# bib

id: cord-264571-rtac6hh2
author: Bhatia, Saurabh
title: Chapter 9 Edible Vaccines
date: 2015-12-31
extension: .txt
mime: text/plain
words: 2752
sentence: 125
flesch: 42
cache: cache/cord-264571-rtac6hh2.txt
txt: txt/cord-264571-rtac6hh2.txt
summary:
  Reported expression rates range from 0.01% to 2% total soluble protein (TSP), which can render edible vaccine proteins less immunogenic. In addition, unlike almost all other cell lines used for production of vaccines, components of plant cells have always been an important part of the normal human diet.


id: cord-330827-gu2mt6zp
author: Shanmugaraj, Balamurugan
title: Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development
date: 2020-02-22
extension: .txt
mime: text/plain
words: 3748
sentence: 125
flesch: 32
cache: cache/cord-330827-gu2mt6zp.txt
txt: txt/cord-330827-gu2mt6zp.txt
summary:
  [60] [61] , the monoclonal antibodies that are identified and tested to be effective against SARS virus protein or specific to ACE2 can be produced in plants and shall be tested for its efficacy against nCoV. Earlier reports showed several vaccines and monoclonal antibody candidates in response to SARS-CoV and MERS-CoV, which could be tested and used for passive immunotherapy for an immediate immune response [62] [63] Currently, plant expression system offers many advantages over other conventional systems that have the potential to tackle the production of vaccine candidates rapidly at affordable cost facilitating the global vaccination programs, especially in resource-poor nations where the vaccines are needed most [15] .


id: cord-292019-rfu0bkag
author: Gómez, N.
date: 1998-09-30
extension: .txt
mime: text/plain
words: 3601
sentence: 116
flesch: 35
cache: cache/cord-292019-rfu0bkag.txt
txt: txt/cord-292019-rfu0bkag.txt
title:
  Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants

summary:
  key: cord-292019-rfu0bkag authors: Gómez, N.; Carrillo, C.; Salinas, J.; Parra, F.; Borca, M. V.; Escribano, J. M. title: Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants date: 1998-09-30 journal: Virology DOI: 10.1006/viro.1998.9315 sha: doc_id: 292019 cord_uid: rfu0bkag Abstract The use of transgenic plants as vaccine production systems was described recently. We report on the immunological response elicited by two recombinant versions of the glycoprotein S from the swine-transmissible gastroenteritis coronavirus (TGEV) expressed in transgenic plants.


id: cord-353454-zq51hpjs
author: Gouda, Sushanto
title: Endophytes: A Treasure House of Bioactive Compounds of Medicinal Importance
date: 2016-09-29
extension: .txt
mime: text/plain
words: 4008
sentence: 124
flesch: 23
cache: cache/cord-353454-zq51hpjs.txt
txt: txt/cord-353454-zq51hpjs.txt
summary:
  Mycoplasma species are also reported as plant endophytes. Normally, the specific endophytes interaction with various plants and evidence of their strategy of existence and transmission is provided by their genome organization (Andreote et al., 2014) .


id: cord-322926-xlwsj3v2
author: Shanmugaraj, Balamurugan
title: Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production
date: 2020-07-04
extension: .txt
mime: text/plain
words: 4670
sentence: 130
flesch: 15
cache: cache/cord-322926-xlwsj3v2.txt
txt: txt/cord-322926-xlwsj3v2.txt
summary:
  Considering the low costs and greater scalability of plant production systems, the commercialization of non-pharmaceutical proteins is straightforward and faster due to lower regulatory challenges. In this review, we consider the importance of a plant- based production system for recombinant protein production, and its potential to produce biopharmaceuticals is discussed.


id: cord-258927-masvn1gu
author: Soria-Guerra, Ruth Elena
date: 2009-03-21
extension: .txt
mime: text/plain
words: 5756
sentence: 214
flesch: 42
cache: cache/cord-258927-masvn1gu.txt
txt: txt/cord-258927-masvn1gu.txt
title:
  Expression of a multi-epitope DPT fusion protein in transplastomic tobacco plants retains both antigenicity and immunogenicity of all three components of the functional oligomer

summary:
  Male BALB/c mice, 12-to 14-week-old, (Harlan Sprague Dawley, Inc., Indianapolis, IN) were used for evaluation of the immune response against DPT protein. key: cord-258927-masvn1gu authors: Soria-Guerra, Ruth Elena; Alpuche-Solís, Angel G.; Rosales-Mendoza, Sergio; Moreno-Fierros, Leticia; Bendik, Elise M.; Martínez-González, Luzmila; Korban, Schuyler S. title: Expression of a multi-epitope DPT fusion protein in transplastomic tobacco plants retains both antigenicity and immunogenicity of all three components of the functional oligomer date: 2009-03-21 journal: Planta DOI: 10.1007/s00425-009-0918-2 sha: doc_id: 258927 cord_uid: masvn1gu Expression of genes in plant chloroplasts provides an opportunity for enhanced production of target proteins.


id: cord-350846-8gxkwi9n
author: Farrar, Ashley J.
title: Clinical Aromatherapy
date: 2020-09-28
extension: .txt
mime: text/plain
words: 6345
sentence: 371
flesch: 51
cache: cache/cord-350846-8gxkwi9n.txt
txt: txt/cord-350846-8gxkwi9n.txt
summary:
  Essential oils can be dangerous and toxic, with some being flammable, causing skin dermatitis, being phototoxic with risk of a chemical burn, or causing oral toxicity or death. Aromatherapy regulation of guidelines, plant sources for aromatic oils, and safe use of essential oils in symptom management in clinical aromatherapy is reviewed.


id: cord-329881-9vnz5zzg
author: Garcia, Sònia
title: Pandemics and Traditional Plant-Based Remedies. A Historical-Botanical Review in the Era of COVID19
date: 2020-08-28
extension: .txt
mime: text/plain
words: 6222
sentence: 183
flesch: 38
cache: cache/cord-329881-9vnz5zzg.txt
txt: txt/cord-329881-9vnz5zzg.txt
summary:
  Besides, in the USA a group of doctors known as The Eclectics got positive results by treating the flu symptoms with plant remedies, together with other measures that included exercise. Front Plant Sci DOI: 10.3389/fpls.2020.571042 sha: doc_id: 329881 cord_uid: 9vnz5zzg Pandemics are as old as humanity and since ancient times we have turned to plants to find solutions to health-related problems.


id: cord-323768-r7jbm1et
author: Lagarda-Diaz, Irlanda
title: Legume Lectins: Proteins with Diverse Applications
date: 2017-06-12
extension: .txt
mime: text/plain
words: 6815
sentence: 283
flesch: 35
cache: cache/cord-323768-r7jbm1et.txt
txt: txt/cord-323768-r7jbm1et.txt
summary:
  Throughout the history of lectin research, legume seeds have been screened for lectin activity. Among plant lectins, those of legumes have been the most widely considered [2] .


id: cord-310439-z0bxsjug
author: Martin, R. R.
title: Pathogen-Tested Planting Material
date: 2014-12-31
extension: .txt
mime: text/plain
words: 7706
sentence: 257
flesch: 42
cache: cache/cord-310439-z0bxsjug.txt
txt: txt/cord-310439-z0bxsjug.txt
summary:
  However, work with grapevines has shown that many of the viruses were related to mycoviruses rather than plant viruses (Al Rwahnih et al., 2011; Coetzee et al., 2010) . Role of international organizations Plant Diseases: Their Biology and Social Impact De novo reconstruction of consensus master genomes of plant RNA and DNA viruses from siRNAs Control of viruses affecting potatoes through seed potato certification programs Plant disease: A threat to global food security Application of high-throughput DNA sequencing in Phytopathology Molecular characterization and population structure of Blackberry vein banding associated virus, a new ampelovirus associated with blackberry yellow vein disease Certified − Feasibility of Audit-Based Certification to Prevent Invasive Plant Pests in the Horticultural Industry Profiling viral infections in grapevine using a randomly primed reverse transcription-polymerase chain reaction/macroarray multiplex platform The control of African cassava mosaic virus disease: Phytosanitation and/or resistance? Understanding and exploiting late blight resistance in the age of effectors Microarray-based detection and genotyping of viral pathogens Viral discovery and sequence recovery using DNA microarrays Certification for plant viruses


id: cord-015965-n4sjixg8
author: Sahoo, Sabuj
title: Bioprospecting of Endophytes for Agricultural and Environmental Sustainability
date: 2017-10-10
extension: .txt
mime: text/plain
words: 7482
sentence: 239
flesch: 21
cache: cache/cord-015965-n4sjixg8.txt
txt: txt/cord-015965-n4sjixg8.txt
summary:
  The interaction of the endophytic microbiota with the plants are more protected and can withstand the adverse environmental conditions and contribute to plant growth, productivity, carbon sequestration, enhanced phytoremediation efficiencies and amelioration of metal induced toxicity. The current development in endophytic research is mainly focused on evaluating endophytic microbial populations inhabiting plants, which enhances plant growth, disease resistance and the ability to tolerate or withstand the external environment.


id: cord-018724-ss8x2g3b
author: Stobbe, Anthony
title: Plant Virus Diversity and Evolution
date: 2016-06-22
extension: .txt
mime: text/plain
words: 7457
sentence: 242
flesch: 36
cache: cache/cord-018724-ss8x2g3b.txt
txt: txt/cord-018724-ss8x2g3b.txt
summary:
  Recombination between genomic RNAs of two cucumoviruses under conditions of minimal selection pressure Genetic bottlenecks during systemic movement of Cucumber mosaic virus vary in different host plants Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology Seeking agricultures ancient roots Crop pests and pathogens move polewards in a warming world Multihost experimental evolution of a plant RNA virus reveals local adaptation and host-specific mutations Concerning a contagium vivum fluidum as cause of the spot disease of tobacco leaves Integration of multiple repeats of geminiviral DNA into nuclear genome of tobacco during evolution The RNA world hypothesis: the worst hypothesis of early evolution of life (except for all the others) Role of recombination in the evolution of natural populations of Cucumber mosaic virus, a tripartite RNA plant virus High genetic diversity, distant phylogenetic relationships and intraspecies recombination events among natural populations of Yam mosaic virus: a contribution to understanding potyvirus evolution Frequent homologous recombination events between molecules of one RNA component in a multipartite RNA virus Genetic recombination in plant-infecting messenger-sense RNA viruses: overview and research perspectives A real-time RT-PCR assay for quantifying the fitness of tobacco etch virus in competition experiments Rice genomes recorded ancient pararetrovirus activities: virus genealogy and multiple origins of endogenization during rice speciation Suppression of viral RNA recombination by a host exoribonuclease Widespread endogenization of genome sequences of non-retroviral RNA viruses into plant genomes Wild plants and viruses: underinvestigated ecosystems Environmentally dependent host-pathogen and vector-pathogen interactions in the Barley yellow dwarf virus pathosystem An RNA proofreading machine regulates replication fidelity and diversity A map of the diversity of RNA3 recombinants appearing in plants infected with Cucumber mosaic virus and Tomato aspermy virus Phylogenetic evidence for rapid rates of molecular evolution in the single-stranded DNA begomovirus Tomato yellow leaf curl virus Experimental evolution of plant RNA viruses Molecular ecology and emergence of tropical plant viruses Insect vectors as drivers of plant virus emergence The major role of viruses in cellular evolution: facts and hypotheses Recombination every day: abundant recombination in a virus during a single multi-cellular host infection Founder effect, plant host, and recombination shape the emergence populations of begomoviruses that cause tomato yellow leaf curl disease in the Mediterranean basis Variation and evolution of plant virus populations Time--the emerging dimension of plant virus studies Molecular evolution of plant RNA viruses Mixed infections of Pepino mosaic virus strains modulate the evolutionary dynamics of this emergent virus Plant feeding by insect vectors can affect ife cycle, population genetics and evolution of plant viruses Citrus tristeza virus: evolution of complex and varied genotypic groups Plant virus ecology: ingredients, interactions and environmental influences Virus variation in relation to resistance-breaking in plants Origin and evolution of viruses Consequences of interspecies hybridization and virus infection on the growth and fecundity of three threatened coastal Lepidium (Brassicaceae) species from New Zealand Plant viruses alter insect behavior to enhance their spread Plant virus ecology and epidemiology: historical perspectives, recent progress and future prospects Paleovirology: inferring viral evolution from host genome sequence data Impacts of biodiversity on the emergence and transmission of infectious diseases Virus world as an evolutionary network of viruses and capsidless selfish elements Origins and evolution of viruses of eukaryotes: the ultimate modularity Plant viruses of the Almagaviridae family evolved via recombination between virusese with double-stranded and negative-strand RNA genomes Variation in phytopathogenic viruses Previously unknown and highly divergent viruses populate the oceans Environmental nutrient supply alters prevalence and weakens competitive interactions among coinfecting viruses Effect of host species on the distribution of mutational fitness effects for an RNA virus Comparative molecular epidemiology provides new insights into Zucchini yellow mosaic virus occurrence in France Evolutionary time-scale of the begomoviruses: evidence from integrated sequences in the Nicotiana genome Genetic bottlenecks reduce population variation in an experimental RNA virus population Synonymous site variation due to recombination explains higher genetic variability in begomovirus populations infecting non-cultivated hosts Widespread horizontal gene transfer from double-stranded RNA viruses to eukaryotic nuclear genomes Plasmodesmata: the intercellular organelles of green plants Virus infection in remnant native bunchgrasses from invaded California grasslands A virus responds instantly to the presence of the vector on the host and forms transmission morphs Current impact and future directions of high throughput sequencing in plant virus diagnostics Transmission mechanisms shape pathogen effects on host-vector interactions: evidence from plant viruses Infection of host plants by Cucumber mosaic virus increases the susceptibility of Myzus persicae aphis to the parasitoid Virus infection influences host plant interactions with non-vector herbivores and predators Pathogen population genetics, evolutionary potential, and durable resistance Molecular evolution of Pepino mosaic virus during long-term passaging in different hosts and its impact on virus evolution New insights into the mechanisms of RNA recombination Exploring the diversity of plant DNA viruses and their satellites using vector-enabled metagenomics on whiteflies Possible emergence of new geminiviruses by frequent recombination Long-term evolution of the Luteoviridae: time scale and mode of virus speciation Effect of biodiversity changes in disease risk: exploring disease emergence in a plant-virus system Fixation of emerging interviral recombinants in Cucumber mosaic virus populations Mapping viral functional domains for genetic diversity in plants Environment determines fidelity for an RNA virus replicase Mutation and recombination frequencies reveal a biological contrast within strains of Cucumber mosaic virus Community ecology of plant viruses. Recent efforts have expanded our knowledge of the true diversity of plant viruses by studying those viruses that infect wild, undomesticated plants.


id: cord-014901-d9szap94
author: Permyakova, N. V.
title: State of research in the field of the creation of plant vaccines for veterinary use
date: 2015-01-04
extension: .txt
mime: text/plain
words: 8092
sentence: 261
flesch: 34
cache: cache/cord-014901-d9szap94.txt
txt: txt/cord-014901-d9szap94.txt
summary:
  as a feedstuff additive Expression of hemagglutinin protein of rinderpest virus in transgenic tobacco and immunogenicity of plant derived protein in a mouse model Systemic and oral immunogenicity of hemagglutinin protein of rinderpest virus expressed by transgenic peanut plants in a mouse model Expression of hemagglutinin protein of rinderpest virus in trans genic pigeon pea Oral immunogenicity of the plant derived spike protein from swine transmissible gastroenteritis coronavirus Cloning and sequence analysis of the Korean strain of spike gene of porcine epidemic diarrhea virus and expression of its neutraliz ing epitope in plants Successful oral prime immunization with VP60 from rabbit haemorrhagic disease virus pro duced in transgenic plants using different fusion strate gies Mucosal and sys temic immunization elicited by Newcastle disease virus (NDV) transgenic plants as antigens Expres sion of the fusion glycoprotein of Newcastle disease virus in transgenic rice and its immunogenicity in mice Expression of immunogenic S1 glycoprotein of infectious bronchitis virus in trans genic potatoes Transient expression of the ectodomain of matrix protein 2 (M2e) of avian RUSSIAN Immunization with plant expressed hemagglutinin protects chickens from lethal highly pathogenic avian influenza virus H5N1 challenge infection Immunogenicity study of plant made oral subunit vaccine against porcine reproductive and res piratory syndrome virus (PRRSV) Expression of the rabies virus glycoprotein in transgenic tomatoes Immunization against rabies with plant derived antigen Development of an edible rabies vaccine in maize using the Vnukovo strain Induction of a protective immune response to rabies virus in sheep after oral immunization with transgenic maize, expressing the rabies virus glycoprotein Expression of the rabies virus nucleoprotein in plants at high levels and evaluation of immune responses in mice Expression of rabies virus G pro tein in carrots (Daucus carota) Such com panies as SemBioSys Genetics Inc. (Calgary, Can ada), Medicago Inc. (Quebec, Canada), Protalix Bio Therapeutics (Karmiel, Israel), and ORF Genetics (Iceland) proved the possibility of quick establishing of the production of purified plant proteins, which are quite competitive in today's market.


id: cord-009987-biop7gyd
author: Ali, Muhammad
date: 2017-10-19
extension: .txt
mime: text/plain
words: 7381
sentence: 264
flesch: 26
cache: cache/cord-009987-biop7gyd.txt
txt: txt/cord-009987-biop7gyd.txt
title:
  Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions

summary:
  Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: Identification of two novel hepatitis C virus subtypes Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family A review of hepatoprotective plants used in Saudi traditional medicine. Extensive literature survey of hepatoprotective plants clearly indicates that herbal drugs have an enormous potential for the treatment of liver diseases.


id: cord-322100-zkuj22oc
author: Mason, H. S.
title: Plant-Derived Antigens as Mucosal Vaccines
date: 2011-08-03
extension: .txt
mime: text/plain
words: 7970
sentence: 269
flesch: 34
cache: cache/cord-322100-zkuj22oc.txt
txt: txt/cord-322100-zkuj22oc.txt
summary:
  Thus, the prospect of plant-based expression and purification of vaccine antigens, especially virus-like particles (VLP) (Huang et al. 2009 ), for mucosal delivery is substantially brighter than that obtained using stably integrated transgenes. Plant-based expression of vaccine antigen and oral delivery of crude or minimally processed plant tissues is most promising for antigens expressed in seeds, such as rice or corn.


id: cord-294945-hcf7gsv8
author: Lin, K.H.
title: Comparative proteomic analysis of cauliflower under high temperature and flooding stresses
date: 2015-02-12
extension: .txt
mime: text/plain
words: 8231
sentence: 292
flesch: 40
cache: cache/cord-294945-hcf7gsv8.txt
txt: txt/cord-294945-hcf7gsv8.txt
summary:
  upon heat stress Drought-inhibition of photosynthesis in C3 plants: stomatal and non-stomatal limitations revisited Proteome analysis of wheat leaf under salt stress by two-dimensional difference gel electrophoresis (2D-DIGE) Comparative proteomic analysis of grain development in two spring wheat varieties under drought stress Physiology and proteome responses of two contrasting rice mutants and their wild type parent under salt stress conditions at the vegetative stage Comparative proteomic analysis of salt response proteins in seedling roots of two wheat varieties Proteome analysis of sugar beet leaves under drought stress Research on plant abiotic stress responses in the post-genome era: past, present and future Responses of antioxidative system to chilling stress in two rice cultivars differing in sensitivity Structural-functional state of thylakoid membranes of wheat genotypes under water stress Proteomic analysis of wheat embryos with 2-DE and liquid-phase chromatography (ProteomeLab PF-2D) -a For instance, proteomics approaches for the comparative analysis of protein abundance between untreated and stress-treated or tolerant and intolerant rice plants have greatly facilitated the study of plant cellular stress responses (Komatsu et al., 2003) .


id: cord-007440-7gcpk9x9
author: Koprowski, Hilary
title: Vaccines and sera through plant biotechnology()
date: 2005-03-07
extension: .txt
mime: text/plain
words: 2113
sentence: 98
flesch: 49
cache: cache/cord-007440-7gcpk9x9.txt
txt: txt/cord-007440-7gcpk9x9.txt
summary:
  However, plant production of vaccines and sera is not a simple procedure with assured success in each undertaking. Codon optimization, careful approaches to harvesting and purifying plant products, use of plant parts such as chloroplasts to increase uptake of the material are but a few potential avenues to help increase the yield of the final product.


id: cord-268149-narre5e7
author: Aziz, Muhammad Abdul
date: 2018-01-29
extension: .txt
mime: text/plain
words: 8420
sentence: 406
flesch: 45
cache: cache/cord-268149-narre5e7.txt
txt: txt/cord-268149-narre5e7.txt
title:
  Traditional uses of medicinal plants used by Indigenous communities for veterinary practices at Bajaur Agency, Pakistan

summary:
  A case study among indigenous adolescents in Oaxaca Schooling and local environmental knowledge: do they complement or substitute each other Secular changes of indigenous knowledge of useful plants: separating age and cohort effects Modernization and medicinal plant knowledge in a Caribbean horticultural village Pharmaceutical ethnobotany in the Montseny biosphere reserve (Catalonia, Iberian Peninsula). Current study revealed that the study area has sufficient knowledge on ethnoveterinary medicinal plants.


id: cord-354950-kmpbdvof
author: Demurtas, Olivia C.
title: Antigen Production in Plant to Tackle Infectious Diseases Flare Up: The Case of SARS
date: 2016-02-05
extension: .txt
mime: text/plain
words: 8662
sentence: 287
flesch: 42
cache: cache/cord-354950-kmpbdvof.txt
txt: txt/cord-354950-kmpbdvof.txt
summary:
  M protein forms homo-oligomers and interacts with S, E, and N proteins (Hogue and Machamer, 2008) . N protein has been recognized as the preferred target for detection of SARS-CoV infection by reverse transcription-polymerase chain reaction (RT-PCR; Suresh et al., 2008) .


id: cord-356019-k7gs1ohp
author: Makhzoum, Abdullah
date: 2013-08-20
extension: .txt
mime: text/plain
words: 8929
sentence: 327
flesch: 35
cache: cache/cord-356019-k7gs1ohp.txt
txt: txt/cord-356019-k7gs1ohp.txt
title:
  Recent advances on host plants and expression cassettes' structure and function in plant molecular pharming

summary:
  Moreover, protein expression in plant aerial parts could affect the growth and development of the host plant. Different ORFeome projects have thus been generated using Gateway technology for protein expression and functional analysis, such as the yeast ORFeome


id: cord-255018-dhkz23co
author: Chamorro, Melina Fernanda
date: 2020-05-24
extension: .txt
mime: text/plain
words: 8617
sentence: 386
flesch: 46
cache: cache/cord-255018-dhkz23co.txt
txt: txt/cord-255018-dhkz23co.txt
title:
  Native and exotic plants with edible fleshy fruits utilized in Patagonia and their role as sources of local functional foods

summary:
  Today we know that food plants have diverse constituents such as polyphenols, in addition to nutritional compounds. [70] as to functional species use.


id: cord-348992-8su58m68
author: Alam, Aatif
title: Technoeconomic Modeling of Plant-Based Griffithsin Manufacturing
date: 2018-07-24
extension: .txt
mime: text/plain
words: 9180
sentence: 324
flesch: 42
cache: cache/cord-348992-8su58m68.txt
txt: txt/cord-348992-8su58m68.txt
summary:
  The upstream plant growth and Griffithsin production operations are adapted from the facility layout detailed by FIGURE 5 | Upstream and downstream cost contributions by process category (units in $000). The upstream portion of the facility houses unit operations for N. benthamiana propagation, inoculation with TMV vector, and Griffithsin protein expression and accumulation.


id: cord-258489-pyfc7jde
author: Lico, Chiara
title: Viral vectors for production of recombinant proteins in plants
date: 2008-03-10
extension: .txt
mime: text/plain
words: 11098
sentence: 353
flesch: 29
cache: cache/cord-258489-pyfc7jde.txt
txt: txt/cord-258489-pyfc7jde.txt
summary:
  The heat tolerant property of the lichenase (658C) allows easy target proteins purification by heat treatment which precipitates up to 50% of contaminating plant proteins. The third strategy relies on replicating plant viruses.


id: cord-253997-imwjoecx
author: Lotter-Stark, Hester C.T.
title: Plant made anti-HIV microbicides—A field of opportunity
date: 2012-12-31
extension: .txt
mime: text/plain
words: 12008
sentence: 402
flesch: 36
cache: cache/cord-253997-imwjoecx.txt
txt: txt/cord-253997-imwjoecx.txt
summary:
  However developments in this arena have resulted in significantly improved state-of-the-art technologies for plant based protein expression. Numerous therapeutic proteins have been produced in plant systems (Giddings et al., 2000; Ma et al., 2003) .


id: cord-268590-3e1tb64o
author: Halewood, Michael
title: Germplasm Acquisition and Distribution by CGIAR Genebanks
date: 2020-10-01
extension: .txt
mime: text/plain
words: 13147
sentence: 416
flesch: 31
cache: cache/cord-268590-3e1tb64o.txt
txt: txt/cord-268590-3e1tb64o.txt
summary:
  These numbers attest to the utility of the multilateral system and increased reliance upon it as a means of accessing genetic materials. The CWR project, with funding from the Norwegian government, provided financial and technical support for project partners to target and collect wild species related to crops, to create a safety back-up, and make collected material available through the multilateral system.


id: cord-315918-12rbbe8c
author: Mukherjee, Pulok K.
title: Antiviral Evaluation of Herbal Drugs
date: 2019-06-21
extension: .txt
mime: text/plain
words: 12824
sentence: 443
flesch: 39
cache: cache/cord-315918-12rbbe8c.txt
txt: txt/cord-315918-12rbbe8c.txt
summary:
  Many combinations of test viruses are possible, but a battery of six viruses seems to be quite acceptable. This assay is applicable for HIV-1, simian immunodeficiency virus (SIV), and simian-HIV and is carried out in TZM-bl cells as it reveal the reduction in Tat-induced luciferase (Luc) reporter gene expression after a single round of virus infection.


id: cord-348812-lufg9w7n
author: Schiavon, Michela
title: Selenium biofortification in the 21(st) century: status and challenges for healthy human nutrition
date: 2020-07-16
extension: .txt
mime: text/plain
words: 13055
sentence: 405
flesch: 27
cache: cache/cord-348812-lufg9w7n.txt
txt: txt/cord-348812-lufg9w7n.txt
summary:
  Irrigation may elevate Se in soil by either favoring dissolution of Se from minerals rich in Se or bringing Se loads to soil when Se-rich waters are used (Bajaj et al. 2011) , while adding Se to chemical fertilizers is a common practice when biofortification is conducted in Se deficient areas, where soil Se is below 0.6 mg kg − 1 , or when prevailing soil conditions hamper Se availability to plants (Gupta and Gupta 2000) . Future research addresses nanosized Se biofortification, crop enrichment with multiple micronutrients, microbial-integrated agronomic biofortification, and optimization of Se biofortification in adverse conditions.


id: cord-269992-ruf0vvz4
author: Sohrab, Sayed Sartaj
title: An edible vaccine development for coronavirus disease 2019: the concept
date: 2020-07-31
extension: .txt
mime: text/plain
words: 2005
sentence: 96
flesch: 48
cache: cache/cord-269992-ruf0vvz4.txt
txt: txt/cord-269992-ruf0vvz4.txt
summary:
  The concept of edible vaccine development has been presented in Fig. 1 . The oral administration of edible vaccines is a preferable route of vaccination for being a simple and safe route of administration; the low production cost allows for local production and minimal plant material processing; natural bio-encapsulation and hence, stability in the gastrointestinal (GI) tract; and protective immunogenicity at the GI mucosa.


id: cord-005205-z6bx0309
author: Herbers, Karin
date: 1995
extension: .txt
mime: text/plain
words: 5242
sentence: 230
flesch: 49
cache: cache/cord-005205-z6bx0309.txt
txt: txt/cord-005205-z6bx0309.txt
title:
  A simplified procedure for the subtractive cDNA cloning of photoassimilate-responding genes: isolation of cDNAs encoding a new class of pathogenesis-related proteins

summary:
  To avoid multiple cycles of subtraction with subsequent PCR amplification as developed by Straus and Ausubel for genomic subtraction [30] , the subtractive eDNA library was made by only one cycle of subtraction with subsequent selective cloning of transcripts from ppa-1 plants (Fig. 1 ). The eDNA library prepared from mRNA of ppa-1 plants was cut with the same restriction enzyme later used for establishment of the subtractive library.


id: cord-002282-ldfa616a
author: Joung, Young Hee
title: The Last Ten Years of Advancements in Plant-Derived Recombinant Vaccines against Hepatitis B
date: 2016-10-13
extension: .txt
mime: text/plain
words: 8150
sentence: 291
flesch: 32
cache: cache/cord-002282-ldfa616a.txt
txt: txt/cord-002282-ldfa616a.txt
summary:
  Edible plant vaccines are based on different parts of plants, such as fruits, seeds, and root vegetables. Among these platforms, the use of plant cells has received considerable attention in terms of intrinsic safety, scalability, and appropriate modification of target proteins.


id: cord-263470-vmqvropy
author: Rukavtsova, E. B.
date: 2007
extension: .txt
mime: text/plain
words: 2912
sentence: 126
flesch: 50
cache: cache/cord-263470-vmqvropy.txt
txt: txt/cord-263470-vmqvropy.txt
title:
  Tissue specific expression of hepatitis B virus surface antigen in transgenic plant cells and tissue culture

summary:
  Mechanical leaf wounding for induction of HBsAg gene expression. The immunoassay was carried out to study the expression profile of the surface antigen HBsAg in obtained plants.


id: cord-030028-s6sxi8uj
author: Rubio, Luis
title: Detection of Plant Viruses and Disease Management: Relevance of Genetic Diversity and Evolution
date: 2020-07-17
extension: .txt
mime: text/plain
words: 14694
sentence: 379
flesch: 22
cache: cache/cord-030028-s6sxi8uj.txt
txt: txt/cord-030028-s6sxi8uj.txt
summary:
  IF acknowledges financial support from the Spanish Ministerio de Economia y Competitividad, through the Severo Ochoa Programme for Centers of Excellence in R&D 2016-2019 (SEV-2015-0533). Detection and quantitation of two cucurbit criniviruses in mixed infection by real-time RT-PCR Mutations associated with resistancebreaking isolates of Beet necrotic yellow vein virus and their allelic discrimination using TaqMan technology Advances in plant virus evolution: translating evolutionary insights into better disease management Codon usage bias amongst plant viruses Virus adaptation by manipulation of host's gene expression Ecogenomic survey of plant viruses infecting tobacco by next generation sequencing Simultaneous detection and identification of Pepino mosaic virus (PepMV) isolates by multiplex one-step RT-PCR Genetic bottlenecks during systemic movement of Cucumber mosaic virus vary in different host plants Analysis of genetic bottlenecks during horizontal transmission of Cucumber mosaic virus Multiplex RT-PCR detection of three common viruses infecting orchids Rapid generation of genetic heterogeneity in progenies from individual cDNA clones of peach latent mosaic viroid in its natural host Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology drivers Control methods of virus diseases in the Mediterranean basin Simultaneous detection of six RNA plant viruses affecting tomato crops using a single digoxigenin-labelled polyprobe Development of a molecular assay for the detection of Cucumber mosaic virus and the discrimination of its subgroups I and II Detection of five seedborne legume viruses in one sensitive multiplex polymerase chain reaction test Single-step multiplex RT-PCR for simultaneous and colourimetric detection of six RNA viruses in olive trees Real-time RT-PCR high-resolution melting curve analysis and multiplex RT-PCR to detect and differentiate grapevine leafroll-associated virus 3 variant groups I, II, III and VI Estimation of the effective number of founders that initiate an infection after aphid transmission of a multipartite plant virus Localizing viruses in their insect vectors Third generation sequencing: technology and its potential impact on evolutionary biodiversity research Microarrays for rapid identification of plant viruses Methods in virus diagnostics: from ELISA to next generation sequencing Real time portable genome sequencing for global food security Epidemiology and control of tomato mosaic virus Nanopore sequencing as a surveillance tool for plant pathogens in plant and insect tissues Multiple virus resistance at a high frequency using a single transgene construct DNA microarray: parallel detection of potato viruses Design, synthesis, and functional analysis of highly specific artificial small RNAs with antiviral activity in plants Fast-forward generation of effective artificial small RNAs for enhanced antiviral defense in plants Multi-targeting of viral RNAs with synthetic trans-acting small interfering RNAs enhances plant antiviral resistance A real-time RT-PCR assay for quantifying the fitness of Tobacco etch virus in competition experiments Diagnosis of plant diseases using the Nanopore sequencing platform Development of broad virus resistance in non-transgenic cucumber using CRISPR/Cas9 technology Selection pressures in the capsid genes of plant RNA viruses reflect mode of transmission A phylogenetic survey of recombination frequency in plant RNA viruses Antibody array in a multiwell plate format for the sensitive and multiplexed detection of important plant pathogens Multiple virus resistance using artificial trans-acting siRNAs Next-generation diagnostics with CRISPR Characteristics of the microplate method of enzyme-linked immunosorbent assay for the detection of plant viruses The promiscuous evolutionary history of the family Bromoviridae NGS of virus-derived small RNAs as a diagnostic method used to determine viromes of Hungarian vineyards Lethal mutagenesis of an RNA plant virus via lethal defection Contribution of uneven distribution of genomic RNA variants of citrus tristeza virus (CTV) within the plant to changes in the viral population following aphid transmission A multiplex reverse transcription PCR assay for simultaneous detection of five tobacco viruses in tobacco plants Induction of silencing in plants by high-pressure spraying of in vitro-synthesized small RNAs Recombination profiles between Tomato yellow leaf curl virus and Tomato yellow leaf curl Sardinia virus in laboratory and field conditions: evolutionary and taxonomic implications Emergence and Phylodynamics of Citrus tristeza virus in Sicily, Italy Molecular detection of papaya meleira virus in the latex of carica papaya by RT-PCR Characterization of RNA-mediated resistance to tomato spotted wilt virus in transgenic tobacco plants Dominant resistance against plant viruses Detection, discrimination and absolute quantitation of Tomato spotted wilt virus isolates using real time RT-PCR with TaqMan ® MGB probes Transmission of Tomato spotted wilt virus isolates able and unable to overcome tomato or pepper resistance by its vector Frankliniella occidentalis Increase in Zucchini yellow mosaic virus symptom severity in tolerant zucchini cultivars is related to a point mutation in P3 protein and is associated with a loss of relative fitness on susceptible plants Differentiation of Cucumber mosaic virus isolates by hybridization to Rubio et al. genome move systemically and protect cucurbits against ZYMV Entomopathogenic viruses and bacteria for insect-pest control, in Integrated Pest Management: Current concepts and ecological perspective Nonparametric estimation from incomplete observations Plant virology and next generation sequencing: experiences with a potyvirus Screening for plant viruses by next generation sequencing using a modified double strand RNA extraction protocol with an internal amplification control Polycistronic artificial miRNA-mediated resistance to Wheat dwarf virus in barley is highly efficient at low temperature Current trends in diagnostics of viral infections of unknown etiology Lateral flow assays Population structure and genetic diversity within California Citrus tristeza virus (CTV) isolates The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses Complete viral genome sequence and discovery of novel viruses by deep sequencing of small RNAs: a generic method for diagnosis, discovery and sequencing of viruses MEGA X: molecular evolutionary genetics analysis across computing platforms Multiple artificial microRNAs targeting conserved motifs of the replicase gene confer robust transgenic resistance to negative-sense singlestranded RNA plant virus Tempo and mode of plant RNA virus escape from RNA interferencemediated resistance Improving the effectiveness of artificial microRNA (amiR)-mediated resistance against Turnip mosaic virus by combining two amiRs or by targeting highly conserved viral genomic regions Viruses of cucurbit crops in the Mediterranean region: an ever-changing picture Phylogenetic and recombination analysis of tomato spotted wilt virus Simultaneous detection of three lilyinfecting viruses using a multiplex Luminex bead array Genetic diversity and biological variation among California isolates of Cucumber mosaic virus Molecular evolution of a viral non-coding sequence under the selective Virus Variability: Diagnosis and Control pressure of amiRNA-mediated silencing Development of a one-step immunocapture real-time TaqMan RT-PCR assay for the broad spectrum detection of Pepino mosaic virus Effectiveness of chemo-and thermotherapeutic treatments on Pepino mosaic virus in tomato seed MicroRNA-mediated gene silencing in plant defense and viral counter-defense Development of real-time and conventional RT-PCR assays for the detection of potato yellow vein virus (PYVV)


id: cord-288673-ku3tmjd3
author: Sabotič, Jerica
title: Microbial and fungal protease inhibitors—current and potential applications
date: 2012-01-05
extension: .txt
mime: text/plain
words: 14637
sentence: 448
flesch: 17
cache: cache/cord-288673-ku3tmjd3.txt
txt: txt/cord-288673-ku3tmjd3.txt
summary:
  In medicine, protease inhibitors can be used as diagnostic or therapeutic agents for viral, bacterial, fungal and parasitic diseases as well as for treating cancer and immunological, neurodegenerative and cardiovascular diseases. Furthermore, protease inhibitors are indispensable in protein purification procedures to prevent undesired proteolysis during heterologous expression or protein extraction.


id: cord-016200-zfh20im0
author: Saxena, Jyoti
title: Edible Vaccines
date: 2013-10-22
extension: .txt
mime: text/plain
words: 7629
sentence: 364
flesch: 48
cache: cache/cord-016200-zfh20im0.txt
txt: txt/cord-016200-zfh20im0.txt
summary:
  Research in the field of edible vaccines holds immense potential for the future and every advancement made in this direction is bringing the dream of edible vaccine one step closer. Edible vaccines An edible vaccine for malaria using transgenic tomatoes of varying sizes, shapes and colors to carry different antigens Plant derived edible vaccines In vivo analysis of plastid psbA, rbcL and rpl32 UTR elements by chloroplast transformation: tobacco plastid gene expression is controlled by modulation of transcript levels and translation efficiency Control mechanisms of plastid gene expression Production of antibodies in transgenic plants Immunotherapeutic potential of antibodies produced in plants Production of biologically active human interleukin-4 in transgenic tomato and potato Transgenic plants as vaccine production systems Expression of hepatitis B surface antigen in transgenic plants Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine Edible vaccines: a concept comes of age Plant biotechnology and in vitro biology in the 21st century Production of hepatitis B surface antigen in transgenic plants for oral immunization Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes Immunogenicity in humans of an edible vaccine for hepatitis B Oral immunization with a combination of Plasmodium yoelii merozoite surface protein 1 and 4/5 enhances protection against lethal malarial challenge


id: cord-016425-8yd2bkf1
author: Strobel, Gary
title: Novel Natural Products From Rainforest Endophytes
date: 2005
extension: .txt
mime: text/plain
words: 9005
sentence: 390
flesch: 40
cache: cache/cord-016425-8yd2bkf1.txt
txt: txt/cord-016425-8yd2bkf1.txt
summary:
  Cryptocandin is also active against a number of plant pathogenic fungi, including Sclerotinia sclerotiorum and Botrytis cinerea. Pestalotiopsis jesteri is a newly described endophytic fungal species from the Sepik River area of Papua New Guinea, and it produces jesterone and hydroxyjesterone, which exhibit antifungal activity against a variety of plant pathogenic fungi (30) .


id: cord-005145-1l87fdmi
author: Marquet-Blouin, E.
date: 2003
extension: .txt
mime: text/plain
words: 5652
sentence: 206
flesch: 42
cache: cache/cord-005145-1l87fdmi.txt
txt: txt/cord-005145-1l87fdmi.txt
title:
  Neutralizing immunogenicity of transgenic carrot (Daucus carota L.)-derived measles virus hemagglutinin

summary:
  Efficacy of a food plant based cholera toxin B subunit vaccine A plant-based cholera toxin B subunit-insulin fusion protein protects against the development of autoimmune diabetes Analysis of the N-glycosylation of recombinant glycoproteins produced in transgenic plants Binary Agrobacterium vectors for plant transformation Immunosorbent assay based on recombinant hemagglutinin protein produced in a high-efficiency mammalian expression system for surveillance of measles immunity A simplified immunoassay based on measles virus recombinant hemagglutinin protein for testing the immune status of vaccinees Transgenic plants as a potential source of an oral vaccine against Helicobacter pylori Oral immunization by transgenic plants Protective immune response to foot-and-mouth disease virus with VP1 expressed in transgenic plants Measles virus fusion protein-and hemagglutinin-transfected cell lines are sensitive tool for the detection of specific antibodies by FACS-measured immunofluorescence assay Enhanced antigenicity of a four-contact-residue epitope of the measles virus hemagglutinin protein by phage display libraries: evidence of a helical structure in the putative active site Detection, biosynthesis and some functions of glycans N-linked to plant secreted proteins A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity Antibodies to a new linear site at the topographical or functional interface between the haemagglutinin and fusion proteins protect against measles encephalitis Correlation between epitopes on hemagglutinin of measles virus and biological activities: passive protection by monoclonal antibodies is related to their hemagglutination inhibiting activity Expression of immunogenic glycoprotein S polypeptides from transmissible gastroenteritis coronavirus in transgenic plants Oral immunization with a recombinant bacterial antigen produced in transgenic plants Transformation and regeneration of carrot Foreign gene expression in plants Role of individual cysteine residues in the processing and antigenicity of measles virus hemagglutinin protein Role of N-linked oligosaccharide chains in the processing and the antigenicity of the measles virus haemagglutinin protein Plant-derived measles virus hemagglutinin protein induces neutralizing antibodies in mice Preparation of RNA from cotton leaves and pollen A plant-derived edible vaccine against hepatitis B virus Oral immunization with hepatitis B surface antigen expressed in transgenic plants Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretary IgA antibodies Expression of hepatitis B surface antigen in transgenic plants Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice Monospecific antibody to the haemagglutinin of measles virus Expression of the rabies virus glycoprotein in transgenic tomatoes Antibodies to measles, mumps, and rubella in UK children 4 years after vaccination with different MMR vaccines Immunization against rabies with plant-derived antigen Modeling the impact of subclinical measles transmission in vaccinated populations with waning immunity Cholera toxin B stimulates systemic neutralizing antibodies after intranasal co-immunization with measles virus Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus Identification of DNA sequences required for activity of a plant promoter: the CaMV 35S promoter Expression in plants of two bacterial antibiotic resistance genes after protoplast transformation with a new plant expression vector Nuclear transport of plant potyviral proteins Production of hepatitis B surface antigen in transgenic plants for oral immunization Oral immunization in mice with transgenic tomato fruit expressing respiratory syncytial virus-F protein induces a systemic immune response Promoters for pregenomic RNA of banana streak badnavirus are active for transgene expression in monocot and dicot plants Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes Immunogenicity of transgenic plant-derived hepatitis B surface antigen A rapid method for transformation of carrot (Daucus carota L.) by using direct somatic embryogenesis Synthesis of the membrane fusion and hemagglutinin proteins of measles virus, using a novel baculovirus vector containing the β-galactosidase gene Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parental immunization with alfalfa transgenic plants expressing the viral structural protein VP1 Measles virus: both hemagglutinin and fusion glycoproteins are requiered for fusion Protection against measles virus encephalitis by monoclonal antibodies binding to a cystein loop domain of the H protein mimicked by peptides which are not recognized by maternal antibodies We are grateful to Richard Wagner and his team (IBMP) for taking care of the transgenic carrots. These results demonstrate that transgenic carrot plants can be used as an efficient expression system to produce highly immunogenic viral antigens.


id: cord-031957-df4luh5v
author: dos Santos-Silva, Carlos André
date: 2020-09-02
extension: .txt
mime: text/plain
words: 16639
sentence: 632
flesch: 34
cache: cache/cord-031957-df4luh5v.txt
txt: txt/cord-031957-df4luh5v.txt
title:
  Plant Antimicrobial Peptides: State of the Art, In Silico Prediction and Perspectives in the Omics Era

summary:
  Thus, there is a need for computational framework methods to predict protein structures based on the knowledge of the sequence. In addition, in recent years, there has been impressive progress in the development of algorithms for protein folding that may aid in the prediction of protein structures from amino acid sequence information.


id: cord-340497-8l3gw6sk
author: Avgoustaki, Dafni Despoina
date: 2020-09-25
extension: .txt
mime: text/plain
words: 18680
sentence: 636
flesch: 40
cache: cache/cord-340497-8l3gw6sk.txt
txt: txt/cord-340497-8l3gw6sk.txt
title:
  How energy innovation in indoor vertical farming can improve food security, sustainability, and food safety?

summary:
  To summarize some of the basic improvements in resource savings provided by indoor vertical farms compared to the immediately following high technology cultivation system, the greenhouses are the following: • Indoor vertical farms save 100% of the pesticide use in their interior by maintaining the culture area clean and insect-free. Indoor vertical farms can produce high quality and virus-free products that can be locally distributed, inside the urban environment that such investments take place, saving annually millions of tons CO2 emissions.


id: cord-016268-xcx1c0da
author: Sahai, Aastha
title: Plant Edible Vaccines: A Revolution in Vaccination
date: 2013-04-15
extension: .txt
mime: text/plain
words: 11303
sentence: 415
flesch: 39
cache: cache/cord-016268-xcx1c0da.txt
txt: txt/cord-016268-xcx1c0da.txt
summary:
  These results suggest a new strategy for the development of plant vaccines. Protein Expression and Purifi cation A plant-derived vaccine against hepatitis B virus Plant based HIV-1 vaccine candidate: Tat protein produced in spinach Synthesis and assembly of anthrax lethal factor cholera toxin B-subunit fusion protein in transgenic potato Current trends in edible vaccine development using transgenic plants Oral immunization with hepatitis B surface antigen expressed in transgenic plants The green revolution: Plants as heterologous expression vectors Foods as production and delivery vehicles for human vaccines Expression of hepatitis B surface antigen in transgenic banana plants Edible vaccines: Current status and future Edible vaccines Accumulation of trehalose within transgenic chloroplasts confers drought tolerance Chloroplast expression of His-tagged GUS-fusions: A general strategy to overproduce and purify foreign proteins using transplastomic plants as bioreactors N-glycoprotein biosynthesis in plants: Recent developments and future trends Pharming and transgenic plants Eukaryotic viral expression systems for polypeptides Development of an edible rabies vaccine in maize using the Vnukovo strain Auto antigens produced in plants for oral tolerance therapy of autoimmune diseases Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4 Antibody processing and engineering in plants, and new strategies for vaccine production Optimization of human papillomavirus type 16 (HPV-16) L1 expression in plants: Comparison of the suitability of different HPV-16 L1 gene variants and different cell-compartment localization Production of edible vaccines for oral immunization in transgenic plants, current and future prospective Recent advances in plant derived vaccine antigens against human infectious diseases Edible vaccine-vegetables as alternative to needles Transgenic plants as vaccine production systems Expression of hepatitis B surface antigen in transgenic plants Expression of Norwalk virus capsid protein in transgenic tobacco and protein and its oral immunogenicity in mice Edible vaccine protects mice against E. coli heat-labile enterotoxin (LT): Potatoes expressing a synthetic LT-B gene Multiple presentation of foreign peptides on the surface of an RNA-free bacteriophage capsid Generation of transgenic banana ( Musa acuminata ) plants via Agrobacterium -mediated transformation Rapid production of specifi c vaccines for lymphoma by expression of tumor-derived single-chain Fv epitopes in tobacco plants Expression of the rabies virus glycoprotein in transgenic tomatoes Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans Edible vaccines:


id: cord-290088-g9559ux3
author: Loh, Hwei-San
date: 2017-08-08
extension: .txt
mime: text/plain
words: 2853
sentence: 89
flesch: 26
cache: cache/cord-290088-g9559ux3.txt
txt: txt/cord-290088-g9559ux3.txt
title:
  Using transgenic plants and modified plant viruses for the development of treatments for human diseases

summary:
  The initial strategy involved production of recombinant proteins using plant viruses by exploiting their natural ability to infect (full virus) plants. In addition to offering a versatile production platform for numerous plant-made proteins, plant viruses have been engineered to provide medical applications in other ways [22] .


id: cord-103255-4k13re9y
author: Daniell, Henry
date: 2001-05-01
extension: .txt
mime: text/plain
words: 4362
sentence: 174
flesch: 38
cache: cache/cord-103255-4k13re9y.txt
txt: txt/cord-103255-4k13re9y.txt
title:
  Medical molecular farming: production of antibodies, biopharmaceuticals and edible vaccines in plants

summary:
  As with antibodies, transient expression systems (in which candidate vaccine sequences are incorporated into plant viral surface proteins) have also been investigated extensively and high levels of expression have been achieved. There has been no evidence of allergic reaction or of a human antimouse antibody (HAMA) response in 60 patients receiving topical oral application of a secretory IgA specific to S. mutans 8 . Proteins of microbial and viral pathogens were some of the earliest examples chosen to show the feasibility of transgenic plant expression systems 14-17 .


id: cord-016341-7obr779b
author: Prasad, R.
title: Interactions of Piriformospora indica with Medicinal Plants
date: 2008
extension: .txt
mime: text/plain
words: 7644
sentence: 303
flesch: 38
cache: cache/cord-016341-7obr779b.txt
txt: txt/cord-016341-7obr779b.txt
summary:
  Isolation of metabolites of interest in rheumatoid arthritis, immunosuppression, and male contraceptive activity The biology of myco-hetrotrophic (saprophytic) plants Anti-fertility effects of aqueous extracts of Carica papaya seeds in male rats Phosphorus solubilizing symbiotic fungus: Piriformospra indica Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis Traditional knowledge, herbal remedies to anti bacterial therapy: its current status in the 21st century Comparison of Metabolic effects of ethanolic extracts of Ancistrophyllum secundiflorum and menstrogen (orthodox contraceptive) on metabolic parameters in pregnant rabbits MATH-domain proteins represent a novel protein family in Arabidopsis thaliana and at least one member is modified in roots in the course of a plant/microbe interaction Association of Piriformospora indica with Arabidopsis thaliana roots represent a novel system to study beneficial plant-microbe interactions and involve in early plant protein modifications in the endocytoplasmic reticulum and in the plasma membrane Interaction of Piriformospora indica with diverse microorganisms and plants Axenic cultures of Piriformospora indica Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species Interaction of medicinal plants with plant growth promoting rhizobacteria and symbiotic fungi Sebacinaceae: culturable mycorrhiza-like endosymbiotic fungi and their interaction with non-transformed and transformed roots. The most common and prevalent arbuscular mycorrhizal fungi play an indispensable role in upgrading plant growth, vigor and survival by a positive impact on the nutritional and hydratic status of the plant and on soil health, by increasing the reproductive potential, improving root performance, and providing a natural defence against invaders, including pests and pathogens.


id: cord-307607-8xn9jtmh
author: Sargin, Seyid Ahmet
title: Potential anti-influenza effective plants used in Turkish folk medicine: A review
date: 2020-08-31
extension: .txt
mime: text/plain
words: 7074
sentence: 267
flesch: 43
cache: cache/cord-307607-8xn9jtmh.txt
txt: txt/cord-307607-8xn9jtmh.txt
summary:
  In this context, approximately 700 articles conducted between January 1977 and February 2020 throughout Turkey were excluded since they did not meet the inclusion criteria and a consensus has been provided among the 81 works on the determination of medicinal plants used by local people for centuries. Besides, it can never be ignored that medicinal plants are very successful in preventing and treating influenza if used according to the prescriptions specified in their pharmacopoeia.


id: cord-018428-6lc1fcpe
author: Rekha, Kaliyaperumal
title: Secondary Metabolite Production in Transgenic Hairy Root Cultures of Cucurbits
date: 2017-01-18
extension: .txt
mime: text/plain
words: 9051
sentence: 442
flesch: 42
cache: cache/cord-018428-6lc1fcpe.txt
txt: txt/cord-018428-6lc1fcpe.txt
summary:
  Hairy root cultures offer promise for high production and productivity of valuable secondary metabolites in many plants. To this end, hairy root culture presents an excellent platform for producing valuable secondary metabolites.


id: cord-333518-67md81fq
author: Sofo, Adriano
date: 2020-04-22
extension: .txt
mime: text/plain
words: 3748
sentence: 150
flesch: 54
cache: cache/cord-333518-67md81fq.txt
txt: txt/cord-333518-67md81fq.txt
title:
  Converting Home Spaces Into Food Gardens At the Time of Covid-19 Quarantine: All the Benefits of Plants in This Difficult and Unprecedented Period

summary:
  Home vegetable gardens could provide a small-scale approach to the sustainable use of natural resources, leading towards self-sufficiency, self-regulation, sustainability, and environmental protection. Regardless of practical challenges and the existential difficulties we face, there is untapped potential for home vegetable gardens to influence environmental outcomes, citizens' consciousness, and market trends.


id: cord-018018-2yyv8vuy
author: Rybicki, Ed
title: History and Promise of Plant-Made Vaccines for Animals
date: 2018-07-04
extension: .txt
mime: text/plain
words: 9139
sentence: 182
flesch: 16
cache: cache/cord-018018-2yyv8vuy.txt
txt: txt/cord-018018-2yyv8vuy.txt
summary:
  The early historical account of molecular farming for veterinary vaccines given above gives an idea of the array of technologies available and used up to the mid-2000s: transgenic and transplastomic expression of subunit proteins; recombinant plant viruses either used to express whole vaccine candidate genes, or to display chosen peptides fused to their capsid proteins; fusion of vaccine protein genes to carrier proteins to improve immunogenicity, including by inherent adjuvant properties; candidate parenteral and oral vaccines to both viruses and bacteria; therapeutics for animals made in plants; use of plant cell cultures to make antigens. The case for plant-made veterinary immunotherapeutics Protein body induction: a new tool to produce and recover recombinant proteins in plants Optimizing the yield of recombinant pharmaceutical proteins in plants New viral vector for superproduction of epitopes of vaccine proteins in plants Expression of an animal virus antigenic site on the surface of a plant virus particle Expression of Human papillomavirus type 16 major capsid protein in transgenic Nicotiana tabacum cv Optimization of BY-2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection Oral immunogenicity of human papillomavirus-like particles expressed in potato Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1 Protection of mice against challenge with foot and mouth disease virus (FMDV) by immunization with foliar extracts from plants infected with recombinant tobacco mosaic virus expressing the FMDV structural protein VP1 Protective lactogenic immunity conferred by an edible peptide vaccine to bovine rotavirus produced in transgenic plants One-Health: a safe, efficient, dual-use vaccine for humans and animals against middle east respiratory syndrome coronavirus and rabies virus Induction of protective immunity in swine by recombinant bamboo mosaic virus expressing foot-and-mouth disease virus epitopes Expression of the fusion glycoprotein of Newcastle disease virus in transgenic rice and its immunogenicity in mice A plant-based multicomponent vaccine protects mice from enteric diseases Expression in plants and immunogenicity of plant virus-based experimental rabies vaccine Development of a candidate vaccine for Newcastle disease virus by epitope display in the Cucumber mosaic virus capsid protein


id: cord-346053-mk1mzc5z
author: Morris, Cindy E.
date: 2009-12-24
extension: .txt
mime: text/plain
words: 4760
sentence: 189
flesch: 32
cache: cache/cord-346053-mk1mzc5z.txt
txt: txt/cord-346053-mk1mzc5z.txt
title:
  Expanding the Paradigms of Plant Pathogen Life History and Evolution of Parasitic Fitness beyond Agricultural Boundaries

summary:
  In contrast, the evolution of virulence in plant pathogens has been investigated from a predominantly agro-centric perspective, and has focused overwhelmingly on evolutionary forces related to interactions with the primary plant host. Here, we argue that current concepts from the field of medical epidemiology regarding mechanisms that lead to acquisition of novel virulence, biocide resistance, and enhanced pathogenic fitness can serve as an important foundation for novel hypotheses about the evolution of plant pathogens.


id: cord-016575-bn15006x
author: Cox-Georgian, Destinney
title: Therapeutic and Medicinal Uses of Terpenes
date: 2019-11-12
extension: .txt
mime: text/plain
words: 9861
sentence: 411
flesch: 46
cache: cache/cord-016575-bn15006x.txt
txt: txt/cord-016575-bn15006x.txt
summary:
  This was studied by Astani et al. Cannabis is one of the most common sources for the medicinal terpene (Franklin et al. 2001 ).


id: cord-017419-yrw4wrxj
author: Mugford, Sam T.
title: Saponin Synthesis and Function
date: 2012-08-22
extension: .txt
mime: text/plain
words: 10227
sentence: 346
flesch: 37
cache: cache/cord-017419-yrw4wrxj.txt
txt: txt/cord-017419-yrw4wrxj.txt
summary:
  Yoshikawa et al. , 1997 Yoshikawa et al. , 2000 Yoshikawa et al. , 2005 Germonprez et al. 2004 ; Zou et al. 2005 ) . Yoshikawa et al. , 1997 Yoshikawa et al. , 2000 Yoshikawa M et al. 2005 ; Germonprez et al. 2004 ; Zou et al. 2005 ) .


id: cord-309052-3h0g7s9v
author: Alam, Fiaz
title: Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: A review
date: 2017-12-15
extension: .txt
mime: text/plain
words: 9688
sentence: 365
flesch: 36
cache: cache/cord-309052-3h0g7s9v.txt
txt: txt/cord-309052-3h0g7s9v.txt
summary:
  Missouri Botanical Garden and University of Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1) DNA polymerase and topoisomerase II inhibitors from Psoralea c orylifolia Gonadal toxicity of an ethanol extract of Psoralea corylifolia in a rat 90-day repeated dose study Psoralen stimulates osteoblast differentiation through activation of BMP signaling Review article: Herbal hepatotoxicity-an update on traditional Chinese medicine preparations New constituents from Psoralea corylifolia Histone deacetylase inhibitor sodium butyrate enhances the cell killing effect of psoralen plus UVA by attenuating nucleotide excision repair Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats Screening south Indian medicinal plants for antifungal activity against cutaneous pathogens Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids Chemical constituents from Psoralea corylifolia and their antioxidant alphaglucosidase inhibitory and antimicrobial activities. The low polarity ether extract of P. corylifolia seeds was investigated, and it revealed the presence of various ketones and aldehydes containing compounds such as Corylinal, C-formylated chalcone, and Isoneobayachalcone.


id: cord-024149-qnclsjym
author: Gupta, Ankit
title: Microbes and Environment
date: 2016-10-15
extension: .txt
mime: text/plain
words: 11676
sentence: 568
flesch: 37
cache: cache/cord-024149-qnclsjym.txt
txt: txt/cord-024149-qnclsjym.txt
summary:
  One of the best nature's strategies for bioremediation is the catechol dioxygenase found in soil bacteria which is involved in transformation and degradation of aromatic molecules into aliphatic products. Hartig net is a soil network that connects several organisms and protects against pathogenic fungi and soil bacteria.


id: cord-306733-df36w6l7
author: Rosales-Mendoza, Sergio
title: What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?
date: 2020-04-14
extension: .txt
mime: text/plain
words: 8607
sentence: 332
flesch: 34
cache: cache/cord-306733-df36w6l7.txt
txt: txt/cord-306733-df36w6l7.txt
summary:
  Another approach to express heterologous protein in plants relies on the use of viral-based vectors, which exploit the efficient promoters, UTRs, and DNA/RNA replication mechanisms found in plant viruses. A recent review revealed that at least 97 vaccine candidates have been developed based on plant viruses covering infectious agents, cancer, and autoimmune disorders [78] .


id: cord-021013-xvc791wx
author: Wink, Michael
title: Chapter 1 Allelochemical Properties or the Raison D'être of Alkaloids
date: 2008-05-30
extension: .txt
mime: text/plain
words: 16169
sentence: 734
flesch: 45
cache: cache/cord-021013-xvc791wx.txt
txt: txt/cord-021013-xvc791wx.txt
summary:
  In a number of plants alkaloids are translocated via the phloem (511). The ingestion of a number of allelochemicals such as emetine, lobeline, morphine, and many other alkaloids causes these symptoms (312).


id: cord-032371-qwqf3rlf
author: Labudda, Mateusz
date: 2020-09-21
extension: .txt
mime: text/plain
words: 12059
sentence: 462
flesch: 46
cache: cache/cord-032371-qwqf3rlf.txt
txt: txt/cord-032371-qwqf3rlf.txt
title:
  Reactive oxygen species metabolism and photosynthetic performance in leaves of Hordeum vulgare plants co-infested with Heterodera filipjevi and Aceria tosichella

summary:
  However, the DHAR activity was increased in N + WCM plants (about 25%) in comparison with WCM plants (Fig. 2g) . The highest activity of ARG was observed in WCM plants (about 6 µmol h −1 g −1 ) and the lowest (about 4 µmol h −1 g −1 ) in N + WCM plants.


id: cord-018647-bveks6t1
author: Butnariu, Monica
title: Plant Nanobionics: Application of Nanobiosensors in Plant Biology
date: 2019-10-01
extension: .txt
mime: text/plain
words: 16819
sentence: 684
flesch: 37
cache: cache/cord-018647-bveks6t1.txt
txt: txt/cord-018647-bveks6t1.txt
summary:
  A series of new genes for resistance to insect attack, transferable to plants (genes encoding δ-endotoxin production from B. thuringiensis) has been discovered; genes for the synthesis of enzymes or enzyme inhibitors; plant genes encoding the synthesis of specific lectins; genes that cause induction of synthesis of plant compounds such as phytoalexins. Given the practical significance of plant resistance to harmful insects, research has been extended to other plant species, producing eggplant plants resistant to the attack of Coleoptera, broccoli with resistance to certain lepidopteran species, maize with resistance to B. fusca, etc., as well as a number of advances in leguminous plants.


id: cord-324335-eoabmyg7
author: Nicoletti, Marcello
title: New solutions using natural products
date: 2020-08-21
extension: .txt
mime: text/plain
words: 31242
sentence: 1232
flesch: 42
cache: cache/cord-324335-eoabmyg7.txt
txt: txt/cord-324335-eoabmyg7.txt
summary:
  Other studies on resistance mechanisms of Plasmodium are enabling new possible methods of control always based on natural products activity. and biotic targets, which are important to the individual homeostasis and survival. key: cord-324335-eoabmyg7 authors: Nicoletti, Marcello title: New solutions using natural products date: 2020-08-21 journal: Insect-Borne Diseases in the 21st Century DOI: 10.1016/b978-0-12-818706-7.00007-3 sha: doc_id: 324335 cord_uid: eoabmyg7 Most antibiotics are derived from natural products, like penicillin, as well as recent insecticides, like pyrethroids.


id: cord-016293-pyb00pt5
author: Newell-McGloughlin, Martina
title: The flowering of the age of Biotechnology 1990–2000
date: 2006
extension: .txt
mime: text/plain
words: 22413
sentence: 857
flesch: 45
cache: cache/cord-016293-pyb00pt5.txt
txt: txt/cord-016293-pyb00pt5.txt
summary:
  These DNA chips have broad commercial applications and are now used in many areas of basic and clinical research including the detection of drug resistance mutations in infectious organisms, direct DNA sequence comparison of large segments of the human genome, the monitoring of multiple human genes for disease associated mutations, the quantitative and parallel measurement of mRNA expression for thousands of human genes, and the physical and genetic mapping of genomes. Of course for such a radical approach certain basal level criteria needed to be established for selecting disease candidates for human gene therapy.


id: cord-024652-4i6kktl0
author: Santra, Hiran Kanti
title: Natural Products as Fungicide and Their Role in Crop Protection
date: 2020-05-12
extension: .txt
mime: text/plain
words: 20776
sentence: 641
flesch: 25
cache: cache/cord-024652-4i6kktl0.txt
txt: txt/cord-024652-4i6kktl0.txt
summary:
  to echinocandin LY303366, itraconazole and amphotericin B Biochemical defense mechanisms in cotton plants against Ramularia leaf spot mediated by silicon In vitro antifungal activity of 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate, a dihydro -pyrrole derivative Phytoalexin accumulation in tissues of Brassica napus inoculated with Leptosphaeria maculans Naphthalene, an insect repellent, is produced by Muscodor vitigenus, a novel endophytic fungus Activities of essential oils from Asarum heterotropoides var. mandshuricum against five phytopathogens Antagonist actinomycetes metabolites against plant pathogens fungi of agricultural importance Induction of phytoalexins and proteins related to pathogenesis in plants treated with extracts of cutaneous secretions of southern Amazonian Bufonidae amphibians Natural products in crop protection Bioassay-guided isolation of allelochemicals from Avena sativa L.: allelopathic potential of flavone C-glycosides Antifungal activity of crude extracts from brown and red seaweeds by a supercritical carbon dioxide technique against fruit postharvest fungal diseases Rhizospheric streptomycetes as potential biocontrol agents of Fusarium and Armillaria pine rot and as PGPR for Pinus taeda Geldanamycin, a new antibiotic Induction of Fusarium solani mutants insensitive to tomatine, their pathogenicity and aggressiveness to tomato fruits and pea plants Molecular engineering of resveratrol in plants Antifungal properties of surangin B, a coumarin from Mammea longifolia Phytochemical analysis and antifungal activity of moss Bryum cellulare against some phytopathological fungi Studies on antifungal potential of Bryum cellulare against spore germination of fungus Curvularia lunata In vitro antifungal activity of Plagiochasma appendiculatum against Alternaria solani Evaluation of bryophyte for green fungicides as alternative treatment to control plant pathogen Oxidative ring contraction of the phytoalexin cyclobrassinin: a way to brassilexin Brassilexin, a novel sulphur-containing phytoalexin from Brassica juncea L., (cruciferae) Nees against sporulation and growth of postharvest phytopathogenic fungi Evaluation of Streptomyces griseorubens E44G for the biocontrol of Fusarium oxysporum f. sp. lycopersici: ultrastructural and cytochemical investigations Interactions between a root-knot nematode (Meloidogyne exigua) and arbuscular mycorrhizae in coffee plant development (Coffea arabica) Foliar epicuticular wax of Arrabidaea brachypoda: flavonoids and antifungal activity Metabolites of Helminthosporium monoceras: structures of monocerin and related benzopyrans Trans-trans-3, 11-tridecadiene5, 7, 9-triyne-1,2-diol, an antifungal polyacetylene from diseased safflower (Carthamus tinctorius) Mycofumigation by the volatile organic compound-producing fungus Muscodor albus induces bacterial cell death through DNA damage Mycorrhizal fungi and Trichoderma harzianum as biocontrol agents for suppression of Rhizoctonia solani damping off disease of tomato Effect of volatile metabolites of Trichoderma species against seven fungal plant pathogens in vitro Production of gliotoxin on natural substrates by Trichoderma virens Studies on antagonistic effect against plant pathogenic fungi from endophytic fungi isolated from Houttuynia cordata Thunb.


id: cord-014462-11ggaqf1
date: 2011-04-21
extension: .txt
mime: text/plain
words: 35463
sentence: 1572
flesch: 47
cache: cache/cord-014462-11ggaqf1.txt
txt: txt/cord-014462-11ggaqf1.txt
title:
  Abstracts of the Papers Presented in the XIX National Conference of Indian Virological Society, “Recent Trends in Viral Disease Problems and Management”, on 18–20 March, 2010, at S.V. University, Tirupati, Andhra Pradesh

summary:
  The following virus isolates have been used in the analysis: GTPV-Uttarkashi, P60, vaccine virus; GTPV Mukteswar, P10, Challenge virus; GTPV (Akola), GTPV Bareilly/00, GTPV Ladakh/01 and GTPV Sambalpur/82, field isolates and SPPV Srinagar, P40; SPPV Ranipet, P50; SPPV-RF, P50, vaccine viruses and SPPV Makdhoom/07, SPPV CIRG/08, SPPV Pune/08, SPPV Bareilly, SPPV 183/03 and SPPV 125/02, field isolates. Present paper discusses about virus disease of quarantine importance affecting ornamental and fruit plants such as Chrysanthimum, Dahlia, Dianthus, Rosabengalensis, Cattleya, Cymbidium, Dendrobium, Lilium, Citrus, Vitis etc.


id: cord-022889-lv6fy6e6
author: Dávalos, Alberto
date: 2019-08-07
extension: .txt
mime: text/plain
words: 96106
sentence: 3710
flesch: 44
cache: cache/cord-022889-lv6fy6e6.txt
txt: txt/cord-022889-lv6fy6e6.txt
title:
  Literature review of baseline information on non‐coding RNA (ncRNA) to support the risk assessment of ncRNA‐based genetically modified plants for food and feed

summary:
  In a later observational study, Lukasik et al. evaluated plant miRNAs miR-166a, miR-156a, miR-157a, miR-172a and miR-168a and reported the presence of plant miRNAs in human (n=6) breast milk, both in whole milk and exosomes . This HEN1-dependent 2'-Omethylation on the 3' terminal ribose is a Mg2+ dependent methylation mechanism that will ultimately stabilize miRNAs (Abe et al., 2010; Molnar et al., 2007; Yu et al., 2005; Yang et al., 2006) .The


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id: cord-022889-lv6fy6e6
domain: www.foodstandards.gov.au
url:
  http://www.foodstandards.gov.au/consumer/gmfood/pages/response-to-heinemann-et-al-on-theregulation-of-gm-crops-and-foods-developed-using-gene-silencing.aspx)


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  aislamiento y caracterización de las lectinas de leguminosas silvestres del desierto de sonora: cercidium praecox (palo de brea


id: cord-005145-1l87fdmi
sid: 207
eid: 1
type: ORG
entity:
  the ministère de l'education nationale et de la formation professionnelle du grand-duché de luxembourg


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