plain text: cord-346664-ilebaqx3.txt item: #2656 of 2876 id: cord-346721-l6y3n21b author: Vega, Marisa title: From the Trenches: Inpatient Management of COVID-19 in Pregnancy date: 2020-06-15 words: 1441 flesch: 37 summary: but has been noted to be increased in COVID-19 patients, particularly among those requiring 129 admission to the ICU. Obtain ambulatory pulse oximetry measurements (walk test) for stable patients as part of the physical exam -patients may appear deceptively well without exertion • Pocket ultrasounds for biophysical profiles may be useful for COVID-19 patients as an alternative to nonstress tests to limit the number of providers entering the room Step 1: Ask each patient and visitor the following questions. keywords: coronavirus; covid-19; disease; management; patients cache: cord-346721-l6y3n21b.txt plain text: cord-346721-l6y3n21b.txt item: #2657 of 2876 id: cord-346894-iy35298o author: Miranda-Schaeubinger, Monica title: A primer for pediatric radiologists on infection control in an era of COVID-19 date: 2020-07-07 words: 7277 flesch: 37 summary: Standard precautions to minimize the spread of infection within health care facilities from direct contact with contaminations include hand hygiene, use of PPE based on anticipated contact with contaminated material, respiratory hygiene/ cough etiquette, cleaning and disinfection of the environment, and proper handling of patient care equipment and waste [10] . Several studies demonstrated the presence of viral ribonucleic acid (RNA) in 15-53% of stool samples of COVID-19 patients, with persistence of viral RNA in the stool even after respiratory samples became negative. keywords: aerosol; care; contact; covid-19; generating; health; infection; patients; ppe; precautions; procedures; protection; radiology; safety; transmission; use cache: cord-346894-iy35298o.txt plain text: cord-346894-iy35298o.txt item: #2658 of 2876 id: cord-346987-fbqqf00i author: Guo, Yongwen title: Controls of SARS-CoV-2 transmission in orthodontic practice date: 2020-06-05 words: 4679 flesch: 38 summary: Since there may still be asymptomatic patients or patients in the incubation period after resumption of regular activities and a large number of orthodontic patients from a wide spread distribution in need of orthodontic return-visits, all procedures related to the orthodontic practice should be strictly performed with preventive measures to control the potential transmission of SARS-CoV-2. A study from Jordan found that although most Jordanian dentists were aware of COVID-19 symptoms, mode of transmission, infection control and measures in dental clinic, they had limited knowledge of the extra precautionary measures that are essential to protect the dental staffs and other patients from SARS-CoV-2 infection. keywords: coronavirus; cov-2; covid-19; infection; patients; practice; sars; transmission; use cache: cord-346987-fbqqf00i.txt plain text: cord-346987-fbqqf00i.txt item: #2659 of 2876 id: cord-347058-kejcwlng author: Akbari, Hamed title: The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis date: 2020-07-29 words: 3258 flesch: 32 summary: SAA, another important factor capable of improving inflammatory response through activation of chemokine and induction of chemotaxis even at a very low concentration [53] , was found to have elevated circulating levels in severe patients and both were significantly related to COVID-J o u r n a l P r e -p r o o f apoptotic factor The exhaustion of CD8+ T cells in severe patients J o u r n a l P r e -p r o o f may reduce their cellular immune response to SARS-CoV-2. keywords: cases; characteristics; clinical; coronavirus; covid-19; disease; patients; studies; study cache: cord-347058-kejcwlng.txt plain text: cord-347058-kejcwlng.txt item: #2660 of 2876 id: cord-347064-ljd121no author: José, Ricardo J. title: Opportunistic bacterial, viral and fungal infections of the lung date: 2016-05-05 words: 2953 flesch: 27 summary: Opportunistic lung infections are a major cause of morbidity and mortality for patients immunocompromised because of HIV infection, haematological malignancy, aplastic anaemia or chemotherapy treatment, or who are recipients of solid-organ or stem cell transplants, and also can complicate treatment with the new biological therapies for inflammatory conditions. In selected patients, early bronchoscopy increases the yield of microbiological identification of a potential pathogen C Prolonged high-dose glucocorticoids (>20 mg/day for >21 days) predispose to Pneumocystis jirovecii pneumonia (PJP) C Biological agents are associated with specific immune defects that increase the risk of opportunistic lung infections (e.g. tumour necrosis factor-a inhibitors and risk of mycobacterial disease, endemic fungi and Legionella pneumophila; anti-CD20 drugs and mycobacterial disease, cytomegalovirus pneumonitis and PJP keywords: cell; cmv; diagnosis; disease; infection; lung; patients; treatment cache: cord-347064-ljd121no.txt plain text: cord-347064-ljd121no.txt item: #2661 of 2876 id: cord-347091-wbjpa5st author: Davis, Matthew R. title: That Escalated Quickly: Remdesivir's Place in Therapy for COVID-19 date: 2020-07-10 words: 5108 flesch: 40 summary: The Lancet Remdesivir for 5 or 10 days in patients with severe Covid-19 Covid-19 in critically ill patients in the Seattle Region -case series Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 Pneumonia in Wuhan, China Clinical characteristics of coronavirus disease 2019 in China NIH Clinical Trial Shows Remdesivir Accelerates Recovery from Advanced COVID-19 Remdesivir for the treatment of Covid-19-preliminary report Worsening renal function in patients with baseline renal impairment treated with intravenous voriconazole: a systematic review Evaluation of sulfobutylether-beta-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy Gilead Announces Results From Phase 3 Trial of Remdesivir in Patients With Moderate COVID-19. Since the publication of this review, results from two randomized trials evaluating remdesivir for hospitalized patients with COVID-19 were published. keywords: clinical; covid-19; data; day; days; oxygen; patients; remdesivir cache: cord-347091-wbjpa5st.txt plain text: cord-347091-wbjpa5st.txt item: #2662 of 2876 id: cord-347105-my9nioko author: Foster, Carolyn C. title: Integrated Multimodality Telemedicine to Enhance In-Home Care of Infants During the Interstage Period date: 2020-10-20 words: 6785 flesch: 49 summary: Eleven families reported experiencing a technological problem during VV care, but most problems were short-lived. While it is unknown at this time whether reimbursement for VV care will continue in the post-COVID era, the general expansion of VVs across institutions nationally [20, 21] may launch news models of care for patients, including outside of the interstage period. keywords: care; data; families; family; home; interstage; patient; period; program; teleihm; telemedicine; vvs cache: cord-347105-my9nioko.txt plain text: cord-347105-my9nioko.txt item: #2663 of 2876 id: cord-347121-5drl3xas author: Farah, I. title: A global omics data sharing and analytics marketplace: Case study of a rapid data COVID-19 pandemic response platform. date: 2020-09-29 words: 16890 flesch: 43 summary: Third, using the platform as a repository for research data during a peer-review publication process. Publishing research data to an open platform with audit features and data provenance increases the chance of reproducibility and to have reliable assurances for the integrity of the raw data. keywords: access; analysis; covid-19; data; data sharing; datasets; disease; healthcare; information; license; medrxiv; need; new; pandemic; patient; peer; pipelines; platform; preprint; public; research; researchers; review; share; sharing; shivom; user cache: cord-347121-5drl3xas.txt plain text: cord-347121-5drl3xas.txt item: #2664 of 2876 id: cord-347238-yacn6xqk author: Angurala, Mohit title: An Internet of Things Assisted Drone Based Approach to Reduce Rapid Spread of Covid-19 date: 2020-07-02 words: 2367 flesch: 57 summary: The proposed mechanism can effectively improve the treatment process of Covid-19 patients. Doctors and medical staff are most prone to the infection and if their safety is not considered to be important, then it may lead to spread of infection to other patients who suffer from other medical problems and are admitted to the hospital or visits hospital for regular checkups. keywords: covid-19; drone; layer; number; patient; spread cache: cord-347238-yacn6xqk.txt plain text: cord-347238-yacn6xqk.txt item: #2665 of 2876 id: cord-347255-fl9lur4h author: May, Larissa title: Rapid Multiplex Testing for Upper Respiratory Pathogens in the Emergency Department: A Randomized Controlled Trial date: 2019-11-05 words: 4067 flesch: 34 summary: Thus, we conducted a randomized clinical trial of the FilmArray RP vs usual care in ED patients with signs or symptoms of upper respiratory infection or influenza-like illness. We conducted a prospective, patient-oriented, pilot randomized clinical trial of rapid multiplex respiratory pathogen testing (RP test group) vs usual care (usual care or control group) in a level 1 emergency department with limited use of single-organism rapid point-of-care tests at a quaternary referral medical center. keywords: antibiotic; care; influenza; patients; results; study; testing cache: cord-347255-fl9lur4h.txt plain text: cord-347255-fl9lur4h.txt item: #2666 of 2876 id: cord-347263-ci6mv72z author: Berekashvili, k. title: Etiologic Subtypes of Ischemic Stroke in SARS-COV-2 Virus patients date: 2020-05-08 words: 2974 flesch: 51 summary: The median age of large vessel stroke patients was 46 years, the youngest being in the twenties. Methods: Over the last 6 weeks, data from four centers in New York City were collected to review the possible ischemic stroke types seen in COVID-19 positive patients. keywords: author; covid-19; medrxiv; patients; preprint; review cache: cord-347263-ci6mv72z.txt plain text: cord-347263-ci6mv72z.txt item: #2667 of 2876 id: cord-347268-vb6z0hzb author: Wicclair, Mark R. title: Is conscientious objection incompatible with a physician’s professional obligations? date: 2008-08-28 words: 6532 flesch: 36 summary: As this statement indicates, they reject the implausible absolutist view that the healing-related interests of patients always trump physician interests. Moreover, it is overly simplistic to talk about comparing a conception of professional obligations that permits conscientious objection with one that does not, for there are a variety of conditions that might be placed on conscientious objection, such as requirements to notify in advance and refer. keywords: conception; healing; medical; medicine; obligations; physicians; professional; services cache: cord-347268-vb6z0hzb.txt plain text: cord-347268-vb6z0hzb.txt item: #2668 of 2876 id: cord-347277-8bmcd22v author: Huang, Ying hui title: The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods date: 2020-04-10 words: 3802 flesch: 51 summary: key: cord-347277-8bmcd22v authors: Huang, Ying hui; Meng, Si jun; Zhang, Yi; Wu, Shui sheng; Zhang, Yu; Zhang, Ya wei; Ye, Yi xiang; Wei, Qi feng; Zhao, Nian gui; Jiang, Jian ping; Ji, Xiao ying; Zhou, Chun xia; Zheng, Chao; Zhang, Wen; Xie, Li zhong; Hu, Yong chao; He, Jian quan; Chen, Jian; Wang, Wang yue; Zhang, Chang hua; Cao, Liming; Xu, Wen; Lei, Yunhong; Jian, Zheng hua; Hu, Wei ping; Qin, Wen juan; Wang, Wan yu; He, Yu long; Xiao, Hang; Zheng, Xiao fang; Hu, Yi Qun; Pan, Wen Sheng; Cai, Jian feng title: The respiratory sound features of COVID-19 patients fill gaps between clinical data and screening methods date: 2020-04-10 journal: nan DOI: 10.1101/2020.04.07.20051060 sha: doc_id: 347277 cord_uid: 8bmcd22v Background: The 2019 novel coronavirus (COVID-19) has continuous outbreaks around the world. This study intends to leverage a remote electronic stethoscope to collect the lung auscultation characteristics of COVID-19 patients, which makes up the lack of existing COVID-19 clinical data. keywords: 0(0; auscultation; breath; covid-19; lung; patients; results; sounds; time cache: cord-347277-8bmcd22v.txt plain text: cord-347277-8bmcd22v.txt item: #2669 of 2876 id: cord-347280-jpwf55l6 author: Skevaki, Chrysanthi title: Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus date: 2020-06-21 words: 3076 flesch: 30 summary: Although patients with severe COVID-19 seem to have higher rates of liver dysfunction, it is reassuring that the levels of ALT, AST, TBIL, GGT in COVID-19 patients were not significantly different in compared with hospitalized community-acquired pneumonia patients and even the median or average transaminase level in severe COVID-19 patients was lower than twice upper reference limit 4, 36, 37 . key: cord-347280-jpwf55l6 authors: Skevaki, Chrysanthi; Fragkou, Paraskevi C.; Cheng, Chongsheng; Xie, Min; Renz, Harald title: Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus date: 2020-06-21 journal: J Infect DOI: 10.1016/j.jinf.2020.06.039 sha: doc_id: 347280 cord_uid: jpwf55l6 A subgroup of COVID-19 patients develop very severe disease with requirement for ICU treatment, ventilation, and ECMO therapy. keywords: cases; china; covid-19; disease; levels; patients; risk; sars; study cache: cord-347280-jpwf55l6.txt plain text: cord-347280-jpwf55l6.txt item: #2670 of 2876 id: cord-347289-3yi5tz04 author: Poon, L. . C. title: ISUOG Interim Guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium: information for healthcare professionals – an update date: 2020-06-01 words: 8045 flesch: 35 summary: Although not yet validated in COVID-19 pregnant patients, a modified early obstetric warning score (MEOWS) can be used to enable early recognition of critical illness 50, 51 . Miscarried embryos/fetuses and placentae of COVID-19 pregnant women should be treated as infectious tissues and should be disposed of appropriately. keywords: care; cases; coronavirus; cov-2; covid-19; delivery; disease; infection; obstetric; patients; pregnancy; pregnant; risk; sars; transmission; women cache: cord-347289-3yi5tz04.txt plain text: cord-347289-3yi5tz04.txt item: #2671 of 2876 id: cord-347293-fp8phk0p author: Kearns, Donovan G. title: Assessing The Risk of Adalimumab Use For Hidradenitis Suppurativa During The COVID-19 Pandemic date: 2020-07-28 words: 614 flesch: 42 summary: With limited real-life data from COVID-19 infection in patients with hidradenitis suppurativa (HS) receiving adalimumab, we can use previous drug trials to extrapolate the potential risk to patients, based upon the change in infection rate when compared to placebo. Adalimumab, a tumor necrosis factor alpha (TNF-α) antagonist, is the only FDA approved biologic treatment for patients >12 years with for moderate to severe HS. This is consistent with a recent case series documenting mild, uncomplicated disease in a small cohort of HS patients receiving adalimumab. keywords: adalimumab; patients cache: cord-347293-fp8phk0p.txt plain text: cord-347293-fp8phk0p.txt item: #2672 of 2876 id: cord-347351-emdj66vj author: Kampf, Günter title: Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2 date: 2020-09-18 words: 10293 flesch: 41 summary: [Chinese journal of preventive medicine Indirect Virus Transmission in Cluster of COVID-19 Cases Familial cluster of COVID-19 infection from an asymptomatic Potential Presymptomatic Transmission of SARS-CoV-2 Asymptomatic and Human-to-Human Transmission of SARS-CoV-2 in a 2-Family Cluster Presumed Asymptomatic Carrier Transmission of COVID-19 The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) Covid-19: four fifths of cases are asymptomatic, China figures indicate COVID-19 transmission through asymptomatic carriers is a challenge to containment. Table III summarizes the frequency and magnitude of SARS-CoV-2 viral RNA loads in respiratory tract samples obtained from COVID-19 patients. keywords: air; asymptomatic; cases; coronavirus; cov-2; covid-19; detection; disease; infection; patients; respiratory; rna; samples; sars; study; surfaces; transmission cache: cord-347351-emdj66vj.txt plain text: cord-347351-emdj66vj.txt item: #2673 of 2876 id: cord-347375-5ucemm87 author: Sazzad, Hossain M.S. title: Nipah Virus Infection Outbreak with Nosocomial and Corpse-to-Human Transmission, Bangladesh date: 2013-02-17 words: 4336 flesch: 50 summary: The duration between onset of illness of the physician and his contact with confirmed NiV case-patients was beyond the range of the 6-to 11day incubation period for NiV (12, 17) . Among 7 persons with confirmed sporadic cases, 6 died, including a physician who had physically examined encephalitis patients without gloves or a mask. keywords: bangladesh; case; contact; illness; infection; niv; outbreak; patients; transmission cache: cord-347375-5ucemm87.txt plain text: cord-347375-5ucemm87.txt item: #2674 of 2876 id: cord-347414-t88654wo author: Peng, Mian title: Successful management of seven cases of critical COVID-19 with early noninvasive-invasive sequential ventilation algorithm and bundle pharmacotherapy date: 2020-08-06 words: 2754 flesch: 43 summary: Thus, we concluded that good outcomes for patients with critical COVID-19 can be achieved with early noninvasive–invasive sequential ventilation and bundle pharmacotherapy. In December of 2019, a cluster of patients with pneumonia of unknown cause was linked to transmission at a seafood wholesale market in Wuhan, China. keywords: coronavirus; covid-19; days; patients; pneumonia; sars cache: cord-347414-t88654wo.txt plain text: cord-347414-t88654wo.txt item: #2675 of 2876 id: cord-347607-ydbyonbg author: Spagnuolo, Rocco title: COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey date: 2020-08-13 words: 3727 flesch: 43 summary: J. Crohn's Colitis 2020 Maintaining the Quality Standards of Care for Inflammatory Bowel Disease Patients During the COVID-19 Pandemic Protection of 318 Inflammatory Bowel Disease Patients from the Outbreak and Rapid Spread of COVID-19 Infection in Wuhan Uneventful course in IBD patients during SARS-CoV-2 outbreak in northern Italy IOIBD Update on COVID19 for Patients with Crohn's Disease and Ulcerative Colitis Withdrawal of immunosuppressant or biologic therapy for patients with quiescent Crohn's disease DOP064 ECCO expert consensus and topical review on treatment exit strategies in inflammatory bowel disease. At date, several ongoing studies evaluate management of IBD patients during pandemic reporting as CD and UC does not increase risk of infection keywords: anxiety; covid-19; disease; ibd; knowledge; level; patients cache: cord-347607-ydbyonbg.txt plain text: cord-347607-ydbyonbg.txt item: #2676 of 2876 id: cord-347696-rsjwp0b3 author: Roberts, Haydn title: Reply to the Letter to the Editor: Can Sural Fasciocutaneous Flaps Be Effective in Patients Older Than 65? date: 2020-06-01 words: 317 flesch: 56 summary: Clin Ortho Relat Res Can sural fasciocutaneous flaps be effective in patients older than 65? Can Sural Fasciocutaneous Flaps Be Effective in Patients Older Than 65? Before the coronavirus disease 2019 (COVID-19) pandemic, the goal was merely to avoid the risks of a general anesthetic in older patients. keywords: patients cache: cord-347696-rsjwp0b3.txt plain text: cord-347696-rsjwp0b3.txt item: #2677 of 2876 id: cord-347697-uz0i6wfp author: McLean, Ross C. title: A single-centre observational cohort study to evaluate volume and severity of emergency general surgery admissions during the COVID-19 pandemic: is there a “lockdown” effect? date: 2020-09-12 words: 3908 flesch: 39 summary: [40] [41] in these patients are J o u r n a l P r e -p r o o f essential, particularly if there are concerns of ischaemic bowel or perforations as these are significant predictors of mortality for emergency general surgical patients. However, the 'gatekeeper' effect is likely to be minimal in this study as there were no significant differences in management of surgical patients before or after lockdown, and our findings are replicated in different surgical specialities and in different healthcare systems keywords: covid-19; emergency; lockdown; mortality; patients; study; surgical cache: cord-347697-uz0i6wfp.txt plain text: cord-347697-uz0i6wfp.txt item: #2678 of 2876 id: cord-347752-2ejnva4u author: Mrabti, Hind title: Cancer management challenge in a developing country in COVID-19 pandemic: reflection of a group of Moroccan oncologists date: 2020-06-25 words: 4586 flesch: 35 summary: The official French guidelines to protect patients with cancer against SARS-CoV-2 infection guidelines for cancer patients during COVID-19 pandemic Management of ovarian cancer during the COVID-19 pandemic Caring for patients with cancer during the COVID-19 outbreak in Italy The Lebanese Society of Medical Oncology (LSMO) statement on the care of patients with cancer during the COVID-19 pandemic • Lebanese guidelines of cancer management during COVID-19 pandemic Preparing African anticancer centres in the COVID-19 outbreak Impact of cancer on Muslim patients in Morocco Factors associated with the time to first palliative care consultation in Lebanese cancer patients Caring for patients with cancer in the COVID-19 era European cancer centers management during COVID-19 pandemic COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting Continued treatment effect of zoledronic acid dosing every 12 vs 4 weeks in women with breast cancer metastatic to bone Controversies about COVID-19 and anticancer treatment with immune checkpoint inhibitors Managing oncology services during a major coronavirus outbreak: lessons from the Saudi Arabia experience •• Describes oncology department management during COVID-19 pandemic The Moroccan expert panel of oncologists, proposed these recommendations for the management of cancer patients which had to take into account several parameters: • Keep cancer patients away from the risk of contracting the coronavirus: which could be dangerous for them but also for their family since they are immunocompromised and are more likely to contract it and therefore transmit it to those around them; • Take into account the short-term prognosis of the disease, especially for metastatic diseases; • Take into account the long-term prognosis for patients treated in a curative situation; • Protect healthcare workers, families of cancer patients. keywords: cancer; care; covid-19; health; management; patients; risk; situation; treatment cache: cord-347752-2ejnva4u.txt plain text: cord-347752-2ejnva4u.txt item: #2679 of 2876 id: cord-347905-w0fnc43a author: Schwartz, Joseph S. title: Diseases of the nasal cavity date: 2019-10-08 words: 10697 flesch: 18 summary: Olfactory loss arising in a postviral setting is more often described as partial (hyposmia) than complete (anosmia) compared to other common etiologies of disturbed olfaction (Cain et al., 1988; Deems et al., 1991; Wrobel and Leopold, 2004a) . Olfactory loss has also been described in association with general anesthesia, although the exact mechanism of this relationship remains unclear (Adelman, 1995) . keywords: crs; disease; dysfunction; endoscopic; et al; function; loss; nasal; olfaction; olfactory; outcomes; patients; rhinosinusitis; sinonasal; sinus; smell; study; surgery cache: cord-347905-w0fnc43a.txt plain text: cord-347905-w0fnc43a.txt item: #2680 of 2876 id: cord-348051-o1hxoasp author: Upadhyaya, Gaurav K. title: Challenges and strategies in management of osteoporosis and fragility fracture care during COVID-19 pandemic date: 2020-06-02 words: 3392 flesch: 40 summary: Traditional radiology can possibly diagnose osteoporosis fractures in the most commonly involved sites (spine, pelvis, distal radius, proximal femur and humerus,). Further these patients require short hospitalization for observation during IV infusion which will be difficult in current scenario when the hospitals are flooded with COVID-19 patients and the transportation is limited in many areas. keywords: bone; covid-19; fractures; fragility; hip; management; osteoporosis; pandemic; patients; risk cache: cord-348051-o1hxoasp.txt plain text: cord-348051-o1hxoasp.txt item: #2681 of 2876 id: cord-348130-t9tysvr8 author: Cho, Sung-Yeon title: Infectious complications after hematopoietic stem cell transplantation: current status and future perspectives in Korea date: 2018-02-27 words: 9721 flesch: 31 summary: A prospective study on the predictive value of plasma BK virus-DNA load for hemorrhagic cystitis in pediatric patients after stem cell transplantation Late-onset hemorrhagic cystitis in children after hematopoietic stem cell transplantation for thalassemia and sickle cell anemia: a prospective evaluation of polyoma (BK) virus infection and treatment with cidofovir BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: treatment response and evidence for nosocomial transmission Treatment of BK virus-associated hemorrhagic cystitis in pediatric hematopoietic stem cell transplant recipients with cidofovir: a single-center experience Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant Low-dose cidofovir in the treatment of symptomatic BK virus infection in patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis of an algorithmic approach Treatment of BK virus-associated hemorrhagic cystitis with low-dose intravenous cidofovir in patients undergoing allogeneic hematopoietic cell transplantation Low-dose cidofovir treatment of BK virus-associated hemorrhagic cystitis in recipients of hematopoietic stem cell transplant Brincidofovir (CMX001) inhibits BK polyomavirus replication in primary human urothelial cells Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients Respiratory viral infections in transplant and oncology patients Utilization of the respiratory virus multiplex reverse transcription-polymerase chain reaction test for adult patients at a Korean tertiary care center Lower respiratory tract diseases caused by common respiratory viruses among stem cell transplantation recipients: a single center experience in Korea Management of RSV infections in adult recipients of hematopoietic stem cell transplantation ECIL-4): guidelines for diagnosis and treatment of human respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome Outcome of pandemic H1N1 infections in hematopoietic stem cell transplant recipients Risk factors for pneumonia in immunocompromised patients with influenza European guidelines for prevention and management of influenza in hematopoietic stem cell transplantation and leukemia patients: summary of ECIL-4 Upper and lower respiratory tract infections by human enterovirus and rhinovirus in adult patients with hematological malignancies Rhinovirus as a cause of fatal lower respiratory tract infection in adult stem cell transplantation patients: a report of two cases BCSH/BSBMT/ UK clinical virology network guideline: diagnosis and management of common respiratory viral infections in patients undergoing treatment for haematological malignancies or stem cell transplantation Guideline on the prevention and control of seasonal influenza in healthcare setting Clinical practice guideline for antiviral treatment and chemoprophylaxis of seasonal influenza Community acquired respiratory virus infections in cancer patients-guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology Immunodeficiency scoring index to predict poor outcomes in hematopoietic cell transplant recipients with RSV infections Palivizumab treatment of respiratory syncytial virus infection after allogeneic hematopoietic stem cell transplantation Oral GS-5806 activity in a respiratory syncytial virus challenge study Severe influenza treatment guideline The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: high incidence compared with general population Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: a 10-year nationwide study Infections caused by mycobacterium tuberculosis in recipients of hematopoietic stem cell transplantation Tuberculosis in hematopoietic stem cell transplant recipients in Korea Vaccinations in patients with hematological malignancies A comprehensive review of immunization practices in solid organ transplant and hematopoietic stem cell transplant recipients Vaccination of hematopoietic stem cell transplantation recipients: perspective in Korea BKV-associated hemorrhagic cystitis is predominant in allogeneic HSCT patients, and BKV-associated nephropathy in KT patients. keywords: allogeneic; cell; cmv; diseases; gvhd; hematopoietic; hsct; infection; korea; patients; prophylaxis; recipients; risk; stem; study; transplantation; treatment; virus cache: cord-348130-t9tysvr8.txt plain text: cord-348130-t9tysvr8.txt item: #2682 of 2876 id: cord-348172-q3zcn5pf author: Poli, Daniela title: Managing anticoagulation in the COVID-19 era between lockdown and reopening phases date: 2020-06-08 words: 1327 flesch: 31 summary: Patients on anticoagulant treatment are constantly increasing, with a prevalence of nearly 2% of the total population [1] . Anticoagulation Clinics (ACs) routinely manage thousands of patients taking anticoagulants, either vitamin K antagonists (VKAs), direct oral anticoagulants (DOACs), or parenteral drugs. To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/. FADOI (Federation of Associations of Hospital Doctors on Internal Medicine), SISET (Italian Society for the Study of Haemostasis and Thrombosis) (2017) Italian intersociety consensus on DOAC use in internal medicine The effect of management models on thromboembolic and bleeding rates in anticoagulated patients: an ecological study European Centre for Disease Prevention and Control (2020) Infection prevention and control for COVID-19 in healthcare settingsthird update Lip GYH (2020) cardiovascular considerations for patients, health care workers, and health systems during the coronavirus disease 2019 (COVID-19) pandemic Direct oralanticoagulant plasma levels striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents. keywords: anticoagulation; covid-19; patients; treatment cache: cord-348172-q3zcn5pf.txt plain text: cord-348172-q3zcn5pf.txt item: #2683 of 2876 id: cord-348202-6we8e60b author: Drake, Daniel H. title: Echo in Pandemic: Front Line Perspective, Expanding Role of Ultrasound and Ethics of Resource Allocation date: 2020-04-10 words: 4115 flesch: 35 summary: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) associated acute cardiomyopathy is common in critical care patients and is associated with a high mortality. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) associated acute cardiomyopathy is common in critical care patients and is associated with a high mortality. keywords: care; covid-19; disease; health; lung; pandemic; patients; ultrasound; ventilation cache: cord-348202-6we8e60b.txt plain text: cord-348202-6we8e60b.txt item: #2684 of 2876 id: cord-348364-jb0lvhq5 author: Rehman, Tyler title: Spontaneous Pneumothorax in an Elderly Patient With Coronavirus Disease (COVID-19) Pneumonia date: 2020 words: 1328 flesch: 41 summary: As of June 2020, few cases of nonintubated patients developing pneumothorax had been documented. Spontaneous pneumothorax is usually attributed to a bleb rupture. keywords: covid-19; patient; pneumonia; pneumothorax cache: cord-348364-jb0lvhq5.txt plain text: cord-348364-jb0lvhq5.txt item: #2685 of 2876 id: cord-348422-werg9ofa author: Shamsah, Mohammed A title: Right atrial thrombus in a patient with COVID-19 pneumonia: a case report date: 2020-09-04 words: 1888 flesch: 37 summary: Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy The stimulation of thrombosis by hypoxia COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure Coagulopathy and antiphospholipid antibodies in patients with Covid-19 Viral infections and antiphospholipid antibodies Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy ISTH interim guidance on recognition and management of coagulopathy in COVID-19 Hypercoagulability of COVID-19 patients in intensive care unit. Expert consensus has recommended prophylactic anticoagulation in COVID-19 patients due to the risk of thrombo-embolism. keywords: covid-19; embolism; patients; pneumonia; pulmonary; treatment cache: cord-348422-werg9ofa.txt plain text: cord-348422-werg9ofa.txt item: #2686 of 2876 id: cord-348423-zq86ms8w author: Louvardi, Maya title: Mental health in chronic disease patients during the COVID-19 quarantine in Greece date: 2020-06-29 words: 3666 flesch: 36 summary: The aims of the study were the following: (a) to search for an effect of quarantine duration on anxiety, depression, somatization, and distress of chronic disease patients and (b) to investigate differences between healthy individuals and patients with chronic diseases in anxiety, depression, somatization, and distress during the COVID-19 quarantine. key: cord-348423-zq86ms8w authors: Louvardi, Maya; Pelekasis, Panagiotis; Chrousos, George P.; Darviri, Christina title: Mental health in chronic disease patients during the COVID-19 quarantine in Greece date: 2020-06-29 journal: Palliative & supportive care DOI: 10.1017/s1478951520000528 sha: doc_id: 348423 cord_uid: zq86ms8w OBJECTIVE: To investigate the effect of the time spent on quarantine on distress, anxiety, depression, and somatization of chronic disease patients during the COVID-19 quarantine in Greece and the differences in these parameters between healthy individuals and chronic disease patients. keywords: chronic; disease; individuals; patients; quarantine; study cache: cord-348423-zq86ms8w.txt plain text: cord-348423-zq86ms8w.txt item: #2687 of 2876 id: cord-348430-8xk4dt7t author: Bragazzi, Nicola Luigi title: COVID‐19 knowledge prevents biologics discontinuation: Data from an Italian multicenter survey during RED‐ZONE declaration date: 2020-05-28 words: 1954 flesch: 26 summary: key: cord-348430-8xk4dt7t authors: Bragazzi, Nicola Luigi; Riccò, Matteo; Pacifico, Alessia; Malagoli, Piergiorgio; Kridin, Khalaf; Pigatto, Paolo; Damiani, Giovanni title: COVID‐19 knowledge prevents biologics discontinuation: Data from an Italian multicenter survey during RED‐ZONE declaration date: 2020-05-28 journal: Dermatol Ther DOI: 10.1111/dth.13508 sha: doc_id: 348430 cord_uid: 8xk4dt7t SARS‐CoV‐2 become pandemics and there is still a dearth of data about its the potentially among dermatological patients under biologics. To the best of our knowledge, there is a dearth of data concerning the COVID-19 perceptions of dermatological patients under biologics, a therapy traditionally associated to an increased risk of infections. keywords: biologics; covid-19; disease; knowledge; patients; psoriasis cache: cord-348430-8xk4dt7t.txt plain text: cord-348430-8xk4dt7t.txt item: #2688 of 2876 id: cord-348458-dwj90mbq author: Narula, Nupoor title: Cardiology Practice and Training Post-COVID-19: Achieving “Normalcy” After Disruption date: 2020-06-22 words: 1871 flesch: 45 summary: While none of us have 163 absolute foresight, we must learn from the harsh lessons faced and plan for 164 medical changes, including the deluge of cardiac care patients that will fill our 165 clinics, flexibility of FIT education to support cardiovascular training, and 166 continued integration of clinical science and technology. The bipartisan CARES legislation has 79 allocated at least 50 billion dollars to support hospital systems and health care 80 providers 11 , and private physician offices and faculty practices are eligible to 81 apply for several loan-based programs, including the Paycheck Protection 82 Program and Emergency Economic Injury Disaster Loans. keywords: care; covid-19; disease; health; pandemic; patients cache: cord-348458-dwj90mbq.txt plain text: cord-348458-dwj90mbq.txt item: #2689 of 2876 id: cord-348501-8cvtqj7w author: Beyzaee, Amir Mohammad title: Rituximab as the treatment of pemphigus vulgaris in the COVID‐19 pandemic era: A narrative review date: 2020-10-20 words: 2513 flesch: 33 summary: Although evidence for treating PV patients with rituximab in COVID-19 pandemic is limited, and outcomes of MS patients taking rituximab was controversial, until sufficient evidence as a guideline for pemphigus and COVID-19 treatment is available, we advocate caution commencing rituximab for pemphigus patients and adherence to basic principles of infection control and decreasing drug induced immunosuppression as possible. 28 High amount of IL-6, a strong factor related to mortality in COVID-19 patients, is seen in patients given rituximab and secukinumab, that can be due to the failure of rituximab and secukinumab to modulate IL-6. keywords: covid-19; patients; pemphigus; rituximab; treatment cache: cord-348501-8cvtqj7w.txt plain text: cord-348501-8cvtqj7w.txt item: #2690 of 2876 id: cord-348535-tvs1snq8 author: Ottaviani, Silvia title: What is the best drug to treat COVID-19? The need for randomized controlled trials date: 2020-05-19 words: 1412 flesch: 39 summary: For example, we have observed 11 that use of baricitinib for 10 days is associated with viral rebound in nasopharyngeal swabs in rapidly recovered and discharged patients, and thus have recommended longer use in the large randomised studies in which it is included, and we suggest again that comparisons between different therapies or placebo are likely to yield more informative results than randomised studies comparing 10 days of intravenous remdesevir with 5 days (https://benevolent.ai/news/potential-treatment-for-covid-19-identified-by-benevolentai-usingartificial-intelligence-enters-clinical-testing And https://investor.lilly.com/news-releases/news-release-details/lilly-begins-clinical-testingtherapies-covid-19). Baseline criteria between the 3 groups were well-matched (a criticism of one of the hydroxychloroquine randomised studies is this was not the case 13 ) and follow up was appropriate. keywords: covid-19; patients; studies; study cache: cord-348535-tvs1snq8.txt plain text: cord-348535-tvs1snq8.txt item: #2691 of 2876 id: cord-348570-plds5kbn author: Buneviciene, Inesa title: Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis date: 2020-10-20 words: 5440 flesch: 35 summary: The effects of mindfulness-based stress reduction on psychosocial outcomes and quality of life in early-stage breast cancer patients: a randomized trial Digital Phenotyping in Patients with Spine Disease: A Novel Approach to Quantifying Mobility and Quality of Life 3 Digital Phenotyping: A Novel Method for Quality of Life Assessment in Patients with Brain Tumors Opportunities and challenges in the collection and analysis of digital phenotyping data Cognitive Behavior Therapy for Patients With Cancer The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses Cognitive behavioral therapy techniques for distress and pain in breast cancer patients: a meta-analysis Efficacy of Blended Cognitive Behavior Therapy for High Fear of Recurrence in Breast, Prostate, and Colorectal Cancer Survivors: The SWORD Study, a Randomized Controlled Trial Using cognitive behavioural therapy in practice: qualitative study of family physicians' experiences There's an App for That: Information Technology Applications for Cognitive Behavioral Practitioners Review of cognitive behavioural therapy mobile apps using a reference architecture embedded in the patient-provider relationship Digital health and perioperative care The Functional Assessment of Cancer Therapy scale: development and validation of the general measure Life satisfaction in young adults with cancer and the role of sociodemographic, medical, and psychosocial factors: Results of a longitudinal study Perceived social support and its impact on depression and health-related quality of life: a comparison between cancer patients and general population The Relationship Between Coping Strategies, Quality of Life, and Mood in Patients with Incurable Cancer Longitudinal Effects of Social Support and Adaptive Coping on the Emotional Well-Being of Survivors of Localized Prostate Cancer Coping response following a diagnosis of breast cancer: A systematic review Management of cancer pain: ESMO Clinical Recommendations The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology Choosing between the EORTC QLQ-C30 and FACT-G for measuring health-related quality of life in cancer clinical research: issues, evidence and recommendations General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States The MOS 36-item short-form health survey (SF-36). key: cord-348570-plds5kbn authors: Buneviciene, Inesa; Mekary, Rania A.; Smith, Timothy R.; Onnela, Jukka-Pekka; Bunevicius, Adomas title: Can mHealth interventions improve quality of life of cancer patients? keywords: breast; cancer; control; group; hrqol; interventions; life; mhealth; patients; quality; studies; study cache: cord-348570-plds5kbn.txt plain text: cord-348570-plds5kbn.txt item: #2692 of 2876 id: cord-348578-chfb4i15 author: Bulman, Julie C. title: Transitioning the IR Clinic to Telehealth: A Single-Center Experience during the COVID-19 Pandemic date: 2020-06-30 words: 3331 flesch: 40 summary: There has been no guidance in the literature regarding the implementation of telehealth visits in interventional radiology (IR). In its intended form, Medicare telehealth visits represent the equivalent of an in-person clinic appointment or consultation and were previously conducted via video platform only (5) . keywords: clinic; patient; physician; services; telehealth; time; trainee; video; visit cache: cord-348578-chfb4i15.txt plain text: cord-348578-chfb4i15.txt item: #2693 of 2876 id: cord-348672-e34103b1 author: Zhang, Jiaqi title: Postoperative Short-term Outcomes Between Sublobar Resection and Lobectomy in Patients with Lung Adenocarcinoma date: 2020-10-01 words: 3251 flesch: 37 summary: Considering that adenocarcinoma dominated a great part in lung cancer, the purpose of this study was to retrospectively analyze the short-term outcomes of lung adenocarcinoma patients who underwent different lung resections. Early diagnosis and early treatment significantly benefit the overall survival of lung cancer patients. keywords: cancer; lobectomy; lung; p=0.000; patients; postoperative; resection; sublobar cache: cord-348672-e34103b1.txt plain text: cord-348672-e34103b1.txt item: #2694 of 2876 id: cord-348755-2g5gi1du author: Chow, D. S. title: Development and External Validation of a Prognostic Tool for COVID-19 Critical Disease date: 2020-05-11 words: 2862 flesch: 37 summary: The purpose of this study is to develop and externally validate a prognostic model/clinical tool for predicting COVID-19 critical disease at presentation to medical care. Methods: This is a retrospective study of a prognostic model for the prediction of COVID-19 critical disease where critical disease was defined as ICU admission, ventilation, and/or death. keywords: covid-19; critical; disease; model; patients; preprint cache: cord-348755-2g5gi1du.txt plain text: cord-348755-2g5gi1du.txt item: #2695 of 2876 id: cord-348813-v1sdodz9 author: Kefale, Belayneh title: Prevalence and Risk Factors of Thromboembolism among Patients With Coronavirus Disease-19: A Systematic Review and Meta-Analysis date: 2020-10-19 words: 3592 flesch: 35 summary: Deep vein thrombosis and pulmonary embolism Epidemiology of venous thromboembolism Incidence of and mortality from venous thromboembolism in a real-world population: the Q-VTE Study Cohort Morbidity, mortality and costs associated with venous thromboembolism in hospitalized patients with cancer Thromboprophylaxis and mortality among patients who developed venous thromboembolism in seven major hospitals in Saudi Arabia Direct medical costs of venous thromboembolism and subsequent hospital readmission rates: an administrative claims analysis from 30 managed care organizations Deep vein thrombosis in Europe-health-related quality of life and mortality Health-related quality of life and mortality in patients with pulmonary embolism: a prospective cohort study in seven European countries Economic burden of venous thromboembolism: a systematic review Global burden of thrombosis: epidemiologic aspects 30-year mortality after venous thromboembolism: a population-based cohort study The economic burden of incident venous thromboembolism in the United States: a review of estimated attributable healthcare costs Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Role of D-dimers in diagnosis of venous thromboembolism Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients Current practice of antibiotic prophylaxis for surgical fixation of closed long bone fractures: a survey of 297 members of the orthopaedic trauma association Prevalence and risk factors of thromboembolism among patients with COVID-19: a protocol for a systematic review and meta-analysis New guidelines for antimicrobial prophylaxis in surgery DVT incidence and risk factors in critically ill patients with COVID-19 Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study Venous thrombosis among critically Ill patients with coronavirus disease 2019 (COVID-19) High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Extremely high incidence of lower extremity deep venous thrombosis in 48 patients with severe COVID-19 in Wuhan Incidence of venous thromboembolism in hospitalized patients with COVID-19 Risk assessment of venous thromboembolism and bleeding in COVID-19 patients Pulmonary embolism in hospitalised patients with COVID-19 Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography Acute pulmonary embolism in COVID-19 patients on CT angiography and relationship to D-dimer levels Pulmonary embolism in patients with Covid-19 pneumonia Deep vein thrombosis in hospitalized patients with COVID-19 in Wuhan Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels keywords: covid-19; events; factors; patients; prevalence; risk; studies; thromboembolism cache: cord-348813-v1sdodz9.txt plain text: cord-348813-v1sdodz9.txt item: #2696 of 2876 id: cord-348855-lnltoj1n author: Iannaccone, Giulia title: Weathering the Cytokine Storm in COVID-19: Therapeutic Implications date: 2020-06-29 words: 4681 flesch: 28 summary: For these reasons, the WHO does not recommend routine administration of CS in COVID-19 patients outside of clinical trials; their adjunctive use may be indicated on an individual basis or unless indicated for other conditions, such as chronic obstructive pulmonary disease, asthma, and septic shock [23] . Moreover, in 2 small retrospective studies of COVID-19 patients in China suffering from severe lung injury it was observed that the use of this agent could provide significant clinical improvement without important side effects [38, 39] . keywords: coronavirus; covid-19; cytokine; disease; infection; patients; response; sars; syndrome; therapy; treatment; use cache: cord-348855-lnltoj1n.txt plain text: cord-348855-lnltoj1n.txt item: #2697 of 2876 id: cord-348879-opzkodt7 author: Nune, A. title: Challenges in delivering rheumatology care during COVID-19 pandemic date: 2020-07-25 words: 2618 flesch: 43 summary: There is little data available about the effect of novel SARS-CoV-2 upon rheumatology patients with autoimmune conditions. Prompt delivery of consistent, clear, unambiguous and specific information directed to rheumatology patients using effective means of communication will reduce helpline queries to a manageable level. keywords: care; consultations; covid-19; face; pandemic; patients; rheumatology cache: cord-348879-opzkodt7.txt plain text: cord-348879-opzkodt7.txt item: #2698 of 2876 id: cord-348881-w0moe21t author: Creel-Bulos, Christina title: Acute Cor Pulmonale in Critically Ill Patients with Covid-19 date: 2020-05-06 words: 633 flesch: 36 summary: Myocardial dysfunction and hypercoagulability have been reported in patients with Covid-19; however, the true incidence and clinical implications of these events remain unclear. Pulmonary embolism in intensive care unit: predictive factors, clinical manifestations and outcome Management of patients with high-risk pulmonary embolism: a narrative review Correspondence Copyright © 2020 Massachusetts Medical Society Emory University Atlanta, GA milad . keywords: acute; covid-19; patients cache: cord-348881-w0moe21t.txt plain text: cord-348881-w0moe21t.txt item: #2699 of 2876 id: cord-348975-plne3xlz author: Wagner, Tyler title: Augmented curation of clinical notes from a massive EHR system reveals symptoms of impending COVID-19 diagnosis date: 2020-07-07 words: 4950 flesch: 33 summary: Expanding beyond one institution's COVID-19 diagnostic testing and clinical care to the EHR databases of other academic medical centers and health systems will provide a more holistic view of clinical symptoms enriched in COVID pos over COVID neg patients in the days preceding confirmed diagnostic testing. Rhinitis is also a potential early signal of COVID pos patients that requires some consideration (2.2-fold amplification, p-value = 2.25E-29). keywords: covid; covid pos; covid-19; day; neg; patients; pcr; pcr testing; pos; symptoms; testing cache: cord-348975-plne3xlz.txt plain text: cord-348975-plne3xlz.txt item: #2700 of 2876 id: cord-349031-tbof9yqi author: Chen, Shiu-Jau title: Novel Antiviral Strategies in the Treatment of COVID-19: A Review date: 2020-08-20 words: 5473 flesch: 38 summary: Nord experience Clinical trials on drug repositioning for COVID-19 treatment COVID-19 pandemic: An overview of epidemiology, parthenogenesis, diagnostics and potential vaccines and therapeutics Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial Inhibition of cytokine signaling by ruxolitinib and implications for COVID-19 treatment Convalescent plasma in Covid-19: Possible mechanisms of action Treatment of 5 critically Ill patients with COVID-19 with convalescent plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19 Treatment with convalescent plasma for COVID-19 patients in Wuhan Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory distress syndrome in Korea Deployment of convalescent plasma for the prevention and treatment of COVID-19 Convalescent plasma transfusion for the treatment of COVID-19: Systematic review Potential application of the CRISPR/Cas9 system against herpesvirus infections Gene editing technologies and Applications Opioid addiction, genetic susceptibility and medical treatments: A Review Development of CRISPR as an antiviral strategy to combat SARS-CoV-2 and influenza Mesenchymal stem cell therapy for COVID-19: Present or future Current status of cell-based therapies for respiratory virus infections: Applicability to COVID-19 Transplantation of ACE2-Mesenchymal stem cells improve the outcome of patients with COVID-19 pneumonia Expanded umbilical cord mesenchymal stem cells (UC-MSCs) as a therapeutic strategy in managing critically Ill COVID-19 patients: The case for compassionate use Convalescent plasma therapy for persistent hepatitis E virus infection Convalescent plasma new evidence for an old therapeutic tool Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia Use of convalescent plasma in Ebola virus infection Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Use of convalescent plasma therapy in SARS patients in Hong Kong Convalescent plasma as a potential therapy for COVID-19 Collecting and evaluating convalescent plasma for COVID-19 treatment: In this review, we explore the applications, possible mechanisms, and efficacy in successful cases using convalescent plasma, CRISPR, and MSC therapy for COVID-19 treatment, respectively. keywords: cells; convalescent; convalescent plasma; covid-19; disease; efficacy; patients; plasma; sars; therapy; treatment; use cache: cord-349031-tbof9yqi.txt plain text: cord-349031-tbof9yqi.txt item: #2701 of 2876 id: cord-349076-x3rjasg0 author: Jarczak, Dominik title: Use of Intravenous Immunoglobulins in Sepsis Therapy—A Clinical View date: 2020-08-03 words: 7030 flesch: 30 summary: Impact of neutrophil and organism age on neutrophil extracellular trap formation Neutrophil extracellular traps in sepsis A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma Myeloid-derived suppressor cells coming of age Intravenous immunoglobulins-understanding properties and mechanisms Innate response activator B cells: Origins and functions Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis An extended leukocyte differential count (16 types of circulating leukocytes) using the cytodiff flow cytometric system can provide informations for the discrimination of sepsis severity and prediction of outcome in sepsis patients Early alterations of B cells in patients with septic shock Alterations of B Cells in Immunosuppressive Phase of Septic Shock Patients Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis-A meta-analysis Early levels in blood of immunoglobulin M and natural killer cells predict outcome in nonseptic critically ill patients Bench-to-bedside review: Immunoglobulin therapy for sepsis-biological plausibility from a critical care perspective Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis? Nevertheless, the Surviving Sepsis Campaign (SSC) guidelines suggested against IVIg use in sepsis therapy 2016 due to lack of sufficient evidence of efficacy for preparations containing only IgG keywords: activation; anti; cells; igg; igm; immunoglobulins; intravenous; ivig; patients; response; sepsis; shock; therapy; use cache: cord-349076-x3rjasg0.txt plain text: cord-349076-x3rjasg0.txt item: #2702 of 2876 id: cord-349144-cvmebr3f author: Barca, Ida title: Telemedicine in Oral and Maxillo-Facial Surgery: An Effective Alternative in Post COVID-19 Pandemic date: 2020-10-09 words: 4864 flesch: 34 summary: The experience acquired by the authors during the COVID-19 pandemic suggests that telemedicine is indicated above all in the follow-up of cancer patients, because they are immunosuppressed for previous chemo/radiation treatments and therefore subject to greater risk of contagion, in chronic as well as urgent visits for suspected malignancy and in patients who live far from a hospital. From the experience acquired by the authors during the COVID-19 pandemic, it emerged that TM is indicated above all in the follow-up of cancer patients, because they are immunosuppressed for previous chemo/radiation treatments and therefore subject to greater risk of contagion, and chronic as well as urgent visits for suspected malignancy [10] . keywords: consultation; covid-19; group; health; pandemic; patients; photos; surgery; telemedicine cache: cord-349144-cvmebr3f.txt plain text: cord-349144-cvmebr3f.txt item: #2703 of 2876 id: cord-349210-8t4a5qqo author: Ji, Ping title: Immunomodulatory Therapeutic Proteins in COVID‐19: Current Clinical Development and Clinical Pharmacology Considerations date: 2020-08-10 words: 7716 flesch: 34 summary: About 5-10% of COVID-19 patients developed lung injury and respiratory distress that progressed to acute respiratory distress syndrome (ARDS). A minority of COVID-19 patients will transition into the severe and critical stages of the illness, which manifest as an extrapulmonary systemic hyperinflammation syndrome. keywords: clinical; cov-2; covid-19; disease; dose; dosing; infection; patients; pneumonia; proteins; risk; sars; treatment; trial cache: cord-349210-8t4a5qqo.txt plain text: cord-349210-8t4a5qqo.txt item: #2704 of 2876 id: cord-349263-mmfrqyrc author: Rodríguez, A. title: Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic date: 2020-11-09 words: 4184 flesch: 52 summary: Patients Patients admitted due to COVID-19 and respiratory failure. key: cord-349263-mmfrqyrc authors: Rodríguez, A.; Moreno, G.; Gómez, J.; Carbonell, R.; Picó-Plana, E.; Benavent Bofill, C.; Sánchez Parrilla, R.; Trefler, S.; Esteve Pitarch, E.; Canadell, L.; Teixido, X.; Claverias, L.; Bodí, M. title: Severe infection due to the SARS-CoV-2 coronavirus: Experience of a tertiary hospital with COVID-19 patients during the 2020 pandemic date: 2020-11-09 journal: nan DOI: 10.1016/j.medine.2020.05.005 sha: doc_id: 349263 cord_uid: mmfrqyrc Objective To describe the clinical and respiratory characteristics of a cohort of 43 patients with COVID-19 after an evolutive period of 28 days. keywords: admission; covid-19; days; icu; imv; mortality; patients; rate; study cache: cord-349263-mmfrqyrc.txt plain text: cord-349263-mmfrqyrc.txt item: #2705 of 2876 id: cord-349280-12hc3mhq author: Drake, Justin A. title: Analysis of the Survival Impact of Postoperative Chemotherapy After Preoperative Chemotherapy and Resection for Gastric Cancer date: 2020-08-27 words: 3751 flesch: 28 summary: Management of locally advanced gastroesophageal cancer: still a multidisciplinary global challenge? Comparative effectiveness of preoperative, postoperative, and perioperative treatments for resectable gastric cancer: a network meta-analysis of the literature from the past 20 years Gastric Cancer (version 1 Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial Perioperative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, openlabel, randomised phase 2-3 trial Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial The National Cancer Data Base: a powerful initiative to improve cancer care in the United States Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial Impact of postoperative chemotherapy in patients with locally advanced gastroesophageal adenocarcinoma treated with perioperative chemotherapy strategy Perioperative platin-based chemotherapy for locally advanced esophagogastric adenocarcinoma: postoperative chemotherapy has a substantial impact on outcome Poor compliance with perioperative chemotherapy for resectable gastric cancer and its impact on survival The postoperative part of perioperative chemotherapy fails to provide a survival benefit in completely resected esophagogastric adenocarcinoma Demographic disparities in patterns of care and survival outcomes for patients with resected gastric adenocarcinoma Variations in gastric cancer care: a trend beyond racial disparities Racial disparities in preoperative chemotherapy use in gastric cancer patients in the United States: analysis of the National Cancer Data Base Morbidity and mortality associated with gastrectomy for gastric cancer Interaction of postoperative morbidity and receipt of adjuvant therapy on long-term survival after resection for gastric adenocarcinoma: results from the U.S. Gastric Cancer Collaborative Poor survival rate in patients with postoperative intra-abdominal infectious complications following curative gastrectomy for gastric cancer Given the observed low rates for initiation and completion of postoperative chemotherapy, its true effect on survival remains unclear. keywords: analysis; cancer; chemotherapy; gastric; patients; perioperative; resection; survival cache: cord-349280-12hc3mhq.txt plain text: cord-349280-12hc3mhq.txt item: #2706 of 2876 id: cord-349329-f0pbd968 author: Bosteels, Cedric title: Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial date: 2020-06-05 words: 12419 flesch: 40 summary: The study will be conducted cfr the latest version of the ICH E6 (R2) GCP guidelines, creating a standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical studies that provides assurance that the data and reported results are accurate and that the rights, integrity and confidentiality of study subjects are protected. Monitoring services will consist of the following (non-exhaustive list): -review of informed consents and the followed process -check on recruitment status -checking for protocol deviations/violations -checking GCP compatibility -check on safety reporting compliance -IMP handling and storage -review of study data … This study can be inspected at any time by regulatory agencies during or after completion of the study. keywords: acute; ards; blood; covid-19; csf; data; day; days; failure; group; intervention; leukine; lung; patients; period; sargramostim; study; subject; treatment cache: cord-349329-f0pbd968.txt plain text: cord-349329-f0pbd968.txt item: #2707 of 2876 id: cord-349360-dv4lxx52 author: Cozza, Valerio title: I-ACTSS-COVID-19—the Italian acute care and trauma surgery survey for COVID-19 pandemic outbreak date: 2020-06-24 words: 3436 flesch: 44 summary: Likely, the caseload was a crucial factor, together with resources availability, for choosing to admit suspected and confirmed COVID-19 patients to specific surgical wards or in mixed medical and surgical COVID + wards. This survey shows a strong interest on the part of acute care surgeons, involved as first line operators in managing the pathways of suspected and confirmed patients and often directly treating COVID-19 patients. keywords: care; covid-19; emergency; patients; surgery; trauma cache: cord-349360-dv4lxx52.txt plain text: cord-349360-dv4lxx52.txt item: #2708 of 2876 id: cord-349396-a6zyioc1 author: Tsurumi, Amy title: Multi-biomarker Prediction Models for Multiple Infection Episodes Following Blunt Trauma date: 2020-10-07 words: 4602 flesch: 25 summary: CD96 Emerges as Modulator of Immune Responses Increases in mortality, length of stay, and cost associated with hospital-acquired infections in trauma patients The Intestinal Microbiome in Infectious Diseases: The Clinical Relevance of a Rapidly Emerging Field Predictors of mortality in geriatric trauma patients: a systematic review and meta-analysis Failure to normalize lymphopenia following trauma is associated with increased mortality Deaths: Leading Causes for 2016 Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources Innate immune responses to trauma Hepatocyte growth factor in physiology and infectious diseases Sterile post-traumatic immunosuppression Trauma severity scoring systems as predictors of nosocomial infection arrayQualityMetrics--a bioconductor package for quality assessment of microarray data APACHE II: a severity of disease classification system Causal analysis approaches in Ingenuity Pathway Analysis The global burden of injuries Building Predictive Models in R Using the caret Package Why significant variables aren't automatically good predictors Immunonutrition -the influence of early postoperative glutamine supplementation in enteral/parenteral nutrition on immune response, wound healing and length of hospital stay in multiple trauma patients and patients after extensive surgery Why have clinical trials in sepsis failed? Crisis Standards of Care Planning Guidance for the COVID-19 Pandemic (Department of Public Health, Executive Office of Health and Human Services) Crisis Standards of Care: A Toolkit for Indicators and Triggers A Model Hospital Policy for Allocating Scarce Critical Care Resources Drug for severe sepsis is withdrawn from market, fails to reduce mortality Simplified estimates of the probability of death after burn injuries: extending and updating the baux score Leukocytosis as prognostic indicator of major injury Integrating Predictive Analytics Into High-Value Care: The Dawn of Precision Delivery Potential Expanded Indications for Neprilysin Inhibitors limma powers differential expression analyses for RNA-sequencing and microarray studies pROC: an open-source package for R and S+ to analyze and compare ROC curves EMA -A R package for Easy Microarray data analysis epiR: Tools for the Analysis of Epidemiological Data A comprehensive time-coursebased multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set Risk Stratification and Prognosis in Sepsis: What Have We Learned from Microarrays? Infection control in the multidrug-resistant era: tending the human microbiome Immunosuppression after trauma The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites gcrma: Among trauma patients, infections and infections-related complications contribute to substantial mortality and morbidity, and prolonged hospital stay, significantly adding to health care costs (Cole et al., 2014; Dutton et al., 2010; Glance et al., 2011; Hashmi et al., 2014) . keywords: cases; immune; infections; miie; patients; response; study; trauma cache: cord-349396-a6zyioc1.txt plain text: cord-349396-a6zyioc1.txt item: #2709 of 2876 id: cord-349408-2ser9zjc author: Iannuzzi, Nicholas P. title: An Orthopaedic Department’s Response to the COVID-19 Health-Care Crisis: Indirect and Direct Actions with Thoughts for the Future date: 2020-05-05 words: 2257 flesch: 36 summary: We consider direct actions to be those taken in addition to our normal practice-actions involving direct patient care but performed outside of the usual setting. COVID-19 guidelines for triage of orthopaedic patients COVID-19-new insights on a rapidly changing epidemic Care for critically ill patients with COVID-19 Trump wants to 'reopen America Coronavirus math shows the importance of social distancing, and the horrible consequences of not doing it Effects of the length of stay on the cost of total knee and total hip arthroplasty from 2002 to 2013 Inpatient consults and complications during primary total joint arthroplasty in a bundled care model Managing resident workforce and education during the COVID-19 pandemic keywords: care; covid-19; health; orthopaedic; patients cache: cord-349408-2ser9zjc.txt plain text: cord-349408-2ser9zjc.txt item: #2710 of 2876 id: cord-349439-3z0b77r5 author: Mandal, Amitabha title: A Systematic Review on Tracheostomy in COVID-19 Patients: Current Guidelines and Safety Measures date: 2020-09-28 words: 2497 flesch: 47 summary: In this review various international guidelines and sources were put together, and we aim to summarize in a systematic way the available recommendations: indications, timing, technique and safety measures for tracheostomy for COVID-19 patients, from all over the world. However there are no current guidelines regarding the optimal time of tracheostomy in COVID-19 patients but most of the European countries following local policy of 14 days before performing tracheostomy. keywords: care; coronavirus; covid-19; pandemic; patients; procedure; tracheostomy cache: cord-349439-3z0b77r5.txt plain text: cord-349439-3z0b77r5.txt item: #2711 of 2876 id: cord-349500-603v8lfb author: Neurath, Markus F title: Covid-19 and immunomodulation in IBD date: 2020-04-16 words: 6564 flesch: 37 summary: In contrast, another study reported that covid-19 ICU patients had significantly higher serum levels of TNF than non-ICU patients. Therefore, this review will address the following questions: ► What is the evidence for intestinal covid-19 disease and how does covid-19 induce mucosal immune cell activation and a cytokine release syndrome? keywords: ace2; cell; clinical; coronavirus; cov-2; covid-19; cytokine; disease; ibd; patients; sars; syndrome; therapy cache: cord-349500-603v8lfb.txt plain text: cord-349500-603v8lfb.txt item: #2712 of 2876 id: cord-349533-51cex2sl author: Yeoh, Su-Ann title: Are treat-to-target and dose tapering strategies for rheumatoid arthritis possible during the COVID-19 pandemic? date: 2020-06-08 words: 1598 flesch: 32 summary: Treat-to-target has been a cornerstone in the management of rheumatoid arthritis over the past decade and has the ultimate aim of achieving disease remission. Centre for Rheumatology, Division of Medicine, University College London, London WC1E 6JF, UK Treating rheumatoid arthritis to target: recommendations of an international task force A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry Is treat-to-target really working in rheumatoid arthritis? keywords: arthritis; disease; patients; target; treat cache: cord-349533-51cex2sl.txt plain text: cord-349533-51cex2sl.txt item: #2713 of 2876 id: cord-349561-4mkiwg9k author: Porta, Alessandra Della title: Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians date: 2020-07-19 words: 9237 flesch: 37 summary: Many of the features of aminoquinoline toxicity are pertinent to ED care, particularly serum abnormalities and cardiac, respiratory, and neurologic phenomena. As opposed to quinine, aminoquinoline toxicity is less commonly associated with acute onset of GI symptoms such as nausea, vomiting, and diarrhea. keywords: aminoquinoline; chloroquine; hydroxychloroquine; overdose; patients; potassium; r n; sodium; toxicity; treatment; use cache: cord-349561-4mkiwg9k.txt plain text: cord-349561-4mkiwg9k.txt item: #2714 of 2876 id: cord-349565-g1emvmdu author: Conti, Clara Benedetta title: Bleeding in COVID-19 severe pneumonia: The other side of abnormal coagulation pattern? date: 2020-05-07 words: 1329 flesch: 41 summary: In the available studies, COVID-19 patients showed alterations of coagulation test, with significant increase of D-Dimer levels associated with severity of illness and adverse outcomes (2). If on one hand the protrombotic features have been underlined and few reports about minor or obscure/occult GI bleeding appeared in literature, up to now no major internal bleeding have been observed in COVID-19 patients. keywords: artery; bleeding; covid-19; patients cache: cord-349565-g1emvmdu.txt plain text: cord-349565-g1emvmdu.txt item: #2715 of 2876 id: cord-349566-zx9kt144 author: de Alencar, Julio Cesar Garcia title: Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19 date: 2020-09-23 words: 2959 flesch: 48 summary: We hypothesized that N-acetylcysteine (NAC) administration could restore this redox homeostasis and suppress unfavorable evolution in Covid-19 patients. It is necessary, therefore, to discuss the causes of this treatment failure in improving respiratory function in Covid-19 patients. keywords: angii; angiotensin; covid-19; nac; patients; placebo; redox cache: cord-349566-zx9kt144.txt plain text: cord-349566-zx9kt144.txt item: #2716 of 2876 id: cord-349678-79zlgjqi author: Warrior, Krishnan title: Acute Limb Ischemia Due to Arterial Thrombosis Associated With Coronavirus Disease 2019 date: 2020-06-11 words: 2535 flesch: 43 summary: A recently published cohort study from Lombardy, Italy, demonstrated a higher-than-expected incidence of ALI due to arterial thrombosis in COVID-19 pneumonia patients (12) . The most common etiology of ALI is cardiac embolization, particularly in patients without preexisting peripheral arterial disease (13) . keywords: arterial; artery; covid-19; dimer; disease; patients; thrombosis cache: cord-349678-79zlgjqi.txt plain text: cord-349678-79zlgjqi.txt item: #2717 of 2876 id: cord-349740-xed4aybr author: Wang, Yulong title: Recommendations of protective measures for orthopedic surgeons during COVID-19 pandemic date: 2020-06-10 words: 4271 flesch: 45 summary: After screening for COVID-19 (Table 3) , COVID-19 negative patients can be transferred to the general ward in a single room, minimizing the number of family caregivers (at most 1 member) and forbidding other family members to visit [30, 39] . Lessons learnt from our experience provide some recommendations of protective measures during the entire diagnosis and treatment process of traumatic patients and help others to manage orthopedic patients with COVID-19, to reduce the risk of cross-infection between patients and to protect healthcare workers during work. keywords: covid-19; emergency; infection; measures; orthopedic; pandemic; patients; room; surgery; treatment cache: cord-349740-xed4aybr.txt plain text: cord-349740-xed4aybr.txt item: #2718 of 2876 id: cord-349775-zwslhjju author: Brittain-Long, Robin title: Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: a randomised, controlled trial date: 2011-04-26 words: 4616 flesch: 39 summary: A recent retrospective study of primary care patients in a comparable Swedish region recorded an antibiotic prescription rate of 45% for all patients with ARTIs, 60% for patients with acute bronchitis and 16% for patients with the 'common cold' [13] . We conducted an investigator-initiated, multicentre, prospective, randomised, controlled trial with adult patients in a primary care setting. keywords: antibiotic; group; patients; pcr; prescription; result; study; use; visit cache: cord-349775-zwslhjju.txt plain text: cord-349775-zwslhjju.txt item: #2719 of 2876 id: cord-349838-p6vfzbla author: Algwaiz, Ghada title: Real-world issues and potential solutions in HCT during the COVID-19 pandemic: Perspectives from the WBMT and the CIBMTR's Health Services and International Studies Committee date: 2020-07-24 words: 4064 flesch: 34 summary: Exposure (especially to contacts with COVID-19 patients) and symptom history, physical examination, and chest imaging are helpful to evaluate HCT patients. Realizing the challenges as a result of this pandemic affecting the daily practice of the HCT centers, and the recognition of the variability in practice worldwide, the Worldwide Network for Blood & Marrow Transplantation (WBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR) Health Services and International Studies Committee have jointly produced an expert opinion statement as a general guide to deal with certain aspects of HCT including diagnostics for SARS-CoV-2 in HCT patients, pre-and-post-HCT management, donor issues, medical tourism and facilities management. keywords: blood; cell; covid-19; hct; infection; patients; pcr; risk; sars; therapy; transplantation; treatment cache: cord-349838-p6vfzbla.txt plain text: cord-349838-p6vfzbla.txt item: #2720 of 2876 id: cord-349949-jp0hvcg6 author: Freer, Phoebe E. title: The impact of the COVID-19 pandemic on Breast Imaging date: 2020-09-22 words: 5757 flesch: 39 summary: In addition to having work and economic worries, some radiologists and staff were redeployed in the early days in hotspots to better serve COVID-19 patient care. Some centers, such as Magee-Breast Cancer Program and Johns Hopkins published multi-disciplinary algorithms of how best to triage breast cancer patients, broken down by sub-types program 21, 22 . keywords: breast; cancer; care; coronavirus; covid-19; disease; health; imaging; pandemic; patients; radiology; study cache: cord-349949-jp0hvcg6.txt plain text: cord-349949-jp0hvcg6.txt item: #2721 of 2876 id: cord-349958-126yb5se author: Raskin, Jo title: CANCER IN THE TIME OF COVID: Expert opinion on how to adapt current practice date: 2020-04-16 words: 1591 flesch: 45 summary: 349958 cord_uid: 126yb5se The susceptibility of cancer patients to adverse outcome of viral infections is well known from past experiences, e.g. Influenza increasing the risk of hospital admission with respiratory distress four times, and the risk of death ten times, compared to patients without cancer [1]. To the editor: The susceptibility of cancer patients to adverse outcome of viral infections is well known from past experiences, e.g. Influenza increasing the risk of hospital admission with respiratory distress four times, and the risk of death ten times, compared to patients without cancer [1] . keywords: cancer; chemotherapy; hospital; patients cache: cord-349958-126yb5se.txt plain text: cord-349958-126yb5se.txt item: #2722 of 2876 id: cord-350052-9431xqu1 author: Kim, Ji Heui title: Detection of respiratory viruses in adult patients with perennial allergic rhinitis date: 2013-09-14 words: 3063 flesch: 44 summary: To evaluate whether patients with allergic rhinitis have an increased frequency of respiratory virus detection in a prospective case–control study. Respiratory virus detection was facilitated by multiplex PCR. keywords: control; detection; nasal; par; patients; viruses cache: cord-350052-9431xqu1.txt plain text: cord-350052-9431xqu1.txt item: #2723 of 2876 id: cord-350065-frg7gvf5 author: Parolari, Alessandro title: Safety for all: coronavirus disease 2019 pandemic and cardiac surgery: a roadmap to ‘phase’ 2 date: 2020-05-11 words: 2444 flesch: 41 summary: Although some areas have used the 'hub and spoke' approach whereby hospitals delivering cardiac surgery are not routinely treating COVID-19 patients, the focus and the challenge during phase 2 are the reconversion of the cardiac surgical departments where resources had previously been redeployed for the treatment of infected patients, the most common approach adopted in Italy during phase 1. Given that these institutions will continue to care for COVID-19 patients, we recommend that clearly separated pathways in COVID-19dedicated and COVID-19-free areas are developed within the hospital. keywords: areas; cardiac; care; covid-19; patients; risk cache: cord-350065-frg7gvf5.txt plain text: cord-350065-frg7gvf5.txt item: #2724 of 2876 id: cord-350131-rsrlri8m author: Amer, Mohamed A. title: Early recovery patterns of olfactory disorders in COVID-19 patients; a clinical cohort study date: 2020-09-14 words: 2168 flesch: 38 summary: On the other hand, some centers adopt using short course of oral steroid in patients with a persistent loss of smell related to COVID-19 and in those patients with persistent loss of sense of smell following covid-19 after at least two weeks since diagnosis, they believe that this protocol seems to give better outcomes than observation (22) To our knowledge, this is the 1 st Egyptian article discussing otorhinolaryngological manifestations of COVID-19 patients with detailed analysis of olfactory dysfunction and their pattern of recovery during COVID-19 pandemic, however, the present study Clinical Characteristics of Coronavirus Disease 2019 in China WHO coronavirus disease (COVID-19) dashboard, WHO, viewed 03 Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore Early recovery following new onset anosmia during the COVID-19 pandemic -an observational cohort study Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study The diagnosis of a conductive olfactory loss Pivotal Role of Receptor-Interacting Protein Kinase 1 and Mixed Lineage Kinase Domain-Like in Neuronal Cell Death Induced by the Human Neuroinvasive Coronavirus OC43 Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients Development and validity of the DyNaChron questionnaire for chronic nasal dysfunction Possible link between anosmia and COVID-19: sniffing out the truth Association of chemosensory dysfunction and Covid-19 in patients presenting with influenza-like symptoms Incomplete and late recovery of sudden olfactory dysfunction in COVID-19 Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study Early recovery following new onset anosmia during the COVID-19 pandemic an observational cohort study Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) infection is likely to be androgen mediated Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis COVID-19 infection and glucocorticoids: update from the Italian Society of Endocrinology Expert Opinion on steroid replacement in adrenal insufficiency Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: an ARIA-EAACI statement Anosmia and loss of smell in the era of covid-19 The mean age of patients was 34.26±11.91 years 56 females(56.3%) and 40 males with evident female predominance, this goes in accordance with Kosugi et al (13) who studied 183 olfactory patients of COVID-19 with mean age of 36 years and female predominance 53.1% of their patients , similarly, in a multicentric study of COVID-19 patients performed by Lechien et al. keywords: covid-19; olfactory; patients; recovery; study cache: cord-350131-rsrlri8m.txt plain text: cord-350131-rsrlri8m.txt item: #2725 of 2876 id: cord-350166-loxe11d6 author: Garmendia, Onintza title: Low-cost, easy-to-build non-invasive pressure support ventilator for under-resourced regions: open source hardware description, performance and feasibility testing date: 2020-04-20 words: 4275 flesch: 28 summary: Although tidal volume was not a direct outcome variable controlled by pressure support ventilators, it is interesting to note that the prototype ventilator resulted in tidal volumes that were similar to the ones generated by the commercial device ( Figure 5.B) , adding further support to the suitability of the prototype ventilator for generating inspiratory pressure waveforms and adequate tidal volumes in a wide spectrum of simulated patients ( Table 1 ). In this context, alternative solutions that are based on in-house manufacturing of pressure support devices (7, 8) could reduce the serious shortage of ventilators in LMICs. keywords: bench; breathing; device; figure; medical; patient; pressure; prototype; test; ventilator cache: cord-350166-loxe11d6.txt plain text: cord-350166-loxe11d6.txt item: #2726 of 2876 id: cord-350179-ltk5hfc4 author: Paganini, Matteo title: Translating COVID-19 Pandemic Surge Theory to Practice in the Emergency Department: How to Expand Structure date: 2020-03-27 words: 4427 flesch: 44 summary: This study reviewed the available surge science literature specifically to guide an emergency department’s surge structural response using a translational science approach to answer the question: How does the concept of sudden onset mass casualty incident surge capability apply to the process to expand COVID-19 pandemic surge structure response? How does the concept of sudden onset mass casualty incident (MCI) surge capability apply to the process to expand COVID-19 pandemic surge structure response? keywords: care; covid-19; health; mci; patients; response; space; staff; structure; surge; team cache: cord-350179-ltk5hfc4.txt plain text: cord-350179-ltk5hfc4.txt item: #2727 of 2876 id: cord-350200-1w5u3w8i author: Hendren, Elizabeth M. title: An Interprofessional Approach in Caring for a Patient on Maintenance Hemodialysis with COVID-19 in Toronto, Canada: An Educational Case Report date: 2020-09-08 words: 3333 flesch: 44 summary: Finally, dialysis patients were informed of each change in the screening protocol with a printed letter provided in the HD unit, along with updated signs posted at the entrance of the dialysis unit. Our early experiences may provide insight into the importance of maintaining an interprofessional approach in caring for HD patients with COVID-19. keywords: care; covid-19; dialysis; hospital; infection; patient; screening cache: cord-350200-1w5u3w8i.txt plain text: cord-350200-1w5u3w8i.txt item: #2728 of 2876 id: cord-350232-zml4o93t author: Peck, Richard W title: A Real‐World Evidence Framework for Optimising Dosing in All Patients with COVID‐19 date: 2020-05-23 words: 1932 flesch: 37 summary: Pharmacologic treatments for coronavirus Disease 2019 (COVID-19) Challenges in drug deve;opment posed by the COVID-19 pandemic: An opportunity for clinical pharmacology Drug dosing recommendations for all patients: A roadmap for change Optimizing hydroxychloroquine dosing for patients with COVID-19: An integrative modelling approach for effective drug repurposing Groups at high risk of severe illness CYP-mediated therapeutic protein-drug interactions Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load The gendered dimensions of COVID-19 NIH to launch public-private partnership to speed COVID-19 vaccine and treatment options A model-and real world data-based framework for continuous updating of dosing recommendations and labelling of treatments for COVID-19 patients (hsCRP: high sensitivity C-reactive protein, Rx: treatment, PKPD: pharmacokinetic/pharmacodynamics, VK: viral kinetic. Several drugs are being repurposed into clinical trials in COVID-19 patients, ranging from drugs already well established in other diseases, such as chloroquine/hydroxychloroquine, lopinavir+ ritonavir, azithromycin and tocilizumab/sarilumab, to those such as remdesivir still in development for their initial indication (1) . keywords: covid-19; data; disease; drug; patients cache: cord-350232-zml4o93t.txt plain text: cord-350232-zml4o93t.txt item: #2729 of 2876 id: cord-350325-vu8v9epr author: Malih, Narges title: Unexpected Presentation of COVID-19 in a 38-Year-Old Male Patient: A Case Report date: 2020-07-29 words: 1695 flesch: 56 summary: Data A special gratitude we give to Vice-Chancellor for Health Affairs of Shahid Beheshti University of Medical Sciences, whose contribution in stimulating suggestions and encouragement, helped us to join to primary health care clinic of Shahid Beheshti University of Medical Sciences, which is specialized for COVID-19 epidemic and made us have unique experiences on COVID-19 disease. The cutaneous manifestations of COVID-19 cases in Recalcati keywords: case; covid-19; patients; rash; symptoms cache: cord-350325-vu8v9epr.txt plain text: cord-350325-vu8v9epr.txt item: #2730 of 2876 id: cord-350338-lcsa06gm author: Wang, Kun title: Clinical and laboratory predictors of in-hospital mortality in patients with COVID-19: a cohort study in Wuhan, China date: 2020-05-03 words: 2475 flesch: 45 summary: The MuLBSTA Score Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding From gene to proteinexperimental and clinical studies of ACE2 in blood pressure control and arterial hypertension Preparing for the next influenza pandemic An interferon-γ-related cytokine storm in SARS patients Corticosteroid Treatment Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A (H1N1) Virus in Mice The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration Understanding the T cell immune response in SARS coronavirus infection Biochemical Aspects of Coronavirus Replication and Virus-Host Interaction Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Specific ACE2 Expression in Cholangiocytes Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical features of patients infected with 2019 novel coronavirus in Wuhan Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care Boosted tree model reforms multimodal magnetic resonance imaging infarct prediction in acute stroke Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach Innate immune responses in the ageing lung Clinical Features Predicting Mortality Risk in Patients With Viral Pneumonia: keywords: clinical; cohort; covid-19; hospital; model; patients; study cache: cord-350338-lcsa06gm.txt plain text: cord-350338-lcsa06gm.txt item: #2731 of 2876 id: cord-350401-suefuurq author: Lima-Setta, Fernanda title: Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study()()() date: 2020-11-09 words: 3946 flesch: 41 summary: Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection Pediatric critical care and COVID-19 Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome Multisystem inflammatory syndrome associated with coronavirus disease in children: a multi-centered study in Belém Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis Epidemiological and clinical features of Kawasaki disease in Spain over 5 years and risk factors for aneurysm development Considering how biological sex impacts immune responses and COVID-19 outcomes COVID-19: consider cytokine storm syndromes and immunosuppression Human leukocyte antigen susceptibility map for severe acute respiratory syndrome coronavirus 2 Genomic diversity of severe acute respiratory syndrome-coronavirus 2 in patients with coronavirus disease 2019 Use of biomarkers in pediatric sepsis: literature review COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome? [23] IL-6 appears to play an important role in severe adult patients with COVID-19, in whom the compassionate use of tocilizumab for pharmacologic inhibition of IL-6 has been described. keywords: children; covid-19; mis; patients; sars; study; syndrome cache: cord-350401-suefuurq.txt plain text: cord-350401-suefuurq.txt item: #2732 of 2876 id: cord-350408-rqlkwoya author: Rajewsky, Nikolaus title: LifeTime and improving European healthcare through cell-based interceptive medicine date: 2020-09-07 words: 8068 flesch: 24 summary: The stratification of patients on the basis of underlying disease mechanisms, assessed in situ within single cells, will help physicians to select the most appropriate treatment(s) or to use combination therapies that are tailored to the individual. A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation A unique microglia type associated with restricting development of Alzheimer's disease Single-cell transcriptomic analysis of Alzheimer's disease Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function An immune-cell signature of bacterial sepsis Multi-omics profiling of mouse gastrulation at single-cell resolution scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells Simultaneous quantification of protein-DNA contacts and transcriptomes in single cells Spatial transcriptomics and in situ sequencing to study Alzheimer's disease Dissecting cellular crosstalk by sequencing physically interacting cells Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region Gene expression cartography Visualization and analysis of gene expression in tissue sections by spatial transcriptomics Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids High-definition spatial transcriptomics for in situ tissue profiling Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells Microscopy-based chromosome conformation capture enables simultaneous visualization of genome organization and transcription in intact organisms RNA imaging. keywords: approaches; cancer; cell; data; development; disease; european; fig; human; information; lifetime; medicine; models; molecular; multi; patient; research; technologies cache: cord-350408-rqlkwoya.txt plain text: cord-350408-rqlkwoya.txt item: #2733 of 2876 id: cord-350437-dq1il88y author: Reale, Maria Lucia title: SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit date: 2020-08-19 words: 4183 flesch: 42 summary: This retrospective study aims to collect epidemiological, clinical, laboratory, and therapeutic data from SARS-CoV-2 positive cancer patients hospitalized at the Onco-Covid unit in San Luigi Gonzaga Hospital, Italy, one of the few oncological wards for cancer patients with SARS-Cov-2 infection, in order to provide a deeper insight into the clinical evolution of infection in cancer patients, particularly in lung cancer patients. Cancer patients are one of the potentially most vulnerable cohorts of people, but data about their management are still few. keywords: cancer; covid-19; data; days; diagnosis; infection; patients; sars; treatment cache: cord-350437-dq1il88y.txt plain text: cord-350437-dq1il88y.txt item: #2734 of 2876 id: cord-350529-yqtu059x author: Evans, Samantha title: Implementation of a clinical pathway for the surgical treatment of colorectal cancer during the COVID‐19 pandemic date: 2020-07-12 words: 1930 flesch: 45 summary: St Mark's Hospital in London, UK addressed these challenges at an early stage, as their campus was identified as one of the capital's main referral centres for COVID-19 patients. The operating rooms and wards of St Mark's Hospital at the London North West University Hospitals NHS Trust were not operational due to a surge of COVID-19 patients from the 25 th March to the 9 th April 2020. keywords: cancer; covid-19; pandemic; patients; surgery cache: cord-350529-yqtu059x.txt plain text: cord-350529-yqtu059x.txt item: #2735 of 2876 id: cord-350571-6tapkjb6 author: None title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 words: 106086 flesch: 45 summary: Clinical pharmacists have a role to evaluate and optimize the appropriateness and effectiveness of patient's medications. DTSIs interventions (treatment group) consist in: motivational interview, sharing and delivery of printed, explanatory material in the patient's native language, reconciliation of patients medications at hospital admission and at discharge; identification of potential risks due to drug-drug interactions; monitoring of compliance to drug therapy, and finally detection of adverse drug reactions (ADRs) occurring in the course of care. keywords: abstract; adherence; administration; admission; age; aim; analysis; antibiotics; assessment; associated; average; background; cancer; care; cases; clinical; community; conclusion; control; criteria; data; day; days; department; design; discharge; discrepancies; disease; dispensing; dosage; dose; drug; effects; following; general; group; guidelines; health; home; hospital; hospital pharmacy; impact; increase; information; interactions; interventions; knowledge; level; main; management; mean; measures; median; medical; medication; medication adherence; medication reconciliation; medicines; method; monitoring; months; n =; non; number; nurses; objective; oral; order; outcome; outcome measures; patients; period; pharmaceutical; pharmacists; pharmacy; physicians; potential; practice; prescribed; prescription; problems; process; projects; quality; research; results; review; risk; risk patients; role; safety; score; service; setting; study; survey; team; therapy; time; total; treatment; type; university; use; years cache: cord-350571-6tapkjb6.txt plain text: cord-350571-6tapkjb6.txt item: #2736 of 2876 id: cord-350578-wyz5jyjh author: Bai, Li title: Chinese experts’ consensus on the Internet of Things-aided diagnosis and treatment of coronavirus disease 2019 (COVID-19) date: 2020-12-31 words: 5459 flesch: 38 summary: To avoid misdiagnosis, suspected patients should be isolated and monitored for 14 days. nCapp intelligent assisted treatment and management for patients suspected of COVID-19 nCapp automatically generates prompt diagnosis according to the national guidelines, and patients who meet the criteria are suggested to be reported or transferred to the designated hospitals. keywords: cloud; coronavirus; covid-19; data; diagnosis; ncapp; online; patients; pneumonia; technology; treatment cache: cord-350578-wyz5jyjh.txt plain text: cord-350578-wyz5jyjh.txt item: #2737 of 2876 id: cord-350589-h6hotlqk author: Cieszanowski, Andrzej title: Management of patients with COVID-19 in radiology departments, and indications regarding imaging studies – recommendations of the Polish Medical Society of Radiology date: 2020-04-29 words: 3429 flesch: 52 summary: Imaging studies in COVID-19 patients are best performed in less-attended areas of RDs, to avoid unnecessary exposure of personnel and other patients [8] . • • Where numbers of scanners in an RD are sufficient, machines for COVID-19 patients and for others are designated as separate [7] . keywords: chest; covid-19; examination; imaging; infection; patients; sars cache: cord-350589-h6hotlqk.txt plain text: cord-350589-h6hotlqk.txt item: #2738 of 2876 id: cord-350594-0zxq4lxc author: Patel, Ishan title: Life-Threatening Psoas Hematoma due to Retroperitoneal Hemorrhage in a COVID-19 Patient on Enoxaparin Treated With Arterial Embolization: A Case Report date: 2020-06-25 words: 1830 flesch: 37 summary: Anticoagulation therapy, while indicated in COVID-19 patients, has its own challenges and guidelines describing dosages and indications in this disease are lacking. To the best of our knowledge, we report first case of retroperitoneal hemorrhage due to lumbar artery bleeding in a patient of COVID-19 being treated with enoxaparin, highlighting importance of judicious use of anticoagulation in COVID-19 patients as well as the need of prompt radiological investigation and treatment of bleeding. keywords: anticoagulation; bleeding; covid-19; embolization; patient cache: cord-350594-0zxq4lxc.txt plain text: cord-350594-0zxq4lxc.txt item: #2739 of 2876 id: cord-350639-iguadmw1 author: Padlina, G title: Secondary Cerebrovascular Prevention in Light of the COVID-19 Pandemic date: 2020-08-05 words: 2547 flesch: 38 summary: Our way of providing cerebrovascular secondary prevention at the neurovascular laboratory at the Inselspital, University Hospital of Bern/Switzerland, has been established and adapted over years. Normally, we offer cerebrovascular secondary prevention for patients in both in-and outpatient settings. keywords: covid-19; disease; pandemic; patients; prevention; risk; stroke cache: cord-350639-iguadmw1.txt plain text: cord-350639-iguadmw1.txt item: #2740 of 2876 id: cord-350679-69lv4wbz author: Shinde, Rajesh S. title: To Do or Not to Do?—A Review of Cancer Surgery Triage Guidelines in COVID-19 Pandemic date: 2020-05-11 words: 3480 flesch: 38 summary: Deferring cancer surgeries for this long period may have a direct impact on the long-term outcomes of cancer patients. Due to overall rising cancer incidence and specific concerns, a cohort of cancer patients forms a distinct subset of the population in whom a correct and timely treatment has a huge impact on the outcome. keywords: cancer; cov-2; covid-19; disease; pandemic; patients; sars; surgeries; surgery; treatment cache: cord-350679-69lv4wbz.txt plain text: cord-350679-69lv4wbz.txt item: #2741 of 2876 id: cord-350718-jzliir37 author: Madrazo-González, Z. title: Anemia and transfusion therapy: an update date: 2011-12-31 words: 6505 flesch: 37 summary: The authors considered ABT to be clearly indicated in patients with evidence of hemorrhagic shock, and potentially indicated in cases of acute bleeding associated to hemodynamic instability or an insufficient availability of oxygen -recommending a restrictive transfusion strategy (Hb <7 g/dl) in stable anemia patients, with the possible exception of individuals with myocardial ischemia (level 1 recommendation). Blood transfusions, erythropoiesis-stimulating agents, iron therapy (oral and endovenous) and other therapeutic alternatives must be rationally used, in accordance with the currently available clinical evidence. keywords: abt; anemia; blood; cell; complications; erythropoiesis; esas; hemoglobin; iron; mortality; patients; therapy; transfusion; treatment; use cache: cord-350718-jzliir37.txt plain text: cord-350718-jzliir37.txt item: #2742 of 2876 id: cord-350737-nrtrhq1f author: Chen, Xinchun title: Serology of Severe Acute Respiratory Syndrome: Implications for Surveillance and Outcome date: 2004-04-01 words: 3484 flesch: 42 summary: A virus from the family Coronaviridae, termed SARS coronavirus (SARS CoV), has been identified as the cause [2] [3] [4] [5] [6] [7] , and criteria for laboratory confirmation of SARS CoV infection have been provided by WHO, on the basis of the following methods: (1) detection of SARS CoV RNA by reversetranscription polymerase chain reaction (RT-PCR); (2) serological detection of SARS CoV-related antibody; and (3) isolation of SARS CoV by cell culture [4] . Of 48 patients with suspected SARS CoV infection, 3 (6.3%) were positive for IgG antibody to SARS CoV and 2 (4.2%) were positive for IgM antibody to SARS CoV. SARS CoV sequence published by GenBank (accession numbers gi29826276, gi30027610, and gi30027610). keywords: antibody; cov; igg; infection; patients; sars cache: cord-350737-nrtrhq1f.txt plain text: cord-350737-nrtrhq1f.txt item: #2743 of 2876 id: cord-350904-wyg8ikph author: Gubernatorova, E.O. title: IL-6: relevance for immunopathology of SARS-CoV-2 date: 2020-05-20 words: 8333 flesch: 28 summary: COVID-19 patients also show significant changes in coagulative status (i.e. low platelet count, increased D-dimer, fibrinogen levels) and dysfunction of microvessels in pulmonary circulation [82, 83] , thus, thrombosis of the pulmonary capillaries is believed to contribute to rapidly developing hypoxia. In line with this, recent studies have reported that COVID-19 patients have increased Angiotensin II compared to healthy individuals [103] . keywords: ace2; acute; angiotensin; cells; coronavirus; cov-2; covid-19; cytokine; disease; expression; il-6; immune; infection; lung; patients; receptor; sars; syndrome; virus cache: cord-350904-wyg8ikph.txt plain text: cord-350904-wyg8ikph.txt item: #2744 of 2876 id: cord-350923-532lnnll author: Ramalho, Renata title: Immunometabolism: new insights and lessons from antigen-directed cellular immune responses date: 2020-06-09 words: 17525 flesch: 24 summary: The immunometabolism choreography Immunometabolism in 2017: driving immunity: all roads lead to metabolism Immunometabolism: an emerging frontier A guide to immunometabolism for immunologists Immunometabolism and the land of milk and honey Immunometabolism: cellular metabolism turns immune regulator Metabolic reprogramming in macrophages and dendritic cells in innate immunity Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells Immunometabolism: molecular mechanisms, diseases, and therapies 2016 Immunometabolism: the interface of immune and metabolic responses in disease Toxintriggered interleukin-1 receptor signaling enables early-life discrimination of pathogenic versus commensal skin bacteria Toward a common coordinate framework for the human body Metabolic pathways in immune cell activation and quiescence The cellular and molecular basis of translational immunometabolism Ancillary activity: beyond core metabolism in immune cells Inflammasomes on the crossroads of innate immune recognition and metabolic control Enhancing CD8 T-cell memory by modulating fatty acid metabolism Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development Fatty acid metabolism in the regulation of T cell function Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal Metabolic control of CD8(+) T cell fate decisions and antitumor immunity Oncology meets immunology: the cancer-immunity cycle Similarities and distinctions of cancer and immune metabolism in inflammation and tumors Targeting cancer cell metabolism in pancreatic adenocarcinoma Immunometabolism and the kinome peptide array: a new perspective and tool for the study of gut health Immunometabolism of obesity and diabetes: microbiota link compartmentalized immunity in the gut to metabolic tissue inflammation Nutritional immunology: a multi-dimensional approach Immunonutrition: methodology and applications ) mTOR-and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity The Warburg effect then and now: from cancer to inflammatory diseases Biology of glucose metabolization in cancer cells Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment Cancer metabolism as we know it today: a prologue to a special issue of cancer metabolism Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the Warburg effect in LPS-activated macrophages Macrophages, meta-inflammation, and immuno-metabolism A past and present overview of macrophage metabolism and functional outcomes Krebs cycle rewired for macrophage and dendritic cell effector functions Metabolic pathways in T cell activation and lineage differentiation The return of metabolism: biochemistry and physiology of the pentose phosphate pathway The regulation of the oxidative phase of the pentose phosphate pathway: new answers to old problems Time and demand are two critical dimensions of immunometabolism: the process of macrophage activation and the pentose phosphate pathway Citric acid cycle and role of its intermediates in metabolism De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells Metabolism meets immunity: the role of free fatty acid receptors in the immune system Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation L-Arginine modulates T cell metabolism and enhances survival and anti-tumor activity Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas Arginine metabolism in myeloid cells shapes innate and adaptive immunity Regulation of T cell receptor CD3zeta chain expression by L-arginine Possible role of arginase-1 in concomitant tumor immunity Altered Cd8+ T lymphocyte response triggered by arginase 1: implication for fatigue intensification during localized radiation therapy in prostate cancer patients Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives Metabolism of Larginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives Indoleamine 2, 3-dioxygenase regulation of immune response (review) In fact, cancer cells behave more like activated immune cells with increased biochemical demands and rely on glycolysis for survival [25] keywords: acid; activation; arginine; cachexia; cancer; cancer cells; cells; cycle; effect; expression; fatty; function; glucose; glycolysis; gut; immune; immunonutrition; infections; inflammation; inflammatory; macrophages; metabolism; microbiota; muscle; nutrients; nutrition; patients; production; responses; role; t cells; tissue; tme; tumor cache: cord-350923-532lnnll.txt plain text: cord-350923-532lnnll.txt item: #2745 of 2876 id: cord-350959-bsbz3a1l author: Dovey, Zachary title: Impact of COVID-19 on Prostate Cancer Management: Guidelines for Urologists date: 2020-06-16 words: 5087 flesch: 43 summary: Cancer patients undergoing chemotherapy, including taxanes, have been shown to have an increased risk of viral infections, specifically influenza, which may worsen their morbidity and mortality as a result of immunosuppression caused by the chemotherapy itself Aerosl and surface stability of HCov-19 (SARS-CoV-2) compared to SARS-CoV-2 Modeling the epidemic dynamics and control of COVID-19 Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention Clinical characteristics of coronavirus disease 2019 in China Coronavirus disease 2019 (COVID-19) in Italy Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Sex difference and smoking predisposition in patients with COVID Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection The novel coronavirus 2019 epidemic and kidneys Kidney impairment is associated with in-hospital death of COVID-19 patients. keywords: cancer; coronavirus; cov-2; covid-19; disease; infection; pandemic; patients; pca; prostate; risk; sars; treatment cache: cord-350959-bsbz3a1l.txt plain text: cord-350959-bsbz3a1l.txt item: #2746 of 2876 id: cord-350990-tywbe4o2 author: Checchi, Vittorio title: COVID‐19 dentistry‐related aspects: a literature overview date: 2020-07-05 words: 3725 flesch: 36 summary: Therefore, dental procedures can be considered as one of the most probable causes of Sars-CoV-2 infection because such procedures require close proximity to the patient's mouth, possess a risk of contact with saliva, blood and other biological fluids and involve the use of instrumentation that creates large aerosols 4, 19, 20 . In dental procedures, the mask should be considered as disposable and the mean surgical period does not exceed 2 hours; therefore, it is suggested to use a mask with the highest filtration efficacy without a valve, or a valved mask covered by a surgical mask. keywords: air; coronavirus; cov-2; covid-19; filtration; infection; mask; patients; protection; sars cache: cord-350990-tywbe4o2.txt plain text: cord-350990-tywbe4o2.txt item: #2747 of 2876 id: cord-351020-wde3ki0k author: Allione, Attilio title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-21 words: 675 flesch: 27 summary: key: cord-351020-wde3ki0k authors: Allione, Attilio; Giamello, Jacopo Davide; Paglietta, Giulia; Bernardi, Sara; Cavalot, Giulia title: Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients: comment date: 2020-05-21 journal: Intern Emerg Med DOI: 10.1007/s11739-020-02373-5 sha: doc_id: 351020 cord_uid: wde3ki0k nan In their point-of-view article Switch from oral anticoagulants to parenteral heparin in SARS-CoV-2 hospitalized patients, Testa and colleagues supported the early replacement of oral anticoagulant therapy with heparin in patients hospitalized for Coronavirus disease 2019 (COVID-19) with the exception of those with a mechanical heart valve [1] . In this unpredictable balance, patients on VKA therapy for mechanical heart valves represent an additional and unknown challenge urgently necessitating good-quality evidence. keywords: heparin; patients cache: cord-351020-wde3ki0k.txt plain text: cord-351020-wde3ki0k.txt item: #2748 of 2876 id: cord-351046-yq7287k9 author: Schubert, Gena title: How Much Drool Is Too Much?() date: 2019-12-13 words: 3242 flesch: 45 summary: It is estimated that the risk of myasthenic crisis in myasthenia gravis patients may be as high as 10 to 20%, and 13 to 20% of myasthenia gravis presents with myasthenic crisis as the first manifestation. Approximately 15% of patients with myasthenia gravis are found to have a thymoma. keywords: diagnosis; examination; gravis; myasthenia; normal; patient; ptosis; rate; treatment cache: cord-351046-yq7287k9.txt plain text: cord-351046-yq7287k9.txt item: #2749 of 2876 id: cord-351129-lzzyn570 author: Lee, Jae-Hyun title: Management of Allergic Patients During the COVID-19 Pandemic in Asia date: 2020-06-15 words: 3418 flesch: 40 summary: Coronavirus disease 2019 in Children -United States Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: an ARIA-EAACI statement Atopic dermatitis: Collegium Internationale Allergologicum (CIA) update 2019 Recurrent eczema herpeticum -a retrospective European multicenter study evaluating the clinical characteristics of eczema herpeticum cases in atopic dermatitis patients Safety of dupilumab in severe atopic dermatitis and infection of COVID-19: two case reports The diagnosis and management of acute and chronic urticaria: 2014 update Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis Inpatient care of patients with COVID-19: a guide for hospitalists The use of biologics for immune modulation in allergic disease COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role However, most of the biologics require periodic parenteral/subcutaneous administration, for which such patients have to visit an allergy clinic to receive medications according to a treatment protocol. keywords: asthma; children; covid-19; disease; pandemic; patients; risk; treatment cache: cord-351129-lzzyn570.txt plain text: cord-351129-lzzyn570.txt item: #2750 of 2876 id: cord-351155-5bvo66yb author: Kushner, Tatyana title: Chronic Liver Disease and COVID‐19: Alcohol Use Disorder/Alcohol‐Associated Liver Disease, Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis, Autoimmune Liver Disease, and Compensated Cirrhosis date: 2020-05-21 words: 1807 flesch: 32 summary: 21 Our knowledge of the impact of chronic liver disease on risk and severity of COVID-19 infection, as well as understanding of the COVID-19 pandemic and effect on hepatic disease, will continue to evolve. There are several key issues surrounding COVID-19 infection in patients with cirrhosis, including potentially increased risk for SARS-CoV-2 infection, higher risk for severe disease, and increased risk for hepatic decompensation (Fig. 1) . keywords: covid-19; disease; liver; patients; risk cache: cord-351155-5bvo66yb.txt plain text: cord-351155-5bvo66yb.txt item: #2751 of 2876 id: cord-351184-kcc3p3ow author: Dotters-Katz, Sarah K. title: Considerations for Obstetric Care during the COVID-19 Pandemic date: 2020-04-17 words: 3827 flesch: 47 summary: [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China] (in Chinese) Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 Middle east respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy: report of two cases & review of the literature Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome The association between seasonal influenza-like illness cases and foetal death: a time series analysis Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy Available at Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia COVID-19 in pregnancy: early lessons COVID-19 and Obstetric Care Dotters-Katz Maternal influenza and birth outcomes: systematic review of comparative studies Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome Extracorporeal life support during pregnancy Maternal and infant outcomes among severely ill pregnant and postpartum women with 2009 pandemic influenza A (H1N1)-United States Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn Outpatient Assessment and Management for Pregnant Women With Suspected or Confirmed Novel Coronavirus (COVID-19) American College of Obstetricians and Gynecologists; Public Health Preparedness Expert Work Group. Some centers are not allowing any support persons on labor and delivery units, while others only completely restrict visitation for PUI or confirmed COVID-19 patients. keywords: care; cases; covid-19; delivery; infection; patients; pregnancy; risk; women cache: cord-351184-kcc3p3ow.txt plain text: cord-351184-kcc3p3ow.txt item: #2752 of 2876 id: cord-351195-2fdqu2l1 author: None title: How to manage, after containment, patients with chronic conditions at risk? date: 2020-07-12 words: 434 flesch: 21 summary: The main co-morbidities associated with fatal outcome are diabetes, obesity, chronic respiratory diseases such as chronic obstructive pulmonary disease, renal failure at dialysis stage, cancers under treatment, organ transplant suites, autoimmune diseases with respiratory involvement, multiple sclerosis, high blood pressure and cardiovascular diseases. key: cord-351195-2fdqu2l1 authors: nan title: How to manage, after containment, patients with chronic conditions at risk? date: 2020-07-12 journal: keywords: patients; risk cache: cord-351195-2fdqu2l1.txt plain text: cord-351195-2fdqu2l1.txt item: #2753 of 2876 id: cord-351223-nnuoadh6 author: Pettit, Natasha N. title: Obesity is Associated with Increased Risk for Mortality Among Hospitalized Patients with COVID‐19 date: 2020-06-26 words: 1892 flesch: 46 summary: As we did not evaluate cause of death, we were unable to assess whether there is a common pathway to mortality in COVID-19 patients with obesity. [6] [7] Early reports from Chinese series identified hypertension, diabetes, chronic pulmonary disease, and cardiovascular disease as the comorbidities most consistently associated with hospitalization, respiratory support, intensive care unit (ICU) admission, and death in COVID-19 patients. keywords: admission; covid-19; mortality; obesity; patients cache: cord-351223-nnuoadh6.txt plain text: cord-351223-nnuoadh6.txt item: #2754 of 2876 id: cord-351224-jeedo5mc author: GeurtsvanKessel, Corine H. title: An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment date: 2020-07-06 words: 3049 flesch: 40 summary: key: cord-351224-jeedo5mc authors: GeurtsvanKessel, Corine H.; Okba, Nisreen M. A.; Igloi, Zsofia; Bogers, Susanne; Embregts, Carmen W. E.; Laksono, Brigitta M.; Leijten, Lonneke; Rokx, Casper; Rijnders, Bart; Rahamat-Langendoen, Janette; van den Akker, Johannes P. C.; van Kampen, Jeroen J. A.; van der Eijk, Annemiek A.; van Binnendijk, Rob S.; Haagmans, Bart; Koopmans, Marion title: An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment date: 2020-07-06 journal: The Wantai ELISA detecting total immunoglobulins against the receptor binding domain of SARS CoV-2, has the best overall characteristics to detect functional antibodies in different stages and severity of disease, including the potential to set a cut-off indicating the presence of protective antibodies. keywords: antibodies; antibody; assays; covid-19; disease; patients; population; sars; testing cache: cord-351224-jeedo5mc.txt plain text: cord-351224-jeedo5mc.txt item: #2755 of 2876 id: cord-351340-7y19ystp author: Rao, Gundu H. R. title: Coronavirus Disease and Acute Vascular Events date: 2020-07-31 words: 2561 flesch: 38 summary: They found that circulatory and endocrine comorbidities were common among COVID-19 patients, leading to the conclusion that circulatory diseases remained the most common category of comorbidities. Studies of COVID-19 patients in Wuhan, China, demonstrated that D-dimer levels upon admission >2.0 mg/mL effectively predicted in-hospital mortality. keywords: coronavirus; covid-19; disease; infection; injury; patients; sars cache: cord-351340-7y19ystp.txt plain text: cord-351340-7y19ystp.txt item: #2756 of 2876 id: cord-351431-xcqz9d3t author: Wang, Jun title: Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19 date: 2020-08-18 words: 4524 flesch: 41 summary: The laboratory test of each patient on the day of hospital admission showed that the median neutrophil count in severe COVID-19 patients (3.4, IQR: 1.8-6.7) was higher than in the moderate (3.0, 2.4-3.6) and mild (2.9, 2.3-3.5) groups. In contrast, lymphocyte and monocyte counts in severe COVID-19 patients were lower than in the other two groups ( Principal component analysis was performed to visualize the contribution of all mentioned clinical parameters on disease severity (Figure 2A) . keywords: analysis; cases; cells; counts; covid-19; figure; genes; lung; nets; neutrophil; patients cache: cord-351431-xcqz9d3t.txt plain text: cord-351431-xcqz9d3t.txt item: #2757 of 2876 id: cord-351446-j4ambec5 author: Sinonquel, P. title: COVID‐19 and gastrointestinal endoscopy: what should be taken into account? date: 2020-04-26 words: 2675 flesch: 40 summary: We recommend these 'assistants' to be experienced In low risk or confirmed COVID-19 negative patients this buddy system is not required and the endoscopist can be assisted by one (or more) endoscopic nurse without taking the enhanced but only the standard PPE and infection control measures. Low risk patients are patients with no risk factors and no symptoms or at least 1 positive risk factor but a negative laboratory RT-PCR test. keywords: cov-2; covid-19; endoscopy; patient; procedure; risk; sars cache: cord-351446-j4ambec5.txt plain text: cord-351446-j4ambec5.txt item: #2758 of 2876 id: cord-351457-fzj3ciif author: Vezzoli, Pamela title: Cutaneous lupus erythematosus patients in a high‐epidemic COVID‐19 area, Bergamo, Italy date: 2020-06-07 words: 580 flesch: 35 summary: 3, 4 Indeed, infections remain a leading cause of mortality in lupus patients. 5 Recently, some authors reported the importance to maintain disease remission in lupus patients, especially in high-epidemic areas, avoiding unnecessary emergency room visits and hospitalization. keywords: covid-19; patients cache: cord-351457-fzj3ciif.txt plain text: cord-351457-fzj3ciif.txt item: #2759 of 2876 id: cord-351528-23lbs8al author: Zacharia, Brad E title: Letter: Surgical Management of Brain Tumor Patients in the COVID-19 Era date: 2020-04-29 words: 1000 flesch: 28 summary: Expeditious but safe discharges can conserve hospital beds for COVID-19 patients. In regions with high baseline COVID-19 rates and available testing, all patients should undergo testing as close as possible to surgery. keywords: airway; covid-19; patients; testing cache: cord-351528-23lbs8al.txt plain text: cord-351528-23lbs8al.txt item: #2760 of 2876 id: cord-351531-wo1ggmmn author: Giustiniano, Enrico title: Trans-thoracic Echocardiography in Prone Positioning COVID-19 Patients: a Small Case Series date: 2020-09-15 words: 2570 flesch: 40 summary: The main result of our retrospective analysis is that TTE can be performed in patients in prone positioning and is reliable and repeatable; the single apical-four-chamber view provides sufficient data to evaluate the cardiac performance in case of scarce availability of hemodynamic monitoring devices, like in a pandemic setting. Among survivors, the mean The main results of our retrospective analysis on a small cases series consisted of few main points: (1) TTE can be performed in patients in prone positioning and is reliable in comparison with the supine TTE and repeatable, meaning that it may be used also to monitor the cardiac function every time it is needed, in a standardized way (i.e., without any minimal changing of the patient position, during both supine and prone positioning); the single apical-four-chamber view provides sufficient data to evaluate the cardiac performance in case of scarce availability of hemodynamic monitoring devices, like in a pandemic setting; (2) according to recent scientific reports, prone positioning in patients suffering from ARDS due to COVID-19 pneumonia is not always effective. keywords: covid-19; echocardiography; patients; positioning; tte cache: cord-351531-wo1ggmmn.txt plain text: cord-351531-wo1ggmmn.txt item: #2761 of 2876 id: cord-351555-hsgsuor2 author: Constantinou, Constantina title: Developing a holistic contingency plan: Challenges and dilemmas for cancer patients during the COVID‐19 date: 2020-07-20 words: 7598 flesch: 41 summary: key: cord-351555-hsgsuor2 authors: Constantinou, Constantina; Kolokotroni, Ourania; Mosquera, Maria‐Cecilia; Heraclides, Alexandros; Demetriou, Christiana; Karayiannis, Peter; Quattrocchi, Annalisa; Charalambous, Andreas title: Developing a holistic contingency plan: Challenges and dilemmas for cancer patients during the COVID‐19 date: 2020-07-20 journal: Cancer Med DOI: 10.1002/cam4.3271 sha: doc_id: 351555 cord_uid: hsgsuor2 During the first quarter of 2020 the world is experiencing a pandemic of Severe Acute Respiratory Syndrome‑Coronavirus‑2 (SARS‑CoV‑2), a novel beta coronavirus that is responsible for the 2019 novel coronavirus disease (COVID‐19). The COVID‐19 pandemic revealed that healthcare systems around the world were not prepared to deal with either the direct effects of the pandemic or with the indirect effects that are imposed on the health of patients with chronic disorders such as cancer patients. keywords: addition; cancer; cancer patients; care; coronavirus; covid-19; disease; healthcare; management; pandemic; patients; risk; sars; treatment cache: cord-351555-hsgsuor2.txt plain text: cord-351555-hsgsuor2.txt item: #2762 of 2876 id: cord-351597-bdazrbsz author: Thalappillil, Richard title: POCUS to guide fluid-therapy in COVID-19 date: 2020-05-06 words: 509 flesch: 30 summary: Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network Utility of Point-of-Care Lung Ultrasound for Initial Assessment of Acute Respiratory Distress Syndrome Patients in the Emergency Department Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis Prone Positioning in Severe Acute Respiratory Distress Syndrome Lung ultrasound after placing patient in prone position demonstrates significant B lines (arrows) consistent with acute respiratory distress syndrome, however with improved aeration. keywords: fluid; lung cache: cord-351597-bdazrbsz.txt plain text: cord-351597-bdazrbsz.txt item: #2763 of 2876 id: cord-351604-x4rsdwqz author: González-Gay, Miguel A. title: BioLogic THERAPY IN COVID-19 date: 2020-06-26 words: 1503 flesch: 32 summary: In summary, based on our experience in the management of autoimmune diseases with biologic therapies and new small molecules, we strongly support the use of these agents in COVID-19 patients with severe disease or in those patients who experience a rapid deterioration due to the development of a MAS-like hyperinflammatory state. Since the antiinflammatory effect of IVIg predominates over its immunosuppressive effect 15 , as occurred with autoimmune diseases where it is difficult to establish a differential diagnosis between autoinflammatory/autoimmune disease and intercurrent infections, IVIg therapy may be considered in COVID-19 patients with bacterial superinfection associated. keywords: anti; covid-19; disease; patients; syndrome cache: cord-351604-x4rsdwqz.txt plain text: cord-351604-x4rsdwqz.txt item: #2764 of 2876 id: cord-351625-1we9wi1g author: Han, Huan title: Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients date: 2020-10-07 words: 4069 flesch: 42 summary: These results suggest that asymptomatic COVID-19 patients had normal clinical indicators and faster viral clearance than symptomatic patients. Our results demonstrate that asymptomatic COVID-19 patients have better outcomes than symptomatic patients. keywords: asymptomatic; cell; counts; covid-19; disease; liver; patients; sars cache: cord-351625-1we9wi1g.txt plain text: cord-351625-1we9wi1g.txt item: #2765 of 2876 id: cord-351722-3mw1te94 author: Recalde, M. title: Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom date: 2020-09-03 words: 5301 flesch: 47 summary: Among obese COVID-19 patients, fatality was higher than among obese influenza patients (range: 0·1% to 3%). Although obese COVID-19 patients were younger and less likely to have comorbidities than obese influenza patients in the hospitalized cohorts, they more frequently had adverse outcomes. keywords: comorbidities; covid-19; influenza; medrxiv; obese; obesity; patients; preprint cache: cord-351722-3mw1te94.txt plain text: cord-351722-3mw1te94.txt item: #2766 of 2876 id: cord-351735-x1lng449 author: Flikweert, Antine W. title: Late histopathologic characteristics of critically ill COVID-19 patients: Different phenotypes without evidence of invasive aspergillosis, a case series date: 2020-07-08 words: 2685 flesch: 34 summary: Often an atypical high compliance phenotype (L-type) is observed during mechanical ventilation in COVID-19 patients in contrast to mechanical ventilation characteristics typically seen in ARDS with low lung compliance phenotype (H -type). The cumulative incidence of venous thromboembolism reported was 49% in COVID-19 patients admitted to the ICU. keywords: aspergillosis; case; covid-19; icu; organizing; patients; pneumonia cache: cord-351735-x1lng449.txt plain text: cord-351735-x1lng449.txt item: #2767 of 2876 id: cord-351762-n95ar9ci author: Wang, Brian Xiangzhi title: Susceptibility and prognosis of COVID-19 patients with cardiovascular disease date: 2020-06-25 words: 1497 flesch: 42 summary: Importantly, this study also supported the notion that patients with CVDs were more likely to suffer severe illnesses from COVID-19 infection-10.5% of patients with CVDs and 6.0% with hypertension died, compared with the 0.9% in patients with no comorbidities. key: cord-351762-n95ar9ci authors: Wang, Brian Xiangzhi title: Susceptibility and prognosis of COVID-19 patients with cardiovascular disease date: 2020-06-25 journal: keywords: covid-19; disease; patients; study cache: cord-351762-n95ar9ci.txt plain text: cord-351762-n95ar9ci.txt item: #2768 of 2876 id: cord-351776-otx5qwyu author: Ibáñez-Samaniego, Luis title: Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19 date: 2020-06-21 words: 3897 flesch: 41 summary: FIB-4 ≥2.67 defined patients with risk for advanced liver fibrosis. Advanced liver fibrosis is the main determinant of progression to cirrhosis, liver failure, and hepatocellular carcinoma keywords: ast; covid-19; disease; fibrosis; liver; patients; risk; study cache: cord-351776-otx5qwyu.txt plain text: cord-351776-otx5qwyu.txt item: #2769 of 2876 id: cord-351819-ovpz36e7 author: Beyrouti, Rahma title: Characteristics of ischaemic stroke associated with COVID-19 date: 2020-04-30 words: 1477 flesch: 39 summary: In five of six patients, ischaemic stroke occurred 8-24 days after Covid-19 symptom onset, and in one patient during the presymptomatic phase, suggesting that COVID-19 associated ischaemic stroke is usually delayed, but can occur both early and later in the course of the disease. Screening for aPL might be reasonable in patients with COVID-19 associated ischaemic stroke, although their pathogenic relevance remains uncertain. keywords: covid-19; dimer; patients; stroke cache: cord-351819-ovpz36e7.txt plain text: cord-351819-ovpz36e7.txt item: #2770 of 2876 id: cord-351823-ldbscq4s author: Leung, Marco Shiu Tsun title: COVID‐19 and Oncology: Service transformation during pandemic date: 2020-08-18 words: 5555 flesch: 46 summary: 29 Clinical characteristics in cancer patients with COVID-19 do not differ to the non-cancer population and includes the following and summarized in Table 3 . 2 T A B L E Early data from Wuhan, China in an analysis of 105 patients whose outcomes were matched with 536 control patients showed that in the cancer population, Lung cancer was the most frequent malignancy followed by gastrointestinal, breast, or thyroid, then hematological malignancy; compared with the noncancer control population, cancer patients had higher death rates, ICU admission rates, a greater likelihood of severe symptoms and a doubled chance of requiring invasive mechanical ventilation; however, cancer patients also were more often smokers and experienced more in-hospital infections, which may have been contributing factors to the statistical differences. keywords: cancer; care; coronavirus; covid-19; health; nhs; oncology; pandemic; patients; services; treatment cache: cord-351823-ldbscq4s.txt plain text: cord-351823-ldbscq4s.txt item: #2771 of 2876 id: cord-351825-fdog73g2 author: Tsai, Cheng-Yu title: A Novel Non-contact Self-Injection-Locked Radar for Vital Sign Sensing and Body Movement Monitoring in COVID-19 Isolation Ward date: 2020-08-26 words: 1527 flesch: 54 summary: Therefore we attempted to share the experience and try to apply this equipment in COVID-19 patients in future to offer the more reliable and safe policy. This instrument has been used on COVID-19 patients as an auxiliary monitor system in the isolation ward. keywords: covid-19; patient; radar; rate cache: cord-351825-fdog73g2.txt plain text: cord-351825-fdog73g2.txt item: #2772 of 2876 id: cord-351896-j6h02ab5 author: Ghannam, Malik title: Neurological involvement of coronavirus disease 2019: a systematic review date: 2020-06-19 words: 5067 flesch: 30 summary: Cytokine and anticytokine interventions Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity Guillain-Barré Syndrome Is COVID-19 a proteiform disease inducing also molecular mimicry phenomena? Steroid-responsive encephalitis in Covid-19 disease Immune thrombocytopenic purpura in a patient with Covid-19 Autoimmune haemolytic anaemia associated with COVID-19 infection The genetic sequence, origin, and diagnosis of SARS-CoV-2 Multiple organ infection and the pathogenesis of SARS Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease Dysregulation of immune response in patients with COVID-19 in Wuhan, China The COVID-19 pandemic: consideration for brain infection Isolated sudden onset anosmia in COVID-19 infection. D-dimers might play a major prothrombotic role in COVID-19 patients. keywords: acute; coronavirus; covid-19; infection; n =; patients; review; sars; stroke; syndrome cache: cord-351896-j6h02ab5.txt plain text: cord-351896-j6h02ab5.txt item: #2773 of 2876 id: cord-352065-960xqft4 author: Rello, Jordi title: Update in COVID-19 in the Intensive Care Unit from the 2020 HELLENIC Athens International Symposium date: 2020-10-22 words: 4979 flesch: 32 summary: Regarding detection and diagnosis, studies have used machine learning algorithms to predict the criticality of COVID-19 positive patients using clinical features and identifying which of them have statistically significant hazard errors [64, 65] . COVID-19 infection has shown a great variability in terms of mortality in different regions around the globe. keywords: coronavirus; cov-2; covid-19; disease; icu; infection; lung; pandemic; patients; phenotype; pneumonia; sars cache: cord-352065-960xqft4.txt plain text: cord-352065-960xqft4.txt item: #2774 of 2876 id: cord-352159-qx16i7s1 author: Pettit, Natasha N. title: Late Onset Infectious Complications and Safety of Tocilizumab in the Management of COVID‐19 date: 2020-08-13 words: 3331 flesch: 44 summary: We sought to evaluate the incidence of these potential complications following the use of TCZ among COVID-19 patients. TCZ use was avoided in patients with confirmed or suspected bacterial infections, neutropenia, thrombocytopenia, or if liver function tests (LFTs) were > 10x upper limit of normal. keywords: control; covid-19; dose; group; infections; patients; tcz cache: cord-352159-qx16i7s1.txt plain text: cord-352159-qx16i7s1.txt item: #2775 of 2876 id: cord-352177-05sku8a8 author: Pahus, Laurie title: Patient distrust in pharmaceutical companies: an explanation for women under-representation in respiratory clinical trials? date: 2020-08-13 words: 4118 flesch: 31 summary: Specifically, we sought to evaluate if distrust in pharmaceutical companies and associated psychosocial factors could represent a recruitment bias in clinical trials and thus threaten the applicability of their results. The recruitment and retention of patients in clinical trials is challenging, but necessary, because it is the cornerstone of medical evidence production. keywords: companies; distrust; industry; participate; patients; pharmaceutical; research; study; trials; willingness cache: cord-352177-05sku8a8.txt plain text: cord-352177-05sku8a8.txt item: #2776 of 2876 id: cord-352193-izzqdg3v author: Allen, M. title: Organising outpatient dialysis services during the COVID-19 pandemic. A simulation and mathematical modelling study. date: 2020-04-27 words: 4281 flesch: 52 summary: Results If current outpatient capacity is maintained there is sufficient capacity in the South of England to keep COVID-19 negative/recovered and positive patients in separate sessions, but rapid reallocation of patients may be needed (as sessions are cleared of negative/recovered patients to enable that session to be dedicated to positive patients). If current outpatient capacity is maintained there is sufficient capacity in the South of England to keep COVID-19 negative/recovered and positive patients in separate sessions, but rapid reallocation of patients may be needed (as sessions are cleared of negative/recovered patients to enable that session to be dedicated to positive patients). keywords: capacity; covid; covid-19; dialysis; model; patients; time; transport cache: cord-352193-izzqdg3v.txt plain text: cord-352193-izzqdg3v.txt item: #2777 of 2876 id: cord-352215-dhkvh45t author: Ramachandran, Preethi title: Increased serum aminotransferase activity and clinical outcomes in Coronavirus disease 2019 date: 2020-06-30 words: 2544 flesch: 40 summary: [AST]/alanine aminotransferase [ALT]) is commonly noted among COVID-19 patients. We retrospectively evaluated hospitalized COVID-19 patients with clinically significant elevated aminotransferases (defined as >2 times upper limit of normal) and compared them with COVID-19 patients without an elevation in aminotransferases. keywords: aminotransferases; covid-19; disease; liver; patients; study cache: cord-352215-dhkvh45t.txt plain text: cord-352215-dhkvh45t.txt item: #2778 of 2876 id: cord-352227-827987jf author: Chernevskaya, Ekaterina title: Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study date: 2020-06-08 words: 6464 flesch: 41 summary: Blood (from a central venous catheter) and gut microbiome samples were collected in the morning at regular intervals: in ACI patients-on days 1, 3, and 7-9 after the diagnosis of pneumonia; in CCI patients-once a week for a month. To compare serum metabolite levels, we used serum samples from 23 healthy volunteers (for 5 of them, fecal samples were also collected on the same day). keywords: acid; amm; associations; cci; feces; group; gut; levels; metabolites; microbial; microbiota; patients; serum cache: cord-352227-827987jf.txt plain text: cord-352227-827987jf.txt item: #2779 of 2876 id: cord-352234-utjne1ef author: Mendlovic, Joseph title: Internal medicine patients admitted without COVID‐19 during the outbreak date: 2020-08-11 words: 1744 flesch: 50 summary: As a result of the increase in COVID-19 patients, closure of IM wards, re-assignment of staff, and dynamic changes in available community placement options, we investigated the impact of the outbreak on IM patients not admitted for COVID-19. Proper planning allowed SZ to remain functional and even shorten IM patient length of stay. keywords: covid-19; outbreak; patients; wards cache: cord-352234-utjne1ef.txt plain text: cord-352234-utjne1ef.txt item: #2780 of 2876 id: cord-352302-are8vvhh author: Hartman, W. title: Hospitalized COVID-19 patients treated with Convalescent Plasma in a mid-size city in the midwest date: 2020-06-22 words: 3139 flesch: 50 summary: Methods Hospitalized COVID-19 patients categorized as having Severe or Life-Threatening disease according to the Mayo Clinic Emergency Access Protocol were screened, consented, and treated with convalescent plasma collected from local donors recovered from COVID-19 infection. While larger cities like New York City and Seattle were experiencing large surges in the volume of critically ill patients in their health systems, the health care system in Madison saw relatively modest numbers of COVID-19 patients. keywords: covid-19; disease; life; patients; plasma; preprint cache: cord-352302-are8vvhh.txt plain text: cord-352302-are8vvhh.txt item: #2781 of 2876 id: cord-352304-tt2q5mgs author: Sun, Dan title: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study date: 2020-03-19 words: 3241 flesch: 48 summary: On entering the outbreak stage and improvement of pathogen detection, pediatric patients (even newborns) have been reported increasingly Children have special immune response system which is distinct from adults [19] ; therefore, pediatric patients with COVID-19 have their own clinical features and therapeutic responses [20] . keywords: coronavirus; covid-19; disease; february; patients; sars; wuhan cache: cord-352304-tt2q5mgs.txt plain text: cord-352304-tt2q5mgs.txt item: #2782 of 2876 id: cord-352399-2xfzpw9m author: Hearn, Jason title: Lived Experiences and Technological Literacy of Heart Failure Patients and Clinicians at a Cardiac Care Centre in Uganda date: 2020-07-28 words: 4801 flesch: 48 summary: To engage Ugandan HF patients and clinicians regarding their experiences with HF management and technology, so as to inform the future design of a digital health intervention for HF patients in Uganda. One such intervention, which was developed alongside HF patients and clinicians living in Canada, has been shown to improve patient self-care and quality of life amongst Canadian HF patients [19, 20] . keywords: care; clinic; clinicians; health; heart; mobile; patients; self cache: cord-352399-2xfzpw9m.txt plain text: cord-352399-2xfzpw9m.txt item: #2783 of 2876 id: cord-352401-tmt1pmw9 author: Curatola, Antonietta title: Use of Handheld Transceiver for Hospital Healthcare Workers-Caregiver Communication During the Coronavirus disease 2019 (COVID-19) Outbreak in Pediatric Emergency Department date: 2020-04-13 words: 992 flesch: 50 summary: 4 Our hospital tried to adapt to COVID-19 health emergency in a short time. The transmission of the 2019-nCov infection happened through the respiratory droplets by infected patients, but coronavirus can also be transmitted by contact with contaminated objects, such as phones, toys and doorknobs 3 ; however, also asymptomatic cases play a critical role in the transmission process. keywords: cases; coronavirus; covid-19 cache: cord-352401-tmt1pmw9.txt plain text: cord-352401-tmt1pmw9.txt item: #2784 of 2876 id: cord-352544-7b6btzrx author: Liu, Zhelong title: The association of diabetes and the prognosis of COVID-19 patients: a retrospective study date: 2020-08-25 words: 3293 flesch: 42 summary: key: cord-352544-7b6btzrx authors: Liu, Zhelong; Bai, Xi; Han, Xia; Jiang, Wangyan; Qiu, Lin; Chen, Shi; Yu, Xuefeng title: The association of diabetes and the prognosis of COVID-19 patients: a retrospective study date: 2020-08-25 journal: Diabetes Res Clin Pract DOI: 10.1016/j.diabres.2020.108386 sha: doc_id: 352544 cord_uid: 7b6btzrx Abstract Aims This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs on the prognosis of COVID-19 patients with diabetes. Data regarding the impact of diabetes on the prognosis of COVID-19 patients are scant and controversial. keywords: covid-19; diabetes; hba1c; patients; risk; worsening cache: cord-352544-7b6btzrx.txt plain text: cord-352544-7b6btzrx.txt item: #2785 of 2876 id: cord-352557-l7sahv5t author: Takla, Michael title: Chloroquine, hydroxychloroquine, and COVID-19: systematic review and narrative synthesis of efficacy and safety date: 2020-11-13 words: 7595 flesch: 34 summary: 10% of HCQ patients experienced averse ECG modifications requiring cessation of treatment after a median of 4 days. HCQ patients had lower prevalence of comorbidities, except hepatic cirrhosis. keywords: control; covid-19; covid-19 patients; data; day; et al; evidence; hcq; hydroxychloroquine; patients; safety; studies; study; treatment cache: cord-352557-l7sahv5t.txt plain text: cord-352557-l7sahv5t.txt item: #2786 of 2876 id: cord-352577-h3652seb author: Kopić, Jasminka title: Expanding the Use of Noninvasive Ventilation During an Epidemic date: 2014-08-27 words: 3341 flesch: 29 summary: Importantly, in a retrospective analysis comparing the efficacy of NIV against invasive ventilation in SARS patients with respiratory failure, Yam et al reported that no HCW caring for NIV patients was infected and that standard personal protective equipment, including surgical masks, was as effective as the more sophisticated protective equipment used later in the outbreak. We discuss NIV use during epidemics and indicate the need for prospective randomized clinical studies on the efficacy of NIV in epidemic conditions to provide important information to the current body of literature. keywords: care; epidemic; failure; niv; patients; respiratory; use; ventilation cache: cord-352577-h3652seb.txt plain text: cord-352577-h3652seb.txt item: #2787 of 2876 id: cord-352579-ndcbmgfj author: Takahashi, Takuto title: Pharmacogenomics of COVID-19 therapies date: 2020-08-18 words: 5264 flesch: 28 summary: In conclusion, although direct evidence in COVID-19 patients is lacking, we identified potential actionable genetic markers in COVID-19 therapies. Clinical studies in COVID-19 patients are deemed warranted to assess potential roles of these markers. keywords: azithromycin; covid-19; drug; hydroxychloroquine; lopinavir; patients; pharmacogenomics; ribavirin; risk; tocilizumab; treatment; use; variants cache: cord-352579-ndcbmgfj.txt plain text: cord-352579-ndcbmgfj.txt item: #2788 of 2876 id: cord-352678-8f2ygul2 author: Prasad, Ashish title: Single Virus Targeting Multiple Organs: What We Know and Where We Are Heading? date: 2020-08-05 words: 3497 flesch: 40 summary: In another study with COVID-19 patients in China, an early response of IgA instead of IgG was observed in the humoral immune response against SARS-CoV-2 (11) . It has been observed that 5% of COVID-19 patients become critically ill with severe pneumonia and multiple-organ damage and cytokine storm might be a possible explanation for such an observation. keywords: coronavirus; cov-2; covid-19; disease; infection; patients; sars; symptoms; virus cache: cord-352678-8f2ygul2.txt plain text: cord-352678-8f2ygul2.txt item: #2789 of 2876 id: cord-352823-1os3kwp1 author: Zeng, Hui title: The strategies of perioperative management in orthopedic department during the pandemic of COVID-19 date: 2020-10-15 words: 3075 flesch: 41 summary: We had benefited from the strict flowcharts, smart robot, and protection equipment during the perioperative managements for orthopedic patients. Reasonable treatment strategies were changed and adopted timely to minimize the adverse effects on the treatment of orthopedic patients during the epidemic. keywords: covid-19; epidemic; hospital; operation; orthopedic; patients; staff; treatment cache: cord-352823-1os3kwp1.txt plain text: cord-352823-1os3kwp1.txt item: #2790 of 2876 id: cord-352828-4ecik6xw author: Lagziel, Tomer title: Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) date: 2020-05-19 words: 2442 flesch: 38 summary: Treatment of skin drug reactions has the additional challenge of the unknown effects of systemic steroids, which has been a mainstay of treatment for these conditions in COVID-19 positive patients [16] . In addition, the burn unit lacks negative pressure rooms suited for COVID-19 patients. keywords: burn; covid-19; patient; results; syndrome; test cache: cord-352828-4ecik6xw.txt plain text: cord-352828-4ecik6xw.txt item: #2791 of 2876 id: cord-352846-p7hhv297 author: Bryson, Ethan O. title: A strategy for management of ECT patients during the COVID-19 pandemic date: 2020-05-12 words: 2266 flesch: 48 summary: No prior disease outbreak has affected the practice of ECT in the way that this current pandemic has, and at present little is known regarding optimal strategies for reduction of disease transmission during ECT treatment. Like any hospital-based procedure, anyone involved with caring for patients receiving ECT could potentially be exposed to this highly contagious virus. keywords: covid-19; ect; health; patients; treatment cache: cord-352846-p7hhv297.txt plain text: cord-352846-p7hhv297.txt item: #2792 of 2876 id: cord-352889-fl61z3w3 author: Downs, John B. title: Proposal for Coronavirus Disease 2019 Management date: 2020-05-12 words: 2707 flesch: 32 summary: PATIENTS: Patients with coronavirus disease 2019 are presenting with early respiratory distress and hypoxemia, but not hypercapnia. Patients who maintain adequate alveolar ventilation, normocapnia, and adequate oxygenation may avoid the need for tracheal intubation. keywords: care; cpap; need; patients; pressure; ventilation cache: cord-352889-fl61z3w3.txt plain text: cord-352889-fl61z3w3.txt item: #2793 of 2876 id: cord-352901-ia34l2ml author: Natalello, Gerlando title: Nailfold capillaroscopy findings in patients with coronavirus disease 19: Broadening the spectrum of covid-19 microvascular involvement() date: 2020-09-17 words: 3664 flesch: 27 summary: Our aim was to assess microvasculature through nailfold videocapillaroscopy (NVC) in COVID-19 patients. COVID-19 patients present microvascular abnormalities at NVC. keywords: acute; alterations; capillaries; covid-19; microvascular; nailfold; nvc; patients cache: cord-352901-ia34l2ml.txt plain text: cord-352901-ia34l2ml.txt item: #2794 of 2876 id: cord-352905-ge3u32hm author: Galimberti, Sara title: Tyrosine Kinase Inhibitors Play an Antiviral Action in Patients Affected by Chronic Myeloid Leukemia: A Possible Model Supporting Their Use in the Fight Against SARS-CoV-2 date: 2020-09-02 words: 5398 flesch: 33 summary: Firstly, the infection and replication rate of torquetenovirus (TTV), whose load is inversely proportional to the host immunological control, have been measured in CML patients receiving nilotinib. Consequently, in our opinion, the very low percentage of CML patients found to be SARS-CoV-2 positive could be not explained by the inability of the virus to attack the host cells. keywords: abl1; cells; cml; coronavirus; covid-19; imatinib; load; patients; sars; study; treatment; ttv; virus cache: cord-352905-ge3u32hm.txt plain text: cord-352905-ge3u32hm.txt item: #2795 of 2876 id: cord-352914-jccxzit1 author: Sanz Herrero, Francisco title: Methylprednisolone added to tocilizumab reduces mortality in SARS‐CoV‐2 pneumonia: An observational study date: 2020-06-30 words: 1270 flesch: 39 summary: Effective treatment of severe COVID-19 patients with tocilizumab Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis Clinical features of patients infected with 2019 novel coronavirus in Wuhan Effects of early corticosteroid treatment on plasma SARSassociated Coronavirus RNA concentrations in adult patients Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 For this reason, we included methylprednisolone treatment in the local guidelines of our center based on the study by Wu et al keywords: methylprednisolone; patients; tocilizumab; treatment cache: cord-352914-jccxzit1.txt plain text: cord-352914-jccxzit1.txt item: #2796 of 2876 id: cord-352937-htmp0avc author: Chow, Velda Ling Yu title: Recommendations for surgical management of recurrent nasopharyngeal carcinoma during COVID‐19 pandemic date: 2020-06-13 words: 2361 flesch: 35 summary: Laryngoscope Next-generation surgical navigation systems in sinus and skull base surgery Early results of robotic assisted nasopharyngectomy for recurrent nasopharyngeal carcinoma Combined transnasal endoscopic and transoral robotic resection of recurrent nasopharyngeal carcinoma Letter: Precautions for endoscopic transnasal skull base surgery during the COVID-19 pandemic Safety recommendations for evaluation and surgery of the head and neck during the COVID-19 pandemic Conservation of personal protective equipment for head and neck cancer surgery during COVID-19 pandemic Endoscopic skull base and transoral surgery during the COVID-19 pandemic: minimizing droplet spread with a negative-pressure otolaryngology viral isolation drape (NOVID) Multivariate analysis of prognostic factors for salvage nasopharyngectomy via the maxillary swing approach Surgical salvage of recurrent T3 nasopharyngeal carcinoma: prognostic significance of clivus, maxillary, temporal and sphenoid bone invasion Surgical salvage for recurrent retropharyngeal lymph node metastasis in nasopharyngeal carcinoma Extracranial/intracranial vascular bypass and craniofacial resection: new hope for patients with locally advanced recurrent nasopharyngeal carcinoma Quality of life and survival outcome for patients with nasopharyngeal carcinoma treated by volumetric-modulated arc therapy versus intensity-modulated radiotherapy Silent aspiration and swallowing physiology after radiotherapy in patients with nasopharyngeal carcinoma Quality of life of patients after salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma Recommendations for surgical management of recurrent nasopharyngeal carcinoma during Comprehensive preoperative work‐up, careful patient selection, attention to details perioperation and multidisciplinary approach is essential in ensuring optimal outcomes after salvage surgery for recurrent nasopharyngeal carcinoma patients. keywords: carcinoma; covid-19; disease; patients; salvage; surgery; transmission cache: cord-352937-htmp0avc.txt plain text: cord-352937-htmp0avc.txt item: #2797 of 2876 id: cord-352969-rpt7xja6 author: Kataria, Ashish title: COVID-19 in Kidney Transplantation: Epidemiology, Management Considerations, and the Impact on Kidney Transplant Practice date: 2020-07-15 words: 5980 flesch: 38 summary: 19 Reverse-transcription polymerase chain reaction (RT-PCR) assay of upper respiratory secretions usually collected with a nasopharyngeal swab is the current diagnostic test of choice for COVID-19 patients. COVID-19 patients have been reported to develop profound lymphopenia. keywords: coronavirus; covid-19; data; disease; kidney; ktrs; patients; population; recipients; sars; studies; study; transplant cache: cord-352969-rpt7xja6.txt plain text: cord-352969-rpt7xja6.txt item: #2798 of 2876 id: cord-353004-ocnp758o author: Prakash, Lakshmanan title: COVID-19 in the operating room: a review of evolving safety protocols date: 2020-07-20 words: 4379 flesch: 46 summary: Theoretically, viremia in patients with asymptomatic or confirmed COVID-19 patients could pose a risk of transmissibility to the orthopedic team during aerosolized-blood generating procedures. Health Leaders Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan Surgery in COVID-19 patients: operational directives Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection Immune function after major surgical interventions: the effect of postoperative pain treatment Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome Chemokine up-regulation in SARS-coronavirus-infected, monocytederived human dendritic cells Neurosurgeon dies of COVID-19. keywords: coronavirus; covid-19; pandemic; patients; procedures; room; staff; surgeons; surgery cache: cord-353004-ocnp758o.txt plain text: cord-353004-ocnp758o.txt item: #2799 of 2876 id: cord-353013-7cx0gnum author: DENG, Pengbo title: Bronchial Fistula: Rare Complication of Treatment with Anlotinib date: 2020-10-20 words: 4364 flesch: 51 summary: We aim to report 3 cases of rare complication of anlotinib-bronchial fistula (BF) during the treatment of lung cancer patients and summarize the possible causes. BPF is more common in lung cancer patients after surgery, directly caused by lung cancer invasion is rarely reported which usually combined with infection [15] . keywords: anlotinib; cancer; cell; fistula; line; lung; patients; treatment; tumor cache: cord-353013-7cx0gnum.txt plain text: cord-353013-7cx0gnum.txt item: #2800 of 2876 id: cord-353059-39msyuxb author: Chroboczek, T. title: Beneficial effect of corticosteroids in severe COVID-19 pneumonia: a propensity score matching analysis. date: 2020-05-13 words: 3478 flesch: 44 summary: https://doi.org/10.1101/2020.05.08.20094755 doi: medRxiv preprint Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical Features of 69 Cases with Coronavirus Disease A Novel Coronavirus from Patients with Pneumonia in China A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19 Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia Detectable serum SARS-CoV-2 viral load COVID-19: consider cytokine storm syndromes and immunosuppression Effective treatment of severe COVID-19 patients with tocilizumab Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in patients with severe COVID-19 Clinical Outcomes of Hydroxychloroquine in Hospitalized Patients with COVID-19: In our hospital, the ICU is usually composed of 15 beds only; at the peak of the first wave of the pandemic, it required deep reorganization, and extension of its capacity to 35 beds, due to the strong increase in the number of COVID-19 ventilated patients. keywords: covid-19; license; medrxiv; patients; preprint; study; treatment cache: cord-353059-39msyuxb.txt plain text: cord-353059-39msyuxb.txt item: #2801 of 2876 id: cord-353180-hbwrzm6s author: Umoren, Rachel A. title: In-Hospital Telehealth Supports Care for Neonatal Patients in Strict Isolation date: 2020-04-08 words: 2017 flesch: 40 summary: These findings are likely reflective of the number of health care providers, learners, and supportive staff involved in patient care at a large academic center. Telehealth supports patient care in isolation. keywords: care; isolation; patient; services; telemedicine cache: cord-353180-hbwrzm6s.txt plain text: cord-353180-hbwrzm6s.txt item: #2802 of 2876 id: cord-353200-5csewb1k author: Jehi, Lara title: Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19 date: 2020-08-11 words: 4349 flesch: 35 summary: After that date, testing resources were streamlined through a COVID-19 Hotline which followed recommendations from the Centers for Disease Control (recommending to focus on high risk patients as defined by any of the following: Age older than 60 years old or less than 36 months old; on immune therapy; having comorbidities of cancer, end-stage renal disease, diabetes, hypertension, coronary artery disease, heart failure with reduced ejection fraction, lung disease, HIV/AIDS, solid organ transplant; contact with known COVID 19 patients; physician discretion was still allowed). Table 1 provides demographic, exposure, clinical, laboratory, social characteristics, and medication history of COVID-19 patients who were hospitalized versus those who completed their treatment on an outpatient basis in both the DC and VC. keywords: cohort; covid-19; data; disease; health; hospitalization; model; patients; prediction; risk; variables cache: cord-353200-5csewb1k.txt plain text: cord-353200-5csewb1k.txt item: #2803 of 2876 id: cord-353228-fxrf5wsp author: Xiao, Yaru title: Clinical characteristics of diarrhea in 90 cases with COVID-19: a descriptive study date: 2020-08-08 words: 1643 flesch: 50 summary: It is worth noting that COVID-19 patients with mild to moderate liver injuries, including elevated aminotransferases and hypoproteinemia, have also been reported, and some of the patients had digestive system impairment 11 . Among the gastrointestinal symptoms in COVID-19 cases including diarrhea, nausea, vomiting, and abdominal pain, diarrhea is the one that possibly increases the chance of potential fecal-oral transmission but could be easily overlooked by health care workers. keywords: cases; covid-19; diarrhea; patients cache: cord-353228-fxrf5wsp.txt plain text: cord-353228-fxrf5wsp.txt item: #2804 of 2876 id: cord-353256-7nfklun9 author: Eroglu‐Ertugrul, Nesibe Gevher title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date: 2019-11-22 words: 3097 flesch: 31 summary: No serious complications because bronchoscopy have been detected in the juvenile age group among immunocompromised patients as found in our study and reported in the previous literature; 15, 17 however, this is not the case in adult patients with immune deficiency, who exhibited a higher incidence of serious complications. These results may be related to the protective effect of prophylactic antibiotics that had been administered since the beginning of the BMT process as well as the preparation regimens that cause T-cell depletion in order to prevent the occurrence of graft versus host disease, both of which may play a critical role in the increased frequency of the presence of viral and opportunistic agents in BMT patients. keywords: bal; findings; group; patients; treatment cache: cord-353256-7nfklun9.txt plain text: cord-353256-7nfklun9.txt item: #2805 of 2876 id: cord-353281-leb7c7b0 author: Spiezia, Luca title: COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure date: 2020-04-21 words: 1141 flesch: 35 summary: Interestingly enough, markedly hypercoagulable thromboelastometry profiles were observed in COVID-19 patients, as reflected by shorter Clot Formation Time (CFT) in INTEM ( p = 0.0002) and EXTEM ( p = 0.01) and higher Maximum Clot Firmness (MCF) in INTEM, EXTEM and FIBTEM ( p < 0.001 in all comparisons). In conclusion, COVID-19 patients with acute respiratory failure present a severe hypercoagulability rather than consumptive coagulopathy. keywords: covid-19; patients; profiles; study cache: cord-353281-leb7c7b0.txt plain text: cord-353281-leb7c7b0.txt item: #2806 of 2876 id: cord-353293-vjdwh19x author: None title: Post-COVID-19 global health strategies: the need for an interdisciplinary approach date: 2020-06-11 words: 3861 flesch: 32 summary: It therefore appears appropriate to propose a detailed model for the first assessment (minimum data set for the assessment of COVID-19 patients), providing that subsequent stages can be customized based on the initial findings ( Table 1) . Nothing is known about long-term respiratory sequelae in COVID-19 patients. keywords: assessment; care; covid-19; disease; infection; patients; phase; post; risk; sars cache: cord-353293-vjdwh19x.txt plain text: cord-353293-vjdwh19x.txt item: #2807 of 2876 id: cord-353340-l0icku0i author: Olaoye, Omotayo title: Improving Access to Antimicrobial Prescribing Guidelines in 4 African Countries: Development and Pilot Implementation of an App and Cross-Sectional Assessment of Attitudes and Behaviour Survey of Healthcare Workers and Patients date: 2020-08-29 words: 4941 flesch: 41 summary: The study also highlighted that, although designed for health professionals, around 15% of health apps are now marketed to patients to help them monitor, evaluate, and transmit medical data such as blood pressure and body weight among other health checks [9] . Pharmacists were seen to refer to their senior colleagues for antibiotic information more than doctors, nurses and other health professionals. keywords: app; guidelines; health; healthcare; mobile; patients; professionals; use; workers cache: cord-353340-l0icku0i.txt plain text: cord-353340-l0icku0i.txt item: #2808 of 2876 id: cord-353375-92pu0pp0 author: Hung, Jennifer C. H. title: Implications of COVID-19 for uveitis patients: perspectives from Hong Kong date: 2020-04-29 words: 1008 flesch: 35 summary: key: cord-353375-92pu0pp0 authors: Hung, Jennifer C. H.; Li, Kenneth K. W. title: Implications of COVID-19 for uveitis patients: perspectives from Hong Kong date: 2020-04-29 journal: Eye (Lond) DOI: 10.1038/s41433-020-0905-1 sha: doc_id: 353375 cord_uid: 92pu0pp0 nan In December 2019, a novel coronavirus caused an outbreak of viral pneumonia in Wuhan, China. In addition, uveitis patients on active treatment often require frequent outpatient visits to assess their disease progression and to titrate their treatment. keywords: cases; patients; uveitis cache: cord-353375-92pu0pp0.txt plain text: cord-353375-92pu0pp0.txt item: #2809 of 2876 id: cord-353401-y1mxnth7 author: Williams, Roger D. title: Moral Injury in Times of COVID-19 date: 2020-05-02 words: 3542 flesch: 44 summary: A rational model for allocating health care resources is imperative. Health care systems that employ a proactive approach in mitigating the lasting effects of moral distress will fare better in the long run. keywords: allocation; care; covid-19; crisis; distress; health; pandemic; patients; psychologists; resource cache: cord-353401-y1mxnth7.txt plain text: cord-353401-y1mxnth7.txt item: #2810 of 2876 id: cord-353484-q7d0ysbo author: Liu, Xue title: COVID-19: Progress in diagnostics, therapy and vaccination date: 2020-06-19 words: 8584 flesch: 33 summary: medRxiv Coronaviruses -drug discovery and therapeutic options Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro First Case of 2019 Novel Coronavirus in the United States Compassionate Use of Remdesivir for Patients with Severe Covid-19 Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial Effects of chloroquine on viral infections: an old drug against today's diseases? Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Treating COVID-19 with Chloroquine Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC) Experimental drugs poised for use in Ebola outbreak Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir Chloroquine is a potent inhibitor of SARS coronavirus infection and spread SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and Other Drugs for the Treatment of the New Coronavirus Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study. Revised 18 Engineering DNA vaccines against infectious diseases Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial Immunogenicity of a DNA vaccine candidate for COVID-19 Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques Safety of trivalent inactivated influenza vaccines in adults: background for pandemic influenza vaccine safety monitoring Inactivated poliovirus vaccine: past and present experience Safety and Immunogenicity Study of Inactivated Vaccine for Prophylaxis of SARS CoV-2 Infection (COVID-19) Novavax Initiates Phase 1/2 Clinical Trial of COVID-19 Vaccine. keywords: antibodies; antibody; coronavirus; cov-2; covid-19; detection; disease; human; infection; novel; patients; protein; receptor; sars; specific; treatment; trial; vaccines cache: cord-353484-q7d0ysbo.txt plain text: cord-353484-q7d0ysbo.txt item: #2811 of 2876 id: cord-353594-z1vxamvp author: Gagiannis, Daniel title: Clinical, Serological, and Histopathological Similarities Between Severe COVID-19 and Acute Exacerbation of Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD) date: 2020-10-02 words: 5017 flesch: 34 summary: ANA titers ≥1:320 and/or positive ENA immunoblots were detected in 11/13 (84.6%) COVID-19 patients with ARDS, in 1/9 (11.1%) COVID-19 patients without ARDS (p = 0.002) and in 4/10 (40%) patients with non-COVID-19-associated pneumonias (p = 0.039). Our findings indicate that autoimmune mechanisms determine both clinical course and long-term sequelae after SARS-CoV-2 infection, and the presence of autoantibodies might predict adverse clinical course in COVID-19 patients. keywords: ana; anti; ards; autoantibodies; cases; cov-2; covid-19; disease; lung; patients; pneumonia; sars; table cache: cord-353594-z1vxamvp.txt plain text: cord-353594-z1vxamvp.txt item: #2812 of 2876 id: cord-353599-cw29edwr author: Kelleni, Mina T. title: Early use of Non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes date: 2020-11-04 words: 2617 flesch: 22 summary: In this manuscript, we present a novel theory to explain the pathogenesis of COVID-19; lymphocyte distraction theory upon which the author has used, in a preprinted protocol, non-steroidal anti-inflammatory drugs (NSAIDs); diclofenac potassium, ibuprofen and ketoprofen, successfully to treat COVID-19 patients. Furthermore, we agree with a recommendation that glucocorticoids should not be used routinely for COVID-19 patients and suggested to be beneficial only for patients with late acute respiratory distress syndrome. keywords: covid-19; ibuprofen; lymphopenia; patients; sars cache: cord-353599-cw29edwr.txt plain text: cord-353599-cw29edwr.txt item: #2813 of 2876 id: cord-353648-rl9dts7l author: Kim, Hyun Joo title: Guidelines for the control and prevention of coronavirus disease (COVID-19) transmission in surgical and anesthetic settings date: 2020-05-12 words: 1554 flesch: 44 summary: mid= a20507020000&bid= 0019 &act= view&list_no= 366579 FAQ on anesthesia machine use, protection, and decontamination during the COVID-19 pandemic No potential conflict of interest relevant to this article was reported. ③ Draeger • Refer to the link and attached file for the protocols to disassemble, clean, disinfect, and reassemble different types of anesthesia machine (Attachment 4. keywords: anesthesia; cleaning; filter; patient cache: cord-353648-rl9dts7l.txt plain text: cord-353648-rl9dts7l.txt item: #2814 of 2876 id: cord-353671-xjpzhsup author: Sgouros, George title: Radiopharmaceutical therapy in cancer: clinical advances and challenges date: 2020-07-29 words: 15007 flesch: 27 summary: xxxx Estimation of clinical trial success rates and related parameters Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials Targeted radionuclide therapy in combined-modality regimens Radioactive drugs emerge from the shadows to storm the market Radiosynovectomy in the therapeutic management of arthritis Local Treatment of Inflammatory Joint Diseases: Benefits and Risks Quantitative analyses of normal tissue effects in the clinic (QUANTEC): an introduction to the scientific issues The radiobiology of conventional radiotherapy and its application to radionuclide therapy Methodology to incorporate biologically effective dose and equivalent uniform dose in patient-specific 3-dimensional dosimetry for non Radiobiological aspects of low-dose rates in radioimmunotherapy Radiobiological treatment of RPT Radioimmunotherapy with alpha-emitting nuclides Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies Therapeutic applications of Auger and alpha emitting radionuclides Relationships between tumor size and curability for uniformly targeted therapy with beta-emitting radionuclides Therapeutic advantages of Auger electron-over beta-emitting radiometals or radioiodine when conjugated to internalizing antibodies Radionuclide therapy with iodine-125 and other Auger-electron-emitting radionuclides: experimental models and clinical applications Biophysical Aspects of Auger Processes Radiolabeled nucleoside analogs in cancer diagnosis and therapy Auger radiopharmaceutical therapy targeting prostate-specific membrane antigen Pilot clinical trial of 5-[ 125 I]iodo-2'-deoxyuridine in the treatment of colorectal cancer metastatic to the liver Pharmacokinetics and dosimetry of iodine-125-IUdR in the treatment of colorectal cancer metastatic to liver Mathematical model of 5-[ 125 I] iodo-2'-deoxyuridine treatment: continuous infusion regimens for hepatic metastases First human treatment of resistant neoplastic meningitis by intrathecal administration of MTX plus 125 IUdR Therapeutic efficacy and dose-limiting toxicity of Auger-electron vs. beta emitters in radioimmunotherapy with internalizing antibodies: evaluation of 125 I-vs. 131 I-labeled CO17-1A in a human colorectal cancer model Auger electrons for cancer therapy -a review Metal complexes of bleomycin: evaluation of [Rh-105]-bleomycin for use in targeted radiotherapy Therapeutic efficacy of a 188 Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models Comparison between three promising ß-emitting radionuclides 47 Sc and 161 Tb, with emphasis on doses delivered to minimal residual disease Application of the linear-quadratic model to radioimmunotherapy: further support for the advantage of longer-lived radionuclides A model of the peritoneal cavity for use in internal dosimetry Why are investors not interested in my radiotracer? Prospects for imaging and therapy Review of therapeutic applications of radiolabeled functional nanomaterials Antibody-targeted liposomes in cancer therapy and imaging Radioembolization for the treatment of primary and metastatic liver cancers Arming antibodies: prospects and challenges for immunoconjugates Minibody: a novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-C H 3) which exhibits rapid, high-level targeting of xenografts Tumor localization of anti-CEA single-chain Fvs: improved targeting by non-covalent dimers Single-chain Fv-streptavidin substantially improved therapeutic index in multistep targeting directed at disialoganglioside GD2 Pretargeting of renal cell carcinoma: improved tumor targeting with a bivalent chelate Molecular advances in pretargeting radioimunotherapy with bispecific antibodies Bispecific antibody pretargeting PET (ImmunoPET) with an I-124-labeled haptenpeptide Treatment of cancer of the thyroid postoperatively with suppressive thyroid medication, radioactive iodine, and thyroid-stimulating hormone Studies in iodine metabolism of the thyroid gland in situ by the use of radio-iodine in normal subjects and in patients with various types of goiter Relation of radioiodine dosimetry to results and complications in treatment of metastatic thyroid cancer Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer Radioactive iodine isotopes Radiopharmaceuticals for Therapy -2016 Radioactive iodine as an indicator in thyroid physiology -Iodine collection by normal and hyperplastic thyroids in rabbits Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer Biologic and clinical perspectives on thyroid cancer Internal radiotherapy using 32 P colloid or microsphere for refractory solid tumors Radium-223 mechanism of action: implications for use in treatment combinations Dose-dependent growth delay of breast cancer xenografts in the bone marrow of mice treated with 223 Ra: the role of bystander effects and their potential for therapy Decreased fracture rate by mandating bone-protecting agents in the EORTC 1333/PEACE III trial comparing enzalutamide and Ra223 versus enzalutamide alone: an interim safety analysis ERA 223: a phase 3 trial of radium-223 dichloride (Ra-223) in combination with abiraterone acetate (abiraterone) and prednisone in the treatment of asymptomatic or mildly symptomatic chemotherapy-naïve patients (pts) with bone predominant metastatic castration-resistant prostate cancer (mCRPC) Higher risk of fragility fractures in prostate cancer patients treated with combined radium-223 and abiraterone: prednisone may be the culprit Overview of samarium Sm 153 lexidronam in the treatment of painful metastatic bone disease Current Advances in Osteosarcoma Samarium-153-ethylene diamine tetramethylene phosphonate, a beta-emitting bone-targeted radiopharmaceutical, useful for patients with osteoblastic bone metastases Sm-EDTMP on calcium hydroxyapatite Samarium-153-EDTMP biodistribution and dosimetry estimation Bone-targeting radiopharmaceuticals for the treatment of prostate cancer with bone metastases Preclinical evaluation of Sm-153-DOTMP as a therapeutic bone-seeking radiopharmaceutical A preclinical investigation of the saturation and dosimetry of 153 Sm-DOTMP as a bone-seeking radiopharmaceutical I-131-mIBG therapy in neuroblastoma: established role and prospective applications keywords: 131; agents; alpha; antibodies; antibody; bone; cancer; cells; delivery; dose; dosimetry; efficacy; imaging; metastatic; particle; patients; phase; prostate; psma; radiation; radionuclide; rpt; study; targeted; targeting; therapeutic; therapy; treatment; trial; tumour cache: cord-353671-xjpzhsup.txt plain text: cord-353671-xjpzhsup.txt item: #2815 of 2876 id: cord-353697-ocxextfj author: Santana, Monique Freire title: Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management date: 2020-07-03 words: 1891 flesch: 35 summary: COVID-19 is characterized by asymptomatic and/or mild flulike symptoms; however, about 20% of patients may progress to pneumonia and sepsis, thus requiring intensive support 1, . Patients with acute respiratory distress syndrome due to viral infections, such as SARS-CoV-2, are prone to secondary complications, including aspergillosis 2 . keywords: aspergillosis; aspergillus; covid-19; disease; infection; ipa; patient cache: cord-353697-ocxextfj.txt plain text: cord-353697-ocxextfj.txt item: #2816 of 2876 id: cord-353698-gj8sx3zy author: Bibiano-Guillen, C. title: Adapted Diving Mask (ADM) device as respiratory support with oxygen output during COVID-19 pandemic date: 2020-10-28 words: 3323 flesch: 47 summary: This prevents exposure to other patients and healthcare professionals [29, 32, 33] . To assess patient improvement, we used the following variables: The medical records of patients were analyzed by the research team of the Emergency Department, Hospital Universitario Infanta Leonor, Madrid. keywords: adm; covid-19; mask; oxygen; patients; saturation; support; use cache: cord-353698-gj8sx3zy.txt plain text: cord-353698-gj8sx3zy.txt item: #2817 of 2876 id: cord-353786-284qn075 author: Chen, Zhi-Min title: Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus date: 2020-02-05 words: 3552 flesch: 43 summary: Following latest National recommendations for diagnosis and treatment of respiratory infections caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted out by the National Clinical Research Center for Child Health, National Children's Regional Medical Center, Children's Hospital, Zhejiang University School of Medicine to further standardize the protocol of respiratory infection in children caused by 2019-nCoV. Etiology 2019-nCoV is a novel human coronavirus in addition to coronavirus 229E, NL63, OC43, HKU1, Middle East respiratory syndrome-related coronavirus (MERSr-CoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV). Access 29 Clinical features of patients infected with 2019 novel coronavirus in Wuhan Another decade, another coronavirus Diangosis and treatment guideline of community acquired pneumonia in children Role of Lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Expert consensus on the diagnosis and treatment of viral pneumonia in children Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected The Editorial Board, Chinese Journal of Pediatrics. keywords: blood; cases; children; coronavirus; diagnosis; infection; ncov; patients; pneumonia; treatment cache: cord-353786-284qn075.txt plain text: cord-353786-284qn075.txt item: #2818 of 2876 id: cord-353824-0oyvia6d author: Farooque, Umar title: Coronavirus Disease 2019-Related Acute Ischemic Stroke: A Case Report date: 2020-09-08 words: 1880 flesch: 48 summary: The possibility as to whether anticoagulant or antiplatelet agents may be superior in stroke patients with COVID-19 requires further consideration. Negative pressure carrier isolators can be used to isolate COVID-19 patients during neurovascular imaging. keywords: acute; covid-19; infection; patients; risk; stroke cache: cord-353824-0oyvia6d.txt plain text: cord-353824-0oyvia6d.txt item: #2819 of 2876 id: cord-353956-gjv5cg3k author: Bali, Rishi Kumar title: Maxillofacial surgery and COVID-19, The Pandemic !! date: 2020-04-11 words: 1136 flesch: 43 summary: The collection, segregation, and transport of infectious waste from COVID-19 patients should be done under the guidance of the Infection Control/ Biomedical Waste Management Officer of the institute. As with most respiratory infections, droplets are the main source of transmission from COVID-19 patients. keywords: covid-19; infection; patients; use cache: cord-353956-gjv5cg3k.txt plain text: cord-353956-gjv5cg3k.txt item: #2820 of 2876 id: cord-353987-hj94a04i author: Lehmann, L. H. title: Establishing an oncocardiology service date: 2020-06-22 words: 3134 flesch: 26 summary: Besides establishing surveillance and follow-up strategies for cancer patients, it will be essential to set up specialized oncocardiology services. However, there is a lack of clinical studies to give evidence-based recommendations regarding cardiological diagnostic and therapeutic approaches for cancer patients. keywords: cancer; cardiac; oncocardiology; oncology; patients; service; society cache: cord-353987-hj94a04i.txt plain text: cord-353987-hj94a04i.txt item: #2821 of 2876 id: cord-354103-4dldgqzf author: Grubic, Andrew D title: COVID-19 outbreak and surgical practice: The rationale for suspending non-urgent surgeries and role of testing modalities date: 2020-06-27 words: 4875 flesch: 44 summary: ACE2 receptors are also located in the enterocytes of the small intestine which is considered to be an explanation for digestive symptoms in COVID-19 patients [13, 14] . Several studies have highlighted the presence of virus in the feces of COVID-19 patients, and now fecal-oral transmission has also been proposed as a mechanism of spread [8, 9] , which may profoundly impact underdeveloped countries. keywords: care; cases; coronavirus; cov-2; covid-19; disease; pandemic; patients; pcr; sars; transmission cache: cord-354103-4dldgqzf.txt plain text: cord-354103-4dldgqzf.txt item: #2822 of 2876 id: cord-354127-sb8tovy2 author: de Abreu, Andrea Pio title: Recommendations from the Brazilian Society of Nephrology regarding the use of cloth face coverings, by chronic kidney patients in dialysis, during the new coronavirus pandemic (Covid-19) date: 2020-08-26 words: 1350 flesch: 49 summary: Taking into account the necessary prioritization of the provision of Personal Protective Equipment (PPE) for patients with suspected or confirmed disease, as well as for healthcare professionals, the SBN is favorable concerning the wear of cloth masks by chronic kidney patients in dialysis, in public settings, except in the dialysis setting. Taking into account the necessary prioritization of the provision of Personal Protective Equipment (PPE) for patients with suspected or confirmed disease, as well as for healthcare professionals, the SBN is favorable concerning the wear of cloth masks by chronic kidney patients in dialysis, in public settings, except in the dialysis setting. keywords: cloth; mask; patients; recommendations cache: cord-354127-sb8tovy2.txt plain text: cord-354127-sb8tovy2.txt item: #2823 of 2876 id: cord-354160-sca9bgeq author: Al-Tawfiq, Jaffar A. title: Changes in Healthcare managing COVID and non-COVID-19 patients during the pandemic: Striking the balance date: 2020-08-13 words: 1749 flesch: 38 summary: There are multiple factors contributing to the apparent reduced utilization of healthcare services by to non-COVID-19 patients. Furthermore, in order to properly care for non-COVID-19 patients, it had been suggested that there should be separate hospitals for those with COVID-19 and those without COVID- 19 keywords: covid-19; healthcare; non; pandemic; patients cache: cord-354160-sca9bgeq.txt plain text: cord-354160-sca9bgeq.txt item: #2824 of 2876 id: cord-354168-omen8vvq author: Al Saleh, Abdullah S. title: Multiple Myeloma in the Time of COVID-19 date: 2020-04-17 words: 3955 flesch: 52 summary: key: cord-354168-omen8vvq authors: Al Saleh, Abdullah S.; Sher, Taimur; Gertz, Morie A. title: Multiple Myeloma in the Time of COVID-19 date: 2020-04-17 journal: Acta Haematol DOI: 10.1159/000507690 sha: doc_id: 354168 cord_uid: omen8vvq We provide our recommendations (not evidence based) for managing multiple myeloma patients during the pandemic of COVID-19. Lancet Oncol Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients Nadir lymphocytopenia as a risk factor of bloodstream infection during molecular targeting pharmacotherapy in multiple myeloma Pretreatment lymphopenia, poor performance status, and early courses of therapy are risk factors for severe bacterial infection in patients with multiple myeloma during treatment with bortezomib-based regimens Lymphocytopenia is associated with an increased risk of severe infections in patients with multiple myeloma treated with bortezomib-based regimens Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections Low frequency of CD3+CD4+CD161+ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment Infection risk with immunomodulatory and proteasome inhibitor-based therapies across treatment phases for multiple myeloma: a systematic review and meta-analysis Decrease in CD4+ T-cell counts in patients with multiple myeloma treated with bortezomib Analysis of herpes zoster events among bortezomib-treated patients in the phase III APEX study Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial Clinical features of patients infected with 2019 novel coronavirus in Wuhan Risk stratification of smoldering multiple myeloma incorporating revised IMWG diagnostic criteria Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma Randomized trial of lenalidomide versus observation in smoldering multiple myeloma Revised international staging system for multiple myeloma: a report from International Myeloma Working Group get-your-household-ready-for-COVID-19.html?CDC_AA_ r e f V a l keywords: asct; covid-19; dexamethasone; lenalidomide; myeloma; patients; risk; therapy cache: cord-354168-omen8vvq.txt plain text: cord-354168-omen8vvq.txt item: #2825 of 2876 id: cord-354194-hf5ndv5f author: Cook, Mackenzie title: Prioritizing Communication in the Provision of Palliative Care for the Trauma Patient date: 2020-10-29 words: 7936 flesch: 38 summary: We are strangers walking into their life-changing event: how prehospital providers manage emergency calls at the end of life Missed opportunities: integrating palliative care into the emergency department for older adults presenting as level I triage priority from long-term care facilities Preadmission Do Not Resuscitate advanced directive is associated with adverse outcomes following acute traumatic injury Experiences with POLST: opportunities for improving advance care planning: Editorial & Comment on Association between physician orders for life-sustaining treatment for scope of treatment and in-hospital death in Oregon Injured older adults transported by emergency medical services: one year outcomes by POLST status Physician orders for life-sustaining treatment (POLST): lessons learned from analysis of the Oregon POLST Registry Lessons from Oregon in Embracing Complexity in End-of-Life Care A comparison of methods to communicate treatment preferences in nursing facilities: traditional practices versus the physician orders for life-sustaining treatment program Family presence during resuscitation after trauma Family presence during trauma resuscitation: ready for primetime? Effects of family-witnessed resuscitation after trauma prior to hospitalization Experiences of families when present during resuscitation in the emergency department after trauma Family presence during trauma resuscitation: family members' attitudes, behaviors, and experiences Family presence during cardiopulmonary resuscitation 153-60 Propensitymatched study showing that POLST forms available in the early phases of trauma care do indeed alter the management of patients and that, when specified Palliative care interventions for surgical patients: a systematic review Structure and function of a trauma intensive care unit: a report from the Trauma Intensive Care Unit Prevalence Project A structured approach to supporting communciation with families in the ICU can improve family perceptions of the patient and family centeredness of the care as well as reduce hospital length of stay Effect of palliative care-led meetings for families of patients with chronic critical illness: a randomized clinical trial Identifying patients in need of a palliative care assessment in the hospital setting: a consensus report from the Center to Advance Palliative Care 1173-5 An outline of the model of palliative care that may be the most successful-primary palliative care from the ICU team with subspecialty consultation The costs of waiting: implications of the timing of palliative care consultation among a cohort of decedents at a comprehensive cancer center To operate or not to operate? Primary palliative care (PPC) is defined as palliative care provided by the primary treating service. keywords: care; communication; decision; end; family; goals; icu; injury; life; palliative; patients; team; trauma cache: cord-354194-hf5ndv5f.txt plain text: cord-354194-hf5ndv5f.txt item: #2826 of 2876 id: cord-354204-23xkug85 author: Smargiassi, Andrea title: Lung ultrasonography for early management of patients with respiratory symptoms during COVID-19 pandemic date: 2020-07-07 words: 3445 flesch: 29 summary: A proposed algorithm to early manage pediatric patients with symptoms compatible with COVID-19, admitted to the pediatric emergency room Zhang J (2020) Characteristics of COVID-19 infection in Beijing Clinical progression of patients with COVID-19 in Shanghai Clinical features of patients infected with novel 2019 coronavirus in Wuhan CT features of SARS-CoV-2 pneumonia according to clinical presentation: a retrospective analysis of 120 consecutive patients from Wuhan city Chinese Critical Care Ultrasound Study Group (CCUSG) (2020) Findings of lung ultrasonography of novel corona virus pneumonia during the 2019-2020 epidemic Is there a role for lung ultrasound during the COVID-19 outbreak? Pulmonary pathology of early-phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer COVID-19: pneumonia, ARDS or something else? Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis The role of ultrasound lung artifacts in the diagnosis of respiratory diseases Lung ultrasonography and vertical artifacts: the shape of air Artifactual lung ultrasonography: it is a matter of traps, order, and disorder On the physical basis of pulmonary sonographic interstitial syndrome Lung ultrasonography may provide an indirect estimation of lung porosity and airspace geometry Physical mechanisms providing clinical information from ultrasound lung images: hypotheses and early confirmations Determination of a potential quantitative measure of the state of the lung using lung ultrasound spectroscopy Proposal for international standardization of the use of lung ultrasound for COVID-19 patients; a simple, quantitative, reproducible method Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents Chest sonography: a useful tool to differentiate acute cardiogenic pulmonary edema from acute respiratory distress syndrome Thoracic ultrasound and SARS-COVID-19: a pictorial essay How to perform lung ultrasound in pregnant women with suspected COVID-19 infection Effectiveness of a 'fast lung ultrasound teaching program' for gynecologists/obstetricians dealing with pregnant women with suspicion of COVID-19 infection Clinical role of lung ultrasound for the diagnosis and monitoring of COVID-19 pneumonia in pregnant women The diagnosis of pneumonia in a pregnant woman with covid-19 using maternal lung ultrasound Acute respiratory distress syndrome in pregnancy Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak Is lung ultrasound useful for diagnosing pneumonia in children? In our experience in performing LUS in suspected COVID-19 patients, both pocket and wireless devices [17] than standard ultrasound machines can be used better if dedicated exclusively to COVID-19 patients to reduce healthcare operator/patients infection. keywords: covid-19; lung; lus; patients; pneumonia; tests cache: cord-354204-23xkug85.txt plain text: cord-354204-23xkug85.txt item: #2827 of 2876 id: cord-354216-4khdcjed author: Sultan, Shahnaz title: AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19 date: 2020-05-11 words: 5643 flesch: 38 summary: Therefore, in high prevalence settings, among patients presenting with new onset diarrhea, monitoring for the development of COVID-19 symptoms and considering referring patients for COVIDtesting is reasonable especially if testing capacity is not limited. In a handful of studies, diarrhea and nausea preceded the development of other COVID-19 related symptoms. keywords: analysis; clinical; coronavirus; covid-19; data; diarrhea; disease; liver; patients; studies; symptoms cache: cord-354216-4khdcjed.txt plain text: cord-354216-4khdcjed.txt item: #2828 of 2876 id: cord-354223-0ckpz0bx author: Yu, Pengming title: Early Rehabilitation for Critically Ill Patients With COVID-19: More Benefits Than Risks date: 2020-04-13 words: 1664 flesch: 31 summary: The rehabilitation clinicians are concerned that there is no precedent for early rehabilitation treatment of COVID-19, a lack of experience in acute management of COVID-19 patients, and the absence of guidelines, recommendations, and expert consensus. The finding suggests that COVID-19 patients commonly had neurological symptoms manifested as acute stroke (6%), consciousness impairment (15%), and skeletal muscle injury (19%). keywords: covid-19; disease; patients; rehabilitation cache: cord-354223-0ckpz0bx.txt plain text: cord-354223-0ckpz0bx.txt item: #2829 of 2876 id: cord-354337-a70avg2x author: Mehraeen, Esmaeil title: A systematic review of ECG findings in patients with COVID-19 date: 2020-11-13 words: 3151 flesch: 46 summary: Drug induced QT prolongation and torsades de pointes In-hospital cardiac arrest outcomes among patients with COVID-19 pneumonia in Wuhan Cardiac Involvement in a Patient with Coronavirus Disease 2019 (COVID-19) ST-Segment Elevation in Patients with Covid-19 -A Case Series. The other four studies administered both monotherapy (chloroquine/hydroxychloroquine) and combination treatmentfor COVID-19 patients and confirmed that combination therapy is associated with a higher risk of QTc interval prolongation compared with monotherapy (18) (19) (20) (21) . keywords: cardiac; case; changes; covid-19; ecg; patients; qtc; studies cache: cord-354337-a70avg2x.txt plain text: cord-354337-a70avg2x.txt item: #2830 of 2876 id: cord-354372-vfvnjmv1 author: Carpenito, L. title: The autopsy at the time of SARS-CoV-2: Protocol and lessons date: 2020-07-04 words: 5697 flesch: 46 summary: Immunohistochemistry, like biomolecular investigations performed on autopsy tissue samples, allows also to detect the presence of the SARS-CoV-2 in the body, detailing its distribution in single cell types ( fig. In addition, immunohistochemical tests on autopsy samples taken within 1-2 hours from death are more reliable, which is particularly important when these tests are used to describe a new pathologic entity such as COVID-19 ( fig. 3) . keywords: autopsies; autopsy; blood; body; cov-2; death; evisceration; examination; patients; room; samples; sars cache: cord-354372-vfvnjmv1.txt plain text: cord-354372-vfvnjmv1.txt item: #2831 of 2876 id: cord-354373-lldfoptb author: Chi, Jeffrey title: COVID-19 Clinical Research date: 2020-05-05 words: 2495 flesch: 45 summary: At the present time, cancer patients are eligible for the vast majority of COVID-19 clinical trials regardless of cancer directed treatment status. In a recent open-label, non-randomized trial, Gautret et al. showed significant reduction in viral load in COVID-19 patients treated with hydroxychloroquine [8] . keywords: coronavirus; cov-2; covid-19; patients; phase; sars; treatment; trials cache: cord-354373-lldfoptb.txt plain text: cord-354373-lldfoptb.txt item: #2832 of 2876 id: cord-354411-4emzxu09 author: Nouvenne, Antonio title: Lung Ultrasound in COVID-19 Pneumonia: Correlations with Chest CT on Hospital admission date: 2020-06-22 words: 3970 flesch: 37 summary: METHODS: Twenty-six patients (14 males, age 64 ± 16 years) urgently hospitalized for COVID-19 pneumonia, who underwent chest CT and bedside LUS on the day of admission, were enrolled in this observational study. The sensitivity of CT for diagnosing COVID-19 pneumonia is 97% considering the results of reverse-transcription polymerase-chain reaction (RT-PCR) tests as gold standard [2] . keywords: chest; covid-19; findings; lung; lus; patients; pneumonia; score; ultrasound cache: cord-354411-4emzxu09.txt plain text: cord-354411-4emzxu09.txt item: #2833 of 2876 id: cord-354597-xubsodnk author: Carvalho, Alexandre title: SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease date: 2020-04-17 words: 2785 flesch: 39 summary: A novel coronavirus from patients with pneumonia in China Coronavirus Disease Testing (COVID-19): Symptoms & Testing Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: A descriptive, cross-sectional, multicenter study Evidence for gastrointestinal infection of SARS-Cov-2 COVID-19 disease with positive fecal and negative pharyngeal and sputum viral tests Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China ACG clinical practice guideline: Diagnosis, treatment, and prevention of acute diarrheal infections in adults Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection Angiotensinconverting enzyme 2 is a functional receptor for the SARS coronavirus Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. Awareness of the gastrointestinal manifestations of SARS-CoV-2 may have increased our index of suspicion and encouraged us to institute SARS-CoV-2 precautions on arrival, avoiding the exposure and subsequent quarantine of 72 healthcare workers, including many of us. keywords: cov-2; data; day; disease; infection; patient; sars; symptoms cache: cord-354597-xubsodnk.txt plain text: cord-354597-xubsodnk.txt item: #2834 of 2876 id: cord-354619-pftjhtpo author: Farronato, Marco title: A Call for Action to Safely Deliver Oral Health Care during and Post COVID-19 Pandemic date: 2020-09-15 words: 5048 flesch: 42 summary: A first step in understanding SARS pathogenesis Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3 Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2 Multifaceted roles for lipids in viral infection Regulation of raft-dependent endocytosis PEDV enters cells through clathrin-, caveolae-, and lipid raftmediated endocytosis and traffics via the endo-/lysosome pathway Cholesterol Enhances Mouse Hepatitis Virus-Mediated Cell Fusion Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: A possible strategy for reducing SARS-COV-2 infectivity? Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 Clinical characteristics of coronavirus disease 2019 in China Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents Characterization of Pathogenic Bacteria Isolated from Sudanese Banknotes and Determination of Their Resistance Profile Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis Clinical and demographic characteristics of patients dying from COVID-19 in Italy versus China COVID-19 Lombardy ICU Network. The main limitation of these recommendations is represented from COVID-19 asymptomatic patients (negative to triage) that are not at the moment correctly identified. keywords: ace2; consultations; cov-2; covid-19; dental; dhcw; evidence; health; infection; patients; sars; transmission cache: cord-354619-pftjhtpo.txt plain text: cord-354619-pftjhtpo.txt item: #2835 of 2876 id: cord-354658-v451z3jq author: Rajagopal, Keshava title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 words: 8894 flesch: 36 summary: The ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure describes usage of ECMO in COVID-19 patients intended for experienced ECMO centers. key: cord-354658-v451z3jq authors: Rajagopal, Keshava; Keller, Steven P.; Akkanti, Bindu; Bime, Christian; Loyalka, Pranav; Cheema, Faisal H.; Zwischenberger, Joseph B.; El Banayosy, Aly; Pappalardo, Federico; Slaughter, Mark S.; Slepian, Marvin J. title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 journal: ASAIO J DOI: 10.1097/mat.0000000000001180 sha: doc_id: 354658 cord_uid: v451z3jq The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. keywords: acute; arterial; cannulation; coronavirus; covid-19; disease; ecmo; failure; flow; infection; lung; patients; pressure; sars; setting; shock; support cache: cord-354658-v451z3jq.txt plain text: cord-354658-v451z3jq.txt item: #2836 of 2876 id: cord-354689-dsv63it1 author: Chen, Qian title: Precautionary Measures: Performing ERCP on a Patient With Juxtapapillary Duodenal Diverticula (JPDD)-Related Biliary Stone After COVID-19 Lockdown Restriction Lifted in Wuhan, China date: 2020-09-04 words: 3543 flesch: 34 summary: Based on our experiences, the objective is to provide practical suggestions for the safe resumption of ERCP procedures in the setting of the COVID-19 pandemic with specific focus on patient risk assessment, personal protection equipment (PPE), and dress code modalities, all of which have been implemented in our hospital to reduce the risk of viral transmission. The vital parameters [heart rate (HR), blood pressure (BP), FIGURE 1 | Patient management and risk assessment and detailed workflow during ERCP procedure. keywords: acute; covid-19; endoscopy; ercp; pancreatitis; patient; procedure; risk cache: cord-354689-dsv63it1.txt plain text: cord-354689-dsv63it1.txt item: #2837 of 2876 id: cord-354720-fu19u2b0 author: White-Dzuro, Gabrielle title: Multisystem effects of COVID-19: a concise review for practitioners date: 2020-11-04 words: 5093 flesch: 29 summary: Is the prone position helpful during spontaneous breathing in patients with COVID-19? In-hospital airway management of COVID-19 patients Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study High-volume hemofiltration for septic acute kidney injury: a systematic review and meta-analysis Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Incidence of thrombotic complications in critically ill ICU patients with COVID-19 Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations Neurologic manifestations of hospitalized patients with Coronavirus Disease Guillain-Barré Syndrome Associated with SARS-CoV-2 Central nervous system manifestations of COVID-19: a systematic review Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways Central nervous system involvement by severe acute respiratory syndrome Coronavirus −2 (SARS-CoV-2) Post mortem findings in COVID-19 patients show viral elements within endothelial cells, an accumulation of inflammatory cells, and cellular apoptosis in multiple organs [6] . keywords: acute; coronavirus; cov-2; covid-19; disease; effects; infection; injury; patients; risk; sars cache: cord-354720-fu19u2b0.txt plain text: cord-354720-fu19u2b0.txt item: #2838 of 2876 id: cord-354749-zkgb16ae author: Chen, Gang title: Core principles for infection prevention in hemodialysis centers during the COVID-19 pandemic date: 2020-04-06 words: 774 flesch: 40 summary: In a general tertiary-care hospital, dialysis centers routinely accept patients from outpatient clinics and emergency rooms, further adding to the difficulty of preventing nosocomial infection. For patients referred from other departments in the hospital, we collect records of their contact history, temperature, and potential warning symptoms before admission. keywords: center; dialysis; patients cache: cord-354749-zkgb16ae.txt plain text: cord-354749-zkgb16ae.txt item: #2839 of 2876 id: cord-354824-7fdcu2f0 author: Wu, Renyi title: An Update on Current Therapeutic Drugs Treating COVID-19 date: 2020-05-11 words: 9676 flesch: 38 summary: Chinese Clinical Trial Registry Why tocilizumab could be an effective treatment for severe COVID-19? Evaluation of the efficacy and safety of sarilumab in hospitalized patients with COVID-19 Overview of the IL-1 family in innate inflammation and acquired immunity Personalised immunotherapy for SARS-CoV-2 (COVID-19) associated with organ dysfunction Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Clinical characteristics of coronavirus disease 2019 in China Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus Genetic associations between genes in the renin-angiotensinaldosterone system and renal disease: a systematic review and meta-analysis Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensinconverting enzyme 2 A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19 Peroxisome proliferatoractivated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection Indomethacin has a potent antiviral activity against SARS coronavirus Colchicine-update on mechanisms of action and therapeutic uses Colchicine and the heart: pushing the envelope Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-coronavirus infection An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug The broad spectrum antiviral ivermectin targets the host nuclear transport importin alpha/beta1 heterodimer The FDAapproved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro A screen of the NIH clinical collection small molecule library identifies potential anti-coronavirus drugs Nitazoxanide, a new drug candidate for the treatment of Middle East respiratory syndrome coronavirus Meta-analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? Antibody-mediated regulation of cellular immunity and the inflammatory response Serum therapy revisited: animal models of infection and development of passive antibody therapy Fcmediated antibody effector functions during respiratory syncytial virus infection and disease A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus A serological survey on neutralizing antibody titer of SARS convalescent sera Use of convalescent plasma therapy in SARS patients in Hong Kong Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Deployment of convalescent plasma for the prevention and treatment of COVID-19 Treatment of 5 critically ill patients with COVID-19 with convalescent plasma Effectiveness of convalescent plasma therapy in severe COVID-19 patients Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 receptor binding domain The potential of low molecular weight heparin to mitigate cytokine storm in severe COVID-19 patients: a retrospective clinical study Redeploying plant defences Chinese herbal medicines for the treatment of type a H1N1 influenza: a systematic review of randomized controlled trials Clinical outcomes of influenza-like illness treated with Chinese herbal medicine: an observational study Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines Traditional Chinese medicine in the treatment of patients infected with 2019-new coronavirus (SARS-CoV-2): a review and perspective Investigating mechanism of Qingfei Dayuan granules for treatment of COVID-19 based on network pharmacology and molecular docking Study on screening potential traditional Chinese medicines against 2019-nCoV based on Mpro and PLP Chinese herbal medicine for severe acute respiratory syndrome: a systematic review and metaanalysis Traditional Chinese herbal medicine as a source of molecules with antiviral activity Can Chinese medicine be used for prevention of corona virus disease 2019 (COVID-19)? Evolving research and clinical data regarding the virologic SARS-CoV-2 suggest a potential list of repurposed drugs with appropriate pharmacological effects and therapeutic efficacies in treating COVID-19 patients. keywords: activity; antiviral; azithromycin; cells; clinical; coronavirus; cov-2; covid-19; disease; drugs; hydroxychloroquine; infection; influenza; lung; patients; rna; sars; study; syndrome; treatment; trial; viral cache: cord-354824-7fdcu2f0.txt plain text: cord-354824-7fdcu2f0.txt item: #2840 of 2876 id: cord-355003-1o2midnh author: Wang, Min title: Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report date: 2020-09-04 words: 1978 flesch: 51 summary: (H1N1) 2009 virus infection Use of convalescent plasma therapy in SARS patients in Hong Kong Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study Convalescent plasma: new evidence for an old therapeutic tool? Effectiveness of convalescent plasma therapy in severe COVID-19 patients Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience Medicine (2020) 99:36 www.md-journal Previous studies have shown that the convalescent plasma therapy (CPT) is effective in patients with COVID-19. keywords: covid-19; cpt; days; patients cache: cord-355003-1o2midnh.txt plain text: cord-355003-1o2midnh.txt item: #2841 of 2876 id: cord-355028-1x7w1749 author: Piazza, Cesare title: Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society date: 2020-06-06 words: 4323 flesch: 27 summary: key: cord-355028-1x7w1749 authors: Piazza, Cesare; Filauro, Marta; Dikkers, Frederik G.; Nouraei, S. A. Reza; Sandu, Kishore; Sittel, Christian; Amin, Milan R.; Campos, Guillermo; Eckel, Hans E.; Peretti, Giorgio title: Long-term intubation and high rate of tracheostomy in COVID-19 patients might determine an unprecedented increase of airway stenoses: a call to action from the European Laryngological Society date: 2020-06-06 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06112-6 sha: doc_id: 355028 cord_uid: 1x7w1749 INTRODUCTION: COVID-19 patients admitted to the ICU often require prolonged mechanical ventilation with high positive endexpiratory pressure through an endotracheal tube, with a frequency reported as high as 88% in a series of 1591 consecutive patients treated at 72 hospitals included in the COVID-19 Lombardy ICU Network, Italy keywords: airway; conditions; covid-19; endotracheal; icu; intubation; laryngotracheal; lts; patients; stenosis; tracheostomy cache: cord-355028-1x7w1749.txt plain text: cord-355028-1x7w1749.txt item: #2842 of 2876 id: cord-355031-l0tj7kp2 author: Krenitsky, Nicole M. title: Primed for a Pandemic: Implementation of Telehealth Outpatient Monitoring for Women with Mild COVID-19 date: 2020-07-21 words: 3004 flesch: 37 summary: key: cord-355031-l0tj7kp2 authors: Krenitsky, Nicole M.; Spiegelman, Jessica; Sutton, Desmond; Syeda, Sbaa; Moroz, Leslie title: Primed for a Pandemic: Implementation of Telehealth Outpatient Monitoring for Women with Mild COVID-19 date: 2020-07-21 journal: Semin Perinatol DOI: 10.1016/j.semperi.2020.151285 sha: doc_id: 355031 cord_uid: l0tj7kp2 Close observation and rapid escalation of care is essential for obstetric patients with COVID-19. We describe the experience and lessons learned while designing and implementing a virtual telemonitoring COVID-19 clinic for obstetric patients. keywords: care; clinic; covid-19; monitoring; patients; providers; telehealth; visits cache: cord-355031-l0tj7kp2.txt plain text: cord-355031-l0tj7kp2.txt item: #2843 of 2876 id: cord-355033-txxylmrw author: frontera, Jennifer A. title: Treatment with Zinc is Associated with Reduced In-Hospital Mortality Among COVID-19 Patients: A Multi-Center Cohort Study date: 2020-10-26 words: 4273 flesch: 37 summary: Several compounds have been identi ed as zinc ionophores including pyrithione(4), pyrrolidine dithiocarbamate(4), hinokitiol (8) , resveratrol (9) , plant polyphenols such as quercetin and epigallocatechin-gallate (10) , chloroquine and hydroxychloroquine (11) . However, to achieve adequate intracellular zinc levels, administration with an ionophore, which increases intracellular zinc levels, may be necessary. keywords: covid-19; hospital; ionophore; mortality; patients; score; study; treatment; zinc cache: cord-355033-txxylmrw.txt plain text: cord-355033-txxylmrw.txt item: #2844 of 2876 id: cord-355038-o2hr5mox author: None title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: 102622 flesch: 49 summary: No significant difference between the NE and AVP groups for lactate clearance between H0 and H6 (25.6 [− 7.31 to 35.34]% vs 47.84 [13.42-82.73 ]%, p = 0.686). D: blood frequency of MAIT cells in patients with pneumonia compared with healthy controls (as % of total T cells) keywords: 0.001; acute; admission; adult patients; age; aim; aki; analysis; antibiotic; ards; ards patients; association; blood; cardiac; care; care patients; care unit; cases; characteristics; children; cohort; compliance; complications; conclusion; conflict; control; data; days; death; diagnosis; disclosure; disease; duration; dysfunction; early; ecmo; end; ethics regulations; factors; failure; fig; following; france; group; high; hospital; hospital mortality; icu admission; icu mortality; icu patients; icu stay; impact; incidence; infection; influenza patients; injury; intensive; intensive care; interest; international; intubation; january; length; management; mean; median; medical; methods; model; months; mortality; mortality rate; multivariate; n =; national; niv; non; objective; outcome; p =; patients; period; pneumonia; post; pressure; prognosis; pulmonary; rate; rationale; respiratory; results; risk; score; sepsis; septic; severity; shock; sofa; stay; studies; study; study period; support; survival; syndrome; therapy; time; total; treatment; unit; use; ventilation; weaning; years cache: cord-355038-o2hr5mox.txt plain text: cord-355038-o2hr5mox.txt item: #2845 of 2876 id: cord-355039-qi4fwqbc author: Azar, William S. title: COVID-19 and diabetes mellitus: how one pandemic worsens the other date: 2020-08-02 words: 7376 flesch: 37 summary: A more favorable SARS-CoV-2 binding was demonstrated with increased ACE2 expression in alveolar AT2 cells, as well as in the myocardium, kidneys, and pancreas in humans The genome-wide association study (GWAS) on patients with type 2 diabetes (N = 898,130) revealed that type 2 diabetes is causally linked to increased ACE2 expression. keywords: ace2; ampk; angiotensin; coronavirus; cov-2; covid-19; cytokine; diabetes; disease; expression; il-6; infection; mtor; patients; protein; sars cache: cord-355039-qi4fwqbc.txt plain text: cord-355039-qi4fwqbc.txt item: #2846 of 2876 id: cord-355146-6rat5j64 author: Whittemore, Paul title: Use of awake proning to avoid invasive ventilation in a patient with severe COVID-19 pneumonitis date: 2020-08-03 words: 1335 flesch: 46 summary: In a recent pilot of awake proning in patients with COVID-19 at one New York emergency department, the median SpO 2 improved from 84% to 94%. Once the pandemic has abated, there may be a role for awake proning in patients with other respiratory illness/infection who are proving difficult to oxygenate in the more conventional supine position, though further studies are required to validate it as an effective treatment. keywords: covid-19; oxygen; patients; proning cache: cord-355146-6rat5j64.txt plain text: cord-355146-6rat5j64.txt item: #2847 of 2876 id: cord-355177-62v1qhia author: Emery, Andrew Robert title: A Novel Approach to Fiberoptic Intubation in COVID-19 Patients date: 2020-07-24 words: 3371 flesch: 49 summary: Additionally, Matava et al 3 also showed that the disposable plastic drapes of intubation hoods could be rolled up and disposed of without causing additional contamination to health care providers, 3 thus further validating the safety of disposable drape hoods and our design. Thus, the purpose of this study is to describe a novel approach to fiberoptic barrier (FOB) intubation in COVID-19 risk patients. keywords: airway; foi; hood; intubation; patients; pressure; pvc cache: cord-355177-62v1qhia.txt plain text: cord-355177-62v1qhia.txt item: #2848 of 2876 id: cord-355190-ytdw1d5v author: Mok, Chi Chiu title: Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date: 2020-09-11 words: 3770 flesch: 46 summary: A substantial proportion of SLE patients still succumbed of complications related to refractory disease or therapies (6) . This is a survival study of an inception cohort of SLE patients diagnosed since 1995. keywords: damage; group; lupus; patients; sle; survival; years cache: cord-355190-ytdw1d5v.txt plain text: cord-355190-ytdw1d5v.txt item: #2849 of 2876 id: cord-355191-jghvq3cy author: Yang, Yang title: A Rare Case of Immune Thrombocytopenic Purpura Secondary to COVID‐19 date: 2020-05-22 words: 654 flesch: 52 summary: Studies have shown that coagulation dysfunction is one of the important reason causing death of COVID‐19 patients and appeared in many patients. Studies have shown that coagulation dysfunction is one of the important reason causing death of COVID-19 patients, and 71% of death patients achieved the diagnostic criteria of the International Society for blood clots bleeding (International Society on Thrombosis and Haemostasis, ISTH) of disseminated intravascular coagulation (disseminated intravascular coagulation, DIC) 2 . keywords: coronavirus; covid‐19 cache: cord-355191-jghvq3cy.txt plain text: cord-355191-jghvq3cy.txt item: #2850 of 2876 id: cord-355264-ygzh8von author: Florez-Perdomo, William Andrés title: Relationship between the history of cerebrovascular disease and mortality in COVID-19 patients: a systematic review and meta-analysis date: 2020-08-25 words: 1647 flesch: 41 summary: asymmetry, indicating that there is no publication bias; however, due to the low number of included studies, we could not rule out or confirm the presence of bias. The quality of included studies was assessed and it was found that three of the included studies obtained a score of five, considering that 42.28% of the included studies were of moderate quality, three studies (42.28%) were of moderate high quality obtaining a score of 6/7 and the one study obtained a score of 7/7, considering it the only included study of high quality (see Table 2 ). keywords: disease; patients; risk; studies cache: cord-355264-ygzh8von.txt plain text: cord-355264-ygzh8von.txt item: #2851 of 2876 id: cord-355294-gifsqph6 author: García-Suárez, Julio title: Impact of hematologic malignancy and type of cancer therapy on COVID-19 severity and mortality: lessons from a large population-based registry study date: 2020-10-08 words: 4738 flesch: 37 summary: Patients with hematologic malignancies typically are known to have higher levels of immunosuppression and may develop more severe respiratory viral infections than patients with solid tumors. A large-scale study using UK Coronavirus Cancer Monitoring Project data gave consistent findings [9] . Patients with hematologic malignancies usually have higher levels of immunosuppression and may develop more severe respiratory viral infections than patients with solid tumors [10] . keywords: cancer; covid-19; data; disease; hematologic; malignancies; mortality; patients; severity; study; therapy cache: cord-355294-gifsqph6.txt plain text: cord-355294-gifsqph6.txt item: #2852 of 2876 id: cord-355296-46jf56nc author: Goldstein, David P. title: Tracheoesophageal voice prosthesis management in laryngectomy patients during the COVID-19 pandemic date: 2020-08-10 words: 3057 flesch: 42 summary: While there is no data to suggest that tracheal and nasopharyngeal swabs will be discordant in laryngectomy patients, there are reports in the general population of COVID-19 positive patients demonstrating that nasopharyngeal swabs and tracheal aspirates can be discordant [13] . Since coronavirus is transmitted through respiratory droplets or aerosolization of virus from the upper aerodigestive tract (UADT), aerosol generating procedures (AGPs), such as those frequently performed in Otolaryngology-Head and Neck Surgery, can put health care workers at significant risk of transmission of the virus when performed in COVID-19 positive patients [4] [5] [6] . keywords: change; covid-19; patients; prosthesis; screening; tep; voice cache: cord-355296-46jf56nc.txt plain text: cord-355296-46jf56nc.txt item: #2853 of 2876 id: cord-355384-qa7grviy author: NaserEddin, Adeeb title: Bacillus Calmette–Guerin (BCG) Vaccine-associated Complications in Immunodeficient Patients Following Stem Cell Transplantation date: 2020-10-27 words: 4280 flesch: 36 summary: BCG vaccines: Their mechanisms of attenuation and impact on safety and protective efficacy BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies Bacille Calmette-Guerin vaccine-induced disease in HIVinfected and HIV-uninfected children Clinical characteristics and immunogenetics of BCGosis/BCGitis in Chinese children: a 6 year follow-up study Primary Immunodeficiency Diseases and Bacillus Calmette-Guérin (BCG)-vaccine-derived complications: a systematic review Bacillus Calmette-Guérin (BCG) complications associated with primary immunodeficiency diseases Disseminated Bacillus Calmette-Guérin (BCG) infections in infants with immunodeficiency Immunologic aspects of patients with disseminated bacille Calmette-Guerin disease in north-west of Iran Immune defects in active mycobacterial diseases in patients with primary immunodeficiency diseases (PIDs) Life-threatening infections due to live-attenuated vaccines: early manifestations of inborn errors of immunity Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries Mycobacterial disease in patients with chronic granulomatous disease: a retrospective analysis of 71 cases International Union of Immunological Societies: 2017 primary immunodeficiency diseases committee report on inborn errors of immunity Defining combined immunodeficiency Clinical manifestations of graft-versus-host disease in human recipients of marrow from hl-a-matched sibling donors1 Deep intronic mis-splicing mutation in JAK3 gene underlies T-B+NK-severe combined immunodeficiency phenotype Severe cutaneous bacillus Calmette-Guérin infection in immunocompromised children: the relevance of skin biopsy Successful treatment of BCG-related immune reconstitution inflammatory syndrome following ex vivo T-cell-depleted haploidentical hematopoietic stem cell transplantation: a case report Primary immunodeficiency diseases and Bacillus Calmette-Guérin (BCG)-vaccine-derived complications: a systematic review An unconditioned bone marrow transplantation in a child with purine nucleoside phosphorylase deficiency and its unique complication Hematopoietic stem cell transplantation for children with primary immunodeficiency diseases: single center experience in Jordan Successful handling of disseminated BCG disease in a child with severe combined immunodeficiency Disseminated bacillus Calmette-Guérin infection and immunodeficiency Successful bone marrow transplantation and treatment of BCG infection in two patients with severe combined immunodeficiency An intensive approach to the treatment of disseminated BCG infection in a SCID patient BCG-related inflammatory syndromes in severe combined immunodeficiency after TCRαβ+/CD19+ depleted HSCT Successful unrelated mismatched cord blood transplantation in an infant with severe combined immunodeficiency and Mycobacterium bovis bacillus Calmette-Guèrin disease Disseminated BCG infection following bone marrow transplantation for X-linked severe combined immunodeficiency Disseminated BCG infection in severe combined immunodeficiency presenting with severe anaemia and associated with gross hypersplenism after bone marrow transplantation Expansion of γδt cells in an infant with severe combined immunodeficiency syndrome after disseminated BCG infection and bone marrow transplantation Molecular diagnosis of severe combined immunodeficiencyidentification of IL2RG, JAK3, IL7R, DCLRE1C, RAG1, and RAG2 mutations in a cohort of Chinese and Southeast Asian children Successful management of cutaneous BCG dissemination in a child affected by SCID and receiving allogeneic hematopoietic stem cell transplant Successful second bone marrow transplantation in Omenn's syndrome after bone marrow aplasia: a case report Hemophagocytic bone marrow aplasia with plasma cells in a RAG2-deficient SCID case after a nonconditioned transplantation from a fully matched sibling Bacillus calmette-guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation Successful unrelated cord blood stem cell transplantation in an X-linked chronic granulomatous disease patient with disseminated BCG-induced infection Immune Responses to Bacillus Calmette-Guérin vaccination: why do they fail to protect against Mycobacterium tuberculosis? We recorded baseline patient characteristics, timing, and nature of BCG complications, prophylactic and treatment regimens, immunological work up, transplant characteristics, and outcome. keywords: bcg; bcgosis; cell; complications; hsct; immunodeficiency; infection; patients; post; transplant cache: cord-355384-qa7grviy.txt plain text: cord-355384-qa7grviy.txt item: #2854 of 2876 id: cord-355431-efwuy8p9 author: Ambrosio, Luca title: The role of the orthopaedic surgeon in the COVID-19 era: cautions and perspectives date: 2020-05-27 words: 4993 flesch: 35 summary: Hospitals have been restructured to provide the best care to COVID-19 patients while adopting preventive strategies not to spread the infection among healthcare providers and patients affected by other diseases. In all other situations, wearing a surgical mask is reasonably safe when providing direct care to COVID-19 patients, especially in case of respirator scarcity [51, 58] . keywords: care; cases; coronavirus; covid-19; health; healthcare; orthopaedic; pandemic; patients; ppe; risk; surgery; use cache: cord-355431-efwuy8p9.txt plain text: cord-355431-efwuy8p9.txt item: #2855 of 2876 id: cord-355484-2igc5wzx author: Oteo, J. A. title: A short therapeutic regimen based on hydroxychloroquine plus azithromycin for the treatment of COVID-19 in patients with non-severe disease. A strategy associated with a reduction in hospital admissions and complications. date: 2020-06-12 words: 3377 flesch: 54 summary: At the time of writing this paper no medical therapy is officially recommended or has shown results in improving the outcomes in COVID-19 patients. At the time of writing this paper no medical therapy is officially recommended or has shown results in improving the outcomes in COVID-19 patients (5). keywords: days; hospital; license; patients; preprint cache: cord-355484-2igc5wzx.txt plain text: cord-355484-2igc5wzx.txt item: #2856 of 2876 id: cord-355504-zsyvgm9c author: Feng, Feng title: Longitudinal changes of pneumonia complicating novel influenza A (H1N1) by high-resolution computed tomography date: 2015-06-09 words: 3813 flesch: 46 summary: The longitudinal followups by HRCT can serve as a useful tool to assess pulmonary changes and sequelae in patients recovering from pneumonia complicating influenza A (H1N1). To assess lung lesions in patients with pneumonia complicating novel influenza A (H1N1) by serial high-resolution computed tomography (HRCT) during the early, progressive and convalescent stages. keywords: h1n1; hrct; influenza; lung; patients; scans cache: cord-355504-zsyvgm9c.txt plain text: cord-355504-zsyvgm9c.txt item: #2857 of 2876 id: cord-355524-qx396wq1 author: Rao, P Vishnu title: Clinical profile of respiratory viral infections: A study from tertiary care centre of South India date: 2017-09-30 words: 2333 flesch: 43 summary: The recent influenza pandemic caused by the 2009 California H1N1strain increased awareness of the importance of influenza among hospitalized patients but there are few reports on other influenza strains and other non influenza respiratory viral infections in hospitalised patients. The recent influenza pandemic caused by the 2009 California H1N1strain increased awareness of the importance of influenza among hospitalized patients but there are few reports on other influenza strains and other non influenza respiratory viral infections in hospitalised patients 6 . keywords: infections; influenza; patients; study; viruses cache: cord-355524-qx396wq1.txt plain text: cord-355524-qx396wq1.txt item: #2858 of 2876 id: cord-355528-y4a1g6km author: Balla, Mamtha title: COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective date: 2020-03-30 words: 7523 flesch: 53 summary: Patients can catch it by breathing in droplets if they are standing within 1 m of COVID-19 patients. Drills and emergency preparedness about COVID-19 should be performed in all health care facilities involving providers who will be in touch with COVID-19 suspected patients. keywords: cases; china; coronavirus; covid-19; disease; et al; health; infection; novel; patients; pneumonia; sars; treatment cache: cord-355528-y4a1g6km.txt plain text: cord-355528-y4a1g6km.txt item: #2859 of 2876 id: cord-355533-5kgdg2nb author: Kline, Jonathan D title: Sentinel Case of COVID-19 at Fort Stewart, GA in a National Guard Soldier Participating in Annual Training: A Case Report date: 2020-06-22 words: 2151 flesch: 39 summary: This facility does not boast a true intensive care unit (ICU) capability, but a dedicated wing of the intermediate care ward was quickly outfitted, staffed, and isolated for the sole purpose of longterm management of COVID-19 patients in the event that transfer to an off-installation ICU was denied because of civilian hospitals reaching capacity. Interim guidelines for the clinical management of COVID-19 positive patients are available online and frequently updated. keywords: coronavirus; covid-19; health; infection; patient; symptoms cache: cord-355533-5kgdg2nb.txt plain text: cord-355533-5kgdg2nb.txt item: #2860 of 2876 id: cord-355549-6xnjj5h5 author: Cécile, Couchoud title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 words: 4018 flesch: 44 summary: key: cord-355549-6xnjj5h5 authors: Cécile, Couchoud; Florian, Bayer; Carole, Ayav; Clémence, Béchade; Philippe, Brunet; François, Chantrel; Luc, Frimat; Roula, Galland; Maryvonne, Hourmant; Emmanuelle, Laurain; Thierry, Lobbedez; Lucile, Mercadal; Olivier, Moranne title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. 6xnjj5h5 The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. keywords: care; covid-19; dialysis; disease; france; mortality; patients; population; risk cache: cord-355549-6xnjj5h5.txt plain text: cord-355549-6xnjj5h5.txt item: #2861 of 2876 id: cord-355558-r6r1t47c author: Shenoy, Akhil title: Diabetes and covid-19: a global health challenge date: 2020-04-27 words: 1435 flesch: 46 summary: It may also be cautioned that severe covid-19 patients with diabetes were older in age and had associated comorbidities including hypertension, cardiovascular disease and cerebrovascular disease than the non-diabetic patients (although even after adjustment for these comorbidities, patients with diabetes had a lower survival rate than nondiabetics). Taken together, diabetes may be associated with a higher risk of severe covid-19 disease and a necessity for mechanical ventilation as well as risk of death. keywords: covid-19; diabetes; disease; patients cache: cord-355558-r6r1t47c.txt plain text: cord-355558-r6r1t47c.txt item: #2862 of 2876 id: cord-355589-3zdv9zim author: Simons, David title: The association of smoking status with SARS‐CoV‐2 infection, hospitalisation and mortality from COVID‐19: A living rapid evidence review with Bayesian meta‐analyses (version 7) date: 2020-10-02 words: 5238 flesch: 31 summary: A Hospital Staff Data Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan Acute Myocardial Injury of Patients with Coronavirus Disease Epidemiological and Clinical Characteristics of 17 Hospitalized Patients with 2019 Novel Coronavirus Infections Outside Wuhan Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Patients in Wuhan Epidemiological and clinical features of 125 Hospitalized Patients with COVID-19 in Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 -United States Eleven faces of coronavirus disease 2019 Clinical Course and Outcomes of Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection: a Preliminary Report of the First 28 Patients from the Korean Cohort Study on COVID-19 Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series COVID-19 Fatality and Comorbidity Risk Factors among Confirmed Patients in Mexico Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Cluster of COVID-19 in northern France: A retrospective closed cohort study Letter to the Editor: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease Clinical Characteristics and Risk factors for developed COVID-19 patients transferring to designated hospital from Jianghan Fangcang shelter Hospital: a retrospective, observational study Clinical features of coronavirus disease 2019 (COVID-19) in a cohort of patients with disability due to spinal cord injury Clinical characteristics of imported and second-generation COVID-19 cases outside Wuhan, China: A multicenter retrospective study Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients Characteristics and Clinical Outcomes of Adult Patients Hospitalized with COVID-19 -Georgia Association Between Clinical Manifestations and Prognosis in Patients with COVID-19 Epidemiological and clinical characteristics analysis of COVID-19 in the surrounding areas of Wuhan, Hubei Province in 2020 Low albumin levels are associated with poorer outcomes in a case series of COVID-19 patients in Spain: a retrospective cohort study Clinical characteristics of 106 patients with neurological diseases and co-morbid coronavirus disease 2019: a retrospective study Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 Smoking and the risk of COVID-19 infection in the UK Biobank Prospective Study Multivariable prediction model of intensive care unit transfer and death: a French prospective cohort study of COVID-19 patients Determinants of Severity in Cancer Patients with COVID-19 Illness OpenSAFELY: factors associated with COVID-19 death in 17 million patients A Cohort of Patients with COVID-19 in a Major Teaching Hospital in Europe 30-day mortality in patients hospitalized with COVID-19 during the first wave of the Italian epidemic: A prospective cohort study Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: a comparison of patients with and without COVID-19 Clinical and Genetic Characteristics of Covid-19 Patients from UK Biobank Is sleep apnoea a risk factor for Covid-19? First report from Saudi Arabia Risk of infection and hospitalization by Covid-19 in Mexico: a case-control study Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry Olfactory Dysfunction in Recovered Coronavirus Disease 2019 (COVID-19) Patients Psychosocial factors and hospitalisations for COVID-19: Prospective cohort study of the general population Clinical predictors of donor antibody titer and correlation with recipient antibody response in a COVID-19 convalescent plasma clinical trial Chronic ACE Inhibitor use is Associated with Decreased Odds of Severe Disease in Patients with COVID-19 Intraluminal Carotid Artery Thrombus in COVID-19: Another Danger of Cytokine Storm? Impact of SARS-CoV-2 Viral Load on Risk of Intubation and Mortality Among Hospitalized Patients with Coronavirus Disease IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections Profiling pre-symptomatic and asymptomatic cases with confirmed SARS-CoV-2 infection in Mexico City Association of SARS-CoV-2 Genomic Load with COVID-19 Patient Outcomes Health-care workers with COVID-19 living in Mexico City: clinical characterization and related outcomes ROX Index Predicts Intubation in Patients with COVID-19 Pneumonia and Moderate to Severe Hypoxemic Respiratory Failure Receiving High Flow Nasal Therapy Low plasma 25(OH) vitamin D3 level is associated with increased risk of COVID-19 infection: an Israeli population-based study Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank Association of Cancer with Risk and Mortality of COVID-19: Results from the UK Biobank Natural killer cell activation related to clinical outcome of COVID-19 Digestive Manifestations in Patients Hospitalized with COVID-19 Risk Factors Prediction, Clinical Outcomes, and Mortality of COVID-19 Patients Early Diagnosis and Clinical Significance of Acute Cardiac Injury -Under the Iceberg: A Retrospective Cohort Study of 619 Non-critically Ill Hospitalized COVID-19 Pneumonia Patients Clinical outcomes and risk factors for severe COVID-19 infection in patients with haematological disorders receiving chemo-or immunotherapy Initial experience in Mexico with convalescent plasma in COVID-19 patients with severe respiratory failure, a retrospective case series Observational Study of Haloperidol in Hospitalized Patients with Covid-19 COVID-19 Case Series at UnityPoint Health St. Lukes Hospital in Cedar Rapids Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome IgG antibody seroconversion and the clinical progression of COVID-19 pneumonia: keywords: clinical; covid-19; disease; patients; risk; smokers; smoking; status; studies; study cache: cord-355589-3zdv9zim.txt plain text: cord-355589-3zdv9zim.txt item: #2863 of 2876 id: cord-355885-pg6mpuk5 author: Saracoglu, Kemal T. title: Airway management strategies for the Covid 19 patients: A brief narrative review date: 2020-06-01 words: 516 flesch: 28 summary: The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing Staff Safety During Emergency Airway Management for COVID-19 in Hong Kong COVID-19: Respiratory support outside the intensive care unit Consensus guidelines for managing the airway in patients with COVID-19: Guidelines from the Difficult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetists Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group Peri-operative Considerations in Urgent Surgical Care of Suspected and Confirmed COVID-19Orthopedic key: cord-355885-pg6mpuk5 authors: Saracoglu, Kemal T.; Saracoglu, Ayten; Demirhan, Recep title: Airway management strategies for the Covid 19 patients: A brief narrative review date: 2020-06-01 journal: J Clin Anesth DOI: 10.1016/j.jclinane.2020.109954 sha: doc_id: 355885 cord_uid: pg6mpuk5 • Airway management of patients with Covid-19 is a high risk procedure. keywords: airway; patients cache: cord-355885-pg6mpuk5.txt plain text: cord-355885-pg6mpuk5.txt item: #2864 of 2876 id: cord-355898-hlkwwaqe author: Grippo, Antonello title: Electroencephalography during SARS-CoV-2 outbreak: practical recommendations from the task force of the Italian Society of Neurophysiology (SINC), the Italian League Against Epilepsy (LICE), and the Italian Association of Neurophysiology Technologists (AITN) date: 2020-07-21 words: 3950 flesch: 29 summary: The most representative scientific societies of health professionals involved in the EEG execution and reporting, Italian Society of Clinical Neurophysiology (SINC), Italian League Against Epilepsy (LICE), and the Italian Association of Neurophysiology Technologists (AITN), received several requests for indications on how to perform EEG examinations during this health emergency from their members. In addition, due to the reduction in the volume of EEG examinations, it should be considered that medical staff may be able to work on alternate days or rotating shifts to limit exposure to the infection, or may be moved to other areas depending on the needs of the hospital. keywords: covid-19; eeg; emergency; equipment; examination; italian; pandemic; patients; phase; procedures; recommendations cache: cord-355898-hlkwwaqe.txt plain text: cord-355898-hlkwwaqe.txt item: #2865 of 2876 id: cord-356040-qdpkidn8 author: Ghazawi, Feras M. title: Infection risk of dermatologic therapeutics during the COVID‐19 pandemic: an evidence‐based recalibration date: 2020-07-03 words: 4170 flesch: 23 summary: We performed a literature review to approximate the risk of SARS‐CoV‐2 infection, including available data on the roles of relevant cytokines, cell subsets, and their mediators in eliciting an optimal immune response against respiratory viruses in murine gene deletion models and humans with congenital deficiencies were reviewed for viral infections risk and if possible coronaviruses specifically. One systematic review evaluating the off-label use of azathioprine found mild infections reported in 0.36% of patients and severe infections in only 0.30% of patients 70 (Table 3 ). keywords: coronavirus; covid-19; efficacy; infection; patients; placebo; psoriasis; risk; safety; treatment; trial cache: cord-356040-qdpkidn8.txt plain text: cord-356040-qdpkidn8.txt item: #2866 of 2876 id: cord-356056-82bvcuvd author: Shaikh, Aasef G. title: Cerebellar Scholars’ Challenging Time in COVID-19 Pandemia date: 2020-04-16 words: 1344 flesch: 50 summary: There is an urgent need to develop novel platforms to assess and follow ataxic patients remotely, especially because cerebellar patients often require ambulatory care to maintain their autonomy. Clinical features of patients infected with 2019 novel coronavirus in Wuhan Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross sectional study The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus infection, and proposed neurotropic mechanisms Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Conflict of Interest keywords: covid-19; novel; patients; time cache: cord-356056-82bvcuvd.txt plain text: cord-356056-82bvcuvd.txt item: #2867 of 2876 id: cord-356057-87kxlqdc author: Chagas, Aline Lopes title: Management of Hepatocellular Carcinoma during the COVID-19 Pandemic - São Paulo Clínicas Liver Cancer Group Multidisciplinary Consensus Statement date: 2020-10-15 words: 4365 flesch: 41 summary: Patients with chronic liver disease and solitary tumors that are 43 cm in size: J Consider performing surgery for patients who have preserved liver function, have no clinically significant portal hypertension or other comorbidities, are young, and present with favorable locations for resection (19, 21 The indications for LT are also similar to those before the pandemic (18) (19) (20) . The COVID-19 pandemic can significantly impact the management of HCC patients from diagnosis to treatment strategies. keywords: cancer; covid-19; hcc; liver; pandemic; patients; risk; treatment cache: cord-356057-87kxlqdc.txt plain text: cord-356057-87kxlqdc.txt item: #2868 of 2876 id: cord-356084-621qzpqd author: Qu, Jiuxin title: Profile of IgG and IgM antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) date: 2020-04-27 words: 1579 flesch: 51 summary: [9] , and we detected high levels of IgG antibody in critical patients. Delayed, but stronger antibody responses were observed in critical patients. keywords: igg; igm; patients; sars cache: cord-356084-621qzpqd.txt plain text: cord-356084-621qzpqd.txt item: #2869 of 2876 id: cord-356127-xy5tyd7t author: Omidi, Negar title: Prosthetic heart valves and the COVID‐19 pandemic era: What should we be concerned about? date: 2020-09-28 words: 1550 flesch: 41 summary: The Lancet Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines Clinical features and treatment of COVID-19 patients in northeast Chongqing Case of the index patient who caused tertiary transmission of COVID-19 infection in Korea: the application of lopinavir/ritonavir for the treatment of COVID-19 infected pneumonia monitored by quantitative RT-PCR Interaction between lopinavir/ ritonavir and warfarin Ritonavir and warfarin interaction Bleeding events following concurrent use of warfarin and oseltamivir by medicare beneficiaries Angiotensinconverting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target Coagulopathy and antiphospholipid antibodies in patients with Covid-19 Viral infections and antiphospholipid antibodies Prosthetic heart valves and the COVID-19 pandemic era: What should we be concerned about? Patients with prosthetic valve replacement with coronavirus disease 2019 (COVID- 19) infection are a challenging subset of patients to manage. keywords: covid-19; heart; patients; warfarin cache: cord-356127-xy5tyd7t.txt plain text: cord-356127-xy5tyd7t.txt item: #2870 of 2876 id: cord-356195-5pcaxpp9 author: Jothimani, Dinesh title: COVID-19 and Liver. date: 2020-06-15 words: 3977 flesch: 41 summary: Caution needs to be exercised when considering initiation of steroids or other immunosuppressive therapy in liver disease patients e.g.; Severe alcoholic hepatitis, Auto immune hepatitis etc 31 . His PCR remained positive for nearly 2 months and subsequently cleared 72 Literature from SARS-CoV and MERS show that post liver transplant patients on immunosuppression were not at risk for high mortality. keywords: ace2; clinical; coronavirus; covid-19; disease; infection; liver; patients; sars; syndrome cache: cord-356195-5pcaxpp9.txt plain text: cord-356195-5pcaxpp9.txt item: #2871 of 2876 id: cord-356215-0nypfw48 author: Hu, Xiaojing title: Management practices of emergency departments in general hospitals based on blockage of chain of infection during a COVID-19 epidemic date: 2020-09-18 words: 4391 flesch: 40 summary: The balance between meeting the needs of emergency patients during the epidemic as well as promptly screening and safely transferring high-risk infections to avoid cross-infection among doctors, patients, and medical staff has become an important scientific issue which posed great challenges for emergency departments (ED). The admission process for emergency patients is indicated as follows: Professionals of Prevention and Control of Healthcareassociated Infections Department Department visited the ED daily to conduct on-site supervision and improvement, including environment and equipment disinfection, ventilation (such as timely removal of the curtain after a rise in temperature), hand hygiene of medical personnel, and sewage and sewage treatment. keywords: control; coronavirus; covid-19; department; emergency; epidemic; infection; patients; prevention; staff cache: cord-356215-0nypfw48.txt plain text: cord-356215-0nypfw48.txt item: #2872 of 2876 id: cord-356246-4p0ok1mc author: Ammirati, Enrico title: Heart-Kidney Transplanted patient affected by COVID-19 pneumonia treated with tocilizumab on top of immunosuppressive maintenance therapy date: 2020-07-17 words: 1204 flesch: 39 summary: Potential complications after the administration of tocilizumab in COVID-19 patients to be aware of include septic shock, and gastrointestinal perforation On admission day, temperature was 37.5°C, blood pressure keywords: day; patient; tocilizumab cache: cord-356246-4p0ok1mc.txt plain text: cord-356246-4p0ok1mc.txt item: #2873 of 2876 id: cord-356332-t0ahmh0h author: Elkattawy, Sherif title: A Rare Complication of Myocardial Infarction: Ventricular Septal Defect date: 2020-08-13 words: 2193 flesch: 45 summary: Postinfarction ventricular septal rupture Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction Hemodynamic complications of ventricular septal rupture after acute myocardial infarction Ventricular septal defect: early against late surgical repair Trends in the clinical and pathological characteristics of cardiac rupture in patients with acute myocardial infarction over 35 years In-hospital outcome of patients with post-MI VSD: a single-center study Surgical management of post-infarction ventricular septal defect, mitral regurgitation and ventricular aneurysm Factors related to heart rupture in acute coronary syndromes in the Global Registry of Acute Coronary Events Management of post-myocardial infarction ventricular septal defects: a critical assessment Acute mechanical complications in patients suffering from acute myocardial infarction. Ventricular septal rupture (VSR) can occur following both anterior and inferior MI. keywords: infarction; patient; rupture; septal; ventricular cache: cord-356332-t0ahmh0h.txt plain text: cord-356332-t0ahmh0h.txt item: #2874 of 2876 id: cord-356349-ey5vnddu author: Fusco, Francesco M title: Infection control management of patients with suspected highly infectious diseases in emergency departments: data from a survey in 41 facilities in 14 European countries date: 2012-01-28 words: 4041 flesch: 39 summary: Most partners are clinicians working in isolation facilities designated for referral of patients with HIDs. As the main target of the project were isolation facilities for HID cases, the EDs and MADs surveyed are operating within, or in the same hospital compound, as a regional/national reference hospital for infectious diseases: thus, we believe that the occurrence of HIDs is more likely in these facilities, due to referral of suspected patients from other medical facilities or to selfreferral of patient returning from endemic countries for HID. keywords: diseases; eds; facilities; hids; isolation; mads; management; patients; procedures cache: cord-356349-ey5vnddu.txt plain text: cord-356349-ey5vnddu.txt item: #2875 of 2876 id: cord-356371-w9ejgzvu author: Torres-González, JI title: What has happened to care during the COVID-19 pandemic? date: 2020-07-28 words: 2276 flesch: 38 summary: -Benchmark ECMO Units with a well defined team (ECMO-Team) were able to quickly implement this therapy to a larger number of patients and to adapt care required by this type of patient with the COVID pathology. What may be a complex decision was greatly simplified with COVID-19 patients because it was highly evident when treatment did not work. keywords: care; icu; patients; sedation; seeiuc cache: cord-356371-w9ejgzvu.txt plain text: cord-356371-w9ejgzvu.txt item: #2876 of 2876 id: cord-356379-e8ohc25w author: Wu, Qiuji title: Recovery from COVID‐19 in two patients with coexisted HIV infection date: 2020-05-13 words: 696 flesch: 56 summary: Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China SARS-CoV-2 Transmission in Patients With Cancer at a Tertiary Care Hospital in Wuhan, China Co-infection of SARS-CoV-2 and HIV in a patient in Wuhan city Clinical Characteristics of Coronavirus Disease 2019 in China Could HIV infection alter the clinical course of SARS-CoV-2 infection? The experience of these two cases suggested that COVID‐19 patients with HIV infection could still have satisfactory clinical outcomes following proper medical care. keywords: patient cache: cord-356379-e8ohc25w.txt plain text: cord-356379-e8ohc25w.txt