item: #1 of 68 id: cord-000254-bufbjdmw author: Clement, Annick title: Interstitial lung diseases in children date: 2010-08-20 words: 15055 flesch: 31 summary: The diagnostic value of bronchoalveolar lavage in immunocompetent children with chronic diffuse pulmonary infiltrates The safety and efficacy of thoracoscopic lung biopsy for diagnosis and treatment in infants and children Diagnosis of interstitial lung disease by a percutaneous lung biopsy sample Combined percutaneous lung biopsy and high-resolution computed tomography in the diagnosis and management of lung disease in children key: cord-000254-bufbjdmw authors: Clement, Annick; Nathan, Nadia; Epaud, Ralph; Fauroux, Brigitte; Corvol, Harriet title: Interstitial lung diseases in children date: 2010-08-20 journal: keywords: alveolar; biopsy; cases; cells; children; chronic; development; diagnosis; diffuse; disease; disorders; fibrosis; function; ild; interstitial; lung; lung disease; patients; pediatric; presence; protein; pulmonary; specific; surfactant; symptoms; syndrome; tissue; virus cache: cord-000254-bufbjdmw.txt plain text: cord-000254-bufbjdmw.txt item: #2 of 68 id: cord-000268-480d3yfv author: Porfyridis, Ilias title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 words: 4277 flesch: 39 summary: Imaging of pneumonia: trends and algorithms Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia TREM-1(triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses TREM-1 amplifies inflammation and is a crucial mediator of septic shock Does soluble triggering receptor expressed on myeloid cells-1 play any role in the pathogenesis of septic shock? Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes Clinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsis Triggering receptor expressed on myeloid cells-1 (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients Soluble triggering receptor expressed on myeloid cells-1: a biomarker for bacterial meningitis Increased levels of soluble triggering receptor expressed on myeloid cells-1 in patients with acute pancreatitis Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis Soluble triggering receptor expressed on myeloid cells-1(sTREM-1): a new mediator involved in the pathogenesis of peptic ulcer disease Role of soluble triggering receptor expressed on myeloid cells-1 in inflammatory bowel disease TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer Activation of triggering receptor expressed on myeloid cells-1 on human neutrophils by Marburg and ebola viruses Soluble triggering receptor expressed on myeloid cells 1 is released in patients with stable chronic obstructive pulmonary disease Increased plasma levels of soluble triggering receptor expressed on myeloid cells 1 and procalcitonin after cardiac surgery and cardiac arrest without infection The increased expression of TREM-1 on monocytes is associated with infectious and non-infectious inflammatory processes Soluble TREM-1 is not suitable for distinguishing between systemic inflammatory response syndrome and sepsis survivors and nonsurvivors in the early stage of acute inflammation Prognosis of community acquired pneumonia(CAP): value of triggering receptor expressed on myeloid cells-1 (TREM-1) and other mediators of the inflammatory response Timecourse of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis Diagnosing pneumonia during mechanical ventilation: the clinical pulmonary infection score revisited Infectious Diseases Society of America Guidelines for the management of adult lower respiratory track infections Acute pulmonary embolism focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of chronic heart failure in adults: A Report of the American College of Cardiology Foundation European Respiratory Society international multidisciplinary consensus classification of idiopathic interstitial pneumonias Early changes of CD4-positive lymphocytes and NK cells in patients with severe Gram-negative sepsis The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome TREM and TREM-like receptors in inflammation and disease The TREM receptor family and signal integration Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells -1(sTREM-1) in the septic host Soluble triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis Soluble triggering receptor expressed on myeloid cells-1 as an antiinflammatory mediator in sepsis Soluble triggering receptor expressed on myeloid cells -1 key: cord-000268-480d3yfv authors: Porfyridis, Ilias; Plachouras, Diamantis; Karagianni, Vasiliki; Kotanidou, Anastasia; Papiris, Spyridon A; Giamarellou, Helen; Giamarellos-Bourboulis, Evangelos J title: Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study date: 2010-09-29 journal: BMC Infect Dis DOI: 10.1186/1471-2334-10-286 sha: doc_id: 268 cord_uid: 480d3yfv BACKGROUND: Differential diagnosis of patients with lung infiltrates remains a challenge. keywords: group; infiltrate; lung; myeloid; patients; pulmonary; receptor; strem-1; study cache: cord-000268-480d3yfv.txt plain text: cord-000268-480d3yfv.txt item: #3 of 68 id: cord-000364-ikq38rm1 author: Rasmuson, J. title: Time to revise the paradigm of hantavirus syndromes? Hantavirus pulmonary syndrome caused by European hantavirus date: 2011-01-15 words: 2843 flesch: 39 summary: Hantavirus pulmonary syndrome caused by European hantavirus date: 2011-01-15 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-010-1141-6 sha: doc_id: 364 cord_uid: ikq38rm1 Hantaviruses have previously been recognised to cause two separate syndromes: hemorrhagic fever with renal syndrome in Eurasia, and hantavirus pulmonary syndrome (HPS) in the Americas. Pathogenesis of an emerging infectious disease Hantavirus regulation of endothelial cell functions Hantavirus infection induces a typical myocarditis that may be responsible for myocardial depression and shock in hantavirus pulmonary syndrome Pulmonary involvement in nephropathia epidemica as demonstrated by computed tomography Impaired pulmonary function in patients with hemorrhagic fever with renal syndrome Pulmonary involvement in nephropathia epidemica: radiological findings and their clinical correlations Hantavirus pulmonary syndrome in New England and Europe Puumala virus pulmonary syndrome in a Romanian immigrant Puumala virus RNA in patient with multiorgan failure Corticosteroids combined with continuous veno-venous hemodiafiltration for treatment of hantavirus pulmonary syndrome caused by Puumala virus infection Outbreak of Puumala virus infection Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome Hantavirus pulmonary syndrome, 2010 case definition Hantavirus pulmonary syndrome: the new American hemorrhagic fever Outbreak of hantavirus pulmonary syndrome Electrocardiographic changes in patients with haemorrhagic fever with renal syndrome More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings Prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in Chile Acknowledgements Irene Eriksson and Ingrid Gustafsson are greatly acknowledged for their skilled technical assistance. keywords: hantavirus; infection; infiltrates; patients; pulmonary; puuv; rna; syndrome cache: cord-000364-ikq38rm1.txt plain text: cord-000364-ikq38rm1.txt item: #4 of 68 id: cord-002122-s2r0en6f author: Toom, Marjolein Lisette den title: Interstitial pneumonia and pulmonary hypertension associated with suspected ehrlichiosis in a dog date: 2016-07-07 words: 3483 flesch: 35 summary: Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe Ehrlichiosis and anaplasmosis in dogs and cats Epidemiologic, clinical, and laboratory findings of human ehrlichiosis in the United States Interstitial pneumonia in neonatal canine pups with evidence of canine distemper virus infection Chronic interstitial pneumonitis in dogs naturally infected with Leishmania (Leishmania) chagasi: a histopathological and morphometric study Radiographic aspects of Pneumocystis carinii pneumonia in the miniature Dachshund Molecular identification of Mycoplasma cynos from laboratory beagle dogs with respiratory disease Serial CT features of pulmonary leptospirosis in 10 dogs Cerebral babesiosis and acute respiratory distress syndrome in a dog Retrospective evaluation of moderate-to-severe pulmonary hypertension in dogs naturally infected with Angiostrongylus vasorum Bronchiolitis obliterans and pneumonia induced in young dogs by experimental adenovirus infection Pulmonary lesions in dogs with experimental and naturally occurring toxoplasmosis Pulmonary hypertension in dogs: diagnosis and therapy Reversible pulmonary hypertension presenting simultaneously with an atrial septal defect and angiostrongylosis in a dog Consensus statement on ehrlichial disease of small animals from the infectious disease study group of the ACVIM Animal model of fatal human monocytotropic ehrlichiosis A retrospective study of ehrlichiosis in 62 dogs from North Carolina and Virginia Atypical findings in 16 cases of canine ehrlichiosis Pulmonary hypertension associated with Ehrlichia canis infection in a dog Simultaneous detection of Anaplasma and Ehrlichia species in ruminants and detection of Ehrlichia ruminantium in Amblyomma variegatum ticks by reverse line blot hybridization Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview Comparison of nested PCR with immunofluorescent-antibody assay for detection of Ehrlichia canis infection in dogs treated with doxycycline Post-therapy antibody titers in dogs with ehrlichiosis: follow-up study on 68 patients treated primarily with tetracycline and/or doxycycline Significance of serological testing for ehrlichial diseases in dogs with special emphasis on the diagnosis of canine monocytic ehrlichiosis caused by Ehrlichia canis Reisolation of Ehrlichia canis from blood and tissues of dogs after doxycycline treatment Ehrlichiosis with severe pulmonary manifestations despite early treatment Near fatal acute respiratory distress syndrome in a patient with human ehrlichiosis Acute respiratory distress syndrome in human granulocytic ehrlichiosis Acute experimental canine ehrlichiosis. In dogs with canine monocytic ehrlichiosis (CME), respiratory signs are uncommon and clinical and radiographic signs of interstitial pneumonia are poorly described. keywords: canis; cme; dog; dogs; ehrlichiosis; hypertension; pulmonary; treatment cache: cord-002122-s2r0en6f.txt plain text: cord-002122-s2r0en6f.txt item: #5 of 68 id: cord-005646-xhx9pzhj author: None title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72090 flesch: 51 summary: Objective: To assess the normal ,gastric intramucosal pH ~Hi) by tonometry in healthy children Patients and methods: Twelve healthy children (6 males and 6 females) with age rmaged from 6 months to 12 years scheduled for minor plastic or urologic surgery. Pain relief was good (VRS less 2) in 53 children -94.6 % of study patients. keywords: acute; administration; admission; age; airway; analysis; ards; arterial; average; babies; blood; brain; cardiac; care; cases; changes; chest; children; complications; conclusion; cpb; criteria; data; days; death; diagnosis; difference; disease; dose; drug; duration; ecmo; effects; failure; flow; gas; group; heart; high; hospital; hours; hypertension; icu; ill; incidence; increase; infants; infusion; initial; injury; intensive; levels; life; lung; management; mean; measurements; mechanical; median; medical; methods; minutes; months; mortality; neonatal; neonates; newborns; nitric; non; nurses; outcome; oxide; oxygenation; parameters; patients; peak; pediatric; period; phi; picu; plasma; post; present; pressure; prism; pulmonary; range; rate; response; results; risk; score; sepsis; severe; severity; study; support; surgery; survivors; syndrome; system; test; therapy; time; total; treatment; unit; use; values; ventilation; volume; weeks; weight; years cache: cord-005646-xhx9pzhj.txt plain text: cord-005646-xhx9pzhj.txt item: #6 of 68 id: cord-005814-ak5pq312 author: None title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179325 flesch: 51 summary: Leukemia inhibitory factor (LIF), a growth factor recently recognised as a polyfunctional cytokine integrated in cytokine networks was measured in unconcentrated BALF of patients from different patient groups. It is difficult to generalize on intensive care units as different patient groups are in different ICUs aud there are great changes from one hospital to another and from one country to another. keywords: activity; acute; administration; admission; adult patients; age; aim; airway; analysis; apache; application; ards patients; arf; arterial; artery; assess; average; baseline; blood; blood flow; blood pressure; blood volume; breathing; cardiac; care patients; care unit; cases; catheter; cerebral; changes; chest; children; clinical; compliance; complications; concentration; conclusions; conditions; constant; control group; control patients; copd patients; correlation; course; cpb; criteria; critical; cvp; daily; damage; data; days; death; death patients; decrease; diagnosis; difference; disease; dose; drugs; duration; dysfunction; effect; emergency; end; evaluation; exchange; factors; failure; failure patients; findings; flow; fluid; following; frequency; function; gas; gastric; general; good; group; group b; group ii; group patients; h20; head; heart; hemodynamic; hepatic; hospital; hours; hypertension; icp; icu patients; iii; ill; illness; improvement; incidence; increase; index; infection; influence; infusion; injury; intensive; introduction; intubation; lactate; left; levels; life; liver; lung; male; management; map; mean; measurements; median; medical; methods; min; minutes; mmhg; model; monitoring; mortality; mortality rate; muscle; myocardial; need; negative; new; non; normal; number; objectives; onset; operation; order; organ; outcome; output; oxygen; oxygenation; p =; p<0.05; pao2; parameters; patients; patients methods; pattern; peep; perfusion; period; phase; phi; plasma; population; position; postoperative; presence; present; pressure; pressure support; procedure; protocol; pts; pulmonary; rain; range; rate; rats; reduction; renal; resistance; respiratory; response; results; right; risk; risk patients; samples; saps; score; sepsis; septic; serum; severe; severity; shock; shock patients; signs; specific; standard; status; stay; studies; study; study group; study period; subjects; support; surgery patients; surgical; survival; survivors; syndrome; system; systemic; technique; temperature; test; therapeutic; therapy; time; tissue; total; tracheal; transplantation; trauma patients; treatment; tube; type; unit; university; use; values; variables; vascular; vein; venous; ventilation; ventricular; volume; weaning; years cache: cord-005814-ak5pq312.txt plain text: cord-005814-ak5pq312.txt item: #7 of 68 id: cord-005941-e4fvj54l author: Hamm, H. title: The surfactant system of the adult lung: physiology and clinical perspectives date: 1992 words: 12905 flesch: 35 summary: Clq receptor binds other soluble proteins with collagen domains Specific interaction of lung surfactant protein A (SP-A) with rat alveolar macrophages Limitations of using urea to quantify epithelial lining fluid recovered by bronchalveolar lavage Surfactant in adult respiratory distress syndrome Surfactant apoprotein.-A concentration in sputum for diagnosis of pulmonary alveolar proteinosis Sublethal hyperoxic injury to the alveolar epithelium and the pulmonary surfactant system Characterization of antioxidant activities of pulmonary surfactant mixtures Idiopathic pulmonary fibrosis. The role of lung surfactant Role of pulmonary surfactant in the development and treatment of adult respiratory distress syndrome Effects of hemoglobin and cell membrane lipids on pulmonary surfactant activity Surface property changes from interactions of albumin with natural surfactant and extracted lung lipids Type II pneumocyte changes during hyperoxic lung injury and recovery Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages Changes in phospholipids in bronchoalveolar lavage fluid of patients with interstitial lung diseases Alterations of acidic phospholipids in bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis Dissolution and reassembly of tubular myelin-like multilamellated structures from the lungs of patients with pulmonary alveolar proteinosis A multicenter, randomized, placebo-controlled trial of surfactant therapy for respiratory distress syndrome Surface and tissue forces, surfactant protein A, and the phospholipid components of pulmonary surfactant in bleomycin-induced pulmonary fibrosis in the rat Changes in phosphatidylglycerol in bronchoalveolar lavage fluids from patients with cryptogenic fibrosing alveolitis Changes of alveolar stability and phospholipids in pulmonary surfactant in acute pancreatitis Surfactant for the treatment of respiratory distress syndrome Surfactant protein B : disulfide bridges, structural properties, and kringle similarities Human alveolar lining material and antibacterial defenses Types of interaction of amphiphilic drugs with phospholipid vesicles Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material Analysis of bronchoalveolar lavage and pulmonary alveolar surfactant for diagnosis of rejection and infection in heart-lung transplantation Alveolar type II cells, surfactant protein A (SP-A), and the phospholipid components of surfactant in acute silicosis in the rat Structure of alveolar epithelial cells in patients with fibrotic lung disorders Fluid dynamics during bronchoalveolar lavage Secretions from primary hamster tracheal surface epithelial cells in culture: mucin-like glycoproteins, proteoglycans, and lipids Isolation of apoproteins from canine surface active material -and pneumonia-induced lung injury. keywords: alveolar; alveolar type; bal; cells; changes; effects; lung; material; patients; phospholipids; protein; pulmonary; role; studies; surface; surfactant; synthesis; type; type ii cache: cord-005941-e4fvj54l.txt plain text: cord-005941-e4fvj54l.txt item: #8 of 68 id: cord-006428-l9akk8i6 author: Kuebler, W. M. title: Zelluläre Pathophysiologie der pulmonalen Hypertonie date: 2014-02-18 words: 3537 flesch: 19 summary: The role of the endothelium in pathophysiology and management Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32 New approaches to pulmonary hypertension: Will therapies in mice work in humans? Micropuncture measurement of lung microvascular profile during hypoxia in rats Role of pulmonary intravascular macrophages in anti-plateletinduced pulmonary hypertension in sheep Platelet aggregation in patients with primary pulmonary hypertension Proteins and phospholipids in BAL from patient with hydrostatic pulmonary edema Involvement of stretch-activated ion channels in Ca 2+ mobilization to mechanical stretch in endothelial cells Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32 Administration of chronic intravenous platelet-activating factor induces pulmonary arterial atrophy and hypertension in rabbits Different distribution of two types of angiotensin IIgenerating enzymes in the aortic wall Marked species-difference in the vascular angiotensin II-forming pathways: Humans versus rodents PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats Potential role for Kv3.1b channels as oxygen sensors Deleterious effects of hydralazine in patients with pulmonary hypertension Mitogenic effect of serotonin on vascular endothelial cells Effect of serotonin, thromboxane A 2 , and specific receptor antagonists on vascular smooth muscle cell proliferation Primary pulmonary hypertension Transpulmonary angiotensin II formation and pulmonary haemodynamics in stable hypoxic lung disease: The effect of captopril Pulmonary hypertension in healthy man born and living at high altitudes Histopathology of primary pulmonary hypertension. Da Thrombozytopenie die Entwicklung der Monocrotalin-induzierten PH und der konsekutiven Rechtsherzhypertrophie deutlich einschränkt bzw. sogar aufhebt (41, 62), kommt den Thrombozyten hinsichtlich der PH eine wichtige pathophysiologische Rolle zu. keywords: auch; auf; bei; calcium; cells; den; der; des; die; durch; eine; endothelial; hypertension; hypertonie; ist; lung; mit; oder; patienten; pph; pulmonalen; sich; und; vascular; von cache: cord-006428-l9akk8i6.txt plain text: cord-006428-l9akk8i6.txt item: #9 of 68 id: cord-006586-49btg9w7 author: Golfieri, R. title: Pulmonary complications of liver transplantation: radiological appearance and statistical evaluation of risk factors in 300 cases date: 2000 words: 7782 flesch: 34 summary: In addition, a highly significant correlation (p < 0.001) was observed between pneumonia-risk score and the expected survival, thus confirming pulmonary infections as a major cause of death in OLT recipients. The following clinical data were recorded and correlated to the onset of pulmonary infections and to the outcome: 1. keywords: cases; infections; liver; oedema; olt; onset; patients; pneumonia; pulmonary; risk; score; series cache: cord-006586-49btg9w7.txt plain text: cord-006586-49btg9w7.txt item: #10 of 68 id: cord-006608-mq4a4u40 author: Fabbri, Marilyn title: Hantavirus pulmonary syndrome in the United States date: 2001 words: 4578 flesch: 38 summary: key: cord-006608-mq4a4u40 authors: Fabbri, Marilyn; Maslow, Melanie J. title: Hantavirus pulmonary syndrome in the United States date: 2001 journal: Curr Infect Dis Rep DOI: 10.1007/s11908-001-0028-1 sha: doc_id: 6608 cord_uid: mq4a4u40 Since the first outbreak of hantavirus pulmonary syndrome (HPS) in 1993, understanding of the vast distribution and potential impact of hantaviruses has grown. RNA viruses with segmented genomes, such as influenza virus, Since the first outbreak of hantavirus pulmonary syndrome (HPS) in 1993, understanding of the vast distribution and potential impact of hantaviruses has grown. keywords: cases; hantavirus; hps; infection; outbreak; patients; person; rodent; snv; study; syndrome cache: cord-006608-mq4a4u40.txt plain text: cord-006608-mq4a4u40.txt item: #11 of 68 id: cord-007696-83v9yfa6 author: Zisman, David A. title: Pulmonary Fibrosis date: 2005 words: 14011 flesch: 32 summary: An analysis of multiple-cause mortality data Rising mortality from cryptogenic fibrosing alveolitis Cigarette smoking: a risk factor for idiopathic pulmonary fibrosis Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis Diabetes mellitus may increase risk for idiopathic pulmonary fibrosis Predicting survival in idiopathic pulmonary fibrosis: scoring system and survival model Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality Clinical significance of histological classification of idiopathic interstitial pneumonia Survival in patients with cryptogenic fibrosing alveolitis: a population-based cohort study The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis Determinants of survival in idiopathic pulmonary fibrosis Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis The role of gastroesophageal reflux in idiopathic pulmonary fibrosis Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis Exposure to commonly prescribed drugs and the etiology of cryptogenic fibrosing alveolitis: a case-control study Occupational and environmental risk factors for idiopathic pulmonary fibrosis: a multicenter casecontrol study. Collaborating Centers Cryptogenic fibrosing alveolitis and Epstein-Barr virus: an association? Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis The detection of Epstein-Barr virus DNA in lung tissue from patients with idiopathic pulmonary fibrosis A rearranged form of Epstein-Barr virus DNA is associated with idiopathic pulmonary fibrosis Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis Idiopathic pulmonary fibrosis and hepatitis C virus infection Incidence of hepatitis C virus infection in Italian patients with idiopathic pulmonary fibrosis Idiopathic pulmonary fibrosis and high prevalence of serum antibodies to hepatitis C virus Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction Usual interstitial pneumonia following Texas A2 influenza infection Clinical course, management, and long-term sequelae of respiratory failure due to influenza viral pneumonia Studies on influenza in the pandemic of 1957-1958. keywords: alveolitis; diagnosis; disease; effects; expression; factor; fibrosing; fibrosis; function; ifn; ipf; lung; nsip; patients; pneumonia; pulmonary; studies; study; survival; therapy; treatment; uip cache: cord-007696-83v9yfa6.txt plain text: cord-007696-83v9yfa6.txt item: #12 of 68 id: cord-007797-toam6r5y author: Franquet, Tomás title: Imaging of Pulmonary Infection date: 2019-02-20 words: 4853 flesch: 26 summary: In 90% of patients with Pneumocystis jiroveci, pneumonia chest radiographs show diffuse bilateral infiltrates in a perihilar distribution ( Fig. 7.5) . Pulmonary infection is characterized pathologically by bronchopneumonia with focal or multifocal abscess formation. keywords: chest; consolidation; disease; findings; ground; infection; nodules; opacities; patients; pneumonia; pulmonary cache: cord-007797-toam6r5y.txt plain text: cord-007797-toam6r5y.txt item: #13 of 68 id: cord-008510-mnpu27kl author: Lipscomb, Mary F. title: The Regulation of Pulmonary Immunity date: 2008-04-10 words: 30224 flesch: 29 summary: Demonstration that lung cells regulate both nonspecific inflammation and immunity through the expression of adhesion molecules and the secretion of cytokines offers hope for ways to design more effective vaccines, enhance microbial clearance in immune-suppressed hosts, and to suppress manifestations of immunologically mediated lung disease. Lung macrophages are the most difficult cells to separate from DCs in single cell suspensions of lung cells. keywords: acute; airway; allograft; alveolar; animals; antibody; antigen; b cells; cd4; cells; clearance; dcs; dendritic; development; disease; et al; expression; function; host; human; hypersensitivity; ifny; immune; immunity; immunization; infection; inflammation; lung; lung cells; lung dcs; lymphocytes; macrophages; mechanisms; mice; model; mtb; murine; production; pulmonary; rat; rejection; response; role; specific; studies; t cells; tract cache: cord-008510-mnpu27kl.txt plain text: cord-008510-mnpu27kl.txt item: #14 of 68 id: cord-010078-8lkkez3n author: None title: Invited Speakers date: 2010-11-24 words: 21364 flesch: 41 summary: The SIRT1 is decreased in alveolar macrophages of smokers and COPD patients, and associated with pro-infl ammatory response through the activation of NF-κB. Understanding the complexity of infl ammatory and epigenetic regulations in chronic lung diseases may potentiate the development of novel therapies. In China, non-smokers accounted for 38.6% of COPD patients compared with 24.9% in USA and 22.9% in the UK. keywords: acute; airway; asthma; bronchitis; cancer; care; cells; chronic; copd; copd patients; cough; countries; data; diagnosis; disease; factors; function; group; health; infl; lung; new; non; patients; pleural; prevalence; pulmonary; risk; signifi; smoking; stage; studies; study; symptoms; therapy; treatment; trials; use cache: cord-010078-8lkkez3n.txt plain text: cord-010078-8lkkez3n.txt item: #15 of 68 id: cord-010697-0eutz8xy author: Roumy, Aurélien title: Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review date: 2020-05-11 words: 5398 flesch: 26 summary: In case of chronic decrease of pulmonary blood flow (e.g., in chronic thromboembolic disease or pulmonary stenosis), the bronchial flow may increase from 1 to 30% of the cardiac output, permitting to compensate this decrease and participate to gas exchange, providing a kind of rescue flow to the ischemic areas [55, 56] . Ventilation with high positive end-expiratory pressure (PEEP) might also impede pulmonary blood flow by compression of alveolar vessels [58] . keywords: alveolar; blood; ecmo; extracorporeal; flow; lung; membrane; oxygenation; patients; pulmonary; support cache: cord-010697-0eutz8xy.txt plain text: cord-010697-0eutz8xy.txt item: #16 of 68 id: cord-015836-ojx04jsh author: Lynch, Joseph P. title: Idiopathic Pulmonary Fibrosis date: 2011-07-12 words: 11335 flesch: 45 summary: Surveys of IPF patients in the UK and USA noted that progression of lung disease accounted for 72% [ 32 ] and 60% [ 33 ] of deaths, respectively. In one study of IPF patients awaiting LT, survival time was shorter among patients with 6MWD < 350 m keywords: brosis; disease; fi brosis; interstitial; ipf; lung; months; mortality; patients; pulmonary; studies; study; survival; uip; years cache: cord-015836-ojx04jsh.txt plain text: cord-015836-ojx04jsh.txt item: #17 of 68 id: cord-016009-qa7bcsbu author: Starkel, Julie L. title: Respiratory date: 2019-10-07 words: 22281 flesch: 42 summary: In Europe, lung disease represents 15% of all deaths -the fourth leading cause. Added together, lung disease rivals the position for the top cause of death. keywords: acid; antioxidant; asthma; body; cancer; cells; children; chronic; copd; deficiency; diet; disease; exposure; fibrosis; function; glutathione; health; immune; inflammation; intake; iron; levels; liver; low; lung; lung cancer; lung disease; patients; pulmonary; research; risk; role; status; stress; study; symptoms; tissue; treatment; vitamin cache: cord-016009-qa7bcsbu.txt plain text: cord-016009-qa7bcsbu.txt item: #18 of 68 id: cord-016690-3gsq724l author: Li, Hongjun title: HIV/AIDS Related Respiratory Diseases date: 2013-09-30 words: 26773 flesch: 44 summary: Pathogens of HIV related pulmonary infections include parasites, fungi, mycobacteria, viruses, bacteria and toxoplasma gondii. In this section, the clinical manifestations and imaging findings of HIV related pulmonary infections are analyzed and discussed, which provide effective diagnosis basis, so as to reduce the incidence of HIV-related pulmonary infections. keywords: aids; aids patients; bronchial; cancer; cases; cd4; cell; changes; chest; cough; count; diagnosis; fever; hiv; imaging; infection; infi; lesions; lung; manifestations; nodules; parenchymal; patients; pneumonia; pulmonary; ray; shadows; symptoms; tuberculosis; type cache: cord-016690-3gsq724l.txt plain text: cord-016690-3gsq724l.txt item: #19 of 68 id: cord-016973-s32jp0ej author: Menon, Nithya title: Respiratory Diseases of Pregnancy date: 2016-07-21 words: 2464 flesch: 38 summary: Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study Epidemiology of pregnancy-associated venous thromboembolism: a population-based study in Canada Pregnancy and the lungs Successful use of noninvasive ventilation in pregnancy Implications for the pregnant patient Mechanical ventilation during pregnancy: sedation, analgesia, and paralysis Systemic inflammatory response syndrome, organ failure, and outcome in critically ill obstetric patients treated in an icu Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic Modern use of extracorporeal life support in pregnancy and postpartum Prone positioning for ARDS following blunt chest trauma in late pregnancy How safe is the prone position in acute respiratory distress syndrome at late pregnancy Does delivery improve maternal condition in the respiratory-compromised gravida? key: cord-016973-s32jp0ej authors: Menon, Nithya; Reed, Mary Jane title: Respiratory Diseases of Pregnancy date: 2016-07-21 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-319-43341-7_89 sha: doc_id: 16973 cord_uid: s32jp0ej Respiratory complaints in the gravid patient are often difficult to identify as a disease state, expected physiologic changes of pregnancy or both. keywords: edema; patients; pregnancy; pressure; risk; use; ventilation cache: cord-016973-s32jp0ej.txt plain text: cord-016973-s32jp0ej.txt item: #20 of 68 id: cord-017016-twwa9djm author: Tomashefski, Joseph F. title: Aspiration, Bronchial Obstruction, Bronchiectasis, and Related Disorders date: 2008 words: 20063 flesch: 32 summary: A study of 36 cases with special reference to the pulmonary lesions The bronchial mucous glands-their hypertrophy and change in intracellular mucus Similarity of the tracheobronchial mucous glands and epithelium in infants with and without cystic fibrosis The innate immune system in cystic fibrosis lung disease The genesis of cystic fibrosis lung disease Pathogenesis of bacterial bronchitis in cystic fibrosis Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology How mutant CFTR may contribute to Pseudomonas aeruginosa infection in cystic fibrosis Lung infections associated with cystic fibrosis Bacterial infections and inflammation in the lungs of cystic fibrosis patients Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation Cystic fibrosis lung inflammation: early, sustained and severe Inflammatory cytokines in cystic fibrosis lungs Normal bronchial epithelial cells constitutively produce the antiinflammatory cytokine interleukin-lO, which is downregulated in cystic fibrosis Early pulmonary inflammation in infants with cystic fibrosis Cytokine secretion by cystic fibrosis airway epithelial cells Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. 279,28o It has long been recognized that patients with CF are predisposed to lung infection. keywords: abscess; acid; airway; aspiration; associated; bronchial; bronchiectasis; cases; cause; cells; chapter; children; chronic; ciliary; cystic; disease; fibrosis; fig; foreign; infection; inflammation; lipid; lobe; lung; lung abscess; lung disease; obstruction; patients; pneumonia; primary; pulmonary; study; syndrome; tissue; young cache: cord-017016-twwa9djm.txt plain text: cord-017016-twwa9djm.txt item: #21 of 68 id: cord-017105-mljywm9p author: Jain, Amisha title: Pulmonary Complications of Obstetric and Gynecologic Conditions date: 2017-10-24 words: 7734 flesch: 37 summary: There is a bidirectional interaction of asthma and pregnancy where asthma influences pregnancy outcomes and pregnancy affects asthma severity. However, the reproductive system can exert significant effects on the respiratory system as a result of the various hormonal changes that occur during a woman’s menstrual cycle and especially during pregnancy. keywords: asthma; changes; chest; diagnosis; disease; lam; lung; osa; patients; pneumothorax; pregnancy; pulmonary; respiratory; risk; treatment; women cache: cord-017105-mljywm9p.txt plain text: cord-017105-mljywm9p.txt item: #22 of 68 id: cord-017248-a37t31u1 author: None title: Alphabetic Listing of Diseases and Conditions date: 2010-05-17 words: 48773 flesch: 37 summary: Peptic ulcers may be associated with emphysema,* tuberculosis,* and other chronic pulmonary diseases. Procedures See under Alcoholism and alcohol intoxication. keywords: abnormalities; acute; air; alcohol; analysis; aorta; aortic; arteries; artery; atresia; autopsy; blood; body; bone; brain; cases; cause; cell; cerebral; changes; chapter; chronic; column; concentrations; conditions; congenital; coronary; death; defect; deficiency; diagnosis; disease; dissection; embolism; evidence; examination; findings; formalin; gas; hand; heart; histologic; histologic study; infection; lesions; liver; lung; manifestations; material; neck; note; organs; patients; photograph; pneumonia; poisoning; preparation; prepare; present; procedures; pulmonary; record; removal; renal; report; request; right; roentgenograms; samples; sections; skin; specimen; spinal; stain; study; syndrome; synonyms; terms; time; tissue; toxicologic; tumor; type; valve; ventricular; vessels; victim; water; weight cache: cord-017248-a37t31u1.txt plain text: cord-017248-a37t31u1.txt item: #23 of 68 id: cord-017581-6lubp7io author: Glass, Daniel M. title: Respiratory Diseases of Pregnancy date: 2019-07-24 words: 2516 flesch: 38 summary: Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study Epidemiology of pregnancyassociated venous thromboembolism: a population-based study in Canada Pregnancy and the lungs Successful use of noninvasive ventilation in pregnancy Implications for the pregnant patient Mechanical ventilation during pregnancy: sedation, analgesia, and paralysis Systemic inflammatory response syndrome, organ failure, and outcome in critically ill obstetric patients treated in an icu Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic Modern use of extracorporeal life support in pregnancy and postpartum Prone positioning for ARDS following blunt chest trauma in late pregnancy How safe is the prone position in acute respiratory distress syndrome at late pregnancy Does delivery improve maternal condition in the respiratory-compromised gravida? key: cord-017581-6lubp7io authors: Glass, Daniel M.; Zehrer, Tara; Al-Khafaji, Ali title: Respiratory Diseases of Pregnancy date: 2019-07-24 journal: Evidence-Based Critical Care DOI: 10.1007/978-3-030-26710-0_99 sha: doc_id: 17581 cord_uid: 6lubp7io Pregnant patients can suffer from the same respiratory diseases as the general population in addition to unique syndromes of pregnancy (such as pre-eclampsia and tocolytic induced pulmonary edema, and pregnancy induced cardiomyopathy). keywords: edema; patients; pregnancy; pressure; risk; use; ventilation cache: cord-017581-6lubp7io.txt plain text: cord-017581-6lubp7io.txt item: #24 of 68 id: cord-017771-g72qaoub author: Lohan, Rahul title: Imaging of ICU Patients date: 2019-01-15 words: 3759 flesch: 37 summary: The diagnosis of pneumonia in ICU patients is often challenging as the airspace opacities seen on chest radiographs in these patients can be caused by atelectasis, aspiration, pulmonary hemorrhage, noninfectious lung inflammation (e.g., drug reaction), pulmonary edema, or ARDS The common pulmonary parenchymal disease processes in ICU patients include hydrostatic pulmonary edema, acute respiratory distress syndrome (ARDS), atelectasis, pneumonia, aspiration, and pulmonary hemorrhage. keywords: chest; edema; fig; icu; imaging; patients; pulmonary; tube cache: cord-017771-g72qaoub.txt plain text: cord-017771-g72qaoub.txt item: #25 of 68 id: cord-017983-ehxpdavo author: Lee, Joyce S. title: Acute Exacerbation of Idiopathic Pulmonary Fibrosis date: 2013-09-13 words: 4066 flesch: 33 summary: An autopsy study Acute exacerbation (acute lung injury of unknown cause) in UIP and other forms of fi brotic interstitial pneumonias CT fi ndings during phase of accelerated deterioration in patients with idiopathic pulmonary fi brosis Pirfenidone in patients with idiopathic pulmonary fi brosis (CAPACITY): two randomised trials BUILD-3: a randomized, controlled trial of bosentan in idiopathic pulmonary fi brosis Incidence, prevalence, and clinical course of idiopathic pulmonary fi brosis: a populationbased study Anticoagulant therapy for idiopathic pulmonary fi brosis Double-blind, placebocontrolled trial of pirfenidone in patients with idiopathic pulmonary fi brosis Effi cacy of a tyrosine kinase inhibitor in idiopathic pulmonary fi brosis A Placebocontrolled randomized trial of warfarin in idiopathic pulmonary fi brosis An Offi cial ATS/ERS/ JRS/ALAT statement: idiopathic pulmonary fi brosis: evidence-based guidelines for diagnosis and management The acute respiratory distress syndrome Snyder 3rd WH. Previous or concurrent diagnosis of idiopathic pulmonary fi brosis Unexplained development or worsening of dyspnea within 30 days High-resolution computed tomography with new bilateral ground-glass abnormality and/or consolidation superimposed on a background reticular or honeycomb pattern consistent with usual interstitial pneumonia keywords: acute; aex; brosis; exacerbation; fi brosis; ipf; patients; pulmonary cache: cord-017983-ehxpdavo.txt plain text: cord-017983-ehxpdavo.txt item: #26 of 68 id: cord-017998-tcf2mr1h author: Sayer, Gabriel title: Acute and Chronic Right Ventricular Failure date: 2017-02-22 words: 6334 flesch: 41 summary: Changes in the pulmonary vascular resistance, either acutely or over time, provoke a series of adaptations that are designed to maintain a normal cardiac output, but ultimately lead to decompensation and RV failure. Through ventricular interdependence, RV failure may impair left ventricular diastolic and systolic function, further reducing cardiac performance. keywords: cardiac; disease; dysfunction; failure; heart; patients; pressure; right; ventricular cache: cord-017998-tcf2mr1h.txt plain text: cord-017998-tcf2mr1h.txt item: #27 of 68 id: cord-018168-j85m7wno author: d’Ortho, Marie-Pia title: MMPs, inflammation and pulmonary arterial hypertension date: 2008 words: 5468 flesch: 23 summary: [27] showed that a serine elastase was produced by aortic smooth muscle cells and associated with atherosclerosis, which was further characterised by Zhu et al. in pulmonary artery smooth muscle cells as the Endogenous Vascular Elastase (EVE) The development of intimal hyperplasia after vascular injury is diminished in plasminogen-deficient mice, supporting the concept that plasmin associated with vascular smooth muscle cells enhances cell migration by fostering extracellular matrix degradation, either directly or indirectly by activating matrix metalloproteinases [36] . keywords: arteries; cell; gene; hypertension; matrix; muscle; pah; plasminogen; pulmonary; receptor; smooth; vascular cache: cord-018168-j85m7wno.txt plain text: cord-018168-j85m7wno.txt item: #28 of 68 id: cord-018209-v2crgj5w author: Pastores, Stephen M. title: What Has Been Learned from Postmortem Studies? date: 2010-08-19 words: 5277 flesch: 24 summary: DAD has been reported at autopsy in 63.5% of patients with treated leukemia and lymphoma and close to 50% among HSCT patients [7, 8] . Infections as the cause of DAD are identified on autopsy in only a third of HSCT patients, while approximately 20% have DAH. keywords: alveolar; autopsy; diagnosis; discrepancies; hemorrhage; hsct; infections; malignancies; patients; pulmonary; recipients; transplantation cache: cord-018209-v2crgj5w.txt plain text: cord-018209-v2crgj5w.txt item: #29 of 68 id: cord-018243-hyvu9nuq author: Salman, Huda title: Fibrosing Alveolitis in Hematologic Malignancy Patients Undergoing Hematopoietic Cell Transplantation date: 2010-08-19 words: 6992 flesch: 27 summary: Hence, while opportunistic infections still contribute to chronic lung disease, late sequelae resulting from antineoplastic therapy have been identified and reported. Chronic pulmonary disease following allogeneic HSCT likely involves an initial insult to lung parenchyma followed by an ongoing inflammatory process involving the interplay between recruited donor-derived immune cells and the resident cells of the pulmonary vascular endothelium and interstitium. keywords: acute; chronic; disease; drug; fibrosis; gvhd; hsct; injury; lung; patients; pulmonary; radiation; therapy; toxicity; transplantation cache: cord-018243-hyvu9nuq.txt plain text: cord-018243-hyvu9nuq.txt item: #30 of 68 id: cord-018339-tyrlpl94 author: Dsouza, Kevin title: Late Noninfectious Pulmonary Complications in Hematopoietic Stem Cell Transplantation date: 2019-07-09 words: 5741 flesch: 28 summary: Management of Epstein-Barr Virus infections and post-transplant lymphoproliferative disorders in patients after allogeneic hematopoietic stem cell transplantation Bronchiolitis obliterans organizing pneumonia as a complication of allogeneic bone marrow transplantation Etanercept and corticosteroid therapy for the treatment of late-onset idiopathic pneumonia syndrome High-dose corticosteroids with or without etanercept for the treatment of idiopathic pneumonia syndrome after allo-SCT Outcome and treatment of late-onset noninfectious pulmonary complications after allogeneic haematopoietic SCT Bronchiolitis obliterans after allo-SCT: clinical criteria and treatment options Early onset noninfectious pulmonary syndromes after hematopoietic cell transplantation The association between red blood cell and platelet transfusion and subsequently developing idiopathic pneumonia syndrome after hematopoietic stem cell transplantation The association between platelet transfusion and idiopathic pneumonia syndrome is unaffected by platelet product type Lung transplantation for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation: a singlecenter experience Pleuroparenchymal fibroelastosis in patients with pulmonary disease secondary to bone marrow transplantation A randomised controlled trial of azithromycin to prevent chronic rejection after lung transplantation Pleuroparenchymal fibroelastosis: its clinical characteristics Interstitial pneumonitis after bone marrow transplantation. Radiographics Organizing pneumonia in recipients of hematopoietic stem cell transplantation: CT features in 16 patients The diagnostic value of bronchoalveolar lavage and transbronchial lung biopsy in cryptogenic organizing pneumonia High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children Air-leak syndrome following allo-SCT in adult patients: report from the Kanto Study Group for Cell Therapy in Japan Dose response and factors related to interstitial pneumonitis after bone marrow transplant Risk factors for bronchiolitis obliterans in allogeneic hematopoietic stem-cell transplantation for leukemia Post-transplantation lymphoproliferative disorder: the spectrum of imaging appearances Human biomarker discovery and predictive models for disease progression for idiopathic pneumonia syndrome following allogeneic stem cell transplantation Idiopathic pneumonia syndrome after hematopoietic cell transplantation: evidence of occult infectious etiologies Idiopathic pneumonia syndrome after allogeneic bone marrow transplantation in mice. keywords: allogeneic; bronchiolitis; cell; complications; hsct; obliterans; onset; pneumonia; post; pulmonary; stem; syndrome; transplantation cache: cord-018339-tyrlpl94.txt plain text: cord-018339-tyrlpl94.txt item: #31 of 68 id: cord-018414-6ffhm895 author: Kang, Yoogoo title: Anesthesia Management of Liver Transplantation date: 2016-07-22 words: 21167 flesch: 28 summary: Liver transplantation requires a true multidisciplinary approach, and anesthesiologists and intensivists have played a major role in the successful outcome of liver transplantation. Right ventricular function during orthotopic liver transplantation Adult respiratory distress syndrome secondary to endstage liver disease-successful outcome following liver transplantation Use of intraoperative blood salvage during orthotopic liver transplantation Compression of the brachial plexus injury during right lobe liver donation as a cause of brachial plexus injury: a case report Rapid infusion devices for hemorrhagic cardiothoracic trauma Liver transplantation: effect of washing bank blood on intraoperative control of hyperkalemia Right heart dysfunction, pulmonary embolism, and paradoxical embolization during liver transplantation. keywords: administration; anesthesia; arterial; artery; blood; bypass; cardiac; coagulation; disease; dysfunction; et al; factors; failure; flow; function; hepatic; hypertension; ivc; level; liver; liver disease; liver transplantation; loss; output; patients; portal; pressure; reperfusion; right; serum; stage; syndrome; transplantation; vascular; vein; venous cache: cord-018414-6ffhm895.txt plain text: cord-018414-6ffhm895.txt item: #32 of 68 id: cord-018601-mk66097y author: Michelakis, Evangelos D. title: Pulmonary Arterial Hypertension date: 2007 words: 26309 flesch: 39 summary: Studying PAH pulmonary arteries with either a plexiform lesion or intimal or medial hypertrophy, one is impressed by the increased cellularity in the vascular wall. Pulmonary hypertensive patients may be intolerant to vasovagal reactions that may occur during attempted vascular access. keywords: arterial; arteries; artery; cells; channels; chronic; circulation; class; disease; effects; endothelial; fig; group; heart; hypertension; hypoxia; ipah; levels; lung; pah; pah patients; patients; pht; pressure; primary; pulmonary; right; sildenafil; study; survival; systemic; therapy; vascular; ventricular cache: cord-018601-mk66097y.txt plain text: cord-018601-mk66097y.txt item: #33 of 68 id: cord-019001-ralxw4ad author: Oishi, Peter title: Diseases of the Pulmonary Vascular System date: 2008-11-15 words: 12802 flesch: 23 summary: Other, less common causes of pediatric pulmonary vascular disease include primary (idiopathic) pulmonary hypertension, hypoxiainduced pulmonary vascular disease, rheumatologic disorders, sickle cell disease, portal hypertension, chronic thromboembolic disease, human immunodefi ciency virus disease, and drug-toxin induced disease. Finally, a genetic disposition appears to be important in some subtypes of pulmonary vascular disease and remains an area of active research. keywords: acute; arterial; blood; disease; effects; endothelial; heart; hypertension; lung; nitric; oxide; patients; pressure; prostacyclin; pulmonary; resistance; therapy; vascular cache: cord-019001-ralxw4ad.txt plain text: cord-019001-ralxw4ad.txt item: #34 of 68 id: cord-019063-mcxbl8mv author: Vijayan, Vannan K. title: Diagnosis of Pulmonary Parasitic Diseases date: 2013-06-05 words: 6672 flesch: 35 summary: World Health Organization Laboratory diagnosis of malaria infection-a short review of methods Malaria diagnosis: a brief review Rapid diagnostic tests for malaria parasites Rapid diagnostic testing for malaria A review of malaria diagnostic tools: microscopy and rapid diagnostic test (RDT) Co-infections acquired from Ixode ticks Acute respiratory failure in patients treated for babesiosis Diagnosis of pulmonary infection with Toxoplasma gondii in immunocompromised HIV-positive patients by real time PCR Clinical and diagnostic management of toxoplasmosis in the immunocompromised patient Eosinophilic lung disease in the tropics Parasitic diseases of the respiratory tract Spontaneous rupture of lung echinococcal cyst causing anaphylactic shock and respiratory distress syndrome Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD Pulmonary cystic echinococcosis Echinococcus multilocularis Disseminated alveolar echinococcosis mimicking a metastatic malignancy The immunodiagnosis of Echinococcus multilocularis infection Pulmonary schistosomiasis Pulmonary manifestations of early Schistosoma infection in nonimmune travelers Katayama fever; an acute manifestation of schistosomiasis Schistosomiasis associated pulmonary hypertension A diagnostic dilemma of right lower lobe collapse caused by pulmonary bilharsiasis Acute schistosomiasis in nonimmune travelers: chest CT fi ndings in 10 patients Pathophysiology, diagnosis, and treatment Detection of circulating antigens in patients with active Schistosoma haematobium infection Studies on clinical manifestations, diagnosis and control of paragonimiasis in China Pulmonary paragonimiasis: an evaluation of roentgen fi ndings in 38 positive sputum patients in an endemic area in Thailand Clinicoradiologic features of pleuropulmonary Paragonimus westermani on Kyushu Island Evaluation of human IgG subclass antibodies in the serodiagnosis of Paragonimus heterotremus Tropical parasitic lung diseases Strongyloidiasis and other intestinal nematode infections Eosinophilic lung disease (or how to slice PIE) Ascariasis and hookworm Possible approach for serodiagnosis of ascariasis by evaluation of immunoglobulin G4 response using Ascaris lumbricoides somatic antigen Nature and causes of hookworm anemia Differentiation between the human hookworm Ancylostoma duodenale and Necator americanus using PCR-RFLP Biology and immunology of human strongyloidiasis Disseminated Strongyloides stercoralis in human immunodefi ciency virus-infected patients: treatment failure and review of literature Pulmonary manifestations of strongyloidiasis Strongyloides stercoralis infestation associated with septicemia due to intestinal transmural migration of bacteria Corticosteroidinduced asthma: a manifestation of limited hyperinfection syndrome due to Strongyloides stercoralis Diagnosis of Strongyloides stercoralis infection A simple modification of the Baermann method for diagnosis of strongyloidiasis Evaluation of three methods for laboratory diagnosis of Strongyloides stercoralis infection Diagnosis of pulmonary strongyloidiasis by bronchoalveolar lavage Serology and eosinophil count in the diagnosis and management of strongyloidiasis in a non-endemic area Tropical pulmonary eosinophilia Acute tropical pulmonary eosinophilia: characterization of the lower respiratory tract infl ammation and its response to therapy Tropical pulmonary eosinophilia: analysis of antifi larial antibody localized to the lung Pulmonary eosinophilia: progress in respiration research Tropical pulmonary eosinophilia Re-examination of the diagnostic criteria of tropical pulmonary eosinophilia In certain situations, invasive investigations such as fiberoptic bronchoscopic evaluation (transbronchial lung biopsies and bronchoalveolar lavage studies) and thoracic surgical procedures (thoracoscopy and open lung biopsy) may be required for a diagnosis and also to exclude other lung diseases. keywords: acute; blood; chest; detection; diagnosis; diseases; eosinophilia; histolytica; infection; lung; malaria; parasites; parasitic; patients; pulmonary; symptoms cache: cord-019063-mcxbl8mv.txt plain text: cord-019063-mcxbl8mv.txt item: #35 of 68 id: cord-021742-sdz6d1r5 author: Karnik, Ankur A. title: Pneumothorax and Barotrauma date: 2009-05-15 words: 13485 flesch: 36 summary: A multicenter, prospective, randomized pilot study Simple aspiration versus chest-tube insertion in the management of primary spontaneous pneumothorax: A systematic review Chest tubes: indications, techniques, management and complications Recurrent re-expansion pulmonary edema Chest tube removal: End-inspiration or end-expiration? Delayed pulmonary perforation: A rare complication of the tube thoracostomy Complications of percutaneous dart therapy in management of pneumothorax Treatment of pneumothoraces utilizing small caliber chest tubes Role of small caliber chest tube drainage for iatrogenic pneumothorax Pigtail tube drainage in the treatment of spontaneous pneumothorax The thoracic vent: Clinical experience with a new device for treating simple pneumothorax Use of a pleural catheter for the management of simple pneumothorax Spontaneous pneumothorax Spontaneous pneumothorax in Norfolk Management of secondary spontaneous pneumothorax. Effects on recurrence and lung transplantation complications Persistent air leak in spontaneous pneumothorax-clinical course and outcome A prospective algorithm for the management of air leaks after pulmonary resection Autologous blood patch pleurodesis for persistent pulmonary air leak Autologous blood patch pleurodesis for secondary spontaneous pneumothorax with persistent air leak Intrapleural administration of a large amount of diluted fi brin glue for intractable pneumothorax Medical management and therapy of bronchopleural fi stulas in the mechanically ventilated patient Pectoral myoplasty for recurrent pneumothorax: An extrathoracic solution to an intrathoracic problem The treatment of refractory pneumothorax in diffuse panbronchiolitis by intravenous administration of coagulation factor XIII concentrate Closure of a bronchopleural fi stula using bronchoscopic placement of an endobronchial valve designed for the treatment of emphysema Acute pulmonary edema following treatment of spontaneous pneumothorax with excessive negative intrapleural pressure Clinical analysis of reexpansion pulmonary edema Unilateral pulmonary edema resulting from treatment of spontaneous pneumothorax Experimental pulmonary edema following re-expansion of pneumothorax Evidence for increased permeability in reexpansion pulmonary edema Changes in pulmonary microvascular permeability accompanying re-expansion oedema: keywords: air; aspiration; barotrauma; bilateral; cases; chest; colleagues; complication; disease; lung; management; needle; patients; pleural; pleurodesis; pneumothoraces; pneumothorax; pressure; recurrence; risk; syndrome; thoracentesis; treatment; tube cache: cord-021742-sdz6d1r5.txt plain text: cord-021742-sdz6d1r5.txt item: #36 of 68 id: cord-022082-1dq623oe author: Greaves, Peter title: Respiratory Tract date: 2007-09-28 words: 19712 flesch: 22 summary: ^^^ Plasticembedded sections also show the inclusions in other pulmonary cells including pneumocytes attached to the alveolar walls, from which they can be seen discharging into the alveolar spaces. In contrast to findings in people, squamous cell lung tumours are only occasionally seen arising spontaneously in laboratory animals. keywords: administration; agents; airways; alveolar; animals; bronchial; cells; changes; drug; effects; epithelium; fibrosis; humans; hyperplasia; inhalation; laboratory; laboratory animals; lesions; lung; macrophages; mice; mucosa; nasal; olfactory; pulmonary; rats; respiratory; species; studies; study; tissue; toxicity; tract; type cache: cord-022082-1dq623oe.txt plain text: cord-022082-1dq623oe.txt item: #37 of 68 id: cord-022173-kb6mez61 author: Calvillo Batllés, P. title: Hematologic neoplasms: Interpreting lung findings in chest computed tomography() date: 2015-11-06 words: 5376 flesch: 29 summary: 18-FDG PET-CT is not only useful for the staging and follow up of metabolically-active lymphomas 69 but also a pathological uptake in the absence of pulmonary findings in the HRCT can raise early suspicion of drug toxicity 70, 71 or leukemic infiltration and it can be useful to differentiate active lesion scarring (whether toxic, infectious or tumoral). Expiration Before-HPT Rituximab is an anti-CD20 monoclonal antibody used in the treatment of lymphoproliferative B syndromes that have been associated to pulmonary disease due to a mechanism that has not been clarified yet after a median of four cycles and with a median time of appearance of 4 weeks after the last infusion. keywords: diagnosis; disease; findings; hpt; nodes; patients; pneumonia; pulmonary; tomography; treatment cache: cord-022173-kb6mez61.txt plain text: cord-022173-kb6mez61.txt item: #38 of 68 id: cord-023311-7wqdlha4 author: None title: Oral Session date: 2010-11-24 words: 17283 flesch: 47 summary: Conclusion Depression and anxiety were also found in lung cancer patients and need further evaluation and attention from clinician. Methods Patients with medically inoperable or unresectable single nodule NSCLC underwent treatments, in 3 different centers of Bangladesh. keywords: age; airway; asthma; children; conclusion; copd; data; day; diagnosis; disease; group; hospital; infl; introduction; lung; mean; methods; months; mortality; patients; pneumonia; pulmonary; respiratory; results; signifi; sputum; study; total; treatment; tuberculosis; years cache: cord-023311-7wqdlha4.txt plain text: cord-023311-7wqdlha4.txt item: #39 of 68 id: cord-023509-tvqpv6fp author: Corrin, Bryan title: Occupational, environmental and iatrogenic lung disease date: 2011-03-02 words: 42595 flesch: 39 summary: Aluminium powder holds a paradoxical position in regard to lung disease. 366 More directly, welders may be exposed to asbestos insulation that they themselves use, while welders of special steel alloys run the risk of metal-induced asthma, metal fume fever, polymer fume fever and the consequences of toxic metal fume inhalation, 367 all of which are described separately in this chapter, as is lung disease in aluminium welders. keywords: acute; air; aluminium; alveolar; analysis; asbestos; asbestos exposure; asbestos fibres; asthma; beryllium; blood; bodies; bronchiolitis; cases; cause; cells; changes; chronic; coal; damage; diffuse; drug; dust; dust exposure; dust pneumoconiosis; effects; electron; emphysema; evidence; exposure; factor; fibres; fibrosis; fig; gas; interstitial; lesions; lung; lung cancer; lung disease; lung injury; lung tissue; macrophages; mineral; non; occupational; oedema; oxygen; particles; patients; pneumoconiosis; pneumonia; pulmonary; risk; silica; silicosis; smoking; study; syndrome; tissue; toxicity; type; water; workers cache: cord-023509-tvqpv6fp.txt plain text: cord-023509-tvqpv6fp.txt item: #40 of 68 id: cord-024183-1mrdjc39 author: Hutchison, Alastair A. title: The Respiratory System date: 2013-10-08 words: 28100 flesch: 39 summary: and Flow/Volume Control In adult humans the glottis opens maximally during inspiration, closes gradually to a minimum about three quarters through expiration, and then opens again in late expiration (England et al. 1982a ). (From O'Connor, D. Reproduced with permission from Myer et al. keywords: adults; age; airway; asthma; bpd; breathing; changes; chest; children; closure; compliance; disease; et al; expiratory; fev; flow; frc; function; growth; increase; infants; inspiratory; life; lung; lung function; lung volume; mechanics; muscle; patients; pressure; preterm; pulmonary; resistance; scoliosis; system; ventilation; volume; wall; years cache: cord-024183-1mrdjc39.txt plain text: cord-024183-1mrdjc39.txt item: #41 of 68 id: cord-026005-f2khcjdy author: López, Alfonso title: Respiratory System, Mediastinum, and Pleurae date: 2017-02-17 words: 57351 flesch: 32 summary: Lung disease can have profound systemic effects when cytokines, produced locally during necrosis or inflammation, are released into circulation. Alveolar filling disorders are a heterogeneous group of lung diseases characterized by accumulation of various chemical compounds in the alveolar lumens. keywords: acute; air; alveolar; alveoli; animals; bacterial; beings; blood; bovine; bronchi; bronchopneumonia; cases; cats; cattle; cause; cavity; cells; chronic; common; disease; dogs; edema; emphysema; exudate; fibrosis; fig; fluid; horses; human; hyperplasia; infection; inflammation; injury; interstitial; lesions; lungs; macrophages; mucosa; nasal; necrosis; neutrophils; pigs; pneumonia; pneumonocytes; present; pulmonary; result; rhinitis; syndrome; system; tissue; type; viral; virus cache: cord-026005-f2khcjdy.txt plain text: cord-026005-f2khcjdy.txt item: #42 of 68 id: cord-034294-ti1cc24m author: Wang, Cuixue title: Progress in the mechanism and targeted drug therapy for COPD date: 2020-10-27 words: 16542 flesch: 29 summary: COPD patients suffer from oxidative stress caused by the inhalation of cigarette smoke (CS) or harmful substances which causes an accumulation of pulmonary inflammatory cells (neutrophils, macrophages), leading to large numbers of reactive oxygen species (ROS). 221 Clinically, they are used for long-term treatment of chronic inflammatory lung diseases such as COPD. keywords: activation; airway; akt; anti; cells; chronic; copd; copd patients; development; disease; effects; expression; factor; growth; inflammation; inhibitors; kinase; lung; neutrophils; oxidative; pathway; patients; pi3k; production; protein; pulmonary; receptor; regulating; role; signalling; stress; tgf; trx cache: cord-034294-ti1cc24m.txt plain text: cord-034294-ti1cc24m.txt item: #43 of 68 id: cord-034406-i1hbx3pz author: Matthews, Abigail A. title: Developing inhaled protein therapeutics for lung diseases date: 2020-10-30 words: 8744 flesch: 37 summary: As only one medicine Respimat uses SMI, its suitability for protein drug delivery is not clear. It is probable that HYDRA nebulisers may be developed for pulmonary protein drug delivery. keywords: aerosol; aggregation; delivery; diseases; drug; excipients; formulation; inhalation; insulin; lung; nebulisers; particles; protein; stability; studies; therapeutics; use cache: cord-034406-i1hbx3pz.txt plain text: cord-034406-i1hbx3pz.txt item: #44 of 68 id: cord-035258-nff6gfik author: Tanner, Tristan George title: Pulmonary Complications of Cardiac Surgery date: 2020-11-11 words: 4447 flesch: 23 summary: Current trends in preoperative, intraoperative, and postoperative care of the adult cardiac surgery patient Incidence and hospital stay for cardiac and pulmonary complications after abdominal surgery Prediction of postoperative pulmonary complications in a population-based surgical cohort Prospective external validation of a predictive score for postoperative pulmonary complications Bronchial artery perfusion during cardiopulmonary bypass does not prevent ischemia of the lung in piglets: assessment of bronchial artery blood flow with fluorescent microspheres Lung ischemiareperfusion injury: a molecular and clinical view on a complex pathophysiological process The effect of pulsatile cardiopulmonary bypass on lung function in elderly patients Lung protection in cardio-pulmonary bypass Pulmonary artery perfusion versus no pulmonary perfusion during cardiopulmonary bypass in patients with COPD: a randomised clinical trial No-reflow phenomenon Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials A systematic review of biocompatible cardiopulmonary bypass circuits and clinical outcome Leukocyte depletion during CPB: effects on inflammation and lung function Protamine dosage effects on complement activation and sonoclot coagulation analysis after cardiac surgery Serious anaphylactic reactions due to protamine sulfate: a systematic literature review Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgery Three cases of anaphylaxis to protamine: management of anticoagulation reversal Acute intracardiac thrombosis and pulmonary thromboembolism after cardiopulmonary bypass: a systematic review of reported cases EACTS/ EACTA guidelines on patient blood management for adult cardiac surgery Reoperation for bleeding in patients undergoing coronary artery bypass surgery Six-month outcomes after restrictive or liberal transfusion for cardiac surgery Patient blood management in cardiac surgery The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested casecontrol study The role of neutrophils in the pathogenesis of transfusion-related acute lung injury Neutrophil adhesion molecule expression during cardiopulmonary bypass with bubble and membrane oxygenators Postoperative cardiac surgical care: an alternative approach Radiographic pulmonary abnormalities after different types of cardiac surgery Prevalence and clinical course of pleural effusions at 30 days after coronary artery and cardiac surgery Electrophysiological evaluation of phrenic nerve injury during cardiac surgery-a prospective, controlled, clinical study Phrenic nerve dysfunction after cardiac operations: electrophysiologic evaluation of risk factors Pneumonia after cardiac surgery: experience of the National Institutes of Health/ Canadian Institutes of Health research cardiothoracic surgical trials network The impact of nosocomial infections on patient outcomes following cardiac surgery Prolonged ventilation post cardiac surgery-tips and pitfalls of the prediction game Predictors of prolonged mechanical ventilation after open heart surgery Prolonged mechanical ventilation after cardiac surgery: outcome and predictors Incidence and predictors of ARDS after cardiac surgery Prevalence of acute respiratory distress syndrome after cardiac surgery Pulmonary dysfunction after cardiac surgery Atelectasis and gas exchange impairment during enflurane/nitrous oxide anaesthesia Influence of age on atelectasis formation and gas exchange impairment during general anaesthesia Atelectasis and gas exchange after cardiac surgery Continuous positive airway pressure versus noninvasive pressure support ventilation to treat atelectasis after cardiac surgery Prophylactic respiratory physiotherapy after cardiac surgery: systematic review Pleural effusions following cardiac surgery: prevalence, risk factors, and clinical features Coronary artery bypass graft readmission rates and risk factors-a retrospective cohort study The post-pericardiotomy syndrome Contemporary features, risk factors, and prognosis of the post-pericardiotomy syndrome Clinical features associated with adverse events in patients with postpericardiotomy syndrome following cardiac surgery Characteristics of pleural effusions in acute idiopathic pericarditis and post-cardiac injury syndrome Pleural effusions in acute idiopathic pericarditis and postcardiac injury syndrome | Ovid Early, dedicated follow-up and treatment of pleural effusions enhance the recovery rate after open cardiac surgery: results from a randomized, clinical trial Six-minute walk test as a prognostic tool in stable coronary heart disease: data from the heart and soul study Outcome after procedures for retained blood syndrome in coronary surgery Pneumothorax, chylothorax, hemothorax, and fibrothorax. keywords: acute; artery; blood; bypass; complications; injury; lung; patients; pulmonary; surgery; syndrome cache: cord-035258-nff6gfik.txt plain text: cord-035258-nff6gfik.txt item: #45 of 68 id: cord-253722-6jsaxirt author: Lan, Yanqiu title: Danhong injection in the treatment of idiopathic pulmonary fibrosis: A protocol for systematic review and meta-analysis date: 2020-09-11 words: 1864 flesch: 39 summary: Short-length version Model-based meta-analysis on the efficacy of pharmacological treatments for idiopathic pulmonary fibrosis Updated evaluation of the safety, efficacy and tolerability of pirfenidone in the treatment of idiopathic pulmonary fibrosis Is pirfenidone effective for idiopathic pulmonary fibrosis? Systematic review and network meta-analysis of idiopathic pulmonary fibrosis treatments Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2 Probing into the mechanism of alkaline citrus extract promoted apoptosis in pulmonary fibroblasts of bleomycin-induced pulmonary fibrosis mice Effectiveness and safety of Chinese medicine for idiopathic pulmonary fibrosis: a systematic review and meta-analysis Danhong injection in cardiovascular and cerebrovascular diseases: pharmacological actions, molecular mechanisms, and therapeutic potential Ability to suppress TGF-b-activated myofibroblast differentiation distinguishes the anti-pulmonary fibrosis efficacy of two danshen-containing Chinese herbal medicine prescriptions Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation key: cord-253722-6jsaxirt authors: Lan, Yanqiu; Wu, Dezhi; Jin, Yunrui; Shui, Min; Fan, Xianjun title: Danhong injection in the treatment of idiopathic pulmonary fibrosis: A protocol for systematic review and meta-analysis date: 2020-09-11 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000022016 sha: doc_id: 253722 cord_uid: 6jsaxirt BACKGROUND: keywords: analysis; fibrosis; injection; pulmonary; treatment cache: cord-253722-6jsaxirt.txt plain text: cord-253722-6jsaxirt.txt item: #46 of 68 id: cord-255519-tcobane8 author: Bartels, Matthew N. title: Acute Medical Conditions: Cardiopulmonary Disease, Medical Frailty, and Renal Failure date: 2020-10-02 words: 20003 flesch: 28 summary: Guidelines for cardiac rehabilitation and secondary prevention programs Core components of cardiac rehabilitation/secondary prevention programs: a statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit Acute medical rehabilitation Physical medicine and rehabilitation patient centered care Essential physical medicine and rehabilitation Evaluation of pulmonary function and exercise performance by cardiopulmonary exercise testing before and after lung transplantation Improving the quality of quality improvement projects Canadian Study of Health and Aging Working Group: Disability and frailty among elderly Canadians: a comparison of six surveys Insulin-like growth factor I and interleukin-6 contribute synergistically to disability and mortality in older women Core competencies for cardiac rehabilitation/secondary prevention professionals: 2010 update: position statement of the American Association of Cardiovascular and Pulmonary Rehabilitation Physical activity and public health: updated recommendation for adults from the Objectively measured sedentary time may predict insulin resistance independent of moderate-and vigorous-intensity physical activity The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians The effects of training on heart rate; a longitudinal study Medical director responsibilities for outpatient cardiac rehabilitation/secondary prevention programs: 2012 update: a statement for health care professionals from the American Association for Cardiovascular and Pulmonary Rehabilitation and the American Heart Association Rehabilitation for hospital-associated deconditioning The long-term psychological effects of daily sedative interruption on critically ill patients Exercise testing in asymptomatic adults: a statement for professionals from the American Heart Association Council on Clinical Cardiology, Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American Association of Cardiovascular and Pulmonary Rehabilitation IGF-1, the cross road of the nutritional, inflammatory and hormonal pathways to frailty Uremic myopathy limits aerobic capacity in hemodialysis patients Coronary heart-disease and physical activity of work Coronary heart-disease and physical activity of work Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference European Respiratory Society statement on pulmonary rehabilitation Clinical competency guidelines for pulmonary rehabilitation professionals: American Association of Cardiovascular and Pulmonary Rehabilitation Position Statement Cardiac rehabilitation after myocardial infarction. Diagnostic and statistical manual of mental disorders The national medical series for independent study: anatomy Culture of early mobility in mechanically ventilated patients Core components of cardiac rehabilitation/secondary prevention programs: a statement for healthcare professionals from the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation Writing Group Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle Physical activity and mortality related to obesity and functional status in older adults in Spain Developing a rural transitional care community case management program using clinical nurse specialists Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit Acute medical rehabilitation Grabois M, editor: Physical medicine and rehabilitation: the complete approach Physical medicine and rehabilitation patient centered care Pulmonary rehabilitation Rehabilitation management of lung volume reduction surgery Evaluation of pulmonary function and exercise performance by cardiopulmonary exercise testing before and after lung transplantation Improving the quality of quality improvement projects Lower limb skeletal muscle function after 6 wk of bed rest Post-traumatic stress disorder symptoms after acute lung injury: a 2-year prospective longitudinal study Bed rest in heart trouble Effectiveness and safety of a home-based cardiac rehabilitation programme of mixed surveillance in patients with ischemic heart disease at moderate cardiovascular risk: a randomised, controlled clinical trial A perfect storm: care transitions for vulnerable older adults discharged home from the emergency department without a hospital admission Canadian Study of Health and Aging Working Group: Disability and frailty among elderly Canadians: a comparison of six surveys Electrophysiologic studies in the denervated transplanted human heart. keywords: activity; american; association; cardiac; cardiopulmonary; care; chronic; clinical; disease; exercise; failure; following; frailty; health; heart; heart disease; intensity; lung; mobilization; patients; physical; prevention; program; pulmonary; rate; rehabilitation; risk; syndrome; training; transplantation cache: cord-255519-tcobane8.txt plain text: cord-255519-tcobane8.txt item: #47 of 68 id: cord-272034-fvii5nsv author: McNaughton, Amanda title: Taking Charge: A Proposed Psychological Intervention to Improve Pulmonary Rehabilitation Outcomes for People with COPD date: 2020-09-11 words: 3314 flesch: 37 summary: 1,2 Furthermore, psychological factors can influence uptake and outcomes of the most effective therapy available for people with COPD -pulmonary rehabilitation (PR). 9, 10 The Take Charge intervention was tested in the early community phase of stroke rehabilitation, 2-16 weeks after acute stroke, in addition to usual community stroke rehabilitation. keywords: charge; copd; patients; people; pulmonary; rehabilitation; stroke cache: cord-272034-fvii5nsv.txt plain text: cord-272034-fvii5nsv.txt item: #48 of 68 id: cord-273149-b1qsnxr1 author: Ramjug, Sheila title: ERS International Congress, Madrid, 2019: highlights from the Pulmonary Vascular Diseases Assembly date: 2020-10-13 words: 5575 flesch: 40 summary: A prospective study comparing the repeatability and sensitivity to change of non-invasive endpoints in pulmonary arterial hypertension: the RESPIRE study Intravenous treprostinil as an add-on therapy in patients with pulmonary arterial hypertension Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension Serum endostatin as a genetically-influenced biomarker in PAH Clinical value of asymmetrical dimethylarginine detection in patients with connective tissue disease-associated pulmonary arterial hypertension Asymmetric dimethylarginine at sea level is a predictive marker of hypoxic pulmonary arterial hypertension at high altitude Asymmetric dimethyl-L-arginine is a biomarker for disease stage and follow-up of pulmonary hypertension associated with congenital heart disease Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension Asymmetric dimethylarginine is increased in chronic thromboembolic pulmonary hypertension Asymmetric dimethylarginine (ADMA) to monitor treatments of pulmonary hypertension ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension Red cell distribution width outperforms other potential circulating biomarkers in predicting survival in idiopathic pulmonary arterial hypertension Cell free haemoglobin and pulmonary artery endothelial cell dysfunction Platelets and pulmonary arterial hypertension (PAH) Platelets and chronic thromboembolic pulmonary hypertension Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension Iron deficiency in chronic thromboembolic pulmonary hypertension Long noncoding RNAs: past, present, and future Discerning functional hierarchies of microRNAs in pulmonary hypertension MiR-1-5p targets TGF-βR1 and is suppressed in the hypertrophying hearts of rats with pulmonary arterial hypertension Long non-coding RNA H19 in right ventricular failure associated with pulmonary arterial hypertension Differential expression of miRNAs present in plasma and contained within circulating microparticles in precapillary pulmonary hypertension Conflict of interest: S. Ramjug reports nonfinancial support from Janssen, and grants and nonfinancial support from Actelion, during the writing of the manuscript. A prespecified subgroup analysis of a double-blind randomized clinical trial (INSTAGE) Changes in biomarkers in patients with idiopathic pulmonary fibrosis (IPF) treated with nintedanib and sildenafil Nintedanib has acute pulmonary vasodilatory effects in transgenic Fra2 mice with spontaneous progressive pulmonary hypertension and lung fibrosis Pulmonary hypertension in chronic lung disease and hypoxia Predicting survival in patients with pulmonary arterial hypertension: the REVEAL risk score calculator 2.0 and comparison with ESC/ERS-based risk assessment strategies Retrospective validation of the REVEAL 2.0 risk score with the Australian and New Zealand Pulmonary Hypertension Registry cohort A dynamic prognostic model to predict survival and determine treatment goals in pulmonary arterial hypertension (PAH): the EFORT study Risk stratification of pulmonary arterial hypertension (PAH) associated with adult congenital heart disease (ACHD) keywords: disease; embolism; hypertension; pah; patients; pulmonary; risk; study; survival cache: cord-273149-b1qsnxr1.txt plain text: cord-273149-b1qsnxr1.txt item: #49 of 68 id: cord-278846-nqj7ctk3 author: Ogger, Patricia P. title: Macrophage metabolic reprogramming during chronic lung disease date: 2020-11-12 words: 10150 flesch: 16 summary: The iron-y of iron overload and iron deficiency in chronic obstructive pulmonary disease Increased iron sequestration in alveolar macrophages in chronic obtructive pulmonary disease Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages Mitochondrial dysfunction in macrophages: A key to defective bacterial phagocytosis in COPD Alveolar macrophage immunometabolism and lung function impairment in smoking and chronic obstructive pulmonary disease Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis The MIF antagonist ISO-1 attenuates corticosteroid-insensitive inflammation and airways hyperresponsiveness in an ozone-induced model of COPD Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model Mitochondrial iron chelation ameliorates cigarette smokeinduced bronchitis and emphysema in mice Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine Progress in understanding mucus abnormalities in cystic fibrosis airways Lung inflammation in cystic fibrosis: pathogenesis and novel therapies Inflammation in cystic fibrosis: an update Inflammation and its genesis in cystic fibrosis Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis Inflammation, infection, and pulmonary function in infants and young children with cystic fibrosis Azithromycin reduces exaggerated cytokine production by M1 alveolar macrophages in cystic fibrosis Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/-mice CFTR-dependent defect in alternatively-activated macrophages in cystic fibrosis Characterization of macrophage activation states in patients with cystic fibrosis Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors Tgf-β1 inhibits Cftr biogenesis and prevents functional rescue of ΔF508-Cftr in primary differentiated human bronchial epithelial cells Series 'matrix metalloproteinases in lung health and disease': the role of matrix metalloproteinases in cystic fibrosis lung disease Glutathione and infection Systemic deficiency of glutathione in cystic fibrosis Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients Transforming growth factorβ activation in the lung: Focus on fibrosis and reactive oxygen species Impaired defenses of neonatal mouse alveolar macrophage with cftr deletion are modulated by glutathione and TGFβ1 Human cystic fibrosis macrophages have defective calciumdependent protein kinase C activation of the NADPH oxidase, an effect augmented by burkholderia cenocepacia Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection Pseudomonas aeruginosa utilizes host-derived itaconate to redirect its metabolism to promote biofilm formation Pulmonary pathogens adapt to immune signaling metabolites in the airway Lipid metabolism in cystic fibrosis Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis Metabolic reprograming of cystic fibrosis macrophages via the IRE1α arm of the unfolded protein response results in exacerbated inflammation Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis Oral DHA supplementation in ΔF508 homozygous cystic fibrosis patients Bioavailability and safety of a high dose of docosahexaenoic acid triacylglycerol of algal origin in cystic fibrosis patients: a randomized, controlled study Effect of an 8-month treatment with ω-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis Idiopathic pulmonary fibrosis: Guidelines for diagnosis and clinical management have advanced from consensus-based in 2000 to evidence-based in 2011 Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis: An integral model Macrophages: Friend or foe in idiopathic pulmonary fibrosis? Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis Multiplex protein profiling of bronchoalveolar lavage in idiopathic pulmonary fibrosis and hypersensitivity pneumonitis Metalloproteinases in idiopathic pulmonary fibrosis Accumulation of damaged mitochondria in alveolar macrophages with reduced OXPHOS related gene expression in IPF Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis Glucose transporter-1 distribution in fibrotic lung disease: Association with [18F]-2-fluoro-2-deoxyglucose-PET scan uptake, inflammation, and neovascularization Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells Succinate: a metabolic signal in inflammation Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase to modulate intracellular succinate levels Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation Itaconate controls the severity of pulmonary fibrosis Reactive oxygen species as signaling molecules in the development of lung fibrosis Macrophages and iron metabolism The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size Delta-like 4 induces Notch signaling in macrophages: implications for inflammation Increased production of the potent oxidant peroxynitrite in the lungs of patients with idiopathic pulmonary fibrosis Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis Iron laden macrophages in idiopathic pulmonary fibrosis: the telltale of occult alveolar hemorrhage? Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation The transferrin receptor CD71 delineates functionally distinct airway macrophage subsets during idiopathic pulmonary fibrosis TOLLIP, MUC5B, and the response to N-acetylcysteine among individuals with idiopathic pulmonary fibrosis Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial Metformin: an old dog with a new trick? Metformin attenuates lung fibrosis development via NOX4 suppression Metformin reverses established lung fibrosis in a bleomycin model Metformin does not affect clinically relevant outcomes in patients with idiopathic pulmonary fibrosis Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages SARS-CoV-2 and viral sepsis: observations and hypotheses Complex immune dysregulation in COVID-19 patients with severe respiratory failure COVID-19: consider cytokine storm syndromes and immunosuppression The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of monocyte-derived macrophages and dendritic cells The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice Interaction of influenza virus with mouse macrophages Host defense mechanisms against influenza virus: interaction of influenza virus with murine macrophages in vitro Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages Pro-and anti-inflammatory cytokines in tuberculosis: a two-edged sword in TB pathogenesis Mycobacterial survival strategies in the phagosome: defence against host stresses Intracellular trafficking in mycobacterium tuberculosis and mycobacterium avium-infected macrophages HIF-1α Is an essential mediator of IFN-γ-dependent immunity to mycobacterium tuberculosis Infection with mycobacterium tuberculosis induces the Warburg effect in mouse lungs Cutting edge: mycobacterium tuberculosis induces aerobic glycolysis in human alveolar macrophages that is required for control of intracellular bacillary replication Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis Mycobacterium tuberculosis limits host glycolysis and IL-1β by restriction of PFK-M via MicroRNA-21 Fumarase deficiency causes protein and metabolite succination and intoxicates mycobacterium tuberculosis An essential bifunctional enzyme in Mycobacterium tuberculosis for itaconate dissimilation and leucine catabolism The effect of the host's iron status on tuberculosis Hereditary hemochromatosis results in decreased iron acquisition and growth by Mycobacterium tuberculosis within human macrophages A major role for ferroptosis in mycobacterium tuberculosis-induced cell death and tissue necrosis Small RNA profiling in mycobacterium tuberculosis identifies mrsi as necessary for an anticipatory iron sparing response PPAR-α activation mediates innate host defense through induction of TFEB and lipid catabolism Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny Mycobacterium tuberculosis induces the MIR-33 locus to reprogram autophagy and host lipid metabolism In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis Mycobacterium bovis bacillus Calmette-Guérin infection induces TLR2-dependent peroxisome proliferator-activated receptor γ expression and activation: functions in inflammation, lipid metabolism, and pathogenesis Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor γ linking mannose receptor recognition to regulation of immune responses Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice Statin therapy reduces the mycobacterium tuberculosis burden in human macrophages and in mice by enhancing autophagy and phagosome maturation Furthermore, post birth and during maturation, circulating monocytes do not significantly contribute to lung macrophage populations at homoeostasis 18 . keywords: acid; activation; airway; alveolar; ams; asthma; cells; chronic; copd; disease; fibrosis; human; infection; inflammation; ipf; iron; lung; macrophages; metabolic; patients; phenotype; production; pulmonary; tuberculosis cache: cord-278846-nqj7ctk3.txt plain text: cord-278846-nqj7ctk3.txt item: #50 of 68 id: cord-287544-n32iscmr author: Solaimanzadeh, Isaac title: Nifedipine and Amlodipine Are Associated With Improved Mortality and Decreased Risk for Intubation and Mechanical Ventilation in Elderly Patients Hospitalized for COVID-19 date: 2020-05-12 words: 5449 flesch: 37 summary: CCB patients were also significantly less likely to undergo intubation and mechanical ventilation. CCB patients were also significantly less likely to undergo intubation and mechanical ventilation. keywords: amlodipine; ccb; covid-19; disease; group; hypertension; nifedipine; patients; treatment cache: cord-287544-n32iscmr.txt plain text: cord-287544-n32iscmr.txt item: #51 of 68 id: cord-290006-63sa00ju author: Ko, Jane P. title: Approach to Peribronchovascular Disease on CT date: 2018-12-20 words: 6396 flesch: 31 summary: Two radiologic patterns with a different prognosis Comparison of computed tomographic findings in pulmonary mucormycosis and invasive pulmonary aspergillosis Chronic pulmonary paracoccidioidomycosis (South American blastomycosis): High-resolution CT findings in 41 patients Radiographic and CT features of viral pneumonia Invasive pulmonary aspergillosis in acute leukemia: Characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis Role of procalcitonin in the management of infected patients in the intensive care unit A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the Diagnostic accuracy of xpert test in tuberculosis detection: A systematic review and metaanalysis Recent advances in diagnosing chronic pulmonary aspergillosis Beta-D-glucan testing is important for diagnosis of invasive fungal infections Role of serological tests in the diagnosis of mold infections Imaging of pulmonary vasculitis Pulmonary involvement in Churg-Strauss syndrome: An analysis of CT, clinical, and pathologic findings CT features of vasculitides based on the 2012 International Chapel Hill Consensus Conference Revised Classification The lung in systemic vasculitis: Radiological patterns and differential diagnosis Granulomatosis with polyangiitis (Wegener): Clinical aspects and treatment Pulmonary manifestations of wegener granulomatosis: CT findings in 57 patients and a review of the literature Thoracic manifestation of Churg-Strauss syndrome: Radiologic and clinical findings Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management Churg-Strauss syndrome: High resolution CT and pathologic findings Eosinophilic lung diseases: Diagnostic accuracy of thin-section CT in 111 patients Churg-Strauss syndrome: The spectrum of pulmonary CT findings in 17 patients Transbronchial lung biopsy for the diagnosis of IgG4-related lung disease IgG4-related Lung disease associated with autoimmune hemolytic anemia: Serial high-resolution CT findings in 22 patients Pneumonitis in non-small cell lung cancer patients receiving immune checkpoint immunotherapy: Incidence and risk factors Cryptogenic organizing pneumonia: CT findings in 43 patients Serial chest CT in cryptogenic organizing pneumonia: keywords: associated; disease; findings; infection; lung; lymphoma; nodules; organizing; patients; peribronchovascular; pneumonia; pulmonary cache: cord-290006-63sa00ju.txt plain text: cord-290006-63sa00ju.txt item: #52 of 68 id: cord-293613-xnos7iud author: Ritchie, Andrew I. title: Definition, Causes, Pathogenesis, and Consequences of Chronic Obstructive Pulmonary Disease Exacerbations date: 2020-08-12 words: 7490 flesch: 23 summary: trial Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study Lymphocyte subsets in experimental rhinovirus infection in chronic obstructive pulmonary disease A systematic review of diagnostic biomarkers of COPD exacerbation C-reactive protein in outpatients with acute exacerbation of COPD: its relationship with microbial etiology and severity Serum inflammatory biomarkers and clinical outcomes of COPD exacerbation caused by different pathogens Procalcitonin to guide antibiotic administration in COPD exacerbations: a meta-analysis High plasma brain natriuretic peptide levels in stable COPD without pulmonary hypertension or cor pulmonale Calistru PI. Eur Respir The role of the bacterial microbiome in lung disease Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease Moraxella catarrhalis in chronic obstructive pulmonary disease Host-pathogen interaction during pneumococcal infection in patients with chronic obstructive pulmonary disease Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease Rhinovirus infection induces degradation of antimicrobial peptides and secondary bacterial infection in chronic obstructive pulmonary disease Rhinovirus exposure impairs immune responses to bacterial products in human alveolar macrophages Viral inhibition of bacterial phagocytosis by human macrophages: redundant role of CD36 Human rhinovirus impairs the innate immune response to bacteria in alveolar macrophages in chronic obstructive pulmonary disease Rhinovirus attenuates non-typeable Hemophilus influenzaestimulated IL-8 responses via TLR2-dependent degradation of IRAK-1 Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment COPD exacerbation severity and frequency is associated with impaired macrophage efferocytosis of eosinophils Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials Blood eosinophils and inhaled corticosteroid/long-acting b-2 agonist efficacy in COPD Viral infections in allergy and immunology: how allergic inflammation influences viral infections and illness Airway eosinophilia in chronic bronchitis during exacerbations Oxidative and nitrosative stress and histone deacetylase-2 activity in exacerbations of chronic obstructive pulmonary disease Neutrophil adhesion molecules in experimental rhinovirus infection in COPD Altered macrophage function in chronic obstructive pulmonary disease Impaired alveolar macrophage response to Haemophilus antigens in chronic obstructive lung disease Differential effects of p38, MAPK, PI3K or rho kinase inhibitors on bacterial phagocytosis and efferocytosis by macrophages in COPD Elastaseand LPS-exposed mice display altered responses to rhinovirus infection Analysis of viral infection and biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease The expression of IL-6, TNF-a, and MCP-1 in respiratory viral infection in acute exacerbations of chronic obstructive pulmonary disease The use of serum procalcitonin as a diagnostic and prognostic biomarker in chronic obstructive pulmonary disease exacerbations: a literature review update A two-stage logistic model based on the measurement of pro-inflammatory cytokines in bronchial secretions for assessing bacterial, viral, and noninfectious origin of COPD exacerbations Diagnosing viral and bacterial respiratory infections in acute COPD exacerbations by an electronic nose: a pilot study Biomarkers for predicting COPD exacerbations Fibrinogen and COPD: now what? keywords: airway; bacterial; chronic; copd; disease; exacerbations; infection; inflammation; patients; respiratory; response; rhinovirus; sputum; studies; study cache: cord-293613-xnos7iud.txt plain text: cord-293613-xnos7iud.txt item: #53 of 68 id: cord-305838-i0ck2oo0 author: Kouri, Andrew title: CHEST Reviews: Addressing reduced laboratory-based pulmonary function testing during a pandemic date: 2020-07-08 words: 4890 flesch: 28 summary: [17] [18] [19] [20] Access to reliable pulmonary function data is particularly critical for lung transplant patients when weekly monitoring with spirometry is the gold standard care during the first 3 months post-transplant when the risk of acute graft rejection is highest. In asthma care, mHealth applications supporting patient self-management through education, medication reminders, symptom monitoring, and action plan provision have been shown to improve asthma control, medication and action plan adherence, and quality of life. keywords: asthma; copd; diagnosis; function; lung; management; oscillometry; patients; pulmonary; spirometry; testing cache: cord-305838-i0ck2oo0.txt plain text: cord-305838-i0ck2oo0.txt item: #54 of 68 id: cord-312978-i41l4mtx author: El Fakiri, Karima title: Hydropneumothorax Revealing a Pneumoblastoma in Children date: 2020-09-09 words: 1635 flesch: 42 summary: Regarding the localization, the right lung is more frequently affected by pulmonary blastoma than the left, which is consistent with a previous study involving adult patients [6] . Case Reports in Pediatrics Finally, pulmonary blastoma is a rare tumor which must be in mind even if we have no specific signs. keywords: blastoma; right; tumor; type cache: cord-312978-i41l4mtx.txt plain text: cord-312978-i41l4mtx.txt item: #55 of 68 id: cord-314106-r3axl3w1 author: Porembskaya, Olga title: Pulmonary Artery Thrombosis: A Diagnosis That Strives for Its Independence date: 2020-07-18 words: 7558 flesch: 36 summary: In this cohort of patients, the combination of PA thrombosis with DVT was registered only in 15-23% and primary PA thrombosis in more than 75% [3, 15] . In this review, we discuss potential mechanisms of PA thrombosis in situ. keywords: activation; branches; cells; endothelial; factor; hypoxia; pa thrombosis; patients; platelet; protein; pulmonary; thrombin; thrombosis; venous cache: cord-314106-r3axl3w1.txt plain text: cord-314106-r3axl3w1.txt item: #56 of 68 id: cord-320447-nq9f1gmu author: Lins, Muriel title: Assessment of small pulmonary blood vessels in COVID-19 patients using HRCT date: 2020-07-25 words: 2813 flesch: 38 summary: Compared to healthy volunteers, COVID-19 patients showed significant reduction in BV5 (pulmonary blood volume contained in blood vessels of <5 mm(2)) expressed as BV5/(Total pulmonary blood volume) (p<0.0001), and significant increases in BV5-10 and BV 10 (pulmonary blood volumes contained in vessels between 5 and 10 mm(2) and above 10 mm(2), respectively) (p<0.0001). Compared to healthy volunteers, COVID-19 patients showed significant reduction in BV5 (pulmonary blood volume contained in blood vessels of <5 mm 2 ) expressed as BV5/(Total pulmonary blood volume) (p<0.0001), and significant increases in BV5-10 and BV 10 (pulmonary blood volumes contained in vessels between 5 and 10 mm 2 and above 10 mm 2 , respectively) (p<0.0001). keywords: blood; covid-19; patients; vascular; vessels; volume cache: cord-320447-nq9f1gmu.txt plain text: cord-320447-nq9f1gmu.txt item: #57 of 68 id: cord-320959-sgdqhtns author: Lee, Hanjun title: Vitamin E Acetate as Linactant in the Pathophysiology of EVALI date: 2020-08-12 words: 6726 flesch: 25 summary: Update: Characteristics of a Nationwide Outbreak of E-cigarette, or Vaping, Product Use-Associated Lung Injury -United States Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin -Final Report Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury -United States Imaging of vaping-associated lung disease Syndromic surveillance for e-cigarette, or vaping, product use-associated lung injury Tolerance to hypothermic and antinoceptive effects of ∆9-tetrahydrocannabinol (THC) vapor inhalation in rats Lasting effects of repeated ∆9-tetrahydrocannabinol vapour inhalation during adolescence in male and female rats tree-in-bloom: Severe acute lung injury induced by vaping cannabis oil Pathology of vaping-associated lung injury More on the Pathology of Vaping-Associated Lung Injury Pulmonary lipid-laden macrophages and 5 vaping Vitamin E acetate in bronchoalveolarlavage fluid associated with EVALI A history of vitamin e Vitamin E, antioxidant and nothing more Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs The molecular basis of vitamin E retention: Structure of human α-tocopherol transfer protein α-Tocopherol transfer protein stimulates the secretion of α-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway α-Tocopherol transfer protein mediates 20 protective hypercapnia in murine ventilator-induced lung injury Safety assessment of the substance α-tocopherol acetate for use in food contact materials All-rac-α-Tocopherol Acetate Is a Better Vitamin E Source than all-rac-α-Tocopherol Succinate for Broilers The distribution and relative hydrolysis of tocopheryl acetate in the different matrices coexisting in the lumen of the 5 small intestine during digestion could explain its low bioavailability Supercritical fluid-aerosolized vitamin E pretreatment decreases leak in isolated oxidant-perfused rat lungs Aerosol-administered α-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally Hydrolysis of RRR-αtocopheryl acetate (vitamin E acetate) in the skin and its UV protecting activity (an in vivo 15 study with the rat) Characterization of antioxidant activities of pulmonary surfactant mixtures Type II pneumocytes secrete vitamin E 20 together with surfactant lipids Oxidative stress and antioxidants at biosurfaces: plants, skin, and respiratory tract surfaces Vitamin E: Non-antioxidant roles The rise, the fall and the renaissance of Vitamin E Vitamin E: Emerging aspects and new directions Potential for release of pulmonary toxic ketene from vaping pyrolysis of Vitamin E acetate Hydrogen Bonding between Tetrahydrocannabinol and Vitamin E Acetate in Unvaped, Aerosolized, and Condensed 10 Aerosol e-Liquids Interaction of vitamin E with saturated phospholipid bilayers Modulated phases of phospholipid bilayers induced by tocopherols Targeting cholesterol homeostasis in lung diseases A Unique Case of Secondary Pulmonary Alveolar Proteinosis Following E-Cigarette, or Vaping, Product Use-Associated Lung Injury (EVALI) Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction Calorimetric evidence for the liquid-crystalline state of lipids in a biomembrane Lipid droplet functions beyond energy storage Nonalcoholic fatty liver disease impairs the cytochrome P-450-dependent metabolism of α-tocopherol (vitamin E) Vaping-Associated Acute 10 Respiratory Failure Due to Acute Lipoid Pneumonia However, Vitamin E acetate, given the additional ester moiety, is deprived of the antioxidative property and is markedly more thermostable. keywords: acetate; cholesterol; e acetate; evali; lipid; lung; patients; phase; tocopherol; vaping; vitamin; vitamin e cache: cord-320959-sgdqhtns.txt plain text: cord-320959-sgdqhtns.txt item: #58 of 68 id: cord-322756-ouvn71r9 author: Chow, Michael Y.T. title: Inhaled RNA Therapy: From Promise to Reality date: 2020-09-04 words: 7289 flesch: 36 summary: In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. keywords: administration; cell; delivery; gene; lung; mrna; naked; pulmonary; rna; sirna; studies; table; therapy; transfection; use; vectors cache: cord-322756-ouvn71r9.txt plain text: cord-322756-ouvn71r9.txt item: #59 of 68 id: cord-322919-5ty35rsy author: Busana, Mattia title: Non‐invasive hemodynamic profile of early COVID‐19 infection date: 2020-10-28 words: 2511 flesch: 44 summary: Thus, we would have expected to find signs of increased pulmonary pressure, but this was not the case. Furthermore, Sonzogni et al. (2020) described severe alterations in hepatic blood flow with massive portal vessel dilations in autopsies from COVID-19 patients. keywords: covid-19; patients; svri cache: cord-322919-5ty35rsy.txt plain text: cord-322919-5ty35rsy.txt item: #60 of 68 id: cord-323566-jck799zq author: Cheung, Oi-Yee title: Acute Lung Injury date: 2017-11-05 words: 8319 flesch: 34 summary: Other histologic features of acute lung injury include intraalveolar fibrin, organization, interstitial edema, and reactive pneumocytes. Diffuse alveolar damage and other histologic features of acute lung injury are nonspecific as to etiology, and once identified require the pathologist to search the biopsy for further features that may help identify a specific etiology. keywords: acute; alveolar; biopsy; cases; cause; dad; diffuse; disease; fig; infection; injury; lung; patients; pneumonia; pulmonary; syndrome cache: cord-323566-jck799zq.txt plain text: cord-323566-jck799zq.txt item: #61 of 68 id: cord-325461-q8igdvq4 author: Ryan, Donal title: Pulmonary vascular dysfunction in ARDS date: 2014-08-22 words: 6631 flesch: 37 summary: We know from studies of major pulmonary embolism, that a normal right ventricle cannot acutely generate pulmonary pressures greater than 40 mmHg (mean) and quickly fails in this clinical context [64] . Pulmonary arterial pressure, pulmonary vascular resistance and transpulmonary gradient (TPG) depend not alone on the intrinsic properties of the pulmonary vascular bed but are also strongly influenced by cardiac output, airway pressures and lung volumes. keywords: acute; ards; lung; mortality; patients; pressure; pulmonary; resistance; right; syndrome; vascular cache: cord-325461-q8igdvq4.txt plain text: cord-325461-q8igdvq4.txt item: #62 of 68 id: cord-329442-ycj6sf6z author: Perotin, Jeanne‐Marie title: Detection of multiple viral and bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: A pilot prospective study date: 2013-02-27 words: 3901 flesch: 32 summary: The present results demonstrated chronic obstructive pulmonary disease patients infected by two respiratory viruses therefore suggesting a potential intrinsic susceptibility to particular triggers of acute exacerbation of chronic obstructive pulmonary disease [Seemungal et al., 2001] . key: cord-329442-ycj6sf6z authors: Perotin, Jeanne‐Marie; Dury, Sandra; Renois, Fanny; Deslee, Gaëtan; Wolak, Aurore; Duval, Véronique; De Champs, Christophe; Lebargy, François; Andreoletti, Laurent title: Detection of multiple viral and bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: A pilot prospective study date: 2013-02-27 journal: J Med Virol DOI: 10.1002/jmv.23495 sha: doc_id: 329442 cord_uid: ycj6sf6z Few studies have evaluated the contribution of multiple virus and bacterial infections in acute exacerbation of chronic obstructive pulmonary disease. keywords: acute; disease; et al; exacerbation; infections; patients; virus cache: cord-329442-ycj6sf6z.txt plain text: cord-329442-ycj6sf6z.txt item: #63 of 68 id: cord-331910-s474ecvk author: Thota, Sai Manohar title: Natural products as home‐based prophylactic and symptom management agents in the setting of COVID‐19 date: 2020-08-17 words: 8699 flesch: 22 summary: Drug Design A trial of Lopinavir-Ritonavir in adults hospitalized with severe Covid-19 Vitamin C and immune function Features, evaluation and treatment coronavirus (COVID-19) Vitamin C in disease prevention and cure: An overview Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines Effects of curcumin on pulmonary fibrosis and functions of paraquatchallenged rats Apigenin protects against bleomycin-induced lung fibrosis in rats Protective roles of Cordyceps on lung fibrosis in cellular and rat models β-Patchoulene from patchouli oil protects against LPSinduced acute lung injury via suppressing NF-κB and activating Nrf2 pathways Oxidative stress and pulmonary fibrosis Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: A retrospective study Does Carica papaya leaf-extract increase the platelet count? Neem (Azadirachta indica) has potential therapeutic benefits against pulmonary fibrosis pulmonary inflammation, acute lung injury, and alveolar damage. keywords: acute; antioxidant; bleomycin; cells; coronavirus; covid-19; effects; et al; fibrosis; infection; injury; levels; lung; mice; patients; rats; sars; study; symptoms; syndrome; tgf cache: cord-331910-s474ecvk.txt plain text: cord-331910-s474ecvk.txt item: #64 of 68 id: cord-331939-6okbdw7a author: Sin, David title: Acute pulmonary embolism multimodality imaging prior to endovascular therapy date: 2020-08-30 words: 7405 flesch: 35 summary: A simple score for rapid risk assessment of non-high-risk pulmonary embolism Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis A pulmonary embolism response team (PERT) approach: initial experience from the Cleveland Clinic Pulmonary embolism response teams Impact of multidisciplinary pulmonary embolism response team availability on management and outcomes Endovascular therapy for acute pulmonary embolism Endovascular therapy for acute severe pulmonary embolism A prospective, single-arm, multicenter trial of ultrasound-facilitated, catheter-directed, low-dose fibrinolysis for acute massive and submassive pulmonary embolism: the SEATTLE II Study Randomized, controlled trial of ultrasound-assisted catheter-directed thrombolysis for acute intermediate-risk pulmonary embolism Catheter-tip embolectomy in the management of acute massive pulmonary embolism Catheter-directed therapy for the treatment of massive pulmonary embolism: systematic review and meta-analysis of modern techniques Pulmonary embolism response to fragmentation, embolectomy, and catheter thrombolysis (PER-FECT): initial results from a prospective multicenter registry A randomized trial of the optimum duration of acoustic pulse thrombolysis procedure in acute intermediate-risk pulmonary embolism: The OPTALYSE PE Trial Management of suspected acute pulmonary embolism in the era of CT angiography: a statement from the Fleischner Society Suspected acute pulmonary embolism: evaluation with multi-detector row CT versus digital subtraction pulmonary arteriography Dual-energy CT of the heart for diagnosing coronary artery stenosis and myocardial ischemia-initial experience Update on cardiovascular applications of multienergy CT State of the art: utility of multi-energy CT in the evaluation of pulmonary vasculature Dual-energy CT: spectrum of thoracic abnormalities Dualenergy CT: clinical applications in various pulmonary diseases Chronic thromboembolic pulmonary hypertension Dual-energy CT (DECT) lung perfusion in pulmonary hypertension: concordance rate with V/Q scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH) Dual-energy MDCT: comparison of pulmonary artery enhancement on dedicated CT pulmonary angiography, routine and low contrast volume studies The indeterminate CT pulmonary angiogram: imaging characteristics and patient clinical outcome Prognostic value of perfusion defect volume at dual energy CTA in patients with pulmonary embolism: correlation with CTA obstruction scores, CT parameters of right ventricular dysfunction and adverse clinical outcome Spectral optimization of chest CT angiography with reduced iodine load: experience in 80 patients evaluated with dual-source, dual-energy CT Low-contrast agent dose dual-energy CT monochromatic imaging in pulmonary angiography versus routine CT High-pitch computed tomography pulmonary angiography with iterative reconstruction at 80 kVp and 20 mL contrast agent volume High pitch, low voltage dual source CT pulmonary angiography: assessment of image quality and diagnostic acceptability with hybrid iterative reconstruction State-of-the-art pulmonary CT angiography for acute pulmonary embolism Iterative reconstruction and automatic tube voltage selection reduce clinical CT radiation doses and image noise CT pulmonary angiography: dose reduction via a next generation iterative reconstruction algorithm Multidetector computed tomography for acute pulmonary embolism: diagnosis and risk stratification in a single test Dual-energy CT for imaging of pulmonary hypertension: challenges and opportunities Comparative assessment of qualitative and quantitative perfusion with dual-energy CT and planar and SPECT-CT V/Q scanning in patients with chronic thromboembolic pulmonary hypertension Lung perfused blood volume images with dual-energy computed tomography for chronic thromboembolic pulmonary hypertension: correlation to scintigraphy with singlephoton emission computed tomography Severity assessment of pulmonary embolism using dual energy CT-correlation of a pulmonary perfusion defect score with clinical and morphological parameters of blood oxygenation and right ventricular failure Advanced imaging in pulmonary hypertension: emerging techniques and applications Imaging in chronic thromboembolic pulmonary hypertension Reference values for normal pulmonary artery dimensions by noncontrast cardiac computed tomography: the Framingham Heart Study Prediction of pulmonary hypertension in patients with or without interstitial lung disease: reliability of CT findings A CT sign of chronic pulmonary arterial hypertension: the ratio of main pulmonary artery to aortic diameter Signs of right ventricular dysfunction: prognostic role in acute pulmonary embolism Predictive value of computed tomography in acute pulmonary embolism: systematic review and meta-analysis Computed tomography to assess risk of death in acute pulmonary embolism: a meta-analysis Indeterminate CT pulmonary angiogram: why and does it matter Yield of CT pulmonary angiography in the diagnosis of acute pulmonary embolism: short report Suboptimal CT pulmonary angiography in the emergency department: a retrospective analysis of outcomes in a large academic medical center Comparison of interpretations of CT angiograms in the evaluation of suspected pulmonary embolism by on-call radiology fellows and subsequently by radiology faculty Diagnosis of acute pulmonary embolism in outpatients: comparison of thin-collimation multi-detector row spiral CT and planar ventilation-perfusion scintigraphy Prospective comparison of helical CT with angiography in pulmonary embolism: global and selective vascular territory analysis. for the Clinical Guidelines Committee of the American College of Physicians (2015) Evaluation of patients with suspected acute pulmonary embolism: best practice advice from the Clinical Guidelines Committee of the American College of Physicians Task Force for the Diagnosis, and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) (2014) 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism keywords: acute; angiography; contrast; ctpa; embolism; energy; images; imaging; patients; perfusion; pulmonary; right; risk; study cache: cord-331939-6okbdw7a.txt plain text: cord-331939-6okbdw7a.txt item: #65 of 68 id: cord-334528-xenq90xj author: Chen, Hsing I title: Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations date: 2011-03-17 words: 5315 flesch: 29 summary: I. Light microscopy Ventilator-induced lung injury Cellular stress failure in ventilator-injured lungs Acute respiratory distress syndrome: a historical perspective The acute respiratory distress syndrome Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management Leukocyte elastase: physiological functions and role in acute lung injury Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit Chemokines in acute respiratory distress syndrome Transcriptional mechanisms of acute lung injury Alveolar epithelial fluid transport in acute lung injury: new insights Mechanisms of pulmonary edema clearance Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story Critical care in AJRCCM Alveolar recruitment in acute lung injury Prone position augments recruitment and prevents alveolar overinflation in acute lung injury Hypercapnic acidosis attenuates endotoxin-induced acute lung injury Protective effects of hypercapnic acidosis on ventilator-induced lung injury Permissive hypercapnia: role in protective lung ventilatory strategies Hypercapnia via reduced rate and tidal volume contributes to lipopolysaccharide-induced lung injury Permissive hypercapnia impairs pulmonary gas exchange in the acute respiratory distress syndrome Nonventilatory treatments for acute lung injury and ARDS Ventilatory management of acute lung injury and acute respiratory distress syndrome Acute respiratory distress syndrome: pharmacological treatment options in development Pathophysiology and pharmacological treatment of pulmonary hypertension in acute respiratory distress syndrome Inhaled nitric oxide therapy in adults Exercise training attenuates septic responses in conscious rats Vascular endothelial growth factor and related molecules in acute lung injury Angiotensin-converting enzyme 2 protects from severe acute lung failure Insulin attenuates endotoxin-induced acute lung injury in conscious rats Comparison of propofol and midazolam for sedation in critically ill patients An update of its use in anaesthesia and conscious sedation The reduction of tumor necrosis factor-alpha release and tissue damage by pentobarbital in the experimental endotoxemia model N-acetylcysteine ameliorates lipopolysaccharide-induced organ damage in conscious rats Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats N-Acetylcysteine treatment to prevent the progression of multisystem organ failure: a prospective, randomized, placebo-controlled study Antioxidant supplementation in sepsis and systemic inflammatory response syndrome N-acetylcysteine as the magic bullet: too good to be true Experimental studies and clinical investigations were supported in part by grants from the National Science Council. [77, 78] Intratracheal instillation of hydrochloric acid (HCI) or gastric particles has been employed as experimental model of acute lung injury (ALI). keywords: acid; acute; ali; ards; distress; injury; inos; lung; nitric; oxide; pulmonary; rats; syndrome cache: cord-334528-xenq90xj.txt plain text: cord-334528-xenq90xj.txt item: #66 of 68 id: cord-335382-fk4um9nw author: Farver, Carol F. title: Molecular Basis of Pulmonary Disease date: 2012-08-10 words: 32359 flesch: 38 summary: In hyperoxia-induced cell death, hyperoxia may induce the expression of angiopoietin 2 (Ang2) in lung epithelial cells. Annual report to the nation on the status of cancer Pathology and Genetics of Tumours of the Lung, Pleura AJCC Cancer Staging Manual varying), National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released Diagnosis and management of lung cancer executive summary: ACCP evidence-based clinical practice guidelines Genetics of preneoplasia: Lessons from lung cancer Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering High resolution analysis of non-small cell lung cancer cell lines by whole genome tiling path array CGH Lung cancer preneoplasia Characterizing the cancer genome in lung adenocarcinoma Focus on lung cancer New molecularly targeted therapies for lung cancer High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints Genetic and molecular alterations Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma Hereditary cancers disclose a class of cancer genes Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers Molecular oncogenesis of lung cancer Molecular genetics of lung cancer The P16/cyclin D1/ keywords: airways; alveolar; asthma; carcinoids; cases; cause; cell lung; cells; changes; chest; chronic; disease; epithelium; factor; features; fibrosis; figure; form; gene; human; infections; inflammatory; injury; lesions; loss; lung; lung cancer; lung disease; macrophages; mechanisms; mutations; organisms; pathogenesis; pathology; patients; pneumonia; present; proliferation; protein; pulmonary; response; result; role; sarcoidosis; studies; surfactant; tissue; tumor; type cache: cord-335382-fk4um9nw.txt plain text: cord-335382-fk4um9nw.txt item: #67 of 68 id: cord-335597-anrzcsrt author: None title: 44. Jahrestagung der Österreichischen Gesellschaft für Pneumologie date: 2020-10-26 words: 14654 flesch: 44 summary: Methods: We performed single cell RNA sequencing on pulmonary arteries isolated from donors and pulmonary hypertension patients. Arteries in pulmonary hypertension patients displayed altered composition of EC population characterized by the diminished presence of one cell cluster. keywords: age; analysis; asthma; background; cell; cohort; conclusions; copd; covid-19; data; disease; eine; exercise; function; inflammatory; lung; mean; median; methods; mit; months; mortality; p =; pain; patients; pulmonary; results; score; study; survival; symptoms; therapy; treatment; years cache: cord-335597-anrzcsrt.txt plain text: cord-335597-anrzcsrt.txt item: #68 of 68 id: cord-352532-xqphom6x author: Papanikolaou, Ilias C title: 1 Tropical Lung Diseases date: 2013-12-31 words: 3342 flesch: 38 summary: In a typical tropical clinic, 20-40% of outpatients have respiratory complaints, and 20-30% of inpatients have lung disease (Table 1-1) Many tropical patients suffer from lung diseases that are found worldwide, e.g. asthma, bronchiectasis, chronic obstructive lung disease, HIV infection-related lung disease, and lung cancer. keywords: chest; children; cough; disease; fever; lung; patients; pneumonia; pulmonary; sputum cache: cord-352532-xqphom6x.txt plain text: cord-352532-xqphom6x.txt